title: First trimester prediction of early onset preeclampsia using demographic, clinical, and sonographic data: a cohort study.
abstract: OBJECTIVE
  The aim of this research was to evaluate the performance of a predictive model for early onset preeclampsia (PE) during early gestation.
  
  
  METHODS
  Prospective multicenter cohort study was performed in women attending 11-14 weeks ultrasound. Medical history and biometrical variables were recorded and uterine artery Doppler was performed. All patients were followed until postpartum period. Constructed predictive models were compared using the area under the associated receiver operating characteristic curve. Sensitivity, specificity, and likelihood ratios were estimated for each outcome.
  
  
  RESULTS
  A total of 627 patients were enrolled. Sixty-five (10.4%) developed gestational hypertension, of which 29 developed PE (4.6% of the total sample) and nine occurred before 34 weeks (1.5% of total sample). Prediction model generated for early onset PE (ePE) with 5% false positive achieve sensitivity of 62.5% and specificity of 95.5%. The positive and negative likelihood ratios for ePE were 13.9 and 0.39, respectively. Development of ePE was significantly associated with history of preterm labor (p = 0.002) and diabetes mellitus (p = 0.02).
  
  
  CONCLUSIONS
  This study confirms the advantage of combining multiple variables for prediction of ePE.
authors.affiliation: Universidad de los Andes, Fetal Medicine Unit, Departments of Obstetrics & Gynecology and Reproduction Biology Laboratory, Santiago, Chile. javier.caradeux@gmail.com
authors.forename: Javier
authors.initials: J
authors.lastname: Caradeux
authors.forename: Ramón
authors.initials: R
authors.lastname: Serra
authors.forename: Jyh-Kae
authors.initials: JK
authors.lastname: Nien
authors.forename: Alejandra
authors.initials: A
authors.lastname: Pérez-Sepulveda
authors.forename: Manuel
authors.initials: M
authors.lastname: Schepeler
authors.forename: Francisco
authors.initials: F
authors.lastname: Guerra
authors.forename: Jorge
authors.initials: J
authors.lastname: Gutiérrez
authors.forename: Jaime
authors.initials: J
authors.lastname: Martínez
authors.forename: Cristián
authors.initials: C
authors.lastname: Cabrera
authors.forename: Horacio
authors.initials: H
authors.lastname: Figueroa-Diesel
authors.forename: Peter
authors.initials: P
authors.lastname: Soothill
authors.forename: Sebastián E
authors.initials: SE
authors.lastname: Illanes
mesh_terms: D000328:Adult; D015331:Cohort Studies; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000209:etiology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011379:Prognosis; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012959:Socioeconomic Factors; D013997:Time Factors; D016216:Ultrasonography, Prenatal; D055815:Young Adult