title: [Leptin: Involvement in the pathophysiology of breast cancer].
abstract: More than one million new cases of breast cancer are diagnosed each year worldwide and more than 400,000 deaths occur due to this pathology. Obesity is a risk factor for postmenopausal breast cancer and the place held by the adipose tissue and secretions (i.e. adipokines) begins to be recognized. Indeed, firstly, plasma adipokine levels, modulated in obesity situation, could have effects "remotely" on mammary carcinogenesis and, secondly, breast cancer cells are surrounded by adipocyte microenvironment, which is probably more important in the case of obesity, and may be locally influenced by it. In this context, leptin appears to be strongly involved in mammary carcinogenesis and may contribute to the angiogenesis process and local pro-inflammatory mechanisms, especially in obese patients for whom increased metastatic potential and risk of mortality are described.
authors.affiliation: Clermont université, université d'Auvergne, UFR pharmacie, 28, place Henri-Dunant, 63000 Clermont-Ferrand, France. m-paule.vasson@udamail.fr
authors.forename: Florence
authors.initials: F
authors.lastname: Caldefie-Chézet
authors.forename: Virginie
authors.initials: V
authors.lastname: Dubois
authors.forename: Laetitia
authors.initials: L
authors.lastname: Delort
authors.forename: Adrien
authors.initials: A
authors.lastname: Rossary
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Vasson
mesh_terms: D017667:Adipocytes / Q000378:metabolism / Q000502:physiology; D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D005260:Female; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000401:mortality
chemical_list: D020738:Leptin