title: Anin vitro-in vivomodel of epithelial mesenchymal transition in triple negative breast cancer.
abstract: The loss of epithelial expression markers by neoplastic breast cancer cells in the primary tumor is believed to play a pivotal role during breast cancer metastasis. This phenomenon is the hallmark of the epithelial mesenchymal transition (EMT) process. Gene expression microarrays were performed to investigate key functional elements on anin vitrometastasis model derived from human breast epithelial cells (MCF10F) treated with 17 beta estradiol. We identified groups of SLUG associated genes modulated during EMT.
authors.affiliation: Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
authors.forename: Yubo
authors.initials: Y
authors.lastname: Zhai
authors.forename: Julia
authors.initials: J
authors.lastname: Santucci-Pereira
authors.forename: Ricardo Lopez
authors.initials: RL
authors.lastname: de Cicco
authors.forename: Irma H
authors.initials: IH
authors.lastname: Russo
authors.forename: Jose
authors.initials: J
authors.lastname: Russo