title: [A case of double primary neuroendocrine tumor from duodenum and pancreas].
abstract: Gastrointestinal neuroendocrine tumors arise from cells of the diffuse neuroendocrine system and can take place almost anywhere within the gastrointestinal tract. A 40-year-old man admitted to evaluate a duodenal subepithelial lesion which was incidentally found at health check-up. The polypoid duodenal subepithelial lesion, measuring about 7 mm, was removed by the endoscopic mucosal resection and the pathology confirmed a neuroendocrine tumor. Abdominopelvic computed tomography, done for staging work up, revealed a mass in the pancreatic head and the patient received pylorus preserving pancreaticoduodenectomy. Mass at the pancreas also found out to be neuroendocrine tumor but showed different histopathologic traits under immunohistochemical staining. The patient was also diagnosed as hyperparathyroidism and pituitary microadenoma. Finally, multiple endocrine neoplasia type 1 was confirmed, which was accompanied by duodenal neuroendocrine tumor.
authors.affiliation: Departments of Internal Medicine, Pathology and Surgery,Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Dae Won
authors.initials: DW
authors.lastname: Ma
authors.forename: Min Kyung
authors.initials: MK
authors.lastname: Kim
authors.forename: Sun Och
authors.initials: SO
authors.lastname: Yoon
authors.forename: Kwangwon
authors.initials: K
authors.lastname: Rhee
authors.forename: Dong Sup
authors.initials: DS
authors.lastname: Yoon
authors.forename: Hyojin
authors.initials: H
authors.lastname: Park
mesh_terms: D000328:Adult; D019002:CD56 Antigen / Q000378:metabolism; D004386:Duodenum / Q000473:pathology*; D016145:Endoscopy, Digestive System; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009378:Neoplasms, Multiple Primary; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D010179:Pancreas / Q000473:pathology*; D016708:Synaptophysin / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D019002:CD56 Antigen; D016708:Synaptophysin