title: Stimulation of A2B adenosine receptors protects against trauma-hemorrhagic shock-induced lung injury.
abstract: Inflammation is responsible for secondary organ failure after trauma and hemorrhagic shock (T/HS). Adenosine, acting through four G protein-coupled cell surface receptors, A1, A2A, A2B, and A3, exerts a number of tissue protective and anti-inflammatory effects. The goal of the present study was to test the effect of A2B adenosine receptor stimulation on T/HS-induced organ injury and inflammation in rats. Rats after T/HS were resuscitated with Ringer's lactate containing the A2B receptor agonist BAY 60-6583 or its vehicle. We found that BAY 60-6583 decreased T/HS-induced lung permeability and plasma creatine kinase levels but failed to affect T/HS-induced lung neutrophil infiltration and IκBα expression and plasma alanine aminotransferase levels. Thus, we conclude that stimulation of A2B receptors protects against T/HS-induced lung and muscle injury.
authors.affiliation: Department of Surgery, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 07103, USA.
authors.forename: Balázs
authors.initials: B
authors.lastname: Koscsó
authors.forename: Alexey
authors.initials: A
authors.lastname: Trepakov
authors.forename: Balázs
authors.initials: B
authors.lastname: Csóka
authors.forename: Zoltán H
authors.initials: ZH
authors.lastname: Németh
authors.forename: Pál
authors.initials: P
authors.lastname: Pacher
authors.forename: Holger K
authors.initials: HK
authors.lastname: Eltzschig
authors.forename: György
authors.initials: G
authors.lastname: Haskó
mesh_terms: D055371:Acute Lung Injury / Q000378:metabolism*; D000631:Aminopyridines / Q000494:pharmacology; D000818:Animals; D015153:Blotting, Western; D004195:Disease Models, Animal; D007249:Inflammation / Q000378:metabolism*; D008297:Male; D058906:Purinergic P1 Receptor Agonists / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D043704:Receptor, Adenosine A2B / Q000378:metabolism*; D012771:Shock, Hemorrhagic / Q000378:metabolism*; D014947:Wounds and Injuries
chemical_list: D000631:Aminopyridines; C518875:BAY 60-6583; D058906:Purinergic P1 Receptor Agonists; D043704:Receptor, Adenosine A2B