title: Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies.
abstract: BACKGROUND
  Structural imaging studies demonstrate brain tissue abnormalities in eating disorders, yet a quantitative analysis has not been done.
  
  
  METHODS
  In global and regional meta-analyses of 9 voxel-based morphometry (VBM) studies, with a total of 228 eating disorder participants (currently ill with anorexia nervosa), and 240 age-matched healthy controls, we compare brain volumes using global and regional analyses.
  
  
  RESULTS
  Anorexia nervosa (AN) patients have global reductions in gray (effect size = -0.66) and white matter (effect size = -0.74) and increased cerebrospinal fluid (effect size = 0.98) and have regional decreases in left hypothalamus, left inferior parietal lobe, right lentiform nucleus and right caudate, and no significant increases. No significant difference in hemispheric lateralization was found.
  
  
  CONCLUSIONS
  Global and regional meta-analyses suggest that excessive restrained eating as found in those with anorexia nervosa coincides with structural brain changes analogous to clinical symptoms.
authors.affiliation: Department of Neuroscience, Uppsala University, Box 593, Husargatan 3, Uppsala, Sweden.
authors.forename: Olga E
authors.initials: OE
authors.lastname: Titova
authors.forename: Olof C
authors.initials: OC
authors.lastname: Hjorth
authors.forename: Helgi B
authors.initials: HB
authors.lastname: Schiöth
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Brooks
mesh_terms: D000856:Anorexia Nervosa / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D006801:Humans; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D036421:Nerve Fibers, Unmyelinated / Q000473:pathology*; D009929:Organ Size