title: A Novel Cobalt(II) Coordination Complex Constructed from H2Pyri and 4,4'-Bipy: Synthesis, Characterization and Bioactivity.
abstract: The new complex of {[Co(4,4'-Bipy)(H2O)4]·(Pyri) · 3H2O}n (4,4'-Bipy = 4,4'-bipyridyl, H2Pyri = 3,5- Pyridinedicarboxylic acid) was synthesized and characterized by IR, element analysis and X-ray single-crystal diffraction. The binding of the complex with extracted HeLa cells DNA was investigated by UV and fluorescence spectrum. Gel electrophoresis assay demonstrated the ability of the complex cleaving the extracted HC-DNA. The complex exhibited a higher cytotoxicity against tumor cells in vitro. Furthermore, the apoptotic tests indicated the complex had an apoptotic effect on HeLa cells.
authors.affiliation: Department of Coordination Chemistry, Shenyang University of Chemical Technology, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang 110142, China. enjungao@163.com.
authors.forename: Enjun
authors.initials: E
authors.lastname: Gao
authors.forename: Fuchen
authors.initials: F
authors.lastname: Zhao
authors.forename: Mingchang
authors.initials: M
authors.lastname: Zhu
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry* / Q000494:pharmacology*; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray / Q000379:methods; D004247:DNA / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D011725:Pyridines; D003035:Cobalt; D004247:DNA; C034306:4,4'-bipyridyl