title: Theoretical model for cell migration with gradient sensing and shape deformation.
abstract: Amoeboid cells take various shapes during migration, depending on the cell type and its environment. Deformability of the cell shape can then affect the migrating behavior. In this article, we introduce a theoretical model of chemotactic cell migration with elliptical shape deformation. Based on the model, we calculate the stationary distributions of the migration directions analytically. As a result, we find that the distributions show different characteristics depending on the difference in the interdependence of the internal polarity, cell morphology and gradient sensing.
authors.affiliation: Center for Developmental Biology, RIKEN, Chuo-ku, Kobe 565-0871, Hyogo, Japan. tetsuhiraiwa@gmail.com
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hiraiwa
authors.forename: Akinori
authors.initials: A
authors.lastname: Baba
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Shibata
mesh_terms: D048430:Cell Shape; D002633:Chemotaxis; D004058:Diffusion; D008954:Models, Biological