title: Safety assessment of meat from transgenic cattle by 90-day feeding study in rats.
abstract: The study was carried out to evaluate the subchronic toxicity of meat derived from human lactoferrin gene-modified cattle in male and female Wistar rats. Rats were fed 5% or 10% transgenic meat diet, 5% or 10% conventional meat diet, or AIN93G diet for 90 days. During the study, body weight and food consumption were weighed weekly and clinical observations were conducted daily. At the end of the study, urinary examination, hematology and blood biochemistry examination, macroscopic and microscopic examinations were performed. There were no biologically significant differences in these factors between the rat groups fed transgenic meat diet and conventional meat diet. Therefore, the present 90-day rodent feeding study suggests that meat derived from the transgenic cattle is equivalent to meat from conventional cattle in use as dietary supplements.
authors.affiliation: Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, PR China. liushan78@hotmail.com
authors.forename: Shan
authors.initials: S
authors.lastname: Liu
authors.forename: Chen-Xi
authors.initials: CX
authors.lastname: Li
authors.forename: Xiao-Lian
authors.initials: XL
authors.lastname: Feng
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Wang
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Liu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhi
authors.forename: Gui-Ying
authors.initials: GY
authors.lastname: Geng
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Xu
mesh_terms: D000821:Animal Feed; D000818:Animals; D030801:Animals, Genetically Modified; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D002417:Cattle / Q000235:genetics*; D004435:Eating / Q000187:drug effects; D059022:Food Safety; D030841:Food, Genetically Modified / Q000633:toxicity*; D008297:Male; D008461:Meat Products / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D059550:Toxicity Tests, Subchronic; D016482:Urinalysis