title: Serum amyloid A level is increased in neuromyelitis optica and atypical multiple sclerosis with smaller T2 lesion volume in brain MRI.
abstract: Serum amyloid A (SAA) is known to promote the development of T helper 17 cells (Th17) and can be a critical mediator of disease pathogenesis. We analyzed SAA levels in 40 patients with multiple sclerosis (MS) and related disorders, and 10 with non-inflammatory neurological disease (NIND) as controls. We found that SAA levels were significantly increased in neuromyelitis optica (NMO) patients and relapsing and remitting MS (RRMS) patients showing atypical phenotype with spinal cord lesions and smaller T2 lesion volume in brain MRI, resembling NMO. Therefore, SAA levels can be associated with clinical phenotypes in MS and NMO.
authors.affiliation: Department of Neurology, Musashino Red Cross Hospital, Tokyo, Japan. yokote@musashino.jrc.or.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yokote
authors.forename: Yohsuke
authors.initials: Y
authors.lastname: Yagi
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Amino
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kamata
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Mizusawa
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D009471:Neuromyelitis Optica / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D013116:Spinal Cord / Q000473:pathology; D058504:Th17 Cells / Q000276:immunology / Q000473:pathology; D055815:Young Adult
chemical_list: D000685:Serum Amyloid A Protein