title: Vulvar atypical granular cell tumor in a preadolescent patient.
abstract: BACKGROUND
  Granular cell tumor is an uncommon benign neoplasm with a predisposition for upper aerodigestive tract, skin and soft tissue involvement. Malignant and atypical granular cell tumors account for less than 2% of the lesions and in the pediatric population they are extremely rare and atypia has not been previously reported.
  
  
  METHODS
  We present a case of a rapidly growing granular cell tumor of the vulva of a 12-year-old girl exhibiting atypical histology. The lesion demonstrated prominent Ki-67 proliferation index (up to 20%), localized areas of spindling of tumor cells, scattered apoptotic bodies and p53 overexpression.
  
  
  CONCLUSIONS
  The current histologic diagnostic criteria of atypical granular cell tumors are evaluated while physician awareness and the need for follow-up of patients for potential recurrences of this rare entity are emphasized.
authors.affiliation: Department of Pathology, Women and Children's Hospital of Buffalo, School of Medicine and Biological Sciences, The State University of New York at Buffalo, Buffalo, NY 14203, USA. asangiku@buffalo.edu
authors.forename: Asangi R
authors.initials: AR
authors.lastname: Kumarapeli
authors.forename: Rafal
authors.initials: R
authors.lastname: Kozielski
mesh_terms: D002648:Child; D005260:Female; D016586:Granular Cell Tumor / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D014846:Vulvar Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53