title: Regulation of PCNA-protein interactions for genome stability.
abstract: Proliferating cell nuclear antigen (PCNA) has a central role in promoting faithful DNA replication, providing a molecular platform that facilitates the myriad protein-protein and protein-DNA interactions that occur at the replication fork. Numerous PCNA-associated proteins compete for binding to a common surface on PCNA; hence these interactions need to be tightly regulated and coordinated to ensure proper chromosome replication and integrity. Control of PCNA-protein interactions is multilayered and involves post-translational modifications, in particular ubiquitylation, accessory factors and regulated degradation of PCNA-associated proteins. This regulatory framework allows cells to maintain a fine-tuned balance between replication fidelity and processivity in response to DNA damage.
authors.affiliation: Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark. niels.mailand@cpr.ku.dk
authors.forename: Niels
authors.initials: N
authors.lastname: Mailand
authors.forename: Ian
authors.initials: I
authors.lastname: Gibbs-Seymour
authors.forename: Simon
authors.initials: S
authors.lastname: Bekker-Jensen
mesh_terms: D004249:DNA Damage; D004261:DNA Replication; D042822:Genomic Instability; D006801:Humans; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics* / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D018809:Proliferating Cell Nuclear Antigen