title: Hypolipidemic activity of the chitooligosaccharides from Clanis bilineata (Lepidoptera), an edible insect.
abstract: Clanis bilineata (CB) is an edible insect, and CB larvae (CBL) are widely consumed in China, yielding a large number of CBL skin (CBLS). In this study, chitooligosaccharides (COS) from CBLS were prepared and their hypolipidemic activity was determined in rats. Thirty-six male Sprague-Dawley rats in 3 groups were fed diets containing either high fat (HF) or COS, or a normal fat (NF) for 6 weeks. Compared with HF group, COS group showed decreased body weight gain, plasma triacylglycerol (TG), total cholesterol (TC), and plasma low-density lipoprotein cholesterol (LDL-C) level. Fecal fat and cholesterol of the COS group were higher than those of NF and HF groups. The results indicated that COS could be a suitable alterative hypolipidemic source for humans.
authors.affiliation: School of Marine Science and Technology, HuaiHai Institute of Technology, 59 Cangwu Road, Xinpu 222005, China.
authors.forename: Zhenqiang
authors.initials: Z
authors.lastname: Xia
authors.forename: Jinhua
authors.initials: J
authors.lastname: Chen
authors.forename: Shengjun
authors.initials: S
authors.lastname: Wu
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat; D005243:Feces / Q000737:chemistry; D005502:Food; D006801:Humans; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007814:Larva / Q000737:chemistry*; D007915:Lepidoptera / Q000737:chemistry*; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D009844:Oligosaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D009844:Oligosaccharides; D014280:Triglycerides