title: Tumour-surrounding adipocytes are active players in breast cancer progression.
abstract: Accumulating recent evidence highlights the tumour-surrounding adipose tissue as a key component of breast cancer progression. We have recently demonstrated that a bidirectional crosstalk is established with breast cancer cells and tumour-surrounding adipocytes. Tumour cell secretions are able to modify tumour-surrounding adipocytes to an activated state that we have named Cancer-Associated Adipocytes (CAAs). The role of CAAs in breast cancer progression, as well as the potential amplification of this negative effect in obesity conditions will be discussed.
authors.affiliation: UPS, IPBS, université de Toulouse, 31077 Toulouse cedex, France. catherine.muller@ipbs.fr
authors.forename: Catherine
authors.initials: C
authors.lastname: Muller
mesh_terms: D017667:Adipocytes / Q000473:pathology* / Q000502:physiology*; D000818:Animals; D001943:Breast Neoplasms / Q000209:etiology / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D009765:Obesity / Q000150:complications / Q000473:pathology; D059016:Tumor Microenvironment / Q000502:physiology*