title: Otomycosis in the north of Iran: common pathogens and resistance to antifungal agents.
abstract: Otomycosis as a kind of external otitis can be caused by various species of fungi. To use the appropriate treatment, it is necessary to identify the causal agent of otomycosis. The aim of this study was to determine the pathogens that caused otomycosis and also the efficacy of different antifungal agents. 100 patients with diagnosis of otomycosis/otitis extern were entered in this study. Bacterial culture was performed by eosin methylene blue agar, blood agar; and Sabouraud dextrose agar was used to culture the fungal agents. Minimum inhibitory concentration test also was performed to determine the efficacy of Clotrimazole, Fluconazole, Ketoconazole and Nystatin on the fungal pathogens. Otomycosis was confirmed in 43% of patients by positive culture. The most prevalent fungal pathogen was Aspergillus niger which was sensitive to Clotrimazole, Fluconazole, Ketoconazole. Candida albicans was sensitive to all drugs, in which, the most sensitivity was due to fluconazole. The most frequent fungal pathogen in our otomycosis cases is A. niger, and most of fungi that caused otomycosis are sensitive to clotrimazole.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery and Research Center, Amiralmomenin Hospital, Guilan University of Medical Sciences, Rasht, Guilan, Iran.
authors.forename: Shadman
authors.initials: S
authors.lastname: Nemati
authors.forename: Rasool
authors.initials: R
authors.lastname: Hassanzadeh
authors.forename: Sina
authors.initials: S
authors.lastname: Khajeh Jahromi
authors.forename: Azimeh
authors.initials: A
authors.lastname: Delkhosh Nasrollah Abadi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000453:epidemiology; D001232:Aspergillus fumigatus / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy* / Q000453:epidemiology; D002648:Child; D002980:Climate; D003430:Cross-Sectional Studies; D003906:Developing Countries; D025141:Drug Resistance, Fungal; D005260:Female; D006801:Humans; D007492:Iran; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D059249:Otomycosis / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000935:Antifungal Agents