title: Stem cell therapy for lower extremity diabetic ulcers: where do we stand?
abstract: The impairment of wound healing in diabetic patients is an important clinical problem affecting millions of patients worldwide. Various clinical and basic science studies show that stem cell therapy, as a regenerative medical therapy, can be a good solution. In this paper, we begin with an introduction of the cellular mechanism of the diabetic ulcer. We will then discuss the advantages and limitations of various stem cell therapies that have been under extensive recent study.
authors.affiliation: Division of Plastic Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794, USA.
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.forename: Lingling
authors.initials: L
authors.lastname: Sheng
authors.forename: Tian R
authors.initials: TR
authors.lastname: Zhang
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Li
mesh_terms: D064987:Cell- and Tissue-Based Therapy; D048909:Diabetes Complications / Q000150:complications / Q000473:pathology / Q000628:therapy*; D017719:Diabetic Foot / Q000150:complications / Q000473:pathology / Q000628:therapy*; D006801:Humans; D035002:Lower Extremity / Q000473:pathology; D018919:Neovascularization, Physiologic; D033581:Stem Cell Transplantation; D014945:Wound Healing