title: An ocular view of the IGF-IGFBP system.
abstract: IGFs and their binding proteins have been shown to exhibit both protective and deleterious effects in ocular disease. Recent studies have characterized the expression patterns of different IGFBPs in retinal layers and within the vitreous. IGFBP-3 has roles in vascular protection stimulating proliferation, migration, and differentiation of vascular progenitor cells to sites of injury. IGFBP-3 increases pericyte ensheathment and shows anti-inflammatory effects by reducing microglia activation in diabetes. IGFBP-5 has recently been linked to mediating fibrosis in proliferative vitreoretinopathy but also reduces neovascularization. Thus, the regulatory balance between IGF and IGFBPs can have profound impact on target tissues. This review discusses recent findings of IGF and IGFBP expression in the eye with relevance to different retinopathies.
authors.affiliation: Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Dung V
authors.initials: DV
authors.lastname: Nguyen
authors.forename: Sergio
authors.initials: S
authors.lastname: Li Calzi
authors.forename: Lynn C
authors.initials: LC
authors.lastname: Shaw
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Kielczewski
authors.forename: Hannah E
authors.initials: HE
authors.lastname: Korah
authors.forename: Maria B
authors.initials: MB
authors.lastname: Grant
mesh_terms: D000818:Animals; D005128:Eye Diseases / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*
chemical_list: D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I