title: Cutaneous features of Crouzon syndrome with acanthosis nigricans.
abstract: OBJECTIVE
  Crouzon syndrome with acanthosis nigricans is a distinct disorder caused by a mutation in the FGFR3 gene, featuring craniosynostosis, characteristic facial features, and atypical and extensive acanthosis nigricans. Other cutaneous findings have not been thoroughly described.
  
  
  METHODS
  We report 6 cases and summarize the existing literature with regard to the cutaneous manifestations of this disorder. All patients have widespread, early-onset acanthosis nigricans. Patients often have prominent hypopigmented scars at surgical sites and nevi arising early in childhood.
  
  
  CONCLUSIONS
  In addition to craniofacial malformations, Crouzon syndrome with acanthosis nigricans results in characteristic cutaneous findings.
authors.affiliation: The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 240 E 38th St, 11th Floor, New York, NY 10016, USA.
authors.forename: Adnan
authors.initials: A
authors.lastname: Mir
authors.forename: Timothy
authors.initials: T
authors.lastname: Wu
authors.forename: Seth J
authors.initials: SJ
authors.lastname: Orlow
mesh_terms: D000052:Acanthosis Nigricans / Q000473:pathology*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000209:etiology*; D003394:Craniofacial Dysostosis / Q000473:pathology*; D005260:Female; D006801:Humans; D017496:Hypopigmentation / Q000209:etiology*; D008297:Male; D009154:Mutation; D009506:Nevus / Q000473:pathology; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics
chemical_list: C496365:FGFR3 protein, human; D051498:Receptor, Fibroblast Growth Factor, Type 3