title: Left ventricular assist devices: from the bench to the clinic.
abstract: The development of ventricular assist devices (VADs) over the past 5 decades as therapy for advanced heart failure (HF) has been extraordinary. Since the original VAD design by Michael DeBakey in the early 1960s, numerous devices for mechanical circulatory support have been engineered, assessed in preclinical studies, applied to human patients in large multicenter clinical trials, and now, select devices are Food and Drug Administration-approved therapy for advanced HF patients. This review highlights select examples of durable VADs from the engineering aspect of design and conception to experimental studies and clinical application underscoring the remarkable progression of such technology to now becoming the standard of care for many advanced HF patients.
authors.affiliation: Kaufman Center for Heart Failure, Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
authors.forename: Sangjin
authors.initials: S
authors.lastname: Lee
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
authors.forename: Leonard
authors.initials: L
authors.lastname: Golding
authors.forename: Nader
authors.initials: N
authors.lastname: Moazami
authors.forename: Randall C
authors.initials: RC
authors.lastname: Starling
mesh_terms: D004059:Diffusion of Innovation; D005544:Forecasting; D006333:Heart Failure / Q000628:therapy*; D006353:Heart-Assist Devices / Q000639:trends*; D006801:Humans; D011474:Prosthesis Design