title: Auditory profile and high resolution CT scan in autism spectrum disorders children with auditory hypersensitivity.
abstract: Autism is the third most common developmental disorder, following mental retardationand cerebral palsy. ASD children have been described more often as beingpreoccupied with or agitated by noise. The aim of this study was to evaluate theprevalence and clinical significance of semicircular canal dehiscence detected on CTimages in ASD children with intolerance to loud sounds in an attempt to find ananatomical correlate with hyperacusis.14 ASD children with auditory hypersensitivity and 15 ASD children without auditoryhypersensitivity as control group age and gender matched were submitted to historytaking, otological examination, tympanometry and acoustic reflex thresholdmeasurement. ABR was done to validate normal peripheral hearing and integrity ofauditory brain stem pathway. High resolution CT scan petrous and temporal boneimaging was performed to all participated children. All participants had normal hearingsensitivity in ABR testing. Absolute ABR peak waves of I and III showed no statisticallysignificant difference between the two groups, while absolute wave V peak andinterpeak latencies I-V and III-V were shorter in duration in study group whencompared to the control group. CT scans revealed SSCD in 4 out of 14 of the studygroup (29%), the dehiscence was bilateral in one patient and unilateral in threepatients. None of control group showed SSCD. In conclusion, we have reportedevidence that apparent hypersensitivity to auditory stimuli (short conduction time in ABR) despite the normal physiological measures in ASD children with auditoryhypersensitivity can provide a clinical clue of a possible SSCD.
authors.affiliation: Audiology Unit, ENT-HNS Department, College of Medicine, Mansoura University, 60 El Gomhuria St., Mansoura 35516, Egypt. saeed_thabet@hotmail.com
authors.forename: Elsaeid M
authors.initials: EM
authors.lastname: Thabet
authors.forename: Hesham S
authors.initials: HS
authors.lastname: Zaghloul
mesh_terms: D001299:Audiometry; D001309:Auditory Threshold; D016022:Case-Control Studies; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000150:complications* / Q000000981:diagnostic imaging; D002675:Child, Preschool; D004424:Ear Canal / Q000000981:diagnostic imaging / Q000473:pathology*; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006801:Humans; D012001:Hyperacusis / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D013701:Temporal Bone / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*