title: Perspectives of the metabolic engineering of terpenoid indole alkaloids in Catharanthus roseus hairy roots.
abstract: This review looks back on how the terpenoid indole alkaloid pathway and the regulatory factors in Catharanthus roseus were identified and characterized, and how metabolic engineering, including genetic engineering and metabolic profiling, was conducted based on the gained knowledge. In addition, further examination of the terpenoid indole alkaloid pathway is proposed.
authors.affiliation: Department of Chemical and Biological Engineering, Iowa State University, Ames, IA, 50011, United States.
authors.forename: Le
authors.initials: L
authors.lastname: Zhao
authors.forename: Guy W
authors.initials: GW
authors.lastname: Sander
authors.forename: Jacqueline V
authors.initials: JV
authors.lastname: Shanks
mesh_terms: D030008:Catharanthus / Q000235:genetics* / Q000378:metabolism*; D005818:Genetic Engineering / Q000379:methods; D060847:Metabolic Engineering / Q000379:methods; D018517:Plant Roots / Q000235:genetics / Q000378:metabolism*; D046948:Secologanin Tryptamine Alkaloids / Q000378:metabolism*
chemical_list: D046948:Secologanin Tryptamine Alkaloids