title: Anti-oxidative role of quercetin derived from Allium cepa on aldehyde oxidase (OX-LDL) and hepatocytes apoptosis in streptozotocin-induced diabetic rat.
abstract: OBJECTIVE
  To study the role of Quercetin in streptozotocin-induced diabetes in rats.
  
  
  METHODS
  Wistar male rat (n=40) were allocated into three groups, control group (n=10) and Quercetin (QR) group received 15 mg/kg (IP) QR, (n=10), and diabetic group that received 55 mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10; STZ group and treatment group. Treatment group received 55 mg/kg (IP) STZ plus 15 mg/kg QR, daily for 4 weeks, respectively; however, the control group just received an equal volume of distilled water daily (IP). Diabetes was induced by a single (IP) injection of streptozotocin (55 mg/kg). Animals were kept in standard condition. Twenty-eight days after inducing diabetic, 5 mL blood were collected for TAC, MDA and Ox-LDL levels and liver tissues of rat in whole groups were removed then prepared for apoptosis analysis by Tunel method.
  
  
  RESULTS
  Apoptotic cells significantly decreased in group that has received 15 mg/kg (IP) Quercetin (P<0.05) in comparison to experimental groups (P<0.05).
  
  
  CONCLUSIONS
  Since in our study 15 mg/kg (IP) Quercetin have significantly Preventive effect on liver cells damages by reducing number of apoptotic cells in Liver, so it seems that using it can be effective for treatment in diabetic rat.
authors.affiliation: Member of Medicine Scientific Association, Islamic Azad University, Tabriz Branch, Tabriz, Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Bakhshaeshi
authors.forename: Arash
authors.initials: A
authors.lastname: Khaki
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Fathiazad
authors.forename: Amir Afshin
authors.initials: AA
authors.lastname: Khaki
authors.forename: Elham
authors.initials: E
authors.lastname: Ghadamkheir
mesh_terms: D042931:Aldehyde Oxidase / Q000037:antagonists & inhibitors; D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000627:therapeutic use; D017209:Apoptosis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000627:therapeutic use; D022781:Hepatocytes / Q000187:drug effects / Q000502:physiology*; D008077:Lipoproteins, LDL / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D019697:Onions / Q000737:chemistry*; D011794:Quercetin / Q000302:isolation & purification / Q000627:therapeutic use*; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D000975:Antioxidants; D004791:Enzyme Inhibitors; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D013311:Streptozocin; D011794:Quercetin; D042931:Aldehyde Oxidase
keywords: Apoptosis; Diabetic; Liver; Quercetin; Rat; Streptozotocin