title: Palladium-catalyzed cascade reactions of 1-(3-arylprop-2-ynyloxy)-2-bromo benzene derivatives with organoboron compounds.
abstract: Applications of the cascade cyclocarbopalladation reaction followed by Suzuki-Miyaura coupling reactions of the readily available aryl-substituted propargylic aryl ethers with arylboronic acid and potassium trans-β-styryltrifluoroborate accomplish a new versatile entry in the synthesis of benzofuran derivatives. Notably, a new approach to the challenging synthesis of C3 functionalized 2-unsubstituted benzofurans has been developed by a cyclocarbopalladation/cross-coupling/aromatization process.
authors.affiliation: Dipartimento di Scienze Fisiche e Chimiche, Università di L'Aquila, Via Vetoio, 67010, Coppito (AQ), Italy. antonio.arcadi@univaq.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Arcadi
authors.forename: Federico
authors.initials: F
authors.lastname: Blesi
authors.forename: Sandro
authors.initials: S
authors.lastname: Cacchi
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Fabrizi
authors.forename: Antonella
authors.initials: A
authors.lastname: Goggiamani
authors.forename: Fabio
authors.initials: F
authors.lastname: Marinelli
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D001896:Boron Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004987:Ethers / Q000737:chemistry; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001572:Benzofurans; D001896:Boron Compounds; D004987:Ethers; D006842:Hydrocarbons, Brominated; D009942:Organometallic Compounds; C531209:propargyl ether; D010165:Palladium