title: Effects of meloxicam on milk production, behavior, and feed intake in dairy cows following assisted calving.
abstract: Parturition is a necessary event for production in dairy cattle, and assistance at calving is common. There is limited use of nonsteroidal antiinflammatory drugs for the alleviation of calving pain and a paucity of research on the effects of these drugs on postpartum health and performance. This randomized triple blind clinical trial involved Holstein cows (n=42) and heifers (n=61) that experienced an assisted parturition. These animals received either 1 injection of meloxicam (0.5mg/kg of body weight) or placebo subcutaneously 24h following calving. Outcome measures included dry matter intake (DMI) and milk production for the first 14d in milk, blood metabolites sampled over 12d, health events for the first 60d in milk, as well as lying and feeding behavior 24h following injection. Continuous data were analyzed using multivariable regression models. Binary outcomes were analyzed using a mixed logistic model with cow modeled using a random intercept. This study failed to show any significant effects of treatment on DMI, milk production, blood metabolites, or health events. A possible explanation for the lack of treatment differences could be that the meloxicam was administered too late after calving. Meloxicam increased feeding time as well as bunk visit frequency in the 24h following injection. Regardless of treatment, animals that had retained fetal membranes produced less milk and had higher serum haptoglobin concentrations. Future research is warranted to examine the effects of antiinflammatory drugs administered closer to the time of calving on health and production.
authors.affiliation: Department of Population Medicine, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
authors.forename: Nathalie C
authors.initials: NC
authors.lastname: Newby
authors.forename: David L
authors.initials: DL
authors.lastname: Pearl
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Leblanc
authors.forename: Ken E
authors.initials: KE
authors.lastname: Leslie
authors.forename: Marina A G
authors.initials: MA
authors.lastname: von Keyserlingk
authors.forename: Todd F
authors.initials: TF
authors.lastname: Duffield
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000097:blood; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004420:Dystocia / Q000188:drug therapy / Q000662:veterinary*; D004435:Eating / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D007774:Lactation / Q000187:drug effects*; D000077239:Meloxicam; D008892:Milk; D010146:Pain / Q000188:drug therapy / Q000662:veterinary; D036801:Parturition; D010919:Placebos; D011247:Pregnancy; D013843:Thiazines / Q000009:adverse effects* / Q000627:therapeutic use; D013844:Thiazoles / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005230:Fatty Acids, Nonesterified; D010919:Placebos; D013843:Thiazines; D013844:Thiazoles; D020155:3-Hydroxybutyric Acid; D000077239:Meloxicam