title: Comparison of the 2010 and 2005 versions of the McDonald MRI criteria for dissemination-in-time in Taiwanese patients with classic multiple sclerosis.
abstract: In 2010, the International Panel on the Diagnosis of Multiple Sclerosis revised the 2005 version of the McDonald criteria. The revisions to MRI dissemination-in-time criteria include adoption of a new criterion by demonstration of simultaneous asymptomatic gadolinium-enhancing and nonenhancing lesions on baseline MRI scans. The purpose of this study was to demonstrate the diagnostic validity of the modified MRI dissemination-in-time criteria. We collected 80 patients with an initial clinical attack suggestive of an acute central nervous system demyelinating disease. The patients were followed for at least two years or until the development of definite multiple sclerosis. The nonconverters were taken as negative cases. Their baseline and follow-up brain MRI studies were retrospectively reviewed by two neuroradiologists. The 2010 version had higher sensitivity (68.2% vs. 45.5%), slightly lower specificity (80.6% vs. 83.3%), and higher accuracy (73.8% vs. 62.5%) than the 2005 version, but the differences were without statistical significance. The new criteria are more sensitive and accurate and specific just as the old criteria. They allow the diagnosis of definite multiple sclerosis in 34.1% patients at first presentation of the clinically isolated syndrome.
authors.affiliation: Department of Radiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.
authors.forename: Chun-Jen
authors.initials: CJ
authors.lastname: Hsueh
authors.forename: Hung-Wen
authors.initials: HW
authors.lastname: Kao
authors.forename: Shao-Yuan
authors.initials: SY
authors.lastname: Chen
authors.forename: Chung-Ping
authors.initials: CP
authors.lastname: Lo
authors.forename: Chia-Chun
authors.initials: CC
authors.lastname: Hsu
authors.forename: Dai-Wei
authors.initials: DW
authors.lastname: Liu
authors.forename: Wen-Lin
authors.initials: WL
authors.lastname: Hsu
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000453:epidemiology*; D009900:Optic Nerve / Q000473:pathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013116:Spinal Cord / Q000473:pathology; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult