title: Germ cell tumor in an adolescent with extensive testicular microlithiasis: concerns regarding future management.
abstract: We report on a 14-year-old boy with bilateral testicular microlithiasis and a right-sided testicular tumor. Tumor markers alpha-fetoprotein (AFP) and β-human chorionic gonadrotropin (β-hCG) levels were elevated and orchiectomy revealed a mixed germ cell tumor consisting of embryonal carcinoma, yolk sac tumor, choriocarcinoma, and mature teratoma. The patient had no evidence of metastatic disease. Although there is a strong association between testicular microlithiasis and testicular tumor, the pediatric literature is varying in the recommended surveillance of these patients. The literature and management of pediatric patients with testicular microlithiasis is herein reviewed.
authors.affiliation: New Jersey Medical School, University of Medicine and Dentisty of New Jersey, Newark, NJ, USA. ginacambareri@gmail.com
authors.forename: Gina M
authors.initials: GM
authors.lastname: Cambareri
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Reiley
authors.forename: Terry W
authors.initials: TW
authors.lastname: Hensle
mesh_terms: D000293:Adolescent; D002137:Calculi / Q000150:complications*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D009919:Orchiectomy; D013733:Testicular Diseases / Q000150:complications*; D013736:Testicular Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins