title: Impact of catalytic iron on mortality in patients with acute coronary syndrome exposed to iodinated radiocontrast-The Iscom Study.
abstract: BACKGROUND
  Catalytic iron (CI) mediates vascular injury by generating reactive oxygen species. We evaluated role of CI in predicting mortality in patients with acute coronary syndrome (ACS) and studied association of contrast nephropathy with CI levels.
  
  
  METHODS
  We investigated 806 patients with ACS undergoing contrast exposure for a cardiac procedure who were followed up for 30 days.
  
  
  RESULTS
  Overall mortality was 1.6% at 30 days. Catalytic iron at baseline predicted mortality with CI levels significantly higher in those who died, 0.45 μmol/L (0.37, 0.68) compared with survivors 0.31 μmol/L (0.21, 0.40); P = .004. Catalytic iron was associated with increased risk of death in the highest quartile compared with lower 3 quartiles (hazard ratio 7.88, P = .001) after adjustment for age, diabetes, ST deviation, Killip class, ejection fraction, baseline creatinine, hemoglobin level, and troponin. Fifty-five patients (6.8%) developed contrast nephropathy. Patients with contrast nephropathy had a 27% increase in median CI levels from baseline up to 48 hours compared with a marginal 2.9% increase in those without contrast nephropathy (0.37, 0.14 μmol/L to 0.47, 0.20 μmol/L versus 0.35, 0.12 μmol/L to 0.36, 0.14 μmol/L, P < .0001). Patients with contrast nephropathy had significantly higher mortality compared with those without contrast nephropathy (9.1% vs 1.1%, P = .001).
  
  
  CONCLUSIONS
  High baseline CI levels predicted mortality in patients with ACS. Occurrence of contrast nephropathy was associated with rise in CI levels and higher mortality. Therapeutic options to buffer or chelate CI may have beneficial effects on mortality in this setting.
authors.affiliation: Department of Cardiology, Bhailal Amin General Hospital, Baroda, Gujarat, India. lelesuhas@yahoo.com
authors.forename: Suhas S
authors.initials: SS
authors.lastname: Lele
authors.forename: Banibrata N
authors.initials: BN
authors.lastname: Mukhopadhyay
authors.forename: Mohan M
authors.initials: MM
authors.lastname: Mardikar
authors.forename: Tejas A
authors.initials: TA
authors.lastname: Patel
authors.forename: Apoorva K
authors.initials: AK
authors.lastname: Vasavada
authors.forename: Darshan N
authors.initials: DN
authors.lastname: Banker
authors.forename: Ketan D
authors.initials: KD
authors.lastname: Kapasi
authors.forename: Virendra C
authors.initials: VC
authors.lastname: Chauhan
authors.forename: Kamaldeep C
authors.initials: KC
authors.lastname: Chawla
authors.forename: Soma R
authors.initials: SR
authors.lastname: Raju
authors.forename: Shirish S
authors.initials: SS
authors.lastname: Hiremath
authors.forename: Sashi S
authors.initials: SS
authors.lastname: Chinchole
authors.forename: Mohan M
authors.initials: MM
authors.lastname: Rajapurkar
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000000981:diagnostic imaging*; D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced* / Q000401:mortality; D003287:Contrast Media / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007194:India / Q000453:epidemiology; D007472:Iohexol / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D015996:Survival Rate / Q000639:trends
chemical_list: D003287:Contrast Media; D007472:Iohexol; D003404:Creatinine