title: Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis.
abstract: Sertaconazole is a useful antifungal agent against mycoses of the skin and mucosa, such as cutaneous, genital and oral candidiasis and tinea pedis. Its antifungal activity is due to inhibition of the ergosterol biosynthesis and disruption of the cell wall. At higher concentrations, sertaconazole is able to bind to nonsterol lipids of the fungal cell wall, increasing the permeability and the subsequent death of fungal cells. Fungistatic and fungicidal activities on Candida are dose-dependent. The antifungal spectrum of sertaconazole includes deramophytes, Candida, Cryptococcus, Malassezia and also Aspergillus, Scedosporium and Scopulariopsis. Sertaconazole also shows an antimicrobial activity against streptococci, staphylococci and protozoa (Trichomonas). In clinical trials including patients with vulvovaginal candidiasis, a single dose of sertaconazole produced a higher cure rate compared with other topical azoles such as econazole and clotrimazole, in shorter periods. Sertaconazole has shown an anti-inflammatory effect that is very useful for the relief of unpleasant symptoms.
authors.affiliation: Department of Microbiology-Mycology, ACIAM, Barcelona, Spain. acarrillo@aciam.es
authors.forename: Alfonso Javier
authors.initials: AJ
authors.lastname: Carrillo-Muñoz
authors.forename: Cristina
authors.initials: C
authors.lastname: Tur-Tur
authors.forename: Gustavo
authors.initials: G
authors.lastname: Giusiano
authors.forename: Cristina
authors.initials: C
authors.lastname: Marcos-Arias
authors.forename: Elena
authors.initials: E
authors.lastname: Eraso
authors.forename: Nerea
authors.initials: N
authors.lastname: Jauregizar
authors.forename: Guillermo
authors.initials: G
authors.lastname: Quindós
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects* / Q000502:physiology; D002177:Candidiasis / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007093:Imidazoles / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D013207:Staphylococcal Skin Infections / Q000188:drug therapy; D013290:Streptococcal Infections / Q000178:diet therapy; D013876:Thiophenes / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007093:Imidazoles; D013876:Thiophenes; C061131:sertaconazole