title: Clinical characteristics and treatment of angiomatous meningiomas: a report of 27 cases.
abstract: Angiomatous meningioma (AM) is a rare histological variant of meningioma. Twenty seven patients (14 male and 13 female) with angiomatous meningioma were treated in our institution. Their clinical presentation, neuroimaging studies, treatment and follow-up were investigated. The age of patients ranged from 24 to 72 years with a mean of 51.8 years. The clinical presentation was non-specific and depended on the location of the tumor and was mainly due to the mass effect. On computed tomography (CT) scanning, AMs showed slightly hyperintensity. On magnetic resonance imaging (MRI), AMs demonstrated hypointensity on T1-weighted images (T1WI), hyperintensity on T2-weighted images (T2WI), slight hypointensity on diffusion-weighted images (DWI), enhancement on postcontrast T1WI, peritumoral edema, and rich signal voids of vessels in the tumor. On histology, all tumors exhibited abundant blood vessels with at least focal classic meningothelial differentiation. Thirteen, eight, and six cases were achieved Simpson grade I, II and III-IV resection respectively. Nineteen cases were followed for 8 to 125 months with a mean of 47.9 months. Four patients with residual tumor were treated with postoperative radiation therapy and all of them had stable disease. One patient with Simpson grade II resection was not treated with radiation therapy and developed recurrent tumor in 5 years. In conclusion, angiomatous meningiomas have relative high male to female ratio, more frequent peritumoral edema, and rich blood vessels. Gross total resection is still the treatment of choice. These patients with residual tumor after surgery can benefit from radiation therapy. Overall, the prognosis of AMs are as good as other benign meningiomas.
authors.affiliation: Department of Neurosurgery, Qilu Hospital of Shandong University, Brain Science Research Institute of Shandong University, Jinan, Shandong Province, PR China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Liu
authors.forename: Chuanwei
authors.initials: C
authors.lastname: Wang
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
authors.forename: Yunyan
authors.initials: Y
authors.lastname: Wang
authors.forename: Jian Yi
authors.initials: JY
authors.lastname: Li
authors.forename: Yuguang
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000098:blood supply / Q000473:pathology* / Q000628:therapy*; D008579:Meningioma / Q000098:blood supply / Q000473:pathology* / Q000628:therapy*; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D019635:Neurosurgical Procedures; D011379:Prognosis; D011878:Radiotherapy; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Angiomatous meningioma; computed tomography (CT); magnetic resonance imaging (MRI); radiation therapy; surgery