title: Complex inheritance for susceptibility to sudden cardiac death.
abstract: Sudden cardiac death (SCD) from ventricular fibrillation during myocardial infarction is a leading cause of total and cardiovascular mortality. It has a multifactorial, complex nature and aggregates in families, implicating the involvement of heritable factors in the determination of risk. During the last few years, genome-wide association studies have uncovered common genetic variants modulating risk of SCD. We here review the current insight on genetic determinants of SCD in the community and describe the genome-wide association approaches undertaken thus far in uncovering genetic determinants of SCD risk.
authors.affiliation: Department of Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam (AMC), PO Box 22660, 1100 DD Amsterdam, The Netherlands. r.pazoki@amc.uva.nl.
authors.forename: Raha
authors.initials: R
authors.lastname: Pazoki
authors.forename: Michael W T
authors.initials: MW
authors.lastname: Tanck
authors.forename: Arthur A M
authors.initials: AA
authors.lastname: Wilde
authors.forename: Connie R
authors.initials: CR
authors.lastname: Bezzina
mesh_terms: D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D016757:Death, Sudden, Cardiac; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology; D010641:Phenotype