title: Supramolecular filaments containing a fixed 41% paclitaxel loading.
abstract: We report here the self-assembly of a rationally designed paclitaxel drug amphiphile into well-defined supramolecular filaments that possess a fixed 41% paclitaxel loading. These filaments can exert effective cytotoxicity against a number of cell lines comparable to that of free paclitaxel.
authors.affiliation: Department of Chemical and Biomolecular Engineering, and Institute for NanoBioTechnology, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.
authors.forename: Ran
authors.initials: R
authors.lastname: Lin
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Cheetham
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Zhang
authors.forename: Yi-an
authors.initials: YA
authors.lastname: Lin
authors.forename: Honggang
authors.initials: H
authors.lastname: Cui
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry; D006801:Humans; D061986:MCF-7 Cells; D046529:Microscopy, Electron, Transmission; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D009842:Oligopeptides / Q000737:chemistry*; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry*; D016875:tau Proteins / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D009842:Oligopeptides; D016875:tau Proteins; D005978:Glutathione; D017239:Paclitaxel