title: Rubella epidemic caused by genotype 1E rubella viruses in Beijing, China, in 2007-2011.
abstract: BACKGROUND
  A series of different rubella vaccination strategies were implemented to control rubella and prevent congenital rubella virus infection in Beijing, China. The rubella vaccine was available in 1995 in Beijing, and was introduced into the Beijing immunization program (vaccine recipients at their own expense vaccination) in 2000, and was introduced into the National Expanded Program on Immunization (vaccine recipients free vaccination) in 2006. Rubella virological surveillance started in Beijing in 2007.
  
  
  RESULTS
  The reported rubella incidence rate has decreased dramatically due to the introduction of the vaccine in Beijing since 1995. However, rubella epidemics occurred regardless in 2001 and 2007. The incidence rate among the floating population has gradually increased since 2002, reaching 2 or more times that in the permanent resident population. The peak age of rubella cases gradually changed from <15 years of age to adults after 2005. Phylogenetic analysis was performed and a phylogenetic tree was constructed based on the World Health Organization standard sequence window for rubella virus isolates. All Beijing rubella virus isolates belong to genotype 1E/cluster1 and were clustered interspersed with viruses from other provinces in China. The effective number of infections indicated by a Bayesian skyline plot remained constant from 2007 to 2011.
  
  
  CONCLUSIONS
  The proportion of rubella cases among the floating population has increased significantly in Beijing since 2002, and the disease burden gradually shifted to the older age group (15- to 39-year olds), which has become a major group with rubella infection since 2006. Genotype 1E rubella virus continuously caused a rubella epidemic in Beijing in 2007-2011 and was the predominant virus, and all Beijing genotype 1E viruses belong to cluster 1, which is also widely circulated throughout the country.
authors.affiliation: Beijing Center for Diseases Prevention and Control, No. 16, Hepingli Middle Street, Dongcheng District, Beijing 100013, People's Republic of China.
authors.forename: Meng
authors.initials: M
authors.lastname: Chen
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhu
authors.forename: Donglei
authors.initials: D
authors.lastname: Liu
authors.forename: Guohong
authors.initials: G
authors.lastname: Huang
authors.forename: Fang
authors.initials: F
authors.lastname: Huang
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
authors.forename: Tiegang
authors.initials: T
authors.lastname: Zhang
authors.forename: Wenbo
authors.initials: W
authors.lastname: Xu
authors.forename: Xinghuo
authors.initials: X
authors.lastname: Pang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D058872:Epidemics; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D012409:Rubella / Q000453:epidemiology*; D012411:Rubella Vaccine / Q000008:administration & dosage; D012412:Rubella virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D014611:Vaccination / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D012367:RNA, Viral; D012411:Rubella Vaccine