title: A therapy for liver failure found in the JNK yard.
abstract: In the liver, the hepatocyte mass is kept stable through a tight balance between hepatocyte death and proliferation that is frequently lost upon acute or chronic liver injury. Wuestefeld et al. (2013) now identify a potentially druggable target that enhances hepatocyte proliferation and promotes liver regeneration, thereby preventing liver failure.
authors.affiliation: Department of Surgery, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Liver Center, University of California, San Francisco, San Francisco, CA 94143, USA. willenbringh@stemcell.ucsf.edu
authors.forename: Holger
authors.initials: H
authors.lastname: Willenbring
authors.forename: Markus
authors.initials: M
authors.lastname: Grompe