title: Potential for therapeutic manipulation of the UPR in disease.
abstract: Increased endoplasmic reticulum (ER) stress and the activated unfolded protein response (UPR) signaling associated with it play key roles in physiological processes as well as under pathological conditions. The UPR normally protects cells and re-establishes cellular homeostasis, but prolonged UPR activation can lead to the development of various pathologies. These features make the UPR signaling pathway an attractive target for the treatment of diseases whose pathogenesis is characterized by chronic activation of this pathway. Here, we focus on the molecular signaling pathways of the UPR and suggest possible ways to target this response for therapeutic purposes.
authors.affiliation: Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Park
authors.forename: Umut
authors.initials: U
authors.lastname: Ozcan
mesh_terms: D000818:Animals; D004358:Drug Therapy; D004721:Endoplasmic Reticulum / Q000502:physiology; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D056811:Unfolded Protein Response / Q000187:drug effects / Q000502:physiology
chemical_list: D018832:Molecular Chaperones