title: Salivary flow rates among women diagnosed with benign and malignant tumors.
abstract: The purpose of this study was to compare salivary flow rates (SWS) among patients diagnosed with benign and varying malignant solid tumors with the comparison group, prior to the initiation of any treatment. An evaluation of the results found that mean baseline SWS flow rates were higher for healthy patients (1.55 ml/min) when compared to patients diagnosed with benign tumors (1.13 ml/min), breast cancer (1.09 ml/min), and reproductive carcinomas (0.94 ml/min). The overall model (F = 7.76; p < .001) and the Dunnett's post hoc analyses were statistically significant at the p < .001 level. Additionally, medications, race, and season of the year had significant effects on mean SWS flow rates. The results suggest that salivary secretion is lower among both benign and malignant tumor subjects prior to the initiation of treatment. Salivary evaluations of subjects prior to treatment may be useful in identifying individuals at risk for oral complications during chemotherapy.
authors.affiliation: Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, USA.
authors.forename: Joel J
authors.initials: JJ
authors.lastname: Napeñas
authors.forename: Leslie
authors.initials: L
authors.lastname: Miles
authors.forename: Cynthia
authors.initials: C
authors.lastname: Guajardo-Streckfus
authors.forename: Charles F
authors.initials: CF
authors.lastname: Streckfus
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000970:Antineoplastic Agents / Q000009:adverse effects; D001943:Breast Neoplasms / Q000150:complications* / Q000473:pathology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D005833:Genital Neoplasms, Female / Q000150:complications* / Q000473:pathology; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D012463:Saliva / Q000378:metabolism; D012636:Secretory Rate; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D014987:Xerostomia / Q000209:etiology*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents