title: Acute bilateral endophthalmitis following bilateral intravitreal bevacizumab (avastin) injection.
abstract: The clinical presentation and management of two patients who presented with acute bilateral endophthalmitis following bilateral intravitreal bevacizumab injection. Both cases were diagnosed clinically and subsequent to a vitreous sample, intravitreal ceftazidime (2.25 mg/0.1 ml) and vancomycin (1 mg/0.1 ml) were injected. One patient had a significant improvement in signs and symptoms after intravitreal antibiotics. However, there were was no improvement in the other patient and pars plana vitrectomy was performed bilaterally. Vitreous cultures were positive in both cases for Staphylococcus epidermidis.
authors.affiliation: Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Tabatabaii
authors.forename: Aliasghar
authors.initials: A
authors.lastname: Ahmadraji
authors.forename: Alireza
authors.initials: A
authors.lastname: Khodabande
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Mansouri
mesh_terms: D000208:Acute Disease; D000368:Aged; D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D000068258:Bevacizumab; D002442:Ceftazidime / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013212:Staphylococcus epidermidis / Q000302:isolation & purification; D014640:Vancomycin / Q000627:therapeutic use; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014821:Vitrectomy; D014822:Vitreous Body / Q000382:microbiology
chemical_list: D020533:Angiogenesis Inhibitors; D000900:Anti-Bacterial Agents; D061067:Antibodies, Monoclonal, Humanized; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab; D014640:Vancomycin; D002442:Ceftazidime
keywords: Bevacizumab; Endophthalmitis; Intravitreal Injection