title: Harnessing DCs by substance P.
abstract: In this issue of Blood, Janelsins et al report that substance P (SP)–treated dendritic cells (DCs) efficiently home to lymph nodes, where they induce inflammatory DCs to produce interleukin-12 (IL-12), thereby promoting type 1 polarized immunity.
authors.affiliation: University of Toledo.
authors.forename: Akira
authors.initials: A
authors.lastname: Takashima
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D007111:Immunity, Cellular / Q000276:immunology*; D018664:Interleukin-12 / Q000276:immunology*; D018040:Receptors, Neurokinin-1 / Q000276:immunology*
chemical_list: D018040:Receptors, Neurokinin-1; D018664:Interleukin-12