title: [SNP of rs17321515 homologous with Trib1 in Han population and its correlation with blood lipid].
abstract: OBJECTIVE
  To study on genotype distribution of rs17321515 which is homologous with Trib1 and its associativity with blood lipid parameters and diagnosis.
  
  
  METHODS
  Collecting 1 014 blood samples to measure its lipid levels, then detecting rs17321515 locus's SNP by MALDI-TOF mass spectrometry technology.
  
  
  RESULTS
  Three genotypes (A/A, A/G, G/G) proportions in the population were 13.8%, 50.2% and 36.0%, allele frequencies were A: G = 38.9% : 61.1%. In variance analysis, variation of TG of male was statistical significant (F = 4.46, P = 0.01), TG level of male who carried AG is lower than GG carries ( t = 0.29, P = 0.02). Logistic regression analysis showed that, hypertriglyceridemia prevalence of male who carried AA is lower than GG carries (OR = 0.45, P = 0.04). Low HDL-c acidosis prevalence of male who carried AG is lower than GG carries (OR = 0.62, P = 0.03). Hypercholesterolemia prevalence of female who carried AG is lower than GG carries (OR = 0.58, P = 0.01).
  
  
  CONCLUSIONS
  Allele frequencies of rs17321515 varies in different ethnic groups; The locus' polymorphism distribution is relevant with a certain lipid indicators and lipid diagnosis, but there exist gender differences on these relevance.
authors.affiliation: School of Health Management, Hangzhou Normal University, Hangzhou 310018, China. lanman.ok@163.com
authors.forename: Man
authors.initials: M
authors.lastname: Lan
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Wenwei
authors.initials: W
authors.lastname: Shi
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Liangwen
authors.initials: L
authors.lastname: Xu
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Tan
authors.forename: Jintao
authors.initials: J
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Meng
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000235:genetics; D017385:Sequence Homology; D055815:Young Adult
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D008055:Lipids; C493170:TRIB1 protein, human; D017346:Protein Serine-Threonine Kinases