title: Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain.
abstract: We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background.
authors.affiliation: The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom. er1@sanger.ac.uk
authors.forename: Edward
authors.initials: E
authors.lastname: Ryder
authors.forename: Kim
authors.initials: K
authors.lastname: Wong
authors.forename: Diane
authors.initials: D
authors.lastname: Gleeson
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Keane
authors.forename: Debarati
authors.initials: D
authors.lastname: Sethi
authors.forename: Sapna
authors.initials: S
authors.lastname: Vyas
authors.forename: Hannah
authors.initials: H
authors.lastname: Wardle-Jones
authors.forename: James N
authors.initials: JN
authors.lastname: Bussell
authors.forename: Richard
authors.initials: R
authors.lastname: Houghton
authors.forename: Jennifer
authors.initials: J
authors.lastname: Salisbury
authors.forename: Nina
authors.initials: N
authors.lastname: Harvey
authors.forename: David J
authors.initials: DJ
authors.lastname: Adams
authors.forename: Ramiro
authors.initials: R
authors.lastname: Ramirez-Solis
mesh_terms: D000417:Albinism / Q000235:genetics; D000818:Animals; D016678:Genome; D023281:Genomics; D005838:Genotype; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008822:Mice, Transgenic; D014442:Monophenol Monooxygenase / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism; D017422:Sequence Analysis, DNA
chemical_list: D014442:Monophenol Monooxygenase
keywords: genetics; genome sequencing; genomics; mammalian; mouse; transgenics