title: A Pt(II)-Dip complex stabilizes parallel c-myc G-quadruplex.
abstract: A new G-quadruplex (GQ) stabilizer, [Pt(Dip)2](PF6)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ.
authors.affiliation: Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore.
authors.forename: Jintao
authors.initials: J
authors.lastname: Wang
authors.forename: Kaihui
authors.initials: K
authors.lastname: Lu
authors.forename: Shuguang
authors.initials: S
authors.lastname: Xuan
authors.forename: Zaozhen
authors.initials: Z
authors.lastname: Toh
authors.forename: Dawei
authors.initials: D
authors.lastname: Zhang
authors.forename: Fangwei
authors.initials: F
authors.lastname: Shao
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D054856:G-Quadruplexes; D006801:Humans; D010618:Phenanthrolines / Q000737:chemistry* / Q000494:pharmacology; D010984:Platinum / Q000737:chemistry* / Q000494:pharmacology; D016271:Proto-Oncogene Proteins c-myc
chemical_list: D010618:Phenanthrolines; D016271:Proto-Oncogene Proteins c-myc; D010984:Platinum