title: Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.
abstract: Shedding light on grey matter: Fluorescent trimethine cyanines were evaluated as imaging probes for neurofibrillary tangles in post-mortem brain sections of Alzheimer's disease patients. These probes bind to neurofibrillary tangles with high contrast and selectivity over amyloid β plaques.
authors.affiliation: Clemens Schöpf-Institute of Chemistry and Biochemistry, Technische Universität Darmstadt, Darmstadt, Germany.
authors.forename: Jiamin
authors.initials: J
authors.lastname: Gu
authors.forename: Upendra Rao
authors.initials: UR
authors.lastname: Anumala
authors.forename: Roland
authors.initials: R
authors.lastname: Heyny-von Haußen
authors.forename: Jana
authors.initials: J
authors.lastname: Hölzer
authors.forename: Valérie
authors.initials: V
authors.lastname: Goetschy-Meyer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Mall
authors.forename: Ingrid
authors.initials: I
authors.lastname: Hilger
authors.forename: Christian
authors.initials: C
authors.lastname: Czech
authors.forename: Boris
authors.initials: B
authors.lastname: Schmidt
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002232:Carbocyanines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D008297:Male; D015394:Molecular Structure; D009831:Olfactory Mucosa / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D013329:Structure-Activity Relationship; D015027:Zebrafish / Q000196:embryology; D016875:tau Proteins / Q000032:analysis*
chemical_list: D000970:Antineoplastic Agents; D002232:Carbocyanines; D005456:Fluorescent Dyes; D016875:tau Proteins