title: Prostate cancer susceptibility genes on 8p21-23 in a Dutch population.
abstract: BACKGROUND
  Prostate cancer is the most commonly diagnosed cancer in men in Europe and the United States. Numerous studies have indicated genetics to have a major role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have detected an association between prostate cancer and chromosome 8p21-23. In this study, we analysed eight microsatellite (MS) markers in that region in order to confirm previous results and narrow down the location of candidate prostate cancer genes.
  
  
  METHODS
  292 cases and 278 controls were selected from the Netherlands Cohort Study (NLCS). The following MSs were used in the analyses: D8S136, D8S1734, D8S1742, D8S261, D8S262, D8S351, D8S511 and D8S520. Associations were evaluated using a χ(2) test and logistic regression. We checked for any effects on the association by tumour stage.
  
  
  RESULTS
  Associations that were found confirmed previous research that pointed to the 8p21-23 region. Two MSs: D8S136 (odds ratio (OR), 0.69; P=4.00 × 10(-28)), and D8S520 (OR, 0.80; P=3.37 × 10(-11)), were consistently and strongly related with prostate cancer. Genotype analysis showed an additive effect for D8S136 (P-trend=6.22 × 10(-03)) and D8S520 (P-trend=2.62 × 10(-22)), suggesting an increased risk for people with a short number of repeats on both alleles at those markers.
  
  
  CONCLUSIONS
  This study provides strong evidence that the 8p21-23 region is likely to harbour prostate cancer genes.
authors.affiliation: Unit of Urologic and Genetic Epidemiology, Department of Public Health, Epidemiology and Biostatistics, School of Health and Population Sciences, University of Birmingham, Birmingham, UK.
authors.forename: M P
authors.initials: MP
authors.lastname: Zeegers
authors.forename: D
authors.initials: D
authors.lastname: Nekeman
authors.forename: H S
authors.initials: HS
authors.lastname: Khan
authors.forename: B A C
authors.initials: BA
authors.lastname: van Dijk
authors.forename: R A
authors.initials: RA
authors.lastname: Goldbohm
authors.forename: J
authors.initials: J
authors.lastname: Schalken
authors.forename: S
authors.initials: S
authors.lastname: Shajahan
authors.forename: A
authors.initials: A
authors.lastname: Pearlman
authors.forename: C
authors.initials: C
authors.lastname: Oddoux
authors.forename: P A
authors.initials: PA
authors.lastname: van den Brandt
authors.forename: L J
authors.initials: LJ
authors.lastname: Schouten
authors.forename: H
authors.initials: H
authors.lastname: Ostrer
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8; D015331:Cohort Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009426:Netherlands; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics*