title: Bone and lymph node metastases from neuroblastoma detected by 18F-DOPA-PET/CT and confirmed by posttherapy 131I-MIBG but negative on diagnostic 123I-MIBG scan.
abstract: We report the case of a 6-year-old child with stage 4 neuroblastoma, previously treated with chemotherapy, which relapsed in the right mandibular branch, right submandibular lymph nodes, and bone marrow. These sites of recurrence were detected on diagnostic (123)I-MIBG and confirmed by (18)F-DOPA-PET/CT, which revealed the following 2 additional sites of disease: in the skull base and the left supraclavicular lymph nodes. The patient was scheduled for radioiodine therapy and received a total dose of 7400 MBq (200 mCi) of (131)I-MIBG. The whole-body scan, acquired 72 hours later, revealed all sites of disease detected by (18)F-DOPA-PET/CT, including those negative on (123)I-MIBG scan.
authors.affiliation: From the *Nuclear Medicine Unit, Galliera Hospital, Genoa; †Nuclear Medicine Unit, Humanitas Hospital, Milan, Italy; ‡Medical and Pediatric Oncology Division, Hospital G. Gaslini, Genoa; and §PET/CT Center, IRMET, Turin, Italy.
authors.forename: Arnoldo
authors.initials: A
authors.lastname: Piccardo
authors.forename: Egesta
authors.initials: E
authors.lastname: Lopci
authors.forename: Massimo
authors.initials: M
authors.lastname: Conte
authors.forename: Manlio
authors.initials: M
authors.lastname: Cabria
authors.forename: Angelina
authors.initials: A
authors.lastname: Cistaro
authors.forename: Alberto
authors.initials: A
authors.lastname: Garaventa
authors.forename: Giampiero
authors.initials: G
authors.lastname: Villavecchia
mesh_terms: D019797:3-Iodobenzylguanidine; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary; D002648:Child; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D064847:Multimodal Imaging; D009447:Neuroblastoma / Q000473:pathology* / Q000628:therapy; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: C043437:fluorodopa F 18; D019797:3-Iodobenzylguanidine; D004295:Dihydroxyphenylalanine