title: Prioritization of Disease Susceptibility Genes Using LSM/SVD.
abstract: Understanding the role of genetics in diseases is one of the most important tasks in the postgenome era. It is generally too expensive and time consuming to perform experimental validation for all candidate genes related to disease. Computational methods play important roles for prioritizing these candidates. Herein, we propose an approach to prioritize disease genes using latent semantic mapping based on singular value decomposition. Our hypothesis is that similar functional genes are likely to cause similar diseases. Measuring the functional similarity between known disease susceptibility genes and unknown genes is to predict new disease susceptibility genes. Taking autism as an instance, the analysis results of the top ten genes prioritized demonstrate they might be autism susceptibility genes, which also indicates our approach could discover new disease susceptibility genes. The novel approach of disease gene prioritization could discover new disease susceptibility genes, and latent disease-gene relations. The prioritized results could also support the interpretive diversity and experimental views as computational evidence for disease researchers.
authors.forename: Lejun
authors.initials: L
authors.lastname: Gong
authors.forename: Ronggen
authors.initials: R
authors.lastname: Yang
authors.forename: Qin
authors.initials: Q
authors.lastname: Yan
authors.forename: Xiao
authors.initials: X
authors.lastname: Sun
mesh_terms: D000465:Algorithms; D001321:Autistic Disorder / Q000235:genetics; D035843:Biomedical Research; D019295:Computational Biology / Q000379:methods*; D005796:Genes / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000145:classification*; D006801:Humans; D008957:Models, Genetic