title: Effect of lead acetate toxicity on experimental male albino rat.
abstract: OBJECTIVE
  To evaluate the effect of different doses of lead acetate (1/20, 1/40 and 1/60 of LD50) on body weight gain, blood picture, plasma protein profile and the function of liver, kidney and thyroid gland.
  
  
  METHODS
  Male albino rats were divided into four groups, the first group represented the health control animals, while the second, third and fourth groups were ingested orally with sub lethal doses of lead acetate (1/20, 1/40 and 1/60) of the oral LD50, respectively. One dose was ingested every two days during the experimental period (14 weeks) including the adaptation time. Blood was collected and used for all analysis.
  
  
  RESULTS
  The results showed that, the ingestion of Pb(2+) induced significant stimulation in glutamic-pyruvic transaminase (ALT) and glutamic-oxalacetic transaminease (AST) activity. Also, total soluble protein and albumin contents of plasma were significantly decreased, while the content of globulin was changed by the Pb(2+) treatments. The cholinesterase activity was inhibited, but the activities of alkaline and acid phosphates and lactate dehydrogenase were stimulated, while plasma glucose level was elevated as a result of lead acetate intoxication. In case of blood picture, Pb(2+) ingestion reduced the contents of hemoglobin and RBCs count of intoxicated rat's blood and the plasma levels of T3, T4 and blood WBCs count were decreased.
  
  
  CONCLUSIONS
  It can be concluded that lead acetate has harmful effect on experimental male albino rats. Therefore, the present work advises people to prevent exposure to the lead compound to avoid injurious hazard risk.
authors.affiliation: Department of Economic Entomology and Pesticides, Faculty of Agriculture, Cairo University.
authors.forename: Nabil M
authors.initials: NM
authors.lastname: Ibrahim
authors.forename: Esam A
authors.initials: EA
authors.lastname: Eweis
authors.forename: Hossam S
authors.initials: HS
authors.lastname: El-Beltagi
authors.forename: Yasmin E
authors.initials: YE
authors.lastname: Abdel-Mobdy
mesh_terms: D000818:Animals; D001773:Blood Cells; D001774:Blood Chemical Analysis; D007677:Kidney Function Tests; D007855:Lead Poisoning / Q000473:pathology* / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D009942:Organometallic Compounds / Q000633:toxicity*; D017207:Rats, Sprague-Dawley; D013960:Thyroid Function Tests
chemical_list: D009942:Organometallic Compounds; C008261:lead acetate
keywords: ALT; AST; Cholinesterase; Hemoglobin; Intoxication; Lead; Lead acetate; T3; T4; Toxicity