title: Different levels of cortical excitability reflect clinical fluctuations in migraine.
abstract: BACKGROUND
  In a previous study we demonstrated that high-frequency oscillations (HFOs) elicited by median nerve stimulation are significantly correlated to clinical fluctuations of migraine. We aimed at verifying whether clinical fluctuations and HFO changes are correlated to N20 somatosensory evoked potential (SEP) recovery cycle, which is likely to reflect the functional refractoriness of primary somatosensory cortex neurons.
  
  
  METHODS
  We analysed both HFOs and N20 SEP recovery cycle to paired stimulation in 21 migraine patients and 18 healthy volunteers.
  
  
  RESULTS
  Shortened recovery cycle correlated with low-amplitude HFOs as well as with clinical worsening. By contrast, prolonged recovery cycle correlated with enhanced HFOs, as well as with spontaneous clinical improvement.
  
  
  CONCLUSIONS
  In our migraine patients the strict relationship between presynaptic HFO amplitude and N20 recovery function suggests that changes of both parameters might be caused by modifications of the thalamo-cortical drive. Our findings suggest that the thalamo-cortical drive during interictal stages could fluctuate from abnormally high to abnormally low levels, depending on mechanisms which reduce cortical excitability in spontaneously improving patients, and increase cortical excitability in spontaneously worsening ones.
authors.affiliation: Department of Neurosciences, Catholic University, Italy. drestuccia@rm.unicatt.it
authors.forename: Domenico
authors.initials: D
authors.lastname: Restuccia
authors.forename: Catello
authors.initials: C
authors.lastname: Vollono
authors.forename: Ivana
authors.initials: I
authors.lastname: del Piero
authors.forename: Lucia
authors.initials: L
authors.lastname: Martucci
authors.forename: Sergio
authors.initials: S
authors.lastname: Zanini
mesh_terms: D000328:Adult; D019540:Area Under Curve; D002540:Cerebral Cortex / Q000503:physiopathology*; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008881:Migraine Disorders / Q000503:physiopathology*
keywords: Migraine pathogenesis; excitability; high-frequency oscillations; somatosensory evoked potentials; thalamus