title: Anti-arthritic and immunosuppressive activities of substituted triterpenoidal candidates.
abstract: We herein report the anti-arthritic and immunosuppressive activities of some synthesized substituted terpenoidal structure. Forty-four triterpenoid derivatives 1-21 containing a carboxylic, ester, amide and ketone groups attached to a triterpene moiety were conveniently synthesized and screened for their anti-arthritic and immunosuppressive activities. Synthetic triterpenoidal structures linked to a different function groups seem to be a promising approach in the search for novel leads for potent anti-arthritic and immunosuppressive agents. The detailed synthetic pathways of obtained compounds and anti-arthritic and immunosuppressive activities were reported.
authors.affiliation: Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
authors.forename: Amer M
authors.initials: AM
authors.lastname: Alanazi
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Al-Omar
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Abdulla
authors.forename: Abd El-Galil E
authors.initials: Ael-G
authors.lastname: Amr
mesh_terms: D000818:Animals; D002417:Cattle; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002917:Chymopapain; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D020370:Osteoarthritis, Knee / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology; D014315:Triterpenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D014315:Triterpenes; D002917:Chymopapain