title: SAPHO syndrome--a pictorial assay.
abstract: SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a distinct clinical entity representing involvement of the musculoskeletal and dermatologic systems. It is well known to rheumatologists because of characteristic skin manifestations and polyarthropathy. However, few reports exist in the orthopaedic literature. It is important to be aware of sAPHO syndrome as it can mimic some of the more common disease entities such as infection, tumor, and other inflammatory arthropathies. Anterior chest wall pain centered at sternoclavicular and sternocostal joints is an important and characteristic clinical finding which can point to its diagnosis. A patient may undergo different diagnostic tests and invasive procedures such as biopsies before a diagnosis is made. Imaging can be helpful by offering a detailed evaluation of the abnormalities. More importantly it helps in revealing subclinical foci of involvement due to the polyostotic nature of the disease. The treatment is mostly nonsurgical. NSAIDS are the first line agents. However multiple new agents are being used for refractory cases. Surgery is reserved to treat complications.
authors.affiliation: Musculoskeletal Radiology Section, Department of Radiology, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.
authors.forename: Lokesh
authors.initials: L
authors.lastname: Khanna
authors.forename: Georges Y
authors.initials: GY
authors.lastname: El-Khoury
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000175:diagnosis* / Q000628:therapy*; D003937:Diagnosis, Differential; D006801:Humans