title: Urinary prostate-specific antigen: predictor of benign prostatic hyperplasia progression?
abstract: BACKGROUND
  Urinary prostate-specific antigen (uPSA) can be used as additional parameter of benign prostatic hyperplasia (BPH) progression.
  
  
  METHODS
  From January 2001 to December 2011, uPSA was determined in 265 patients with benign prostate. Based on total prostate volume (TPV), the patients with benign prostate were divided in two groups: TPV < 31 mL and TPV ≥ 31 mL. Additional three groups were formed upon MTOPS study criteria: non- progressive BPH group (TPV < 31 mL, PSA < 1.6 ng/mL, age < 62 yrs), intermediate group (one, or two parameters {TPV, PSA, age} increased) and progressive BPH group (TPV ≥ 31 ml, PSA ≥ 1.6 ng/mL, age ≥ 62 yrs).
  
  
  RESULTS
  Average uPSA values in the groups TPV < 31 mL and TPV ≥ 31 mL were 119.3 ± 124.5 and 255.5 ± 204.9 ng/mL, respectively and they were significantly different (p < 0.0001). Average uPSA values in the non- progressive BPH group, intermediate group and progressive BPH group were 86.8 ± 82.4 ng/mL, 166.6 ± 164.9 ng/mL and 274.9 ± 208.3 ng/mL, respectively and they were significantly different (p < 0.0001). The level of uPSA correlated significantly with TPV (r = 0.32, p < 0.0001). The cut off uPSA level of 150 ng/mL discriminates the patients with non-progressive BPH and progressive BPH with specificity of 0.83 and sensitivity of 0.67.
  
  
  CONCLUSIONS
  The level of uPSA reflects prostatic hormonal activity and correlates with TPV, PSA and age. UPSA level ≥ 150 ng/mL can be used as additional predictive parameter of BPH progression.
authors.affiliation: Clinical Center of Serbia, Urological Clinic, Belgrade, Serbia.
authors.forename: Tomislav P
authors.initials: TP
authors.lastname: Pejcic
authors.forename: Cane Dz
authors.initials: CDz
authors.lastname: Tulic
authors.forename: Natasa V
authors.initials: NV
authors.lastname: Lalic
authors.forename: Biljana D
authors.initials: BD
authors.lastname: Glisic
authors.forename: Svetlana D
authors.initials: SD
authors.lastname: Ignjatovic
authors.forename: Biljana B
authors.initials: BB
authors.lastname: Markovic
authors.forename: Jovan B
authors.initials: JB
authors.lastname: Hadzi-Djokic
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000652:urine; D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011237:Predictive Value of Tests; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000652:urine*; D011470:Prostatic Hyperplasia / Q000175:diagnosis* / Q000473:pathology / Q000652:urine*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D017430:Prostate-Specific Antigen