title: The characteristics of short- and long-term surviving Shiba dogs with chronic enteropathies and the risk factors for poor outcome.
abstract: BACKGROUND
  The objectives of this study were to investigate the differences in the characteristics of short- and long-term surviving dogs, and the factors that predict poor outcome in Shiba dogs with chronic enteropathies (CE).
  
  
  METHODS
  A total of 25 Shiba dogs were included in this study, and classified as either short-term (≤6 months) survivors (Ss; n=16) or long-term (>6 months) survivors (Ls; n=9). The clinical and clinicopathological variables, histopathology, response to therapy, and outcomes were investigated between groups. Furthermore, these factors were tested for their ability to predict poor outcome.
  
  
  RESULTS
  All CE dogs were diagnosed as having inflammatory bowel disease (IBD) with lymphocytic-plasmacytic enteritis (LPE). Age and canine inflammatory bowel disease activity index (CIBDAI) were significantly higher in the Ss group than in the Ls group (age: p = 0.035, CIBDAI: p = 0.018), as determined via univariate logistic regression analysis. According to receiver operator characteristic (ROC) curve analysis, the best predictors of poor outcome were age and CIBDAI, with the cutoffs determined as 7 years and 9 points, respectively. The majority of the cases (84%) responded to initial treatment; in particular, 75% of dogs in Ss group responded to therapy. The time to response (days) to the initial treatment in the Ss group (median 42.5 days, range: 20-91 days) was significantly shorter than that of the Ls group (median 285 days, range: 196-1026 days). Approximately half (55.5%) of the dogs in the Ls group died due to relapse of CE.
  
  
  CONCLUSIONS
  This study suggested that there is a high risk of early mortality in Shiba dogs with CE, particularly if the dogs are older (>7 years) and have a high CIBDAI score (>9 points). There appears to be a possibility of early mortality even if the initial treatment was efficacious. Furthermore, Shiba dogs with CE that become less responsive to initial therapy in the short-term (approximately 3 months) are more likely to have an early mortality. Thus, it is necessary to follow-up Shiba dogs with CE in the long-term, as approximately half of the long-term survivors eventually died due to a relapse of the signs.
authors.affiliation: Department of Veterinary Medicine, Laboratory of Comprehensive Veterinary Clinical Studies, Faculty of Bioresources, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Okanishi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Sano
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Yamaya
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kagawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Watari
mesh_terms: D000375:Aging; D000818:Animals; D001835:Body Weight; D002908:Chronic Disease; D004283:Dog Diseases / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D004285:Dogs; D004751:Enteritis / Q000401:mortality / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D005260:Female; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome