title: Diffusion-weighted magnetic resonance imaging evaluation of intra-abdominal sites of implants to predict likelihood of suboptimal cytoreductive surgery in patients with ovarian carcinoma.
abstract: OBJECTIVE
  To analyse the diagnostic accuracy and to establish a predictive score based on diffusion-weighted magnetic resonance imaging (DWMRI) compared to exploratory laparotomy (EL) for predicting suboptimal cytoreductive surgery for different intra-abdominal sites of implants in patients with ovarian cancer.
  
  
  METHODS
  Thirty-four patients with advanced ovarian carcinoma were studied. Preoperative DWMRI of the abdomen and pelvis was performed. DWMRI findings were compared with EL. Ten anatomical sites were selected for inclusion in the score. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy for suboptimal cytoreduction were calculated for both DWMRI and EL. Receiver operating characteristic (ROC) curve analysis was used to assess the ability to predict suboptimal cytoreduction.
  
  
  RESULTS
  Using predictive score, ROC curves were generated with an area under the curve of 0.938 for DWMRI and 0.947 for EL (P < 0.0001). For DWMRI, a score ≥6 had the highest overall accuracy at 91.1 % and identified patients with unnecessary EL with a sensitivity of 75 %. For EL, a score ≥4 had the highest overall accuracy at 88.2 % and was able to identify patients with unnecessary EL with a sensitivity of 87.5 %.
  
  
  CONCLUSIONS
  DWMRI is an emerging technique that may be useful to predict suboptimal cytoreduction in ovarian cancer.
  
  
  CONCLUSIONS
  • DWMRI is increasingly used in ovarian cancer. • DWMRI is an accurate technique for depicting intra-abdominal sites of implants • DWMRI is useful for predicting optimal cytoreductive surgical outcome. • We report a high predictive value similar to exploratory laparotomy.
authors.affiliation: Obstetrics and Gynecology Department, Hospital Universitario Quiron Madrid, Calle Diego de Velazquez, 1. 28223. Pozuelo de Alarcon, Madrid, Spain. mespada.mad@quiron.es
authors.forename: Mercedes
authors.initials: M
authors.lastname: Espada
authors.forename: Jose R
authors.initials: JR
authors.lastname: Garcia-Flores
authors.forename: Mar
authors.initials: M
authors.lastname: Jimenez
authors.forename: Elena
authors.initials: E
authors.lastname: Alvarez-Moreno
authors.forename: Mar
authors.initials: M
authors.lastname: De Haro
authors.forename: Lucia
authors.initials: L
authors.lastname: Gonzalez-Cortijo
authors.forename: Gines
authors.initials: G
authors.lastname: Hernandez-Cortes
authors.forename: Vicente
authors.initials: V
authors.lastname: Martinez-Vega
authors.forename: Ricardo
authors.initials: R
authors.lastname: Sainz De La Cuesta
mesh_terms: D000005:Abdomen / Q000473:pathology; D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D002277:Carcinoma / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007813:Laparotomy; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D011237:Predictive Value of Tests; D012372:ROC Curve; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome