title: Protective effect of aqueous extract of Feronia elephantum correa leaves on thioacetamide induced liver necrosis in diabetic rats.
abstract: OBJECTIVE
  To evalueate hepatoprotective effects Feronia elephantum (F. elephantum) correa against thioacetamide (TA) induced liver necrosis in diabetic rats.
  
  
  METHODS
  Male wistar rats were made diabetic with alloxan (160 mg/kg) on day 0 of the study. They were intoxicated with hepatotoxicant (thioacetamide, 300 mg/kg, ip) on day 9 of study to produce liver necrosis. Effects of 7 day daily once administration (day 2 to day 9) of EF (400 and 800 mg/kg, po) were evaluated on necorosis of liver in terms of mortality, liver volume, liver weight, serum aspartate aminotransferase (AST) and serum alanine transaminase (ALT), and histopathology of liver sections (for signs of necorosis and inflammation) on day-9 of the study. Separate groups of rats with treated only with alloxan (DA control), thioacetamide (TA control) and both (TA+DA control) were maintained.
  
  
  RESULTS
  FE significantly lowered the mortality rate and showed improvement in liver function parameters in TA-induced diabetic rats without change in liver weight, volume and serum glucose levels.
  
  
  CONCLUSIONS
  FE showed promising activity against TA-induced liver necorsis in diabetic rats and so might be useful for prevention of liver complications in DM.
authors.affiliation: Department of Pharmacology, Poona College of Pharmacy, Bharati Deemed Vidyapeeth University, Erandwane, Pune-411038, India.
authors.forename: Prashant
authors.initials: P
authors.lastname: Sharma
authors.forename: Subhash L
authors.initials: SL
authors.lastname: Bodhankar
authors.forename: Prasad A
authors.initials: PA
authors.lastname: Thakurdesai
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology* / Q000517:prevention & control; D003921:Diabetes Mellitus, Experimental; D004195:Disease Models, Animal; D008111:Liver Function Tests; D008297:Male; D009336:Necrosis; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D020011:Protective Agents; D051381:Rats; D027821:Rutaceae / Q000737:chemistry*; D013853:Thioacetamide / Q000009:adverse effects
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts; D020011:Protective Agents; D013853:Thioacetamide
keywords: Diabetes mellitus; Feronia elephantum correa; Hepatic necrosis; Thioacetamide