title: Function of the p38MAPK-HSP27 pathway in rat lung injury induced by acute ischemic kidney injury.
abstract: This study aims to observe the changes and the function of p38MAPK-HSP27 signaling pathways in acute lung injury (ALI) induced by acute ischemic kidney injury in rats. Wistar rats were randomly divided into Group A (control group), Group B (acute kidney injury group), and Group C (acute kidney injury +SB203580). The concentration of protein in BALF, neutrophil counts, PI, W/D; the concentration of TNF- α , IL-6, and IL-1 β in plasma and BALF; and the concentrations of MDA and NO in the lung tissue started to increase 2 h after the experiment in Group B, which showed a significant difference compared with those in Groups A and C. The expressions of p-p38MAPK and p-HSP27 in the lung tissue began to increase 2 h after the experiment in Group B, which was different from those in Groups A and C. A significant increase was observed in the F-actin expression in Group B than that in Group A. In Group B, the correlation of cytokine TNF- α , IL-6, and p-p38MAPK in BALF was positive. Acute kidney injury (AKI) induced by bilateral renal arteriovenous clamp closure could activate p38MAPK-HSP27 signaling pathways and induce lung injury, which blocks the p38MAPK-HSP27 signal pathway to reduce the risk of lung injury.
authors.affiliation: Department of Emergency Medicine, The First Hospital of China Medical University, No 155 Nanjing North Street, Heping District, Shenyang City, Liaoning Province 110001, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Ma
authors.forename: Xiao Wei
authors.initials: XW
authors.lastname: Liu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Liu
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism* / Q000473:pathology; D055371:Acute Lung Injury / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001772:Blood Cell Count; D005786:Gene Expression Regulation / Q000187:drug effects; D055551:HSP27 Heat-Shock Proteins / Q000378:metabolism*; D007093:Imidazoles / Q000008:administration & dosage; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008168:Lung / Q000378:metabolism; D008297:Male; D048308:Mitogen-Activated Protein Kinase 14 / Q000378:metabolism*; D011725:Pyridines / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D055551:HSP27 Heat-Shock Proteins; D007093:Imidazoles; D053583:Interleukin-1beta; D015850:Interleukin-6; D011725:Pyridines; D014409:Tumor Necrosis Factor-alpha; D048308:Mitogen-Activated Protein Kinase 14; C093642:SB 203580