title: Effects of quercetin on LPS-induced disseminated intravascular coagulation (DIC) in rabbits.
abstract: BACKGROUND
  Quercetin is widely distributed in plants and has been reported to have effects of anti-inflammation and anti-thrombosis. In this study, we evaluated the protective effect of quercetin on LPS-induced experimental DIC in rabbits, and tried to clarify its mechanism against DIC.
  
  
  METHODS
  LPS-induced DIC model in rabbits was established through continuous infusion of 100 ug · kg(-1) · h(-1) LPS for a period of 6h. Six groups were divided: quercetin-treated groups (0.5, 1.0, and 2.0 mg·kg(-1) · h(-1), respectively), LPS-control group, heparin-control group (100 IU · kg(-1) · h(-1)), and saline-control group. APTT, PT, and plasma FIB level were measured, the plasma levels of ALT, BUN, and TNF-α were detected, and the activity of Protein C and ATIII was recorded.
  
  
  RESULTS
  A continuous injection of LPS induced a gradual impairment of hemostatic parameters, a rise in plasma level of TNF-α, and damage in renal and hepatic function. The intravenous administration of quercetin significantly attenuated the increase of APTT, PT, ALT, BUN, and TNF-α, and the decrease of plasma FIB level and activity of Protein C and ATIII.
  
  
  CONCLUSIONS
  Quercetin may have a protective effect against LPS-induced DIC in rabbits through anti-inflammation and anticoagulation.
authors.affiliation: Department of Pharmacology, Medical College, Ji-nan University, Guangzhou, China.
authors.forename: Pan-xi
authors.initials: PX
authors.lastname: Yu
authors.forename: Qin-ji
authors.initials: QJ
authors.lastname: Zhou
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Zhu
authors.forename: Yu-han
authors.initials: YH
authors.lastname: Wu
authors.forename: Liang-cai
authors.initials: LC
authors.lastname: Wu
authors.forename: Xi
authors.initials: X
authors.lastname: Lin
authors.forename: Ming-hui
authors.initials: MH
authors.lastname: Chen
authors.forename: Bi-tao
authors.initials: BT
authors.lastname: Qiu
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001806:Blood Urea Nitrogen; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008070:Lipopolysaccharides; D008297:Male; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D011794:Quercetin / Q000627:therapeutic use*; D011817:Rabbits; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000975:Antioxidants; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D011794:Quercetin; D000410:Alanine Transaminase