title: Effect of photodynamic therapy on the skin using the ultrashort laser ablation.
abstract: Photodynamic Therapy (PDT) with 5-aminolevulinic acid (ALA) is known to be limited for applications in tumours of large volume mainly due to the limited penetration of topical photosensitization. The results show that micro-holes created using a femtosecond laser before PDT significantly increased the depth of PDT effect in the healthy tissue. The combination of ultrashort laser ablation technique with PDT showed an important scientific breakthrough related to transportation and delivery of drugs into the deeper regions of the tissue.
authors.affiliation: Physics Institute of Sao Carlos IFSC, University of Sao Paulo, Biophotonics Laboratory, Sao Carlos-SP, Brazil. gunicolodelli@hotmail.com.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Nicolodelli
authors.forename: Dora Patricia Ramírez
authors.initials: DP
authors.lastname: Angarita
authors.forename: Natalia Mayumi
authors.initials: NM
authors.lastname: Inada
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Tirapelli
authors.forename: Vanderlei Salvador
authors.initials: VS
authors.lastname: Bagnato
mesh_terms: D000622:Aminolevulinic Acid / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D016503:Drug Delivery Systems; D053685:Laser Therapy; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid
keywords: Photodynamic Therapy; Skin; aminolevulinic acid; ultrashort laser ablation