title: Canine distemper virus associated with a lethal outbreak in monkeys can readily adapt to use human receptors.
abstract: A canine distemper virus (CDV) strain, CYN07-dV, associated with a lethal outbreak in monkeys, used human signaling lymphocyte activation molecule as a receptor only poorly but readily adapted to use it following a P541S substitution in the hemagglutinin protein. Since CYN07-dV had an intrinsic ability to use human nectin-4, the adapted virus became able to use both human immune and epithelial cell receptors, as well as monkey and canine ones, suggesting that CDV can potentially infect humans.
authors.affiliation: Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Sakai
authors.forename: Tomoki
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Fumio
authors.initials: F
authors.lastname: Seki
authors.forename: Shuetsu
authors.initials: S
authors.lastname: Fukushi
authors.forename: Maino
authors.initials: M
authors.lastname: Tahara
authors.forename: Noriyo
authors.initials: N
authors.lastname: Nagata
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ami
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mizutani
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kurane
authors.forename: Ryoji
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: Hideki
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Saijo
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Komase
authors.forename: Shigeru
authors.initials: S
authors.lastname: Morikawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Takeda
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D019943:Amino Acid Substitution; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002522:Chlorocebus aethiops; D004196:Disease Outbreaks; D004216:Distemper / Q000453:epidemiology / Q000821:virology; D004217:Distemper Virus, Canine / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D004285:Dogs; D004847:Epithelial Cells / Q000378:metabolism / Q000821:virology; D006389:Hemagglutinins, Viral / Q000235:genetics; D006801:Humans; D008251:Macaca / Q000821:virology*; D008992:Monkey Diseases / Q000453:epidemiology / Q000401:mortality / Q000821:virology*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D014709:Vero Cells; D000075983:Nectins
chemical_list: D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D006389:Hemagglutinins, Viral; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; C442228:NECTIN4 protein, human; D000075983:Nectins