title: Validity of a new optic disc grading software for use in clinical and epidemiological research.
abstract: BACKGROUND
  To determine the reliability and agreement of a new optic disc grading software program for use in clinical, epidemiological research.
  
  
  METHODS
  Reliability and agreement study.
  
  
  METHODS
  328 monoscopic and 85 stereoscopic optic disc images.
  
  
  METHODS
  Optic disc parameters were measured using a new optic disc grading software (Singapore Optic Disc Assessment) that is based on polynomial curve-fitting algorithm. Two graders independently graded 328 monoscopic images to determine intergrader reliability. One grader regraded the images after 1 month to determine intragrader reliability. In addition, 85 stereo optic disc images were separately selected, and vertical cup-to-disc ratios were measured using both the new software and standardized Wisconsin manual stereo-grading method by the same grader 1 month apart. Intraclass correlation coefficient (ICC) and Bland-Altman plot analyses were performed.
  
  
  METHODS
  Optic disc parameters.
  
  
  RESULTS
  The intragrader and intergrader reliability for optic disc measurements using Singapore Optic Disc Assessment was high (ICC ranging from 0.82 to 0.94). The mean differences (95% limits of agreement) for intergrader vertical cup-to-disc ratio measurements were 0.00 (-0.12 to 0.13) and 0.03 (-0.15 to 0.09), respectively. The vertical cup-to-disc ratio agreement between the software and Wisconsin grading method was extremely close (ICC = 0.94). The mean difference (95% limits of agreement) of vertical cup-to-disc ratio measurement between the two methods was 0.03 (-0.09 to 0.16).
  
  
  CONCLUSIONS
  Intragrader and intergrader reliability using Singapore Optic Disc Assessment was excellent. This software was highly comparable with standardized stereo-grading method. Singapore Optic Disc Assessment is useful for grading digital optic disc images in clinical, population-based studies.
authors.affiliation: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, Singapore.
authors.forename: Yih-Chung
authors.initials: YC
authors.lastname: Tham
authors.forename: Carol Y
authors.initials: CY
authors.lastname: Cheung
authors.forename: Tien Y
authors.initials: TY
authors.lastname: Wong
authors.forename: Mani
authors.initials: M
authors.lastname: Baskaran
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
authors.forename: Beng-Hai
authors.initials: BH
authors.lastname: Lee
authors.forename: Fengshou
authors.initials: F
authors.lastname: Yin
authors.forename: Damon W K
authors.initials: DW
authors.lastname: Wong
authors.forename: Jie Jin
authors.initials: JJ
authors.lastname: Wang
authors.forename: Paul
authors.initials: P
authors.lastname: Mitchell
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
authors.forename: Ching-Yu
authors.initials: CY
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D015340:Epidemiologic Research Design; D005260:Female; D005901:Glaucoma / Q000145:classification* / Q000175:diagnosis / Q000208:ethnology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000145:classification*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000145:classification* / Q000175:diagnosis / Q000208:ethnology; D010781:Photography; D015203:Reproducibility of Results; D012846:Singapore / Q000453:epidemiology; D012984:Software
keywords: epidemiology; optic disc; optic nerve evaluation