title: Neuroendocrine tumour at the carina of a dog.
abstract: A 10-year-old, neutered female, crossbred pit bull terrier was presented for cough, haemoptysis and rapidly progressive respiratory difficulty. Thoracic radiographs suggested a soft tissue density at the carina and bronchoscopy revealed a large, broad-based mass obstructing the entire left mainstem bronchus and half of the entrance to the right mainstem bronchus. Microscopically, the mass consisted of neoplastic cells that were packeted into small nests and had strong granular cytoplasmic immunoreactivity to synaptophysin and chromogranin A. Cytoplasmic neurosecretory granules stained strongly by the Grimelius method. A diagnosis of obstructive neuroendocrine tumour was made.
authors.affiliation: William R. Pritchard Veterinary Medical Teaching Hospital, University of California at Davis, Davis, CA, USA.
authors.forename: E N
authors.initials: EN
authors.lastname: Gould
authors.forename: L R
authors.initials: LR
authors.lastname: Johnson
authors.forename: R P
authors.initials: RP
authors.lastname: Traslavina
authors.forename: F C
authors.initials: FC
authors.lastname: Mohr
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000473:pathology / Q000662:veterinary*; D018358:Neuroendocrine Tumors / Q000473:pathology / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor
keywords: carina; dog; immunohistochemistry; neuroendocrine tumour