title: The effect of perioperative ibuprofen use on tooth sensitivity caused by in-office bleaching.
abstract: OBJECTIVE
  This study determined the effect of the administration of perioperative ibuprofen 400 mg on tooth sensitivity caused by in-office bleaching.
  
  
  METHODS
  A triple-blind, parallel-design, randomized clinical trial was conducted on 30 adults who received placebo or ibuprofen before and after bleaching. The drugs were administered three times per day for 48 hours; the first dose was given one hour prior to the bleaching treatment. Two bleaching sessions with 35% hydrogen peroxide gel were performed with a one-week interval. Tooth sensitivity was recorded on two scales: visual analogue and five-point verbal rating scale up to 48 hours after bleaching. The shade evaluation was performed with a visual shade guide and spectrophotometer, before and 30 days after bleaching. The absolute risk of tooth sensitivity and its intensity were evaluated by Fisher exact and Mann-Whitney tests, respectively. The shade changes were evaluated by Student's t-test.
  
  
  RESULTS
  Both groups showed similar absolute risk of tooth sensitivity (p>0.05). Lower tooth sensitivity was observed in the experimental group only up to one hour postbleaching (p=0.04). Similar tooth sensitivity was observed in the other periods of time.
  
  
  CONCLUSIONS
  The perioperative use of the anti-inflammatory ibuprofen was not able to avoid tooth sensitivity but reduced its intensity up to one hour after bleaching.
authors.forename: E
authors.initials: E
authors.lastname: Paula
authors.forename: S
authors.initials: S
authors.lastname: Kossatz
authors.forename: D
authors.initials: D
authors.lastname: Fernandes
authors.forename: A
authors.initials: A
authors.lastname: Loguercio
authors.forename: A
authors.initials: A
authors.lastname: Reis
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000209:etiology / Q000517:prevention & control*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000627:therapeutic use; D007052:Ibuprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010147:Pain Measurement; D059035:Perioperative Period; D014073:Tooth Bleaching / Q000009:adverse effects*; D014075:Tooth Discoloration / Q000628:therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006861:Hydrogen Peroxide; D007052:Ibuprofen