title: IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic.
abstract: IL-22 is a good candidate to play a critical role in regulating gut microbiota because it is an important inducer of antimicrobial peptides and mucins in the gut. However, whether IL-22 participates in immune homeostasis by way of modulating gut microbiota remains to be elucidated. In this study, we find, through 16S rRNA gene-pyrosequencing analysis, that healthy IL-22-deficient mice had altered colonic microbiota, notably with decreased abundance of some genera, including Lactobacillus, and increased levels of others. Mice harboring this altered microbiota exhibited more severe disease during experimentally induced colitis. Interestingly, this altered gut microbiota can be transmitted to cohoused wild-type animals along with the increased susceptibility to this colitis, indicating an important role for IL-22 in shaping the homeostatic balance between immunity and colonic microbiota for host health.
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Zenewicz
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Yin
authors.forename: Guoyang
authors.initials: G
authors.lastname: Wang
authors.forename: Eran
authors.initials: E
authors.lastname: Elinav
authors.forename: Liming
authors.initials: L
authors.lastname: Hao
authors.forename: Liping
authors.initials: L
authors.lastname: Zhao
authors.forename: Richard A
authors.initials: RA
authors.lastname: Flavell
mesh_terms: D000818:Animals; D001483:Base Sequence; D003092:Colitis / Q000276:immunology* / Q000382:microbiology*; D003106:Colon / Q000382:microbiology*; D003108:Colonic Diseases / Q000382:microbiology*; D016998:Helicobacter; D007378:Interleukins / Q000172:deficiency* / Q000235:genetics; D007778:Lactobacillus; D054892:Metagenome; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012336:RNA, Ribosomal, 16S; D017423:Sequence Analysis, RNA; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D012336:RNA, Ribosomal, 16S; D000097043:Interleukin-22