title: Shedding new light on circadian clocks.
abstract: Using a clever combination of genetic and biochemical tools researchers have shown that a transcription factor called USF1 has a central role in determining how mutations of the Clock gene manifest themselves in the behaviour of different mouse strains.
authors.affiliation: is at the Department of Molecular Biology , University of Geneva , Geneva , Switzerland maud.demarque@unige.ch.
authors.forename: Maud
authors.initials: M
authors.lastname: Demarque
authors.forename: Ueli
authors.initials: U
authors.lastname: Schibler
mesh_terms: D056930:ARNTL Transcription Factors / Q000378:metabolism*; D000818:Animals; D056926:CLOCK Proteins / Q000378:metabolism*; D057906:Circadian Clocks; D002940:Circadian Rhythm; D004247:DNA / Q000378:metabolism*; D009154:Mutation; D051720:Upstream Stimulatory Factors / Q000378:metabolism*
chemical_list: D056930:ARNTL Transcription Factors; C538961:Bmal1 protein, mouse; D051720:Upstream Stimulatory Factors; C497183:Usf1 protein, mouse; D004247:DNA; D056926:CLOCK Proteins; C538944:Clock protein, mouse
keywords: ChIP-Seq; Clock gene; Mouse; USF1; circadian rhythms; genetic modifier; mouse genetics