title: Colorectal cancer: looking for answers in the microbiota.
abstract: At a simplistic level, colorectal cancer arises from mutations in various proto-oncogenes and tumor suppressor genes. Aside from genetically inherited factors, environmental, lifestyle, and dietary habits have all been identified as risk agents promoting mutational events leading to the development of colorectal cancer. This "In Focus" presents evidence that the intestinal endogenous bacterial community represents a risk factor for the development of colorectal cancer.
authors.affiliation: Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA. job@med.unc.edu
authors.forename: Christian
authors.initials: C
authors.lastname: Jobin
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000382:microbiology*; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D054892:Metagenome; D051192:Receptors, Pattern Recognition / Q000378:metabolism
chemical_list: D051192:Receptors, Pattern Recognition