title: Is breast cancer in young Asian women more aggressive than in Caucasians? A cross-sectional analysis.
abstract: Ethnic differences in breast cancer are well described in studies comparing Hispanic and African-American populations to Caucasian populations. The aim of this study was to analyze the biological characteristics of breast cancer (BC) in the young Asian/Han Chinese population compared to Caucasians/Central Europeans. Histopathologies of 642 invasive BC in women at the age of 40 years and younger were analyzed in China and Austria. Pearson's chi-squared test was used to assess differences in the analyzed populations. Significantly larger BC >2 cm (p < 0.0001) and poorly differentiated BC (p = 0.02) as well as more triple-negative BC (p = 0.002) were identified among the Han Chinese group compared to the Central European group. This analysis will provide ethnic-specific insight into the biological characteristics of BC in young patients worldwide.
authors.affiliation: Department of Breast Surgery, Shanghai Cancer Institute, Fudan University, Shanghai, China. muy-kheng.tea@meduniwien.ac.at
authors.forename: Muy-Kheng M
authors.initials: MK
authors.lastname: Tea
authors.forename: Lei
authors.initials: L
authors.lastname: Fan
authors.forename: James W
authors.initials: JW
authors.lastname: Delancey
authors.forename: Christine
authors.initials: C
authors.lastname: Staudigl
authors.forename: Stefan
authors.initials: S
authors.lastname: Steurer
authors.forename: Christina
authors.initials: C
authors.lastname: Lang
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Shao
authors.forename: Christian F
authors.initials: CF
authors.lastname: Singer
mesh_terms: D000328:Adult; D044466:Asian People; D001943:Breast Neoplasms / Q000208:ethnology* / Q000473:pathology / Q000601:surgery; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D011960:Receptors, Estrogen / Q000378:metabolism; D016896:Treatment Outcome; D044465:White People; D055815:Young Adult
chemical_list: D011960:Receptors, Estrogen