title: [p53-independent signaling pathway in DNA damage-induced cell apoptosis].
abstract: p53 is considered as the "master regulator" in DNA damage-induced cell apoptosis. However, p53 is the most frequently mutated gene in human cancers (more than 50 %). Thus the research of p53-independent pathway in cell apoptosis may ultimately provide new therapeutic opportunities for many cancers. It has been shown that Caspase 2, p73, p63, and NF-kappa B-related signaling pathways are involved in DNA damage-induced, p53-independent cell apoptosis. This article reviews the recent research progress in these signaling pathways.
authors.affiliation: Zhejiang University School of Public Health, Hangzhou 310058, China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D004249:DNA Damage; D006801:Humans; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53