title: Kidney cancer and diabetes mellitus: a population-based case-control study in Taiwan.
abstract: BACKGROUND
  The purpose of this study was to explore whether diabetes mellitus (DM) correlates with the risk of kidney cancer in Taiwan.
  
  
  METHODS
  We designed a population-based case-control study from the Taiwan National Health Insurance Database, which consisted of 116 patients with newly diagnosed kidney cancer as cases and 464 subjects without kidney cancer as controls in 2000 to 2009. Both cases and controls were aged ≥20 years. Baseline comorbidities were compared between kidney cancer cases and controls.
  
  
  RESULTS
  Multivariable analysis showed no association was detected between DM and kidney cancer (OR 1.06, 95% CI, 0.58 to 1.94). Hypertension (OR 2.05, 95% CI, 1.23 to 3.42), chronic kidney diseases (OR 2.57, 95% CI, 1.23 to 5.37), cystic kidney diseases (OR 18.6, 95% CI, 1.84 to 187.6) and kidney stones (OR 4.02, 95% CI, 2.43 to 6.66) were significant comorbidities associated with increased risk of kidney cancer. Use of alpha-glucosidase inhibitor was associated with increased risk of kidney cancer (OR 4.31, 95% CI, 1.07 to 17.3).
  
  
  CONCLUSIONS
  DM does not correlate with the risk of kidney cancer. Hypertension, chronic kidney diseases, cystic kidney diseases, kidney stones and use of alpha-glucosidase inhibitors are associated with kidney cancer.
authors.affiliation: School of Medicine, China Medical University, Taichung, 404, Taiwan.
authors.forename: Shih Wei
authors.initials: SW
authors.lastname: Lai
authors.forename: Kuan Fu
authors.initials: KF
authors.lastname: Liao
authors.forename: Hsueh Chou
authors.initials: HC
authors.lastname: Lai
authors.forename: Pang Yao
authors.initials: PY
authors.lastname: Tsai
authors.forename: Fung Chang
authors.initials: FC
authors.lastname: Sung
authors.forename: Pei Chun
authors.initials: PC
authors.lastname: Chen
mesh_terms: D002292:Carcinoma, Renal Cell / Q000209:etiology*; D016022:Case-Control Studies; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D007004:Hypoglycemic Agents