title: Effect of supervised training on FEV1 in cystic fibrosis: a randomised controlled trial.
abstract: BACKGROUND
  Long-term exercise interventions have been shown to improve vital capacity in cystic fibrosis (CF). Yet, no data are available indicating positive effects of long-term exercise training on FEV1.
  
  
  METHODS
  39 Swiss patients with CF were randomly divided into strength training (ST, n=12), endurance training (AT, n=17) and controls (CON(CH), n=10), and also compared with age-matched Swiss (n=35) and German (n=701) CF registry data. A partially supervised training of 3×30 min/week for 6 months took place with measurements at baseline and after 3, 6, 12 and 24 months. Primary outcome was FEV1 at 6 months.
  
  
  RESULTS
  FEV1 increased significantly in both training groups compared with CON(CH) (AT:+5.8±0.95, ST:+7.4±2.5, CON(CH):-11.5±2.7% predicted, p<0.001) and both registry groups at 6 months. At 24 months, changes in favour of the training groups persisted marginally compared with CONCH, but not compared with registry data.
  
  
  CONCLUSIONS
  A partially supervised training over 6 months improved FEV1 but effects were basically gone 18 months off training. Regular long-term training should be promoted as essential part of treatment in CF.
authors.affiliation: Swiss Tropical and Public Health Institute, University of Basel, Switzerland; Institute for Social and Preventive Medicine, University of Zürich, Switzerland. Electronic address: Susi.kriemler@unibas.ch.
authors.forename: Susi
authors.initials: S
authors.lastname: Kriemler
authors.forename: Stephanie
authors.initials: S
authors.lastname: Kieser
authors.forename: Sibylle
authors.initials: S
authors.lastname: Junge
authors.forename: Manfred
authors.initials: M
authors.lastname: Ballmann
authors.forename: Alexandra
authors.initials: A
authors.lastname: Hebestreit
authors.forename: Christian
authors.initials: C
authors.lastname: Schindler
authors.forename: Christoph
authors.initials: C
authors.lastname: Stüssi
authors.forename: Helge
authors.initials: H
authors.lastname: Hebestreit
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000503:physiopathology* / Q000628:therapy*; D005081:Exercise Therapy; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D010807:Physical Endurance; D011788:Quality of Life; D055070:Resistance Training; D014797:Vital Capacity; D055815:Young Adult
keywords: AT; Aerobic training; CF; CON(CH); CON(D); Control group Germany; Control group Switzerland; Cystic fibrosis; Exercise capacity; FEV(1); FVC; Forced expiratory volume in one second; Forced vital capacity; Lung function; Maximal oxygen consumption at peak endurance; Maximal watt performance; Physical activity; Pulmonary rehabilitation; RV/TLC; Residual volume over total lung capacity; ST; Strength training; VO2(peak); VPA; Vigorous physical activity; W(max)