title: Triglyceride-to-HDL cholesterol ratio. Predictive value for CHD severity and new-onset heart failure.
abstract: OBJECTIVE
  This study aimed to explore the association between the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and the severity of coronary heart disease (CHD). It also evaluated the clinical role of the TG/HDL-C ratio in predicting in-hospital CHD events and the long-term prognosis of CHD patients.
  
  
  METHODS
  According to the results of coronary angiography examinations, 317 patients were enrolled in the study and classified into a CHD group (n=233) and a control group (n=84). The TG/HDL-C ratio was calculated at baseline. The CHD group was then further classified into cases of single-branch stenosis (n=79), double-branch stenosis (n=73), and multi-branch stenosis (n=81). The Gensini score was calculated for each group to analyze the relationship between the TG/HDL-C ratio and the severity of CHD.
  
  
  RESULTS
  The TG/HDL-C ratio in the CHD group was significantly higher than in the normal group (P < 0.001). The TG/HDL-C ratio was positively correlated with the Gensini score. The ratio was significantly higher in patients with new-onset heart failure than in those without heart failure events (P < 0.05). An average 3-year follow-up showed that the serum TG/HDL-C ratios of patients with adverse events were significantly higher than other patients (P <  0.01).
  
  
  CONCLUSIONS
  The TG/HDL-C ratio is predictive of the severity of CHD. It could also help predict in-hospital new-onset heart failure incidents of CHD patients.
authors.affiliation: Department of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, Ruijin 2nd Road, Shanghai, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Yunke
authors.forename: L
authors.initials: L
authors.lastname: Guoping
authors.forename: C
authors.initials: C
authors.lastname: Zhenyue
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D015984:Causality; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood*; D015897:Comorbidity; D003327:Coronary Disease / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016019:Survival Analysis; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D014280:Triglycerides