title: [Clinical manifestation and autoantibody profile in 123 patients with primary biliary cirrhosis].
abstract: OBJECTIVE
  To investigate the autoantibody profile and its clinical implication in the patients with primary biliary cirrhosis.
  
  
  METHODS
  During the period of 2008 to 2010,123 patients with primary biliary cirrhosis (PBC) in our hospital were enrolled in this study, of whom, 70 patients were with cirrhosis and 53 without cirrhosis, The autoantibody profile was tested for each patient by using immunoblotting and indirect immunofluorescence.
  
  
  RESULTS
  Of the 123 PBC patients with liver cirrhosis, 49% were positive with serum ANA positive; 47%, 51%, 54%, 31% and 49% were positive with serum anti-nuclear antibodies (ANA), anti-mitochondrial antibodies-M2 (AMA-M2), anti-promyelocytic leukemia (anti-PML), anti-sp100 antibodies (anti-sp100), anti-Ro-52 antibody (anti-52KD), respectively. By contrast, of the PBC patients without liver cirrhosis, only 38%, 37%, 51%, 60%, 30% and 51% were positive with serum ANA, AMA, AMA-M2, anti-PML, anti-sp100 and anti-52KD, respectively.There was the statistical difference between the two groups. In addition, it was also found that the anti-gp210 antibody positive group had a higher Mayo risk score,lower serum albumin and severe cholestasis and impaired liver function when compared with anti-gp210 antibody negative patients.
  
  
  CONCLUSIONS
  Our data indicate that serum AMA is helpful for early diagnosis of PBC, and in particular, serum ANA positivity can help make a diagnosis for the AMA-negative patients. These indicate that anti-gp210 antibodies appear in the late course of PBC.Anti-gp210 positive PBC patients have more severe cholestasis and liver dysfunction.
authors.affiliation: Medical School of Chinese PLA, Bejing 100853, China; Chinese PLA 302 Hospital, Bejing 100039, China.
authors.forename: Hong-hong
authors.initials: HH
authors.lastname: Liu
authors.forename: Jun-liang
authors.initials: JL
authors.lastname: Fu
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Sheng-qiang
authors.initials: SQ
authors.lastname: Luo
authors.forename: Zhen-wen
authors.initials: ZW
authors.lastname: Liu
authors.forename: Fu-sheng
authors.initials: FS
authors.lastname: Wang
mesh_terms: D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000276:immunology*; D028861:Nuclear Pore Complex Proteins / Q000276:immunology; D012189:Retrospective Studies
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; C063865:NUP210 protein, human; D028861:Nuclear Pore Complex Proteins