title: Influenza C virus–associated community-acquired pneumonia in children.
abstract: To evaluate the impact of influenza C (ICV) infection in children with community-acquired pneumonia (CAP), all of the children consecutively seen during 4 influenza seasons with respiratory symptoms and radiographically confirmed CAP were prospectively evaluated. ICV was identified in the respiratory secretions of five of 391 patients (1·3%). In children with ICV-associated CAP, clinical data were similar to those observed in children with IAV-associated CAP and worse than those observed in children with IBV-associated. The phylogenetic tree showed that the sequenced strains clustered in two of the six ICV lineages. These findings highlight that ICV can be a cause of CAP of children and that this can be severe enough to require hospitalization.
authors.forename: Nicola
authors.initials: N
authors.lastname: Principi
authors.forename: Alessia
authors.initials: A
authors.lastname: Scala
authors.forename: Cristina
authors.initials: C
authors.lastname: Daleno
authors.forename: Susanna
authors.initials: S
authors.lastname: Esposito
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D017714:Community-Acquired Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D005260:Female; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D009982:Gammainfluenzavirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D011024:Pneumonia, Viral / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D012367:RNA, Viral / Q000235:genetics; D013902:Radiography, Thoracic; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D012367:RNA, Viral