title: [Preparation and application on compound excipient of sodium stearyl fumarate and plasdone S-630].
abstract: The compound excipient containing sodium stearyl fumarate and plasdone S-630 was prepared by applying spray drying method. The basic physical properties of compound excipient were studied by solubility test, scanning electron microscope, differential scanning calorimeter, X-ray diffraction and Fourier transform infra-red spectroscopy. The effect of compound excipient on moisture absorption and ferulic acid in vitro dissolution of spray drying power of angelica were investigated. The results showed that the chemical constituents of compound excipient did not change before and after spray drying. The water soluble compound excipient can improve significantly moisture absorption and has application prospect.
authors.affiliation: Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
authors.forename: Yan-Rong
authors.initials: YR
authors.lastname: Jiang
authors.forename: Zhen-Hai
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Jia
mesh_terms: D000085:Acetates / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003373:Coumaric Acids / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry; D005650:Fumarates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011205:Povidone / Q000031:analogs & derivatives* / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D017155:Wettability; D014961:X-Ray Diffraction
chemical_list: D000085:Acetates; D003373:Coumaric Acids; D005079:Excipients; D005650:Fumarates; C525248:copolyvidonum Plasdone S-630; C519579:sodium stearyl fumarate; C004999:ferulic acid; D011205:Povidone