title: Knockdown of ZFX inhibits gastric cancer cell growth in vitro and in vivo via downregulating the ERK-MAPK pathway.
abstract: Zinc finger protein X-linked (ZFX) is a zinc finger transcription factor encoded on the X chromosome. Here, we found that ZFX expression was significantly upregulated in gastric cancer (GC) cell lines and tissues. Knockdown of ZFX induced significant apoptosis and cell cycle arrest in SGC7901 and MGC803 cells. Moreover, we demonstrated for the first time that knockdown of ZFX inhibited gastric cancer cell growth in vitro and in vivo via downregulating the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK-MAPK) pathway. Therefore, ZFX play a prominent role in GC tumorigenicity and may have potential applications in the diagnosis or treatment of GC.
authors.affiliation: GI Division, Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai Institution of Digestive Disease, Shanghai 200001, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Wu
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Lao
authors.forename: Tian-Tian
authors.initials: TT
authors.lastname: Sun
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Ren
authors.forename: Xuan
authors.initials: X
authors.lastname: Kong
authors.forename: Ji-Lin
authors.initials: JL
authors.lastname: Wang
authors.forename: Ying-Chao
authors.initials: YC
authors.lastname: Wang
authors.forename: Wan
authors.initials: W
authors.lastname: Du
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Yu
authors.forename: Yu-Rong
authors.initials: YR
authors.lastname: Weng
authors.forename: Jie
authors.initials: J
authors.lastname: Hong
authors.forename: Jing-Yuan
authors.initials: JY
authors.lastname: Fang
mesh_terms: D000818:Animals; D017209:Apoptosis; D059447:Cell Cycle Checkpoints; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015536:Down-Regulation; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D005260:Female; D055785:Gene Knockdown Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D034622:RNA Interference; D013274:Stomach Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D013997:Time Factors; D014162:Transfection; D047368:Tumor Burden
chemical_list: D051741:Kruppel-Like Transcription Factors; C062076:zinc finger protein, X-linked; D048049:Extracellular Signal-Regulated MAP Kinases
keywords: ERK-MAPK; Gastric cancer (GC); Zinc finger protein X-linked (ZFX)