title: Phantom and mouse experiments of time-domain fluorescence tomography using total light approach.
abstract: Phantom and mouse experiments of time-domain fluorescence tomography were conducted to demonstrate the total light approach which was previously proposed by authors. The total light approach reduces the computation time to solve the forward model for light propagation. Time-resolved temporal profiles were acquired for cylindrical phantoms having single or double targets containing indocyanine green (ICG) solutions. The reconstructed images of ICG concentration reflected the true distributions of ICG concentration with a spatial resolution of about 10 mm. In vivo experiments were conducted using a mouse in which an ICG capsule was embedded beneath the skin in the abdomen. The reconstructed image of the ICG concentration again reflected the true distribution of ICG although artifacts due to autofluorescence appeared in the vicinity of the skin. The effectiveness of the total light approach was demonstrated by the phantom and mouse experiments.
authors.affiliation: Department of Mechanical Engineering and Intelligent Systems, University of Electro-Communications, 1-5-1 Chofuga-oka, Chofu, Tokyo 182-8585, Japan ; Currently with the Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.
authors.forename: Shinpei
authors.initials: S
authors.lastname: Okawa
authors.forename: Akira
authors.initials: A
authors.lastname: Yano
authors.forename: Kazuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Yohei
authors.initials: Y
authors.lastname: Mitsui
authors.forename: Masaki
authors.initials: M
authors.lastname: Yoshida
authors.forename: Masashi
authors.initials: M
authors.lastname: Takekoshi
authors.forename: Andhi
authors.initials: A
authors.lastname: Marjono
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hoshi
authors.forename: Ikuhiro
authors.initials: I
authors.lastname: Kida
authors.forename: Kazuto
authors.initials: K
authors.lastname: Masamoto
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yamada
keywords: (170.3880) Medical and biological imaging; (170.6280) Spectroscopy, fluorescence and luminescence