title: Relationship between brain and liver oxidative state and maximum lifespan potential of different fish species.
abstract: The aim of the present study is to determine whether a relationship exists between the maximum lifespan potential (MLSP) of different fish species (Squalius pyrenaicus, Cyprinus carpio, Carassius auratus, Luciobarbus sclateri and Oncorhynchus mykiss) and the oxidative state of brain and liver. For this purpose, the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase, glutathione peroxidase (GPX), glutathione reductase (GR), glutathione S-transferase (GST) and DT-diaphorase (NAD(P)H:quinone oxidoreductase1) were measured together with the lipid peroxidation degree (malondialdehyde, MDA) in liver and brain tissues of the collected species. Only the brain tissue manifested a higher activity of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, and glutathione S-transferase in addition to a negative correlation between the values of MDA and MLSP among the different fish species. Hypotheses are proposed from the analysis of the obtained results that open new areas of research and converge on the importance of the theory of free radicals in the processes that condition the maximum life expectancy of an animal species.
authors.affiliation: Departamento de Zoología, Facultad de Ciencias, Universidad de Granada, Granada, Spain. anasanz@ugr.es
authors.forename: A
authors.initials: A
authors.lastname: Sanz
authors.forename: C E
authors.initials: CE
authors.lastname: Trenzado
authors.forename: H
authors.initials: H
authors.lastname: Botello Castro
authors.forename: M J
authors.initials: MJ
authors.lastname: López-Rodríguez
authors.forename: J M
authors.initials: JM
authors.lastname: Tierno de Figueroa
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000201:enzymology* / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D005399:Fishes / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008017:Life Expectancy; D015227:Lipid Peroxidation / Q000502:physiology; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D016660:NAD(P)H Dehydrogenase (Quinone); D005980:Glutathione Reductase; D005982:Glutathione Transferase