title: Ageing as a Trait de Union between diabetes and dementia for frailty.
abstract: A frail patient is one who carries a sum of poly-pathologies, whose co-existence may shorten his life expectation. Diabetes mellitus type 2 and metabolic syndrome play a substantial role in it, but dementia has increasingly risen in importance. Interestingly, the insulin pathway was suggested to be responsible for the metabolic cascade that leads to amyloid-beta deposit and pathology. Nevertheless, a clear relationship between them was just experimentally, rather than clinically demonstrated. In this work the authors suggest a possible link between insulin, diabetes and Alzheimer's disease, whose co-existence could be responsible for physical and cognitive decline but not for frailty. We suggest that these factors could be responsible for frailty only if senescence-associated.
authors.affiliation: ACISMOM Centro Diabetologico- Via LE Morselli, 13 00148 Roma, Italy. roberta.semprini@gmail.com
authors.forename: Roberta
authors.initials: R
authors.lastname: Semprini
authors.forename: Mauro
authors.initials: M
authors.lastname: Ragonese
authors.forename: Maurizio
authors.initials: M
authors.lastname: Poggi
authors.forename: Antonella
authors.initials: A
authors.lastname: Franze
authors.forename: Alessandro
authors.initials: A
authors.lastname: Martorana
mesh_terms: D000368:Aged; D000375:Aging; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology; D003704:Dementia / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology; D016330:Frail Elderly; D006801:Humans; D012307:Risk Factors
chemical_list: D016229:Amyloid beta-Peptides