title: Is living close to ophiolites related to asbestos related diseases? Cross-sectional study.
abstract: OBJECTIVE
  To determine the rate of pleural plaques and malignant mesothelioma and other factors that affect people living close to ophiolites.
  
  
  METHODS
  The study population was comprised of 2970 volunteers who resided <10 km from an ophiolitic unit. Control group comprised of 157 residents >25 km from ophiolites. Information gathered from the patients included presence of pleural plaques on chest X-ray, distance from ophiolites, gender, smoking status, duration of asbestos exposure, and body mass index (BMI). Mineralogical analysis of soil and rock samples was performed by X-ray diffraction.
  
  
  RESULTS
  Among the 2970 study participants, those who lived close to ophiolites, 9.8% had asbestos related disease (3 malignant mesothelioma, 289 pleural plaques). No asbestos related disease (ARD) was identified in the control group. Male gender (OR: 2.63, 95% 1.9-3.5, p < 0.001), advanced age (5% increase for every year p < 0.001), residential proximity to ophiolites (for every 1 km proximity, a 12% increase p < 0.001), and low BMI (for every 1 unit decrease, 3.6% increase p < 0.001) were associated with increased risk of ARD.
  
  
  CONCLUSIONS
  The rate of ARD is higher in residents living close to ophiolites. Important risk factors for developing ARD were age, male gender, proximity to an ophiolite site, and low BMI.
authors.affiliation: Department of Thoracic Surgery, Sivas Numune Hospital, Sivas, Turkey. drdongel@hotmail.com
authors.forename: Isa
authors.initials: I
authors.lastname: Döngel
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bayram
authors.forename: Nur Dilek
authors.initials: ND
authors.lastname: Bakan
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Yalçın
authors.forename: Sefa
authors.initials: S
authors.lastname: Gültürk
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001194:Asbestos / Q000032:analysis / Q000633:toxicity*; D015992:Body Mass Index; D002273:Carcinogens / Q000032:analysis / Q000633:toxicity; D003252:Construction Materials / Q000633:toxicity; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D006798:Housing / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D010995:Pleural Diseases / Q000453:epidemiology / Q000209:etiology*; D012111:Residence Characteristics; D012307:Risk Factors; D012737:Sex Factors; D012987:Soil / Q000032:analysis; D014421:Turkey / Q000453:epidemiology
chemical_list: D002273:Carcinogens; D012987:Soil; D001194:Asbestos