title: The existence of myocardial repair: mechanistic insights and enhancements.
abstract: The lack of myocardial repair after myocardial infarction and the heart failure that eventually ensues was thought of as proof that myocardial cell regeneration and myocardial repair mechanisms do not exist. Recently, growing experimental and clinical evidence has proven this concept wrong. Cardiac stem cells and endogenous myocardial repair mechanisms do exist; however, they do not produce significant myocardial repair. Similarly, the preliminary results of stem cell therapy for myocardial repair have shown early promise but modest results. Preclinical studies are the key to understanding stem cell senescence and lack of cellular contact and vasculature in the infarcted region. Additional laboratory studies are sure to unlock the therapeutic mechanisms that will be required for significant myocardial repair.
authors.affiliation: Department of Medicine, New York Presbyterian/Weill Cornell Medical Center, New York, NY, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Schoenfeld
authors.forename: William H
authors.initials: WH
authors.lastname: Frishman
authors.forename: Annarosa
authors.initials: A
authors.lastname: Leri
authors.forename: Jan
authors.initials: J
authors.lastname: Kajstura
authors.forename: Piero
authors.initials: P
authors.lastname: Anversa
mesh_terms: D016026:Bone Marrow Transplantation / Q000379:methods; D002986:Clinical Trials as Topic; D005260:Female; D006321:Heart / Q000502:physiology*; D006333:Heart Failure / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008297:Male; D039902:Multipotent Stem Cells / Q000502:physiology; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000628:therapy; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods*