title: Outcome of the impella device for acute mechanical circulatory support.
abstract: OBJECTIVE
  The contribution of cardiogenic shock to in-hospital mortality has not decreased significantly despite prompt revascularization, advances in medical therapy, and mechanical circulatory support. For patients in cardiogenic shock, mechanical circulatory support has been provided by a variety of devices. We report the outcome of the Impella device for acute mechanical circulatory support in cardiogenic shock in a setting of a large-volume single institution. The primary end points include survival to 30 days and recovery of native heart function and survival to 90 days and 1 year. The secondary end points include device complications.
  
  
  METHODS
  We performed a retrospective chart review of 36 consecutive patients who underwent placement of the Impella device from February 6, 2006, to December 31, 2010. The charts were evaluated for data relative to the patients' demographics, hemodynamics, operative details, 30-day outcome including the patients' native heart function recovery, and 90-day and 1-year survival.
  
  
  RESULTS
  Thirty-six consecutive patients were included in our study. The mean ± SD age was 60.3 ± 13 years, and 69% were men. The indication for placement of the Impella device included postcardiotomy cardiogenic shock in 23 patients (64%), acute myocardial infarction complicated with cardiogenic shock in 10 patients (28%), acute decompensated ischemic cardiomyopathy in 2 patients (6%), and myocarditis with cardiogenic shock in 1 patient (3%). The mean ± SD duration of the Impella support was 4.5 ± 3.9 days (range, 1-18). The 30-day survival rate was 72% (26/36), and, of those, 96% (25/26) recovered their native heart function and one (4%) was bridged to long-term left ventricular assist device (HeartMate II; Thoratec, Inc, Pleasanton, CA USA). The 90-day and 1-year survival was 64% and 61%, respectively.
  
  
  CONCLUSIONS
  The Impella devices yielded a very favorable outcome in patients with cardiogenic shock.
authors.affiliation: Department of Cardiothoracic Surgery, Robert Wood Johnson University Hospital, New Brunswick, NJ 08903, USA. Lemairan@umdnj.edu
authors.forename: Anthony
authors.initials: A
authors.lastname: Lemaire
authors.forename: Mark B
authors.initials: MB
authors.lastname: Anderson
authors.forename: Thomas
authors.initials: T
authors.lastname: Prendergast
authors.forename: Neil
authors.initials: N
authors.lastname: Stockmaster
authors.forename: Andrew
authors.initials: A
authors.lastname: Goodman
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Lozane
authors.forename: George
authors.initials: G
authors.lastname: Batsides
mesh_terms: D000368:Aged; D015331:Cohort Studies; D004867:Equipment Design; D004869:Equipment Safety; D005260:Female; D005500:Follow-Up Studies; D006353:Heart-Assist Devices; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D061214:Patient Safety; D012189:Retrospective Studies; D018570:Risk Assessment; D012770:Shock, Cardiogenic / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome