title: Amelioration of hepatotoxicity induced by aflatoxin using citrus fruit oil in broilers (Gallus domesticus).
abstract: This study was conducted to evaluate the efficacy of citrus fruit oil (CFO; 2.5 g kg(-1)) on the clinicopathological changes in broilers fed with diets containing 1 ppm of aflatoxin (AF). A total of 160 Ross 308 broiler chicks of 1-day-old were procured from a commercial hatchery, divided randomly on 7th day of age into four groups with two replicates of 20 birds each and fed with basal diet (group A), basal diet + CFO (group B), basal diet + AF (group C) and CFO + basal diet + AF (group D). The gross and histopathological changes in the liver, kidney, spleen, thymus and bursa of Fabricius were investigated and relative organ weights were calculated. Slight to moderate hydropic degeneration, fatty change with the formation of cyst in some cases, periportal necrosis, infiltration of heterophils and mononuclear cells and bile duct hyperplasia were observed in chicks fed with 1 ppm AF-containing diet. The addition of CFO to AF-containing diet moderately decreased the magnitude and severity of lesions (hydropic degeneration and bile duct hyperplasia) in the liver. The supplementation of CFO to the basal diet did not produce any adverse effects in birds.
authors.affiliation: Department of Veterinary Pathology, Veterinary College, Bangalore, Karnataka, India senvetpath@gmail.com.
authors.forename: D Senthil
authors.initials: DS
authors.lastname: Kumar
authors.affiliation: Department of Veterinary Pathology, Veterinary College, Bangalore, Karnataka, India.
authors.forename: Suguna
authors.initials: S
authors.lastname: Rao
authors.affiliation: Department of Veterinary Pathology, Veterinary College, Bangalore, Karnataka, India.
authors.forename: M L
authors.initials: ML
authors.lastname: Satyanarayana
authors.affiliation: Department of Veterinary Pathology, Veterinary College, Bangalore, Karnataka, India.
authors.forename: P G Pradeep
authors.initials: PG
authors.lastname: Kumar
authors.affiliation: Department of Veterinary Pathology, Veterinary College, Bangalore, Karnataka, India.
authors.forename: N
authors.initials: N
authors.lastname: Anitha
mesh_terms: D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D002060:Bursa of Fabricius / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D002645:Chickens; D002957:Citrus / Q000737:chemistry*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010938:Plant Oils / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
chemical_list: D000348:Aflatoxins; D010938:Plant Oils
keywords: Aflatoxicosis; amelioration; broilers; citrus fruit oil; feed