title: On the problem of identification of intracellular signaling pathways.
abstract: A hypothesis is proposed about the involvement of mitochondria in transduction of intracellular signals. In addition to the endoplasmic reticulum responsible for fluctuations of intracellular concentration of Ca2+, mitochondria are supposed to determine changes in the concentration of the secondary messenger cAMP. This hypothesis extends our ideas concerning mechanisms of intracellular signal transduction.
authors.affiliation: All-Russian Research Institute of Farm Animal Genetics and Breeding, Russian Academy of Agricultural Sciences, St. Petersburg, 196600, Russia.
authors.forename: V Yu
authors.initials: VY
authors.lastname: Denisenko
authors.forename: T I
authors.initials: TI
authors.lastname: Kuzmina
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000096:biosynthesis / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005057:Eukaryotic Cells / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism*; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000242:Cyclic AMP; D002118:Calcium