title: LKB1 and AMPK and the cancer-metabolism link - ten years after.
abstract: The identification of a complex containing the tumor suppressor LKB1 as the critical upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by metabolic stress was reported in an article in Journal of Biology in 2003. This finding represented the first clear link between AMPK and cancer. Here we briefly discuss how this discovery came about, and describe some of the insights, especially into the role of AMPK in cancer, that have followed from it.
authors.affiliation: Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK. d.g.hardie@dundee.ac.uk
authors.forename: D Grahame
authors.initials: DG
authors.lastname: Hardie
authors.forename: Dario R
authors.initials: DR
authors.lastname: Alessi
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D004734:Energy Metabolism; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000517:prevention & control / Q000628:therapy; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases