title: Clinically significant differences exist between curves in operative idiopathic early-onset scoliosis and adolescent idiopathic scoliosis.
abstract: METHODS
  Retrospective analysis.
  
  
  OBJECTIVE
  To determine if statistically significant differences exist between operative idiopathic early-onset scoliosis (IEOS) and adolescent idiopathic scoliosis (AIS) in primary curve characteristics, stable vertebra, kyphosis, or lumbar deformity and, if so, to identify the clinical significance of these differences.
  
  
  BACKGROUND
  To our knowledge, no study has statistically compared radiographical measures of operative IEOS and AIS.
  
  
  METHODS
  We identified operative patients (60, IEOS; 1537, AIS) in 2 multicenter databases and measured preoperative radiographical parameters of interest. The measurements were compared using the Student t test and other appropriate statistical methods (significance, P = 0.05).
  
  
  RESULTS
  The IEOS and AIS groups were significantly different in primary curve magnitude (70° ± 20° vs. 54° ± 13°, respectively; P < 0.001), stable vertebra location (L3.0 ± 1.4 vs. L2.1 ± 2.2, respectively; P = 0.001), and T2 to T12 kyphosis (40° ± 15° vs. 31° ± 13°, respectively; P < 0.001). Distribution of major curve apex was unimodal centered close to the thoracolumbar junction in IEOS versus bimodal in AIS. Primary curve type was thoracic in 83% and 79% and thoracolumbar/lumbar in 17% and 21% of patients with IEOS and AIS, respectively. When the overall cohorts were separated into curve types and these subsets were compared, statistically significant differences were found between IEOS and AIS in thoracic primary curves (apex, magnitude, direction, proximal and distal Cobb vertebrae, and lumbar deformity) and thoracolumbar/lumbar primary curves (magnitude).
  
  
  CONCLUSIONS
  Significant radiographical differences exist between operative IEOS and AIS curves. IEOS curves are greater in magnitude, more kyphotic, less well compensated, and have a more caudal apex and stable vertebra. These findings suggest that younger patients may require more distal instrumentation and that proximal fixation techniques should consider the additional pullout forces created by the greater kyphosis.
authors.affiliation: Department of Orthopaedic Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: McElroy
authors.forename: Paul D
authors.initials: PD
authors.lastname: Sponseller
authors.forename: Sara K
authors.initials: SK
authors.lastname: Fuhrhop
authors.forename: Colin J
authors.initials: CJ
authors.lastname: Russell
authors.forename: Peter O
authors.initials: PO
authors.lastname: Newton
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Marks
authors.forename: James O
authors.initials: JO
authors.lastname: Sanders
authors.forename: Muharrem
authors.initials: M
authors.lastname: Yazici
authors.forename: Jeff B
authors.initials: JB
authors.lastname: Pawelek
authors.forename: Behrooz A
authors.initials: BA
authors.lastname: Akbarnia
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007738:Kyphosis / Q000000981:diagnostic imaging* / Q000601:surgery; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging* / Q000601:surgery; D008297:Male; D019637:Orthopedic Procedures / Q000295:instrumentation / Q000379:methods; D011859:Radiography / Q000379:methods; D012189:Retrospective Studies; D012600:Scoliosis / Q000000981:diagnostic imaging* / Q000601:surgery; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging* / Q000601:surgery