title: [Preparation of sustained release microspheres containing oxymatrine and their release characteristics in vitro].
abstract: OBJECTIVE
  To prepare poly(lactide-co-glycolide) (PLGA) microspheres containing Oxymatrine (OMT-PLGA-MS) and study their release characteristics in vitro.
  
  
  METHODS
  OMT-PLGA-MS was prepared with PLGA as carriers using double emulsion solvent evaporation method (W/O/W). The preparation technology of microspheres was optimized by orthogonal design, and the microspheres were characterized in terms of morphology, the rate of drug loading, encapsulation efficiency, and in vitro drug release.
  
  
  RESULTS
  The formed microspheres were spherical with smooth surfaces and the average size was (98.3 +/- 3.4) microm. The encapsulation efficiency and rate of drug loading were (70.14 +/- 3.47)% and (21.59 +/- 1.07)%, respectively. In vitro release study revealed that 84.63% of OMT was released from OMT-PLGA-MS in 240 hours, and the Higuchi model fitted OMT release pattern best.
  
  
  CONCLUSIONS
  OMT-PLGA-MS is prepared successfully and shows good sustained release characteristics.
authors.affiliation: School of Pharmacy, Guiyang Medical University, Guiyang 550004, China. 352380337@qq.com
authors.forename: Yang
authors.initials: Y
authors.lastname: Miao
authors.forename: Xiang-Chun
authors.initials: XC
authors.lastname: Shen
authors.forename: Chao-Da
authors.initials: CD
authors.lastname: Xiao
authors.forename: Liang-Fei
authors.initials: LF
authors.lastname: Wu
authors.forename: Xue
authors.initials: X
authors.lastname: Zhou
authors.forename: Ling
authors.initials: L
authors.lastname: Tao
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D004655:Emulsions / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011807:Quinolizines / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D012997:Solvents / Q000737:chemistry; D029909:Sophora / Q000737:chemistry; D000093842:Matrines
chemical_list: D000470:Alkaloids; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004655:Emulsions; D019344:Lactic Acid; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011807:Quinolizines; D012997:Solvents; C037573:oxymatrine; D000093842:Matrines