title: Transient increased exudation after photodynamic therapy of intraocular tumors.
abstract: To report transient increased exudation after photodynamic therapy (PDT) of three different intraocular tumors (retinal hemangioblastoma, retinal astrocytoma, amelanotic choroidal melanoma). PDT with verteporfin (6 mg/m(2) body surface area) was delivered at a dose of 50 J/cm(2) and intensity of 600 mW/cm(2) over 83 s. All patients experienced decreased vision within a few days following PDT. Optical coherence tomography showed development of subfoveal fluid in all cases and noncystoid intraretinal edema in the eye with juxtapapillary retinal hemangioblastoma. There was complete absorption of retinal/subretinal fluid with improvement of visual acuity to 20/20 in all cases between 3 weeks to 4 months after PDT.
authors.affiliation: Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Arman
authors.initials: A
authors.lastname: Mashayekhi
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Shields
mesh_terms: D000293:Adolescent; D001254:Astrocytoma / Q000188:drug therapy; D002830:Choroid Neoplasms / Q000188:drug therapy*; D005260:Female; D005451:Fluorescein Angiography; D018325:Hemangioblastoma / Q000188:drug therapy; D006801:Humans; D018328:Melanoma, Amelanotic / Q000188:drug therapy; D008875:Middle Aged; D010211:Papilledema / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011166:Porphyrins / Q000627:therapeutic use; D011183:Postoperative Complications; D019572:Retinal Neoplasms / Q000188:drug therapy*; D058471:Subretinal Fluid; D041623:Tomography, Optical Coherence; D000077362:Verteporfin; D014786:Vision Disorders / Q000209:etiology / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin
keywords: Astrocytoma; Choroidal Melanoma; Complication; Exudation; Eye; Photodynamic Therapy; Retinal Hemangioblastoma; Serous Retinal Detachment; Tumor