title: Time-domain reflectance diffuse optical tomography with Mellin-Laplace transform for experimental detection and depth localization of a single absorbing inclusion.
abstract: We show how to apply the Mellin-Laplace transform to process time-resolved reflectance measurements for diffuse optical tomography. We illustrate this method on simulated signals incorporating the main sources of experimental noise and suggest how to fine-tune the method in order to detect the deepest absorbing inclusions and optimize their localization in depth, depending on the dynamic range of the measurement. To finish, we apply this method to measurements acquired with a setup including a femtosecond laser, photomultipliers and a time-correlated single photon counting board. Simulations and experiments are illustrated for a probe featuring the interfiber distance of 1.5 cm and show the potential of time-resolved techniques for imaging absorption contrast in depth with this geometry.
authors.affiliation: CEA-LETI, Minatec Campus, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
authors.forename: Agathe
authors.initials: A
authors.lastname: Puszka
authors.forename: Lionel
authors.initials: L
authors.lastname: Hervé
authors.forename: Anne
authors.initials: A
authors.lastname: Planat-Chrétien
authors.forename: Anne
authors.initials: A
authors.lastname: Koenig
authors.forename: Jacques
authors.initials: J
authors.lastname: Derouard
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Dinten
keywords: (170.3010) Image reconstruction techniques; (170.3880) Medical and biological imaging; (170.4580) Optical diagnostics for medicine; (170.6920) Time-resolved imaging; (170.6960) Tomography; (170.7050) Turbid media