title: Evaluation of right and left ventricular diastolic filling.
abstract: A conceptual fluid-dynamics framework for diastolic filling is developed. The convective deceleration load (CDL) is identified as an important determinant of ventricular inflow during the E wave (A wave) upstroke. Convective deceleration occurs as blood moves from the inflow anulus through larger-area cross-sections toward the expanding walls. Chamber dilatation underlies previously unrecognized alterations in intraventricular flow dynamics. The larger the chamber, the larger becomes the endocardial surface and the CDL. CDL magnitude affects strongly the attainable E wave (A wave) peak. This underlies the concept of diastolic ventriculoannular disproportion. Large vortices, whose strength decreases with chamber dilatation, ensue after the E wave peak and impound inflow kinetic energy, averting an inflow-impeding, convective Bernoulli pressure rise. This reduces the CDL by a variable extent depending on vortical intensity. Accordingly, the filling vortex facilitates filling to varying degrees, depending on chamber volume. The new framework provides stimulus for functional genomics research, aimed at new insights into ventricular remodeling.
authors.affiliation: Department of Surgery, Duke University School of Medicine, HAFS-7th floor, DUMC 3704, Durham, NC 27710, USA. apasipou@duke.edu
authors.forename: Ares
authors.initials: A
authors.lastname: Pasipoularides
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D003971:Diastole; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D023281:Genomics; D006333:Heart Failure / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000235:genetics / Q000503:physiopathology*; D017380:Hypertrophy, Right Ventricular / Q000235:genetics / Q000503:physiopathology*; D008955:Models, Cardiovascular; D010641:Phenotype; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000235:genetics / Q000503:physiopathology*; D018497:Ventricular Dysfunction, Right / Q000235:genetics / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000235:genetics; D016278:Ventricular Function, Right / Q000235:genetics; D017725:Ventricular Pressure; D020257:Ventricular Remodeling