title: Long-term management of a patient with well-differentiated pulmonary neuroendocrine carcinoma: a case report.
abstract: Pulmonary neuroendocrine tumors (NET) are rare, and very few published reports have described the long-term treatment of patients with this disease. Current treatment options for patients with metastatic well-differentiated pulmonary NET are limited. This case report details the long-term treatment of a 62-year-old female patient with well-differentiated pulmonary NET and multiple liver metastases. The heavily pretreated patient achieved radiographic stability in measurable disease, improvement in nonmeasurable disease, and symptomatic improvement over 3 years while receiving the combination of everolimus and octreotide long-acting repeatable (LAR). Treatment was well tolerated without mucositis, rash, or pneumonitis. This case report suggests that the combination of everolimus and octreotide LAR may be a novel treatment option for heavily pretreated patients with metastatic well-differentiated pulmonary NET, but these findings require further analysis in clinical trials.
authors.affiliation: Highlands Oncology Group, Rogers, Ark., USA.
authors.forename: Thaddeus
authors.initials: T
authors.lastname: Beck
authors.forename: Ryan
authors.initials: R
authors.lastname: Mantooth
keywords: Everolimus; Neuroendocrine tumors; Octreotide long-acting repeatable; Pulmonary neuroendocrine tumors; Well-differentiated pulmonary neuroendocrine tumors