title: Tissue-engineered cultured periosteum sheet application to treat infrabony defects: case series and 5-year results.
abstract: One-year data after autologous grafting of infrabony periodontal defects with human cultured periosteum sheets in combination with platelet-rich plasma and hydroxyapatite granules have shown favorable clinical and radiographic results. A 5-year follow-up evaluation of 22 selected patients indicated that treated infrabony defects remained stable. Radiographically, there was an increase in osseous radiopacity and bone trabeculation suggesting further bone maturation. This novel tissue-engineered periodontal treatment approach has resulted in significant clinical improvement, and defects remained stable after 5 years.
authors.affiliation: Department of Oral Biological Science, Division of Periodontology, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan. okuda@dent.niigata-u.ac.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okuda
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kawase
authors.forename: Masaki
authors.initials: M
authors.lastname: Nagata
authors.forename: Kanoko
authors.initials: K
authors.lastname: Yamamiya
authors.forename: Koh
authors.initials: K
authors.lastname: Nakata
authors.forename: Larry F
authors.initials: LF
authors.lastname: Wolff
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Yoshie
mesh_terms: D016301:Alveolar Bone Loss / Q000145:classification / Q000000981:diagnostic imaging / Q000601:surgery*; D064592:Autografts / Q000637:transplantation*; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use; D018929:Cell Culture Techniques; D055113:Chronic Periodontitis / Q000145:classification / Q000601:surgery; D003777:Dental Prophylaxis / Q000379:methods; D012534:Dental Scaling / Q000379:methods; D017886:Durapatite / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009910:Oral Hygiene / Q000193:education; D010349:Patient Compliance; D017622:Periodontal Attachment Loss / Q000145:classification / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification / Q000601:surgery; D010521:Periosteum / Q000637:transplantation*; D053657:Platelet-Rich Plasma / Q000502:physiology; D011859:Radiography; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D018786:Bone Substitutes; D017886:Durapatite