title: Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.
abstract: Hypoxia is a significant feature of solid tumor cancers. Hypoxia leads to a more malignant phenotype that is resistant to chemotherapy and radiation, is more invasive and has greater metastatic potential. Hypoxia activates the hypoxia inducible factor (HIF) pathway, which mediates the biological effects of hypoxia in tissues. The HIF complex acts as a transcription factor for many genes that increase tumor survival and proliferation. To date, many HIF pathway inhibitors indirectly affect HIF but there have been no clinically approved direct HIF inhibitors. This can be attributed to the complexity of the HIF pathway, as well as to the challenges of inhibiting protein-protein interactions.
authors.affiliation: Department of Chemistry & Center for Diagnostics & Therapeutics, Georgia State University, Room 313, Petit Science Center, 100 Piedmont Ave, Atlanta, GA, 30303-3083, USA.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Burroughs
authors.affiliation: Departments of Neurosurgery and Hematology & Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kaluz
authors.affiliation: Department of Chemistry & Center for Diagnostics & Therapeutics, Georgia State University, Room 313, Petit Science Center, 100 Piedmont Ave, Atlanta, GA, 30303-3083, USA.
authors.forename: Danzhu
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Chemistry & Center for Diagnostics & Therapeutics, Georgia State University, Room 313, Petit Science Center, 100 Piedmont Ave, Atlanta, GA, 30303-3083, USA.
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.affiliation: Departments of Neurosurgery and Hematology & Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
authors.forename: Erwin G
authors.initials: EG
authors.lastname: Van Meir
authors.affiliation: Department of Chemistry & Center for Diagnostics & Therapeutics, Georgia State University, Room 313, Petit Science Center, 100 Piedmont Ave, Atlanta, GA, 30303-3083, USA.
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D015687:Cell Hypoxia / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D058990:Molecular Targeted Therapy / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D051793:Hypoxia-Inducible Factor 1