title: Fluorinated tropanes.
abstract: The development of tropane-derivatives as cocaine-addiction therapeutics identified numerous compounds with affinities for the dopamine, serotonin, and norepinephrine transporters. Many of these compounds were then adapted for use as imaging radiotracers. Incorporation of fluorine into the molecule often improved the physiochemical properties of the compound and also provided a position for radiolabeling with fluorine-18. This review provides an overview of the efforts devoted to developing fluorine-18 radiolabeled tropanes for imaging use with positron emission tomography.
authors.affiliation: Center for Systems Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA. jstehou@emory.edu
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Stehouwer
mesh_terms: D000818:Animals; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D054879:Halogenation; D006801:Humans; D015394:Molecular Structure; D014326:Tropanes / Q000737:chemistry*
chemical_list: D005462:Fluorine Radioisotopes; D014326:Tropanes