title: Treatment of chronic ulcer with elastic plasma protein and platelet film for wound dressing.
abstract: Experimental results have previously been reported for a new biological dressing consisting of concentrated plasma proteins and platelet-rich plasma (PRP), which is named Platelet-Protein film (PPF). This study reports clinical experience using PPF produced from the patients' own blood by the original technique. Ten patients with chronic wounds underwent PPF treatment and evaluated the transcutaneous oxygen tension (TcPO2) and vascular density. Eight of the 10 patients received a split-thickness skin graft on induced granulation tissue and have remained free from complications for more than 12 months since treatment. The TcPO2 values significantly increased at 4 days after treatment (before 38.4 (14.1) mmHg, after 55 (19.9) mmHg, p < 0.01). The vascular density at the ulcer base increased at 14 days after treatment in all the cases. The results showed that PPF has the potential to enhance chronic wound healing.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Saitama Medical University.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Sano
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ichioka
authors.forename: Ai
authors.initials: A
authors.lastname: Minamimura
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Tanaka
authors.forename: Kenji
authors.initials: K
authors.lastname: Ikebuchi
authors.forename: Miho
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001684:Biological Dressings; D001785:Blood Gas Monitoring, Transcutaneous; D001798:Blood Proteins / Q000627:therapeutic use*; D002908:Chronic Disease; D003646:Debridement; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism; D053657:Platelet-Rich Plasma / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D012867:Skin / Q000098:blood supply; D016038:Skin Transplantation; D012883:Skin Ulcer / Q000473:pathology / Q000628:therapy*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D001798:Blood Proteins; D010100:Oxygen