title: Toxoplasma encephalitis in HIV/AIDS patients admitted to the Douala general hospital between 2004 and 2009: a cross sectional study.
abstract: BACKGROUND
  It is estimated that about a third of the world's population is chronically infected with Toxoplasma gondii. Toxoplasma encephalitis (TE), which occurs as a reactivation of quiescent chronic infection, is one of the leading causes of central nervous system (CNS) infection in AIDS. Its diagnosis in most centres still remains difficult. We opted to describe the clinical and radiological features of TE as well as in-hospital outcome and its associated factors.
  
  
  METHODS
  We carried out a cross sectional study on the clinical case notes of adult patients admitted and treated for TE at the Douala General Hospital, Cameroon between January 1st 2004 to December 31st 2009.
  
  
  RESULTS
  Of 672 patients admitted during the study period, 14.4% (97/672) had TE. The mean age was 36.9 ± 14.1 years and the median CD4 cell count was 68/mm3 (IQR): 43 - 103). Headache and fever were the most common presenting symptoms in 92.8% (90/97) and 87.6% (85/97) of patients. Annular contrast enhanced lesions were the most common brain scan finding in 81.4% (79/97) of patients. In-hospital mortality was 29.9% (29/97). Altered sensorium, presence of focal signs, neck stiffness and low CD4 cell count were factors associated with mortality. Adjusting for low CD4 count, altered sensorium remained strongly associated with fatality, adjusted odd ratio (AOR) 3.5 (95% CI 1.2 - 10.5).
  
  
  CONCLUSIONS
  Toxoplasma encephalitis is common among AIDS patients in Douala. Its high case fatality warrants adequate and compliant prophylactic therapy in severely immune depressed patients as well as early initiation of antiretroviral therapy in HIV-infected patients.
authors.forename: Henry Namme
authors.initials: HN
authors.lastname: Luma
authors.forename: Benjamin Clet Nguenkam
authors.initials: BC
authors.lastname: Tchaleu
authors.forename: Yacouba Njankouo
authors.initials: YN
authors.lastname: Mapoure
authors.forename: Elvis
authors.initials: E
authors.lastname: Temfack
authors.forename: Marie Solange
authors.initials: MS
authors.lastname: Doualla
authors.forename: Marie Patrice
authors.initials: MP
authors.lastname: Halle
authors.forename: Henry Achu
authors.initials: HA
authors.lastname: Joko
authors.forename: Sinata
authors.initials: S
authors.lastname: Koulla-Shiro
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications*; D000328:Adult; D002163:Cameroon; D003430:Cross-Sectional Studies; D004660:Encephalitis / Q000150:complications*; D006769:Hospitals, General; D006801:Humans; D008875:Middle Aged; D010343:Patient Admission; D014123:Toxoplasmosis / Q000150:complications*