title: 10-million-years AGO: argonaute on chromatin in yeast and human, a conserved mode of action?
abstract: Whereas in yeast the function and mode of action of nuclear RNAi are well documented, mammalian nuclear RNAi is a matter of debates. Several papers support a role for nuclear Argonaute in alternative splicing. However, the molecular mechanism remains elusive. Here, we discuss the human nuclear RNAi mechanism in light of what is known of the yeast process.
authors.affiliation: Université Paris Sud; Laboratoire Epigenetique et Cancer; Formation de Recherche en Evolution 3377; Gif-Sur-Yvette, France; Centre National de la Recherche Scientifique (CNRS); Gif-Sur-Yvette, France; Commissariat à l'Energie Atomique (CEA); Saclay; Gif-sur-Yvette, France.
authors.forename: Annick
authors.initials: A
authors.lastname: Harel-Bellan
authors.forename: Maya Ameyar
authors.initials: MA
authors.lastname: Zazoua
authors.forename: Christophe
authors.initials: C
authors.lastname: Rachez
authors.forename: Christian
authors.initials: C
authors.lastname: Muchardt
authors.forename: Eric
authors.initials: E
authors.lastname: Batsché
mesh_terms: D017398:Alternative Splicing; D060565:Argonaute Proteins / Q000235:genetics*; D005075:Biological Evolution; D002843:Chromatin / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics; D034622:RNA Interference; D062085:RNA, Long Noncoding / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*
chemical_list: D060565:Argonaute Proteins; D002843:Chromatin; D018960:Hyaluronan Receptors; D062085:RNA, Long Noncoding; D034741:RNA, Small Interfering; D012321:DNA-Directed RNA Polymerases
keywords: AGO; AS lincRNA; mammals; nuclear RNAi; splicing