title: Iron-catalyzed oxidative C(3)-H functionalization of amines.
abstract: Fe-catalyzed direct dehydrogenative C(3)-functionalization of tertiary arylamines was developed via activation of the sp(3) C(3)-H bond. The reaction is applicable to both cyclic and acyclic amines. The key process is the catalytic desaturative enamine formation from tertiary amines and position-selective C-C bond formation (addition to nitro olefins) at the β-carbon. Products can be converted to versatile and unique nitrogen-containing molecules.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Takasu
authors.forename: Kounosuke
authors.initials: K
authors.lastname: Oisaki
authors.forename: Motomu
authors.initials: M
authors.lastname: Kanai
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D002244:Carbon; D007501:Iron; D009584:Nitrogen