title: Differential expression of serum glycodelin and insulin-like growth factor binding protein 1 in early pregnancy.
abstract: This prospective study evaluated whether serum glycodelin and insulin-like growth factor binding protein 1 (IGFBP-1) predict the likelihood of embryo implantation in recipients undergoing donor egg in vitro fertilization. We measured glycodelin and IGFBP-1 at 6 points from lining check to lutenizing hormone (LH) + 31. β-Human chorionic gonadotropin levels were first measured at LH + 17. The recipients were divided into those without embryo implantation (group 1, n = 6) and those with successful implantation (group 2, n = 30). Although this is a negative study in that neither glycodelin nor IGFBP-1 alone reflected endometrial (EM) receptivity, the glycodelin/IGFBP-1 ratio on the day of blastocyst transfer was higher in recipients who achieved pregnancy (P = .05). At LH + 17, glycodelin was higher (P = .04), and IGFBP-1 was lower (P = .004) in recipients who achieved pregnancy when compared to those who did not. These observations are likely due to EM changes induced by successful embryo implantation.
authors.affiliation: 1Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA.
authors.forename: Nataki C
authors.initials: NC
authors.lastname: Douglas
authors.forename: Melvin H
authors.initials: MH
authors.lastname: Thornton
authors.forename: Sahadat K
authors.initials: SK
authors.lastname: Nurudeen
authors.forename: Maria
authors.initials: M
authors.lastname: Bucur
authors.forename: Rogerio A
authors.initials: RA
authors.lastname: Lobo
authors.forename: Mark V
authors.initials: MV
authors.lastname: Sauer
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium / Q000378:metabolism*; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D000071816:Glycodelin; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D008875:Middle Aged; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000097:blood; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D006063:Chorionic Gonadotropin; D000071816:Glycodelin; D006023:Glycoproteins; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; C045246:PAEP protein, human; D011374:Progesterone; D004958:Estradiol
keywords: IGFBP-1; glycodelin; implantation; in vitro fertilization; pregnancy