title: Evolution of high-level daptomycin resistance in Enterococcus faecium during daptomycin therapy is associated with limited mutations in the bacterial genome.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Kelesidis
authors.forename: Ryan
authors.initials: R
authors.lastname: Tewhey
authors.forename: Romney M
authors.initials: RM
authors.lastname: Humphries
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D017576:Daptomycin / Q000494:pharmacology / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D016984:Enterococcus faecium / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D016680:Genome, Bacterial; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D009154:Mutation; D017422:Sequence Analysis, DNA; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000382:microbiology; D013964:Thyroid Neoplasms / Q000150:complications
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D017576:Daptomycin
keywords: cardiolipin synthetase; hypercalcaemia; whole-genome sequencing