title: Are metabolic syndrome antecedents in prepubertal children associated with being born idiopathic large for gestational age?
abstract: BACKGROUND
  Being born large for gestational age (LGA) is a risk factor for development of metabolic syndrome (MS) in adolescents and adults.
  
  
  OBJECTIVE
  To evaluate prepubertal children born idiopathic LGA to non-obese mothers without gestational diabetes or glucosuria with respect to the presence of MS antecedents.
  
  
  METHODS
  We conducted a cross-sectional study to compare 40 (19 F) LGA-born prepubertal children of a mean age of 6.1 ± 2.5 yr and 49 (25 F) appropriate for gestational age (AGA)-born body mass index (BMI)-matched peers of a mean age of 5.4 ± 1.8 yr with respect to their anthropometric data, blood pressure measurements, fasting serum glucose and insulin levels, homeostasis model assessment-insulin resistance (HOMA-IR), and lipids and atherogenic index (AI) [triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C)]. HOMA-IR > 2.5 was used to define IR. HDL-C ≤ 40 mg/dL and TG ≥ 110 mg/dL were used to define dyslipidemia. Both groups were further divided into subgroups as obese and non-obese according to their BMI percentiles and the analyses were repeated.
  
  
  RESULTS
  Non-obese LGA children had higher waist circumference (WC) standard deviation scores (SDSs) than BMI-matched AGA-born peers (p = 0.024). There were no significant differences between pooled, obese and non-obese subgroups of LGA-born children and their AGA counterparts with respect to dyslipidemia and IR. AI was higher in non-obese LGA children than in AGA counterparts (p = 0.028).
  
  
  CONCLUSIONS
  Non-obese idiopathic LGA-born children have higher AIs than AGA-born counterparts in the absence of IR. WC seems to be a good clinical screening tool in identifying at risk of non-obese LGA children. Further studies are needed to evaluate MS antecedents in idiopathic LGA-born children.
authors.affiliation: Paediatric Endocrinology and Diabetes Unit, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey.
authors.forename: Ceren
authors.initials: C
authors.lastname: Çetin
authors.forename: Ahmet
authors.initials: A
authors.lastname: Uçar
authors.forename: Firdevs
authors.initials: F
authors.lastname: Bas
authors.forename: Şükran
authors.initials: Ş
authors.lastname: Poyrazoğlu
authors.forename: Rüveyde
authors.initials: R
authors.lastname: Bundak
authors.forename: Nurçin
authors.initials: N
authors.lastname: Saka
authors.forename: Tülin
authors.initials: T
authors.lastname: Özden
authors.forename: Feyza
authors.initials: F
authors.lastname: Darendeliler
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005320:Fetal Macrosomia / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology*; D063766:Pediatric Obesity / Q000150:complications / Q000453:epidemiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology / Q000378:metabolism*; D012307:Risk Factors
keywords: atherogenic index; dyslipidemia; large for gestational age; metabolic syndrome