title: Detection of cancer stem cell markers in sarcomas.
abstract: The identification of cancer stem cell markers represents one of the very relevant research topics because cancer stem cells play important roles in tumour initiation and progression, as well as during metastasis formation and in relapse of the disease. This article summarises recent knowledge on well-known and putative cancer stem cell markers in various types of bone and soft-tissue sarcomas. Special attention is paid to the detection of CD133, ABC transporters, nestin and aldehyde dehydrogenase that have been intensively studied both in tumour tissues and in sarcoma cell lines during the past few years. Finally, an overview is given of the possible CSC phenotypes provided by functional assays of tumourigenicity.
authors.affiliation: Laboratory of Tumor Biology, Department of Experimental Biology, School of Science, Masaryk University, Brno, Czech Republic. veselska@sci.muni.cz
authors.forename: R
authors.initials: R
authors.lastname: Veselska
authors.forename: J
authors.initials: J
authors.lastname: Skoda
authors.forename: J
authors.initials: J
authors.lastname: Neradil
mesh_terms: D000071916:AC133 Antigen; D018528:ATP-Binding Cassette Transporters / Q000032:analysis; D000444:Aldehyde Dehydrogenase / Q000032:analysis; D015703:Antigens, CD / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007381:Intermediate Filament Proteins / Q000032:analysis; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000032:analysis; D064231:Nestin; D010455:Peptides / Q000032:analysis; D012509:Sarcoma / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D000071916:AC133 Antigen; D018528:ATP-Binding Cassette Transporters; D015703:Antigens, CD; D014408:Biomarkers, Tumor; D006023:Glycoproteins; D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; D064231:Nestin; C000606023:PROM1 protein, human; D010455:Peptides; D000444:Aldehyde Dehydrogenase