title: Laser speckle imaging based on intensity fluctuation modulation.
abstract: We present a method, intensity fluctuation modulation (IFM), to obtain a full-field laser speckle microvessel image. Different from laser speckle contrast analysis, IFM imaging is insensitive to flow velocity and can be used to reconstruct microvessel images with higher spatial resolution and SNR. An in vivo animal experiment on a mouse pinna is conducted to demonstrate that IFM imaging is capable of achieving laser speckle microangiography.
authors.affiliation: Department of Physics and Applied Optics Beijing Area Major Laboratory, Beijing Normal University, Beijing 100875, China.
authors.forename: Yaguang
authors.initials: Y
authors.lastname: Zeng
authors.forename: Mingyi
authors.initials: M
authors.lastname: Wang
authors.forename: Guangping
authors.initials: G
authors.lastname: Feng
authors.forename: Xianjun
authors.initials: X
authors.lastname: Liang
authors.forename: Guojian
authors.initials: G
authors.lastname: Yang
mesh_terms: D000818:Animals; D054644:Ear Auricle / Q000098:blood supply; D007834:Lasers; D051379:Mice; D055806:Microvessels / Q000166:cytology; D057054:Molecular Imaging / Q000379:methods*