title: Distal fibula metastasis of cholangiocarcinoma.
abstract: Cholangiocarcinoma is a rare disease with a reported incidence in the United States of 1 to 2 cases per 100,000 population. These cancers have a high mortality rate because most are locally advanced at presentation. Cholangiocarcinoma most commonly advances locally and regionally by invading the lymph nodes. In rare cases, it has been noted that cholangiocarcinoma can metastasize to bone, with a preponderance for the axial skeleton. Herein, we describe what we believe to be the first clinical report of an acral bone metastasis from metastatic cholangiocarcinoma.
authors.affiliation: Rothman Institute, Philadelphia, PA 19107, USA.
authors.forename: Homyar
authors.initials: H
authors.lastname: Karanjia
authors.forename: John A
authors.initials: JA
authors.lastname: Abraham
authors.forename: Brian
authors.initials: B
authors.lastname: O'Hara
authors.forename: Brandon
authors.initials: B
authors.lastname: Shallop
authors.forename: Joseph
authors.initials: J
authors.lastname: Daniel
authors.forename: Nicholas
authors.initials: N
authors.lastname: Taweel
authors.forename: Faith A
authors.initials: FA
authors.lastname: Schick
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D018281:Cholangiocarcinoma / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary*; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D005360:Fibula / Q000473:pathology*; D050723:Fractures, Bone / Q000517:prevention & control; D006801:Humans; D008279:Magnetic Resonance Imaging
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates
keywords: 4; biopsy; cancer; carcinoma; liver; surgery; tumor