title: Successful treatment of acquired hemophilia a with rituximab and steroids in a 5-year-old girl.
abstract: Acquired hemophilia A is a very rare, serious bleeding disorder. We describe a 5-year-old female who developed an acquired factor VIII inhibitor, and while under treatment with steroids, had an intestinal perforation with peritonitis and septic shock, making her a poor candidate for further immunosuppression. She was treated with rituximab with rapid, complete eradication of the inhibitor. She represents the first published case of a pediatric patient with acquired hemophilia A successfully treated with rituximab.
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology and Oncology, Louisiana State University Health Sciences Center at New Orleans, New Orleans, LA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Fletcher
authors.forename: Ofelia
authors.initials: O
authors.lastname: Crombet
authors.forename: Jaime
authors.initials: J
authors.lastname: Morales-Arias
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D002675:Child, Preschool; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D000069283:Rituximab
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D000069283:Rituximab; D011241:Prednisone