title: Protease genotypes in patients failing protease inhibitor-based antiretroviral therapy at a pediatric center in Botswana.
abstract: With increasing use of protease inhibitors (PI) in Botswana, a large proportion of HIV-infected children are now exposed to PI-based regimens. There is limited protease genotype data from African children and adolescents who have failed PI-based antiretroviral therapy. We describe a cohort of pediatric HIV-infected patients experiencing virologic failure at time of second-line or salvage PI-based regimens and analyze associated PI mutations.
authors.affiliation: From the Botswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana, and Baylor College of Medicine, Houston, TX.
authors.forename: Andres
authors.initials: A
authors.lastname: Gomila
authors.forename: Brianna
authors.initials: B
authors.lastname: Kirk
authors.forename: Marape
authors.initials: M
authors.lastname: Marape
authors.forename: Gabriel
authors.initials: G
authors.lastname: Anabwani
authors.forename: Michael
authors.initials: M
authors.lastname: Tolle
mesh_terms: D000293:Adolescent; D001902:Botswana; D002648:Child; D002675:Child, Preschool; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D016333:HIV Protease / Q000235:genetics*; D015497:HIV-1 / Q000201:enzymology* / Q000235:genetics*; D006801:Humans; D009154:Mutation; D011480:Protease Inhibitors / Q000627:therapeutic use*; D012189:Retrospective Studies; D017211:Treatment Failure
chemical_list: D011480:Protease Inhibitors; D016333:HIV Protease