title: Expression of the novel all-trans retinoic acid-related resistance gene HA117 in pediatric solid tumors.
abstract: This study aimed to detect the protein expression of HA117 in pediatric solid tumors. Immunohistochemistry was performed to detect the expression of HA117 and P-gp in pediatric solid tumors. In Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), nephroblastoma (WT), and neuroblastoma (NB), the positive expression rate of HA117 was 65.4%, 58.3%, 81.3%, and 74.1%, and that of P-gp was 57.7%, 70.8%, 65.6%, and 66.7%, respectively. HA117 expression was closely related to the clinical stage of HL (P=0.004) and to the International Prognostic Index score, mediastinal lesions, and clinical stages of NHL (P=0.01, 0.03, and 0.01). The expression of HA117 in WT was higher than in adjacent normal tissues, but there was no statistical significance (P=0.21). The positive expression of HA117 in NB was markedly higher than that in normal tissues (P=0.002), which closely associated with histologic type and lymph node metastasis (P=0.03 and 0.001). Spearman correlation analysis revealed that HA117 expression was not correlated with P-gp in these 4 tumors. This suggests that HA117 might be an important resistance gene in pediatric solid tumors. The mechanism underlying the resistance to all-trans retinoic acid conferred by HA117 is different from that of P-gp.
authors.affiliation: *Laboratory of Oncology Departments of †Surgery ¶Hematology #Pathology ‡Ministry of Education Key Laboratory of Child Development and Disorders §Key Laboratory of Pediatrics in Chongqing ∥Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Affiliated Children's Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Duan
authors.forename: Xianqing
authors.initials: X
authors.lastname: Jin
authors.forename: Youhua
authors.initials: Y
authors.lastname: Xiu
authors.forename: Shiqi
authors.initials: S
authors.lastname: Wang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
authors.forename: Hang
authors.initials: H
authors.lastname: Liu
authors.forename: Xionghui
authors.initials: X
authors.lastname: Ding
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
authors.forename: Zhanbo
authors.initials: Z
authors.lastname: Zhao
authors.forename: Xiuliang
authors.initials: X
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D018432:Drug Resistance, Multiple / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000235:genetics; D008297:Male; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D009423:Nervous System Neoplasms / Q000188:drug therapy / Q000235:genetics; D009447:Neuroblastoma / Q000188:drug therapy / Q000235:genetics; D014212:Tretinoin / Q000627:therapeutic use*; D009396:Wilms Tumor / Q000188:drug therapy / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009363:Neoplasm Proteins; D014212:Tretinoin; C586650:HA117 protein, human