title: Calcium phosphate hybrid nanoparticles: self-assembly formation, characterization, and application as an anticancer drug nanocarrier.
abstract: Calcium phosphate hybrid nanoparticles (CaP-HNPs) have been synthesized in aqueous solution through self-assembly by using two oppositely charged polyelectrolytes (poly(diallyldimethylammonium chloride) (PDADMAC) and poly(acrylate sodium) (PAS)) as dual templates. First, the PAS/Ca(2+) and PDADMAC/PO4(3-) complexes form through electrostatic interactions and then two complexes self-assemble into CaP-HNPs after mixing them together. The as-prepared CaP-HNPs exhibit a spherical morphology with a narrow size distribution, good dispersibility, and high colloidal stability in water. The CaP-HNPs are explored as a nanocarrier for the anticancer drug docetaxel (Dtxl). The CaP-HNPs show excellent biocompatibility, high drug-loading capacity, pH-sensitive drug-release behavior, and high anticancer effect after being loaded with Dtxl. Therefore, the as-prepared CaP-HNPs are promising drug nanocarriers for cancer therapy.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Zhao
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Zhu
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Bing-Qiang
authors.initials: BQ
authors.lastname: Lu
authors.forename: Chao
authors.initials: C
authors.lastname: Qi
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Jin
authors.initials: J
authors.lastname: Wu
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002130:Calcium Phosphates / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D064347:Microscopy, Electrochemical, Scanning; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011095:Polyethylenes / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D002130:Calcium Phosphates; D004337:Drug Carriers; D011095:Polyethylenes; D000644:Quaternary Ammonium Compounds; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride; C006903:carbopol 940; C020243:calcium phosphate