title: A critical literature review of health economic evaluations of rotavirus vaccination.
abstract: Two licensed vaccines are available to prevent RVGE in infants. A worldwide critical review of economic evaluations of these vaccines was conducted. The objective was to describe differences in methodologies, assumptions and inputs and determine the key factors driving differences in conclusions. 68 economic evaluations were reviewed. RV vaccination was found to be cost-effective in developing countries, while conclusions varied between studies in developed countries. Many studies found that vaccination was likely to be cost-effective under some scenarios, such as lower prices scenarios, inclusion of herd protection, and/or adoption of a societal perspective. Other reasons for variability included uncertainty around healthcare visits incidence and lack of consensus on quality of life (QoL) valuation for infants and caregivers. New evidence on the vaccination effectiveness in real-world, new ways of modeling herd protection and assessments of QoL in children could help more precisely define the conditions under which RV vaccination would be cost-effective in developed countries.
authors.affiliation: Creativ-Ceutical; Paris, France.
authors.forename: Samuel
authors.initials: S
authors.lastname: Aballéa
authors.forename: Aurélie
authors.initials: A
authors.lastname: Millier
authors.forename: Sibilia
authors.initials: S
authors.lastname: Quilici
authors.forename: Stuart
authors.initials: S
authors.lastname: Caroll
authors.forename: Stavros
authors.initials: S
authors.lastname: Petrou
authors.forename: Mondher
authors.initials: M
authors.lastname: Toumi
mesh_terms: D003362:Cost-Benefit Analysis; D019049:Developed Countries; D003906:Developing Countries; D005759:Gastroenteritis / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control; D014943:Global Health; D006801:Humans; D012400:Rotavirus Infections / Q000191:economics* / Q000453:epidemiology* / Q000517:prevention & control; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000191:economics* / Q000276:immunology*; D014611:Vaccination / Q000191:economics* / Q000379:methods*
chemical_list: D022243:Rotavirus Vaccines
keywords: cost-effectiveness; economic evaluations; economic model; pediatrics; review; rotavirus; vaccination