title: Prognostic factors and outcome of undifferentiated endometrial sarcoma treated by multimodal therapy.
abstract: OBJECTIVE
  To describe the natural history, prognostic factors, and optimal treatment modalities of undifferentiated endometrial sarcoma (UES).
  
  
  METHODS
  A retrospective review was conducted of 30 patients with UES treated at Institut Gustave-Roussy, France, between January 1978 and December 2008. Clinical and pathologic variables, treatment modalities, and outcomes were assessed.
  
  
  RESULTS
  Disease was advanced in most cases: FIGO stage III-IV in 70% of patients. Overall, 29 patients (96.7%) underwent hysterectomy as part of the initial surgical treatment; however, only 18 (60.0%) attained complete macroscopic resection. The incidence of pelvic and/or para-aortic lymph-node involvement at primary surgery or first recurrence was 44.4%. Median postoperative follow-up was 5 years; progression-free survival (PFS) and overall survival (OS) were 9.7 and 23 months, respectively. No differences in OS and PFS were observed by staging subgroup (FIGO vs the American Joint Committee on Cancer). Only postoperative pelvic radiotherapy with or without brachytherapy correlated with improved PFS (19.1 vs 6.5 months; P=0.04) and OS (54.5 vs 16.7 months; P=0.01) in a univariate analysis.
  
  
  CONCLUSIONS
  Neither staging system was optimal for risk stratification. Multimodal therapy was recommended after surgery.
authors.affiliation: Department of Medicine, Institut Gustave-Roussy, Villejuif, France. gabriel.malouf@gmail.com
authors.forename: Gabriel G
authors.initials: GG
authors.lastname: Malouf
authors.forename: Catherine
authors.initials: C
authors.lastname: Lhommé
authors.forename: Pierre
authors.initials: P
authors.lastname: Duvillard
authors.forename: Philippe
authors.initials: P
authors.lastname: Morice
authors.forename: Christine
authors.initials: C
authors.lastname: Haie-Meder
authors.forename: Patricia
authors.initials: P
authors.lastname: Pautier
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D018203:Sarcoma, Endometrial Stromal / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome