title: Microarray analysis of microRNA expression in liver cancer tissues and normal control.
abstract: BACKGROUND
  Recently, many studies have focused on microRNAs (miRNAs) expression profiling in liver cancer, due to the ability of these small RNAs to potently influence cellular behavior. In this study, to further investigate the relationship between them, the miRNA expression profiling of the cancer liver tissues and normal liver tissues were compared.
  
  
  METHODS
  The datasets of miRNAs microarray in liver cancer and normal control were downloaded from Gene Expression Omnibus. Then the SOAP analysis was performed to identify the differentially expressed miRNAs.
  
  
  RESULTS
  A total of 221 differentially expressed miRNAs were found. Five of them (including hsa-miR-15b, hsa-miR-1975, hsa-miR-199a-3p, hsa-miR-199b-3p and hsa-miR-421) were determined by t-test and may be involved in the pathogenesis of liver cancer.
  
  
  CONCLUSIONS
  There differentially expressed miRNAs may be potential molecular markers for liver cancer screening.
authors.affiliation: Department of Gastroenterology and Hepatology, Shengjing Hospital of China Medical University, 36 Sanhao, Heping, Shenyang 110004, China. audreylin73@hotmail.com
authors.forename: Lianjie
authors.initials: L
authors.lastname: Lin
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.forename: Yu
authors.initials: Y
authors.lastname: Jin
authors.forename: Changqing
authors.initials: C
authors.lastname: Zheng
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002874:Chromosome Mapping; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D035683:MicroRNAs