title: Molecular recognition of sulfotyrosine and phosphotyrosine by the Src homology 2 domain.
abstract: We study molecular recognition of two closely resembling posttranslational modification products, phosphotyrosine (pTyr) and sulfotyrosine (sTyr). The differences in charge, size, and binding geometry of pTyr and sTyr are the main recognition elements. Protein engineering can be applied to alter the specificity and strength of the recognition.
authors.affiliation: Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304, USA.
authors.forename: Tong
authors.initials: T
authors.lastname: Ju
authors.forename: Wei
authors.initials: W
authors.lastname: Niu
authors.forename: Ronald
authors.initials: R
authors.lastname: Cerny
authors.forename: Joshua
authors.initials: J
authors.lastname: Bollman
authors.forename: Anthony
authors.initials: A
authors.lastname: Roy
authors.forename: Jiantao
authors.initials: J
authors.lastname: Guo
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D019000:Phosphotyrosine / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D050794:STAT1 Transcription Factor / Q000737:chemistry / Q000378:metabolism; D016415:Sequence Alignment; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D018909:src Homology Domains / Q000502:physiology*
chemical_list: D050794:STAT1 Transcription Factor; D019000:Phosphotyrosine; C005662:tyrosine O-sulfate; D014443:Tyrosine