title: The trichodysplasia spinulosa-associated polyomavirus: virological background and clinical implications.
abstract: Trichodysplasia spinulosa-associated polyomavirus (TSPyV) is a new species of the family Polyomaviridae that was discovered in 2010. TSPyV infects humans and is associated with the development of a rare disease called trichodysplasia spinulosa. Trichodysplasia spinulosa is a skin disease of severely immunocompromised hosts characterized by follicular distention and keratotic spine formation especially on the face. Electron microscopy, immunohistochemistry, and viral load measurements indicate an etiological role of active TSPyV infection in the development of this disease. This review will address virological and pathogenic properties of TSPyV, as well as epidemiologic, diagnostic, and therapeutic aspects of TSPyV infection.
authors.affiliation: Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
authors.forename: Siamaque
authors.initials: S
authors.lastname: Kazem
authors.forename: Els
authors.initials: E
authors.lastname: van der Meijden
authors.forename: Mariet C W
authors.initials: MC
authors.lastname: Feltkamp
mesh_terms: D004279:DNA, Viral / Q000302:isolation & purification; D006201:Hair Diseases / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D016867:Immunocompromised Host; D007642:Keratosis / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D008854:Microscopy, Electron; D011120:Polyomavirus / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D027601:Polyomavirus Infections / Q000150:complications* / Q000188:drug therapy / Q000635:transmission; D011537:Pruritus / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D016036:Seroepidemiologic Studies
chemical_list: D004279:DNA, Viral
keywords: Polyomavirus; Trichodysplasia spinulosa; Trichodysplasia spinulosa-associated polyomavirus; infection; skin