title: One-year follow-up of serum antimüllerian hormone levels in patients with cystectomy: are different sequential changes due to different mechanisms causing damage to the ovarian reserve?
abstract: OBJECTIVE
  To investigate whether the serum antimüllerian hormone (AMH) levels recover within 1 year after cystectomy for endometriomas, and to analyze the pattern of sequential changes in the serum AMH levels.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Thirty-nine patients undergoing cystectomy for unilateral endometrioma (n = 22) and bilateral endometriomas (n = 17).
  
  
  METHODS
  Serum samples collected 2 weeks before, and 1 month and 1 year after surgery were assayed for AMH levels.
  
  
  METHODS
  Assessment of the ovarian reserve damage based on alterations in the serum AMH levels and the association with parameters of endometriosis and surgery for endometriomas.
  
  
  RESULTS
  The median AMH levels were 3.56, 1.90, and 2.10 ng/mL before, 1 month after, and 1 year after surgery, respectively. Twenty patients showed higher AMH levels 1 year after surgery than 1 month after surgery (increase group); 19 patients showed lower AMH levels (decrease group). We found a statistically significant difference in the number of follicles removed by surgery between the two groups.
  
  
  CONCLUSIONS
  The decrease in the serum AMH levels caused by cystectomy can recover. Our results suggest that removal of ovarian cortex might be involved in the decrease of the ovarian reserve just after surgery, and that a continuous decrease of the ovarian reserve after cystectomy might be attributed to other mechanisms.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Sugita
authors.forename: Akira
authors.initials: A
authors.lastname: Iwase
authors.forename: Maki
authors.initials: M
authors.lastname: Goto
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nakahara
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakamura
authors.forename: Mika
authors.initials: M
authors.lastname: Kondo
authors.forename: Satoko
authors.initials: S
authors.lastname: Osuka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Mori
authors.forename: Ai
authors.initials: A
authors.lastname: Saito
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Kikkawa
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D016022:Case-Control Studies; D002452:Cell Count; D004715:Endometriosis / Q000097:blood* / Q000453:epidemiology / Q000534:rehabilitation / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects / Q000534:rehabilitation*; D006801:Humans; D007247:Infertility, Female / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology; D010535:Laparoscopy / Q000009:adverse effects / Q000534:rehabilitation; D010049:Ovarian Diseases / Q000097:blood* / Q000453:epidemiology / Q000534:rehabilitation / Q000601:surgery*; D010053:Ovary / Q000166:cytology* / Q000000981:diagnostic imaging / Q000293:injuries / Q000601:surgery; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone
keywords: Antimüllerian hormone; cystectomy; endometriomas; ovarian reserve