title: Directed amination of non-acidic arene C-H bonds by a copper-silver catalytic system.
abstract: Amine meets arene: A method for direct amination of β-C(sp(2))-H bonds of benzoic acid derivatives and γ-C(sp(2))-H bonds of benzylamine derivatives has been developed. The reaction is catalyzed by Cu(OAc)2 and a Ag2CO3 cocatalyst, and shows high generality and functional-group tolerance, as well as providing a straightforward means for the preparation of ortho-aminobenzoic acid derivatives.
authors.affiliation: Department of Chemistry, University of Houston, Houston, TX 77204-5003, USA.
authors.forename: Ly Dieu
authors.initials: LD
authors.lastname: Tran
authors.forename: James
authors.initials: J
authors.lastname: Roane
authors.forename: Olafs
authors.initials: O
authors.lastname: Daugulis