title: [High risk of strongyloïdes hyperinfection in a patient with sarcoidosis].
abstract: Strongyloïdes stercoralis infection is a polymorphic and non specific clinical presentation. Often asymptomatic, it can be not seen. However, in patients with immunodeficiency, high parasite load can be observed, consequence of self-infestation cycle, and can spread throughout the body. This presentation of malignant strongyloidiasis presents a mortality rate of 70%. The case report presents a 45 years old patient of Caribbean origin, long time treated with corticosteroids for sarcoidosis, and hospitalized for Strongyloïdes stercoralis colitis with high parasite load, raising fears an evolution to hyperinfection. His last visit to endemic area was in 2002. In conclusion, the potential severity of strongyloidiasis is strongly increased by immunosuppression, including corticosteroids. This risk should be notified prior to initiation of any treatment with corticosteroids, firstly by looking at a stay in endemic areas. The case of our patient illustrates the fact that a long time between risk of contamination and clinical manifestations is not a sufficient criterion for excluding an asymptomatic chronic infection with Strongyloïdes stercoralis. It is therefore recommended for patients who have lived in endemic areas to search the parasite in stool by a sensitive method.
authors.affiliation: Service de parasitologie-mycologie, CHU de Nancy, Hôpitaux de Brabois, Vandœuvre-les-Nancy, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Perez
authors.forename: Anne
authors.initials: A
authors.lastname: Debourgogne
authors.forename: Thomas
authors.initials: T
authors.lastname: Valloton
authors.forename: Abdelbasset
authors.initials: A
authors.lastname: Nani
authors.forename: Hélène
authors.initials: H
authors.lastname: Barraud
authors.forename: Marie
authors.initials: M
authors.lastname: Machouart
mesh_terms: D000818:Animals; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012507:Sarcoidosis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000469:parasitology; D017171:Strongyloides stercoralis / Q000254:growth & development / Q000276:immunology / Q000502:physiology*; D013322:Strongyloidiasis / Q000150:complications / Q000209:etiology* / Q000276:immunology; D015163:Superinfection / Q000139:chemically induced / Q000209:etiology* / Q000276:immunology / Q000469:parasitology
keywords: Strongyloïdes stercoralis; anguillolosis; sarcoidosis