title: A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway.
abstract: Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.
authors.affiliation: Division of Pathway Medicine, University of Edinburgh, Chancellor's Building, Little France Crescent, Edinburgh EH16 4SB, Scotland, UK. a.mazein@oist.jp
authors.forename: Alexander
authors.initials: A
authors.lastname: Mazein
authors.forename: Steven
authors.initials: S
authors.lastname: Watterson
authors.forename: Wei-Yuan
authors.initials: WY
authors.lastname: Hsieh
authors.forename: William J
authors.initials: WJ
authors.lastname: Griffiths
authors.forename: Peter
authors.initials: P
authors.lastname: Ghazal
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000031:analogs & derivatives / Q000096:biosynthesis*; D003196:Computer Graphics; D001330:Electronic Data Processing; D006801:Humans; D020407:Internet; D008322:Mammals; D053858:Metabolic Networks and Pathways; D008798:Mevalonic Acid / Q000378:metabolism; D008954:Models, Biological; D012984:Software; D013185:Squalene / Q000378:metabolism; D049490:Systems Biology
chemical_list: C028358:24,25-epoxycholesterol; D013185:Squalene; D002784:Cholesterol; D008798:Mevalonic Acid