title: Statin therapy does not improve lung function in asthma: a meta-analysis of randomized controlled trials.
abstract: OBJECTIVE
  To assess the efficacy of statins in the treatment of asthma.
  
  
  METHODS
  Electronic databases were searched to identify randomized controlled trials that measured the efficacy of statins in the treatment of asthma, and a meta-analysis of the pooled data was performed.
  
  
  RESULTS
  Five trials were identified; four met the inclusion criteria (total number of patients 200). Compared with controls, patients in the statin groups had higher forced expiratory volume in 1 s (FEV1) values before inhaled corticosteroids (0.09 l, 95% confidence interval [CI] -0.06, 0.23), higher FEV1 values after inhaled corticosteroids (0.06 l, 95% CI -0.09, 0.22), and higher morning peak expiratory flow rates (9.87 l, 95% CI -15.66, 35.40). These results were not statistically significant and, furthermore, publication bias was detected.
  
  
  CONCLUSIONS
  In conclusion, there is currently insufficient evidence to show that statins improve lung function in patients with asthma.
authors.affiliation: Department of Cardiology, Beijing Hospital of the Ministry of Public Health, Beijing, China.
authors.forename: Xiao-bei
authors.initials: XB
authors.lastname: Si
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhang
authors.forename: Lin-yu
authors.initials: LY
authors.lastname: Huo
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Dai
authors.forename: Hai-long
authors.initials: HL
authors.lastname: Wang
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology*; D016022:Case-Control Studies; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D016032:Randomized Controlled Trials as Topic
chemical_list: D000305:Adrenal Cortex Hormones; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Asthma; lung function; meta-analysis; statins