title: Xpert MTB/RIF testing of stool samples for the diagnosis of pulmonary tuberculosis in children.
abstract: In a pilot accuracy study, stool Xpert testing from 115 children with suspected pulmonary tuberculosis (PTB) detected 8/17 (47%) culture-confirmed tuberculosis cases, including 4/5 (80%) HIV-infected and 4/12 (33%) HIV-uninfected children. Sputum Xpert detected 11/17 (65%) cases. Stool holds promise for PTB diagnosis in HIV-infected children.
authors.affiliation: Division of Medical Microbiology and Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, and National Health Laboratory Service of South Africa, South Africa. mark.nicol@uct.ac.za
authors.forename: Mark P
authors.initials: MP
authors.lastname: Nicol
authors.forename: Karalene
authors.initials: K
authors.lastname: Spiers
authors.forename: Lesley
authors.initials: L
authors.lastname: Workman
authors.forename: Washiefa
authors.initials: W
authors.lastname: Isaacs
authors.forename: Jacinta
authors.initials: J
authors.lastname: Munro
authors.forename: Faye
authors.initials: F
authors.lastname: Black
authors.forename: Widaad
authors.initials: W
authors.lastname: Zemanay
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Zar
mesh_terms: D000293:Adolescent; D001431:Bacteriological Techniques / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D010865:Pilot Projects; D011446:Prospective Studies; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis*
keywords: Xpert; children; diagnosis; stool; tuberculosis