title: Evolution of Health-Related Quality of Life in Breast Cancer Patients during the First Year of Follow-Up.
abstract: OBJECTIVE
  The objective of this study was to describe the evolution of health-related quality of life (HRQOL) in a cohort of breast cancer patients over 1 year after surgery and to analyse the predictive ability of HRQOL measurement instruments.
  
  
  METHODS
  Observational, multicenter and prospective study of a cohort of breast cancer patients, assessing HRQOL at 1, 6, and 12 months after surgery using three questionnaires: EuroQol-5D-3L, EORTC QLQ-C30, and EORTC QLQ-BR23.
  
  
  RESULTS
  A total of 364 women participated in the study. Visual Analogue Scale (VAS) scores from the EuroQol improved (1 month vs. 1 year: 70 vs. 80; p<0.0001); however, the EuroQol score showed no significant change (0.81 vs. 0.83; p=0.1323). In contrast, Global Health Status on the EORTC QLQ-C30 improved (66.67 vs. 100.00; p<0.0001), as did all of this instrument's scales and most of its independent items. The EORTC QLQ-BR23 dimensions showed improvement, except for sexual functioning (100.00 vs. 86.67; p=0.0030) and future perspective (33.33 vs. 66.67; p<0.0001). Patients with good HRQOL outcomes at 1 month showed improved levels of HRQOL at 1 year; HRQOL measured at 1 month was predictive of HRQOL at 1 year.
  
  
  CONCLUSIONS
  HRQOL improved during the follow-up period. Likewise, HRQOL measurement instruments can predict early HRQOL.
authors.affiliation: Department of Surgery, Hospital Clínico Universitario de Valencia, Valencia, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Moro-Valdezate
authors.forename: Salvador
authors.initials: S
authors.lastname: Peiró
authors.forename: Elvira
authors.initials: E
authors.lastname: Buch-Villa
authors.forename: Antonio
authors.initials: A
authors.lastname: Caballero-Gárate
authors.forename: M Dolores
authors.initials: MD
authors.lastname: Morales-Monsalve
authors.forename: Angel
authors.initials: A
authors.lastname: Martínez-Agulló
authors.forename: Félix
authors.initials: F
authors.lastname: Checa-Ayet
authors.forename: Joaquín
authors.initials: J
authors.lastname: Ortega-Serrano
keywords: Breast neoplasms; Quality of life; Questionnaires