title: Impact of a home-based walking intervention on outcomes of sleep quality, emotional distress, and fatigue in patients undergoing treatment for solid tumors.
abstract: Exercise use among patients with cancer has been shown to have many benefits and few notable risks. The purpose of this study was to evaluate the impact of a home-based walking intervention during cancer treatment on sleep quality, emotional distress, and fatigue. Methods. A total of 138 patients with prostate (55.6%), breast (32.5%), and other solid tumors (11.9%) were randomized to a home-based walking intervention or usual care. Exercise dose was assessed using a five-item subscale of the Cooper Aerobics Center Longitudinal Study Physical Activity Questionnaire. Primary outcomes of sleep quality, distress, and fatigue were compared between the two study arms. Results. The exercise group (n = 68) reported more vigor (p = .03) than control group participants (n = 58). In dose response models, greater participation in aerobic exercise was associated with 11% less fatigue (p < .001), 7.5% more vigor (p = .001), and 3% less emotional distress (p = .03), after controlling for intervention group assignment, age, and baseline exercise and fatigue levels. Conclusion. Patients who exercised during cancer treatment experienced less emotional distress than those who were less active. Increasing exercise was also associated with less fatigue and more vigor. Home-based walking is a simple, sustainable strategy that may be helpful in improving a number of symptoms encountered by patients undergoing active treatment for cancer.
authors.affiliation: School of Nursing, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2110, USA. jwenzel@jhu.edu
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Wenzel
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Griffith
authors.forename: Jingjing
authors.initials: J
authors.lastname: Shang
authors.forename: Carol B
authors.initials: CB
authors.lastname: Thompson
authors.forename: Haley
authors.initials: H
authors.lastname: Hedlin
authors.forename: Kerry J
authors.initials: KJ
authors.lastname: Stewart
authors.forename: Theodore
authors.initials: T
authors.lastname: DeWeese
authors.forename: Victoria
authors.initials: V
authors.lastname: Mock
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy / Q000009:adverse effects; D005081:Exercise Therapy; D005221:Fatigue / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000628:therapy*; D012893:Sleep Wake Disorders / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D016138:Walking