title: [Clinical features and homological analysis of Pichia ohmeri-caused hospital-acquired fungemia in premature infants].
abstract: OBJECTIVE
  To analyze the clinical features of fungemia caused by Pichia ohmeri (P. ohmeri) in neonate intensive care unit and explore its molecular biological characteristics so as to improve its diagnosis and treatment level.
  
  
  METHODS
  The clinical data of 6 infected infants were retrospectively analyzed. The strains obtained from them were identified and homological analysis was performed through randomly amplified polymorphic assay to explore the epidemiological characteristics of this nosocomial infection.
  
  
  RESULTS
  Before the isolation of P. ohmeri, they received intravenous antibacterial therapy for 13 - 45 days. Among them, 4 received mechanical ventilation and 5 had a peripheral insertion of central venous catheters. Five infants were healed after a therapy of caspofungin for 15 - 30 days. One neonate recurred after a 30-day administration of fluconazole. The strain was identified and confirmed as P. ohmeri. RAPD genotyping results showed that all 6 strains were from the same clone. No similar cases occurred after positive control measures despite a negative epidemiological sampling.
  
  
  CONCLUSIONS
  P. ohmeri may cause premature infant fungemia and lead to its spread in hospital. Hospital infection control is a key point. And caspofungin is both safe and effective in the therapy of neonate fungemia.
authors.affiliation: Departments of Clinical Microbiology, Affiliated Yuying Children's Hospital, Wenzhou Medical College, Wenzhou 325027, China.
authors.forename: Cai-xia
authors.initials: CX
authors.lastname: Liu
authors.forename: Jin-hong
authors.initials: JH
authors.lastname: Yang
authors.forename: Lin
authors.initials: L
authors.lastname: Dong
authors.forename: Jing-yun
authors.initials: JY
authors.lastname: Mai
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.forename: Jiang-hu
authors.initials: JH
authors.lastname: Zhu
mesh_terms: D003428:Cross Infection / Q000382:microbiology* / Q000628:therapy; D005260:Female; D016469:Fungemia / Q000382:microbiology* / Q000628:therapy; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010843:Pichia / Q000235:genetics / Q000302:isolation & purification*; D012189:Retrospective Studies