title: Anticonvulsant activity of 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose isolated from leaves of Mangifera indica.
abstract: The present study was aimed to evaluate the anticonvulsant activity of 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (PGG) isolated from methanolic leaf extracts of Mangifera indica in mice. Anticonvulsant activity of PGG was evaluated against pentylenetetrazole (PTZ)-induced and maximal electroshock (MES)-induced convulsions in mice. Additionally, locomotor activity and GABA levels in the brain were estimated to explore the possible CNS-depressant activity and mechanism behind the anticonvulsant activity, respectively. In these studies, PGG (2.5, 5, and 10 mg/kg, intraperitoneal (i.p.)) showed significant and dose-dependent inhibition of PTZ and MES-induced convulsions. Furthermore, PGG administration showed significant decrease in the locomotor activity as an indication of its CNS-depressant property; also, PGG has significantly increased the GABA levels in the cerebellum and whole brain other than the cerebellum. In conclusion, PGG isolated from M. indica showed potent anticonvulsant activity, and possible mechanism may be due to enhanced GABA levels in the brain.
authors.affiliation: Department of Pharmacology, PES College of Pharmacy, Bangalore 560050, India. glv_000@yahoo.com
authors.forename: G L
authors.initials: GL
authors.lastname: Viswanatha
authors.forename: C G
authors.initials: CG
authors.lastname: Mohan
authors.forename: H
authors.initials: H
authors.lastname: Shylaja
authors.forename: H C
authors.initials: HC
authors.lastname: Yuvaraj
authors.forename: V
authors.initials: V
authors.lastname: Sunil
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism; D004597:Electroshock; D047348:Hydrolyzable Tannins / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D031022:Mangifera; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole; D008517:Phytotherapy; D018515:Plant Leaves; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D047348:Hydrolyzable Tannins; C435084:pentagalloylglucose; D005680:gamma-Aminobutyric Acid; D010433:Pentylenetetrazole