title: Lung cancer complicated with IgG4-related disease of the lung.
abstract: Few have reported a concomitant malignant neoplasm with immunoglobulin G4 (IgG4)-related diseases. We describe a case of lung cancer and gastric cancer accompanied with IgG4-related disease. A 78-year-old man had an area of ground-glass opacity with central collapse in right upper lobe and a gastric cancer. The patient underwent a right upper lobectomy following a gastrectomy for the gastric cancer. Histological examination of the resected lung specimen revealed a lepidic pattern of an adenocarcinoma and a large amount of plasmacyte infiltration around the tumor. In immunohistochemical findings, the plasmacytes were stained for IgG4. Therefore, the lung tumor was considered to have associated with IgG4-related interstitial lesions.
authors.affiliation: Department of General Thoracic Surgery, Dokkyo Medical University.
authors.forename: Takashi
authors.initials: T
authors.lastname: Inoue
authors.forename: Makio
authors.initials: M
authors.lastname: Hayama
authors.forename: Satoru
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Oyaizu
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Nakazato
authors.forename: Koichi
authors.initials: K
authors.lastname: Honma
authors.forename: Masayuki
authors.initials: M
authors.lastname: Chida
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000601:surgery; D000368:Aged; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007150:Immunohistochemistry; D008171:Lung Diseases / Q000150:complications*; D008175:Lung Neoplasms / Q000150:complications* / Q000601:surgery; D008297:Male; D010950:Plasma Cells / Q000276:immunology; D013274:Stomach Neoplasms / Q000150:complications / Q000601:surgery
chemical_list: D007074:Immunoglobulin G