title: Synthesis and cytotoxic activity of some derivatives of alkyl piperidine.
abstract: Synthesis of novel phenacyl derivatives of alkyl piperidine as cytotoxic agents via simple and single step reaction procedure is going to be reported here. Twelve new compounds were successfully synthesized in moderate yield and in solid form. Their synthesis was confirmed by TLC, melting point, CHN analysis and through different spectral studies such as UV, IR, Mass and proton NMR. The advantages of this synthetic route are simple operation, mild reaction conditions and good yields. These newly synthesized derivatives were extensively explored for their cytotoxicity by brine shrimp lethality assay.
authors.affiliation: Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi, Pakistan. sarwatsony@yahoo.com
authors.forename: Sarwat
authors.initials: S
authors.lastname: Jahan
authors.forename: Shamim
authors.initials: S
authors.lastname: Akhtar
authors.forename: Zafar Saied
authors.initials: ZS
authors.lastname: Saify
authors.forename: Nousheen
authors.initials: N
authors.lastname: Mushtaq
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Sial
authors.forename: Arfa
authors.initials: A
authors.lastname: Kamil
authors.forename: Muhammed
authors.initials: M
authors.lastname: Arif
mesh_terms: D000478:Alkylation; D000818:Animals; D001156:Artemia / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D010880:Piperidines / Q000737:chemistry* / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: D010880:Piperidines