title: A study on the polymorphisms of the renin-angiotensin system pathway genes for their effect on blood pressure levels in males from Algeria.
abstract: BACKGROUND
  Several studies have assessed the relationship between blood pressure (BP) and polymorphisms within the genes encoding angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R) and angiotensin-converting enzyme (ACE). However, considering the relatively large discrepancy in frequency and impact of these variants between ethnic groups and populations, still unavailable data from Algerian population are needed.
  
  
  OBJECTIVE
  Our purpose is to evaluate the association between the AGT M235T, AT1R +1166A/C and ACE I/D polymorphisms and variations in systolic (SBP), diastolic (DBP) and pulse pressure (PP) values.
  
  
  METHODS
  The associations with BP were assessed in a representative sample of 115 male subjects free of coronary heart disease (CHD). The AGT M235T, AT1R +1166A/C and ACE I/D polymorphisms were determined by PCR-ASO and PCR-RFLP analysis, respectively.
  
  
  RESULTS
  We showed no associations between the AGT M235T, AT1R +1166A/C nor the ACE I/D polymorphisms with variations in BP values. However, concerning the ACE I/D polymorphism, subjects carrying the ACE I allele tended to have higher SBP (+4.1 mmHg) and PP values (+3.2 mmHg) than DD subjects (adjusted p = 0.087 and p = 0.102, respectively).
  
  
  CONCLUSIONS
  The ACE I/D polymorphism needs further investigation in a larger Algerian study, especially concerning its putative impact on SBP and PP.
authors.affiliation: 1Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohammed Boudiaf, Algeria.
authors.forename: Djabaria Naïma
authors.initials: DN
authors.lastname: Meroufel
authors.forename: Sounnia
authors.initials: S
authors.lastname: Médiène-Benchekor
authors.forename: Julie
authors.initials: J
authors.lastname: Dumont
authors.forename: Soraya
authors.initials: S
authors.lastname: Benhamamouch
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Thierry
authors.initials: T
authors.lastname: Brousseau
mesh_terms: D000328:Adult; D000462:Algeria; D000808:Angiotensinogen / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology*; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D012084:Renin-Angiotensin System / Q000235:genetics*
chemical_list: D044140:Receptor, Angiotensin, Type 1; D000808:Angiotensinogen; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Algerian population; Angiotensin II type 1 receptor; angiotensin-converting enzyme; angiotensinogen; genetic epidemiology; polymorphisms