title: Interleukin-6, interleukin-1 beta and interleukin-1 receptor antagonist levels in epileptic seizures.
abstract: OBJECTIVE
  Data are accumulating to support the involvement of inflammatory mechanisms in the pathogenesis and course of epilepsy.
  
  
  METHODS
  The aim of this study was to examine seizure-induced changes in plasma concentrations of interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1Ra), and interleukin-1 beta (IL-1β) in 23 patients with epilepsy undergoing a video-electroencephalography (EEG) study. Patients were divided into groups based on epilepsy type as follows: temporal lobe epilepsy (TLE) (n=6), extra-temporal lobe epilepsy (XLE) (n=8) and idiopathic generalised epilepsy (IGE) (n=9). Serum levels of IL-1β, IL-1Ra and IL-6 were measured at baseline, immediately after the epileptic seizure, and at 3h, 6h, 12h and 24h after the seizure.
  
  
  RESULTS
  We demonstrated a significant increase in plasma levels of IL-6 and IL-1Ra that peaked at 12h into the post-ictal period (p<0.05). IL-1β levels did not differ from the baseline levels. We did not observe any differences in post-ictal cytokine release patterns between the TLE, XLE and IGE groups.
  
  
  CONCLUSIONS
  The present study confirms the findings that epileptic seizures induce the production of IL-6 and IL-1Ra.
authors.affiliation: Izmir Tepecik Educational and Research Hospital, Neurology Clinic, Turkey. fatmairem@yahoo.com
authors.forename: Irem Fatma
authors.initials: IF
authors.lastname: Uludag
authors.forename: Sule
authors.initials: S
authors.lastname: Bilgin
authors.forename: Yasar
authors.initials: Y
authors.lastname: Zorlu
authors.forename: Gamze
authors.initials: G
authors.lastname: Tuna
authors.forename: Guldal
authors.initials: G
authors.lastname: Kirkali
mesh_terms: D000293:Adolescent; D000328:Adult; D004569:Electroencephalography; D004827:Epilepsy / Q000097:blood* / Q000145:classification; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood*; D053583:Interleukin-1beta / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014741:Video Recording; D055815:Young Adult
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta; D015850:Interleukin-6