title: Micellar nanoparticle formation via electrostatic interactions for delivering multinuclear platinum(II) drugs.
abstract: Nanoparticles formed via electrostatic interactions between methoxy-polyethylene glycol-block-poly(glutamic acid) (MPEG-PGA) and a multinuclear platinum(II) drug, di-cisPt, exhibit efficient platinum loading, improved cellular uptake, in vitro cytotoxicity, and enhanced in vivo efficacy.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
authors.forename: Haihua
authors.initials: H
authors.lastname: Xiao
authors.forename: Jared F
authors.initials: JF
authors.lastname: Stefanick
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Jia
authors.forename: Xiabin
authors.initials: X
authors.lastname: Jing
authors.forename: Tanyel
authors.initials: T
authors.lastname: Kiziltepe
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Basar
authors.initials: B
authors.lastname: Bilgicer
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011099:Polyglutamic Acid / Q000737:chemistry; D055672:Static Electricity
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D011099:Polyglutamic Acid; D011092:Polyethylene Glycols; D002945:Cisplatin