title: CCRL2, a fringe member of the atypical chemoattractant receptor family.
abstract: The term atypical chemoattractant receptors is generally used to refer to a subset of G-protein-coupled receptors devoid of chemotactic activity and characterized by the ability to scavenge chemotactic factors from the inflammatory milieu. However, emerging evidence suggests that this class of receptors is heterogeneous in function. In this Viewpoint, we discuss the properties of CCRL2, a molecule devoid of ligand scavenging functions and suggested to regulate leukocyte recruitment by alternative mechanisms.
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Del Prete
authors.forename: Raffaella
authors.initials: R
authors.lastname: Bonecchi
authors.forename: Annunciata
authors.initials: A
authors.lastname: Vecchi
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.forename: Silvano
authors.initials: S
authors.lastname: Sozzani
mesh_terms: D000818:Animals; D060833:Cellular Microenvironment; D002630:Chemotactic Factors / Q000276:immunology*; D002633:Chemotaxis; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology*; D011485:Protein Binding; D054388:Receptors, CCR / Q000276:immunology / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000276:immunology*
chemical_list: C487531:CCRL2 protein, human; D002630:Chemotactic Factors; D054388:Receptors, CCR; D043562:Receptors, G-Protein-Coupled