title: [Development of elastameric sealant designed for arterial field].
abstract: The development of a reliable surgical sealant specific for arterial tissues has been long awaited. In this article, first the "ideal" adhesion mechanism formulated from biomechanical concept is proposed for ensured hemostasis in dissected arteries with pulsatile flow. An urethane prepolymer prepared along the design criteria is viscous liquid. Due to its high water absorbility and high reactivity with water, the sealant applied to vascular tissues becomes an elastomer within several minutes. When the sealant was applied to dissected canine abdominal arteries with 3 stay sutures, followed by declamping 5 minutes, neither bleeding nor detrimental effect on tissue morphogenesis was observed. This sealant is being ready to the market.
authors.affiliation: Genome Biotechnology Laboratory, Kanazawa Institute of Technology, Hakusan, Japan.
authors.forename: Takehisa
authors.initials: T
authors.lastname: Matsuda
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Nakajima
mesh_terms: D000818:Animals; D001158:Arteries / Q000601:surgery*; D004285:Dogs; D011108:Polymers; D014014:Tissue Adhesives; D014520:Urethane
chemical_list: D011108:Polymers; D014014:Tissue Adhesives; D014520:Urethane