title: Comparative study of microbial-derived phenolic metabolites in human feces after intake of gin, red wine, and dealcoholized red wine.
abstract: The analysis of microbial phenolic metabolites in fecal samples from in vivo studies is crucial to understanding the potential modulatory effects derived from polyphenol consumption and its overall health effects, particularly at the gut level. In this study, the composition of microbial phenolic metabolites in human feces collected after regular consumption of either red wine, dealcoholized red wine, or gin was analyzed by UPLC-ESI-MS/MS. Red wine interventions produce a change in the content of eight phenolic acids, which are probably derived from the catabolism of flavan-3-ols and anthocyanins, the main flavonoids in red wine. Moreover, alcohol seemed not to influence the formation of phenolic metabolites by the gut microbiota. A principal component analysis revealed large interindividual differences in the formation of microbial metabolites after each red wine polyphenol intervention, but not after the gin intervention, indicating differences in the gut microbial composition among subjects.
authors.affiliation: Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM , c/Nicolás Cabrera 9, 28049 Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Jiménez-Girón
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Queipo-Ortuño
authors.forename: Maria
authors.initials: M
authors.lastname: Boto-Ordóñez
authors.forename: Irene
authors.initials: I
authors.lastname: Muñoz-González
authors.forename: Fernando
authors.initials: F
authors.lastname: Sánchez-Patán
authors.forename: Maria
authors.initials: M
authors.lastname: Monagas
authors.forename: Pedro J
authors.initials: PJ
authors.lastname: Martín-Álvarez
authors.forename: Mora
authors.initials: M
authors.lastname: Murri
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Tinahones
authors.forename: Cristina
authors.initials: C
authors.lastname: Andrés-Lacueva
authors.forename: Begoña
authors.initials: B
authors.lastname: Bartolomé
authors.forename: M Victoria
authors.initials: MV
authors.lastname: Moreno-Arribas
mesh_terms: D000434:Alcoholic Beverages / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D000431:Ethanol / Q000494:pharmacology*; D005243:Feces / Q000737:chemistry* / Q000382:microbiology*; D005419:Flavonoids / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D059808:Polyphenols / Q000032:analysis / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry; D014920:Wine / Q000032:analysis*
chemical_list: D005419:Flavonoids; D059808:Polyphenols; D000431:Ethanol