title: Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats.
abstract: OBJECTIVE
  To evaluate the antiarthritic activity of Ajuga bracteosa using albino rats.
  
  
  METHODS
  The antiarthritic activity of 70% ethanolic extract of Ajuga bracteosa (EEAB) was evaluated against turpentine oil- and formaldehyde- induced acute non immunological and complete freund's adjuvant (CFA)-induced chronic immunological arthritis in albino rats.
  
  
  RESULTS
  EEAB showed a significant (P<0.05) and dose dependent inhibitory effect against acute and chronic models of arthritis. EEAB exhibited better antiarthritic activity than the standard aspirin.
  
  
  CONCLUSIONS
  EEAB exhibits a significant and promising antiarthritic activity against acute and chronic arthritis and supports the traditional use of Ajuga bracteosa for rheumatism and other inflammatory diseases.
authors.affiliation: Department of Pharmaceutical Sciences, Assam University, Silchar-788 011, Assam, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kaithwas
authors.forename: Raju
authors.initials: R
authors.lastname: Gautam
authors.forename: Sanjay M
authors.initials: SM
authors.lastname: Jachak
authors.forename: Arvind
authors.initials: A
authors.lastname: Saklani
mesh_terms: D031328:Ajuga / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001168:Arthritis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D001175:Arthrography; D002908:Chronic Disease; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D007596:Joints / Q000187:drug effects / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts
keywords: Adjuvant; Ajuga bracteosa; Cyclooxygenase; Formaldehyde; Turpentine