title: [Accidental shortening time of high dose methotrexate infusion: case report and literature review].
abstract: Methotrexate (MTX) is a folic acid antagonist used at high-dose intravenously on 24 hours (24h) in the treatment of the acute lymphoblastic leukemia (ALL). To prevent potential toxicity, MTX is usually administered following the application of preventive measures. We report a case of an accidental shortening time for high dose MTX infusion and a literature review of accidental intoxications by the MTX. This case illustrates the importance of the respect of MTX high dose infusion time and the major role played by the therapeutic drug monitoring.
authors.affiliation: Service de pharmacologie clinique, Centre national de pharmacovigilance de Tunis, Tunisia. charfirim@yahoo.fr
authors.forename: Rim
authors.initials: R
authors.lastname: Charfi
authors.forename: Issam
authors.initials: I
authors.lastname: Salouage
authors.forename: Sameh
authors.initials: S
authors.lastname: Trabelsi
authors.forename: Mohamed
authors.initials: M
authors.lastname: Zarrouk
authors.forename: Emna
authors.initials: E
authors.lastname: Gaïes
authors.forename: Nadia
authors.initials: N
authors.lastname: Jebabli
authors.forename: Balkis
authors.initials: B
authors.lastname: Meddeb
authors.forename: Mohamed
authors.initials: M
authors.lastname: Lakhal
authors.forename: Anis
authors.initials: A
authors.lastname: Klouz
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005493:Folic Acid Antagonists / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D008508:Medication Errors; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects*; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
chemical_list: D000964:Antimetabolites, Antineoplastic; D005493:Folic Acid Antagonists; D008727:Methotrexate
keywords: high dose methotrexate; intoxication; therapeutic drug monitoring