title: 4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel.
abstract: Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA. george.p.lahm@dupont.com
authors.forename: George P
authors.initials: GP
authors.lastname: Lahm
authors.forename: Daniel
authors.initials: D
authors.lastname: Cordova
authors.forename: James D
authors.initials: JD
authors.lastname: Barry
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Pahutski
authors.forename: Ben K
authors.initials: BK
authors.lastname: Smith
authors.forename: Jeffrey K
authors.initials: JK
authors.lastname: Long
authors.forename: Eric A
authors.initials: EA
authors.lastname: Benner
authors.forename: Caleb W
authors.initials: CW
authors.lastname: Holyoke
authors.forename: Kathleen
authors.initials: K
authors.lastname: Joraski
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.forename: Mark E
authors.initials: ME
authors.lastname: Schroeder
authors.forename: Ty
authors.initials: T
authors.lastname: Wagerle
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Mahaffey
authors.forename: Rejane M
authors.initials: RM
authors.lastname: Smith
authors.forename: My-Hahn
authors.initials: MH
authors.lastname: Tong
mesh_terms: D000818:Animals; D018118:Chloride Channels / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007313:Insecta; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D018079:Receptors, GABA / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: C584282:4-azolylphenyl isoxazoline; D018118:Chloride Channels; D007306:Insecticides; D007555:Isoxazoles; D018079:Receptors, GABA