title: Side effects of TNF-α blockers in patients with psoriatic arthritis: evidences from literature studies.
abstract: Psoriatic arthritis is an inflammatory rheumatic disorder, which occurs in patients with skin and/or nail psoriasis. In psoriatic arthritis, the importance of biologic mediators modulating inflammatory reaction, such as tumor necrosis factor, and the knowledge on their role in the pathogenesis of psoriatic arthritis influence the therapeutic choices. In the last years, the introduction of biologic drugs has greatly changed the treatment of psoriasis and psoriatic arthritis. In fact, tumor necrosis factor-α blockers demonstrated an effective action in the treatment of both skin and joint manifestations of psoriatic arthritis, but they have some adverse effects. The aim of this review is to revisit the literature data on adverse effects of tumor necrosis factor-α blockers in patients with psoriatic arthritis.
authors.affiliation: Rheumatology Research Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy. rosario.peluso2@unina.it
authors.forename: Rosario
authors.initials: R
authors.lastname: Peluso
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cafaro
authors.forename: Alessandro
authors.initials: A
authors.lastname: Di Minno
authors.forename: Salvatore
authors.initials: S
authors.lastname: Iervolino
authors.forename: Pasquale
authors.initials: P
authors.lastname: Ambrosino
authors.forename: Gelsy
authors.initials: G
authors.lastname: Lupoli
authors.forename: Matteo Nicola Dario
authors.initials: MN
authors.lastname: Di Minno
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015535:Arthritis, Psoriatic / Q000150:complications* / Q000188:drug therapy*; D001327:Autoimmune Diseases / Q000139:chemically induced; D001835:Body Weight / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000139:chemically induced; D009422:Nervous System Diseases / Q000139:chemically induced; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced; D012140:Respiratory Tract Diseases / Q000139:chemically induced; D012867:Skin / Q000187:drug effects; D012871:Skin Diseases / Q000150:complications / Q000628:therapy; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha