title: Association between regulated upon activation, normal T cells expressed and secreted (RANTES) -28C/G polymorphism and susceptibility to HIV-1 infection: a meta-analysis.
abstract: BACKGROUND
  Many studies have investigated the distributions of RANTES genotypes between HIV-1 infected patients and uninfected individuals. However, no definite results have been put forward about whether the RANTES -28C/G polymorphism can affect HIV-1 susceptibility.
  
  
  METHODS
  We performed a meta-analysis of 12 studies including 7473 subjects for whom the RANTES -28C/G polymorphism was genotyped. Odds ratios (ORs) with 95% confidence intervals (CIs) were employed to assess the association of the polymorphism with HIV-1 susceptibility. By dividing the controls into healthy controls and HIV-1 exposed but seronegative (HESN) controls, we explored the both allelic and dominant genetic models.
  
  
  RESULTS
  By using the healthy controls, we found a marginally significant association between the -28C/G polymorphism and susceptibility to HIV-1 infection in the allelic model (OR = 0.82, 95%CI = 0.70-0.97). But sensitivity analysis suggested that the association was driven by one study. We further performed stratified analysis according to ethnicity. The -28G allele decreased susceptibility to HIV-1 infection in the allelic model among Asians (OR = 0.79, 95%CI = 0.66-0.94). By using the HESN controls, no association between the polymorphism -28C/G and the susceptibility to HIV-1 infection was revealed in either the allelic model (OR = 0.84, 95%CI = 0.60-1.17) or the dominant model (OR = 0.77, 95%CI = 0.54-1.10).
  
  
  CONCLUSIONS
  Our findings suggested that the RANTES -28G allele might play a role in resistance to HIV-1 infection among Asians. Additional well-designed studies were required for the validation of this association.
authors.affiliation: Department of Public Health, Center for Disease Control and Prevention in Jiangxi Province, Nanchang, China.
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Gong
authors.forename: Jialin
authors.initials: J
authors.lastname: Tang
authors.forename: Tianxin
authors.initials: T
authors.lastname: Xiang
authors.forename: Lunli
authors.initials: L
authors.lastname: Zhang
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Liao
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Yalin
authors.initials: Y
authors.lastname: Wang
mesh_terms: D018946:Chemokine CCL5 / Q000235:genetics* / Q000378:metabolism*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015658:HIV Infections / Q000208:ethnology / Q000235:genetics*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: C483024:CCL5 protein, human; D018946:Chemokine CCL5