title: ABA and ABC renewal of conditioned magazine approach are not impaired by dorsal hippocampus inactivation or lesions.
abstract: Three experiments investigated the role of the dorsal hippocampus (DH) in renewal of conditioned and then extinguished magazine approach responding in rats. Experiments 1 and 2 found no effect of muscimol inactivation of the DH during testing on ABA and ABC renewal, respectively. However, subjects from these studies were subsequently found to be impaired on a delayed non-matching-to-place task following muscimol but not saline infusions. Experiment 3 found no effects of post-training excitotoxic lesions of the DH on ABA and ABC renewal. Lesioned subjects were, however, impaired on the delayed non-matching-to-place task compared to control subjects. These findings suggest that the DH may not play a similar role in Pavlovian extinction in appetitive learning tasks as has previously been reported in aversive learning.
authors.affiliation: Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA. vc42@nyu.edu
authors.forename: Vincent
authors.initials: V
authors.lastname: Campese
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Delamater
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001930:Brain Injuries / Q000503:physiopathology*; D003214:Conditioning, Classical / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects* / Q000502:physiology; D005239:Fear / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D007858:Learning / Q000187:drug effects; D009118:Muscimol / Q000494:pharmacology*; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D009118:Muscimol