title: Effects of ketamine and LY341495 on the depressive-like behavior of repeated corticosterone-injected rats.
abstract: In the present study, to further validate repeated corticosterone (CORT)-treated rats as a treatment-resistant depression (TRD) model, we first examined the effect of ketamine, which is known to be effective for the treatment of TRD, on the depressive-like behavior of CORT-treated rats. In this model, ketamine significantly reduced the increased immobility time of CORT-treated rats during the forced swim test (FST), indicating that its efficacy against TRD could be detected using this model. We next examined the effect of LY341495, a group ΙΙ metabotropic glutamate (mGlu2/3) receptor antagonist, in this model to evaluate its potential for the alleviation of TRD. LY341495, similar to ketamine, attenuated the increased immobility time of CORT-treated rats during the FST. Therefore, these results suggest that mGlu2/3 receptor antagonists might be effective for patients with depression, including TRD.
authors.affiliation: Discovery Pharmacology Ι, Molecular Function and Pharmacology Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koike
authors.forename: Michihiko
authors.initials: M
authors.lastname: Iijima
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Chaki
mesh_terms: D000596:Amino Acids / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D003345:Corticosterone / Q000008:administration & dosage / Q000009:adverse effects*; D061218:Depressive Disorder, Treatment-Resistant / Q000188:drug therapy*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D046353:Immobility Response, Tonic / Q000187:drug effects; D007279:Injections, Subcutaneous; D007649:Ketamine / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors; D014966:Xanthenes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000596:Amino Acids; C114624:LY 341495; D018094:Receptors, Metabotropic Glutamate; D014966:Xanthenes; D007649:Ketamine; D003345:Corticosterone