title: Body mass index and weight change during adulthood are associated with increased mortality from liver cancer: the JACC Study.
abstract: BACKGROUND
  We investigated the association of baseline body mass index (BMI) and weight change since age 20 years with liver cancer mortality among Japanese.
  
  
  METHODS
  The data were obtained from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). A total of 31 018 Japanese men and 41 455 Japanese women aged 40 to 79 years who had no history of cancer were followed from 1988 through 2009.
  
  
  RESULTS
  During a median 19-year follow-up, 527 deaths from liver cancer (338 men, 189 women) were documented. There was no association between baseline BMI and liver cancer mortality among men or men with history of liver disease. Men without history of liver disease had multivariable hazard ratios (HR) of 1.95 (95%CI, 1.07-3.54) for BMI less than 18.5 kg/m(2) and 1.65 (1.05-2.60) for BMI of 25 kg/m(2) or higher, as compared with a BMI of 21.0 to 22.9 kg/m(2). BMI was positively associated with liver cancer mortality among women and women with history of liver disease. Weight change since age 20 years was positively associated with liver cancer mortality among women regardless of history of liver disease. Women with history of liver disease had a multivariable HRs of 1.96 (1.05-3.66) for weight gain of 5.0 to 9.9 kg and 2.31 (1.18-4.49) for weight gain of 10 kg or more, as compared with weight change of -4.9 to 4.9 kg.
  
  
  CONCLUSIONS
  Both underweight (BMI <18.5 kg/m(2)) and overweight (BMI ≥25 kg/m(2)) among men without history of liver disease, and weight gain after age 20 (weight change ≥5 kg) among women with history of liver disease, were associated with increased mortality from liver cancer.
authors.affiliation: Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Yuanying
authors.initials: Y
authors.lastname: Li
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yatsuya
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yamagishi
authors.forename: Kenji
authors.initials: K
authors.lastname: Wakai
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Mori
authors.forename: Fumio
authors.initials: F
authors.lastname: Sakauchi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Motohashi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tsuji
authors.forename: Yosikazu
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Haruo
authors.initials: H
authors.lastname: Mikami
authors.forename: Michiko
authors.initials: M
authors.lastname: Kurosawa
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Hoshiyama
authors.forename: Naohito
authors.initials: N
authors.lastname: Tanabe
authors.forename: Koji
authors.initials: K
authors.lastname: Tamakoshi
authors.forename: Shinkan
authors.initials: S
authors.lastname: Tokudome
authors.forename: Koji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Shuji
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Shogo
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Wada
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawamura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Kotaro
authors.initials: K
authors.lastname: Ozasa
authors.forename: Tsuneharu
authors.initials: T
authors.lastname: Miki
authors.forename: Chigusa
authors.initials: C
authors.lastname: Date
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Sakata
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kurozawa
authors.forename: Takesumi
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Fujino
authors.forename: Akira
authors.initials: A
authors.lastname: Shibata
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Okamoto
authors.forename: Hideo
authors.initials: H
authors.lastname: Shio
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008113:Liver Neoplasms / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015430:Weight Gain; D015431:Weight Loss; D055815:Young Adult