title: Optimisation of ultrasound-assisted extraction of rosehip (Rosa canina L.) with response surface methodology.
abstract: BACKGROUND
  Ultrasound-assisted extraction of polyphenols from rosehip (Rosa canina L.) was investigated. The aim of the study was to examine the extraction parameters such as extraction time (30-90 min), temperature (30-50 °C) and solvent concentration (40-100% ethanol, v/v), and to obtain the best possible combinations of these parameters by using response surface methodology.
  
  
  RESULTS
  The experiments were performed according to the face-centred central design. Total phenolic content was expressed in gallic acid equivalent (GAE) per gram of dried matter (DM). The second-order polynomial model gave a satisfactory description of the experimental data. 47.23 mg GAE g(-1) DM was predicted at the optimum operating conditions (40% EtOH composition, 50 °C of temperature, and 81.23 min of extraction time).
  
  
  CONCLUSIONS
  All of the parameters (ethanol concentration, extraction time and extraction temperature) used in this research have the significant effect on the extraction efficiency of total phenolic content in rosehip extracts (P < 0.05). The solvent concentration was proved to be the most significant effective on the yields obtained by ultrasound-assisted extraction.
authors.affiliation: Istanbul University, Engineering Faculty, Department of Chemical Engineering, 34320, Avcılar, Istanbul, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Ilbay
authors.forename: Selin
authors.initials: S
authors.lastname: Sahin
authors.forename: S İsmail
authors.initials: Sİ
authors.lastname: Kırbaşlar
mesh_terms: D005591:Chemical Fractionation / Q000379:methods*; D010936:Plant Extracts / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry; D027826:Rosa / Q000737:chemistry*; D013016:Sound
chemical_list: D010936:Plant Extracts; D059808:Polyphenols
keywords: RSM; Rosa canina L; optimisation; polyphenols; ultrasound-assisted extraction