title: Fragile X mental retardation protein and synaptic plasticity.
abstract: Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.
authors.affiliation: The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 46-3301, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Sidorov
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Auerbach
authors.forename: Mark F
authors.initials: MF
authors.lastname: Bear
mesh_terms: D000818:Animals; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000378:metabolism*; D006801:Humans; D007858:Learning / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology; D009473:Neuronal Plasticity; D014176:Protein Biosynthesis; D013569:Synapses / Q000378:metabolism*
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1