title: Large-scale aqueous synthesis of fluorescent and biocompatible silicon nanoparticles and their use as highly photostable biological probes.
abstract: A large-scale synthetic strategy is developed for facile one-pot aqueous synthesis of silicon nanoparticles (SiNPs) yielding ∼0.1 g SiNPs of small sizes (∼2.2 nm) in 10 min. The as-prepared SiNPs feature strong fluorescence (photoluminescence quantum yield of 20-25%), favorable biocompatibility, and robust photo- and pH-stability. Moreover, the SiNPs are naturally water dispersible, requiring no additional post-treatment. Such SiNPs can serve as highly photostable bioprobes and are superbly suitable for long-term immunofluorescent cellular imaging.
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University , Suzhou 215123, China.
authors.forename: Yiling
authors.initials: Y
authors.lastname: Zhong
authors.forename: Fei
authors.initials: F
authors.lastname: Peng
authors.forename: Feng
authors.initials: F
authors.lastname: Bao
authors.forename: Siyi
authors.initials: S
authors.lastname: Wang
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Ji
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Su
authors.forename: Shuit-Tong
authors.initials: ST
authors.lastname: Lee
authors.forename: Yao
authors.initials: Y
authors.lastname: He
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007150:Immunohistochemistry; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D055668:Photochemical Processes; D012825:Silicon / Q000737:chemistry*; D013499:Surface Properties; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D005456:Fluorescent Dyes; D014867:Water; D012825:Silicon