title: [Regeneration strategies of intervertebral disc].
abstract: OBJECTIVE
  To review the research progress of the seed cells, scaffolds, growth factors, and the prospects for clinical application of the intervertebral disc regeneration.
  
  
  METHODS
  The recent literature concerning the regeneration strategies and tissue engineering for treatment of degenerative intervertebral disc disease was extensively reviewed and summarized.
  
  
  RESULTS
  Seed cells based on mesenchymal stem cells (MSCs) and multiple-designed biomimetic scaffolds are the hot topic in the field of intervertebral disc regeneration. It needs to be further investigated how to effectively combine the interactions of seed cells, scaffolds, and growth factors and to play their regulation function.
  
  
  CONCLUSIONS
  The biological regeneration of intervertebral disc would have a very broad prospects for clinical application in future.
authors.affiliation: Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
authors.forename: Weili
authors.initials: W
authors.lastname: Fu
authors.forename: Zhou
authors.initials: Z
authors.lastname: Xiang
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism* / Q000494:pharmacology; D007403:Intervertebral Disc / Q000473:pathology / Q000502:physiology*; D055959:Intervertebral Disc Degeneration / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000502:physiology; D011108:Polymers / Q000737:chemistry; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D020100:Hydrogels; D036341:Intercellular Signaling Peptides and Proteins; D011108:Polymers