title: Use of fibrin sealants in cardiovascular surgery: a systematic review.
abstract: BACKGROUND
  Fibrin sealants are used for hemostasis and tissue adherence.
  
  
  OBJECTIVE
  This systematic review summarizes published clinical data for fibrin sealant use in cardiovascular surgery.
  
  
  METHODS
  A literature search for the following terms was conducted using PubMed and EMBASE: (TISSEEL or Tissucol or Beriplast P or Evicel or Quixil or Crosseal or Reliseal or Fibringluraas or Bolheal or Tachosil or Vivostat or Vitagel or Artiss or "fibrin glue" or "fibrin sealant" or "fibrin tissue adhesive") and (cardiac or cardiovascular or vascular or heart or coronary or surgery). Case reports and series were excluded; although reports of controlled trials were preferred, uncontrolled trial data were also considered.
  
  
  RESULTS
  Clinical trials and chart review analyses of fibrin sealants were identified and summarized. Although clinical trial data were available for other agents, the majority of published studies examined TISSEEL. Overall, TISSEEL and other fibrin sealants showed improvements over standard of care or control groups for a variety of predefined endpoints. Safety findings are also summarized.
  
  
  CONCLUSIONS
  Data from these studies showed that fibrin sealants were well tolerated and provided effective hemostasis in a range of cardiac and aortic surgeries.
authors.affiliation: Division of Cardiac Surgery, Baystate Medical Center, Springfield, Massachusetts 01107, USA. jrousou@comcast.net
authors.forename: John A
authors.initials: JA
authors.lastname: Rousou
mesh_terms: D002318:Cardiovascular Diseases / Q000601:surgery*; D004311:Double-Blind Method; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic
chemical_list: D015718:Fibrin Tissue Adhesive