title: STAT3, a Poor Survival Predicator, Is Associated with Lymph Node Metastasis from Breast Cancer.
abstract: OBJECTIVE
  The aim of this study is to explore signal transducer and activator of transcription 3 (STAT3) expression in breast cancer and to analyze the detailed mechanism that STAT3 contributes to the progression of breast cancer.
  
  
  METHODS
  We retrospectively analyzed the clinicopathologic characteristics and overall survival (OS) of 140 breast cancer patients after curative surgery, and detected STAT3 expression, phosphorylated STAT3 (pSTAT3) expression, Ki-67 expression, vascular endothelial growth factor (VEGF)-C and -D expression in breast cancer tissues, and adjacent nontumor tissues. Survival analysis and relationship analysis were adopted for demonstrated the important mechanism of STAT3 contribution to progression of breast cancer.
  
  
  RESULTS
  STAT3 expression, pSTAT3 expression, Ki-67 expression, VEGF-C expression, and VEGF-D expression in breast cancer tissues were significantly higher than those in adjacent nontumor tissues, respectively. With survival analysis, only number of lymph node metastasis (N stage) was identified as the independent predictors of the OS of breast cancer patients. Besides, we demonstrated there was the most prominent correlation between STAT3 expression and lymph node metastasis in breast cancer tissues by using the multinominal regression method.
  
  
  CONCLUSIONS
  STAT3, a poor survival biomarker potential association with lymph node metastasis, was suitable for predication the OS of breast cancer patients after curative resection.
authors.affiliation: Department of Thyroid and Breast Surgery, Western China Hospital of Sichuan University, Chengdu, China.
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wang
authors.forename: Xuejuan
authors.initials: X
authors.lastname: Liu
authors.forename: Hongjiang
authors.initials: H
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Lv
authors.forename: Jingqiang
authors.initials: J
authors.lastname: Zhu
authors.forename: Bing
authors.initials: B
authors.lastname: Wei
authors.forename: Ying
authors.initials: Y
authors.lastname: Tang
keywords: Breast neoplasms; Neoplasm metastasis; Prognosis; STAT3 transcription factor