title: A new turn-on fluorescent probe for selective detection of glutathione and cysteine in living cells.
abstract: A fluorescent probe (N-(4-methyl-2-oxo-2H-chromen-7-yl)-2,4-dinitrobenzenesulfonamide), which exhibits high selectivity to glutathione and cysteine among amino acids including sulphur-containing methionine and metal ions, was synthesized. The experiments demonstrate that the fluorescent probe is a reliable and specific probe for glutathione and cysteine in living cells.
authors.affiliation: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.
authors.forename: Mingjie
authors.initials: M
authors.lastname: Wei
authors.forename: Peng
authors.initials: P
authors.lastname: Yin
authors.forename: Youming
authors.initials: Y
authors.lastname: Shen
authors.forename: Lingli
authors.initials: L
authors.lastname: Zhang
authors.forename: Jianhui
authors.initials: J
authors.lastname: Deng
authors.forename: Shanyan
authors.initials: S
authors.lastname: Xue
authors.forename: Haitao
authors.initials: H
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Guo
authors.forename: Youyu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shouzhuo
authors.initials: S
authors.lastname: Yao
mesh_terms: D003374:Coumarins / Q000737:chemistry*; D003545:Cysteine / Q000032:analysis*; D005456:Fluorescent Dyes / Q000737:chemistry*; D005978:Glutathione / Q000032:analysis*; D006367:HeLa Cells; D006801:Humans; D008301:Maleimides / Q000737:chemistry; D008856:Microscopy, Fluorescence; D013449:Sulfonamides / Q000737:chemistry*; D000096926:Benzenesulfonamides
chemical_list: D003374:Coumarins; D003545:Cysteine; D005456:Fluorescent Dyes; D005978:Glutathione; D008301:Maleimides; D013449:Sulfonamides; C584297:N-(4-methyl-2-oxo-2H-chromen-7-yl)-2,4-dinitrobenzenesulfonamide; D000096926:Benzenesulfonamides; C527323:N-methylmaleimide