title: Recurrent jejunal bleeding due to angiodysplasia in a Bernard-Soulier patient.
abstract: Angiodysplasia of the gastrointestinal tract consists of ectasia of the submucosal vessels of the bowels and may lead to acute or chronic bleeding. The presence of a coagulopathy will increase the frequency and the severity of gastrointestinal bleeding, whether spontaneously or medically. In literature, few cases of Bernard-Soulier syndrome associated with gastrointestinal angiodysplasia have been reported. We hereby present a female patient known to have Bernard-Soulier syndrome presenting with persistent bleeding due to jejunal angiodysplasia, which, to our knowledge, is the eighth reported case in the medical literature. The patient responded to tranexamic acid (antifibrinolytic agent) with gradual reduction in required transfusions until cessation of bleeding.
authors.affiliation: Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: Zaher K
authors.initials: ZK
authors.lastname: Otrock
authors.forename: Jad A
authors.initials: JA
authors.lastname: Degheili
authors.forename: Hassan
authors.initials: H
authors.lastname: Sibai
authors.forename: Ziad M
authors.initials: ZM
authors.lastname: Salem
mesh_terms: D000368:Aged; D016888:Angiodysplasia / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D001606:Bernard-Soulier Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D001808:Blood Vessels / Q000187:drug effects / Q000473:pathology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006801:Humans; D007583:Jejunum / Q000187:drug effects / Q000473:pathology; D012008:Recurrence; D014148:Tranexamic Acid / Q000627:therapeutic use
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid