title: Spir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice.
abstract: BACKGROUND
  Streptococcus pneumoniae causes over one million deaths worldwide annually, despite recent developments in vaccine and antibiotic therapy. Host susceptibility to pneumococcal infection and disease is controlled by a combination of genetic and environmental influences, but current knowledge remains limited.
  
  
  RESULTS
  In order to identify novel host genetic variants as predictive risk factors or as potential targets for prophylaxis, we have looked for quantitative trait loci in a mouse model of invasive pneumococcal disease. We describe a novel locus, called Streptococcus pneumoniae infection resistance 2 (Spir2) on Chr4, which influences time to morbidity and the development of bacteraemia post-infection.
  
  
  CONCLUSIONS
  The two quantitative trait loci we have identified (Spir1 and Spir2) are linked significantly to both bacteraemia and survival time. This may mean that the principle cause of death, in our model of pneumonia, is bacteraemia and the downstream inflammatory effects it precipitates in the host.
authors.affiliation: MRC Mammalian Genetics Unit, Harwell, Oxon OX11 0RD, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Wisby
authors.forename: Vitor E
authors.initials: VE
authors.lastname: Fernandes
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Neill
authors.forename: Aras
authors.initials: A
authors.lastname: Kadioglu
authors.forename: Peter W
authors.initials: PW
authors.lastname: Andrew
authors.forename: Paul
authors.initials: P
authors.lastname: Denny
mesh_terms: D000818:Animals; D016470:Bacteremia / Q000235:genetics / Q000382:microbiology; D001947:Breeding; D033481:Chromosomes, Mammalian; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D008126:Lod Score; D008297:Male; D051379:Mice; D008840:Microfilament Proteins / Q000235:genetics*; D010641:Phenotype; D011008:Pneumococcal Infections / Q000235:genetics* / Q000382:microbiology / Q000401:mortality; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D013296:Streptococcus pneumoniae
chemical_list: D008840:Microfilament Proteins; C556674:Spir-2 protein, mouse