title: [Prognostic evaluations of recurrent gliomas and preliminary efficacies of combined modality therapy].
abstract: OBJECTIVE
  To evaluate the prognosis and efficacies of comprehensive treatment for recurrent gliomas.
  
  
  METHODS
  A total of 62 patients diagnosed as recurrent gliomas at our hospital between May 2007 and January 2012 were reviewed and analyzed. The investigators compared the prognosis of different grades of gliomas and evaluated the efficacies of combined modality therapy of surgery, radiotherapy, chemotherapy and immunotherapy.
  
  
  RESULTS
  Their median periods of time-to-progression (TTP) and overall survival (OS) were 6.0 and 13.0 months respectively. The median TTP of WHO grade II (n = 21), III (n = 13) and IV (n = 28) recurrent gliomas were 9.0, 9.0 and 5.0 months respectively. And the average OS of WHO grade II, III and IV recurrent gliomas were 26.6, 21.4 and 13.8 months respectively. The efficacious rate of chemotherapy was 26.7%.
  
  
  CONCLUSIONS
  Combined modality therapy based on chemotherapy may moderately improve the prognosis of recurrent gliomas. And the pathological grades of primary tumors are correlated with the prognosis of recurrent gliomas.
authors.affiliation: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Yao
authors.forename: Zhi-yong
authors.initials: ZY
authors.lastname: Qin
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Jin-song
authors.initials: JS
authors.lastname: Wu
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.forename: Liang-fu
authors.initials: LF
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005910:Glioma / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult