title: Oligonol supplementation attenuates body temperature and the circulating levels of prostaglandin E2 and cyclooxygenase-2 after heat stress in humans.
abstract: Oligonol, a phenolic production from lychee, has been reported to exhibit anti-oxidative and anti-inflammatory effects. This study investigated the effect of Oligonol supplementation on circulating levels of prostaglandin E2 (PGE2) and cyclooxygenase (COX)-2, as well as body temperature, after heat stress in 17 healthy human male volunteers (age, 21.6±2.1 years). All experiments were performed in an automated climate chamber (26.0°C±0.5°C, relative humidity 60%±3.0%, air velocity less than 1 m/sec) between 2 and 5 p.m. Subjects ingested an Oligonol (100 mg)-containing beverage or placebo beverage before half-body immersion into hot water (42°C±0.5°C for 30 min). Tympanic and skin temperatures were measured and mean body temperatures were calculated. Serum concentrations of PGE2 and COX-2 were analyzed before, immediately after, and 60 min after immersion. Oligonol intake significantly prevented elevation of tympanic (temperature difference: 0.17°C at Post, P<.05; 0.17°C at Re-60, P<.05) and mean body temperatures (temperature difference: 0.18°C at Post, P<.05; 0.15°C at Re-60, P<.05), and lowered concentrations of serum PGE2 (increased by 13.3% vs. 29.6% at Post, P<.05) and COX-2 (increased by 15.6% vs. 21.8% at Post, P<.05), compared to placebo beverage. Our result suggests that Oligonol has the potential to suppress increases in body temperature under heat stress, and this is associated with decreases in serum levels of PGE2 and COX-2.
authors.affiliation: Department of Healthcare, Global Graduate School, Soonchunhyang University, Asan, Korea.
authors.forename: Young Oh
authors.initials: YO
authors.lastname: Shin
authors.forename: Jeong Beom
authors.initials: JB
authors.lastname: Lee
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Song
authors.forename: Young Ki
authors.initials: YK
authors.lastname: Min
authors.forename: Hun Mo
authors.initials: HM
authors.lastname: Yang
mesh_terms: D000328:Adult; D001831:Body Temperature / Q000187:drug effects*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051546:Cyclooxygenase 2 / Q000097:blood*; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology; D019587:Dietary Supplements; D015232:Dinoprostone / Q000097:blood*; D006358:Hot Temperature; D006801:Humans; D007101:Immersion; D032125:Litchi / Q000737:chemistry*; D008297:Male; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D012016:Reference Values; D012881:Skin Temperature; D013312:Stress, Physiological / Q000187:drug effects; D014867:Water; D055815:Young Adult
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D010636:Phenols; D010936:Plant Extracts; C514283:oligonol; D014867:Water; D002392:Catechin; D051546:Cyclooxygenase 2; D015232:Dinoprostone