title: Polysulfones of new structural types as perspective antioxidant agents.
abstract: A series of polysulfones of new structural types on the basis of azanorbornenes, 2,2-diallyl-1,1,3,3-tetraethylguanidiniumchloride and tris(diethylamino)diallylaminophosphonium salts were obtained by free radical polymerization reaction. Their antioxidant properties in lipid peroxidation induced by iron/ascorbate and in erythrocyte hemolysis by H2O2 were evaluated. The polysulfone of 2,2-diallyl-1,1,3,3-tetraethylguanidinium chloride showed protection of erythrocytes against hydrogen peroxide and thermal shock, protected epithelial cells against UV irradiation, was not toxic for erythrocytes, epithelial cells SPEV and 3T3 fibroblasts. The polysulfone of N-benzyl-2-azanorbornene-5 inhibited lipid peroxidation in liver homogenate, did not exhibit cytotoxicity in SPEV and 3T3 cells, protected these against UV irradiation. Both compounds had low bioavailability and may be recommended for further investigations as excipients to be externally applied.
authors.affiliation: Institute of Technical Chemistry, Ural Branch of Russian Academy of Sciences, Korolev Str. 3, Perm 614013, Russia. mngorb@newmail.ru
authors.forename: Marina
authors.initials: M
authors.lastname: Gorbunova
authors.forename: Lada
authors.initials: L
authors.lastname: Anikina
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells / Q000187:drug effects / Q000528:radiation effects; D019791:Guanidine / Q000737:chemistry; D006461:Hemolysis / Q000187:drug effects; D006358:Hot Temperature; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007501:Iron / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008956:Models, Chemical; D015394:Molecular Structure; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013552:Swine; D014466:Ultraviolet Rays
chemical_list: D000975:Antioxidants; D016877:Oxidants; D011108:Polymers; D013450:Sulfones; D006861:Hydrogen Peroxide; D007501:Iron; D019791:Guanidine; D001205:Ascorbic Acid