title: New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population.
abstract: Most recently, 1-h hyperglycemia has been recognized as an additional risk factor for type 2 diabetes. To date, previous genome-wide association studies for glycemic traits have a limited impact on the fasting state and 2-h plasma glucose level in an oral glucose challenge. To identify genetic susceptibility in different stages of glucose tolerance, we performed a meta-analysis for glycemic traits including 1-h plasma glucose (1-hPG) from 14 232 non-diabetic individuals in the Korean population. Newly implicated variants (MYL2, C12orf51 and OAS1) were found to be significantly associated with 1-hPG. We also demonstrated associations with gestational diabetes mellitus. Our results could provide additional insight into the genetic variation in the clinical range of glycemia.
authors.affiliation: Division of Structural and Functional Genomics, Center for Genome Science, Korea National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
authors.forename: Min Jin
authors.initials: MJ
authors.lastname: Go
authors.forename: Joo-Yeon
authors.initials: JY
authors.lastname: Hwang
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Ji
authors.initials: J
authors.lastname: Hee Oh
authors.forename: Yeon-Jung
authors.initials: YJ
authors.lastname: Kim
authors.forename: Soo
authors.initials: S
authors.lastname: Heon Kwak
authors.forename: Kyung
authors.initials: K
authors.lastname: Soo Park
authors.forename: Juyoung
authors.initials: J
authors.lastname: Lee
authors.forename: Bong-Jo
authors.initials: BJ
authors.lastname: Kim
authors.forename: Bok-Ghee
authors.initials: BG
authors.lastname: Han
authors.forename: Myeong-Chan
authors.initials: MC
authors.lastname: Cho
authors.forename: Yoon Shin
authors.initials: YS
authors.lastname: Cho
authors.forename: Jong-Young
authors.initials: JY
authors.lastname: Lee
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001786:Blood Glucose / Q000032:analysis; D024722:Cardiac Myosins / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D016640:Diabetes, Gestational / Q000235:genetics; D005215:Fasting / Q000097:blood; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000097:blood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D018994:Myosin Light Chains / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D056910:Republic of Korea; D012307:Risk Factors; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D018994:Myosin Light Chains; C107184:myosin light chain 2; D044767:Ubiquitin-Protein Ligases; C475085:OAS1 protein, human; D015088:2',5'-Oligoadenylate Synthetase; D024722:Cardiac Myosins