title: Genetic susceptibility loci, pesticide exposure and prostate cancer risk.
abstract: Uncovering SNP (single nucleotide polymorphisms)-environment interactions can generate new hypotheses about the function of poorly characterized genetic variants and environmental factors, like pesticides. We evaluated SNP-environment interactions between 30 confirmed prostate cancer susceptibility loci and 45 pesticides and prostate cancer risk in 776 cases and 1,444 controls in the Agricultural Health Study. We used unconditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Multiplicative SNP-pesticide interactions were calculated using a likelihood ratio test. After correction for multiple tests using the False Discovery Rate method, two interactions remained noteworthy. Among men carrying two T alleles at rs2710647 in EH domain binding protein 1 (EHBP1) SNP, the risk of prostate cancer in those with high malathion use was 3.43 times those with no use (95% CI: 1.44-8.15) (P-interaction= 0.003). Among men carrying two A alleles at rs7679673 in TET2, the risk of prostate cancer associated with high aldrin use was 3.67 times those with no use (95% CI: 1.43, 9.41) (P-interaction= 0.006). In contrast, associations were null for other genotypes. Although additional studies are needed and the exact mechanisms are unknown, this study suggests known genetic susceptibility loci may modify the risk between pesticide use and prostate cancer.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America. KoutrosS@mail.nih.gov
authors.forename: Stella
authors.initials: S
authors.lastname: Koutros
authors.forename: Sonja I
authors.initials: SI
authors.lastname: Berndt
authors.forename: Kathryn
authors.initials: K
authors.lastname: Hughes Barry
authors.forename: Gabriella
authors.initials: G
authors.lastname: Andreotti
authors.forename: Jane A
authors.initials: JA
authors.lastname: Hoppin
authors.forename: Dale P
authors.initials: DP
authors.lastname: Sandler
authors.forename: Meredith
authors.initials: M
authors.lastname: Yeager
authors.forename: Laurie A
authors.initials: LA
authors.lastname: Burdett
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Yuenger
authors.forename: Michael C R
authors.initials: MC
authors.lastname: Alavanja
authors.forename: Laura E
authors.initials: LE
authors.lastname: Beane Freeman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004781:Environmental Exposure; D059647:Gene-Environment Interaction; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016017:Odds Ratio; D010575:Pesticides / Q000009:adverse effects*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000473:pathology; D012306:Risk; D055815:Young Adult
chemical_list: D010575:Pesticides