title: HLA typing in Brazilian boys with aromatic antiepileptic drug-induced DRESS.
abstract: METHODS
  We report two cases of drug rash with eosinophilia and systemic symptoms (DRESS) associated with the use of carbamazepine and phenytoin in Brazilian boys tested for human leukocyte antigen (HLA) class I and II alleles. The clinical manifestations were similar: a maculopapular eruption progressing to exfoliative erythroderma, fever, and lymphadenopathy. Leukocytosis, atypical lymphocytes, and liver injury were also observed. Assessment of causality using the Naranjo algorithm established a "probable" relationship (score 6) in both cases. Case 1 patient presented the following results of HLA typing: HLA-A*02,29 B*44,50 C*06,16 DRB1*01,07 DQA1*01,02. Case 2 patient presented the following results of HLA typing: HLAA*23,24 B*39,53 C*04,07 DRB1*04,08 DQA1*03,05 DQB1*03,03.
  
  
  CONCLUSIONS
  Neither of the cases reported here presented HLA typing similar to that strongly associated with the occurrence of DRESS in Asian or European patients.
authors.affiliation: Department of Pharmacology and Therapeutics, State University of Maringa, Avenue Colombo 5790, Maringá, PR 87020-290, Brazil.
authors.forename: Walderez Penteado
authors.initials: WP
authors.lastname: Gaeti
authors.forename: Paulo Roque
authors.initials: PR
authors.lastname: Obreli-Neto
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Moliterno
authors.forename: Gina Bressan
authors.initials: GB
authors.lastname: Schiavon
authors.forename: Roberto Kenji Nakamura
authors.initials: RK
authors.lastname: Cuman
mesh_terms: D000483:Alleles; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001938:Brazil; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology; D004802:Eosinophilia / Q000139:chemically induced / Q000276:immunology; D004827:Epilepsy / Q000188:drug therapy; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D002220:Carbamazepine; D010672:Phenytoin