title: Clauraila E from the roots of Clausena harmandiana and antifungal activity against Pythium insidiosum.
abstract: A new carbazole alkaloid named clauraila E (1) together with 8 known compounds were isolated from the methanol extract of the roots of Clausena harmandiana. All compounds were evaluated for antifungal activity against Pythium insidiosum using disc diffusion assay. Pythium insidiosum is a fungus-like microorganism, for which antifungals available now are not effective. It was found that compounds 3, 6, 7 and 9 could inhibit the mycelia growth of P. insidiosum. The results show convincingly that they may be lead to compounds for the development of probiotic or novel antifungal drugs.
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Natural Products Research Unit, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
authors.forename: Uraiwan
authors.initials: U
authors.lastname: Sriphana
authors.forename: Yordhathai
authors.initials: Y
authors.lastname: Thongsri
authors.forename: Chularut
authors.initials: C
authors.lastname: Prariyachatigul
authors.forename: Chaveng
authors.initials: C
authors.lastname: Pakawatchai
authors.forename: Chavi
authors.initials: C
authors.lastname: Yenjai
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D054700:Clausena / Q000737:chemistry*; D052978:Disk Diffusion Antimicrobial Tests; D055808:Drug Discovery; D020834:Ethnopharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D025282:Mycelium / Q000187:drug effects / Q000254:growth & development; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry*; D058968:Pythiosis / Q000188:drug therapy; D011775:Pythium / Q000187:drug effects* / Q000254:growth & development; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D013785:Thailand; D044366:Transition Temperature
chemical_list: D000470:Alkaloids; D000935:Antifungal Agents; D001578:Benzopyrans; D002227:Carbazoles; D010936:Plant Extracts; C588080:clauraila E