title: Antinociceptive activity of Ricinus communis L. leaves.
abstract: OBJECTIVE
  To evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves (MRCL).
  
  
  METHODS
  Antinociceptive activity was evaluated using acetic acid induced writhing test, formalin induced paw licking and tail immersion method in mice at doses of 100, 125 and 150 mg/kg bw.
  
  
  RESULTS
  The results indicated that MRCL exhibited considerable antinociceptive activity against three classical models of pain in mice. Preliminary phytochemical analysis suggested the presence of saponin, steroids and alkaloids.
  
  
  CONCLUSIONS
  It can be concluded that MRCL possesses antinociceptive potential that may be due to saponin, steroids and alkaloids in it.
authors.affiliation: Department of Pharmacognosy, SVPM's College of Pharmacy, Malegaon (bk), Baramati, Maharashtra, India.
authors.forename: Dnyaneshwar J
authors.initials: DJ
authors.lastname: Taur
authors.forename: Maruti G
authors.initials: MG
authors.lastname: Waghmare
authors.forename: Rajendra S
authors.initials: RS
authors.lastname: Bandal
authors.forename: Ravindra Y
authors.initials: RY
authors.lastname: Patil
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage / Q000737:chemistry; D000700:Analgesics / Q000008:administration & dosage* / Q000737:chemistry; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D012278:Ricinus / Q000737:chemistry*; D012503:Saponins / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000700:Analgesics; D010936:Plant Extracts; D012503:Saponins
keywords: Analgesic; Antinociceptive; Formalin; Ricinus communis; Writhing