title: Urinary α- and π-glutathione s-transferases for early detection of acute kidney injury following cardiopulmonary bypass.
abstract: BACKGROUND
  Urinary α-GST and π-GST are renal tubular leakage markers.
  
  
  OBJECTIVE
  To evaluate the performance characteristics of these markers for the early detection of acute kidney injury (AKI).
  
  
  METHODS
  Multicenter prospective cohort study of 252 adults undergoing cardiopulmonary bypass (CPB).
  
  
  RESULTS
  AKI developed in 72 patients. The 2 h post-CPB π-GST level modestly predicted the development of AKI, including higher stages of severity, whereas α-GST did not.
  
  
  CONCLUSIONS
  Small number of events and absence of subsequent post-operative biomarker measurements.
  
  
  CONCLUSIONS
  Among adults undergoing CPB, urinary π-GST outperformed α-GST for predicting AKI, but neither marker displayed good discrimination.
authors.affiliation: Kidney and Dialysis Research Laboratory, Department of Medicine, Division of Nephrology, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA.
authors.forename: Paweena
authors.initials: P
authors.lastname: Susantitaphong
authors.forename: Mary C
authors.initials: MC
authors.lastname: Perianayagam
authors.forename: Hocine
authors.initials: H
authors.lastname: Tighiouart
authors.forename: Diana
authors.initials: D
authors.lastname: Kouznetsov
authors.forename: Orfeas
authors.initials: O
authors.lastname: Liangos
authors.forename: Bertrand L
authors.initials: BL
authors.lastname: Jaber
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology; D000368:Aged; D015415:Biomarkers / Q000652:urine*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D005260:Female; D005982:Glutathione Transferase / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D005982:Glutathione Transferase