title: [Limbic encephalitis: a new paraneoplastic auto-immune manifestation associated with metastatic melanoma?].
abstract: BACKGROUND
  Several studies indicate an association between immune-related manifestations and prolonged survival in metastatic melanoma. Limbic encephalitis driven by immune-mediated disorders may also be observed during the course of certain cancers.
  
  
  METHODS
  In November 2009, a 60-year-old woman followed up for metastatic melanoma since July 2005 developed rapidly progressive cognitive disorder. Clinical, biological, MRI and electroencephalogram abnormalities resulted in diagnosis of probably paraneoplastic limbic encephalitis in a context of immune-related manifestations although chemotoxicity could not be ruled out. Auto-immunity with hypothyroidism and thrombocytopenia were seen concomitantly.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first reported case of probably paraneoplastic limbic encephalitis associated with melanoma, a new example of an immune-related condition associated with prolonged survival in metastatic melanoma.
authors.affiliation: Service de dermatologie, hôpital Claude-Huriez, rue Michel-Polonovski, 59037 Lille cedex, France. coralie.becquart@univ-lille2.fr
authors.forename: C
authors.initials: C
authors.lastname: Becquart
authors.forename: G
authors.initials: G
authors.lastname: Ryckewaert
authors.forename: E
authors.initials: E
authors.lastname: Desmedt
authors.forename: L
authors.initials: L
authors.lastname: Defebvre
authors.forename: E
authors.initials: E
authors.lastname: Le Rhun
authors.forename: L
authors.initials: L
authors.lastname: Mortier
mesh_terms: D003072:Cognition Disorders / Q000209:etiology; D005260:Female; D006801:Humans; D020363:Limbic Encephalitis / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology*