title: Matrix type transdermal therapeutic system containing captopril: formulation optimization, in vitro and ex vivo characterization.
abstract: Transdermal therapeutic systems (TTS) containing captopril were developed by using synthetic and pH independent polymers, Eudragit RL 100 and RS 100. The formulations were characterized in terms of their appearance, thickness, captopril content, in vitro release rate and diffusion profiles. In vitro release studies demonstrated controlled release for each formulation developed. In viro and ex vivo diffusion rate studies were performed through various synthetic membranes with different thickness, pore size and type (hydrophilic and hydrophobic) and through human skin by using Franz diffusion cells. Type of membrane and composition of the formulation affected the diffusion profiles of captopril from the transdermal therapeutic systems. Transdermal therapeutic systems containing captopril were successfully prepared and especially two of the formulations (F15 and F16) are considered to be suitable to administer captopril via skin.
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Technology, Marmara University, 34668 Haydarpaşa, Istanbul, Turkey. osipahigil@marmara.edu.tr
authors.forename: Oya
authors.initials: O
authors.lastname: Kerimoğlu
authors.forename: Ebru
authors.initials: E
authors.lastname: Keskin
authors.forename: Betül
authors.initials: B
authors.lastname: Dortunç
authors.forename: Sela
authors.initials: S
authors.lastname: Anah
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000279:Administration, Cutaneous; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D002216:Captopril / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004058:Diffusion; D004337:Drug Carriers; D005260:Female; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D066298:In Vitro Techniques; D007700:Kinetics; D016062:Porosity; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D057968:Transdermal Patch
chemical_list: D000180:Acrylic Resins; D000806:Angiotensin-Converting Enzyme Inhibitors; D003692:Delayed-Action Preparations; D004337:Drug Carriers; C050528:Eudragit RS; D002216:Captopril