title: Diabetes and renal tubular cell apoptosis.
abstract: Apoptosis contributes to the development of diabetic nephropathy, but the mechanism by which high glucose induces apoptosis is not fully understood. Apoptosis of tubular epithelial cells is a major feature of diabetic kidney disease, and hyperglycemia triggers the generation of free radicals and oxidant stress in tubular cells. Hyperglycemia and high glucose in vitro also lead to apoptosis, a form of programmed cell death. High glucose similar to those seen with hyperglycemia in people with diabetes mellitus, lead to accelerated apoptosis, a form of programmed cell death characterized by cell shrinkage, chromatin condensation and DNA fragmentation, in variety of cell types, including renal proximal tubular epithelial cells.
authors.affiliation: Samy L Habib, South Texas Veterans Health Care System, Departments of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, United States.
authors.forename: Samy L
authors.initials: SL
authors.lastname: Habib
keywords: Apoptosis; Diabetes; Renal; Tubular cells