title: Rhenium complexes with visible-light-induced anticancer activity.
abstract: Shedding light on the matter: Rhenium(I) indolato complexes with highly potent visible-light-triggered antiproliferative activity (complex 1: EC50 light=0.1 μM vs EC50 dark=100 μM) in 2D- and 3D-organized cancer cells are reported and can be traced back to an efficient generation of singlet oxygen, causing rapid morphological changes and an induction of apoptosis.
authors.affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Marburg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Kastl
authors.forename: Sandra
authors.initials: S
authors.lastname: Dieckmann
authors.forename: Kathrin
authors.initials: K
authors.lastname: Wähler
authors.forename: Timo
authors.initials: T
authors.lastname: Völker
authors.forename: Lena
authors.initials: L
authors.lastname: Kastl
authors.forename: Anna Lena
authors.initials: AL
authors.lastname: Merkel
authors.forename: Adina
authors.initials: A
authors.lastname: Vultur
authors.forename: Batool
authors.initials: B
authors.lastname: Shannan
authors.forename: Klaus
authors.initials: K
authors.lastname: Harms
authors.forename: Matthias
authors.initials: M
authors.lastname: Ocker
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Parak
authors.forename: Meenhard
authors.initials: M
authors.lastname: Herlyn
authors.forename: Eric
authors.initials: E
authors.lastname: Meggers
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008027:Light; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012211:Rhenium / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D012211:Rhenium