title: Flaxseed (Linum usitatissimum L.) extract as well as (+)-secoisolariciresinol diglucoside and its mammalian derivatives are potent inhibitors of α-amylase activity.
abstract: Type 2 diabetes mellitus (T2DM) is one of the common global diseases. Flaxseed is by far the richest source of the dietary lignans (i.e., secoisolariciresinol diglucoside) which have been shown to delay the development of T2DM in animal models. Herein, we propose the first evidences for a mechanism of action involving the inhibition of the pancreatic α-amylase (EC 3.2.1.1) by flaxseed-derived lignans that could therefore constitute a promising nutraceutical for the prevention and the treatment of T2DM.
authors.affiliation: Laboratoire de Biologie des Ligneux et des Grandes Cultures UPRES EA 1207, Equipe Lignanes des Linacées, Antenne Scientifique Universitaire de Chartres, 21 rue de Loigny la Bataille, F28000 Chartres, France. christophe.hano@univ-orleans.fr
authors.forename: Christophe
authors.initials: C
authors.lastname: Hano
authors.forename: Sullivan
authors.initials: S
authors.lastname: Renouard
authors.forename: Roland
authors.initials: R
authors.lastname: Molinié
authors.forename: Cyrielle
authors.initials: C
authors.lastname: Corbin
authors.forename: Esmatullah
authors.initials: E
authors.lastname: Barakzoy
authors.forename: Joël
authors.initials: J
authors.lastname: Doussot
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lamblin
authors.forename: Eric
authors.initials: E
authors.lastname: Lainé
mesh_terms: D000818:Animals; D002072:Butylene Glycols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019597:Flax / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D007422:Intestines / Q000201:enzymology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D055292:Pancreatic alpha-Amylases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry*; D051381:Rats; D013329:Structure-Activity Relationship; D013552:Swine; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D002072:Butylene Glycols; D004791:Enzyme Inhibitors; D005960:Glucosides; D065089:Glycoside Hydrolase Inhibitors; D017705:Lignans; D010936:Plant Extracts; D055292:Pancreatic alpha-Amylases; D000520:alpha-Glucosidases; C060283:secoisolariciresinol