title: Diagnostic accuracy of hepatic venous pressure gradient measurement in the prediction of stage 1 compensated liver cirrhosis in patients with chronic hepatitis B.
abstract: OBJECTIVE
  Hepatic venous pressure gradient (HVPG) of 6-10 mmHg has been accepted as a hemodynamic parameter of stage 1 compensated liver cirrhosis (LC). The diagnostic accuracy of HVPG in the prediction of stage 1 compensated LC has been investigated in patients with chronic hepatitis B (CHB).
  
  
  METHODS
  A total of 219 patients with CHB who underwent HVPG and liver biopsy were enrolled. The diagnostic accuracy of two methods was compared. Risk factors associated with the diagnosis of stage 1 compensated LC on the basis of the findings of HVPG, biopsy, and both HVPG and biopsy were evaluated.
  
  
  RESULTS
  The HVPG score was correlated positively with the stage of biopsy (r=0.439). The sensitivity/specificity of HVPG for predicting stage 1 compensated LC were 78/81% in 6 mmHg, respectively. A total of 57 (26%), 28 (13%), and 20 (9%) patients were diagnosed with stage 1 compensated LC on the basis of the findings of HVPG, biopsy, and both HVPG and biopsy (P>0.05), respectively. Platelet/age (-0.77-0.01×platelet+0.03×age), albumin/platelet (5.05-1.19×albumin-0.01×platelet), and platelet (0.24-0.01×platelet) were found to be risk factors (logit model) for the diagnosis of stage 1 compensated LC on the basis of the findings of HVPG, biopsy, and both HVPG and biopsy.
  
  
  CONCLUSIONS
  HVPG showed a positive correlation with biopsy, and platelet was found to be a common risk factor for the diagnosis of stage 1 compensated LC in patients with CHB.
authors.affiliation: Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon, South Korea.
authors.forename: Ki Tae
authors.initials: KT
authors.lastname: Suk
authors.forename: Heung Cheol
authors.initials: HC
authors.lastname: Kim
authors.forename: Sook
authors.initials: S
authors.lastname: Namkung
authors.forename: Sang Hak
authors.initials: SH
authors.lastname: Han
authors.forename: Kyung Chan
authors.initials: KC
authors.lastname: Choi
authors.forename: Seung Ha
authors.initials: SH
authors.lastname: Park
authors.forename: Ho Taik
authors.initials: HT
authors.lastname: Sung
authors.forename: Chang Hoon
authors.initials: CH
authors.lastname: Kim
authors.forename: Seong Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Young Lim
authors.initials: YL
authors.lastname: Ham
authors.forename: Hee Mo
authors.initials: HM
authors.lastname: Kang
authors.forename: Dong Joon
authors.initials: DJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D006503:Hepatic Veins / Q000503:physiopathology*; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000503:physiopathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014690:Venous Pressure / Q000502:physiology