title: Asymmetric synthesis of trans-β-lactams by a Kinugasa reaction on water.
abstract: The asymmetric Kinugasa reaction was performed on pure water for the first time without the need for any organic co-solvents. In contrast to most asymmetric Kinugasa reactions, trans-β-lactams were obtained as the major products in good yields, enantioselectivities, and diastereoselectivities (up to 90 % yield, 98 % ee, and >99:1 d.r.). This reaction is atom-economical, environmentally friendly, and affords synthetically useful but challenging products.
authors.affiliation: Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China.
authors.forename: Zhenling
authors.initials: Z
authors.lastname: Chen
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D012997:Solvents / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*; D047090:beta-Lactams / Q000138:chemical synthesis*
chemical_list: D012997:Solvents; D047090:beta-Lactams; D014867:Water