title: Contribution of endothelial precursors of adipose tissue to breast cancer: progression-link with fat graft for reconstructive surgery.
abstract: Obesity, an excess accumulation of adipose tissue occurring in mammalians when caloric intake exceeds energy expenditure, is associated with an increased frequency and progression of several types of neoplastic diseases including postmenopausal breast cancer. Recent studies have suggested that obesity-related disruption of the energy homeostasis results in inflammation and alterations of adipokine signalling that may foster cancer initiation and progression. Moreover, two populations of human white adipose tissue (WAT) progenitors cooperate in breast cancer angiogenesis, growth and metastatic progression. This raises the issue of lipotransfer in patients undergoing plastic or reconstructive surgery.
authors.affiliation: Departments of Pathology and Medecine, Laboratory of Hematology-Oncology, via Ripamonti 435, 20141 Milan, Italy. francesco.bertolini@ieo.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertolini
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000502:physiology* / Q000637:transplantation*; D000818:Animals; D001943:Breast Neoplasms / Q000209:etiology* / Q000473:pathology; D018450:Disease Progression; D042783:Endothelial Cells / Q000502:physiology*; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000009:adverse effects* / Q000379:methods; D013234:Stem Cells / Q000502:physiology*; D013997:Time Factors