title: Chitosan-based dressing for the treatment of external/accessible bleedings in children with bleeding tendency.
abstract: BACKGROUND
  Bleeding episodes in patients with congenital or acquired bleeding disorders are usually managed with factor concentrates or blood products. However, external and accessible bleeds may effectively be managed with topical hemostasis.
  
  
  METHODS
  After the application of the Hemcon, a Food and Drug Administration-approved chitosan-based hemostatic dressing was used as the "last resort" to successfully control external bleeds in 2 patients with severe bleeding disorders. We describe a single-center experience with this dressing, including its use in pediatric patients as the first mode of therapy.
  
  
  RESULTS
  A total of 5 patients (median age 2 y) with severe bleeding disorders were treated with topical chitosan-based dressing for a total of 6 bleeding episodes. The dressing was used either after the failure of extensive systemic therapy or as the first choice of treatment. In 4 of the 6 episodes, bleeding ceased immediately alleviating the need for systemic therapy. There was no rebleeding after the removal of the dressing and no adverse events or local skin reactions were recorded.
  
  
  CONCLUSIONS
  Hemostatic dressings, such as the chitosan, should be encouraged for the treatment of external/accessible bleeds, especially among the pediatric patients with bleeding tendency.
authors.affiliation: National Hemophilia Center & Center of Thrombosis, The Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: Mudi
authors.initials: M
authors.lastname: Misgav
authors.forename: Gili
authors.initials: G
authors.lastname: Kenet
authors.forename: Uriel
authors.initials: U
authors.lastname: Martinowitz
mesh_terms: D000328:Adult; D001458:Bandages; D001778:Blood Coagulation Disorders / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D048271:Chitosan / Q000627:therapeutic use*; D005260:Female; D006470:Hemorrhage / Q000628:therapy; D006489:Hemostatic Techniques; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D006490:Hemostatics; D048271:Chitosan