title: Effect of osmotic-release oral system methylphenidate on learning skills in adolescents with attention-deficit/hyperactivity disorder: an open-label study.
abstract: We evaluated the effect of osmotic-release oral system (OROS) methylphenidate on learning skills in adolescents with attention-deficit/hyperactivity disorder (ADHD). In an open-label study, 121 adolescents with ADHD were administered flexible doses of OROS methylphenidate for 12 weeks. The efficacy of methylphenidate on ADHD symptoms was evaluated by ADHD Rating Scale (ARS) and Clinical Global Impression Scale (CGI). Learning Skills Test (LST) was used to measure the learning skills of the participants at the baseline and the endpoint. Continuous performance test, visuospatial and verbal working memory, verbal fluency, and inhibition were evaluated before and after the 12 weeks of treatment. The mean total and subscores of LST were significantly increased after the 12-week treatment with OROS methylphenidate. Executive functions were also improved during the trial, with the exception of inhibition measured by the Stroop Test. To the best of our knowledge, this is the first study to examine the influence of OROS methylphenidate on learning skill. As a result, OROS methylphenidate was effective in enhancing learning skills in adolescents with ADHD.
authors.affiliation: Department of Psychiatry, College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
authors.forename: Kyoung-Sae
authors.initials: KS
authors.lastname: Na
authors.forename: Soyoung Irene
authors.initials: SI
authors.lastname: Lee
authors.forename: Sungdo David
authors.initials: SD
authors.lastname: Hong
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Se-Hoon
authors.initials: SH
authors.lastname: Shim
authors.forename: Jeewook
authors.initials: J
authors.lastname: Choi
authors.forename: Jaewon
authors.initials: J
authors.lastname: Yang
authors.forename: Moon-Soo
authors.initials: MS
authors.lastname: Lee
authors.forename: Yoo-Sook
authors.initials: YS
authors.lastname: Joung
authors.forename: Eui-Jung
authors.initials: EJ
authors.lastname: Kim
authors.forename: Joon-Ho
authors.initials: JH
authors.lastname: Park
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000855:Anorexia / Q000139:chemically induced / Q000453:epidemiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D039721:Diagnostic and Statistical Manual of Mental Disorders; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D056344:Executive Function / Q000187:drug effects; D005260:Female; D006801:Humans; D015994:Incidence; D007266:Inhibition, Psychological; D007858:Learning / Q000187:drug effects; D007859:Learning Disabilities / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D008774:Methylphenidate / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D009997:Osmotic Pressure; D013064:Speech Disorders / Q000209:etiology / Q000517:prevention & control
chemical_list: D003692:Delayed-Action Preparations; D018765:Dopamine Uptake Inhibitors; D008774:Methylphenidate