title: Molecular characterization of blaNDM-1 in a sequence type 235 Pseudomonas aeruginosa isolate from France.
abstract: An NDM-1 carbapenemase-producing Pseudomonas aeruginosa isolate was recovered from a patient hospitalized in France after a previous hospitalization in Serbia. Genetic studies revealed that the blaNDM-1 gene was surrounded by insertion sequence ISAba125 and a truncated bleomycin resistance gene. This blaNDM-1 region was a part of the variable region of a new complex class 1 integron bearing IS common region 1 (ISCR1). The presence of ISPa7 upstream of this integron suggests insertion in a chromosomally located Tn402-like structure.
authors.affiliation: Service de Microbiologie-Hygiène, Hôpital d'Instruction des Armées Bégin, Saint-Mandé, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Janvier
authors.forename: Katy
authors.initials: K
authors.lastname: Jeannot
authors.forename: Sophie
authors.initials: S
authors.lastname: Tessé
authors.forename: Marjorie
authors.initials: M
authors.lastname: Robert-Nicoud
authors.forename: Hervé
authors.initials: H
authors.lastname: Delacour
authors.forename: Christophe
authors.initials: C
authors.lastname: Rapp
authors.forename: Audrey
authors.initials: A
authors.lastname: Mérens
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D015780:Carbapenems / Q000494:pharmacology; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000235:genetics; D005260:Female; D005602:France; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008969:Molecular Sequence Data; D011552:Pseudomonas Infections; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D011704:Pyelonephritis / Q000188:drug therapy / Q000382:microbiology*; D017422:Sequence Analysis, DNA; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1; C063912:carbapenemase