title: A machine-assisted flow synthesis of SR48692: a probe for the investigation of neurotensin receptor-1.
abstract: Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1), a neurotensin receptor-1 antagonist, with its machine-assisted flow chemistry alternative. By using these enabling tools, combined with solid-supported reagents and scavengers, many process advantages were observed. Care, however, must be taken not to convert these techniques into expensive solutions to problems that do not exist.
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
authors.forename: Claudio
authors.initials: C
authors.lastname: Battilocchio
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Deadman
authors.forename: Nikzad
authors.initials: N
authors.lastname: Nikbin
authors.forename: Matthew O
authors.initials: MO
authors.lastname: Kitching
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018028:Receptors, Neurotensin / Q000037:antagonists & inhibitors*
chemical_list: D011720:Pyrazoles; D011804:Quinolines; D018028:Receptors, Neurotensin; C079087:SR 48692