title: All the commercially available adhesion barriers have the same effect on adhesion prophylaxis?; A comparison of barrier agents using a newly developed, severe intra-abdominal adhesion model.
abstract: BACKGROUND
  Various types of adhesion barriers are widely used to prevent intra-abdominal adhesion. However, few studies have compared the efficacy of adhesion barriers using the same animal model. The aim of this study was to compare the anti-adhesive effects of various barrier agents using a newly developed, severe adhesion model.
  
  
  METHODS
  A severe adhesion model was established by excision of a 1-cm(2) intra-abdominal wall and application of cyanoacrylate in rat. Eighty male Sprague-Dawley rats (10 weeks old; 370 ± 50 g) were divided randomly into four groups (n = 20 each): the untreated control group, G-group using a hyaluronic acid and sodium carboxymethyl cellulose gel (Guardix-sol®), A-group using 4% icodextrin (Adept®), and S-group using a hyaluronate-carboxymethyl cellulose membrane (Seprafilm®). The effect of each adhesion barrier was evaluated by means of the extent and severity of adhesion, difficulty of adhesiolysis scoring systems, and microscopic grade of fibrosis.
  
  
  RESULTS
  The G-group showed no difference in adhesion score and fibrosis, the A-group demonstrated only a significantly lower fibrosis, and the S-group exhibited a significantly lower adhesion score and lower fibrosis compared with the control group. The S-group had a significantly lower adhesion score and reduced fibrosis compared with the G-group; however, no significant difference in adhesion score and fibrosis was noted with the A-group.
  
  
  CONCLUSIONS
  The membranous barrier Seprafilm® may be effective in the prevention of adhesion in the condition of peritoneal injury combined with foreign material. Adept® showed a tendency of decreasing the severity of adhesion and was effective in the prevention of fibrosis.
authors.affiliation: Department of Surgery, Busan Paik Hospital, Inje University College of Medicine, 633-165 Gaegum-dong, Jin-gu, Busan 614-735, Republic of Korea.
authors.forename: Hyo Jun
authors.initials: HJ
authors.lastname: Hwang
authors.forename: Min Sung
authors.initials: MS
authors.lastname: An
authors.forename: Tae Kwun
authors.initials: TK
authors.lastname: Ha
authors.forename: Kwang Hee
authors.initials: KH
authors.lastname: Kim
authors.forename: Tae Hyeon
authors.initials: TH
authors.lastname: Kim
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Choi
authors.forename: Kwan Hee
authors.initials: KH
authors.lastname: Hong
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Jung
authors.forename: Sun-Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Kuk Hwan
authors.initials: KH
authors.lastname: Rho
authors.forename: Ki Beom
authors.initials: KB
authors.lastname: Bae
mesh_terms: D000005:Abdomen / Q000473:pathology*; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*
chemical_list: D001672:Biocompatible Materials