title: Identification of a pegivirus (GB virus-like virus) that infects horses.
abstract: The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.
authors.affiliation: Center for Infection and Immunity, Columbia University, New York, New York, USA. ak3117@columbia.edu
authors.forename: Amit
authors.initials: A
authors.lastname: Kapoor
authors.forename: Peter
authors.initials: P
authors.lastname: Simmonds
authors.forename: John M
authors.initials: JM
authors.lastname: Cullen
authors.forename: Troels K H
authors.initials: TK
authors.lastname: Scheel
authors.forename: Jan L
authors.initials: JL
authors.lastname: Medina
authors.forename: Federico
authors.initials: F
authors.lastname: Giannitti
authors.forename: Eiko
authors.initials: E
authors.lastname: Nishiuchi
authors.forename: Kenny V
authors.initials: KV
authors.lastname: Brock
authors.forename: Peter D
authors.initials: PD
authors.lastname: Burbelo
authors.forename: Charles M
authors.initials: CM
authors.lastname: Rice
authors.forename: W Ian
authors.initials: WI
authors.lastname: Lipkin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018067:Flaviviridae / Q000145:classification* / Q000235:genetics; D018178:Flaviviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D006734:Horse Diseases / Q000453:epidemiology / Q000821:virology*; D006736:Horses / Q000821:virology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D015995:Prevalence; D017422:Sequence Analysis, DNA; D013045:Species Specificity; D014481:United States / Q000453:epidemiology; D014766:Viremia / Q000453:epidemiology / Q000821:virology