title: Co-enzyme Q10 to treat neurological disorders: basic mechanisms, clinical outcomes, and future research direction.
abstract: Coenzyme Q10 (CoQ10) is critical for the cell power supply in mitochondria. CoQ10 shuttles electrons from complexes I and II to complex III, and can be anti-oxdiative. Neurons require high energy for synaptic transmission and therefore the mitochondria dysfunction often leads to severe neuronal degeneration, as observed in many neurological disorders. CoQ10 supplementation has been widely used to treat aging, stroke, neuromuscular diseases, Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy, autosomal recessive cerebellar ataxias, Huntington's disease and amyotrophic lateral sclerosis. Here we discuss a large number of preclinical and clinical trials for CoQ10 to elucidate the mechanisms underlying CoQ10 therapy. The rational applications as a therapeutic agent in neurological disorders are discussed.
authors.affiliation: Toxicology Department and Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Mansoura, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Salama
authors.forename: Ti-Fei
authors.initials: TF
authors.lastname: Yuan
authors.forename: Sergio
authors.initials: S
authors.lastname: Machado
authors.forename: Eric
authors.initials: E
authors.lastname: Murillo-Rodríguez
authors.forename: José A
authors.initials: JA
authors.lastname: Vega
authors.forename: Manuel
authors.initials: M
authors.lastname: Menéndez-González
authors.forename: Antonio E
authors.initials: AE
authors.lastname: Nardi
authors.forename: Oscar
authors.initials: O
authors.lastname: Arias-Carrión
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends*; D045222:Electron Transport Chain Complex Proteins / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000187:drug effects; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D045222:Electron Transport Chain Complex Proteins; D018696:Neuroprotective Agents; D014451:Ubiquinone; C024989:coenzyme Q10