title: Panta rhei: the APC/C at steady state.
abstract: The anaphase-promoting complex or cyclosome (APC/C) is a conserved, multisubunit E3 ubiquitin (Ub) ligase that is active both in dividing and in postmitotic cells. Its contributions to life are especially well studied in the domain of cell division, in which the APC/C lies at the epicenter of a regulatory network that controls the directionality and timing of cell cycle events. Biochemical and structural work is shedding light on the overall organization of APC/C subunits and on the mechanism of substrate recognition and Ub chain initiation and extension as well as on the molecular mechanisms of a checkpoint that seizes control of APC/C activity during mitosis. Here, we review how these recent advancements are modifying our understanding of the APC/C.
authors.affiliation: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
authors.forename: Ivana
authors.initials: I
authors.lastname: Primorac
authors.forename: Andrea
authors.initials: A
authors.lastname: Musacchio
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D059447:Cell Cycle Checkpoints; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D013379:Substrate Specificity; D025801:Ubiquitin / Q000378:metabolism; D043743:Ubiquitin-Protein Ligase Complexes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D025801:Ubiquitin; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome