title: Renal parenchyma developmental plasticity in mice infected with Schistosoma mansoni, whose mothers were malnourished during lactation.
abstract: Effects of maternal malnutrition during lactation on the kidneys in mice infected with Schistosoma mansoni. Kidneys from programmed infected mice and their respective controls fed a normal diet (23% protein), a protein-restricted group (PR) (8% protein) and a caloric-restricted group (CR) (according to the PR group intake) evaluated by biometry, morphometry and histopathology. Both PR and CR groups showed a reduction in the number of glomeruli when compared with the control group (CR: -29% vs C; PR: -41% vs C; p<0.05) as well as infected mice (ICR: -32% vs IC; IPR: -47% vs IC; p<0.05). Among infected mice, ICR group showed higher kidney weights (+18% vs IC and +12% vs IPR; p<0.01). The ICR and IPR groups showed largest perimeter and area when compared to the corresponding uninfected group (ICR vs CR: +26%; IPR vs PR: +21%, p<0.05) and area (ICR vs CR: +95%; IPR vs PR: +50%, p<0.05). The ICR group showed an increase of within Bowman (CR vs ICR: +56%, p<0.05), whereas Bowman's space was reduced (PR vs IPR, -61%; p<0.05). Conclude that malnutrition during lactation programmed the metabolic state of the host, resulting in the evolution of the histology of the renal parenchyma.
authors.affiliation: Laboratory of Helminthology Romero Lascasas Porto, Department of Microbiology, Immunology and Parasitology, Faculty of Medical Sciences, Immunology and Parasitology, School of Medical Sciences, Biomedical Center, Rua Prof. Manoel de Abreu 444/5° Floor, Vila Isabel, 20511-070 Rio de Janeiro, RJ, Brazil.
authors.forename: Christiane Leal
authors.initials: CL
authors.lastname: Corrêa
authors.forename: Júlio Cesar Antônio
authors.initials: JC
authors.lastname: Moreira
authors.forename: Augusto César Miranda
authors.initials: AC
authors.lastname: Vilela
authors.forename: Elaine
authors.initials: E
authors.lastname: de Oliveira
authors.forename: Egberto G
authors.initials: EG
authors.lastname: Moura
authors.forename: Patrícia Cristina
authors.initials: PC
authors.lastname: Lisboa
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Machado-Silva
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D031204:Caloric Restriction; D018753:Diet, Protein-Restricted; D004195:Disease Models, Animal; D005260:Female; D007668:Kidney / Q000254:growth & development / Q000473:pathology*; D007774:Lactation / Q000502:physiology*; D044342:Malnutrition / Q000150:complications*; D039382:Maternal Nutritional Physiological Phenomena / Q000502:physiology*; D051379:Mice; D012555:Schistosomiasis mansoni / Q000473:pathology*