title: Relationship between bone mineral density and moderate to severe chronic kidney disease among general population in Korea.
abstract: Recent studies in Western countries have reported a significant association between glomerular filtration rate (GFR) and bone mineral density (BMD) in the absence of dialysis among the general population. However, there have been few studies regarding renal function and BMD among Korean or Asian subjects with moderate to severe (stage 3 or 4) chronic kidney disease (MS-CKD). The aim of the present study was to investigate the association between MS-CKD and BMD in the general Korean population. BMD, serum creatinine and other measures were obtained from 3,190 subjects (1,428 males and 1,762 females; the fourth Korean National Health and Nutrition Examination Survey). GFR was estimated using the Cockcroft-Gault formula, with adjustment for body surface area. After adjustment for all variables, multiple regression analysis showed that BMD in the femur neck, total femur and lumbar spine were positively associated with eGFR in both males and females. Additional analysis showed that MS-CKD was also significantly associated with osteoporosis in both males and females (odds ratio [OR] 2.20, 95% confidence interval [CI] 1.15-4.20 in males; and OR 1.96, 95% CI 1.33-2.88 in females). Individuals with MS-CKD may be at higher risk of osteoporosis even among Asians.
authors.affiliation: Department of Occupational and Environmental Medicine, Center for Occupational and Environmental Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jun-Pyo
authors.initials: JP
authors.lastname: Myong
authors.forename: Hyoung-Ryoul
authors.initials: HR
authors.lastname: Kim
authors.forename: Jung-Wan
authors.initials: JW
authors.lastname: Koo
authors.forename: Chung Yill
authors.initials: CY
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density; D003404:Creatinine / Q000097:blood; D005260:Female; D005269:Femur / Q000503:physiopathology; D005272:Femur Neck / Q000503:physiopathology; D005919:Glomerular Filtration Rate; D006801:Humans; D008159:Lumbar Vertebrae / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D016017:Odds Ratio; D010024:Osteoporosis / Q000209:etiology; D012044:Regression Analysis; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000503:physiopathology*; D056910:Republic of Korea; D012720:Severity of Illness Index
chemical_list: D003404:Creatinine
keywords: Bone Density; Glomerular Filtration Rate; KNHANES; Osteoporosis; Renal Insufficiency