title: Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry.
authors.affiliation: Department of Biochemistry, University of Illinois, Urbana, IL 61801, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Gregory
authors.forename: Piotr J
authors.initials: PJ
authors.lastname: Mak
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Sligar
authors.forename: James R
authors.initials: JR
authors.lastname: Kincaid
mesh_terms: D006907:17-alpha-Hydroxypregnenolone / Q000737:chemistry*; D019326:17-alpha-Hydroxyprogesterone / Q000737:chemistry*; D000735:Androstenedione / Q000096:biosynthesis; D055162:Biocatalysis; D053898:Biosynthetic Pathways; D019755:Carbon-Carbon Lyases / Q000737:chemistry* / Q000235:genetics; D003687:Dehydroepiandrosterone / Q000096:biosynthesis; D006801:Humans; D006860:Hydrogen Bonding; D006900:Hydroxylation; D010084:Oxidation-Reduction; D013059:Spectrum Analysis, Raman; D013254:Steroid 17-alpha-Hydroxylase / Q000737:chemistry* / Q000235:genetics; D013379:Substrate Specificity
chemical_list: D006907:17-alpha-Hydroxypregnenolone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D019326:17-alpha-Hydroxyprogesterone; C501892:CYP17A1 protein, human; D013254:Steroid 17-alpha-Hydroxylase; D019755:Carbon-Carbon Lyases