title: [Correction of hepatic dysfunction as pre-treatment before systemic chemotherapy in patients with bile duct neoplasms].
abstract: This prospective randomized study incorporates 141 surgical department patients with hepatobiliary tumors. The 1st group patients received 800 ml/day of remaxol. The 2nd1 group patients received Ringer solution and 10% glucose at 1:1 ratio. The subgroups included: 1 subgroup-with pre-operative cholecysto- or choledochostomia and B-subgroup-without pre-operative interventions. The combined surgical and pharmaceutical correction of bile passage, bilirubinemia, cholestasis and cytolysis by remaxole leads to better hepatic dysfunction correction and allows better timing of chemotherapy in bile passage tumors.
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Iakovlev
authors.forename: A S
authors.initials: AS
authors.lastname: Chichkanova
authors.forename: D N
authors.initials: DN
authors.lastname: Ulitin
authors.forename: K V
authors.initials: KV
authors.lastname: Mokrov
authors.forename: S V
authors.initials: SV
authors.lastname: Akulenko
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001650:Bile Duct Neoplasms / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic / Q000187:drug effects / Q000503:physiopathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002767:Cholecystostomy; D002768:Choledochostomy; D002779:Cholestasis / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000188:drug therapy / Q000601:surgery; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020011:Protective Agents / Q000627:therapeutic use; D013386:Succinates / Q000627:therapeutic use*
chemical_list: D020011:Protective Agents; C555877:Remaxol; D013386:Succinates