title: Vasopressin and the regulation of aquaporin-2.
abstract: Water excretion is regulated in large part through the regulation of osmotic water permeability of the renal collecting duct epithelium. Water permeability is controlled by vasopressin through regulation of the water channel, aquaporin-2 (AQP2). Two processes contribute: (1) regulation of AQP2 trafficking to the apical plasma membrane; and (2) regulation of the total amount of the AQP2 protein in the cells. Regulation of AQP2 abundance is defective in several water-balance disorders, including many polyuric disorders and the syndrome of inappropriate antidiuresis. Here we review vasopressin signaling in the renal collecting duct that is relevant to the two modes of water permeability regulation.
authors.affiliation: Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr., Bldg 10, Room 6N260, Bethesda, MD, 20892-1603, USA.
authors.forename: Justin L L
authors.initials: JL
authors.lastname: Wilson
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Miranda
authors.forename: Mark A
authors.initials: MA
authors.lastname: Knepper
mesh_terms: D000818:Animals; D051399:Aquaporin 2 / Q000096:biosynthesis / Q000378:metabolism*; D000242:Cyclic AMP / Q000502:physiology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000503:physiopathology; D007685:Kidney Tubules, Collecting / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000503:physiopathology; D051379:Mice; D009219:Myosin-Light-Chain Kinase / Q000378:metabolism; D009404:Nephrotic Syndrome / Q000503:physiopathology; D010539:Permeability; D010750:Phosphoproteins / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D011141:Polyuria / Q000503:physiopathology; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction / Q000502:physiology; D018808:Transcription Factor AP-1 / Q000378:metabolism; D014157:Transcription Factors / Q000502:physiology; D014667:Vasopressins / Q000502:physiology*; D051176:beta Catenin / Q000378:metabolism
chemical_list: D051399:Aquaporin 2; D010750:Phosphoproteins; D016755:Proto-Oncogene Proteins c-jun; D018808:Transcription Factor AP-1; D014157:Transcription Factors; D051176:beta Catenin; D014667:Vasopressins; D000242:Cyclic AMP; D051057:Proto-Oncogene Proteins c-akt; D017868:Cyclic AMP-Dependent Protein Kinases; D009219:Myosin-Light-Chain Kinase