title: Efficient and General Synthesis of 3-Aminoindolines and 3-Aminoindoles via Copper-Catalyzed Three Component Coupling Reaction.
abstract: An efficient three component coupling (TCC) reaction toward a variety of 3-aminoindoline and 3-aminoindole derivatives has been developed. This cascade transformation proceeds via the copper-catalyzed coupling reaction between 2-aminobenzaldehyde, secondary amine, and alkyne leading to propargylamine intermediate, which, under the reaction conditions, undergoes cyclization into the indoline core. The latter, upon treatment with a base, smoothly isomerizes into indole. Alternatively, indole can directly be synthesized in a one-pot sequential reaction.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois, 60607-7061, USA; ; phone: (+1)-312-3553579.
authors.forename: Dmitri
authors.initials: D
authors.lastname: Chernyak
authors.forename: Natalia
authors.initials: N
authors.lastname: Chernyak
authors.forename: Vladimir
authors.initials: V
authors.lastname: Gevorgyan
keywords: 3-aminoidolines; 3-aminoindoles; copper; synthetic methods; three component coupling