title: Pharmacogenomics of bipolar disorder.
abstract: Bipolar disorder (BD) is a lifelong severe psychiatric condition with high morbidity, disability and excess mortality. The longitudinal clinical trajectory of BD is significantly modified by pharmacological treatment(s), both in acute and in long-term stages. However, a large proportion of BD patients have inadequate response to pharmacological treatments. Pharmacogenomic research may lead to the identification of molecular predictors of treatment response. When integrated with clinical information, pharmacogenomic findings may be used in the future to determine the probability of response/nonresponse to treatment on an individual basis. Here we present a selective review of pharmacogenomic findings in BD. In light of the evidence suggesting a genetic effect of lithium reponse in BD, we focused particularly on the pharmacogenomic literature relevant to this trait. The article contributes a detailed overview of the current status of pharmacogenomics in BD and offers a perspective on the challenges that can hinder its transition to personalized healthcare.
authors.affiliation: Laboratory of Molecular Genetics, Section of Neuroscience & Clinical Pharmacology, Department of Biomedical Sciences, Sp 8, Sestu-Monserrato, Km 0.700 CA, University of Cagliari, Cagliari, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Severino
authors.forename: Alessio
authors.initials: A
authors.lastname: Squassina
authors.forename: Marta
authors.initials: M
authors.lastname: Costa
authors.forename: Claudia
authors.initials: C
authors.lastname: Pisanu
authors.forename: Stefano
authors.initials: S
authors.lastname: Calza
authors.forename: Martin
authors.initials: M
authors.lastname: Alda
authors.forename: Maria
authors.initials: M
authors.lastname: Del Zompo
authors.forename: Mirko
authors.initials: M
authors.lastname: Manchia
mesh_terms: D000818:Animals; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D018020:Lithium Compounds / Q000627:therapeutic use; D010597:Pharmacogenetics
chemical_list: D018020:Lithium Compounds