title: [Ir(P-OP)]-catalyzed asymmetric hydrogenation of diversely substituted C═N-containing heterocycles.
abstract: Iridium(I) complexes of enantiomerically pure phosphine-phosphite ligands ([Ir(Cl)(cod)(P-OP)]) efficiently catalyze the enantioselective hydrogenation of diverse C═N-containing heterocyclic compounds (benzoxazines, benzoxazinones, benzothiazinones, and quinoxalinones; 25 examples, up to 99% ee). A substrate-to-catalyst ratio as high as 2000:1 was reached.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ) , Av. Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Núñez-Rico
authors.forename: Anton
authors.initials: A
authors.lastname: Vidal-Ferran
mesh_terms: D002384:Catalysis; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry*; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D006574:Heterocyclic Compounds, 2-Ring; D007495:Iridium