title: MicroRNA-22 is down-regulated in hepatitis B virus-related hepatocellular carcinoma.
abstract: MicroRNAs (miRNAs) are a new class of short noncoding RNAs with post-transcriptional regulation and participate in diverse physiological and pathological processes. MiR-22, ubiquitously expressed in various tissues, plays a functional important role in life processes and is recently proved to involve in many cancers. In present study, we had shown that miR-22 was down-regulated much more obviously in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) cell lines as well as in clinical tissues. Cyclin-dependent kinase inhibitor 1A (CDKN1A) was found to be inversely correlated with miR-22 and was identified as a target of miR-22. Overexpression of miR-22 in vitro effectively suppressed CDKN1A expression and inhibited cell proliferation. We conclude that miR-29c may play an important role as a tumor suppressive microRNA in the development and progression of HBV-related HCC by targeting CDKN1A.
authors.affiliation: Shandong Jining NO.1 People's Hospital, Jining, PR China.
authors.forename: Cailing
authors.initials: C
authors.lastname: Shi
authors.forename: Xudong
authors.initials: X
authors.lastname: Xu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology / Q000821:virology; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D018450:Disease Progression; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D056945:Hep G2 Cells; D006509:Hepatitis B / Q000150:complications; D006515:Hepatitis B virus / Q000302:isolation & purification; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology / Q000821:virology; D035683:MicroRNAs / Q000235:genetics*
chemical_list: C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; C548375:MIRN22 microRNA, human; D035683:MicroRNAs