title: Pharmacological treatment of paraphilias.
abstract: BACKGROUND
  The psychiatrist's main role is to provide care to the paraphilic patient and to reduce personal distress. However, in cases of paraphilia associated with sexual offences, reducing paraphilic behavior is critical in an approach to preventing sexual violence and reducing victimization. This review will focus on this specific population.
  
  
  METHODS
  We discuss the recently published recommendations for the treatment of paraphilias of the World Federation of Societies of Biological Psychiatry which were based on a review of the available literature about pharmacological treatment of paraphilias (1970-2010).
  
  
  CONCLUSIONS
  Antiandrogens, and mostly GnRH analogues, significantly reduce the intensity and frequency of deviant sexual arousal and behavior, although informed consent is necessary in all cases. GnRH analogue treatment constitutes the most promising treatment for sex offenders at high risk of sexual violence, such as pedophiles or serial rapists. SSRIs remain an interesting option in adolescents, in patients with depressive or OCD disorders, or in mild paraphilias such as exhibitionism. Pharmacological interventions should be part of a more comprehensive treatment plan including psychotherapy and, in most cases, behavior therapy.
authors.affiliation: Psychiatric Department, University Hospital Ch. Nicolle, INSERM U 614, Rouen, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Thibaut
mesh_terms: D000293:Adolescent; D000328:Adult; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006801:Humans; D010262:Paraphilic Disorders / Q000188:drug therapy*; D017410:Practice Guidelines as Topic / Q000592:standards*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012742:Sex Offenses / Q000517:prevention & control*
chemical_list: D007987:Gonadotropin-Releasing Hormone; D017367:Selective Serotonin Reuptake Inhibitors