title: Psychological well-being and regional brain amyloid and tau in mild cognitive impairment.
abstract: OBJECTIVE
  To determine whether psychological well-being in people with mild cognitive impairment (MCI), a risk state for Alzheimer disease (AD), is associated with in vivo measures of brain pathology.
  
  
  METHODS
  Cross-sectional clinical assessments and positron emission tomography (PET) scans after intravenous injections of 2-(1-{6-[(2-[F18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP), a molecule that binds to plaques and tangles, were performed on middle-aged and older adults at a university research institute. Volunteers were aged 40-85 years with MCI (N = 35) or normal cognition (N = 29) without depression or anxiety. Statistical analyses included general linear models, using regional FDDNP-PET binding values as dependent variables and the Vigor-Activity subscale of the Profile of Mood States (POMS) as the independent variable, covarying for age. The POMS is a self-rated inventory of 65 adjectives that describe positive and negative feelings.
  
  
  RESULTS
  Scores on the POMS Vigor-Activity subscale were inversely associated with degree of FDDNP binding in the posterior cingulate cortex (r = -0.35, p = 0.04) in the MCI group but not in the control group.
  
  
  CONCLUSIONS
  Psychological well-being, as indicated by self-reports of greater vigor and activity, is associated with lower FDDNP-PET binding in the posterior cingulate cortex, a region involved in emotional regulation, in individuals with MCI but not in those with normal cognition. These findings are consistent with previous work indicating that deposition of brain amyloid plaques and tau tangles may result in noncognitive and cognitive symptoms in persons at risk for AD.
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA. Electronic address: stephenchen@mednet.ucla.edu.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Chen
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA.
authors.forename: Prabha
authors.initials: P
authors.lastname: Siddarth
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA.
authors.forename: Nathan Y
authors.initials: NY
authors.lastname: Saito
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA.
authors.forename: Flori
authors.initials: F
authors.lastname: Rueda
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA.
authors.forename: Taylor
authors.initials: T
authors.lastname: Haight
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA; UCLA Longevity Center, University of California, Los Angeles, CA.
authors.forename: Linda M
authors.initials: LM
authors.lastname: Ercoli
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA; UCLA Longevity Center, University of California, Los Angeles, CA.
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Miller
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA.
authors.forename: Helen
authors.initials: H
authors.lastname: Lavretsky
authors.affiliation: Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA.
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Barrio
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA.
authors.forename: Susan Y
authors.initials: SY
authors.lastname: Bookheimer
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA; Alzheimer's Disease Research Center, University of California, Los Angeles, CA; UCLA Longevity Center, University of California, Los Angeles, CA.
authors.forename: Gary W
authors.initials: GW
authors.lastname: Small
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA; UCLA Longevity Center, University of California, Los Angeles, CA.
authors.forename: David A
authors.initials: DA
authors.lastname: Merrill
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides; D001921:Brain / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000000981:diagnostic imaging*; D009570:Nitriles; D010549:Personal Satisfaction; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D016875:tau Proteins
chemical_list: C444520:2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphthyl)ethylidene)malononitrile; D016229:Amyloid beta-Peptides; D009570:Nitriles; D019275:Radiopharmaceuticals; D016875:tau Proteins
keywords: Aging; FDDNP; POMS; positron emission tomography; well-being