title: Stress-induced transcription of regulator of G protein signaling 2 (RGS2) by heat shock transcription factor HSF1.
abstract: Expression of the RGS2 gene modulates RGS2 activity toward G protein-coupled signaling in diverse cellular processes. In this study, RGS2 transcription was induced in HeLa and rat aorta smooth muscle cells by exposure to febrile temperatures or proteotoxic stress. The promoter region of RGS2 contained a binding sequence of HSF1, which is an activator of the heat shock protein gene, and was inducibly bound by stress-activated HSF1. A single nucleotide change identified in the RGS2 promoter of hypertensive patients abolished HSF1-regulated expression of RGS2, suggesting that activated HSF1 is involved in blood pressure regulation via modulation of RGS2 expression.
authors.affiliation: Division of Health Sciences, Kanazawa University Graduate School of Medical Science, 5-11-80 Kodatsuno, Kanazawa 920-0942, Ishikawa, Japan.
authors.forename: Azumi
authors.initials: A
authors.lastname: Ota
authors.forename: Maki
authors.initials: M
authors.lastname: Sawai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakurai
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D006367:HeLa Cells; D000076249:Heat Shock Transcription Factors; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D011401:Promoter Regions, Genetic; D020710:RGS Proteins / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D013312:Stress, Physiological / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; C000619706:HSF1 protein, human; D000076249:Heat Shock Transcription Factors; C000619709:Hsf1 protein, rat; D020710:RGS Proteins; C087182:RGS2 protein, human; C514563:RGS2 protein, rat; D014157:Transcription Factors