title: Lifestyle intervention improves lipoprotein particle size and distribution without weight loss in obese Latino adolescents.
abstract: Childhood obesity is associated with a pro-atherogenic phenotype contributing to increased cardiovascular disease (CVD) risk. This single-arm pilot study examined the effects of a lifestyle intervention on lipoprotein particle size and cholesterol distribution in obese Latino adolescents. Fifteen obese Latino adolescents (15.0 ± 1.0 years) completed a 12-week nutrition education and exercise intervention. Low-density lipoprotein (LDL) particle size and distribution of cholesterol in lipoprotein subclasses were determined via polyacrylamide gel electrophoresis. The intervention resulted in increases in mean LDL particle size (269.3 ± 3.4 to 271.6 ± 2.9 Å, P = 0.0003) and cholesterol in large high-density lipoprotein (HDL) subfractions (22.4 ± 11.2 to 26.8 ± 10.6% area, P = 0.007) along with decreases of cholesterol in small LDL (1.6 ± 2.0 to 0.6 ± 1.2% area, P < 0.01) and HDL subfractions (23.2 ± 9.4 to 19.0 ± 6.7% area, P = 0.05). These improvements were observed independent of changes in weight (90.7 ± 26.2 to 89.9 ± 27.8 kg, P > 0.05) and suggest that lifestyle modification in obese youth may reduce cardiovascular risk by shifting lipoprotein particle size and cholesterol distribution to a less atherogenic phenotype.
authors.affiliation: School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Ryder
authors.forename: S
authors.initials: S
authors.lastname: Vega-López
authors.forename: R
authors.initials: R
authors.lastname: Ortega
authors.forename: Y
authors.initials: Y
authors.lastname: Konopken
authors.forename: G Q
authors.initials: GQ
authors.lastname: Shaibi
mesh_terms: D000293:Adolescent; D050197:Atherosclerosis / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D006266:Health Education; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009752:Nutritional Status; D010316:Particle Size; D010349:Patient Compliance; D063766:Pediatric Obesity / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D010641:Phenotype; D010865:Pilot Projects; D012307:Risk Factors; D040242:Risk Reduction Behavior; D014280:Triglycerides / Q000097:blood*; D015431:Weight Loss
chemical_list: D008074:Lipoproteins; D014280:Triglycerides
keywords: Atherosclerosis; LDL size; cholesterol distribution; obesity.