title: Grouping of residual solvents present in pharmaceuticals using experimental planning and chemometric methods.
abstract: The main effects of six experimental factors on the efficiency of HS (headspace) extraction in headspace gas chromatography--flame ionization detector (HS-GC-FID) determination of twenty organic solvents routinely used in production of pharmaceuticals were obtained on the basis of the results of experiments carried out according to the Plackett-Burman factorial design. The effects were used as a basis for grouping the solvents into five groups, the solvents belonging to a group responded similarly to changes of HS conditions. To this end, visualization approaches were used as well as chemometric methods: cluster analysis (CA) and principal component analysis (PCA). Moreover, the most important HS experimental factors were selected for further optimization of the HS-GC determination procedure.
authors.affiliation: Teva Operations Poland, Mogilska 80, 31-546 Kraków, Poland. katarzyna.grodowska@teva.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Grodowska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Parczewski
mesh_terms: D002849:Chromatography, Gas; D016000:Cluster Analysis; D004340:Drug Contamination; D005410:Flame Ionization; D016014:Linear Models; D004364:Pharmaceutical Preparations / Q000032:analysis*; D025341:Principal Component Analysis; D012997:Solvents / Q000032:analysis* / Q000145:classification; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations; D012997:Solvents