title: Low-grade osteosarcoma of the lung diagnosed at the time of recurrence.
abstract: An abnormal shadow was detected in a 75-year-old man on a chest roentgenogram, and the patient was referred to our institution. A transbronchial biopsy was carried out and the specimen resulted in a diagnosis of organizing pneumonia. During the follow-up period, the left lung lesion became enlarged. Partial resection of the left lung was performed. Postoperatively, pathological examination of the tumor showed an organizing pneumonia. Approximately 3 years later, a new calcified heterogeneous mass shadow was detected in the left lung and left pleura, which had gradually enlarged. Computed tomography (CT)-guided fine-needle biopsy of the nodule of the left pleura was performed. Microscopically, the specimen led to the diagnosis of low-grade osteosarcoma. Re-evaluation of the primary and secondary lesions were confirmed as the same histopathological findings. A further systemic examination was performed. Finally, the lesion was confirmed as low-grade osteosarcoma of the lung. The patient refused further treatment and died due to respiratory failure.
authors.affiliation: Department of Thoracic Surgery, National Hospital Organization Kyoto Medical Center.
authors.forename: Makoto
authors.initials: M
authors.lastname: Motoishi
authors.forename: Keigo
authors.initials: K
authors.lastname: Okamoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kataoka
authors.forename: Satoru
authors.initials: S
authors.lastname: Sawai
authors.forename: Mayumi
authors.initials: M
authors.lastname: Oshio
authors.forename: Jun
authors.initials: J
authors.lastname: Hanaoka
mesh_terms: D000368:Aged; D018549:Cryptogenic Organizing Pneumonia / Q000175:diagnosis; D003951:Diagnostic Errors; D017809:Fatal Outcome; D006801:Humans; D061705:Image-Guided Biopsy; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery*; D008297:Male; D009364:Neoplasm Recurrence, Local; D012516:Osteosarcoma / Q000473:pathology* / Q000601:surgery*; D011013:Pneumonectomy; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D016312:Treatment Refusal