title: Laparoscopic versus open radical cystectomy for muscle-invasive bladder cancer: a single institute comparative analysis.
abstract: BACKGROUND
  Open radical cystectomy (ORC) is the gold standard of treatment for muscle-invasive bladder cancer. Laparoscopic radical cystectomy (LRC) has emerged to provide an alternative.
  
  
  METHODS
  Between 2006 and 2012, 155 patients who underwent LRC or ORC were compared (mean follow-up 53 months).
  
  
  RESULTS
  The ORC group had shorter operative times (p < 0.0001), more blood loss (p < 0.00001), more transfusion requirement (p < 0.00001), longer postoperative length of hospital stay (p < 0.00001) and more morphine requirement (p = 0.02). No difference was found regarding lymph node yield (p = 0.07), positive margins (p = 0.11), cystectomy pathology results (p > 0.05) and positive lymph nodes (p = 0.02). The ORC group had less intraoperative complications (p = 0.03). No difference was found between the two groups regarding 5-year overall survival (p = 0.93), cancer-specific survival (p = 0.7) and recurrence-free survival (p = 0.62).
  
  
  CONCLUSIONS
  LRC can be considered as an alternative to ORC with good operative and postoperative results in addition to comparable 5-year survival results.
authors.affiliation: College of Medicine, Islamic University of Gaza, Palestine. aboumarzouk@gmail.com
authors.forename: Omar M
authors.initials: OM
authors.lastname: Aboumarzouk
authors.forename: Tomasz
authors.initials: T
authors.lastname: Drewa
authors.forename: Pawel
authors.initials: P
authors.lastname: Olejniczak
authors.forename: Piotr L
authors.initials: PL
authors.lastname: Chlosta
mesh_terms: D000368:Aged; D001803:Blood Transfusion; D015653:Cystectomy / Q000379:methods*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D009361:Neoplasm Invasiveness; D061646:Operative Time; D011184:Postoperative Period; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000601:surgery*