title: Cell biology: Notch recycling is numbed.
abstract: During asymmetric cell division, the Notch regulator Numb segregates unequally to establish different cell fates in the two daughter cells. Numb is thought to act as an endocytic protein. Two new studies show that Numb antagonizes Notch signaling by also regulating recycling of Sanpodo-Notch complexes via AP-1.
authors.affiliation: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria.
authors.forename: Ilka
authors.initials: I
authors.lastname: Reichardt
authors.forename: Jürgen A
authors.initials: JA
authors.lastname: Knoblich
mesh_terms: D000818:Animals; D060049:Asymmetric Cell Division / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins / Q000378:metabolism* / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism*; D007605:Juvenile Hormones / Q000378:metabolism* / Q000502:physiology*; D008840:Microfilament Proteins / Q000378:metabolism; D051880:Receptors, Notch / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D007605:Juvenile Hormones; D008840:Microfilament Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch; C060606:numb protein, Drosophila; C112833:spdo protein, Drosophila