title: EANM Dosimetry Committee series on standard operational procedures for pre-therapeutic dosimetry II. Dosimetry prior to radioiodine therapy of benign thyroid diseases.
abstract: The EANM Dosimetry Committee Series "Standard Operational Procedures for Pre-Therapeutic Dosimetry" (SOP) provides advice to scientists and clinicians on how to perform patient-specific absorbed dose assessments. This particular SOP describes how to tailor the therapeutic activity to be administered for radioiodine therapy of benign thyroid diseases such as Graves' disease or hyperthyroidism. Pretherapeutic dosimetry is based on the assessment of the individual (131)I kinetics in the target tissue after the administration of a tracer activity. The present SOP makes proposals on the equipment to be used and guides the user through the measurements. Time schedules for the measurement of the fractional (131)I uptake in the diseased tissue are recommended and it is shown how to calculate from these datasets the therapeutic activity necessary to administer a predefined target dose in the subsequent therapy. Potential sources of error are pointed out and the inherent uncertainties of the procedures depending on the number of measurements are discussed. The theoretical background and the derivation of the listed equations from compartment models of the iodine kinetics are explained in a supplementary file published online only.
authors.affiliation: Department of Nuclear Medicine, University of Würzburg, Oberdürrbacher Str. 6, 97080 Würzburg, Germany.
authors.forename: Heribert
authors.initials: H
authors.lastname: Hänscheid
authors.forename: Cristina
authors.initials: C
authors.lastname: Canzi
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Eschner
authors.forename: Glenn
authors.initials: G
authors.lastname: Flux
authors.forename: Markus
authors.initials: M
authors.lastname: Luster
authors.forename: Lidia
authors.initials: L
authors.lastname: Strigari
authors.forename: Michael
authors.initials: M
authors.lastname: Lassmann
mesh_terms: D001692:Biological Transport; D005060:Europe; D015902:Gamma Cameras; D006801:Humans; D007457:Iodine Radioisotopes / Q000378:metabolism / Q000627:therapeutic use; D009683:Nuclear Medicine / Q000295:instrumentation / Q000592:standards*; D019047:Phantoms, Imaging; D011786:Quality Control; D011835:Radiation Protection; D011874:Radiometry / Q000295:instrumentation / Q000592:standards*; D019275:Radiopharmaceuticals / Q000378:metabolism / Q000627:therapeutic use; D012015:Reference Standards; D012107:Research Design; D012955:Societies, Medical / Q000592:standards*; D013959:Thyroid Diseases / Q000532:radiotherapy*
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals