title: Breed predispositions in canine mast cell tumour: a single centre experience in the United Kingdom.
abstract: Genetic factors play a major role in carcinogenesis. Many breeds have been reported to be predisposed to mast cell tumour (MCT) development using various methods and diverse control populations. A database of 222 dogs with MCT seen at a UK university referral hospital was compared to three control populations, namely, an insured population of UK dogs, registrations with the UK Kennel Club and other dogs seen through the same hospital. Odds ratios were calculated for each breed. Boxers, Labradors, Golden Retrievers and Staffordshire Bull Terriers appeared predisposed to MCT development. English Springer Spaniels, English Cocker Spaniels, German Shepherd Dogs, West Highland White Terriers and Cavalier King Charles Spaniels were underrepresented.
authors.affiliation: Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom. Jhw36@cam.ac.uk
authors.forename: James
authors.initials: J
authors.lastname: Warland
authors.forename: Jane
authors.initials: J
authors.lastname: Dobson
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000453:epidemiology / Q000235:genetics*; D004285:Dogs; D020022:Genetic Predisposition to Disease; D034801:Mastocytoma / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D016017:Odds Ratio; D006113:United Kingdom / Q000453:epidemiology
keywords: Breed; Dog; Incidence; Mast cell tumour