title: Cerebellar TMS in treatment of a patient with cerebellar ataxia: evidence from clinical, biomechanics and neurophysiological assessments.
abstract: We describe a patient with a probable diagnosis of idiopathic late-onset cerebellar atrophy who shows improvement of limb coordination, speech, and gait following 21 days of transcranial magnetic stimulation (TMS) applied to scalp regions presumably corresponding to the cerebellum. This case study provides, for the first time, a quantitative assessment of gait improvement in response to TMS therapy in ataxia, as well as neurophysiological evidence in support of modification of cerebellar-cortical interaction that may underlie some of the improvements.
authors.affiliation: Beth Israel Deaconess Medical Center, 330 Brookline Ave, Kirstein Building KS 158, Boston, MA, 02215, USA.
authors.forename: Faranak
authors.initials: F
authors.lastname: Farzan
authors.forename: Yunfen
authors.initials: Y
authors.lastname: Wu
authors.forename: Brad
authors.initials: B
authors.lastname: Manor
authors.forename: Elana M
authors.initials: EM
authors.lastname: Anastasio
authors.forename: Matthew
authors.initials: M
authors.lastname: Lough
authors.forename: Vera
authors.initials: V
authors.lastname: Novak
authors.forename: Patricia E
authors.initials: PE
authors.lastname: Greenstein
authors.forename: Alvaro
authors.initials: A
authors.lastname: Pascual-Leone
mesh_terms: D002524:Cerebellar Ataxia / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D002531:Cerebellum / Q000473:pathology*; D004576:Electromyography / Q000379:methods; D005260:Female; D005684:Gait / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D013647:Task Performance and Analysis; D050781:Transcranial Magnetic Stimulation / Q000379:methods; D016896:Treatment Outcome