title: Discovery and characterization of protein-modifying natural products by MALDI mass spectrometry reveal potent SIRT1 and p300 inhibitors.
authors.affiliation: Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Holzhauser
authors.forename: Anja
authors.initials: A
authors.lastname: Freiwald
authors.forename: Christoph
authors.initials: C
authors.lastname: Weise
authors.forename: Gerd
authors.initials: G
authors.lastname: Multhaup
authors.forename: Chung-Ting
authors.initials: CT
authors.lastname: Han
authors.forename: Sascha
authors.initials: S
authors.lastname: Sauer
mesh_terms: D000107:Acetylation; D001688:Biological Products / Q000494:pharmacology*; D002478:Cells, Cultured; D050881:E1A-Associated p300 Protein / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D061848:Optical Imaging; D010446:Peptide Fragments / Q000378:metabolism*; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013267:Stilbenes / Q000494:pharmacology
chemical_list: D001688:Biological Products; D004791:Enzyme Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings; D010446:Peptide Fragments; C525422:SRT1720; D013267:Stilbenes; D050881:E1A-Associated p300 Protein; C494360:EP300 protein, human; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D000077185:Resveratrol