title: [Lung adenocarcinoma with intramedullary spinal cord metastasis: a case report and review of the literature].
abstract: Intramedullary spinal cord metastases are extremely rare and affect 0.1 to 0.4% of all cancer patients. We report the case of intramedullary metastases in a 42-year-old patient, 12 months after the initial diagnosis of a lung adenocarcinoma. The patient was on third-line chemotherapy for a progressive disease with node and bone metastases. He complained of weakness and difficulty walking. The MRI permitted confirmation of the diagnosis. Corticotherapy was started and the patient underwent radiotherapy. A targeted therapy was indicated. The patient died three months after the initiation of this treatment. The aim of this paper is to report a new case of intramedullary spinal cord metastases from a pulmonary adenocarcinoma, focus on its rarity and diagnostic and therapeutic difficulties through a review of the literature.
authors.affiliation: Service de carcinologie médicale, institut Salah-Azaiz, faculté de médecine de Tunis, Tunis, Tunisie. belaid_im@hotmail.fr
authors.forename: I
authors.initials: I
authors.lastname: Belaid
authors.forename: H
authors.initials: H
authors.lastname: Jlassi
authors.forename: G
authors.initials: G
authors.lastname: Debbiche
authors.forename: H
authors.initials: H
authors.lastname: Rais
authors.forename: F
authors.initials: F
authors.lastname: Ben Ayed
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018450:Disease Progression; D000069347:Erlotinib Hydrochloride; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D011799:Quinazolines / Q000008:administration & dosage; D011859:Radiography; D013120:Spinal Cord Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D000069347:Erlotinib Hydrochloride