title: Switching prostaglandin analogues and 24-hour IOP fluctuations.
abstract: OBJECTIVE
  To evaluate the fluctuations in 24h mean intraocular pressure (IOP) when switching prostaglandin analogues in patients with glaucoma.
  
  
  METHODS
  Fourteen patients with primary open angle glaucoma were evaluated with monthly 24-hour IOP curves, using a monthly switching pattern of prostaglandin analogues and brinzolamide during 3 years of follow-up.
  
  
  RESULTS
  Average IOP and average fluctuation (peak to through difference) were significantly higher with brinzolamide than with any of the analogues. There was no significant difference in either parameter with the different prostaglandin analogues, regardless of the order in which they were evaluated, or even if a month on brinzolamide was intercalated between the analogues.
  
  
  CONCLUSIONS
  Brinzolamide was less effective than prostaglandin analogues in reducing 24-hour mean IOP and its fluctuations. Switching analogues had no significant effect on mean IOP or mean IOP fluctuations.
authors.affiliation: Departamento de Glaucoma, Asociación para evitar la ceguera en México, Hospital Dr. Luis Sánchez Bulnes, México City, Mexico. fegica@hotmail.com
authors.forename: F
authors.initials: F
authors.lastname: Gil-Carrasco
authors.forename: M
authors.initials: M
authors.lastname: Turati-Acosta
authors.forename: O
authors.initials: O
authors.lastname: Albis-Donado
authors.forename: H
authors.initials: H
authors.lastname: Bello-López-Portillo
authors.forename: C
authors.initials: C
authors.lastname: Sánchez-Noguera
authors.forename: K
authors.initials: K
authors.lastname: Soto-Ortiz
mesh_terms: D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011465:Prostaglandins, Synthetic / Q000494:pharmacology* / Q000627:therapeutic use; D013449:Sulfonamides / Q000494:pharmacology* / Q000627:therapeutic use; D013843:Thiazines / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D011465:Prostaglandins, Synthetic; D013449:Sulfonamides; D013843:Thiazines; C111827:brinzolamide