title: Multi-criteria optimization for ultrasonic-assisted extraction of antioxidants from Pericarpium Citri Reticulatae using response surface methodology, an activity-based approach.
abstract: An activity-based approach to optimize the ultrasonic-assisted extraction of antioxidants from Pericarpium Citri Reticulatae (Chenpi in Chinese) was developed. Response surface optimization based on a quantitative composition-activity relationship model showed the relationships among product chemical composition, antioxidant activity of extract, and parameters of extraction process. Three parameters of ultrasonic-assisted extraction, including the ethanol/water ratio, Chenpi amount, and alkaline amount, were investigated to give optimum extraction conditions for antioxidants of Chenpi: ethanol/water 70:30 v/v, Chenpi amount of 10 g, and alkaline amount of 28 mg. The experimental antioxidant yield under the optimum conditions was found to be 196.5 mg/g Chenpi, and the antioxidant activity was 2023.8 μmol Trolox equivalents/g of the Chenpi powder. The results agreed well with the second-order polynomial regression model. This presented approach promised great application potentials in both food and pharmaceutical industries.
authors.affiliation: Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Zeng
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Haibin
authors.initials: H
authors.lastname: Qu
authors.forename: Xingchu
authors.initials: X
authors.lastname: Gong
mesh_terms: D000975:Antioxidants / Q000032:analysis / Q000302:isolation & purification*; D005591:Chemical Fractionation / Q000295:instrumentation / Q000379:methods*; D002957:Citrus / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000302:isolation & purification*; D005638:Fruit / Q000737:chemistry; D014465:Ultrasonics / Q000379:methods*
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; C557482:chenpi