title: Diffusion weighted MRI: overview and implications for rectal cancer management.
abstract: Diffusion weighted imaging (DWI) is an MRI technique that quantifies the movement of water molecules at a cellular level. As the diffusion properties of water vary in areas of necrosis, high cellularity, inflammation and fibrosis, this technique is inherently sensitive to different pathologies. Having become a well-established adjunct to standard sequences during neurological MRI, technological advances have enabled extrapolation to abdominopelvic imaging, including staging of rectal cancer. Scan acquisitions can be performed rapidly using widely available equipment and consequently there has been rapid dissemination into routine practice. However, while DWI shows promise for detecting, staging and monitoring rectal cancer response to therapy, the evidence base remains scant with no current consensus for technical protocols, interpretation or integration into rectal cancer management. Moreover, those studies available to date have a small sample size and few observers, and their results may not be generalizable to daily practice. This article outlines the physical principles of DWI, reviews the literature and suggests avenues for future research into this important technical development.
authors.affiliation: Department of Imaging, Colchester Hospital University Foundation Trust, Colchester, UK. darren.boone@colchesterhospital.nhs.uk
authors.forename: D
authors.initials: D
authors.lastname: Boone
authors.forename: S A
authors.initials: SA
authors.lastname: Taylor
authors.forename: S
authors.initials: S
authors.lastname: Halligan
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000628:therapy; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000628:therapy