title: Malignant change in seborrhoeic keratoses in a region with high solar ultraviolet levels.
abstract: Regions with high solar UV levels and high skin cancer rates may experience a greater incidence of malignancy in association with seborrhoeic keratoses (SebK) than in low UV regions. Previous reports have indicated that basal cell carcinoma is the most common neoplasm with reported rates of up to 4 per cent of excised SebK. The rates of such compound lesions occurring in our practice were reviewed, indicating that Bowen's disease was the most frequently observed neoplasm with a rate of 7 per cent. In total, 10 per cent of all excised specimens showed either frank malignancy or some degree of atypia.
authors.affiliation: Department of Dermatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Gaffney
authors.forename: James B
authors.initials: JB
authors.lastname: Muir
authors.forename: Brian
authors.initials: B
authors.lastname: De'Ambrosis
mesh_terms: D001913:Bowen's Disease / Q000209:etiology / Q000473:pathology*; D002280:Basal Cell Carcinoma / Q000209:etiology / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects; D006801:Humans; D055623:Keratosis, Actinic / Q000473:pathology; D017492:Keratosis, Seborrheic / Q000473:pathology*; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D011793:Queensland; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
keywords: Bowen's disease; malignancy; seborrhoeic keratosis