title: Development of multi scale structured Al/AI2O3 nanowires for controlled cell guidance.
abstract: Cell responses to surface and contact cell guidance are of great interest in bio-applications especially on nano- and micro scale features. Recently we showed selective cell responses on Al/Al2O3, bi-phasic nanowires (NWs). In this context, Al/Al2O3 NWs were synthesized by the chemical vapor deposition of (tBuOAIH2)2. Afterwards, linear periodic nano- and micro structured NWs were formed using laser interference lithography (LIL) technique to study the contact guidance of neurons from rat dorsal root ganglion (DRG), human umbilical vein smooth muscle cells (HUVSMC), human umbilical vein endothelial cells (HUVEC) and human osteoblast (HOB). LIL treatment did not alter surface chemistry of NWs. From our preliminary research LIL patterned NWs lead to alignment of axons contrary to non-patterned NWs. Morphology of HUVSMC changed from poly- to linear shapes and strong alignment was observed while HUVEC and HOB were not affected.
authors.affiliation: Leibniz-lnstitute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany.
authors.forename: Juseok
authors.initials: J
authors.lastname: Lee
authors.forename: Marina M
authors.initials: MM
authors.lastname: Miró
authors.forename: Cagri K
authors.initials: CK
authors.lastname: Akkan
authors.forename: Ayman
authors.initials: A
authors.lastname: Haidar
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Metzger
authors.forename: Lukas K
authors.initials: LK
authors.lastname: Schwarz
authors.forename: Vladimir
authors.initials: V
authors.lastname: Zaporojtchenko
authors.forename: Karl H
authors.initials: KH
authors.lastname: Schäfer
authors.forename: Hashim
authors.initials: H
authors.lastname: Abdul-Khaliq
authors.forename: Michael
authors.initials: M
authors.lastname: Veith
authors.forename: Cenk
authors.initials: C
authors.lastname: Aktas
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D000537:Aluminum Oxide / Q000737:chemistry*; D000818:Animals; D002477:Cells / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000166:cytology / Q000648:ultrastructure; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology; D006801:Humans; D007834:Lasers; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D053770:Nanowires / Q000737:chemistry* / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology / Q000648:ultrastructure; D056951:Photoelectron Spectroscopy; D011327:Printing; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000535:Aluminum; D000537:Aluminum Oxide