title: [Progress in the structure and function of human carboxylesterase 1].
abstract: Human carboxylesterase 1 (HCE1), belonging to a multigene serine hydrolase family, is a major liver carboxylesterase responsible for the hydrolysis and metabolism of various xenobiotics. It also plays an important role in the transportation and metabolism of endogenous cholesterol ester and free fatty acid, and is closely associated with the pathogenesis of hepatocellular carcinoma. This review describes current developments in the molecular structure, the roles in drug, toxins and lipid metabolism, and the early diagnosis for hepatocellular carcinoma of human carboxylesterase 1.
authors.affiliation: Medical College of Hunan Normal University, Changsha 410006, Hunan, China.
authors.forename: Jinying
authors.initials: J
authors.lastname: Tong
authors.forename: Yinsha
authors.initials: Y
authors.lastname: Yi
authors.forename: Pengrong
authors.initials: P
authors.lastname: Cao
authors.forename: Caiyun
authors.initials: C
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lü
mesh_terms: D002265:Carboxylic Ester Hydrolases / Q000235:genetics* / Q000502:physiology*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis; D002788:Cholesterol Esters / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis; D015262:Xenobiotics / Q000378:metabolism
chemical_list: D002788:Cholesterol Esters; D005230:Fatty Acids, Nonesterified; D015262:Xenobiotics; D002265:Carboxylic Ester Hydrolases; C474609:CES1 protein, human