title: Selective intermittent preventive treatment of vivax malaria: reduction of malaria incidence in an open cohort study in brazilian Amazon.
abstract: In children, the Intermittent Preventive Treatment (IPTc), currently called Seasonal Malaria Chemoprevention (SMC), was considered effective on malaria control due to the reduction of its incidence in Papua New Guinea and in some areas with seasonal malaria in Africa. However, the IPT has not been indicated because of its association with drug resistance and for hindering natural immunity development. Thus, we evaluated the alternative IPT impact on malaria incidence in three riverside communities on Madeira River, in the municipality of Porto Velho, RO. We denominate this scheme Selective Intermittent Preventive Treatment (SIPT). The SIPT consists in a weekly dose of two 150 mg chloroquine tablets for 12 weeks, for adults, and an equivalent dose for children, after complete supervised treatment for P. vivax infection. This scheme is recommend by Brazilian Health Ministry to avoid frequent relapses. The clinic parasitological and epidemiological surveillance showed a significant reduction on vivax malaria incidence. The results showed a reduction on relapses and recurrence of malaria after SIPT implementation. The SIPT can be effective on vivax malaria control in localities with high transmission risk in the Brazilian Amazon.
authors.affiliation: Instituto de Pesquisas em Patologias Tropicais (IPEPATRO), Rua da Beira, 7671, Bairro Lagoa, 76.812-245 Porto Velho, RO, Brazil ; Fundação Oswaldo Cruz (FIOCRUZ Rondônia), Rua da Beira, 7671, Bairro Lagoa, 76.812-245 Porto Velho, RO, Brazil.
authors.forename: Tony Hiroshi
authors.initials: TH
authors.lastname: Katsuragawa
authors.forename: Luiz Herman Soares
authors.initials: LH
authors.lastname: Gil
authors.forename: Alzemar Alves
authors.initials: AA
authors.lastname: de Lima
authors.forename: Elci Marlei
authors.initials: EM
authors.lastname: Freitag
authors.forename: Tatiana Marcondes
authors.initials: TM
authors.lastname: Dos Santos
authors.forename: Maria Teixeira
authors.initials: MT
authors.lastname: do Nascimento Filha
authors.forename: Alcides Procópio Justiniano
authors.initials: AP
authors.lastname: Dos Santos Júnior
authors.forename: Josiane Mendes
authors.initials: JM
authors.lastname: da Silva
authors.forename: Aline de Freitas
authors.initials: Ade F
authors.lastname: Rodrigues
authors.forename: Mauro Shugiro
authors.initials: MS
authors.lastname: Tada
authors.forename: Cor Jesus Fernandes
authors.initials: CJ
authors.lastname: Fontes
authors.forename: Luiz Hildebrando
authors.initials: LH
authors.lastname: Pereira da Silva