title: Analytical and bioanalytical technologies for characterizing antibody-drug conjugates.
abstract: Antibody-drug conjugates (ADCs) require multiple assays for analytical and bioanalytical characterization due to their heterogeneous and dynamic nature. These assays can help address questions from the drug-loading distribution following conjugation to exposure-response relationships after dosing in vivo. This review describes new assay technologies that have been developed for physiochemical characterization and determination of pharmacokinetic parameters of ADCs.
authors.affiliation: Seattle Genetics, Inc., 21823 30th Drive SE, Bothell, WA 98021, United States. SAlley@seagen.com
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Alley
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Anderson
mesh_terms: D000818:Animals; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D006801:Humans; D018796:Immunoconjugates / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*
chemical_list: D018796:Immunoconjugates; D004364:Pharmaceutical Preparations