title: Identification of an atypical variant of logopenic progressive aphasia.
abstract: The purpose of this study was to examine the association between aphasia severity and neurocognitive function, disease duration and temporoparietal atrophy in 21 individuals with the logopenic variant of primary progressive aphasia (lvPPA). We found significant correlations between aphasia severity and degree of neurocognitive impairment as well as temporoparietal atrophy; but not disease duration. Cluster analysis identified three variants of lvPPA: (1) subjects with mild aphasia and short disease duration (mild typical lvPPA); (2) subjects with mild aphasia and long disease duration (mild atypical lvPPA); and, (3) subjects with severe aphasia and relatively long disease duration (severe typical lvPPA). All three variants showed temporoparietal atrophy, with the mild atypical group showing the least atrophy despite the longest disease duration. The mild atypical group also showed mild neuropsychological impairment. The subjects with mild aphasia and neuropsychological impairment despite long disease duration may represent a slowly progressive variant of lvPPA.
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States. Electronic address: machulda.mary@mayo.edu.
authors.forename: Mary M
authors.initials: MM
authors.lastname: Machulda
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Whitwell
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Duffy
authors.forename: Edythe A
authors.initials: EA
authors.lastname: Strand
authors.forename: Pamela M
authors.initials: PM
authors.lastname: Dean
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Senjem
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
mesh_terms: D000368:Aged; D018888:Aphasia, Primary Progressive / Q000150:complications* / Q000473:pathology*; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D016000:Cluster Analysis; D003072:Cognition Disorders / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
keywords: Logopenic aphasia; Neurocognitive impairment; Primary progressive aphasia; Temporoparietal atrophy; Voxel-based morphometry