title: Decreased serum 5-oxoproline in TB patients is associated with pathological damage of the lung.
abstract: BACKGROUND
  Tuberculosis (TB) is a serious world-wide health problem, causing millions of deaths every year. Metabolomics is a relatively new approach to identify disease specific biomarkers. However, there is little information available on metabolite biomarkers in TB. In this study, we used gas chromatography/time-of-flight mass spectrometry (GC/TOF-MS) to identify serum metabolite biomarkers associated with the active state of TB.
  
  
  METHODS
  Potential biomarkers were selected by comparing serum metabolites in 10 healthy donors with 10TB patients, and in 6TB patients before and after treatment. Selected biomarkers were then validated using a larger population of samples from 120 healthy donors and 120TB patients derived from different clinical backgrounds
  
  
  RESULTS
  The 5-oxoproline level was consistently low in patients with active TB. Further validation in larger population of clinical samples showed that 5-oxoproline was associated with pathological damage of the lung but not with age, sex, or bacterial burden in TB patients.
  
  
  CONCLUSIONS
  Serum 5-oxoproline may be a useful biomarker for active TB and pathological damage of the lung.
authors.affiliation: Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China.
authors.forename: Nanying
authors.initials: N
authors.lastname: Che
authors.forename: Jianhua
authors.initials: J
authors.lastname: Cheng
authors.forename: Haijing
authors.initials: H
authors.lastname: Li
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xuxia
authors.initials: X
authors.lastname: Zhang
authors.forename: Zhixin
authors.initials: Z
authors.lastname: Ding
authors.forename: Fangting
authors.initials: F
authors.lastname: Dong
authors.forename: Chuanyou
authors.initials: C
authors.lastname: Li
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008168:Lung / Q000473:pathology*; D008297:Male; D055432:Metabolomics; D011761:Pyrrolidonecarboxylic Acid / Q000097:blood*; D015203:Reproducibility of Results; D014376:Tuberculosis / Q000097:blood* / Q000473:pathology*
chemical_list: D015415:Biomarkers; D011761:Pyrrolidonecarboxylic Acid