title: Shared mechanisms of alcohol and other drugs.
abstract: Identifying the changes that occur in the brain as a result of alcohol and other drug (AOD) use is important to understanding the development of AOD addiction. The nerve cell signaling chemical (i.e., neurotransmitter) γ-aminobutync acid (GABA) plays an important role in the brain chemistry of addiction. Most drugs interact with binding molecules (i.e., receptors) for specific neurotransmitters and either block or facilitate binding at these receptors. Thus, cannabis and opiates act via receptors intended for internally derived (i.e., endogenous) cannabinoid and opiate substances. In contrast, alcohol does not appear to activate specific receptors. However, alcohol influences the activity of many transmitter systems including GABA and endogenous opioids and cannabinoids.
authors.affiliation: Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California.
authors.forename: Maureen T
authors.initials: MT
authors.lastname: Cruz
authors.forename: Michal
authors.initials: M
authors.lastname: Bajo
authors.forename: Paul
authors.initials: P
authors.lastname: Schweitzer
authors.forename: Marisa
authors.initials: M
authors.lastname: Roberto
mesh_terms: D000428:Alcohol Drinking / Q000378:metabolism* / Q000473:pathology / Q000523:psychology; D000437:Alcoholism / Q000175:diagnosis / Q000378:metabolism* / Q000523:psychology; D000701:Analgesics, Opioid / Q000378:metabolism; D000818:Animals; D002186:Cannabinoids / Q000378:metabolism; D006801:Humans; D015398:Signal Transduction / Q000502:physiology; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000378:metabolism / Q000523:psychology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000701:Analgesics, Opioid; D002186:Cannabinoids; D005680:gamma-Aminobutyric Acid