title: Synthesis of substituted estradiols by the selective aromatization of A-ring of steroidal 19-nor-Δ-4-3-ketones with phenylselenyl halides/hydrogen peroxide.
abstract: A range of 6-, 7-, and 11-substituted estradiols were synthesized by the selective aromatization of the A-ring of 19-nor steroids using phenylselenyl halides followed by oxidation with hydrogen peroxide. Established methods utilizing copper(II) halides failed or have given poor yields with these substrates.
authors.affiliation: Evestra Inc., San Antonio, TX, USA. bsanthamma@evestra.com
authors.forename: Bindu
authors.initials: B
authors.lastname: Santhamma
authors.forename: Klaus
authors.initials: K
authors.lastname: Nickisch
mesh_terms: D004958:Estradiol / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D007659:Ketones; D004958:Estradiol; D006861:Hydrogen Peroxide