title: Sarmentosumols A to F, new mono- and dimeric alkenylphenols from Piper sarmentosum.
abstract: Two new mono- and four new dimeric alkenylphenols, namely sarmentosumols A to F (1-6), were isolated from the aerial parts of Piper sarmentosum. The structures of these compounds were determined through a detailed analysis of NMR and MS data. Their antimicrobial activity against Escherichia coli, Staphyloccocus aureus, and Candida albicans, and their cytotoxic activity against human myeloid leukemia (K562) and human lung adenocarcinoma (A549) cell lines were also evaluated. Except for sarmentosumol A (1), whose MIC on S. aureus was reported to be 7.0 µg/mL, none of the other newly discovered compounds exhibited antimicrobial property. The studied compounds did not possess any cytotoxic property.
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
authors.forename: Shi-Xian
authors.initials: SX
authors.lastname: Yang
authors.forename: Qian-Yun
authors.initials: QY
authors.lastname: Sun
authors.forename: Fu-Mei
authors.initials: FM
authors.lastname: Yang
authors.forename: Guang-Wan
authors.initials: GW
authors.lastname: Hu
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Luo
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Long
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D019281:Dimerization; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031701:Piper / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000890:Anti-Infective Agents; D010636:Phenols