title: Preparing of pellets by extrusion/spheronization using different types of equipment and process conditions.
abstract: BACKGROUND
  The focus of this work was to produce matrix pellets made by extrusion/ spheronization using two types of equipment. The aim was to accomplish the laboratory-scale I process that has been already optimized and accepted with another type of equipment (laboratory-scale II).
  
  
  METHODS
  A matrix pellet formulation consisting of MCC, Eudragit NE 30D and diclofenac sodium was used in the two types of equipment. Physico-chemical parameters and the dissolution profiles of the pellets in phosphate buffer pH 6.8 were compared.
  
  
  RESULTS
  Pellets from both processes were similar in shape and tensile strength. They differed in particle size and dissolution profile. This may be contributed to different spheronization conditions.
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged , Szeged , Hungary and.
authors.forename: Éva
authors.initials: É
authors.lastname: Bölcskei
authors.forename: Géza
authors.initials: G
authors.lastname: Regdon
authors.forename: Tamás
authors.initials: T
authors.lastname: Sovány
authors.forename: Dima
authors.initials: D
authors.lastname: Ghanam
authors.forename: Klaus
authors.initials: K
authors.lastname: Knop
authors.forename: Peter
authors.initials: P
authors.lastname: Kleinebudde
authors.forename: Klára
authors.initials: K
authors.lastname: Pintye-Hódi
mesh_terms: D004008:Diclofenac / Q000737:chemistry*; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods; D004343:Drug Implants; D065546:Drug Liberation; D004867:Equipment Design; D005079:Excipients / Q000737:chemistry*; D007091:Image Processing, Computer-Assisted; D010316:Particle Size; D011208:Powders; D013499:Surface Properties
chemical_list: D004343:Drug Implants; D005079:Excipients; D011208:Powders; D004008:Diclofenac
keywords: Aspect ratio; dissolution; extrusion/spheronization; pellets; tensile strength