title: Cystatin C in assessment of glomerular filtration rate in children and young adults suffering from cancer.
abstract: The study objective was to establish the diagnostic efficacy of cystatin C in the assessment of glomerular filtration rate (GFR) in paediatric oncology patients by investigating the relationships between serum cystatin C, serum creatinine and isotope clearance and determining whether these relationships are different from those seen in a group of patients of similar age with renal disease. This was a cohort study in which patients were divided into two groups: group A comprised renal patients and group B comprised oncology patients. All patients were referred for isotopic GFR assessment as part of routine clinical management and concurrently also had assessments made of their serum creatinine and cystatin C levels, together with height and weight measurements. Reciprocals of cystatin C correlate well with isotopic GFR; correlation coefficients from linear regression were 0.83 and 0.66 for the renal and oncology groups, respectively. However, when GFR was assessed from serum creatinine and cystatin C, levels of agreement were still very high (95% levels of agreement: -33 and 31 ml/min/1.73 m for cystatin C and -46 and 30 ml/min/1.73 m for the Counahan serum creatinine estimate). Receiver-operator characteristic curve analysis demonstrated that cystatin C has improved diagnostic utility for identifying patients with GFRs both below normal (90 ml/min/1.73 m) and below the point at which chemotherapy dose reduction may be considered (60 ml/min/1.73 m). Levels of intrapatient variability were similar for both tracers. Cystatin C was shown to be a better indicator of renal function compared with serum creatinine in oncology patients as demonstrated by receiver-operator characteristic curve and Bland-Altman analyses; however, sensitivity of the tracer to mild reductions in GFR is still low.
authors.affiliation: Department of Medical Physics, St James's Hospital Departments of, Leeds General Infirmary, Leeds, UK. mcb@medphysics.leeds.ac.uk
authors.forename: Mark C
authors.initials: MC
authors.lastname: Barnfield
authors.forename: Maria T
authors.initials: MT
authors.lastname: Burniston
authors.forename: Una
authors.initials: U
authors.lastname: Reid
authors.forename: Alastair M
authors.initials: AM
authors.lastname: Graham
authors.forename: Mick
authors.initials: M
authors.lastname: Henderson
authors.forename: Susan V
authors.initials: SV
authors.lastname: Picton
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D045604:Extracellular Fluid / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000097:blood* / Q000473:pathology / Q000503:physiopathology*; D012372:ROC Curve; D055815:Young Adult
chemical_list: D055316:Cystatin C; D003404:Creatinine