title: Copper-mediated, palladium-catalyzed cross-coupling of 3-iodochromones, thiochromones, and quinolones with ethyl bromodifluoroacetate.
abstract: The palladium-catalyzed cross-coupling reaction of 3-iodochromones, thiochromones, and quinolones with ethyl bromodifluoroacetate in the presence of a copper mediator is reported. Under optimized conditions, all reactions worked well and provided difluoro-containing products in moderate to excellent yields.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, People's Republic of China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Han
authors.forename: Zhizhou
authors.initials: Z
authors.lastname: Yue
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: He
authors.forename: Chunhao
authors.initials: C
authors.lastname: Yang
mesh_terms: D002384:Catalysis; D002867:Chromones / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D005463:Fluoroacetates / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D015363:Quinolones / Q000737:chemistry*
chemical_list: D002867:Chromones; D005463:Fluoroacetates; D015363:Quinolones; D010165:Palladium; D003300:Copper