title: Effect of single-session repetitive transcranial magnetic stimulation applied over the hand versus leg motor area on pain after spinal cord injury.
abstract: BACKGROUND
  Neuropathic pain often follows spinal cord injury (SCI).
  
  
  OBJECTIVE
  To compare the effect of repetitive transcranial magnetic stimulation (rTMS) applied over different motor cortex targets (hand vs leg area) versus sham stimulation on neuropathic pain and local neurophysiological changes in patients with SCI.
  
  
  METHODS
  A total of 16 patients with complete or incomplete motor SCI and chronic neuropathic pain participated in a double-blind, cross-over randomized study. Three single sessions of sham or active rTMS (10 Hz, total of 2000 stimuli) were applied in random order over the hand or leg area with a minimal 2-week interval. THE MAIN OUTCOME MEASURES: were the numeric rating scale for pain sensation and parameters derived from motor mapping of the first dorsal interosseous muscle, including maximal amplitude of evoked response as well as map area, volume, and location.
  
  
  RESULTS
  rTMS applied to either the hand or the leg area, but not sham stimulation, induced a significant but equivalent reduction in pain for the first 48 hours postintervention (P < .05). Participants with an incomplete lesion showed greater analgesia than those with a complete lesion (21% vs. 3%, respectively; P < .05). The main change observed for motor map measurements was an increase in corticospinal excitability after stimulation of the hand area (P = .04) but not for the other conditions.
  
  
  CONCLUSIONS
  rTMS applied over the hand or leg motor cortex decreased neuropathic pain regardless of any change in cortical excitability, suggesting that the analgesic effect is not associated with local changes at the motor cortex level itself.
authors.affiliation: Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Québec, QC, Canada.
authors.forename: Fanny
authors.initials: F
authors.lastname: Jetté
authors.forename: Isabelle
authors.initials: I
authors.lastname: Côté
authors.forename: Hadj Boumediene
authors.initials: HB
authors.lastname: Meziane
authors.forename: Catherine
authors.initials: C
authors.lastname: Mercier
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping; D018592:Cross-Over Studies; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D007839:Functional Laterality; D006112:Gravitation; D006225:Hand / Q000294:innervation*; D006801:Humans; D021621:Imaging, Three-Dimensional; D007866:Leg / Q000294:innervation*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology; D010146:Pain / Q000209:etiology* / Q000534:rehabilitation*; D010147:Pain Measurement; D013119:Spinal Cord Injuries / Q000150:complications* / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation
keywords: central pain; neuropathic pain; repetitive transcranial magnetic stimulation; spinal cord injury