title: The metabolic inter-relationships between changes in waist circumference, triglycerides, insulin sensitivity and small, dense low-density lipoprotein particles with acute weight loss in clinically obese children and adolescents.
abstract: OBJECTIVE
  Small, dense low-density lipoprotein (LDL) particles are highly atherogenic and strongly associated with obesity-related dyslipidemia. The metabolic inter-relationships between weight loss induced changes in waist circumference, triglycerides, insulin sensitivity and small-dense LDL particles in clinically obese children and adolescents have not been studied.
  
  
  METHODS
  Seventy-five clinically obese boys and girls (standardized body mass index 3.07 ± 0.59, aged 8-18 years) were recruited. Anthropometric, body composition and cardiometabolic risk factors were measured pre- and post-weight loss.
  
  
  RESULTS
  There were highly significant reductions in anthropometric, body composition and cardiometabolic risk factors. Triglyceride change was positively correlated with LDL peak particle density and percentage LDL pattern B changes (relative abundance of small, dense LDL particles). Multiple regression analyses showed that changes in triglyceride concentration accounted for between 24 and 18% of the variance in LDL peak particle density and percentage LDL pattern B change, respectively. Changes in waist circumference and insulin sensitivity did not predict these changes in LDL characteristics.
  
  
  CONCLUSIONS
  Acute and highly significant weight loss significantly decreased LDL peak particle density and percentage LDL pattern B. The change in triglycerides was a strong predictor of LDL peak particle density and percentage LDL pattern B change.
authors.affiliation: Department of Academic Endocrinology, Diabetes and Metabolism, University of Hull, Hull, UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Hobkirk
authors.forename: R F
authors.initials: RF
authors.lastname: King
authors.forename: I
authors.initials: I
authors.lastname: Davies
authors.forename: N
authors.initials: N
authors.lastname: Harman
authors.forename: P
authors.initials: P
authors.lastname: Gately
authors.forename: P
authors.initials: P
authors.lastname: Pemberton
authors.forename: A
authors.initials: A
authors.lastname: Smith
authors.forename: J H
authors.initials: JH
authors.lastname: Barth
authors.forename: S
authors.initials: S
authors.lastname: Carroll
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D031204:Caloric Restriction; D002648:Child; D050171:Dyslipidemias / Q000453:epidemiology / Q000378:metabolism* / Q000517:prevention & control; D005260:Female; D006266:Health Education; D006801:Humans; D007333:Insulin Resistance; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D063766:Pediatric Obesity / Q000453:epidemiology / Q000378:metabolism* / Q000517:prevention & control; D010865:Pilot Projects; D014280:Triglycerides / Q000378:metabolism*; D055105:Waist Circumference; D015431:Weight Loss
chemical_list: D008077:Lipoproteins, LDL; D014280:Triglycerides
keywords: Insulin sensitivity; dense LDL; small; triglyceride; weight loss