title: Proteomic analysis of venous thromboembolism: an update.
abstract: Venous thromboembolism is a complex, multifactorial disorder, the pathogenesis of which typically involves a variety of inherited or acquired factors. The multifactorial etiology of this disease and the partial correlation between genotype and prothrombotic phenotype limit greatly the value of genetic analysis in assessing thrombotic risk. The integration of several new 'omics' techniques enables a multifaceted and holistic approach to the study of venous thrombotic processes and pave the way to the search and identification of novel blood biomarkers and/or effectors of thrombus formation that can also be the possible future target of new anticoagulant and thrombolytic therapies for more personalized medicine. This review provides a comprehensive overview of the latest candidate proteomic biomarkers of venous thrombosis and of the proteomics studies relevant to its pathophysiology, some of which seem to confirm the existence of a common physiopathological basis for venous thromboembolism and atherothrombosis.
authors.affiliation: UOC di Immunoematologia e Medicina Trasfusionale and UOC di Patologia Clinica, San Giovanni Calibita Fatebenefratelli Hospital, 00186 Rome, Italy. giancarlo@liumbruno.it
authors.forename: Giancarlo Maria
authors.initials: GM
authors.lastname: Liumbruno
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
mesh_terms: D000818:Animals; D006801:Humans; D040901:Proteomics / Q000379:methods*; D054556:Venous Thromboembolism / Q000097:blood* / Q000378:metabolism* / Q000503:physiopathology