title: Relationship between the preoperative body mass index and the improvement of glycolipid metabolism in Chinese type 2 diabetic patients after Roux-en-Y gastric bypass.
abstract: OBJECTIVE
  Roux-en-Y gastric bypass (RYGB) is a gastrointestinal operation for type 2 diabetic patients could significantly alleviate or even achieve complete cure with long-term maintenance. The purpose of this study was to investigate the interrelationship between the initial BMI and the postoperative improvement of glucose and lipid metabolism in Chinese type 2 diabetic patients undergoing RYGB.
  
  
  METHODS
  Retrospective analysis of a consecutive series of cases, stratified by preoperative BMI into three groups (group A, 20kg/m2≤ BMI <25kg/m2; group B, 25kg/m2 ≤BMI <30kg/m2; and group C, 30kg/m2≤ BMI <35kg/m2). RYGB was used for thirty type 2 diabetic patients. Glycometabolism and lipid metabolism indexes were detected before and 12 months after surgery.
  
  
  RESULTS
  None of the pre- and postoperative indicators of glycolipid metabolism were significantly different among the three groups. Compared to preoperative indicators, postoperative glycolipid metabolism improved in each group, especially in group B. Overall, glycemic resolution occurred in 23.3% of patients, glycemic control in 43.4% and glycemic improvement in 33.3%. Preoperatively, all groups exhibited similar high percentages of abnormal glucose metabolism indicators, and there was a significant reduction in each group postoperatively, especially in group B. These patients presented with the highest percentage of preoperative triglycerides, cholesterol and LDL. Group C had the highest percentage of preoperative abnormal HDL. Postoperatively, all groups showed a significant reduction in the percentages of abnormal lipid metabolism indicators.
  
  
  CONCLUSIONS
  There are significant resolutions of glycolipid metabolism in all the three groups after RYGB. Furthermore, group B is superior to group A and group C in the improvement of glycolipid metabolism in Chinese type 2 diabetic patients.
authors.forename: Dawei
authors.initials: D
authors.lastname: Zhang
authors.forename: Shaihong
authors.initials: S
authors.lastname: Zhu
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Mo
authors.forename: Jingwen
authors.initials: J
authors.lastname: Hao
authors.forename: Guohui
authors.initials: G
authors.lastname: Wang
authors.forename: Liyong
authors.initials: L
authors.lastname: Zhu
authors.forename: Juan
authors.initials: J
authors.lastname: Tan
authors.forename: Aizhong
authors.initials: A
authors.lastname: Liu
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D015390:Gastric Bypass; D005947:Glucose / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000032:analysis; D006017:Glycolipids / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D005947:Glucose; D006442:Glycated Hemoglobin; D006017:Glycolipids; D008055:Lipids; C517652:hemoglobin A1c protein, human