title: Coagulation and fibrinolytic indices during the first trimester of pregnancy in women with polycystic ovary syndrome: a preliminary study.
abstract: OBJECTIVE
  To evaluate the levels of coagulation and fibrinolytic markers during the first trimester of pregnancy in women with polycystic ovary syndrome (PCOS) and determine the effects of PCOS and obesity on the levels of these hemostatic markers.
  
  
  METHODS
  A cross-sectional study was conducted in Beijing, China, on women with PCOS (n = 50), healthy women (n = 50), pregnant women with PCOS (n = 50), and healthy pregnant women (n = 50) at 12 weeks of pregnancy. Coagulation and fibrinolytic parameters were measured.
  
  
  RESULTS
  The interaction between PCOS and pregnancy appears to exert effects on the activities of coagulation factors VIII and X. The interaction between PCOS and obesity also seems to affect the level of von Willebrand factor.
  
  
  CONCLUSIONS
  Pregnant women with PCOS, especially women who are obese, are observed to be in a more prohemostatic state during the first trimester.
authors.affiliation: 1Obstetrics and Gynecology Department of Navy General Hospital of Chinese PLA, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Shan
authors.forename: Aiming
authors.initials: A
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.forename: Wen
authors.initials: W
authors.lastname: Jiang
authors.forename: Baosen
authors.initials: B
authors.lastname: Pang
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: An
authors.forename: Xin
authors.initials: X
authors.lastname: Du
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Huang
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D016022:Case-Control Studies; D002681:China; D003430:Cross-Sectional Studies; D005169:Factor VIII / Q000032:analysis; D005170:Factor X / Q000032:analysis; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D009765:Obesity / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D015415:Biomarkers; D014841:von Willebrand Factor; C078147:F8 protein, human; D005169:Factor VIII; D005170:Factor X
keywords: coagulation; fibrinolysis; obesity; polycystic ovary syndrome; pregnancy