title: Helical oligomers of thiazole-based γ-amino acids: synthesis and structural studies.
abstract: 9-Helix: 4-Amino(methyl)-1,3-thiazole-5-carboxylic acids (ATCs) were synthesized as new γ-amino acid building blocks. The structures of various ATC oligomers were analyzed in solution by CD and NMR spectroscopy and in the solid state by X-ray crystallography. The ATC sequences adopted a well-defined 9-helix structure in the solid state and in aprotic and protic organic solvents as well as in aqueous solution.
authors.affiliation: Institut des Biomolécules Max Mousseron, UMR 5247, CNRS, Universités Montpellier I et II, UFR des Sciences Pharmaceutiques et Biologiques, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France.
authors.forename: Loïc
authors.initials: L
authors.lastname: Mathieu
authors.forename: Baptiste
authors.initials: B
authors.lastname: Legrand
authors.forename: Cheng
authors.initials: C
authors.lastname: Deng
authors.forename: Lubomir
authors.initials: L
authors.lastname: Vezenkov
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Wenger
authors.forename: Claude
authors.initials: C
authors.lastname: Didierjean
authors.forename: Muriel
authors.initials: M
authors.lastname: Amblard
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Averlant-Petit
authors.forename: Nicolas
authors.initials: N
authors.lastname: Masurier
authors.forename: Vincent
authors.initials: V
authors.lastname: Lisowski
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.forename: Ludovic T
authors.initials: LT
authors.lastname: Maillard
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002942:Circular Dichroism; D008958:Models, Molecular; D011108:Polymers / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D011108:Polymers; D013844:Thiazoles