title: Progress in understanding the genetics of bronchopulmonary dysplasia.
abstract: Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants. Its treatment imposes considerable healthcare burden and costs in the perinatal and early childhood period and patients are usually left with lifelong deficits in lung function. Evidence exists for different pathophysiologic pathways that can promote the structural changes that characterize BPD, including the impairment in alveolarization; however, there is increasing interest regarding heritable factors that may predispose very low birth weight infants to BPD. Our review focuses on recent publications that have investigated genetic factors that may potentially contribute to such reported heritability. These publications point us toward some possible genomic candidates for further study, but certainly do not identify any particular gene or gene pathway that would be inferred to be contributing substantially to the underlying etiology of BPD.
authors.affiliation: Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
authors.forename: Gary M
authors.initials: GM
authors.lastname: Shaw
authors.forename: Hugh M
authors.initials: HM
authors.lastname: O'Brodovich
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D020641:Polymorphism, Single Nucleotide