title: [Peritoneal dialysis from the beginnings up to today: which developments of the last decades were important?].
abstract: During the past years new developments in peritoneal dialysis (PD) technique have resulted in continuous improvement of patient outcome. The importance of salt and fluid balance, residual renal function and peritoneal glucose load are of increasing interest, whereas small solute clearances have lost importance. In patients with high peritoneal transport rates automated PD (APD) is indicated. However, APD can also be chosen as initial PD treatment since recent studies show comparable or even better survival as compared to continuous ambulatory PD patients. Alternative PD solutions improve peritoneal ultrafiltration (icodextrin), reduce peritoneal glucose load (amino acid solution, icodextrin) and protect the peritoneal membrane (solutions with low concentration of glucose degradation products). Infection risk can be reduced when using antibiotic creams, but resistances should be considered. Ongoing studies will clarify if non-antibiotic agents, e.g. medihoney, are effective in preventing PD-associated infections. Due to these improvements PD and hemodialysis have become equivalent treatments.
authors.affiliation: Abteilung für Nephrologie und Dialyse, Klinik für Innere Medizin III, Medizinische Universität Wien, Wien, Österreich. andreas.vychytil@meduniwien.ac.at
authors.forename: Andreas
authors.initials: A
authors.lastname: Vychytil
mesh_terms: D001317:Austria; D015314:Dialysis Solutions / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007676:Kidney Failure, Chronic / Q000266:history* / Q000628:therapy; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000266:history* / Q000639:trends*; D011379:Prognosis; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D015314:Dialysis Solutions