title: Acute effects of three club drugs on the striatum of rats: evaluation by quantitative autoradiography with [18F]FDOPA.
abstract: In this work, we used quantitative autoradiography to study the acute effect of cocaine, methamphetamine, and ketamine on the uptake of [(18)F]FDOPA in the striatum of rats. Drugs were treated 0.5 h before (pre-treated), and 1.5 h after (post-treated) [(18)F]FDOPA injections, rats were then sacrificed at 2 h post [(18)F]FDOPA injections to determine the striatum/frontal cortex binding ratios in the striatum. The ratios were lower in the post-treated groups than those of the pre-treated groups, suggesting a net effect of inhibition of trapping of the tracer. The order of uptake inhibition is: ketamine>methamphetamine>cocaine.
authors.affiliation: Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan.
authors.forename: Chun-Kai
authors.initials: CK
authors.lastname: Fang
authors.forename: Hong-Wen
authors.initials: HW
authors.lastname: Chen
authors.forename: Wei-Hsun
authors.initials: WH
authors.lastname: Wang
authors.forename: Ren-Shen
authors.initials: RS
authors.lastname: Liu
authors.forename: Jeng-Jong
authors.initials: JJ
authors.lastname: Hwang
mesh_terms: D000818:Animals; D001345:Autoradiography / Q000379:methods*; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D013287:Illicit Drugs / Q000633:toxicity*; D008297:Male; D008657:Metabolic Clearance Rate; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D051381:Rats; D014018:Tissue Distribution
chemical_list: D013287:Illicit Drugs; D019275:Radiopharmaceuticals; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine