title: Giant myofibroblastoma of the male breast: a case report and literature review.
abstract: Myofibroblastomas are soft-tissue neoplasms that are thought to arise from myofibroblasts. They are mostly observed in males 41-85 years of age; however, this lesion also occurs in women. The usual clinical presentation is a unilateral painless lump that is not adherent to overlying or underlying structures. Microscopically, myofibroblastomas can be divided into 5 subtypes: classical, epithelioid, collagenised, cellular, and infiltrative. Mammary ducts and lobules are absent in the typical histological subtypes and the adjacent breast parenchyma may form a pseudocapsule. The majority of myofibroblastomas are immunoreactive for CD34, desmin, smooth muscle actin, and vimentin and are negative for cytokeratin and S-100 protein. We present a case of a giant myofibroblastoma arising in the background of gynecomastia in an adult male.
authors.affiliation: Department of Surgical Disciplines, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, Delhi 110029, India.
authors.forename: Kamal
authors.initials: K
authors.lastname: Kataria
authors.forename: Anurag
authors.initials: A
authors.lastname: Srivastava
authors.forename: Lavleen
authors.initials: L
authors.lastname: Singh
authors.forename: Vaishali
authors.initials: V
authors.lastname: Suri
authors.forename: Rajni
authors.initials: R
authors.lastname: Yadav
keywords: breast; gynecomastia; mesenchymal; myofibroblastoma; spindle cell