title: Glucose-6-phosphate-dehydrogenase deficiency and its correlation with other risk factors in jaundiced newborns in Southern Brazil.
abstract: OBJECTIVE
  To evaluate the correlation between glucose-6-phosphate-dehydrogenase (G6PD) deficiency and neonatal jaundice.
  
  
  METHODS
  Prospective, observational case-control study was conducted on 490 newborns admitted to Hospital de Clínicas de Porto Alegre for phototherapy, who all experienced 35 or more weeks of gestation, from March to December 2007. Enzymatic screening of G6PD activity was performed, followed by PCR.
  
  
  RESULTS
  There was prevalence of 4.6% and a boy-girl ratio of 3:1 in jaundiced newborns. No jaundiced neonate with ABO incompatibility presented G6PD deficiency, and no Mediterranean mutation was found. A higher proportion of deficiency was observed in Afro-descendants. There was no association with UGT1A1 variants.
  
  
  CONCLUSIONS
  G6PD deficiency is not related to severe hyperbilirubinemia and considering the high miscegenation in this area of Brazil, other gene interactions should be investigated.
authors.affiliation: Genetics Service, Hospital de Clínicas de Porto Alegre, PGP in Pediatrics, UFRGS, Porto Alegre, RS, Brazil.
authors.forename: Clarissa Gutiérrez
authors.initials: CG
authors.lastname: Carvalho
authors.forename: Simone Martins
authors.initials: SM
authors.lastname: Castro
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Santin
authors.forename: Carina
authors.initials: C
authors.lastname: Zaleski
authors.forename: Felipe Gutiérrez
authors.initials: FG
authors.lastname: Carvalho
authors.forename: Roberto
authors.initials: R
authors.lastname: Giugliani
mesh_terms: D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics / Q000378:metabolism*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications / Q000201:enzymology* / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000201:enzymology* / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D008297:Male; D009154:Mutation; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D005954:Glucosephosphate Dehydrogenase
keywords: Glucosephosphate dehydrogenase; Hemoglobin; Hyperbilirubinemia; Jaundice; Neonatal