title: Nuclear retention of the transcription factor NLP7 orchestrates the early response to nitrate in plants.
abstract: Nitrate is both an important nutrient and a signalling molecule for plants. Although several components of the nitrate signalling pathway have been identified, their hierarchical organization remains unclear. Here we show that the localization of NLP7, a member of the RWP-RK transcription factor family, is regulated by nitrate via a nuclear retention mechanism. Genome-wide analyses revealed that NLP7 binds and modulates a majority of known nitrate signalling and assimilation genes. Our findings indicate that plants, like fungi and mammals, rely on similar nuclear retention mechanisms to instantaneously respond to the availability of key nutrients.
authors.affiliation: Institut National de la Recherche Agronomique (INRA), UMR1318, Institut Jean-Pierre Bourgin, Saclay Plant Sciences, Versailles, France.
authors.forename: Chloé
authors.initials: C
authors.lastname: Marchive
authors.forename: François
authors.initials: F
authors.lastname: Roudier
authors.forename: Loren
authors.initials: L
authors.lastname: Castaings
authors.forename: Virginie
authors.initials: V
authors.lastname: Bréhaut
authors.forename: Eddy
authors.initials: E
authors.lastname: Blondet
authors.forename: Vincent
authors.initials: V
authors.lastname: Colot
authors.forename: Christian
authors.initials: C
authors.lastname: Meyer
authors.forename: Anne
authors.initials: A
authors.lastname: Krapp
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant; D009566:Nitrates / Q000378:metabolism*; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D009566:Nitrates; D014157:Transcription Factors