title: [A case-control study on the relationship between organochlorine and female breast cancer].
abstract: OBJECTIVE
  To describe the serum organochlorines residues and explore the relationship between organochlorines exposure and the female breast cancer in Ningxia.
  
  
  METHODS
  1:1 matched case-control study based on 92 new diagnostic breast cancer patients and 92 patients without tumors from Ningxia medical university general hospital was designed. The risk factors of breast cancer were investigated by a questionnaire. GC-ECD was used to measure the serum level of organochlorines residues. The adjusted odds rations (OR) of organochlorines residues to breast cancer were evaluated by conditional Logistic regression model.
  
  
  RESULTS
  15 organochlorines residues could be detected in serum of cases and controls. The detecting rates of beta-HCH, delta-HCH, p,p'-DDE, PCB28 and PCB52 were higher than 90%. There were significant differences of serum level of beta-HCH, p,p'-DDE and PCB52 between cases and controls (P < 0.05). After adjusting confounding factors, serum beta-HCH, p,p'-DDE and PCB52 level were positively related to the risk of breast cancer (adjusted OR > 2, P < 0.05).
  
  
  CONCLUSIONS
  Organochlorines resides, including DDT, HCH and PCB, may increase women's risk of getting breast cancer.
authors.affiliation: School of Public Health, Ningxia Medical University, Yinchuan 750004, China. lindersy@126.com
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Lan
authors.initials: L
authors.lastname: Liu
authors.forename: Pengju
authors.initials: P
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xuejie
authors.initials: X
authors.lastname: Wu
authors.forename: Wensi
authors.initials: W
authors.lastname: Ni
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood* / Q000209:etiology; D016022:Case-Control Studies; D003634:DDT / Q000097:blood; D052244:Endocrine Disruptors / Q000097:blood; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D016015:Logistic Models; D008875:Middle Aged; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D052244:Endocrine Disruptors; D006843:Hydrocarbons, Chlorinated; D003634:DDT