title: Long-term health and development of children diagnosed prenatally with a de novo apparently balanced chromosomal rearrangement.
abstract: OBJECTIVE
  This study aimed to determine if liveborn children with prenatally detected de novo apparently balanced chromosome rearrangements (ABCR) have more long-term health, developmental or behavioural concerns compared with children in a normal Australian population.
  
  
  METHODS
  This was a retrospective ascertainment of all liveborn children with prenatally detected de novo ABCRs in two Australian states over a 10-year period (1994-2003). Child health, development and behaviour were assessed by maternal report using standardised measures; educational ability and achievement were measured by direct child assessment. Data were compared with relevant population norms, and one sample t-test performed to test for statistical differences.
  
  
  RESULTS
  Of 39 eligible cases, 16 (41%) participated in the study. One child (6%) was born with a congenital anomaly, and two children (12.5%) reported a chronic health concern. Compared with population norms, no significant differences were observed with respect to intelligence, mental health, child development and educational ability; children had significantly higher scores indicative of better functioning on bodily pain, social-emotional behaviour and physical functioning. No child satisfied the criteria for having a special health care need.
  
  
  CONCLUSIONS
  Children in this study with a prenatally detected de novo ABCR have similar long-term health, developmental and behavioural outcomes compared with population norms.
authors.affiliation: School of Women's and Children's Health, University of New South Wales, Kensington, NSW, 2051, Australia. Ingrid.sinnerbrink@swahs.health.nsw.gov.au
authors.forename: Ingrid B
authors.initials: IB
authors.lastname: Sinnerbrink
authors.forename: Amanda
authors.initials: A
authors.lastname: Sherwen
authors.forename: Bettina
authors.initials: B
authors.lastname: Meiser
authors.forename: Jane
authors.initials: J
authors.lastname: Halliday
authors.forename: David J
authors.initials: DJ
authors.lastname: Amor
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Waters
authors.forename: Felicity
authors.initials: F
authors.lastname: Rea
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Evans
authors.forename: Belinda
authors.initials: B
authors.lastname: Rahman
authors.forename: Edwin P
authors.initials: EP
authors.lastname: Kirk
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000196:embryology; D005260:Female; D006262:Health; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011296:Prenatal Diagnosis / Q000706:statistics & numerical data; D012189:Retrospective Studies; D014178:Translocation, Genetic