title: Preparation and antimalarial activity of semisynthetic lycorenine derivatives.
abstract: A set of twenty one lycorenine derivatives has been prepared from the alkaloid hippeastrine (1). The modifications performed on hippeastrine included some functional group transformations, structural simplification and preparation of dimers. All alkaloids were tested as potential antimalarial agents, being the hippeastrine dimers the most active compounds.
authors.affiliation: Instituto Universitario de Bio-Orgánica "Antonio González", Av. Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Cedrón
authors.forename: David
authors.initials: D
authors.lastname: Gutiérrez
authors.forename: Ninoska
authors.initials: N
authors.lastname: Flores
authors.forename: Ángel G
authors.initials: ÁG
authors.lastname: Ravelo
authors.forename: Ana
authors.initials: A
authors.lastname: Estévez-Braun
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D019281:Dimerization; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D015394:Molecular Structure; D018512:Parasitemia / Q000469:parasitology / Q000517:prevention & control; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D047151:Amaryllidaceae Alkaloids; D000962:Antimalarials; C060577:hippeastrine; C023825:lycorenine