title: [Tumor suppressor role of chromatin-remodeling factor ARID1A].
abstract: The mammalian SWI/SNF complex is one of ATP-dependent chromatin-remodeling complexes, which plays important roles in cell proliferation, differentiation, development and tumor suppression. ARID1A (AT-rich interactive domain-containing protein 1A) is a large subunit of SWI/SNF complex, and also an ARID family member with non- sequence-specific DNA binding activity. ARID1A is a tumor suppressor gene which is frequently mutated in many cancers, such as ovarian, bladder and gastric cancers. ARID1A can suppress cell proliferation through the up-regulation of p21 and the down-regulation of E2F-responsive genes. These findings on ARID1A and its role of tumor suppression contribute to understanding the mechanism of cancer development and developing new therapy for cancer.It is introduced in the review that ARID1A basic characteristic, related to cancer development, and biological role for full understanding of ARID1A.
authors.affiliation: Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China. xiaoqiangguo123@163.com
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Guo
authors.forename: Qiao-Xia
authors.initials: QX
authors.lastname: Zhang
authors.forename: Wei-Ren
authors.initials: WR
authors.lastname: Huang
authors.forename: Xiang-Lin
authors.initials: XL
authors.lastname: Duan
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Cai
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins; D006801:Humans; D009154:Mutation; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: C112476:ARID1A protein, human; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins