title: Secondary membranous nephropathy associated with guillain-barré syndrome.
abstract: Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome (NS) in adults. It may be primary, usually mediated by IgG4 anti-phospholipase A2 autoantibodies or secondary to various other conditions. Guillain- Barré syndrome (GBS) has been associated with MN, but a cause and effect relation has not been proven. We present a case of concurrent development of GBS and severe NS, with renal biopsy demonstrating MN. IgG4 stain was negative, indicating that most likely, the MN was secondary and probably caused by the underlying GBS.
authors.affiliation: Department of Medicine, Thomas Jefferson University, Philadelphia, Pa., USA ; Division of Nephrology, Thomas Jefferson University, Philadelphia, Pa., USA.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Filippone
authors.forename: Mitul
authors.initials: M
authors.lastname: Kanzaria
authors.forename: Rodney
authors.initials: R
authors.lastname: Bell
authors.forename: Eric
authors.initials: E
authors.lastname: Newman
authors.forename: John
authors.initials: J
authors.lastname: L Farber
keywords: Guillain-Barré syndrome; Membranous nephropathy; Nephrotic syndrome