title: Clinical and virological characteristics of chronic hepatitis B patients with hepatic steatosis.
abstract: OBJECTIVE
  This study aimed to explore clinical and virological characteristics of chronic hepatitis B (CHB) patients with hepatic steatosis in order to provide a theoretical basis for the prevention and control of hepatic steatosis.
  
  
  METHODS
  A total of 360 CHB inpatients were recruited from Affiliated Dongnan Hospital of Xiamen University and divided into hepatic steatosis group and non-hepatic steatosis group. The body mass index (BMI), waist-to-hip ratio (WHR), fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), hepatitis B e antigen (HBeAg), hepatitis B virus DNA (HBV DNA) and hepatic histological changes were detected and compared between the two groups. The association of these factors with hepatic steatosis was evaluated in CHB patients.
  
  
  RESULTS
  BMI, FPG, TG, TC, GGT, AST and HBV DNA showed statistically significant differences between two groups (P<0.01). The patients with hepatic steatosis had markedly higher BMI, FBG, TG and TC than those without steatosis did. No significant differences were found in ALT and HBeAg between two groups (P>0.05). In male patients, there was marked difference in the WHR between two groups (P < 0.01), which was not found in female patients (P > 0.05). The severity of hepatic steatosis increased in patients with hepatic steatosis, compared to those without steatosis (P < 0.01), but the severities of inflammation and fibrosis in the non-hepatic steatosis group were dramatically higher than those in the hepatic steatosis group (P < 0.01).
  
  
  CONCLUSIONS
  BMI, WHR, FBG, TG and TC appeared to be influencing factors of CHB combined with hepatic steatosis. Hepatic steatosis in CHB patients was closely related to changes in anthropometric indices and metabolic factors but not HBV. It is necessary to improve these factors to effectively prevent hepatic steatosis in CHB patients.
authors.affiliation: Research and Therapy Center for Liver Disease, the Affiliated Dongnan Hospital of Xiamen University, Zhangzhou 363000, Fujian, China.
authors.forename: Rui-dan
authors.initials: RD
authors.lastname: Zheng
authors.forename: Jian-neng
authors.initials: JN
authors.lastname: Chen
authors.forename: Qun-ying
authors.initials: QY
authors.lastname: Zhuang
authors.forename: Yan-hui
authors.initials: YH
authors.lastname: Lu
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Bi-fen
authors.initials: BF
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001786:Blood Glucose; D015992:Body Mass Index; D002648:Child; D002784:Cholesterol / Q000097:blood; D005215:Fasting; D005234:Fatty Liver / Q000097:blood / Q000150:complications / Q000473:pathology* / Q000821:virology; D005260:Female; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000302:isolation & purification / Q000472:pathogenicity; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications / Q000473:pathology* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D001786:Blood Glucose; D006513:Hepatitis B e Antigens; D014280:Triglycerides; D002784:Cholesterol; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase
keywords: Chronic hepatitis B; Hepatic steatosis; Metabolic factor.; anthropometric index