title: [Spinal arthrodesis. basic science].
abstract: Spinal arthrodesis consists of a combination of a system of mechanical stabilisation of one or more vertebral segments with a biological substance that promotes osteoneogenesis, with aim of achieving the permanent fusion between areas more or less the same size of these segments. In spinal arthrodesis, the biological support par excellence is the autograft. However, obtaining this involves a high incidence of morbidity and, in cases of arthrodesis of more than one intervertebral space, the quantity available is usually insufficient. The extraction and implantation time prolongs the surgery, increasing the exposure to and risk of bleeding and infection. For these reasons, there is a search for substances that possess the properties of the autograft, avoiding the morbidity and added surgical time required to extract the autograft. The biomechanical-biological interaction in vertebral arthrodesis has been studied in this article.
authors.affiliation: Departamento de Cirugía Ortopédica y Traumatología, Hospital Costa del Sol, Universidad de Málaga, Marbella, Málaga, España. eguerado@hcs.es
authors.forename: E
authors.initials: E
authors.lastname: Guerado
authors.forename: T
authors.initials: T
authors.lastname: Andrist
authors.forename: J A
authors.initials: JA
authors.lastname: Andrades
authors.forename: L
authors.initials: L
authors.lastname: Santos
authors.forename: A
authors.initials: A
authors.lastname: Cerván
authors.forename: G
authors.initials: G
authors.lastname: Guerado
authors.forename: J
authors.initials: J
authors.lastname: Becerra
mesh_terms: D001696:Biomechanical Phenomena; D001861:Bone Regeneration; D018786:Bone Substitutes; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D010012:Osteogenesis; D013123:Spinal Fusion / Q000295:instrumentation / Q000379:methods*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D018786:Bone Substitutes