title: UP780, a chromone-enriched aloe composition improves insulin sensitivity.
abstract: BACKGROUND
  Diabetic individuals experience elevated fasting glucose, glycosylated hemoglobin (HbA1c), and plasma insulin and impaired glucose tolerance. Adiponectin is a hormone inversely correlated with insulin resistance. Here we describe the activity of aloesin, an aloe chromone that increases adiponectin production and, when formulated with an aloe polysaccharide composition, improves the insulin sensitivity in db/db and diet-induced obese-diabetic mice.
  
  
  METHODS
  Two aloe chromones, aloesin and aloesinol, were tested in vitro for adiponectin production. Following confirmation of glucose-lowering activity in a high-fat diet (HFD)-induced mouse model, aloesin was formulated with an Aloe vera inner leaf gel powder polysaccharide preparation to yield a composition designated UP780. Efficacy of UP780 was evaluated in HDF-induced and db/db mouse models. GW1929, a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist, was used as a positive control.
  
  
  RESULTS
  After 3 weeks of treatment of HDF-induced mice, plasma insulin levels were decreased 37.9% and 46.7% by aloesin and aloesinol, respectively. In db/db mice, the chromone- (2% chromone:98% aloe polysaccharide) enriched UP780 aloe composition showed a 33.7% and 46.0% decrease in fasting triglyceride and plasma glucose levels after 10 weeks of oral treatment, respectively. Diabetic mice gavaged with 200 mg/kg of UP780 for 10 weeks showed a 30.3% decrease in fasting blood glucose levels and a 32.2% reduction in plasma insulin. In both animal models, UP780 showed a statistically significant improvement in blood glucose clearance.
  
  
  CONCLUSIONS
  These findings indicate that UP780, a chromone-standardized, aloe-based composition, could potentially be used as a natural product option to facilitate the maintenance of healthy blood glucose levels.
authors.affiliation: Unigen, Inc., Seattle, WA 98121, USA. myimam@unigen.net
authors.forename: Mesfin
authors.initials: M
authors.lastname: Yimam
authors.forename: Jifu
authors.initials: J
authors.lastname: Zhao
authors.forename: Brandon
authors.initials: B
authors.lastname: Corneliusen
authors.forename: Mandee
authors.initials: M
authors.lastname: Pantier
authors.forename: Lidia Alfaro
authors.initials: LA
authors.lastname: Brownell
authors.forename: Qi
authors.initials: Q
authors.lastname: Jia
mesh_terms: D041721:3T3-L1 Cells; D052242:Adiponectin / Q000097:blood; D000504:Aloe / Q000737:chemistry*; D000818:Animals; D001577:Benzophenones / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D002867:Chromones / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy*; D059305:Diet, High-Fat; D005960:Glucosides / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology; D011134:Polysaccharides / Q000494:pharmacology; D014443:Tyrosine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D052242:Adiponectin; C499919:Adipoq protein, mouse; D001577:Benzophenones; D001786:Blood Glucose; D002867:Chromones; D005960:Glucosides; D007328:Insulin; D028321:Plant Preparations; D011134:Polysaccharides; D014443:Tyrosine; C120099:GW 1929; C069868:aloesin