title: Effect of Biophytum sensitivum on streptozotocin and nicotinamide-induced diabetic rats.
abstract: OBJECTIVE
  To investigate the effect of aqueous solution of Biophytum sensitivum leaf extract (BSEt) on normal and streptozotocin (STZ)-nicotinamide-induced diabetic rats.
  
  
  METHODS
  Diabetes was induced in adult male Wistar rats by the administration of STZ-nicotinamide (40, 110 mg/kg b.w., respectively) intraperitoneally. BSEt (200 mg/kg) was administered to diabetic rats for 28 days. The effect of extract on blood glucose, plasma insulin, total haemoglobin, glycosylated haemoglobin, liver glycogen and carbohydrate metabolism regulating enzymes of liver was studied in diabetic rats.
  
  
  RESULTS
  BSEt significantly reduced the blood glucose and glycosylated haemoglobin levels and significantly increased the total haemoglobin, plasma insulin and liver glycogen levels in diabetic rats. It also increased the hexokinase activity and decreased glucose-6-phosphatase, fructose-1, 6-bisphosphatase activities in diabetic rats.
  
  
  CONCLUSIONS
  The results of our study suggest that BSEt possesses a promising effect on STZ-nicotinamide-induced diabetes.
authors.affiliation: Department of Pharmacology, Annamalai University, Annamalai Nagar, Chidambaram-608 002, India.
authors.forename: Prabu K
authors.initials: PK
authors.lastname: Ananda
authors.forename: C T
authors.initials: CT
authors.lastname: Kumarappan
authors.forename: Christudas
authors.initials: C
authors.lastname: Sunil
authors.forename: V K
authors.initials: VK
authors.lastname: Kalaichelvan
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004798:Enzymes / Q000032:analysis; D006442:Glycated Hemoglobin / Q000032:analysis; D006003:Glycogen / Q000032:analysis; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008297:Male; D009536:Niacinamide / Q000633:toxicity*; D065825:Oxalidaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D010949:Plasma / Q000737:chemistry; D017208:Rats, Wistar; D013311:Streptozocin / Q000633:toxicity*; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D004798:Enzymes; D006442:Glycated Hemoglobin; D006003:Glycogen; D007004:Hypoglycemic Agents; D007328:Insulin; D009536:Niacinamide; D010936:Plant Extracts; D013311:Streptozocin
keywords: Biophytum sensitivum; Carbohydrate metabolism; Diabetes mellitus; Streptozotocin-nicotinamide