title: The role of methyl-CpG binding protein 2 in liver fibrosis.
abstract: Liver injury is induced by various insults such as alcohol abuse, if insults persist, may result in the formation of liver fibrosis. Hepatic stellate cell (HSC) activation and transdifferentiation into hepatic myofibroblast, accompanied with potent pro-inflammatory and pro-fibrogenic activities and the down-regulation of anti-inflammatory anti-fibrogenic in gene expression in coordination with epigenetic modifications at the level of the chromatin structure, are pivotal events in liver fibrogenesis. In this review we focus on the role of the methyl-CpG binding protein 2 (MeCP2) transcriptional regulation of different target genes and the interaction MeCP2 with microRNAs (miRNAs) during liver fibrosis. In addition, we address different signaling pathways interacted with MeCP2 regulated HSC activation. Such approaches provide valuable insights into the potential targets of liver fibrosis, and are useful pointers for the development of future therapeutic strategies.
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei 230032, China.
authors.forename: Er-Bao
authors.initials: EB
authors.lastname: Bian
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Tao
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiong-wen
authors.initials: XW
authors.lastname: Lv
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051783:Methyl-CpG-Binding Protein 2 / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D051783:Methyl-CpG-Binding Protein 2