title: Inflammation in atherothrombotic disease.
abstract: Atherosclerosis is a systemic disease in which vascular inflammation plays a key role. Indeed, inflammation is closely linked to atherosclerotic disease at all stages, from silent progression to clinical manifestations. There is now strong epidemiologic evidence that mediators of inflammation, like C-reactive protein, predict cardiovascular risk independently of "classical" risk factors. Consequently, new disease-modifying drugs targeting inflammation are under investigation and may change the approach to treatment of atherosclerosis in the near future.
authors.affiliation: Department of Medicine, Montreal Heart Institute, University of Montreal, 5000 Belanger East, Montreal, QC H1T IC8, Canada. Philippe.lallier@sympatico.ca
authors.forename: Philippe L
authors.initials: PL
authors.lastname: L'Allier
mesh_terms: D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000502:physiology; D023201:CD40 Ligand / Q000378:metabolism; D003324:Coronary Artery Disease / Q000473:pathology; D023903:Coronary Restenosis / Q000378:metabolism; D018450:Disease Progression; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D018384:Oxidative Stress
chemical_list: D023201:CD40 Ligand; D002097:C-Reactive Protein