title: [Multiple familial trichoepithelioma: a new CYLD gene mutation].
abstract: BACKGROUND
  Multiple familial trichoepithelioma (MFT) is an autosomal dominant disease characterized by the development of numerous skin-coloured papules on the central area of the face. It is associated with various CYLD gene mutations that are also responsible for familial cylindromatosis and Brooke-Spiegler syndrome.
  
  
  METHODS
  We report a novel mutation in the CYLD gene in a family with MFT and discuss new developments in therapeutic options.
  
  
  CONCLUSIONS
  Recent studies indicate that CYLD is a tumour-suppressor gene.
authors.affiliation: Service de dermatologie, université catholique de Lille, hôpital Saint-Vincent de Paul, 51, boulevard de Belfort, BP 387, 59020 Lille cedex, France. adeline.duparc@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Duparc
authors.forename: A
authors.initials: A
authors.lastname: Lasek-Duriez
authors.forename: T
authors.initials: T
authors.lastname: Wiart
authors.forename: B
authors.initials: B
authors.lastname: Duban-Bedu
authors.forename: P
authors.initials: P
authors.lastname: Gosset
authors.forename: P
authors.initials: P
authors.lastname: Modiano
mesh_terms: D000293:Adolescent; D000328:Adult; D017679:Cryotherapy; D000074749:Deubiquitinating Enzyme CYLD; D005602:France; D006579:Heterozygote; D006801:Humans; D053685:Laser Therapy; D054020:Lasers, Gas; D008297:Male; D009154:Mutation; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics* / Q000628:therapy; D017422:Sequence Analysis, DNA; D012878:Skin Neoplasms; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D025521:Tumor Suppressor Proteins; C409984:CYLD protein, human; D000074749:Deubiquitinating Enzyme CYLD