title: Pollinex Quattro: an innovative four injections immunotherapy in allergic rhinitis.
abstract: The prevalence of seasonal allergic rhinitis in the western world is high and increasing. Besides considerably affecting physical and psychosocial aspects of patients' lives, allergic rhinitis is often associated with allergic asthma and may aggravate this condition over time. Specific immunotherapy is currently the only approved therapy that can modify the underlying disease process and induce long-term tolerance to allergens. Pollinex Quattro is a subcutaneous four injections immunotherapy consisting of tyrosine-absorbed specific allergoids and enhanced with the adjuvant monophosphoryl lipid A (MPL(®)). MPL(®) induces a significant Th 1-type immune response, characterized by an increase of allergen-specific IgG antibody levels and dampening of the IgE response during allergen exposure. Due to this dual action of stimulating the immune system, Pollinex Quattro is clinically effective after only four injections given pre-seasonally. A large clinical program has demonstrated efficacy and tolerability of Pollinex Quattro in children, adolescents and adults with grass and tree pollen allergy. A health economics study concluded that an immunotherapy with only 4 injections might be more cost-beneficial than other application forms of immunotherapy.
authors.affiliation: Pädiatrische Allergologie; Pneumologie und Mukoviszidose; Klinik für Kinder- und Jugendmedizin; Johann Wolfgang Goethe-Universität; Frankfurt am Main, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Rosewich
authors.forename: Denise
authors.initials: D
authors.lastname: Lee
authors.forename: Stefan
authors.initials: S
authors.lastname: Zielen
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000485:Allergens / Q000276:immunology; D003888:Desensitization, Immunologic; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D007167:Immunotherapy / Q000379:methods*; D008050:Lipid A / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000276:immunology; D006109:Poaceae / Q000276:immunology; D011058:Pollen / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*; D051193:Toll-Like Receptors / Q000276:immunology; D014612:Vaccines / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D000276:Adjuvants, Immunologic; D000485:Allergens; D007074:Immunoglobulin G; D008050:Lipid A; C516537:Pollinex Quattro; D051193:Toll-Like Receptors; D014612:Vaccines; D007073:Immunoglobulin E; C048436:monophosphoryl lipid A
keywords: SCIT; allergoid; allergy; immunotherapy; mpl; rhinitis; vaccine