title: Glycogen synthase kinase 3 alpha phosphorylates and regulates the osteogenic activity of Osterix.
abstract: Osteoblast-specific transcription factor Osterix is a zinc-finger transcription factor that required for osteoblast differentiation and new bone formation. The function of Osterix can be modulated by post-translational modification. Glycogen synthase kinase 3 alpha (GSK3α) is a multifunctional serine/threonine protein kinase that plays a role in the Wnt signaling pathways and is implicated in the control of several regulatory proteins and transcription factors. In the present study, we investigated how GSK3α regulates Osterix during osteoblast differentiation. Wide type GSK3α up-regulated the protein level, protein stability and transcriptional activity of Osterix. These results suggest that GSK3α regulates osteogenic activity of Osterix.
authors.affiliation: College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, Republic of Korea.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Li
authors.forename: Hyung Min
authors.initials: HM
authors.lastname: Jeong
authors.forename: You Hee
authors.initials: YH
authors.lastname: Choi
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Hye Gwang
authors.initials: HG
authors.lastname: Jeong
authors.forename: Tae Cheon
authors.initials: TC
authors.lastname: Jeong
authors.forename: Kwang Youl
authors.initials: KY
authors.lastname: Lee
mesh_terms: D000818:Animals; D017930:Genes, Reporter; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism*; D008156:Luciferases / Q000235:genetics; D051379:Mice; D016297:Mutagenesis, Site-Directed; D010766:Phosphorylation; D000076182:Sp7 Transcription Factor; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology
chemical_list: D000076182:Sp7 Transcription Factor; C479466:Sp7 protein, mouse; D014157:Transcription Factors; D008156:Luciferases; D038362:Glycogen Synthase Kinase 3; C448021:glycogen synthase kinase 3 alpha