title: Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats.
abstract: OBJECTIVE
  To study the antioxidant efficacy of Commiphora mukul (C. mukul) gum resin ethanolic extract in streptozotocin (STZ) induced diabetic rats.
  
  
  METHODS
  THE MALE WISTAR ALBINO RATS WERE RANDOMLY DIVIDED INTO FOUR GROUPS OF EIGHT ANIMALS EACH: Control group (C), CM-treated control group (C+CMEE), Diabetic control group (D), CM- treated diabetic group (D+CMEE). Diabetes was induced by intraperitoneal injection of STZ (55 mg/kg/ bwt). After being confirmed the diabetic rats were treated with C. mukul gum resin ethanolic extract (CMEE) for 60 days. The biochemical estimations like antioxidant, oxidative stress marker enzymes and hepatic marker enzymes of tissues were performed.
  
  
  RESULTS
  The diabetic rats showed increased level of enzymatic activities aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) in liver and kidney and oxidative markers like lipid peroxidation (LPO) and protein oxidation (PO) in pancreas and heart. Antioxidant enzyme activities were significantly decreased in the pancreas and heart compared to control group. Administration of CMEE (200 mg/kg bw) to diabetic rats for 60 days significantly reversed the above parameters towards normalcy.
  
  
  CONCLUSIONS
  In conclusion, our data indicate the preventive role of C. mukul against STZ-induced diabetic oxidative stress; hence this plant could be used as an adjuvant therapy for the prevention and/or management of diabetes and aggravated antioxidant status.
authors.affiliation: Department of Biochemistry, Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India.
authors.forename: B
authors.initials: B
authors.lastname: Ramesh
authors.forename: R
authors.initials: R
authors.lastname: Karuna
authors.forename: Reddy S
authors.initials: RS
authors.lastname: Sreenivasa
authors.forename: K
authors.initials: K
authors.lastname: Haritha
authors.forename: Mangala D
authors.initials: MD
authors.lastname: Sai
authors.forename: Bhusana Rao B
authors.initials: BR
authors.lastname: Sasi
authors.forename: D
authors.initials: D
authors.lastname: Saralakumari
mesh_terms: D000410:Alanine Transaminase / Q000032:analysis; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000032:analysis; D029744:Commiphora / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism; D010088:Oxidoreductases / Q000032:analysis; D010179:Pancreas / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D010088:Oxidoreductases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Antioxidants; Commiphora mukul; Lipid peroxidation; Streptozotocin