title: 18F-FDG PET/CT findings preceded elevation of serum proteinase 3 antineutrophil cytoplasmic antibodies in Wegener granulomatosis.
abstract: A 67-year-old woman underwent F-FDG PET/CT after developing a fever of unknown origin. PET/CT revealed intensive FDG uptake at the nasal and lung lesions. On the laboratory data, serum myeloperoxidase antineutrophil cytoplasmic antibodies (ANCA) titer was elevated, although serum directed against proteinase 3 (PR3) ANCA titer was within normal limits. One month after treatment, follow-up PET/CT revealed decreased FDG uptake at the lesions. One year later, serum PR3-ANCA titer elevated, which finally led to a diagnosis of Wegener granulomatosis (WG). WG lesions may be detected earlier by FDG PET/CT than by serum PR3-ANCA titers.
authors.affiliation: From the *Department of Radiology, National Center of Neurology and Psychiatry, †Division of Nuclear Medicine, National Center for Global Health and Medicine, and ‡Division of Rheumatic Diseases, National Center for Global Health and Medicine, Tokyo, Japan.
authors.forename: Kimiteru
authors.initials: K
authors.lastname: Ito
authors.forename: Ryogo
authors.initials: R
authors.lastname: Minamimoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamashita
authors.forename: Miyako
authors.initials: M
authors.lastname: Morooka
authors.forename: Momoko
authors.initials: M
authors.lastname: Okasaki
authors.forename: Akio
authors.initials: A
authors.lastname: Mimori
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kubota
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood* / Q000276:immunology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D014890:Granulomatosis with Polyangiitis / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D064847:Multimodal Imaging; D053146:Myeloblastin / Q000276:immunology*; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D019788:Fluorodeoxyglucose F18; D053146:Myeloblastin