title: Learning from nature to improve the heat generation of iron-oxide nanoparticles for magnetic hyperthermia applications.
abstract: The performance of magnetic nanoparticles is intimately entwined with their structure, mean size and magnetic anisotropy. Besides, ensembles offer a unique way of engineering the magnetic response by modifying the strength of the dipolar interactions between particles. Here we report on an experimental and theoretical analysis of magnetic hyperthermia, a rapidly developing technique in medical research and oncology. Experimentally, we demonstrate that single-domain cubic iron oxide particles resembling bacterial magnetosomes have superior magnetic heating efficiency compared to spherical particles of similar sizes. Monte Carlo simulations at the atomic level corroborate the larger anisotropy of the cubic particles in comparison with the spherical ones, thus evidencing the beneficial role of surface anisotropy in the improved heating power. Moreover we establish a quantitative link between the particle assembling, the interactions and the heating properties. This knowledge opens new perspectives for improved hyperthermia, an alternative to conventional cancer therapies.
authors.affiliation: Departament d'Electrònica and IN2UB, Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain. cmartinezboubeta@ub.edu
authors.forename: Carlos
authors.initials: C
authors.lastname: Martinez-Boubeta
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Simeonidis
authors.forename: Antonios
authors.initials: A
authors.lastname: Makridis
authors.forename: Makis
authors.initials: M
authors.lastname: Angelakeris
authors.forename: Oscar
authors.initials: O
authors.lastname: Iglesias
authors.forename: Pablo
authors.initials: P
authors.lastname: Guardia
authors.forename: Andreu
authors.initials: A
authors.lastname: Cabot
authors.forename: Lluis
authors.initials: L
authors.lastname: Yedra
authors.forename: Sonia
authors.initials: S
authors.lastname: Estradé
authors.forename: Francesca
authors.initials: F
authors.lastname: Peiró
authors.forename: Zineb
authors.initials: Z
authors.lastname: Saghi
authors.forename: Paul A
authors.initials: PA
authors.lastname: Midgley
authors.forename: Iván
authors.initials: I
authors.lastname: Conde-Leborán
authors.forename: David
authors.initials: D
authors.lastname: Serantes
authors.forename: Daniel
authors.initials: D
authors.lastname: Baldomir
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry* / Q000528:radiation effects*; D006358:Hot Temperature; D006979:Hyperthermia, Induced / Q000379:methods*; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000528:radiation effects / Q000627:therapeutic use*; D055944:Magnetosomes / Q000737:chemistry* / Q000528:radiation effects*; D008422:Materials Testing; D011829:Radiation Dosage
chemical_list: D058185:Magnetite Nanoparticles