title: Measurement of brain oxygenation changes using dynamic T(1)-weighted imaging.
abstract: Magnetic resonance imaging (MRI) has proven useful in evaluating oxygenation in several types of tissue and blood. This study evaluates brain tissue oxygenation changes between normoxia and hyperoxia in healthy subjects using dynamic T1 and T2*-weighted imaging sequences. The change in FiO2 induced by hyperoxia caused a significant decrease in T1. A model to determine changes in tissue oxygen tension from the T1-weighted MRI signal is presented based on previous findings that T1 is sensitive to oxygen tension whereas T2* is sensitive to blood saturation. The two sequences produce results with different regional and temporal dynamics. These differences combined with results from simulations of the T1 signal intensities, indicate an increase in extravascular oxygen tension during hyperoxia. This study concludes that T1 and T2* responses to FiO2 serve as independent biomarkers of oxygen physiology in the brain with a potential to provide quantitative information on tissue oxygenation.
authors.affiliation: Functional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Glostrup Hospital, 57 Ndr. Ringvej, DK-2600 Glostrup, Denmark. bryan.haddock@regionh.dk
authors.forename: Bryan
authors.initials: B
authors.lastname: Haddock
authors.forename: Henrik B W
authors.initials: HB
authors.lastname: Larsson
authors.forename: Adam E
authors.initials: AE
authors.lastname: Hansen
authors.forename: Egill
authors.initials: E
authors.lastname: Rostrup
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply*; D005260:Female; D006801:Humans; D018496:Hyperoxia / Q000097:blood*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000097:blood*; D055815:Young Adult
chemical_list: D010100:Oxygen