title: Inhibition of Ras-Effector Interaction by Cyclic Peptides.
abstract: A combinatorial library of 6 × 106cyclic peptides was synthesized in the one bead-two compound format, with each bead displaying a unique cyclic peptide on its surface and a linear peptide encoding tag in its interior. Screening of the library against K-Ras identified compounds that bound K-Ras with submicromolar affinity and disrupted its interaction with effector proteins.
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, 100 West 18 Avenue, Columbus, OH 43210, U. S. A. ; Tel: 614-688-4068.
authors.forename: Xianghong
authors.initials: X
authors.lastname: Wu
authors.forename: Punit
authors.initials: P
authors.lastname: Upadhyaya
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Villalona-Calero
authors.forename: Roger
authors.initials: R
authors.lastname: Briesewitz
authors.forename: Dehua
authors.initials: D
authors.lastname: Pei