title: Exploitation of eukaryotic subcellular targeting mechanisms by bacterial effectors.
abstract: Several bacterial species have evolved specialized secretion systems to deliver bacterial effector proteins into eukaryotic cells. These effectors have the capacity to modulate host cell pathways in order to promote bacterial survival and replication. The spatial and temporal context in which the effectors exert their biochemical activities is crucial for their function. To fully understand effector function in the context of infection, we need to understand the mechanisms that lead to the precise subcellular localization of effectors following their delivery into host cells. Recent studies have shown that bacterial effectors exploit host cell machinery to accurately target their biochemical activities within the host cell.
authors.affiliation: Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
authors.forename: Stuart W
authors.initials: SW
authors.lastname: Hicks
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Galán
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D058947:Bacterial Secretion Systems / Q000502:physiology*; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000502:physiology; D054878:Lipoylation / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism*; D054876:Prenylation / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D005229:Fatty Acids, Monounsaturated; D008565:Membrane Proteins; C054211:9-tetradecenoic acid