title: Diamond-lipid hybrids enhance chemotherapeutic tolerance and mediate tumor regression.
abstract: Self-assembled nanodiamond-lipid hybrid particles (NDLPs) harness the potent interaction between the nanodiamond (ND)-surface and small molecules, while providing a mechanism for cell-targeted imaging and therapy of triple negative breast cancers. Epidermal growth factor receptor-targeted NDLPs are highly biocompatible particles that provide cell-specific imaging, promote tumor retention of ND-complexes, prevent epirubicin toxicities and mediate regression of triple negative breast cancers.
authors.affiliation: Department of Biomedical Engineering Northwestern University Evanston, Illinois, 60208, USA.
authors.forename: Laura K
authors.initials: LK
authors.lastname: Moore
authors.affiliation: George Williams Hooper Foundation University of California San Francisco San Francisco, California, 94143, USA.
authors.forename: Edward K
authors.initials: EK
authors.lastname: Chow
authors.affiliation: NanoCarbon Research Institute Shinshu University Ueda, Nagano, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Osawa
authors.affiliation: Department of Microbiology and Immunology George Williams Hooper Foundation University of California San Francisco San Francisco, California, 94143, USA.
authors.forename: J Michael
authors.initials: JM
authors.lastname: Bishop
authors.affiliation: Department of Biomedical Engineering Northwestern University Evanston, Illinois, 60208, USA ;Mechanical Engineering Northwestern University Evanston, Illinois, 60208, USA; Institute for Bionanotechnology in Medicine (IBNAM) Robert H. Lurie Comprehensive Cancer Center Northwestern University Chicago. Illinois, 60611, USA.
authors.forename: Dean
authors.initials: D
authors.lastname: Ho
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D004361:Drug Tolerance; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D051379:Mice; D058612:Nanodiamonds / Q000737:chemistry*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D008055:Lipids; D058612:Nanodiamonds; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: cancer; drug delivery; hybrid nanomaterials; nanodiamond; nanomedicine