title: Deposition of PLA/CDHA composite coating via electrospraying.
abstract: Composite coatings composed of carbonated calcium deficient hydroxyapatite (CDHA) and polylactic acid (PLA) were deposited on a PLA substrate surface via electrospraying. The operation parameters, structural properties, bioactivity, cell adhesion, and growth capability of as-fabricated PLA/CDHA coatings were investigated. The composite coating showed good biocompatibility and bioactivity. The deposited coating was also applied as a carrier to assist alendronate sodium (AS) local release. AS, an approved bisphosphonate drug used for the treatment of osteoporosis, was incorporated into a composite coating matrix via coelectrospraying. Its release behavior showed a long-term sustained release. This approach can be a potential coating technique for the surface modification of biopolymer implants.
authors.affiliation: Department of Bioengineering, The University of Toledo, Toledo, OH 43606, USA. Huan.Zhou@Rockets.utoledo.edu
authors.forename: Huan
authors.initials: H
authors.lastname: Zhou
authors.forename: Sarit B
authors.initials: SB
authors.lastname: Bhaduri
mesh_terms: D019386:Alendronate / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002118:Calcium / Q000737:chemistry*; D002448:Cell Adhesion / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D017886:Durapatite / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D017886:Durapatite; D002118:Calcium; D019386:Alendronate