title: A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI.
abstract: A europium(III) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen ((1)O2). The water soluble, thermodynamically stable complex reacts rapidly with (1)O2 to form an endoperoxide derivative that results in an ∼3 ppm shift in the position of the Eu(III)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.
authors.affiliation: Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Song
authors.forename: Yunkou
authors.initials: Y
authors.lastname: Wu
authors.forename: Mengxiao
authors.initials: M
authors.lastname: Yu
authors.forename: Piyu
authors.initials: P
authors.lastname: Zhao
authors.forename: Chen
authors.initials: C
authors.lastname: Zhou
authors.forename: Garry E
authors.initials: GE
authors.lastname: Kiefer
authors.forename: A Dean
authors.initials: AD
authors.lastname: Sherry
mesh_terms: D000577:Amides / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D006367:HeLa Cells; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D026082:Singlet Oxygen / Q000032:analysis*
chemical_list: D000577:Amides; D003287:Contrast Media; D006573:Heterocyclic Compounds, 1-Ring; D026082:Singlet Oxygen; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D005063:Europium