title: The rice MAPKK-MAPK interactome: the biological significance of MAPK components in hormone signal transduction.
abstract: Mitogen-activated protein kinase (MAPK) signaling cascades are evolutionarily conserved fundamental signal transduction pathways. A MAPK cascade consists of many distinct MAPKKK-MAPKK-MAPK modules linked to various upstream receptors and downstream targets through sequential phosphorylation and activation of the cascade components. These cascades collaborate in transmitting a variety of extracellular signals and in controlling cellular responses and processes such as growth, differentiation, cell death, hormonal signaling, and stress responses. Although MAPK proteins play central roles in signal transduction pathways, our knowledge of MAPK signaling in hormonal responses in rice has been limited to a small subset of specific upstream and downstream interacting targets. However, recent studies revealing direct MAPK and MAPKK interactions have provided the basis for elucidating interaction specificities, functional divergence, and functional modulation during hormonal responses. In this review, we highlight current insights into MAPKK-MAPK interaction patterns in rice, with emphasis on the biological significance of these interacting pairs in SA (salicylic acid), JA (jasmonic acid), ET (ethylene), and ABA (abscisic acid) responses, and discuss the challenges in understanding functional signal transduction networks mediated by these hormones.
authors.affiliation: Department of Molecular Biology, College of Life Sciences, Sejong University, Gunja-dong, Gwangjin-gu, Seoul 143-747, Republic of Korea.
authors.forename: Raksha
authors.initials: R
authors.lastname: Singh
authors.forename: Nam-Soo
authors.initials: NS
authors.lastname: Jwa
mesh_terms: D000040:Abscisic Acid / Q000378:metabolism; D005030:Ethylenes / Q000378:metabolism; D020930:MAP Kinase Kinase Kinases / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D012275:Oryza / Q000378:metabolism* / Q000502:physiology; D010937:Plant Growth Regulators / Q000378:metabolism*; D010940:Plant Proteins / Q000378:metabolism; D060066:Protein Interaction Maps; D020156:Salicylic Acid / Q000378:metabolism
chemical_list: D005030:Ethylenes; D010937:Plant Growth Regulators; D010940:Plant Proteins; D000040:Abscisic Acid; C036216:ethylene; D020928:Mitogen-Activated Protein Kinases; D020930:MAP Kinase Kinase Kinases; D020156:Salicylic Acid