title: Risk factors for prolonged ileus after resection of colorectal cancer: an observational study of 2400 consecutive patients.
abstract: OBJECTIVE
  Prolonged ileus-the failure of postoperative ileus to resolve within a few days after major abdominal surgery-leads to significant medical consequences for the patient and costs to the hospital system. The aim of this retrospective analysis of prospectively collected data was to identify independent preoperative and intraoperative risk factors for prolonged ileus in a large consecutive series of patients who had undergone resection for colorectal cancer.
  
  
  METHODS
  Patients were drawn from a hospital registry of 2400 consecutive resections over the period 1995-2009. Thirty-four potential predictors of prolonged ileus were analyzed by logistic regression.
  
  
  RESULTS
  Prolonged ileus occurred in 14.0% of patients. Statistically significant independent predictors of prolonged ileus were male sex (OR: 1.7, P < 0.001), peripheral vascular disease (OR: 1.8, P < 0.001), respiratory comorbidity (OR: 1.6, P < 0.001), resection at urgent operation (OR: 2.2, P < 0.001), perioperative transfusion (OR: 1.6, P < 0.010), stoma constructed (OR: 1.4, P < 0.001), and operation lasting ≥3 hours (OR: 1.6, P < 0.001).
  
  
  CONCLUSIONS
  These features can be used to alert medical and nursing staff to patients likely to experience prolonged ileus after bowel resection so that they can be monitored closely in the postoperative period and available treatments targeted toward them. These features may also be useful in the research context to facilitate the more efficient selection of high-risk patients as subjects in clinical trials of prevention or treatment.
authors.affiliation: Department of Colorectal Surgery, Concord Hospital, New South Wales, Australia.
authors.forename: Pierre H
authors.initials: PH
authors.lastname: Chapuis
authors.forename: Les
authors.initials: L
authors.lastname: Bokey
authors.forename: Anil
authors.initials: A
authors.lastname: Keshava
authors.forename: Matthew J F X
authors.initials: MJ
authors.lastname: Rickard
authors.forename: Peter
authors.initials: P
authors.lastname: Stewart
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Young
authors.forename: Owen F
authors.initials: OF
authors.lastname: Dent
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D045823:Ileus / Q000453:epidemiology / Q000209:etiology*; D053208:Kaplan-Meier Estimate; D007902:Length of Stay / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D012007:Rectum / Q000601:surgery*; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome