title: Ferracyclic carbamoyl complexes related to the active site of [Fe]-hydrogenase.
abstract: The active site of the [Fe]-hydrogenase features an iron(II) centre bearing cis carbonyl groups and a chelating pyridine-acyl ligand. Reproducing these unusual features in synthetic models is an intriguing challenge, which will allow both better understanding of the enzymatic system and more fundamental insight into the coordination modes of iron. By using the carbamoyl group as a surrogate for acyl, we have been able to synthesize a range of ferracyclic complexes. Initial reaction of Fe(CO)4Br2 with 2-aminopyridine yields a complex bearing a labile solvent molecule, which can be replaced by stronger donors bearing phosphorus atoms to produce a number of derivatives. Introduction of a hydroxy group using this method is unsuccessful both with a free OH group and when this is silyl-protected. In contrast, the analogous reactions starting from 2,6-diaminopyridine does allow synthesis of complexes bearing a pendant basic group.
authors.affiliation: Energy Materials Laboratory, School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Turrell
authors.forename: Amanda D
authors.initials: AD
authors.lastname: Hill
authors.forename: Saad K
authors.initials: SK
authors.lastname: Ibrahim
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Wright
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Pickett
mesh_terms: D000215:Acylation; D000631:Aminopyridines / Q000138:chemical synthesis / Q000737:chemistry*; D032701:Biomimetics; D020134:Catalytic Domain; D005296:Ferrous Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D006864:Hydrogenase / Q000737:chemistry*; D007506:Iron-Sulfur Proteins / Q000737:chemistry*; D008958:Models, Molecular; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000631:Aminopyridines; D005296:Ferrous Compounds; D007506:Iron-Sulfur Proteins; D011725:Pyridines; C118830:iron hydrogenase; D006864:Hydrogenase; C505797:2,6-diaminopyridine; C032439:alpha-aminopyridine