title: Role of saffron and its constituents on cancer chemoprevention.
abstract: BACKGROUND
  Cancer dramatically impacts human life expectancy and quality of life. Natural substances from vegetables, herbs and spices could be beneficial in the prevention or treatment of a variety of cancers. Crocus sativus (Iridaceae), which has been used as a folk medicine for treating diseases for ages, showed obvious cancer chemoprevention potential.
  
  
  OBJECTIVE
  This article focuses on the effects of Crocus sativus and its main ingredients, such as crocin, on cancer therapeutics.
  
  
  METHODS
  We reviewed research data from saffron, a spice derived from the flower of Crocus sativus, and its constituents using the major databases, namely, Web of Science, SciFinder and PubMed.
  
  
  CONCLUSIONS
  Saffron possesses free radical-scavenging properties and antitumor activities. Significant cancer chemopreventive effects have been shown in both in vitro and in vivo models. Based on current data, saffron and its ingredients could be considered as a promising candidate for clinical anticancer trials.
authors.affiliation: Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Zhang
authors.forename: Chong-Zhi
authors.initials: CZ
authors.lastname: Wang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Wen
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Shoyama
authors.forename: Chun-Su
authors.initials: CS
authors.lastname: Yuan
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D018890:Chemoprevention / Q000379:methods; D027622:Crocus / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008519:Medicine, Traditional; D009369:Neoplasms / Q000473:pathology / Q000517:prevention & control*; D010936:Plant Extracts / Q000494:pharmacology; D011788:Quality of Life
chemical_list: D016588:Anticarcinogenic Agents; D016166:Free Radical Scavengers; D010936:Plant Extracts