title: Review on natural coumarin lead compounds for their pharmacological activity.
abstract: Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective properties. Dietary exposure to benzopyrones is significant as these compounds are found in vegetables, fruits, seeds, nuts, coffee, tea, and wine. In view of the established low toxicity, relative cheapness, presence in the diet, and occurrence in various herbal remedies of coumarins, it appears prudent to evaluate their properties and applications further.
authors.affiliation: Department of Biotechnology and Food Technology, Durban University of Technology, Durban 4001, South Africa.
authors.forename: K N
authors.initials: KN
authors.lastname: Venugopala
authors.forename: V
authors.initials: V
authors.lastname: Rashmi
authors.forename: B
authors.initials: B
authors.lastname: Odhav
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use; D000925:Anticoagulants / Q000737:chemistry / Q000627:therapeutic use; D000935:Antifungal Agents / Q000737:chemistry / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000737:chemistry / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D000998:Antiviral Agents / Q000737:chemistry / Q000627:therapeutic use; D003374:Coumarins / Q000009:adverse effects / Q000737:chemistry* / Q000145:classification* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D000935:Antifungal Agents; D000959:Antihypertensive Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D003374:Coumarins