title: Gastrointestinal mucosal involvement without amyloidosis in children with familial Mediterranean fever.
abstract: OBJECTIVE
  Familial Mediterranean fever (FMF) and inflammatory bowel disease togetherness is well described in the literature. Abdominal pain and various gastrointestinal manifestations may arise directly from FMF or secondary to FMF-associated diseases such as inflammatory bowel disease, vasculitidies, or amyloidosis. The aim of the study was to document gastrointestinal involvement in familial Mediterranean fever.
  
  
  METHODS
  The medical files of the patients who were diagnosed as having FMF at the Department of Pediatric Gastroenterology, Gazi University School of Medicine between 2007 and 2012 were examined retrospectively. FMF diagnosis was made through performing clinical, laboratory, colonoscopy, endoscopy, and genetic analysis.
  
  
  RESULTS
  Thirty-six patients were diagnosed as having FMF during this period. Among them, 11 patients were admitted with vomiting or diarrhea. Colonoscopy and upper gastrointestinal endoscopy were performed. Colonic inflammation and multiple gastric aphthous ulcerations were observed.
  
  
  CONCLUSIONS
  In this report, we described 11 patients who presented with gastrointestinal symptoms and eventually diagnosed as having FMF. Gastrointestinal mucosal involvement without amyloidosis is documented by endoscopic and histopathologic investigations in these patients. We concluded that mucosal involvement of the gastrointestinal tract may be attack-related manifestations in these patients.
authors.affiliation: Department of Pediatric Gastroenterology, Gazi University School of Medicine, Ankara, Turkey. odulmd2003@yahoo.com
authors.forename: Odul Egritas
authors.initials: OE
authors.lastname: Gurkan
authors.forename: Buket
authors.initials: B
authors.lastname: Dalgic
mesh_terms: D000293:Adolescent; D000686:Amyloidosis; D002648:Child; D002675:Child, Preschool; D003092:Colitis / Q000209:etiology* / Q000235:genetics; D003106:Colon / Q000473:pathology*; D003967:Diarrhea / Q000209:etiology / Q000235:genetics; D010505:Familial Mediterranean Fever / Q000150:complications / Q000473:pathology*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005767:Gastrointestinal Diseases / Q000209:etiology* / Q000235:genetics; D005773:Gastroscopy; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D013272:Stomach Diseases / Q000209:etiology* / Q000235:genetics; D013281:Stomatitis, Aphthous / Q000209:etiology; D014839:Vomiting / Q000209:etiology / Q000235:genetics