title: Organ targeted mini-invasive approach in the treatment of colorectal cancer liver metastases: role of intraoperative ultrasonography as guidance in liver resection.
abstract: Surgery is still considered the gold standard therapy for patient carries of colorectal liver metastases (CLM) because related to more chance of long-term survival. The major limitation of surgical approach is its technical feasibility because of the inability to completely clear the metastatic disease in a single operation while preserving enough future liver remnant. Thus, the two-stage hepatectomy is generally recommended for these patients. We have shown how with an extensive use of intraoperative ultrasonography based on strict criteria is possible performing curative resection in a single stage despite complex tumor presentation as in multifocal and bilateral spread. This strategy aims to keep the liver skeleton although allowing the radical tumor clearance: as consequence it is minimized the need for a multistep surgical strategy, and is enhanced the feasibility of repeated hepatectomies in the event of recurrent disease.
authors.affiliation: Liver Surgery Unit, Department of Surgery, University of Milan, Humanitas Cancer Center, Rozzano, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Procopio
authors.forename: G
authors.initials: G
authors.lastname: Torzilli
mesh_terms: D015179:Colorectal Neoplasms / Q000473:pathology*; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D007430:Intraoperative Care; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary / Q000601:surgery*; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional