title: Management of pregnancies with confirmed cytomegalovirus fetal infection.
abstract: Systematic screening for cytomegalovirus (CMV) maternal infection is not recommended in most countries. Nevertheless, primary CMV infection will occur in around 1% of women. The vertical transmission rate is estimated to be around 30-50%. Newborns with congenital CMV infection remain asymptomatic in the majority of cases and around 10% will present with a wide range of abnormalities. Fetal infection can be diagnosed by amniocentesis with amplification of the viral genome in the amniotic fluid by polymerase chain reaction. This prenatal diagnosis is mainly performed when ultrasound abnormalities are observed. The purpose of this mini-review is to describe the management options when a fetus is known to be infected.
authors.affiliation: Department of Obstetrics and Maternal-Fetal Medicine, GHU Necker-Enfants Malades, AP-HP, Université Paris Descartes, Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Benoist
authors.forename: Marianne
authors.initials: M
authors.lastname: Leruez-Ville
authors.forename: Jean François
authors.initials: JF
authors.lastname: Magny
authors.forename: François
authors.initials: F
authors.lastname: Jacquemard
authors.forename: Laurent J
authors.initials: LJ
authors.lastname: Salomon
authors.forename: Yves
authors.initials: Y
authors.lastname: Ville
mesh_terms: D000212:Acyclovir / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000821:virology; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000151:congenital / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D003663:Decision Trees; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy* / Q000821:virology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D012720:Severity of Illness Index; D014463:Ultrasonography; D000077483:Valacyclovir; D014633:Valine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir