title: [Anaphylaxis. Diagnostic and therapeutic management].
abstract: Anaphylaxis is a severe, potentially life-threatening, systemic allergic reaction, which generally happens unexpectedly in healthy individuals. Among children, the most common elicitors are food, insect stings, and drugs. Currently, the incidence of anaphylaxis is increasing. Risk factors are asthma, infections as well as previous, sudden respiratory and cardiovascular symptoms after exposure to a specific antigen. If cutaneous, respiratory, gastrointestinal, cardiovascular and neurologic symptoms involving ≥2 organ systems occur, adrenaline/epinephrine, preferably intramuscularly, should be administered. Although allergen skin testing and serological estimation of specific IgE antibodies do not predict who will develop anaphylaxis, they help to identify sensitized individuals at risk. Patients with a history of anaphylaxis need training on how to use the emergency medication and how to recognize and prevent the anaphylactic symptoms.
authors.affiliation: Klinik für Kinder- und Jugendmedizin, Universitätsklinik Köln, Kerpener Str. 62, 50924, Köln. ernst.rietschel@uk-koeln.de
authors.forename: E
authors.initials: E
authors.lastname: Rietschel
authors.forename: I
authors.initials: I
authors.lastname: Hutegger
authors.forename: L
authors.initials: L
authors.lastname: Lange
authors.forename: R
authors.initials: R
authors.lastname: Urbanek
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D000707:Anaphylaxis / Q000175:diagnosis* / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control / Q000628:therapy; D004632:Emergency Medical Services / Q000379:methods*; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D008297:Male; D012307:Risk Factors; D055502:Secondary Prevention; D012646:Self Administration; D055815:Young Adult
chemical_list: D007073:Immunoglobulin E; D004837:Epinephrine