title: [Expressions of bone morphogenetic protein 2 and runt-related transcription factor 2 and microarchitecture of trabecular bone periacetabula in adult patients with developmental dysplasia of hip].
abstract: OBJECTIVE
  To explore the expressions of bone morphogenetic protein 2 (BMP-2) and runt-related transcription facotr 2 (Runx2) and microarchitecture of trabecular bone periacetabula in adult patients with developmental dysplasia of the hip (DDH).
  
  
  METHODS
  Between March and September 2008, the trabecular bone periacetabulum was collected from 8 patients with DDH who were scheduled for total hip arthroplasty (aged 37-55 years, 3 males and 5 females, trial group) and from 8 patients with avascular necrosis of the femoral head (Ficat stage II) who were scheduled for hip resurfacing arthroplasty (aged 36-55 years, 3 males and 5 females, control group). The expressions of BMP-2 and Runx2 in the trabecular bone were determined by real-time quantitative PCR, and the microarchitecture was observed by micro-CT and the following parameters were determined: bone volume/total volume (BV/TV), connectivity density (Conn.Dens), trabecular number (Tb.N), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), and structure model index (SMI).
  
  
  RESULTS
  The expressions of BMP-2 and Runx2 were significantly lower in trial group than in control group (P < 0.05). The micro-CT showed sparse trabecular bone in trial group and dense trabecular bone in control group. BV/TV and Tb.N in trial group were significantly lower than those in control group, and SMI and Tb.Sp in trial group were significantly higher than those in control group (P < 0.05); there was no significant difference in Conn.Dens and Tb.Th between 2 groups (P > 0.05).
  
  
  CONCLUSIONS
  The trabecular bone is in a low metabolism condition and its microarchitecture is tendency to be osteoporosis trabecualr bone in adult patients with DDH. It may be related with the acetabular component loosening after total hip arthroplasty.
authors.affiliation: Department of Orthopedics, Second Hospital Affiliated to the Medical College of Xi'an Jiaotong University, Xi'an Shaanxi, 710004, P.R.China.
authors.forename: Ruiyu
authors.initials: R
authors.lastname: Liu
authors.forename: Kunzheng
authors.initials: K
authors.lastname: Wang
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Li
authors.forename: Chuanyi
authors.initials: C
authors.lastname: Bai
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Wang
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Dang
mesh_terms: D000077:Acetabulum / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000648:ultrastructure; D000328:Adult; D019644:Arthroplasty, Replacement, Hip; D015519:Bone Density / Q000502:physiology; D055396:Bone Morphogenetic Protein 2 / Q000378:metabolism*; D050659:Core Binding Factor Alpha 1 Subunit / Q000378:metabolism*; D005260:Female; D005270:Femur Head / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D006617:Hip Dislocation / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D011475:Prosthesis Failure; D014057:Tomography, X-Ray Computed
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D050659:Core Binding Factor Alpha 1 Subunit; C493709:RUNX2 protein, human