title: Genomic medicine frontier in human solid tumors: prospects and challenges.
abstract: Recent discoveries of genomic alterations that underlie and promote the malignant phenotype, together with an expanded repertoire of targeted agents, have provided many opportunities to conduct hypothesis-driven clinical trials. The ability to profile each unique cancer for actionable aberrations by using high-throughput technologies in a cost-effective way provides unprecedented opportunities for using matched therapies in a selected patient population. The major challenges are to integrate and make biologic sense of the substantial genomic data derived from multiple platforms. We define two different approaches for the analysis, interpretation, and clinical applicability of genomic data: (1) the genomically stratified model originates from the "one test-one drug" paradigm and is currently being expanded with an upfront multicategorical approach following recent advances in multiplexed genotyping platforms; and (2) the comprehensive assessment model is based on whole-genome, -exome, and -transcriptome data and allows identification of novel drivers and subsequent therapies in the experimental setting. Tumor heterogeneity and evolution of the diverse populations of cancer cells during cancer progression, influenced by the effects of systemic treatments, will need to be addressed in the new scenario of early drug development. Logistical issues related to prescreening strategies and trial allocation, in addition to concerns in the economic and ethical domains, must be taken into consideration. Here we present a historical view of how increased understanding of cancer genomics has been translated to the clinic and discuss the prospects and challenges for further implementation of a personalized treatment strategy for human solid tumors.
authors.affiliation: Vall d'Hebron University Hospital, P. Vall d'Hebron 119-122, Barcelona, Spain 08035.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Dienstmann
authors.forename: Jordi
authors.initials: J
authors.lastname: Rodon
authors.forename: Jordi
authors.initials: J
authors.lastname: Barretina
authors.forename: Josep
authors.initials: J
authors.lastname: Tabernero
mesh_terms: D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease / Q000235:genetics; D023281:Genomics / Q000379:methods*; D006801:Humans; D062346:Molecular Medicine / Q000379:methods*; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D057285:Precision Medicine / Q000379:methods; D057170:Translational Research, Biomedical / Q000379:methods