title: Effects of vinpocetine on random skin flap survival in rats.
abstract: The effect of vinpocetine on flap survival, vascular endothelial growth factor (VEGF) expression, and superoxide dismutase (SOD) and malondialdehyde (MDA) contents were evaluated in this study. The McFarlane flap model was established in 20 rats and evaluated within two groups. Postoperative celiac injection was given for 7 days in the two groups: vinpocetine was applied in Group 1, and the same volume of saline was applied in Group 2. Flap necrosis was measured on day 7 by cellophane in all groups. VEGF expression was determined using immunohistochemical methods on tissue samples taken after 7 days of injections. SOD and MDA contents were examined according to the Kit (reagent instructions). Vinpocetine significantly reduced necrosis area in Group 1 (p < 0.05). VEGF expression and SOD contents were significantly increased in Group 1 compared with Group 2 (p < 0.01), whereas MDA level was reduced (p < 0.05). This experimental study demonstrates that vinpocetine improves survival of random skin flaps, promotes neovascularization, and increases VEGF expression. Meanwhile, vinpocetine has a protective effect against ischemia-reperfusion injury by improving SOD vitality and decreasing MDA value.
authors.affiliation: Department of Plastic and Hand Surgery, The 2nd Affiliated Hospital of Wenzhou Medical College, The Second Clinical Medical College of Wenzhou Medical College, Wenzhou, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xiao-Xiao
authors.forename: Wu
authors.initials: W
authors.lastname: Sen-Min
authors.forename: Lin
authors.initials: L
authors.lastname: Ding-Sheng
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006085:Graft Survival / Q000187:drug effects*; D007150:Immunohistochemistry; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D015427:Reperfusion Injury / Q000517:prevention & control*; D012680:Sensitivity and Specificity; D016038:Skin Transplantation / Q000009:adverse effects / Q000379:methods*; D013482:Superoxide Dismutase / Q000378:metabolism; D013524:Surgical Flaps / Q000098:blood supply* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D014748:Vinca Alkaloids / Q000008:administration & dosage*
chemical_list: D042461:Vascular Endothelial Growth Factor A; D014748:Vinca Alkaloids; D008315:Malondialdehyde; C013983:vinpocetine; D013482:Superoxide Dismutase