title: [Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound].
abstract: OBJECTIVE
  To prepare membrane controlled tablets of puerarin sinclusion compound and to investigate the drug release in vitro.
  
  
  METHODS
  The single factors affecting drug release in vitro were investigated. Then, uniform design was used to optimize the formulation of controlled osmotic-pump tablets.
  
  
  RESULTS
  Drug release profiles in vitro were affected obviously by membrane thickness, penetrating agents and porogen.
  
  
  CONCLUSIONS
  Membrane controlled tablets of puerarin inclusion compound were prepared according to the optimal formulation with zero-order kinetics.
authors.affiliation: Southwest University for Nationalities, Chengdu 610041, China. 171949699@qq.com
authors.forename: E
authors.initials: E
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Tan
authors.forename: Jian
authors.initials: J
authors.lastname: Gu
authors.forename: Li-Li
authors.initials: LL
authors.lastname: He
authors.forename: Feng
authors.initials: F
authors.lastname: Yao
mesh_terms: D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry*; D007700:Kinetics; D012995:Solubility; D013607:Tablets / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D007529:Isoflavones; D013607:Tablets; C033607:puerarin