title: Aiming at neuroblastoma and hitting other worthy targets.
abstract: Neuroblastoma is, at once, the most common and deadly extracranial solid tumor of childhood. Efforts aimed at targeting the neural characteristics of these tumors have taught us much about neural crest cell biology, apoptosis induction in the nervous system, and neurotrophin receptor signaling and intracellular processing. But neuroblastoma remains a formidable enemy to the oncologist and an enigmatic target to the neuroscientist.
authors.affiliation: Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. nina_schor@urmc.rochester.edu
authors.forename: Nina F
authors.initials: NF
authors.lastname: Schor
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D002648:Child; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009432:Neural Crest / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D009447:Neuroblastoma / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D057285:Precision Medicine / Q000379:methods; D017475:Receptors, Nerve Growth Factor / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D017475:Receptors, Nerve Growth Factor
keywords: apoptosis; neural crest tumors; neurotrophin receptors