title: Preoperative levels of matrix metalloproteinase-7 and -9 and tissue inhibitor of matrix metalloproteinase-1 relation to pathologic parameters in bladder carcinoma patients.
abstract: Our aim was to test the hypothesis that preoperative serum levels of matrix metalloproteinase-7 (MMP-7) and -9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) levels correlate with pathological features. Serum levels of MMP-7, and MMP-9 and TIMP-1 were determined in 90 bladder cancer patients and 40 healthy controls using an enzyme linked immunosorbent assay. Preoperative serum MMP-7 and MMP-9 levels were significantly higher in cancer patients than control groups (p<0.001). In contast, serum TIMP-1 levels were lower (p<0.001). Alteration in MMP-7, and MMP-9, and TIMP-1 production may contribute to tumor angiogenesis and be associated with clinic-pathological features.
authors.affiliation: Department of Urology, Yuzuncu Yil University Medical Faculty, Van, Turkey. drmustafa23@yahoo.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gunes
authors.forename: Ahu Serap
authors.initials: AS
authors.lastname: Kemik
authors.forename: Necip
authors.initials: N
authors.lastname: Pirincci
authors.forename: Ilhan
authors.initials: I
authors.lastname: Gecit
authors.forename: Kerem
authors.initials: K
authors.lastname: Taken
authors.forename: Mehmet Bilgehan
authors.initials: MB
authors.lastname: Yuksel
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kaba
authors.forename: Recep
authors.initials: R
authors.lastname: Eryilmaz
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D020783:Matrix Metalloproteinase 7 / Q000097:blood*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*; D001743:Urinary Bladder / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000097:blood* / Q000378:metabolism / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; C560822:TIMP1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9