title: Collaborating with the enemy: function of macrophages in the development of neoplastic disease.
abstract: Due to the profile of released mediators (such as cytokines, chemokines, growth factors, etc.), neoplastic cells modulate the activity of immune system, directly affecting its components both locally and peripherally. This is reflected by the limited antineoplastic activity of the immune system (immunosuppressive effect), induction of tolerance to neoplastic antigens, and the promotion of processes associated with the proliferation of neoplastic tissue. Most of these responses are macrophages dependent, since these cells show proangiogenic properties, attenuate the adaptive response (anergization of naïve T lymphocytes, induction of Treg cell formation, polarization of immune response towards Th2, etc.), and support invasion and metastases formation. Tumor-associated macrophages (TAMs), a predominant component of leukocytic infiltrate, "cooperate" with the neoplastic tissue, leading to the intensified proliferation and the immune escape of the latter. This paper characterizes the function of macrophages in the development of neoplastic disease.
authors.affiliation: Chair of Immunology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University of Torun, Bydgoszcz, Poland. a.eljaszewicz@cm.umk.pl
authors.forename: Andrzej
authors.initials: A
authors.lastname: Eljaszewicz
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wiese
authors.forename: Anna
authors.initials: A
authors.lastname: Helmin-Basa
authors.forename: Michal
authors.initials: M
authors.lastname: Jankowski
authors.forename: Lidia
authors.initials: L
authors.lastname: Gackowska
authors.forename: Izabela
authors.initials: I
authors.lastname: Kubiszewska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kaszewski
authors.forename: Jacek
authors.initials: J
authors.lastname: Michalkiewicz
authors.forename: Wojciech
authors.initials: W
authors.lastname: Zegarski
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents