title: [Lung metastasectomy for postoperative colorectal cancer in patients with a history of hepatic metastasis].
abstract: OBJECTIVE
  Our objective was to evaluate the validity of pulmonary metastasectomy for postoperative colorectal cancer with hepatic metastasis and to investigate the role of clinicopathological factors as predictors of outcome.
  
  
  METHODS
  Consecutive patients undergoing pulmonary metastasectomy for colorectal cancer with (group PH, n=27) or without (group P, n=46) a history of hepatic metastasis were included in the study. Clinicopathological variables, including sex, age, site, serum carcinoembryonic antigen level of the primary tumor, disease-free interval, prior hepatic resection, timing of pulmonary metastases, preoperative chemotherapy, type of pulmonary resection, and number, size, and location of pulmonary metastases were retrospectively collected and investigated for prognostic significance.
  
  
  RESULTS
  The 5-year survivals were 59.5% (PH) and 70.0% (P) with no significant difference. Among all investigated prognostic variables, sex (female vs male) and the number of pulmonary metastases( 1 vs >1) were the most important factors affecting outcome after colorectal resection and pulmonary resection.
  
  
  CONCLUSIONS
  Pulmonary resection is not contraindicated in clinical practice. The presence of female gender and a single pulmonary metastasis were favorable predictors of survival after complete pulmonary resection for metastatic colorectal cancer.
authors.affiliation: Department of General Thoracic Surgery, Maebashi Red Cross Hospital, Maebashi, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kamiyoshihara
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Igai
authors.forename: Takashi
authors.initials: T
authors.lastname: Ibe
authors.forename: Natsuko
authors.initials: N
authors.lastname: Kawatani
authors.forename: Tatemasa
authors.initials: T
authors.lastname: Ando
authors.forename: Naoki
authors.initials: N
authors.lastname: Tomizawa
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ohtaki
authors.forename: Jun
authors.initials: J
authors.lastname: Atsumi
authors.forename: Seshiru
authors.initials: S
authors.lastname: Nakazawa
authors.forename: Kai
authors.initials: K
authors.lastname: Obayashi
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Shimizu
authors.forename: Izumi
authors.initials: I
authors.lastname: Takeyoshi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D008168:Lung / Q000601:surgery*; D008175:Lung Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D059146:Metastasectomy; D008875:Middle Aged; D011013:Pneumonectomy