title: Treatment of tinea capitis - griseofulvin versus fluconazole - a comparative study.
abstract: OBJECTIVE
  To compare the efficacy and safety of fluconazole and griseofulvin in the treatment of tinea capitis.
  
  
  METHODS
  Patients with tinea capitis (n = 113) with positive fungal cultures entered the study. The patients were divided into four groups with different treatment regimes. Two groups received griseofulvin 15 or 25 mg/kg/day and two groups received fluconazole 4 or 6 mg/kg/day, all for up to 12 weeks.
  
  
  RESULTS
  Griseofulvin was found to be slightly better than fluconazole. The lower doses for both griseofulvin and fluconazole required significantly longer treatment duration until mycological cure than the higher doses, independent of the fungus type.
  
  
  CONCLUSIONS
  Since no significant difference was found between the drugs, it is suggested that the choice should be based on tolerability, availability and cost of the drugs.
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Avner
authors.initials: A
authors.lastname: Shemer
authors.forename: Ira Bernstein
authors.initials: IB
authors.lastname: Plotnik
authors.forename: Batya
authors.initials: B
authors.lastname: Davidovici
authors.forename: Marcelo H
authors.initials: MH
authors.lastname: Grunwald
authors.forename: Ronen
authors.initials: R
authors.lastname: Magun
authors.forename: Boaz
authors.initials: B
authors.lastname: Amichai
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage*; D006118:Griseofulvin / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D007557:Israel / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D018570:Risk Assessment; D014006:Tinea Capitis / Q000188:drug therapy* / Q000453:epidemiology* / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D006118:Griseofulvin; D015725:Fluconazole