title: Allele frequency distribution of CYP2C9 2 and CYP2C9 3 polymorphisms in six Mexican populations.
abstract: Allele frequency differences of functional CYP2C9 polymorphisms are responsible for some of the variation in drug response observed in human populations. The most relevant CYP2C9 functional variants are CYP2C9*2 (rs1799853) and CYP2C9 3 (rs1057910). These polymorphisms show variation in allele frequencies among different population groups. The present study aimed to analyze these polymorphisms in 947 Mexican-Mestizo from Mexico City and 483 individuals from five indigenous Mexican populations: Nahua, Teenek, Tarahumara, Purepecha and Huichol. The CYP2C9*2 allele frequencies in the Mestizo, Nahua and Teenek populations were 0.051, 0.007 and 0.005, respectively. As for CYP2C9 3, the allelic frequencies in the Mestizo, Nahua and Teenek populations were 0.04, 0.005 and 0.005, respectively. The CYP2C9 2 and CYP2C9 3 alleles were not observed in the Tarahumara, Purepecha and Huichol populations. These findings are in agreement with previous studies reporting very low allele frequencies for these polymorphisms in American Indigenous populations.
authors.affiliation: Unidad de Investigación Médica en Bioquímica Centro Médico Nacional, "Siglo XXI" IMSS, Mexico.
authors.forename: Osvaldo D
authors.initials: OD
authors.lastname: Castelán-Martínez
authors.forename: Carlos
authors.initials: C
authors.lastname: Hoyo-Vadillo
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Sandoval-García
authors.forename: Lucila
authors.initials: L
authors.lastname: Sandoval-Ramírez
authors.forename: Miriam
authors.initials: M
authors.lastname: González-Ibarra
authors.forename: Gloria
authors.initials: G
authors.lastname: Solano-Solano
authors.forename: Rita A
authors.initials: RA
authors.lastname: Gómez-Díaz
authors.forename: Esteban J
authors.initials: EJ
authors.lastname: Parra
authors.forename: Miguel
authors.initials: M
authors.lastname: Cruz
authors.forename: Adán
authors.initials: A
authors.lastname: Valladares-Salgado
mesh_terms: D000483:Alleles; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D065729:Cytochrome P-450 CYP2C9; D005787:Gene Frequency; D005838:Genotype; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D008800:Mexico / Q000208:ethnology; D020641:Polymorphism, Single Nucleotide
chemical_list: C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases