title: Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells.
abstract: Type 2 immunity is critical for defense against cutaneous infections but also underlies the development of allergic skin diseases. We report the identification in normal mouse dermis of an abundant, phenotypically unique group 2 innate lymphoid cell (ILC2) subset that depended on interleukin 7 (IL-7) and constitutively produced IL-13. Intravital multiphoton microscopy showed that dermal ILC2 cells specifically interacted with mast cells, whose function was suppressed by IL-13. Treatment of mice deficient in recombination-activating gene 1 (Rag1(-/-)) with IL-2 resulted in the population expansion of activated, IL-5-producing dermal ILC2 cells, which led to spontaneous dermatitis characterized by eosinophil infiltrates and activated mast cells. Our data show that ILC2 cells have both pro- and anti-inflammatory properties and identify a previously unknown interactive pathway between two innate populations of cells of the immune system linked to type 2 immunity and allergic diseases.
authors.affiliation: The Centenary Institute, Newtown, Australia.
authors.forename: Ben
authors.initials: B
authors.lastname: Roediger
authors.forename: Ryan
authors.initials: R
authors.lastname: Kyle
authors.forename: Kwok Ho
authors.initials: KH
authors.lastname: Yip
authors.forename: Nital
authors.initials: N
authors.lastname: Sumaria
authors.forename: Thomas V
authors.initials: TV
authors.lastname: Guy
authors.forename: Brian S
authors.initials: BS
authors.lastname: Kim
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Mitchell
authors.forename: Szun S
authors.initials: SS
authors.lastname: Tay
authors.forename: Rohit
authors.initials: R
authors.lastname: Jain
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Forbes-Blom
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Philip L
authors.initials: PL
authors.lastname: Tong
authors.forename: Holly A
authors.initials: HA
authors.lastname: Bolton
authors.forename: David
authors.initials: D
authors.lastname: Artis
authors.forename: William E
authors.initials: WE
authors.lastname: Paul
authors.forename: Barbara
authors.initials: B
authors.lastname: Fazekas de St Groth
authors.forename: Michele A
authors.initials: MA
authors.lastname: Grimbaldeston
authors.forename: Graham
authors.initials: G
authors.lastname: Le Gros
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weninger
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000276:immunology; D002478:Cells, Cultured; D003872:Dermatitis / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D020405:Dermis / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism; D005434:Flow Cytometry; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology*; D018793:Interleukin-13 / Q000276:immunology / Q000378:metabolism; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism; D007376:Interleukin-2 / Q000276:immunology / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D036641:Microscopy, Fluorescence, Multiphoton; D012867:Skin / Q000276:immunology* / Q000378:metabolism; D014743:Videotape Recording
chemical_list: D018398:Homeodomain Proteins; D018793:Interleukin-13; D020381:Interleukin-17; D007376:Interleukin-2; C064658:RAG-1 protein; D049452:Green Fluorescent Proteins