title: Sciadopitysin: active component from Taxus chinensis for anti-Alzheimer's disease.
abstract: Five taxane diterpenoids derived from the 95% ethanol extract of Taxus chinensis were tested for the inhibitory activities on amyloid-beta (Aβ) peptide aggregation. Using thioflavin-T fluorescence assay, sciadopitysin was found to exhibit the most potency against Aβ aggregation and the formation of fibrils. Further cellular assay indicated that sciadopitysin increased the cell viability of SH-SY5Y cell and demonstrated neuroprotection against Aβ protein-induced insult in primary cortical neurons. According to the authors' best knowledge, this is the first report that sciadopitysin can inhibit the Aβ aggregation and reduce Aβ-induced toxicity in the primary cortical neurons.
authors.affiliation: a School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou , China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Gu
authors.forename: Yanping
authors.initials: Y
authors.lastname: Li
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Chen
authors.forename: Peifen
authors.initials: P
authors.lastname: Yao
authors.forename: Tianmiao
authors.initials: T
authors.lastname: Ou
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors*; D044946:Biflavonoids / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D006801:Humans; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D020946:Taxus / Q000737:chemistry*; D018675:Toxicity Tests
chemical_list: D016229:Amyloid beta-Peptides; D044946:Biflavonoids; D018696:Neuroprotective Agents; C086243:sciadopitysin