title: Neolignans and phenylpropanoids from the roots of Piper taiwanense and their antiplatelet and antitubercular activities.
abstract: Bioassay-guided fractionation of roots from Piper taiwanense led to isolation of three neolignans, diallylcatechol (1) and neotaiwanensols A, B (2, 3), two diphenylpropanoid ethers, taiwandimerols A, B (4, 5), with one phenylpropanoid, 2,3-diacetoxy-1-methoxy-5-allylbenzene (6), previously unknown in nature, together with 18 known compounds (7-24). Their structures were elucidated by spectroscopic evidence. Among the isolates, hydroxychavicol acetate (7), and 4-allylcatechol (8) showed potent inhibitory activities against platelet aggregation induced by collagen, with IC50 values of 2.1, and 5.3 μM, respectively. Hydroxychavicol acetate (7), 4-allylcatechol (8), and trans-caffeicaldehyde (9) showed antitubercular activities against Mycobacterium tuberculosis H37Rv, with MIC values of 30.3, 27.6, and 25.5 μg/mL, respectively.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
authors.forename: Si
authors.initials: S
authors.lastname: Chen
authors.forename: Hung-Yi
authors.initials: HY
authors.lastname: Huang
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Chin-Chung
authors.initials: CC
authors.lastname: Wu
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Chien-Fang
authors.initials: CF
authors.lastname: Peng
authors.forename: Hsun-Shou
authors.initials: HS
authors.lastname: Chang
authors.forename: Chyi-Jia
authors.initials: CJ
authors.lastname: Wang
authors.forename: Su-Ling
authors.initials: SL
authors.lastname: Wong
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031701:Piper / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000925:Anticoagulants; D000995:Antitubercular Agents; D017705:Lignans; D010666:Phenylpropionates
keywords: Antiplatelet activity; Antitubercular activity; Neolignan; Phenylpropanoid; Piper taiwanense; Piperaceae; Root