title: Attenuation of gouty arthritis by emodinol in monosodium urate crystal-treated mice.
abstract: A series of studies have recently demonstrated that the release of interleukin 1β induced by monosodium urate crystals is central to the experimental gouty arthritis. Elaeagnus pungens has been traditionally used for the treatment of gouty arthritis in China for more than thousands years. However, there is still little known about the active ingredients and mechanisms of E. pungens against gouty arthritis. Emodinol, as a major triterpene compound in E. pungens, has been seldom reported to have an effect on gouty arthritis. Therefore, the potential beneficial effects and mechanisms of emodinol on gouty arthritis were investigated in this study. Results showed that it significantly ameliorated the hyperalgesia, inflammation, and levels of multiple proinflammatory cytokines in monosodium urate crystals-treated mice. These findings elucidate that emodinol exhibits a prominent effect on improving symptoms of acute gouty arthritis induced by monosodium urate crystals through inhibiting the generation of proinflammatory cytokines.
authors.affiliation: School of Pharmacy, South-Central University for Nationalities, Wuhan, PR China. clyhappy05@163.com
authors.forename: Lvyi
authors.initials: L
authors.lastname: Chen
authors.forename: Zhou
authors.initials: Z
authors.lastname: Lan
authors.forename: Shuwei
authors.initials: S
authors.lastname: Ma
authors.forename: Ling
authors.initials: L
authors.lastname: Zhao
authors.forename: Xinzhou
authors.initials: X
authors.lastname: Yang
mesh_terms: D000818:Animals; D015210:Arthritis, Gouty / Q000139:chemically induced / Q000188:drug therapy*; D031263:Elaeagnaceae / Q000737:chemistry; D004797:Enzyme-Linked Immunosorbent Assay; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014527:Uric Acid / Q000008:administration & dosage*
chemical_list: C478118:1beta, 3beta, 23-trihydroxyolean-12-en-28-oic acid; D053583:Interleukin-1beta; D015850:Interleukin-6; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D014527:Uric Acid; D009828:Oleanolic Acid