title: Correlation of thermodilution-derived extravascular lung water and ventilation/perfusion-compartments in a porcine model.
abstract: OBJECTIVE
  This study examines the correlation between the transpulmonary thermodilution derived extravascular lung water content (EVLW) and the ventilation/perfusion-distribution ([Formula: see text]) measured by multiple inert gas elimination (MIGET) in a porcine model.
  
  
  METHODS
  [Formula: see text] measured by micropore membrane inlet mass spectrometry-MIGET (MMIMS-MIGET) and EVLW were simultaneously measured in twelve pigs in the heathy state, with impaired gas exchange from repetitive lung lavage and after 3 h of ventilation. The relationship between [Formula: see text] compartments and EVLW was analysed by linear correlation and regression.
  
  
  RESULTS
  Considerable increases in EVLW and [Formula: see text] mismatching were induced through the lavage procedure. Significant correlations between the EVLW and the [Formula: see text] fractions representing pulmonary shunt and low [Formula: see text] were found. Perfusion to the normal [Formula: see text] regions was inversely correlated to the EVLW.
  
  
  CONCLUSIONS
  Increased EVLW is associated with increased low [Formula: see text] and shunt, but not equal to pulmonary shunt alone. Beneath true shunt EVLW can also be associated with low [Formula: see text] regions.
authors.affiliation: Department of Anaesthesiology, Medical Center of the Johannes Gutenberg-University, Langenbeckstraße 1, 55131, Mainz, Germany. hartmane@uni-mainz.de
authors.forename: Erik K
authors.initials: EK
authors.lastname: Hartmann
authors.forename: Bastian
authors.initials: B
authors.lastname: Duenges
authors.forename: James E
authors.initials: JE
authors.lastname: Baumgardner
authors.forename: Klaus
authors.initials: K
authors.lastname: Markstaller
authors.forename: Matthias
authors.initials: M
authors.lastname: David
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis / Q000295:instrumentation*; D004195:Disease Models, Animal; D015633:Extravascular Lung Water; D016014:Linear Models; D013058:Mass Spectrometry / Q000295:instrumentation; D008567:Membranes, Artificial; D008851:Micropore Filters; D011652:Pulmonary Circulation; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*; D013552:Swine; D013815:Thermodilution; D014692:Ventilation-Perfusion Ratio
chemical_list: D008567:Membranes, Artificial