title: Ceftaroline - a cause for neutropenia.
abstract: OBJECTIVE
  The US Food and Drug Administration approved ceftaroline in 2010 for the treatment of community-acquired pneumonia and skin and soft-tissue infections. The most common adverse reactions are diarrhoea, nausea and rash. To present the first case of neutropenia directly related to ceftaroline.
  
  
  METHODS
  A 90-year-old female was given ceftaroline for treatment of a pneumonia complicated by methicillin-resistant Staphylococcus aureus bacteraemia and possible vertebral osteomyelitis. After 25 days of ceftaroline, she developed neutropenia. Ceftaroline was discontinued and her white blood cell count returned to normal within one week.
  
  
  CONCLUSIONS
  Although neutropenia is a potential cephalosporin class effect, we present the first case of neutropenia directly related to ceftaroline. Agranulocytosis and neutropenia are rare, yet potentially life-threatening adverse effects of cephalosporins. Healthcare providers should be aware of the potential for ceftaroline to cause neutropenia, particularly in patients treated for greater than two weeks.
authors.affiliation: Division of Infectious Diseases, East Carolina University - Brody School of Medicine, Greenville, NC 27834, USA. RamzyRimawi@hotmail.com
authors.forename: R H
authors.initials: RH
authors.lastname: Rimawi
authors.forename: A
authors.initials: A
authors.lastname: Frenkel
authors.forename: P P
authors.initials: PP
authors.lastname: Cook
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D002511:Cephalosporins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009503:Neutropenia / Q000139:chemically induced* / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000097:blood / Q000188:drug therapy; D000097583:Ceftaroline
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000097583:Ceftaroline
keywords: agranulocytosis; antibiotics; ceftaroline; drug information; neutropenia