title: Protective effect of periplaneta americana extract on intestinal mucosal barrier function in patients with sepsis.
abstract: OBJECTIVE
  To investigate the effect of the periplaneta americana extract on the intestinal mucosal barrier and prognostic implications in patients with sepsis.
  
  
  METHODS
  Sixty and six patients with sepsis were assigned randomly to treatment group (32 cases) and control group (32 cases). The extractfrom periplaneta americana plus conventional medication for sepsis was administered to the treatment group, while the control group only received conventional treatment. The gastrointestinal function scores and acute physiology and chronic health evaluation II (APACHE II) scores of all subjects were documented at baseline, at days 1, 3 and 7 after treatment respectively and their blood endotoxin was tested at the same time points as well. The incidence of death was recorded for both groups throughout the trial.
  
  
  RESULTS
  At days 3 and 7 after treatment, gastrointestinal function score, APACHE II, and endotoxin level in treatment group was better than that in control group and the difference between them was significant (both P < 0.05). Although the incidence of death in treatment group was less than that in control group, the difference between the two groups was not significant (P > 0.05).
  
  
  CONCLUSIONS
  The extract of periplaneta americana had protective effect on intestinal mucosal barrier and could improve the condition and prognosis in patients with sepsis.
authors.affiliation: Department of Intensive Care Unit, The Second Hospital of Tangshan, Tangshan 063000, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhang
authors.forename: Liyou
authors.initials: L
authors.lastname: Wei
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhang
authors.forename: Shuzheng
authors.initials: S
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Yanling
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001685:Biological Factors / Q000008:administration & dosage* / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010526:Periplaneta / Q000737:chemistry*; D020011:Protective Agents / Q000008:administration & dosage* / Q000302:isolation & purification; D018805:Sepsis / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology / Q000517:prevention & control; D055815:Young Adult
chemical_list: D001685:Biological Factors; D020011:Protective Agents