title: Chromatin reorganization through mitosis.
abstract: Chromosome condensation is one of the major chromatin-remodeling events that occur during cell division. The changes in chromatin compaction and higher-order structure organization are essential requisites for ensuring a faithful transmission of the replicated genome to daughter cells. Although the observation of mitotic chromosome condensation has fascinated Scientists for a century, we are still far away from understanding how the process works from a molecular point of view. In this chapter, I will analyze our current understanding of chromatin condensation during mitosis with particular attention to the major molecular players that trigger and maintain this particular chromatin conformation. However, within the chromosome, not all regions of the chromatin are organized in the same manner. I will address separately the structure and functions of particular chromatin domains such as the centromere. Finally, the transition of the chromatin through mitosis represents just an interlude for gene expression between two cell cycles. How the transcriptional information that governs cell linage identity is transmitted from mother to daughter represents a big and interesting question. I will present how cells take care of the aspect ensuring that mitotic chromosome condensation and the block of transcription does not wipe out the cell identity.
authors.affiliation: Heinz Wolff Building, Brunel University, Uxbridge, United Kingdom. Paola.Vagnarelli@brunel.ac.uk
authors.forename: Paola
authors.initials: P
authors.lastname: Vagnarelli
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry / Q000378:metabolism; D002875:Chromosomes / Q000737:chemistry / Q000378:metabolism*; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008938:Mitosis
chemical_list: D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D006657:Histones