title: 25-OH-Vitamin D and procalcitonin levels after correction of acute hyperglycemia.
abstract: BACKGROUND
  Hyperglycemia is a common complication of diabetes melitis (DM) and in the absence of metabolic decompensation is a common finding in the Emergency Department (ED). We aimed to evaluate the 25 OH Vit D [25(OH)D] and procalcitonin (PCT) levels during hyperglycemia and after normalization of blood glucose.
  
  
  METHODS
  The study included 88 patients over the age of 18 years who presented with acute hyperglycemia at the Hacettepe University Department of Emergency Medicine. Euglycemia was obtained within 6-12 hours and serum samples were taken from patients on admission and 6 hours after normalization of blood glucose. Along with plasma glucose, plasma 25(OH)D and PCT levels were measured using ELISA.
  
  
  RESULTS
  There were 88 (45 males) patients, with a median age of 60.0±13.9 years. Serum 25(OH)D levels increased in all patients after normalization of blood glucose, and serum PCT levels decreased in the whole group. This decrease was independent of type of diabetes or presence of infection.
  
  
  CONCLUSIONS
  We demonstrated an increase in 25(OH)D after normalization of blood glucose, and a decrease in PCT in patients with hyperglycemia. This effect was independent of the type of diabetes and presence of infection. Further studies are needed to evaluate the faster link between metabolic abnormalities, vitamin D, PCT, and inflammation.
authors.affiliation: Hacettepe University, Department of Emergency Medicine, Ankara, Turkey. nmaksu@superposta.com
authors.forename: Nalan Metin
authors.initials: NM
authors.lastname: Aksu
authors.forename: Duygu Yazgan
authors.initials: DY
authors.lastname: Aksoy
authors.forename: Meltem
authors.initials: M
authors.lastname: Akkaş
authors.forename: Hakkı
authors.initials: H
authors.lastname: Yilmaz
authors.forename: Canan
authors.initials: C
authors.lastname: Akman
authors.forename: Bülent Okan
authors.initials: BO
authors.lastname: Yildiz
authors.forename: Mahir M
authors.initials: MM
authors.lastname: Ozmen
authors.forename: Aydan
authors.initials: A
authors.lastname: Usman
mesh_terms: D000208:Acute Disease; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000188:drug therapy*; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: C000606589:CALCA protein, human; D007328:Insulin; D011498:Protein Precursors; D014807:Vitamin D; D002116:Calcitonin; C104450:25-hydroxyvitamin D; D015740:Calcitonin Gene-Related Peptide