title: Lack of correlation between the resistances to two rhabdovirus infections in rainbow trout.
abstract: The Viral Hemorrhagic Septicemia Virus (VHSV) and the Infectious Hematopoietic Necrosis Virus (IHNV) are two rhabdoviruses responsible for serious outbreaks in salmonid farms. To date, little is known about the variability of host response to these viruses. Using gynogenetic clonal lines of rainbow trout exhibiting a wide range of resistance to viral infections, we showed that there was no correlation between the resistance to VHSV and IHNV. We also confirmed the importance of fish weight for its susceptibility to IHNV infection. Finally, using a chimeric recombinant IHNV expressing the VHSV glycoprotein, we showed that the glycoprotein plays a key role in the virulence and in the level of resistance observed in different genetic backgrounds. Taken together, our results provide new prospects for a better understanding of host responses to rhabdovirus infections in salmonids.
authors.affiliation: INRA, UMR 1313 Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France.
authors.forename: Eloi R
authors.initials: ER
authors.lastname: Verrier
authors.forename: Aude
authors.initials: A
authors.lastname: Ehanno
authors.forename: Stéphane
authors.initials: S
authors.lastname: Biacchesi
authors.forename: Sandrine
authors.initials: S
authors.lastname: Le Guillou
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dechamp
authors.forename: Pierre
authors.initials: P
authors.lastname: Boudinot
authors.forename: Michel
authors.initials: M
authors.lastname: Bremont
authors.forename: Edwige
authors.initials: E
authors.lastname: Quillet
mesh_terms: D000818:Animals; D001835:Body Weight; D060467:Disease Resistance; D005393:Fish Diseases / Q000235:genetics / Q000276:immunology* / Q000821:virology*; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism; D029142:Infectious hematopoietic necrosis virus / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D029141:Novirhabdovirus / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D017686:Oncorhynchus mykiss; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D018353:Rhabdoviridae Infections / Q000235:genetics / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D014774:Virulence
chemical_list: D006023:Glycoproteins; D011994:Recombinant Proteins; D014764:Viral Proteins