title: Antioxidant and cytotoxic activity of Acanthus ilicifolius flower.
abstract: OBJECTIVE
  To investigate the antioxidant and cytotoxic activity of the flower of Acanthus ilicifolius (A. ilicifolius).
  
  
  METHODS
  Antioxidant activity was determined as antiradical efficiency with diphenyl picrylhydrazil (DPPH) method and cytotoxic assay was undertaken using brine shrimp lethal toxicity test.
  
  
  RESULTS
  A. ilicifolius flower contained terpenoid, phenolic compounds, and alkaloid. The methanol extract of A. ilicifolius flower showed the highest antiradical efficiency (AE=1.41×10(-3)) against DPPH radicals and the highest cytotoxicity (LC50=22 µg/mL) against brine shrimp nauplii.
  
  
  CONCLUSIONS
  It is suggested that active compounds of A. ilicifolius flower solved in methanol play a role to inhibit free radical activity and kill Artemia salina nauplii. The substances can be considered as potential antioxidant and cytotoxic agents as well as imminent candidate for cancer therapy.
authors.affiliation: Laboratory of Biochemistry, Faculty of Fisheries and Marine Science, Brawijaya University, Malang-65145, Indonesia.
authors.forename: Muhamad
authors.initials: M
authors.lastname: Firdaus
authors.forename: Asep Awaludin
authors.initials: AA
authors.lastname: Prihanto
authors.forename: Rahmi
authors.initials: R
authors.lastname: Nurdiani
mesh_terms: D027901:Acanthaceae / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects*; D001713:Biphenyl Compounds / Q000737:chemistry / Q000494:pharmacology; D003603:Cytotoxins / Q000633:toxicity*; D035264:Flowers / Q000737:chemistry*; D007928:Lethal Dose 50; D010851:Picrates / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D003603:Cytotoxins; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Acanthus ilicifolius; Antioxidant; Cytotoxic; Flower