title: [Development of overweight and obesity in breast cancer patients and its significance for diagnosis and clinical management: results of the Basel Breast Cancer Database 1990-2009].
abstract: Greater body fatness was found to be a risk factor for postmenopausal breast cancer (BC); furthermore this factor appears to be associated with poor prognosis. These findings were tested by analyzing 1459 patients whose cases were recorded in the Basler Mammakarzinom-Datenbank (1990-2009) and the Swiss Health Surveys (1992-2007). Considering only postmenopausal women, no association between a rising body mass index (BMI) and BC development was observed. BMI was found to be a significant factor for tumor size (this applied to self-detected tumors and for lesions detected by radiological examinations) and had a positive correlation to advanced disease stage, unfavorable grading and a higher St. Galler risk score. In most therapy modes, patients with increasing BMI demonstrated a higher compliance and persistence to adjuvant therapies.
authors.affiliation: Departement für Geburtshilfe und Gynäkologie, Brustzentrum «SenoSuisse» und Universitätsspital Basel, Frauenklinik. uwe.gueth@unibas.ch
authors.forename: Uwe
authors.initials: U
authors.lastname: Güth
authors.forename: Seraina
authors.initials: S
authors.lastname: Schmid
authors.forename: Monika
authors.initials: M
authors.lastname: Eichholzer
mesh_terms: D000368:Aged; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009765:Obesity / Q000150:complications / Q000453:epidemiology*; D050177:Overweight / Q000150:complications / Q000453:epidemiology*; D010349:Patient Compliance; D017698:Postmenopause; D011379:Prognosis; D013223:Statistics as Topic; D013557:Switzerland