title: Direct Renin inhibitor: aliskiren in chronic kidney disease.
abstract: The renin-angiotensin-aldosterone system (RAAS) plays pivotal roles in the pathogenesis of chronic kidney disease (CKD) progression and its increased complications such as hypertension (HT) and cardiovascular diseases (CVD). Previous studies suggested that aliskiren a direct renin inhibitor, blocks RAAS and may be effective for the management of CKD and its complications. This review focuses on the effects of aliskiren on CKD.
authors.affiliation: Division of Nephrology, Department of Medicine, Jichi Medical University, Tochigi, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Morishita
authors.forename: Eiji
authors.initials: E
authors.lastname: Kusano
keywords: Aliskiren; Blood Pressure; Cardiovascular Diseases; Kidney Failure, Chronic; Renin-Angiotensin System