title: Expression of sPLA2-V, estrogen and its target protein in myocardium tissue.
abstract: In this study, we examined the effects of Prostaglandin E1 and tea polysaccharides (TP) on serum estrogen and FSH levels, myocardium sPLA2-V positive levels, and sPLA2-V protein expression in the rats fed on hypercholesterolemic diet. Hyperlipidemic rats were treated with Prostaglandin E1 and TP. Serum estrogen and FSH levels were significantly enhanced by Prostaglandin E1 and TP, whereas myocardium sPLA2-V positive rate and protein expression levels were decreased compared to the HCD group. Our results suggest that Prostaglandin E1 and TP exert strong heart-protective effects and therefore can be used to reduce the risk of heart disorders.
authors.affiliation: Department of Cardiology, Nanjing Drum Tower Clinical College, Nanjing Medical University, Nanjing 210008, China.
authors.forename: Jiangwei
authors.initials: J
authors.lastname: Ma
authors.forename: Zengyong
authors.initials: Z
authors.lastname: Qiao
authors.forename: Biao
authors.initials: B
authors.lastname: Xu
mesh_terms: D000527:Alprostadil / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D028241:Camellia sinensis / Q000737:chemistry; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use; D003327:Coronary Disease / Q000188:drug therapy / Q000209:etiology; D059305:Diet, High-Fat / Q000009:adverse effects; D004967:Estrogens / Q000097:blood*; D005640:Follicle Stimulating Hormone / Q000097:blood; D054505:Group V Phospholipases A2 / Q000378:metabolism*; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000737:chemistry
chemical_list: D002316:Cardiotonic Agents; D004967:Estrogens; D010936:Plant Extracts; D013662:Tea; D005640:Follicle Stimulating Hormone; D054505:Group V Phospholipases A2; D000527:Alprostadil