title: Use of TOF-SIMS in vascular biology.
abstract: Secondary ion mass spectrometry is a technique used for surface analysis. The recent introduction of metal cluster ionization sources opened the possibility to probe biological tissues, due to its reduced in-source fragmentation. Despite its limitations in mass range of the molecules analyzed, a combination of minimal sample processing, sensibility, and unsurpassed lateral resolution makes TOF-SIMS a good tool for molecular imaging in pathology.
authors.affiliation: Vascular Research Lab IIS-Fundación Jiménez Díaz, Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz (IIS-FJD), Universidad Autónoma de Madrid, Madrid, Spain.
authors.forename: Sebastián
authors.initials: S
authors.lastname: Mas
authors.forename: Raúl
authors.initials: R
authors.lastname: Pérez
authors.forename: Jesús
authors.initials: J
authors.lastname: Egido
mesh_terms: D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology; D001706:Biopsy; D001808:Blood Vessels / Q000378:metabolism* / Q000473:pathology*; D002138:Calibration; D005234:Fatty Liver / Q000378:metabolism / Q000473:pathology; D006801:Humans; D050356:Lipid Metabolism; D016464:Lysosomal Storage Diseases / Q000378:metabolism / Q000473:pathology; D013058:Mass Spectrometry / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D013997:Time Factors; D014021:Tissue Preservation