title: Magnesium homeostasis in Mammalian cells.
abstract: Magnesium, the second most abundant cation within the cell, plays an important role in numerous biological functions. Experimental evidence indicates that mammalian cells tightly regulate cellular magnesium ion content through specific mechanisms controlling Mg(2+) entry and efflux across the cell membrane and the membrane of various cellular organelles as well as intracellular Mg(2+) buffering under resting conditions and following hormonal and metabolic stimuli. This chapter will provide an assessment of the various mechanisms controlling cellular Mg(2+) homeostasis and transport, and the implications changes in cellular Mg(2+) content play under physiological and pathological conditions.
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106-4970, USA, amr5@po.cwruy.edu.
authors.forename: Andrea M P
authors.initials: AM
authors.lastname: Romani
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008274:Magnesium / Q000378:metabolism
chemical_list: D008274:Magnesium