title: Cytotoxicity of methanol extracts of Elaeis guineensis on MCF-7 and Vero cell lines.
abstract: OBJECTIVE
  To investigate the cytotoxic effect of Elaeis guineensis methanol extract on MCF-7 and Vero cell.
  
  
  METHODS
  In vitro cytotoxicity was evaluated in by MTT assay. Cell morphological changes were observed by using light microscope.
  
  
  RESULTS
  The MTT assay indicated that methanol extract of the plant exhibited significant cytotoxic effects on MCF-7. Morphological alteration of the cell lines after exposure with Elaeis guineensis extract were observed under phase contrast microscope in the dose dependent manner.
  
  
  CONCLUSIONS
  The results suggest the probable use of the Elaeis guineensis methanol extract in preparing recipes for cancer-related ailments. Further studies on isolation of metabolites and their in vivo cytotoxicity are under investigation.
authors.affiliation: Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia.
authors.forename: Soundararajan
authors.initials: S
authors.lastname: Vijayarathna
authors.forename: Sreenivasan
authors.initials: S
authors.lastname: Sasidharan
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D028023:Arecaceae / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D006801:Humans; D061986:MCF-7 Cells; D000432:Methanol; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D014709:Vero Cells
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D000432:Methanol
keywords: Cell morphology; Cytotoxicity; Elaeis guineensis; Growth inhibitory