title: Comparison of azithromycin and clarithromycin triple therapy regimens for helicobacter pylori eradication in hemodialysis patients.
abstract: BACKGROUND
  Helicobacter pylori eradication with clarithromycin is more expensive than with azithromycin.
  
  
  OBJECTIVE
  This study aimed to compare the effectiveness of these two antibiotics in eradicating H. pylori in hemodialysis (HD) patients.
  
  
  METHODS
  This is a prospective, randomized, double-blinded clinical trial analysis of HD patients. Patients who had dyspepsia and showed positive results for two of three tests, anti-H. pylori serology, H. pylori stool antigen (HpSAg), or Urease Breath Test (UBT), were included in the study. The subjects consisted of 39 dialysis patients who were randomly divided into two groups that received medication twice daily. Group OAC received 20 mg omeprazol, 500 mg amoxycilin, and 250 mg clarithromycin, and Group OAAz received 20 mg omeprazol, 500 mg amoxicillin, and 250 mg azithromycin. Both regimens were administered for 14 days. Eradication was investigated by performing the UBT and the HpSAg test eight weeks later.
  
  
  RESULTS
  This study began with 39 patients, 37 of which completed the treatment schedule (20 males and 17 females, mean age 59 years). Two patients died due to MI before beginning treatment. In the OAC group, negative results on the UBT and HpSAg tests were found in 82.4% and 88.2% of the participants, respectively. In the OAAz group, these values were 80% and 85%, respectively. The data showed that the difference between the two regimens was not significant (P = 1.0).
  
  
  CONCLUSIONS
  According to the data, no differences in eradication rates were apparent between the azitromycin and the claritromycin regimens. However, lower cost and fewer complaints could be considered as an advantage of the triple therapy with azithromycin.
authors.affiliation: Departments of Nephrology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Jalalzadeh
authors.forename: Morteza
authors.initials: M
authors.lastname: Nazarian
authors.forename: Jamshid
authors.initials: J
authors.lastname: Vafaeimanesh
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mirzamohammadi
keywords: Azithromycin; Clarithromycin; Helicobacter Pylori