title: Lower than normal mean platelet volume is associated with reduced extent of coronary artery disease.
abstract: BACKGROUND
  Extent of atherosclerotic coronary artery disease in patients with stable angina has important prognostic and therapeutic implications. In current models of plaque evolution, thrombocytes play an important role in plaque growth. Mean platelet volume is a readily obtainable marker that was shown to correlate with platelet aggregability in vitro and increased values were demonstrated after acute vascular events.
  
  
  OBJECTIVE
  In this study, we investigated the relationship of mean platelet volume and angiographic extent of coronary artery disease in patients with stable angina.
  
  
  METHODS
  Past medical records, complete blood count and angiographic data of 267 eligible stable angina patients were reviewed. Angiographic extent of coronary artery disease was evaluated form angiographic data using Gensini score by an expert in invasive cardiology. Mean platelet volume values were obtained from complete blood counts that obtained one day before angiography. Patients were grouped as those within (n = 176) and lower than (n = 62) population-based range for mean platelet volume. Comparison between groups and correlation analysis was performed.
  
  
  RESULTS
  There were no linear correlation between total Gensini score and mean platelet volume (p = 0.29), while total thrombocyte count was inversely correlated with mean platelet volume (p < 0.001; r = 0.41). Patients with lower than normal mean platelet volume had significantly lower Gensini score (36.73 ± 32.5 vs. 45.63 ± 32.63; p = 0.023) and three-vessel disease (18% vs. 36%; p = 0.007) compared with those mean platelet volume values within population-based ranges.
  
  
  CONCLUSIONS
  Our findings show no linear relationship exists between mean platelet volume and extent of coronary artery disease, while patients with lower than normal mean platelet volume had reduced extent of coronary artery disease.
authors.affiliation: School of Medicine, Kafkas University, Kars, Turkey. tsguvenc@gmail.com
authors.forename: Tolga Sinan
authors.initials: TS
authors.lastname: Güvenç
authors.forename: Hakan
authors.initials: H
authors.lastname: Hasdemir
authors.forename: Hatice Betül
authors.initials: HB
authors.lastname: Erer
authors.forename: Erkan
authors.initials: E
authors.lastname: Ilhan
authors.forename: Kazım Serhan
authors.initials: KS
authors.lastname: Ozcan
authors.forename: Ali Nazmi
authors.initials: AN
authors.lastname: Calık
authors.forename: Rengin
authors.initials: R
authors.lastname: Cetin
authors.forename: Mehmet
authors.initials: M
authors.lastname: Eren
mesh_terms: D060050:Angina, Stable / Q000097:blood* / Q000000981:diagnostic imaging; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000473:pathology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers