title: Using space-based investigations to inform cancer research on Earth.
abstract: Experiments conducted in the microgravity environment of space are not typically at the forefront of the mind of a cancer biologist. However, space provides physical conditions that are not achievable on Earth, as well as conditions that can be exploited to study mechanisms and pathways that control cell growth and function. Over the past four decades, studies have shown how exposure to microgravity alters biological processes that may be relevant to cancer. In this Review, we explore the influence of microgravity on cell biology, focusing on tumour cells grown in space together with work carried out using models in ground-based investigations.
authors.affiliation: Nano3D Biosciences, Houston, TX 77030, USA. jbecker@n3dbio.com
authors.forename: Jeanne L
authors.initials: JL
authors.lastname: Becker
authors.forename: Glauco R
authors.initials: GR
authors.lastname: Souza
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D018929:Cell Culture Techniques / Q000379:methods; D018920:Coculture Techniques; D004339:Drug Compounding; D006801:Humans; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D010789:Phototherapy; D018531:Spacecraft; D014893:Weightlessness
chemical_list: D000970:Antineoplastic Agents