title: Levels of PEDF in pleural effusions from lung adenocarcinoma and benign disease patients.
abstract: Anti-tumor properties assigned to PEDF, beside its role as an inhibitor of angiogenesis, make it a promising candidate in the search of new biomarkers for malignancy. In this study levels of PEDF were investigated in pleural effusions from lung adenocarcinoma and benign inflammatory disease patients. The mean PEDF concentration in the malignant group was slightly superior to that in patients suffering benign diseases (4.59 μ g/mL vs 3.97 μg/mL), although the difference did not reach statistical significance (P 0.166). Pleural effusion PEDF levels were not related to gender, age, smoking habit or pleural effusion size. We also investigated the possible relationship of PEDF levels in pleural effusion regarding clinicopathological features. Correlations were found for monocytes (P 0.010) and polymorphonuclear leukocytes (P 0.023) with PEDF levels in pleural effusion of malignant origin.
authors.affiliation: Department of Biochemistry, Genetic and Immunology, Facultad de Biología, Universidad de Vigo, Vigo, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Sánchez-Otero
authors.forename: Sonia
authors.initials: S
authors.lastname: Blanco-Prieto
authors.forename: Lorena
authors.initials: L
authors.lastname: Vázquez-Iglesias
authors.forename: María
authors.initials: M
authors.lastname: Páez de la Cadena
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernández-Villar
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Botana-Rial
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Rodríguez-Berrocal
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000453:epidemiology; D000367:Age Factors; D014408:Biomarkers, Tumor / Q000032:analysis*; D016022:Case-Control Studies; D005136:Eye Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000032:analysis*; D016066:Pleural Effusion, Malignant / Q000737:chemistry*; D015843:Serpins / Q000032:analysis*; D012737:Sex Factors; D012907:Smoking; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D014408:Biomarkers, Tumor; D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor