title: Serum paraoxonase activity and oxidative status in subjects with alopecia areata.
abstract: BACKGROUND
  Previous studies have suggested that oxidative stress may play an important role in the pathogenesis of alopecia areata (AA) but these reports are limited and conflicting.
  
  
  OBJECTIVE
  The aim of this study was to investigate serum paraoxonase-1 (PON1) activity and oxidative status in subjects with AA.
  
  
  METHODS
  Thirty-nine subjects with AA and 39 healthy controls were enrolled. Serum PON1 activity, total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) were determined.
  
  
  RESULTS
  Serum TAC levels and PON1 activity were significantly lower in the subjects with AA than controls (p = 0.038, p = 0.001, respectively), whereas TOS levels and OSI were significantly higher (both, p = 0.001) in the subjects with AA.
  
  
  CONCLUSIONS
  Our results suggest that reduced PON1 activity may be related to increased oxidant and decreased antioxidant levels. These data indicated that oxidant/antioxidant imbalance may play a role in the etiopathogenesis of AA.
authors.affiliation: Department of Dermatology, Yuzuncu Yil University, Van 65100, Turkey. drserapgunes@yahoo.com
authors.forename: Serap Gunes
authors.initials: SG
authors.lastname: Bilgili
authors.forename: Halil
authors.initials: H
authors.lastname: Ozkol
authors.forename: Ayse Serap
authors.initials: AS
authors.lastname: Karadag
authors.forename: Hatice Uce
authors.initials: HU
authors.lastname: Ozkol
authors.forename: Ayse
authors.initials: A
authors.lastname: Seker
authors.forename: Omer
authors.initials: O
authors.lastname: Calka
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
mesh_terms: D000293:Adolescent; D000328:Adult; D000506:Alopecia Areata / Q000097:blood*; D043303:Aryldialkylphosphatase / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human