title: Building robust functionality in synthetic circuits using engineered feedback regulation.
abstract: The ability to engineer novel functionality within cells, to quantitatively control cellular circuits, and to manipulate the behaviors of populations, has many important applications in biotechnology and biomedicine. These applications are only beginning to be explored. In this review, we advocate the use of feedback control as an essential strategy for the engineering of robust homeostatic control of biological circuits and cellular populations. We also describe recent works where feedback control, implemented in silico or with biological components, was successfully employed for this purpose.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Chen
authors.forename: Patrick
authors.initials: P
authors.lastname: Harrigan
authors.forename: Benjamin
authors.initials: B
authors.lastname: Heineike
authors.forename: Jacob
authors.initials: J
authors.lastname: Stewart-Ornstein
authors.forename: Hana
authors.initials: H
authors.lastname: El-Samad
mesh_terms: D000818:Animals; D003198:Computer Simulation; D005246:Feedback; D006801:Humans; D060847:Metabolic Engineering