title: [Molecular mechanism research on simultaneous therapy of brain and heart based on data mining and network analysis].
abstract: OBJECTIVE
  The theory of treating heart and brain simultaneously is from the theory of traditional Chinese medicine, and there aren't enough explanations for this theory from the perspective of molecular mechanism. As one successful case of this theory, the Chinese medicine formula--Buchang Naoxintong can achieve the goal of treating coronary heart disease and stroke at the same time. To illustrate the mechanism of the theory of treating heart and brain simultaneously, it is necessary to find out the molecular mechanism of this formula.
  
  
  METHODS
  Using the network analysis method, together with two data mining methods-clustering and apriori algorithm, the frequent gene combinations interfered by the chemicals of the formula based on the protein-protein interaction networks related with coronary heart disease and stroke disease were figured out respectively. To find out the molecular mechanism of the theory of treating heart and brain simultaneously, the results got from two diseases were compared and analyzed.
  
  
  RESULTS
  Based on comparing two results from these two different diseases, the mechanism of the theory of treating heart and brain simultaneously was explained from molecular level by finding out key genes targeted by the components of this formula for both diseases and some particular genes interfered by the components for each disease. In addition, genes interfered indirectly by the chemicals for different diseases were found out based on the protein-protein interaction network.
  
  
  CONCLUSIONS
  It can help to explain the molecular mechanism of the theory by our methods. By finding out the molecular mechanism of this theory, it can promote the progress of combination of Chinese traditional and Western medicine.
authors.affiliation: Institute of Automation, Chinese Academy of Science, Beijing 100190, China. di.chen@ia.ac.cn
authors.forename: Di
authors.initials: D
authors.lastname: Chen
authors.forename: Peng
authors.initials: P
authors.lastname: Lu
authors.forename: Fang-Bo
authors.initials: FB
authors.lastname: Zhang
authors.forename: Shi-Huan
authors.initials: SH
authors.lastname: Tang
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Yang
mesh_terms: D003327:Coronary Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D057225:Data Mining; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006801:Humans; D011485:Protein Binding; D060066:Protein Interaction Maps / Q000187:drug effects*; D020521:Stroke / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*
chemical_list: D004365:Drugs, Chinese Herbal; C533635:buchang naoxintong