title: Tert-butylhydroquinone reduces lipid accumulation in C57BL/6 mice with lower body weight gain.
abstract: tert-Butylhydroquinone (tBHQ) is a commonly used antioxidant additive that is approved for human use by both the Food and Agriculture Organization and the World Health Organization (FAO/WHO). In this study, we examined the effect of tBHQ on body weight gain and found that food supplementation with 0.001 % (w/w) tBHQ inhibited 61.4 % (P < 0.01) of body weight gain in high-fat diet (HFD)-induced C57BL/6 mice, and the oral administration of tBHQ (1.5 mg/kg) reduced 47.5 % (P < 0.05) of body weight gain in normal diet fed db/db mice. The HFD increased lipid deposit in adipocytes, but these were reduced significantly by tBHQ treatment in C57BL/6 mice. tBHQ supplementation significantly lowered the plasma triglyceride and total cholesterol, with reduced size of accumulated fat mass. The rate limiting enzyme of beta-oxidation (ACOX1) was significantly over-expressed in the liver with tBHQ treatment. These results indicate that tBHQ suppresses body weight gain in mice, possibly at least related to the up-regulation of ACOX1 gene expression.
authors.affiliation: Office of Industrial Cooperation, Soonchunhyang University, Chungnam, Asan, 350-646, Republic of Korea. kwnam1@sch.ac.kr
authors.forename: Kung-Woo
authors.initials: KW
authors.lastname: Nam
authors.forename: Yong Hyun
authors.initials: YH
authors.lastname: Kim
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Sang-Ki
authors.initials: SK
authors.lastname: Rhee
authors.forename: Wan-Jong
authors.initials: WJ
authors.lastname: Kim
authors.forename: Man-Deuk
authors.initials: MD
authors.lastname: Han
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000009:adverse effects / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects* / Q000502:physiology; D059305:Diet, High-Fat / Q000379:methods; D006873:Hydroquinones / Q000009:adverse effects / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects* / Q000502:physiology; D008113:Liver Neoplasms / Q000139:chemically induced / Q000175:diagnosis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011897:Random Allocation; D015430:Weight Gain / Q000187:drug effects* / Q000502:physiology
chemical_list: D000975:Antioxidants; D006873:Hydroquinones; C018855:2-tert-butylhydroquinone