title: Ultrasonic synthesis, characterization of β-aminoketones by bismuth(III) triflate and determination of antigenotoxic properties.
abstract: Direct-type catalytic Mannich reaction for the synthesis of β-aminoketones from cyclohexanone, substituted aromatic amines and aromatic or hetero-aromatic aldehydes has been applied in water with bismuth triflate under ultrasound. Good yields of the expected β-aminoketones were obtained from available substrates, at room temperature in 1-2 hours. This study was designed to evaluate the mutagenic and antimutagenic potential of synthesized β-aminoketones compounds using Ames/Salmonella and Escherichia coli WP2 bacterial reverse mutation assay systems.
authors.affiliation: Department of Chemistry, Yildiz Technical University, Istanbul, Turkey turkcana@hotmail.com.
authors.forename: S Arda
authors.initials: SA
authors.lastname: Ozturkcan
authors.affiliation: Department of Chemistry, Yildiz Technical University, Istanbul, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Turhan
authors.affiliation: Department of Chemistry, Yildiz Technical University, Istanbul, Turkey.
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Turgut
authors.affiliation: Department of Biology, Ataturk University, Erzurum, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karadayi
authors.affiliation: Department of Biology, Ataturk University, Erzurum, Turkey.
authors.forename: Medine
authors.initials: M
authors.lastname: Gulluce
mesh_terms: D001419:Bacteria / Q000187:drug effects / Q000235:genetics; D007659:Ketones / Q000138:chemical synthesis / Q000494:pharmacology*; D008698:Mesylates / Q000737:chemistry*; D050296:Microbial Viability / Q000187:drug effects; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation / Q000187:drug effects; D020011:Protective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D013010:Sonication
chemical_list: D007659:Ketones; D008698:Mesylates; D009153:Mutagens; D020011:Protective Agents; C445789:Bi(OTf)3
keywords: antigenotoxic properties; bismuth(III) triflate; direct-type Mannich reaction; ultrasonic synthesis; β-aminoketones