title: The schlafen family of proteins and their regulation by interferons.
abstract: The Schlafen (SLFN) family of proteins includes several mouse and human members. There is emerging evidence that members of this family of proteins are involved in important functions, such as the control of cell proliferation, induction of immune responses, and the regulation of viral replication. These proteins span across all species with great diversity, with 10 murine and 5 human isoforms. Recent work has established that mouse and human SLFN proteins are regulated by interferons (IFNs). Several Slfn genes were shown to be induced as classical interferon-stimulated genes, and emerging evidence suggests that these proteins play important roles in the growth inhibitory and antineoplastic effects of IFNs. In the current review, the known properties of mouse and human SLFNs are reviewed, and the implications of their emerging functions are discussed.
authors.affiliation: Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA.
authors.forename: Evangelos
authors.initials: E
authors.lastname: Mavrommatis
authors.forename: Eleanor N
authors.initials: EN
authors.lastname: Fish
authors.forename: Leonidas C
authors.initials: LC
authors.lastname: Platanias
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism*; D049109:Cell Proliferation; D006801:Humans; D007372:Interferons / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D009687:Nuclear Proteins / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction; D047908:Intracellular Signaling Peptides and Proteins
chemical_list: D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D007372:Interferons; D009687:Nuclear Proteins; D011506:Proteins; C576668:SLFN11 protein, human; C554861:SLFN5 protein, human; C504818:schlafen-1 protein, mouse; C521352:schlafen-2 protein, mouse; C559915:schlafen-4 protein, mouse; C000656172:SLFN12 protein, human; D047908:Intracellular Signaling Peptides and Proteins