title: Transient Mesp1 expression: a driver of cardiac cell fate determination.
abstract: Mesp1 sits on the tip of the cardiac regulatory hierarchy, recent evidences support that it is regulated by stem cell factor Oct4, early gastrulation signal canonical Wnts and a couple of T-box factors, T and Eomes. With other transcription factors, Mesp1 programs/reprograms human cells toward cardiomyocytes.
authors.affiliation: Department of Biology and Biochemistry; University of Houston; Houston, TX USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Schwartz
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation; D065150:Cellular Reprogramming; D053595:Embryonic Stem Cells / Q000166:cytology; D006801:Humans; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000378:metabolism; D050814:Octamer Transcription Factor-3 / Q000378:metabolism; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D050787:Proto-Oncogene Protein c-ets-2 / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D050814:Octamer Transcription Factor-3; D050787:Proto-Oncogene Protein c-ets-2; D051153:Wnt Proteins; C494069:ETS2 protein, human; C000589015:MESP1 protein, human; C494173:POU5F1 protein, human
keywords: Mesp1; embryonic stem cells; progenitor cells; reprograming; transcription factor