title: Reexposure to the amnestic agent alleviates cycloheximide-induced retrograde amnesia for reactivated and extinction memories.
abstract: We investigated whether reexposure to an amnestic agent would reverse amnesia for extinction of learned fear similar to that of a reactivated memory. When cycloheximide (CHX) was administered immediately after a brief cue-induced memory reactivation (15 sec) and an extended extinction session (12 min) rats showed retrograde amnesia for both memories. CHX did not produce amnesia for a moderate extinction session (6 min). Re-administering CHX before testing reversed the amnestic effect for both memories (i.e., the memories were recovered). These results are discussed using a modified state dependent model of retrograde amnesia.
authors.affiliation: Department of Psychology, Susquehanna University, Selinsgrove, PA 17870, USA. briggsj@susqu.edu
authors.forename: James F
authors.initials: JF
authors.lastname: Briggs
authors.forename: Brian P
authors.initials: BP
authors.lastname: Olson
mesh_terms: D000648:Amnesia, Retrograde / Q000139:chemically induced* / Q000188:drug therapy*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects; D003513:Cycloheximide / Q000494:pharmacology / Q000627:therapeutic use*; D005108:Extinction, Psychological / Q000187:drug effects*; D005260:Female; D008568:Memory / Q000187:drug effects*; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D003513:Cycloheximide