title: Zhizhu decoction promotes gastric emptying and protects the gastric mucosa.
abstract: The aim of this study was to evaluate the effects of the Zhizhu decoction on gastric emptying and gastric mucosal protection. The Zhizhu decoction is composed of Aurantii fructus and Atractylodes macrocephala Rhizoma. Results showed that oral administration of the Zhizhu decoction accelerated gastric emptying in mouse and protected gastric mucosa from ethanol-induced ulcers in rat. Our investigations demonstrated that the Zhizhu decoction accelerated gastric emptying, at least in part, by activating the muscarinic and 5-HT3 receptors. The gastroprotective effect is involved in its antioxidant effects and increased vascular endothelial growth factor expression.
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Ministry of Education, Tianjin, China.
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xinrui
authors.initials: X
authors.lastname: Wang
authors.forename: Lingling
authors.initials: L
authors.lastname: Guo
authors.forename: Lifeng
authors.initials: L
authors.lastname: Han
authors.forename: Erwei
authors.initials: E
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology; D031174:Atractylodes; D002957:Citrus; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004415:Dyspepsia / Q000139:chemically induced / Q000188:drug therapy*; D000431:Ethanol / Q000009:adverse effects; D005638:Fruit; D005746:Gastric Emptying / Q000187:drug effects*; D005753:Gastric Mucosa / Q000187:drug effects*; D005765:Gastrointestinal Agents / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D011976:Receptors, Muscarinic / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism; D027343:Rhizome; D013270:Stomach / Q000187:drug effects*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D000897:Anti-Ulcer Agents; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D005765:Gastrointestinal Agents; D011976:Receptors, Muscarinic; D011985:Receptors, Serotonin; D042461:Vascular Endothelial Growth Factor A; D000431:Ethanol