title: Manganese homeostasis and transport.
abstract: The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson's disease (PD) and sensitivity to Mn.
authors.affiliation: Department of Pharmacology and Toxicology, University at Buffalo School of Medicine, 11 Cary Hall, Buffalo, NY, 14214, USA.
authors.forename: Jerome
authors.initials: J
authors.lastname: Roth
authors.forename: Silvia
authors.initials: S
authors.lastname: Ponzoni
authors.forename: Michael
authors.initials: M
authors.lastname: Aschner
mesh_terms: D006706:Homeostasis; D006801:Humans; D008345:Manganese; D020149:Manganese Poisoning; D008928:Mitochondria; D010300:Parkinson Disease
chemical_list: D008345:Manganese