title: A conjugated polymer-peptide hybrid system for prostate-specific antigen (PSA) detection.
abstract: We developed fast and readily applicable microarray chips to detect PSA by designing a novel conjugated polymer (energy donor) and combining it with on-chip peptide synthesis. The selective cleavage of a probing peptide labelled with a dye or a quencher (energy acceptor) produced a fluorescence sensory signal via fluorescent energy resonance transfer (FRET).
authors.affiliation: Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Kangwon
authors.initials: K
authors.lastname: Lee
authors.forename: Suparna
authors.initials: S
authors.lastname: Mandal
authors.forename: Jinga
authors.initials: J
authors.lastname: Morry
authors.forename: Onnop
authors.initials: O
authors.lastname: Srivannavit
authors.forename: Erdogan
authors.initials: E
authors.lastname: Gulari
authors.forename: Jinsang
authors.initials: J
authors.lastname: Kim
mesh_terms: D005453:Fluorescence; D031541:Fluorescence Resonance Energy Transfer; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D017430:Prostate-Specific Antigen / Q000032:analysis*; D040081:Protein Array Analysis; D013050:Spectrometry, Fluorescence
chemical_list: D010455:Peptides; D011108:Polymers; D017430:Prostate-Specific Antigen