title: Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population.
abstract: BACKGROUND
  Multiple Sclerosis (MS) is a neurodegenerative disease. It involves inflammation and demyelination. Since cytokines play an important role in the development of MS, genes encoding cytokines such as the Interleukin (IL)-1 family are candidate genes for MS susceptibility.
  
  
  OBJECTIVE
  To determine the relationship between IL-1 gene family and MS in the Turkish population.
  
  
  METHODS
  A total of 409 MS patients and 256 healthy controls were included in the study. IL-1A -889 (rs1800587), IL-1 RN variable number tandom repeat (VNTR), IL-1B -511 (rs 16944) and IL-1B +3953 (rs 1143634) polymorphisms were investigated from the genomic DNA, obtained via blood samples.
  
  
  RESULTS
  No association was found between IL-1A and IL-1RN polymorphisms and susceptibility to MS. However, we have found significantly decreased frequency of IL-1B -511 genotype (p = 0.004) in MS patients compared to controls. In addition, there was a significant association between IL-1B -511 (1/2) genotype and early onset MS (EOMS) (p = 0.0001).
  
  
  CONCLUSIONS
  Individuals with the 2/2 genotype of IL-1B -511 have significantly decreased incidence of MS, suggesting a protective role for this genotype in the Turkish population. Additionally, IL-1B -511 (1/2) genotype was determined as a possible risk factor for EOMS.
authors.affiliation: 1Department of Neurology, Medeniyet University Goztepe Training and Research Hospital , Istanbul , Turkey.
authors.forename: Nihal
authors.initials: N
authors.lastname: Isik
authors.forename: Ahmet
authors.initials: A
authors.lastname: Arman
authors.forename: Ilknur Aydın
authors.initials: IA
authors.lastname: Canturk
authors.forename: Ajda Coker
authors.initials: AC
authors.lastname: Gurkan
authors.forename: Fatma
authors.initials: F
authors.lastname: Candan
authors.forename: Sule
authors.initials: S
authors.lastname: Aktan
authors.forename: Nilufer
authors.initials: N
authors.lastname: Erzaim
authors.forename: Ozge Arici
authors.initials: OA
authors.lastname: Duz
authors.forename: Tugrul
authors.initials: T
authors.lastname: Aydin
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Turkes
authors.forename: Edward O
authors.initials: EO
authors.lastname: List
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D016207:Cytokines / Q000235:genetics; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D053583:Interleukin-1beta; D004247:DNA