title: An update on the ocular phenotype in patients with pseudoxanthoma elasticum.
abstract: Pseudoxanthoma elasticum (PXE) is an inherited multi-system disorder characterized by ectopic mineralization and fragmentation of elastic fibers in the skin, the elastic laminae of blood vessels and Bruch's membrane in the eye. Biallelic mutations in the ATP-binding cassette (ABC) transporter gene ABCC6 on chromosome 16 are responsible for the disease. The pathophysiology is incompletely understood. However, there is consent that a metabolic alteration leads to dysfunction in extracellular calcium homeostasis and subsequent calcification of connective tissues rich in elastic fibers. This review summarizes and aims at explaining the variety of phenotypic ocular findings in patients with PXE. Specialized imaging techniques including white light fundus photography, blue light autofluorescence, near-infrared confocal reflectance imaging, high resolution optical coherence tomography, fluorescein and indocyanine green (ICG) angiography have revealed characteristic lesions at the ocular fundus of PXE patients. These include the classic signs of angioid streaks, peau d'orange, comet lesions, and choroidal neovascularizations (CNVs), but also the more recently recognized features such as chorioretinal atrophy, subretinal fluid independent from CNV, pattern dystrophy-like changes, debris accumulation under the retinal pigment epithelium, reticular drusen and a decreased fluorescence on late phase ICG angiography.
authors.affiliation: Department of Ophthalmology, University of Bonn Bonn, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Gliem
authors.forename: Julie De
authors.initials: JD
authors.lastname: Zaeytijd
authors.forename: Robert P
authors.initials: RP
authors.lastname: Finger
authors.forename: Frank G
authors.initials: FG
authors.lastname: Holz
authors.forename: Bart P
authors.initials: BP
authors.lastname: Leroy
authors.forename: Peter
authors.initials: P
authors.lastname: Charbel Issa
keywords: Bruch’s membrane; angioid streaks; choroidal neovascularization; pseudoxanthoma elasticum; retina