title: STAT activation in malignancies: roles in tumor progression and in the generation of antineoplastic effects of IFNs.
abstract: As signal transducers and transcription factors, signal transducer and activator of transcriptions (STATs) exert a critical role in cell growth, differentiation, and cell death. Their dysregulation that may lead to constitutive activation, no activation, or functional change, is associated with many different cancers. In this review, the contribution of STATs to cancer growth and progression is presented, and then the context in which interferon regulation of STAT activation provides a mechanism for therapeutic intervention for specific cancers is discussed.
authors.affiliation: Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
authors.forename: Ben X
authors.initials: BX
authors.lastname: Wang
authors.forename: Leonidas C
authors.initials: LC
authors.lastname: Platanias
authors.forename: Eleanor N
authors.initials: EN
authors.lastname: Fish
mesh_terms: D017209:Apoptosis; D002454:Cell Differentiation; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D004789:Enzyme Activation; D006801:Humans; D007372:Interferons / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D050791:STAT Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D050791:STAT Transcription Factors; D007372:Interferons