title: Viral delivery of small-hairpin RNAs for reducing gene expression in the rodent brain.
abstract: This article reviews a strategy to ensure long-term expression of a type of interfering RNA molecule-small-hairpin RNAs (shRNAs)-through the use of viral delivery systems (i.e., vectors). Expression of these shRNAs leads to the destruction of the intermediary molecules (i.e., messenger RNA [mRNA] molecules) generated during the expression of the target gene.
authors.affiliation: Ernest Gallo Clinic and Research Center at the University of California at San Francisco, Emeryville, California.
authors.forename: Amy W
authors.initials: AW
authors.lastname: Lasek
authors.forename: Ulrike
authors.initials: U
authors.lastname: Heberlein
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D005786:Gene Expression Regulation; D018014:Gene Transfer Techniques; D006801:Humans; D016086:Lentivirus / Q000235:genetics*; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000235:genetics*
chemical_list: D034741:RNA, Small Interfering