title: Effect of glucocorticoids on nasal polyposis, with detection of inflammatory response by measurement of nitric oxide levels in nasal polyp tissue.
abstract: OBJECTIVE
  To investigate endoscopic staging, and nitric oxide levels in the polyp tissue, in patients with nasal polyposis undergoing glucocorticoid therapy.
  
  
  METHODS
  Nasal polyposis was evaluated using endoscopic staging and measurement of polyp tissue nitric oxide levels (chemiluminescence method). Forty-five nasal polyposis patients received either nasal therapy (n = 15), oral therapy (n = 15) or combined therapy (n = 15). Pre-treatment and post-treatment staging and nitric oxide levels were evaluated.
  
  
  RESULTS
  Endoscopic grading indicated significant post-treatment staging improvements in the oral (p = 0.016) and combined (p = 0.016) groups. Post-treatment staging differed significantly between the three groups (p = 0.041), with greater improvements in the oral and combined groups. All groups showed significantly lower post-treatment nitric oxide levels, compared with baseline, but post-treatment levels did not differ significantly between groups. A significant association was found between treatment response and nitric oxide level alteration.
  
  
  CONCLUSIONS
  This study demonstrates the favourable effects of glucocorticoids on nasal polyposis, and alteration in nitric oxide tissue levels post-treatment. Nitric oxide level in nasal polyp tissue could be an indicator of treatment response, and may aid surgical decision-making by detecting cases that probably will not respond to medical treatment.
authors.affiliation: Department of Otorhinolaryngology, Haydarpaşa Numune Education and Research Hospital, Istanbul, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Bülbül
authors.forename: O Gümüştekin
authors.initials: OG
authors.lastname: Bülbül
authors.forename: O
authors.initials: O
authors.lastname: Güçlü
authors.forename: A Serpil
authors.initials: AS
authors.lastname: Bilsel
authors.forename: S Önal
authors.initials: SÖ
authors.lastname: Gürsan
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D009297:Nasal Mucosa / Q000737:chemistry / Q000378:metabolism; D009298:Nasal Polyps / Q000737:chemistry / Q000188:drug therapy* / Q000378:metabolism; D009569:Nitric Oxide / Q000032:analysis* / Q000378:metabolism; D012720:Severity of Illness Index
chemical_list: D005938:Glucocorticoids; D009569:Nitric Oxide