title: STILLE CROSS-COUPLING REACTIONS OF ARYL MESYLATES AND TOSYLATES USING A BIARYLPHOSPHINE BASED CATALYST SYSTEM.
abstract: A catalyst system for the Stille cross-coupling reactions of aryl mesylates and tosylates is reported. Using the combination of Pd(OAc)2, XPhos, and CsF int-BuOH an array of aryl and heteroaryl sulfonates were successfully employed in these reactions. Morever, heteroarylstannanes, such as furyl, thiophenyl, andN-methylpyrrole, which are often prone to decomposition, were efficiently coupled under these conditions.Ortho-substitution on the stannane coupling partner was well tolerated; however, the presence oforthosubstituents on the aryl sulfonates greatly reduced the proficiency of these reactions.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Naber
authors.forename: Brett P
authors.initials: BP
authors.lastname: Fors
authors.forename: Xiaoxing
authors.initials: X
authors.lastname: Wu
authors.forename: Jonathon
authors.initials: J
authors.lastname: Gunn
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald