title: Multivalent presentation of a hydrolytically stable GM(3) lactone mimetic as modulator of melanoma cells motility and adhesion.
abstract: A hydrolytically stable mimetic of the tumour antigen GM(3) lactone is used to decorate multivalent scaffolds. Two of them positively interfere on melanoma cell adhesion, migration and resistance to apoptosis (anoikis). Notably, their ability to hamper melanoma-cells adhesion and reduce the metastatic potential is enhanced when the two scaffolds, presenting a different shape, are used in combination.
authors.affiliation: Department of Chemistry, University of Florence, via della Lastruccia 3, 13 50019 Sesto F. no, FI, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Richichi
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Comito
authors.forename: Linda
authors.initials: L
authors.lastname: Cerofolini
authors.forename: Gabriele
authors.initials: G
authors.lastname: Gabrielli
authors.forename: Alberto
authors.initials: A
authors.lastname: Marra
authors.forename: Lisa
authors.initials: L
authors.lastname: Moni
authors.forename: Alice
authors.initials: A
authors.lastname: Pace
authors.forename: Lucia
authors.initials: L
authors.lastname: Pasquato
authors.forename: Paola
authors.initials: P
authors.lastname: Chiarugi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Dondoni
authors.forename: Lucio
authors.initials: L
authors.lastname: Toma
authors.forename: Cristina
authors.initials: C
authors.lastname: Nativi
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects*; D005679:G(M3) Ganglioside / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D008545:Melanoma / Q000378:metabolism / Q000473:pathology*
chemical_list: D005679:G(M3) Ganglioside; C047143:ganglioside GM3 lactone