title: Follicular cutaneous squamous cell carcinoma: an under-recognized neoplasm arising from hair appendage structures.
abstract: BACKGROUND
  Cutaneous squamous cell carcinoma (SCC) with no demonstrable point of epidermal origin is problematic as it raises consideration of metastatic SCC histologically. There are rare case reports and series of SCC arising from the wall of hair follicle structures. Such lesions have been termed follicular SCC (FSCC).
  
  
  OBJECTIVE
  To investigate the clinicopathological features of FSCC.
  
  
  METHODS
  We prospectively collected cases of follicular SCC over a 5-year period. Follicular SCC is defined as a cutaneous SCC deriving from a pre-existing hair follicle structure. Lesions were considered to represent 'hybrid' SCCs if an interfollicular epidermal origin was also demonstrated; SCCs with > 50% of the origin from interfollicular epidermis were excluded. Histological features and clinical information were evaluated.
  
  
  RESULTS
  We identified 61 cases of follicular SCC arising in 60 patients from a database of 5212 cutaneous SCCs encountered over the same time period by the same authors. There were 49 pure follicular SCCs and 12 hybrid lesions. The male to female ratio was 44 : 16; the mean age was 74 years (range 44-93). Follicular SCC represents 1·2% of all primary SCCs. Biopsies of such lesions, if the appendage structure of origin is not represented, are histologically indistinguishable from metastatic SCC.
  
  
  CONCLUSIONS
  Recognition of this under-reported form of SCC is essential if an inappropriate diagnosis of metastatic SCC, with potentially harmful and inappropriate therapy and investigation, is to be avoided.
authors.affiliation: University of Oklahoma and Regional Medical Laboratory, Tulsa, OK, USA. IShendrik@sjmc.org
authors.forename: I
authors.initials: I
authors.lastname: Shendrik
authors.forename: A N
authors.initials: AN
authors.lastname: Crowson
authors.forename: C M
authors.initials: CM
authors.lastname: Magro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003937:Diagnosis, Differential; D005121:Extremities; D005260:Female; D006201:Hair Diseases / Q000473:pathology; D018859:Hair Follicle / Q000473:pathology*; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012878:Skin Neoplasms / Q000473:pathology*; D013909:Thorax