title: [Promotion of compound fujian tablet on the motor function rehabilitation and neurotization in rats with cerebral infarction].
abstract: OBJECTIVE
  To study the effects of Compound Fujian Tablet (FJT)on the neurotization in the cerebral infarction rats and to explore its mechanisms for promoting the motor skills.
  
  
  METHODS
  Totally 90 Wistar rats were randomly divided into the drug group, the model group, and the sham-operation group, 30 in each group. The rat model of middle cerebral artery occlusion (MCAO) was successfully established by electrocoagulation. Six hours after successful modeling, the rats of the drug group were orally administered with 9 g/kg FJT water solution, and the other groups were orally administered with equal volume of normal saline, once a day for two weeks. The motor skills of rats were examined by beam walking test. The expressions of nestin, polysialic acid neural cell adhesion molecule (PSA-NCAM), microtubule-associated protein 2 (MAP-2), growth-associated protein (GAP-43), and synaptophysin (Syn) in the brain tissue around the infarction were observed by in immunohistochemical assay. The mean staining gray or the optical density value were detected.
  
  
  RESULTS
  The 86 rats were recruited in the result analysis. After two weeks of administration, the neural function scoring was obviously higher in the drug group than in the model group with statistical difference (P < 0.01). The expressions of nestin, PSA-NCAM, MAP-2, GAP-43, and Syn in the brain tissue around the infarction were more obviously enhanced in the drug group than in the model group, showing statistical difference (P < 0.01).
  
  
  CONCLUSIONS
  FJT can promote neurotization and improve the motor skill recovery after cerebral infarction.
authors.affiliation: Department of Traditional Chinese Medicine, Medical College of Qingdao University, Qingdao 266021, China. doctorzyh@yahoo.com.cn
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Zhou
authors.forename: Huai-Qiang
authors.initials: HQ
authors.lastname: Hu
authors.forename: Xin-Lu
authors.initials: XL
authors.lastname: Wang
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002544:Cerebral Infarction / Q000534:rehabilitation*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D019922:GAP-43 Protein / Q000378:metabolism; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009048:Motor Skills / Q000187:drug effects*; D009416:Nerve Regeneration; D064231:Nestin / Q000378:metabolism; D039842:Neural Cell Adhesion Molecule L1 / Q000378:metabolism; D008517:Phytotherapy; D051381:Rats; D017208:Rats, Wistar; D012794:Sialic Acids / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D019922:GAP-43 Protein; C489787:MAP2 protein, rat; D008869:Microtubule-Associated Proteins; C577486:Nes protein, rat; D064231:Nestin; D039842:Neural Cell Adhesion Molecule L1; D012794:Sialic Acids; D016708:Synaptophysin; C569016:Syp protein, rat; C103469:polysialyl neural cell adhesion molecule