title: A review of statin use in patients with acute coronary syndrome in Western and Japanese populations.
abstract: Early high-dose statin therapy to reduce low-density lipoprotein cholesterol (LDL-C) is associated with improved cardiovascular outcomes in Western patients with stable coronary heart disease or acute coronary syndromes (ACS), but many patients remain undertreated and do not attain LDL-C treatment goals. Early statin therapy has also been shown to improve cardiovascular outcomes in Japanese patients with ACS, and pretreatment with high-dose statin prior to percutaneous coronary intervention has been shown to reduce cardiovascular events in these patients. As is the case in Western populations, many Japanese patients may be undertreated and a residual cardiovascular risk remains. While differences in treatment practice, dosing and genetic factors exist between Japan and Western countries, similarities are also evident when Japanese statin studies are compared with those performed in Western populations. With the increasing prevalence of cardiovascular risk factors in Japan, aggressive statin treatment may be beneficial in achieving optimal cardiovascular outcomes.
authors.affiliation: Department of Cardiovascular Medicine, School of Medicine, Juntendo University, Tokyo, Japan. ktmmy@juntendo.ac.jp
authors.forename: Katsumi
authors.initials: K
authors.lastname: Miyauchi
authors.forename: Kausik
authors.initials: K
authors.lastname: Ray
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000188:drug therapy* / Q000208:ethnology / Q000401:mortality; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D044466:Asian People; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy* / Q000208:ethnology / Q000401:mortality; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome; D044465:White People
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Acute coronary syndrome; Japan; cardiovascular risk; low-density lipoprotein cholesterol; statin