title: Hepatoprotective effect of acetone semicarbazone on Ehrlich ascites carcinoma induced carcinogenesis in experimental mice.
abstract: OBJECTIVE
  To determine the hepatoprotective effect of acetone semicarbazone (ASC) in vivo in normal and Ehrlich ascites carcinoma (EAC) bearing male Swiss albino mice.
  
  
  METHODS
  Drug-induced changes in biochemical and behavioral parameters at dose of 2.0 mg/kg body weight for 14 d and nullifying the toxicity induced by EAC cells were studied. The histopathology studies of the protective effects of ASC on vital organs were also assessed.
  
  
  RESULTS
  The administration of ASC made insignificant changes in body weight and behavioral (salivation, diarrhea, muscular numbness) changes during treatment period due to minor toxicity were minimized after the treatment in normal mice. The biochemical parameters, including serum glutamate pyruvate transaminase, glutamate oxaloactate transaminase, alkaline phosphatase, serum glucose, cholesterol, urea, triglyceride and billirubin changed modestly in normal mice receiving ASC. Though the treatment continued, these values gradually decreased to normal level after the treatment. In EAC bearing mice, the toxic effects due to EAC cells in all cases were nullified by treatment with the ASC. Significant abnormalities were not detected in histology of the various organs of the normal mice treated with ASC.
  
  
  CONCLUSIONS
  ASC can, therefore, be considered safe in formulating novel anticancer drug, as it exhibits strong protective effect against EAC cell bearing mice.
authors.affiliation: Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi 6205, Bangladesh.
authors.forename: Farhadul
authors.initials: F
authors.lastname: Islam
authors.forename: Shaikh Mohummad Mohsin
authors.initials: SM
authors.lastname: Ali
authors.forename: Jahan Ara
authors.initials: JA
authors.lastname: Khanam
mesh_terms: D000096:Acetone / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D063646:Carcinogenesis / Q000187:drug effects*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D012664:Semicarbazones / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D012664:Semicarbazones; D000096:Acetone
keywords: Acetone semicarbazone; EAC cell; Histopathology; Host toxicity; Schiff bases; Subacute toxicity