title: Is there a role for adrenaline during cardiopulmonary resuscitation?
abstract: OBJECTIVE
  To critically evaluate the recent data on the influence adrenaline has on outcome from cardiopulmonary resuscitation.
  
  
  RESULTS
  Two prospective controlled trials in out-of-hospital cardiac arrest (OHCA) have indicated that adrenaline increases the rate of return of spontaneous circulation (ROSC), but neither was sufficiently powered to determine the long-term outcomes. Several observational studies document higher ROSC rates in patients receiving adrenaline after OHCA, but these also document an association between receiving adrenaline and worse long-term outcomes.
  
  
  CONCLUSIONS
  Appropriately powered prospective, placebo-controlled trials of adrenaline in cardiac arrest are essential if the role of this drug is to be defined reliably.
authors.affiliation: Royal United Hospital, Bath, UK. jerry.nolan@nhs.net
authors.forename: Jerry P
authors.initials: JP
authors.lastname: Nolan
authors.forename: Gavin D
authors.initials: GD
authors.lastname: Perkins
mesh_terms: D000328:Adult; D001775:Blood Circulation / Q000187:drug effects*; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D004837:Epinephrine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D058687:Out-of-Hospital Cardiac Arrest / Q000188:drug therapy* / Q000401:mortality; D011446:Prospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D004837:Epinephrine