title: Enantioselective synthesis of 4-aminopyrrolidine-2,4-dicarboxylate derivatives via Ag-catalyzed cycloaddition of azomethine ylides with alkylidene azlactones.
abstract: A catalytic highly enantioselective silver-DTBM-segphos catalyzed cycloaddition of α-iminoesters with alkylidene azlactones is reported. This procedure provides an effective access to 4-aminopyrrolidine-2,4-dicarboxylate derivatives with high diastereo- and enantioselectivity.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: González-Esguevillas
authors.forename: Javier
authors.initials: J
authors.lastname: Adrio
authors.forename: Juan C
authors.initials: JC
authors.lastname: Carretero
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D061565:Cycloaddition Reaction; D003998:Dicarboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013237:Stereoisomerism; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D003998:Dicarboxylic Acids; D007783:Lactones; D011759:Pyrrolidines; D013882:Thiosemicarbazones; C512188:azomethine; D012834:Silver