title: Chemical constituents from the leaves of Annona reticulata and their inhibitory effects on NO production.
abstract: In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC₅₀ values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM.
authors.affiliation: Department of Chemistry, Vinh University, Vinh 42000, Vietnam.
authors.forename: Tran Dinh
authors.initials: TD
authors.lastname: Thang
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.forename: Guan-Jhong
authors.initials: GJ
authors.lastname: Huang
authors.forename: Nguyen Huy
authors.initials: NH
authors.lastname: Hung
authors.forename: Bow-Shin
authors.initials: BS
authors.lastname: Huang
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Yang
authors.forename: Ngo Xuan
authors.initials: NX
authors.lastname: Luong
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000818:Animals; D031041:Annona / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000009:adverse effects; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D010936:Plant Extracts; D009569:Nitric Oxide