title: Hydrodynamics of hemostasis in sickle-cell disease.
abstract: Vaso-occlusion, the stoppage of blood flow in sickle-cell disease, is a complex dynamical process spanning multiple time and length scales. Motivated by recent ex vivo microfluidic measurements of hemostasis using blood from sickle-cell patients, we develop a multiphase model that couples the kinetics and hydrodynamics of a flowing suspension of normal and sickled cells in a fluid. We use the model to derive expressions for the cell velocities and concentrations that quantify the hydrodynamics of hemostasis, and provide simple criteria as well as a phase diagram for occlusion, consistent with our simulations and earlier observations.
authors.affiliation: School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: S I A
authors.initials: SI
authors.lastname: Cohen
authors.forename: L
authors.initials: L
authors.lastname: Mahadevan
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood* / Q000473:pathology; D006451:Hemoglobin, Sickle / Q000378:metabolism; D006487:Hemostasis; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000379:methods; D008954:Models, Biological
chemical_list: D006451:Hemoglobin, Sickle