title: Antihyperglycemic effect of Hypericum perforatum ethyl acetate extract on streptozotocin-induced diabetic rats.
abstract: OBJECTIVE
  To evaluate the antihyperglycemic activity of ethyl acetate extract of Hypericum perforatum (H. perforatum) in streptozotocin (STZ)-induced diabetic rats.
  
  
  METHODS
  Acute toxicity and oral glucose tolerance test were performed in normal rats. Male albino rats were rendered diabetic by STZ (40 mg/kg, intraperitoneally). H. perforatum ethyl acetate extract was orally administered to diabetic rats at 50, 100 and 200 mg/kg doses for 15 days to determine the antihyperglycemic activity. Biochemical parameters were determined at the end of the treatment.
  
  
  RESULTS
  H. perforatum ethyl acetate extract showed dose dependant fall in fasting blood glucose (FBG). After 30 min of extract administration, FBG was reduced significantly when compared with normal rats. H. perforatum ethyl acetate extract produced significant reduction in plasma glucose level, serum total cholesterol, triglycerides, glucose-6-phosphatase levels. Tissue glycogen content, HDL-cholesterol, glucose-6-phosphate dehydrogenase were significantly increased compared with diabetic control. No death or lethal effect was observed in the toxic study.
  
  
  CONCLUSIONS
  The results demonstrate that H. perforatum ethyl acetate extract possesses potent antihyperglycemic activity in STZ induced diabetic rats.
authors.affiliation: Department of PG and Research, Sathyabama University, Chennai-119, India.
authors.forename: S
authors.initials: S
authors.lastname: Arokiyaraj
authors.forename: R
authors.initials: R
authors.lastname: Balamurugan
authors.forename: P
authors.initials: P
authors.lastname: Augustian
mesh_terms: D000085:Acetates; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D020902:Hypericum / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000085:Acetates; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D010936:Plant Extracts; C007650:ethyl acetate
keywords: Antidiabetic; Antihyperglycemic effect; Carbohydrate metabolism enzymes; Fasting blood glucose; Hypericum perforatum; Plasma insulin; Streptozitocin