title: Identification of a novel HLA-B*27 allele, B*27:79 and the B*27 subtype polymorphism in the Hunan ethnic Han population of China.
abstract: This article describes a novel HLA-B*27 allele, HLA-B*27:79, which was identified in a Hunan Han ethnic individual of China by a PCR sequence-based typing method. The new sequence has one nucleotide mutation at position 437(A→T) compared with the allele B*27:04:01. This nucleotide change causes an amino acid substitution from Aspartate (Asp) to Valine (Val) at codon 122. This is the first report of mutation at this position in the HLA-B locus. Then, we investigated the HLA-B*27 subtype polymorphism of the Hunan Han population, and the results showed that B*27:04, B*27:05 and B*27:06 are the predominant subtypes with the allele frequencies 0.97%, 0.26% and 0.10% respectively.
authors.affiliation: Changsha Blood Center, Changsha, Hunan Province, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Xie
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: Z
authors.initials: Z
authors.lastname: Zuo
authors.forename: G
authors.initials: G
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Cao
authors.forename: T
authors.initials: T
authors.lastname: Li
mesh_terms: D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D060005:Genotyping Techniques / Q000379:methods*; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D015796:HLA-B27 Antigen