title: The effect of fibrin glue on tendon healing and adhesion formation in a rabbit model of flexor tendon injury and repair.
abstract: Fibrin glue has been widely used in a variety of surgical procedures to promote haemostasis and tissue bonding. It can also be used as a cell carrier for stem cells on tendons. However, the data about the effect of fibrin glue on flexor tendon healing is very limited. The present study examined the role of fibrin glue TISSEEL® in a rabbit model of flexor tendon injury. The rabbits were killed 3 or 8 weeks after the operation. The range-of-motion of the fingers and biomechanical properties of tendons were measured and compared between the control group and TISSEEL-treated group. The findings have shown that the range-of-motion in the TISSEEL-treated group was significantly different from that of the control group at 3 weeks after the operation. However, there is no significant difference in range-of-motion at 8 weeks after the operation. Moreover, there is no significant difference in biomechanical properties between the control group and TISSEEL-treated group. The results indicate that TISSEEL may attenuate adhesion formation at the early stage of flexor tendon repair. However, there is no significant effect on biomechanical features during tendon repair. In conclusion, this study has shown that it may be safe to use TISSEEL in tissue engineering applications for tendon regeneration and healing.
authors.affiliation: Hand & Reconstructive Microsurgery, National University Hospital , Singapore.
authors.forename: Min
authors.initials: M
authors.lastname: He
authors.forename: Aaron W T
authors.initials: AW
authors.lastname: Gan
authors.forename: Aymeric Y T
authors.initials: AY
authors.lastname: Lim
authors.forename: James C H
authors.initials: JC
authors.lastname: Goh
authors.forename: James H P
authors.initials: JH
authors.lastname: Hui
authors.forename: Eng Hin
authors.initials: EH
authors.lastname: Lee
authors.forename: Alphonsus K S
authors.initials: AK
authors.lastname: Chong
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D005552:Forelimb / Q000293:injuries / Q000601:surgery; D023421:Models, Animal; D011817:Rabbits; D016059:Range of Motion, Articular; D012038:Regeneration / Q000502:physiology; D013708:Tendon Injuries / Q000601:surgery*; D013710:Tendons / Q000502:physiology / Q000601:surgery; D000267:Tissue Adhesions / Q000517:prevention & control; D014014:Tissue Adhesives / Q000008:administration & dosage*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives