title: Immune system, cell senescence, aging and longevity--inflamm-aging reappraised.
abstract: Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm-aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.
authors.affiliation: Department of Experimental Pathology, University of Bologna, via S. Giacomo 12, 40126 Bologna Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Salvioli
authors.forename: Daniela
authors.initials: D
authors.lastname: Monti
authors.forename: Catia
authors.initials: C
authors.lastname: Lanzarini
authors.forename: Maria
authors.initials: M
authors.lastname: Conte
authors.forename: Chiara
authors.initials: C
authors.lastname: Pirazzini
authors.forename: Maria Giulia
authors.initials: MG
authors.lastname: Bacalini
authors.forename: Paolo
authors.initials: P
authors.lastname: Garagnani
authors.forename: Cristina
authors.initials: C
authors.lastname: Giuliani
authors.forename: Elisa
authors.initials: E
authors.lastname: Fontanesi
authors.forename: Rita
authors.initials: R
authors.lastname: Ostan
authors.forename: Laura
authors.initials: L
authors.lastname: Bucci
authors.forename: Federica
authors.initials: F
authors.lastname: Sevini
authors.forename: Stella Lukas
authors.initials: SL
authors.lastname: Yani
authors.forename: Annalaura
authors.initials: A
authors.lastname: Barbieri
authors.forename: Laura
authors.initials: L
authors.lastname: Lomartire
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Borelli
authors.forename: Dario
authors.initials: D
authors.lastname: Vianello
authors.forename: Elena
authors.initials: E
authors.lastname: Bellavista
authors.forename: Morena
authors.initials: M
authors.lastname: Martucci
authors.forename: Elisa
authors.initials: E
authors.lastname: Cevenini
authors.forename: Elisa
authors.initials: E
authors.lastname: Pini
authors.forename: Maria
authors.initials: M
authors.lastname: Scurti
authors.forename: Fiammetta
authors.initials: F
authors.lastname: Biondi
authors.forename: Aurelia
authors.initials: A
authors.lastname: Santoro
authors.forename: Miriam
authors.initials: M
authors.lastname: Capri
authors.forename: Claudio
authors.initials: C
authors.lastname: Franceschi
mesh_terms: D000375:Aging; D017209:Apoptosis; D016922:Cellular Senescence; D004247:DNA / Q000097:blood; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007249:Inflammation / Q000503:physiopathology*; D008136:Longevity
chemical_list: D004247:DNA