title: [Effect of high mobility group box-1 protein on immune cells and its regulatory mechanism].
abstract: High mobility group box-1 protein (HMGB1), which is a nuclear protein, participates in chromatin architecture and transcriptional regulation. When released from cells, HMGB1 also plays a well-established role as a pro-inflammatory mediator during innate immune responses to injury. In the initial stage of injury, there is a release of large quantities of early pro-inflammatory mediators to initiate or perpetuate immune responses against pathogens, but this pro-inflammatory period is transient, and it is followed by a prolonged period of immune suppression. At present, several lines of evidences have suggested that HMGB1 is a late cytokine provoking delayed endotoxin morbidity, which may enhance the production of early proinflammatory mediators, and it can contribute potently to the activation of different immune cells and play a role in the development of host cell-mediated immunity. The biology of HMGB1 has been extensively studied as a pro-inflammatory cytokine of systemic inflammation, however, this review will attempt to provide a summary of the effects of HMGB1 on different immune cells and its regulatory mechanism in acute insults.
authors.affiliation: Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Ying-Yi
authors.initials: YY
authors.lastname: Luan
authors.forename: Feng-Hua
authors.initials: FH
authors.lastname: Yao
authors.forename: Qing-Hong
authors.initials: QH
authors.lastname: Zhang
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhu
authors.forename: Ning
authors.initials: N
authors.lastname: Dong
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Yao
mesh_terms: D016207:Cytokines / Q000276:immunology; D024243:HMGB1 Protein / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation / Q000276:immunology*
chemical_list: D016207:Cytokines; D024243:HMGB1 Protein