title: Inflammatory cellular phenotypes and molecular mechanisms of glucocorticoid resistance in patients with bronchial asthma.
abstract: Asthma shows heterogeneity in the cellular sources of inflammation and response to therapy. Although glucocorticoids (GC) are very effective for the treatment of most patients with asthma, an important subgroup of patients fails to show clinical improvement. GC resistance (GC-R) could result from either inherited or acquired variation in GC sensitivity. Diverse cells, such as T helper (Th)1 cells, Th2 cells, and Th17 cells, and innate immunity associated pathways are involved in GC-R asthma. The GC receptor (GR) plays a central role in GC sensitivity. Recent molecular biological studies have revealed the involvement of protein kinase signaling to GR, GR phosphorylation, interactions of GR with excessive activation of transcription factors, and impaired histone deacetylase (HDAC). Long-acting β₂-adrenoceptor agonists (LABAs) may improve the clinical efficacy of GCs by enhancing GR function. Inhibitors of kinase pathways, such as p38 mitogen-activated protein kinase (MAPK) inhibitors and phosphoinositide-3-kinase (PI3K)δ inhibitors, are candidates for new therapeutic agents for GC-R asthma.
authors.affiliation: Department of Internal Medicine, Akishima Hospital, 1260 Nakagami-cho, Akishima-shi, Tokyo 196- 0022, Japan. y-matsumura@aki-hp.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Matsumura
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists / Q000494:pharmacology; D001249:Asthma / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology*; D004351:Drug Resistance / Q000502:physiology*; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use*; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D010641:Phenotype; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D012307:Risk Factors; D015398:Signal Transduction; D022021:Tacrolimus Binding Proteins; D014157:Transcription Factors / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism; D000099159:Tacrolimus Binding Protein 5
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D005938:Glucocorticoids; D006655:Histone Deacetylases; D019869:Phosphatidylinositol 3-Kinases; D011965:Receptors, Glucocorticoid; D022021:Tacrolimus Binding Proteins; D014157:Transcription Factors; D048051:p38 Mitogen-Activated Protein Kinases; D000099159:Tacrolimus Binding Protein 5; C561807:GLCCI1 protein, human