title: Wnt10b promotes differentiation of mouse hair follicle melanocytes.
abstract: Previous research has revealed that Wnt10b activates canonical Wnt signaling, which is integral to melanocyte differentiation in hair follicles (HFs). However, the function of Wnt10b in HF melanocytes remains poorly understood. We determined using Dct-LacZ transgenic mice that Wnt10b is mainly expressed near and within melanocytes of the hair bulbs during the anagen stage of the hair cycle. We also found that Wnt10b promotes an increase in melanocyte maturation and pigmentation in the hair bulbs of the mouse HF. To further explore the potential functions of Wnt10b in mouse HF melanocytes, we infected iMC23 cells with Ad-Wnt10b to overexpress Wnt10b. We demonstrated that Wnt10b promotes the differentiation of melanocytes by activating canonical Wnt signaling in melanocytes.
authors.affiliation: Bioengineering College, Chongqing University, Chongqing 400044, PR China.
authors.forename: Jixing
authors.initials: J
authors.lastname: Ye
authors.forename: Tian
authors.initials: T
authors.lastname: Yang
authors.forename: Haiying
authors.initials: H
authors.lastname: Guo
authors.forename: Yinhong
authors.initials: Y
authors.lastname: Tang
authors.forename: Fang
authors.initials: F
authors.lastname: Deng
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Li
authors.forename: Yizhan
authors.initials: Y
authors.lastname: Xing
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D018507:Gene Expression Regulation, Developmental; D018859:Hair Follicle / Q000254:growth & development* / Q000378:metabolism; D008544:Melanocytes / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D051153:Wnt Proteins / Q000235:genetics*; D060449:Wnt Signaling Pathway / Q000235:genetics
chemical_list: D051153:Wnt Proteins; C102068:Wnt10b protein, mouse
keywords: Differentiation.; Hair follicle; Melanocyte; Wnt/β-catenin signaling; Wnt10b