title: [Changes in synovial fluid in different knee-joint diseases].
abstract: OBJECTIVE
  To analyse the changes in synovial fluid (SF) in the most common knees joint diseases, and to establish a relationship according to its concentration.
  
  
  METHODS
  A total of 62 synovial fluids were analysed from knees with, meniscus disease (32), anterior cruciate ligament (ACL) (17) and isolated chondral injury (13). A quantitative and quality study was performed on each sample, which included cytokines IL-1, IL-2, IL-6, IL-10, TNF-α, and growth factors, IGF-1 and TGF-ß).
  
  
  RESULTS
  The SF environment in the ACL injury was mainly anabolic and inflammatory, with increased levels of IL1, IL6, significant levels of TGF-ß (P=.02 and P=.004), IL-10 (P=.046 and P=.047) and significantly decreased levels of TNF-α (P=.02 and P=.004). There was mainly a catabolic environment in chondral and meniscal disease, with a significant increase in TNF-α and a significant decrease in TGF-ß (P=.02 and P=.004). The differences were greater in the case of isolated chondral injury.
  
  
  CONCLUSIONS
  The changes observed show that, as well as the biomechanical changes, the SF has a negative effect on joint homeostasis, it composition varying depending on the type of pathology.
authors.affiliation: Servicio de Cirugía Ortopédica y Traumatología, Hospital de Torrejón, Madrid, España.
authors.forename: P
authors.initials: P
authors.lastname: Martínez de Albornoz Torrente
authors.forename: F
authors.initials: F
authors.lastname: Forriol
mesh_terms: D000328:Adult; D016207:Cytokines / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis / Q000096:biosynthesis*; D007592:Joint Diseases / Q000378:metabolism*; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D013582:Synovial Fluid / Q000737:chemistry / Q000378:metabolism*; D055815:Young Adult
chemical_list: D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins