title: Photoswitchable protein degradation: a generalizable control module for cellular function?
abstract: In this issue of Chemistry & Biology, Renicke et al. report a photosensitive degron (psd) consisting of the LOV2 domain fused to a protein degradation sequence. This design enabled light-dependent protein degradation in yeast. When psd was fused to cell-cycle-dependent proteins, it controlled cell cycle by light with spatiotemporal precision.
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario, M5S 3G9, Canada. e.mills@mail.utoronto.ca
authors.forename: Evan
authors.initials: E
authors.lastname: Mills
authors.forename: Kevin
authors.initials: K
authors.lastname: Truong