title: A randomized controlled trial of fallopian tube sperm perfusion compared with standard intrauterine insemination for women with non-tubal infertility.
abstract: OBJECTIVE
  Does fallopian tube sperm perfusion (FSP) result in better pregnancy and live birth rates than standard intrauterine insemination (SIUI) for couples with non-tubal infertility with or without gonadotrophin or clomiphene stimulation?
  
  
  CONCLUSIONS
  There was no evidence of an improvement in live birth rates with FSP compared with SIUI.
  
  
  BACKGROUND
  Previous randomized controlled trials have suggested improved live birth rates with FSP but these trials were small. A systematic review published in 2004 suggested heterogeneity in results.
  
  
  METHODS
  This pragmatic, multicentre, randomized controlled trial compared SIUI and FSP in 417 women with non-tubal infertility.
  
  
  METHODS
  The patients were treated at fertility clinics in New Zealand, Australia and the United Arab Emirates.
  
  
  RESULTS
  Four hundred and seventeen women were randomized to SIUI (n = 210) or FSP (n = 207). Data were available for analysis from 198 women in the SIUI group and 198 women in the FSP group. There were 19 women with incomplete data because of cycle cancellation or withdrawals and 2 women who conceived prior to commencing treatment. There were no significant differences in live birth rates between the two groups with 27 (12.9%) in the SIUI group and 21 in the FSP group (10.1%) [Odds Ratio (OR) 1.31 (0.71, 2.39), P = 0.48]. Two ectopic pregnancies were reported in the SIUI group and one was reported in the FSP group.
  
  
  CONCLUSIONS
  Different ovulation protocols were used in the different clinics. Approximately 10% of the cycles involved donor sperm and ∼5% of the cycles did not complete the assigned intervention.
  
  
  CONCLUSIONS
  There was no evidence of an improvement in live birth rates with FSP compared with SIUI.
  
  
  BACKGROUND
  The study was funded in part by the A+ trust of the Auckland District Health Board. No commercial funding was received.
  
  
  BACKGROUND
  ANZCTR Number ACTRN12612001303831.
authors.affiliation: The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. c.farquhar@auckland.ac.nz
authors.forename: C M
authors.initials: CM
authors.lastname: Farquhar
authors.forename: J
authors.initials: J
authors.lastname: Brown
authors.forename: N
authors.initials: N
authors.lastname: Arroll
authors.forename: D
authors.initials: D
authors.lastname: Gupta
authors.forename: C V
authors.initials: CV
authors.lastname: Boothroyd
authors.forename: Maha
authors.initials: M
authors.lastname: Al Bassam
authors.forename: J
authors.initials: J
authors.lastname: Moir
authors.forename: N P
authors.initials: NP
authors.lastname: Johnson
mesh_terms: D000328:Adult; D001723:Birth Rate; D005187:Fallopian Tubes / Q000502:physiology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D010062:Ovulation Induction; D011247:Pregnancy; D013094:Spermatozoa; D016896:Treatment Outcome
keywords: fallopian tube sperm perfusion; intrauterine insemination; randomized controlled trial