title: Glucose-6-phosphate dehydrogenase deficiency in neonatal hyperbilirubinaemia: Hacettepe experıence.
abstract: OBJECTIVE
  The aim of this study was to investigate the prevalence of glucose-6-phospate dehydrogenase (G6PD) deficiency in newborn infants with neonatal hyperbilirubinaemia and to compare the clinical features of G6PD-deficient and G6PD-normal newborn infants.
  
  
  METHODS
  A total of 4906 term and preterm neonates with indirect hyperbilirubinaemia were retrospectively evaluated according to demographic, neonatal features, bilirubin levels, erythrocyte G6PD levels, other risk factors and treatments.
  
  
  RESULTS
  Among 4906 newborn infants with indirect hyperbilirubinaemia, 55 (1.12%) neonates were G6PD-deficient. In our study, no statistically significant difference was detected between G6PD-deficient and G6PD-normal infants in relation to the time of onset of jaundice, bilirubin levels and duration of phototherapy. However, the incidence of exchange transfusion in G6PD-deficient infants was 16.4% while it was only 3.3% in G6PD normal infants (P < 0.05).
  
  
  CONCLUSIONS
  Testing for G6PD must be ordered to all newborns who are receiving phototherapy and especially to those who are coming from the high incident geographical regions and less responsive to phototherapy.
authors.affiliation: Section of Neonatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey. htcelik@yahoo.com
authors.forename: H Tolga
authors.initials: HT
authors.lastname: Celik
authors.forename: Ceren
authors.initials: C
authors.lastname: Günbey
authors.forename: Sule
authors.initials: S
authors.lastname: Unal
authors.forename: Fatma
authors.initials: F
authors.lastname: Gümrük
authors.forename: Murat
authors.initials: M
authors.lastname: Yurdakök
mesh_terms: D001663:Bilirubin / Q000097:blood; D005260:Female; D005865:Gestational Age; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications* / Q000175:diagnosis; D006400:Hematocrit; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000209:etiology* / Q000628:therapy; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood / Q000628:therapy; D008297:Male; D010789:Phototherapy
chemical_list: D001663:Bilirubin