title: A comparative chemical-biological evaluation of titanium(IV) complexes with a salan or cyclopentadienyl ligand.
abstract: Titanium(IV) complexes with a salan or cyclopentadienyl ligand showed different biological behaviour concerning binding to biomolecules, cellular accumulation and intracellular distribution. Binding efficacy as well as trafficking on the cellular level are crucial parameters for their biological effects.
authors.affiliation: Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Braunschweig, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Schur
authors.forename: Cesar M
authors.initials: CM
authors.lastname: Manna
authors.forename: Anthony
authors.initials: A
authors.lastname: Deally
authors.forename: Reinhard W
authors.initials: RW
authors.lastname: Köster
authors.forename: Matthias
authors.initials: M
authors.lastname: Tacke
authors.forename: Edit Y
authors.initials: EY
authors.lastname: Tshuva
authors.forename: Ingo
authors.initials: I
authors.lastname: Ott
mesh_terms: D000418:Albumins / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000187:drug effects; D019073:HT29 Cells; D006801:Humans; D008024:Ligands; D061986:MCF-7 Cells; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*; D015027:Zebrafish
chemical_list: D000418:Albumins; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D009942:Organometallic Compounds; C518838:Titanocene Y; D004247:DNA; D014025:Titanium