title: Primary central nervous system lymphoma: a clinicopathological and cytomorpholgical study from a tertiary care centre in Chennai, India.
abstract: BACKGROUND
  The aim of this study was to analyze the clinicopathological and immunohistochemical features of primary central nervous system lymphoma (PCNSL) cases occurring in Indian patients and also study the utility of the crush smear preparation in intraoperative diagnosis.
  
  
  METHODS
  The immune status, clinical, radiological details, immunohistochemical profile, histopathological findings and cytological features in smear preparation of 32 cases of PCNSL were analyzed. Patients with systemic NHL and skull-base lymphomas were excluded.
  
  
  RESULTS
  The mean age of our patients was 52 years with a male: female ratio 1:1. A periventricular location was found in 62.5% of patients. None of our PCNSL cases were associated with AIDS. All cases except one were diffuse large B-cell lymphomas. Intraoperative diagnosis using crush smears allowed correct prediction in 93% of cases.
  
  
  CONCLUSIONS
  Our study shows that PCNSL is seen predominantly in immunocompetent patients in India .The age of presentation is relatively young as compared to the West. Our study also stresses the utility of crush smear preparation in establishing an intraoperative diagnosis.
authors.affiliation: Department of Pathology, PIMS, Puducherry, India. drmosesa@yahoo.com
authors.forename: M Moses
authors.initials: MM
authors.lastname: Ambroise
authors.forename: Mitra
authors.initials: M
authors.lastname: Ghosh
authors.forename: Vs
authors.initials: V
authors.lastname: Mallikarjuna
authors.forename: S
authors.initials: S
authors.lastname: Annapurneswari
authors.forename: Ann
authors.initials: A
authors.lastname: Kurian
authors.forename: Ranjani
authors.initials: R
authors.lastname: Chakravarthy
mesh_terms: D000328:Adult; D000368:Aged; D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003584:Cytological Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007194:India; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000000981:diagnostic imaging; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009420:Nervous System / Q000473:pathology; D011859:Radiography; D062606:Tertiary Care Centers