title: Pharmacological strategies to resolve acute inflammation.
abstract: The inflammatory response is a physiological process that has the major role of restoring tissue homeostasis. However, uncontrolled or unresolved inflammation may cause tissue damage and contribute to the pathogenesis of chronic inflammatory and autoimmune diseases. Current pharmacological therapies to treat inflammatory maladies focus on inhibition of the productive phase of the inflammatory response including inhibition of leukocyte influx. Resolution of inflammation is an active process, which relies on the production of pro-resolving molecules and activation of intracellular pathways. Here, we will discuss mechanisms and therapeutic potential of pharmacological strategies, which accelerate resolution in animal models of acute inflammation by mimicking or inducing natural pathways of resolution phase of inflammation.
authors.affiliation: Imunofarmacologia, Departamento de Bioquímica e Imunologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Lirlândia Pires
authors.initials: LP
authors.lastname: Sousa
authors.forename: Ana Leticia
authors.initials: AL
authors.lastname: Alessandri
authors.forename: Vanessa
authors.initials: V
authors.lastname: Pinho
authors.forename: Mauro Martins
authors.initials: MM
authors.lastname: Teixeira
mesh_terms: D000818:Animals; D017305:Annexin A1 / Q000276:immunology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000242:Cyclic AMP / Q000276:immunology; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000276:immunology
chemical_list: D017305:Annexin A1; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D010726:Phosphodiesterase Inhibitors; D017382:Reactive Oxygen Species; C573274:annexin A1, mouse; D000242:Cyclic AMP