title: Description of two new HLA-C alleles: C*08:63 and C*14:44.
abstract: Here, we present two new HLA allelic variants at C locus: HLA-C*08:63 and HLA-C*14:44 detected by sequence-based typing. In both cases, a single-nucleotide mutation in exon 3 is responsible for a change in aminoacid translation. The extremely high polymorphism of human leucocyte antigen (HLA) system in human genome is responsible for the capability to recognize different antigens, including non-self-MHC (Major Histocompatibility Complex) molecules. This very high polymorphism and the improving accuracy of genomic HLA typing methods lead to an exponential increasing of known HLA alleles. Here, we describe the characterization of two new HLA-C alleles identified by sequence-based typing (SBT): HLA-C*08:63 and HLA-C*14:44.
authors.affiliation: Dipartimento di Medicina Rigenerativa, Immunologia dei Trapianti di Organi e Tessuti, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italia.
authors.forename: M
authors.initials: M
authors.lastname: Mantovani
authors.forename: E
authors.initials: E
authors.lastname: Longhi
authors.forename: S
authors.initials: S
authors.lastname: Frison
authors.forename: R
authors.initials: R
authors.lastname: Lazzari
authors.forename: A
authors.initials: A
authors.lastname: Espadas De Arias
authors.forename: G
authors.initials: G
authors.lastname: Piccolo
authors.forename: F
authors.initials: F
authors.lastname: Poli
mesh_terms: D000483:Alleles; D001483:Base Sequence; D015236:HLA-C Antigens / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D015236:HLA-C Antigens