title: Regulation of an enzyme cascade reaction by a DNA machine.
abstract: A strategy for the regulation of enzyme cascade reaction efficiency by a DNA machine in vitro is presented. Two cascade enzymes (GOx and HRP) are attached to the DNA machine, and the enzyme cascade reaction shows much higher efficiency when the two enzymes are brought closer by the DNA machine than when they are distant.
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Xin
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
authors.forename: Zhongqiang
authors.initials: Z
authors.lastname: Yang
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Liu
mesh_terms: D004247:DNA / Q000737:chemistry*; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism*; D005949:Glucose Oxidase / Q000737:chemistry / Q000378:metabolism*; D006735:Horseradish Peroxidase / Q000737:chemistry / Q000378:metabolism*
chemical_list: D004800:Enzymes, Immobilized; D004247:DNA; D005949:Glucose Oxidase; D006735:Horseradish Peroxidase
keywords: DNA regulation; DNA structures; cascade reactions; enzymes; molecular devices