title: Inhibition of Ehrlich ascites carcinoma by Manilkara zapota L. stem bark in Swiss albino mice.
abstract: OBJECTIVE
  To evaluate the antitumor activity of Manilkara zapota (M. zapota) L. stem bark against Ehrlich ascites carcinoma (EAC) in Swiss albino mice.
  
  
  METHODS
  The in vivo antitumour activity of the ethyl acetate extract of stem bark of M. zapota L. (EASM) was evaluated at 50, 100 and 200 mg/kg bw against EAC using mean survival time. After administration of the extract of M. zapota, viable EAC cell count and body weight in the EAC tumour hosts were observed. The animal was also observed for improvement in the haematological parameters (e.g., heamoglobin content, red and white blood cells count and differential cell count) after EASM treatment.
  
  
  RESULTS
  Intraperitoneal administration of EASM reduced viable EAC cells, increased the survival time, and restored altered haematological parameters. Significant efficacy was observed for EASM at 100 mg/kg dose (P<0.05).
  
  
  CONCLUSIONS
  It can be concluded that the ethyl acetate extract of stem bark of M. zapota L. possesses significant antitumour activity.
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Science, Rajshahi University, Rajshahi-6205, Bangladesh.
authors.forename: M Abu
authors.initials: MA
authors.lastname: Osman
authors.forename: M Mamunur
authors.initials: MM
authors.lastname: Rashid
authors.forename: M Abdul
authors.initials: MA
authors.lastname: Aziz
authors.forename: M Rowshahul
authors.initials: MR
authors.lastname: Habib
authors.forename: M Rezaul
authors.initials: MR
authors.lastname: Karim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D001835:Body Weight; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D008297:Male; D032129:Manilkara / Q000737:chemistry*; D051379:Mice; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts
keywords: Antitumour activity; Ehrlich ascites carcinoma; Haematological parameter; Manilkara zapota; Stem bark