title: The role of Homer 1a in increasing locomotor activity and non-selective attention, and impairing learning and memory abilities.
abstract: The current study aimed to investigate the possible role of Homer 1a in the etiology and pathogenesis of attention deficit hyperactivity disorder (ADHD). We divided 32 rats into four groups. The rats in the RNAi-MPH group were given the lentiviral vector containing Homer 1a-specific miRNA (Homer 1a-RNAi-LV) by intracerebroventricular injection, and 7 days later they were given three daily doses of methylphenidate (MPH) by intragastric gavage. The RNAi-SAL group was given Homer 1a-RNAi-LV and saline later. The NC-MPH group was given the negative control lentiviral vector (NC-LV) and MPH later. The NC-SAL group was given NC-LV and saline later. Rats that were given Homer 1a RNAi exhibited increased locomotor activity and non-selective attention, and impaired learning and memory abilities, which is in line with the behavioral findings of animal models of ADHD. However, MPH ameliorated these abnormal behaviors. All findings indicated that Homer 1a may play an important role in the etiology and pathogenesis of ADHD.
authors.affiliation: Institute of Pediatrics of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Qin
authors.initials: Q
authors.lastname: Hong
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Pan
authors.forename: Mei
authors.initials: M
authors.lastname: Guo
authors.forename: Li
authors.initials: L
authors.lastname: Fei
authors.forename: Xi-Rong
authors.initials: XR
authors.lastname: Guo
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Tong
authors.forename: Xia
authors.initials: X
authors.lastname: Chi
mesh_terms: D000818:Animals; D001288:Attention / Q000502:physiology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000139:chemically induced; D002352:Carrier Proteins / Q000008:administration & dosage / Q000502:physiology*; D005822:Genetic Vectors / Q000008:administration & dosage; D000072233:Homer Scaffolding Proteins; D057967:Infusions, Intraventricular; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008568:Memory / Q000187:drug effects / Q000502:physiology; D008774:Methylphenidate / Q000008:administration & dosage; D035683:MicroRNAs / Q000008:administration & dosage; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins; D035683:MicroRNAs; D008774:Methylphenidate