title: Lethal malaria: Marchiafava and Bignami were right.
abstract: One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal falciparum malaria was microvascular obstruction. Since then, several alternative hypotheses have been proposed. These formed the basis for adjunctive interventions, which have either been ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami were right.
authors.affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. nickw@tropmedres.ac
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
authors.forename: Gareth D H
authors.initials: GD
authors.lastname: Turner
authors.forename: Nicholas P J
authors.initials: NP
authors.lastname: Day
authors.forename: Arjen M
authors.initials: AM
authors.lastname: Dondorp
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008288:Malaria / Q000097:blood / Q000188:drug therapy / Q000469:parasitology / Q000473:pathology*; D055806:Microvessels / Q000187:drug effects / Q000473:pathology*; D010963:Plasmodium falciparum / Q000502:physiology
chemical_list: D000962:Antimalarials
keywords: P. falciparum; cerebral malaria; malaria; pathology