title: Effect of selected dimethylaminochalcones on some mitochondrial activities.
abstract: Chalcones and their synthetic cyclic analogues have been shown to possess a full scale of biological activities in a variety of experimental systems. They were assessed to be mostly effective in defense against free radicals in the organism, but several compounds exhibited cytotoxic pro-oxidant activities. The respiratory response and antioxidant status in mitochondria were investigated upon addition of 4'-dimethylaminochalcone (1a) and its cyclic analogues, (E)-2-(4'-((CH3)2 N)-benzylidene)-1-indanone (1b), -1-tetralone (1c), and -1-benzosuberone (1d). Selected structures were able to change the respiratory response of mitochondria and showed an ability to modify mitochondrial metabolic and redox efficiency, though they did not indicate redox reactivity towards glutathione in adduct-free incubations. The results of the study indicate that -chalcone and -tetralone derivatives cause suppression of reactive oxygen species affecting mitochondrial respiration by mild uncoupling. In addition, (E)-2-(4'-((CH3)2 N)-indanone (1b), and to a greater extent, -benzosuberone (1d), showed pro-oxidant effects, which partially explain their cytotoxicity.
authors.affiliation: Department of Medical and Clinical Biochemistry, Faculty of Medicine, P J Šafárik University in Košice, Košice, Slovak Republic. janka.vaskova@upjs.sk
authors.forename: Janka
authors.initials: J
authors.lastname: Vašková
authors.forename: Renáta
authors.initials: R
authors.lastname: Reisch
authors.forename: Ladislav
authors.initials: L
authors.lastname: Vaško
authors.forename: Martina
authors.initials: M
authors.lastname: Poškrobová
authors.forename: Ivan
authors.initials: I
authors.lastname: Kron
authors.forename: Juraj
authors.initials: J
authors.lastname: Guzy
authors.forename: Pál
authors.initials: P
authors.lastname: Perjési
mesh_terms: D000818:Animals; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D008099:Liver / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008928:Mitochondria / Q000187:drug effects*; D015394:Molecular Structure; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D044024:Tetralones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C480828:4-dimethylaminochalcone; D047188:Chalcones; D017382:Reactive Oxygen Species; D044024:Tetralones