title: In vivo anticancer activity of vanillin semicarbazone.
abstract: OBJECTIVE
  To evaluate the anticancer activity of vanillin semicarbazone (VSC) against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice.
  
  
  METHODS
  The compound VSC at three doses (5, 7.5 and 10 mg/kg i.p.) was administered into the intraperitoneal cavity of the EAC inoculated mice to observe its efficiency by studying the cell growth inhibition, reduction of tumour weight, enhancement of survival time as well as the changes in depleted hematological parameters. All such parameters were also studied with a known standard drug bleomycin at the dose of 0.3 mg/kg (i.p.).
  
  
  RESULTS
  Among the doses studied, 10 mg/kg (i.p.) was found to be quite comparable in potency to that of bleomycin at the dose of 0.3 mg/kg (i.p.). The host toxic effects of VSC was found to be negligible.
  
  
  CONCLUSIONS
  It can be concluded that VSC can therefore be considered as potent anticancer agent.
authors.affiliation: Department of Applied Chemistry and Chemical Engineering, University of Rajshahi.
authors.forename: Shaikh M Mohsin
authors.initials: SM
authors.lastname: Ali
authors.forename: M Abul Kalam
authors.initials: MA
authors.lastname: Azad
authors.forename: Mele
authors.initials: M
authors.lastname: Jesmin
authors.forename: Shamim
authors.initials: S
authors.lastname: Ahsan
authors.forename: M Mijanur
authors.initials: MM
authors.lastname: Rahman
authors.forename: Jahan Ara
authors.initials: JA
authors.lastname: Khanam
authors.forename: M Nazrul
authors.initials: MN
authors.lastname: Islam
authors.forename: Sha M Shahan
authors.initials: SM
authors.lastname: Shahriar
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D001547:Benzaldehydes / Q000008:administration & dosage* / Q000737:chemistry; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000473:pathology; D004195:Disease Models, Animal; D006403:Hematologic Tests; D007274:Injections, Intraperitoneal; D051379:Mice; D012664:Semicarbazones / Q000008:administration & dosage* / Q000737:chemistry; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D001547:Benzaldehydes; D012664:Semicarbazones; C100058:vanillin
keywords: Anticancer activity; Ehrlich ascites carcinoma; Schiff base