title: Efficacy of tigecycline alone and in combination with gentamicin in the treatment of experimental endocarditis due to linezolid-resistant Enterococcus faecium.
abstract: We evaluated the efficacy of tigecycline in a rabbit model of experimental endocarditis caused by a linezolid-resistant clinical strain of Enterococcus faecium. Tigecycline-treated animals had a 2.8-log10-CFU/g reduction in microbial counts in excised vegetations compared with controls. Addition of gentamicin caused a further arithmetical reduction in colony counts. The therapeutic effect was sustained 5 days after completion of treatment, as shown by relapse studies performed in treatment groups.
authors.affiliation: Fourth Department of Internal Medicine, University of Athens, Attikon General Hospital, Athens, Greece. kostis_pontikis@yahoo.gr
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Pontikis
authors.forename: Angelos
authors.initials: A
authors.lastname: Pefanis
authors.forename: Thomas
authors.initials: T
authors.lastname: Tsaganos
authors.forename: Ira-Maria
authors.initials: IM
authors.lastname: Tzepi
authors.forename: Dionyssia-Pinelopi
authors.initials: DP
authors.lastname: Carrer
authors.forename: Helen
authors.initials: H
authors.lastname: Giamarellou
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D016984:Enterococcus faecium / Q000187:drug effects*; D005839:Gentamicins / Q000097:blood / Q000627:therapeutic use*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D023303:Oxazolidinones / Q000494:pharmacology; D011817:Rabbits; D000078304:Tigecycline
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D023303:Oxazolidinones; D000078304:Tigecycline; D008911:Minocycline; D000069349:Linezolid