title: A mild and efficient flow procedure for the transfer hydrogenation of ketones and aldehydes using hydrous zirconia.
abstract: A flow chemistry Meerwein-Ponndorf-Verley (MPV) reduction procedure using partially hydrated zirconium oxide via a machine-assisted approach is reported. The heterogeneous reductive system could be applied to a wide range of functionalized substrates, allowing clean and fast delivery of the alcohol products within a few minutes (6-75 min). In three examples the system was scaled to deliver 50 mmol of product.
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.
authors.forename: Claudio
authors.initials: C
authors.lastname: Battilocchio
authors.forename: Joel M
authors.initials: JM
authors.lastname: Hawkins
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D007659:Ketones / Q000737:chemistry*; D013237:Stereoisomerism; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000447:Aldehydes; D007659:Ketones; D015040:Zirconium; C028541:zirconium oxide