title: Goniolandrene A and B from Goniothalamus macrophyllus.
abstract: Goniothalamus macrophyllus (Blume) Hook. f. & Thoms. is a plant widely distributed in Malaysia. The aim of this study is to identify compounds from the roots of G. macrophyllus. The ground roots were extracted with aqueous methanol and partitioned sequentially with n-hexane, chloroform and butanol. Purification from this extracts afforded six compounds with two new compounds, namely goniolandrene-A (1), -B (2). The absolute configuration of goniolandrene B (2) was established by circular dichrosim. The compounds were cytotoxic against the P388 cells with IC50 values ranging from 0.42 to 160 μM. Goniothalamin (3) exhibited the highest inhibition of 0.42 μM.
authors.affiliation: MedChem Herbal Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia.
authors.forename: Norkamilah
authors.initials: N
authors.lastname: Abdullah
authors.affiliation: MedChem Herbal Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia.
authors.forename: Hamidah
authors.initials: H
authors.lastname: Sahibul-Anwar
authors.affiliation: MedChem Herbal Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia.
authors.forename: Sharinah
authors.initials: S
authors.lastname: Ideris
authors.affiliation: Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hajiochi, Tokyo 192-03, Japan.
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Hasuda
authors.affiliation: Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hajiochi, Tokyo 192-03, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Hitotsuyanagi
authors.affiliation: Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hajiochi, Tokyo 192-03, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Takeya
authors.affiliation: Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et Sang, Hôpital Kirchberg, 9 Rue Edward Steichen, 2540 Luxembourg, Luxembourg.
authors.forename: Marc
authors.initials: M
authors.lastname: Diederich
authors.affiliation: MedChem Herbal Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia. Electronic address: choo715@puncakalam.uitm.edu.my.
authors.forename: CheeYan
authors.initials: C
authors.lastname: Choo
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D054335:Goniothalamus / Q000737:chemistry*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D020128:Inhibitory Concentration 50; D007941:Leukemia P388 / Q000188:drug therapy; D008296:Malaysia; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D002867:Chromones; D006575:Heterocyclic Compounds, 3-Ring; D010936:Plant Extracts; D011753:Pyrones; C000594157:goniolandrene-A; C000594158:goniolandrene-B
keywords: Annonaceae; Biogenetic pathway; Cytotoxicity; G. macrophyllus; Goniolandrene; P388