title: Antibacterial efficacy of the seed extracts of Melia azedarach against some hospital isolated human pathogenic bacterial strains.
abstract: OBJECTIVE
  To investigate the antibacterial potential of the polar and non-polar extracts of the seeds of Melia azedarach (M. azedarach) L. (Meliaceae) against eighteen hospital isolated human pathogenic bacterial strains.
  
  
  METHODS
  Petrol, benzene, ethyl acetate, methanol, and aqueous extracts at five different concentrations (1, 2, 5, 10 and 15 mg/mL) were evaluated. Disk diffusion method was followed to evaluate the antibacterial efficacy.
  
  
  RESULTS
  All extracts of the seeds demonstrated significant antibacterial activity against tested pathogens. Among all extracts, ethyl acetate extract revealed the highest inhibition comparatively. The present study also favored the traditional uses reported earlier.
  
  
  CONCLUSIONS
  Results of this study strongly confirm that the seed extracts of M. azedarach could be effective antibiotics, both in controlling gram-positive and gram-negative human pathogenic infections.
authors.affiliation: Department of Botany, Faculty of Life Sciences, Aligarh Muslim University, Aligarh-202002, State of Utter Pradesh, India.
authors.forename: Abdul Viqar
authors.initials: AV
authors.lastname: Khan
authors.forename: Qamar Uddin
authors.initials: QU
authors.lastname: Ahmed
authors.forename: M Ramzan
authors.initials: MR
authors.lastname: Mir
authors.forename: Indu
authors.initials: I
authors.lastname: Shukla
authors.forename: Athar Ali
authors.initials: AA
authors.lastname: Khan
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000382:microbiology; D003428:Cross Infection / Q000382:microbiology; D006801:Humans; D031586:Melia azedarach / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts
keywords: Antibacterial efficacy; Melia azedarach; Pathogenic bacteria