title: Influence of the molecular structure of surface-attached poly(N-alkyl acrylamide) coatings on the interaction of surfaces with proteins, cells and blood platelets.
abstract: Blood protein adsorption and blood platelet adhesion onto surface-attached poly(alkylacrylamide) networks that exhibit small and systematic variations in chemical composition are investigated. The polymer coatings are generated by depositing a thin layer of benzophenone-group-containing copolymer onto a solid substrate, followed by photo crosslinking and simultaneous surface-attachment. The correlation of the swelling of the obtained surface-attached networks with the adsorption of blood proteins and cellular adhesion is studied. The swollen surface-attached layers are inert to blood proteins and platelet cells. These results suggest that the hydrogel-coated materials are promising candidates for the generation of hemocompatible surfaces.
authors.affiliation: Laboratory for Chemistry and Physics of Interfaces, Department of Microsystems Engineering (IMTEK), University of Freiburg, 79110 Freiburg, Germany.
authors.forename: C K
authors.initials: CK
authors.lastname: Pandiyarajan
authors.forename: Oswald
authors.initials: O
authors.lastname: Prucker
authors.forename: Barbara
authors.initials: B
authors.lastname: Zieger
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rühe
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000327:Adsorption; D001792:Blood Platelets / Q000737:chemistry / Q000378:metabolism*; D002448:Cell Adhesion; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D015394:Molecular Structure; D010973:Platelet Adhesiveness; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D011506:Proteins; D013499:Surface Properties
chemical_list: D000178:Acrylamides; D020099:Coated Materials, Biocompatible; D011108:Polymers; D011506:Proteins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
keywords: cell adhesion; hemocompatibility; hydrogels; platelet adhesion; poly(N-alkyl acrylamide); protein adsorption; surface-attached network; swelling thrombus