title: Prevalence of extra-esophageal cancers in patients with Barrett's esophagus and esophageal adenocarcinoma.
abstract: OBJECTIVE
  To compare the prevalence of extra-esophageal cancers in patients diagnosed with Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) with SEER database.
  
  
  METHODS
  Patients with BE and EAC are part of a NIH supported Familial Barrett's investigation involving personal and family history and pathology correlation recorded in the database. Data pertaining to extra-esophageal cancers in the proband was extracted into an excel datasheet for analysis. Expected prevalence obtained from SEER (Surveillance, Epidemiology and End Results) NIH database (1973-2006) for the general population, matched for age, was compared with our cohort. Chi-square test was used for statistical analysis.
  
  
  RESULTS
  There were 1091 probands in the database of whom 876 had complete personal history. The mean age was 57.6 (5-84 years) with 807 Caucasians and 710 males. Overall incidence of extra-esophageal cancers was higher in our cohort when compared with the general population.
  
  
  CONCLUSIONS
  There is a strong association of certain cancer types in patients with BE and EAC. However, further epidemiologic and genetic research is needed for investigation and development of genetic fingerprints.
authors.affiliation: Department of Surgery, Creighton University, School of Medicine, Omaha, NE 68131, USA.
authors.forename: Anjan
authors.initials: A
authors.lastname: Talukdar
authors.forename: Amitabh
authors.initials: A
authors.lastname: Chak
authors.forename: Tommy
authors.initials: T
authors.lastname: Lee
authors.forename: Xiang
authors.initials: X
authors.lastname: Fang
authors.forename: Patrice
authors.initials: P
authors.lastname: Watson
authors.forename: Henry
authors.initials: H
authors.lastname: Lynch
authors.forename: Sumeet
authors.initials: S
authors.lastname: Mittal
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000453:epidemiology* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology; D055815:Young Adult