title: Natural antibodies to nucleic acids.
abstract: Blood of healthy donors contains low concentrations of autoantibodies to its own components, including DNA and RNA. Increased concentrations of antibodies to DNA and RNA have been found in blood of people and animals with autoimmune diseases and viral and bacterial infections. Detection of different antibodies with catalytic activities, including abzymes with DNase and RNase activities, is the earliest indicator of the development of some autoimmune diseases. This review reveals possible mechanisms of generation of anti-DNA and anti-RNA antibodies without catalytic activities and abzymes in normal organisms and in organisms with different pathologies. A possible role of these autoantibodies and the reasons of their exceptional diversity in normal organisms and in organisms with different autoimmune diseases are discussed.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, 630090 Novosibirsk, Russia. nevinsky@niboch.nsc.ru
authors.forename: V N
authors.initials: VN
authors.lastname: Buneva
authors.forename: M A
authors.initials: MA
authors.lastname: Krasnorutskii
authors.forename: G A
authors.initials: GA
authors.lastname: Nevinsky
mesh_terms: D000818:Animals; D017151:Antibodies, Catalytic / Q000378:metabolism*; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood; D006801:Humans; D009696:Nucleic Acids / Q000276:immunology* / Q000378:metabolism
chemical_list: D017151:Antibodies, Catalytic; D001323:Autoantibodies; D009696:Nucleic Acids