title: Pd-catalyzed diastereoselective allylation of aldehydes with 3-bromomethyl-5H-furan-2-one: stereoselective synthesis of β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones with a syn configuration.
abstract: An efficient and diastereoselective Pd-catalyzed method of allylation of aldehydes with 3-bromomethyl-5H-furan-2-one is described. The proposed method allows the synthesis of β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones with a syn relative configuration for the first time.
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Fuhai
authors.initials: F
authors.lastname: Zhang
authors.forename: Yanxin
authors.initials: Y
authors.lastname: Yang
authors.forename: Longguan
authors.initials: L
authors.lastname: Xie
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Xu
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C574254:3-bromomethyl-5H-furan-2-one; D000447:Aldehydes; D005663:Furans; C014096:alpha-methylene gamma-butyrolactone; D010165:Palladium; D015107:4-Butyrolactone