title: An electro-hydrodynamics-based model for the ionic conductivity of solid-state nanopores during DNA translocation.
abstract: A solid-state nanopore can be used to sense DNA (or other macromolecules) by monitoring ion-current changes that result from translocation of the molecule through the pore. When transiting a nanopore, the highly negatively charged DNA interacts with a nanopore both electrically and hydrodynamically, causing a current blockage or a current enhancement at different ion concentrations. This effect was previously characterized using a phenomenological model that can be considered as the limit of the electro-hydrodynamics model presented here. We show theoretically that the effect of surface charge of a nanopore (or electro-osmotic effect) can be equivalently treated as modifications of electrophoretic mobilities of ions in the pore, providing an improved physical understanding of the current blockage (or enhancement).
authors.affiliation: IBM Research, 1101 Kitchawan Road, Yorktown Heights, NY 10598, USA.
authors.forename: Binquan
authors.initials: B
authors.lastname: Luan
authors.forename: Gustavo
authors.initials: G
authors.lastname: Stolovitzky
mesh_terms: D004247:DNA / Q000032:analysis*; D004560:Electricity; D057446:Hydrodynamics; D007477:Ions / Q000737:chemistry*; D008956:Models, Chemical; D058608:Nanopores / Q000648:ultrastructure; D009995:Osmosis; D055672:Static Electricity
chemical_list: D007477:Ions; D004247:DNA