title: [Genic and cellular therapy for peripheral arterial diseases].
abstract: Late evolution of peripheral arterial disease consists in the apparition of critical limb ischemia. Surgical treatments allow to treat these patients during long time; however, in most patients, especially the diabetic ones, there a very few options and the clinical evolution is rapidly dramatic. For these reasons, the critical limb ischemia is one of the first diseases treated by genic or cellular therapies aiming to improve blood flow perfusion in the lower-limbs. In this short review, we describe the main clinical trials of genic therapy; most of them have been abandoned because serious side effects, modest effects and major risks. Different types of stem cells are now used for cell therapy: endothelial progenitor cells, early or late, activated or not, mesenchymal stem cells, embryonic stem cells and human induced pluripotent stem cells. Problems of characterization are described and the results of the most important clinical trials are reported.
authors.affiliation: Inserm U 765, service d'hématologie biologique, hôpital européen Georges-Pompidou, faculté de pharmacie, université Paris-Descartes, 75006 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Smadja
authors.forename: J-S
authors.initials: JS
authors.lastname: Silvestre
authors.forename: B I
authors.initials: BI
authors.lastname: Lévy
mesh_terms: D000671:Amputation, Surgical; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use; D000818:Animals; D001162:Arteriosclerosis Obliterans / Q000628:therapy; D002199:Capillary Permeability; D064987:Cell- and Tissue-Based Therapy; D002478:Cells, Cultured / Q000637:transplantation; D002986:Clinical Trials as Topic; D003925:Diabetic Angiopathies / Q000628:therapy; D017719:Diabetic Foot / Q000601:surgery / Q000628:therapy; D053595:Embryonic Stem Cells / Q000637:transplantation; D042783:Endothelial Cells / Q000166:cytology; D015316:Genetic Therapy; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000637:transplantation; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D007511:Ischemia / Q000601:surgery / Q000628:therapy; D007866:Leg / Q000098:blood supply; D045164:Mesenchymal Stem Cell Transplantation; D051379:Mice; D015337:Multicenter Studies as Topic; D058729:Peripheral Arterial Disease / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D043925:Angiogenesis Inducing Agents; D036341:Intercellular Signaling Peptides and Proteins; D011994:Recombinant Proteins