title: Study of the biological effectiveness of a nanosilver-epidermal growth factor sustained-release carrier.
abstract: The aim of the present study was to elucidate the biological effectiveness and character of a nanosilver-epidermal growth factor (EGF) sustained-release carrier. This was synthesized using the self-assembly method and then characterized by transmission electron microscopy and UV spectrophotometry. The biological activity of the sustained release carrier was determined through cytological, bacteriological and wound-healing experiments. The results showed that the nanosilver-EGF sustained-release carrier was well dispersed with uniform particle size and that it had good antibacterial properties similar to those of nanosilver. The nanosilver-EGF sustained-release carrier is superior to EGFs in effectively promoting cell division and proliferation. The results of the wound-healing experiments provide evidence of its curative effects.
authors.affiliation: Third Xiang-Ya Hospital, Central South University, Changsha 410013, P.R. China.
authors.forename: Jian-DA
authors.initials: JD
authors.lastname: Zhou
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Wang
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Chun-Jiao
authors.initials: CJ
authors.lastname: Zhou
authors.forename: Ke
authors.initials: K
authors.lastname: Cao
authors.forename: Jin-Yan
authors.initials: JY
authors.lastname: Liu
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.forename: Feng-Hua
authors.initials: FH
authors.lastname: Chen
keywords: antibacterial; cell proliferation; epidermal growth factor; nanosilver; wound