title: Radiolabelled nanohydroxyapatite with 99mTc: perspectives to nanoradiopharmaceuticals construction.
abstract: The use of nanoparticles is under intense investigation. The possible advantages proposed by these systems are very impressive and the results may be quite schemer. In this scenario, the association of nanoparticles with radioactive materials (radionuclide) may be the most important step since the discovery of radioactive for nuclear medicine and radiopharmacy, especially for cancer targeting and therapy. In this study, we developed radiolabelled nanoparticles of hydroxyapatite with technetium 99m for bone cancer imaging. The results demonstrated that it is possible to label nanoparticles of hydroxyapatite, and due to its physicochemical properties is possible to develop nano-radiopharmaceutical for bone imaging.
authors.affiliation: University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro , Rio de Janeiro , Brazil.
authors.forename: Marta de Souza
authors.initials: Mde S
authors.lastname: Albernaz
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Ospina
authors.forename: Alexandre Malta
authors.initials: AM
authors.lastname: Rossi
authors.forename: Ralph
authors.initials: R
authors.lastname: Santos-Oliveira
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001769:Blood / Q000378:metabolism*; D002626:Chemistry, Pharmaceutical / Q000639:trends; D055808:Drug Discovery; D017886:Durapatite / Q000737:chemistry; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D051379:Mice; D058990:Molecular Targeted Therapy; D053758:Nanoparticles / Q000737:chemistry; D013667:Technetium / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D001672:Biocompatible Materials; D013667:Technetium; D017886:Durapatite