title: Clinical outcomes of radiation-based locoregional therapy in locally advanced head and neck squamous cell carcinoma patients not responding to induction chemotherapy.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the efficacy of radiation-based locoregional therapy for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) patients who did not respond to induction chemotherapy (IC).
  
  
  METHODS
  Outcomes after radiation-based locoregional therapy were retrospectively analyzed.
  
  
  RESULTS
  Among a total of 208 patients treated with IC, 46 (22.1%) did not respond. After IC, patients were treated with radiotherapy (RT), concurrent chemoradiotherapy (CCRT), or surgery with or without postoperative RT. Among the 46 nonresponders, 17 (37.8%) patients underwent surgery and 28 (62.2%) were treated with RT or CCRT. Responses to subsequent RT or CCRT for 26 evaluable patients were as follows: complete response=7 (26.9%), partial response=9 (34.6%), stable disease=4 (15.4%), and progressive disease=6 (23.1%).
  
  
  CONCLUSIONS
  A significant proportion of LA-HNSCC patients who did not respond to IC can benefit from subsequent RT or CCRT.
authors.affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Yoojoo
authors.initials: Y
authors.lastname: Lim
authors.forename: Bhumsuk
authors.initials: B
authors.lastname: Keam
authors.forename: Youngil
authors.initials: Y
authors.lastname: Koh
authors.forename: Tae Min
authors.initials: TM
authors.lastname: Kim
authors.forename: Se-Hoon
authors.initials: SH
authors.lastname: Lee
authors.forename: J Hun
authors.initials: JH
authors.lastname: Hah
authors.forename: Tack-Kyun
authors.initials: TK
authors.lastname: Kwon
authors.forename: Dong-Wan
authors.initials: DW
authors.lastname: Kim
authors.forename: Hong-Gyun
authors.initials: HG
authors.lastname: Wu
authors.forename: Myung-Whun
authors.initials: MW
authors.lastname: Sung
authors.forename: Dae Seog
authors.initials: DS
authors.lastname: Heo
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D060828:Induction Chemotherapy; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome