title: Quantitative assessment of myofibroblast in severe dysplasia, microinvasion and oral squamous cell carcinoma: an immunohistochemical study.
abstract: Myofibroblast are essential for the integrity of human body by virtue of its role in wound healing and pathological organ remodeling. Myofibroblast is a universal cellular component in mammalian lesions, but not a typical component of normal untraumatized tissues. Therefore its presence in abundance in case of cancer is a matter of concern. Tumor microenvironment plays a pivotal role in tumor progression. These so called cancer associated fibroblast or myofibroblast are the major components and occur in stromal tissue during carcinogenesis processes. This study is a quantitative assessment of presence and distribution of myofibroblast in severe dysplasia, microinvasion and oral squamous cell carcinoma (OSCC).
  
  
  BACKGROUND
  Myofibroblast, Vimentin, α-SMA, OSCC, Severe dysplasia, Microinvasion. How to cite this article: Kapse SC, Rathod N, Baad R, Mandlik J, Sharma AS, Bommanavar S. Quantitative Assessment of Myofibroblast in Severe Dysplasia, Microinvasion and Oral Squamous Cell Carcinoma: An Immunohistochemical Study. J Contemp Dent Pract 2013;14(1):34-38. Source of support: Nil Conflict of interest: None declared.
authors.affiliation: Department of Oral Pathology, MA, Rangoonwala Dental College, Pune, Maharashtra, India. drsonamm@yahoo.co.in
authors.forename: Sonam C
authors.initials: SC
authors.lastname: Kapse
authors.forename: Nanita
authors.initials: N
authors.lastname: Rathod
authors.forename: Rajendra
authors.initials: R
authors.lastname: Baad
authors.forename: Jyoti
authors.initials: J
authors.lastname: Mandlik
authors.forename: Anupam S
authors.initials: AS
authors.lastname: Sharma
authors.forename: Sushma
authors.initials: S
authors.lastname: Bommanavar
mesh_terms: D000199:Actins / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002452:Cell Count; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D009062:Mouth Neoplasms / Q000473:pathology*; D058628:Myofibroblasts / Q000473:pathology* / Q000502:physiology; D009361:Neoplasm Invasiveness; D011230:Precancerous Conditions / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology; D059016:Tumor Microenvironment / Q000502:physiology; D014746:Vimentin / Q000032:analysis
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D014746:Vimentin