title: Electrical control of kinesin-microtubule motility using a transparent functionalized-graphene substrate.
abstract: We report a new strategy to selectively localize and control microtubule translocation via electrical control of microtubules using a microfabricated channel on a functionalized-graphene electrode with high transparency and conductivity. A patterned SU-8 film acts as an insulation layer which shields the electrical field generated by the graphene underneath while the localized electric field on the exposed graphene surface guides the negatively charged microtubules. This is the first report showing that functionalized graphene can support and control microtubule motility.
authors.affiliation: Department of Biophysics and Chemical Biology, Seoul National University, Seoul, Korea.
authors.forename: Eunji
authors.initials: E
authors.lastname: Kim
authors.forename: Kyung-Eun
authors.initials: KE
authors.lastname: Byun
authors.forename: Dong Shin
authors.initials: DS
authors.lastname: Choi
authors.forename: Dong Jun
authors.initials: DJ
authors.lastname: Lee
authors.forename: Duck Hyung
authors.initials: DH
authors.lastname: Cho
authors.forename: Byung Yang
authors.initials: BY
authors.lastname: Lee
authors.forename: Heejun
authors.initials: H
authors.lastname: Yang
authors.forename: Jinseong
authors.initials: J
authors.lastname: Heo
authors.forename: Hyun-Jong
authors.initials: HJ
authors.lastname: Chung
authors.forename: Sunae
authors.initials: S
authors.lastname: Seo
authors.forename: Seunghun
authors.initials: S
authors.lastname: Hong
mesh_terms: D004553:Electric Conductivity; D004566:Electrodes; D004867:Equipment Design; D005656:Fungal Proteins / Q000378:metabolism*; D006108:Graphite / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D016547:Kinesins / Q000378:metabolism*; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D008870:Microtubules / Q000378:metabolism*; D009492:Neurospora crassa / Q000378:metabolism*
chemical_list: D005656:Fungal Proteins; D006108:Graphite; D016547:Kinesins