title: Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders.
abstract: The morbidity of ocular diseases, including macular degeneration, diabetic retinopathy, and dry eye disease, has been gradually increasing worldwide. Because these diseases develop from age-associated ocular dysfunctions, interventions against the aging process itself may be a promising strategy for their management. Among the several approaches to interrupt aging processes, calorie restriction (CR) has been shown to recover and/or slow age-related functional declines in various organs, including the eye. Here, we review interventions against the aging process as potential therapeutic approaches to age-related ocular diseases. The effects of CR and CR mimetics in animal models of age-related eye diseases are explored. Furthermore, we discuss the possibilities of expanding this research to prospective studies to elucidate the molecular mechanisms by which CR and/or CR mimetics preserve ocular functions.
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Motoko
authors.initials: M
authors.lastname: Kawashima
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ozawa
authors.forename: Ken
authors.initials: K
authors.lastname: Shinmura
authors.forename: Takaaki
authors.initials: T
authors.lastname: Inaba
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nakamura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kawakita
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D031204:Caloric Restriction / Q000379:methods*; D004195:Disease Models, Animal; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage; D005128:Eye Diseases / Q000178:diet therapy / Q000517:prevention & control*; D005544:Forecasting; D006801:Humans; D007781:Lactoferrin / Q000008:administration & dosage; D014975:Lutein / Q000008:administration & dosage; D051379:Mice; D018345:Mice, Knockout; D059808:Polyphenols / Q000008:administration & dosage; D051381:Rats
chemical_list: D000975:Antioxidants; D059808:Polyphenols; D015118:Eicosapentaenoic Acid; D007781:Lactoferrin; D014975:Lutein
keywords: Calorie restriction; Calorie restriction mimetics; Cataract; Dry eye; Retinal disease