title: Mitochondrial dysfunction induced by honokiol.
abstract: Honokiol has shown the ability to induce the apoptosis of several different cancer cell lines. Considering that mitochondria are involved in apoptosis, the aim of the present work was to investigate the effects of honokiol on mitochondria. The effects of honokiol on the permeability of H⁺ and K⁺, membrane potential, membrane fluidity, respiration and swelling of mitochondria isolated from the rat liver were assessed. The results show that honokiol can significantly induce mitochondrial swelling, decrease membrane potential and affect the respiration of mitochondria. Meanwhile, honokiol does not have a direct effect on the mitochondrial permeability transition pore.
authors.affiliation: Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Education of China, School of Chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004, People's Republic of China.
authors.forename: Jia-Xin
authors.initials: JX
authors.lastname: Dong
authors.forename: Guang-Yuan
authors.initials: GY
authors.lastname: Zhao
authors.forename: Qiu-Li-Yang
authors.initials: QL
authors.lastname: Yu
authors.forename: Ran
authors.initials: R
authors.lastname: Li
authors.forename: Lian
authors.initials: L
authors.lastname: Yuan
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000493:pharmacokinetics / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000493:pharmacokinetics / Q000494:pharmacology*; D045744:Cell Line, Tumor; D017705:Lignans / Q000493:pharmacokinetics / Q000494:pharmacology*; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000378:metabolism* / Q000473:pathology; D051336:Mitochondrial Membranes / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D010539:Permeability / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D017705:Lignans; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols