title: In vitro cell tests of pancreatic malignant tumor cells by photothermotherapy based on DMSO porous silicon colloids.
abstract: Dimethyl sulfoxide porous silicon (DMSO-PSi) colloid in which DMSO was used as a surfactant suitable for inhibiting the agglomeration of PSi nanoparticles was prepared for use in cancer photothermotherapy. The photothermal effect of the DMSO-PSi colloid was found to be high enough to destroy cancer cells (T = ∼52 °C). The mean particle size of the PSi nanoparticles in the DMSO-PSi colloid was 67 nm, which is low enough to flow through blood vessels without causing a blockage. The DMSO-PSi colloid in combination with an NIR laser resulted in a cell viability of 5.70%, which is a sufficiently high cytotoxic effect.
authors.affiliation: Department of Materials Science and Engineering, Inha University, 253 Yonghyeon-dong, Incheon, 402-751, Republic of Korea.
authors.forename: Chanseok
authors.initials: C
authors.lastname: Hong
authors.forename: Chongmu
authors.initials: C
authors.lastname: Lee
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000528:radiation effects; D003102:Colloids; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D054023:Lasers, Semiconductor / Q000627:therapeutic use; D028022:Low-Level Light Therapy / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D010316:Particle Size; D016062:Porosity; D012825:Silicon / Q000737:chemistry
chemical_list: D003102:Colloids; D004121:Dimethyl Sulfoxide; D012825:Silicon