title: [Clinical research of early intervention of modified shuyu pill in vascular cognitive impairment no dementia].
abstract: OBJECTIVE
  To observe early intervention effects of Modified Shuyu Pill (MSP) on vascular cognitive impairment no dementia (VCIND).
  
  
  METHODS
  Totally 100 patients VCIND were randomly assigned to the treatment group (43 cases) and the control group (33 cases). On the basis of the treatment targeting risk factors of blood vessels, patients in the treatment group were treated by MSP, while those in the control group were treated by donepezil hydrochloride. The therapeutic course was 16 weeks. The neuropsychological scales [mini-mental state examination (MMSE) and Montreal cognitive assessment (MOCA) score] and Chinese medicine dementia syndromes scales were observed before and after treatment.
  
  
  RESULTS
  The MMSE and MOCA score of the two groups increased when compared with the same group before treatment (P < 0.01). But there was no statistical difference in MMSE or MOCA score after treatment between the two groups (P > 0.05). The Chinese medicine dementia syndromes scales significantly decreased in the treatment group when compared with before treatment (P < 0.01). But there was no statistical difference in Chinese medicine dementia syndromes scales in the control group between before and after treatment (P > 0.05). There was statistical difference in Chinese medicine dementia syndromes scales after treatment between the two groups (P < 0.01).
  
  
  CONCLUSIONS
  MSP could effectively intervene the progress of VCIND.
authors.affiliation: Gerontology Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430000, China. tanzihu2008@163.com
authors.forename: Zi-Hu
authors.initials: ZH
authors.lastname: Tan
authors.forename: Han-Chao
authors.initials: HC
authors.lastname: Lan
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Shan-Ping
authors.initials: SP
authors.lastname: Mao
authors.forename: Yun-Fei
authors.initials: YF
authors.lastname: Zha
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Xiao
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000517:prevention & control*; D000077265:Donepezil; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D061345:Early Medical Intervention; D005260:Female; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use
chemical_list: D004365:Drugs, Chinese Herbal; D007189:Indans; D010880:Piperidines; D000077265:Donepezil