title: Trianion synthon approach to spirocyclic heterocycles.
abstract: A variety of spirocyclic heterocycles have been constructed by a double-alkylation and reductive cyclization approach utilizing α-heteroatom nitriles as trianion synthons. The method provides access to heteroatom-substituted spirocycles in a variety of ring sizes that are found in natural products and are important in pharmaceutical lead development and optimization.
authors.affiliation: Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, Irvine, California 92697, United States.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Perry
authors.forename: Richard R
authors.initials: RR
authors.lastname: Hill
authors.forename: Scott D
authors.initials: SD
authors.lastname: Rychnovsky
mesh_terms: D000478:Alkylation; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D013141:Spiro Compounds