title: Anti-inflammatory activity of the leaf extacts of Gendarussa vulgaris Nees.
abstract: OBJECTIVE
  To evaluate the anti-inflammatory property of the leaf exacts of Gendarussa vulgaris (G. vulgaris) Nees.
  
  
  METHODS
  G. vulgaris Nees of the family Apocynaceae is a medium sized tree grown in semishade or no shade and is common in the Ernad and Nilambur taluks of Kerala.Various parts of this plant have been used in the treatment of ulcers, sores, inflammation, dyspepsia, healing of wounds, etc. The present study aimed at the evaluation of anti-inflammatory property of the aqueous and alcoholic extracts of the leaves by both in vitro and in vivo methods. In vitro method was estimated by human red blood cell membrane stabilisation (HRBC) method and in vivo method was estimated on the carrageenan induced paw oedima.
  
  
  RESULTS
  Both the methods showed significant anti-inflammatory property of the different extracts tested.
  
  
  CONCLUSIONS
  The alcoholic extract at a concentration of 300 mg/mL showed potent activity on comparing with the standard drug diclofenac sodium.
authors.affiliation: Al Shifa College of Pharmacy, Poonthavanam P.O, Kizhattur, Perinthalmanna, Malappuram dist, Kerala, India 679329.
authors.forename: T K Mohamed
authors.initials: TK
authors.lastname: Saleem
authors.forename: A K
authors.initials: AK
authors.lastname: Azeem
authors.forename: C
authors.initials: C
authors.lastname: Dilip
authors.forename: C
authors.initials: C
authors.lastname: Sankar
authors.forename: N V
authors.initials: NV
authors.lastname: Prasanth
authors.forename: R
authors.initials: R
authors.lastname: Duraisami
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D029062:Apocynaceae / Q000737:chemistry*; D004487:Edema / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014197:Trees / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts
keywords: Anti-inflamation; Carrageenan; Gendarussa vulgaris; HRBC