title: [Intraoperative chemotherapy after radical pleurectomy or extrapleural pneumonectomy].
abstract: Trimodality treatment including induction and/or adjuvant chemotherapy, surgical resection and in some cases radiotherapy offers a curative intention in selected patients with pleural malignancies (malignant pleural mesothelioma, thymoma with pleural spread). Nevertheless, locoregional tumor recurrence mainly limits the outcome and the quality of life. A few years ago an additional intraoperative chemotherapy perfusion was developed in order to improve local tumor control and prognosis after surgical resection in a multimodality treatment setting. Cytoreductive surgery with the purpose of a macroscopic complete resection could be achieved by radical pleurectomy or extrapleural pneumonectomy. The concept, techniques and perioperative management of this additional treatment option are presented along with a detailed review of the recent literature.
authors.affiliation: Abteilung für Thoraxchirurgie, Universitätsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Deutschland. micha.ried@t-online.de
authors.forename: M
authors.initials: M
authors.lastname: Ried
authors.forename: H-S
authors.initials: HS
authors.lastname: Hofmann
mesh_terms: D017024:Chemotherapy, Adjuvant; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D003422:Critical Care / Q000379:methods; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007432:Intraoperative Period; D010994:Pleura / Q000473:pathology / Q000601:surgery*; D010997:Pleural Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D011013:Pneumonectomy / Q000379:methods*; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D015996:Survival Rate; D013945:Thymoma / Q000188:drug therapy / Q000473:pathology / Q000556:secondary / Q000601:surgery; D013953:Thymus Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery
chemical_list: D002945:Cisplatin