title: [The membrane stabilizing effect of glatiramer acetate in multiple sclerosis].
abstract: The effect of glatiramer acetate on the structure of the lipid phase of cell membranes of red blood cells, the status of lipid peroxidation and antioxidant defense system in patients with relapsing forms of multiple sclerosis. It is shown that during treatment with glatiramer acetate reduces the initially high, level of phospholipase A2, and the concentration of lipid peroxidation products - diene conjugates and Schiff bases. At the same time against the increase initially reduced activity of the antioxidant defense normal structure of erythrocyte membranes in patients with relapsing-remitting multiple sclerosis. Based on the analysis of the dynamics of laboratory parameters proved membranoprotektiv effect the drug.
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Kravtsov
authors.forename: O A
authors.initials: OA
authors.lastname: Kicherova
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D000068717:Glatiramer Acetate; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000378:metabolism; D010455:Peptides / Q000008:administration & dosage / Q000627:therapeutic use*; D064801:Phospholipase A2 Inhibitors; D054467:Phospholipases A2 / Q000378:metabolism; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000276:Adjuvants, Immunologic; D010455:Peptides; D064801:Phospholipase A2 Inhibitors; D000068717:Glatiramer Acetate; D054467:Phospholipases A2