title: T cell factor 1 is required for group 2 innate lymphoid cell generation.
abstract: Group 2 innate lymphoid cells (ILC2) are innate lymphocytes that confer protective type 2 immunity during helminth infection and are also involved in allergic airway inflammation. Here we report that ILC2 development required T cell factor 1 (TCF-1, the product of the Tcf7 gene), a transcription factor also implicated in T cell lineage specification. Tcf7(-/-) mice lack ILC2, and were unable to mount ILC2-mediated innate type 2 immune responses. Forced expression of TCF-1 in bone marrow progenitors partially bypassed the requirement for Notch signaling in the generation of ILC2 in vivo. TCF-1 acted through both GATA-3-dependent and GATA-3-independent pathways to promote the generation of ILC2. These results are reminiscent of the critical roles of TCF-1 in early T cell development. Hence, transcription factors that underlie early steps of T cell development are also implicated in the development of innate lymphoid cells.
authors.affiliation: Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Yang
authors.forename: Laurel A
authors.initials: LA
authors.lastname: Monticelli
authors.forename: Steven A
authors.initials: SA
authors.lastname: Saenz
authors.forename: Anthony Wei-Shine
authors.initials: AW
authors.lastname: Chi
authors.forename: Gregory F
authors.initials: GF
authors.lastname: Sonnenberg
authors.forename: Jiangbo
authors.initials: J
authors.lastname: Tang
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: De Obaldia
authors.forename: Will
authors.initials: W
authors.lastname: Bailis
authors.forename: Jerrod L
authors.initials: JL
authors.lastname: Bryson
authors.forename: Kristin
authors.initials: K
authors.lastname: Toscano
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Angela
authors.initials: A
authors.lastname: Haczku
authors.forename: Warren S
authors.initials: WS
authors.lastname: Pear
authors.forename: David
authors.initials: D
authors.lastname: Artis
authors.forename: Avinash
authors.initials: A
authors.lastname: Bhandoola
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology*; D001854:Bone Marrow Cells / Q000276:immunology*; D002454:Cell Differentiation; D019070:Cell Lineage; D002478:Cells, Cultured; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics / Q000378:metabolism*; D007113:Immunity, Innate; D008214:Lymphocytes / Q000276:immunology*; D054503:Lymphoid Progenitor Cells / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009559:Nippostrongylus / Q000276:immunology*; D015398:Signal Transduction / Q000235:genetics; D017206:Strongylida Infections / Q000276:immunology*; D019076:Transgenes / Q000235:genetics
chemical_list: D051538:Hepatocyte Nuclear Factor 1-alpha; C496488:Hnf1a protein, mouse