title: [Studies on metabolism of total terpene ketones from Swertia mussotii with human intestinal bacteria].
abstract: OBJECTIVE
  To study the metabolism of total terpene ketones from Swertia mussotii with human intestinal bacteria.
  
  
  METHODS
  Total terpene ketones were incubated with human intestinal bacteria under an anaerobic environment and at 37 degrees C. The metabolites were extracted by ethyl acetate processing, detected by HPLC-DAD method. A qualitative analysis was made for its metabolites by HPLC-MS.
  
  
  RESULTS
  Eight metabolites were detected from total terpene ketones from S. mussotii with human intestinal bacteria, and two of them were preliminarily identified as gentianine and mangiferin aglycon.
  
  
  CONCLUSIONS
  Total terpene ketones can be metabolized with human intestinal bacteria, which provides basis for experiments on the metabolism process total terpene ketones from S. mussotii with human intestinal bacteria.
authors.affiliation: Tianjin University of Traditional Chinese Medicine, Tianjin 300073, China. 493152889@qq.com
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
authors.forename: Cheng-Wang
authors.initials: CW
authors.lastname: Tian
authors.forename: Shuai
authors.initials: S
authors.lastname: Wu
authors.forename: Xiu-Wei
authors.initials: XW
authors.lastname: Yang
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Wang
authors.forename: Tie-Jun
authors.initials: TJ
authors.lastname: Zhang
mesh_terms: D000470:Alkaloids / Q000378:metabolism; D000693:Anaerobiosis; D001419:Bacteria / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D007659:Ketones / Q000378:metabolism*; D013058:Mass Spectrometry; D029967:Swertia / Q000378:metabolism*; D013729:Terpenes / Q000378:metabolism*; D044004:Xanthones / Q000378:metabolism
chemical_list: D000470:Alkaloids; D007659:Ketones; D013729:Terpenes; D044004:Xanthones; C013592:mangiferin; C060402:gentianine