title: Association between ADAM33 S2 and ST+4 polymorphisms and susceptibility to asthma: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to determine whether ADAM33 (a disintegrin and metalloproteinase domain 33) polymorphisms confer susceptibility to asthma in different populations.
  
  
  METHODS
  We performed a meta-analysis on the association between the ADAM33 S2, ST+4, F+1, S1, and V4 polymorphisms and asthma.
  
  
  RESULTS
  Thirteen studies in ten reports, which included 4942 patients and 7933 controls, were available for the meta-analysis. Meta-analysis stratified by ethnicity indicated an association between the ADAM33 S2 2 allele and asthma in Europeans (OR=0.912, 95% CI=0.851-0.977, p=0.009). Meta-analysis revealed an association between asthma and the ADAM33 ST+4 2 allele (OR=0.783, 95% CI=0.762-0.999, p=0.048). Stratification by ethnicity indicated an association between the ADAM33 ST+4 polymorphism and asthma in Asians. Stratification by age indicated an association between the ADAM33 ST+4 2 allele and asthma in adults (OR=0.863, 95% CI=0.782-0.964, p=0.008). However, no association was found between asthma and the ADAM33 F+1, S1, and V4 polymorphisms.
  
  
  CONCLUSIONS
  This meta-analysis demonstrates that the ADAM33 S2 polymorphism confers susceptibility to asthma in Europeans and the ADAM33 ST+4 polymorphism is associated with asthma in Asians and adults.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000367:Age Factors; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000235:genetics*; D016001:Confidence Intervals; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005828:Genetics, Population / Q000379:methods; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics
chemical_list: D051722:ADAM Proteins; C450441:ADAM33 protein, human