title: Enantioselective ketone hydroacylation using Noyori's transfer hydrogenation catalyst.
abstract: An enantioselective ketone hydroacylation enables the direct preparation of lactones from keto alcohols. The alcohol is oxidized in situ to an aldehyde, obviating the need to prepare sensitive keto aldehyde substrates. Noyori's asymmetric transfer hydrogenation catalyst was applied to address challenges of reactivity, chemoselectivity, and enantioselectivity.
authors.affiliation: Department of Chemistry, University of California, Irvine, California 92697-2025, USA.
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Murphy
authors.forename: Vy M
authors.initials: VM
authors.lastname: Dong
mesh_terms: D000215:Acylation; D002384:Catalysis; D006865:Hydrogenation; D007659:Ketones / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D007659:Ketones