title: Implementing the "catch-and-release" concept into a simple method for regioselective cyclodextrin modification.
abstract: Differentiation of specific positions in axial-symmetrical cyclodextrins (CDs), exhibiting a dense display of identical functional groups, is challenging. A novel strategy toward this goal that exploits a solid matrix to display the complementary reagent functionalities sufficiently far from each other to prevent CDs from reacting through more than one site is reported. Using a "catch-and-release" process based on the Staudinger reaction, the utility of this concept to easily produce complex CD functionalization patterns in one pot and without any purification step is demonstrated.
authors.affiliation: Institute of Chemical Research (IIQ), CSIC - Universidad de Sevilla , Américo Vespucio 49, E-41092 Sevilla, Spain.
authors.forename: Iris
authors.initials: I
authors.lastname: Pflueger
authors.forename: Juan M
authors.initials: JM
authors.lastname: Benito
mesh_terms: D001386:Azides / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001386:Azides; D003505:Cyclodextrins; D007202:Indicators and Reagents; D010720:Phosphines