title: Near full-length genomic characterization of a novel HIV type 1 CRF07_ BC/01_AE recombinant in men who have sex with men from Sichuan, China.
abstract: In recent years, the men who have sex with men (MSM) population has seen the fastest growing prevalence of HIV transmission in China. In addition, coinfection through sex and intravenous drug use is a major problem in HIV prevention and control. Recent studies have also revealed that three major viral strains (CRF07_BC, CRF01_AE, and subtype B) have been cocirculating among MSM in Sichuan, suggesting a high probability of generating new recombinants. This study reports a near full-length genome of a novel HIV-1 recombinant (MSM0720) between CRF07_BC and CRF01_AE. The analysis of MSM0720 shows that the genome is composed of at least 11 interlaced segments, including six CRF07_BC and five CRF01_AE segments, with CRF07_BC as the backbone; this is different from a previously identified CRF01_AE/07_BC recombinant strain in intravenous drug users from Jiangsu.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Huamian
authors.initials: H
authors.lastname: Wei
authors.forename: Ling
authors.initials: L
authors.lastname: Su
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Xiang
authors.initials: X
authors.lastname: He
authors.forename: Jenny
authors.initials: J
authors.lastname: His
authors.forename: Shu
authors.initials: S
authors.lastname: Liang
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
mesh_terms: D002681:China / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology* / Q000235:genetics; D006679:HIV Seropositivity / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D015995:Prevalence; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D012725:Sexual Behavior