title: p53 as a neoplastic biomarker in patients with erosive and plaque like forms of oral lichen planus.
abstract: OBJECTIVE
  Unstimulated whole salivary p53 was assessed in patients suffering from erosive and plaque-like form of oral lichen planus (OLP).
  
  
  METHODS
  Eighteen patients with erosive form, 17 patients suffering from plaque-like form and 38 noninvolvement subjects were enrolled. The unstimulated whole saliva p53 level was assayed by ELISA.
  
  
  RESULTS
  The mean concentration of salivary p53 was significantly higher in patients with plaque-like form compared to both patients with erosive form and the control group.
  
  
  CONCLUSIONS
  We conclude that plaque like form of OLP is important in view of the potential for malignancy and is not safety form.
  
  
  CONCLUSIONS
  It seems that all forms of OLP must be considered accurately, should be followed up with biannual examinations, and if possible, assessment of salivary p53 every year.
authors.affiliation: Department of Oral Medicine, Dental Research Center, Dentistry School, Tehran University of Medical Sciences, Tehran, Iran. aghahose@sina.tums.ac.ir
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Agha-Hosseini
authors.forename: Iraj
authors.initials: I
authors.lastname: Mirzaii-Dizgah
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000145:classification* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology; D012463:Saliva / Q000737:chemistry; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53