title: AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease.
abstract: Alzheimer's disease (AD) is a neurodegenerative disease that proceeds with the age-dependent neuronal loss, an irreversible event which causes severe cognitive and psychiatric devastations. In the present study, we investigated whether the compound, AAD-2004 [2-hydroxy-5-[2-(4-trifluoromethylphenyl)-ethylaminobenzoic acid] which has anti-oxidant and anti-inflammatory properties, is beneficial for the brain of Tg-betaCTF99/B6 mice, a murine AD model that was recently developed to display age-dependent neuronal loss and neuritic atrophy in the brain. Administration of AAD-2004 in Tg-betaCTF99/B6 mice from 10 months to 18 months of age completely repressed the accumulation of lipid peroxidation in the brain. AAD-2004 markedly suppressed neuronal loss and neuritic atrophy, and partially reversed depleted expression of calbindin in the brain of Tg-beta-CTF99/B6. These results suggest that AAD-2004 affords neurodegeneration in the brain of AD mouse model.
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea.
authors.forename: In-Sun
authors.initials: IS
authors.lastname: Baek
authors.forename: Tae-Kyung
authors.initials: TK
authors.lastname: Kim
authors.forename: Ji-Seon
authors.initials: JS
authors.lastname: Seo
authors.forename: Kang-Woo
authors.initials: KW
authors.lastname: Lee
authors.forename: Young Ae
authors.initials: YA
authors.lastname: Lee
authors.forename: Jaeyoung
authors.initials: J
authors.lastname: Cho
authors.forename: Byoung Joo
authors.initials: BJ
authors.lastname: Gwag
authors.forename: Pyung-Lim
authors.initials: PL
authors.lastname: Han
keywords: Alzheimer's disease; neuritic atrophy; neuronal loss; neuroprotection; small molecule