title: Virtual couch shift (VCS): accounting for patient translation and rotation by online IMRT re-optimization.
abstract: When delivering conventional intensity modulated radiotherapy (IMRT), discrepancies between the pre-treatment CT/MRI/PET based patient geometry and the daily patient geometry are minimized by performing couch translations and/or small rotations. However, full compensation of, in particular, rotations is usually not possible. In this paper, we introduce an online 'virtual couch shift (VCS)': we translate and/or rotate the pre-treatment dose distribution to compensate for the changes in patient anatomy and generate a new plan which delivers the transformed dose distribution automatically. We show for a phantom and a cervical cancer patient case that VCS accounts for both translations and large rotations equally well in terms of DVH results and 2%/2 mm γ analyses and when the various aspects of the clinical workflow can be implemented successfully, VCS can potentially outperform physical couch translations and/or rotations. This work is performed in the context of our hybrid 1.5 T MRI linear accelerator, which can provide translations and rotations but also deformations of the anatomy. The VCS is the first step toward compensating all of these anatomical changes by online re-optimization of the IMRT dose distribution.
authors.affiliation: Department of Radiotherapy, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. g.h.bol@umcutrecht.nl
authors.forename: G H
authors.initials: GH
authors.lastname: Bol
authors.forename: J J W
authors.initials: JJ
authors.lastname: Lagendijk
authors.forename: B W
authors.initials: BW
authors.lastname: Raaymakers
mesh_terms: D000465:Algorithms; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D058958:Organs at Risk / Q000528:radiation effects; D019047:Phantoms, Imaging; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods*; D012399:Rotation; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy