title: Treatment of osteochondral lesions of the talus with particulated juvenile cartilage.
abstract: BACKGROUND
  Numerous modalities are used today to treat symptomatic osteochondral lesions in the ankle. However, there are ongoing challenges with the treatment of certain lesions, and concerns exist regarding long-term effectiveness.
  
  
  METHODS
  The purpose of the study was to collect clinical outcomes of pain and function in retrospectively and prospectively enrolled patients treated with particulated juvenile cartilage for symptomatic osteochondral lesions in the ankle. This study collected outcomes and incidence of reoperations in standard clinic patients. The analysis presented here includes final follow-up to date for 12 males and 11 females representing 24 ankles. Subjects had an average age at surgery of 35.0 years and an average body mass index of 28 ± 5.8. Fourteen ankles had failed at least 1 prior bone marrow stimulation procedure. The average lesion size was 125 ± 75 mm(2), and the average depth was 7 ± 5 mm. In conjunction with the treatment, 9 (38%) ankles had 1 concomitant procedure and 9 (38%) had more than 1 concomitant procedure. Clinical evaluations were performed with an average follow-up of 16.2 months.
  
  
  RESULTS
  Average outcome scores at final follow-up were American Orthopaedic Foot & Ankle Society Ankle-Hindfoot Scale 85 ± 18 with 18 (78%) ankles demonstrating good to excellent scores, Short-Form 12 Health Survey (SF12) physical composite score 46 ± 10, SF12 mental health composite score 55 ± 7.1, Foot and Ankle Ability Measure (FAAM) activities of daily living 82 ± 14, FAAM Sports 63 ± 27, and 100-mm visual analog scale for pain 24 ± 25. Outcomes data divided by lesion size demonstrated 92% (12/13) good to excellent results in lesions 10 mm or larger and those smaller than 15 mm. To date, 1 partial graft delamination has been reported at 16 months.
  
  
  CONCLUSIONS
  Preliminary data from a challenging clinical population with large, symptomatic osteochondral lesions in the ankle suggest that treatment with particulated juvenile cartilage could improve function and decrease pain. Longer follow-up and additional subjects are needed to evaluate improvement level and ideal patient indications.
  
  
  METHODS
  Level IV, case series.
authors.affiliation: Minnesota Orthopedic Sports Medicine Institute (MOSMI) at Twin Cities Orthopedics, and Fairview/MOSMI Medicine Fellowship Faculty, Edina, MN, USA.
authors.forename: J Chris
authors.initials: JC
authors.lastname: Coetzee
authors.forename: Eric
authors.initials: E
authors.lastname: Giza
authors.forename: Lew C
authors.initials: LC
authors.lastname: Schon
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Berlet
authors.forename: Steven
authors.initials: S
authors.lastname: Neufeld
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Stone
authors.forename: Erin L
authors.initials: EL
authors.lastname: Wilson
mesh_terms: D000328:Adult; D000368:Aged; D016512:Ankle Injuries / Q000601:surgery*; D001182:Arthroscopy; D018786:Bone Substitutes / Q000008:administration & dosage*; D002358:Cartilage, Articular / Q000293:injuries / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010007:Osteochondritis / Q000601:surgery; D011446:Prospective Studies; D012086:Reoperation; D013628:Talus; D014184:Transplantation, Homologous
chemical_list: D018786:Bone Substitutes
keywords: articular cartilage repair; cartilage allograft; clinical outcomes; lesion size; osteochondral defects; talus