title: Sensitivity and specificity of time-domain versus spectral-domain optical coherence tomography in diabetic macular edema.
abstract: OBJECTIVE
  The purpose was to evaluate the sensitivity and specificity of measurements of central macular thickness (CMT) in diabetic macular edema using stratus time-domain and cirrus spectral-domain optical coherence tomography (OCT; Carl Zeiss Meditec, Dublin, CA).
  
  
  METHODS
  A total of 36 eyes from 19 patients with clinically significant diabetic macular edema (DME) were included. All participants underwent automated scanning patterns using cirrus HD-OCT and stratus OCT examinations on the same day. The sensitivity/specificity of retinal thickness measurements was calculated from published normative data. Agreement was calculated using Bland--Altman method. The receiver operating characteristic curves (ROC) and areas under the ROC were plotted.
  
  
  RESULTS
  The mean difference between the cirrus HD-OCT and stratus OCT in the central foveal zone was 49.89 μm. Bland--Altman analysis confirmed that the retinal thickness measurements had poor agreement in patients with DME. The areas under the ROC for retinal thickness measurements were 0.88 using cirrus HD-OCT and 0.94 with stratus.
  
  
  CONCLUSIONS
  In patients with DME, the cirrus HD-OCT gives a higher reading than stratus OCT with poor agreement between the devices in most regions within the nine subfield zones. The sensitivity and specificity of the stratus OCT was comparable to the cirrus.
authors.affiliation: Department of Retinal and Laser Research, Kings College Hospital and School of Medicine, Denmark Hill, United Kingdom, London, United Kingdom.
authors.forename: Nishal
authors.initials: N
authors.lastname: Patel
authors.forename: Haziq
authors.initials: H
authors.lastname: Chowdhury
authors.forename: Richard
authors.initials: R
authors.lastname: Leung
authors.forename: Sobha
authors.initials: S
authors.lastname: Sivaprasad
mesh_terms: D000465:Algorithms; D003930:Diabetic Retinopathy / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*