title: Hyperthermia impaired human visual short-term memory: an fMRI study.
abstract: OBJECTIVE
  In order to investigate the effects of hyperthermia conditions on human cognitive performance, functional magnetic resonance imaging (fMRI) was employed to investigate human brain activation during visual short-term memory (VSTM) tasks under modulated hyperthermia conditions.
  
  
  METHODS
  A total of 38 right-handed healthy young male participants were randomly divided into control and hyperthermia groups who underwent VSTM tasks by using block design.
  
  
  RESULTS
  Compared with that of the control group, the reaction time of the hyperthermia group was longer in VSTM tasks (p = 0.019), but there was no significant difference between the two groups for the accuracy rate (p > 0.85). The fMRI data showed that the processing advantage of the right hemisphere was notably enhanced and that activity strength of the bilateral dorsolateral prefrontal cortex and right intra-parietal sulcus were significantly enhanced in the hyperthermia group.
  
  
  CONCLUSIONS
  These data provided neuroimaging evidence of the effect of hyperthermia conditions on the brain regions and also proved heat load decreases cognitive performance.
authors.affiliation: Department of Medical Imaging, Jinan Military General Hospital, Jinan, China.
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Jiang
authors.forename: Xiao
authors.initials: X
authors.lastname: Yang
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Shaowen
authors.initials: S
authors.lastname: Qian
authors.forename: Lun
authors.initials: L
authors.lastname: Zhao
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhou
authors.forename: Gang
authors.initials: G
authors.lastname: Sun
mesh_terms: D000328:Adult; D005334:Fever / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D008570:Memory, Short-Term; D011930:Reaction Time; D055815:Young Adult