title: The sequence and analysis of a Chinese pig genome.
abstract: BACKGROUND
  The pig is an economically important food source, amounting to approximately 40% of all meat consumed worldwide. Pigs also serve as an important model organism because of their similarity to humans at the anatomical, physiological and genetic level, making them very useful for studying a variety of human diseases. A pig strain of particular interest is the miniature pig, specifically the Wuzhishan pig (WZSP), as it has been extensively inbred. Its high level of homozygosity offers increased ease for selective breeding for specific traits and a more straightforward understanding of the genetic changes that underlie its biological characteristics. WZSP also serves as a promising means for applications in surgery, tissue engineering, and xenotransplantation. Here, we report the sequencing and analysis of an inbreeding WZSP genome.
  
  
  RESULTS
  Our results reveal some unique genomic features, including a relatively high level of homozygosity in the diploid genome, an unusual distribution of heterozygosity, an over-representation of tRNA-derived transposable elements, a small amount of porcine endogenous retrovirus, and a lack of type C retroviruses. In addition, we carried out systematic research on gene evolution, together with a detailed investigation of the counterparts of human drug target genes.
  
  
  CONCLUSIONS
  Our results provide the opportunity to more clearly define the genomic character of pig, which could enhance our ability to create more useful pig models.
authors.affiliation: BGI-Shenzhen, Bei Shan Road, Yantian, Shenzhen, 518083, China. Fst508@sina.com.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Fang
authors.forename: Yulian
authors.initials: Y
authors.lastname: Mou
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Huang
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Lijuan
authors.initials: L
authors.lastname: Han
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yue
authors.initials: Y
authors.lastname: Feng
authors.forename: Yuanxin
authors.initials: Y
authors.lastname: Chen
authors.forename: Xuanting
authors.initials: X
authors.lastname: Jiang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Sun
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Xiong
authors.forename: Lan
authors.initials: L
authors.lastname: Yang
authors.forename: Huan
authors.initials: H
authors.lastname: Liu
authors.forename: Dingding
authors.initials: D
authors.lastname: Fan
authors.forename: Likai
authors.initials: L
authors.lastname: Mao
authors.forename: Lijie
authors.initials: L
authors.lastname: Ren
authors.forename: Chuxin
authors.initials: C
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Kui
authors.initials: K
authors.lastname: Li
authors.forename: Guangbiao
authors.initials: G
authors.lastname: Wang
authors.forename: Shulin
authors.initials: S
authors.lastname: Yang
authors.forename: Liangxue
authors.initials: L
authors.lastname: Lai
authors.forename: Guojie
authors.initials: G
authors.lastname: Zhang
authors.forename: Yingrui
authors.initials: Y
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Lars
authors.initials: L
authors.lastname: Bolund
authors.forename: Huanming
authors.initials: H
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Shutang
authors.initials: S
authors.lastname: Feng
authors.forename: Songgang
authors.initials: S
authors.lastname: Li
authors.forename: Yutao
authors.initials: Y
authors.lastname: Du