title: The role of nodose ganglia in the regulation of cardiovascular function following pulmonary exposure to ultrafine titanium dioxide.
abstract: The inhalation of nanosized air pollutant particles is a recognised risk factor for cardiovascular disease; however, the link between occupational exposure to engineered nanoparticles and adverse cardiovascular events remains unclear. In the present study, the authors demonstrated that pulmonary exposure of rats to ultrafine titanium dioxide (UFTiO2) significantly increased heart rate and depressed diastolic function of the heart in response to isoproterenol. Moreover, pulmonary inhalation of UFTiO2 elevated mean and diastolic blood pressure in response to norepinephrine. Pretreatment of the rats ip with the transient receptor potential (TRP) channel blocker ruthenium red inhibited substance P synthesis in nodose ganglia and associated functional and biological changes in the cardiovascular system. In conclusion, the effects of pulmonary inhalation of UFTiO2 on cardiovascular function are most likely triggered by a lung-nodose ganglia-regulated pathway via the activation of TRP channels in the lung.
authors.affiliation: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, PPRB , Morgantown, WV , USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Kan
authors.forename: Zhongxin
authors.initials: Z
authors.lastname: Wu
authors.forename: Yen-Chang
authors.initials: YC
authors.lastname: Lin
authors.forename: Teh-Hsun
authors.initials: TH
authors.lastname: Chen
authors.forename: Jared L
authors.initials: JL
authors.lastname: Cumpston
authors.forename: Michael L
authors.initials: ML
authors.lastname: Kashon
authors.forename: Steve
authors.initials: S
authors.lastname: Leonard
authors.forename: Albert E
authors.initials: AE
authors.lastname: Munson
authors.forename: Vincent
authors.initials: V
authors.lastname: Castranova
mesh_terms: D000280:Administration, Inhalation; D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005727:Ganglia, Spinal / Q000737:chemistry / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000737:chemistry; D032383:Myocytes, Cardiac / Q000737:chemistry; D009620:Nodose Ganglion / Q000737:chemistry / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000032:analysis; D013373:Substance P / Q000032:analysis; D014025:Titanium / Q000008:administration & dosage / Q000633:toxicity*; D019210:Troponin I / Q000032:analysis / Q000737:chemistry; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D017382:Reactive Oxygen Species; D019210:Troponin I; C009495:titanium dioxide; D013373:Substance P; D014025:Titanium