title: Aptamer-conjugated magnetic nanoparticles enable efficient targeted detection of integrin αvβ3 via magnetic resonance imaging.
abstract: An understanding of neovascularization and/or angiogenesis in cancer is acutely required for effective cancer therapy due to concerns about tumor growth and metastasis. In particular, integrin αvβ3 is closely associated with cell migration and invasion during angiogenesis. Hence, we developed aptamer(αvβ3)-conjugated magnetic nanoparticles (Apt(αvβ3)-MNPs) to enable precise detection of integrin-expressing cancer cells using magnetic resonance imaging. Apt(αvβ3)-MNPs exhibited not only cytocompatibility, but also an efficient targeting ability with high magnetic sensitivity through in vitro/in vivo studies. The results of this study demonstrate that Apt(αvβ3)-MNPs have the potential to be used for accurate tumor diagnosis and therapy.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, South Korea.
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Lim
authors.forename: Bongjune
authors.initials: B
authors.lastname: Kim
authors.forename: Yuna
authors.initials: Y
authors.lastname: Choi
authors.forename: Youngjun
authors.initials: Y
authors.lastname: Ro
authors.forename: Eun-Jin
authors.initials: EJ
authors.lastname: Cho
authors.forename: Jung Hwan
authors.initials: JH
authors.lastname: Lee
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Ryu
authors.forename: Jin-Suck
authors.initials: JS
authors.lastname: Suh
authors.forename: Seungjoo
authors.initials: S
authors.lastname: Haam
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Huh
mesh_terms: D000818:Animals; D052158:Aptamers, Peptide / Q000737:chemistry / Q000494:pharmacology; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000737:chemistry*; D060526:Magnetic Fields; D018810:Magnetic Resonance Angiography; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D011859:Radiography
chemical_list: D052158:Aptamers, Peptide; D003287:Contrast Media; D039302:Integrin alphaVbeta3
keywords: angiogenesis; aptamer; integrin avb3; magnetic nanoparticle; magnetic resonance imaging