title: Prophylactic total thyroidectomy using the minimally invasive video-assisted approach in children with multiple endocrine neoplasia type 2.
abstract: BACKGROUND
  There have been few reports of prophylactic thyroidectomy using the minimally invasive video-assisted thyroidectomy (MIVAT) approach in children with multiple endocrine neoplasia 2 (MEN2).
  
  
  METHODS
  We conducted a retrospective review of a prospectively maintained database of patients who underwent MIVAT for total thyroidectomy.
  
  
  RESULTS
  Six children underwent MIVAT; RET codon mutations identified were 634, 620, 611, and 918. Mean operative time was 93 minutes (range, 68-105 minutes). Five patients were discharged on the first postoperative day; however, 1 patient had a postoperative hematoma and was discharged 2 days postoperatively. There were no cases of laryngeal nerve palsy or postoperative hypoparathyroidism. High levels of satisfaction with postoperative cosmesis were reported. Calcitonin levels have been undetectable at follow-up thus far (mean follow-up, 42.8 months).
  
  
  CONCLUSIONS
  Although our outcomes are similar to those reported using the traditional approach, it is important to note that MIVAT is essentially the same operation, just performed through a smaller incision, with resulting benefits in terms of pain, cosmesis and, perhaps, morbidity.
authors.affiliation: Department of Otorhinolaryngology, Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin, Republic of Ireland.
authors.forename: Ronan W
authors.initials: RW
authors.lastname: Glynn
authors.forename: Emma C
authors.initials: EC
authors.lastname: Cashman
authors.forename: Jaime
authors.initials: J
authors.lastname: Doody
authors.forename: Eimear
authors.initials: E
authors.lastname: Phelan
authors.forename: John D
authors.initials: JD
authors.lastname: Russell
authors.forename: Conrad
authors.initials: C
authors.lastname: Timon
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003062:Codon; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006406:Hematoma / Q000209:etiology; D006801:Humans; D008297:Male; D018813:Multiple Endocrine Neoplasia Type 2a / Q000235:genetics* / Q000601:surgery*; D009154:Mutation; D061646:Operative Time; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000235:genetics / Q000517:prevention & control* / Q000601:surgery*; D013965:Thyroidectomy / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome; D014481:United States; D020535:Video-Assisted Surgery / Q000379:methods
chemical_list: D015415:Biomarkers; D003062:Codon; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human
keywords: MEN2; MIVAT; RET; medullary thyroid cancer