title: Modulating water-exchange rates of lanthanide(III)-containing polyaminopolycarboxylate-type complexes using polyethylene glycol.
abstract: We have synthesized a series of Ln(III)-containing polyethylene glycol conjugates and studied the structural and electronic properties of these complexes. These studies demonstrate that polyethylene glycol can be used to fine-tune water-exchange rates of Ln(III)-containing polyaminopolycarboxylate-type complexes; this control is desirable in developing Ln(III)-containing contrast agents for magnetic resonance imaging.
authors.affiliation: Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.
authors.forename: Buddhima N
authors.initials: BN
authors.lastname: Siriwardena-Mahanama
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Allen
mesh_terms: D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D011092:Polyethylene Glycols / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D006573:Heterocyclic Compounds, 1-Ring; D028581:Lanthanoid Series Elements; D014867:Water; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D011092:Polyethylene Glycols