title: [Diagnostic and predictive analyses of cytological specimens of non-small cell lung cancer: strategies and challenges].
abstract: Personalised medicine is becoming the standard care for advanced non-small cell lung cancer. Tumour-specific therapies based on biomarker analyses, e. g., EGFR mutations or translocations of the ALK gene locus, result in a superior patient outcome compared to unselected therapy approaches. However, predictive molecular analyses can be challenging and require significant experience with cell- and tissue-based diagnostic methods. The major challenge relates to the sometimes low amount of available tumour material for both diagnostic and predictive analyses. As yet, there are no standardised or evidence-based recommendations concerning biopsies, specimen processing, and analyses. Respective guidelines require combined interdisciplinary actions to consider both clinical and pathological aspects. In order to establish a basis for high quality procedures, different approaches, methods, and protocols were interdisciplinary discussed with an emphasis on cytological specimens. Detailed evaluation of the parameters and consented recommendations might contribute to optimised strategies in the interdisciplinary, more and more complex care of non-small cell lung cancer patients.
authors.affiliation: Abteilung für Pneumologie und Intensivmedizin, Thoraxklinik am Universitätsklinikum Heidelberg, Germany.
authors.forename: F J F
authors.initials: FJ
authors.lastname: Herth
authors.forename: L
authors.initials: L
authors.lastname: Bubendorf
authors.forename: S
authors.initials: S
authors.lastname: Gütz
authors.forename: A
authors.initials: A
authors.lastname: Morresi-Hauf
authors.forename: M
authors.initials: M
authors.lastname: Hummel
authors.forename: K
authors.initials: K
authors.lastname: Junker
authors.forename: U
authors.initials: U
authors.lastname: Lehmann
authors.forename: I
authors.initials: I
authors.lastname: Petersen
authors.forename: P A
authors.initials: PA
authors.lastname: Schnabel
authors.forename: A
authors.initials: A
authors.lastname: Warth
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D057285:Precision Medicine / Q000379:methods*
chemical_list: D005819:Genetic Markers