title: The effects of physical activity and exercise on brain-derived neurotrophic factor in healthy humans: A review.
abstract: The purpose of this study was to summarize the effects of physical activity and exercise on peripheral brain-derived neurotrophic factor (BDNF) in healthy humans. Experimental and observational studies were identified from PubMed, Web of Knowledge, Scopus, and SPORT Discus. A total of 32 articles met the inclusion criteria. Evidence from experimental studies suggested that peripheral BDNF concentrations were elevated by acute and chronic aerobic exercise. The majority of the studies suggested that strength training had no influence on peripheral BDNF. The results from most observational studies suggested an inverse relationship between the peripheral BDNF level and habitual physical activity or cardiorespiratory fitness. More research is needed to confirm the findings from the observational studies.
authors.affiliation: Centre of Research in Childhood Health, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Huang
authors.forename: K T
authors.initials: KT
authors.lastname: Larsen
authors.forename: M
authors.initials: M
authors.lastname: Ried-Larsen
authors.forename: N C
authors.initials: NC
authors.lastname: Møller
authors.forename: L B
authors.initials: LB
authors.lastname: Andersen
mesh_terms: D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003071:Cognition / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D009043:Motor Activity / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology*; D055070:Resistance Training
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: brain-derived neurotrophic factor; cardiorespiratory fitness; cognitive function; exercise; physical activity