title: Improvement of arterial stiffness in the transition from acute decompensated heart failure to chronic compensated heart failure.
abstract: BACKGROUND
  Pulse wave velocity (PWV) is a well-established marker for aortic stiffness and may be a prognostic factor in heart failure (HF). This study investigates whether PWV changes as patients transition from acute decompensated heart failure (ADHF) to chronic compensated heart failure (CCHF).
  
  
  OBJECTIVE
  Arterial stiffness is related with the development of HF.
  
  
  METHODS
  Regional PWV was prospectively measured using noninvasive applanation tonometry in consecutive ADHF patients (n = 55). PWV measurements of 45 patients were taken at admission and 3-month follow-up (F/U).
  
  
  RESULTS
  Central and upper-extremity PWV, but not lower-extremity PWVs, were found to have improved after 3 months compared with the admission PWV (central: 8.73 ± 1.17 vs 8.39 ± 0.99 m/s, P = 0.018; upper extremity: 8.59 ± 0.84 vs 8.33 ± 0.82 m/s, P = 0.028). Multivariate logistic regression analyses revealed that low-density lipoprotein cholesterol was significantly associated with the change of PWV in HF (odds ratio: 1.037, 95% confidence interval: 1.003-1.071, P = 0.030). In preserved left ventricular ejection fraction patients (n = 26) and ischemic patients (n = 31), central and upper-extremity PWVs improved over the admission PWV at 3-month F/U.
  
  
  CONCLUSIONS
  The present results indicate that central and upper-extremity PWVs, but not lower-extremity PWV, are increased in ADHF and improve as patients transition from ADHF to CCHF.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Dong-Bin
authors.initials: DB
authors.lastname: Kim
authors.forename: Sang Hong
authors.initials: SH
authors.lastname: Baek
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Jang
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Her
authors.forename: Dong-Il
authors.initials: DI
authors.lastname: Shin
authors.forename: Chan Seok
authors.initials: CS
authors.lastname: Park
authors.forename: Hoon Joon
authors.initials: HJ
authors.lastname: Park
authors.forename: Pum Joon
authors.initials: PJ
authors.lastname: Kim
authors.forename: Hae Ok
authors.initials: HO
authors.lastname: Jung
authors.forename: Ki Bae
authors.initials: KB
authors.lastname: Seung
mesh_terms: D000208:Acute Disease; D000368:Aged; D016009:Chi-Square Distribution; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D016015:Logistic Models; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D013318:Stroke Volume; D013997:Time Factors; D034941:Upper Extremity / Q000098:blood supply*; D059289:Vascular Stiffness; D016277:Ventricular Function, Left