title: A review of numerical methods for red blood cell flow simulation.
abstract: In this review, we provide an overview of the simulation techniques employed for modelling the flow of red blood cells (RBCs) in blood plasma. The scope of this review omits the fluid modelling aspect while focusing on other key components in the RBC-plasma model such as (1) describing the RBC deformation with shell-based and spring-based RBC models, (2) constitutive models for RBC aggregation based on bridging theory and depletion theory and (3) additional strategies required for completing the RBC-plasma flow model. These include topics such as modelling fluid-structure interaction with the immersed boundary method and boundary integral method, and updating the variations in multiphase fluid property through the employment of index field methods. Lastly, we summarily discuss the current state and aims of RBC modelling and suggest some research directions for the further development of this field of modelling.
authors.affiliation: a Department of Bioengineering , National University of Singapore , Singapore.
authors.forename: Meongkeun
authors.initials: M
authors.lastname: Ju
authors.forename: Swe Soe
authors.initials: SS
authors.lastname: Ye
authors.forename: Bumseok
authors.initials: B
authors.lastname: Namgung
authors.forename: Seungkwan
authors.initials: S
authors.lastname: Cho
authors.forename: Hong Tong
authors.initials: HT
authors.lastname: Low
authors.forename: Hwa Liang
authors.initials: HL
authors.lastname: Leo
authors.forename: Sangho
authors.initials: S
authors.lastname: Kim
mesh_terms: D003198:Computer Simulation; D004907:Erythrocyte Deformability; D004910:Erythrocyte Membrane / Q000502:physiology; D004912:Erythrocytes / Q000166:cytology / Q000502:physiology*; D018056:Hemorheology / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted
keywords: RBC aggregation modelling; RBC deformation modelling; blood rheology; haemodynamics