title: Gene entropy-fractal dimension informatics with application to mouse-human translational medicine.
abstract: DNA informatics represented by Shannon entropy and fractal dimension have been used to form 2D maps of related genes in various mammals. The distance between points on these maps for corresponding mRNA sequences in different species is used to study evolution. By quantifying the similarity of genes between species, this distance might be indicated when studies on one species (mouse) would tend to be valid in the other (human). The hypothesis that a small distance from mouse to human could facilitate mouse to human translational medicine success is supported by the studied ESR-1, LMNA, Myc, and RNF4 sequences. ID1 and PLCZ1 have larger separation. The collinearity of displacement vectors is further analyzed with a regression model, and the ID1 result suggests a mouse-chimp-human translational medicine approach. Further inference was found in the tumor suppression gene, p53, with a new hypothesis of including the bovine PKM2 pathways for targeting the glycolysis preference in many types of cancerous cells, consistent with quantum metabolism models. The distance between mRNA and protein coding CDS is proposed as a measure of the pressure associated with noncoding processes. The Y-chromosome DYS14 in fetal micro chimerism that could offer protection from Alzheimer's disease is given as an example.
authors.affiliation: Queensborough Community College of CUNY, 222-05 56th Avenve Bayside, NY 11364, USA. tholden@qcc.cuny.edu
authors.forename: T
authors.initials: T
authors.lastname: Holden
authors.forename: E
authors.initials: E
authors.lastname: Cheung
authors.forename: S
authors.initials: S
authors.lastname: Dehipawala
authors.forename: J
authors.initials: J
authors.lastname: Ye
authors.forename: G
authors.initials: G
authors.lastname: Tremberger
authors.forename: D
authors.initials: D
authors.lastname: Lieberman
authors.forename: T
authors.initials: T
authors.lastname: Cheung
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D019277:Entropy; D019143:Evolution, Molecular; D017709:Fractals; D006801:Humans; D008490:Medical Informatics; D051379:Mice; D008957:Models, Genetic; D012333:RNA, Messenger / Q000235:genetics; D057170:Translational Research, Biomedical; D014998:Y Chromosome / Q000235:genetics*
chemical_list: D012333:RNA, Messenger