title: [The treatment of chemotherapy-induced anemia in lung cancer patients].
abstract: Anemia is common among patients with malignant tumors, due to the disease and chemotherapy. Active oncotherapy, combination chemotherapy of lung cancer is accompanied with many side effects which may impair the patient's quality of life and compromise the effectiveness of chemotherapy, the most frequent one of them being chemotherapy-induced anemia. Anemia decreases not only the patient's quality of life, but also worsens the dose-intensity of chemotherapy. One of the potential treatments of chemotherapy-induced anemia is erythropoietin-stimulating agents (ESAs) for the appropriate indications. Several national and international studies have shown that ESA therapy effectively increases hemoglobin level. However, more recently, contradictory results were published on ESA treatment in terms of survival and tumor progression. The reason for this may be that the tumor cells and endothelial cells may as well express erythropoietin receptor, the role of which has not yet been fully elucidated in tumor progression.
authors.affiliation: Pulmonológiai Klinika, Semmelweis Egyetem, Budapest, Hungary. ggalffy@hotmail.com
authors.forename: Gabriella
authors.initials: G
authors.lastname: Gálffy
mesh_terms: D000740:Anemia / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D018288:Carcinoma, Small Cell / Q000188:drug therapy; D018450:Disease Progression; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism*; D017707:Erythrocyte Transfusion / Q000009:adverse effects / Q000592:standards; D004921:Erythropoietin / Q000008:administration & dosage / Q000009:adverse effects / Q000819:agonists*; D006397:Hematinics / Q000008:administration & dosage* / Q000009:adverse effects*; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D011788:Quality of Life; D017467:Receptors, Erythropoietin / Q000187:drug effects / Q000378:metabolism*; D012720:Severity of Illness Index; D054556:Venous Thromboembolism / Q000139:chemically induced
chemical_list: D006397:Hematinics; D006454:Hemoglobins; D017467:Receptors, Erythropoietin; D004921:Erythropoietin