title: hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma among East Asians: a meta-analysis.
abstract: BACKGROUND
  The hOGG1 gene encodes a DNA glycosylase enzyme responsible for DNA repair. The Ser326Cys polymorphism in this gene may influence its repair ability and thus plays a role in carcinogenesis. Several case-control studies have been conducted on this polymorphism and its relationship with the risk of hepatocellular carcinoma (HCC) among East Asians. However, their results are inconsistent.
  
  
  METHODS
  We performed a meta-analysis of published case-control studies assessing the association of the hOGG1 Ser326Cys polymorphism with HCC risk among East Asians. PubMed, EMBASE, SCI, BIOSIS, CNKI and WanFang databases were searched. A random-effect model was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). Analyses were conducted for additive, dominant and recessive genetic models.
  
  
  RESULTS
  Eight studies were identified involving 2369 cases and 2442 controls assessing the association of the hOGG1 Ser326Cys polymorphism with HCC risk among East Asians. Applying a dominant genetic model, only in the Chinese population, the Cys allele was significantly associated with increased risk of HCC (OR 1.56, 95% CI 1.12-2.17). However, two studies influenced this finding according to sensitivity analysis. Furthermore, considerable heterogeneity and bias existed among Chinese studies.
  
  
  CONCLUSIONS
  There is limited evidence to support that the hOGG1 Ser326Cys polymorphism is associated with HCC risk among East Asians. Well-designed and large-sized studies are required to determine this relationship.
authors.affiliation: Department of Infectious Diseases, Second Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wang
authors.forename: Shuangsuo
authors.initials: S
authors.lastname: Dang
authors.forename: Yaping
authors.initials: Y
authors.lastname: Li
authors.forename: Mingzhu
authors.initials: M
authors.lastname: Sun
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Jia
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Jingkun
authors.initials: J
authors.lastname: Liu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000201:enzymology* / Q000235:genetics*; D045647:DNA Glycosylases / Q000235:genetics*; D005202:Asia, Eastern; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human