title: Iridoid and bis-iridoid glucosides from the fruit of Gardenia jasminoides.
abstract: Three new iridoid glucosides, 6″-O-trans-feruloylgenipin gentiobioside (1), 2'-O-trans-caffeoylgardoside (2), jasmigeniposide A (3), and one new bis-iridoid glucoside, jasmigeniposide B (4), along with six known analogues (5-10), were isolated from the fruit of Gardenia jasminoides. Their structures were established on the basis of spectroscopic analyses and chemical methods. Anti-virus activity of isolated compounds were evaluated in vitro and only compound 9 showed moderate inhibitory activity against H1N1 with 50% effective concentration (EC50) value of 104.36 μM, and selective index (SI) value greater than 4.79.
authors.affiliation: Nanjing University of Chinese Medicine, Nanjing 210000, PR China.
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Li
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Jiangsu Kanion Pharmaceutical, Lianyungang 222000, PR China.
authors.forename: Zhen-Zhong
authors.initials: ZZ
authors.lastname: Wang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.affiliation: Nanjing University of Chinese Medicine, Nanjing 210000, PR China; Jiangsu Kanion Pharmaceutical, Lianyungang 222000, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Shenyang Pharmqaceutical University, Shenyang 110016, PR China. Electronic address: tyaoxs@jnu.edu.cn.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D032062:Gardenia / Q000737:chemistry*; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D057888:Iridoid Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D057888:Iridoid Glucosides; D010936:Plant Extracts
keywords: Anti-influenza virus; Bis-iridoid; EV-71; Gardenia jasminoides; H1N1; H3N2; Iridoid glucoside