title: Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model?
abstract: This article reviews the strengths and limitations of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) as models of cardiac arrhythmias. Specifically, the article attempts to answer the following questions: Which clinical arrhythmias can be modeled by iPSC-CM? How well can iPSC-CM model adult ventricular myocytes? What are the strengths and limitations of published iPSC-CM arrhythmia models? What new mechanistic insight has been gained? What is the evidence that would support using iPSC-CM to personalize antiarrhythmic drug therapy? The review also discusses the pros and cons of using the iPSC-CM technology for modeling specific genetic arrhythmia disorders, such as long QT syndrome, Brugada Syndrome, or Catecholaminergic Polymorphic Ventricular Tachycardia.
authors.affiliation: Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232-0575, USA. bjorn.knollmann@vanderbilt.edu
authors.forename: Björn C
authors.initials: BC
authors.lastname: Knollmann
mesh_terms: D001145:Arrhythmias, Cardiac / Q000473:pathology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D032383:Myocytes, Cardiac / Q000166:cytology*