title: Simultaneous ingestion of fructose and fat exacerbates postprandial exogenous lipidemia in young healthy Japanese women.
abstract: OBJECTIVE
  To investigate the acute effects of the simultaneous ingestion of fructose and fat on postprandial lipoprotein metabolism in healthy young women.
  
  
  METHODS
  Nine young healthy Japanese women with a normal weight (body mass index: 18.5≤-< 25 kg/m(2)), a normal ovarian cycle and an apolipoprotein E 3/3 phenotype were enrolled as participants and studied on four occasions. At each session, the subjects ingested one of four beverages containing either glucose or fructose (0.5 g/kg body weight each) with or without OFTT cream (1 g/kg, 0.35 g/ kg as fat) in a randomized crossover design. Blood samples were collected at baseline and at 0.5, 1, 2, 4 and 6 hours after ingestion.
  
  
  RESULTS
  The ingestion of fructose combined with fat led to significantly higher rises in the serum triglyceride (TG), remnant-like particle (RLP)-TG, remnant lipoprotein-cholesterol (RemL-C) and apolipoprotein B-48 (apoB48) concentrations with delayed peaks compared with that observed following ingestion of the other three types of beverages. The incremental area under the curve (ΔAUC)-TG and ΔAUC-apoB48 were larger than those observed for the ingestion of fat only. The serum RLP-TG and apoB48 concentrations returned to the fasting levels (0 hours) at the end of the test (6 hours) following the ingestion of fat only; however, these concentrations did not return to the fasting levels following the intake of fructose combined with fat.
  
  
  CONCLUSIONS
  These findings suggest a delay in the clearance of intestinal TG-rich lipoproteins, namely chylomicron and its remnant, following the ingestion of fructose combined with fat. The simultaneous ingestion of fructose and fat markedly enhances postprandial exogenous lipidemia in young healthy Japanese women.
authors.affiliation: Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya 464-8662, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Saito
authors.forename: Mieko
authors.initials: M
authors.lastname: Kagaya
authors.forename: Maiko
authors.initials: M
authors.lastname: Suzuki
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yoshida
authors.forename: Michitaka
authors.initials: M
authors.lastname: Naito
mesh_terms: D053283:Apolipoprotein B-48 / Q000097:blood; D044466:Asian People; D002784:Cholesterol / Q000097:blood; D053298:Chylomicron Remnants / Q000097:blood; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005632:Fructose / Q000008:administration & dosage* / Q000009:adverse effects; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000209:etiology*; D007328:Insulin / Q000097:blood; D007564:Japan; D019344:Lactic Acid / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D019518:Postprandial Period / Q000502:physiology; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D053283:Apolipoprotein B-48; D053298:Chylomicron Remnants; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides; C112017:remnant-like particle cholesterol; D005632:Fructose; D019344:Lactic Acid; D002784:Cholesterol; D005947:Glucose