title: Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol-induced hepatotoxicity in rats.
abstract: OBJECTIVE
  To investigate the hepatoprotective activity of methanolic leaf extract of Cyathea gigantea (C. gigantea) against paracetamol induced liver damage in rats.
  
  
  METHODS
  The hepatoprotective activity for plant extract was investigated for paracetamol induced hepatoxicity in rats. Wistar albino rats of either sex were divided into five groups of 6 animals each and are given orally the following treatment for seven days. The normal control group was given 1% Na.CMC 1 mL/kg bw, p.o. Paracetamol at dose of 1 g/kg bw, p.o. was given as toxic dose for inducing hepatotoxicity. Silymarin (50 mg/kg, p.o.) was given as reference standard. Two doses of C. gigantea extract i.e., 100 mg/kg, p.o. and 200 mg/kg, p.o. were tested for hepatoprotective activity. The treatment was given for seven days and after 24 h of last treatment blood was collected from retro-orbital plexus and analysed for various serum parameters like serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP), total bilirubin (TB) and total protein (TP) in different groups.
  
  
  RESULTS
  The paracetamol intoxication lead to histological and biochemical deteriorations. The treatment with methanolic leaf extract of C. gigantea reduced the elevated levels of SGOT, SGPT, ALP, TB and also reversed the hepatic damage towards normal which further supports the hepatoprotective activity of leaf extract of C. gigantea.
  
  
  CONCLUSIONS
  The methanolic extract of leaves of C. gigantea at doses of 100 mg/kg bw and 200 mg/kg bw have significant effect on liver of paracetamol induced hepatotoxicity model in rats.
authors.affiliation: A.U College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P, India-530003.
authors.forename: P Madhu
authors.initials: PM
authors.lastname: Kiran
authors.forename: A Vijaya
authors.initials: AV
authors.lastname: Raju
authors.forename: B Ganga
authors.initials: BG
authors.lastname: Rao
mesh_terms: D000082:Acetaminophen / Q000633:toxicity; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D018712:Analgesics, Non-Narcotic / Q000633:toxicity; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases; D001663:Bilirubin; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018712:Analgesics, Non-Narcotic; D000975:Antioxidants; D010936:Plant Extracts; D000082:Acetaminophen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin
keywords: Cyathea gigantea; Hepatoprotective; Hepatotoxicity; Paracetamol; Silymarin