title: Triggered drug release from superhydrophobic meshes using high-intensity focused ultrasound.
abstract: Application of high-intensity focused ultrasound to drug-loaded superhydrophobic meshes affords triggered drug release by displacing an entrapped air layer. The air layer within the superhydrophobic meshes is characterized using direct visualization and B-mode imaging. Drug-loaded superhydrophobic meshes are cytotoxic in an in vitro assay after ultrasound treatment.
authors.affiliation: Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA 02215.
authors.forename: Stefan T
authors.initials: ST
authors.lastname: Yohe
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Kopechek
authors.forename: Tyrone M
authors.initials: TM
authors.lastname: Porter
authors.forename: Yolonda L
authors.initials: YL
authors.lastname: Colson
authors.forename: Mark W
authors.initials: MW
authors.lastname: Grinstaff
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000633:toxicity; D002166:Camptothecin / Q000031:analogs & derivatives / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D000077146:Irinotecan; D061986:MCF-7 Cells; D011091:Polyesters / Q000737:chemistry; D014465:Ultrasonics
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D011091:Polyesters; C552306:poly(glycerol monosterate-co-epsilon-caprolactone); C016240:polycaprolactone; D000077146:Irinotecan; D002166:Camptothecin
keywords: HIFU; biomaterials; drug delivery; electrospinning; meshes; superhydrophobic; triggered; ultrasound