title: Recent changes in endometrial cancer trends among menopausal-age U.S. women.
abstract: BACKGROUND
  Changes in endometrial cancer incidence rates after the precipitous decline in menopausal hormone therapy (MHT) use in 2002 have not been evaluated.
  
  
  METHODS
  Using data from the Surveillance, Epidemiology, and End Results Program from 1992 to 2009 (SEER 13), we identified 63428 incident endometrial cancer cases among women ages 20-74. We compared annual percent change (APC) in endometrial cancer incidence rates from 1992 to 2002 to rates from 2003 to 2009.
  
  
  RESULTS
  In contrast to the constant endometrial cancer rate pattern observed from 1992 to 2002 (APC 0.0%), rates increased after 2002 in women 50-74 years old (2.5%; PAPC comparison<0.01). Endometrial cancer incidence increased over the entire time period among women ages 20-49 (1992-2002: 1.1%; 2003-2009: 2.1%; PAPC comparison=0.21). Post-2002 increases in incidence among women ages 50-74 were specific to Type I endometrial tumors (1992-2002: -0.6%; 2003-2009: 1.6%; PAPC comparison<0.01).
  
  
  CONCLUSIONS
  The increase in endometrial cancer incidence rates after 2002 may be related to the widespread decrease in estrogen plus progestin MHT use, which has been reported to lower endometrial cancer risk in overweight and obese women.
authors.affiliation: Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
authors.forename: Paige
authors.initials: P
authors.lastname: Wartko
authors.forename: Mark E
authors.initials: ME
authors.lastname: Sherman
authors.forename: Hannah P
authors.initials: HP
authors.lastname: Yang
authors.forename: Ashley S
authors.initials: AS
authors.lastname: Felix
authors.forename: Louise A
authors.initials: LA
authors.lastname: Brinton
authors.forename: Britton
authors.initials: B
authors.lastname: Trabert
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D015914:Estrogen Replacement Therapy / Q000639:trends*; D005260:Female; D006801:Humans; D015994:Incidence; D008593:Menopause; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D050177:Overweight / Q000150:complications / Q000453:epidemiology; D018426:SEER Program; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult