title: Bioassay of Eucalyptus extracts for anticancer activity against Ehrlich ascites carcinoma (eac) cells in Swiss albino mice.
abstract: OBJECTIVE
  To evaluate the antineoplastic activity of Eucalyptus extract (EuE) against Ehrlich ascites carcinoma (EAC) in Swiss albino mice.
  
  
  METHODS
  Preliminary examination of four plant extracts (namely Eucalyptus, Costus, Azadirachta, Feronia) has been done by observing the reduction ability of number of EAC cells in previously inoculated Swiss albino mice. Among them as EuE showed maximum capability, the whole study has been conducted with EuE only. Important parameters viz. enhancement of life span, reduction of average tumor weight etc. have been studied. In addition the effects of EuE on hematological parameters in both normal and EAC inoculated mice have been measured. Effect of EuE on normal peritoneal cells has also been studied.
  
  
  RESULTS
  : EuE reduced tumor burden remarkably. It reduced the tumor growth rate and enhanced the life span of EAC bearing mice noticeably. It reversed back the hematological parameters towards normal, reduced the trasplantability of EAC cells and enhanced the immunomodulatory effects in mice. The host toxic effect of EuE in mice is minimum and mostly reversible with time. All such data have been compared with those obtained by running parallel experiments with bleomycin at dose 0.3 mg/kg (i.p.).
  
  
  CONCLUSIONS
  The Eucalyptus extract may be considered as a potent anticancer agent for advanced researches.
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Science,University of Rajshahi, Rajshahi-6205, Bangladesh.
authors.forename: Farhadul
authors.initials: F
authors.lastname: Islam
authors.forename: Hasina
authors.initials: H
authors.lastname: Khatun
authors.forename: Soby
authors.initials: S
authors.lastname: Ghosh
authors.forename: M M
authors.initials: MM
authors.lastname: Ali
authors.forename: J A
authors.initials: JA
authors.lastname: Khanam
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis; D001681:Biological Assay; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004354:Drug Screening Assays, Antitumor; D005052:Eucalyptus / Q000737:chemistry*; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation; D051379:Mice; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: Antineoplastic activity; Ehrlich ascites carcinoma cells; Eucalyptus extract; Swiss albino mice