title: Molecular and cytogenetic characterization of two patients with recurrent miscarriages and X-autosome translocation.
abstract: OBJECTIVE
  To report two patients with recurrent miscarriages and unique reciprocal X-autosomal translocation.
  
  
  METHODS
  Cytogenetic analysis was performed using G-banding and Molecular cytogenetic analysis by Fluorescence in situ hybridization to confirm the breakpoint regions.
  
  
  RESULTS
  The chromosomal analysis of the two cases revealed a karyotype of 46,X,t(X;22)(p11.21;q13.3) in the first patient and 46,X,t(X;2)(q22;q13) in second patient. Both the cases were confirmed by using whole chromosome paint probes.
  
  
  CONCLUSIONS
  This is the rare report of X-autosomal translocations with unique breakpoint regions and their association with recurrent miscarriages. The translocation breakpoint in case 2 on Xq22 and on Xp11.21 in case 1 might be a risk factor for recurrent miscarriages. Here the impact of the X-autosomal translocations is discussed.
authors.affiliation: Diagnostics Division Center for DNA Fingerprinting and Diagnostics, Tuljaguda Complex, 4-1-714, Hyderabad, Andhra Pradesh, India.
authors.forename: Usha R
authors.initials: UR
authors.lastname: Dutta
authors.forename: Vijaya Kumar
authors.initials: VK
authors.lastname: Pidugu
authors.forename: Ashwin B
authors.initials: AB
authors.lastname: Dalal
keywords: Recurrent miscarriages; X-autosomal translocations; translocations