title: Angiotensin II modulates salty and sweet taste sensitivities.
abstract: Understanding the mechanisms underlying gustatory detection of dietary sodium is important for the prevention and treatment of hypertension. Here, we show that Angiotensin II (AngII), a major mediator of body fluid and sodium homeostasis, modulates salty and sweet taste sensitivities, and that this modulation critically influences ingestive behaviors in mice. Gustatory nerve recording demonstrated that AngII suppressed amiloride-sensitive taste responses to NaCl. Surprisingly, AngII also enhanced nerve responses to sweeteners, but had no effect on responses to KCl, sour, bitter, or umami tastants. These effects of AngII on nerve responses were blocked by the angiotensin II type 1 receptor (AT1) antagonist CV11974. In behavioral tests, CV11974 treatment reduced the stimulated high licking rate to NaCl and sweeteners in water-restricted mice with elevated plasma AngII levels. In taste cells AT1 proteins were coexpressed with αENaC (epithelial sodium channel α-subunit, an amiloride-sensitive salt taste receptor) or T1r3 (a sweet taste receptor component). These results suggest that the taste organ is a peripheral target of AngII. The specific reduction of amiloride-sensitive salt taste sensitivity by AngII may contribute to increased sodium intake. Furthermore, AngII may contribute to increased energy intake by enhancing sweet responses. The linkage between salty and sweet preferences via AngII signaling may optimize sodium and calorie intakes.
authors.affiliation: Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors.forename: Noriatsu
authors.initials: N
authors.lastname: Shigemura
authors.forename: Shusuke
authors.initials: S
authors.lastname: Iwata
authors.forename: Keiko
authors.initials: K
authors.lastname: Yasumatsu
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Ohkuri
authors.forename: Nao
authors.initials: N
authors.lastname: Horio
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sanematsu
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Yoshida
authors.forename: Robert F
authors.initials: RF
authors.lastname: Margolskee
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Ninomiya
mesh_terms: D000450:Aldosterone / Q000378:metabolism; D000584:Amiloride / Q000494:pharmacology; D000804:Angiotensin II / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D001713:Biphenyl Compounds; D002814:Chorda Tympani Nerve / Q000502:physiology; D062686:Epithelial Sodium Channel Blockers / Q000494:pharmacology; D053503:Epithelial Sodium Channels / Q000096:biosynthesis; D005260:Female; D005518:Food Preferences / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010949:Plasma / Q000378:metabolism; D044139:Receptor, Angiotensin, Type 2 / Q000096:biosynthesis; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000096:biosynthesis; D050053:TRPM Cation Channels / Q000096:biosynthesis; D013649:Taste / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D013650:Taste Buds / Q000378:metabolism; D055697:Taste Perception / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D013777:Tetrazoles / Q000494:pharmacology
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001713:Biphenyl Compounds; C543264:Cnr1 protein, rat; D062686:Epithelial Sodium Channel Blockers; D053503:Epithelial Sodium Channels; D044139:Receptor, Angiotensin, Type 2; D043884:Receptor, Cannabinoid, CB1; D043562:Receptors, G-Protein-Coupled; D050053:TRPM Cation Channels; D013777:Tetrazoles; C498617:Trpm5 protein, mouse; C431926:taste receptors, type 1; D000804:Angiotensin II; D000450:Aldosterone; D000584:Amiloride; C081643:candesartan