title: A probabilistic patch-based label fusion model for multi-atlas segmentation with registration refinement: application to cardiac MR images.
abstract: The evaluation of ventricular function is important for the diagnosis of cardiovascular diseases. It typically involves measurement of the left ventricular (LV) mass and LV cavity volume. Manual delineation of the myocardial contours is time-consuming and dependent on the subjective experience of the expert observer. In this paper, a multi-atlas method is proposed for cardiac magnetic resonance (MR) image segmentation. The proposed method is novel in two aspects. First, it formulates a patch-based label fusion model in a Bayesian framework. Second, it improves image registration accuracy by utilizing label information, which leads to improvement of segmentation accuracy. The proposed method was evaluated on a cardiac MR image set of 28 subjects. The average Dice overlap metric of our segmentation is 0.92 for the LV cavity, 0.89 for the right ventricular cavity and 0.82 for the myocardium. The results show that the proposed method is able to provide accurate information for clinical diagnosis.
authors.affiliation: Biomedical Image Analysis Group, Department of Computing, Imperial College London, SW7 2RH London, UK.
authors.forename: Wenjia
authors.initials: W
authors.lastname: Bai
authors.forename: Wenzhe
authors.initials: W
authors.lastname: Shi
authors.forename: Declan P
authors.initials: DP
authors.lastname: O'Regan
authors.forename: Tong
authors.initials: T
authors.lastname: Tong
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wang
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Jamil-Copley
authors.forename: Nicholas S
authors.initials: NS
authors.lastname: Peters
authors.forename: Daniel
authors.initials: D
authors.lastname: Rueckert
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D006321:Heart / Q000033:anatomy & histology*; D006352:Heart Ventricles / Q000033:anatomy & histology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*