title: Characteristics improvement of calcium hydroxide dental cement by hydroxyapatite nanoparticles. Part 1: formulation and microstructure.
abstract: Calcium hydroxide cement (CHC), which is a direct pulp-capping material, has been widely used for several decades. In spite of the well-known advantages of CHCs, they have some disadvantages as well, such as high solubility, no inherent adhesive qualities, and low mechanical strength. Previous studies were undertaken to improve these deficiencies by implementing changes to modify the conventional CHCs. The aim of the present research is to demonstrate the potential rectification of the aforementioned deficiencies of the commercially available CHCs by adding hydroxyapatite (HA) nanoparticles without lessening their advantages. Here, the synthesized HA nanoparticles were added into the CHCs in two different portions of 3 and 7 wt%. A scanning electron microscope was used to observe and analyze the microstructure, and X-ray energy dispersive analysis was used to analyze the elemental composition of the new CHCs. In addition, setting time, mechanical strength, pH, calcium (Ca) release, and antibacterial behavior were measured to assess how HA nanoparticles influence the characteristics of CHCs. The results showed that adding 3 wt% HA nanoparticles can optimally improve the mechanical strength of the cement and increase the Ca release rate as a mineralization promoter without reducing the antibacterial behavior.
authors.affiliation: Biomaterials Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, Tehran, Iran.
authors.forename: Mana
authors.initials: M
authors.lastname: Yasaei
authors.forename: Ali
authors.initials: A
authors.lastname: Zamanian
authors.forename: Fathollah
authors.initials: F
authors.lastname: Moztarzadeh
authors.forename: Maryam
authors.initials: M
authors.lastname: Ghaffari
authors.forename: Masoud
authors.initials: M
authors.lastname: Mozafari
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002118:Calcium / Q000737:chemistry / Q000378:metabolism; D002126:Calcium Hydroxide / Q000737:chemistry*; D003738:Dental Cements / Q000737:chemistry*; D017886:Durapatite / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013295:Streptococcus mutans / Q000187:drug effects; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D003738:Dental Cements; D017886:Durapatite; D002126:Calcium Hydroxide; D002118:Calcium
keywords: antibacterial properties; calcium hydroxide cement; hydroxyapatite; ionic release; nanoparticle