title: Perspective on fever: the basic science and conventional medicine.
abstract: This review describes how fever is generated as a regulated increase in body temperature. It results from an upward shift in the thermoregulatory set point, mediated by pyrogenic cytokines released from monocytes/macrophages in response to infection or trauma. Evidence will be presented that fever is part of an integrated host defense system, and that failure to generate a fever in response to infection is generally associated with a poorer prognosis.
authors.affiliation: College of Allied Health Sciences, Georgia Health Sciences University, Augusta, GA 30912, USA. jcannon@georgiahealth.edu
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Cannon
mesh_terms: D001831:Body Temperature / Q000276:immunology*; D001833:Body Temperature Regulation / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism*; D005334:Fever / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007239:Infections / Q000276:immunology* / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism; D014947:Wounds and Injuries / Q000276:immunology / Q000378:metabolism
chemical_list: D016207:Cytokines