title: Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation.
abstract: A disulfide bond is incorporated in the scaffold of thiosemicarbazone iron chelators as a reduction/activation switch. Following reduction, thiol-containing ligands stabilize iron ions in their trivalent oxidation state. The antiproliferative activity of the new chelating systems is assessed in human cancer cell lines and in normal tissue.
authors.affiliation: University of Arizona, Department of Chemistry and Biochemistry, 1306 E. University Blvd., Tucson, AZ 85721-0041, USA.
authors.forename: Tsuhen M
authors.initials: TM
authors.lastname: Chang
authors.forename: Elisa
authors.initials: E
authors.lastname: Tomat