title: Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.
abstract: Five novel tigliane-type diterpenes, stelleracins A-E (3-7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from the roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds 3-5 showed potent anti-HIV activity (EC90 0.00056-0.0068 μM) and relatively low or no cytotoxicity (IC50 4.4-17.2 μM). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Asada
authors.forename: Aya
authors.initials: A
authors.lastname: Sukemori
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Kuber J
authors.initials: KJ
authors.lastname: Malla
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Xinzhu
authors.initials: X
authors.lastname: Kuang
authors.forename: Kazuo
authors.initials: K
authors.lastname: Koike
authors.forename: Chin-Ho
authors.initials: CH
authors.lastname: Chen
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Akiyama
authors.forename: Keduo
authors.initials: K
authors.lastname: Qian
authors.forename: Kyoko
authors.initials: K
authors.lastname: Nakagawa-Goto
authors.forename: Susan L
authors.initials: SL
authors.lastname: Morris-Natschke
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D009390:Nepal; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D004224:Diterpenes; D044950:Flavanones; C028610:flavanone