title: Aggressive adenocarcinoma of the lung consisting solely of discohesive cells.
abstract: A 60-year-old Japanese man was found to have diffuse pneumonia-like shadow in the left S10 segment on chest computed tomographic scan. Transbronchial lung biopsy yielded a pathological diagnosis of poorly differentiated adenocarcinoma; subsequently, left lower lobectomy was performed. Histopathological analysis showed that the tumor consisted solely of discohesive cells with involvement of the hilar and mediastinal lymph nodes. The immunohistochemical expression of E-cadherin and β-catenin was low, whereas that of p53 was high in the tumor cells. Here, we describe a rare lung adenocarcinoma with discohesive cells, which are considered to indicate high tumor aggressiveness.
authors.affiliation: Division of Thoracic Surgery, Shizuoka Cancer Center, Shizuoka 411-8777, Japan. y.kozu@scchr.jp
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kozu
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Isaka
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Ohde
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakajima
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D000077192:Adenocarcinoma of Lung; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008168:Lung / Q000166:cytology / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008198:Lymph Nodes / Q000166:cytology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000175:diagnosis / Q000473:pathology