title: The use, misuse and abuse of dabigatran.
abstract: The tale of dabigatran sounds some cautionary notes about proper critical appraisal of new randomised controlled trials,care in deciding on the generalisability of results, judicious screening of patients and lessons about the politics around increasingly lucrative drugs. The old lesson of caveat utilitor still holds: let the user beware!
authors.affiliation: University of Newcastle, Newcastle, NSW, Australia. john.attia@newcastle.edu.au
authors.forename: John R
authors.initials: JR
authors.lastname: Attia
authors.forename: Robert
authors.initials: R
authors.lastname: Pearce
mesh_terms: D000329:Advertising; D000925:Anticoagulants / Q000627:therapeutic use; D000991:Antithrombins / Q000008:administration & dosage* / Q000009:adverse effects* / Q000191:economics; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects; D001315:Australia; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000009:adverse effects* / Q000191:economics; D002318:Cardiovascular Diseases / Q000517:prevention & control; D000069604:Dabigatran; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D009203:Myocardial Infarction / Q000453:epidemiology; D018579:Patient Selection; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D016032:Randomized Controlled Trials as Topic; D051437:Renal Insufficiency / Q000150:complications; D012107:Research Design; D015983:Selection Bias; D020521:Stroke / Q000517:prevention & control; D014859:Warfarin / Q000627:therapeutic use; D015091:beta-Alanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000191:economics
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D001562:Benzimidazoles; D010975:Platelet Aggregation Inhibitors; D015091:beta-Alanine; D014859:Warfarin; D000069604:Dabigatran; D001241:Aspirin