title: How to get out: ssRNA enveloped viruses and membrane fission.
abstract: Enveloped viruses acquire their membrane from the host cell and accordingly need to separate their envelope from cellular membranes via membrane fission. Although some of the enveloped viruses recruit the endosomal sorting complex required for transport (ESCRT) to catalyze the final fission reaction, many enveloped viruses seem to bud in an ESCRT-independent manner. Here we describe the principles that govern membrane fission reactions in general and review progress in the understanding of ESCRT-mediated membrane fission. We relate ESCRT function to budding of single stranded RNA viruses and discuss alternative ways to mediate membrane fission that may govern ESCRT-independent budding.
authors.affiliation: Unit of Virus Host Cell Interactions (UVHCI), UMI 3265, Université Joseph Fourier-EMBL-CNRS, 6 rue Jules Horowitz, 38042 Grenoble Cedex 9, France. weissenhorn@embl.fr
authors.forename: Winfried
authors.initials: W
authors.lastname: Weissenhorn
authors.forename: Emilie
authors.initials: E
authors.lastname: Poudevigne
authors.forename: Gregory
authors.initials: G
authors.lastname: Effantin
authors.forename: Patricia
authors.initials: P
authors.lastname: Bassereau
mesh_terms: D002462:Cell Membrane / Q000378:metabolism* / Q000821:virology*; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism; D012328:RNA Viruses / Q000502:physiology*; D057074:Virus Release
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport