title: Bilateral atypical optic neuritis associated with tuberculosis in an immunocompromised patient.
abstract: A 27 year-old lady, presented with sudden loss of vision in the right eye for a week. It was followed by poor vision in the left eye after 3 days. It involved the whole entire visual field and was associated with pain on eye movement. She was diagnosed to have miliary tuberculosis and retroviral disease 4 months ago. She was started on anti-TB since then but defaulted highly active anti-retroviral therapy (HAART). On examination, her visual acuity was no perception of light in the right eye and 6/120 (pinhole 3/60) in the left eye. Anterior segment in both eyes was unremarkable. Funduscopy showed bilateral optic disc swelling with presence of multiple foci of choroiditis in the peripheral retina. The vitreous and retinal vessels were normal. Chest radiography was normal. CT scan of orbit and brain revealed bilateral enhancement of the optic nerve sheath that suggest the diagnosis of bilateral atypical optic neuritis. This patient was managed with infectious disease team. She was started on HAART and anti-TB treatment was continued. She completed anti-TB treatment after 9 months without any serious side effects. During follow up the visual acuity in both eyes was not improved. However, funduscopy showed resolving of disc swelling and choroiditis following treatment.
authors.affiliation: Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
authors.forename: Juanarita
authors.initials: J
authors.lastname: Jaafar
authors.forename: Wan Hazabbah Wan
authors.initials: WH
authors.lastname: Hitam
authors.forename: Raja Azmi Mohd
authors.initials: RA
authors.lastname: Noor
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D005123:Eye / Q000473:pathology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006257:Head / Q000000981:diagnostic imaging; D006801:Humans; D016867:Immunocompromised Host; D019721:Ophthalmoscopes; D009900:Optic Nerve / Q000473:pathology; D009902:Optic Neuritis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*
chemical_list: D044966:Anti-Retroviral Agents; D000995:Antitubercular Agents
keywords: Funduscopy; Optic neuritis; Tuberculosis