title: Impaction grafting of the acetabulum with ceramic bone graft substitute mixed with femoral head allograft: high survivorship in 43 patients with a median follow-up of 7 years: a follow-up report.
abstract: OBJECTIVE
  Restoration of bone stock at revision hip surgery remains a challenge. Alternative graft materials with suitable mechanical properties for impaction grafting have been sought due to issues with infection, antigenicity, cost, and availability of allograft. We have previously presented good short-term results of the use of BoneSave, a biphasic porous ceramic bone graft substitute, consisting of sintered 80% tricalcium phosphate and 20% hydroxyapatite, in a 50:50 mix with femoral head allograft. We now present the medium-term results.
  
  
  METHODS
  We conducted a retrospective review of a cohort of 43 consecutive patients undergoing impaction grafting of contained acetabular defects by multiple surgeons at a single center. 34 patients received uncemented acetabular components and 9 received cemented components. Patients were followed up radiographically and with the self-reported satisfaction scale (SAPS), Oxford hip score (OHS), and the Short-Form 12 (SF12) health survey. Kaplan-Meier survivorship analysis was performed with revision of the acetabular component, revision of any part of the construct, and reoperation as endpoints.
  
  
  RESULTS
  The fate of all cases was known. Median follow-up of the surviving patients was 80 (69-106) months. 15 patients died during the follow-up period, 14 with their construct in situ. The survivorship of the grafted acetabulum and acetabular component was 94% (95% CI: 99-78) at 7 years. 1 patient had been revised for aseptic loosening of the acetabulum and 1 for deep infection. The mean OHS was 31 (SD 12), the mean SF12 physical-component score (PCS) was 38 (SD 13), the median SAPS was 83 (0-100), and the median SF12 mental-component score (MCS) was 55 (23-65). The graft material became incorporated in all 3 zones of the acetabulum in 23 out of 24 cases that had complete radiographic follow-up.
  
  
  CONCLUSIONS
  These medium-term results show that BoneSave is a reliable material for impaction grafting of the acetabulum when used in conjunction with femoral head allograft.
authors.affiliation: Musculoskeletal Research Unit, Department of Academic Orthopaedics, University of Bristol, Lower Level AOC, Southmead Hospital, Westbury-on-Trym, UK. michael.whitehouse@bristol.ac.uk
authors.forename: Michael R
authors.initials: MR
authors.lastname: Whitehouse
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Dacombe
authors.forename: Jason C J
authors.initials: JC
authors.lastname: Webb
authors.forename: Ashley W
authors.initials: AW
authors.lastname: Blom
mesh_terms: D000077:Acetabulum / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000379:methods*; D016025:Bone Transplantation / Q000009:adverse effects / Q000379:methods*; D002516:Ceramics; D005260:Female; D005270:Femur Head / Q000637:transplantation*; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012086:Reoperation; D012189:Retrospective Studies; D015996:Survival Rate; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome