title: The complexity of arterial classical monocyte recruitment.
abstract: Accumulation of classical monocytes is imperative for the progression of atherosclerosis. Hence, therapeutic interference with mechanisms of lesional monocyte recruitment, the primary mechanism controlling macrophage accumulation, may allow for targeting atheroprogression and its clinical complications. Here, we review the important role of classical monocytes in atheroprogression as well as their routes of arterial recruitment. We specifically highlight the role of cell adhesion molecules as well as of platelet-derived chemokines and neutrophil-borne alarmins.
authors.affiliation: Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany. maik.drechsler@med.uni-muenchen.de
authors.forename: Maik
authors.initials: M
authors.lastname: Drechsler
authors.forename: Oliver
authors.initials: O
authors.lastname: Soehnlein
mesh_terms: D000818:Animals; D001158:Arteries / Q000276:immunology*; D050197:Atherosclerosis / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D018925:Chemokines / Q000276:immunology; D018450:Disease Progression; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D058990:Molecular Targeted Therapy; D009504:Neutrophils / Q000276:immunology*
chemical_list: D015815:Cell Adhesion Molecules; D018925:Chemokines