title: Nanovacuums: nanoparticle uptake and differential cellular migration on a carpet of nanoparticles.
abstract: The behavior of prostate carcinoma (PC3) cells and human dermal fibroblast (HDF) cells when incubated with sedimented Au NPs in vitro is studied. Darkfield microscopy demonstrates that both PC3 and HDF cells can "vacuum" Au NPs from the surface. Mean square displacement and mean cumulative square distance of cells shows that PC3 migration decreases in the presence of Au NPs while for HDF, migration is dependent on the surface charge and shape of Au NPs.
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA.
authors.forename: Jie An
authors.initials: JA
authors.lastname: Yang
authors.forename: Hoa Tri
authors.initials: HT
authors.lastname: Phan
authors.forename: Shruti
authors.initials: S
authors.lastname: Vaidya
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Murphy
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement; D005347:Fibroblasts / Q000737:chemistry* / Q000166:cytology; D006046:Gold / Q000737:chemistry / Q000493:pharmacokinetics*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D006046:Gold