title: Annotation of genes having candidate somatic mutations in acute myeloid leukemia with whole-exome sequencing using concept lattice analysis.
abstract: In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes having candidate somatic mutations in whole-exome sequencing in acute myeloid leukemia (AML). We selected 45 highly mutated genes with whole-exome sequencing in 10 normal matched samples of the AML-M2 subtype. To evaluate these genes, we performed concept lattice analysis and annotated these genes with existing knowledge databases.
authors.affiliation: Division of Biomedical Informatics, Seoul National University Biomedical Informatics (SNUBI) and Systems Biomedical Informatics National Core Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea.
authors.forename: Kye Hwa
authors.initials: KH
authors.lastname: Lee
authors.forename: Jae Hyeun
authors.initials: JH
authors.lastname: Lim
authors.forename: Ju Han
authors.initials: JH
authors.lastname: Kim
keywords: DNA mutational analysis; DNA sequence analysis; acute myeloid leukemia; biolattice; concept lattice analysis; oncogenes