title: Nephrotic syndrome associated with gemcitabine use in a patient with ovarian cancer.
abstract: BACKGROUND
  Here we present a patient who developed nephrotic syndrome associated with gemcitabine use.
  
  
  METHODS
  Gemcitabine therapy was initiated following tumor recurrence in a patient with ovarian cancer, who was previously treated twice with carboplatin and paclitaxel. Radiological findings waned and tumor marker concentrations decreased after gemcitabine treatment. However, edema and ascites development was observed on the fifth treatment cycle. Laboratory results revealed increased blood urea nitrogen and creatinine levels, decreased serum albumin concentrations, and increased 24-hour urinary protein excretion. Renal biopsy findings were compatible with membranous glomerulonephritis. Gemcitabine administration was stopped and the cyclophosphamide and steroid therapy were initiated. The symptoms and findings disappeared after the cessation of gemcitabine and immunosuppressive treatment.
  
  
  CONCLUSIONS
  Gemcitabine treatment may be associated with proteinuria to the extent of nephrotic syndrome.
authors.affiliation: Mersin State Hospital Clinic Of Medical Oncology, Mersin, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Ata
authors.forename: Iclal
authors.initials: I
authors.lastname: Gürses
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kıykım
authors.forename: Ali
authors.initials: A
authors.lastname: Arıcan
keywords: gemcitabine; nephrotic syndrome; ovarian cancer