title: QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat population.
abstract: OBJECTIVE
  Individual differences in macronutrient selection, particularly fat and carbohydrate, and associated body weight gain are partly inherited as polygenic traits, but the potential genetic pathways are unknown. To give an overview of the Quantitative Trait Loci (QTLs) and candidate gene pathways influencing these differences in rat was aimed in this study.
  
  
  METHODS
  To that end, F2 rats obtained from the crossbreeding between LOU/C and Fischer 344 rat strains to diet self-selection during 3 weeks were submitted. A genome scan was conducted with microsatellite markers covering evenly the whole genome. Genotypes and phenotypes were analyzed separately in male and female F2 rats by multiple interval mapping. Then, lists of candidate genes were treated by the Ingenuity Pathway software to propose gene pathways involved in our phenotypes.
  
  
  RESULTS
  Among numerous others, a QTL on chromosome 12 that influences body weight gain, and fat and carbohydrate choices in the LOU/C x Fischer 344 F2 rat population was found. This locus contains notably the acyl-co-A dehydrogenase gene.
  
  
  CONCLUSIONS
  A strong genetic determinism and complex pathways involving numerous candidate genes and processes, notably in accordance with the metabolic theory of feeding behavior control were found.
authors.affiliation: INRA, Laboratory of Nutrition and Integrative Neurobiology, UMR 1286, 33076 Bordeaux Cedex, France; Laboratory of Nutrition and Integrative Neurobiology, University of Bordeaux, UMR 1286, 33076 Bordeaux Cedex, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Marissal-Arvy
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Diane
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Moisan
authors.forename: Christiane
authors.initials: C
authors.lastname: Larue-Achagiotis
authors.forename: Claudine
authors.initials: C
authors.lastname: Tridon
authors.forename: Daniel
authors.initials: D
authors.lastname: Tome
authors.forename: Gilles
authors.initials: G
authors.lastname: Fromentin
authors.forename: Pierre
authors.initials: P
authors.lastname: Mormède
mesh_terms: D042964:Acyl-CoA Dehydrogenase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal; D002755:Choice Behavior; D019295:Computational Biology; D003433:Crosses, Genetic; D004040:Dietary Carbohydrates / Q000009:adverse effects*; D004041:Dietary Fats / Q000009:adverse effects*; D005260:Female; D005518:Food Preferences; D008297:Male; D008954:Models, Biological; D009765:Obesity / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D040641:Quantitative Trait Loci; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D015430:Weight Gain
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D042964:Acyl-CoA Dehydrogenase