title: Standard additions-dilution method for absolute quantification in voltammetry of microparticles. Application for determining psychoactive 1,4-benzodiazepine and antidepressants drugs as adulterants in phytotherapeutic formulations.
abstract: A standard additions-dilution solid-state electrochemical method for the determination of psychoactive 1,4-benzodiazepine and antidepressants drugs used as adulterants in commercial slimming herbal formulations is described and compared with conventional standard addition method. The proposed method, based on the voltammetry of microparticles approach, permits quantify, via standard additions methodology, 1,4-benzodiazepine and antidepressants drugs in phytotherapeutic formulations with no need of sample dissolution using dilution with a reference electroactive compound. The method was used to measure 1,4-benzobenzodiazepines (clonazepam, flurazepam, alprazolam, midazolam, bromazepam, chlordiazepoxide, lorazepam and diazepam) and antidepressants (bupropion, sertraline, paroxetine and fluoxetine) in slimming formulations that have been commercialized in Brazil.
authors.affiliation: Departament de Química Analítica, Universitat de València, Dr. Moliner, 50, 46100 Burjassot, València, Spain. antonio.domenech@uv.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Doménech-Carbó
authors.forename: Mariele
authors.initials: M
authors.lastname: Martini
authors.forename: Leandro Machado
authors.initials: LM
authors.lastname: de Carvalho
authors.forename: Carine
authors.initials: C
authors.lastname: Viana
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Doménech-Carbó
authors.forename: Miguel
authors.initials: M
authors.lastname: Silva
mesh_terms: D000928:Antidepressive Agents / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D001569:Benzodiazepines / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D001938:Brazil; D004340:Drug Contamination; D055664:Electrochemical Techniques / Q000379:methods*; D028321:Plant Preparations / Q000032:analysis* / Q000737:chemistry
chemical_list: D000928:Antidepressive Agents; D028321:Plant Preparations; D001569:Benzodiazepines