title: Beneficial effect of combination therapy using an angiotensin-converting enzyme inhibitor plus verapamil on circulating resistin levels in hypertensive patients with type 2 diabetes.
abstract: BACKGROUND
  Resistin levels are strongly correlated with insulin resistance and vascular inflammation. Type 2 diabetic and hypertensive patients have higher circulating levels of resistin, which is associated with endothelial dysfunction.
  
  
  OBJECTIVE
  To compare the effect of trandolapril (T) and its fixed-dose combination with verapamil (FDTV) on resistin levels in hypertensive, type-2 diabetic patients.
  
  
  METHODS
  Forty type-2 diabetic patients with never-treated hypertension were randomly assigned to two groups. One group received FDTV 2 mg/180 mg once per day; the other group received T 2 mg once per day. Study drugs were administered for three months in both groups. Resistin levels were measured using ELISA at the beginning of the study and at study end. Patients were evaluated monthly for blood pressure, fasting serum glucose levels and adverse events. Statistical analysis was performed using ANOVA.
  
  
  RESULTS
  All patients experienced a significant reduction in blood pressure. Both therapeutic regimens reduced resistin levels; however, FDTV treatment resulted in a greater decrease in resistin levels (mean [± SD] 25.5±13 ng/mL to 17.2±10 ng/mL) when compared with T treatment (22.4±12 ng/mL to 18.5±8 ng/mL) (P<0.05). None of the patients experienced an adverse event.
  
  
  CONCLUSIONS
  Results showed that FDTV resulted in a greater reduction in resistin levels than T treatment alone.
authors.affiliation: Hypertension Clinic, Hospital General de Ticomán SS DF, Mexican Group For Basic And Clinical Research In Internal Medicine, AC;
authors.forename: Alberto F
authors.initials: AF
authors.lastname: Rubio-Guerra
authors.forename: Hilda
authors.initials: H
authors.lastname: Vargas-Robles
authors.forename: Jose J
authors.initials: JJ
authors.lastname: Lozano Nuevo
authors.forename: Cesar I
authors.initials: CI
authors.lastname: Elizalde-Barrera
authors.forename: Saul
authors.initials: S
authors.lastname: Huerta-Ramirez
authors.forename: Bruno A
authors.initials: BA
authors.lastname: Escalante-Acosta
keywords: Diabetes; Fixed-dose combination; Resistin; Trandolapril; Verapamil