title: Aberrant lipid metabolism: an emerging diagnostic and therapeutic target in ovarian cancer.
abstract: Ovarian cancer remains the most lethal gynaecological cancer. A better understanding of the molecular pathogenesis of ovarian cancer is of critical importance to develop early detection tests and identify new therapeutic targets that would increase survival. Cancer cells depend on de novo lipid synthesis for the generation of fatty acids to meet the energy requirements for increased tumour growth. There is increasing evidence that lipid metabolism is deregulated in cancers, including ovarian cancer. The increased expression and activity of lipogenic enzymes is largely responsible for increased lipid synthesis, which is regulated by metabolic and oncogenic signalling pathways. This article reviews the latest knowledge on lipid metabolism and the alterations in the expression of lipogenic enzymes and downstream signalling pathways in ovarian cancer. Current developments for exploiting lipids as biomarkers for the detection of early stage ovarian cancer and therapeutic targets are discussed. Current research targeting lipogenic enzymes and lipids to increase the cytotoxicity of chemotherapy drugs is also highlighted.
authors.affiliation: Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Research Centre for Reproductive Health, Robinson Institute, University of Adelaide, Adelaide 5005, Australia. martin.oehler@adelaide.edu.au.
authors.forename: Carmen E
authors.initials: CE
authors.lastname: Pyragius
authors.forename: Maria
authors.initials: M
authors.lastname: Fuller
authors.forename: Carmela
authors.initials: C
authors.lastname: Ricciardelli
authors.forename: Martin K
authors.initials: MK
authors.lastname: Oehler
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D004734:Energy Metabolism; D005227:Fatty Acids / Q000096:biosynthesis; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D015398:Signal Transduction
chemical_list: D014408:Biomarkers, Tumor; D005227:Fatty Acids