title: Anti-inflammatory and analgesic activities of Melanthera scandens.
abstract: OBJECTIVE
  To evaluate the anti-inflammatory and analgesic activities of leaf extract of Melanthera scandens (M. scandens).
  
  
  METHODS
  The crude leaf extract (39-111 mg/kg) of M. scandens was investigated for anti-inflammatory and analgesic activities using various experimental models. The anti-inflammatory activity was investigated using carragenin, egg-albumin induced oedema models, while acetic acid, formalin-induced paw licking and thermal-induced pain models were used to evaluate the antinociceptive property.
  
  
  RESULTS
  The extract caused a significant (P<0.05 - 0.001) dose-dependent reduction of inflammation and pains induced by different agents used.
  
  
  CONCLUSIONS
  The leaf extract possesses anti-inflammatory and analgesic effects which may be mediated through the phytochemical constituents of the plant.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
authors.forename: Jude E
authors.initials: JE
authors.lastname: Okokon
authors.forename: Anwanga E
authors.initials: AE
authors.lastname: Udoh
authors.forename: Samuel G
authors.initials: SG
authors.lastname: Frank
authors.forename: Louis U
authors.initials: LU
authors.lastname: Amazu
mesh_terms: D019342:Acetic Acid / Q000633:toxicity; D000418:Albumins / Q000009:adverse effects; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D019659:Asteraceae / Q000378:metabolism*; D002351:Carrageenan / Q000633:toxicity; D004487:Edema / Q000188:drug therapy; D005557:Formaldehyde / Q000633:toxicity; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D064209:Phytochemicals / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000378:metabolism
chemical_list: D000418:Albumins; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D064209:Phytochemicals; D010936:Plant Extracts; D005557:Formaldehyde; D002351:Carrageenan; D019342:Acetic Acid
keywords: Analgesic; Anti-inflammatory; Melanthera scandens