title: Bispecific antibodies for delivery into the brain.
abstract: The blood-brain barrier (BBB) is a formidable obstacle preventing drug delivery to the brain, particularly for large protein therapeutics. The utilization of endogenous brain endothelial transport pathways, however, represents a promising approach to cross the cellular barrier through receptor-mediated transcytosis. Therapeutics designed to take advantage of this approach require at least two functionalities, one that facilitates transport and the other to provide therapeutic benefit, and bispecific antibodies are ideally suited for this task.
authors.affiliation: Neurodegeneration Labs, Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, United States.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Watts
authors.forename: Mark S
authors.initials: MS
authors.lastname: Dennis
mesh_terms: D000818:Animals; D018033:Antibodies, Bispecific / Q000378:metabolism* / Q000627:therapeutic use; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D021381:Protein Transport; D011956:Receptors, Cell Surface / Q000378:metabolism; D057900:Transcytosis
chemical_list: D018033:Antibodies, Bispecific; D011956:Receptors, Cell Surface