title: Fibrillar amyloid correlates of preclinical cognitive decline.
abstract: BACKGROUND
  It is not known whether preclinical cognitive decline is associated with fibrillar β-amyloid (Aβ) deposition irrespective of apolipoprotein E (APOE) ε4 status.
  
  
  METHODS
  From a prospective observational study of 623 cognitively normal individuals, we identified all subjects who showed preclinical decline of at least 2 standard deviations beyond the decline of the entire group in memory or executive function. Fourteen decliners were matched by APOE ε4 gene dose, age, sex, and education with 14 nondecliners. Dynamic Pittsburgh compound B (PiB) positron emission tomography (PET) scans, the Logan method, statistical parametric mapping, and automatically labeled regions of interest were used to characterize and compare cerebral-to-cerebellar PiB distribution volume ratios (DVRs), reflecting fibrillar Aβ burden.
  
  
  RESULTS
  At P < .005 (uncorrected), decliners had significantly greater DVRs in comparison to nondecliners.
  
  
  CONCLUSIONS
  Asymptomatic longitudinal neuropsychological decline is associated with subsequent increased fibrillar amyloid deposition, even when controlling for APOE ε4 genotype.
authors.affiliation: Department of Psychiatry & Psychology, Mayo Clinic in Arizona, Scottsdale, AZ, USA. Electronic address: stonnington.cynthia@mayo.edu.
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Stonnington
authors.affiliation: Banner Alzheimer's Institute, Phoenix, AZ, USA.
authors.forename: Kewei
authors.initials: K
authors.lastname: Chen
authors.affiliation: Banner Alzheimer's Institute, Phoenix, AZ, USA.
authors.forename: Wendy
authors.initials: W
authors.lastname: Lee
authors.affiliation: Department of Psychiatry & Psychology, Mayo Clinic in Arizona, Scottsdale, AZ, USA.
authors.forename: Dona E C
authors.initials: DE
authors.lastname: Locke
authors.affiliation: Department of Biostatistics, Mayo Clinic in Arizona, Scottsdale, AZ, USA.
authors.forename: Amylou C
authors.initials: AC
authors.lastname: Dueck
authors.affiliation: Banner Alzheimer's Institute, Phoenix, AZ, USA.
authors.forename: Xiaofen
authors.initials: X
authors.lastname: Liu
authors.affiliation: Banner Alzheimer's Institute, Phoenix, AZ, USA.
authors.forename: Auttawut
authors.initials: A
authors.lastname: Roontiva
authors.affiliation: Banner Alzheimer's Institute, Phoenix, AZ, USA; Department of Neurosciences, University of California-San Diego, San Diego, CA, USA.
authors.forename: Adam S
authors.initials: AS
authors.lastname: Fleisher
authors.affiliation: Department of Neurology, Mayo Clinic in Arizona, Scottsdale, AZ, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Caselli
authors.affiliation: Banner Alzheimer's Institute, Phoenix, AZ, USA.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Reiman
mesh_terms: D000368:Aged; D000682:Amyloid / Q000378:metabolism*; D000814:Aniline Compounds; D053327:Apolipoprotein E4 / Q000235:genetics; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D001931:Brain Mapping; D003072:Cognition Disorders / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000000981:diagnostic imaging / Q000209:etiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D019370:Observation; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000682:Amyloid; D000814:Aniline Compounds; D053327:Apolipoprotein E4; D013844:Thiazoles
keywords: Alzheimer's disease; Amyloid imaging; Apolipoprotein E; Cognitive decline; Preclinical