title: [Intravenous antibiotic therapy for acute hematogenous osteomyelitis in children: short versus long course].
abstract: The aim of this study was to evaluate the results of two antibiotic therapy protocols for osteomyelitis with different durations of intravenous treatment. This was a prospective randomized study of children treated for acute hematogenous osteomyelitis. Patients in group 1 (G1) received 7 days of intravenous antibiotics, whereas patients in group 2 (G2) received 14 days. Treatment was deemed effective if there were no signs of chronic osteomyelitis at the last follow-up. Fifty-three patients were included in the study (G1=27, G2=26). After a mean follow-up of 11.5 months, none of the patients in either group showed signs of chronic osteomyelitis. In conclusion, a shortened treatment of 7 days of intravenous antibiotic therapy is as effective as a longer treatment.
authors.affiliation: Service d'orthopédie de l'enfant et de l'adolescent, hôpital d'enfants de Tunis, 1007 Tunis Jabbari, Bab Saadoun, Tunisie. sami.bouchoucha@yahoo.com
authors.forename: S
authors.initials: S
authors.lastname: Bouchoucha
authors.forename: K
authors.initials: K
authors.lastname: Gafsi
authors.forename: M
authors.initials: M
authors.lastname: Trifa
authors.forename: W
authors.initials: W
authors.lastname: Saied
authors.forename: C
authors.initials: C
authors.lastname: Ammar
authors.forename: M N
authors.initials: MN
authors.lastname: Nessib
authors.forename: M
authors.initials: M
authors.lastname: Smida
authors.forename: M
authors.initials: M
authors.lastname: Ben Ghachem
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016470:Bacteremia / Q000188:drug therapy*; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005602:France; D019983:Guideline Adherence; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D009894:Opportunistic Infections / Q000188:drug therapy; D010019:Osteomyelitis / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D013203:Staphylococcal Infections / Q000188:drug therapy; D013290:Streptococcal Infections / Q000188:drug therapy; D013297:Streptococcus pyogenes
chemical_list: D000900:Anti-Bacterial Agents