title: An inflammatory vicious cycle: Fibroblasts and immune cell recruitment in cancer.
abstract: Cancer-associated fibroblasts (CAFs) have been established as a key component of the crosstalk between tumor cells and their microenvironment. The ability of CAFs to orchestrate tumor-promoting inflammation is central to their role in facilitating tumor growth, invasion, and metastasis. Here we review pathways by which CAFs and their soluble mediators provide multiple complex signals that modulate the recruitment, functional activation status, and retention of immune cells in the tumor microenvironment.
authors.affiliation: Lis Maternity Hospital, Tel Aviv Sorasky Medical Center, affiliated to Sackler School of Medicine, Tel Aviv, Israel; Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel-Aviv 69978, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Raz
authors.affiliation: Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel-Aviv 69978, Israel. Electronic address: netaerez@post.tau.ac.il.
authors.forename: Neta
authors.initials: N
authors.lastname: Erez
mesh_terms: D000818:Animals; D005347:Fibroblasts / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000473:pathology; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D059016:Tumor Microenvironment / Q000276:immunology*
keywords: Cancer; Cancer-associated fibroblasts; Inflammation; Microenvironment