title: Effect of B-value in revealing postinfarct myocardial microstructural remodeling using MR diffusion tensor imaging.
abstract: Nonmonoexponential diffusion behavior has been previously reported to exist in some biological tissues, making quantification of diffusion tensor imaging (DTI) indices dependent on diffusion sensitivity of b-value. This study aims to investigate the effect of b-value in revealing postinfarct myocardial microstructural remodeling in ex vivo hearts. DTI scans were performed on heart samples 1, 3, 5, and 7 days after infarction induction as well as intact controls with b-values of 500 to 2500s/mm(2). DTI indices, including fractional anisotropy (FA), and mean and directional diffusivities, were measured in infarct, adjacent and remote regions with zero and each non-zero b-values respectively using conventional DTI analysis. Experimental results showed that these DTI indices decreased gradually with b-values in all regions and groups. Optimal b-values were found to vary with targeted DTI indices, and could strengthen DTI ability in revealing myocardium degradation with using conventional DTI approach. Specifically, FA showed the most sensitive detection of fiber integrity degradation at moderate b-values (≈1500 to 2000s/mm(2)), and the greatest ability of mean and directional diffusivities in monitoring diffusivity alteration occurred at relatively small b-values (≤1500s/mm(2)) during the necrotic and fibrotic phases. These findings may provide useful information for DTI protocol parameter optimization in assessing heart microstructures at other pathological or in vivo states in the future.
authors.affiliation: Paul C. Lauterbur Research Centre for Biomedical Imaging, Shenzhen Key Laboratory for MRI, Shenzhen Institutes of Advanced Technology, Shenzhen, Guangdong, China. yin.wu@siat.ac.cn
authors.forename: Yin
authors.initials: Y
authors.lastname: Wu
authors.forename: Chao
authors.initials: C
authors.lastname: Zou
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Weiqi
authors.initials: W
authors.lastname: Liao
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: David A
authors.initials: DA
authors.lastname: Porter
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Ed X
authors.initials: EX
authors.lastname: Wu
mesh_terms: D000818:Animals; D056324:Diffusion Tensor Imaging / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009203:Myocardial Infarction / Q000150:complications* / Q000473:pathology*; D011817:Rabbits; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000209:etiology* / Q000473:pathology*; D020257:Ventricular Remodeling