title: Oxidation of bisphenol A by permanganate: reaction kinetics and removal of estrogenic activity.
abstract: The kinetics for reaction between bisphenol A (BPA) and permanganate was examined over pH range of 5.0-9.9 and the estrogenic activity of aqueous BPA solution after oxidation was assessed by yeast two-hybrid assay. Reaction kinetics follows the second-order rate law, with the apparent second-order rate constant of 15.1 ± 1.1 M(-1)s(-1) at pH 6.0 and 25°C and the activation energy of 48.7 kJ/mol. The kinetics exhibits pH dependency and the specific rate constants related to speciation of BPA are 50 ± 28 M(-1)s(-1), 9.6 (±0.6) × 10(3) M(-1)s(-1) and 1.4 (±0.1) × 10(4) M(-1)s(-1) for BPA, BPA(-) and BPA(2-), respectively. The results of the estrogenic/antiestrogenic activity test show that there is a hysteresis for the removal of estrogenic activity of aqueous BPA solution at pH 7.3. Removal of BPA is completed in 10 min, but complete removal of estrogenic activity requires a further 20 min.
authors.affiliation: State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Yang
authors.forename: Gang
authors.initials: G
authors.lastname: Wen
authors.forename: Ji
authors.initials: J
authors.lastname: Zhao
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Shao
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
mesh_terms: D001559:Benzhydryl Compounds / Q000737:chemistry*; D052244:Endocrine Disruptors / Q000737:chemistry*; D004968:Estrogens, Non-Steroidal / Q000737:chemistry*; D007700:Kinetics; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry*; D011196:Potassium Permanganate / Q000737:chemistry*; D013696:Temperature; D020798:Two-Hybrid System Techniques; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D011196:Potassium Permanganate; C006780:bisphenol A; D000098826:Bisphenol A Compounds