title: MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis.
abstract: Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. In particular, miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux. Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS.
authors.affiliation: Blood-Brain Barrier Research Group, Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
authors.forename: Arie
authors.initials: A
authors.lastname: Reijerkerk
authors.forename: M Alejandro
authors.initials: MA
authors.lastname: Lopez-Ramirez
authors.forename: Bert
authors.initials: B
authors.lastname: van Het Hof
authors.forename: Joost A R
authors.initials: JA
authors.lastname: Drexhage
authors.forename: Wouter W
authors.initials: WW
authors.lastname: Kamphuis
authors.forename: Gijs
authors.initials: G
authors.lastname: Kooij
authors.forename: Joost B
authors.initials: JB
authors.lastname: Vos
authors.forename: Tineke C T M
authors.initials: TC
authors.lastname: van der Pouw Kraan
authors.forename: Anton J
authors.initials: AJ
authors.lastname: van Zonneveld
authors.forename: Anton J
authors.initials: AJ
authors.lastname: Horrevoets
authors.forename: Alexandre
authors.initials: A
authors.lastname: Prat
authors.forename: Ignacio A
authors.initials: IA
authors.lastname: Romero
authors.forename: Helga E
authors.initials: HE
authors.lastname: de Vries
mesh_terms: D001812:Blood-Brain Barrier / Q000187:drug effects / Q000503:physiopathology*; D001921:Brain / Q000473:pathology*; D002461:Cell Line, Transformed; D016207:Cytokines / Q000378:metabolism; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects; D005822:Genetic Vectors / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000473:pathology*; D034741:RNA, Small Interfering / Q000494:pharmacology; D057705:Transendothelial and Transepithelial Migration / Q000187:drug effects; D014162:Transfection
chemical_list: D016207:Cytokines; D035683:MicroRNAs; D034741:RNA, Small Interfering