title: [Biomarkers of systemic inflammation, oxidative stress and their interactions in patients with combined flow of chronic obstructive pulmonary disease and arterial hypertension].
abstract: A total of 98 patients with chronic obstructive pulmonary disease, arterial hypertension and combined flow of both chronic obstructive pulmonary disease and arterial hypertension were examined. The patients were divided into 3 groups. The first group included patients with arterial hypertension, the second consisted of patients with COPD, the third of patients with combined flow of COPD and AH. ELISA method was used to determine serum concentrations of interleukin-6 and tumor necrosis factor-α. Immunoturbidimetric method was used to measure the concentration of C-reactive protein. Spectrophotometrically markers of oxidative stress, the levels of oxidative protein modifications were measured. It was found that there was a significant increase in levels of interleukin-6, tumor necrosis factor-α and C-reactive protein in patients with combined flow of chronic obstructive pulmonary disease and arterial hypertension while comparing with other groups. In patients with comorbid disorders COPD and AH an increase in products of oxidative modification of proteins, spontaneous and iron induced aldehydephenylhydrazone's and ketondinitrophenylhydrazone's were also observed. Significant correlations between biomarkers of systemic inflammation and oxidative stress were found.
authors.affiliation: Zaporizhia State Medical University, Zaporizhia, Ukraine.
authors.forename: V
authors.initials: V
authors.lastname: Kryvenko
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism; D007249:Inflammation / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011014:Pneumonia / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; D011506:Proteins; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein