title: Image-guided percutaneous core needle biopsy of musculoskeletal tumors in children.
abstract: The use of image-guided percutaneous core needle biopsy (PCNB) to obtain tissue diagnosis of musculoskeletal lesions has become the standard of care in adult patients with a success rate of over 80%. Previous reports indicate a similar success rate in diagnosing pediatric solid tumors. In this large study, we analyzed >10 years of data in which PCNB was used for tissue diagnosis of musculoskeletal lesions in children; we evaluated the histopathologic accuracy, anesthetic requirements, and complications of these procedures. In 122 children, tissue diagnosis was successfully obtained in 82% of cases, and there were 0 complications associated with the procedure. There was a significantly higher PCNB diagnostic success rate in malignant lesions (93%). These data suggest that the use of PCNB is a safe and effective means of diagnosing musculoskeletal lesions in children.
authors.affiliation: *Department of Pediatrics, Division of Pediatric Hematology/Oncology ‡Department of Medicine, Division of Hematology/Oncology §Department of Surgery, Division of Surgical Oncology Departments of †Radiology ∥Pathology ¶Orthopedic Surgery, University of California, Los Angeles, Los Angeles CA.
authors.forename: Bryan
authors.initials: B
authors.lastname: Mitton
authors.forename: Leanne L
authors.initials: LL
authors.lastname: Seeger
authors.forename: Mark A
authors.initials: MA
authors.lastname: Eckardt
authors.forename: Kambiz
authors.initials: K
authors.lastname: Motamedi
authors.forename: Fritz C
authors.initials: FC
authors.lastname: Eilber
authors.forename: Scott D
authors.initials: SD
authors.lastname: Nelson
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Eckardt
authors.forename: Noah
authors.initials: N
authors.lastname: Federman
mesh_terms: D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D061705:Image-Guided Biopsy; D007223:Infant; D008297:Male; D009140:Musculoskeletal Diseases / Q000175:diagnosis* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult