title: Injection of specific amyloid-beta oligomers (beta₁₋₄₀:beta₁₋₄₂ = 10:1) into rat medial septum impairs memory retention without inducing hippocampal apoptosis.
abstract: OBJECTIVE
  Because of the well-known neurochemical interactions between the septum and hippocampus during memory processes, we investigated the effect of amyloid-beta (A-beta) injection into the medial septum (MS) on the behavior in Wistar rats. We also assessed whether the observed effects were functional or due to apoptosis.
  
  
  METHODS
  Specific A-beta oligomers (beta1-40:beta1-42 = 10:1) were injected into MS for seven consecutive days. Behavior was assessed with the Morris water maze task.
  
  
  RESULTS
  Compared with the control group, rats that received A-beta oligomers exhibited significant memory retention impairment (P < 0·05) without apoptosis in the cornu ammonis (CA)1 and CA3 regions of the dorsal hippocampus.
  
  
  CONCLUSIONS
  These data indicate that septal injection of A-beta impairs memory retention, even in the absence of hippocampal apoptosis. This result might bring new insight to spatial memory-related disorders like Alzheimer's disease (AD).
authors.affiliation: Pamukkale University, Denizli, Turkey.
authors.forename: Mehmet Bülent
authors.initials: MB
authors.lastname: Ozdemir
authors.forename: Cagdas
authors.initials: C
authors.lastname: Erdogan
authors.forename: Katsunori
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Takuya
authors.initials: T
authors.lastname: Watanabe
authors.forename: Shin
authors.initials: S
authors.lastname: Ishikane
authors.forename: Michihiro
authors.initials: M
authors.lastname: Fujiwara
mesh_terms: D016229:Amyloid beta-Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000473:pathology; D056654:CA3 Region, Hippocampal / Q000187:drug effects / Q000473:pathology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008845:Microinjections; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects*; D020665:Septum of Brain / Q000187:drug effects*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)