title: Organocatalytic formal [2+2] cycloaddition initiated by vinylogous Friedel-Crafts alkylation: enantioselective synthesis of substituted cyclobutane derivatives.
abstract: An organocatalytic vinylogous Friedel-Crafts alkylation-initiated formal [2+2] cycloaddition was successfully developed based on tandem iminium-enamine activation of enals. Transformable pyrrole-functionalized cyclobutanes with three contiguous stereocenters were readily obtained with excellent levels of regio-, diastereo- and enantiocontrol.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Guo-Jian
authors.initials: GJ
authors.lastname: Duan
authors.forename: Jun-Bing
authors.initials: JB
authors.lastname: Ling
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Wang
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Luo
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Xu
mesh_terms: D000171:Acrolein / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D000478:Alkylation; D002384:Catalysis; D061565:Cycloaddition Reaction; D003503:Cyclobutanes / Q000138:chemical synthesis / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D003503:Cyclobutanes; D007211:Indoles; D000171:Acrolein; C030374:indole