title: Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: a meta-analysis of adjusted observational results.
abstract: OBJECTIVE
  Coronary artery disease (CAD) negatively affects prognosis in patients undergoing surgical aortic valve replacement, being currently evaluated in the most common used risk score. Our meta-analysis aims to clarify the prognostic role of CAD on mid-term survival in patients undergoing TAVI.
  
  
  RESULTS
  Studies reporting multivariate predictors of adverse outcomes in patients undergoing TAVI were systematically searched for and pooled, when appropriate, using a random-effect method. 960 citations were first screened and finally 7 studies (2472 patients) were included. Diagnosis of CAD was reported in 52%(42-65) of patients and 1169 Edwards SAPIEN and 1303 CoreValve prostheses were implanted. After a median follow up of 452 days (357-585) 24% of patients (19-33) died, and 23 (14-32) for cardiovascular death. At pooled analysis of multivariate approach, diagnosis of coronary artery disease did not increase risk of death (OR 1.0, 95% CI, confidence interval, 0.67-1.50 I(2) 0%).
  
  
  CONCLUSIONS
  CAD does not affect mid-term TAVI outcome: this finding should be weighted to accurately evaluate risk and strategies for patients with severe aortic stenosis.
authors.affiliation: Division of Cardiology, University of Turin, Italy; Meta-analysis and Evidence based medicine Training in Cardiology (METCARDIO), Italy. Electronic address: fabrizio.dascenzo@gmail.com.
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authors.lastname: Schnabel
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authors.lastname: Seiffert
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authors.lastname: Wilde
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authors.lastname: Gasparetto
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authors.lastname: Napodano
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authors.lastname: Presbitero
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authors.lastname: Rossi
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authors.lastname: Gasparini
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authors.lastname: Biondi Zoccai
authors.forename: M
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authors.lastname: Lupo
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authors.lastname: Rinaldi
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authors.lastname: Gaita
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mesh_terms: D001024:Aortic Valve Stenosis / Q000150:complications* / Q000601:surgery*; D003324:Coronary Artery Disease / Q000150:complications*; D006801:Humans; D064887:Observational Studies as Topic; D011379:Prognosis; D013997:Time Factors; D065467:Transcatheter Aortic Valve Replacement
keywords: CAD; Mid-term outcomes; TAVI