title: Organocatalytic Michael addition of indoles to isatylidene-3-acetaldehydes: application to the formal total synthesis of (-)-chimonanthine.
abstract: A novel strategy for the enantioselective synthesis of 3,3'-disubstituted oxindoles by the organocatalytic Michael addition of indoles to isatylidene-3-acetaldehydes was developed, which can be used for the formal total synthesis of (-)-chimonanthine and the core structure construction of (+)-gliocladin C.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, PR China.
authors.forename: Renrong
authors.initials: R
authors.lastname: Liu
authors.forename: Junliang
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000079:Acetaldehyde / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D000078183:Oxindoles; D010879:Piperazines / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D011760:Pyrrolidinones / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D000078183:Oxindoles; D010879:Piperazines; D011758:Pyrroles; D011760:Pyrrolidinones; C518056:gliocladin C; C022960:2-oxindole; C521484:chimonanthine; D000079:Acetaldehyde