title: Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis.
abstract: BACKGROUND
  Literature on the relationship between atopic dermatitis (AD) and cutaneous delayed-type hypersensitivity is inconclusive.
  
  
  OBJECTIVE
  We sought to compare the rates of positive patch test reactions to allergens on the North American Contact Dermatitis Group (NACDG) standard tray among patients with and without AD, and, to assess whether atopic patients in our database were more likely to patch test positive to certain classes of allergens.
  
  
  METHODS
  A total of 2305 patients underwent patch testing to the NACDG standard screening series. The incidence of positive patch test reactions among patients with AD (n = 297) and without AD (n = 2008) was assessed. Statistical analysis was done using a χ(2) test with Yates continuity correction.
  
  
  RESULTS
  Compared with nonatopic patients, those with AD were statistically more likely to have positive patch tests. AD was associated with contact hypersensitivity to nickel, cobalt, and chromium, but was not associated with contact sensitization to fragrances.
  
  
  CONCLUSIONS
  Only patients suspected of having allergic contact dermatitis were tested. Our population was geographically limited to metropolitan Kansas City (including Kansas City, MO, Kansas City, KS, and the adjoining suburbs).
  
  
  CONCLUSIONS
  Compared with nonatopics, patients with AD are significantly more likely to have at least 1 positive patch test reaction and to develop contact hypersensitivity to metal allergens.
authors.affiliation: Columbia University College of Physicians and Surgeons, New York, New York, USA.
authors.forename: Dana
authors.initials: D
authors.lastname: Malajian
authors.forename: Donald V
authors.initials: DV
authors.lastname: Belsito
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology*; D002857:Chromium / Q000276:immunology; D003035:Cobalt / Q000276:immunology; D015331:Cohort Studies; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D003876:Dermatitis, Atopic / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D005260:Female; D000091344:Filaggrin Proteins; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000276:immunology; D010328:Patch Tests; D010476:Perfume; D015995:Prevalence; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D000485:Allergens; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D010476:Perfume; D002857:Chromium; D003035:Cobalt; D009532:Nickel
keywords: AD; CDTH; FLG; NACDG; North American Contact Dermatitis Group; T helper cell; TLR; Th; Toll-like receptor; allergy; atopic dermatitis; atopic eczema; chromium; cobalt; contact dermatitis; cutaneous delayed-type hypersensitivity; filaggrin; hypersensitivity; nickel; patch testing