title: A new isobenzofuranone from the mangrove endophytic fungus Penicillium sp. (ZH58).
abstract: A new isobenzofuranone, 4-(methoxymethyl)-7-methoxy-6-methyl-1(3H)-isobenzofuranone (1), together with seven known compounds, dilation (2), lumichrome (3), curvulari (4), 5,5'-oxy-dimethylene-bis(2-furaldehyde) (5), chromone (6), harman(1-methyl-β-carboline) (7), N9-methyl-1methyl-β-carboline (8), was isolated from the mangrove endophytic fungus, Penicillium sp. ZH58 obtained from the South China Sea coast. Their structures were determined by analysis of spectroscopic data. Compound 1 exhibited cytotoxicity against KB and KBV200 cells with IC50 values of 6 and 10 μg/mL, respectively.
authors.affiliation: a Laboratory of Natural Product Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou , 510650 , P.R. China.
authors.forename: Jianxiang
authors.initials: J
authors.lastname: Yang
authors.forename: Riming
authors.initials: R
authors.lastname: Huang
authors.forename: Sheng Xiang
authors.initials: SX
authors.lastname: Qiu
authors.forename: Zhigang
authors.initials: Z
authors.lastname: She
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Lin
mesh_terms: D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification*; D002460:Cell Line; D002681:China; D045424:Complex Mixtures / Q000032:analysis*; D005285:Fermentation; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D043982:Rhizophoraceae / Q000382:microbiology*; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: C000589095:4-(methoxymethyl)-7-methoxy-6-methyl-1(3H)-isobenzofuranone; D001572:Benzofurans; D045424:Complex Mixtures; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue