title: Plasmonic fluorescence enhancement by metal nanostructures: shaping the future of bionanotechnology.
abstract: This review focuses on metal enhanced fluorescence (MEF) and its current and future applications in biotechnology. The mechanisms of MEF are discussed in terms of the additional radiative and nonradiative decay rates caused by the close proximity of the metal. We then review the current MEF materials and structures that show promise in bioapplications. The use of electromagnetic modelling to predict fluorescent rate enhancement is then considered. We then give particular focus to the recent work carried out in the homogeneous fabrication of metal nanoparticles using colloidal lithography. It is concluded that the use of computational electromagnetic modelling alongside homogeneous fabrication techniques will lead to predictable and controllable MEF, paving the way for increased applications in biotechnology.
authors.affiliation: Department of Materials and London Centre for Nanotechnology, Imperial College London, London, UKSW7 2AZ. f.xie@imperial.ac.uk.
authors.forename: Daniel
authors.initials: D
authors.lastname: Darvill
authors.forename: Anthony
authors.initials: A
authors.lastname: Centeno
authors.forename: Fang
authors.initials: F
authors.lastname: Xie
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001709:Biotechnology; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D007118:Immunoassay; D008670:Metals / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D013050:Spectrometry, Fluorescence
chemical_list: D015415:Biomarkers; D005456:Fluorescent Dyes; D008670:Metals