title: Yellow pigments, fomitellanols A and B, and drimane sesquiterpenoids, cryptoporic acids P and Q, from Fomitella fraxinea and their inhibitory activity against COX and 5-LO.
abstract: Yellow pigments, fomitellanols A (1a) and B (2a), and drimane-type sesquiterpenoid ethers of isocitric acid, cryptoporic acids P (3) and Q (4), have been isolated from the fruiting bodies of Fomitella fraxinea (Polyporaceae). Their structures were established by a combination of extensive NMR spectroscopy and/or X-ray crystallographic analyses, and their biological activity against COX-1, COX-2, and 5-LO was investigated.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan. yosikawa@ph.bunri-u.ac.jp
authors.forename: Kazuko
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Koso
authors.forename: Masumi
authors.initials: M
authors.lastname: Shimomura
authors.forename: Masami
authors.initials: M
authors.lastname: Tanaka
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imagawa
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Arihara
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hashimoto
mesh_terms: D018360:Crystallography, X-Ray; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D000081223:Polycyclic Sesquiterpenes; D011124:Polyporaceae / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane; C583762:fomitellanol A; C583765:fomitellanol B