title: Toward global tractography.
abstract: Diffusion-based tractography is an ill-posed problem, because the step-by-step reconstruction of a fibre bundle trajectory cannot afford any serious mistake in the evaluation of the local fibre orientations. Such evaluation is difficult, however, because the myriad fibres passing through a single voxel follow different directions. Modelling tractography as a global inverse problem is a simple framework which addresses the ill-posed nature of the problem. The key idea is that the results of tractography in the neighbourhood of an ambiguous local diffusion profile can help to infer the local fibre directions. This paper provides an overview of past achievements of global tractography and proposes guidelines for a future research programme in the hope that the potential of the technique will increase the interest of the community.
authors.affiliation: Neurospin, I2BM, CEA, Saclay, France. jfmangin@gmail.com
authors.forename: J-F
authors.initials: JF
authors.lastname: Mangin
authors.forename: P
authors.initials: P
authors.lastname: Fillard
authors.forename: Y
authors.initials: Y
authors.lastname: Cointepas
authors.forename: D
authors.initials: D
authors.lastname: Le Bihan
authors.forename: V
authors.initials: V
authors.lastname: Frouin
authors.forename: C
authors.initials: C
authors.lastname: Poupon
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D063132:Connectome / Q000379:methods*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008953:Models, Anatomic; D008959:Models, Neurological; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D009415:Nerve Net / Q000033:anatomy & histology*
keywords: Connectome; Diffusion MRI; Global tractography