title: The effect of daclizumab on brain atrophy in relapsing-remitting multiple sclerosis.
abstract: Daclizumab is a monoclonal antibody that reduces inflammation in multiple sclerosis (MS). Through a retrospective analysis, our objective was to determine whether daclizumab treatment reduces the rate of brain structure atrophy in comparison to a mixture of other disease-modifying therapies (mainly different interferon β preparations). We analyzed MRI examinations (1332 scans from 70 MS cases) obtained between 2000 and 2011 in a single center and processed with an automated brain segmentation method. We used mixed-effects multivariable linear regression models to determine whether a median of 4.3 years of daclizumab therapy in 26 patients altered rates of brain-volume change, controlling for variations in MRI protocol. The control group consisted of 44 patients not treated with daclizumab. We found that supratentorial brain volume declined by 5.17 ml per year (95% confidence limits: 3.58-6.77) off daclizumab therapy. On daclizumab, the annual rate of volume loss decreased to 3.72 ml (p=0.01). The rate of ventricular enlargement decreased from 1.26 to 0.42 ml per year (p<0.001). Focused analysis suggests that reduction in gray matter atrophy rate most likely underlies these results. In summary, in this retrospective analysis, daclizumab therapy substantially decreased the rate of brain atrophy in relapsing-remitting MS in comparison to other disease-modifying therapies, predominantly interferon β.
authors.affiliation: National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA.
authors.forename: Isabela T
authors.initials: IT
authors.lastname: Borges
authors.forename: Colin D
authors.initials: CD
authors.lastname: Shea
authors.forename: Joan
authors.initials: J
authors.lastname: Ohayon
authors.forename: Blake C
authors.initials: BC
authors.lastname: Jones
authors.forename: Roger D
authors.initials: RD
authors.lastname: Stone
authors.forename: John
authors.initials: J
authors.lastname: Ostuni
authors.forename: Navid
authors.initials: N
authors.lastname: Shiee
authors.forename: Henry
authors.initials: H
authors.lastname: McFarland
authors.forename: Bibiana
authors.initials: B
authors.lastname: Bielekova
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Reich
keywords: Brain atrophy; Brain volume; Daclizumab; Gray matter; Interferon beta; Multiple sclerosis