title: Mitochondrial myopathy: a rare cause of early-onset vocal fold atrophy.
abstract: OBJECTIVE
  We present the second published case of laryngeal involvement in mitochondrial myopathy.
  
  
  METHODS
  A patient with laryngeal involvement of mitochondrial myopathy is presented, together with a literature review.
  
  
  RESULTS
  A 41-year-old man presented with progressive breathy dysphonia. His brother had mitochondrial myopathy. Biopsy of the biceps muscle demonstrated cytochrome C oxidase-negative ragged blue fibers confirming mitochondrial myopathy. Videostroboscopy showed marked vocal fold atrophy, but subsequent injection laryngoplasty did not significantly improve the patient's voice, despite improved postoperative glottic closure.
  
  
  CONCLUSIONS
  Mitochondrial myopathy should be considered in the differential diagnosis of severe early-onset vocal fold atrophy.
authors.affiliation: Division of Laryngology and Professional Voice, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Kelly
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Bock
authors.forename: Amanda C
authors.initials: AC
authors.lastname: Peltier
authors.forename: Shin J
authors.initials: SJ
authors.lastname: Oh
authors.forename: C Gaelyn
authors.initials: CG
authors.lastname: Garrett
mesh_terms: D000328:Adult; D001284:Atrophy / Q000209:etiology; D003680:Deglutition Disorders / Q000209:etiology / Q000473:pathology*; D055154:Dysphonia / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007821:Laryngeal Muscles / Q000473:pathology* / Q000503:physiopathology; D058753:Laryngoplasty; D008297:Male; D017240:Mitochondrial Myopathies / Q000150:complications*; D014827:Vocal Cords / Q000473:pathology* / Q000503:physiopathology