title: Cost-effectiveness of Multisystemic Therapy for adolescents with antisocial behaviour: study protocol of a randomized controlled trial.
abstract: BACKGROUND
  Multisystemic Therapy (MST) is an intensive, short, family- and community-based treatment for serious antisocial behaviour and delinquency in youth. It is an emerging intervention for serious juvenile delinquents. However, conclusive evidence on the balance between costs and effects is limited and in fact non-existent for the Netherlands. The aim of this protocol is to describe the design of a study to evaluate the cost-effectiveness of MST as compared to Care-As-Usual (CAU).
  
  
  METHODS
  The cost-effectiveness of MST will be assessed through a Randomised Controlled Trial. Primary outcomes aggressive and delinquent behaviour will be assessed with the parent-reported CBCL and adolescent-reported YSR. Health care utilisation, production loss, and quality of life are recorded using the self-report 'Trimbos and iMTA questionnaire on Costs associated with Psychiatric illness' (TiC-P), and with the MOS Short-Form General Health Survey (SF-20) and EuroQol -5D (EQ-5D), respectively. The study aims to enrol 100 clients in both conditions (MST and CAU). Data will be obtained before treatment (T1), immediately after treatment (T2; 5 months after T1) and at follow up (T3; 6 months after the end of the treatment) from a variety of sources, i.e. clients, parents/primary carers, professionals and police records.
  
  
  CONCLUSIONS
  Studying the cost-effectiveness of this treatment for youth antisocial behaviour is important in order to provide information to policy makers on whether the provision of this intervention represents good value for money. Introducing a cost-effective evidence based programme may result in valuable health gains for moderate costs.
  
  
  BACKGROUND
  NTR1390.
authors.affiliation: Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, PO Box 196, 9700 AD, the Netherlands. d.e.m.c.jansen@umcg.nl.
authors.forename: Danielle E M C
authors.initials: DE
authors.lastname: Jansen
authors.forename: Karin M
authors.initials: KM
authors.lastname: Vermeulen
authors.forename: Annemieke H
authors.initials: AH
authors.lastname: Schuurman-Luinge
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Knorth
authors.forename: Erik
authors.initials: E
authors.lastname: Buskens
authors.forename: Sijmen A
authors.initials: SA
authors.lastname: Reijneveld
mesh_terms: D000293:Adolescent; D000987:Antisocial Personality Disorder / Q000523:psychology / Q000628:therapy*; D001521:Behavior Therapy / Q000191:economics*; D002648:Child; D003362:Cost-Benefit Analysis; D005190:Family; D005260:Female; D006801:Humans; D007604:Juvenile Delinquency / Q000523:psychology; D008297:Male; D009426:Netherlands; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome