title: [Effects of dietary different ratios of high n - 3/n - 6 polyunsaturated fatty acids on insulin resistance in rats].
abstract: OBJECTIVE
  To study the effects of dietary different ratios of high-fat n - 3/ n - 6 polyunsaturated fatty acids (PUFAs) on insulin sensitivity and pro-inflammatory cytokines expression in serum of rats.
  
  
  METHODS
  40 young male SD rats (n = 10) after adaptive feeding 7d were randomly divided into 4 groups, fed by common diet, high fat diet, high fat with n - 3/n - 6 1 : 1 PUFAs diet, and high fat with n - 3/n - 6 1 : 4 PUFAs diet. The animals were weighted weekly and sacrificed at 16 weeks, then blood lipids, serum insulin sensitivity and pro-inflammatory cytokines (IL-6, TNF-alpha and hs-CRP) were determined.
  
  
  RESULTS
  Compared with normal control group, three high fat groups result in a significant increase of body weight gain. Insulin sensitivity of high fat 1 : 1 group had no significant difference with normal control, but is significantly higher than high-fat and high-fat 1 : 4 group (P < 0.05). Compared with high fat group, pro-inflammatory cytokines expression of high fat 1 : 1 group decreased significantly (P < 0.05).
  
  
  CONCLUSIONS
  High dietary polyunsaturated fatty acids appears associated with a trend towards obesity risk, however, increase of the proportion of n - 3 PUFAs dietary composition effectively decreased the expression of pro-inflammatory cytokines, then, improved insulin sensitivity and prevented insulin resistance.
authors.affiliation: Department of Nutrition and Food Hygiene, Fourth Military Medical University, Xi'an 710032, China. qiuya720@163.com
authors.forename: Ya
authors.initials: Y
authors.lastname: Qiu
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Hanqiang
authors.initials: H
authors.lastname: Liu
authors.forename: Ruihua
authors.initials: R
authors.lastname: Yang
authors.forename: Xiaona
authors.initials: X
authors.lastname: Xu
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
mesh_terms: D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000032:analysis; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage* / Q000032:analysis; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000209:etiology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6