title: The use of near-infrared and microwave resonance sensing to monitor a continuous roller compaction process.
abstract: Roller compaction is commonly used in the pharmaceutical and nutraceutical industries to increase and narrow the size distribution of a particulate material, making it easier to process. Both the moisture content of the material and the density of the roller compacted ribbon affect the uniformity and physical properties of the resultant granules. Without process analytical technologies, these parameters cannot be determined on-line or in real time. In this study, the more commonly used near-infrared (NIR) spectroscopy was compared and contrasted with microwave resonance for the determination of roller-compacted ribbons' envelope density and moisture content. Results indicate that microwave resonance can offer improved accuracy, robustness, and ease-of-use compared with NIR spectroscopy for these property measurements.
authors.affiliation: School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907-2100.
authors.forename: John
authors.initials: J
authors.lastname: Austin
authors.affiliation: School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907-2100.
authors.forename: Anshu
authors.initials: A
authors.lastname: Gupta
authors.affiliation: School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907-2100.
authors.forename: Ryan
authors.initials: R
authors.lastname: Mcdonnell
authors.affiliation: School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907-2100.
authors.forename: Gintaras V
authors.initials: GV
authors.lastname: Reklaitis
authors.affiliation: School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907-2100. Electronic address: mtharris@purdue.edu.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Harris
mesh_terms: D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D008872:Microwaves; D015999:Multivariate Analysis; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011208:Powders; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations; D011208:Powders; D014867:Water