title: Effect of Korean pear (Pyruspyrifolia cv. Shingo) juice on hangover severity following alcohol consumption.
abstract: Korean pear has been used as a traditional prophylactic agent for alcohol hangover. However, its mechanism was not investigated in human yet. Therefore, we performed a randomized single blind crossover trial with 14 healthy young men to examine effects of Korean pear juice on alcohol hangover. All subjects consumed 540 ml of spirits (alcohol conc. 20.1 v/v%) after 30 min from the intervention, i.e. placebo or Korean pear juice treatment. Blood and urine specimens were collected in time-courses (9 time-points for 15 h after alcohol consumption). The total and average of hangover severity were alleviated to 16% and 21% by Korean pear juice at 15 h after the alcohol consumption, respectively (ps<0.05). Particularly, 'trouble concentrating' was significantly improved by the pear juice treatment (p<0.05). Impaired memory, and sensitivity to light and sound were significantly improved by Korean pear juice among the subjects with ALDH2*1/*1 or ALDH2*1/*2 genotypes (ps<0.05) but not in the subjects with ALDH2*2/*2 genotype. In addition, the pear juice treatment lowered levels of blood alcohol (p<0.01). Therefore, Korean pear juice may alleviate alcohol-hangover and its detoxification of alcohol seems to be modified by the genetic variation of ALDH2.
authors.affiliation: Research Center for Cell Fate Control, College of Pharmacy, Sookmyoung Women's University, Seoul, Republic of Korea.
authors.forename: Ho-Sun
authors.initials: HS
authors.lastname: Lee
authors.forename: Toyohi
authors.initials: T
authors.lastname: Isse
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kawamoto
authors.forename: Hyun Wook
authors.initials: HW
authors.lastname: Baik
authors.forename: Jong Y
authors.initials: JY
authors.lastname: Park
authors.forename: Mihi
authors.initials: M
authors.lastname: Yang
mesh_terms: D000328:Adult; D000426:Alcohol Dehydrogenase / Q000235:genetics; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D001628:Beverages; D018592:Cross-Over Studies; D005638:Fruit; D005838:Genotype; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010919:Placebos; D011110:Polymorphism, Genetic; D016037:Single-Blind Method
chemical_list: D010919:Placebos; D008315:Malondialdehyde; D000426:Alcohol Dehydrogenase
keywords: ALDH2; AUC; Alcohol; Hangover; IRB; Korean pear; MDA; PCA; PK; Pharmacodynamics; Pharmacokinetic; Pharmacokinetics; RFLP; TBA; VHT; acetaldehyde dehydrogenase2; areas under the curve; institutional review board; malondialdehyde; perchloric acid; restriction fragment length polymorphism; thiobarbituric acid; vital sign and hematological tests