title: Supplementation with a juice powder concentrate and exercise decrease oxidation and inflammation, and improve the microcirculation in obese women: randomised controlled trial data.
abstract: Obesity and sedentary lifestyle are associated with increased oxidative stress, inflammation and vessel dysfunction. Previous research has shown that an encapsulated fruit/berry/vegetable juice powder (FBV) supplement or controlled exercise training improve the markers of redox biology, low-grade inflammation and circulation. The aim of the present study was to assess the effects of 8 weeks of supplementation with FBV or placebo, and a single bout of controlled walking on the markers of oxidation, inflammation and skin capillary microcirculation in forty-two obese pre-menopausal women (41 (SD 5) years, non-smokers and BMI 34·5 (SD 3·8) kg/m(2)) using a randomised, double-blind, placebo-controlled design. All assessments were made before and after 8 weeks of capsule supplementation, and pre- and post-30 min of controlled treadmill walking at 70 % of VO2max. Venous blood was collected for the determination of carbonyl proteins (CP), oxidised LDL (ox-LDL), total oxidation status (TOS) of lipids, malondialdehyde, TNF-α and IL-6. Capillary blood flow, O2 saturation of Hb (SO2Hb) and the relative concentration of Hb (rHb) were assessed at a 2 mm skin depth. Following 8 weeks of supplementation, compared with placebo, the FBV group had a significant (P< 0·05) reduction in CP, ox-LDL, TOS and TNF-α, and a significant increase in blood flow, SO2Hb and rHb. Independent of supplementation, moderate exercise significantly increased blood flow and rHb, with a trend towards increased SO2Hb. Compared with placebo, 8 weeks of supplementation with FBV decreased the markers of systemic oxidation and inflammation. Both FBV supplementation and a single walking bout improved the markers of the microcirculation in these obese women.
authors.affiliation: Institute of Physiological Chemistry, Centre for Physiological Medicine, Medical University of Graz, Harrachgasse 21/II, 8010 Graz, Austria.
authors.forename: Manfred
authors.initials: M
authors.lastname: Lamprecht
authors.forename: Georg
authors.initials: G
authors.lastname: Obermayer
authors.forename: Kurt
authors.initials: K
authors.lastname: Steinbauer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Cvirn
authors.forename: Lidija
authors.initials: L
authors.lastname: Hofmann
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ledinski
authors.forename: Joachim F
authors.initials: JF
authors.lastname: Greilberger
authors.forename: Seth
authors.initials: S
authors.lastname: Hallstroem
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002196:Capillaries; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005638:Fruit; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000188:drug therapy*; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood; D008833:Microcirculation / Q000187:drug effects*; D009765:Obesity / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D010101:Oxygen Consumption; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*; D050050:Protein Carbonylation / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014675:Vegetables; D016138:Walking
chemical_list: D008077:Lipoproteins, LDL; D028321:Plant Preparations; D014409:Tumor Necrosis Factor-alpha; C099252:oxidized low density lipoprotein