title: Combined effect of mussel-inspired surface modification and topographical cues on the behavior of skeletal myoblasts.
abstract: The combined effect of mussel-inspired polydopamine (PDA) surface functionalization and topographical cues on the behavior of skeletal myoblasts is described. On PDA-modified nanofibers, myogenic protein expression and the fusion of myoblasts are increased significantly compared with those on unmodified nanofibers. The multinucleate myotubes on the aligned nanofibers are oriented in a direction parallel to the nanofibers.
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon 305-701, Republic of Korea.
authors.forename: Sook Hee
authors.initials: SH
authors.lastname: Ku
authors.forename: Chan Beum
authors.initials: CB
authors.lastname: Park
mesh_terms: D000818:Animals; D049872:Bivalvia / Q000737:chemistry*; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004298:Dopamine / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D051379:Mice; D018485:Muscle Fibers, Skeletal / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D032448:Myoblasts, Skeletal / Q000166:cytology* / Q000187:drug effects; D057139:Nanofibers / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000494:pharmacology; D013499:Surface Properties; D054457:Tissue Scaffolds
chemical_list: D007211:Indoles; D011091:Polyesters; D011108:Polymers; C568283:polydopamine; C016240:polycaprolactone; D004298:Dopamine
keywords: mussel adhesion; myogenic differentiation; nanofiber alignment; polydopamine; skeletal tissue engineering