title: Resting-state magnetoencephalography study of "small world" characteristics and cognitive dysfunction in patients with glioma.
abstract: BACKGROUND
  The purpose of this study was to analyze "small world" characteristics in glioma patients in order to understand the relationship between cognitive dysfunction and brain functional connectivity network in the resting state.
  
  
  METHODS
  Resting-state magnetoencephalography was performed in 20 patients with glioma and 20 healthy subjects. The clustering coefficient of the resting functional connectivity network in the brain, average path length, and "small world" index (SWI) were calculated. Cognitive function was estimated by testing of attention, verbal fluency, memory, athletic ability, visual-spatial ability, and intelligence.
  
  
  RESULTS
  Compared with healthy controls, patients with glioma showed decreased cognitive function, and diminished low and high gamma band "small world" characteristics in the resting functional connectivity network.
  
  
  CONCLUSIONS
  The SWI is associated with cognitive function and is diminished in patients with glioma, and is therefore correlated with cognition dysfunction.
authors.affiliation: Department of Neurosurgery, Brain Hospital Affiliated to Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Hu
authors.forename: Ting
authors.initials: T
authors.lastname: Lei
authors.forename: Hua-Zhong
authors.initials: HZ
authors.lastname: Xu
authors.forename: Yuan-Jie
authors.initials: YJ
authors.lastname: Zou
authors.forename: Hong-Yi
authors.initials: HY
authors.lastname: Liu
keywords: cognitive dysfunction; functional connectivity network; glioma; magnetoencephalography; “small world”