title: Fusion of gamma scintigraphic and magnetic resonance images improves the anatomical delineation of radiotracer for the assessment of gastrointestinal transit.
abstract: OBJECTIVE
  This paper describes the use of gamma scintigraphic and magnetic resonance (MR) fusion images for improving the anatomical delineation of orally administered radiotracers used in gastrointestinal (GI) transit investigations.
  
  
  METHODS
  Ten healthy volunteers ingested enteric-coated gelatin capsules containing 4.4 ± 1.1 MBq SmCl3-labelled resin. Four external body markers containing Sm and Gd-DTPA were placed on the left and right lower costal margins and iliac crests of each volunteer. Anterior and posterior planar images were acquired hourly for 9 h, followed by a final single photon emission computed tomography (SPECT) image and subsequent T1-weighted images using a 1.5 T MR system. Coronal scintigraphic images were fused with MR images and assessed for diagnostic information.
  
  
  RESULTS
  The fused images revealed a combination of the tissue and organ anatomy with an overlay of the distribution of the tracer. Compared with conventional scintigraphic imaging alone, SPECT-MR fused images improved the localization of spatial and temporal movements of the radiotracer throughout the GI tract.
  
  
  CONCLUSIONS
  Fusion of SPECT and MR images in conjunction with sequential scintigraphic images improved the assessment of segmental GI transit. These have the potential to provide more accurate diagnostic results and are visually powerful images that would have more widespread acceptance by nonspecialists.
authors.affiliation: University of Malaya Research Imaging Centre, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Chai-Hong
authors.initials: CH
authors.lastname: Yeong
authors.forename: Basri J J
authors.initials: BJ
authors.lastname: Abdullah
authors.forename: Kwan-Hoong
authors.initials: KH
authors.lastname: Ng
authors.forename: Lip-Yong
authors.initials: LY
authors.lastname: Chung
authors.forename: Khean-Lee
authors.initials: KL
authors.lastname: Goh
authors.forename: Alan C
authors.initials: AC
authors.lastname: Perkins
mesh_terms: D000328:Adult; D005260:Female; D019786:Gadolinium DTPA; D005720:Gamma Rays; D005772:Gastrointestinal Transit; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D064847:Multimodal Imaging / Q000379:methods*; D011849:Radioactive Tracers; D011868:Radioisotopes; D012493:Samarium; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D011849:Radioactive Tracers; D011868:Radioisotopes; D012493:Samarium; D019786:Gadolinium DTPA