title: Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography.
abstract: BACKGROUND
  The association between lipoprotein levels and coronary plaque composition is not well understood.
  
  
  OBJECTIVE
  The aim of this prospective international multicenter study of statin-naive individuals was to evaluate the association of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC) to coronary plaque composition by coronary computed tomographic angiography (CTA).
  
  
  METHODS
  We studied 4575 individuals without known coronary artery disease not taking statin medications who underwent coronary CTA. Comparisons were made between those with high versus low LDL, HDL, TC, and non-HDL. We assessed the relationship of lipoproteins and plaques of specific composition (noncalcified [NCP], partially calcified [PCP], or calcified [CP] plaque).
  
  
  RESULTS
  Mean age was 57 ± 11 years (55% men). In univariable analyses, high LDL, low HDL, high TC, and high non-HDL were each associated with increased prevalence of NCPs, PCPs, and CPs (P < 0.05 for all). In multivariable analyses, high non-HDL was associated with the presence of NCP (odds ratio, 1.47; 95% CI, 1.22-1.78: P < 0.001). In the further subanalysis, a weak relationship between the highest group of non HDL (≥190 mg/dL) and the presence of CP was also noted (odds ratio, 1.33; 95% CI, 1.01-1.76; P = 0.04). Further, high non-HDL was associated with increasing numbers of segments with NCP (β coefficient, 0.043; 95% CI, 0.021-0.065; P < 0.001) but not segments with PCP or CP.
  
  
  CONCLUSIONS
  NCP presence and extent are associated with high non-HDL. These results suggest a relationship between lipid profile and plaque composition.
authors.affiliation: Cedars-Sinai Heart Institute and Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Ryo
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authors.forename: Heidi
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authors.lastname: Gransar
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Berman
authors.forename: Victor Y
authors.initials: VY
authors.lastname: Cheng
authors.forename: Fay Y
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authors.lastname: Lin
authors.forename: Stephan
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authors.lastname: Achenbach
authors.forename: Mouaz
authors.initials: M
authors.lastname: Al-Mallah
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Budoff
authors.forename: Filippo
authors.initials: F
authors.lastname: Cademartiri
authors.forename: Tracy Q
authors.initials: TQ
authors.lastname: Callister
authors.forename: Hyuk-jae
authors.initials: HJ
authors.lastname: Chang
authors.forename: Kavitha
authors.initials: K
authors.lastname: Chinnaiyan
authors.forename: Benjamin J W
authors.initials: BJ
authors.lastname: Chow
authors.forename: Augustin
authors.initials: A
authors.lastname: Delago
authors.forename: Martin
authors.initials: M
authors.lastname: Hadamitzky
authors.forename: Joerg
authors.initials: J
authors.lastname: Hausleiter
authors.forename: Philipp
authors.initials: P
authors.lastname: Kaufmann
authors.forename: Erica
authors.initials: E
authors.lastname: Maffei
authors.forename: Gilbert
authors.initials: G
authors.lastname: Raff
authors.forename: Leslee J
authors.initials: LJ
authors.lastname: Shaw
authors.forename: Todd C
authors.initials: TC
authors.lastname: Villines
authors.forename: Allison
authors.initials: A
authors.lastname: Dunning
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Cury
authors.forename: Gudrun
authors.initials: G
authors.lastname: Feuchtner
authors.forename: Yong-Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Jonathon
authors.initials: J
authors.lastname: Leipsic
authors.forename: James K
authors.initials: JK
authors.lastname: Min
mesh_terms: D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D017023:Coronary Angiography / Q000706:statistics & numerical data*; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D038622:Internationality; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*
chemical_list: D015415:Biomarkers; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002784:Cholesterol