title: Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes.
abstract: Multi-parametric flow cytometry was used to study lymphocyte subsets and dendritic cells in paired blood and CSF samples from 11 newly diagnosed patients with progressive anti-Hu antibody associated paraneoplastic neurological syndromes (Hu-PNS), 9 patients with other inflammatory neurologic disorders (IND), and 12 patients with other non-inflammatory neurologic disorders (OND). Hu-PNS patients had elevated numbers of regulatory T cells, central memory T cells, class-switched B cells and dendritic cells in their CSF. These findings support the hypothesis that the immune system is locally activated in Hu-PNS, and suggests common etiological pathways between Hu-PNS and other inflammatory central nervous system disorders.
authors.affiliation: Department of Medical Oncology, Erasmus University Medical Center/Daniel Den Hoed Cancer Center, Rotterdam, The Netherlands.
authors.forename: Adriaan H C
authors.initials: AH
authors.lastname: de Jongste
authors.forename: Marieke T
authors.initials: MT
authors.lastname: de Graaf
authors.forename: Patricia D M
authors.initials: PD
authors.lastname: van den Broek
authors.forename: Jaco
authors.initials: J
authors.lastname: Kraan
authors.forename: Peter A E Sillevis
authors.initials: PA
authors.lastname: Smitt
authors.forename: Jan W
authors.initials: JW
authors.lastname: Gratama
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002452:Cell Count; D002454:Cell Differentiation / Q000276:immunology; D051959:ELAV Proteins / Q000276:immunology; D005434:Flow Cytometry; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000097:blood / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D051959:ELAV Proteins