title: In vivo acquired daptomycin resistance during treatment of methicillin-resistant Staphylococcus aureus endocarditis.
abstract: This clinical case reports the emergence of a daptomycin-resistant Staphylococcus aureus isolate during daptomycin treatment in a patient with right-sided infective endocarditis who had never been treated with vancomycin.
authors.affiliation: Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre, France; INSERM U914 "Emerging Resistance to Antibiotics", Faculté de Médecine Paris Sud, Le Kremlin-Bicêtre, France. Electronic address: laurent.dortet@bct.aphp.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Dortet
authors.forename: Nadia
authors.initials: N
authors.lastname: Anguel
authors.forename: Nicolas
authors.initials: N
authors.lastname: Fortineau
authors.forename: Christian
authors.initials: C
authors.lastname: Richard
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017576:Daptomycin / Q000494:pharmacology / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin
keywords: Daptomycin resistance; Endocarditis; Methicillin-resistant Staphylococcus aureus; Septicemia