title: Unwinding the Wnt action of casein kinase 1.
abstract: The casein kinase 1 (CK1) family, a major intracellular serine/threonine kinase, is implicated in multiple pathways; however, understanding its regulation has proven challenging. A recent study published in Science identifying allosteric activation of CK1 by the DEAD-box RNA helicase DDX3 expands our understanding of the control of this abundant kinase family.
authors.affiliation: Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School Singapore, Singapore.
authors.forename: Daniel G R
authors.initials: DG
authors.lastname: Yim
authors.forename: David M
authors.initials: DM
authors.lastname: Virshup
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans; D047389:Casein Kinase I / Q000378:metabolism*; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D006801:Humans; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D014981:Xenopus
chemical_list: D051153:Wnt Proteins; D047389:Casein Kinase I; C119332:DDX3X protein, human; D053487:DEAD-box RNA Helicases