title: Vasodilatory effect and endothelial integrity in papaverine- and milrinone-treated human radial arteries.
abstract: Prevention of the vasospasm is an important aspect of coronary artery bypass grafting (CABG) with the use of radial artery (RA) as the conduit. We compared the effect of two phosphodiesterase inhibitors papaverine and milrinone on vasodilation and endothelial integrity of human RA segments harvested from 20 CABG patients. Vasodilatory effect of the drugs were assessed by organ bath technique in RA rings precontracted with KCl and phenylephrine. Endothelial integrity was evaluated by CD34 immunofluorescence in frozen sections. Vasorelaxation induced by papaverine was significantly greater as compared to that induced by milrinone (90.47% ± 10.16% vs. 78.98% ± 19.56%, p<0.05). Similarly, pretreament with papaverine more strongly inhibited the contractile response of RA rings to KCl (6.0 ± 8.0 mN vs. 26.7 ± 21.5 mN, p<0.001). Papaverine was also superior to milrinone in the preservation of endothelial integrity (75.3% ± 12.9% vs. 51.8% ± 18.0%, p<0.02). In conclusion, papaverine seems to be more suitable than milrinone for prevention of vasospasm in radial artery conduits used for CABG.
authors.affiliation: Department of Cardiovascular Surgery and Transplantology, John Paul II Hospital, Jagiellonian University Medical College, Cracow, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Rudzinski
authors.forename: P
authors.initials: P
authors.lastname: Wegrzyn
authors.forename: G J
authors.initials: GJ
authors.lastname: Lis
authors.forename: J
authors.initials: J
authors.lastname: Piatek
authors.forename: J
authors.initials: J
authors.lastname: Konstanty-Kalandyk
authors.forename: R
authors.initials: R
authors.lastname: Nosalski
authors.forename: T
authors.initials: T
authors.lastname: Mikolajczyk
authors.forename: M
authors.initials: M
authors.lastname: Jasinska
authors.forename: G
authors.initials: G
authors.lastname: Pyka-Fosciak
authors.forename: T
authors.initials: T
authors.lastname: Guzik
authors.forename: J A
authors.initials: JA
authors.lastname: Litwin
authors.forename: R
authors.initials: R
authors.lastname: Korbut
authors.forename: J
authors.initials: J
authors.lastname: Sadowski
mesh_terms: D001026:Coronary Artery Bypass / Q000379:methods; D003329:Coronary Vasospasm / Q000517:prevention & control; D004730:Endothelium, Vascular / Q000187:drug effects*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D020105:Milrinone / Q000494:pharmacology*; D010208:Papaverine / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D017534:Radial Artery / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D010726:Phosphodiesterase Inhibitors; D014665:Vasodilator Agents; D010208:Papaverine; D020105:Milrinone