title: Palladium-catalyzed direct C-H alkylation of electron-deficient pyrrole derivatives.
abstract: The apparent and the real: What looks like a Friedel-Crafts alkylation reaction of electron-deficient pyrroles is actually a Pd(II)-catalyzed, norbornene-mediated C-H activation reaction, in which the alkylation of the pyrrole core occurs by reductive elimination. As well as ethyl-1H-pyrrole-2-carboxylate, several other 2,3-disubstituted pyrroles underwent the selective C5 alkylation in good yield.
authors.affiliation: Lehrstuhl für Organische Chemie I and Catalysis Research Center (CRC), Technische Universität München, Lichtenbergstr. 4, 85747 Garching, Germany.
authors.forename: Lei
authors.initials: L
authors.lastname: Jiao
authors.forename: Thorsten
authors.initials: T
authors.lastname: Bach