title: Live birth rates following in vitro fertilization in women with thyroid autoimmunity and/or subclinical hypothyroidism.
abstract: OBJECTIVE
  To investigate whether the live birth rate following in vitro fertilization (IVF) is affected by thyroid autoimmunity (TAI) and/or subclinical hypothyroidism in subfertile women.
  
  
  METHODS
  Retrospective study in a university infertility clinic.
  
  
  METHODS
  A total of 627 women without past or current history of thyroid disorder undergoing their first IVF cycle.
  
  
  METHODS
  Pre-IVF archived blood serum samples were tested for TAI and thyroid function tests.
  
  
  METHODS
  Live birth rate.
  
  
  RESULTS
  The clinical pregnancy rate, live birth rate and miscarriage rate were similar among women with or without TAI and/or subclinical hypothyroidism using a TSH threshold 4·5 mIU/l. Thyroid autoantibody level did not affect these IVF outcomes.
  
  
  CONCLUSIONS
  The live birth rate and miscarriage rate of women with TAI and/or subclinical hypothyroidism following IVF were not impaired.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administration Region, China.
authors.forename: Joyce
authors.initials: J
authors.lastname: Chai
authors.forename: Wing-Yee T
authors.initials: WY
authors.lastname: Yeung
authors.forename: Chi-Yan V
authors.initials: CY
authors.lastname: Lee
authors.forename: Hang-Wun R
authors.initials: HW
authors.lastname: Li
authors.forename: Pak-Chung
authors.initials: PC
authors.lastname: Ho
authors.forename: Hung-Yu E
authors.initials: HY
authors.lastname: Ng
mesh_terms: D000328:Adult; D015551:Autoimmunity / Q000276:immunology*; D001723:Birth Rate; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007037:Hypothyroidism / Q000276:immunology*; D011247:Pregnancy; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000276:immunology*