title: Pulmonary sclerosing hemangioma: a unique epithelial neoplasm of the lung (report of 26 cases).
abstract: BACKGROUND
  Pulmonary sclerosing hemangioma (SH) is an uncommon tumor. The aim of this study was to identify the origin of pulmonary SH and summarize its clinicopathologic features.
  
  
  METHODS
  Data of 26 cases of pulmonary SH were collected and reviewed, including their clinical symptoms, chest radiological examinations, treatments, and pathological findings.
  
  
  RESULTS
  Female patients of pulmonary SH were markedly frequent (n=23, 88.46%). Solitary mass or nodule in the lung fields was the most common manifestation (n=24, 92.31%), especially in the right middle lobe (n=9, 34.62%). There were two kinds of tumor cells: lining cells and round cells. All tumors contained a mixture of papillary, solid, sclerotic, and hemorrhagic patterns. Immunohistochemistry with a variable number of antibodies was performed for some cases. All of the detected specimens revealed strong reaction of lining cells with epithelial markers, such as thyroid transcription factor-1 (TTF-1), epithelial membrane antigen (EMA), cytokeratin (CK), pancytokeratin (PCK), and cytokeratin 7 (CK-7), while round cells were positive with TTF-1 and EMA. Until the end of last contact, none of the patients died or suffered from the recurrence of the disease after surgical treatment.
  
  
  CONCLUSIONS
  Pulmonary SH is a unique neoplasm of the lung with a characteristic solitary mass or nodule. Pulmonary epithelium might be the primary origin of the tumor cells.
authors.affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University, No, 37, Guo Xue Street, Chengdu, Sichuan 610041, China.
authors.forename: Bojiang
authors.initials: B
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Yidan
authors.initials: Y
authors.lastname: Cao
authors.forename: Xin
authors.initials: X
authors.lastname: He
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.forename: Man
authors.initials: M
authors.lastname: Luo
authors.forename: Shangfu
authors.initials: S
authors.lastname: Zhang
authors.forename: Weimin
authors.initials: W
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology*; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D047868:Pulmonary Sclerosing Hemangioma / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor