title: Elevation of morning blood pressure in sodium resistant subjects by high sodium diet.
abstract: The present study evaluated the response of blood pressure (BP) by dietary sodium in sodium resistant (SR) subjects. One hundred one subjects (mean age, 46.0 yr; 31 hypertensives) were admitted and given low sodium-dietary approaches to stop hypertension (DASH) diet (LSD, 100 mM NaCl/day) for 7 days and high sodium-DASH diet (HSD, 300 mM NaCl/day) for the following 7 days. On the last day of each diet, 24 hr ambulatory BP was measured. Morning systolic BP (SBP) and diastolic BP (DBP) were elevated after HSD in all subjects (P < 0.01), but daytime SBP and DBP were not changed (P > 0.05). In hypertensive subjects, morning DBP elevation was greater than daytime DBP elevation (P = 0.036), although both DBPs were significantly elevated after HSD. The augmented elevation of morning DBP in hypertensive subjects was contributed by the absolute elevation of morning DBP (P = 0.032) and relative elevation to daytime DBP (P = 0.005) in sodium resistant (SR) subjects, but not by sodium sensitive subjects. Although there was no absolute elevation, SR subjects with normotension showed a relative elevation of morning SBP compared to daytime SBP change after HSD (P = 0.009). The present study demonstrates an absolute and relative elevation of morning BP in SR subjects by HSD.
authors.affiliation: Cardiovascular Center, Dongguk University Ilsan Hospital, Goyang, Korea. mooyong_rhee@dumc.or.kr
authors.forename: Moo-Yong
authors.initials: MY
authors.lastname: Rhee
authors.forename: Chi-Yeon
authors.initials: CY
authors.lastname: Lim
authors.forename: Sung-Joon
authors.initials: SJ
authors.lastname: Shin
authors.forename: Sang-Woo
authors.initials: SW
authors.lastname: Oh
authors.forename: Yong-Soon
authors.initials: YS
authors.lastname: Park
authors.forename: Jong-Wook
authors.initials: JW
authors.lastname: Kim
authors.forename: Hye-Kyoung
authors.initials: HK
authors.lastname: Park
authors.forename: Cho-Il
authors.initials: CI
authors.lastname: Kim
authors.forename: Cheol-Young
authors.initials: CY
authors.lastname: Park
authors.forename: Sun-Woong
authors.initials: SW
authors.lastname: Kim
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004039:Diet, Sodium-Restricted; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008875:Middle Aged; D012982:Sodium, Dietary / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D012982:Sodium, Dietary
keywords: Hypertension; Sodium; Sodium Resistance