title: Integrative avenues for exploring the dynamics and evolution of protein interaction networks.
abstract: Over the past decade, the study of protein interaction networks (PINs) has shed light on the organizing principles of living cells. However, PINs have been mostly mapped in one single condition. We outline three of the most promising avenues of investigation in this field, namely the study of first, how PINs are rewired by mutations and environmental perturbations; secondly, how inter-species interactions affect PIN achitectures; thirdly, what mechanisms and forces drive PIN evolution. These investigations will unravel the dynamics and condition dependence of PINs and will thus lead to a better functional annotation of network architecture. One major challenge to reach these goals is the integration of PINs with other cellular regulatory networks in the context of complex cellular phenotypes.
authors.affiliation: Département de Biologie, Institut de Biologie Intégrative et des Systèmes (IBIS), PROTEO, Université Laval, Québec, Canada G1V 0A6.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Diss
authors.forename: Marie
authors.initials: M
authors.lastname: Filteau
authors.forename: Luca
authors.initials: L
authors.lastname: Freschi
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Leducq
authors.forename: Samuel
authors.initials: S
authors.lastname: Rochette
authors.forename: Francisco
authors.initials: F
authors.lastname: Torres-Quiroz
authors.forename: Christian R
authors.initials: CR
authors.lastname: Landry
mesh_terms: D000818:Animals; D005075:Biological Evolution; D005786:Gene Expression Regulation; D006801:Humans; D060066:Protein Interaction Maps; D020543:Proteome / Q000378:metabolism
chemical_list: D020543:Proteome