title: Nonfunctioning juxtaglomerular cell tumor.
abstract: The juxtaglomerular cell tumor (JGCT) is a rare renal tumor characterized by excessive renin secretion causing intractable hypertension and hypokalemia. However, asymptomatic nonfunctioning JGCT is extremely rare. Here, we report a case of nonfunctioning JGCT in a 31-year-old woman. The patient presented with a left renal tumor without hypertension or hypokalemia. Under a clinical diagnosis of renal cell carcinoma, radical nephrectomy was performed. The tumor was located in the middle portion adjacent to the renal pelvis, measuring 2 cm in size. Pathologically, the tumor was composed of cuboidal cells forming a solid arrangement, immunohistochemically positive for renin. Based on these findings, the tumor was diagnosed as JGCT. In cases with hyperreninism, preoperative diagnosis of JGCT is straightforward but difficult in nonfunctioning case. Generally, JGCT presents a benign biological behavior. Therefore, we should take nonfunctioning JGCT into the differential diagnoses for renal tumors, especially in younger patients to avoid excessive surgery.
authors.affiliation: Department of Urology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
authors.forename: Ryoko
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authors.lastname: Sakata
authors.forename: Hiroaki
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authors.lastname: Shimoyamada
authors.forename: Masahiro
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authors.lastname: Yanagisawa
authors.forename: Takayuki
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authors.lastname: Murakami
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authors.lastname: Makiyama
authors.forename: Noboru
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authors.lastname: Nakaigawa
authors.forename: Yoshiaki
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authors.lastname: Inayama
authors.forename: Kenichi
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authors.lastname: Ohashi
authors.forename: Yoji
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authors.lastname: Nagashima
authors.forename: Masahiro
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authors.lastname: Yao
authors.forename: Yoshinobu
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authors.lastname: Kubota