title: Peripheral neuropathy incidence in inflammatory bowel disease: a population-based study.
abstract: OBJECTIVE
  Our aim was to determine the incidence of peripheral neuropathy in a population-based inflammatory bowel disease (IBD) cohort from Olmsted County, Minnesota.
  
  
  METHODS
  We retrospectively ascertained neuropathy incidence in a population-based cohort of adult persons newly diagnosed with IBD between 1940 and 2004 in Olmsted County, Minnesota, using the medical records linkage system of the Rochester Epidemiology Project. The Kaplan-Meier method was used to estimate the cumulative incidence of neuropathy.
  
  
  RESULTS
  A total of 772 Olmsted County residents aged 18 to 91 years were diagnosed with IBD. After 12,476 person-years, 9 patients developed neuropathy, providing an overall incidence rate of 72 (95% confidence interval [CI] 33-137) cases per 100,000 IBD person-years. The cumulative incidence rates after 10, 20, and 30 years were 0.7% (95% CI 0.0%-1.3%), 0.7% (95% CI 0.0%-1.5%), and 2.4% (95% CI 0.6%-4.6%), respectively. Neuropathy was diagnosed after 1 to 44 years from IBD onset. Only 2 patients had active bowel disease at the time of neuropathy onset. The clinical spectrum consisted of 1) monophasic immune radiculoplexus neuropathy (comorbid diabetes in 2 of 4 patients) and 2) chronic distal sensorimotor polyneuropathy (comorbid diabetes in 2 of 5 patients).
  
  
  CONCLUSIONS
  Our population-based study suggests that neuropathy is uncommon in the patient population of IBD. Radiculoplexus neuropathy and sensorimotor polyneuropathy were both observed, commonly during periods of bowel disease inactivity. Clinicians should consider other etiologies of neuropathy in patients with IBD.
authors.affiliation: Department of Neurology, Peripheral Nerve Laboratory, Rochester Epidemiology Project, Mayo Clinic, Rochester, MN, USA. figueroa.juan@mail.com
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Figueroa
authors.forename: Edward V
authors.initials: EV
authors.lastname: Loftus
authors.forename: William S
authors.initials: WS
authors.lastname: Harmsen
authors.forename: P James B
authors.initials: PJ
authors.lastname: Dyck
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Klein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003093:Colitis, Ulcerative / Q000453:epidemiology*; D003424:Crohn Disease / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D010523:Peripheral Nervous System Diseases / Q000453:epidemiology*; D012189:Retrospective Studies; D055815:Young Adult