title: Noncatalytic pyridyl-directed alkylation and arylation carbon-fluorine bond of polyfluoroarenes with Grignard reagents.
abstract: Cross-coupling reaction of polyfluoroarenes with Grignard reagents via pyridine-directed cleavage of C-F bond in the absence of metal catalysts was developed. A possible mechanism was suggested.
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiong
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wu
authors.forename: Senhan
authors.initials: S
authors.lastname: Xiao
authors.forename: Juan
authors.initials: J
authors.lastname: Xiao
authors.forename: Song
authors.initials: S
authors.lastname: Cao
mesh_terms: D000478:Alkylation; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D005461:Fluorine / Q000737:chemistry*; D005464:Fluorobenzenes / Q000138:chemical synthesis* / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005464:Fluorobenzenes; D009942:Organometallic Compounds; D011725:Pyridines; D005461:Fluorine; D002244:Carbon