title: Glycemic index treatment using Japanese foods in a girl with Lennox-Gastaut syndrome.
abstract: We introduced a low glycemic index treatment using Japanese ethnic foods to a 13-year-old girl with Lennox-Gastaut syndrome caused by tuberous sclerosis complex. She had previously refused the modified Atkins diet within 2 weeks of diet treatment because of its restrictiveness. The low glycemic index treatment was implemented by limiting the daily carbohydrate intake to 50 g of foods with a glycemic index of less than 50 relative to that of glucose, which included udon, soba, and unpolished Japonica rice with natto. One month after the initiation of the diet therapy, the clusters of tonic seizures for 30 to 60 minutes during sleep were reduced from two or three times per week to once or twice per month, and the frequent myoclonic seizures in the awake state disappeared. She has been on the diet therapy for more than 1 year, and the efficacy of the diet has been sustained. Low glycemic index treatment should be considered for patients with medication-resistant epilepsy who cannot tolerate restrictive diet therapies. Japanese ethnic foods can be used for this diet therapy.
authors.affiliation: Department of Pediatrics, Shiga Medical Center for Children, Shiga, Japan. tkumada@mccs.med.shiga-pref.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kumada
authors.forename: Ikuko
authors.initials: I
authors.lastname: Hiejima
authors.forename: Fumihito
authors.initials: F
authors.lastname: Nozaki
authors.forename: Anri
authors.initials: A
authors.lastname: Hayashi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Fujii
mesh_terms: D000293:Adolescent; D050528:Diet, Carbohydrate-Restricted; D004040:Dietary Carbohydrates; D004569:Electroencephalography; D005260:Female; D005502:Food; D038321:Glycemic Index; D006801:Humans; D008607:Intellectual Disability / Q000178:diet therapy*; D007564:Japan; D065768:Lennox Gastaut Syndrome; D012275:Oryza; D012640:Seizures / Q000178:diet therapy / Q000453:epidemiology; D013036:Spasms, Infantile / Q000178:diet therapy*; D014402:Tuberous Sclerosis / Q000150:complications; D014474:Unconsciousness / Q000209:etiology
chemical_list: D004040:Dietary Carbohydrates