title: High expression of KIF26B in breast cancer associates with poor prognosis.
abstract: To date, a great number of studies have demonstrated that altered expression of kinesins is associated with development and progression of various human cancers. Kinesin family member 26B (KIF26B), a member of the kinesin superfamily proteins (KIFs), is essential for kidney development. However, the role of KIF26B during tumorigenesis and progression is limited. Here, we demonstrate that both KIF26B mRNA and protein are overexpression in breast cancer tissues by RT-qPCR and western blot. Immunohistochemistry revealed that KIF26B expression significantly correlated with clinicopathological factors, including tumor size (P = 0.011), grade (P = 0.017), lymph node status (P = 0.009) and ER status (P = 0.012). Moreover, the Kaplan-Meier analysis indicated that breast cancer patients with high KIF26B expression had a shorter survival than those with low KIF26B expression. In addition, multivariate analysis indicated that KIF26B is an independent prognostic for outcome in breast cancer (HR, 2.356; 95%CI, 1.268-4.378; P = 0.007). Collectively, our study demonstrated that KIF26B was overexpression in breast cancer and could be served as a potential prognostic marker.
authors.affiliation: Department of General Surgery, Taihe Hospital, Hubei, Shiyan, People's Republic of China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Wang
authors.forename: Zong-Bin
authors.initials: ZB
authors.lastname: Zhao
authors.forename: Geng
authors.initials: G
authors.lastname: Wang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hui
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Wang
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Pan
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D006801:Humans; D053208:Kaplan-Meier Estimate; D016547:Kinesins / Q000235:genetics*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; C583839:KIF26B protein, human; D016547:Kinesins