title: [Secondary prevention of stroke with effective antihypertensive treatment].
abstract: In this meta-analysis, four of five placebo-controlled studies showed that antihypertensive treatment prevented stroke recurrence, most markedly in a study with a combination of an angiotensin-converting enzyme inhibitor and a diuretic. Studies with beta-blockers were not included. Two head-to-head comparisons of a calcium antagonist and an angiotensin receptor antagonist showed no clear difference. Danish studies show that approximately 60% of patients with stroke are hypertensive one year after discharge from hospital. Antihypertensive treatment should be started or intensified in such patients.
authors.affiliation: Neurobiologisk Forskningsenhed, Neurocentret, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark.
authors.forename: Signe
authors.initials: S
authors.lastname: Boye Knudsen
authors.forename: Svend
authors.initials: S
authors.lastname: Strandgaard
authors.forename: Olaf B
authors.initials: OB
authors.lastname: Paulson
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D016017:Odds Ratio; D012307:Risk Factors; D055502:Secondary Prevention; D020521:Stroke / Q000000981:diagnostic imaging / Q000517:prevention & control*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004232:Diuretics