title: Mechanism of and therapeutic strategy for atrial fibrillation associated with diabetes mellitus.
abstract: Diabetes mellitus (DM) is one of the most important risk factors for atrial fibrillation (AF) and is a predictor of stroke and thromboembolism. DM may increase the incidence of AF, and when it is combined with other risk factors, the incidence of stroke and thromboembolism may also be higher; furthermore, hospitalization due to heart failure appears to increase. Maintenance of well-controlled blood glucose and low levels of HbA1c in accordance with guidelines may decrease the incidence of AF. The mechanisms of AF associated with DM are autonomic remodeling, electrical remodeling, structural remodeling, and insulin resistance. Inhibition of the renin-angiotensin system is suggested to be an upstream therapy for this type of AF. Studies have indicated that catheter ablation may be effective for AF associated with DM, restoring sinus rhythm and improving prognosis. Catheter ablation combined with hypoglycemic agents may further increase the rate of maintenance of sinus rhythm and reduce the need for reablation.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou 0086-510630, China.
authors.forename: Yubi
authors.initials: Y
authors.lastname: Lin
authors.forename: Hairui
authors.initials: H
authors.lastname: Li
authors.forename: Xianwu
authors.initials: X
authors.lastname: Lan
authors.forename: Xianghui
authors.initials: X
authors.lastname: Chen
authors.forename: Aidong
authors.initials: A
authors.lastname: Zhang
authors.forename: Zicheng
authors.initials: Z
authors.lastname: Li
mesh_terms: D001281:Atrial Fibrillation / Q000503:physiopathology* / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D003131:Combined Modality Therapy; D048909:Diabetes Complications / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007004:Hypoglycemic Agents