title: Serum metabolomics reveals lipid metabolism variation between coronary artery disease and congestive heart failure: a pilot study.
abstract: The aim of this pilot study is to find discriminating signals from the patient's congestive heart failure (HF) caused by coronary artery disease (CAD) through a non-target metabolomics method and test their usefulness in progress of human HF diseases. Multivariate data analysis was used to identify the discriminating signals. Interestingly, 12 metabolites contributing to the complete separation of HF from matched CAD were identified. Metabolic pathways including free fatty acids, sphingolipids and amino acid derivatives were found to be disturbed in HF patients compared with CAD patients. Lipid molecules associated with energy metabolism and signaling pathways may play key roles in the development of failing heart.
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Hemi
authors.initials: H
authors.lastname: Luan
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Chen
authors.forename: Shilong
authors.initials: S
authors.lastname: Zhong
authors.forename: Xune
authors.initials: X
authors.lastname: Yuan
authors.forename: Nan
authors.initials: N
authors.lastname: Meng
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Fu
authors.forename: Ran
authors.initials: R
authors.lastname: Xu
authors.forename: Connie
authors.initials: C
authors.lastname: Lee
authors.forename: Siyuan
authors.initials: S
authors.lastname: Song
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.forename: Xun
authors.initials: X
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D013058:Mass Spectrometry; D055432:Metabolomics; D008875:Middle Aged
chemical_list: D015415:Biomarkers