title: Cardiac syncope due to pain: report of a case responsive to duloxetine treatment.
abstract: Neurocardiogenic syncope comprises situations triggered by neurological reflexes resulting in abnormal responses of the neurocardiovascular system that cause loss of consciousness. A vast number of clinical conditions may cause this disorder including pain, defecation, micturition, swallowing, cough, sudden fear or excitement, exercise, and long-time standing. Treatment options for syncope prevention are not satisfactory. Several agents were used for pharmacological treatment without success. Selective inhibitors of neuronal norepinephrine transporter (NET) like duloxetine may play a role in neurally mediated syncope by increasing synaptic norepinephrine levels. Therefore, we report the effect of duloxetine in a patient with pain-induced syncope resistant to standard regimens.
authors.affiliation: Department of Neurology, Bursa Military Hospital, Bursa, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Kaplan
authors.forename: S A
authors.initials: SA
authors.lastname: Kocaman
authors.forename: M E
authors.initials: ME
authors.lastname: Durakoğlugil
authors.forename: E
authors.initials: E
authors.lastname: Kaya
authors.forename: M G
authors.initials: MG
authors.lastname: Senol
mesh_terms: D000328:Adult; D000700:Analgesics / Q000627:therapeutic use; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D010146:Pain / Q000150:complications* / Q000188:drug therapy*; D013575:Syncope / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D013876:Thiophenes / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride