title: Genetic variation in the fat mass and obesity-associated gene (FTO) in association with food preferences in healthy adults.
abstract: BACKGROUND
  Earlier studies have indicated that the fat mass and obesity-associated gene (FTO) is not only associated with BMI and weight but also with appetite and dietary intake.
  
  
  OBJECTIVE
  We investigated if the FTO rs9939609 associates with food preferences in healthy adults with no cancer, cardiovascular disease, or diabetes. Additionally, we challenged the question if the associations are modified by obesity status (BMI ≤25 or >25 kg/m(2)).
  
  
  METHODS
  The analyses are made with 22,799 individuals from the Swedish population-based Malmö Diet and Cancer Cohort Study, who were born between 1923 and 1945. To investigate food preference, 27 food groups conducted from a modified diet history method including a 7-day registration of cooked meals and cold beverages were used in the analyses. Bonferroni correction was used to correct for multiple testing, resulting in a cut-off value for significance level of p<0.002.
  
  
  RESULTS
  We observed that the obesity susceptible A-allele carriers reported a higher consumption of biscuits and pastry but lower consumption of soft drinks (P for trend <0.0001 for both) as compared to TT genotype carriers. In contrast to our hypothesis, the results did not significantly differ depending on obesity status except for consumption of juice, where only the overweight individuals with A-allele had a higher consumption as compared to TT carriers (P for interaction=0.04).
  
  
  CONCLUSIONS
  Our results indicate that the FTO A-allele may associate with certain food preference and in particular with certain energy-dense foods.
authors.affiliation: Diabetes and Cardiovascular Disease - Genetic Epidemiology, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
authors.forename: Louise
authors.initials: L
authors.lastname: Brunkwall
authors.forename: Ulrika
authors.initials: U
authors.lastname: Ericson
authors.forename: Sophie
authors.initials: S
authors.lastname: Hellstrand
authors.forename: Bo
authors.initials: B
authors.lastname: Gullberg
authors.forename: Marju
authors.initials: M
authors.lastname: Orho-Melander
authors.forename: Emily
authors.initials: E
authors.lastname: Sonestedt
keywords: Sweden; adults; food preference; genetic; nutrition intake; obesity