title: Effects of mechano-electric feedback on scroll wave stability in human ventricular fibrillation.
abstract: Recruitment of stretch-activated channels, one of the mechanisms of mechano-electric feedback, has been shown to influence the stability of scroll waves, the waves that underlie reentrant arrhythmias. However, a comprehensive study to examine the effects of recruitment of stretch-activated channels with different reversal potentials and conductances on scroll wave stability has not been undertaken; the mechanisms by which stretch-activated channel opening alters scroll wave stability are also not well understood. The goals of this study were to test the hypothesis that recruitment of stretch-activated channels affects scroll wave stability differently depending on stretch-activated channel reversal potential and channel conductance, and to uncover the relevant mechanisms underlying the observed behaviors. We developed a strongly-coupled model of human ventricular electromechanics that incorporated human ventricular geometry and fiber and sheet orientation reconstructed from MR and diffusion tensor MR images. Since a wide variety of reversal potentials and channel conductances have been reported for stretch-activated channels, two reversal potentials, -60 mV and -10 mV, and a range of channel conductances (0 to 0.07 mS/µF) were implemented. Opening of stretch-activated channels with a reversal potential of -60 mV diminished scroll wave breakup for all values of conductances by flattening heterogeneously the action potential duration restitution curve. Opening of stretch-activated channels with a reversal potential of -10 mV inhibited partially scroll wave breakup at low conductance values (from 0.02 to 0.04 mS/µF) by flattening heterogeneously the conduction velocity restitution relation. For large conductance values (>0.05 mS/µF), recruitment of stretch-activated channels with a reversal potential of -10 mV did not reduce the likelihood of scroll wave breakup because Na channel inactivation in regions of large stretch led to conduction block, which counteracted the increased scroll wave stability due to an overall flatter conduction velocity restitution.
authors.affiliation: Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America.
authors.forename: Yuxuan
authors.initials: Y
authors.lastname: Hu
authors.forename: Viatcheslav
authors.initials: V
authors.lastname: Gurev
authors.forename: Jason
authors.initials: J
authors.lastname: Constantino
authors.forename: Jason D
authors.initials: JD
authors.lastname: Bayer
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Trayanova
mesh_terms: D025461:Feedback, Physiological; D006329:Heart Conduction System / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D015640:Ion Channel Gating; D008465:Mechanoreceptors / Q000502:physiology; D008564:Membrane Potentials; D008954:Models, Biological; D009200:Myocardial Contraction; D014693:Ventricular Fibrillation / Q000503:physiopathology*