title: Complete genome analyses of G4P[6] rotavirus detected in Argentinean children with diarrhoea provides evidence of interspecies transmission from swine.
abstract: Rotaviruses are dynamic pathogens that have been shown to infect multiple species. In 2006, two G4P[6] rotavirus strains with porcine characteristics were detected in Santa Fe, Argentina. To further characterize and determine the origin of these strains, nearly the full length of their genome was sequenced. While most of the genome segments were from porcine origin, the two strains grouped in different phylogenetic clusters in five out of the 11 genes, suggesting two independent interspecies transmission events. This study expands our knowledge of G4 rotavirus and reinforces the use of complete genome analyses as a key tool for diversity and evolution mechanicisms.
authors.affiliation: Instituto Nacional de Enfermedades Infecciosas (ANLIS 'Dr Carlos G. Malbrán'), Buenos Aires, Argentina. jdegiuseppe@anlis.gov.ar
authors.forename: J I
authors.initials: JI
authors.lastname: Degiuseppe
authors.forename: J C
authors.initials: JC
authors.lastname: Beltramino
authors.forename: A
authors.initials: A
authors.lastname: Millán
authors.forename: J A
authors.initials: JA
authors.lastname: Stupka
authors.forename: G I
authors.initials: GI
authors.lastname: Parra
mesh_terms: D000818:Animals; D001118:Argentina / Q000453:epidemiology; D016000:Cluster Analysis; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology*; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D012401:Rotavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D017422:Sequence Analysis, DNA; D013552:Swine; D015047:Zoonoses / Q000453:epidemiology / Q000635:transmission / Q000821:virology*
chemical_list: D012367:RNA, Viral
keywords: Argentina; G4P[6]; interspecies transmission; porcine-like strains; rotavirus