title: Sister chromatid segregation in meiosis II: deprotection through phosphorylation.
abstract: Meiotic divisions (meiosis I and II) are specialized cell divisions to generate haploid gametes. The first meiotic division with the separation of chromosomes is named reductional division. The second division, which takes place immediately after meiosis I without intervening S-phase, is equational, with the separation of sister chromatids, similar to mitosis. This meiotic segregation pattern requires the two-step removal of the cohesin complex holding sister chromatids together: cohesin is removed from chromosome arms that have been subjected to homologous recombination in meiosis I and from the centromere region in meiosis II. Cohesin in the centromere region is protected from removal in meiosis I, but this protection has to be removed--deprotected--for sister chromatid segregation in meiosis II. Whereas the mechanisms of cohesin protection are quite well understood, the mechanisms of deprotection have been largely unknown until recently. In this review I summarize our current knowledge on cohesin deprotection.
authors.affiliation: UPMC University of Paris 6, Paris, France. katja.wassmann@snv.jussieu.fr
authors.forename: Katja
authors.initials: K
authors.lastname: Wassmann
mesh_terms: D000818:Animals; D002503:Centromere / Q000378:metabolism; D002842:Chromatids / Q000378:metabolism*; D020090:Chromosome Segregation; D006801:Humans; D008540:Meiosis; D008954:Models, Biological; D010766:Phosphorylation
keywords: I2PP2A/Set; PP2A; Rec8; cohesin deprotection; cohesin protection; cyclin A; meiosis; oocytes; separase; shugoshin