title: MULTIPLE TESTING OF LOCAL MAXIMA FOR DETECTION OF PEAKS IN 1D.
abstract: A topological multiple testing scheme for one-dimensional domains is proposed where, rather than testing every spatial or temporal location for the presence of a signal, tests are performed only at the local maxima of the smoothed observed sequence. Assuming unimodal true peaks with finite support and Gaussian stationary ergodic noise, it is shown that the algorithm with Bonferroni or Benjamini-Hochberg correction provides asymptotic strong control of the family wise error rate and false discovery rate, and is power consistent, as the search space and the signal strength get large, where the search space may grow exponentially faster than the signal strength. Simulations show that error levels are maintained for nonasymptotic conditions, and that power is maximized when the smoothing kernel is close in shape and bandwidth to the signal peaks, akin to the matched filter theorem in signal processing. The methods are illustrated in an analysis of electrical recordings of neuronal cell activity.
authors.affiliation: Department of Biostatistics, Harvard School of Public Health and Dana-Farber Cancer Institute, 450 Brookline Ave., CLS 11007, Boston, Massachusetts 02446, USA.
authors.forename: Armin
authors.initials: A
authors.lastname: Schwartzman
authors.forename: Yulia
authors.initials: Y
authors.lastname: Gavrilov
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Adler
keywords: False discovery rate; Gaussian process; kernel smoothing; matched filter; topological inference