title: Childhood trauma, posttraumatic stress disorder, and alcohol dependence.
abstract: Early-childhood trauma is strongly associated with developing mental health problems, including alcohol dependence, later in life. People with early-life trauma may use alcohol to help cope with trauma-related symptoms. This article reviews the prevalence of early-childhood trauma and its robust association with the development of alcohol use disorders and posttraumatic stress disorder. It also examines the potential biological mechanisms by which early adverse experiences can result in long-lasting changes in neurobiology underlying this vulnerability, as well as pharmacological and behavioral interventions. Recent investigations highlight the importance of assessing trauma among patients with alcohol use disorders and the positive benefits associated with the application of integrative psychosocial interventions that target both trauma-related symptoms and alcohol dependence.
authors.affiliation: Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.
authors.forename: Kathleen T
authors.initials: KT
authors.lastname: Brady
authors.forename: Sudie E
authors.initials: SE
authors.lastname: Back
mesh_terms: D000223:Adaptation, Psychological; D054523:Adult Survivors of Child Abuse / Q000523:psychology*; D000427:Alcohol Deterrents / Q000627:therapeutic use; D000437:Alcoholism / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy; D000928:Antidepressive Agents / Q000627:therapeutic use; D001921:Brain / Q000503:physiopathology; D015928:Cognitive Behavioral Therapy; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D020280:Sertraline / Q000627:therapeutic use; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy
chemical_list: D000427:Alcohol Deterrents; D000928:Antidepressive Agents; D020280:Sertraline