title: Oxidation of anticancer Pt(II) complexes with monodentate phosphane ligands: towards stable but active Pt(IV) prodrugs.
abstract: The synthesis, characterization and cytotoxicity studies of two novel platinum(IV) complexes, trans-PtCl4(dma)(PPh3), 1, and trans-PtCl4(ipa)(PPh3), 2, where dma is dimethylamine and ipa is isopropylamine, have been carried out. Both complexes contain aliphatic amines trans to phosphane ligands as a good alternative to take advantage of the phosphane group lipophilicity and the stability of platinum(IV) to obtain more effective drugs. Moreover, the complexes are stable in solution and such stability allowed their antitumoral action and DNA interaction to be checked and proved.
authors.affiliation: Química Inorgánica, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
authors.forename: María Ángeles
authors.initials: MÁ
authors.lastname: Medrano
authors.forename: Amparo
authors.initials: A
authors.lastname: Álvarez-Valdés
authors.forename: Josefina
authors.initials: J
authors.lastname: Perles
authors.forename: Julio
authors.initials: J
authors.lastname: Lloret-Fillol
authors.forename: Sandra
authors.initials: S
authors.lastname: Muñoz-Galván
authors.forename: Amancio
authors.initials: A
authors.lastname: Carnero
authors.forename: Carmen
authors.initials: C
authors.lastname: Navarro-Ranninger
authors.forename: Adoración G
authors.initials: AG
authors.lastname: Quiroga
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D005978:Glutathione / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology; D010084:Oxidation-Reduction; D010720:Phosphines / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D009944:Organoplatinum Compounds; D010720:Phosphines; D011355:Prodrugs; D004247:DNA; D005978:Glutathione