title: Population-based pediatric reference intervals for HbA1c, bilirubin, albumin, CRP, myoglobin and serum enzymes.
abstract: BACKGROUND
  Many previous studies on reference intervals are hampered by the inclusion of only hospital-based populations of children and adolescents.
  
  
  METHODS
  This study included 694 children, evenly distributed from 6 months to 18 years of age. They were recruited as volunteers at child care units and schools. All subjects were apparently healthy. A questionnaire on diseases and medications was filled out by parents and by the older children.
  
  
  RESULTS
  Alanine aminotransferase (ALT), albumin, aspartate aminotransferase (AST), bilirubin, conjugated bilirubin, C-reactive protein (CRP), creatine kinase (CK), Gamma-glutamyltransferase (GGT), HbA1c (mono S and IFCC calibrations), lactate dehydrogenase (LD), myoglobin and panceratic amylase were analyzed on Abbott Architect ci8200, and for HbA1c on Tosoh G7 and a mono S-system. Age- and gender-related 2.5th and 97.5th percentiles were estimated. For some analytes the differences to comparable studies were substantial.
  
  
  CONCLUSIONS
  The study gives age- and gender-specific pediatric reference intervals, measured with modern methods for a number of important analytes. The results emphasize the importance to evaluate pediatric reference intervals in different populations and ethnic groups including only healthy subjects.
authors.affiliation: Department of Pediatrics, County Hospital of Falun, Falun, Sweden.
authors.forename: Peo
authors.initials: P
authors.lastname: Rödöö
authors.forename: Peter
authors.initials: P
authors.lastname: Ridefelt
authors.forename: Mattias
authors.initials: M
authors.lastname: Aldrimer
authors.forename: Frank
authors.initials: F
authors.lastname: Niklasson
authors.forename: Jan
authors.initials: J
authors.lastname: Gustafsson
authors.forename: Dan
authors.initials: D
authors.lastname: Hellberg
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006262:Health; D006801:Humans; D007223:Infant; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009211:Myoglobin / Q000097:blood*; D055292:Pancreatic alpha-Amylases / Q000097:blood; D012016:Reference Values; D012709:Serum Albumin / Q000378:metabolism*; D012727:Sex Characteristics; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000410:Alanine Transaminase; D001219:Aspartate Aminotransferases; D001663:Bilirubin; D002097:C-Reactive Protein; D003402:Creatine Kinase; D006442:Glycated Hemoglobin; D007770:L-Lactate Dehydrogenase; D009211:Myoglobin; D055292:Pancreatic alpha-Amylases; D012709:Serum Albumin; D005723:gamma-Glutamyltransferase; C517652:hemoglobin A1c protein, human; C554782:gamma-glutamyltransferase, human