title: [Anticarcinogenic effect of potassium salts of glucaric and glucuronic acid in induced models of cervical and esophageal tumors].
abstract: This study compares the anti-carcinogenic activity of calcium glucarate, potassium glucarate, and potassium glucuronate in cervix and esophagus induced cancer murine models. The cervical cancer induction was performed by tampons moistened with 0.1% solution of 7,12-dimethylbenz(a) anthracene (DMBA) applied intravaginally twice a week for 6 weeks in mice. Esophageal cancer was induced by oral administration of 10 mg of N-methyl-N-benzylnitrosoamine (MBNA) with drinking water for 1 month in rats. The 2 g per kilo of studied substances was administered orally with food immediately after the exposure to cancerogens for the period of 11 months. Compared to the control group the calcium glucarate, potassium glucarate and potassium glucuronate introduction reduced the incidence of cervical cancers by 20.4%, 32.1%, and 30.0% (p<0.05), accordingly; calcium glucarate introduction decreased only the medium number of the esophagus tumors by 44.3% (p<0.05); potassium glucarate and potassium glucuronate reduced the incidence of esophagus tumors by 35.1% and 61.3% (p<0.05) and their number by 32% and 58.5% (p<0.05), accordingly. Compared with calcium glucarate, potassium salts of glucaric and glucuronic acids inhibit cervical and esophageal carcinogenesis more effectively.
authors.forename: V G
authors.initials: VG
authors.lastname: Bespalov
authors.forename: V A
authors.initials: VA
authors.lastname: Aleksandrov
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D017610:Calcium Compounds / Q000494:pharmacology; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives; D004195:Disease Models, Animal; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D005937:Glucaric Acid / Q000008:administration & dosage / Q000494:pharmacology*; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D017680:Potassium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D012492:Salts / Q000494:pharmacology; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D016588:Anticarcinogenic Agents; D017610:Calcium Compounds; D002273:Carcinogens; D017680:Potassium Compounds; D012492:Salts; D015127:9,10-Dimethyl-1,2-benzanthracene; D020723:Glucuronic Acid; C014707:nitrosobenzylmethylamine; D004128:Dimethylnitrosamine; D005937:Glucaric Acid