title: Polymorphisms in schizophrenia candidate gene UFD1L may contribute to cognitive deficits.
abstract: We aimed to investigate UFD1L polymorphisms in schizophrenia and in relation to cognition. A total of 299 cases and 363 controls were genotyped, and 130 patients completed nine neuropsychological tests. We found that rs5992403 AA-genotype carriers showed lower scores on the set-shifting task. Therefore, UFD1L may participate in the core cognitive deficits observed in schizophrenia.
authors.affiliation: Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo (UNIFESP), Rua Botucatu 740, Edifício Leitao da Cunha, 1° Andar, CEP 04023-900 Sao Paulo, Brazil. vanessakaota@gmail.com
authors.forename: Vanessa K
authors.initials: VK
authors.lastname: Ota
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Berberian
authors.forename: Ary
authors.initials: A
authors.lastname: Gadelha
authors.forename: Marcos L
authors.initials: ML
authors.lastname: Santoro
authors.forename: Gustavo L
authors.initials: GL
authors.lastname: Ottoni
authors.forename: Camila T
authors.initials: CT
authors.lastname: Matsuzaka
authors.forename: Jair J
authors.initials: JJ
authors.lastname: Mari
authors.forename: Maria I
authors.initials: MI
authors.lastname: Melaragno
authors.forename: Diogo R
authors.initials: DR
authors.lastname: Lara
authors.forename: Marília A C
authors.initials: MA
authors.lastname: Smith
authors.forename: Sintia I
authors.initials: SI
authors.lastname: Belangero
authors.forename: Rodrigo A
authors.initials: RA
authors.lastname: Bressan
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport; D000328:Adult; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D003072:Cognition Disorders / Q000209:etiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007266:Inhibition, Psychological; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000150:complications / Q000235:genetics*; D014706:Verbal Learning
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; C491497:UFD1 protein, human
keywords: Cognition; Executive functions; Gene