title: Phase synchronization in brain networks derived from correlation between probabilities of recurrences in functional MRI data.
abstract: It is increasingly being recognized that resting state brain connectivity derived from functional magnetic resonance imaging (fMRI) data is an important marker of brain function both in healthy and clinical populations. Though linear correlation has been extensively used to characterize brain connectivity, it is limited to detecting first order dependencies. In this study, we propose a framework where in phase synchronization (PS) between brain regions is characterized using a new metric "correlation between probabilities of recurrence" (CPR) and subsequent graph-theoretic analysis of the ensuing networks. We applied this method to resting state fMRI data obtained from human subjects with and without administration of propofol anesthetic. Our results showed decreased PS during anesthesia and a biologically more plausible community structure using CPR rather than linear correlation. We conclude that CPR provides an attractive nonparametric method for modeling interactions in brain networks as compared to standard correlation for obtaining physiologically meaningful insights about brain function.
authors.affiliation: Department of Electrical Communication Engineering, Indian Institute of Science, Bangalore-560012, India.
authors.forename: D
authors.initials: D
authors.lastname: Rangaprakash
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Hu
authors.forename: Gopikrishna
authors.initials: G
authors.lastname: Deshpande
mesh_terms: D000777:Anesthetics / Q000494:pharmacology; D001921:Brain / Q000098:blood supply* / Q000187:drug effects / Q000502:physiology; D001931:Brain Mapping; D018592:Cross-Over Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D008959:Models, Neurological; D009415:Nerve Net / Q000098:blood supply / Q000502:physiology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D011336:Probability; D015742:Propofol / Q000494:pharmacology; D013997:Time Factors; D014706:Verbal Learning / Q000187:drug effects; D014851:Wakefulness
chemical_list: D000777:Anesthetics; D010100:Oxygen; D015742:Propofol