title: Inflammatory myofibroblastic tumour of the skull base.
abstract: Inflammatory myofibroblastic tumors (IMTs) are rare benign clinical and pathological entities. IMTs have been described in the lungs, abdomen, retroperitoneum, and extremities but rarely in the head and neck region. A 38-year-old man presented with headache, right exophthalmia, and right 6th nerve palsy. A CT scan revealed enlargement of the right cavernous sinus and osteolytic lesions of the right sphenoid and clivus. MR imaging showed a large tumor of the skull base which was invading the sella turcica, right cavernous sinus, and sphenoidal sinus. A biopsy was performed and revealed an IMT. Corticosteroids were given for 3 months but were inefficient. In the framework of our pluridisciplinary consultation, fractionated conformal radiotherapy (FRT) was indicated at a low dose; 20 Gy in 10 fractions of 2 Gy over 12 days were delivered. Clinical response was complete 3 months after FRT. Radiological response was subtotal 6 months after FRT. Two years later, the patient is well.
authors.affiliation: Department of Radiation Oncology, Saint-André University Hospital, University Bordeaux Segalen, 33076 Bordeaux, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Maire
authors.forename: Sandrine
authors.initials: S
authors.lastname: Eimer
authors.forename: François
authors.initials: F
authors.lastname: San Galli
authors.forename: Valérie
authors.initials: V
authors.lastname: Franco-Vidal
authors.forename: Sigolène
authors.initials: S
authors.lastname: Galland-Girodet
authors.forename: Aymeri
authors.initials: A
authors.lastname: Huchet
authors.forename: Vincent
authors.initials: V
authors.lastname: Darrouzet