title: [Assessment of Hungarian ESA and G-CSF treatments to national and international guidelines and protocols].
abstract: Chemotherapy induced neutropenia (CIN), febrile neutropenia (FN), chemotherapy induced anemia (CIA) frequently occur following myelosuppressive chemotherapy and are associated with morbidity, mortality, costs, and relative dose intensity (RDI), hence influencing overall survival (OS). Given prophylactically, granulocyte colony-stimulating factors (G-CSFs) can stimulate neutrophil production and depletion, they may thus reduce FN incidence when following chemotherapy. Erythropoietins are widely used to treat chemotherapy induced anemia. Several guidelines have been published to help onco-hematologists design their supportive therapy. The aim of our study was to assess the guidelines concerning everyday routine in supportive care. The final conclusion is that the Hungarian therapy support guidelines are up to date, are highly compliant with international standards [ASCO (1), EORTC (2), ESMO (3, 4), NCCN (5-7)], and that the clinicians have a deep understanding and comprehensive usage in their everyday practice.
authors.affiliation: Belgyógyászati Intézet, MISEK Kft., Hematológiai Osztály, Miskolc, Hungary. drzsoltnagy@gmail.com
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Nagy
mesh_terms: D000284:Administration, Oral; D000740:Anemia / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy*; D002985:Clinical Protocols / Q000592:standards; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D004921:Erythropoietin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005334:Fever / Q000209:etiology; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006397:Hematinics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006405:Hematology / Q000379:methods / Q000592:standards / Q000639:trends; D006801:Humans; D006814:Hungary; D007391:International Cooperation; D058085:Iron Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D008495:Medical Oncology / Q000379:methods / Q000592:standards / Q000639:trends; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications; D017410:Practice Guidelines as Topic; D011795:Surveys and Questionnaires
chemical_list: D006397:Hematinics; D058085:Iron Compounds; D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor