title: Testosterone-induced effects on lipids and inflammation.
abstract: Chronic pain has to be considered in all respects a debilitating disease and 10-20% of the world's adult population is affected by this disease. In the most general terms, pain is symptomatic of some form of dysfunction and (often) the resulting inflammatory processes in the body. In the study of pain, great attention has been paid to the possible involvement of gonadal hormones, especially in recent years. In particular, testosterone, the main androgen, is thought to play a beneficial, protective role in the body. Other important elements to be related to pain, inflammation, and hormones are lipids, heterogenic molecules whose altered metabolism is often accompanied by the release of interleukins, and lipid-derived proinflammatory mediators. Here we report data on interactions often not considered in chronic pain mechanisms.
authors.affiliation: Department of Medicine, Surgery and Neuroscience, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
authors.forename: Stella
authors.initials: S
authors.lastname: Vodo
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Bechi
authors.forename: Anna
authors.initials: A
authors.lastname: Petroni
authors.forename: Carolina
authors.initials: C
authors.lastname: Muscoli
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Aloisi
mesh_terms: D000728:Androgens / Q000378:metabolism; D000818:Animals; D059350:Chronic Pain / Q000276:immunology* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007378:Interleukins / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D013739:Testosterone / Q000378:metabolism*
chemical_list: D000728:Androgens; D007378:Interleukins; D013739:Testosterone