title: Subtractionless first-pass single contrast medium dose peripheral MR angiography using two-point Dixon fat suppression.
abstract: OBJECTIVE
  To investigate the feasibility of subtractionless first-pass single contrast medium dose (0.1 mmol/kg) peripheral magnetic resonance angiography (MRA) at 1.5 T using two-point Dixon fat suppression and compare it with conventional subtraction MRA in terms of image quality.
  
  
  METHODS
  Twenty-eight patients (13 male, 15 female; mean age ± standard deviation, 66 ± 16 years) with known or suspected peripheral arterial disease underwent subtractionless and subtraction first-pass MRA at 1.5 T using two-point Dixon fat suppression. Results were compared with regard to vessel-to-background contrast. A phantom study was performed to assess the signal-to-noise ratio (SNR) of both MRA techniques. Two experienced observers scored subjective image quality. Agreement regarding subjective image quality was expressed in quadratic weighted κ values.
  
  
  RESULTS
  Vessel-to-background contrast improved in all anatomical locations with the subtractionless method versus the subtraction method (all P < 0.001). Subjective image quality was uniformly higher with the subtractionless method (all P < 0.03, except for the aorto-iliac arteries for observer 1, P = 0.052). SNR was 15 % higher with the subtractionless method (31.9 vs 27.6).
  
  
  CONCLUSIONS
  This study demonstrates the feasibility of subtractionless first-pass single contrast medium dose lower extremity MRA. Moreover, both objective and subjective image quality are better than with subtraction MRA.
  
  
  CONCLUSIONS
  • MRA is increasingly used for vascular applications. • Dixon imaging offers an alternative to image subtraction for fat suppression. • Subtractionless first-pass peripheral MRA is possible using two-point Dixon fat suppression. • Subtractionless peripheral MRA is possible at 1.5 T a single contrast medium dose. • Subtractionless first-pass peripheral MRA provides good image quality with few non-diagnostic studies.
authors.affiliation: Department of Radiology, Utrecht University Medical Center, Utrecht, The Netherlands. t.leiner@umcutrecht.nl
authors.forename: Tim
authors.initials: T
authors.lastname: Leiner
authors.forename: Jesse
authors.initials: J
authors.lastname: Habets
authors.forename: Bastiaan
authors.initials: B
authors.lastname: Versluis
authors.forename: Liesbeth
authors.initials: L
authors.lastname: Geerts
authors.forename: Eveline
authors.initials: E
authors.lastname: Alberts
authors.forename: Niels
authors.initials: N
authors.lastname: Blanken
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hendrikse
authors.forename: Evert-Jan
authors.initials: EJ
authors.lastname: Vonken
authors.forename: Holger
authors.initials: H
authors.lastname: Eggers
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction / Q000379:methods; D002648:Child; D003287:Contrast Media / Q000494:pharmacology; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D058729:Peripheral Arterial Disease / Q000175:diagnosis* / Q000473:pathology*; D019047:Phantoms, Imaging; D059629:Signal-To-Noise Ratio; D013382:Subtraction Technique; D055815:Young Adult
chemical_list: D003287:Contrast Media