title: Liver or blood-stage arrest during malaria sporozoite immunization: the later the better?
abstract: So far, the best immunization strategies to achieve high levels of protection against malaria are based on whole parasites. Complete sterile protection can be obtained in rodent models after immunization with sporozoites and chemoprophylaxis, or with sporozoites attenuated either genetically or by radiation. These approaches target specific stages, with arrests occurring at different time-points of the parasite life cycle. Here, we review these different approaches in relation to their capacity to induce protection in both Plasmodium berghei and Plasmodium yoelii models. The combined data suggest that maximal liver-stage exposure without further development into blood stages may induce the most efficient protection in mice.
authors.affiliation: Radboud University Nijmegen Medical Centre, Department of Medical Microbiology, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Krystelle
authors.initials: K
authors.lastname: Nganou-Makamdop
authors.forename: Robert W
authors.initials: RW
authors.lastname: Sauerwein
mesh_terms: D000818:Animals; D006801:Humans; D007114:Immunization; D008288:Malaria / Q000469:parasitology* / Q000517:prevention & control*; D017780:Malaria Vaccines / Q000276:immunology*; D051379:Mice; D010962:Plasmodium berghei / Q000276:immunology*; D010967:Plasmodium yoelii / Q000276:immunology*
chemical_list: D017780:Malaria Vaccines