title: Clinical relevance of cancer genome sequencing.
abstract: The arrival of both high-throughput and bench-top next-generation sequencing technologies and sequence enrichment methods has revolutionized our approach to dissecting the genetic basis of cancer. These technologies have been almost invariably employed in whole-genome sequencing (WGS) and whole-exome sequencing (WES) studies. Both WGS and WES approaches have been widely applied to interrogate the somatic mutational landscape of sporadic cancers and identify novel germline mutations underlying familial cancer syndromes. The clinical implications of cancer genome sequencing have become increasingly clear, for example in diagnostics. In this editorial, we present these advances in the context of research discovery and discuss both the clinical relevance of cancer genome sequencing and the challenges associated with the adoption of these genomic technologies in a clinical setting.
authors.forename: Chee Seng
authors.initials: CS
authors.lastname: Ku
authors.forename: David N
authors.initials: DN
authors.lastname: Cooper
authors.forename: Dimitrios H
authors.initials: DH
authors.lastname: Roukos
mesh_terms: D004252:DNA Mutational Analysis; D030541:Databases, Genetic; D059472:Exome; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D007391:International Cooperation; D009154:Mutation; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*
keywords: Cancer; Diagnostics; Exome; Familial cancer syndrome; Next-generation sequencing; Somatic mutation