title: International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions.
abstract: BACKGROUND
  There has been tremendous growth in research in pediatric multiple sclerosis (MS) and immune mediated central nervous system demyelinating disorders since operational definitions for these conditions were first proposed in 2007. Further, the International Pediatric Multiple Sclerosis Study Group (IPMSSG), which proposed the criteria, has expanded substantially in membership and in its international scope.
  
  
  OBJECTIVE
  The purpose of this review is to revise the 2007 definitions in order to incorporate advances in delineating the clinical and neuroradiologic features of these disorders.
  
  
  METHODS
  Through a consensus process, in which input was sought from the 150 members of the Study Group, criteria were drafted, revised and finalized. Final approval was sought through a web survey.
  
  
  RESULTS
  Revised criteria are proposed for pediatric acute disseminated encephalomyelitis, pediatric clinically isolated syndrome, pediatric neuromyelitis optica and pediatric MS. These criteria were approved by 93% or more of the 56 Study Group members who responded to the final survey.
  
  
  CONCLUSIONS
  These definitions are proposed for clinical and research purposes. Their utility will depend on the outcomes of their application in prospective research.
authors.affiliation: Lourie Center for Pediatric MS. Stony Brook University Medical Center, USA. lauren.krupp@stonybrook.edu
authors.forename: Lauren B
authors.initials: LB
authors.lastname: Krupp
authors.forename: Marc
authors.initials: M
authors.lastname: Tardieu
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Amato
authors.forename: Brenda
authors.initials: B
authors.lastname: Banwell
authors.forename: Tanuja
authors.initials: T
authors.lastname: Chitnis
authors.forename: Russell C
authors.initials: RC
authors.lastname: Dale
authors.forename: Angelo
authors.initials: A
authors.lastname: Ghezzi
authors.forename: Rogier
authors.initials: R
authors.lastname: Hintzen
authors.forename: Andrew
authors.initials: A
authors.lastname: Kornberg
authors.forename: Daniela
authors.initials: D
authors.lastname: Pohl
authors.forename: Kevin
authors.initials: K
authors.lastname: Rostasy
authors.forename: Silvia
authors.initials: S
authors.lastname: Tenembaum
authors.forename: Evangeline
authors.initials: E
authors.lastname: Wassmer
mesh_terms: D002648:Child; D020278:Demyelinating Autoimmune Diseases, CNS / Q000175:diagnosis*; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis*; D006801:Humans; D009103:Multiple Sclerosis / Q000175:diagnosis*; D009471:Neuromyelitis Optica / Q000175:diagnosis*; D010372:Pediatrics / Q000592:standards*
keywords: Multiple sclerosis; acute disseminated encephalomyelitis; childhood multiple sclerosis; clinically isolated syndrome; neuromyelitis optica; pediatric multiple sclerosis