title: From a multipotent stilbene to soluble epoxide hydrolase inhibitors with antiproliferative properties.
abstract: Inspired by nature: Natural product isopropylstilbene was identified as an inhibitor of soluble epoxide hydrolase exhibiting antiproliferative properties. Following the natural product inspired design approach, a library of (E)-styryl-1H-benzo[d]imidazoles was synthesized and evaluated with recombinant enzyme and on several cancer cell lines.
authors.affiliation: Institut für Pharmazeutische Chemie, Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany.
authors.forename: Estella
authors.initials: E
authors.lastname: Buscató
authors.forename: Dominik
authors.initials: D
authors.lastname: Büttner
authors.forename: Astrid
authors.initials: A
authors.lastname: Brüggerhoff
authors.forename: Franca-Maria
authors.initials: FM
authors.lastname: Klingler
authors.forename: Julia
authors.initials: J
authors.lastname: Weber
authors.forename: Bastian
authors.initials: B
authors.lastname: Scholz
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Zivković
authors.forename: Rolf
authors.initials: R
authors.lastname: Marschalek
authors.forename: Holger
authors.initials: H
authors.lastname: Stark
authors.forename: Dieter
authors.initials: D
authors.lastname: Steinhilber
authors.forename: Helge B
authors.initials: HB
authors.lastname: Bode
authors.forename: Ewgenij
authors.initials: E
authors.lastname: Proschak
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D008958:Models, Molecular; D015394:Molecular Structure; D012995:Solubility; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D020298:U937 Cells
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D013267:Stilbenes; D004851:Epoxide Hydrolases