title: Association between glutathione S-transferase T1 null genotype and gastric cancer risk: a meta-analysis of 48 studies.
abstract: BACKGROUND
  Glutathione S-transferases (GSTs) have proved to be involved in the detoxifying several carcinogens and may play an important role in carcinogenesis of cancer. Previous studies on the association between Glutathione S-transferase T1 (GSTT1) polymorphism and gastric cancer risk reported inconclusive results. To clarify the possible association, we conducted a meta-analysis of eligible studies.
  
  
  METHODS
  We searched in the Pubmed, Embase, and Wangfang Medicine databases for studies assessing the association between GSTT1 null genotype and gastric cancer risk. The pooled odds ratio (OR) and its 95% confidence interval (95%CI) was calculated to assess the strength of the association. A total of 48 studies with a total of 24,440 individuals were ultimately eligible for meta-analysis.
  
  
  RESULTS
  Overall, GSTT1 null genotype was significantly associated with increased risk of gastric cancer (Random-effect OR = 1.23, 95%CI 1.13-1.35, P OR <0.001, I(2) = 45.5%). Significant association was also found in Caucasians, East Asians, and Indians (P Caucasians = 0.010; P East Asians = 0.003; P Indians = 0.017). After adjusting for other confounding variables, GSTT1 null genotype was also significantly associated with increased risk of gastric cancer (Random-effect OR = 1.43, 95%CI 1.20-1.71, P OR <0.001, I(2) = 48.1%).
  
  
  CONCLUSIONS
  The meta-analysis provides strong evidence for the significant association between GSTT1 null genotype and increased risk of gastric cancer.
authors.affiliation: Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China.
authors.forename: Weiyuan
authors.initials: W
authors.lastname: Ma
authors.forename: Le
authors.initials: L
authors.lastname: Zhuang
authors.forename: Bo
authors.initials: B
authors.lastname: Han
authors.forename: Bo
authors.initials: B
authors.lastname: Tang
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D016206:Databases, Bibliographic; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000172:deficiency / Q000235:genetics*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012306:Risk; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics*; D044465:White People
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase