title: P-arylation: arynes to aryl-phosphonates, -phosphinates, and -phosphine oxides.
abstract: Synthesis of organo-phosphorus compounds and their application in organic synthesis and life sciences has been a topic of contemporary interest. Michaelis-Arbuzov reaction is the most extensively utilized method for their preparation, which works well only with aliphatic halides. Hence, relatively harsh reaction conditions using transition-metal-catalyzed P-arylation (Arbuzov/Hirao reaction) are used for the preparation of aryl-phosphorus compounds. Presented herein is a competent process for the synthesis of aryl-phosphonates, -phosphinates, and -phosphine oxides by making an efficient use of arynes for C-P bond construction.
authors.affiliation: Division of Organic Chemistry, National Chemical Laboratory (CSIR-NCL), Pune 411008, India.
authors.forename: Ranjeet A
authors.initials: RA
authors.lastname: Dhokale
authors.forename: Santosh B
authors.initials: SB
authors.lastname: Mhaske
mesh_terms: D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010087:Oxides / Q000737:chemistry; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006219:Halogens; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D010087:Oxides; D010720:Phosphines; C044646:phosphine