title: Long-term outcomes of pediatric ischemic stroke in adulthood.
abstract: This population-based study assesses the long-term impact of childhood stroke on function and independence in young adults. We undertook a cross-sectional outcome study of patients with arterial ischemic stroke and cerebral sinovenous thrombosis, beyond 18 years of age. We studied 26 patients; 21 arterial stroke, 5 cerebral sinovenous thrombosis, with 16 females. Mean age at assessment was 21.5 years, and mean follow-up time was 10.8 years. According to the modified Rankin Scale, final outcomes were 37% normal, 42% mild, 8% moderate, and 15% severe deficits. Risk factors for abnormal functional outcome included arterial ischemic stroke, presence of arteriopathy, and 1-year poststroke Pediatric Stroke Outcome Measure score ≥ 2 (P < .05). Most (77-84%) were independent in driving, relationships, and employment. Functional status at 1 year poststroke strongly predicts long-term outcome. Mental illness in one-quarter of young adults surviving childhood stroke represents an important direction for research.
authors.affiliation: Children's Stroke Program, Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada jelbers@stanford.edu.
authors.forename: Jorina
authors.initials: J
authors.lastname: Elbers
authors.affiliation: Children's Stroke Program, Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: deVeber
authors.affiliation: Department of Child Health and Evaluative Sciences, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Pontigon
authors.affiliation: Children's Stroke Program, Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
authors.forename: Mahendranath
authors.initials: M
authors.lastname: Moharir
mesh_terms: D000328:Adult; D002545:Brain Ischemia / Q000150:complications*; D018672:Community Health Planning; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D017063:Outcome Assessment, Health Care; D011237:Predictive Value of Tests; D018709:Statistics, Nonparametric; D020521:Stroke / Q000175:diagnosis* / Q000209:etiology*; D055815:Young Adult
keywords: outcome; outcome measures; stroke