title: Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats.
abstract: OBJECTIVE
  To investigate the antidiabetic property of Merremia emarginata (M. emarginata) Burm. F. plant in streptozotocin induced diabetic rats.
  
  
  METHODS
  The dose dependent effects of 28 days oral treatment with methanol extract (100, 200 and 400 mg/kg) from the plant of M. emarginata on blood glucose level, body weight, insulin, total hemoglobin, glycosylated haemoglobin (HbA1C), total protein, serum urea, serum creatinine and carbohydrate metabolizing enzymes were evaluated in streptozotocin induced diabetic rats. Histology of pancreas was also studied.
  
  
  RESULTS
  A significant decrease in blood glucose, serum urea and serum creatinine and significant increase in body weight, insulin and protein level were observed in diabetic rats treated with M. emarginata. Treatment with M. emarginata resulted in a significant reduction of HbA1C and an increase in total hemoglobin level. The activities of carbohydrate metabolizing enzymes such as hexokinase were significantly increased whereas glucose-6-phosphatase, fructose-1, 6-bisphosphatase were significantly decreased by the administration of M. emarginata in diabetic rats. Histology of diabetic rats treated with M. emarginata showed the pancreatic β-cells regeneration.
  
  
  CONCLUSIONS
  These findings suggest that M. emarginata has potent antidiabetic activity in streptozotocin induced diabetic rats.
authors.affiliation: Division of Ethnopharmacology, Loyola College, Chennai, India-600 034.
authors.forename: G Rajiv
authors.initials: GR
authors.lastname: Gandhi
authors.forename: P
authors.initials: P
authors.lastname: Sasikumar
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D027722:Convolvulaceae / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts
keywords: Antidiabetic effect; Blood glucose; Carbohydrate metabolizing enzymes; Diabetes mellitus; Histology; Insulin; Merremia emarginata; Streptozotocin