title: Recovery from slow inactivation of Shab K(+) channels.
abstract: We have recently examined slow inactivation of Shab channels. Here we extend our characterization of Shab slow inactivation by presenting the properties of recovery from inactivation. The observations support our proposal that Shab reaches the same inactivated state either from open or closed states and suggest that closed and open state inactivation share the same mechanism. Regarding the latter, we also show that external K (+) and TEA slow down recovery from inactivation in agreement with the hypothesis that the mechanism of Shab inactivation qualitatively differs from C-type inactivation.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, México D.F., México.
authors.forename: Imilla I
authors.initials: II
authors.lastname: Arias-Olguín
authors.forename: Elisa
authors.initials: E
authors.lastname: Carrillo
authors.forename: Leon D
authors.initials: LD
authors.lastname: Islas
authors.forename: Froylan
authors.initials: F
authors.lastname: Gómez-Lagunas
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D011689:Purkinje Cells / Q000378:metabolism*; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel; D009569:Nitric Oxide; D002118:Calcium
keywords: Drosophila; Shab K+ channels; U-type inactivation; slow inactivation