title: [Primary-refractory forms of Hodgkin's lymphoma].
abstract: Retrospective analysis defined risk factors of primary-refractory course of Hodgkin's lymphoma as well as adverse prognostic factors, efficacy of I and II therapy lines in patients with primary-refractory forms of Hodgkin's lymphoma. By means of discriminant analysis risk factors were as follows: massive tumor lesion, chemotherapy as compared to chemoradiotherapy in the I line, intoxication symptoms, IPS > or = 3, LDH level more than 1,5xULN, late beginning of specialized treatment (over 12 months from initial symptoms of disease), damage of 5 and more areas of lymph nodes, age more than 45 years, increase of ESR higher than 30 mm/h in Stage B and 50 MM/H in Stage A, Stage IV of disease, leukocyte rate higher than 15 x 10(9)/l, presence of more than one extranodal lesion. As a result there were revealed 4 prognostic factors unfavorably influencing on survival rates in primary-refractory forms of Hodgkin's lymphoma with originally Stages II/IV with poor prognosis. The worst 5-year survival rates were found in the presence of 3 and 4 adverse prognostic factors. These circumstances should be taken into consideration choosing optimal treatment and predicting of success of the proposed treatment.
authors.forename: L V
authors.initials: LV
authors.lastname: Filatova
authors.forename: A A
authors.initials: AA
authors.lastname: Tarasenkova
authors.forename: M L
authors.initials: ML
authors.lastname: Gershanovich
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Semiglazova
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D005260:Female; D006689:Hodgkin Disease / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis