title: Type I retinopathy of prematurity in infants with birth weight less than 1251 g: incidence and risk factors for its development in a nursery in Kuwait.
abstract: OBJECTIVE
  To report the rate of acute retinopathy of prematurity (ROP) and Type I ROP among infants with birth weight (BW) <1251 g and identify the risk factors for the development of Type I ROP.
  
  
  METHODS
  A retrospective review of ROP records of infants with BW <1251 g was performed to identify infants with acute ROP and Type I ROP. Infants with Type I ROP were compared with those without Type I ROP to assess the risk factors for the development of Type I ROP. P < 0.05 was statistically significant. Multivariate analysis was performed and odds ratio (OR) and 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  Among the 207 infants with BW <1251 g, acute ROP occurred in 154 infants (74.4%) and Type I ROP in 95 eyes of 50 infants (24.4%). The numbers of infants with BW <750 g and BW <1000 g were 19.3% and 58.4%, respectively, and the incidences of Type I ROP were 50% and 36.4%, respectively, among them. Forty-four (46.3%) eyes were treated at stage 2+ ROP in zone I or II. All the eyes treated for Type I ROP showed complete regression. Gestational age at birth (OR 0.657, 95% CI: 0.521-0.827; P < 0.0001) and number of ventilated days (OR 1.017, 95% CI: 1.005-1.029; P = 0.006) were identified as independent risk factors for the development of Type I ROP.
  
  
  CONCLUSIONS
  The rate of Type I ROP in this study is higher than that in previous studies due to the higher number of infants with BW <1000 g in our cohort and the treatment of more eyes with stage 2+ ROP. However, all the treated eyes had a favorable outcome. Gestational age at birth and number of ventilated days were independent risk factors for the development of Type I ROP.
authors.affiliation: Department of Ophthalmology, Al-Adan Hospital, Hadiya, Kuwait.
authors.forename: Vivek B
authors.initials: VB
authors.lastname: Wani
authors.forename: Anil K
authors.initials: AK
authors.lastname: Uboweja
authors.forename: Muzaffar
authors.initials: M
authors.lastname: Gani
authors.forename: Jamal
authors.initials: J
authors.lastname: Al-Kandari
authors.forename: Mahmood
authors.initials: M
authors.lastname: Kazem
authors.forename: Niran
authors.initials: N
authors.lastname: Al-Naqeeb
authors.forename: Cherian
authors.initials: C
authors.lastname: Thomas
authors.forename: Murad
authors.initials: M
authors.lastname: Al-Serafi
authors.forename: Mumtaz M
authors.initials: MM
authors.lastname: Shukkur
mesh_terms: D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007730:Kuwait / Q000453:epidemiology; D008297:Male; D009725:Nurseries, Hospital / Q000706:statistics & numerical data; D012178:Retinopathy of Prematurity / Q000145:classification / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Incidence; Retinopathy of Prematurity; Risk Factors; Type I Retinopathy of Prematurity