title: Neurologic melioidosis in an imported pigtail macaque (Macaca nemestrina).
abstract: Burkholderia pseudomallei is the cause of melioidosis in humans and other animals. Disease occurs predominately in Asia and Australia. It is rare in North America, and affected people and animals typically have a history of travel to (in human cases) or importation from (in animal cases) endemic areas. We describe the gross and histopathologic features and the microbiologic, molecular, and immunohistochemical diagnoses of a case of acute meningoencephalomyelitis and focal pneumonia caused by B. pseudomallei infection in a pigtail macaque that was imported from Indonesia to the United States for research purposes. This bacterium has been classified as a Tier 1 overlap select agent and toxin; therefore, recognition of pathologic features, along with accurate and timely confirmatory diagnostic testing, in naturally infected research animals is imperative to protect animals and personnel in the laboratory animal setting.
authors.affiliation: Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop G 32, Atlanta, GA 30333, USA. Email: jritter@cdc.gov.
authors.forename: J M
authors.initials: JM
authors.lastname: Ritter
authors.forename: S
authors.initials: S
authors.lastname: Sanchez
authors.forename: T L
authors.initials: TL
authors.lastname: Jones
authors.forename: S R
authors.initials: SR
authors.lastname: Zaki
authors.forename: C P
authors.initials: CP
authors.lastname: Drew
mesh_terms: D000818:Animals; D001921:Brain / Q000382:microbiology / Q000473:pathology; D016957:Burkholderia pseudomallei / Q000235:genetics / Q000302:isolation & purification*; D004679:Encephalomyelitis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D007214:Indonesia; D008254:Macaca nemestrina; D008554:Melioidosis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008590:Meningoencephalitis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D008992:Monkey Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D016133:Polymerase Chain Reaction / Q000662:veterinary; D013116:Spinal Cord / Q000382:microbiology / Q000473:pathology; D014481:United States
keywords: Burkholderia pseudomallei; PCR; immunohistochemistry; macaque; melioidosis; meningoencephalomyelitis; neurologic