title: [Complement system regulation and C3 glomerulopathy].
abstract: Complement system is a key system for immune surveillance and homeostasis. Excessive activation of complement system,especially the activation of alternative pathway may play a very important role in the pathogenesis of primary and secondary glomerulonephritis. C3 glomerulopathy is a newly named disease characterized by evident C3 deposition in the glomeruli with little or no immunoglobulin under immunofluorescence (IF). Its clinical and pathological manifestations vary a lot. The decreased plasma C3 and Factor H(FH)suggest that abnormal regulation of complement system plays an importment role in its pathogenesis. C3 glomerulopathy varies a lot as to its clinical manifestation, treatment and prognosis. The inhibition of excessive complement activation might be the key to treating C3 glomerulopathy.
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. huijiexiao2@hotmail.com
authors.forename: Hui-jie
authors.initials: HJ
authors.lastname: Xiao
authors.forename: Rui-juan
authors.initials: RJ
authors.lastname: He
mesh_terms: D003167:Complement Activation / Q000502:physiology*; D003176:Complement C3 / Q000378:metabolism*; D003170:Complement Pathway, Alternative / Q000276:immunology / Q000502:physiology*; D003165:Complement System Proteins / Q000276:immunology; D005921:Glomerulonephritis / Q000145:classification / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism / Q000473:pathology
chemical_list: D003176:Complement C3; D003165:Complement System Proteins