title: Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
abstract: We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up replication analyses in 876 cases and 1,890 controls. We confirmed association with TERT at 5p15, MUC5B at 11p15 and the 3q26 region near TERC, and we identified seven newly associated loci (Pmeta = 2.4 × 10(-8) to 1.1 × 10(-19)), including FAM13A (4q22), DSP (6p24), OBFC1 (10q24), ATP11A (13q34), DPP9 (19p13) and chromosomal regions 7q22 and 15q14-15. Our results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs.
authors.affiliation: University of Colorado Denver, School of Public Health, Denver, Colorado, USA.
authors.forename: Tasha E
authors.initials: TE
authors.lastname: Fingerlin
authors.forename: Elissa
authors.initials: E
authors.lastname: Murphy
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhang
authors.forename: Anna L
authors.initials: AL
authors.lastname: Peljto
authors.forename: Kevin K
authors.initials: KK
authors.lastname: Brown
authors.forename: Mark P
authors.initials: MP
authors.lastname: Steele
authors.forename: James E
authors.initials: JE
authors.lastname: Loyd
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Cosgrove
authors.forename: David
authors.initials: D
authors.lastname: Lynch
authors.forename: Steve
authors.initials: S
authors.lastname: Groshong
authors.forename: Harold R
authors.initials: HR
authors.lastname: Collard
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Wolters
authors.forename: Williamson Z
authors.initials: WZ
authors.lastname: Bradford
authors.forename: Karl
authors.initials: K
authors.lastname: Kossen
authors.forename: Scott D
authors.initials: SD
authors.lastname: Seiwert
authors.forename: Roland M
authors.initials: RM
authors.lastname: du Bois
authors.forename: Christine Kim
authors.initials: CK
authors.lastname: Garcia
authors.forename: Megan S
authors.initials: MS
authors.lastname: Devine
authors.forename: Gunnar
authors.initials: G
authors.lastname: Gudmundsson
authors.forename: Helgi J
authors.initials: HJ
authors.lastname: Isaksson
authors.forename: Naftali
authors.initials: N
authors.lastname: Kaminski
authors.forename: Yingze
authors.initials: Y
authors.lastname: Zhang
authors.forename: Kevin F
authors.initials: KF
authors.lastname: Gibson
authors.forename: Lisa H
authors.initials: LH
authors.lastname: Lancaster
authors.forename: Joy D
authors.initials: JD
authors.lastname: Cogan
authors.forename: Wendi R
authors.initials: WR
authors.lastname: Mason
authors.forename: Toby M
authors.initials: TM
authors.lastname: Maher
authors.forename: Philip L
authors.initials: PL
authors.lastname: Molyneaux
authors.forename: Athol U
authors.initials: AU
authors.lastname: Wells
authors.forename: Miriam F
authors.initials: MF
authors.lastname: Moffatt
authors.forename: Moises
authors.initials: M
authors.lastname: Selman
authors.forename: Annie
authors.initials: A
authors.lastname: Pardo
authors.forename: Dong Soon
authors.initials: DS
authors.lastname: Kim
authors.forename: James D
authors.initials: JD
authors.lastname: Crapo
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Make
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Regan
authors.forename: Dinesha S
authors.initials: DS
authors.lastname: Walek
authors.forename: Jerry J
authors.initials: JJ
authors.lastname: Daniel
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kamatani
authors.forename: Diana
authors.initials: D
authors.lastname: Zelenika
authors.forename: Keith
authors.initials: K
authors.lastname: Smith
authors.forename: David
authors.initials: D
authors.lastname: McKean
authors.forename: Brent S
authors.initials: BS
authors.lastname: Pedersen
authors.forename: Janet
authors.initials: J
authors.lastname: Talbert
authors.forename: Raven N
authors.initials: RN
authors.lastname: Kidd
authors.forename: Cheryl R
authors.initials: CR
authors.lastname: Markin
authors.forename: Kenneth B
authors.initials: KB
authors.lastname: Beckman
authors.forename: Mark
authors.initials: M
authors.lastname: Lathrop
authors.forename: Marvin I
authors.initials: MI
authors.lastname: Schwarz
authors.forename: David A
authors.initials: DA
authors.lastname: Schwartz
mesh_terms: D016022:Case-Control Studies; D002877:Chromosomes, Human; D015870:Gene Expression; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000235:genetics*; D008168:Lung / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA