title: Beneficial effects of noni (Morinda citrifolia L.) juice on livers of high-fat dietary hamsters.
abstract: Polyphenols in noni juice (NJ) are mainly composed of phenolic acids, mainly gentisic, p-hydroxybenoic, and chlorogenic acids. To investigate the beneficial effects of NJ on the liver, hamsters were fed with two diets, normal-fat and high-fat diets. Furthermore, high-fat dietary hamsters were received distilled water, and 3, 6, and 9 mL NJ/kg BW, respectively. After a 6-week feeding period, the increased (p<0.05) sizes of liver and visceral fat in high-fat dietary hamsters compared to the control hamsters were ameliorated (p<0.05) by NJ supplementation. NJ also decreased (p<0.05) serum/liver lipids but enhanced (p<0.05) daily faecal lipid/bile acid outputs in the high-fat dietary hamsters. High-fat dietary hamsters supplemented with NJ had higher (p<0.05) liver antioxidant capacities but lowered (p<0.05) liver iNOS, COX-2, TNF-α, and IL-1β expressions, gelatinolytic levels of MMP9, and serum ALT values compared to those without NJ. Hence, NJ protects liver against a high-fat dietary habit via regulations of antioxidative and anti-inflammatory responses.
authors.affiliation: Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan.
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Lin
authors.forename: Yuan-Yen
authors.initials: YY
authors.lastname: Chang
authors.forename: Deng-Jye
authors.initials: DJ
authors.lastname: Yang
authors.forename: Bor-Show
authors.initials: BS
authors.lastname: Tzang
authors.forename: Yi-Chen
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000818:Animals; D001628:Beverages / Q000032:analysis; D006224:Cricetinae; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000009:adverse effects / Q000378:metabolism*; D005234:Fatty Liver / Q000139:chemically induced / Q000178:diet therapy* / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D032066:Morinda / Q000737:chemistry*; D052247:Nitric Oxide Synthase Type II / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress; D028321:Plant Preparations / Q000378:metabolism*; D059808:Polyphenols / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D028321:Plant Preparations; D059808:Polyphenols; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2