title: [Serum level of programmed cell death 5 protein levels in patients with sepsis].
abstract: OBJECTIVE
  To investigate the changes of serum programmed cell death 5 (PDCD5) levels in patients with critical illnesses including systemic inflammatory response syndrome (SIRS, except sepsis), sepsis (except severe sepsis) and severe sepsis.
  
  
  METHODS
  A total of 78 patients were enrolled in this study, of whom, 28 were with SIRS, 23 with sepsis and 27 with severe sepsis. Twenty-two healthy individuals were included as controls. The levels of serum PDCD5 were evaluated by enzyme-linked immune sorbent assay. And the correlation analyses were made in the levels of sreum PDCD5 and acute physiology and chronic health evaluation II(APACHE II), high-sensitivity C-reactive protein(hs-CRP), white blood cell count, neutrophil count and age factors.
  
  
  RESULTS
  Serum PDCD5 levels in the SIRS, sepsis and severe sepsis groups were (19.07 ± 8.91), (29.03 ± 13.27) and (42.83 ± 17.32) μg/L respectively, which were significantly higher than that in the healthy control group (0.32 ± 0.02) μg/L. Serum PDCD5 levels in SIRS, sepsis and severe sepsis groups were gradually increased with significant difference at any in-between comparison (P<0.05). Moreover, serum PDCD5 levels were positively correlated with the acute physiology and chronic health evaluation II (APACHE II) score (r=0.572, P<0.05).
  
  
  CONCLUSIONS
  The serum PDCD5 levels in the critically ill patients with sepsis were progressively increased with the worsened condition. The up-regulated expression of PDCD5 may play an important role in the development and progression of sepsis.
authors.affiliation: Departments of Emergency, Peking University Third Hospital, Beijing 100091, China.
authors.forename: Hui-lin
authors.initials: HL
authors.lastname: Liu
authors.forename: Qing
authors.initials: Q
authors.lastname: Tian
authors.forename: Tian-pei
authors.initials: TP
authors.lastname: Hong
authors.forename: Gui-hua
authors.initials: GH
authors.lastname: Liu
authors.forename: Huan
authors.initials: H
authors.lastname: Pan
authors.forename: Hai-ning
authors.initials: HN
authors.lastname: Wang
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Gao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D051017:Apoptosis Regulatory Proteins / Q000097:blood*; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D018805:Sepsis / Q000097:blood*; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood*; D015854:Up-Regulation
chemical_list: D051017:Apoptosis Regulatory Proteins; D009363:Neoplasm Proteins; C117283:PDCD5 protein, human