title: Current status of liposomal porphyrinoid photosensitizers.
abstract: The complete eradication of various targets, such as infectious agents or cancer cells, while leaving healthy host cells untouched, is still a great challenge faced in the field of medicine. Photodynamic therapy (PDT) seems to be a promising approach for anticancer treatment, as well as to combat various dermatologic and ophthalmic diseases and microbial infections. The application of liposomes as delivery systems for porphyrinoids has helped overcome many drawbacks of conventional photosensitizers and facilitated the development of novel effective photosensitizers that can be encapsulated in liposomes. The development, preclinical studies and future directions for liposomal delivery of conventional and novel photosensitizers are reviewed.
authors.affiliation: Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland. p_skupin@wp.pl
authors.forename: Paulina
authors.initials: P
authors.lastname: Skupin-Mrugalska
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Piskorz
authors.forename: Tomasz
authors.initials: T
authors.lastname: Goslinski
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Mielcarek
authors.forename: Krystyna
authors.initials: K
authors.lastname: Konopka
authors.forename: Nejat
authors.initials: N
authors.lastname: Düzgüneş
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D006801:Humans; D008081:Liposomes; D010778:Photochemotherapy / Q000379:methods* / Q000639:trends; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry*; D011166:Porphyrins / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D017319:Photosensitizing Agents; D011166:Porphyrins