title: Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging.
abstract: Biomimetic synthesis has become a promising green pathway to prepare nanomaterials. In this study, bovine serum albumin (BSA)-conjugated gold nanoclusters/nanoparticles were successfully synthesized in water at room temperature by a protein-directed, solution-phase, green synthetic method. The synthesized BSA-Au nanocomplexes have fluorescence emission (588 nm) of gold nanoclusters and surface plasmon resonance of gold nanoparticles. The BSA-Au nanocomplexes display non-cytotoxicity and excellent biocompatibility on MGC803 gastric cancer cells. After conjugation of folic acid molecules, the obtained BSA-Au nanocomplexes showed highly selective targeting for MGC803 cells and dual-modality dark-field and fluorescence imaging.
authors.affiliation: Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People's Republic of China. dxcui@sjtu.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhou
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Li
authors.forename: Chunlei
authors.initials: C
authors.lastname: Zhang
authors.forename: Xiansong
authors.initials: X
authors.lastname: Wang
authors.forename: Kan
authors.initials: K
authors.lastname: Wang
authors.forename: Guo
authors.initials: G
authors.lastname: Gao
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Daxiang
authors.initials: D
authors.lastname: Cui