title: Synthesis and antimicrobial activity of some 2-pyridone nucleosides containing a sulfonamide moiety.
abstract: Glycosylation of 2-pyridonesulfonamide 1a,b with glycosyl/galactosyl bromide gave the corresponding glycosides 2a,b, 3a,b, 6a,b, and 7a,b, respectively. Deacetylation of the resulting glycosides gave the corresponding glycosides 4a,b, 5a,b, 8a,b, and 9a,b, respectively, in good yields. Furthermore, reaction of 2-pyridonesulfonamide 1b with lactosyl bromide gave a mixture the corresponding N, O-lactosides 10 and 11, which were deacetylated to give the corresponding glycosides 12 and 13, respectively. The structures of the new synthesized compounds were characterized by using IR, 1H, 13C NMR spectra, and microanalysis. Selected members of these compounds were screened for antimicrobial activity.
authors.affiliation: Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
authors.forename: Ahmed H
authors.initials: AH
authors.lastname: Moustafa
authors.forename: Hassan A
authors.initials: HA
authors.lastname: El-Sayed
authors.forename: Abd El-Fattah Z
authors.initials: Ael-F
authors.lastname: El-Fattah Z Haikal
authors.forename: Rasha A Abd
authors.initials: RA
authors.lastname: Abd El-Hady
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011728:Pyridones / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D009705:Nucleosides; D011728:Pyridones; D013449:Sulfonamides; C017679:2-hydroxypyridine