title: [Innervation of the intervertebral disc].
abstract: Until very recently, intervertebral disc innervation was a subject of considerable debate. Nowadays, the introduction of inmunohistochemical techniques associated to specific antibodies and studies with retrograde tracers in nerves have allowed greater understanding of disc innervation in physiological and pathological conditions and also endings characteristics and their patterns of distribution in both situations. The existing controversies regarding structural basis of discogenic pain, have raised the interest of knowing the influence of innervation in back pain from discal origin and its characteristics. Today, we know that pathologic neoinnervation accompanying radial fissures is an important factor in the genesis of discogenic pain; within a complex mechanism in which other neurobiomechemical, inflammatory and biomechanical factors are involved.
authors.affiliation: Servicio de Neurocirugía, Complejo Asistencial Universitario de León, León, España. Electronic address: jcosamalon@smonica.com.
authors.forename: José
authors.initials: J
authors.lastname: García-Cosamalón
authors.forename: Javier
authors.initials: J
authors.lastname: Fernández-Fernández
authors.forename: Emilio
authors.initials: E
authors.lastname: González-Martínez
authors.forename: Javier
authors.initials: J
authors.lastname: Ibáñez-Plágaro
authors.forename: Javier
authors.initials: J
authors.lastname: Robla Costales
authors.forename: Milton
authors.initials: M
authors.lastname: Martínez-Madrigal
authors.forename: Alfonso
authors.initials: A
authors.lastname: López Muñíz
authors.forename: Miguel Enrique
authors.initials: ME
authors.lastname: del Valle
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Vega
mesh_terms: D000320:Adrenergic Fibers / Q000502:physiology; D001416:Back Pain / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation; D018836:Inflammation Mediators / Q000502:physiology; D007403:Intervertebral Disc / Q000294:innervation*; D007405:Intervertebral Disc Displacement / Q000196:embryology / Q000209:etiology / Q000503:physiopathology; D008465:Mechanoreceptors / Q000502:physiology; D009414:Nerve Growth Factors / Q000502:physiology; D009619:Nociceptors / Q000502:physiology; D011984:Sensory Receptor Cells / Q000502:physiology
chemical_list: D018836:Inflammation Mediators; D009414:Nerve Growth Factors