title: Anti-oxidant vitamin E prevents accumulation of imatinib-resistant BCR-ABL1 kinase mutations in CML-CP xenografts in NSG mice.
authors.affiliation: Department of Microbiology and Immunology, School of Medicine, Temple University, Philadelphia, PA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Nieborowska-Skorska
authors.forename: G
authors.initials: G
authors.lastname: Hoser
authors.forename: A
authors.initials: A
authors.lastname: Hochhaus
authors.forename: T
authors.initials: T
authors.lastname: Stoklosa
authors.forename: T
authors.initials: T
authors.lastname: Skorski
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D000975:Antioxidants / Q000627:therapeutic use*; D001549:Benzamides / Q000009:adverse effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D000068877:Imatinib Mesylate; D053631:Interleukin Receptor Common gamma Subunit / Q000502:physiology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics / Q000517:prevention & control*; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D009154:Mutation / Q000235:genetics*; D010879:Piperazines / Q000009:adverse effects*; D011743:Pyrimidines / Q000009:adverse effects*; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; C581634:BCR-ABL1 fusion protein, human; D001549:Benzamides; C507942:Il2rg protein, mouse; D053631:Interleukin Receptor Common gamma Subunit; D010879:Piperazines; D011743:Pyrimidines; D014810:Vitamin E; D000068877:Imatinib Mesylate; D016044:Fusion Proteins, bcr-abl