title: Comparison of MICs of fluconazole and flucytosine when dissolved in dimethyl sulfoxide or water.
abstract: A total of 145 clinical strains of Candida species were tested by the Clinical and Laboratory Standards Institute M27-A3 methodology to determine if replacing water with dimethyl sulfoxide as the solvent for fluconazole and flucytosine impacted the in vitro potency. No significant differences in MIC values were observed with either antifungal between the two solvents against any Candida species, and the essential agreement for each agent between the two solvents was greater than 99%.
authors.affiliation: Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
authors.forename: Annette W
authors.initials: AW
authors.lastname: Fothergill
authors.forename: Carmita
authors.initials: C
authors.lastname: Sanders
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Wiederhold
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D015725:Fluconazole / Q000737:chemistry / Q000494:pharmacology*; D005437:Flucytosine / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D012997:Solvents / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D012997:Solvents; D014867:Water; D015725:Fluconazole; D005437:Flucytosine; D004121:Dimethyl Sulfoxide