title: OptiMAS: a decision support tool for marker-assisted assembly of diverse alleles.
abstract: Current advances in plant genotyping lead to major progress in the knowledge of genetic architecture of traits of interest. It is increasingly important to develop decision support tools to help breeders and geneticists to conduct marker-assisted selection methods to assemble favorable alleles that are discovered. Algorithms have been implemented, within an interactive graphical interface, to 1) trace parental alleles throughout generations, 2) propose strategies to select the best plants based on estimated molecular scores, and 3) efficiently intermate them depending on the expected value of their progenies. With the possibility to consider a multi-allelic context, OptiMAS opens new prospects to assemble favorable alleles issued from diverse parents and further accelerate genetic gain.
authors.affiliation: INRA, UMR 0320/UMR 8120 Génétique Végétale, F-91190 Gif-sur-Yvette, France.
authors.forename: Fabio
authors.initials: F
authors.lastname: Valente
authors.forename: Franck
authors.initials: F
authors.lastname: Gauthier
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bardol
authors.forename: Guylaine
authors.initials: G
authors.lastname: Blanc
authors.forename: Johann
authors.initials: J
authors.lastname: Joets
authors.forename: Alain
authors.initials: A
authors.lastname: Charcosset
authors.forename: Laurence
authors.initials: L
authors.lastname: Moreau
mesh_terms: D000465:Algorithms; D000483:Alleles; D001947:Breeding / Q000379:methods; D002874:Chromosome Mapping / Q000379:methods; D003661:Decision Support Techniques; D017343:Genes, Plant / Q000502:physiology; D005819:Genetic Markers / Q000502:physiology*; D014644:Genetic Variation; D010641:Phenotype; D010802:Phylogeny; D010944:Plants / Q000235:genetics; D040641:Quantitative Trait Loci / Q000235:genetics / Q000502:physiology; D012641:Selection, Genetic / Q000235:genetics
chemical_list: D005819:Genetic Markers
keywords: QTL; gene pyramiding; marker-assisted selection; multiparental designs; plant breeding