title: Malignant pilomatricoma with multiple bone metastases in a dog: Histological and immunohistochemical study.
abstract: An eleven year-old mongrel dog was referred with a history of left forelimb lameness and an ulcerated mass on the neck. Histologically, the cutaneous neoplasm revealed cystic lobules composed of basaloid cells with abrupt transition to central keratotic material, containing pycnotic and shadow cells. Approximately 3 months after primary diagnosis, a lesion of the cortical bone on the left humerus was observed using X-ray. Samples obtained from the humerus were processed for histopathological examination and the neoplastic tissue was observed to be similar to the type identified in the neck. Based on these findings, the tumor was diagnosed as a malignant pilomatricoma (MP) with bone metastasis. MP is a rare skin tumor that originates from hair matrix cells. To date, only nine reports have been presented in dogs. In the present study, we discuss the cytological and histological patterns of MP, confirmed by immunohistochemistry using β catenin antibody.
authors.affiliation: Department of Pathology and Animal Health, Faculty of Biotechnological Sciences, University Federico II -Via Delpino, Naples I-80137;
authors.forename: Manuela
authors.initials: M
authors.lastname: Martano
authors.forename: Luigi
authors.initials: L
authors.lastname: Navas
authors.forename: Leonardo
authors.initials: L
authors.lastname: Meomartino
authors.forename: Francesca
authors.initials: F
authors.lastname: Abramo
authors.forename: Brunella
authors.initials: B
authors.lastname: Restucci
authors.forename: Paola
authors.initials: P
authors.lastname: Maiolino
authors.forename: Lorenzo Lo
authors.initials: LL
authors.lastname: Muzio
keywords: dog; immunohistochemistry; malignant pilomatricoma