title: An update on pharmacologic approaches to bronchopulmonary dysplasia.
abstract: Bronchopulmonary dysplasia (BPD) is the most prevalent long-term morbidity in surviving extremely preterm infants and is linked to increased risk of reactive airways disease, pulmonary hypertension, post-neonatal mortality, and adverse neurodevelopmental outcomes. BPD affects approximately 20% of premature newborns, and up to 60% of premature infants born before completing 26 weeks of gestation. It is characterized by the need for assisted ventilation and/or supplemental oxygen at 36 weeks postmenstrual age. Approaches to prevention and treatment of BPD have evolved with improved understanding of its pathogenesis. This review will focus on recent advancements and detail current research in pharmacotherapy for BPD. The evidence for both current and potential future experimental therapies will be reviewed in detail. As our understanding of the complex and multifactorial pathophysiology of BPD changes, research into these current and future approaches must continue to evolve.
authors.affiliation: Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Sailaja
authors.initials: S
authors.lastname: Ghanta
authors.forename: Kristen Tropea
authors.initials: KT
authors.lastname: Leeman
authors.forename: Helen
authors.initials: H
authors.lastname: Christou
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001993:Bronchodilator Agents / Q000627:therapeutic use; D001997:Bronchopulmonary Dysplasia / Q000188:drug therapy* / Q000517:prevention & control; D004232:Diuretics / Q000627:therapeutic use; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D014801:Vitamin A / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use; D014970:Xanthines / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D001993:Bronchodilator Agents; D004232:Diuretics; D011663:Pulmonary Surfactants; D014815:Vitamins; D014970:Xanthines; D014801:Vitamin A