title: The IGFBP7 homolog Imp-L2 promotes insulin signaling in distinct neurons of the Drosophila brain.
abstract: In Drosophila, Insulin-like peptide 2 (Dilp-2) is expressed by insulin-producing cells in the brain, and is secreted into the hemolymph to activate insulin signaling systemically. Within the brain, however, a more local activation of insulin signaling may be required to couple behavioral and physiological traits to nutritional inputs. We show that a small subset of neurons in the larval brain has high Dilp-2-mediated insulin signaling activity. This local insulin signaling activation is accompanied by selective Dilp-2 uptake and depends on the expression of the Imaginal morphogenesis protein-late 2 (Imp-L2) in the target neurons. We suggest that Imp-L2 acts as a licensing factor for neuronal IIS activation through Dilp-2 to further increase the precision of insulin activity in the brain.
authors.affiliation: LIMES Life and Medical Sciences, Laboratory of Molecular Brain Physiology and Behavior, University of Bonn, Bonn 53115, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Bader
authors.forename: L
authors.initials: L
authors.lastname: Sarraf-Zadeh
authors.forename: M
authors.initials: M
authors.lastname: Peters
authors.forename: N
authors.initials: N
authors.lastname: Moderau
authors.forename: H
authors.initials: H
authors.lastname: Stocker
authors.forename: K
authors.initials: K
authors.lastname: Köhler
authors.forename: M J
authors.initials: MJ
authors.lastname: Pankratz
authors.forename: E
authors.initials: E
authors.lastname: Hafen
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism*; D007814:Larva / Q000378:metabolism; D009024:Morphogenesis / Q000502:physiology; D009474:Neurons / Q000378:metabolism*; D011485:Protein Binding; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D029721:Drosophila Proteins; D007328:Insulin; D018969:Insulin-Like Growth Factor Binding Proteins
keywords: Brain; Drosophila; Imp-L2; Insulin signaling