title: Correlation between expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinase-2 and cervical lymph node metastasis of nasopharyngeal carcinoma.
abstract: OBJECTIVE
  We evaluated the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-2 (MMP-2) in nasopharyngeal carcinoma (NPC) and studied their relationship with cervical lymph node metastasis.
  
  
  METHODS
  Immunohistochemical staining was used to detect the expression of EMMPRIN and MMP-2 in specimens from patients with chronic nasopharyngitis (CN), nonmetastastic NPC (NM-NPC), and lymph node-metastatic NPC (LNM-NPC).
  
  
  RESULTS
  The rates of positive EMMPRIN expression in CN, NM-NPC, and LNM-NPC were 13.3%, 30.0%, and 66.7%, respectively. Significant differences were found between the rates in CN and LNM-NPC (p <0.01) and between the rates in NM-NPC and LNM-NPC (p = 0.01). In the LNM-NPC group, NPC cells had a higher rate of expression of EMMPRIN in tumor metastases than in the primary tumor (81.8% versus 66.7%; p = 0.01). The rates of positive MMP-2 expression in CN, NM-NPC, and LNM-NPC were 13.3%, 35.0%, and 60.6%, respectively. A significant difference was found between the rates in CN and LNM-NPC (p < 0.01). In the LNM-NPC group, NPC cells had a higher rate of MMP-2 expression in tumor metastases than in the primary tumor (72.7% versus 60.6%; p <0.01). The expressions of MMP-2 and EMMPRIN were highly correlated (rs = 0.466; p <0.01).
  
  
  CONCLUSIONS
  Nasopharyngeal carcinoma cells may attain enhanced metastastic capability through the expression of MMP-2 induced by EMMPRIN.
authors.affiliation: Institute of Inflammation and Immune Diseases, Shantou University Medical College, Shantou, People's Republic of China.
authors.forename: Tian
authors.initials: T
authors.lastname: Huang
authors.forename: Mao-Huai
authors.initials: MH
authors.lastname: Chen
authors.forename: Ming-Yao
authors.initials: MY
authors.lastname: Wu
authors.forename: Xian-Ying
authors.initials: XY
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D051926:Basigin / Q000378:metabolism*; D002277:Carcinoma / Q000201:enzymology* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000201:enzymology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000201:enzymology* / Q000378:metabolism* / Q000473:pathology; D009304:Nasopharyngitis / Q000201:enzymology; D009333:Neck; D009361:Neoplasm Invasiveness; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: C497886:BSG protein, human; D051926:Basigin; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2