title: Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments.
abstract: OBJECTIVE
  The aim of this study was to assess the feasibility of a hybrid ablative technique based on applying electroporation (EP) pulses just before conducting radiofrequency ablation (RFA). The rationale was that the EP-induced reduction in blood perfusion could be sufficient to reduce the thermal sink effect and hence to increase the coagulation volume in comparison to that created exclusively by RFA.
  
  
  METHODS
  A modelling study and in vivo experimental study were used. A Cool-tip RF applicator was used both for EP and RFA.
  
  
  RESULTS
  Overall, the results did not show any synergy effect from using the hybrid technique. Applying EP pulses prior to RFA did not increase the coagulation zone obtained and the lesions were almost identical. Additional computer simulations provided an explanation for this; the effect of reducing blood perfusion by thermal damage during RFA completely masks the effect of reducing blood perfusion by EP. This is because both thermal damage and EP affect the same zone, i.e. the tissue around the electrode.
  
  
  CONCLUSIONS
  Our computer modelling and in vivo experimental findings suggest that the combination of EP and RFA with monopolar applicators does not provide an additional benefit over the use of RFA alone.
authors.affiliation: Instituto Universitario de Matemática Pura y Aplicada, Universitat Politècnica de València, Spain.
authors.forename: Macarena
authors.initials: M
authors.lastname: Trujillo
authors.forename: Quim
authors.initials: Q
authors.lastname: Castellví
authors.forename: Fernando
authors.initials: F
authors.lastname: Burdío
authors.forename: Patricia
authors.initials: P
authors.lastname: Sánchez Velazquez
authors.forename: Antoni
authors.initials: A
authors.lastname: Ivorra
authors.forename: Anna
authors.initials: A
authors.lastname: Andaluz
authors.forename: Enrique
authors.initials: E
authors.lastname: Berjano
mesh_terms: D000818:Animals; D017115:Catheter Ablation; D003131:Combined Modality Therapy; D003198:Computer Simulation; D018274:Electroporation; D005240:Feasibility Studies; D005260:Female; D008099:Liver / Q000601:surgery; D008962:Models, Theoretical; D013552:Swine