title: Angiotensin-converting enzyme insertion/deletion polymorphism and risk of myocardial infarction in an updated meta-analysis based on 34993 participants.
abstract: The association between angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism and risk of myocardial infarction (MI) has been extensively studied. However, the results were in controversy. This study aimed to explore the association between ACE I/D polymorphism and risk of MI by using a meta-analysis. We retrieved the following databases to indentify eligible studies: Medline, Embase, ISI, VIP, CBM and Wan Fang database. The latest update was 10th May, 2012. Odds ratio and 95% confidence interval (95% CI) were used to present the strength of the association. A total of 40 case-control studies with 34993 participants were included. Overall, D allele of ACE I/D polymorphism was significantly associated with an increased risk of MI in genetic comparison models (OR (95% CI): 1.41 (1.22-1.64) for DD vs. II; 1.11 (1.01-1.21) for ID vs. II; 1.23 (1.10-1.37) for D carriers vs. II; 1.28 (1.15-1.43) for DD vs. I carriers and 1.06 (1.02-1.10) for D carriers vs. I carriers). Subgroup analyses, according to ethnicities and countries of participants also indicated that D allele was significantly associated with an increased risk of MI in Asians (especially for Chinese) and Caucasians (especially for English, French, Germans and Italians) (OR (95% CI) of DD vs. ID+II: 2.11 (1.65-2.70) for Asians and 1.15 (1.05-1.27) for Caucasians). In conclusion, this meta-analysis indicated that D allele of ACE I/D polymorphism was a possible risk factor for MI incidence for both Asians and Caucasians.
authors.affiliation: Department of Anesthesiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing City, Jiang Su Province 210029, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Shiyang
authors.initials: S
authors.lastname: Dong
authors.forename: Mingfeng
authors.initials: M
authors.lastname: He
authors.forename: Tao
authors.initials: T
authors.lastname: Qi
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000235:genetics*; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk; D012307:Risk Factors
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A