title: Sjögren syndrome presenting with hypopotassemic periodic paralysis due to renal tubular acidosis.
abstract: BACKGROUND
  Sjögren syndrome (SS) is an autoimmune-lymphoproliferative disorder characterized by mononuclear cell infiltration of exocrine glands. Clinically, Sjögren syndrome (SS) has a wide spectrum, varying from autoimmune exocrinopathy to systemic involvement. There have been few cases reporting that primary SS developed with distal renal tubular acidosis clinically.
  
  
  METHODS
  Here, we present a case with primary Sjögren syndrome accompanied by hypopotassemic paralysis due to renal tubular acidosis. Severe hypopotassemia, hyperchloremic metabolic acidosis, alkaline urine and disorder in urinary acidification test were observed in the biochemical examination of the 16-year-old female patient, who had applied to our clinic for extreme loss of muscle force. After the examinations it was determined that the patient had developed Type 1 RTA (distal RTA) due to primary Sjögren syndrome. Potassium and alkaline replacement was made and an immediate total recovery was achieved.
  
  
  CONCLUSIONS
  Hypopotassemic paralysis due to primary Sjögren syndrome is a rare but severe disorder that could lead to death if not detected early and cured appropriately. Thus, effective treatment should be immediately initiated in cases where severe hypopotassemia is accompanied by metabolic acidosis, and the cases should also be examined for extraglandular involvement of SS.
authors.affiliation: 4 Clinic of Internal Medicine, Haseki Training and Research Hospital, Haseki Millet Caddesi, Aksaray, Turkey.
authors.forename: Esra Hayriye
authors.initials: EH
authors.lastname: Ataoglu
authors.forename: Betul
authors.initials: B
authors.lastname: Demir
authors.forename: Mazhar
authors.initials: M
authors.lastname: Tuna
authors.forename: Bilger
authors.initials: B
authors.lastname: Cavus
authors.forename: Faik
authors.initials: F
authors.lastname: Cetin
authors.forename: Levent Umit
authors.initials: LU
authors.lastname: Temiz
authors.forename: Savas
authors.initials: S
authors.lastname: Ozturk
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yenigun
keywords: Sjögren syndrome; distal renal tubular acidosis; hypopotassemic paralysis