title: Restless legs syndrome as the presenting symptom of multiple myeloma.
abstract: We report a patient affected by restless legs syndrome as the presenting symptom of multiple myeloma, a hematologic malignancy characterized by clonal proliferation of plasma cells in the bone marrow and monoclonal immunoglobulin in the blood and/or urine.
authors.affiliation: Sleep Research Centre, Department of Neurology I.C., Oasi Institute for Research on Mental Retardation and Brain Aging, Via C. Ruggero 73, 94018 Troina, Italy. aricodebora@hotmail.com
authors.forename: Debora
authors.initials: D
authors.lastname: Aricò
authors.forename: Alberto
authors.initials: A
authors.lastname: Raggi
authors.forename: Maddalena
authors.initials: M
authors.lastname: Siragusa
authors.forename: Marco
authors.initials: M
authors.lastname: Zucconi
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ferri
mesh_terms: D000368:Aged; D000588:Amines / Q000627:therapeutic use; D018798:Anemia, Iron-Deficiency / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D000978:Antiparkinson Agents / Q000627:therapeutic use; D052160:Benzothiazoles / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D000077206:Gabapentin; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D017286:Polysomnography / Q000379:methods; D000077487:Pramipexole; D012148:Restless Legs Syndrome / Q000188:drug therapy / Q000209:etiology*; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use
chemical_list: D000588:Amines; D000978:Antiparkinson Agents; D052160:Benzothiazoles; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D000077487:Pramipexole
keywords: Secondary restless legs syndrome; iron deficiency; multiple myeloma; periodic leg movements during sleep; pruritus