title: Effects of 25-hydroxy-cholecalciferol on the development of osteochondrosis in swine.
abstract: The principal objective of this experiment was to evaluate the effect of 25-hydroxy-cholecalciferol (25-OH-D3 ) on the development of osteochondrosis in 6- to 110-kg castrated male pigs. The growth rate and serum calcium and inorganic phosphate levels neither increased nor decreased in response to supplementation of 25-OH-D3 . However, supplemental 25-OH-D3 significantly increased serum levels of 25-OH-D3 and 1α,25-hydroxy-cholecalciferol without any influence on bone mineral density. The 25-OH-D3 -treated group had significant (P < 0.05) reduced incidence of osteochondrotic lesions compared to the control group as evidenced by macroscopically examining the articular cartilage of the distal humerus (32.4% vs. 59.3%) and distal femur (47.1% vs. 87.5%). Likewise, supplemental 25-OH-D3 significantly reduced osteochondrotic lesions over the control when histologically examining humerus (20.6% vs. 43.8%) and femur (52.9% vs. 87.5%). The results of this experiment suggested that 25-OH-D3 supplementation in pig diets had a tendency to promote normal endochondral ossification, inhibit osteochondrosis progression and possibly regenerate destroyed cartilage tissue.
authors.affiliation: Faculty of Agriculture, Niigata University, Niigata 950-2181, Japan. sugiyama@agr.niigata-u.ac.jp
authors.forename: Toshie
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Seiji
authors.initials: S
authors.lastname: Kusuhara
authors.forename: Thau Kiong
authors.initials: TK
authors.lastname: Chung
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yonekura
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Azem
authors.forename: Takehiko
authors.initials: T
authors.lastname: Hayakawa
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D001842:Bone and Bones / Q000737:chemistry / Q000473:pathology; D002112:Calcifediol / Q000097:blood / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D008297:Male; D055034:Osteochondrosis / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D010012:Osteogenesis / Q000187:drug effects; D010710:Phosphates / Q000097:blood; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*
chemical_list: D015415:Biomarkers; D010710:Phosphates; D002112:Calcifediol; D002118:Calcium