title: [Clinical effectiveness of probiotics in complex treatment of infants with cow's milk allergy].
abstract: 6-8% of infants have food hypersensitivity or allergy that often manifest as atopic dermatitis. Formation of intestinal microbiocenosis is occurring during the same age range. There are some research data about the influence of probiotic on clinical course of atopic dermatitis. The aim of this study was to estimate the effect of Bifidobacterium lactis BB-12 (1 х 10(9 0 CFU) and Streptococcus thermophilus TH-4 (1 х 10(8) CFU) administration to infants with atopic dermatitis and cow's milk allergy. We conducted an open randomized prospective clinical study. 60 infants aged of 3-12 months with the diagnosis of atopic dermatitis and allergy to cow's milk protein were enrolled. Children were divided into 2 groups, one of that received probiotic during 4 weeks. Results were estimated with SCORAD scoring after 4 and 8 weeks of treatment. The difference in SCORAD scores between a visit 1 and a visit 3 in infants who in complex treatment received the probiotic strains was 44,05 (3,97) as compared with 38,94 (5,65) in the control group (р<0,05). As a result of our study it is possible to draw a conclusion that administration of probiotics to infants with atopic dermatitis and cow's milk allergy in addition to elimination diet and base treatment improves clinical symptoms of the disease.
authors.affiliation: Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
authors.forename: O
authors.initials: O
authors.lastname: Ivakhnenko
authors.forename: S
authors.initials: S
authors.lastname: Niankovskyy
mesh_terms: D000818:Animals; D001644:Bifidobacterium; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology; D004035:Diet Therapy / Q000379:methods; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007223:Infant; D008892:Milk / Q000009:adverse effects; D016269:Milk Hypersensitivity / Q000178:diet therapy / Q000188:drug therapy*; D019936:Probiotics / Q000627:therapeutic use*; D011446:Prospective Studies; D048249:Streptococcus thermophilus; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007073:Immunoglobulin E