title: Synthesis, characterization, in vitro antimicrobial, and U2OS tumoricidal activities of different coumarin derivatives.
abstract: BACKGROUND
  Coumarin and its derivatives are biologically very active. It was found that the enhanced activities are dependent on the coumarin nucleus. Biological significance of these compounds include anti-bacterial, anti-thrombotic and vasodilatory, anti-mutagenic, lipoxygenase and cyclooxygenase inhibition, scavenging of reactive oxygen species, and anti-tumourigenic. Our interest in medicinal chemistry of dicoumarol compounds have been developed by keeping in view the importance of coumarins along with its derivatives in medicinal chemistry. All the synthesized compounds were fully characterized by spectroscopic and analytical techniques and were screened for antimicrobial and U2OS bone cancer activities.
  
  
  RESULTS
  4-hydroxycoumarin was derivatized by condensing with different aldehydes yielding the dicoumarol and translactonized products. Elemental analyses, ESI(+,-) MS, 1H and 13C{1H}-NMR, infrared spectroscopy and conductance studies were used to characterize the synthesized compounds which revealed the dicoumarol and dichromone structures for the compounds. The compounds were screened against U2OS cancerous cells and pathogenic micro organisms. The compounds with intermolecular H-bonding were found more active revealing a possible relationship among hydrogen bonding, cytotoxicity and antimicrobial activities.
  
  
  CONCLUSIONS
  Coumarin based drugs can be designed for the possible treatment of U2OS leukemia.
authors.affiliation: Institute of Chemical Sciences, University of Peshawar 25120, Peshawar, Pakistan. sadia_rehman571@yahoo.com.
authors.forename: Sadia
authors.initials: S
authors.lastname: Rehman
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ikram
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Baker
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zubair
authors.forename: Effat
authors.initials: E
authors.lastname: Azad
authors.forename: Soyoung
authors.initials: S
authors.lastname: Min
authors.forename: Kashif
authors.initials: K
authors.lastname: Riaz
authors.forename: Kh
authors.initials: Kh
authors.lastname: Mok
authors.forename: Saeed-Ur
authors.initials: SU
authors.lastname: Rehman