title: Ruthenium-catalyzed intramolecular hydrocarbamoylation of allylic formamides: convenient access to chiral pyrrolidones.
abstract: An attractive strategy for the synthesis of saturated nitrogen-containing heterocycles is described herein, involving the implementation of ruthenium-catalyzed intramolecular hydrocarbamoylation of olefins. The process proceeds by formal C-H bond cleavage of an allylic formamide followed by construction of a new C-C bond in a reaction that is characterized by complete atom-economy. The method is particularly valuable in conjunction with the numerous efficient strategies available for the preparation of optically active allylic formamides.
authors.affiliation: Laboratorium für Organische Chemie, ETH Zürich, Zürich, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Armanino
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D005559:Formamides / Q000737:chemistry*; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000498:Allyl Compounds; D005559:Formamides; D011760:Pyrrolidinones; D012428:Ruthenium