title: Benzophenones from an endophytic fungus, Graphiopsis chlorocephala, from Paeonia lactiflora cultivated in the presence of an NAD+-dependent HDAC inhibitor.
abstract: Graphiopsis chlorocephala was separated from the surface-sterilized healthy leaves of Paeonia lactiflora (Paeoniaceae) and cultivated with nicotinamide (an NAD(+)-dependent HDAC inhibitor). The culture conditions significantly enhanced secondary metabolite production in the fungus and led to the isolation of a structurally diverse set of new benzophenones, cephalanones A-F (1-6), and a known 2-(2,6-dihydroxy-4-methylbenzoyl)-6-hydroxybenzoic acid (7). The structures of 1-6 were determined from NMR data, single crystal X-ray diffraction, and chemical transformations.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Aoba-ku, Sendai 980-8578, Japan. tasai@m.tohoku.ac.jp
authors.forename: Teigo
authors.initials: T
authors.lastname: Asai
authors.forename: Sae
authors.initials: S
authors.lastname: Otsuki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sakurai
authors.forename: Kouwa
authors.initials: K
authors.lastname: Yamashita
authors.forename: Tomoji
authors.initials: T
authors.lastname: Ozeki
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Oshima
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D008968:Molecular Conformation; D009243:NAD; D009536:Niacinamide / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D029596:Paeonia / Q000382:microbiology*; D018515:Plant Leaves / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001577:Benzophenones; D056572:Histone Deacetylase Inhibitors; D009243:NAD; D009536:Niacinamide