title: Usefulness of magnetocardiography to detect coronary artery disease and cardiac allograft vasculopathy.
abstract: BACKGROUND
  Electrophysiological information as well as anatomic information are important for the detection of coronary artery lesions. The aim of this study was to assess the efficacy of resting magnetocardiography (MCG) in stable coronary artery disease (CAD) and cardiac allograft vasculopathy (CAV).
  
  
  RESULTS
  MCG and coronary angiography were performed within 1 month in 75 patients with suspected CAD and in 26 subjects after orthotopic heart transplantation (OHT). Plaque volumes were additionally measured on intravascular ultrasound in OHT recipients. The spatially distributed QT(c) interval maps were constructed with 64-channel MCG. A T-wave propagation map and QT(c) heterogeneity index including QT(c) dispersion and smoothness index of QT(c) (SI-QT(c)) were derived for ischemia detection and localization. CAD patients had higher QT(c) dispersion and SI-QT(c). Receiver operating characteristic curve analysis identified SI-QT(c) ≥9 ms, QT(c) dispersion ≥79 ms as the optimal cut-off for detecting CAD (diagnostic accuracy, 0.7953, 0.7819), better than T-wave propagation (0.6594, P<0.05). There was no significant difference of QT(c) dispersion between CAD and OHT subjects. In OHT recipients, QT(c) dispersion positively correlated with plaque volume, and SI-QT(c) progressively increased after transplantation. Using T-wave propagation mapping, regionally increased dispersion could be demonstrated in CAD patients, but increased dispersion was noted in fewer OHT recipients.
  
  
  CONCLUSIONS
  MCG is clinically feasible as a non-invasive tool for diagnosis of CAD, and could be used as a surrogate marker of CAV.
authors.affiliation: Cardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
authors.forename: Yen-Wen
authors.initials: YW
authors.lastname: Wu
authors.forename: Chii-Ming
authors.initials: CM
authors.lastname: Lee
authors.forename: Yen-Bin
authors.initials: YB
authors.lastname: Liu
authors.forename: Shoei-Shen
authors.initials: SS
authors.lastname: Wang
authors.forename: Hui-Chun
authors.initials: HC
authors.lastname: Huang
authors.forename: Wei-Kung
authors.initials: WK
authors.lastname: Tseng
authors.forename: Hsiang-Yiang
authors.initials: HY
authors.lastname: Jui
authors.forename: Shan-Ying
authors.initials: SY
authors.lastname: Wang
authors.forename: Herng-Er
authors.initials: HE
authors.lastname: Horng
authors.forename: Hong-Chang
authors.initials: HC
authors.lastname: Yang
authors.forename: Chau-Chung
authors.initials: CC
authors.lastname: Wu
mesh_terms: D000368:Aged; D064591:Allografts; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003331:Coronary Vessels / Q000503:physiopathology* / Q000648:ultrastructure*; D004452:Echocardiography; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D053798:Magnetocardiography; D008297:Male; D008875:Middle Aged