title: [Endometriosis-associated ovarian cancers: pathogenesis and consequences on daily practice].
abstract: Endometriosis is considered as a tumor-like lesion under the World Health Organization (WHO) classification of ovarian tumors. Data from large cohort and case-control studies indicate that patients with a history of endometriosis have an increased risk of ovarian cancer. Recent findings suggest an association between endometriosis and the entire type 1 ovarian tumors group including clear-cell, endometrioid and low-grade serous carcinomas. However, current evidence is lacking to draw definitive conclusion whether this association represents causality or the sharing of common risk factors. Nevertheless, assumption that endometriosis could be a precursor of malignancy raises many issues about serial screening, surgical management and surveillance of endometriosis. Beyond these concerns, endometriosis-associated ovarian cancers seem to be a genuine clinical entity as regards clinicopathological features. In view of the high incidence of endometriosis (10 % of women of childbearing age), the low incidence of endometriosis-associated ovarian cancers and the psychological consequences for those women, systematic screening and surgical exploration seem very questionable in this context.
authors.affiliation: Service de gynécologie obstétrique 2 et médecine de la reproduction, université Paris Descartes, Sorbonne Paris Cité, groupe hospitalier Cochin Broca Hôtel-Dieu, Assistance publique-hôpitaux de Paris, 75014 Paris, France. bruno.borghese@cch.aphp.fr
authors.forename: B
authors.initials: B
authors.lastname: Borghese
authors.forename: P
authors.initials: P
authors.lastname: Santulli
authors.forename: D
authors.initials: D
authors.lastname: Vaiman
authors.forename: J
authors.initials: J
authors.lastname: Alexandre
authors.forename: F
authors.initials: F
authors.lastname: Goldwasser
authors.forename: C
authors.initials: C
authors.lastname: Chapron
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics; D018450:Disease Progression; D004715:Endometriosis / Q000150:complications* / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D011364:Professional Practice; D011379:Prognosis