title: Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond.
abstract: Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and behavioral research. Physiological similarity to mammals, ease of genetic manipulations, sensitivity to pharmacological and genetic factors, robust behavior, low cost, and potential for high-throughput screening contribute to the growing utility of zebrafish models in this field. Understanding zebrafish behavioral phenotypes provides important insights into neural pathways, physiological biomarkers, and genetic underpinnings of normal and pathological brain function. Novel zebrafish paradigms continue to appear with an encouraging pace, thus necessitating a consistent terminology and improved understanding of the behavioral repertoire. What can zebrafish 'do', and how does their altered brain function translate into behavioral actions? To help address these questions, we have developed a detailed catalog of zebrafish behaviors (Zebrafish Behavior Catalog, ZBC) that covers both larval and adult models. Representing a beginning of creating a more comprehensive ethogram of zebrafish behavior, this effort will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebrafish neurobehavioral paradigms in their research. In addition, this glossary creates a framework for developing a zebrafish neurobehavioral ontology, ultimately to become part of a unified animal neurobehavioral ontology, which collectively will contribute to better integration of biological data within and across species.
authors.affiliation: Department of Pharmacology and Neuroscience Program, Tulane University Medical School, 1430 Tulane Avenue, New Orleans, LA 70112, USA. avkalueff@gmail.com
authors.forename: Allan V
authors.initials: AV
authors.lastname: Kalueff
authors.forename: Michael
authors.initials: M
authors.lastname: Gebhardt
authors.forename: Adam Michael
authors.initials: AM
authors.lastname: Stewart
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Cachat
authors.forename: Mallorie
authors.initials: M
authors.lastname: Brimmer
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Chawla
authors.forename: Cassandra
authors.initials: C
authors.lastname: Craddock
authors.forename: Evan J
authors.initials: EJ
authors.lastname: Kyzar
authors.forename: Andrew
authors.initials: A
authors.lastname: Roth
authors.forename: Samuel
authors.initials: S
authors.lastname: Landsman
authors.forename: Siddharth
authors.initials: S
authors.lastname: Gaikwad
authors.forename: Kyle
authors.initials: K
authors.lastname: Robinson
authors.forename: Erik
authors.initials: E
authors.lastname: Baatrup
authors.forename: Keith
authors.initials: K
authors.lastname: Tierney
authors.forename: Angela
authors.initials: A
authors.lastname: Shamchuk
authors.forename: William
authors.initials: W
authors.lastname: Norton
authors.forename: Noam
authors.initials: N
authors.lastname: Miller
authors.forename: Teresa
authors.initials: T
authors.lastname: Nicolson
authors.forename: Oliver
authors.initials: O
authors.lastname: Braubach
authors.forename: Charles P
authors.initials: CP
authors.lastname: Gilman
authors.forename: Julian
authors.initials: J
authors.lastname: Pittman
authors.forename: Denis B
authors.initials: DB
authors.lastname: Rosemberg
authors.forename: Robert
authors.initials: R
authors.lastname: Gerlai
authors.forename: David
authors.initials: D
authors.lastname: Echevarria
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Lamb
authors.forename: Stephan C F
authors.initials: SC
authors.lastname: Neuhauss
authors.forename: Wei
authors.initials: W
authors.lastname: Weng
authors.forename: Laure
authors.initials: L
authors.lastname: Bally-Cuif
authors.forename: Henning
authors.initials: H
authors.lastname: Schneider
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D005260:Female; D007814:Larva / Q000254:growth & development / Q000502:physiology; D008297:Male; D009424:Nervous System Physiological Phenomena; D012727:Sex Characteristics; D009626:Terminology as Topic; D015027:Zebrafish / Q000254:growth & development / Q000502:physiology*