title: Rectal adenocarcinoma coexisting with gastro-intestinal stromal tumor: a case report and literature review.
abstract: The finding of a gastrointestinal stromal tumor along with other epithelial cancers has been previously reported. Most commonly occurring in the GI tract, a second malignancy has been reported in nearly 13-20% patients with GIST. An elderly woman with a moderately differentiated adenocarcinoma of the rectum underwent low anterior resection. Histology revealed a low-grade GIST along with adenocarcinoma of the rectum, with no lymph node involvement or metastatic disease. This seems to be the first case of a simultaneous occurrence of a GIST along with a rectal adenocarcinoma. The high incidence of a second malignancy in patients with GIST points toward an increased susceptibility to cancer. Is it necessary to treat such patients as generalized cancer syndromes with intensive surveillance and cancer screening?
authors.affiliation: Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Harshal
authors.initials: H
authors.lastname: Rajekar
authors.forename: Amol
authors.initials: A
authors.lastname: Bhoje
authors.forename: Kim
authors.initials: K
authors.lastname: Vaiphei
mesh_terms: D000199:Actins / Q000378:metabolism; D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis; D012809:Colon, Sigmoid / Q000473:pathology; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications* / Q000175:diagnosis; D046152:Gastrointestinal Stromal Tumors / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D009367:Neoplasm Staging; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D012004:Rectal Neoplasms / Q000150:complications* / Q000175:diagnosis; D012007:Rectum / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000199:Actins; D019009:Proto-Oncogene Proteins c-kit