title: Functionality of fatty acid chemoreception: a potential factor in the development of obesity?
abstract: Excess dietary fat consumption is recognized as a strong contributing factor in the development of overweight and obesity. Understanding why some individuals are better than others at regulating fat intake will become increasingly important and emerging associative evidence implicates attenuated fatty acid sensing in both the oral cavity and gastrointestinal (GI) tract in the development of obesity. Functional implications of impaired fatty acid chemoreception include diminished activation of the gustatory system, the cephalic response and satiety. This review will focus on knowledge from animal and human studies supporting the existence of oral fatty acid chemoreception including putative oral detection mechanisms, and how sensitivity to fatty acids is associated with fat consumption and fatty food preference.
authors.affiliation: Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria 3125, Australia.
authors.forename: Lisa
authors.initials: L
authors.lastname: Newman
authors.forename: Rivkeh
authors.initials: R
authors.lastname: Haryono
authors.forename: Russell
authors.initials: R
authors.lastname: Keast
mesh_terms: D000818:Animals; D001069:Appetite Regulation; D004435:Eating; D005227:Fatty Acids / Q000378:metabolism*; D005247:Feeding Behavior; D006801:Humans; D009765:Obesity / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D013649:Taste / Q000235:genetics; D013650:Taste Buds / Q000378:metabolism*
chemical_list: D005227:Fatty Acids