title: microRNA-mediated regulation of innate immune response in rheumatic diseases.
abstract: miRNAs have been shown to play essential regulatory roles in the innate immune system. They function at multiple levels to shape the innate immune response and maintain homeostasis by direct suppression of the expression of their target proteins, preferentially crucial signaling components and transcription factors. Studies in humans and in disease models have revealed that dysregulation of several miRNAs such as miR-146a and miR-155 in rheumatic diseases leads to aberrant production of and/or signaling by inflammatory cytokines and, thus, critically contributes to disease pathogenesis. In addition, the recent description of the role of certain extracellular miRNAs as innate immune agonist to induce inflammatory response would have direct relevance to rheumatic diseases.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Luo
authors.forename: Koustubh
authors.initials: K
authors.lastname: Ranade
authors.forename: Ronel
authors.initials: R
authors.lastname: Talker
authors.forename: Bahija
authors.initials: B
authors.lastname: Jallal
authors.forename: Nan
authors.initials: N
authors.lastname: Shen
authors.forename: Yihong
authors.initials: Y
authors.lastname: Yao
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics* / Q000276:immunology; D035683:MicroRNAs / Q000276:immunology*; D012216:Rheumatic Diseases / Q000235:genetics* / Q000276:immunology*
chemical_list: D035683:MicroRNAs