title: Distribution of blood and tissue concentrations in rats by inhalation exposure to 1,2-dichloroethane.
abstract: The compound 1,2-dichloroethane (DCE) is a ubiquitous environmental contaminant. The primary route of exposure of humans to DCE is inhalation of its vapor. The present investigation was undertaken to determine the distribution and accumulation of DCE in the blood, lung, liver, brain, kidney and abdominal fat of rats during and after inhalation exposure. Male rats were exposed to 160 ppm (v/v) of DCE vapor for 360 min and the concentrations of DCE in the blood and tissues during the inhalation exposure period and after the end of the exposure period were measured. DCE accumulation in the abdominal fat was much greater than that in the blood and other tissues. The information we obtained in this study is useful basic data pertaining to the pharmacokinetics of DCE and DCE-mediated carcinogenicity: Our results suggest that one of the factors involved in the induction of peritoneal tumors in rats exposed to DCE vapor by inhalation is DCE accumulation in the abdominal fat.
authors.affiliation: Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano, Kanagawa, Japan. m-take@jisha.or.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Take
authors.forename: Kenji
authors.initials: K
authors.lastname: Takanobu
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Haresaku
authors.forename: Michiharu
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Kasuke
authors.initials: K
authors.lastname: Nagano
authors.forename: Seigo
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Shoji
authors.initials: S
authors.lastname: Fukushima
mesh_terms: D000393:Air Pollutants / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005025:Ethylene Dichlorides / Q000097:blood / Q000378:metabolism*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D019570:Inhalation Exposure; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution
chemical_list: D000393:Air Pollutants; D005025:Ethylene Dichlorides; C024565:ethylene dichloride