title: High-dose daptomycin monotherapy cures Staphylococcus epidermidis 'endotipsitis' after failure of conventional therapy.
abstract: A 67-year-old gentleman developed persistent Staphylococcus epidermidis bacteraemia following transjugular intrahepatic portal shunting. 'Endotipsitis' was diagnosed. Conventional therapy with a vancomycin infusion, amikacin and rifampicin failed after 17 days. He was cured with a 6-week course of high-dose (8 mg/kg) daptomycin monotherapy.
authors.affiliation: Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust, Oxford, UK. jcolston@doctors.org.uk
authors.forename: Julia Marie
authors.initials: JM
authors.lastname: Colston
authors.forename: Matthew
authors.initials: M
authors.lastname: Scarborough
authors.forename: Jane
authors.initials: J
authors.lastname: Collier
authors.forename: Ian C J W
authors.initials: IC
authors.lastname: Bowler
mesh_terms: D000368:Aged; D000583:Amikacin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D057785:Catheters / Q000382:microbiology; D017576:Daptomycin / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008297:Male; D012293:Rifampin / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013212:Staphylococcus epidermidis; D017211:Treatment Failure; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D000583:Amikacin; D017576:Daptomycin; D012293:Rifampin