title: Lipid-based formulations for oral administration of poorly water-soluble drugs.
abstract: Lipid-based drug delivery systems have shown great potentials in oral delivery of poorly water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed products. Pre-dissolving drugs in lipids, surfactants, or mixtures of lipids and surfactants omits the dissolving/dissolution step, which is a potential rate limiting factor for oral absorption of poorly water-soluble drugs. Lipids not only vary in structures and physiochemical properties, but also in their digestibility and absorption pathway; therefore selection of lipid excipients and dosage form has a pronounced effect on the biopharmaceutical aspects of drug absorption and distribution both in vitro and in vivo. The aim of this review is to provide an overview of the different lipid-based dosage forms from a biopharmaceutical point of view and to describe effects of lipid dosage forms and lipid excipients on drug solubility, absorption and distribution.
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. huiling.mu@sund.ku.dk
authors.forename: Huiling
authors.initials: H
authors.lastname: Mu
authors.forename: René
authors.initials: R
authors.lastname: Holm
authors.forename: Anette
authors.initials: A
authors.lastname: Müllertz
mesh_terms: D000284:Administration, Oral; D000818:Animals; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D005079:Excipients; D008055:Lipids; D004364:Pharmaceutical Preparations; D014867:Water
keywords: In vitro lipolysis; Lipid digestion; Lipid-based drug delivery systems; Lipids; Lymphatic transport; Poorly water-soluble drug