title: Acute isoniazid intoxication: an uncommon cause of convulsion, coma and acidosis.
abstract: Despite the widespread use, suicidal ingestion of isoniazid is a rare condition in Turkey. We reported a case of acute isoniazid intoxication associated with alcohol intake presenting with convulsion, coma and metabolic acidosis. The patient was treated successfully with intravenous pyridoxine administration. Early recognation and appropriate treatment in the intensive care unit is very important to prevent mortality in patients with acute isoniazid toxicity.
authors.affiliation: Clinic of Anesthesiology and Reanimation, Haseki Training and Research Hospital, Istanbul, Turkey. drsinanuzman@yahoo.com
authors.forename: Sinan
authors.initials: S
authors.lastname: Uzman
authors.forename: Tümay
authors.initials: T
authors.lastname: Uludağ Yanaral
authors.forename: Mehmet
authors.initials: M
authors.lastname: Toptaş
authors.forename: Alparslan
authors.initials: A
authors.lastname: Koç
authors.forename: Aytül
authors.initials: A
authors.lastname: Taş
authors.forename: Gülşen
authors.initials: G
authors.lastname: Bican
mesh_terms: D000138:Acidosis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003128:Coma / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007262:Infusions, Intravenous; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D011736:Pyridoxine / Q000008:administration & dosage / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D013406:Suicide, Attempted; D016896:Treatment Outcome; D014421:Turkey; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D011736:Pyridoxine; D007538:Isoniazid