title: IL-15 that a regulator of TNF-α in patients with diabetes mellitus type 2.
abstract: Diabetes mellitus type 2 (DM2), obesity, and the metabolic syndrome are considered that a low-grade chronic inflammatory condition. Although synthesis of different pro- and anti-inflammatory cytokines has been implicated in this process, this low-grade inflammatory condition is characterized especially by an increase in Tumor Necrosis Factor alpha (TNF-α), a cytokine that has been associated to the development of insulin resistance and muscle wasting in the diabetic patients. In consequence, mechanisms implicated in attenuating the deleterious effects of TNF-α are activated. One of these mechanisms may involve interleukin 15 (IL-15), which has proven effect on intermediate metabolisms, regulating blood glucose and lipid levels, and diminishing proteolysis in striated muscle. This suggests that the induction of endogenous IL-15 production by a simple event as physical activity may aid in decreasing or even inhibiting the negative effects of TNF-α in patient with DM2 or obesity, in which a low grade chronic inflammatory condition is present.
authors.affiliation: Higher School of Medicine of National Polytechnic Institute, Mexico.
authors.forename: Roberto
authors.initials: R
authors.lastname: Sánchez-Jiménez
authors.forename: Noé
authors.initials: N
authors.lastname: Alvarado-Vásquez
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000628:therapy; D005081:Exercise Therapy / Q000379:methods; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D019409:Interleukin-15 / Q000378:metabolism* / Q000494:pharmacology; D009043:Motor Activity / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000009:adverse effects / Q000378:metabolism*
chemical_list: D019409:Interleukin-15; D014409:Tumor Necrosis Factor-alpha; D005947:Glucose