title: Resveratrol and related stilbenes: their anti-aging and anti-angiogenic properties.
abstract: Dietary stilbenes comprise a class of natural compounds that display significant biological activities of medicinal interest. Among them, their antioxidant, anti-aging and anti-angiogenesic properties are well established and subjects of numerous research endeavors. This mini-review aspires to account and present the literature reports published on research concerning various natural and synthetic stilbenes, such as trans-resveratrol. Special focus was given to most recent research findings, while the mechanisms underlying their anti-aging and anti-angiogenic effects as well as the respective signaling pathways involved were also presented and discussed.
authors.affiliation: Benaki Phytopathological Institute, Laboratory of Pesticides Toxicology, 8 St. Delta Street, Athens, Kifissia 14561, Greece. Electronic address: K.Kasiotis@bpi.gr.
authors.forename: Konstantinos M
authors.initials: KM
authors.lastname: Kasiotis
authors.forename: Harris
authors.initials: H
authors.lastname: Pratsinis
authors.forename: Dimitris
authors.initials: D
authors.lastname: Kletsas
authors.forename: Serkos A
authors.initials: SA
authors.lastname: Haroutounian
mesh_terms: D000375:Aging / Q000187:drug effects*; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology; D003986:Dibenzocycloheptenes / Q000494:pharmacology; D019587:Dietary Supplements; D006801:Humans; D010944:Plants / Q000737:chemistry; D012118:Resorcinols / Q000494:pharmacology; D000077185:Resveratrol; D012377:Rodentia; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D020533:Angiogenesis Inhibitors; D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D003986:Dibenzocycloheptenes; C525082:N-hydroxy-N'-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxy-benzamidine; D012118:Resorcinols; D013267:Stilbenes; C553921:amurensin G; C107773:pterostilbene; C041525:3,3',4,5'-tetrahydroxystilbene; D000077185:Resveratrol
keywords: Aging; Angiogenesis; Lifespan; Polyphenol; Resveratrol; Stilbenes