title: The Relationship between Salivary Beta-2 Microglobulin and Uremia Intensity in Men with Chronic Renal Failure.
abstract: OBJECTIVE
  This study defines the relationship between salivary beta-2 microglobulin (β2-M) and intensity of uremia in male patients diagnosed with chronic renal failure (CRF).
  
  
  METHODS
  In total of 42 males were enrolled in a case-control study. There were 21 cases of CRF and 21 control cases. We collected 10cc of saliva plus 5 cc of blood from all patients to determine β2-M, blood urea nitrogen (BUN) and creatinine (Cr) levels.
  
  
  RESULTS
  There was a correlation between the level of serum BUN and salivary urea in controls and patients, which was statistically significant for controls (p=0.028).The correlation between serum and salivary Cr was 0.195 in controls (p=0.398) and 0.598 in patients (p=0.006), which was statistically significant in patients. The correlation between serum and saliva was 0.133 (p=0.566) in controls and 0.078 (p=0.737) in patients, which was not statistically significant. The correlation between serum BUN and β2-M was 0.168 (p=0.469) in the control group and 0.629 (p=0.002) in patients, which was statistically significant in patients. The correlation between serum Cr and β2-M was 0.110 (p=0.635) in the control group and 0.678 (p=0.001) in patients, which was statistically significant in patients. The correlation between serum BUN and salivary β2-M was 0.093 (p=0.0690) in controls and 0.152 (p=0.152) in patients, which was not statistically significant. The correlation between serum Cr and salivary β2-M was 0.072 (p=0.070) in the control group and 0.286 (p=0.209) in patients, which was not statistically significant in either group.
  
  
  CONCLUSIONS
  The results of the study indicated that salivary β2-M cannot be used as a noninvasive indicator to detect the severity of renal failure.
authors.affiliation: 1. Department of Oral Medicine, Dental Research Center, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Vahedi
authors.forename: Hossein
authors.initials: H
authors.lastname: Malekzadeh
authors.forename: Habib
authors.initials: H
authors.lastname: Haybar
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Soltanian
authors.forename: Shermin
authors.initials: S
authors.lastname: Abdollahzadeh
authors.forename: Hojjat
authors.initials: H
authors.lastname: Yoosefi
authors.forename: Masoud
authors.initials: M
authors.lastname: Seyedian
authors.forename: Leila
authors.initials: L
authors.lastname: Yazdanpanah
authors.forename: Abrotan
authors.initials: A
authors.lastname: Saeid
authors.forename: Maryam
authors.initials: M
authors.lastname: Shabanpour Fooladi
authors.forename: Marziyeh
authors.initials: M
authors.lastname: Ghasemi
keywords: Beta 2-Microglobulin; Chronic Renal Failure; Saliva; Uremia