title: New dimeric and trimeric coumarin glucosides from Daphne retusa Hemsl.
abstract: New dimeric and a trimeric coumarin glucosides namely Daphneretusin A (1) Daphneretusin B (2) along with three known oligomers (3-5) were obtained as a result of bioassay guided fractionation of Daphne retusa Hemsl. Fractions (n-hexane, CHCl3, AcOEt, CH3OH and water) exhibited potent radical scavenging activity in relevant non-physiological bioassays. The structures of isolated compounds were elucidated by UV, IR, EIMS, FAB-MS, 1D, and 2D NMR spectroscopic analysis.
authors.affiliation: Department of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
authors.forename: Farrukh
authors.initials: F
authors.lastname: Mansoor
authors.affiliation: Department of Chemistry, University of Karachi, Karachi, 75270, Pakistan. Electronic address: itrat_anis@yahoo.com.
authors.forename: Itrat
authors.initials: I
authors.lastname: Anis
authors.affiliation: International Center for Chemical and Biological Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
authors.forename: Sajjad
authors.initials: S
authors.lastname: Ali
authors.affiliation: International Center for Chemical and Biological Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.affiliation: International Center for Chemical and Biological Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
authors.forename: Muhammad Raza
authors.initials: MR
authors.lastname: Shah
mesh_terms: D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032364:Daphne / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C000594160:6-(glucopyranosyl)oxy-7-((7-hydroxy-2-oxo-2H-1-benzopyran-8-yl)oxy)-3-((2-oxo-2H-1-benzopyran-7-yl)oxy)-2H-1-benzopyran-2-one; C000594159:6-(glucopyranosyl)oxy-7-hydroxy-3-((2-oxo-2H-1-benzopyran-7-yl)oxy)-2H-1-benzopyran-2-one; D003374:Coumarins; D016166:Free Radical Scavengers; D005960:Glucosides; D010936:Plant Extracts
keywords: Coumarin; Daphne retusa; Glucoside; Radical scavenging activity; Thymelaeaceae