title: Sulfation, anticoagulant and antioxidant activities of polysaccharide from green algae Enteromorpha linza.
abstract: Sulfated polysaccharides exerted potent biological property which was relative to degree of sulfation, molecular weight, substitution position and chain conformation. In present study, the polysaccharide with low molecular weight (LEP) from Enteromorpha linza was sulfated with chlorosulfuric acid in formamide. The obtained polysaccharide sulfate was selected to evaluate their antioxidant activities and the anticoagulant activity in the coagulation assays, activated partial thromboplastin time (APTT), thrombin time (TT) and prothrombin time (PT). The data obtained in vitro models indicated that high DS and moderate Mw showed the best anticoagulant and antioxidant activities.
authors.affiliation: Department of Pharmacology, Huzhou Teachers College, Huzhou 313000, China. wangxiaomei@hutc.zj.cn
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Wang
authors.forename: Zhongshan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Yao
authors.forename: Mingxing
authors.initials: M
authors.lastname: Zhao
authors.forename: Huimin
authors.initials: H
authors.lastname: Qi
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000737:chemistry* / Q000494:pharmacology; D002645:Chickens; D016166:Free Radical Scavengers; D008745:Methylation; D010314:Partial Thromboplastin Time; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology; D011517:Prothrombin Time; D017550:Spectroscopy, Fourier Transform Infrared; D013431:Sulfates; D013481:Superoxides / Q000737:chemistry; D013918:Thrombin Time; D044445:Ulva / Q000737:chemistry*
chemical_list: D000925:Anticoagulants; D016166:Free Radical Scavengers; D010936:Plant Extracts; D011134:Polysaccharides; D013431:Sulfates; D013481:Superoxides