title: Nanotechnology approaches for ocular drug delivery.
abstract: Blindness is a major health concern worldwide that has a powerful impact on afflicted individuals and their families, and is associated with enormous socio-economical consequences. The Middle East is heavily impacted by blindness, and the problem there is augmented by an increasing incidence of diabetes in the population. An appropriate drug/gene delivery system that can sustain and deliver therapeutics to the target tissues and cells is a key need for ocular therapies. The application of nanotechnology in medicine is undergoing rapid progress, and the recent developments in nanomedicine-based therapeutic approaches may bring significant benefits to address the leading causes of blindness associated with cataract, glaucoma, diabetic retinopathy and retinal degeneration. In this brief review, we highlight some promising nanomedicine-based therapeutic approaches for drug and gene delivery to the anterior and posterior segments.
authors.affiliation: Department of Ophthalmology, Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Xu
authors.forename: Siva P
authors.initials: SP
authors.lastname: Kambhampati
authors.forename: Rangaramanujam M
authors.initials: RM
authors.lastname: Kannan
mesh_terms: D016503:Drug Delivery Systems; D005128:Eye Diseases / Q000628:therapy*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D050997:Nanomedicine / Q000639:trends; D036103:Nanotechnology / Q000379:methods*
keywords: Age-Related Macular Degeneration; Dendrimers; Nanoparticles; Ocular Gene Therapy; Targeted Therapies