title: Effects of aluminum chloride on some trace elements and erythrocyte osmotic fragility in rats.
abstract: Aluminum (Al) is a nonessential, toxic element to which humans are constantly exposed as a result of an increase in industrialization and improving technology practices. The aim of the study was to investigate the effects of different durations and doses of Al exposure on serum and tissue element levels and erythrocyte osmotic fragility in rats. A total of 40 male Wistar Albino rats were divided into five groups: control, group I (3 weeks, 8 mg/kg), group II (6 weeks, 8 mg/kg), group III (3 weeks, 16 mg/kg), and group IV (6 weeks, 16 mg/kg). Al chloride (AlCl3) was injected intraperitoneally (i.p.) five times a week. At the end of the experimental period, levels of Al, iron (Fe), copper (Cu), and zinc (Zn) in serum, liver, and kidney tissues were measured using inductively coupled plasma optical emission spectrometry. Osmotic fragility was determined using a spectrophotometer. The results of the experiment indicate that Al induced a statistically significant increase in Al and Fe concentrations in liver and serum as well as in Cu in the kidney. The Fe concentration in serum and kidney tissues was significantly lower in all the groups. As a result of our study, it may be concluded that tissue Al accumulation may lead to an increase in osmotic fragility of erythrocytes and abnormal trace element levels.
authors.affiliation: Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Oztürk
authors.affiliation: Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey hsf@istanbul.edu.tr.
authors.forename: Semra
authors.initials: S
authors.lastname: Ozdemir
mesh_terms: D000535:Aluminum / Q000097:blood / Q000378:metabolism / Q000633:toxicity*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000008:administration & dosage; D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D000818:Animals; D002712:Chlorides / Q000008:administration & dosage; D003300:Copper / Q000097:blood / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D007501:Iron / Q000097:blood / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009996:Osmotic Fragility / Q000187:drug effects*; D017208:Rats, Wistar; D013054:Spectrophotometry, Atomic; D013997:Time Factors; D014018:Tissue Distribution; D066007:Toxicokinetics; D014131:Trace Elements / Q000037:antagonists & inhibitors* / Q000172:deficiency; D015032:Zinc / Q000097:blood / Q000378:metabolism
chemical_list: D017607:Aluminum Compounds; D002712:Chlorides; D004785:Environmental Pollutants; D014131:Trace Elements; D000077410:Aluminum Chloride; D003300:Copper; D000535:Aluminum; D007501:Iron; D015032:Zinc
keywords: Aluminum; ICP-OES; osmotic fragility; rat; trace element