title: Metal-catalyzed cascade rearrangements of 3-alkynyl flavone ethers.
abstract: Metal-mediated rearrangements of 3-alkynyl flavone ethers are reported. The overall process involves 5-endo enyne cyclization to a platinum-containing spiro-oxocarbenium intermediate which may be trapped with methanol to produce spirodihydrofurans or further rearranged to afford either allenyl chromanediones or benzofuranones.
authors.affiliation: Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xiong
authors.forename: Scott E
authors.initials: SE
authors.lastname: Schaus
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004987:Ethers / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry*; D015394:Molecular Structure; D010984:Platinum / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001572:Benzofurans; D004987:Ethers; D047309:Flavones; D010984:Platinum