title: A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide.
abstract: A small molecule, protein mimetic based approach is shown to specifically inhibit lipid catalysed self-assembly of islet amyloid polypeptide (IAPP). The lipid-bound oligomerization of this peptide is implicated in cellular dysfunction of insulin secreting β-cells in type II diabetes.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kumar
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Miranker
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry; D002462:Cell Membrane; D058228:Islet Amyloid Polypeptide / Q000737:chemistry*; D057786:Peptidomimetics; D034444:Peptoids / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry; D010715:Phosphatidylglycerols / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry
chemical_list: D002264:Carboxylic Acids; D058228:Islet Amyloid Polypeptide; D057786:Peptidomimetics; D034444:Peptoids; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D011804:Quinolines; C051388:1,2-dioleoyl-sn-glycero-3-phosphoglycerol; C017251:1,2-oleoylphosphatidylcholine