title: [A case report of Streptococcus pneumoniae-induced hemolytic uremic syndrome: appropriate transfusional management by T-antigen determination].
abstract: Pediatric hemolytic uremic syndrome (HUS) is a rare complication of infections usually caused by Escherichia coli; Streptococcus pneumoniae may be a causative agent in 5% of cases and is often more serious in terms of morbidity and mortality. We report a case of pediatric HUS following an infection by a serotype of S. pneumoniae not included in the vaccine administered to the child. Bacterial neuraminidase revealed a T-antigen and a Tk-antigen and red blood cells polyagglutinability in the laboratory test. Transfusion has been reoriented by an indication of secondary preparations: deplasmatisation of red blood cells and platelets and abstention of therapeutic plasma administration. HUS evolved favorably in a few days but the child retains consequences of meningitis cerebral anoxia.
authors.affiliation: Laboratoire d'immunologie, CHU Saint-Etienne, France. melanie.rinaudo@gmail.com
authors.forename: Mélanie
authors.initials: M
authors.lastname: Rinaudo-Gaujous
authors.forename: Emilie
authors.initials: E
authors.lastname: Talagrand
authors.forename: Paul O
authors.initials: PO
authors.lastname: Verhoeven
authors.forename: Olivier
authors.initials: O
authors.lastname: Garraud
authors.forename: Françoise
authors.initials: F
authors.lastname: Flourié
mesh_terms: D000957:Antigens, Viral, Tumor / Q000032:analysis*; D001803:Blood Transfusion; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology* / Q000628:therapy*; D006801:Humans; D007223:Infant; D008586:Meningitis, Pneumococcal / Q000134:cerebrospinal fluid / Q000150:complications / Q000209:etiology / Q000628:therapy; D010530:Peritoneal Dialysis; D011008:Pneumococcal Infections / Q000150:complications*; D012698:Serologic Tests; D013296:Streptococcus pneumoniae / Q000302:isolation & purification*
chemical_list: D000957:Antigens, Viral, Tumor
keywords: Streptococcus pneumonia; hemolytic and uremic syndrome; polyagglutinability