title: Kisspeptin, leptin, and retinol-binding protein 4 in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To compare plasma kisspeptin, serum leptin, and serum retinol-binding protein 4 (RBP4) levels in women with and without polycystic ovary syndrome (PCOS) and to correlate these among each other and with clinical, hormonal, and metabolic parameters.
  
  
  METHODS
  Ninety women, including 54 women with PCOS and 36 without PCOS, participated in this study. For all patients, history and physical examinations were performed and blood samples were collected between days 3 and 8 of a spontaneous bleeding episode in the PCOS group and during normal menses of controls. Plasma kisspeptin, serum leptin, and serum RBP4 levels were measured using specific commercial assays.
  
  
  RESULTS
  Kisspeptin, leptin, and RBP4 levels were significantly higher in the PCOS group than in controls. Kisspeptin and RBP4 levels were significantly higher among obese PCOS patients than controls. Leptin levels were higher among obese PCOS patients than non-obese PCOS patients or controls. Kisspeptin and leptin levels of PCOS patients were significantly correlated with RBP4 levels. When only obese PCOS patients were analyzed, kisspeptin levels correlated with only the free androgen index.
  
  
  CONCLUSIONS
  These findings suggest that kisspeptin, leptin, and RBP4 are associated with metabolic disturbances in women with PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University, College of Medicine, Seoul 135-720, Korea.
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Jeon
authors.forename: Kyung Eun
authors.initials: KE
authors.lastname: Lee
authors.forename: Ji Ann
authors.initials: JA
authors.lastname: Jung
authors.forename: Su Youn
authors.initials: SY
authors.lastname: Yim
authors.forename: HyeYeon
authors.initials: H
authors.lastname: Kim
authors.forename: Seok Kyo
authors.initials: SK
authors.lastname: Seo
authors.forename: SiHyun
authors.initials: S
authors.lastname: Cho
authors.forename: Young Sik
authors.initials: YS
authors.lastname: Choi
authors.forename: Byung Seok
authors.initials: BS
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D059648:Kisspeptins / Q000097:blood*; D020738:Leptin / Q000097:blood*; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism*; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D012739:Gonadal Steroid Hormones; D007328:Insulin; C106628:KISS1 protein, human; D059648:Kisspeptins; D020738:Leptin; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma