title: Warfarin-induced calciphylaxis successfully treated with sodium thiosulphate.
abstract: Calciphylaxis is a rare life-threatening form of skin necrosis. Although traditionally observed in patients with end-stage renal disease and/or hyperparathyroidism, calciphylaxis has also been reported to occur in 'non-traditional' patients with normal renal and parathyroid function. We report a case of warfarin-induced calciphylaxis treated successfully with sodium thiosulphate and discuss the role of Vitamin K2 as a potential therapeutic option in the management of warfarin-induced calciphylaxis.
authors.affiliation: Skin Cancer Institute, Dermatological Surgical Unit, Tauranga, New Zealand. juber.hafiji@hotmail.co.uk
authors.forename: Juber
authors.initials: J
authors.lastname: Hafiji
authors.forename: Patrick
authors.initials: P
authors.lastname: Deegan
authors.forename: Rebecca
authors.initials: R
authors.lastname: Brais
authors.forename: Paul
authors.initials: P
authors.lastname: Norris
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D000975:Antioxidants / Q000627:therapeutic use*; D002115:Calciphylaxis / Q000139:chemically induced* / Q000188:drug therapy*; D003875:Drug Eruptions / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012883:Skin Ulcer / Q000139:chemically induced / Q000628:therapy; D013885:Thiosulfates / Q000627:therapeutic use*; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D000975:Antioxidants; D013885:Thiosulfates; D014859:Warfarin; C017717:sodium thiosulfate