title: Continuous-flow synthesis of adipic acid from cyclohexene using hydrogen peroxide in high-temperature explosive regimes.
abstract: Safe only in a microreactor! The synthesis of adipic acid from cyclohexene by tungstic acid-catalyzed oxidation using hydrogen peroxide following the classical Noyori protocol can be accomplished in good yields with residence times as short as 20 min at 140 °C using a safe and scalable microreactor environment. Under these intensified conditions the use of a phase-transfer catalyst is not required.
authors.affiliation: Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
authors.forename: Markus
authors.initials: M
authors.lastname: Damm
authors.forename: Bernhard
authors.initials: B
authors.lastname: Gutmann
authors.forename: C Oliver
authors.initials: CO
authors.lastname: Kappe
mesh_terms: D000272:Adipates / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D053138:Cyclohexenes / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D013696:Temperature
chemical_list: D000272:Adipates; D053138:Cyclohexenes; C052568:cyclohexene; C029900:adipic acid; D006861:Hydrogen Peroxide