title: Retrospective evaluation of antibody index of human parvovirus B19 as a prognostic factor in patients with dilated and ischemic cardiomyopathy.
abstract: Cardiotropic viral infections are important causative factors in dilated cardiomyopathy. This retrospective study examined the antibody index for human parvovirus B19 in patients suffering from dilated or ischemic cardiomyopathy as a prognostic factor for stable left ventricular function. Blood specimens from 43 patients with the diagnosis of dilated or ischemic cardiomyopathy were analyzed for human parvovirus B19 by polymerase chain reaction (PCR) and enzyme immunoassay kit for qualitative determination of IgG and IgM antibodies. To exclude patients with acute myocarditis, only patients with onset of symptoms more than 4 months previously were included. Patients with dilated cardiomyopathy and a high antibody index showed a significantly better clinical outcome when compared to patients with a low IgG antibody index (8.5 ± 2.4 vs. 3.1 ± 2.6; P = 0.006). There was no significant difference in left ventricular ejection fraction between patients with a high antibody index and patients with a lower antibody index (P = 0.59). The presence of human parvovirus B19 antibodies is associated with protective immunity. A high antibody index seems to be a good prognostic factor for the disease correlating to a relatively stable left ventricular ejection fraction.
authors.affiliation: Head Office of Vienna Hospital Association, Vienna, Austria.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Zedtwitz-Liebenstein
authors.forename: Oliver
authors.initials: O
authors.lastname: Robak
authors.forename: Heinz
authors.initials: H
authors.lastname: Burgmann
authors.forename: Michael
authors.initials: M
authors.lastname: Frass
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D010322:Parvoviridae Infections / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D016732:Parvovirus B19, Human / Q000276:immunology*; D011379:Prognosis; D012189:Retrospective Studies; D016277:Ventricular Function, Left
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M