title: Better early osteogenesis of electroconductive hydroxyapatite-calcium titanate composites in a rabbit animal model.
abstract: In view of the fact that bone healing can be enhanced due to external electric field application, it is important to assess the influence of the implant conductivity on the bone regeneration in vivo. To address this issue, this study reports the in vivo biocompatibility property of multistage spark plasma sintered hydroxyapatite (HA)-80 wt % calcium titanate (CaTiO3 ) composites and monolithic HA, which have widely different conductivity property (14 orders of magnitude difference). The ability of bone regeneration was assessed by implantation in cylindrical femoral bone defects of rabbit animal model for varying time period of 1, 4, and 12 weeks. The overall assessment of the histology results suggests that the progressive healing of bone defects around HA-80 wt % CaTiO3 is associated with a better efficacy with respect to (w.r.t) early stage neobone formation, which is histomorphometrically around 140% higher than monolithic HA. Overall, this study demonstrates that the in vivo biocompatibility property of HA-80 wt % CaTiO3 with respect to local effects after 12 weeks of implantation is not compromised both qualitatively and quantitatively, and a comparison with control implant (HA) points toward the critical role of electrical conductivity on better early stage bone regeneration.
authors.affiliation: Department of Materials Science and Engineering, Laboratory for Biomaterials, Indian Institute of Technology, Kanpur, 208016, Uttar Pradesh, India.
authors.forename: Prafulla Kumar
authors.initials: PK
authors.lastname: Mallik
authors.forename: Bikramjit
authors.initials: B
authors.lastname: Basu
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D002118:Calcium / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D004553:Electric Conductivity; D005260:Female; D005269:Femur / Q000293:injuries / Q000473:pathology / Q000502:physiology; D008297:Male; D023421:Models, Animal; D010012:Osteogenesis; D019736:Prostheses and Implants; D011817:Rabbits; D014025:Titanium / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D017886:Durapatite; D014025:Titanium; D002118:Calcium
keywords: HA; calcium titanate; electrical conductivity; in vivo biocompatibility