title: Regulation of chromatin structure in the cardiovascular system.
abstract: It has been appreciated for some time that cardiovascular disease involves large-scale transcriptional changes in various cell types. What has become increasingly clear only in the past few years, however, is the role of chromatin remodeling in cardiovascular phenotypes in normal physiology, as well as in development and disease. This review summarizes the state of the chromatin field in terms of distinct mechanisms to regulate chromatin structure in vivo, identifying when these modes of regulation have been demonstrated in cardiovascular tissues. We describe areas in which a better understanding of chromatin structure is leading to new insights into the fundamental biology of cardiovascular disease.
authors.affiliation: Department of Anesthesiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
authors.forename: Manuel
authors.initials: M
authors.lastname: Rosa-Garrido
authors.forename: Elaheh
authors.initials: E
authors.lastname: Karbassi
authors.forename: Emma
authors.initials: E
authors.lastname: Monte
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Vondriska
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology; D002319:Cardiovascular System / Q000378:metabolism / Q000473:pathology; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D006801:Humans
chemical_list: D002843:Chromatin