title: Strategies for local gene therapy of corneal allograft rejection.
abstract: Penetrating keratoplasty is the most common type of tissue transplant in humans. Irreversible immune rejection leads to loss of vision and graft failure. This complex immune response further predisposes future corneal transplants to rejection and failure. A diverse armamentarium of surgical and pharmacologic tools is available to improve graft survival. In this review, we will discuss the various gene therapeutic strategies aimed at potentiating the anterior chamber-associated immune deviation to extend graft survival.
authors.affiliation: The Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
authors.forename: Pho
authors.initials: P
authors.lastname: Nguyen
authors.forename: Samuel C
authors.initials: SC
authors.lastname: Yiu
mesh_terms: D064591:Allografts; D015316:Genetic Therapy / Q000379:methods*; D006084:Graft Rejection / Q000276:immunology / Q000628:therapy*; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D015948:Keratoplasty, Penetrating
keywords: Adenovirus; Corneal Transplant; Dendrimer; Gene Therapy; Immune Privilege; Neovascularization; Plasmid; Rejection