title: Coexistence of gastrointestinal stromal tumor, esophageal and gastric cardia carcinomas.
abstract: Gastric gastrointestinal stromal tumor (GIST), esophageal squamous cell carcinoma and gastric cardia adenocarcinoma are distinct neoplasms originating from different cell layers; therefore, simultaneous development of such carcinomas is relatively rare. Auxiliary examinations revealed coexistence of esophageal and gastric cardia carcinoma with lymph node metastasis in a 77-year-old man. Intraoperatively, an extraluminal tumor (about 6.0 cm × 5.0 cm × 6.0 cm) at the posterior wall of the gastric body, a tumor (about 2.5 cm × 2.0 cm) in the lower esophagus, and an infiltrative and stenosing tumor (about 1.0 cm × 2.0 cm) in the gastric cardia were detected. Wedge resection for extraluminal gastric tumor, radical esophagectomy for lower esophageal tumor, and cardiac resection with gastroesophageal (supra-aortic arch anastomoses) were performed. Postoperative histological examination showed synchronous occurrence of gastric GIST, esophageal squamous cell carcinoma, and gastric cardia adenocarcinoma. Furthermore, immunohistochemistry indicated strong staining for c-Kit/CD117, Dog-1, Ki-67 and smooth muscle, while expression of S-100 and CD34 was negative.
authors.affiliation: Department of General Surgery, Yancheng City No.1 People's Hospital, Yancheng 224005, Jiangsu Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Wu
authors.forename: Quan
authors.initials: Q
authors.lastname: Shi
authors.forename: Jing
authors.initials: J
authors.lastname: Jia
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis*; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*
keywords: Esophageal squamous cell carcinoma; Gastric cardia adenocarcinoma; Gastrointestinal stromal tumor