title: Reciprocating sliding wear behavior of alendronate sodium-loaded UHMWPE under different tribological conditions.
abstract: The aim of this study is to investigate the tribological behaviors and wear mechanisms of ultra-high molecular weight polyethylene (UHMWPE) loaded with alendronate sodium (ALN), a potential drug to treat osteolysis, under different normal loads and lubrication conditions. A mixture of UHMWPE powder and ALN (1.0 wt.%) solution was dried and hot pressed. The static and dynamic friction coefficients of UHMWPE-ALN were slightly higher than those of UHMWPE except under normal load as 10 N and in 25 v/v % calf serum. The specific wear rates of UHMWPE-ALN and UHMWPE were the lowest in 25 v/v % calf serum compared to those in deionized water or physiological saline. In particular, the specific wear rate of UHMWPE-ALN was lower than that of UHMWPE at 50 N in 25 v/v % calf serum. The main wear mechanisms of UHMWPE and UHMWPE-ALN in deionized water and UHMWPE in physiological saline were abrasive. The main wear mechanism of UHMWPE-ALN in physiological saline was micro-fatigue. In 25 v/v % calf serum, the main wear mechanism of UHMWPE and UHMWPE-ALN was abrasive wear accompanied with plastic deformation. The results of Micro-XRD indicated that the molecular deformation of UHMWPE-ALN and UHMWPE under the lower stress were in the amorphous region but in the crystalline region at the higher stress. These results showed that the wear of UHMWPE-ALN would be reduced under calf serum lubricated, which would be potentially applied to treat osteolysis.
authors.affiliation: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031,China.
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.forename: Shuxin
authors.initials: S
authors.lastname: Qu
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.forename: Ke
authors.initials: K
authors.lastname: Duan
authors.forename: Jie
authors.initials: J
authors.lastname: Weng
mesh_terms: D019386:Alendronate / Q000737:chemistry*; D001672:Biocompatible Materials; D007595:Joint Prosthesis; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011095:Polyethylenes / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene; D019386:Alendronate