title: Cell cycle control across the eukaryotic kingdom.
abstract: Almost two billion years of evolution have generated a vast and amazing variety of eukaryotic life with approximately 8.7 million extant species. Growth and reproduction of all of these organisms depend on faithful duplication and distribution of their chromosomes to the newly forming daughter cells in a process called the cell cycle. However, most of what is known today about cell cycle control comes from a few model species that belong to the unikonts; that is, to only one of five 'supergroups' that comprise the eukaryotic kingdom. Recently, analyzing species from distantly related clades is providing insights into general principles of cell cycle regulation and shedding light on its evolution. Here, referring to animal and fungal as opposed to non-unikont systems, especially flowering plants from the archaeplastid supergroup, we compare the conservation of central cell cycle regulator functions, the structure of network topologies, and the evolutionary dynamics of substrates of core cell cycle kinases.
authors.affiliation: Department of Molecular Mechanisms of Phenotypic Plasticity, Institut de Biologie Moléculaire des Plantes du Centre National de la Recherche Scientifique, Université de Strasbourg, F-67084 Strasbourg, France.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Harashima
authors.forename: Nico
authors.initials: N
authors.lastname: Dissmeyer
authors.forename: Arp
authors.initials: A
authors.lastname: Schnittger
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D059447:Cell Cycle Checkpoints / Q000235:genetics / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000145:classification / Q000235:genetics / Q000378:metabolism; D016213:Cyclins / Q000145:classification / Q000235:genetics / Q000378:metabolism; D005057:Eukaryotic Cells / Q000145:classification / Q000378:metabolism / Q000502:physiology*; D053263:Gene Regulatory Networks; D006801:Humans; D010802:Phylogeny
chemical_list: D016213:Cyclins; D018844:Cyclin-Dependent Kinases