title: Hepatoprotective activity of Musa paradisiaca on experimental animal models.
abstract: OBJECTIVE
  To investigate the hepatoprotective activity of stem of Musa paradisiaca (M. paradisiaca) in CCl4 and paracetamol induced hepatotoxicity models in rats.
  
  
  METHODS
  Hepatoprotective activity of alcoholic and aqueous extracts of stem of M. paradisiaca was demonstrated by using two experimentally induced hepatotoxicity models.
  
  
  RESULTS
  Administration of hepatotoxins (CCl4 and paracetamol) showed significant biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with alcoholic extract (500 mg/kg), more significantly and to a lesser extent the alcoholic extract (250 mg/kg) and aqueous extract (500 mg/kg), reduced the elevated levels of the serum enzymes like serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP) and bilirubin levels and alcoholic and aqueous extracts reversed the hepatic damage towards the normal, which further evidenced the hepatoprotective activity of stem of M. paradisiaca.
  
  
  CONCLUSIONS
  The alcoholic extract at doses of 250 and 500 mg/kg, p.o. and aqueous extract at a dose of 500 mg/kg, p.o. of stem of M. paradisiaca have significant effect on the liver of CCl4 and paracetamol induced hepatotoxicity animal models.
authors.affiliation: Department of Pharmacognosy, PES College of Pharmacy, Bengaluru-560050.
authors.forename: M
authors.initials: M
authors.lastname: Nirmala
authors.forename: K
authors.initials: K
authors.lastname: Girija
authors.forename: K
authors.initials: K
authors.lastname: Lakshman
authors.forename: T
authors.initials: T
authors.lastname: Divya
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004195:Disease Models, Animal; D005765:Gastrointestinal Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D008111:Liver Function Tests; D023421:Models, Animal; D028521:Musa / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D018547:Plant Stems / Q000737:chemistry; D017208:Rats, Wistar; D044967:Serum / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D010936:Plant Extracts; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin
keywords: ALP; Direct bilirubin; Histopathology; Musa paradisiaca; SGOT; SGPT; Total bilirubin