title: Persufflation (gaseous oxygen perfusion) as a method of heart preservation.
abstract: Persufflation (PSF; gaseous oxygen perfusion) is an organ preservation technique with a potential for use in donor heart preservation. Improved heart preservation with PSF may improve outcomes by maintaining cardiac tissue quality in the setting of longer cold ischemia times and possibly increasing the number of donor hearts available for allotransplant. Published data suggests that PSF is able to extend the cold storage times for porcine hearts up to 14 hours without compromising viability and function, and has been shown to resuscitate porcine hearts following donation after cardiac death. This review summarizes key published work on heart PSF, including prospective implications and future directions for PSF in heart transplantation. We emphasize the potential impact of extending preservation times and expanding donor selection criteria in heart allotransplant. Additionally, the key issues that need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation are summarized and discussed.
authors.affiliation: Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Suszynski
authors.forename: Michael D
authors.initials: MD
authors.lastname: Rizzari
authors.forename: William E
authors.initials: WE
authors.lastname: Scott
authors.forename: Peter M
authors.initials: PM
authors.lastname: Eckman
authors.forename: James D
authors.initials: JD
authors.lastname: Fonger
authors.forename: Ranjit
authors.initials: R
authors.lastname: John
authors.forename: Nicolas
authors.initials: N
authors.lastname: Chronos
authors.forename: Linda A
authors.initials: LA
authors.lastname: Tempelman
authors.forename: David E R
authors.initials: DE
authors.lastname: Sutherland
authors.forename: Klearchos K
authors.initials: KK
authors.lastname: Papas
mesh_terms: D000818:Animals; D006321:Heart; D016027:Heart Transplantation; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009926:Organ Preservation / Q000266:history* / Q000379:methods*; D010100:Oxygen / Q000502:physiology / Q000627:therapeutic use; D010477:Perfusion / Q000266:history / Q000379:methods
chemical_list: D010100:Oxygen