title: A new biological approach to guided bone and tissue regeneration.
abstract: The purpose of this study was to determine the potential of platelet-rich fibrin (PRF) membranes used for guided bone and tissue regeneration. A patient with insufficient alveolar ridge width in aesthetic zone was enrolled. The patient's blood was centrifuged to obtain PRF membranes. Autogenous bone graft was mixed with bovine hydroxyapatite, PRF particles and applied to fill the defect. Five PRF membranes were placed over the bone mix. After 4 months a cone-beam CT was performed to evaluate bone regeneration. The use of PRF as cover membrane permitted a rapid epithelisation and represented an effective barrier versus epithelial cell penetration. After 4 months the site appeared precociously healed and the bone volume increased. This new approach represents a predictable method of augmenting deficient alveolar ridges. Guided bone regeneration with PRF showed limitation compared with guided bone regeneration using collagen membrane in terms of bone gain. The association of collagen membrane and PRF could be a good association.
authors.affiliation: Unit of Dentistry for Special Care, Department of Oral Science, University of Bologna, Bologna, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Montanari
authors.forename: Michele
authors.initials: M
authors.lastname: Callea
authors.forename: Izzet
authors.initials: I
authors.lastname: Yavuz
authors.forename: Michele
authors.initials: M
authors.lastname: Maglione
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001792:Blood Platelets / Q000737:chemistry*; D001861:Bone Regeneration; D003758:Dental Implantation, Endosseous; D017886:Durapatite / Q000627:therapeutic use; D005337:Fibrin / Q000627:therapeutic use*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans
chemical_list: D005337:Fibrin; D017886:Durapatite