title: Revaluation of breast cytology with pathologist on-site of lesions with suspicious sonographic features.
abstract: OBJECTIVE
  Evaluating correlation estimation between diagnostic ultrasound (U.S.) of breast lesions and fine needle aspiration cytology (FNAC), and the correlation between cytology and histology (I) of these lesions undergo surgery.
  
  
  METHODS
  In 2010 we performed 1589 ultrasound breast. We identified 210 suspicious lesions to be subjected to FNAC, which was performed with pathologist on site, and extemporaneous analysis of the sample to assess their appropriateness. We classified the lesions in 5 ultrasound (U) classes according to the criteria defined by Echographic BIRADS Lexicon. The results of cytology were classified in 5 classes (C) according to the guidelines of F.O.N.Ca.M. Then we evaluated the diagnostic correlation between U.S. and FNAC, and between FNAC and Histology.
  
  
  RESULTS
  The distribution of lesions in U classes was: 57U2, 55U3, 36U4 and 62U5. The diagnostic concordance between U and FNAC was 96.7%, with a sensitivity of 98%, specificity 93%, negative and positive predictive value respectively of 94.9% and 97.3%, and diagnostic accuracy of 96.6%. The 98 patients with C4-C5 lesions were subjected to surgery and the histology confirmed high-grade malignancy of lesions with a concordance of 99.7%.
  
  
  CONCLUSIONS
  Having achieved high diagnostic concordance between U and FNAC, and then between FNAC and histology, we may say that the FNAC, less invasive and traumatic for the patient than needle biopsy (CB), may be still a valid method when performed with pathologist on-site to assess the adequacy of the sample taken.
authors.affiliation: Scuola di Specializzazione di Radiologia Diagnostica ed Interventistica, Università degli Studi di Milano Via Di Rudinì, Milano 20142, Italy. emanuelacapalbo@tiscalinet.it
authors.forename: Emanuela
authors.initials: E
authors.lastname: Capalbo
authors.forename: Farideh
authors.initials: F
authors.lastname: Sajadidehkordi
authors.forename: Claudio
authors.initials: C
authors.lastname: Colombi
authors.forename: Vladimira
authors.initials: V
authors.lastname: Ticha
authors.forename: Angela
authors.initials: A
authors.lastname: Moretti
authors.forename: Michela
authors.initials: M
authors.lastname: Peli
authors.forename: Maria
authors.initials: M
authors.lastname: Cosentino
authors.forename: Maria
authors.initials: M
authors.lastname: Lovisatti
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Berti
authors.forename: Maurizio
authors.initials: M
authors.lastname: Cariati
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000706:statistics & numerical data*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary / Q000706:statistics & numerical data*; D055815:Young Adult
keywords: Breast cancer; Cytology; FNAC; Ultrasound