title: Zhen gan xi feng decoction, a traditional chinese herbal formula, for the treatment of essential hypertension: a systematic review of randomized controlled trials.
abstract: Objectives. To assess the clinical effectiveness and adverse effects of Zhen Gan Xi Feng Decoction (ZGXFD) for essential hypertension (EH). Methods. Five major electronic databases were searched up to August 2012 to retrieve any potential randomized controlled trials designed to evaluate the clinical effectiveness of ZGXFD for EH reported in any language, with main outcome measure as blood pressure (BP). Results. Six randomized trials were included. Methodological quality of the trials was evaluated as generally low. Four trials compared prescriptions based on ZGXFD with antihypertensive drugs. Meta-analysis showed that ZGXFD was more effective in BP control and TCM syndrome and symptom differentiation (TCM-SSD) scores than antihypertensive drugs. Two trials compared the combination of modified ZGXFD plus antihypertensive drugs with antihypertensive drugs. Meta-analysis showed that there is significant beneficial effect on TCM-SSD scores. However, no significant effect on BP was found. The safety of ZGXFD is still uncertain. Conclusions. ZGXFD appears to be effective in improving blood pressure and hypertension-related symptoms for EH. However, the evidence remains weak due to poor methodological quality of the included studies. More rigorous trials are warranted to support their clinical use.
authors.affiliation: Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China.
authors.forename: Xingjiang
authors.initials: X
authors.lastname: Xiong
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Yang
authors.forename: Bo
authors.initials: B
authors.lastname: Feng
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Lian
authors.initials: L
authors.lastname: Duan
authors.forename: Ao
authors.initials: A
authors.lastname: Gao
authors.forename: Haixia
authors.initials: H
authors.lastname: Li
authors.forename: Jizheng
authors.initials: J
authors.lastname: Ma
authors.forename: Xinliang
authors.initials: X
authors.lastname: Du
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Pengqian
authors.initials: P
authors.lastname: Wang
authors.forename: Kelei
authors.initials: K
authors.lastname: Su
authors.forename: Fuyong
authors.initials: F
authors.lastname: Chu
authors.forename: Guohao
authors.initials: G
authors.lastname: Zhang
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Wang