title: Size matters, so does shape: Inhibition of transcription of T7 RNA polymerase by iron(II) clathrochelates.
abstract: Coordination and organoelement compounds are rarely proposed as the drug candidates despite their vast potential in the area owing to their strictly controlled geometry and rather extensive surface. This is the first example of the inhibition of transcription in the system of T7 RNA polymerase by cage metal complexes. Their IC50 values reach as low as the nanomolar range, placing them among the most potent metal-based transcription inhibitors.
authors.affiliation: Nesmeyanov Institute of Organoelement Compounds RAS, Moscow, Russia.
authors.forename: Valentin V
authors.initials: VV
authors.lastname: Novikov
authors.forename: Oleg A
authors.initials: OA
authors.lastname: Varzatskii
authors.forename: Valentina V
authors.initials: VV
authors.lastname: Negrutska
authors.forename: Yurii N
authors.initials: YN
authors.lastname: Bubnov
authors.forename: Larisa G
authors.initials: LG
authors.lastname: Palchykovska
authors.forename: Igor Y
authors.initials: IY
authors.lastname: Dubey
authors.forename: Yan Z
authors.initials: YZ
authors.lastname: Voloshin
mesh_terms: D017123:Bacteriophage T7 / Q000201:enzymology*; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000378:metabolism*; D058085:Iron Compounds / Q000737:chemistry / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects*; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D058085:Iron Compounds; D014764:Viral Proteins; C062210:bacteriophage T7 RNA polymerase; D012321:DNA-Directed RNA Polymerases