title: Antifungal activity of Aegle marmelos (L.) Correa (Rutaceae) leaf extract on dermatophytes.
abstract: OBJECTIVE
  To evaluate the in vitro antifungal activity of Aegle marmelos leaf extracts and fractions on the clinical isolates of dermatophytic fungi like Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis, Microsporum gypseum and Epidermophyton floccosum.
  
  
  METHODS
  The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of various extracts and fractions of the leaves of Aegle marmelos were measured using method of National Committee for Clinical Laboratory Standards (NCCLS).
  
  
  RESULTS
  Aegle marmelos leaf extracts and fractions were found to have fungicidal activity against various clinical isolates of dermatophytic fungi. The MIC and MFC was found to be high in water and ethyl alcohol extracts and methanol fractions (200µg/mL) against dermatophytic fungi studied.
  
  
  CONCLUSIONS
  Aegle marmelos leaf extracts significantly inhibites the growth of all dermatophytic fungi studied. If this activity is confirmed by in vivo studies and if the compound is isolated and identified, it could be a remedy for dermatophytosis.
authors.affiliation: Department of Chemistry and Biosciences, SASTRA University, Srinivasa Ramanujan Centre, Kumbakonam- 612001, Tamil Nadu, India.
authors.forename: S
authors.initials: S
authors.lastname: Balakumar
authors.forename: S
authors.initials: S
authors.lastname: Rajan
authors.forename: T
authors.initials: T
authors.lastname: Thirunalasundari
authors.forename: S
authors.initials: S
authors.lastname: Jeeva
mesh_terms: D045471:Aegle / Q000737:chemistry*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects* / Q000254:growth & development; D004821:Epidermophyton / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D008864:Microsporum / Q000187:drug effects / Q000254:growth & development; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D014249:Trichophyton / Q000187:drug effects / Q000254:growth & development
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts
keywords: Aegle marmelos; Antifungal activity; Dermatophytes; Dermatophytosis