title: Hepatoprotective activity of Hepax-a polyherbal formulation.
abstract: OBJECTIVE
  To evaluate the hepatoprotective potential of Hepax, a polyherbal formulation, against three experimentally induced hepatotoxicity models in rats.
  
  
  METHODS
  Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models, namely, carbon tetrachloride (CCl4), paracetamol and thiocetamide induced hepatotoxicity in rats.
  
  
  RESULTS
  Administration of hepatotoxins (CCl4, paracetamol and thiocetamide) showed significant morphological, biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters (liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters (SGPT, SGOT, ALP and total bilirubin), which were evidently showed in histopathological study.
  
  
  CONCLUSIONS
  The Hepax has highly significant hepatoprotective effect at 100 and 200 mg/kg, p.o. on the liver of all the three experimental animal models.
authors.affiliation: Department of Pharmacology, Krupanidhi College of Pharmacy, Bangalore, India.
authors.forename: V C
authors.initials: VC
authors.lastname: Devaraj
authors.forename: B Gopala
authors.initials: BG
authors.lastname: Krishna
authors.forename: G L
authors.initials: GL
authors.lastname: Viswanatha
authors.forename: Jagadish V
authors.initials: JV
authors.lastname: Kamath
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects; D000818:Animals; D002251:Carbon Tetrachloride / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007194:India; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D010946:Plants, Medicinal / Q000737:chemistry*; D020011:Protective Agents / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D000082:Acetaminophen; D002251:Carbon Tetrachloride
keywords: CCl4; Hepatotoxicity; Hepax; Paracetamol; Thiocetamide