title: Diagnostic accuracy of risk of malignancy index in predicting complete tumor removal at primary debulking surgery for ovarian cancer patients.
abstract: Ovarian cancer patients in whom complete tumor removal is impossible with primary debulking surgery (PDS) may benefit from neoadjuvant chemotherapy and interval debulking surgery. However, the task of performing a pre-operative evaluation of the feasibility of PDS is difficult. We aimed to investigate whether the risk of malignancy index (RMI) was a useful marker for this evaluation. RMI and surgical outcome were investigated in 164 patients, 49 of whom had no residual tumor after PDS. The receiver operating characteristic curve showed an area under the curve of 0.72 (confidence interval: 0.64-0.80). The possibility of complete tumor removal decreased with increasing RMI and there was a tendency towards higher RMI in patients with residual tumor after PDS, but no single cut-off value of RMI produced useful clinical predictive values. In conclusion, RMI alone is not an optimal method to determine whether complete tumor removal is possible with PDS.
authors.affiliation: Department of Gynecology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. fagoe-olsen@regionh.dk
authors.forename: Carsten L
authors.initials: CL
authors.lastname: Fagö-Olsen
authors.forename: Fanny
authors.initials: F
authors.lastname: Håkansson
authors.forename: Sofie L
authors.initials: SL
authors.lastname: Antonsen
authors.forename: Estrid
authors.initials: E
authors.lastname: Høgdall
authors.forename: Lene
authors.initials: L
authors.lastname: Lundvall
authors.forename: Lotte
authors.initials: L
authors.lastname: Nedergaard
authors.forename: Svend A
authors.initials: SA
authors.lastname: Engelholm
authors.forename: Claus
authors.initials: C
authors.lastname: Høgdall
mesh_terms: D000367:Age Factors; D000368:Aged; D018394:CA-125 Antigen / Q000097:blood; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000097:blood; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000473:pathology; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery*; D012372:ROC Curve; D018570:Risk Assessment
chemical_list: D018394:CA-125 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins