title: Management of sarcomatoid salivary duct carcinoma of the submandibular gland duct with coexisting seropositive human immunodeficiency virus.
abstract: BACKGROUND
  Sarcomatoid salivary duct carcinoma of the submandibular gland is extremely rare. This paper highlights the impact of surgery and adjuvant radiation therapy on the outcome of this disease.
  
  
  METHODS
  A 59-year-old man with human immunodeficiency virus presented with a painless, rapidly growing left neck mass. Biopsy followed by surgical excision of the left submandibular gland revealed sarcomatoid salivary duct carcinoma of the submandibular gland duct with perineural invasion and close margins, for which he underwent adjuvant radiotherapy. Post-operative positron emission tomography and computed tomography revealed no residual or metastatic disease. Pathological analysis of tumour-node-metastasis staging revealed a T2 N0 M0 (stage II) tumour.
  
  
  RESULTS
  The patient tolerated his treatment without serious acute or long-term side effects. There was no evidence of disease on comprehensive examination or on positron emission tomography or computed tomography scans at the 4.6-year follow up.
  
  
  CONCLUSIONS
  Surgery followed by adjuvant radiotherapy provided practical locoregional control with acceptable toxicity. Further detailed case reports are warranted to optimise the management of this rare malignancy.
authors.affiliation: Department of Radiation Oncology, Beth Israel Medical Center, New York, NY 10003, USA. Waleed246@gmail.com
authors.forename: W F
authors.initials: WF
authors.lastname: Mourad
authors.forename: K S
authors.initials: KS
authors.lastname: Hu
authors.forename: R A
authors.initials: RA
authors.lastname: Shourbaji
authors.forename: L B
authors.initials: LB
authors.lastname: Harrison
mesh_terms: D003131:Combined Modality Therapy; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013363:Submandibular Gland / Q000473:pathology / Q000601:surgery; D013365:Submandibular Gland Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*