title: [Elevation of Ca 125 in a patient with giant congenital hydronephrosis].
abstract: OBJECTIVE
  To report a new case with elevation of Ca 125 and hydronephrotic kidney without neoplastic disease, having special reference to clinical aspects.
  
  
  METHODS
  The clinical history, anatomopathological and immunohistochemical findings are described. We performed a bibliographic review. We report the case of a 27 year-old female with the diagnosis of giant hydronephrosis and Ca125 elevation (313 u/ml hydronephrotic kidney urine and 112.3 u/ml serum).
  
  
  RESULTS
  She underwent a radical nephrectomy and Ca125 levels decreased. After 9 years the patient did not have any neoplastic disease and Ca125 levels are normal.
  
  
  CONCLUSIONS
  The Ca125 rise with hydronephrotic kidney may be usual although there are not enough studies. We think that in patients with hydronephrotic kidney and malignant neoplasm the Ca125 antigen can lose sensitivity for the early diagnosis, staging and follow up of the malignant diseases.
authors.affiliation: Urology Department, Hospital Juan Ramon Jimenez Huelva, Huelva, Spain. rafakm.uro@gmail.com
authors.forename: Rafael
authors.initials: R
authors.lastname: El Khoury Moreno
authors.forename: Juan Francisco
authors.initials: JF
authors.lastname: Dominguez Molinero
authors.forename: Jose Pedro
authors.initials: JP
authors.lastname: Rodríguez Rincón
authors.forename: Pedro
authors.initials: P
authors.lastname: Coterón Ochoa
authors.forename: Patricia
authors.initials: P
authors.lastname: Coronil Belloso
authors.forename: Manuel
authors.initials: M
authors.lastname: Gómez Velázquez
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen / Q000032:analysis*; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000151:congenital* / Q000473:pathology*; D007680:Kidney Neoplasms / Q000473:pathology*; D009392:Nephrectomy; D019459:Urothelium / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D004815:Epidermal Growth Factor