title: Role of G308 promoter variant of tumor necrosis factor alpha gene on weight loss and metabolic parameters after a high monounsaturated versus a high polyunsaturated fat hypocaloric diets.
abstract: OBJECTIVE
  The aim of our study was to investigate the influence of G-308 promoter variant of the tumor necrosis factor (TNF) alpha gene on metabolic changes and weight loss secondary to a high monounsaturated fat vs a high polyunsaturated fat hypocaloric diet in obese subjects.
  
  
  METHODS
  A sample of 261 obese subjects were enrolled in a consecutive prospective way, from May 2011 to July 2012 in a tertiary hospital. In the basal visit, patients were randomly allocated during 3 months to Diet M (high monounsaturated fat hypocaloric diet) and Diet P (high polyunsaturated fat hypocaloric diet).
  
  
  RESULTS
  One hundred and ninety seven patients (73.2%) had the genotype G-308G and 64 (26.8%) patients had the genotype G-308A. There were no significant differences between the effects (on weight, body mass index (BMI), waist circumference, fat mass) in either genotype group with both diets. With the diet type P and in genotype G-308G, glucose levels (-6.7(22.1)mg/dl vs -3.7(2.2)mg/dl: p = 0.02), HOMA-R (-0.6(2.1)units vs -0.26(3.1)units: p = 0.01), insulin levels (-1.7(6.6)UI/L vs -0.6(7.1)UI/L: p = 0.009), total cholesterol levels (-15.3(31.1)mg/dl vs -8.4(22.1)mg/dl: p = 0.01), LDL cholesterol levels (-10.7(28.1)mg/dl vs -3.8(21.1)mg/dl: p = 0.008) and triglycerides (-12.1(52.1)mg/dl vs -6.6(43.1)mg/dl: p = 0.02) decreased.
  
  
  CONCLUSIONS
  Carriers of the G-308G promoter variant of TNF alpha gene have a better metabolic response than A-308 obese with a high polyunsaturated fat hypocaloric diet.
authors.affiliation: Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Río Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es
authors.forename: Daniel A
authors.initials: DA
authors.lastname: de Luis
authors.forename: Rocío
authors.initials: R
authors.lastname: Aller
authors.forename: Olatz
authors.initials: O
authors.lastname: Izaola
authors.forename: Manuel
authors.initials: M
authors.lastname: Gonzalez Sagrado
authors.forename: Rosa
authors.initials: R
authors.lastname: Conde
mesh_terms: D054392:Adipokines / Q000097:blood; D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003131:Combined Modality Therapy; D016207:Cytokines / Q000097:blood; D004038:Diet, Reducing; D004041:Dietary Fats / Q000008:administration & dosage*; D005081:Exercise Therapy; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy / Q000235:genetics* / Q000628:therapy; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D015431:Weight Loss / Q000235:genetics*
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D016207:Cytokines; D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D007328:Insulin; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D002784:Cholesterol
keywords: Dieta hipocalórica; G308 TNF-alpha polymorphism; Hypocaloric diet; Obesidad; Obesity; Polimorfismo G-308 del factor de necrosis tumoral α