title: Structure and absolute configuration of fumiquinazoline L, an alkaloid from a gorgonian-derived Scopulariopsis sp. fungus.
abstract: Fumiquinazoline L (1), an alkaloid with a heptacyclic skeleton formed via a bridging hemiaminal linkage, was isolated from a gorgonian-derived Scopulariopsis sp. fungus. The structure and absolute configuration of the new compound were identified by comprehensive spectroscopic data and X-ray diffraction analysis. During acid hydrolysis of 1, the isomerization of the valine residue was observed and also studied in different conditions. Fumiquinazoline L (1) showed no cytotoxic or antibacterial activities.
authors.affiliation: Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
authors.forename: Chang-Lun
authors.initials: CL
authors.lastname: Shao
authors.forename: Ru-Fang
authors.initials: RF
authors.lastname: Xu
authors.forename: Mei-Yan
authors.initials: MY
authors.lastname: Wei
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: She
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D037421:Anthozoa / Q000382:microbiology*; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D060645:Scopulariopsis / Q000737:chemistry*
chemical_list: D000470:Alkaloids; C582804:fumiquinazoline L