title: Neuregulin-1 type I: a hidden power within Schwann cells for triggering peripheral nerve remyelination.
abstract: Physiological interactions and reciprocal signaling between axons and Schwann cells play critical roles in nerve development and survival. Axonally derived neuregulin-1 (NRG-1) type III is an essential modulator of Schwann cells during development, nerve repair, and remyelination. A recent report demonstrates an unexpected regulatory role for Schwann cell-derived NRG-1 type I in Schwann cell plasticity and remyelination after peripheral nerve injury. Specifically expressed in Schwann cells at critical time points after nerve injury, this isoform of NRG-1 emerges as a driving force for regeneration and remyelination programs.
authors.affiliation: Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada. akrishna@ucalgary.ca
authors.forename: Anand
authors.initials: A
authors.lastname: Krishnan
mesh_terms: D001369:Axons / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009186:Myelin Sheath / Q000378:metabolism*; D009416:Nerve Regeneration / Q000502:physiology*; D020890:Neuregulin-1 / Q000235:genetics / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D012583:Schwann Cells / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
chemical_list: C094131:NRG1 protein, human; D020890:Neuregulin-1; D020033:Protein Isoforms