title: [Relationship between IDH1 mutation and clinic pathologic features in human supratentorial WHO grade II gliomas].
abstract: OBJECTIVE
  To investigate the relationship between isocitrate dehydrogenase 1 (IDH1) mutation and clinicopathological features in human supratentorial WHO grade II gliomas.
  
  
  METHODS
  Ninety five supratentorial WHO grade II glioma patients were treated in our department from January 2009 to January 2011. The clinical data and tumor samples of each patient were collected. IDH1 mutation in the tumor was measured by sequencing the IDH1 gene of tumor specimen. The relationship between IDH1 mutation and the clinicopathological features was analyzed.
  
  
  RESULTS
  There were 69 cases (72.6%) with IDH1 mutations were found, all of which were R132H type mutations. The mutation rates of diffuse astrocytoma, oligodendroglioma and oligoastrocytoma were 73.6%, 68.8% and 73.1% respectively. The mean ages of IDH1 mutant group and wild type group were significantly different [(39 6 +/- 7.4) yr. vs. (46.9 +/- 11.6) yr., P < 0.05). The mutant rates of patients aged > or = 50 years and < 50 years were 43.8% and 78.5% respectively (P < 0.05), while those of male patients and female patients were 68.6% and 77.3% respectively (P > 0.05). The mutant rates of patients whose tumor > or = 5 cm and < 5 cm were 60.0% and 90.0% respectively (P < 0.05), while those of monolobe involvement group and deepen structures involvement group were 93.3% and 32.0% respectively (P < 0.05).
  
  
  CONCLUSIONS
  The mutation of IDH1 in supratentorial WHO grade II glioma is common, and is associated with patients' age, tumor size and tumor location.
authors.affiliation: Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Jun-Jia
authors.initials: JJ
authors.lastname: Tang
authors.forename: Fei
authors.initials: F
authors.lastname: Xie
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Dou-Dou
authors.initials: DD
authors.lastname: Zhang
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Liu
authors.forename: Qing
authors.initials: Q
authors.lastname: Mao
mesh_terms: D000328:Adult; D001254:Astrocytoma; D001932:Brain Neoplasms / Q000473:pathology*; D005260:Female; D005910:Glioma / Q000473:pathology*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009837:Oligodendroglioma
chemical_list: D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human