title: Dengue fever treatment with Carica papaya leaves extracts.
abstract: The main objective of the current study is to investigate the potential of Carica papaya leaves extracts against Dengue fever in 45 year old patient bitten by carrier mosquitoes. For the treatment of Dengue fever the extract was prepared in water. 25 mL of aqueous extract of C. papaya leaves was administered to patient infected with Dengue fever twice daily i.e. morning and evening for five consecutive days. Before the extract administration the blood samples from patient were analyzed. Platelets count (PLT), White Blood Cells (WBC) and Neutrophils (NEUT) decreased from 176×10(3)/µL, 8.10×10(3)/µL, 84.0% to 55×10(3)/µL, 3.7×10(3)/µL and 46.0%. Subsequently, the blood samples were rechecked after the administration of leaves extract. It was observed that the PLT count increased from 55×10(3)/µL to 168×10(3)/µL, WBC from 3.7×10(3)/µL to 7.7×10(3)/µL and NEUT from 46.0% to 78.3%. From the patient feelings and blood reports it showed that Carica papaya leaves aqueous extract exhibited potential activity against Dengue fever. Furthermore, the different parts of this valuable specie can be further used as a strong natural candidate against viral diseases.
authors.affiliation: Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan ; Nuclear Institute for Food and Agriculture (NIFA) Tarnab, Peshawar 25000, Pakistan.
authors.forename: Nisar
authors.initials: N
authors.lastname: Ahmad
authors.forename: Hina
authors.initials: H
authors.lastname: Fazal
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ayaz
authors.forename: Bilal Haider
authors.initials: BH
authors.lastname: Abbasi
authors.forename: Ijaz
authors.initials: I
authors.lastname: Mohammad
authors.forename: Lubna
authors.initials: L
authors.lastname: Fazal
mesh_terms: D000998:Antiviral Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D029441:Carica / Q000737:chemistry*; D003715:Dengue / Q000188:drug therapy*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D010976:Platelet Count; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts
keywords: Carica papaya; Dengue fever; Leaves extracts; Platelets; Potential activity