title: Impact of estradiol valerate/dienogest on work productivity and activities of daily living in women with heavy menstrual bleeding.
abstract: OBJECTIVE
  To quantify the change in work productivity and activities of daily living in North American women with heavy menstrual bleeding (HMB) treated with estradiol valerate/dienogest (E2V/DNG; Qlaira(®)/Natazia(®)) compared to placebo.
  
  
  METHODS
  Women in the United States and Canada, aged 20-53 years with an objective diagnosis of HMB and no recognizable anatomical pathology, were treated with E2V/DNG or placebo for seven cycles (196 days). Main outcome measures included work productivity (i.e., productivity while at work) and activities of daily living measured using a modified Work Productivity and Activity Impairment Questionnaire (mWPAI) on a Likert scale from 0 to 10 (higher values denote higher impairment levels).
  
  
  RESULTS
  In both countries, significant improvement was observed between baseline and end of treatment in work productivity and activities of daily living impairment. The improvements in work productivity and activities of daily living with E2V/DNG treatment relative to placebo ranged from 37.2% to 39.2% across both countries. Monthly gains due to E2V/DNG treatment (net of placebo improvement) associated with improvement in work productivity were estimated to be US$80.2 and Can$70.8 (US$58.5) and those associated with improvement in activities of daily living were estimated to be US$84.9 and Can$73.5 (US$60.7).
  
  
  CONCLUSIONS
  E2V/DNG was shown to have a consistent positive impact on work productivity and activities of daily living in U.S. and Canadian women with HMB. In addition, these improvements in work productivity and activities of daily living were associated with a reduction in HMB-related monetary burden compared to the placebo group.
authors.affiliation: United BioSource Corporation, London, United Kingdom.
authors.forename: Radoslaw
authors.initials: R
authors.lastname: Wasiak
authors.forename: Anna
authors.initials: A
authors.lastname: Filonenko
authors.forename: David J
authors.initials: DJ
authors.lastname: Vanness
authors.forename: Amy
authors.initials: A
authors.lastname: Law
authors.forename: Mark
authors.initials: M
authors.lastname: Jeddi
authors.forename: Kim U
authors.initials: KU
authors.lastname: Wittrup-Jensen
authors.forename: Donald E
authors.initials: DE
authors.lastname: Stull
authors.forename: Steven
authors.initials: S
authors.lastname: Siak
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Jensen
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D003278:Contraceptives, Oral, Hormonal / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D004526:Efficiency; D004958:Estradiol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008595:Menorrhagia / Q000188:drug therapy*; D008875:Middle Aged; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome; D014937:Work; D055815:Young Adult
chemical_list: D003278:Contraceptives, Oral, Hormonal; D004338:Drug Combinations; C454300:estradiol valerate-dienogest; D004958:Estradiol; D009277:Nandrolone