title: Osteoporosis as a risk factor for the recurrence of benign paroxysmal positional vertigo.
abstract: OBJECTIVE
  Benign paroxysmal positional vertigo (BPPV) frequently occurs in females over 50 years old, suggesting that a postmenopausal decrease in estrogen secretion might be involved in its onset. An estrogen deficiency is generally known to cause osteoporosis through a reduction in bone mass. This study was designed to investigate a clinical association between idiopathic BPPV and osteoporosis.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  We measured the bone mineral density (BMD) at the lumbar vertebrae in 61 patients with idiopathic BPPV who were postmenopausal women over 50 years old using dual-energy x-ray absorptiometry. After being treated with the canalith repositioning maneuver, the patients were followed up for at least 1 year.
  
  
  RESULTS
  Our results showed that the incidence of osteoporosis in patients with BPPV was 26.2%, which was similar to those observed in epidemiological surveys conducted in Japan. However, we found that in BPPV patients with osteoporosis, the incidence of recurrence was 56.3%, which was significantly higher than that observed in patients with normal bone mineral density (16.1%). Furthermore, the frequency of BPPV recurrence increased as BMD decreased.
  
  
  CONCLUSIONS
  These results suggest that osteoporosis is a risk factor for BPPV recurrence. The prognosis of BPPV might be clinically predicted by BMD reduction.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Nara Medical University School of Medicine, Nara, Japan; and the.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Shiho
authors.initials: S
authors.lastname: Shirota
authors.forename: Yachiyo
authors.initials: Y
authors.lastname: Sawai
authors.forename: Takayuki
authors.initials: T
authors.lastname: Murai
authors.forename: Nobuya
authors.initials: N
authors.lastname: Fujita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hosoi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D065635:Benign Paroxysmal Positional Vertigo; D015519:Bone Density; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications*; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors; D014717:Vertigo / Q000453:epidemiology / Q000209:etiology*
keywords: Benign paroxysmal positional vertigo; bone mineral density; osteoporosis; otolith; recurrence