title: Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease.
abstract: BACKGROUND
  Recent genome-wide association studies (GWAS) have identified novel loci associated with sudden cardiac death (SCD). Despite this progress, identified DNA variants account for a relatively small portion of overall SCD risk, suggesting that additional loci contributing to SCD susceptibility await discovery. The objective of this study was to identify novel DNA variation associated with SCD in the context of coronary artery disease (CAD).
  
  
  RESULTS
  Using the MetaboChip custom array we conducted a case-control association analysis of 119,117 SNPs in 948 SCD cases (with underlying CAD) from the Oregon Sudden Unexpected Death Study (Oregon-SUDS) and 3,050 controls with CAD from the Wellcome Trust Case-Control Consortium (WTCCC). Two newly identified loci were significantly associated with increased risk of SCD after correction for multiple comparisons at: rs6730157 in the RAB3GAP1 gene on chromosome 2 (P = 4.93×10(-12), OR = 1.60) and rs2077316 in the ZNF365 gene on chromosome 10 (P = 3.64×10(-8), OR = 2.41).
  
  
  CONCLUSIONS
  Our findings suggest that RAB3GAP1 and ZNF365 are relevant candidate genes for SCD and will contribute to the mechanistic understanding of SCD susceptibility.
authors.affiliation: The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
authors.forename: Adriana
authors.initials: A
authors.lastname: Huertas-Vazquez
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Nelson
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Guo
authors.forename: Kyndaron
authors.initials: K
authors.lastname: Reinier
authors.forename: Audrey
authors.initials: A
authors.lastname: Uy-Evanado
authors.forename: Carmen
authors.initials: C
authors.lastname: Teodorescu
authors.forename: Jo
authors.initials: J
authors.lastname: Ayala
authors.forename: Katherine
authors.initials: K
authors.lastname: Jerger
authors.forename: Harpriya
authors.initials: H
authors.lastname: Chugh
authors.forename: Peter S
authors.initials: PS
authors.lastname: Braund
authors.forename: Panos
authors.initials: P
authors.lastname: Deloukas
authors.forename: Alistair S
authors.initials: AS
authors.lastname: Hall
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Balmforth
authors.forename: Michelle
authors.initials: M
authors.lastname: Jones
authors.forename: Kent D
authors.initials: KD
authors.lastname: Taylor
authors.forename: Sara L
authors.initials: SL
authors.lastname: Pulit
authors.forename: Christopher
authors.initials: C
authors.lastname: Newton-Cheh
authors.forename: Karen
authors.initials: K
authors.lastname: Gunson
authors.forename: Jonathan
authors.initials: J
authors.lastname: Jui
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.forename: Christine M
authors.initials: CM
authors.lastname: Albert
authors.forename: Nilesh J
authors.initials: NJ
authors.lastname: Samani
authors.forename: Sumeet S
authors.initials: SS
authors.lastname: Chugh
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000150:complications* / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006801:Humans; D007438:Introns; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D014157:Transcription Factors / Q000235:genetics*; D020692:rab3 GTP-Binding Proteins / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors; C475725:ZNF365 protein, human; C580955:RAB3GAP1 protein, human; D020692:rab3 GTP-Binding Proteins