title: Applications of nanosystems to anticancer drug therapy (Part II. Dendrimers, micelles, lipid-based nanosystems).
abstract: The great efforts of many researchers have brought down some of the barriers that exist to turn a good in vitro compound into a potential in vivo drug. The advent of pharmaceutical nanotechnology has allowed an arsenal of drugs with poor stability, low solubility, high off-target toxicity and other disadvantageous features, to be accessible as pharmaceutical products that could be administered to a patient. Nanotechnology was introduced in drug delivery very long ago, but has flourished with unprecedented intensity during the last twenty years and now a diversity of nano-based preparations are at clinical stage of development or already available in the market. Undoubtedly, nanotechnology plays a key role in future pharmaceutical development and pharmacotherapy. In the first part of this review, we have already discussed recent (2008-2012) patents on linear polymer-based nanosystems (nanogels, nanospheres and nanocapsules) applications to cancer therapy. Here, we have expanded such analysis to branched polymers (dendrimers), self-assembling nanomicelles and lipid-based nanocarriers.
authors.forename: María E
authors.initials: ME
authors.lastname: Ruiz
authors.forename: Melisa E
authors.initials: ME
authors.lastname: Gantner
authors.affiliation: Biopharmacy, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata (UNLP) - Argentinean National Council for Scientific and Technical Research (CONICET) CCT La Plata. 47 and 115, La Plata (B1900AJI), Buenos Aires, Argentina. alantalevi@gmail.com.
authors.forename: Alan
authors.initials: A
authors.lastname: Talevi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D050091:Dendrimers / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D036103:Nanotechnology / Q000379:methods / Q000639:trends*; D009369:Neoplasms / Q000737:chemistry / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; D004337:Drug Carriers; D008081:Liposomes; D008823:Micelles