title: The role of low-molecular-weight protein tyrosine phosphatase (LMW-PTP ACP1) in oncogenesis.
abstract: Protein tyrosine phosphorylation is a crucial cellular event that is involved in the most important processes of cellular metabolism. Low-molecular-weight protein tyrosine phosphatase (LMW-PTP) is a tyrosine phosphatase that presents two active distinct isoforms and is regulated through cysteine oxidation and tyrosine phosphorylation. This enzyme has been linked to tumorigenesis, but its role is considered controversial: it may be considered oncogenic or anti-oncogenic depending on its interaction with different substrates. Furthermore, recent studies have demonstrated that LMW-PTP is involved in epithelial cell migration, a characteristic of tumor cells. This fact strengthens the importance of this enzyme in the oncogenic process and opens new avenues for future research. The study of LMW-PTP and its pathways may enhance therapeutic strategies that target tyrosine phosphorylation and its substrates. In this review, we try to clarify the importance of this protein in carcinogenesis through the analysis of LMW-PTP interaction with different substrates.
authors.affiliation: Genetics Laboratory, Cardiology Center, Lisbon Medical School, Av. Prof. Egas Moniz, Edificio Egas Moniz, P1C 1649-028, Lisbon, Portugal.
authors.forename: Irina
authors.initials: I
authors.lastname: Alho
authors.forename: Luís
authors.initials: L
authors.lastname: Costa
authors.forename: Manuel
authors.initials: M
authors.lastname: Bicho
authors.forename: Constança
authors.initials: C
authors.lastname: Coelho
mesh_terms: D002465:Cell Movement; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D010084:Oxidation-Reduction; D010766:Phosphorylation; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism
chemical_list: D011518:Proto-Oncogene Proteins; D020794:Receptor Protein-Tyrosine Kinases; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases