title: Conjugation of l-NAME to prenyloxycinnamic acids improves its inhibitory effects on nitric oxide production.
abstract: A series of 10 compounds resulting from the conjugation of O-prenylated naturally occurring benzoic and cinnamic acids to l-NAME were synthesized and tested together with the corresponding unprenylated parent molecule as anti-inflammatory agents for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophages. Results indicated that the coupling between O-geranyl and O-isopentenylcinnamic acids and l-NAME led to products with an enhanced activity when compared to the parent compounds.
authors.affiliation: Dipartimento di Farmacia, Università 'G. D'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy. s.genovese@unich.it
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
authors.forename: Serena
authors.initials: S
authors.lastname: Fiorito
authors.forename: Massimo
authors.initials: M
authors.lastname: Curini
authors.forename: Mariangela
authors.initials: M
authors.lastname: Marrelli
authors.forename: Francesco
authors.initials: F
authors.lastname: Menichini
authors.forename: Filomena
authors.initials: F
authors.lastname: Conforti
mesh_terms: D000818:Animals; D002934:Cinnamates / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D019331:NG-Nitroarginine Methyl Ester / Q000737:chemistry / Q000494:pharmacology*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D013329:Structure-Activity Relationship
chemical_list: D002934:Cinnamates; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D019331:NG-Nitroarginine Methyl Ester