title: The V-shaped ligand bis(N-allylbenzimidazol-2-ylmethyl)benzylamine and its Ag(I) complex: synthesis, crystal structure, DNA-binding properties and antioxidation.
abstract: A novel dinuclear Ag(I) complex of the type, [Ag2L2](pic)2, was synthesized by the reaction of the V-shaped ligand bis(N-allylbenzimidazol-2-ylmethyl)benzylamine (L) with Ag(pic) (pic=picrate). Ligand L and Ag(I) complex were characterized on the basis of elemental analysis, UV-vis, IR, NMR spectroscopy and X-ray crystallography. Single-crystal X-ray revealed that two L coordinated to a central silver(I) cation in a near-linear fashion through their benzimidazol-1-yl nitrogen atoms, and a centrosymmetric dinuclear pore canal structure was constructed in the discrete [Ag2L(2)2](2+) cation. The DNA-binding properties of the free ligand L and Ag(I) complex have been carried out by using electronic absorption, fluorescence, and viscosity measurements. The results support that ligand L and Ag(I) complex both bind to DNA via an intercalative binding mode, and the affinity for DNA is more strongly in case of Ag(I) complex when compared with ligand L. Moreover, Ag(I) complex also exhibited potential antioxidant properties in vitro studies.
authors.affiliation: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, PR China. wuhuilu@163.com
authors.forename: Huilu
authors.initials: H
authors.lastname: Wu
authors.forename: Jingkun
authors.initials: J
authors.lastname: Yuan
authors.forename: Guolong
authors.initials: G
authors.lastname: Pan
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wang
authors.forename: Furong
authors.initials: F
authors.lastname: Shi
authors.forename: Xuyang
authors.initials: X
authors.lastname: Fan
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D001596:Benzylamines / Q000138:chemical synthesis / Q000737:chemistry*; D001667:Binding, Competitive; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012834:Silver / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001562:Benzimidazoles; D001596:Benzylamines; D056831:Coordination Complexes; D008024:Ligands; D009942:Organometallic Compounds; C584648:bis(bis(N-allylbenzimidazol-2-ylmethyl)benzylamine)silver(I); D012834:Silver; D004247:DNA