title: Malignant epithelioid hemangioendothelioma progressing after chemotherapy and Interferon treatment: a case presentation and a brief review of the literature.
abstract: Epithelioid hemangioendothelioma is a rare, low-grade malignant vascular tumour. It is frequently seen in the liver, but can occur in the lungs, bones, and other soft tissues. Although survival time might be reasonable in cases that can undergo liver transplantation, there is no consensus on the treatment of metastatic patients. We report a 24-year-old female patient with rapidly progressing malignant epithelioid hemangioendothelioma that presented with acute abdominal distension. The patient was refractory to anthracycline and Interferon treatment and died 6.5 months after the diagnosis.
authors.affiliation: Department of Medical Oncology, Izmir Ataturk Training and Research Hospital, Ankara, Turkey. demir.lut-fiye77@gmail.com
authors.forename: Lutfiye
authors.initials: L
authors.lastname: Demir
authors.forename: Alper
authors.initials: A
authors.lastname: Can
authors.forename: Rukiye
authors.initials: R
authors.lastname: Oztop
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dirican
authors.forename: Vedat
authors.initials: V
authors.lastname: Bayoglu
authors.forename: Murat
authors.initials: M
authors.lastname: Akyol
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Kucukzeybek
authors.forename: Cigdem
authors.initials: C
authors.lastname: Erten
authors.forename: Isil
authors.initials: I
authors.lastname: Somali
authors.forename: Mustafa Oktay
authors.initials: MO
authors.lastname: Tarhan
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D007372:Interferons / Q000627:therapeutic use; D050152:Intra-Abdominal Fat / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D018952:Antigens, CD34; D000970:Antineoplastic Agents; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D007372:Interferons