title: Mesoporous zirconia thin films with three-dimensional pore structures and their application to electrochemical glucose detection.
abstract: Mesoporous zirconia thin films (MZFs) were synthesized using zirconium hydroxide sol particles and a structure directing agent, Pluronic F127 (PEO106PPO70PEO106, EO = ethylene oxide, PO = propylene oxide). By controlling the F127/Zr ratio, we obtained two distinct MZFs with one in the Fmmm structure and the other in the P63/mmc structure. The pore structures of these films were characterized by low-angle X-ray diffraction, grazing incidence small-angle X-ray scattering, electron microscopy, and N2 sorption measurement. The Fmmm structure has interconnected pores and the P63/mmc structure has less accessible pores. The MZFs were functionalized with glucose oxidase (GOx) and were studied for their potentials as an electrochemical sensor for glucose. The GOx-functionalized MZF electrodes show high sensitivity to glucose in a broad range of glucose concentration of 0.025 - 6.8 mM, which can be attributed to their biocompatibility providing a favorable microenvironment for GOx immobilization and to their 3D pore structures with good accessibility of pores.
authors.affiliation: Department of Chemistry, BK-21 School of Chemical Materials Science, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Young-Seon
authors.initials: YS
authors.lastname: Ko
authors.forename: Young-Uk
authors.initials: YU
authors.lastname: Kwon
mesh_terms: D055664:Electrochemical Techniques / Q000295:instrumentation* / Q000379:methods*; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D005947:Glucose / Q000032:analysis*; D005949:Glucose Oxidase / Q000737:chemistry / Q000378:metabolism; D006878:Hydroxides / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D020442:Poloxamer / Q000737:chemistry; D016062:Porosity; D014961:X-Ray Diffraction; D015040:Zirconium / Q000737:chemistry*
chemical_list: D004800:Enzymes, Immobilized; D006878:Hydroxides; D020442:Poloxamer; C470523:zirconium hydroxide; D015040:Zirconium; D005949:Glucose Oxidase; D005947:Glucose