title: [Role of contemporary pathological diagnostics in the personalized treatment of cancer].
abstract: Due to the developments of pathology in the past decades (immunohistochemistry and molecular pathology) classification of cancers changed fundamentally, laying a ground for personalized management of cancer patients. Our picture of cancer is more complex today, identifying the genetic basis of the morphological variants. On the other hand, this picture has a much higher resolution enabling us to subclassify similar histological cancer types based on molecular markers. This redefined classification of cancers helps us to better predict the possible biological behavior of the disease and/or the therapeutic sensitivity, opening the way toward a more personalized treatment of this disease. The redefined molecular classification of cancer may affect the universal application of treatment protocols. To achieve this goal molecular diagnostics must be an integral and reimbursed part of the routine pathological diagnostics. On the other hand, it is time to extend the multidisciplinary team with molecular pathologist to improve the decision making process of the management of cancer patients.
authors.affiliation: Klinikai Központ, MTA-SE Daganatprogresszió Kutatócsoport, Budapest, Hungary. jtimar@gmail.com
authors.forename: József
authors.initials: J
authors.lastname: Tímár
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000175:diagnosis; D000077192:Adenocarcinoma of Lung; D000465:Algorithms; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000737:chemistry / Q000145:classification* / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D015179:Colorectal Neoplasms / Q000737:chemistry / Q000145:classification* / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000145:classification* / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008545:Melanoma / Q000145:classification / Q000175:diagnosis; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics; D009369:Neoplasms / Q000145:classification / Q000175:diagnosis; D057089:Pathology, Molecular / Q000379:methods / Q000639:trends; D057285:Precision Medicine / Q000379:methods / Q000639:trends; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000145:classification / Q000175:diagnosis; D013964:Thyroid Neoplasms / Q000145:classification / Q000175:diagnosis
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins