title: [Genetics and stressful life events interact in depression].
abstract: The aim of the present review was to present clinical aspects of recent research in genes, the experience of stressful life events and depression. 60-70% experience a moderate to severe stressful life event half a year prior to the first onset of depression, whereas later depressive episodes to a lesser extent are preceded by stressful life events. Clinical features do not differ between depressions with or without prior stressful life events. Certain genetic variations in the serotonin receptor system seem to increase the risk of developing depression in relation to experiencing stressful life events.
authors.affiliation: Psykiatrisk Center København, Afdeling O, Rigshospitalet, Afsnit 6233, Blegdamsvej 9, 2100 København Ø, Denmark. lars.vedel.kessing@regionh.dk
authors.forename: Lars Vedel
authors.initials: LV
authors.lastname: Kessing
authors.forename: Jens Drachmann
authors.initials: JD
authors.lastname: Bukh
mesh_terms: D003863:Depression / Q000235:genetics*; D003866:Depressive Disorder / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008016:Life Change Events; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013315:Stress, Psychological / Q000235:genetics
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins