title: A palladium-catalyzed coupling of 3-chloroquinoxalinones with various nitrogen-containing nucleophiles.
abstract: An efficient and general palladium-catalyzed coupling of 3-chloro-quinoxalinones with a variety of nitrogen-containing nucleophiles such as (hetero)aromatic and aliphatic amides as well as some challenging weakly nucleophilic nitrogen compounds including lactams, carbamates and NH-containing azoles is described. In all cases, the reactions take place rapidly and cleanly in dioxane using Pd(OAc)2 as a catalyst, Xantphos as a ligand and K2CO3 as a base furnishing the coupling 3-N-substituted quinoxalinone products in good to excellent yields.
authors.affiliation: Université Paris-Sud, CNRS, BioCIS UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, F-92296, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Brachet
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Peyrat
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Brion
authors.forename: Samir
authors.initials: S
authors.lastname: Messaoudi
authors.forename: Mouâd
authors.initials: M
authors.lastname: Alami
mesh_terms: D002384:Catalysis; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011810:Quinoxalines / Q000737:chemistry*
chemical_list: D011810:Quinoxalines; D010165:Palladium; D009584:Nitrogen