title: Expression and prognostic significance of hsa-miR-142-3p in acute leukemias.
abstract: OBJECTIVE
  The microRNA 142 (miR-142) is expressed at high levels in mature hematopoietic cells and has a crucial role during T-lymphocyte development. Its role in leukemogenesis is unclear.
  
  
  METHODS
  Expression of miR-142 was analyzed in acute myeloid and lymphoblastic leukemia cells (de novo, cell lines). Data were compared to expression in CD34+ hematopoietic cells. Based on the miR-142 expression, clinical data such as overall survival was analyzed.
  
  
  RESULTS
  MiR-142 expression in all leukemia cell lines and 86 % of the de novo samples was higher than in CD34+ cells. This difference could be detected in both, myeloid and lymphoid neoplastic cells. In AML patients with intermediate cytogenetic risk a high miR-142 expression was associated with a better overall survival.
  
  
  CONCLUSIONS
  MiR-142 expression in acute lymphoblastic as well as myeloid leukemia cells is higher than in CD34+ cells. Additionally, miR-142 expression might have prognostic relevance in AML-patients with otherwise an intermediate cytogenetic risk.
authors.affiliation: Department of Hematology, University of Rostock, Rostock, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Dahlhaus
authors.forename: C
authors.initials: C
authors.lastname: Roolf
authors.forename: S
authors.initials: S
authors.lastname: Ruck
authors.forename: S
authors.initials: S
authors.lastname: Lange
authors.forename: M
authors.initials: M
authors.lastname: Freund
authors.forename: C
authors.initials: C
authors.lastname: Junghanss
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality; D008297:Male; D035683:MicroRNAs / Q000032:analysis* / Q000502:physiology; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000401:mortality; D011379:Prognosis
chemical_list: C555159:MIRN142 microRNA, human; D035683:MicroRNAs