title: Optimal indication of thyroglobulin measurement in fine-needle aspiration for detecting lateral metastatic lymph nodes in patients with papillary thyroid carcinoma.
abstract: BACKGROUND
  The purpose of this study was to evaluate optimal indication of thyroglobulin (Tg) measurement in fine-needle aspiration (FNA) for detecting lateral metastatic lymph nodes in patients with papillary thyroid carcinoma (PTC).
  
  
  METHODS
  We performed a retrospective study of 241 lymph nodes of 220 patients who underwent ultrasound-guided FNA with Tg in FNA (FNA-Tg) washout fluid measurements for suspicious lymph nodes.
  
  
  RESULTS
  On multivariate analysis, hyperechogenicity, cystic change, presence of calcifications, and peripheral vascularity were independent factors predictive of lymph node metastasis. After adding FNA-Tg, sensitivity and accuracy were significantly increased when the lymph node had 1 or 2 suspicious ultrasound features. However, sensitivity and accuracy were not significantly increased when the lymph node had multiple suspicious ultrasound features.
  
  
  CONCLUSIONS
  Additional FNA-Tg can help diagnose a metastatic lymph node with 1 or 2 suspicious ultrasound features. However, additional FNA-Tg is not beneficial in lymph nodes with highly suspicious ultrasound features, in which FNA alone is sufficient for diagnosis of predictive of lymph node.
authors.affiliation: Department of Radiology, Ewha Womans University, School of Medicine, Seoul, Korea.
authors.forename: Jin
authors.initials: J
authors.lastname: Chung
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Kim
authors.forename: Hyunsun
authors.initials: H
authors.lastname: Lim
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Son
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Yoon
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Youk
authors.forename: Jeong-Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Moon
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Kwak
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D044963:Biopsy, Fine-Needle; D002277:Carcinoma / Q000097:blood / Q000473:pathology* / Q000556:secondary*; D002291:Carcinoma, Papillary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013954:Thyroglobulin / Q000097:blood*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000097:blood / Q000473:pathology* / Q000556:secondary*
chemical_list: D015415:Biomarkers; D013954:Thyroglobulin
keywords: fine-needle aspiration; lymph node metastasis; papillary thyroid carcinoma; thyroglobulin; ultrasound