title: [Streptozotocin induction of type 2 diabetes in tree shrew].
abstract: The aim of this study was to induce type 2 diabetes in tree shrew (Tupaia belangeri chinensis). Streptozotocin (STZ), a glucosamine derivative of nitrosourea and preferentially toxic to pancreatic beta cells, has been commonly used to induce type 1 and 2 diabetes in experimental animals. Tree shrews were treated with different low doses of STZ (60, 70, and 80 mg/kg), with six control tree shrews receiving citrate buffer. After STZ injection, tree shrews displayed increased fasting blood and urine glucose, impaired oral glucose tolerance test, and disturbed lipids metabolism and renal function. However, STZ induced tree shrews showed no diabetic complications such as diabetic lactic acidosis and hyperglycemic hyperosmolar. Animals with the above type 2 diabetic-like symptoms were variable across the three groups from 66.7% to 100%, and mortality ranged from 16.7% to 33.3%. Thus, two 80 mg/kg STZ dose injections were appeared more appropriate than other doses to induce tree shrew model of type 2 diabetes. Our results demonstrated that type 2 diabetes could be induced with favorable STZ application in tree shrew.
authors.affiliation: Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Wu
authors.forename: Yun-Hai
authors.initials: YH
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Chang
authors.forename: Lin-Qiang
authors.initials: LQ
authors.lastname: Zhang
authors.forename: Sha-Sha
authors.initials: SS
authors.lastname: Liao
authors.forename: Bin
authors.initials: B
authors.lastname: Liang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004195:Disease Models, Animal; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin; D050356:Lipid Metabolism; D008297:Male; D013311:Streptozocin / Q000009:adverse effects; D014418:Tupaiidae / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013311:Streptozocin
keywords: Streptozotocin; Tree shrew; Type 2 diabetes