title: [Tolerance of antiretroviral drugs during pregnancy].
abstract: Prevention of transmission from mother to child HIV-1 with antire-trovirals is extraordinarily effective. The risk is now almost zero for a woman properly followed, early in her pregnancy. Rapid expansion of this prophylaxis gives hope of a virtual elimination of pediatric AIDS at a global scale. In 2012, more than 500,000 women around the world have received antiretrovirals during pregnancy making the issue of tolerance crucial. Even if the health of children "exposed-uninfected" is not a concern in the vast majority of cases, a series of biological, clinical and imaging alerts justifies attention. Genotoxic profile of zidovudine, and more generally that of antiretroviral nucleoside analogues for mitochondrial and/or nuclear DNA is certainly the main questions regarding the potential long-term effects to the child.
authors.affiliation: Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Cité Sorbonne, Institut Imagine, Paris, France. stephane-blanche@nck.aphp.fr
authors.forename: Stéphane
authors.initials: S
authors.lastname: Blanche
authors.forename: Josiane
authors.initials: J
authors.lastname: Warszawski
mesh_terms: D000014:Abnormalities, Drug-Induced; D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control; D044966:Anti-Retroviral Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D004272:DNA, Mitochondrial / Q000187:drug effects; D005260:Female; D015658:HIV Infections / Q000635:transmission*; D015497:HIV-1; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D009153:Mutagens; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D047928:Premature Birth / Q000139:chemically induced; D015215:Zidovudine / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D044966:Anti-Retroviral Agents; D004272:DNA, Mitochondrial; D009153:Mutagens; D015215:Zidovudine