title: APC polymorphisms and the risk of colorectal neoplasia: a HuGE review and meta-analysis.
abstract: Adenomatous polyposis coli gene (APC) polymorphisms may influence the risk for colorectal neoplasia. However, results thus far have been inconclusive. We performed a systematic literature search of the Medline, Embase, Cochrane Collaboration, and HuGE databases and reviewed the references of pertinent articles through May 2012. Odds ratios with 95% confidence intervals were used to estimate the association between 3 APC polymorphisms (D1822V, E1317Q, and I1307K) and colorectal neoplasia. In total, 40 studies from 1997 to 2010 were included in this meta-analysis, and individuals with the D1822V variant homozygote VV genotype had a slight decrease in the risk for colorectal neoplasia compared with the wild-type homozygote DD genotype (pooled odds ratio = 0.87, 95% confidence interval: 0.77, 0.99). There was a small association between the APC E1317Q polymorphism and a risk for colorectal neoplasia (variant vs. wild-type: pooled odds ratio = 1.41, 95% confidence interval: 1.14, 1.76), particularly for colorectal adenomas (variant vs. wild-type: odds ratio = 2.89, 95% confidence interval: 1.83, 4.56). Compared with those who carried the wild-type I1307K, Ashkenazi Jews who carried the I1307K variant were at a significantly increased risk for colorectal neoplasia, with a pooled odds ratio of 2.17 (95% confidence interval: 1.64, 2.86). Our study suggests that APC is a candidate gene for colorectal neoplasia susceptibility.
authors.affiliation: Department of Epidemiology, Public Health College, Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, Heilongjiang Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liang
authors.forename: Chunqing
authors.initials: C
authors.lastname: Lin
authors.forename: Fulan
authors.initials: F
authors.lastname: Hu
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yao
authors.forename: Yibaina
authors.initials: Y
authors.lastname: Wang
authors.forename: Yashuang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000236:Adenoma / Q000235:genetics*; D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D017491:Genes, APC; D006801:Humans; D020125:Mutation, Missense
chemical_list: C555337:APC protein, human; D025601:Adenomatous Polyposis Coli Protein
keywords: APC gene; colorectal cancer; epidemiology; genetics; genome, human; meta-analysis; polymorphism