title: Human erythrocytes covered with magnetic core-shell nanoparticles for multimodal imaging.
abstract: Surface functionalization of human red blood cells (hRBCs) with fluorescent and magnetic silica core-shell nanoparticles is used to design a carrier suitable for multimodal imaging with a long circulating time. The coated magnetic hRBCs show no hemolytic activity, while the advantage of the affinity of proteins for silica allows a further coating.
authors.affiliation: Université Pierre et Marie Curie UPMC-CNRS, Laboratoire Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques PECSA UMR 7195, 4 place Jussieu, 75252 Paris, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Laurencin
authors.forename: Nithavong
authors.initials: N
authors.lastname: Cam
authors.forename: Thomas
authors.initials: T
authors.lastname: Georgelin
authors.forename: Olivier
authors.initials: O
authors.lastname: Clément
authors.forename: Gwennhael
authors.initials: G
authors.lastname: Autret
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Siaugue
authors.forename: Christine
authors.initials: C
authors.lastname: Ménager
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry*; D004912:Erythrocytes / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D018613:Microscopy, Confocal; D011859:Radiography; D012822:Silicon Dioxide / Q000737:chemistry; D013154:Spleen / Q000000981:diagnostic imaging
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D012822:Silicon Dioxide; D016650:Fluorescein-5-isothiocyanate
keywords: core-shell magnetic nanoparticles; human red blood cells; multimodal imaging; surface decoration