title: The effect of accompanying dominant follicle development/ovulation on the outcomes of frozen-thawed blastocyst transfer in HRT cycle.
abstract: The artificial regime was widespread used in frozen-thawed embryo transfer (FET). Some researchers asserted that if dominant follicles developed or ovulation occurred in hormone replacement FET cycles, this cycle should be cancelled because the fitting timing of transfer was hard to determine. In this study, we compared the difference between the outcome of frozen-thawed blastula transfer in hormone replacement treatment cycle (HRT) with or without dominant follicle development/ovulation. A total of 171 cases of frozen-thawed blastula transferred successfully in HRT cycle were retrospectively analyzed. Patients were divided into three groups according to dominant follicle development, ovulation or not: Group A, cycles without dominant follicle developing. Group B, cycles with dominant follicle developing but without ovulation. Group C, ovulated cycles. The results showed that there was no significant difference in the pregnancy rates or other parameters among the three groups, but the abortion rate was higher in group C than those of other two groups. To conclude, dominant follicle development/ovulation was not the necessary indication to cancel transfer cycles in HRT cycles, and our cautious decision would save many valuable cycles.
authors.affiliation: Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Techonlogy, Wuhan, The People's Republic of China.
authors.forename: Xuezhou
authors.initials: X
authors.lastname: Yang
authors.forename: Xiyuan
authors.initials: X
authors.lastname: Dong
authors.forename: Kai
authors.initials: K
authors.lastname: Huang
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.forename: Ting
authors.initials: T
authors.lastname: Xiong
authors.forename: Licheng
authors.initials: L
authors.lastname: Ji
authors.forename: Hanwang
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000328:Adult; D015331:Cohort Studies; D015925:Cryopreservation / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004624:Embryo Transfer / Q000379:methods*; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism / Q000628:therapy; D007986:Luteinizing Hormone / Q000378:metabolism; D008597:Menstrual Cycle / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology*; D010060:Ovulation / Q000502:physiology*; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D004967:Estrogens; D011374:Progesterone; D007986:Luteinizing Hormone
keywords: HRT; dominant follicles; frozen-thawed blastocyst transferred; ovulation; pregnancy rates