title: Paper-based SlipPAD for high-throughput chemical sensing.
abstract: We report a paper analytical device (PAD) that is based on the SlipChip concept. This SlipPAD enables robust, high-throughput, multiplexed sensing while maintaining the extreme simplicity of paper-based analysis. The SlipPAD is comprised of two wax-patterned paper fluidic layers. By slipping one layer relative to the other, solutions wick simultaneously into a large array of sensing reservoirs or sequentially into a large array of channels to carry out homogeneous or heterogeneous assays, respectively. The applicability of the device to high-throughput multiplex chemical analysis is demonstrated by colorimetric and fluorescent assays.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Richard M
authors.initials: RM
authors.lastname: Crooks
mesh_terms: D003124:Colorimetry; D057166:High-Throughput Screening Assays / Q000295:instrumentation*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D010209:Paper; D013050:Spectrometry, Fluorescence