title: Human hippocampal increases in low-frequency power during associative prediction violations.
abstract: Environmental cues often trigger memories of past events (associative retrieval), and these memories are a form of prediction about imminent experience. Learning is driven by the detection of prediction violations, when the past and present diverge. Using intracranial electroencephalography (iEEG), we show that associative prediction violations elicit increased low-frequency power (in the slow-theta range) in human hippocampus, that this low-frequency power increase is modulated by whether conditions allow predictions to be generated, that the increase rapidly onsets after the moment of violation, and that changes in low-frequency power are not present in adjacent perirhinal cortex. These data suggest that associative mismatch is computed within hippocampus when cues trigger predictions that are violated by imminent experience.
authors.affiliation: Stanford Human Intracranial Cognitive Electrophysiology Program (SHICEP), United States; Department of Psychology, Stanford University, United States; Princeton Neuroscience Institute, Princeton University, Green Hall, Princeton, NJ 08542, United States. Electronic address: janice@princeton.edu.
authors.forename: Janice
authors.initials: J
authors.lastname: Chen
authors.forename: Mohammad
authors.initials: M
authors.lastname: Dastjerdi
authors.forename: Brett L
authors.initials: BL
authors.lastname: Foster
authors.forename: Karen F
authors.initials: KF
authors.lastname: LaRocque
authors.forename: Andreas M
authors.initials: AM
authors.lastname: Rauschecker
authors.forename: Josef
authors.initials: J
authors.lastname: Parvizi
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Wagner
mesh_terms: D000328:Adult; D001245:Association Learning / Q000502:physiology*; D004569:Electroencephalography; D005074:Evoked Potentials, Visual; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000502:physiology; D013826:Theta Rhythm; D055815:Young Adult
keywords: Associative memory; Hippocampus; Intracranial EEG; Mismatch; Novelty; Prediction violation