title: Novel porous Al2O3-SiO2-TiO2 bone grafting materials: formation and characterization.
abstract: The present article deals with the development of 3D porous scaffolds for bone grafting. They were prepared based on rapid fluid infiltration of Al2O3-SiO2 sol into a polyethylene non-woven fabric template structure. Titanium dioxide in concentration equal to 5 wt% was added to the Al2O3-SiO2 mixture to produce Al2O3-SiO2-TiO2 composite scaffolds. The prepared scaffolds are characterized by means of X-ray diffraction, scanning electron microscopy and three-point bending test techniques. The bioactivity of the produced bodies is discussed, including the in vitro and in vivo assessments. The produced scaffolds exhibit mean total porosity of 66.0% and three-point bending strength of 7.1 MPa. In vitro studies showed that MG-63 osteoblast-like cells attach and spread on the scaffolds surfaces. Furthermore, cells grew through the scaffolds and start to produce extra-cellular matrix. Additionally, in vivo studies revealed the ability of the porous scaffolds to regenerate bone tissue in femur defects of albino rats 5 months post surgery. Histological analysis showed that the defect is almost entirely filled with new bone. The formed bone is characterized as a mature bone. The produced bone grafts are intended to be used as bone substitute or bone filler as their degradation products caused no inflammatory effects.
authors.affiliation: 1Department of Ceramics, National Research Center, Cairo, Egypt.
authors.forename: Salma M
authors.initials: SM
authors.lastname: Naga
authors.forename: Abeer M
authors.initials: AM
authors.lastname: El-Kady
authors.forename: Hesham F
authors.initials: HF
authors.lastname: El-Maghraby
authors.forename: Mohamed
authors.initials: M
authors.lastname: Awaad
authors.forename: Rainer
authors.initials: R
authors.lastname: Detsch
authors.forename: Aldo R
authors.initials: AR
authors.lastname: Boccaccini
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D016025:Bone Transplantation; D002460:Cell Line; D008297:Male; D008855:Microscopy, Electron, Scanning; D051381:Rats; D017207:Rats, Sprague-Dawley; D012822:Silicon Dioxide / Q000737:chemistry*; D054457:Tissue Scaffolds; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; C009495:titanium dioxide; D012822:Silicon Dioxide; D014025:Titanium; D000537:Aluminum Oxide
keywords: Bone grafting; bioceramics; in vitro; in vivo; porous materials