title: [G6PD deficiency among children under 7 years old from Yunnan with unique ethnic minority origin].
abstract: OBJECTIVE
  To investigate the epidemiological status of glucose-6-phosphate dehydrogenase (G6PD) deficiency among children from Yunnan with unique ethnic origins.
  
  
  METHODS
  DNA samples from 11759 children were tested with fluorescent spot test, G6PD/6PGD quantitative ratio assay and hemoglobin electrophoresis.
  
  
  RESULTS
  The detection rate of G6PD deficiency was 2.5%, for which boys were significantly greater than girls (3.5% vs. 1.4%, P<0.05). Significant differences were also detected among children from different ethnic groups and different regions. For ethnic Han Chinese, the detection rate was 0.7%, which was lower than the majority of ethnic minorities. By regression analysis, altitude of residence and family history both have significant influence on the calculated rate.
  
  
  CONCLUSIONS
  Occurrence of G6PD deficiency seems to be influenced by gender. It also varies substantially between different ethnic groups as well as regions, e.g., more common in south. It also showed a declining trend after years of diagnosis and intervention. This survey may provide a valuable basis for counseling of G6PD deficiency in Yunnan.
authors.affiliation: Yunnan Maternal and Child Health Hospital, Kunming, P.R. China.
authors.forename: Li-qin
authors.initials: LQ
authors.lastname: Yao
authors.forename: Tuan-biao
authors.initials: TB
authors.lastname: Zou
authors.forename: Xing-tian
authors.initials: XT
authors.lastname: Wang
authors.forename: Xing
authors.initials: X
authors.lastname: Quan
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.forename: Fa-bin
authors.initials: FB
authors.lastname: Yang
authors.forename: Li-sha
authors.initials: LS
authors.lastname: Hu
authors.forename: Li-mei
authors.initials: LM
authors.lastname: Fan
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Xi-yun
authors.initials: XY
authors.lastname: Feng
authors.forename: Jin-tao
authors.initials: JT
authors.lastname: Liu
authors.forename: Zhong-ming
authors.initials: ZM
authors.lastname: Zhao
mesh_terms: D002648:Child; D002675:Child, Preschool; D002681:China / Q000208:ethnology; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000208:ethnology* / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male