title: Cyclodextrin-derived pH-responsive nanoparticles for delivery of paclitaxel.
abstract: Engineering of pH-responsive nanoplatforms can be facilely achieved from acetalated α-cyclodextrin materials. The hydrolysis period of nanoparticles can be precisely tailored by using materials with various acetal types that can be easily controlled by acetalation time. These nanomaterials with pH-modulated hydrolysis and pH-triggered drug delivery capability show good biocompatibility in vitro and in vivo. Incorporation of anticancer drug paclitaxel (PTX) into newly developed pH-sensitive nanosystems leads to nanotherapeutics with significantly improved cytotoxic activity against various tumor cells. Importantly, thus formulated nanomedicines can reverse the multidrug resistance of PTX-resistant cancer cells. In vivo antitumor studies also reveal the superior of pH-sensitive nanosystems over pristine PTX and pH-insensitive PLGA nanoformulations. Moreover, comparison with other two acid-labile materials evidenced the advantages of cyclodextrin-based nanovehicles with respect to drug loading capacity, in vitro and in vivo activity as well as alleviated adverse effects. These pH-responsive nanoparticles may serve as new generation nanocarriers for drug delivery.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: He
authors.forename: Sha
authors.initials: S
authors.lastname: Chen
authors.forename: Jianzhi
authors.initials: J
authors.lastname: Zhou
authors.forename: Yin
authors.initials: Y
authors.lastname: Dou
authors.forename: Liu
authors.initials: L
authors.lastname: Song
authors.forename: Ling
authors.initials: L
authors.lastname: Che
authors.forename: Xing
authors.initials: X
authors.lastname: Zhou
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Jia
authors.forename: Jianxiang
authors.initials: J
authors.lastname: Zhang
authors.forename: Shuhui
authors.initials: S
authors.lastname: Li
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Li
mesh_terms: D000107:Acetylation / Q000187:drug effects; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D017239:Paclitaxel / Q000494:pharmacology*; D023382:Toxicity Tests, Acute; D023041:Xenograft Model Antitumor Assays; D047391:alpha-Cyclodextrins / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D047391:alpha-Cyclodextrins; D017239:Paclitaxel; C032613:alpha-cyclodextrin