title: Sacchathridine A, a prostaglandin release inhibitor from Saccharothrix sp.
abstract: Sacchathridine A (1) was isolated from the fermentation broth of strain Saccharothrix sp. MI559-46F5. The structure was determined as a new naphthoquinone derivative with an acetylhydrazino moiety by a combination of NMR, MS spectral analyses, and chemical degradation. Compound 1 showed inhibitory activity of prostaglandin E2 release in a concentration-dependent manner from human synovial sarcoma cells, SW982, with an IC50 value of 1.0 μM, but had no effect on cell growth up to 30 μM.
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Tokyo, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan. nakaek@bikaken.or.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Nakae
authors.forename: Ikuko
authors.initials: I
authors.lastname: Kurata
authors.forename: Fukiko
authors.initials: F
authors.lastname: Kojima
authors.forename: Masayuki
authors.initials: M
authors.lastname: Igarashi
authors.forename: Masaki
authors.initials: M
authors.lastname: Hatano
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Sawa
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kubota
authors.forename: Hayamitsu
authors.initials: H
authors.lastname: Adachi
authors.forename: Akio
authors.initials: A
authors.lastname: Nomoto
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D015232:Dinoprostone / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D011448:Prostaglandin Antagonists / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013584:Sarcoma, Synovial / Q000188:drug therapy
chemical_list: D009285:Naphthoquinones; D011448:Prostaglandin Antagonists; C582688:sacchathridine A; D015232:Dinoprostone