title: Expression pattern of Nogo-A, MAG, and NgR in regenerating urodele spinal cord.
abstract: BACKGROUND
  The mammalian central nervous system is incapable of substantial axon regeneration after injury partially due to the presence of myelin-associated inhibitory molecules including Nogo-A and myelin associated glycoprotein (MAG). In contrast, axolotl salamanders are capable of considerable axon regrowth during spinal cord regeneration.
  
  
  RESULTS
  Here, we show that Nogo-A and MAG, and their receptor, Nogo receptor (NgR), are present in the axolotl genome and are broadly expressed in the central nervous system (CNS) during development, adulthood, and importantly, during regeneration. Furthermore, we show that Nogo-A and NgR are co-expressed in Sox2 positive neural progenitor cells.
  
  
  CONCLUSIONS
  These expression patterns suggest myelin-associated proteins are permissive for neural development and regeneration in axolotls.
authors.affiliation: Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, Kolkata, India.
authors.forename: Subhra Prakash
authors.initials: SP
authors.lastname: Hui
authors.forename: James R
authors.initials: JR
authors.lastname: Monaghan
authors.forename: S Randal
authors.initials: SR
authors.lastname: Voss
authors.forename: Sukla
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000558:Ambystoma mexicanum / Q000378:metabolism*; D029845:Amphibian Proteins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D009185:Myelin Proteins / Q000235:genetics / Q000378:metabolism*; D018992:Myelin-Associated Glycoprotein / Q000235:genetics / Q000378:metabolism*; D000070798:Nogo Proteins; D013119:Spinal Cord Injuries / Q000235:genetics / Q000378:metabolism*; D058630:Spinal Cord Regeneration / Q000235:genetics / Q000502:physiology*
chemical_list: D029845:Amphibian Proteins; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D000070798:Nogo Proteins