title: Recipient IL-6-572C/G genotype is associated with reduced incidence of acute rejection following liver transplantation.
abstract: OBJECTIVE
  Acute rejection resulting from alloimmune responses is a major risk factor affecting patient survival following liver transplantation. Since interleukin (IL)-6 can mediate acute rejection, the association between IL-6 gene single nucleotide polymorphisms (SNPs) and incidence of acute rejection in liver transplant recipients was investigated.
  
  
  METHODS
  Patients who received liver transplant between January 2005 and December 2010 were typed for IL6-572C/G (rs1800796) polymorphisms using the snapshot technique. Association between genotype and acute rejection was analysed using the SNP Statistics website: http://bioinfo.iconcologia.net/snpstats/start.htm. Allelic and genotypic distributions for rs1800796 were compared among 335 patients with or without acute rejection within the first 6 months following liver transplant.
  
  
  RESULTS
  Incidence of acute rejection was 11.94%. A heterozygous CG genotype for IL6-572C/G was associated with a lower acute rejection rate compared with homozygous CC or GG genotypes.
  
  
  CONCLUSIONS
  IL6-572 CG genotype may be related to protection from acute rejection following liver transplant in Han Chinese patients.
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Yao
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Feng
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Yu
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Xie
authors.forename: Li-Xian
authors.initials: LX
authors.lastname: Zhu
authors.forename: Zhe
authors.initials: Z
authors.lastname: Yang
authors.forename: Ba-Jin
authors.initials: BJ
authors.lastname: Wei
authors.forename: Shu-Sen
authors.initials: SS
authors.lastname: Zheng
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
mesh_terms: D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006084:Graft Rejection / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D006801:Humans; D015994:Incidence; D015850:Interleukin-6 / Q000235:genetics*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6
keywords:   IL6-572C/G; Acute rejection; interleukin-6 (IL-6); liver transplantation; rs1800796; single nucleotide polymorphism (SNP)