title: [Fe]-hydrogenase and models that contain iron-acyl ligation.
abstract: [Fe]-hydrogenase is a newly characterized type of hydrogenase. This enzyme heterolytically splits hydrogen in the presence of a natural substrate. The active site of the enzyme contains a mono-iron complex with intriguing iron-acyl ligation. Several groups have recently developed iron-acyl complexes as synthetic models of [Fe]-hydrogenase. This Focus Review summarizes the studies of this enzyme and its model compounds, with an emphasis on our own research in this area.
authors.affiliation: Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), SB-ISIC-LSCI, BCH 3305, Lausanne, CH 1015, Switzerland.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Schultz
authors.forename: Dafa
authors.initials: D
authors.lastname: Chen
authors.forename: Xile
authors.initials: X
authors.lastname: Hu
mesh_terms: D000215:Acylation; D020134:Catalytic Domain; D006864:Hydrogenase / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D007506:Iron-Sulfur Proteins / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D056928:X-Ray Absorption Spectroscopy
chemical_list: D007506:Iron-Sulfur Proteins; D008024:Ligands; D007501:Iron; C118830:iron hydrogenase; D006864:Hydrogenase