title: Lack of association of IL-6 polymorphism with rheumatoid arthritis/type 1 diabetes: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to determine whether the interleukin (IL)-6 -174 single nucleotide polymorphism confers susceptibility to rheumatoid arthritis (RA) and type 1 diabetes (T1D) in multiple ethnic populations.
  
  
  METHODS
  A meta-analysis was conducted on the association between the IL-6 -174 polymorphism and RA/T1D susceptibility, using fixed and random effects models.
  
  
  RESULTS
  Thirteen studies were included in the meta-analysis: RA: seven studies, including six European and one Asian population; T1D: six studies, including five European and one South American population. There was no significant association both in allele and genotype comparisons between the IL-6 -174 polymorphism and RA/T1D in all study subjects. Moreover, meta-analysis stratified by ethnicity indicated no significant association between the gene and RA/T1D.
  
  
  CONCLUSIONS
  This meta-analysis suggests that the IL-6 -174 polymorphism might not confer susceptibility to RA/T1D.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81, Meishan Road, Hefei, 230032 Anhui, PR China.
authors.forename: Wang-Dong
authors.initials: WD
authors.lastname: Xu
authors.forename: Mo
authors.initials: M
authors.lastname: Zhou
authors.forename: Hui
authors.initials: H
authors.lastname: Peng
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D001172:Arthritis, Rheumatoid / Q000208:ethnology / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D015850:Interleukin-6
keywords: IL-6; Meta-analysis; Polymorphism; Rheumatoid arthritis; Type 1 diabetes