title: Minocycline, a microglial inhibitor, reduces 'honey trap' risk in human economic exchange.
abstract: Recently, minocycline, a tetracycline antibiotic, has been reported to improve symptoms of psychiatric disorders and to facilitate sober decision-making in healthy human subjects. Here we show that minocycline also reduces the risk of the 'honey trap' during an economic exchange. Males tend to cooperate with physically attractive females without careful evaluation of their trustworthiness, resulting in betrayal by the female. In this experiment, healthy male participants made risky choices (whether or not to trust female partners, identified only by photograph, who had decided in advance to exploit the male participants). The results show that trusting behaviour in male participants significantly increased in relation to the perceived attractiveness of the female partner, but that attractiveness did not impact trusting behaviour in the minocycline group. Animal studies have shown that minocycline inhibits microglial activities. Therefore, this minocycline effect may shed new light on the unknown roles microglia play in human mental activities.
authors.affiliation: Organization for Japan-US Studies, Waseda University, 513 Waseda Tsurumaki-cho, Shinjuku-ku, Tokyo 162-0041, Japan. motokiw@gmail.com
authors.forename: Motoki
authors.initials: M
authors.lastname: Watabe
authors.forename: Takahiro A
authors.initials: TA
authors.lastname: Kato
authors.forename: Sho
authors.initials: S
authors.lastname: Tsuboi
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Hashiya
authors.forename: Akira
authors.initials: A
authors.lastname: Monji
authors.forename: Hideo
authors.initials: H
authors.lastname: Utsumi
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Kanba
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D003657:Decision Making / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D017628:Microglia / Q000187:drug effects / Q000502:physiology*; D008911:Minocycline / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D008911:Minocycline