title: [Elaboration of the SPM template for the standardization of SPECT images with 123I-Ioflupane].
abstract: OBJECTIVE
  Statistical parametric mapping (SPM) is a widely used produced for normalization of functional images. This study has aimed to develop a normalization template of (123)I-Ioflupane SPECT-imaging DaTSCAN(®), GE Healthcare), not available in SPM5, and to validate it compared to other quantification methods.
  
  
  METHODS
  In order to write the template we retrospectively selected 26 subjects who had no evidence of nigrostriatal degeneration and whose age distribution was similar to that of the patients in the usual practice of our Department: 2 subjects (7.6%) were < 35 years, 9 between 35-65 years (34.6%) and 15 > 65 years (57.7%). All the studies were normalized with the T1-template available in SPM5 and an average image of the value was obtained for each voxel. For validation we analyzed 60 patients: 30 with idiopathic Parkinson's disease patients (iPD) with right involvement (66.83±12.20 years) and 30 with essential tremor patients (ET) (67.27±8.33 years). Specific uptake rates (SUR) of different striatal regions were compared after image normalization with our template and the application of a semiautomated VOIs-map created with Analyze v9.0 ((©)BIR, Mayo Clinic), against two quantification methods: a) manual adjustment of a ROIs-map drawn in Analyze, and b) semi-automated method (HERMES-BRASS) with normalization and implementation of VOIs-map.
  
  
  RESULTS
  No statistically significant differences in the iPD/ET discriminatory capacity between the three methods analyzed were observed (p<0,001). The correlation of SUR after normalization with our «template» was higher than that obtained by method b) (R>0,871, p<0,001). This difference was greater in patients with PD.
  
  
  CONCLUSIONS
  Our study demonstrates the efficacy of our SPM «template» for (123)I-Ioflupane SPECT-imaging, obtained from normalization with «T1-template».
authors.affiliation: Servicio de Medicina Nuclear, UDIM, Hospital Universitario Virgen del Rocío, Sevilla, España. Electronic address: javier191185@gmail.com.
authors.forename: F J
authors.initials: FJ
authors.lastname: García-Gómez
authors.forename: D
authors.initials: D
authors.lastname: García-Solís
authors.forename: F J
authors.initials: FJ
authors.lastname: Luis-Simón
authors.forename: V A
authors.initials: VA
authors.lastname: Marín-Oyaga
authors.forename: F
authors.initials: F
authors.lastname: Carrillo
authors.forename: P
authors.initials: P
authors.lastname: Mir
authors.forename: R J
authors.initials: RJ
authors.lastname: Vázquez-Albertino
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping; D020329:Essential Tremor / Q000000981:diagnostic imaging*; D006801:Humans; D008875:Middle Aged; D009662:Nortropanes; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon / Q000592:standards*
chemical_list: D009662:Nortropanes; C519528:ioflupane
keywords: Dopamina; Dopamine; Dopamine transporters; Enfermedad de Parkinson; Mapas estadísticos paramétricos; Movement disorders; Parkinson's disease; Statistic parametric mapping; Striatal dopamine transporters; Transportadores de dopamina; Transportadores de dopamina en el estriado; Trastornos del movimiento