title: The effect of levobupivacaine and bupivacaine on QT, corrected QT (Qtc), and P wave dispersions in cesarean section.
abstract: OBJECTIVE
  In our study we aimed to investigate the effect of bupivacaine and levobupivacaine on QT, corrected QT (QTc), and P wave dispersion durations during spinal anesthesia in cesarean section.
  
  
  METHODS
  Sixty parturients scheduled for elective cesarean section in ASA I-II risk groups were included in the study. Baseline electrocardiographic (ECG) records of the patients were obtained in the operation room. Heart rate (HR), non-invasive blood pressure (NIBP), peripheral oxygen saturation (SpO2) and respiration rates (RR) were recorded. Venous cannulation was performed with 18G cannula and fl uid preload made with 10mL.kg(-1). Lactated Ringer solution. After fl uid preload, second ECG recordings were taken and the patients were randomly separated into two groups. Group B (n=30) received 10mg of bupivacaine and Group L (n=30) received 10mg of levobupivacaine for spinal anesthesia. ECG recordings were repeated at 1, 5 and 10minutes after spinal block. HR, NIBP, SpO2 , RR and sensory block levels were also recorded at the same time intervals. At predetermined time intervals of spinal anesthesia, P wave dispersion (Pwd), QT dispersion (QTd), and QTc dispersion (QTcd) durations were measured from ECG records. QT and QTc durations are calculated with Bazzett formula.
authors.affiliation: Karaelmas University, School of Medicine, Department of Anaesthesiology and Reanimation, Zonguldak, Turkey.
authors.forename: Yeliz
authors.initials: Y
authors.lastname: Deniz
authors.forename: Dilek
authors.initials: D
authors.lastname: Okyay
authors.forename: Volkan
authors.initials: V
authors.lastname: Hancı
authors.forename: Serhan
authors.initials: S
authors.lastname: Yurtlu
authors.forename: Hilal
authors.initials: H
authors.lastname: Ayoğlu
authors.forename: Işıl
authors.initials: I
authors.lastname: Ozkocak Turan
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D000779:Anesthetics, Local / Q000494:pharmacology*; D002045:Bupivacaine / Q000031:analogs & derivatives / Q000494:pharmacology*; D002585:Cesarean Section; D004311:Double-Blind Method; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006801:Humans; D000077554:Levobupivacaine; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D000779:Anesthetics, Local; D000077554:Levobupivacaine; D002045:Bupivacaine