title: Hyrtimomines A-C, new heteroaromatic alkaloids from a sponge Hyrtios sp.
abstract: Three new alkaloids, hyrtimomines A-C (1-3), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1-3 were elucidated on the basis of spectroscopic analysis and application of a phenylglycine methyl ester (PGME) method. Hyrtimomines A (1) and B (2) are heteroaromatic alkaloids possessing a fused hexacyclic 6/5/6/6/7/5 ring system, while hyrtimomine C (3) is an alkaloid consisting of hydroxyindole and azepino-hydroxyindole moieties. Hyrtimomine A (1) exhibited cytotoxicity against KB and L1210 cells.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Rei
authors.initials: R
authors.lastname: Momose
authors.forename: Naonobu
authors.initials: N
authors.lastname: Tanaka
authors.forename: Jane
authors.initials: J
authors.lastname: Fromont
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007564:Japan; D007624:KB Cells; D007939:Leukemia L1210; D008386:Marine Biology; D015394:Molecular Structure; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D011409:Propylene Glycols; C582943:hyrtimomine A; C582944:hyrtimomine B; C582945:hyrtimomine C; C005216:propylene glycol methyl ether