title: Antidiabetic and hypolipidemic activities of Kigelia pinnata flowers extract in streptozotocin induced diabetic rats.
abstract: OBJECTIVE
  To evaluate antidiabetic and hypolipidemic activities of Kigelia pinnata methanolic flowers extract in streptozotocin (STZ) induced diabetic wistar rat.
  
  
  METHODS
  Rats were made diabetic by a single dose of STZ at 60 mg/kg body weight i.p. The blood glucose level was checked before and 72 h after STZ injection to confirm the development of diabetes. The flower extract and glibenclamide were administered orally at the doses of 250 and 500 mg/kg body weight for 21 days.
  
  
  RESULTS
  Daily oral treatment with the extract and standard drug for 21 days significantly reduced blood glucose, serum cholesterol and triglycerides levels. High density lipoprotein-cholesterol level was found to be improved (P<0.01) as compared to diabetic control group.
  
  
  CONCLUSIONS
  It is concluded that Kigellia pinnata flowers extract have significant antidiabetic and hypolipidemic effect.
authors.affiliation: Institute of Pharmaceutical Sciences, Kurukshetra University, Haryana, India.
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.forename: V
authors.initials: V
authors.lastname: Kumar
authors.forename: O M
authors.initials: OM
authors.lastname: Prakash
mesh_terms: D000284:Administration, Oral; D000818:Animals; D029402:Bignoniaceae / Q000737:chemistry*; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004195:Disease Models, Animal; D005260:Female; D035264:Flowers / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000302:isolation & purification; D000960:Hypolipidemic Agents / Q000008:administration & dosage* / Q000302:isolation & purification; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage* / Q000302:isolation & purification; D017208:Rats, Wistar; D013311:Streptozocin / Q000008:administration & dosage / Q000633:toxicity; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008075:Lipoproteins, HDL; D010936:Plant Extracts; D014280:Triglycerides; D013311:Streptozocin; D002784:Cholesterol
keywords: Antidiabetic; Kigelia pinnata; Streptozotocin