title: Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia.
abstract: BACKGROUND
  Association of rs1344706 in the ZNF804A gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases. Subsequently, evidence by replication was obtained in several samples with European- and Asian ancestral background.
  
  
  METHODS
  We report ascertainment, clinical characterization, quality control, and determination of ancestral background of a case control sample from Indonesia, comprising 1067 cases and 1111 ancestry matched controls. Genotyping was performed using a fluorescence-based allelic discrimination assay (TaqMan SNP genotyping assay) and a newly designed PCR-RFLP assay for confirmation of rs1344706 genotypes.
  
  
  RESULTS
  We confirmed association of the T-allele of rs1344706 with schizophrenia in a newly ascertained sample from Indonesia with Southeast Asian ancestral background (P=0.019, OR=1.155, 95%, CI 1.025-1.301). In addition, we studied several SNPs in the vicinity of rs1344706, for which nominally significant results had been reported. None of the association P values of the additional SNPs exceeded that of rs1344706.
  
  
  CONCLUSIONS
  We provide additional evidence for association of the ZNF804A gene with schizophrenia. We conclude that rs1344706 or a yet unknown polymorphism in linkage disequilibrium is also involved in conferring susceptibility to schizophrenia in samples with different (Asian) ancestral backgrounds.
authors.affiliation: Department of Psychiatry and Psychotherapy, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: sibylle.schwab@uk-erlangen.de.
authors.forename: Sibylle G
authors.initials: SG
authors.lastname: Schwab
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Agung A A A
authors.initials: AAAA
authors.lastname: Kusumawardhani
authors.affiliation: Western Australian Institute for Medical Research & Centre for Medical Research, University of Western Australia, Nedlands, Australia; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia.
authors.forename: Nan
authors.initials: N
authors.lastname: Dai
authors.affiliation: Western Australian Institute for Medical Research & Centre for Medical Research, University of Western Australia, Nedlands, Australia; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia.
authors.forename: WenWen
authors.initials: W
authors.lastname: Qin
authors.affiliation: Western Australian Institute for Medical Research & Centre for Medical Research, University of Western Australia, Nedlands, Australia; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia.
authors.forename: Mutiara D B
authors.initials: MDB
authors.lastname: Wildenauer
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Feranindhya
authors.initials: F
authors.lastname: Agiananda
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Nurmiati
authors.initials: N
authors.lastname: Amir
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Ronald
authors.initials: R
authors.lastname: Antoni
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Tiana
authors.initials: T
authors.lastname: Arsianti
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Asmarahadi
authors.initials: A
authors.lastname: Asmarahadi
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Hervita
authors.initials: H
authors.lastname: Diatri
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Prianto
authors.initials: P
authors.lastname: Djatmiko
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Irmansyah
authors.initials: I
authors.lastname: Irmansyah
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Siti
authors.initials: S
authors.lastname: Khalimah
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Irmia
authors.initials: I
authors.lastname: Kusumadewi
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Profitasari
authors.initials: P
authors.lastname: Kusumaningrum
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Petrin R
authors.initials: PR
authors.lastname: Lukman
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Lukman
authors.initials: L
authors.lastname: Mustar
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Martina W
authors.initials: MW
authors.lastname: Nasrun
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Safyuni
authors.initials: S
authors.lastname: Naswati
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Prasetiyawan
authors.initials: P
authors.lastname: Prasetiyawan
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Gerald M
authors.initials: GM
authors.lastname: Semen
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Kristiana
authors.initials: K
authors.lastname: Siste
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Heriani
authors.initials: H
authors.lastname: Tobing
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Natalia
authors.initials: N
authors.lastname: Widiasih
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Tjhin
authors.initials: T
authors.lastname: Wiguna
authors.affiliation: Department of Psychiatry, University of Indonesia, Jakarta, Indonesia.
authors.forename: Widayanti Dewi
authors.initials: WD
authors.lastname: Wulandari
authors.affiliation: Queensland Brain Institute, University of Queensland, St. Lucia, Australia.
authors.forename: Beben
authors.initials: B
authors.lastname: Benyamin
authors.affiliation: Western Australian Institute for Medical Research & Centre for Medical Research, University of Western Australia, Nedlands, Australia; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Australia; Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, Claremont, Australia.
authors.forename: Dieter B
authors.initials: DB
authors.lastname: Wildenauer
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007214:Indonesia; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D051741:Kruppel-Like Transcription Factors; C540527:ZNF804A protein, human