title: Spontaneous Regression of Polyposis following Abdominal Colectomy and Helicobacter pylori Eradication for Cronkhite-Canada Syndrome.
abstract: The etiology of Cronkhite-Canada syndrome (CCS) remains unknown and many cases are refractory to treatment. Therefore, new therapies are urgently needed. Furthermore, a number of CCS cases with gastrointestinal carcinoma have been reported. Our patient had rapid onset of CCS and early development of colon carcinoma associated with adenomas. High anterior resection of the sigmoid colon and ileostomy were performed, and her symptoms and endoscopic and histological findings improved. Helicobacter pylori eradication was carried out 2 years later, surgical closure of an ileal fistula the following year. After 4 months, upper gastrointestinal endoscopy and colonoscopy showed that the CCS lesions had completely disappeared, and biopsies confirmed a normal stomach, duodenum, ileum and colon histologically. The patient has maintained remission for 2 years. The clinical course of this case, showing complete regression of CCS lesions following abdominal colectomy and H. pylori eradication, suggests the significance of H. pylori infection in the treatment of CCS.
authors.affiliation: Division of General Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Kimitoshi
authors.initials: K
authors.lastname: Kato
authors.forename: Yukimoto
authors.initials: Y
authors.lastname: Ishii
authors.forename: Takerou
authors.initials: T
authors.lastname: Mazaki
authors.forename: Toshiki
authors.initials: T
authors.lastname: Uehara
authors.forename: Hitomoi
authors.initials: H
authors.lastname: Nakamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kikuchi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yamagami
authors.forename: Hideki
authors.initials: H
authors.lastname: Sato
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Mizuno
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Soma
authors.forename: Akihiro
authors.initials: A
authors.lastname: Henmi
authors.forename: Hideki
authors.initials: H
authors.lastname: Masuda
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Moriyama
authors.forename: Masanori
authors.initials: M
authors.lastname: Tanaka
keywords: Abdominal colectomy; Colonic carcinoma; Cronkhite-Canada syndrome; Helicobacter pylori eradication; Spontaneous regression