title: Structural organization of viral RNA-dependent RNA polymerases.
abstract: This review describes available data on the structure of viral RNA-dependent RNA polymerases (RdRP) obtained from X-ray analysis and discusses the functional significance of the structural elements of these enzymes. Because most of the studies done to date relate to RdRP structures of picorna-, flavi-, and caliciviruses, here we consider mostly the structures of RdRP of these groups of viruses, and also include information about polymerases of other virus families.
authors.affiliation: Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. barsa19@rambler.ru
authors.forename: G S
authors.initials: GS
authors.lastname: Shatskaya
authors.forename: T M
authors.initials: TM
authors.lastname: Dmitrieva
mesh_terms: D018360:Crystallography, X-Ray; D006801:Humans; D012324:RNA-Dependent RNA Polymerase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D014780:Viruses / Q000737:chemistry / Q000201:enzymology* / Q000235:genetics
chemical_list: D014764:Viral Proteins; D012324:RNA-Dependent RNA Polymerase