title: The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients.
abstract: We evaluated two polymorphisms at CYP1A2 (*1C and *1F) in a sample of 108 European-derived patients with schizophrenia and their influence on the pro-convulsive effect of clozapine. We found the *1F/*1F genotype to be significantly associated with seizures, and no relationship was observed with combinations of *1F and *1C alleles.
authors.affiliation: Departamento de Biologia Geral, Universidade Federal Fluminense, Niterói, Brazil. fabianabk@yahoo.com
authors.forename: Fabiana Barzotti
authors.initials: FB
authors.lastname: Kohlrausch
authors.forename: Clarissa
authors.initials: C
authors.lastname: Severino-Gama
authors.forename: Maria Inês
authors.initials: MI
authors.lastname: Lobato
authors.forename: Paulo
authors.initials: P
authors.lastname: Belmonte-de-Abreu
authors.forename: Angel
authors.initials: A
authors.lastname: Carracedo
authors.forename: Mara Helena
authors.initials: MH
authors.lastname: Hutz
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001938:Brazil / Q000453:epidemiology; D003024:Clozapine / Q000009:adverse effects*; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D004569:Electroencephalography; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced* / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012333:RNA, Messenger; D012559:Schizophrenia / Q000188:drug therapy; D044465:White People
chemical_list: D014150:Antipsychotic Agents; D012333:RNA, Messenger; D019388:Cytochrome P-450 CYP1A2; D003024:Clozapine
keywords: Adverse effects; Cytochrome; Pharmacogenetics