title: A unified synthetic strategy to the Cryptocarya family of natural products exploiting Anion Relay Chemistry (ARC).
abstract: A unified synthetic strategy to the Cryptocarya family of natural products has been achieved employing four-component fragment unions in a "single flask" exploiting Anion Relay Chemistry (ARC). Functionalization of the ARC adducts permits rapid construction of five polyhydroxylated di- and tetrahydropyrone natural products of the Cryptocarya class (1-5), in a total of 7-9 steps from commercially available materials.
authors.affiliation: Department of Chemistry, Laboratory for Research on the Structure of Matter, and the Monell Chemical Senses Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Bruno
authors.initials: B
authors.lastname: Melillo
authors.forename: Amos B
authors.initials: AB
authors.lastname: Smith
mesh_terms: D000838:Anions / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D031369:Cryptocarya / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000838:Anions; D001688:Biological Products