title: Lipoprotein (a) Levels in Relation to Severity of Coronary Artery Disease in North Indian Patients.
abstract: BACKGROUND
  Lipoprotein (a) [Lp (a)] is an established risk marker of coronary artery disease which is independent from other risk factors.
  
  
  OBJECTIVE
  The aim was to address the association between Lp (a) and CAD risk in North Indians. To evaluate whether high levels of lipoprotein (a) [Lp (a)] is a predictor of risk and is related to the severity of CAD.
  
  
  METHODS
  This was a cross-sectional study done on 360 patients presenting with chest pain. Coronary angiography revealed CAD in 270 patients and 90 patients without CAD. Lipoprotein (a) level, lipid profile, fasting blood glucose, anthropometric and clinical parameters were analyzed.
  
  
  RESULTS
  Lipoprotein (a) 21.0 mg/dL is associated with the presence of coronary lesions (P = 0.0001). A highly significant difference in Lp (a) levels was observed between normal coronaries vs. single-vessel disease, double-and triple-vessel disease ( P < 0.0001). Body mass index (BMI) was significantly raised in CAD group compared to normal coronary.
  
  
  CONCLUSIONS
  Multivariate analysis found that Lp (a) was considered an independent predictor for severity of CAD and Lp (a) levels 21.0 mg/dL are associated with severe patterns of coronary atherosclerosis.
authors.affiliation: Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
authors.forename: Fauzia
authors.initials: F
authors.lastname: Ashfaq
authors.forename: Pravin Kumar
authors.initials: PK
authors.lastname: Goel
authors.forename: Rishi
authors.initials: R
authors.lastname: Sethi
authors.forename: Mohd Idrees
authors.initials: MI
authors.lastname: Khan
authors.forename: Wahid
authors.initials: W
authors.lastname: Ali
authors.forename: Mohd Zafar
authors.initials: MZ
authors.lastname: Idris
keywords: Angiography; atherosclerosis; lipoprotein (a); triglyceride