title: Endowing carbon nanotubes with superparamagnetic properties: applications for cell labeling, MRI cell tracking and magnetic manipulations.
abstract: Coating of carbon nanotubes (CNTs) with magnetic nanoparticles (NPs) imparts novel magnetic, optical, and thermal properties with potential applications in the biomedical domain. Multi-walled CNTs have been decorated with iron oxide superparamagnetic NPs. Two different approaches have been investigated based on ligand exchange or "click chemistry". The presence of the NPs on the nanotube surface allows conferring magnetic properties to CNTs. We have evaluated the potential of the NP/CNT hybrids as a contrast agent for magnetic resonance imaging (MRI) and their interactions with cells. The capacity of the hybrids to magnetically monitor and manipulate cells has also been investigated. The NP/CNTs can be manipulated by a remote magnetic field with enhanced contrast in MRI. They are internalized into tumor cells without showing cytotoxicity. The labeled cells can be magnetically manipulated as they display magnetic mobility and are detected at a single cell level through high resolution MRI.
authors.affiliation: CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, UPR 3572, 67000 Strasbourg, France.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lamanna
authors.forename: Antonio
authors.initials: A
authors.lastname: Garofalo
authors.forename: Gabriela
authors.initials: G
authors.lastname: Popa
authors.forename: Claire
authors.initials: C
authors.lastname: Wilhelm
authors.forename: Sylvie
authors.initials: S
authors.lastname: Bégin-Colin
authors.forename: Delphine
authors.initials: D
authors.lastname: Felder-Flesch
authors.forename: Alberto
authors.initials: A
authors.lastname: Bianco
authors.forename: Florence
authors.initials: F
authors.lastname: Gazeau
authors.forename: Cécilia
authors.initials: C
authors.lastname: Ménard-Moyon
mesh_terms: D045744:Cell Line, Tumor; D057930:Click Chemistry / Q000379:methods; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D060328:Magnetic Phenomena; D008279:Magnetic Resonance Imaging; D008297:Male; D008422:Materials Testing; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D011859:Radiography
chemical_list: D003287:Contrast Media; D037742:Nanotubes, Carbon