title: Central body fat distribution associates with unfavorable renal hemodynamics independent of body mass index.
abstract: Central distribution of body fat is associated with a higher risk of renal disease, but whether it is the distribution pattern or the overall excess weight that underlies this association is not well understood. Here, we studied the association between waist-to-hip ratio (WHR), which reflects central adiposity, and renal hemodynamics in 315 healthy persons with a mean body mass index (BMI) of 24.9 kg/m(2) and a mean (125)I-iothalamate GFR of 109 ml/min per 1.73 m(2). In multivariate analyses, WHR was associated with lower GFR, lower effective renal plasma flow, and higher filtration fraction, even after adjustment for sex, age, mean arterial pressure, and BMI. Multivariate models produced similar results regardless of whether the hemodynamic measures were indexed to body surface area. Thus, these results suggest that central body fat distribution, independent of BMI, is associated with an unfavorable pattern of renal hemodynamic measures that could underlie the increased renal risk reported in observational studies.
authors.affiliation: Department of Medicine, University Medical Center Groningen, The Netherlands. a.kwakernaak@umcg.nl
authors.forename: Arjan J
authors.initials: AJ
authors.lastname: Kwakernaak
authors.forename: Dorien M
authors.initials: DM
authors.lastname: Zelle
authors.forename: Stephan J L
authors.initials: SJ
authors.lastname: Bakker
authors.forename: Gerjan
authors.initials: G
authors.lastname: Navis
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D050218:Body Fat Distribution; D015992:Body Mass Index; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012079:Renal Circulation / Q000502:physiology*; D012307:Risk Factors
chemical_list: D001786:Blood Glucose