title: Familial eruptive syringomas: case report and review of the literature.
abstract: BACKGROUND
  Syringomas are benign neoplasms of eccrine origin. A clinical variant is eruptive syringomas, which presents as firm, smooth, yellow to pigmented papules that appear as successive crops on the neck, axillae, chest, abdomen, and/or periumbilical region. To our knowledge, there are only 10 published reports of familial eruptive syringomas. Herein we describe the eleventh report of familial eruptive syringomas, review the literature on this unusual presentation, and suggest a novel classification of familial syringomas based on our literature review.
  
  
  METHODS
  We report two cases of eruptive syringoma within a family. Eruptive syringomas were widely distributed on the trunk of a healthy 16-year-old female and her 19-year-old brother. Both the 19-year-old man and his mother also had infraorbital syringomas.
  
  
  CONCLUSIONS
  Familial eruptive syringomas are a rare clinical entity that is likely autosomal dominantly inherited. Future reports of this unusual condition may provide further insight into the etiology of familial syringomas, and genetic analysis of cases may enable the causative gene mutation to be determined.
authors.affiliation: Faculty of Medicine and the Division of Dermatology, University of Calgary, Calgary, AB.
authors.forename: Jenny
authors.initials: J
authors.lastname: Lau
authors.forename: Richard M
authors.initials: RM
authors.lastname: Haber
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D013544:Sweat Gland Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D018252:Syringoma / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D055815:Young Adult