title: The neuroprotective activities and antioxidant activities of the polysaccharides from Saccharina japonica.
abstract: The crude polysaccharide (W) was extracted by water from Saccharina japonica and five fractions were separated by anion-exchange chromatography. And their chemical constituents, neuroprotective activities and antioxidant activities were studied. It showed that W had the neuroprotective activity while its fractions did not. In addition, the fractions displayed higher activities on hydroxyl-radical scavenging effects and reducing power than these of W. Moreover, it was speculated that the neuroprotective activities of samples were related to the hydroxyl-radical scavenging effect and reducing power while did not relate to superoxide-radical scavenging effect. Finally, it was concluded that some fractions could be good candidate antioxidants in food chemistry owing to the high antioxidant activities and their non-toxic characteristics.
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Jin
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Quanbin
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002852:Chromatography, Ion Exchange; D004353:Drug Evaluation, Preclinical; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010084:Oxidation-Reduction; D016627:Oxidopamine / Q000494:pharmacology; D000459:Phaeophyceae / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D019163:Reducing Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D052616:Solid Phase Extraction
chemical_list: D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D011134:Polysaccharides; D019163:Reducing Agents; D016627:Oxidopamine