title: Opening up new fronts in the fight against cholesterol.
abstract: An unexpected connection between a secretory protein called PCSK9 and Sec24A, a well known protein-transport protein, could lead to the development of novel treatments for patients with high levels of low-density lipoproteins in their blood.
authors.affiliation: is at the Department of Molecular Genetics and the Howard Hughes Medical Institute , University of Texas Southwestern Medical Center , Dallas , United States Russell.Debose-Boyd@utsouthwestern.edu.
authors.forename: Russell A
authors.initials: RA
authors.lastname: Debose-Boyd
authors.forename: Jay D
authors.initials: JD
authors.lastname: Horton
mesh_terms: D000818:Animals; D022181:COP-Coated Vesicles / Q000201:enzymology*; D002784:Cholesterol / Q000097:blood*; D050171:Dyslipidemias / Q000201:enzymology*; D004721:Endoplasmic Reticulum / Q000201:enzymology*; D006801:Humans; D008099:Liver / Q000201:enzymology*; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases / Q000097:blood*; D012697:Serine Endopeptidases / Q000097:blood*; D033921:Vesicular Transport Proteins / Q000172:deficiency*
chemical_list: D033921:Vesicular Transport Proteins; D002784:Cholesterol; C472126:Pcsk9 protein, mouse; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases; D012697:Serine Endopeptidases
keywords: COP II; Cholesterol metabolism; Mouse; Secretory pathway