title: Right ventricular stroke work index as a negative predictor of mortality and initial hospital stay after lung transplantation.
abstract: BACKGROUND
  Studies have shown that patients with poor pre-lung transplant (LTx) right ventricular (RV) function have prolonged post-operative ventilation time and intensive care stay as well as a higher risk of in-hospital death. RV stroke work index (RVSWI) calculates RV workload and contractility. We hypothesized that patients with higher RV workload capacity, indicated by higher RVSWI, would have better outcomes after LTx.
  
  
  METHODS
  A retrospective record review was performed on all LTx patients between 2005 and 2011 who had right heart catheterizations (RHC) 1-year before LTx. In addition, results for echocardiograms and cardiopulmonary exercise testing within 1-year of RHCs were gathered.
  
  
  RESULTS
  Mean RVSWI was 9.36 ± 3.59 for 115 patients. There was a significant relation between mean pulmonary artery pressure (mPAP), RVSWI, RV end-diastolic diameter (RVEDd), left atrial dimension (LAD), peak and resting pressure of end-tidal carbon dioxide, minute ventilation /volume of carbon dioxide production, and 1-year mortality after LTx. Contrary to our hypothesis, those who survived had lower RVSWI than those who died within 1 year (8.99 ± 3.38 vs 11.6 ± 4.1, p = 0.026). Hospital length of stay significantly correlated with mPAP, RVSWI, left ventricular ejection fraction, percentage of fractional shortening, RVEDd, RV fractional area change, LAD, and RV wall thickness in diastole. Intensive care length of stay also significantly correlated with these variables and with body mass index. RVSWI was significantly different between groups of different RV function, indicating that increased RVSWI is associated with impairment of RV structure and function in patients undergoing LTx evaluation.
  
  
  CONCLUSIONS
  This study demonstrates an association between 1-year mortality, initial hospital and intensive care length of stay, and pre-LTx RVSWI. Increased mPAP is a known risk for outcomes in LTx patients. Our findings support this fact and also show increased mortality with elevation of RVSWI, demonstrating the value of RV function in the assessment of risk for pre-LTx patients.
authors.affiliation: Department of Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, NY, USA. hfa2104@columbia.edu
authors.forename: Hilary F
authors.initials: HF
authors.lastname: Armstrong
authors.forename: P Christian
authors.initials: PC
authors.lastname: Schulze
authors.forename: Tomoko S
authors.initials: TS
authors.lastname: Kato
authors.forename: Matthew
authors.initials: M
authors.lastname: Bacchetta
authors.forename: Wilawan
authors.initials: W
authors.lastname: Thirapatarapong
authors.forename: Matthew N
authors.initials: MN
authors.lastname: Bartels
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000601:surgery; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data*; D017563:Lung Diseases, Interstitial / Q000601:surgery; D016040:Lung Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D013318:Stroke Volume / Q000502:physiology*; D015996:Survival Rate; D016278:Ventricular Function, Right / Q000502:physiology*