title: Cooked common beans (Phaseolus vulgaris) protect against β-cell damage in streptozotocin-induced diabetic rats.
abstract: Diabetes is a disease characterized by a hyperglycemic stage that leads to a chronic inflammatory state. We evaluated the in vivo effect of a diet supplemented with 25 % cooked black bean cultivar Negro 8025 (N8025) flour in streptozotocin-induced diabetic rats. The effect was assessed before (preventive-treatment) and after (treatment) the onset of diabetes. There is a significant decrease of total phenolic, tannins and anthocyanins content after cooking, and the concentration of most of the single phenols analyzed are only slightly decreased. The treatment group showed a significant reduction of glucose (22.8 %), triglycerides (21.9 %), total cholesterol (29.9 %) and LDL (56.1 %) that correlates with a protection of pancreatic ß-cells. The diet with N8025 flour before the induction of diabetes did not exert a protective effect (glucose levels are similar to the diabetic control) but they have low levels of total cholesterol (47.5 %) and LDL (56.1 %). The preventive-treatment group did not inhibit the increase of TNF-α and IL-1β, whereas the treatment group did, compared to the diabetic control. Therefore, N8025 bean supplementation can be recommended to control diabetes.
authors.affiliation: Research and Graduate Studies in Food Science, School of Chemistry, UAQ, Santiago de Querétaro, Querétaro, México.
authors.forename: Diego
authors.initials: D
authors.lastname: Hernández-Saavedra
authors.forename: Magdalena
authors.initials: M
authors.lastname: Mendoza-Sánchez
authors.forename: Hebert L
authors.initials: HL
authors.lastname: Hernández-Montiel
authors.forename: Horacio S
authors.initials: HS
authors.lastname: Guzmán-Maldonado
authors.forename: Guadalupe F
authors.initials: GF
authors.lastname: Loarca-Piña
authors.forename: Luis M
authors.initials: LM
authors.lastname: Salgado
authors.forename: Rosalía
authors.initials: R
authors.lastname: Reynoso-Camacho
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000032:analysis; D002784:Cholesterol / Q000378:metabolism; D003296:Cooking; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D005947:Glucose / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology; D050417:Insulin-Secreting Cells / Q000187:drug effects*; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D027805:Phaseolus / Q000737:chemistry; D010636:Phenols / Q000032:analysis; D017208:Rats, Wistar; D013311:Streptozocin; D013634:Tannins / Q000032:analysis; D014280:Triglycerides / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000872:Anthocyanins; D007004:Hypoglycemic Agents; D010636:Phenols; D013634:Tannins; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D013311:Streptozocin; D002784:Cholesterol; D005947:Glucose