title: [In vitro activity of doripenem against strains from pediatric diseases and strains causing purulent meningitis].
abstract: This study evaluated the in vitro activity of doripenem (DRPM) against 200 Streptococcus pneumoniae and 197 Haemophilus influenzae from children and adults in 2007, 50 H. influenzae type b in 2006, 20 Listeria monocytogenes in 1990-2005, 23 Neisseria meningitidis in 2007-2009 and 83 Bordetella pertussis in 1989-2003. All strains were isolated from Japanese clinical facilities. We also investigated in vitro activity of other carbapenems (meropenem, imipenem, panipenem, biapenem), cephems (ceftriaxone, cefotaxime), ampicillin and clarithromycin. The all MICs were determined by a broth micro dilution method or an agar dilution method according to CLSI. The MIC90(s) of DRPM against S. pneumoniae and H. influenzae from children were 0.25 microg/mL, 1 microg/mL, respectively, which were similar to strains from adults. These results suggested that antibacterial activity of DRPM is not variable by patient's age. DRPM also showed excellent activities against H. influenzae type b, L. monocytogenes and N. meningitidis, which cause purulent meningitis, and B. pertussis causing whooping cough more than the other carbapenems. DRPM showed superior activities against serious strains of pediatric infection diseases.
authors.affiliation: Medicinal Research Laboratories, Shionogi & Co., Ltd.
authors.forename: Merime
authors.initials: M
authors.lastname: Ohta
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Toba
authors.forename: Akinobu
authors.initials: A
authors.lastname: Ito
authors.forename: Rio
authors.initials: R
authors.lastname: Nakamura
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Tsuji
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D015780:Carbapenems / Q000494:pharmacology*; D002648:Child; D000077726:Doripenem; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D016920:Meningitis, Bacterial / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013492:Suppuration / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D000077726:Doripenem