title: Adiponectin/leptin ratio and insulin resistance in pregnancy.
abstract: OBJECTIVE
  Pregnancy is characterized by progressive insulin resistance. The present study evaluated whether the adiponectin/leptin ratio is associated with insulin resistance in pregnancy, since this ratio has been shown to be associated with insulin resistance in obesity, type 2 diabetes mellitus, metabolic syndrome and polycystic ovary syndrome.
  
  
  METHODS
  In this cross-sectional study, adiponectin and leptin concentrations were measured in pregnant women using enzyme-linked immunosorbent assays. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR).
  
  
  RESULTS
  Mean ± SD age of the participants (n = 74) was 30.76 ± 4.27 years, mean ± SD gestational age was 26.81 ± 3.52 weeks and median body mass index (BMI) before pregnancy was 22.68 kg/m(2) (interquartile range 20.75-26.79 kg/m(2)). There was a significant correlation between the HOMA-IR and leptin concentration, but not between the HOMA-IR and adiponectin concentration. There was a significant inverse correlation between the HOMA-IR and adiponectin/leptin ratio. The adiponectin/leptin ratio was inversely correlated with BMI before pregnancy.
  
  
  CONCLUSIONS
  The adiponection/leptin ratio inversely correlates with HOMA-IR in pregnancy.
authors.affiliation: Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia. ales.skvarca@kclj.si
authors.forename: A
authors.initials: A
authors.lastname: Skvarca
authors.forename: M
authors.initials: M
authors.lastname: Tomazic
authors.forename: R
authors.initials: R
authors.lastname: Blagus
authors.forename: B
authors.initials: B
authors.lastname: Krhin
authors.forename: A
authors.initials: A
authors.lastname: Janez
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D016001:Confidence Intervals; D003710:Demography; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008954:Models, Biological; D011247:Pregnancy
chemical_list: D052242:Adiponectin; D020738:Leptin