title: Autism, seasonality and the environmental perturbation of epigenome related vitamin levels.
abstract: An argument is put forward for environmental modulators of photolabile or photosynthetic vitamins mediating autism risk via a complex downstream interaction of genetic/epigenetic phenomena that provide an explanation for seasonality in this and other developmentally originated disorders.
authors.affiliation: Molecular Nutrition Laboratory, School of Environmental and Life Sciences, University of Newcastle, New South Wales, Australia. Mark.Lucock@newcastle.edu.au
authors.forename: Mark
authors.initials: M
authors.lastname: Lucock
authors.forename: Robert
authors.initials: R
authors.lastname: Leeming
mesh_terms: D001708:Biopterins / Q000009:adverse effects / Q000031:analogs & derivatives; D002659:Child Development Disorders, Pervasive / Q000209:etiology*; D005260:Female; D005492:Folic Acid / Q000378:metabolism; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000378:metabolism; D008954:Models, Biological; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D012621:Seasons; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014815:Vitamins / Q000528:radiation effects* / Q000633:toxicity
chemical_list: D014815:Vitamins; D001708:Biopterins; D005492:Folic Acid; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); C003402:sapropterin