title: Relationship between cerebral microbleeds and cognitive function in lacunar infarct.
abstract: OBJECTIVE
  Little is known about the impact of cerebral microbleeds on cognitive function. This study investigated the distribution of cerebral microbleeds and their impact on cognitive function, in patients with lacunar infarct.
  
  
  METHODS
  Patients with lacunar infarct were enrolled prospectively. Cerebral microbleeds were classified as absent, mild, moderate or severe, based on magnetic resonance imaging findings. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) questionnaire, with a total score of <26 indicating cognitive impairment.
  
  
  RESULTS
  Of the 85 patients included in the study, 35 (41.2%) had cerebral microbleeds. They were more frequently observed in mixed and deep brain regions, but rarely in the cerebral lobes. Multiple logistic regression analysis demonstrated that presence of cerebral microbleeds (odds ratio [OR] 5.320), duration of education (OR 0.938) and age (OR 1.464) were independent predictors of cognitive impairment. There was a significant correlation between cerebral microbleed severity and MoCA score.
  
  
  CONCLUSIONS
  The number and location of cerebral microbleeds were both closely associated with cognitive impairment, in patients with lacunar infarct.
authors.affiliation: Department of Neurology, The Second People's Hospital of Changzhou Affiliated to Nanjing Medical University, Changzhou, Jiangsu, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Maogang
authors.initials: M
authors.lastname: Chen
authors.forename: Qizhang
authors.initials: Q
authors.lastname: Wang
authors.forename: Wenwei
authors.initials: W
authors.lastname: Yun
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Qin
authors.initials: Q
authors.lastname: Yin
authors.forename: Qinsong
authors.initials: Q
authors.lastname: Huang
authors.forename: Wusheng
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000368:Aged; D044466:Asian People; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D002681:China; D003071:Cognition / Q000502:physiology*; D003710:Demography; D005260:Female; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D059409:Stroke, Lacunar / Q000150:complications* / Q000503:physiopathology*
keywords: Cerebral microbleed; cognition; ischaemic stroke; lacunar infarct