title: Safety evaluation of desloratadine in allergic rhinitis.
abstract: BACKGROUND
  Desloratadine is a biologically active metabolite of second-generation antihistamine loratadine. It is also indicated for the treatment of allergic diseases, including allergic rhinitis.
  
  
  METHODS
  A Medline search was conducted to identify preclinical and clinical studies of desloratadine. This was supplemented with additional articles obtained from online sources. The focus of this review is on the safety profile of desloratadine.
  
  
  CONCLUSIONS
  The review of these data indicates that the safety profile of desloratadine is similar to other second-generation antihistamines. Desloratadine is highly selective for histamine H₁-receptors, does not cross the blood-brain barrier (BBB), and has minimal adverse events (very low sedation rate), with a better safety and tolerability than first-generation antihistamines. Desloratadine is safe and well tolerated without having central nervous system (CNS) or cardiovascular effects and with low drug interaction.
authors.affiliation: Hospital Quirón, Department of Allergology, Barcelona, Catalonia, Spain.
authors.forename: Vanesa
authors.initials: V
authors.lastname: González-Núñez
authors.forename: Antonio
authors.initials: A
authors.lastname: Valero
authors.forename: Joaquim
authors.initials: J
authors.lastname: Mullol
mesh_terms: D039563:Histamine H1 Antagonists, Non-Sedating / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D017336:Loratadine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*
chemical_list: D039563:Histamine H1 Antagonists, Non-Sedating; D017336:Loratadine; C121345:desloratadine