title: Graft regeneration rate and small-for-size syndrome in living donor liver transplantation.
abstract: OBJECTIVE
  Liver dysfunction, also called small-for-size syndrome (SFSS), sometimes develops despite a rapid restoration of liver mass. The aim of this study was to evaluate the relationship between the graft regeneration rate and SFSS.
  
  
  METHODS
  We retrospectively reviewed 35 adult-to-adult living donor liver transplantation (LDLT) recipients with a graft-to-recipient weight ratio (GRWR) of <0.8% using 25 right lobe grafts and 10 left lobe grafts. The graft regeneration rate was expressed with the ratio of graft volumes measured by computed tomography at postoperative day 10 to those measured during the operation. SFSS was defined as the presence of hyperbilirubinemia, coagulopathy, and ascites after surgery.
  
  
  RESULTS
  Six recipients developed SFSS. The graft regeneration rate of the SFSS (+) group was higher than the SFSS (-) group (2.12±0.39 vs. 1.70±0.29, p=0.016). In the group with a GRWR of <0.7% (n=13), 4 of 8 recipients with a graft regeneration rate of >1.86 developed SFSS, whereas none of the recipients with a graft regeneration rate of ≤1.86 developed SFSS.
  
  
  CONCLUSIONS
  The rapid graft regeneration is associated with SFSS after LDLT.
authors.forename: Shozo
authors.initials: S
authors.lastname: Mori
authors.forename: Hyeyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Min-Su
authors.initials: MS
authors.lastname: Park
authors.forename: Youngrok
authors.initials: Y
authors.lastname: Choi
authors.forename: Geun
authors.initials: G
authors.lastname: Hong
authors.forename: Nam-Joon
authors.initials: NJ
authors.lastname: Yi
authors.forename: Kwang-Woong
authors.initials: KW
authors.lastname: Lee
authors.forename: Kyung-Suk
authors.initials: KS
authors.lastname: Suh
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008115:Liver Regeneration; D016031:Liver Transplantation / Q000009:adverse effects; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012189:Retrospective Studies