title: Long-term clinical effects of programmer-guided atrioventricular and interventricular delay optimization: Intracardiac electrography versus echocardiography for cardiac resynchronization therapy in patients with heart failure.
abstract: OBJECTIVE
  To compare the haemodynamic results and long-term clinical outcomes of intracardiac electrography (QuickOpt®; St Jude Medical, St Paul, MN, USA) and echocardiography for optimization of atrioventricular (AV) and interventricular (VV) delays in cardiac resynchronization therapy (CRT).
  
  
  METHODS
  Patients with CRT devices were prospectively enrolled; AV/VV delays were optimized by either QuickOpt® or echocardiography. Patients in the QuickOpt® group underwent both echocardiography and QuickOpt® optimization, and QuickOpt® AV/VV delays were used to program the CRT. All patients were followed-up for 12 months.
  
  
  RESULTS
  In total, 44 patients were enrolled. There was good correlation between AV/VV delays determined by QuickOpt® (n = 20) and echocardiography (n = 24). QuickOpt® was significantly faster than echocardiography-guided optimization. Cardiac function, 6-min walking distance and left ventricular ejection fraction were significantly and similarly improved in both groups at 6 and 12 months compared with baseline. In the QuickOpt® group, left ventricular end diastolic diameters were significantly smaller at 6 and 12 months compared with baseline.
  
  
  CONCLUSIONS
  QuickOpt® is a quick, convenient and easy to perform method for optimization of AV and VV delays, with a similar long-term clinical outcome to echocardiography-guided optimization.
authors.affiliation: Department of Cardiology, Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wang
authors.forename: Haibo
authors.initials: H
authors.lastname: Yu
authors.forename: Tian
authors.initials: T
authors.lastname: Yun
authors.forename: Hongyun
authors.initials: H
authors.lastname: Zang
authors.forename: Guitang
authors.initials: G
authors.lastname: Yang
authors.forename: Shouli
authors.initials: S
authors.lastname: Wang
authors.forename: Zulu
authors.initials: Z
authors.lastname: Wang
authors.forename: Quanmin
authors.initials: Q
authors.lastname: Jing
authors.forename: Yaling
authors.initials: Y
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058406:Cardiac Resynchronization Therapy; D003710:Demography; D004452:Echocardiography; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D006333:Heart Failure / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors