title: A low-grade increase of serum pancreatic exocrine enzyme levels by dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes.
abstract: A potential adverse effect of dipeptidyl peptidase-4 inhibitors (DPP-4i) on the pancreas remains controversial. We evaluated the DPP-4i effects on pancreatic amylase and lipase activity in patients with type 2 diabetes. These enzymes were slightly but significantly increased, suggesting DPP-4i cause a low-grade inflammatory change in the exocrine pancreas.
authors.affiliation: Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. hiroppy_hiroppy@yahoo.co.jp
authors.forename: Hirotake
authors.initials: H
authors.lastname: Tokuyama
authors.forename: Harukiyo
authors.initials: H
authors.lastname: Kawamura
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Kazuki
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Mie
authors.initials: M
authors.lastname: Nieda
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Okazawa
authors.forename: Minoru
authors.initials: M
authors.lastname: Takemoto
authors.forename: Fumio
authors.initials: F
authors.lastname: Shimada
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008049:Lipase / Q000097:blood; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology; D055292:Pancreatic alpha-Amylases / Q000097:blood; D010195:Pancreatitis / Q000097:blood; D012189:Retrospective Studies
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D008049:Lipase; D055292:Pancreatic alpha-Amylases