title: Exploring coronary atherosclerosis with intravascular imaging.
abstract: Coronary angiography has been widely used for five decades to evaluate a range of vascular pathologies and triage patients to therapeutic interventions. The inability to directly visualize the artery wall with conventional angiographic techniques has stimulated development of a number of intravascular imaging modalities. These approaches have the potential to provide a more comprehensive characterization of the burden, composition and functionality of atherosclerotic plaque, neointimal hyperplasia and allograft vasculopathy that develop within coronary arteries. The ability to use these modalities in vivo and in a serial fashion has provided a greater insight into the factors that underlie the disease process and guide therapeutic interventions.
authors.affiliation: Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, OH, USA.
authors.forename: Rishi
authors.initials: R
authors.lastname: Puri
authors.forename: E Murat
authors.initials: EM
authors.lastname: Tuzcu
authors.forename: Steven E
authors.initials: SE
authors.lastname: Nissen
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Nicholls
mesh_terms: D000818:Animals; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D006801:Humans; D058426:Neointima / Q000000981:diagnostic imaging; D041623:Tomography, Optical Coherence / Q000379:methods; D018084:Ultrasonography, Interventional / Q000379:methods
keywords: Allograft vasculopathy; Atherosclerosis; Coronary artery disease; IBIS; Imaging; MAIN-COMPARE; Neointimal hyperplasia; PREDICTION; PROSPECT; Risk factors; integrated biomarker and imaging study; prediction of progression of coronary artery disease using vascular profiling of shear stress and wall morphology; providing regional observations to study predictors of events in the coronary tree; revascularization for unprotected left main coronary artery stenosis: comparison of percutaneous coronary angioplasty vs. surgical revascularization