title: Improved physical and in vitro digestion stability of a polyelectrolyte delivery system based on layer-by-layer self-assembly alginate-chitosan-coated nanoliposomes.
abstract: To improve lipid membrane stability and prevent leakage of encapsulated food ingredients, a polyelectrolyte delivery system (PDS) based on sodium alginate (AL) and chitosan (CH) coated on the surface of nanoliposomes (NLs) has been prepared and optimized using a layer-by-layer self-assembly deposition technique. Morphology and FTIR observation confirmed PDS has been successfully coated by polymers. Physical stability studies (pH and heat treatment) indicated that the outer-layer polymers could protect the core (NLs) from damage, and PDS showed more intact structure than NLs. Further enzymic digestion stability studies (particle size, surface charge, free fatty acid, and model functional component release) demonstrated that PDS could better resist lipolytic degradation and facilitate a lower level of encapsulated component release in simulated gastrointestinal conditions. This work suggested that deposition of polyelectrolyte on the surface of NLs can stabilize liposomal structure, and PDS could be developed as a formulation for delivering functional food ingredients in the gastrointestinal tract.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang 330047, Jiangxi, People's Republic of China.
authors.forename: Weilin
authors.initials: W
authors.lastname: Liu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Ti
authors.initials: T
authors.lastname: Li
authors.forename: Chengmei
authors.initials: C
authors.lastname: Liu
mesh_terms: D000464:Alginates / Q000737:chemistry*; D055598:Chemical Phenomena; D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D008081:Liposomes; D011108:Polymers; D020723:Glucuronic Acid; D048271:Chitosan