title: Targeted delivery of siRNA to differentiated murine myotubes in culture by a conjugate of cationic oligopeptide with FS2 venom.
abstract: A conjugate of the ligand of FS2 venom dihydropyridine receptors with a cationic arginine-containing oligopeptide was synthesized. It was found that the conjugate provides siRNA delivery to murine myotubes differentiated in vitro. The effect of RNA interference with the use of siRNA complexes with the conjugate was observed when siRNA concentrations were an order of magnitude lower than those used in the case of siRNA complexes with a non-conjugated oligopeptide.
authors.affiliation: Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Furalyov
authors.forename: I V
authors.initials: IV
authors.lastname: Kravchenko
authors.forename: V O
authors.initials: VO
authors.lastname: Popov
mesh_terms: D000818:Animals; D002412:Cations / Q000737:chemistry; D002454:Cell Differentiation; D002478:Cells, Cultured; D016503:Drug Delivery Systems; D008024:Ligands; D051379:Mice; D018485:Muscle Fibers, Skeletal / Q000166:cytology / Q000378:metabolism*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism*; D012910:Snake Venoms
chemical_list: D002412:Cations; D008024:Ligands; D009842:Oligopeptides; D010455:Peptides; D034741:RNA, Small Interfering; D012910:Snake Venoms; C093284:toxin FS2