title: Brain aging and mitochondria-targeted plastoquinone antioxidants of SkQ-type.
abstract: Normal brain aging leads to decrease in cognitive functions, shrink in brain volume, loss of nerve fibers and degenerating myelin, reduction in length and branching of dendrites, partial loss of synapses, and reduction in expression of genes that play central roles in synaptic plasticity, vesicular transport, and mitochondrial functioning. Impaired mitochondrial functions and mitochondrial reactive oxygen species can contribute to the damage of these genes in aging cerebral cortex. This review discusses the possibility of using mitochondria-targeted antioxidants to slow the processes of brain aging.
authors.affiliation: Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. isaev@genebee.msu.ru
authors.forename: N K
authors.initials: NK
authors.lastname: Isaev
authors.forename: E V
authors.initials: EV
authors.lastname: Stelmashook
authors.forename: N N
authors.initials: NN
authors.lastname: Stelmashook
authors.forename: I N
authors.initials: IN
authors.lastname: Sharonova
authors.forename: V G
authors.initials: VG
authors.lastname: Skrebitsky
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D010971:Plastoquinone / Q000031:analogs & derivatives / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D010971:Plastoquinone