title: LABAs in asthmatic children: highlights and new inside.
abstract: International asthma guidelines recommend increasing the dose of ICS or adding leukotriene modifiers or the use of long-acting inhaled beta2-agonists (LABAs) in combination with inhaled corticosteroids (ICS) when uncontrolled asthma occurs in adult and children in treatment with low-dose inhaled corticosteroids. However, in children, the effects of this last treatment option are unclear because there are few studies on the efficacy and safety of these drugs in pediatric age. Furthermore, salmeterol is licensed for use in children over 4 years and formoterol in children of more than 6 years. Finally, recent data provides evidence that repeated bronchoconstriction induces epithelial cell stress that may lead to remodeling and these findings may have potential implications for asthma management, particularly for LABAs treatment in the future.
authors.affiliation: Department of Pediatrics, Second University of Naples, Naples, Italy. michele.miraglia@unina2.it
authors.forename: M
authors.initials: M
authors.lastname: Miraglia del Giudice
authors.forename: M G
authors.initials: MG
authors.lastname: Matera
authors.forename: C
authors.initials: C
authors.lastname: Capristo
authors.forename: M
authors.initials: M
authors.lastname: Conte
authors.forename: F
authors.initials: F
authors.lastname: Santaniello
authors.forename: I
authors.initials: I
authors.lastname: Chinellato
authors.forename: S
authors.initials: S
authors.lastname: Leonardi
authors.forename: M C
authors.initials: MC
authors.lastname: Miraglia del Giudice
authors.forename: L
authors.initials: L
authors.lastname: Perrone
mesh_terms: D000280:Administration, Inhalation; D058666:Adrenergic beta-2 Receptor Agonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000367:Age Factors; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D017410:Practice Guidelines as Topic
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D018927:Anti-Asthmatic Agents; D003692:Delayed-Action Preparations; D005938:Glucocorticoids
keywords: Asthma; Children; LABAs