title: Effects of dietary high fat on prostate intraepithelial neoplasia in TRAMP mice.
abstract: Increased fat intake is known to be a major cause of prostate cancer. In this study, we investigated the effect of dietary high fat on prostate intraepithelial neoplasia using transgenic adenocarcinoma mouse prostate (TRAMP) mice. Six-week-old male TRAMP mice were fed AIN93G (control group, 4.0 kcal/kg, n=6) and AIN93G-HFD (experimental group, 4.8 kcal/kg, n=7) for 10 weeks. Prostate histopathology, urogenital tract (UGT) weight, epididymal white adipose tissue weight, argyrophilic nucleolar organizer regions (AgNORs) counts, and serum leptin levels were examined. AIN93G-HFD fed group showed progressed neoplastic lesions in the prostate (P<0.05) compared to AIN93G fed group. AIN93G-HFD intake resulted in a increase in the weight of UGT (P<0.05) and epididymal white adipose tissue. The number of Ag-NOR positive dots significantly increased in each prostate lobe and final serum leptin levels in AIN93G-HFD fed group were about twice those of AIN93G fed group (P<0.05). Dietary high fat was related to the prostate cancer progression in the early stage of TRAMP mice and increased serum leptin levels, suggesting that the regulation of dietary components could delay the progression of prostate cancer.
authors.affiliation: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Park
authors.forename: Seo-Na
authors.initials: SN
authors.lastname: Chang
authors.forename: Min-Won
authors.initials: MW
authors.lastname: Baek
authors.forename: Dong-Jae
authors.initials: DJ
authors.lastname: Kim
authors.forename: Yi-Rang
authors.initials: YR
authors.lastname: Na
authors.forename: Seung-Hyeok
authors.initials: SH
authors.lastname: Seok
authors.forename: Byoung-Hee
authors.initials: BH
authors.lastname: Lee
authors.forename: Kyung-Sul
authors.initials: KS
authors.lastname: Kim
authors.forename: Jae-Hak
authors.initials: JH
authors.lastname: Park
keywords: Ag-NOR; High fat; early progression; prostate cancer; transgenic adenocarcinoma mouse prostate