title: A bromine analogue of picoplatin: a new substance from the group of platinum-based chemotherapeutics.
abstract: A new substance, cis-amminedibromido(2-methylpyridine-κN)platinum(II), cis-[PtBr2(C6H7N)(NH3)], which is a potential platinum-based antineoplastic agent for the treatment of patients with solid tumors, has been synthesized and structurally characterized. There is one molecule in the asymmetric unit and molecules are linked via two symmetry-independent N-H···Br hydrogen bonds into zigzag chains running parallel to the c axis. C-H···Br hydrogen bonds crosslink these chains to give a layer parallel to (010). N-H···Br hydrogen bonds and π-π stacking interactions between pairs of pyridine rings stack the layers along b.
authors.affiliation: Central Laboratories, Institute of Chemical Technology, Technická 5, Prague 166 28, Czech Republic. richard.pazout@vscht.cz
authors.forename: Richard
authors.initials: R
authors.lastname: Pažout
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Maixner
authors.forename: Michaela
authors.initials: M
authors.lastname: Hrdá
authors.forename: Tereza
authors.initials: T
authors.lastname: Loužilová
authors.forename: Petr
authors.initials: P
authors.lastname: Kačer
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C110525:amminedichloro(2-methylpyridine)platinum(II)