title: Bidirectional promoters in the transcription of mammalian genomes.
abstract: In the genomes of humans and other mammals a large number of closely spaced pairs of genes that are transcribed in opposite directions were revealed. Their transcription is directed by so-called bidirectional promoters. This review is devoted to the characteristics of bidirectional promoters and features of their structure. The composition of "core" promoter elements in conventional unidirectional and bidirectional promoters is compared. Data on binding sites of transcription factors that are primarily specific for bidirectional promoters are discussed. The examples of promoters that share protein-coding genes transcribed by RNA polymerase II and the non-coding RNA genes transcribed by RNA polymerase III are described. Data obtained from global transcriptome analysis about the existence of short noncoding antisense RNA associated with the promoters in the context of the hypothesis of bidirectional transcription initiation as an inherent property of eukaryotic promoters are discussed.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia. rubtsov@eimb.ru
authors.forename: A S
authors.initials: AS
authors.lastname: Orekhova
authors.forename: P M
authors.initials: PM
authors.lastname: Rubtsov
mesh_terms: D000818:Animals; D016678:Genome / Q000235:genetics*; D006801:Humans; D008322:Mammals / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012319:RNA Polymerase II / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D012319:RNA Polymerase II