title: Synthetic biology: tools to design microbes for the production of chemicals and fuels.
abstract: The engineering of biological systems to achieve specific purposes requires design tools that function in a predictable and quantitative manner. Recent advances in the field of synthetic biology, particularly in the programmable control of gene expression at multiple levels of regulation, have increased our ability to efficiently design and optimize biological systems to perform designed tasks. Furthermore, implementation of these designs in biological systems highlights the potential of using these tools to build microbial cell factories for the production of chemicals and fuels. In this paper, we review current developments in the design of tools for controlling gene expression at transcriptional, post-transcriptional and post-translational levels, and consider potential applications of these tools.
authors.affiliation: Department of Chemical Engineering, Pohang University of Science and Technology, San 31, Hyoja-dong, Nam-gu, Pohang, Gyeongbuk 790-784, Republic of Korea.
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Seo
authors.forename: Jina
authors.initials: J
authors.lastname: Yang
authors.forename: Byung Eun
authors.initials: BE
authors.lastname: Min
authors.forename: Sungho
authors.initials: S
authors.lastname: Jang
authors.forename: Jae Hyung
authors.initials: JH
authors.lastname: Lim
authors.forename: Hyun Gyu
authors.initials: HG
authors.lastname: Lim
authors.forename: Seong Cheol
authors.initials: SC
authors.lastname: Kim
authors.forename: Se Yeon
authors.initials: SY
authors.lastname: Kim
authors.forename: Jun Hong
authors.initials: JH
authors.lastname: Jeong
authors.forename: Gyoo Yeol
authors.initials: GY
authors.lastname: Jung
mesh_terms: D056804:Biofuels / Q000382:microbiology; D001709:Biotechnology; D005285:Fermentation / Q000235:genetics; D005818:Genetic Engineering / Q000379:methods; D007218:Industrial Microbiology / Q000706:statistics & numerical data* / Q000639:trends; D058615:Synthetic Biology / Q000639:trends*; D049490:Systems Biology / Q000639:trends*
chemical_list: D056804:Biofuels
keywords: Biochemical; Biofuel; Expression control; Metabolic engineering; Microbial cell factory; Synthetic biology