title: Management of death rattle at end of life.
abstract: Noisy breathing or death rattle is a common clinical sign in the final days of life. When it occurs, the level of consciousness is usually low and it is generally assumed that patients are not distressed by it. Despite the assumption that patients are not distressed, death rattle is usually actively treated in palliative care settings through a combination of pharmacological and non-pharmacological measures. Anti-cholinergic or anti-muscarinic medications are the drugs of choice in practice, even in the absence of patient distress, despite there being no conclusive evidence to suggest that any drug is superior to placebo. In addition, a recent Cochrane review suggested that there is a lack of supporting evidence for the use of anti-cholinergics to treat death rattle (Wee and Hillier, 2010). The choice of drug is based on the various properties of the drug and the desired effects. However, treatment is focused on alleviating the perceived distress of family members rather than aimed specifically at benefiting the patient. Moreover, anti-cholinergic drugs can result in unpleasant side-effects such as urinary retention and dry mouth for patients who are probably unable to report symptoms. Recent research calls for prescribers to consider carefully why they are treating death rattle. Moreover, families need to be reassured and have it explained to them that it is unlikely that the patient is distressed and why this is the case.
authors.affiliation: Wexford General Hospital, Wexford, Ireland.
authors.forename: Shelagh
authors.initials: S
authors.lastname: Twomey
authors.forename: Maura
authors.initials: M
authors.lastname: Dowling
mesh_terms: D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D003643:Death; D006801:Humans; D015994:Incidence; D009732:Nursing Care / Q000379:methods; D010166:Palliative Care / Q000379:methods*; D011187:Posture; D012135:Respiratory Sounds / Q000187:drug effects*; D013727:Terminal Care / Q000379:methods*
chemical_list: D018680:Cholinergic Antagonists