title: Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C.
abstract: Reactive oxygen species (ROS) are a byproduct of the normal metabolism of oxygen and have important roles in cell signalling and homeostasis. An imbalance between ROS production and the cellular antioxidant defence system leads to oxidative stress. Environmental factors and genetic interactions play key roles in oxidative stress mediated pathologies. In this paper, we focus on cardiovascular diseases and obesity, disorders strongly related to each other; in which oxidative stress plays a fundamental role. We provide evidence of the key role played by p66(Shc) protein and protein kinase C (PKC) in these pathologies by their intracellular regulation of redox balance and oxidative stress levels. Additionally, we discuss possible therapeutic strategies aimed at attenuating the oxidative damage in these diseases.
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, Laboratory for Technologies of Advanced Therapies, University of Ferrara, Via Borsari 46, Ferrara, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: De Marchi
authors.forename: Federica
authors.initials: F
authors.lastname: Baldassari
authors.forename: Angela
authors.initials: A
authors.lastname: Bononi
authors.forename: Mariusz R
authors.initials: MR
authors.lastname: Wieckowski
authors.forename: Paolo
authors.initials: P
authors.lastname: Pinton
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D006801:Humans; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress; D011493:Protein Kinase C / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D055765:Shc Signaling Adaptor Proteins / Q000378:metabolism*; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1
chemical_list: D017382:Reactive Oxygen Species; C528024:SHC1 protein, human; D055765:Shc Signaling Adaptor Proteins; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1; D011493:Protein Kinase C