title: SLC1A2 variant associated with essential tremor but not Parkinson disease in Chinese subjects.
abstract: Essential tremor (ET) is characterized by postural and action tremor.(1-3) A genome-wide association study (GWAS) identified a LINGO1 gene variant to be associated with ET.(4) Subsequent GWAS further identified an intronic variant (rs3794087) of the main glial glutamate transporter (SLC1A2) gene to be associated with ET with an odds ratio (OR) of approximately 1.4.(5) We conducted a case-control study to examine the SLC1A2 gene variant in an Asian cohort of ET. In addition, we also investigated the variant in patients with Parkinson disease (PD) because the GWAS LINGO1 variant has been implicated in both ET and PD and etiologic links between the conditions have been suggested.(6.)
authors.affiliation: Department of Neurology, Singapore General Hospital, Singapore.
authors.forename: Eng-King
authors.initials: EK
authors.lastname: Tan
authors.forename: Jia-Nee
authors.initials: JN
authors.lastname: Foo
authors.forename: Louis
authors.initials: L
authors.lastname: Tan
authors.forename: Wing-Lok
authors.initials: WL
authors.lastname: Au
authors.forename: Kumar M
authors.initials: KM
authors.lastname: Prakash
authors.forename: Ebonne
authors.initials: E
authors.lastname: Ng
authors.forename: M Kamran
authors.initials: MK
authors.lastname: Ikram
authors.forename: Tien-Yin
authors.initials: TY
authors.lastname: Wong
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020329:Essential Tremor / Q000235:genetics*; D027342:Excitatory Amino Acid Transporter 2; D005260:Female; D055106:Genome-Wide Association Study; D050491:Glutamate Plasma Membrane Transport Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D027342:Excitatory Amino Acid Transporter 2; D050491:Glutamate Plasma Membrane Transport Proteins; C493397:SLC1A2 protein, human