title: Targeting T cells responsive to the priming epitope prevent the relapsing phase of experimental autoimmune encephalomyelitis.
abstract: Upon recovery from the initial episode of experimental autoimmune encephalomyelitis (EAE), virtually all SJL mice develop relapsing/remitting episodes of disease. These relapses may occur due to the reactivation of memory T cells initially stimulated as part of the disease-inducing protocol or naïve T-cell populations stimulated by distinct encephalitogens derived from the inflammatory disease process (epitope spread). We have used encephalitogen-specific non-linear peptide octamers to modify the course of relapsing EAE (rEAE) in SJL mice immunized with an oliogodendrocyte-specific protein peptide (OSP 55-71). Our studies show that the peptide-octamers, which target the T cells stimulated by the priming encephalitogen, but not other candidate encephalitogens, prevent rEAE.
authors.affiliation: Immunology Research Group, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Keith W
authors.initials: KW
authors.lastname: Wegmann
authors.forename: H G Archie
authors.initials: HG
authors.lastname: Bouwer
authors.forename: Cynthia R
authors.initials: CR
authors.lastname: Gregory
authors.forename: Ruth H
authors.initials: RH
authors.lastname: Whitham
authors.forename: David J
authors.initials: DJ
authors.lastname: Hinrichs
mesh_terms: D000208:Acute Disease; D000818:Animals; D002465:Cell Movement / Q000276:immunology; D057167:Claudins / Q000276:immunology* / Q000494:pharmacology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D005260:Female; D007114:Immunization; D007156:Immunologic Memory / Q000276:immunology; D007167:Immunotherapy / Q000379:methods*; D051379:Mice; D008815:Mice, Inbred Strains; D010446:Peptide Fragments / Q000276:immunology / Q000494:pharmacology*; D055502:Secondary Prevention; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
chemical_list: C120453:CLDN11 protein, human; D057167:Claudins; D018984:Epitopes, T-Lymphocyte; D010446:Peptide Fragments