title: Rapid improvement of canine cognitive dysfunction with immunotherapy designed for Alzheimer's disease.
abstract: Immunotherapy against amyloid-β(Aβ) may improve rodent cognitive function by reducing amyloid neuropathology and is being validated in clinical trials with positive preliminary results. However, for a complete understanding of the direct and long-term immunization responses in the aged patient, and also to avoid significant side effects, several key aspects remain to be clarified. Thus, to investigate brain Aβ clearance and Th2 responses in the elderly, and the reverse inflammatory events not found in the immunized rodent, better Alzheimer's disease (AD) models are required. In the aged familiar canine with a Cognitive Dysfunction Syndrome (CDS) we describe the rapid effectiveness and the full safety profile of a new active vaccine candidate for human AD prevention and treatment. In these aged animals, besidesa weak immune system, the antibody response activated a coordinated central and peripheral Aβ clearance, that rapidly improved their cognitive function in absence of any side effects. Our results also confirm the interest to use familiar dogs to develop innovative and reliable therapies for AD.
authors.affiliation: Medivet Pharma SL, Masies de Roda, Barcelona, Spain. neusbosch@ub.edu
authors.forename: Maria Neus
authors.initials: MN
authors.lastname: Bosch
authors.forename: Javier
authors.initials: J
authors.lastname: Gimeno-Bayón
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Rodríguez
authors.forename: Marco
authors.initials: M
authors.lastname: Pugliese
authors.forename: Nicole
authors.initials: N
authors.lastname: Mahy
mesh_terms: D000367:Age Factors; D000375:Aging / Q000276:immunology; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000150:complications* / Q000276:immunology / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D000704:Analysis of Variance; D000818:Animals; D003072:Cognition Disorders / Q000209:etiology* / Q000628:therapy*; D004195:Disease Models, Animal; D004285:Dogs; D004609:Eliminative Behavior, Animal; D019260:Expressed Emotion; D005260:Female; D006403:Hematologic Tests; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D010446:Peptide Fragments / Q000097:blood / Q000134:cerebrospinal fluid; D011817:Rabbits; D016138:Walking
chemical_list: D016229:Amyloid beta-Peptides; D007074:Immunoglobulin G; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)