title: Drug combinations against Mucor irregularis in vitro.
abstract: Combinations of terbinafine or caspofungin with amphotericin B, posaconazole, or itraconazole were studied as potential treatments against 18 isolates of Mucor irregularis in vitro. Synergism of the combinations of terbinafine with amphotericin B, posaconazole, and itraconazole against 38.9, 33.3, and 44.4% of the strains studied was observed. In contrast, synergism of the combinations of caspofungin with amphotericin B, posaconazole, and itraconazole against 99.4, 66.7, and 99.4% of the strains studied was observed. Furthermore, no antagonism was observed.
authors.affiliation: Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, Beijing, People's Republic of China.
authors.forename: Shuzhen
authors.initials: S
authors.lastname: Zhang
authors.forename: Ruoyu
authors.initials: R
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Yu
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D000077336:Caspofungin; D004338:Drug Combinations; D004357:Drug Synergism; D054714:Echinocandins / Q000494:pharmacology; D017964:Itraconazole / Q000494:pharmacology; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D009089:Mucor / Q000187:drug effects* / Q000302:isolation & purification; D009091:Mucormycosis / Q000188:drug therapy*; D009281:Naphthalenes / Q000494:pharmacology; D000077291:Terbinafine; D014230:Triazoles / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D054714:Echinocandins; D055666:Lipopeptides; D009281:Naphthalenes; D014230:Triazoles; D017964:Itraconazole; C101425:posaconazole; D000666:Amphotericin B; D000077336:Caspofungin; D000077291:Terbinafine