title: Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.
abstract: The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.
authors.affiliation: Wellcome Trust Centre for Cell Biology, University of Edinburgh, Mayfield Road, Edinburgh, Scotland, UK. bill.earnshaw@ed.ac.uk
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mesh_terms: D001324:Autoantigens / Q000235:genetics* / Q000378:metabolism; D002503:Centromere; D000076247:Centromere Protein A; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics* / Q000378:metabolism; D006657:Histones / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D018386:Kinetochores; D012595:Scleroderma, Systemic / Q000235:genetics; D009626:Terminology as Topic
chemical_list: D001324:Autoantigens; C000619700:CENPA protein, human; D000076247:Centromere Protein A; D002868:Chromosomal Proteins, Non-Histone; D006657:Histones