title: An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers.
abstract: A multifunctional nanoplatform with four-in-one photoresponsive functionalities has been achieved through the co-encapsulation of two chromo-fluorogenic components within biocompatible polymeric nanoparticles. This engineered nanoconstruct efficiently delivers different photosensitizers in melanoma cells, which can be detected through their dual-color fluorescence, and induces amplified cell mortality due to the simultaneous photogeneration of singlet oxygen and nitric oxide.
authors.affiliation: Laboratory of Photochemistry, Department of Drug Sciences, University of Catania, I-95125 Catania, Italy.
authors.forename: Aurore
authors.initials: A
authors.lastname: Fraix
authors.forename: Noufal
authors.initials: N
authors.lastname: Kandoth
authors.forename: Ilse
authors.initials: I
authors.lastname: Manet
authors.forename: Venera
authors.initials: V
authors.lastname: Cardile
authors.forename: Adriana C E
authors.initials: AC
authors.lastname: Graziano
authors.forename: Ruxandra
authors.initials: R
authors.lastname: Gref
authors.forename: Salvatore
authors.initials: S
authors.lastname: Sortino
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D016923:Cell Death / Q000187:drug effects; D003116:Color; D005453:Fluorescence; D006801:Humans; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy*; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D010789:Phototherapy; D011108:Polymers / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D017319:Photosensitizing Agents; D011108:Polymers