title: [Adverse drug reactions and prescription errors: morbi-mortality].
abstract: Pharmacovigilance aims to detect, assess, understand and prevent any possible drug-related problem. The record of information related to adverse drug reactions (ADRs) after drug approval and risk management based on observational data are crucial for public health. The main goal was to assess the ADRs morbimortality and to describe prescription medical errors in a public hospital in the city of Buenos Aires. A prospective observational study was undertaken. ADR was defined as any clinical and/or biological noxious manifestation imputable to a drug, which occurs at the usually used dose in humans for disease prophylaxis, diagnosis or treatment. Global mortality was 7% (21/310). The observed mortality due to ADR accounted for 1% (3/310). One hundred and forty nine ADRs in 36% of patients were identified (111/310), and 11% (35/310) of the hospital admissions were due to ADRs. ADRs cause a great number of admissions and are responsible for preventable morbidity during hospitalization. Neither drug alone caused more than 6% of the ADRs. For this reason, in order to diminish ADRs, strategies should be addressed to multiple drug groups.
authors.affiliation: División B de Clínica Médica, Sección Epilepsia, Hospital General de Agudos José María Ramos Mejía, Buenos Aires, Argentina. sebastianchaio@gmail.com
authors.forename: Sebastián
authors.initials: S
authors.lastname: Chaio
authors.forename: Javier
authors.initials: J
authors.lastname: Toibaro
authors.forename: Pedro
authors.initials: P
authors.lastname: Valicenti
authors.forename: Patricia
authors.initials: P
authors.lastname: Saidón
mesh_terms: D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data*; D000368:Aged; D000369:Aged, 80 and over; D001118:Argentina / Q000453:epidemiology; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008508:Medication Errors / Q000401:mortality / Q000706:statistics & numerical data*; D008875:Middle Aged; D060735:Pharmacovigilance; D011446:Prospective Studies; D012907:Smoking / Q000453:epidemiology; D055815:Young Adult
keywords: adverse drug reactions; drug prescription errors; pharmacovigilance