title: Results of 226 patients with T3 laryngeal carcinoma after treatment with transoral laser microsurgery.
abstract: BACKGROUND
  The purpose of this study was to assess the feasibility of transoral laser microsurgery (TLM) in treatment of pT3 laryngeal cancer.
  
  
  METHODS
  We conducted a retrospective case series study of 226 patients with pT3 glottic (n = 122; 54%) or supraglottic laryngeal carcinoma (n = 104; 46%). All patients were treated by TLM in combination with neck dissection (63%) and with postoperative radiotherapy (18%). Our main outcome measures were local control, organ preservation, functional outcome, overall survival, recurrence-free survival, and disease-specific survival.
  
  
  RESULTS
  Median follow-up period was 57.8 months. The 5-year organ-preservation and local control rates for all patients were 87% and 71.4%, respectively. The 5-year overall, recurrence-free, and disease-specific survival were 64.4%, 63.0%, and 83.3%, respectively.
  
  
  CONCLUSIONS
  Results are comparable to partial or total laryngectomy, while being superior to primary chemo(radio)therapy. TLM results in low morbidity, rapid recovery, and good function and can be a valid option for organ-preserving surgery of pT3 glottic and supraglottic cancer.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Göttingen, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Canis
authors.forename: Friedrich
authors.initials: F
authors.lastname: Ihler
authors.forename: Alexios
authors.initials: A
authors.lastname: Martin
authors.forename: Hendrik A
authors.initials: HA
authors.lastname: Wolff
authors.forename: Christoph
authors.initials: C
authors.lastname: Matthias
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Steiner
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D059248:Chemoradiotherapy / Q000379:methods*; D018572:Disease-Free Survival; D005240:Feasibility Studies; D005260:Female; D005931:Glottis / Q000473:pathology / Q000601:surgery; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D007825:Laryngectomy / Q000379:methods; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008866:Microsurgery / Q000379:methods; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods / Q000401:mortality; D037981:Neck Dissection / Q000379:methods; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D059351:Organ Sparing Treatments; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D016896:Treatment Outcome
keywords: T3 laryngeal carcinoma; functional outcomes; oncologic results; organ preservation; transoral laser microsurgery