title: Photocrosslinkable biodegradable elastomers based on cinnamate-functionalized polyesters.
abstract: Synthetic biodegradable elastomers are an emerging class of materials that play a critical role in supporting innovations in bioabsorbable medical implants. This paper describes the synthesis and characterization of poly(glycerol-co-sebacate)-cinnamate (PGS-CinA), a biodegradable elastomer based on hyperbranched polyesters derivatized with pendant cinnamate groups. PGS-CinA can be prepared via photodimerization in the absence of photoinitiators using monomers that are found in common foods. The resulting network exhibits a Young's modulus of 50.5-152.1kPa and a projected in vitro degradation half-life time between 90 and 140days. PGS-CinA elastomers are intrinsically cell-adherent and support rapid proliferation of fibroblasts. Spreading and proliferation of fibroblasts are loosely governed by the substrate stiffness within the range of Young's moduli in PGS-CinA networks that were prepared. The thermo-mechanical properties, biodegradability and intrinsic support of cell attachment and proliferation suggest that PGS-CinA networks are broadly applicable for use in next generation bioabsorable materials including temporary medical devices and scaffolds for soft tissue engineering.
authors.affiliation: Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
authors.forename: Congcong
authors.initials: C
authors.lastname: Zhu
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Kustra
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Bettinger
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000528:radiation effects; D001826:Body Fluids / Q000737:chemistry; D002448:Cell Adhesion / Q000502:physiology*; D002934:Cinnamates / Q000737:chemistry* / Q000528:radiation effects; D003432:Cross-Linking Reagents / Q000737:chemistry* / Q000528:radiation effects; D003651:Decanoates / Q000737:chemistry* / Q000528:radiation effects; D055119:Elastic Modulus / Q000528:radiation effects; D020724:Elastomers / Q000737:chemistry* / Q000528:radiation effects; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000528:radiation effects; D008027:Light; D008422:Materials Testing; D051379:Mice; D041681:NIH 3T3 Cells; D011091:Polyesters / Q000737:chemistry / Q000528:radiation effects; D011108:Polymers / Q000737:chemistry* / Q000528:radiation effects
chemical_list: D001672:Biocompatible Materials; D002934:Cinnamates; D003432:Cross-Linking Reagents; D003651:Decanoates; D020724:Elastomers; D011091:Polyesters; D011108:Polymers; C469892:poly(glycerol-sebacate); D005990:Glycerol