title: Targeting deregulated epigenetic control in cancer.
abstract: Cancer is a multifaceted disease that involves acquisition of genetic mutations, deletions, and amplifications as well as deregulation of epigenetic mechanisms that fine-tune gene regulation. Key epigenetic mechanisms that include histone modifications, DNA methylation, and non-coding RNA-mediated gene silencing are often deregulated in a variety of cancers. Subnuclear localization of key proteins in the interphase nucleus and bookmarking of genes by lineage commitment factors in mitosis-a new dimension to epigenetic control of fundamental biological processes-is also modified in cancer. In this review, we discuss the various aspects of epigenetic control that are operative in a variety of cancers and their potential for risk assessment, early detection, targeted therapy, and personalized medicine.
authors.affiliation: Department of Biochemistry, University of Vermont, Burlington, Vermont, USA.
authors.forename: Sayyed K
authors.initials: SK
authors.lastname: Zaidi
authors.forename: Andre J
authors.initials: AJ
authors.lastname: Van Wijnen
authors.forename: Jane B
authors.initials: JB
authors.lastname: Lian
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stein
authors.forename: Gary S
authors.initials: GS
authors.lastname: Stein
mesh_terms: D000818:Animals; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic; D006657:Histones / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D022661:RNA, Untranslated / Q000378:metabolism; D057170:Translational Research, Biomedical
chemical_list: D006657:Histones; D022661:RNA, Untranslated