title: The role of selected factors in the development and consequences of alcohol dependence.
abstract: Gender, family history, comorbid psychiatric and substance use disorders, and age all influence a person's risk for alcoholism. In addition, these factors interact with alcoholism to influence neurocognitive functioning following detoxification. This article examines these factors and considers how they interact with each other. This complexity reinforces the need for both animal and human studies and suggests multiple factors that may be sensitive to differential prevention, intervention, and treatment efforts. Thus, it is imperative that hypothesis-driven research designs be directed to identifying the relative potency of these factors and their interactions.
authors.affiliation: Division of Clinical Addiction Research, Department of Psychiatry, University of Florida, Gainesville, Florida.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Gilbertson
authors.forename: Robert
authors.initials: R
authors.lastname: Prather
authors.forename: Sara Jo
authors.initials: SJ
authors.lastname: Nixon
mesh_terms: D000367:Age Factors; D000437:Alcoholism / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D004200:Diseases in Twins / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology*; D012307:Risk Factors; D012737:Sex Factors