title: Alterations of penicillin-binding proteins in pneumococci with stepwise increase in β-lactam resistance.
abstract: Infection caused by Streptococcus pneumoniae has become increasingly complicated and costly to treat due to the increase in β-lactam resistance. A total of 80 pneumococcal isolates with stepwise increase in penicillin and ceftriaxone resistance were analyzed for the sequential changes in their penicillin-binding proteins (PBPs) 1a, 2b, and 2x. The result provides an insight into the evolution of PBPs associated with β-lactam resistance in a natural population of S. pneumoniae.
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
authors.forename: Yu-Chia
authors.initials: YC
authors.lastname: Hsieh
authors.forename: Lin-Hui
authors.initials: LH
authors.lastname: Su
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Hsu
authors.forename: Cheng-Hsun
authors.initials: CH
authors.lastname: Chiu
mesh_terms: D019943:Amino Acid Substitution; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology; D004252:DNA Mutational Analysis; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D006801:Humans; D046915:Penicillin-Binding Proteins / Q000235:genetics*; D010406:Penicillins / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics*; D018440:beta-Lactam Resistance; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D046915:Penicillin-Binding Proteins; D010406:Penicillins; D047090:beta-Lactams; D002443:Ceftriaxone