title: Depth of glandular crypts and its involvement in squamous intraepithelial cervical neoplasia submitted to large loop excision of transformation zone (LLETZ).
abstract: BACKGROUND
  The authors aimed to confirm the depth of six mm in order to achieve an optimal eradication of the lesion.
  
  
  METHODS
  This is a retrospective observational study of 94 cervical surgical pieces from women aged 17 to 22 years with a cyto-colpo-histopathological diagnosis of high-grade squamous cervical intraepithelial neoplasia (CIN II and/or CIN III) submitted to large loop excision of transformation zone (LLETZ). The glandular crypts and margins, both exposed or not to CIN, were assessed. The compromise and the maximum depth of the glandular crypts were noticed.
  
  
  RESULTS
  After LLETZ, 23 (24.47%) cases presented a neoplasic impairment of endocervical margin and ten (10.64%) of the ectocervical margin. The largest noticed crypt measured 4.500 mm and the shortest 0.100 mm, with an average of 2.148 mm.
  
  
  CONCLUSIONS
  Squamous CIN more frequently show the exposure of surgical margins to LLETZ. The deeper location of glandular crypts in the cases studied was 4.500 mm, while the largest neoplastic extension was 3.000 mm.The therapeutic method depends on this knowledge.
authors.affiliation: Gynaecological Disease Prevention Center, General Gynaecology Discipline, Gynaecology Department Escola Paulista de Medicina EPM, Federal University of São Paulo--UNIFESP, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Okazaki
authors.forename: G R A
authors.initials: GR
authors.lastname: Focchi
authors.forename: N S A
authors.initials: NS
authors.lastname: Taha
authors.forename: P Q
authors.initials: PQ
authors.lastname: Almeida
authors.forename: M A
authors.initials: MA
authors.lastname: Schimidt
authors.forename: N M G
authors.initials: NM
authors.lastname: Speck
authors.forename: J C L
authors.initials: JC
authors.lastname: Ribalta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*