title: Causes of death of patients with laryngeal cancer.
abstract: Despite remarkable advances in the care of patients with laryngeal cancer over the past several decades, including a growing awareness of therapeutic complications and attention to quality of life, little is known about the causes of mortality in this population. In addition to the laryngeal malignancy itself, acute and late or chronic treatment-associated causes, second primary cancers, intercurrent disease and psychosocial factors are all responsible for patient morbidity and mortality. We examine the current literature related to the causes of death in patients with laryngeal cancer, in the hope of guiding future interventions to improve the longevity and quality of life of individuals with this cancer.
authors.affiliation: ENT Clinic, University of Udine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy, a.ferlito@uniud.it.
authors.forename: Alfio
authors.initials: A
authors.lastname: Ferlito
authors.forename: Missak
authors.initials: M
authors.lastname: Haigentz
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Bradley
authors.forename: Carlos
authors.initials: C
authors.lastname: Suárez
authors.forename: Primož
authors.initials: P
authors.lastname: Strojan
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Wolf
authors.forename: Kerry D
authors.initials: KD
authors.lastname: Olsen
authors.forename: William M
authors.initials: WM
authors.lastname: Mendenhall
authors.forename: Vanni
authors.initials: V
authors.lastname: Mondin
authors.forename: Juan P
authors.initials: JP
authors.lastname: Rodrigo
authors.forename: Carsten C
authors.initials: CC
authors.lastname: Boedeker
authors.forename: Marc
authors.initials: M
authors.lastname: Hamoir
authors.forename: Dana M
authors.initials: DM
authors.lastname: Hartl
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Hunt
authors.forename: Kenneth O
authors.initials: KO
authors.lastname: Devaney
authors.forename: Lester D R
authors.initials: LD
authors.lastname: Thompson
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rinaldo
authors.forename: Robert P
authors.initials: RP
authors.lastname: Takes
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000401:mortality*; D002423:Cause of Death; D006258:Head and Neck Neoplasms / Q000401:mortality*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality*; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D016609:Neoplasms, Second Primary / Q000401:mortality*; D000077195:Squamous Cell Carcinoma of Head and Neck; D013405:Suicide / Q000706:statistics & numerical data*; D016312:Treatment Refusal / Q000706:statistics & numerical data