title: Collagen cross-linking in the treatment of pellucid marginal degeneration.
abstract: Pellucid marginal degeneration (PMD) is an uncommon cause of inferior peripheral corneal thinning disorder, characterized by irregular astigmatism. We analyzed a case of bilateral PMD patient and treated one eye with corneal collagen cross-linking (CXL) therapy. Corneal topography was characteristic for PMD. Visual acuity, slitlamp examinations, tonometry, and corneal thickness were observed. Simulated keratometric and topographic index values were detected with corneal topography. Uncorrected, LogMAR visual acuity has improved from +0.8 to +0.55 during the 6 months and +0.3 during the 8 months follow-up after CXL. Pachymetry values and intraocular pressure showed no changes. Keratometric values and topografic indexes disclosed no progression of the disease. CXL may postpone or eliminate the need of corneal transplantation in cases with PMD.
authors.affiliation: Orbident Refractive Surgery and Medical Center, University of Debrecen, Debrecen, Hungary.
authors.forename: Ziad
authors.initials: Z
authors.lastname: Hassan
authors.forename: Gabor
authors.initials: G
authors.lastname: Nemeth
authors.forename: Laszlo
authors.initials: L
authors.lastname: Modis
authors.forename: Eszter
authors.initials: E
authors.lastname: Szalai
authors.forename: Andras
authors.initials: A
authors.lastname: Berta
mesh_terms: D003094:Collagen / Q000627:therapeutic use*; D003317:Corneal Dystrophies, Hereditary / Q000175:diagnosis / Q000188:drug therapy*; D003319:Corneal Stroma / Q000473:pathology*; D019781:Corneal Topography; D003432:Cross-Linking Reagents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D014792:Visual Acuity
chemical_list: D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen