title: Analysis of plasticizers and synthetic musks in cosmetic and personal care products by matrix solid-phase dispersion gas chromatography-mass spectrometry.
abstract: Matrix solid-phase dispersion (MSPD) and gas chromatography-mass spectrometry were used for the rapid determination of 18 plasticizers (phthalates and adipates), 7 polycyclic musks and 5 nitromusks, which makes a total of 30 targets, in both rinse-off and leave-on cosmetic formulations. The MSPD method was miniaturized and customized to avoid or minimize risks of phthalate contamination and to reduce residues and costs. The amount of sample and extraction solvent employed were 0.1g and 1mL, respectively. The procedure was optimized by means of an experimental design and under the optima conditions it showed satisfactory linearity, repeatability and intermediate precision. LOQs were, in general, in the low ngg(-1), and recoveries were quantitative for all the 18 plasticizers and the 12 fragrances. Twenty-six cosmetic products such as creams, emulsions, lotions, gels for the skin, bath and shower preparations, deodorants, hair-setting, hair-cleansing and hair-conditioning products, shaving products, and sunbathing products, were analyzed. Twenty-five out of thirty targets were detected in the samples. The most frequently found compounds were galaxolide and tonalide reaching concentrations above 0.1% (1000μgg(-1)), and diethyl phthalate (between 0.7 and 357μgg(-1)). The presence of banned substances (Regulation (EC) No. 1223/2009) such as dibutyl phthalate, diisobutyl phthalate, dimethoxyethyl phthalate, benzylbutyl phthalate, diethylhexyl phthalate, diisopentyl phthalate and dipentyl phthalate, musk ambrette and musk tibetene was confirmed in sixteen of the twenty-six personal care products (62%).
authors.affiliation: Department of Analytical Chemistry, Nutrition and Bromatology, Faculty of Chemistry, Campus Vida, University of Santiago de Compostela, Santiago de Compostela, E-15782, Spain. maria.llompart@usc.es
authors.forename: Maria
authors.initials: M
authors.lastname: Llompart
authors.forename: Maria
authors.initials: M
authors.lastname: Celeiro
authors.forename: J
authors.initials: J
authors.lastname: Pablo Lamas
authors.forename: Lucia
authors.initials: L
authors.lastname: Sanchez-Prado
authors.forename: Marta
authors.initials: M
authors.lastname: Lores
authors.forename: Carmen
authors.initials: C
authors.lastname: Garcia-Jares
mesh_terms: D000085:Acetates / Q000737:chemistry; D003358:Cosmetics / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D010476:Perfume / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D010795:Phthalic Acids / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D010968:Plasticizers / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D052616:Solid Phase Extraction / Q000379:methods*
chemical_list: D000085:Acetates; D003358:Cosmetics; D010476:Perfume; D010795:Phthalic Acids; D010968:Plasticizers; C007650:ethyl acetate