title: [Associations between TGF-β1 G/A and TNF-α 308 G/A gene polymorphisms with airway resistance in chronic obstructive pulmonary disease].
abstract: BACKGROUND
  Chronic obstructive pulmonary disease (COPD) is an important morbidity and mortality cause all over the world. Although specific gene region has not been defined in the pathogenesis of COPD, cytokine gene polymorphisms like tumor necrosis factor-alfa (TNF-α) and transforming growth factor-beta1 (TGF-β1) may contribute to the development of COPD. The aim of the present study was to evaluate the associations between airway resistance with TGF-β1 G/A and TNF-α 308 G/A gene polymorphisms in COPD patients.
  
  
  METHODS
  264 subjects were included to the study (Group 1; 75 COPD patients, Group 2; 139 subjects with at least 10 packet year smoking history without airflow obstruction, Group 3; 50 healthy subjects). Pulmonary function tests and body plethysmography to measure airway resistance were performed to the subjects. TGF-β1 800 G/A and TNF-α 308 G/A gene polymorphisms were evaluated. Chi-square, Anova and correlation analysis were used for statistical analysis.
  
  
  RESULTS
  There were significant difference among COPD stages in terms of TNF-α 308 G/A polymorphism (p< 0.05). Thirteen (23.6%) stage 1 COPD patients had TNF-α 308 G/A polymorphism and the other did not have. We did not find statistically significant difference among COPD stages in terms of TGF-β1 800 G/A polymorphism (p> 0.05). TNF-α and TGF-β1 genotypes and TNF-a 308 G/A and TGF-β1 800 G/A polymorphisms were not different among study groups. Moreover, no significant differences betweeen subjects with and without increased airway resistance in terms of TNF-α 308 G/A and TGF-β1 800 G/A polymorphisms were present.
  
  
  CONCLUSIONS
  These results can suggest the lack of association between TNF-α 308 G/A and TGF-β1 800 G/A gene polymorphisms with COPD development and airway resistance in Turkish population.
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Kevser
authors.initials: K
authors.lastname: Melek
authors.forename: Gaye
authors.initials: G
authors.lastname: Ulubay
authors.forename: Sevinç
authors.initials: S
authors.lastname: Sarınç Ulaşlı
authors.forename: Hasibe
authors.initials: H
authors.lastname: Verdi
authors.forename: Belgin
authors.initials: B
authors.lastname: Ataç
authors.forename: Füsun
authors.initials: F
authors.lastname: Öner Eyüboğlu
mesh_terms: D000368:Aged; D000403:Airway Resistance / Q000235:genetics; D000704:Analysis of Variance; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D014421:Turkey
chemical_list: C508960:TGFB1 protein, human; C439524:TNF protein, human; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha