title: Human toll-like receptor 1 T1805G polymorphism and susceptibility to pulmonary tuberculosis in northern Spain.
abstract: Toll-like receptors (TLRs) are key sensors of mycobacterial infections and play a crucial role in the initiation and coordination of the antimycobacterial innate immune response. T1805G, a functional TLR1 single nucleotide polymorphism (SNP), has been associated with susceptibility to pulmonary tuberculosis (PTB), but contradictory results among different populations have been reported. Our objective was to study this SNP in a genetically homogeneous population to evaluate its role in conferring susceptibility or resistance to PTB. In our population, the 1805G allele and the GG genotype (OR 2.04, 95%CI 1.26-3.31) influence susceptibility to PTB, in contrast with data observed in other populations.
authors.affiliation: Immunology Service, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain. jgocejo@humv.es
authors.forename: J G
authors.initials: JG
authors.lastname: Ocejo-Vinyals
authors.forename: E
authors.initials: E
authors.lastname: Puente de Mateo
authors.forename: F
authors.initials: F
authors.lastname: Ausín
authors.forename: R
authors.initials: R
authors.lastname: Agüero
authors.forename: J L
authors.initials: JL
authors.lastname: Arroyo
authors.forename: M
authors.initials: M
authors.lastname: Gutiérrez-Cuadra
authors.forename: M C
authors.initials: MC
authors.lastname: Fariñas
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D010641:Phenotype; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013030:Spain; D051194:Toll-Like Receptor 1 / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000276:immunology / Q000382:microbiology
chemical_list: D051194:Toll-Like Receptor 1