title: Going beyond antidepressant monotherapy for incomplete response in nonpsychotic late-life depression: a critical review.
abstract: Many older adults with major depressive disorder (MDD) do not respond to antidepressant monotherapy. Although there are evidence-based treatment options to support treatment beyond monotherapy for adults, the evidence for such strategies, specifically in late-life MDD, is relatively scarce. This review examines the published data describing strategies for antidepressant augmentation or acceleration studied specifically in older adults, including lithium, stimulants, and second-generation antipsychotics. In addition, the authors suggest strategies for future research, such as study of specific agents, refining understanding of the impact of medical or cognitive comorbidity in late-life depression, and comparative effectiveness to examine methods already used in clinical practice.
authors.affiliation: Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address: Donovan.Maust@uphs.upenn.edu.
authors.forename: Donovan T
authors.initials: DT
authors.lastname: Maust
authors.forename: David W
authors.initials: DW
authors.lastname: Oslin
authors.forename: Michael E
authors.initials: ME
authors.lastname: Thase
mesh_terms: D000375:Aging / Q000187:drug effects / Q000523:psychology*; D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D018020:Lithium Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D012074:Remission Induction
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D018020:Lithium Compounds
keywords: Antidepressant; augmentation; depression; pharmacotherapy