title: Involvement of serotoninergic and adrenergic systems on the antidepressant-like effect of E. uniflora L. leaves essential oil and further analysis of its antioxidant activity.
abstract: In this work we evaluated antidepressant-like effect of E. uniflora leaves EO employing the tail suspension test. The involvement of serotonergic and adrenergic systems was appraised. EO was administered by oral route (p.o.) in mice and the doses of 10 and 50mg/kg exhibited antidepressant-like action in the TST. The effect of EO (10mg/kg) was prevented by the pretreatment of mice with ketanserin (5mg/kg, intraperitoneal), prazosin (0.1mg/kg, i.p.) and yohimbine (0.1mg/kg, i.p.). In addition, further analysis of the in vitro antioxidant effect of the EO was made against lipid oxidation. The results revealed that EO has a potent antioxidant activity and therapeutic potential for the development of phytomedicines with antidepressant and antioxidant properties.
authors.affiliation: Programa de Pós-Graduação em Ciência e Tecnologia de Alimentos, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
authors.forename: Francine Novack
authors.initials: FN
authors.lastname: Victoria
authors.forename: Arthur
authors.initials: A
authors.lastname: de Siqueira Brahm
authors.forename: Lucielli
authors.initials: L
authors.lastname: Savegnago
authors.forename: Eder João
authors.initials: EJ
authors.lastname: Lenardão
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage; D000975:Antioxidants / Q000008:administration & dosage*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003863:Depression / Q000378:metabolism* / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009822:Oils, Volatile / Q000008:administration & dosage*; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000378:metabolism; D018490:Serotonin Agents / Q000008:administration & dosage*; D027842:Syzygium / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D000975:Antioxidants; D009822:Oils, Volatile; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D018490:Serotonin Agents