title: Chondrosarcoma arising within a radiation-induced osteochondroma several years following childhood total body irradiation: case report.
abstract: Malignant degeneration arising in radiation-induced osteochondromas is extremely rare. We report a case of a 34-year-old man with a chondrosarcoma arising from an osteochondroma of the left posterior eighth rib that developed following total body irradiation received as part of the conditioning regimen prior to bone marrow transplantation at age 8. To our knowledge, this is only the fourth reported case of a chondrosarcoma arising within a radiation-induced osteochondroma and the first case occurring following childhood total body irradiation.
authors.affiliation: Department of radiology, Kurume University Hospital, Fukuoka, Japan. sn4735@med.kurume-u.ac.jp
authors.forename: Shuji
authors.initials: S
authors.lastname: Nagata
authors.forename: Robert K
authors.initials: RK
authors.lastname: Shen
authors.forename: Nadia N
authors.initials: NN
authors.lastname: Laack
authors.forename: Carrie Y
authors.initials: CY
authors.lastname: Inwards
authors.forename: Doris E
authors.initials: DE
authors.lastname: Wenger
authors.forename: Kimberly K
authors.initials: KK
authors.lastname: Amrami
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D002813:Chondrosarcoma / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D015831:Osteochondroma / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D016896:Treatment Outcome; D014916:Whole-Body Irradiation / Q000009:adverse effects*