title: Application of 2-octyl-cyanoacrylate for corneal perforation and glaucoma filtering bleb leak.
abstract: BACKGROUND
  This paper reports on the efficacy of a tissue adhesive, 2-octyl-cyanoacrylate, in the treatment of corneal perforation and glaucoma filtering bleb leak.
  
  
  METHODS
  Two eyes from two patients with corneal perforation or laceration and two eyes from two patients with bleb leak were included. The patients underwent application of 2-octyl-cyanoacrylate onto the perforated or leaking site, and a hydrogel contact lens was applied as a bandage. We also evaluated the in vitro cell toxicity of 2-octyl-cyanoacrylate in HeLa cells.
  
  
  RESULTS
  The two cases of corneal perforation were repaired within 22 days with one application of the tissue adhesive. The two cases of bleb leak were repaired with 2-4 applications of the tissue adhesive over 134 (range 17-134) days). There were no recurrences or adverse effects during a mean follow-up period of 12.7 months. In vitro testing revealed that 2-octyl-cyanoacrylate was markedly toxic to HeLa cells.
  
  
  CONCLUSIONS
  Four patients with corneal perforation or bleb leak were successfully managed using 2-octyl-cyanoacrylate tissue adhesive. This simple and easy surgical technique may become an alternative therapeutic option for corneal perforation or bleb leak, although several applications of this tissue adhesive may be required. Although 2-octyl-cyanoacrylate was toxic to HeLa cells, no adverse clinical effects were noted using this adhesive.
authors.affiliation: Department of Regenerative Medicine, University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences, Toyama.
authors.forename: Motonori
authors.initials: M
authors.lastname: Okabe
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kitagawa
authors.forename: Toshiko
authors.initials: T
authors.lastname: Yoshida
authors.forename: Chika
authors.initials: C
authors.lastname: Koike
authors.forename: Takeshi
authors.initials: T
authors.lastname: Katsumoto
authors.forename: Etsuko
authors.initials: E
authors.lastname: Fujihara
authors.forename: Toshio
authors.initials: T
authors.lastname: Nikaido
keywords: 2-octyl-cyanoacrylate; bleb leak; corneal perforation; tissue adhesive