title: Associations between the insertion/deletion polymorphism of the angiotensin-converting enzyme and susceptibility to aortic aneurysms: A meta-analysis.
abstract: BACKGROUND
  The purpose of this study is to examine whether the insertion (I) and deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) confers susceptibility to aortic aneurysms (AAs).
  
  
  METHODS
  A meta-analysis was conducted on the associations between the ACE I/D polymorphism and all AAs and abdominal aortic aneurysms (AAAs).
  
  
  RESULTS
  Ten studies consisting of 2784 cases and 2682 controls were available for the meta-analysis. Meta-analysis showed a significant association between the D allele and all types of AA (OR 1.378, 95% CI 1.103-1.723, p = 0.005) and AAA (OR 1.274, 95% CI 1.004-1.617, p = 0.046). Meta-analysis of both the DD genotype and the DD vs. II genotype showed an association with AAAs. Stratification by ethnicity indicated an association between the D allele of the ACE I/D polymorphism and AAAs in Europeans (OR = 1.338, 95% CI = 1.026-1.745, p = 0.031), but not in Asians (OR = 0.927, 95% CI = 0.660-1.303, p = 0.663). Furthermore, analysis using the recessive model, dominant model, and homozygote contrast all showed the same pattern for the D allele.
  
  
  CONCLUSIONS
  Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to AAAs in European populations.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Korea.
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Korea.
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Korea lyhcgh@korea.ac.kr.
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
mesh_terms: D000483:Alleles; D001014:Aortic Aneurysm / Q000453:epidemiology* / Q000235:genetics*; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Angiotensin-converting enzyme; abdominal aortic aneurysm; meta-analysis; polymorphism