title: Chemical and biological characterization of polysaccharides isolated from Ilex paraguariensis A. St.-Hil.
abstract: The potential gastroprotection of polysaccharides (SP) isolated from maté (Ilex paraguariensis) leaves of different growth stages, under different sunlight conditions and of processing methods were evaluated. The SP consist of type I arabinogalactan (AG1) containing a (1→4)-linked β-Galp chain, with substituents of arabinosyl units at O-6. This arabinogalactan seems to be attached to rhamnosyl units from a RG1, via 1→4 linkage. Oral administration of SP1, SP9, SP10, SP11 and SP12 inhibited the gastric lesions induced by ethanol in rats. Altogether, the present data indicate the therapeutic role of maté polysaccharides against gastric lesion and propose its use or of its crude plant extract as a phytotherapic medicine.
authors.affiliation: Department of Pharmacology, Sector of Biological Sciences, Federal University of Parana, Curitiba, PR, Brazil.
authors.forename: Daniele
authors.initials: D
authors.lastname: Maria-Ferreira
authors.forename: Nessana
authors.initials: N
authors.lastname: Dartora
authors.forename: Luisa Mota
authors.initials: LM
authors.lastname: da Silva
authors.forename: Isabela Tiemy
authors.initials: IT
authors.lastname: Pereira
authors.forename: Lauro Mera
authors.initials: LM
authors.lastname: de Souza
authors.forename: Daniel Suss
authors.initials: DS
authors.lastname: Ritter
authors.forename: Marcello
authors.initials: M
authors.lastname: Iacomini
authors.forename: Maria Fernanda de Paula
authors.initials: MF
authors.lastname: Werner
authors.forename: Guilherme Lanzi
authors.initials: GL
authors.lastname: Sassaki
authors.forename: Cristiane Hatsuko
authors.initials: CH
authors.lastname: Baggio
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000431:Ethanol; D005260:Female; D030019:Ilex paraguariensis / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D011134:Polysaccharides / Q000008:administration & dosage* / Q000737:chemistry* / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D010936:Plant Extracts; D011134:Polysaccharides; D000431:Ethanol