title: Revised estimates of mortality from the Birmingham Burn Centre, 2001-2010: a continuing analysis over 65 years.
abstract: OBJECTIVE
  The Birmingham Burn Centre has continued to publish mortality data over the last 65 years. It is one of the longest running cross-sectional cohort studies in the world. We present the latest data from the study, with a comparison to previous results.
  
  
  BACKGROUND
  Results from the previous decade failed to show any improvement in mortality despite perceived advances in burn care. The aim of this update was to establish current mortality statistics and ascertain whether improvement had now been made.
  
  
  METHODS
  Data were collected for a 10-year period on all burn-injured patients admitted to the Birmingham Burn Centre (Birmingham Children's Hospital, Selly Oak Hospital, and Queen Elizabeth Hospital Birmingham). Patients' age, percentage of burn, date of injury, and outcome were recorded and analyzed with both probit and logistic regression analyses.
  
  
  RESULTS
  A total of 4577 patients were included in the analysis, with a mean total body surface area (TBSA) burn of 7.2% and a mean age of 22 years. Comparison of probit model results with previous results demonstrates improvement in predicted mortality and lethal area (LA50) of burns. Logistic regression produces similar results to the probit analysis. Trend analysis proved a statistically significant improvement in mortality.
  
  
  CONCLUSIONS
  The last decade of burn care at Birmingham Burn Centre demonstrates an improvement in predicted mortality and LA50. This reflects our structured, multidisciplinary approach to burn-injured patients, early surgical excision and wound closure, and general advances in the intensive care of patients.
authors.affiliation: *West Midlands Regional Burns Centre, University Hospitals of Birmingham NHS Foundation Trust, New Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham, United Kingdom †Birmingham Children's Hospital NHS Foundation Trust, Steelhouse Lane, Birmingham, United Kingdom ‡Wellcome Trust Clinical Research Facility, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom.
authors.forename: Philippa C
authors.initials: PC
authors.lastname: Jackson
authors.forename: Joseph
authors.initials: J
authors.lastname: Hardwicke
authors.forename: Amy
authors.initials: A
authors.lastname: Bamford
authors.forename: Peter
authors.initials: P
authors.lastname: Nightingale
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Wilson
authors.forename: Remo
authors.initials: R
authors.lastname: Papini
authors.forename: Naiem
authors.initials: N
authors.lastname: Moiemen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002053:Burn Units / Q000706:statistics & numerical data*; D002056:Burns / Q000175:diagnosis / Q000401:mortality*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D017052:Hospital Mortality / Q000639:trends; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate / Q000639:trends; D015599:Trauma Severity Indices; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult