title: Efficacy of liver assisting in patients with hepatic encephalopathy with special focus on plasma exchange.
abstract: Severe liver injury result in development of hepatic encephalopathy (HE) and often also in brain edema that is a potentially fatal complication. HE and brain edema are correlated to the level and persistence of hyperammonemia and the presence of systemic inflammation. Treatment of HE and brain edema is based on restoring and keeping normal physiological variables including tonicity, blood gasses, lactate, temperature and vascular resistance by a wide variety of interventions. In addition liver support devices improve the stage of HE, cerebral metabolic rate for oxygen and glucose, and are used either as a bridge to liver transplantation or liver recovery in patients with fulminant hepatic failure and in patients with acute-on-chronic liver failure. This short review will mainly focus on the management and efficacy of doing plasma exchange on HE in patients with acute HE.
authors.affiliation: Department of Hepatology, A-2121, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.
authors.forename: Poul
authors.initials: P
authors.lastname: Stenbøg
authors.forename: Troels
authors.initials: T
authors.lastname: Busk
authors.forename: Fin Stolze
authors.initials: FS
authors.lastname: Larsen
mesh_terms: D000641:Ammonia / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000628:therapy*; D006501:Hepatic Encephalopathy / Q000628:therapy*; D006801:Humans; D017093:Liver Failure / Q000188:drug therapy; D008111:Liver Function Tests; D010951:Plasma Exchange / Q000009:adverse effects / Q000379:methods*; D010956:Plasmapheresis; D013534:Survival
chemical_list: D000641:Ammonia