title: Synthesis and blood glucose lowering activity of some novel benzenesulfonylthiourea derivatives substituted with 4-aryl-1-oxophthalazin-2(1H)yl-ones.
abstract: Some new benzenesulfonylthiourea derivatives substituted with phthalazones (2a-q) were synthesized by refluxing the appropriate 4-aryl-1-oxophthalazin-2(1H)yl benzenesulfonamides with isothiocyanate in dry acetone over anhydrous K₂CO₃. All the synthesized compounds were characterized on the basis of IR, (1)H NMR, MS data and elemental analysis. These synthesized compounds (2a-q) at the dose of 20 mg/kg were tested for antihyperglycemic activity in the glucose-fed hyperglycemic normal rat model and among these compounds 2f and 2m showed modest antihyperglycemic activity.
authors.affiliation: Department of Chemistry, Faculty of Science, Jamia Hamdard (Hamdard University) , New Delhi , India.
authors.forename: Shafiya
authors.initials: S
authors.lastname: Yaseen
authors.forename: Rafia
authors.initials: R
authors.lastname: Bashir
authors.forename: Syed
authors.initials: S
authors.lastname: Ovais
authors.forename: Pooja
authors.initials: P
authors.lastname: Rathore
authors.forename: Mohammed
authors.initials: M
authors.lastname: Samim
authors.forename: Kalim
authors.initials: K
authors.lastname: Javed
mesh_terms: D000818:Animals; D001557:Benzenesulfonates / Q000138:chemical synthesis* / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism*; D015195:Drug Design; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017879:Isothiocyanates / Q000737:chemistry; D008297:Male; D010793:Phthalazines / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D001557:Benzenesulfonates; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D017879:Isothiocyanates; D010793:Phthalazines; C037152:isothiocyanic acid; D013890:Thiourea; D005947:Glucose
keywords: Antihyperglycemic; diabetes; phthalazone; sulfonylthiourea