title: Histopathological studies of acute and chronic effects of Calliandra portoricensis leaf extract on the stomach and pancreas of adult Swiss albino mice.
abstract: OBJECTIVE
  To evaluate the consequence of oral administration of Calliandra portoricensis (C. portoricensis) leaf extract on the stomach and pancreas in Swiss albino mice.
  
  
  METHODS
  Three groups of mice (B, C and D) were treated with 4 mg/kg of C. portoricensis extract. Group A was the control and received an equivalent volume of distilled water. Group B received C. portoricensis leaf extract for 7 days, Group C received C. portoricensis leaf extract for 14 days, and Group D received C. portoricensis leaf extract for 28 days. At different stages in the study, the mice were sacrificed and the stomach and pancreas were excised and fixed in 10% formol saline for histological analysis.
  
  
  RESULTS
  The result showed a normal microstructural outline in groups B and C as compared with the control. However, animals in group D showed disorganization of the mucosa and discontinuation of epithelial lining of the stomach while the islets of Langerans in the pancreas were at various degree of degeneration as compared with the control mice.
  
  
  CONCLUSIONS
  The present finding suggests that chronic administration (28 days as seen in this study) of C. portoricensis leaf extract may inhibit the proper function of the stomach and pancreas.
authors.affiliation: Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
authors.forename: David A
authors.initials: DA
authors.lastname: Ofusori
authors.forename: Adebomi O
authors.initials: AO
authors.lastname: Adejuwon
mesh_terms: D000818:Animals; D007887:Fabaceae / Q000737:chemistry*; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D013270:Stomach / Q000187:drug effects* / Q000473:pathology
chemical_list: D010936:Plant Extracts
keywords: Calliandra portoricensis; Degeneration; Disorganization; Histology; Langerans; Pancreas; Stomach