title: High- versus low-volume polyethylene glycol plus laxative versus sennosides for colonoscopy preparation in children.
abstract: OBJECTIVE
  Many protocols of bowel preparation are available for use in children; however, none of them is commonly accepted. The aim of the study was to evaluate the efficacy and acceptability of high-volume polyethylene glycol (PEG) versus low-volume PEG combined with bisacodyl (BPEG) versus sennosides for colonoscopy preparation in children.
  
  
  METHODS
  Participants ages 10 to 18 years were randomly assigned to receive either PEG 60 or PEG 30 mL kg⁻¹ day⁻¹ plus oral bisacodyl 10 to 15 mg/day or sennosides 2 mg kg⁻¹ day⁻¹ for 2 days. A blinded assessment of bowel cleansing was made by the endoscopist according to the Aronchick and Ottawa scales. Patient acceptability was evaluated with the visual-analog scale. Analysis was done on an available case analysis basis.
  
  
  RESULTS
  Of 240 patients enrolled in the study 234 patients were available for analysis of the efficacy of colon cleansing. There were no significant differences found among the 3 groups for the proportions of participants with excellent/good (PEG: 35/79, BPEG: 26/79, sennosides 25/76) and poor/inadequate (PEG: 20/79, BPEG: 28/79, sennosides 28/76) bowel preparation evaluated with the Aronchick scale and for the mean Ottawa total score (PEG: 5.47 ± 3.63, BPEG: 6.22 ± 3.3, sennosides: 6.18 ± 3.53). Acceptability of bowel cleansing protocol was similar in all of the groups (P = 0.8).
  
  
  CONCLUSIONS
  All 3 cleansing methods showed similar efficacy and tolerability; however, none of them was satisfactory.
authors.affiliation: Department of Gastroenterology, Hepatology and Feeding Disorders, Children's Memorial Health Institute, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Kierkus
authors.forename: Andrea
authors.initials: A
authors.lastname: Horvath
authors.forename: Monika
authors.initials: M
authors.lastname: Szychta
authors.forename: Marek
authors.initials: M
authors.lastname: Woynarowski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wegner
authors.forename: Anna
authors.initials: A
authors.lastname: Wiernicka
authors.forename: Maciej
authors.initials: M
authors.lastname: Dadalski
authors.forename: Mikolaj
authors.initials: M
authors.lastname: Teisseyre
authors.forename: Piotr
authors.initials: P
authors.lastname: Dziechciarz
mesh_terms: D000293:Adolescent; D001726:Bisacodyl / Q000494:pharmacology; D002400:Cathartics / Q000494:pharmacology*; D002648:Child; D002985:Clinical Protocols; D003106:Colon / Q000187:drug effects*; D003113:Colonoscopy; D003672:Defecation / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D017060:Patient Satisfaction; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D012676:Senna Extract / Q000494:pharmacology*; D029846:Senna Plant / Q000737:chemistry*
chemical_list: D002400:Cathartics; D001726:Bisacodyl; D011092:Polyethylene Glycols; D012676:Senna Extract