title: β-Arylation of carboxamides via iron-catalyzed C(sp3)-H bond activation.
abstract: A 2,2-disubstituted propionamide bearing an 8-aminoquinolinyl group as the amide moiety can be arylated at the β-methyl position with an organozinc reagent in the presence of an organic oxidant, a catalytic amount of an iron salt, and a biphosphine ligand at 50 °C. Various features of selectivity and reactivity suggest the formation of an organometallic intermediate via rate-determining C-H bond cleavage rather than a free-radical-type reaction pathway.
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Rui
authors.initials: R
authors.lastname: Shang
authors.forename: Laurean
authors.initials: L
authors.lastname: Ilies
authors.forename: Arimasa
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nakamura