title: Protective effects of enalapril, an angiotensin-converting enzyme inhibitor, on multiple organ damage following scald injury in rats.
abstract: The aim of this study is to investigate the effects of enalapril, an angiotensin-converting enzyme inhibitor, on multiple organ damage after scald injury. Healthy adult rats (half male and half female; 8-12 weeks old) were randomly assigned to the following treatments: sham operation, scald injury, and intraperitoneal enalapril (1, 2, and 4 mg/kg body weight) treatment after scalding. At 1, 12, and 24 H postscald, left ventricular and aortic hemodynamics were measured using a multichannel physiological recorder. Functional and pathological changes of the heart, liver, and kidney were examined by biochemical and histological methods. Compared with sham controls, untreated scalded animals showed decreased hemodynamic parameters and increased myocardial angiotensin II, serum creatine kinase heart isoenzyme, and serum cardiac troponin I and histopathological inflammation in the myocardium 12 H postscald. These hemodynamic, functional, and pathological changes were attenuated by 1 mg/kg enalapril. Enalapril reversed scald-induced elevations in aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and blood creatinine 12 H postscald, and ameliorated focal necrosis in the liver and erythrocyte cast formation in renal tubules. However, higher doses of enalapril yielded less or no improvement in organ dysfunction. Enalapril at 1 mg/kg attenuates scald-induced multiple organ damage in rats.
authors.affiliation: Institute of Burn Research of PLA, National Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, People's Republic of China.
authors.forename: Bing-Qian
authors.initials: BQ
authors.lastname: Zhang
authors.forename: Guang
authors.initials: G
authors.lastname: Wang
authors.forename: Jia-Ping
authors.initials: JP
authors.lastname: Zhang
authors.forename: Jiong-Yu
authors.initials: JY
authors.lastname: Hu
authors.forename: Rong
authors.initials: R
authors.lastname: Xiao
authors.forename: Ze-Yuan
authors.initials: ZY
authors.lastname: Lei
authors.forename: Jing
authors.initials: J
authors.lastname: Ruan
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Dang
authors.forename: Dong-Xia
authors.initials: DX
authors.lastname: Zhang
authors.forename: Xiu-Wu
authors.initials: XW
authors.lastname: Bian
authors.forename: Yue-Sheng
authors.initials: YS
authors.lastname: Huang
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002056:Burns / Q000150:complications*; D004656:Enalapril / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D009102:Multiple Organ Failure / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D009928:Organ Specificity; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D015415:Biomarkers; D004656:Enalapril; D007703:Peptidyl-Dipeptidase A