title: Effect of kramecyne on the inflammatory response in lipopolysaccharide-stimulated peritoneal macrophages.
abstract: Kramecyne is a new peroxide, it was isolated from Krameria cytisoides, methanol extract, and this plant was mostly found in North and South America. This compound showed potent anti-inflammatory activity; however, the mechanisms by which this compound exerts its anti-inflammatory effect are not well understood. In this study, we examined the effects of kramecyne on inflammatory responses in mouse lipopolysaccharide- (LPS-) induced peritoneal macrophages. Our findings indicate that kramecyne inhibits LPS-induced production of tumor necrosis factor (TNF- α ) and interleukin- (IL-) 6. During the inflammatory process, levels of cyclooxygenase- (COX-) 2, nitric oxide synthase (iNOS), and nitric oxide (NO) increased in mouse peritoneal macrophages; however, kramecyne suppressed them significantly. These results provide novel insights into the anti-inflammatory actions and support its potential use in the treatment of inflammatory diseases.
authors.affiliation: Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, Coyoacán, 04960 México, DF, Mexico.
authors.forename: E
authors.initials: E
authors.lastname: Sánchez-Miranda
authors.forename: J
authors.initials: J
authors.lastname: Lemus-Bautista
authors.forename: S
authors.initials: S
authors.lastname: Pérez
authors.forename: J
authors.initials: J
authors.lastname: Pérez-Ramos