title: Chordoid meningioma: a retrospective series of seven consecutive cases.
abstract: Chordoid meningioma is a rare variant of meningioma characterized by a more aggressive behavior. The present study documents the histological, radiological and clinical features of seven cases treated at the Policlinico Umberto I of Rome from 1999 to 2010. There were five males and two females. Most of the cases were located in the supratentorial space, especially the convexity. Surgical gross total resection was achieved in four cases. Of the remaining three cases, two relapsed and underwent further surgeries and adjuvant treatment. The MIB-1 index had a mean value of 7.5 (range 0.3-25.8). Tumors were composed of epithelioid cells or plump to spindle cells, forming cords, cribriforms or nests, in a mucoid matrix. All tumors showed diffuse positive immunoreactivity to vimentin and epithelial membrane antigen. Surgery is the first line of treatment for this kind of lesion. Gross total resection guaranteed a survival free from recurrences in our series. On the other hand, radiation therapy must be considered in patients submitted to a subtotal resection.
authors.affiliation: Department of Neurology and Psychiatry, Neurosurgery, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Emiliano
authors.initials: E
authors.lastname: Passacantilli
authors.forename: Gennaro
authors.initials: G
authors.lastname: Lapadula
authors.forename: Federico
authors.initials: F
authors.lastname: Caporlingua
authors.forename: Jacopo
authors.initials: J
authors.lastname: Lenzi
authors.forename: Manila
authors.initials: M
authors.lastname: Antonelli
authors.forename: Francesca
authors.initials: F
authors.lastname: Santoro
authors.forename: Antonio
authors.initials: A
authors.lastname: Santoro
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis*; D008579:Meningioma / Q000175:diagnosis*; D008875:Middle Aged; D012189:Retrospective Studies