title: Case report: oseltamivir-induced resistant pandemic influenza A (H1N1) virus infection in a patient with AIDS and Pneumocystis jirovecii pneumonia.
abstract: Pneumocystis jirovecii pneumonia is the main cause of severe respiratory failure in patients with advanced HIV disease who do not receive P. jirovecii prophylaxis. Other aetiological agents may contribute to the respiratory failure in these patients, which is highlighted by the case described below: A patient with advanced HIV disease was treated for a dual-infection with pandemic influenza A (H1N1) and P. jirovecii. Initially, his condition improved, but deteriorated after the emergence of oseltamivir-resistant influenza virus. This is the first documented case of emergence of drug-resistant influenza virus in a patient infected with HIV with a pandemic influenza A (H1N1) and P. jirovecii double infection.
authors.affiliation: Department of Virology, Erasmus MC, Rotterdam, The Netherlands. j.vankampen@erasmusmc.nl
authors.forename: Jeroen J A
authors.initials: JJ
authors.lastname: van Kampen
authors.forename: Astrid J
authors.initials: AJ
authors.lastname: Bielefeld-Buss
authors.forename: Alewijn
authors.initials: A
authors.lastname: Ott
authors.forename: Jolanda
authors.initials: J
authors.lastname: Maaskant
authors.forename: Harald J
authors.initials: HJ
authors.lastname: Faber
authors.forename: Johan G
authors.initials: JG
authors.lastname: Lutisan
authors.forename: Charles A B
authors.initials: CA
authors.lastname: Boucher
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D060085:Coinfection; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D008297:Male; D053139:Oseltamivir / Q000627:therapeutic use*; D045363:Pneumocystis carinii; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy* / Q000821:virology
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir