title: New cytotoxic steroids from the leaves of Clerodendrum trichotomum.
abstract: A phytochemical investigation of the leaves of Clerodendrum trichotomum led to the isolation of five new (2-6) and two known (1 and 7) steroids, whose structures and relative configurations were elucidated by comprehensive spectroscopic analysis and by comparison of their NMR data with those of related compounds. Steroids 2 and 5 exhibited moderate cytotoxicity in vitro against HeLa cell line.
authors.affiliation: Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.
authors.forename: Rui-Lan
authors.initials: RL
authors.lastname: Xu
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Lan
authors.initials: L
authors.lastname: Ding
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Shi
mesh_terms: D032409:Clerodendrum / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry*
chemical_list: D013256:Steroids