title: Multicomponent solvent-free synthesis of benzimidazolyl imidazo[1,2-a]-pyridine under microwave irradiation.
abstract: A novel one-pot, three-component reaction employing variously substituted benzimidazole-linked amino pyridines, aldehydes, and isonitriles catalyzed by scandium(III) triflate under solvent-free conditions were accomplished. This new synthetic methodology facilitates the rapid generation of intricate molecular frameworks in three-dimensional fashion leading to benzimidazole-imidazo[1,2-a] pyridines. This approach is envisioned as an environmentally benign process and a simple operation to the biological interesting compounds. The present synthetic sequence permits the introduction of three points of structural diversity to expand chemical space with high purity and excellent yields.
authors.affiliation: Laboratory of Combinatorial Drug Design, Department of Applied Chemistry, National Chiao-Tung University, Hsinchu 300-10, Taiwan.
authors.forename: Barnali
authors.initials: B
authors.lastname: Maiti
authors.forename: Kaushik
authors.initials: K
authors.lastname: Chanda
authors.forename: Manikandan
authors.initials: M
authors.lastname: Selvaraju
authors.forename: Chih-Chung
authors.initials: CC
authors.lastname: Tseng
authors.forename: Chung-Ming
authors.initials: CM
authors.lastname: Sun
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D055808:Drug Discovery; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D012538:Scandium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001562:Benzimidazoles; D007093:Imidazoles; D008698:Mesylates; D011725:Pyridines; C436603:scandium triflate; D012538:Scandium