title: A weight loss diet intervention has a similar beneficial effect on both metabolically abnormal obese and metabolically healthy but obese premenopausal women.
abstract: OBJECTIVE
  We studied the effect of a 12-week energy-restricted diet intervention on cardiometabolic risk in two groups of nonmorbid obese premenopausal Caucasian women, i.e. a metabolically abnormal obese (MAO) and a metabolically healthy but obese (MHO) group.
  
  
  METHODS
  The participants were 53 MAO and 25 MHO women (age range 19-49 years; body mass index inclusion criterion: 30-39.9). We assessed changes in body weight and composition, blood lipids, insulin resistance, hepatic enzymes, inflammatory markers and adipocytokines.
  
  
  RESULTS
  Overall, many of the study outcomes improved with the intervention in both MAO and MHO participants, but there was no difference in the magnitude of change between the groups. Body weight, waist circumference and total fat mass decreased significantly in response to the intervention in both MAO and MHO women (all p < 0.001). Fasting insulin, insulin resistance (homeostasis model assessment), hepatic enzymes (alanine aminotransferase and γ-glutamyltransferase), fatty liver index and leptin levels also decreased in both groups after the intervention (all p < 0.001), whereas total cholesterol, triglycerides and C-reactive protein decreased significantly only in MAO women (all p < 0.001).
  
  
  CONCLUSIONS
  These findings reinforce the idea that MHO women would also benefit from a lifestyle weight reduction intervention.
authors.affiliation: Department of Physical Education, School of Sport Sciences, University of Granada, Granada, Spain.
authors.forename: Jonatan R
authors.initials: JR
authors.lastname: Ruiz
authors.forename: Francisco B
authors.initials: FB
authors.lastname: Ortega
authors.forename: Idoia
authors.initials: I
authors.lastname: Labayen
mesh_terms: D050154:Adiposity; D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology / Q000517:prevention & control; D015228:Hypertriglyceridemia / Q000209:etiology / Q000517:prevention & control; D007333:Insulin Resistance; D008019:Life Style; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications / Q000178:diet therapy* / Q000503:physiopathology; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000178:diet therapy*; D017697:Premenopause; D012307:Risk Factors; D055105:Waist Circumference; D015431:Weight Loss; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein