title: Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol.
abstract: Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Jeong
authors.forename: John J
authors.initials: JJ
authors.lastname: Schmidt
authors.forename: Richie E
authors.initials: RE
authors.lastname: Kohman
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Zill
authors.forename: Ross J
authors.initials: RJ
authors.lastname: DeVolder
authors.forename: Cartney E
authors.initials: CE
authors.lastname: Smith
authors.forename: Mei-Hsiu
authors.initials: MH
authors.lastname: Lai
authors.forename: Artem
authors.initials: A
authors.lastname: Shkumatov
authors.forename: Tor W
authors.initials: TW
authors.lastname: Jensen
authors.forename: Lawrence G
authors.initials: LG
authors.lastname: Schook
authors.forename: Steven C
authors.initials: SC
authors.lastname: Zimmerman
authors.forename: Hyunjoon
authors.initials: H
authors.lastname: Kong
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000293:injuries / Q000378:metabolism*; D057510:Endovascular Procedures / Q000379:methods; D005990:Glycerol / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007267:Injections; D007962:Leukocytes / Q000166:cytology; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism
chemical_list: D010455:Peptides; D011108:Polymers; C043941:polyglycerol; D005990:Glycerol