title: Genome comparisons as a tool for antimicrobial target discovery.
abstract: Essential genes are frequently conserved among bacterial species and thus microbial and eukaryote genome comparisons can be used to compile datasets of homologous proteins and families that can be utilized to identify attractive targets for the design of antimicrobial agents and other drugs. These searches can now often be conducted using Web tools. A number of such resources that provide sequence information and comparative software as well as computational tools for convenient analysis of the data are summarized here and their step-by-step use explained.
authors.affiliation: Shanghai Center for Bioinformation Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Sun
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Chen
authors.forename: Runsheng
authors.initials: R
authors.lastname: Chen
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods*; D023281:Genomics / Q000379:methods*; D020407:Internet; D008958:Models, Molecular; D011487:Protein Conformation; D012984:Software
chemical_list: D000890:Anti-Infective Agents; D001426:Bacterial Proteins