title: 5-Oxo-ETE receptor antagonists.
abstract: 5-Oxo-ETE is the most powerful eosinophil chemoattractant among lipid mediators. Eosinophil infiltration into the lungs of asthmatics may be responsible for the late phase of inflammatory asthma. We have designed and synthesized a 5-oxo-ETE receptor antagonist, the purpose of which is to prevent eosinophil migration to the lung during an asthma attack and thereby reduce asthma symptoms.
authors.affiliation: Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 West University Boulevard, Melbourne, Florida 32901, United States.
authors.forename: Vivek
authors.initials: V
authors.lastname: Gore
authors.forename: Pranav
authors.initials: P
authors.lastname: Patel
authors.forename: Chih-Tsung
authors.initials: CT
authors.lastname: Chang
authors.forename: Sashikala
authors.initials: S
authors.lastname: Sivendran
authors.forename: Namin
authors.initials: N
authors.lastname: Kang
authors.forename: Yannick P
authors.initials: YP
authors.lastname: Ouedraogo
authors.forename: Sylvie
authors.initials: S
authors.lastname: Gravel
authors.forename: William S
authors.initials: WS
authors.lastname: Powell
authors.forename: Joshua
authors.initials: J
authors.lastname: Rokach
mesh_terms: D001095:Arachidonic Acids / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D018055:Receptors, Eicosanoid / Q000037:antagonists & inhibitors*
chemical_list: D001095:Arachidonic Acids; D007211:Indoles; D018055:Receptors, Eicosanoid; C080828:5-oxo-6,8,11,14-eicosatetraenoic acid