title: Changes in spontaneous activity assessed by accelerometry correlate with extent of cerebral ischemia-reperfusion injury in the nonhuman primate.
abstract: The use of accelerometry to monitor activity in human stroke patients has revealed strong correlations between objective activity measurements and subjective neurological findings. The goal of our study was to assess the applicability of accelerometry-based measurements in experimental animals undergoing surgically-induced cerebral ischemia. Using a nonhuman primate cortical stroke model, we demonstrate for the first time that monitoring locomotor activity prior to and following cerebrovascular ischemic injury using an accelerometer is feasible in adult male rhesus macaques and that the measured activity outcomes significantly correlate with severity of brain injury. The use of accelerometry as an unobtrusive, objective preclinical efficacy determinant could complement standard practices involving subjective neurological scoring and magnetic resonance imaging in nonhuman primates. Similar activity monitoring devices to those employed in this study are currently in use in human clinical studies, underscoring the feasibility of this approach for assessing the clinical potential of novel treatments for cerebral ischemia.
authors.affiliation: Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA ; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA.
authors.forename: Henryk F
authors.initials: HF
authors.lastname: Urbanski
authors.forename: Steven G
authors.initials: SG
authors.lastname: Kohama
authors.forename: G Alexander
authors.initials: GA
authors.lastname: West
authors.forename: Christine
authors.initials: C
authors.lastname: Glynn
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Williams-Karnesky
authors.forename: Eric
authors.initials: E
authors.lastname: Earl
authors.forename: Martha N
authors.initials: MN
authors.lastname: Neuringer
authors.forename: Lauren
authors.initials: L
authors.lastname: Renner
authors.forename: Alison
authors.initials: A
authors.lastname: Weiss
authors.forename: Mary
authors.initials: M
authors.lastname: Stenzel-Poore
authors.forename: Frances Rena
authors.initials: FR
authors.lastname: Bahjat
keywords: accelerometer; actigraphy; ischemia; nonhuman primate; rhesus macaque; stroke