title: Analysis of anti-Clostridium difficile activity of thuricin CD, vancomycin, metronidazole, ramoplanin, and actagardine, both singly and in paired combinations.
abstract: Due to the ongoing problem of recurrence of Clostridium difficile-associated diarrhea following antibiotic treatment, there is an urgent need for alternative treatment options. We assessed the MICs of five antimicrobials singly and in combinations against a range of C. difficile clinical isolates. Ramoplanin-actagardine combinations were particularly effective, with partial synergistic/additive effects observed against 61.5% of C. difficile strains tested.
authors.affiliation: Department of Microbiology, University College Cork, Cork, Ireland.
authors.forename: Harsh
authors.initials: H
authors.lastname: Mathur
authors.forename: Paula M
authors.initials: PM
authors.lastname: O'Connor
authors.forename: Colin
authors.initials: C
authors.lastname: Hill
authors.forename: Paul D
authors.initials: PD
authors.lastname: Cotter
authors.forename: R Paul
authors.initials: RP
authors.lastname: Ross
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001430:Bacteriocins / Q000494:pharmacology* / Q000627:therapeutic use; D016360:Clostridioides difficile / Q000187:drug effects* / Q000302:isolation & purification; D047630:Depsipeptides / Q000494:pharmacology* / Q000627:therapeutic use; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests / Q000592:standards; D010455:Peptides / Q000494:pharmacology* / Q000627:therapeutic use; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D047630:Depsipeptides; D010455:Peptides; C041438:ramoplanin; D008795:Metronidazole; C059740:thuricin; C012993:gardimycin; D014640:Vancomycin