title: Autogenous fecal peritonitis in Wistar rats with permanent bilateral carotid occlusion: morbidity, mortality and microbiological response.
abstract: OBJECTIVE
  To investigate morbidity, mortality and microbiological response to fecal peritonitis induced in Wistar rats with permanent bilateral carotid ligation (PBCL).
  
  
  METHODS
  Fecal peritonitis was induced in 30 rats, with 10 animals in each group: Group1 - normal young animals; Group2 - normal mature animals; and Group3 - rats with PBCL after four months postoperative follow-up. Peritonitis was induced with 10% stool suspension. Morbidity and mortality were evaluated. The survival animals after seven days were euthanized for tests. For microbiological studies blood were collected from the carotids and right ventricle; and fragments of lung and peritoneum.
  
  
  RESULTS
  The morbidity and mortality of young animals were significantly lower than in mature animals with and without PBCL. There was no difference in morbidity and mortality among mature rats with and without PBCL. The diversity of microorganisms producing septicemia was similar to native micro biota of the large bowel.
  
  
  CONCLUSIONS
  The immune response was more efficient in young animals, represented by significant less morbidity and no natural mortality. PBLC did not affect morbidity and mortality in mature rats. The immune response to fecal peritonitis has age as an independent predictor.
authors.affiliation: Postgraduate Program in Surgery, Health Sciences Center, UFPE. Associate Professor, Department of Ophthalmology, Medical Sciences Faculty of Campina Grande (FCM-CG), Campina Grande-PB, Brazil.
authors.forename: Diego Nery Benevides
authors.initials: DN
authors.lastname: Gadelha
authors.forename: Maria Cecília Santos Cavalcanti
authors.initials: MC
authors.lastname: Melo
authors.forename: Thárcia Kiara Beserra
authors.initials: TK
authors.lastname: Oliveira
authors.forename: Carlos Teixeira
authors.initials: CT
authors.lastname: Brandt
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000276:immunology / Q000473:pathology*; D005243:Feces; D008168:Lung / Q000276:immunology / Q000473:pathology; D008297:Male; D010537:Peritoneum / Q000276:immunology / Q000473:pathology*; D010538:Peritonitis / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D000267:Tissue Adhesions