title: Rapidly evolving hypopituitarism in a boy with multiple autoimmune disorders.
abstract: A 10-year-old boy with acute onset cranial diabetes insipidus and multiple autoimmune disorders had evolving panhypopituitarism, thought to be due to autoimmune hypophysitis. Over 18 months, a dramatic clinical course with progressive hypopituitarism and development of type 1 diabetes mellitus was evident. Serial brain imaging showed changes suggestive of germinoma.
authors.affiliation: Department of Endocrinology and Diabetes, The Royal Children's Hospital, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
authors.forename: Ganesh
authors.initials: G
authors.lastname: Jevalikar
authors.forename: Sze Choong
authors.initials: SC
authors.lastname: Wong
authors.forename: Margaret
authors.initials: M
authors.lastname: Zacharin
mesh_terms: D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis*; D002648:Child; D020790:Diabetes Insipidus, Neurogenic / Q000175:diagnosis / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000209:etiology*; D018237:Germinoma / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007018:Hypopituitarism / Q000175:diagnosis / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010870:Pineal Gland
keywords: autoimmune; germinoma; hypopituitarism