title: If the wheel ain't broke, don't reinvent it.
abstract: During the past 100 years, several theories explaining human atherosclerosis have been postulated and tested. More than anything else, experimental and observational evidence has supported a very strong causal role for dyslipidemia. This has been established as the current paradigm in both biomedical research as well as public health policies. Recently, a novel hypothesis for the etiology of atherosclerosis was presented. The purpose of this commentary is to critically evaluate its validity.
authors.forename: Pauli
authors.initials: P
authors.lastname: Ohukainen
mesh_terms: D050197:Atherosclerosis / Q000209:etiology* / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D008798:Mevalonic Acid / Q000378:metabolism*; D008955:Models, Cardiovascular
chemical_list: D002784:Cholesterol; D008798:Mevalonic Acid