title: Stochastic multi-scale prediction on the apparent elastic moduli of trabecular bone considering uncertainties of biological apatite (BAp) crystallite orientation and image-based modelling.
abstract: An assessment of the mechanical properties of trabecular bone is important in determining the fracture risk of human bones. Many uncertainty factors contribute to the dispersion of the estimated mechanical properties of trabecular bone. This study was undertaken in order to propose a computational scheme that will be able to predict the effective apparent elastic moduli of trabecular bone considering the uncertainties that are primarily caused by image-based modelling and trabecular stiffness orientation. The effect of image-based modelling which focused on the connectivity was also investigated. A stochastic multi-scale method using a first-order perturbation-based and asymptotic homogenisation theory was applied to formulate the stochastically apparent elastic properties of trabecular bone. The effective apparent elastic modulus was predicted with the introduction of a coefficient factor to represent the variation of bone characteristics due to inter-individual differences. The mean value of the predicted effective apparent Young's modulus in principal axis was found at approximately 460 MPa for respective 15.24% of bone volume fraction, and this is in good agreement with other experimental results. The proposed method may provide a reference for the reliable evaluation of the prediction of the apparent elastic properties of trabecular bone.
authors.affiliation: a Graduate School of Science and Technology, Keio University , 3-14-1 Hiyoshi, Yokohama 223-8522 , Japan.
authors.forename: Khairul Salleh
authors.initials: KS
authors.lastname: Basaruddin
authors.forename: Naoki
authors.initials: N
authors.lastname: Takano
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Nakano
mesh_terms: D001031:Apatites / Q000494:pharmacology*; D001842:Bone and Bones / Q000502:physiology*; D003460:Crystallization; D055119:Elastic Modulus; D006801:Humans; D021621:Imaging, Three-Dimensional; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000502:physiology; D008954:Models, Biological; D011336:Probability; D013269:Stochastic Processes; D035501:Uncertainty
chemical_list: D001031:Apatites
keywords: apparent elastic moduli; image-based modelling; stochastic multi-scale analysis; trabecular bone; uncertainties