title: α-Oxo aldehyde or glyoxylyl group chemistry in peptide bioconjugation.
abstract: Since the 1990s, α-oxo aldehyde or glyoxylic acid chemistry has inspired a vast array of synthetic tools for tailoring peptide or protein structures, for developing peptides endowed with novel physicochemical properties or biological functions, for assembling a large diversity of bioconjugates or hybrid materials, or for designing peptide-based micro or nanosystems. This past decade, important developments have enriched the α-oxo aldehyde synthetic tool box in peptide bioconjugation chemistry and explored novel applications. The aim of this review is to give a large overview of this creative field.
authors.affiliation: Université Sidi Mohamed Ben Abdellah, Faculté Polydisciplinaire de Taza, Morocco.
authors.forename: Ouafâa
authors.initials: O
authors.lastname: El-Mahdi
authors.forename: Oleg
authors.initials: O
authors.lastname: Melnyk
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry*; D000595:Amino Acid Sequence; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006038:Glyoxylates / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D006038:Glyoxylates; D010455:Peptides; C031150:glyoxylic acid