title: Risk-based screening for thyroid dysfunction during pregnancy.
abstract: OBJECTIVE
  We conducted the study to see the incidence of thyroid dysfunction in women with obstetrical high-risk factors.
  
  
  METHODS
  We retrospectively reviewed medical charts of high-risk pregnant women who had examination for thyroid function during pregnancy. Women were divided according to clinical presentation, symptoms of thyroid disease and those with a personal history of thyroid disease (thyroid disease, n = 32), intrauterine growth restriction (IUGR, n = 115), diabetes mellitus (diabetes, n = 115), hypertension (n = 63), intrauterine fetal death (IUFD, n = 52), and placental abruption (abruption, n = 15). The incidence of thyroid dysfunctions including hyperthyroidism or hypothyroidism was compared.
  
  
  RESULTS
  The overall prevalence of thyroid dysfunction was 24.7%. The incidence of thyroid dysfunction in each group was as follows: 31% in thyroid disease, 25% in IUGR, 30% in diabetes, 27% in hypertension, 12% in IUFD, and 7% in abruption. Except IUFD, the incidence was not statistically significant from the group of thyroid disease (thyroid disease versus IUFD, P = 0.03 by χ (2) test). Thyroid disease represented for only 10% of all thyroid dysfunctions.
  
  
  CONCLUSIONS
  Testing of women with a personal history or current symptoms of thyroid disease during pregnancy may be insufficient to detect women with thyroid dysfunction, who will become at high-risk pregnancy.
authors.affiliation: Department of Obstetrics & Gynecology, Miyazaki Medical Association Hospital, 738-1 Shinbepputyo-Funato, Miyazaki, Japan.
authors.forename: Masanao
authors.initials: M
authors.lastname: Ohashi
authors.forename: Seishi
authors.initials: S
authors.lastname: Furukawa
authors.forename: Kaori
authors.initials: K
authors.lastname: Michikata
authors.forename: Katsuhide
authors.initials: K
authors.lastname: Kai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sameshima
authors.forename: Tsuyomu
authors.initials: T
authors.lastname: Ikenoue
mesh_terms: D000328:Adult; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology*; D007037:Hypothyroidism / Q000453:epidemiology*; D007564:Japan / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D018566:Pregnancy, High-Risk; D011296:Prenatal Diagnosis / Q000379:methods*; D013959:Thyroid Diseases / Q000453:epidemiology*; D013960:Thyroid Function Tests / Q000379:methods