title: [Par polarity complex in mammalian neurogenesis].
abstract: Mammalian neurogenesis is a highly complicated process with programmed morphology and function evolution. Polarity, a basic characteristic in neurogenesis, is controlled by regulating proteins such as the partition defective (Par) proteins. Par polarity complex is the most investigated Par protein among these polarity proteins. There are developmental dynamic changes during neurogenesis for the protein distribution and content, which are related to the junction establishment, polarity formation, synaptogenesis, and neuronal migration. Moreover, Par complex is considered to affect the developmental fate of neural precursors. This study summarizes the advances of the protein cellular location, function, and mechanism in embryal neocortex and cultured neuron.
authors.affiliation: College of Biological and Environment Engineering, Zhejiang University of Technology, Hangzhou, China. chenhuiling1010@163.com
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Chen
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Chen
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism*; D016764:Cell Polarity / Q000502:physiology*; D006801:Humans; D008322:Mammals / Q000196:embryology / Q000502:physiology; D046912:Multiprotein Complexes / Q000235:genetics* / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; D046912:Multiprotein Complexes