title: High syndecan-1 levels in acute myeloid leukemia are associated with bleeding, thrombocytopathy, endothelial cell damage, and leukocytosis.
abstract: The risk of hemorrhage is influenced by multiple factors in acute myeloid leukemia (AML). We investigated whether hemorrhage in AML patients was associated with endothelial perturbation, potentially caused by thrombocytopenia, platelet dysfunction and leukocytosis. Biomarkers of endothelial perturbation, coagulation and platelet activation were analyzed in 49 AML patients, along with previously collected data on bleeding status and platelet activation markers. High levels of syndecan-1, a marker of endothelial glycocalyx degradation, were associated with bleeding, impaired platelet function, higher age, endothelial cell activation and damage, and leukocytosis. We suggest that platelet dysfunction and leukocytosis in AML causes endothelial perturbation.
authors.affiliation: Department of Hematology, Herlev University Hospital, Herlev, Denmark. anm.larsen@gmail.com
authors.forename: Anne Mette
authors.initials: AM
authors.lastname: Larsen
authors.forename: Eva Birgitte
authors.initials: EB
authors.lastname: Leinøe
authors.forename: Pär I
authors.initials: PI
authors.lastname: Johansson
authors.forename: Henrik
authors.initials: H
authors.lastname: Birgens
authors.forename: Sisse R
authors.initials: SR
authors.lastname: Ostrowski
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis*; D001777:Blood Coagulation; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006470:Hemorrhage / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000378:metabolism; D007964:Leukocytosis / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D053668:Syndecan-1 / Q000378:metabolism*; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism
chemical_list: D015415:Biomarkers; D053668:Syndecan-1