title: Gold amides as anticancer drugs: synthesis and activity studies.
abstract: Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells.
authors.affiliation: MRC Genome Damage and Stability Centre, University of Sussex, Brighton, BN1 9RQ, UK.
authors.forename: Sonya
authors.initials: S
authors.lastname: Newcombe
authors.forename: Mariusz
authors.initials: M
authors.lastname: Bobin
authors.forename: Amruta
authors.initials: A
authors.lastname: Shrikhande
authors.forename: Chris
authors.initials: C
authors.lastname: Gallop
authors.forename: Yannick
authors.initials: Y
authors.lastname: Pace
authors.forename: Helen
authors.initials: H
authors.lastname: Yong
authors.forename: Rebecca
authors.initials: R
authors.lastname: Gates
authors.forename: Shuvashri
authors.initials: S
authors.lastname: Chaudhuri
authors.forename: Mark
authors.initials: M
authors.lastname: Roe
authors.forename: Eva
authors.initials: E
authors.lastname: Hoffmann
authors.forename: Eddy M E
authors.initials: EM
authors.lastname: Viseux
mesh_terms: D000577:Amides / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004847:Epithelial Cells / Q000187:drug effects; D006046:Gold / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009550:Nigericin / Q000494:pharmacology; D050607:Organogold Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000970:Antineoplastic Agents; D050607:Organogold Compounds; D006046:Gold; D009550:Nigericin