title: Role of skeletal muscle proteoglycans during myogenesis.
abstract: Skeletal muscle formation during development and the adult mammal consists of a highly organised and regulated the sequence of cellular processes intending to form or repair muscle tissue. This sequence includes, cell proliferation, migration, and differentiation. Proteoglycans (PGs), macromolecules formed by a core protein and glycosaminoglycan chains (GAGs) present a great diversity of functions explained by their capacity to interact with different ligands and receptors forming part of their signalling complex and/or protecting them from proteolytic cleavage. Particularly attractive is the function of the different types of PGs present at the neuromuscular junction (NMJ). This review is focussed on the advances reached to understand the role of PGs during myogenesis and skeletal muscular dystrophies.
authors.affiliation: Centro de Envejecimiento y Regeneración, CARE, Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, P. Universidad Católica de Chile, Santiago, Chile. ebrandan@bio.puc.cl
authors.forename: Enrique
authors.initials: E
authors.lastname: Brandan
authors.forename: Jaime
authors.initials: J
authors.lastname: Gutierrez
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D018507:Gene Expression Regulation, Developmental; D006025:Glycosaminoglycans / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D024510:Muscle Development / Q000235:genetics*; D018482:Muscle, Skeletal / Q000254:growth & development / Q000378:metabolism* / Q000473:pathology; D009136:Muscular Dystrophies / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009469:Neuromuscular Junction / Q000254:growth & development / Q000378:metabolism* / Q000473:pathology; D011509:Proteoglycans / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D059748:Proteolysis; D015398:Signal Transduction
chemical_list: D006025:Glycosaminoglycans; D036341:Intercellular Signaling Peptides and Proteins; D011509:Proteoglycans
keywords: Fibrosis; Growth factors; Muscular diseases; Proteoglycans; Skeletal muscle formation