title: Impact of interpretative commenting on lipid profiles in people at high risk of familial hypercholesterolaemia.
abstract: BACKGROUND
  Familial hypercholesterolaemia (FH) is an autosomal dominant condition characterised by increased low density lipoprotein cholesterol (LDL-c), xanthomata and premature cardiovascular disease. However, it is currently underdiagnosed and undertreated in Australasia. We sought to investigate whether interpretative commenting on lipid profiles could improve FH detection and treatment.
  
  
  METHODS
  A case-historical control study of individuals with serum LDL-c concentrations ≥6.5 mmol/L; 96 cases receiving an interpretative comment suggesting FH compared with 100 controls not receiving a comment.
  
  
  RESULTS
  Serum LDL-c was repeated in 63 (66%) cases and 70 (70%) controls within 12 months. LDL-c decreased in 59 (94%) cases and in 61 (87%) controls. In individuals with a repeat LDL-c, a mean LDL-c reduction of 2.3 mmol/L (32%; p<0.0001) was demonstrated in controls, compared with 3.0 mmol/L (42%; p<0.0001) in cases; significantly greater than that of controls (p<0.005). Interpretative comments suggesting specialist review were associated with a higher referral rate compared with controls (11.5% vs 1%, p<0.05).
  
  
  CONCLUSIONS
  Interpretative commenting was associated with a significant additional LDL-c reduction and increased specialist referrals compared with controls. However, only a minority of individuals received a specialist referral. Interpretative commenting may play an important role in the detection and management of FH.
authors.affiliation: Department of Clinical Biochemistry, Royal Perth Hospital, Perth, WA, Australia. damon.bell1@yahoo.com
authors.forename: Damon A
authors.initials: DA
authors.lastname: Bell
authors.forename: Robert
authors.initials: R
authors.lastname: Bender
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Hooper
authors.forename: Jenny
authors.initials: J
authors.lastname: McMahon
authors.forename: Glenn
authors.initials: G
authors.lastname: Edwards
authors.forename: Frank M
authors.initials: FM
authors.lastname: van Bockxmeer
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Watts
authors.forename: John R
authors.initials: JR
authors.lastname: Burnett
mesh_terms: D044362:Australasia; D008078:Cholesterol, LDL / Q000097:blood* / Q000592:standards; D019963:Clinical Chemistry Tests / Q000379:methods*; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D008078:Cholesterol, LDL