title: [Effects of curcumin intake on kidney and liver pathological changes in T2DM rats].
abstract: OBJECTIVE
  To investigate whether curcumin intake could improve kidney, liver pathological changes in type 2 diabetes (T2DM) rats.
  
  
  METHODS
  100 male Wistar rats were randomly divided into two groups: 10 rats in the control group; 90 in the T2DM model rats, the using low-dose treptozotocin (30 mg/kg BW) combined high sugar and high fat diet to induce T2DM model. After the success of the model induction, 39 T2DM rats met the selection criteria, which were randomly divided into 4 groups: T2DM model control group, low-dose curcumin group (50 mg/kg BW), curcumin dose group (150 mg/kg BW) and curcumin high-dose group (250 mg/kg BW), given intervention. After 45 days treatment, rats from each group were randomly selected four for pathological testing and observation of kidney and liver changes.
  
  
  RESULTS
  Compared with the control group, the results showed that blood glucose and lipids in T2DM model group were significantly increased (P < 0.05). Compared to the T2DM control group, curcumin treatment significant improved kidney and liver pathological changes.
  
  
  CONCLUSIONS
  Curcumin can improve liver and kidney pathological changes in T2DM rats.
authors.affiliation: School of Public Health, Harbin Medical University, Harbin 150081, China. changhao2002sun@gmail.com
authors.forename: Changhao
authors.initials: C
authors.lastname: Sun
authors.forename: Yuling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tian
authors.initials: T
authors.lastname: Kong
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Rennan
authors.initials: R
authors.lastname: Feng
authors.forename: Guan
authors.initials: G
authors.lastname: Wang
mesh_terms: D000818:Animals; D003474:Curcumin / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000473:pathology; D007668:Kidney / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003474:Curcumin