title: An altered relationship of influenza vaccine-specific IgG responses with T cell immunity occurs with aging in humans.
abstract: Alterations in T cell immunity occur with aging. Influenza causes significant morbidity and mortality in the elderly. We investigated the relationship of serum IgG responses with hemagglutinin inhibition (HI) antibody titers and the frequency of distinct T cell subsets in young and elderly people who received the inactivated influenza vaccine. Influenza vaccine-specific IgG responses correlated with the increase of HI antibody titers and the frequency of CD4(+) T cells producing IFN-γ and IL-17 in young, but not elderly, people. Also, only in young people, such IgG responses correlated with the frequency of memory T cells, especially central memory cells, CD45RA(-) effector memory CD8(+) T cells and IL-7 receptor alpha high effector memory CD8(+) T cells with potent survival and proliferative capacity. These findings suggest that aging alters the association of influenza-vaccine specific IgG responses with HI antibody titers, cytokine-producing capacity and proportions of memory T cells in humans.
authors.affiliation: Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Ki Soo
authors.initials: KS
authors.lastname: Kang
authors.forename: Naeun
authors.initials: N
authors.lastname: Lee
authors.forename: Min Sun
authors.initials: MS
authors.lastname: Shin
authors.forename: Sang Doo
authors.initials: SD
authors.lastname: Kim
authors.forename: Yinyi
authors.initials: Y
authors.lastname: Yu
authors.forename: Subhasis
authors.initials: S
authors.lastname: Mohanty
authors.forename: Robert B
authors.initials: RB
authors.lastname: Belshe
authors.forename: Ruth R
authors.initials: RR
authors.lastname: Montgomery
authors.forename: Albert C
authors.initials: AC
authors.lastname: Shaw
authors.forename: Insoo
authors.initials: I
authors.lastname: Kang
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood / Q000276:immunology*; D000914:Antibodies, Viral / Q000097:blood*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D006388:Hemagglutinins / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology; D020381:Interleukin-17 / Q000276:immunology; D008297:Male; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D006388:Hemagglutinins; D007074:Immunoglobulin G; D007252:Influenza Vaccines; D020381:Interleukin-17; D007371:Interferon-gamma