title: Phase I trial in oncology--theory and practice.
abstract: Phase I trials in oncology usually enrolling patients with advanced disease who have failed standard treatment options. The primary endpoint of these studies is to establish the recommended dose and/or schedule of new drugs or drug combinations for phase II trials. The guiding principle for dose escalation in phase I trials is to avoid unnecessary exposure of patients to sub-therapeutic doses of an agent. The mission of phase I clinical trials is to accelerate the development of new anticancer drugs with the purpose of improving quality of life and survival for patients with cancer.
authors.affiliation: Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
authors.forename: R
authors.initials: R
authors.lastname: Demlova
authors.forename: R
authors.initials: R
authors.lastname: Obermannova
authors.forename: D
authors.initials: D
authors.lastname: Valik
authors.forename: R
authors.initials: R
authors.lastname: Vyzula
mesh_terms: D017321:Clinical Trials, Phase I as Topic; D006801:Humans; D008495:Medical Oncology