title: Executive response monitoring and inhibitory control in children with phenylketonuria: effects of expectancy.
abstract: Response monitoring (post-error slowing) and inhibitory control (commission errors) were examined in children with phenylketonuria (PKU) and controls (6-18 years) using Go/No-Go tasks with higher (PKU n = 37; control n = 55) versus lower (PKU n = 24; control n = 25) non-target expectancy. On both tasks children with PKU exhibited impaired monitoring and inhibitory control, but the post-error slowing pattern was different. With higher expectancy children with PKU slowed more (less efficient monitoring) and with lower expectancy slowed less (less monitoring) than controls. No effects of age or phenylalanine level were noted. These results indicate that expectancy differentially effects monitoring and inhibitory control in PKU.
authors.affiliation: Department of Psychology, Washington University, St. Louis, Missouri, USA.
authors.forename: Gabriel C
authors.initials: GC
authors.lastname: Araujo
authors.forename: Shawn E
authors.initials: SE
authors.lastname: Christ
authors.forename: Dorothy K
authors.initials: DK
authors.lastname: Grange
authors.forename: Robert D
authors.initials: RD
authors.lastname: Steiner
authors.forename: Carla
authors.initials: C
authors.lastname: Coleman
authors.forename: Evonne
authors.initials: E
authors.lastname: Timmerman
authors.forename: Desirée A
authors.initials: DA
authors.lastname: White
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D003072:Cognition Disorders / Q000209:etiology*; D003657:Decision Making / Q000502:physiology; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D033182:Intention; D008297:Male; D009483:Neuropsychological Tests; D010649:Phenylalanine / Q000378:metabolism; D010661:Phenylketonurias / Q000150:complications* / Q000523:psychology*; D011930:Reaction Time / Q000502:physiology; D012044:Regression Analysis
chemical_list: D010649:Phenylalanine