title: Impact of depressive symptoms on oxidative stress in patients with psoriasis.
abstract: BACKGROUND
  Depression and anxiety disorders often accompany psoriasis. Increased reactive oxygen radicals and impaired antioxidant systems are considered to play a role both in psoriasis and depression and anxiety disorders. Accordingly, in this study, we aimed to investigate the effects of depressive and anxiety symptoms on oxidative stress in patients with psoriasis.
  
  
  METHODS
  Hospital Anxiety and Depression Scale (HADS) forms were completed by 39 psoriasis patients and 25 volunteer controls. Serum total antioxidant capacity (TAC) and total oxidant capacity (TOC) parameters were analysed in serum samples, after which oxidative stress index (OSI) was calculated in whole study population. Laboratory data were analysed with a Kruskal-Wallis test to determine the severity of HADS and the presence of psoriasis among four groups.
  
  
  RESULTS
  The psoriasis patients had higher HADS scores, higher OSI and TOC levels, and lower TAC levels compared with the control group. Comparison among four groups with/without psoriasis and higher/lower HADS scores revealed statistically significant differences with regard to TAC (Kruskal-Wallis P = 0.0047) and TOC (Kruskal-Wallis P < 0.001) levels and OSI (Kruskal-Wallis P < 0.001); the difference was mainly based on the difference between cases with and without psoriasis and on HADS scores in control subjects (P < 0.05 for post hoc comparisons). TAC, TOC, and OSI levels did not differ significantly in psoriasis patients with regard to higher or lower HADS scores.
  
  
  CONCLUSIONS
  Based on the findings of this study, the presence of either psoriasis or higher HADS scores in the control subjects was associated with increased oxidative stress, whereas presence of higher HADS scores did not lead to further increase in oxidative stress in psoriatic patients.
authors.affiliation: Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Karababa
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yesilova
authors.forename: Enver
authors.initials: E
authors.lastname: Turan
authors.forename: Salih
authors.initials: S
authors.lastname: Selek
authors.forename: Hacer
authors.initials: H
authors.lastname: Altun
authors.forename: Sahabettin
authors.initials: S
authors.lastname: Selek
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D001008:Anxiety Disorders / Q000378:metabolism*; D016022:Case-Control Studies; D003863:Depression / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress; D011565:Psoriasis / Q000378:metabolism* / Q000523:psychology*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D016877:Oxidants