title: Gastrin-releasing peptide as a molecular target for inflammatory diseases: an update.
abstract: Gastrin-releasing peptide (GRP) is a neuropeptide that acts through G protein coupled receptors and is involved in signal transmission in both the central and peripheral nervous systems. Its receptor, gastrin-releasing peptide receptor (GRPR), is expressed by various cell types, and it is overexpressed in cancer cells. In recent years, studies have suggested the relationship of GRP and inflammatory diseases. RC-3095, a selective GRPR antagonist, was found to have antiinflammatory properties in models of arthritis, gastritis, uveitis and sepsis. Furthermore, GRP mediates air pollutioninduced airway hyperreactivity and airway inflammation in mice. In conclusion, GRP and its receptor are relevant to the inflammatory response, being a potential therapeutic target several diseases are related to inflammation.
authors.affiliation: Master Program in Health Sciences, Universidade do Sul de Santa Catarina UNISUL, Tubarao, Brazil. fabricia.petronilho@unisul.br
authors.forename: Fabricia
authors.initials: F
authors.lastname: Petronilho
authors.forename: Lucineia Gainski
authors.initials: LG
authors.lastname: Danielski
authors.forename: Rafael
authors.initials: R
authors.lastname: Roesler
authors.forename: Gilberto
authors.initials: G
authors.lastname: Schwartsmann
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
mesh_terms: D000397:Air Pollution / Q000009:adverse effects; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001839:Bombesin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D019886:Gastrin-Releasing Peptide / Q000037:antagonists & inhibitors*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D051379:Mice; D058990:Molecular Targeted Therapy; D015213:Neuroimmunomodulation; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use; D018004:Receptors, Bombesin / Q000235:genetics / Q000378:metabolism*; D012130:Respiratory Hypersensitivity / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D010446:Peptide Fragments; D018004:Receptors, Bombesin; C071363:bombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)-; D019886:Gastrin-Releasing Peptide; D001839:Bombesin