title: Urinary levels of N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA), an acrylamide metabolite, in Korean children and their association with food consumption.
abstract: Acrylamide (AA), a probable human carcinogen, is present in high-temperature-processed foods, and has frequently been detected in humans worldwide. In the present study, the levels of a major AA metabolite, N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA) were measured in urine samples collected in two separate events with 3d interval from Korean children (n=31, 10-13 years old), and their diets were surveyed for 4d period prior to the second urine sampling. Daily AA intake was estimated from AAMA urinary levels and the influence of food consumption on urinary AAMA levels was investigated. The concentrations of metabolite AAMA in urine ranged between 15.4 and 196.3 ng/mL, with a median level of 68.1 ng/mL, and the levels varied by day considerably even in a given child. Children who were exposed to environmental smoke at home exhibited significantly higher levels of AAMA in urine, suggesting the importance of passive smoking as a source of AA exposure among children. Median (95th percentile) values of daily AA intake in Korean children were 1.04 (2.47)μg/kgbodyweight/day, which is higher than those reported elsewhere. After adjustment for gender, body mass index, and smoking status of family members, the consumptions of cracker and chocolate were identified to be significantly associated with the concentrations of AAMA in urine. The result of this study will provide information useful for developing public health and safety management for AA.
authors.affiliation: School of Public Health, Seoul National University, Seoul, 151-742, Republic of Korea.
authors.forename: Kyunghee
authors.initials: K
authors.lastname: Ji
authors.forename: Sungeun
authors.initials: S
authors.lastname: Kang
authors.forename: Gowoon
authors.initials: G
authors.lastname: Lee
authors.forename: Saeram
authors.initials: S
authors.lastname: Lee
authors.forename: Areum
authors.initials: A
authors.lastname: Jo
authors.forename: Kyunghee
authors.initials: K
authors.lastname: Kwak
authors.forename: Dohyung
authors.initials: D
authors.lastname: Kim
authors.forename: Dohyun
authors.initials: D
authors.lastname: Kho
authors.forename: Sangwoo
authors.initials: S
authors.lastname: Lee
authors.forename: Sunmi
authors.initials: S
authors.lastname: Kim
authors.forename: Sungkyoon
authors.initials: S
authors.lastname: Kim
authors.forename: Yuh-Fang
authors.initials: YF
authors.lastname: Hiuang
authors.forename: Kuen-Yuh
authors.initials: KY
authors.lastname: Wu
authors.forename: Kyungho
authors.initials: K
authors.lastname: Choi
mesh_terms: D000111:Acetylcysteine / Q000031:analogs & derivatives* / Q000652:urine; D020106:Acrylamide / Q000378:metabolism*; D000293:Adolescent; D002648:Child; D004034:Diet Surveys; D004435:Eating; D004784:Environmental Monitoring; D005260:Female; D005506:Food Contamination; D006801:Humans; D008297:Male; D056910:Republic of Korea; D011795:Surveys and Questionnaires
chemical_list: C569465:N-acetyl-S-(2-carbamoylethyl)cysteine; D020106:Acrylamide; D000111:Acetylcysteine