title: No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment.
abstract: B-cell precursors (BCP) regeneration in bone marrow (BM) after induction chemotherapy is prognostic for good treatment response in adult acute myeloid leukaemia (AML). We detected BCP regeneration in 81% of 59 paediatric AML patients at first complete remission; this compared to 46% in an adult study. BCP regeneration did not correlate with outcome or minimal residual disease levels. In 36 healthy BM controls, BCP levels were significantly higher in children as compared to adults. Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML, possibly due to the relatively high base-line levels of BCP in children.
authors.affiliation: Department of Immunology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
authors.forename: Anne E
authors.initials: AE
authors.lastname: Bras
authors.forename: Marry M
authors.initials: MM
authors.lastname: van den Heuvel-Eibrink
authors.forename: Alita J
authors.initials: AJ
authors.lastname: van der Sluijs-Gelling
authors.forename: Eva A
authors.initials: EA
authors.lastname: Coenen
authors.forename: Henk
authors.initials: H
authors.lastname: Wind
authors.forename: C Michel
authors.initials: CM
authors.lastname: Zwaan
authors.forename: Jeroen G
authors.initials: JG
authors.lastname: te Marvelde
authors.forename: Mirjam
authors.initials: M
authors.lastname: van der Burg
authors.forename: Brenda
authors.initials: B
authors.lastname: Gibson
authors.forename: Anita W
authors.initials: AW
authors.lastname: Rijneveld
authors.forename: Valérie
authors.initials: V
authors.lastname: de Haas
authors.forename: Jacques J M
authors.initials: JJ
authors.lastname: van Dongen
authors.forename: Vincent H J
authors.initials: VH
authors.lastname: van der Velden
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D006801:Humans; D016130:Immunophenotyping; D060828:Induction Chemotherapy; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D008875:Middle Aged; D010641:Phenotype; D054448:Precursor Cells, B-Lymphoid / Q000378:metabolism*; D011379:Prognosis; D012008:Recurrence; D016896:Treatment Outcome; D055815:Young Adult