title: High CD74 expression correlates with ZAP70 expression in B cell chronic lymphocytic leukemia patients.
abstract: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries. It is characterized by heterogeneous clinical course of the disease and new prognostic factors are still needed. CD74 plays an important role in signal transduction in B cell proliferation and survival pathway. CD74 expression has been shown in solid tumors and has been connected with poor prognosis and tumor progression. The aim of the study was to evaluate the expression of CD74 in chronic lymphocytic leukemia patients with combination with other known prognostic factors. Expression of CD74 was determined in 90 patients and 28 healthy controls. CD74 expression was significantly higher in CLL group than in controls. There was positive correlation between CD74 and ZAP70 expression (p = 0.008). High expression of CD74 was positively correlated with more advanced stage of the disease (p = 0.02). No correlation was shown between CD74 and sex, mutational status IgVH and time to first treatment.
authors.affiliation: Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Pasteur 4 Str, 50-367 Wroclaw, Poland. aleksandra.butrym@gmail.com
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Butrym
authors.forename: Miroslaw
authors.initials: M
authors.lastname: Majewski
authors.forename: Justyna
authors.initials: J
authors.lastname: Dzietczenia
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Kuliczkowski
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Mazur
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000944:Antigens, Differentiation, B-Lymphocyte / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism; D006801:Humans; D053208:Kaplan-Meier Estimate; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D017455:Receptors, IgE / Q000097:blood / Q000378:metabolism; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism
chemical_list: D000944:Antigens, Differentiation, B-Lymphocyte; D000949:Histocompatibility Antigens Class II; D017455:Receptors, IgE; C045084:invariant chain; D002097:C-Reactive Protein; D051746:ZAP-70 Protein-Tyrosine Kinase; C497261:ZAP70 protein, human