title: [Organ-sparing surgery for nephroblastoma in children].
abstract: We present the results of 53 stage I-III nephroblastoma pediatric patients treated in Belarusia from 2005 to 2010. All the patients received adjuvant chemotherapy (according to SIOP WT 2001 protocol), surgery (complete or partial nephrectomy) and neoadjuvant chemotherapy. The prolonged adjuvant chemotherapy was proposed in patients with good response as a cytoreductive measure enabling organ-sparing surgery. Five-year event-free survival was 91+/-6% in complete and 89+/-9% in partial nephrectomy recipients (p=0,64). Our experience suggest the feasibility of prolonged adjuvant chemoradiotherapy in patients with good clinical response and no contraindications for complete nephrectomy.
authors.forename: R S
authors.initials: RS
authors.lastname: Ismail-zade
authors.forename: D V
authors.initials: DV
authors.lastname: Kochubinskiĭ
authors.forename: A T
authors.initials: AT
authors.lastname: Shimanskiĭ
authors.forename: S I
authors.initials: SI
authors.lastname: Nazaruk
authors.forename: E A
authors.initials: EA
authors.lastname: Rutskaia
authors.forename: I V
authors.initials: IV
authors.lastname: Begin
authors.forename: A S
authors.initials: AS
authors.lastname: Fedorova
authors.forename: N N
authors.initials: NN
authors.lastname: Savva
authors.forename: O I
authors.initials: OI
authors.lastname: Vydanov
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D020360:Neoadjuvant Therapy / Q000379:methods*; D009367:Neoplasm Staging; D009392:Nephrectomy / Q000379:methods*; D002094:Republic of Belarus; D016896:Treatment Outcome; D009396:Wilms Tumor / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery*