title: Chloral hydrate and/or hydroxyzine for sedation in pediatric EEG recording.
abstract: OBJECTIVE
  To evaluate and compare the success of chloral hydrate (CH) and hydroxyzine on sedation and assess the changes of these drugs on sleep EEG recordings.
  
  
  METHODS
  Three hundred and forty-one patients (mean age: 60.92±53.81months) that were uncooperative with the EEG setup or referred for sleep EEG were enrolled in the study. Patients, partially sleep-deprived the night before, were firstly tried to fall on sleep without any medication, the patients who could not sleep spontaneously were randomly divided in two groups of hydroxyzine and chloral hydrate.
  
  
  RESULTS
  In 147 (43%) of cases, CH was given for sedation. In 112 (32%) hydroxyzine and in 8% of cases CH and hydroxyzine were given. 17% of children had spontaneous sleep. The doses of drugs prescribed were as follows: hydroxyzine 1.43±0.74mg/kg CH 38±14.73mg/kg. The time to go on a sleep was 34.68±30.75min in hydroxyzine and 32.34±26.83min in CH group (p>0.05). Eighty-nine percent of cases who were sedated with CH and 89.6% of cases who sedated with hydroxyzine were able to sleep (p>0.05). The background rhythm was faster with CH compared to hydroxyzine (p<0.05). There were no association between the occurrence of fast background rhythm and the doses of CH.
  
  
  CONCLUSIONS
  The study described the clinical practice of sedation with CH and hydroxyzine on EEG recording. Data suggest that CH with low doses and hydroxyzine is equally effective for sleep induction, but the side effects of CH on the sleep EEG is much more prominent.
authors.affiliation: Department of Pediatric Neurology, School of Medicine, Ankara University, Ankara, Turkey. Electronic address: bektasomer@gmail.com.
authors.forename: Omer
authors.initials: O
authors.lastname: Bektas
authors.affiliation: Department of Adult Neurology, School of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Büsra
authors.initials: B
authors.lastname: Arıca
authors.affiliation: Department of Pediatric Neurology, School of Medicine, Ankara University, Ankara, Turkey. Electronic address: seraptteber@gmail.com.
authors.forename: Serap
authors.initials: S
authors.lastname: Teber
authors.affiliation: Department of Pediatric Neurology, School of Medicine, Ankara University, Ankara, Turkey. Electronic address: arzuotken@yahoo.com.
authors.forename: Arzu
authors.initials: A
authors.lastname: Yılmaz
authors.affiliation: Department of Pediatric Neurology, School of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Hediye
authors.initials: H
authors.lastname: Zeybek
authors.affiliation: Department of Pediatric Neurology, School of Medicine, Ankara University, Ankara, Turkey. Electronic address: s-kaymak@hotmail.com.
authors.forename: Selda
authors.initials: S
authors.lastname: Kaymak
authors.affiliation: Department of Pediatric Neurology, School of Medicine, Ankara University, Ankara, Turkey. Electronic address: gulhisdeda@hotmail.com.
authors.forename: Gülhis
authors.initials: G
authors.lastname: Deda
mesh_terms: D000293:Adolescent; D002648:Child; D002652:Child Behavior / Q000187:drug effects*; D002675:Child, Preschool; D002697:Chloral Hydrate / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D006919:Hydroxyzine / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D012890:Sleep / Q000187:drug effects*
chemical_list: D006993:Hypnotics and Sedatives; D006919:Hydroxyzine; D002697:Chloral Hydrate
keywords: Chloral hydrate; Hydroxyzine; Sedation; Sleep EEG