title: Non-destructive multibiomarker approach in European quail (Coturnix coturnix coturnix) exposed to the herbicide atrazine.
abstract: The effect of orally administered atrazine (25 or 100 mg/kg on days 0, 5, and 10 of the experiment) was studied in European quail (Coturnix coturnix coturnix) on four non-destructive biomarkers: fecal porphyrins, blood glutathione-S-transferase, glutathione reductase, reduced glutathione, and malondialdehyde (MDA). Uroporphyrin I (UPI) and coproporphyrins I and III (CPIII) were the main porphyrins detected in feces. The lowest dose of ATZ caused a significant (P < 0.05) increase in UPI and CPIII at day 5, and the highest dose of ATZ caused an induction of CPI and a significant (P < 0.05) decrease in MDA levels at day 30.
authors.affiliation: Toxicology Unit, Veterinary School (UEx), 10071 Cáceres, Spain. delacasa@unex.es
authors.forename: I
authors.initials: I
authors.lastname: de la Casa-Resino
authors.forename: D
authors.initials: D
authors.lastname: Hernández-Moreno
authors.forename: J M
authors.initials: JM
authors.lastname: Navas
authors.forename: F
authors.initials: F
authors.lastname: Soler
authors.forename: M
authors.initials: M
authors.lastname: Pérez-López
mesh_terms: D000818:Animals; D001280:Atrazine / Q000633:toxicity*; D015415:Biomarkers / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003370:Coturnix / Q000378:metabolism*; D004781:Environmental Exposure; D005243:Feces / Q000737:chemistry; D005260:Female; D005470:Fluorometry; D005978:Glutathione / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D006540:Herbicides / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D011166:Porphyrins / Q000378:metabolism; D013053:Spectrophotometry
chemical_list: D015415:Biomarkers; D006540:Herbicides; D011166:Porphyrins; D008315:Malondialdehyde; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione; D001280:Atrazine