title: Techniques and materials for enhancement of peripheral nerve regeneration: a literature review.
abstract: Peripheral nerve surgery performed under unfavorable conditions results in increased scar formation and suboptimal clinical outcomes. Providing the operated nerve with a protective barrier, reduces fibrosis and adhesion formation and may lead to improved outcomes. The ideal coverage material should prevent scar and adhesion formation, and maintain nerve gliding during motion. Nerve protection using autologous tissues has shown good results, but shortcomings include donor site morbidity and limited availability. Various types of methods and materials have been used to protect nerves. There are both advantages and disadvantages associated with the various materials and techniques. In this report we summarize currently used protective materials applied for nerve coverage under various surgical conditions.
authors.affiliation: Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA. siemiom@ccf.org
authors.forename: Maria
authors.initials: M
authors.lastname: Siemionow
authors.forename: Safak
authors.initials: S
authors.lastname: Uygur
authors.forename: Can
authors.initials: C
authors.lastname: Ozturk
authors.forename: Kris
authors.initials: K
authors.lastname: Siemionow
mesh_terms: D020341:Absorbable Implants; D000273:Adipose Tissue / Q000637:transplantation; D000650:Amnion; D003094:Collagen; D005109:Extracellular Matrix; D048091:Guided Tissue Regeneration / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D009416:Nerve Regeneration; D019635:Neurosurgical Procedures / Q000295:instrumentation / Q000379:methods*; D010525:Peripheral Nerves / Q000502:physiology / Q000601:surgery*; D012828:Silicones; D013524:Surgical Flaps; D014680:Veins / Q000637:transplantation
chemical_list: D012828:Silicones; D003094:Collagen