title: Subsequent shunt closure after targeted medical therapy can be an effective strategy for secundum atrial septal defect with severe pulmonary arterial hypertension: two case reports : strategy for ASD with severe PAH.
abstract: Secundum atrial septal defect (ASD) is the most common form of congenital heart disease in adults. Surgical and transcatheter closures of ASD are widely accepted therapeutic approaches. In patients with severe pulmonary arterial hypertension (PAH), however, the closure of the defect is still controversial. We report two cases of ASD patients with severe PAH successfully repaired subsequent to effective medical therapy. Subsequent shunt closure after targeted medical therapy can be an effective strategy in selected ASD patients with severe PAH.
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki Chuo, 650-0017, Kobe, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: Noriaki
authors.initials: N
authors.lastname: Emoto
authors.forename: Kazuya
authors.initials: K
authors.lastname: Miyagawa
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakayama
authors.forename: Hiroto
authors.initials: H
authors.lastname: Kinutani
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Tanaka
authors.forename: Toshiro
authors.initials: T
authors.lastname: Shinke
authors.forename: Kenji
authors.initials: K
authors.lastname: Okada
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Okita
authors.forename: Ken-ich
authors.initials: KI
authors.lastname: Hirata
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006328:Cardiac Catheterization; D004359:Drug Therapy, Combination; D065627:Familial Primary Pulmonary Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents