title: Impact of age on markers of HIV-1 disease.
abstract: Aging is a complicated process characterized by a progressive loss of homeostasis, which results in an increased vulnerability to multiple diseases. HIV-1-infected patients demonstrate a premature aging phenotype and develop certain age-related diseases earlier in their lifespan than what is seen in the general population. Age-related comorbidities may include the development of bone disease, metabolic disorders, neurologic impairment and immunosenescence. Age also appears to have an effect on traditional markers of HIV-1 disease progression, including CD4+T-cell count and viral load. These effects are not only a consequence of HIV-1 infection, but in many cases, are also linked to antiretroviral therapy. This review summarizes the complex interplay between HIV-1 infection and aging, and the impact that aging has on markers of HIV-1 disease.
authors.affiliation: Department of Microbiology & Immunology, Drexel University College of Medicine, 245 N 15th Street, New College Building, Philadelphia, PA 19102, USA ; Drexel University College of Medicine, 245 N 15th Street, New College Building, Philadelphia, PA 19102, USA.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Pirrone
authors.forename: David J
authors.initials: DJ
authors.lastname: Libon
authors.forename: Christian
authors.initials: C
authors.lastname: Sell
authors.forename: Chad A
authors.initials: CA
authors.lastname: Lerner
authors.forename: Michael R
authors.initials: MR
authors.lastname: Nonnemacher
authors.forename: Brian
authors.initials: B
authors.lastname: Wigdahl
keywords: HIV-1; aging; comorbidities; disease progression; neurocognitive impairment