title: Abdominal wall healing in incisional hernia using different biomaterials in rabbits.
abstract: OBJECTIVE
  To investigate abdominal wound healing using specific biomaterials in incisional hernias.
  
  
  METHODS
  Incisional hernias were produced in 40 rabbits, after that they were reoperated with or without the use of meshes: PREMILENE® (PPL), ULTRAPRO® (UP), PROCEED® (PCD) or repairing without mesh (TRANSPALB). After 30 days a macroscopic and microscopic study of the part withdrawn from the abdominal wall was performed.
  
  
  RESULTS
  Macroscopic: adhesion Area: PPL> UP and PCD (p = 0.031). Vascularization: PPL> UP and PCD (p = 0.001). PPL groups (p = 0.032) and PCD (p <0.001) showed greater meshes shrinkages when compared to UP. Microscopic: neutrophils: PCD> PPL, UP and TRANSPALB (p = 0.010); eosinophils: PPL> UP, and TRANSPALB PCD (p = 0.010); granulation tissue: PPL and PCD> UP and TRANSPALB (p <0.001); macrophages : PPL, UP and PCD> TRANSPALB (p <0.001); lymphocytes: PPL and PCD> UP (p = 0.009) and TRANSPALB (p <0.001); giant cells: PPL, UP and PCD> TRANSPALB (p <0.001); viscera adhered: PPL and UP> PCD and TRANSPALB (p <0.001).
  
  
  CONCLUSIONS
  All types of meshes caused the formation of adhesions. The UP and PCD groups showed lower area and vascularization of the adhesions. The PPL and PCD groups showed higher meshes shrinkage and there was a predominance of acute inflammatory process in the PCD group.
authors.affiliation: Postgraduate Program in Interdisciplinary Surgical Sciences, Paulista Medical School, UNIFESP, Sao Paulo, SP, Brazil.
authors.forename: Ana Letícia Gomes
authors.initials: AL
authors.lastname: Aramayo
authors.forename: Gaspar de Jesus
authors.initials: Gde J
authors.lastname: Lopes Filho
authors.forename: Cirênio de Almeida
authors.initials: Cde A
authors.lastname: Barbosa
authors.forename: Vânia da Fonseca
authors.initials: Vda F
authors.lastname: Amaral
authors.forename: Luciano Assis
authors.initials: LA
authors.lastname: Costa
mesh_terms: D034861:Abdominal Wall / Q000473:pathology / Q000601:surgery*; D000818:Animals; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use*; D046449:Hernia, Abdominal / Q000601:surgery*; D008297:Male; D008422:Materials Testing; D011126:Polypropylenes / Q000627:therapeutic use; D011817:Rabbits; D015203:Reproducibility of Results; D013526:Surgical Mesh; D013997:Time Factors; D000267:Tissue Adhesions; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D020099:Coated Materials, Biocompatible; D011126:Polypropylenes