title: Nonarteritic anterior ischemic optic neuropathy as the presenting manifestation of primary antiphospholipid syndrome.
abstract: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by vascular thrombosis or pregnancy morbidity. Ocular involvement in APS includes a broad spectrum of manifestations involving anterior and posterior segment or the presence of neuroophthalmologic features. Nonarteritic anterior ischemic optic neuropathy (NAION) is a very rare finding, and in this report a case having NAION as the prevailing sign of APS is presented. A middle-aged women who presented with visual disturbances in her left eye (LE) and turned out to have the diagnosis of primary APS with the help of rheumatological investigations is discussed. She was treated with oral steroids for NAION in her LE. With systemic and rheumatological work-up, primary APS was diagnosed, and hydroxychloroquine, coumadin, and aspirin were started, after which she remained stable under control. Due to the important diagnostic and therapeutic implications of APS, it should be considered in the differential diagnosis of NAION, particularly when the etiology is uncertain.
authors.forename: Betul
authors.initials: B
authors.lastname: Tugcu
authors.affiliation: Department of Ophthalmology, Beyoglu Eye Research and Training Hospital, Istanbul, Turkey.
authors.forename: Nur
authors.initials: N
authors.lastname: Acar
authors.forename: Cigdem Tanriverdi
authors.initials: CT
authors.lastname: Coskun
authors.forename: Selda
authors.initials: S
authors.lastname: Celik
authors.forename: Fadime Ulviye
authors.initials: FU
authors.lastname: Yigit
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D003937:Diagnosis, Differential; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis* / Q000209:etiology; D057972:Posterior Eye Segment / Q000473:pathology*; D014792:Visual Acuity