title: Effects of antimicrobial peptide revealed by simulations: translocation, pore formation, membrane corrugation and euler buckling.
abstract: We explore the effects of the peripheral and transmembrane antimicrobial peptides on the lipid bilayer membrane by using the coarse grained Dissipative Particle Dynamics simulations. We study peptide/lipid membrane complexes by considering peptides with various structure, hydrophobicity and peptide/lipid interaction strength. The role of lipid/water interaction is also discussed. We discuss a rich variety of membrane morphological changes induced by peptides, such as pore formation, membrane corrugation and Euler buckling.
authors.affiliation: Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education,College of Chemistry, Beijing Normal University, Beijing 100875, China. lhgao@bnu.edu.cn.
authors.forename: Licui
authors.initials: L
authors.lastname: Chen
authors.forename: Nana
authors.initials: N
authors.lastname: Jia
authors.forename: Lianghui
authors.initials: L
authors.lastname: Gao
authors.forename: Weihai
authors.initials: W
authors.lastname: Fang
authors.forename: Leonardo
authors.initials: L
authors.lastname: Golubovic
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008956:Models, Chemical
chemical_list: D023181:Antimicrobial Cationic Peptides; D008051:Lipid Bilayers