title: Signals controlling Cajal body assembly and function.
abstract: Cajal bodies (CBs) are subnuclear domains that participate in the biogenesis of small nuclear ribonucleoproteins (snRNPs) and telomerase. CBs are found in cells with high splicing demands, such as neuronal and cancer cells. The purpose of this review is to highlight what is known about the signals that impact the formation and activity of CBs. Particular attention is paid to phosphorylation as a major regulator of CB formation and composition, but a non-biochemical mediated pathway (mechanotransduction) that impacts CBs is also discussed. Amongst the CB components, recently published work on coilin (the CB marker protein) strongly suggests that this protein, and the CB by extension, is a global sensor that responds to environmental signals. Disruption of these signals, which would result in a decreased capacity to generate snRNPs and telomerase, is predicted to be beneficial in the treatment of cancer.
authors.affiliation: Department of Biochemistry, The University of Mississippi Medical Center, Jackson, MS 39216 4505, USA. mhebert@umc.ed
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hebert
mesh_terms: D000818:Animals; D020541:Coiled Bodies / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D010766:Phosphorylation; D017411:Ribonucleoproteins, Small Nuclear / Q000096:biosynthesis / Q000378:metabolism*; D019098:Telomerase / Q000096:biosynthesis / Q000378:metabolism
chemical_list: D009687:Nuclear Proteins; D017411:Ribonucleoproteins, Small Nuclear; C068921:p80-coilin; D019098:Telomerase