title: Sildenafil and cardioprotection.
abstract: The phosphodiesterese-5 (PDE5) inhibitors, including sildenafil (Viagra™), vardenafil (Levitra™), tadalafil (Cialis™) and avanafil (Stendra™) have been developed for the treatment of erectile dysfunction. Moreover, sildenafil and tadalafil have been approved for the management of pulmonary arterial hypertension. A number of preclinical studies have shown that PDE5 inhibitors have powerful protective effect against several clinical scenarios including myocardial ischemia/reperfusion injury, doxorubicin and post-MI, heart failure, cardiac hypertrophy, heart transplantation, Duchenne muscular dystrophy and preconditioning of stem cells. Based on these studies, it appears that sildenafil and other PDE5 inhibitors hold promise for further development as novel drug therapies in cardioprotection.
authors.affiliation: Scientific Director, Pauley Heart Center, Professor of Medicine, Physiology, Biochemistry, and Emergency Medicine, Eric Lipman Professor of Cardiology, Division of Cardiology, Box 980204, Virginia Commonwealth University, 1101 East Marshall Street, Room 7-020D, Richmond, VA 23298, USA. rakesh@vcu.edu.
authors.forename: Rakesh C
authors.initials: RC
authors.lastname: Kukreja
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004317:Doxorubicin / Q000633:toxicity; D006321:Heart / Q000187:drug effects; D016027:Heart Transplantation; D020388:Muscular Dystrophy, Duchenne / Q000503:physiopathology; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines / Q000627:therapeutic use; D011817:Rabbits; D015427:Reperfusion Injury / Q000517:prevention & control; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*
chemical_list: D002316:Cardiotonic Agents; D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D004317:Doxorubicin; D000068677:Sildenafil Citrate