title: The role of the mTOR pathway during liver regeneration and tumorigenesis.
abstract: It is established that overnutrition is a risk factor for hepatocellular carcinoma. Il has been proposed that hepatic steatosis leads to a subinflammatory response and to the production of mitogenic cytokines. Our team is focused on the role of mammalian Target of Rapamycin (mTOR) in two pathophysiological conditions that modulate liver growth: liver regeneration after partial hepatectomy, and steatosis-associated tumorigenesis. Target kinases of mTOR seem more specifically involved in these processes: while S6K1 contributes to liver regeneration following hepatectomy, Akt2 is implicated in steatosis-associated tumorigenesis. In addition, recent data indicate that the transcription factor PPARγ, through an activation of glycolytic enzymes, could promote liver steatosis, hypertrophy and hyperplasia.
authors.affiliation: Inserm U845, Paris Descartes University, 96, rue Didot, 75014 Paris, France.
authors.forename: Ganna
authors.initials: G
authors.lastname: Panasyuk
authors.forename: Cecilia
authors.initials: C
authors.lastname: Patitucci
authors.forename: Catherine
authors.initials: C
authors.lastname: Espeillac
authors.forename: Mario
authors.initials: M
authors.lastname: Pende
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D005234:Fatty Liver / Q000150:complications / Q000473:pathology; D006498:Hepatectomy / Q000009:adverse effects / Q000534:rehabilitation; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D008115:Liver Regeneration / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases