title: Clinical profile of generalized vitiligo patients with associated autoimmune/autoinflammatory diseases.
abstract: BACKGROUND
  The significance of associated autoimmune/autoinflammatory diseases in generalized vitiligo patients with respect to their clinical profile has not yet been completely established.
  
  
  OBJECTIVE
  The objective of this study was to evaluate the clinical significance of associated autoimmune/autoinflammatory diseases in generalized vitiligo patients with respect to some general clinical variables, distribution pattern, disease activity and treatment response.
  
  
  METHODS
  Seven hundred generalized vitiligo patients were included in this retrospective observational cohort study.
  
  
  RESULTS
  Associated autoimmune/autoinflammatory diseases were present in 15.4% of the patient population and were more common in women compared with men, especially concerning thyroid disease. Only vitiligo patients with thyroid disease had clear different clinical characteristics. The percentage of total body surface area involvement was significantly (P = 0.005) higher in the presence of thyroid disease which was more pronounced in women compared with men. Patients with thyroid disease had a particular predisposition to acral and joint depigmentations. No clear differences in disease activity or response to therapy were observed in vitiligo patients with or without autoimmune/autoinflammatory disorders.
  
  
  CONCLUSIONS
  The presence of associated autoimmune/autoinflammatory diseases seems to influence the clinical profile of generalized vitiligo patients. Our results support the hypothesis that in the presence of a thyroid disorder, the disease activity of vitiligo is more extensive, in particular on areas prone to friction.
authors.affiliation: Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
authors.forename: N
authors.initials: N
authors.lastname: van Geel
authors.forename: M
authors.initials: M
authors.lastname: Speeckaert
authors.forename: L
authors.initials: L
authors.lastname: Brochez
authors.forename: J
authors.initials: J
authors.lastname: Lambert
authors.forename: R
authors.initials: R
authors.lastname: Speeckaert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000150:complications; D014820:Vitiligo / Q000175:diagnosis* / Q000276:immunology* / Q000628:therapy; D055815:Young Adult