title: [Use of NSAIDs in rheumatoid arthritis should be limited].
abstract: In a Cochrane review the safety of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin in people receiving methotrexate (MTX) for rheumatoid arthritis was evaluated. A total of 17 publications were analyzed. Concurrent use anti-inflammatory doses of aspirin with MTX were associated with renal and hepatic side effects, whereas NSAIDs appeared to be safe. Nevertheless there are well-known gastrointestinal, cardiovascular and renal side effects from NSAIDs. In my opinion, use of NSAIDs in rheumatoid arthritis should be limited, as there are better and less risky alternatives.
authors.affiliation: Akutcentret, Sygehus Sønderjylland, Egelund 10, 6200 Aabenraa, Denmark. mli@dadlnet.dk
authors.forename: Mats
authors.initials: M
authors.lastname: Lindberg
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001241:Aspirin / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D012196:Review Literature as Topic
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018501:Antirheumatic Agents; D001241:Aspirin; D008727:Methotrexate