title: The relationship between thrombin and platelets: linking vessel injury to thrombosis and inflammation.
abstract: Unfractionated heparin (UFH) does not effectively inhibit clot-bound thrombin and increases platelet reactivity, expression of P-selectin and inflammatory responses. These negative effects of UFH cannot be entirely overcome by the addition of a glycoprotein antagonist and may help explain the REPLACE-2 results.
authors.affiliation: University of Vermont in Burlington, Vermont, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Schneider
mesh_terms: D000991:Antithrombins / Q000494:pharmacology; D001792:Blood Platelets / Q000502:physiology*; D002986:Clinical Trials as Topic; D006629:Hirudins / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D010446:Peptide Fragments / Q000494:pharmacology; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D011994:Recombinant Proteins / Q000494:pharmacology; D013917:Thrombin / Q000502:physiology*; D013927:Thrombosis / Q000503:physiopathology*
chemical_list: D000991:Antithrombins; D006629:Hirudins; D010446:Peptide Fragments; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D011994:Recombinant Proteins; D013917:Thrombin; C074619:bivalirudin