title: If microbial ecosystem therapy can change your life, what's the problem?
abstract: The increased incidence of morbidity and mortality due to Clostridium difficile infection, had led to the emergence of fecal microbial transplantation (FMT) as a highly successful treatment. From this, a 32 strain stool substitute has been derived, and successfully tested in a pilot human study. These approaches could revolutionize not only medical care of infectious diseases, but potentially many other conditions linked to the human microbiome. But a second revolution may be needed in order for regulatory agencies, society and medical practitioners to accept and utilize these interventions, monitor their long term effects, have a degree of control over their use, or at a minimum provide guidelines for donors and recipients.
authors.affiliation: Human Microbiology and Probiotics, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada.
authors.forename: Grace
authors.initials: G
authors.lastname: Ettinger
authors.forename: Jeremy P
authors.initials: JP
authors.lastname: Burton
authors.forename: Gregor
authors.initials: G
authors.lastname: Reid
mesh_terms: D000285:Administration, Rectal; D000818:Animals; D024881:Drug Resistance, Bacterial; D004761:Enterocolitis, Pseudomembranous / Q000628:therapy*; D005243:Feces / Q000382:microbiology*; D006801:Humans; D054892:Metagenome; D010067:Ownership; D019936:Probiotics / Q000008:administration & dosage