title: Treatment planning in molecular radiotherapy.
abstract: In molecular radiotherapy a radionuclide or a radioactively labelled pharmaceutical is administered to the patient. Treatment planning therefore comprises the determination of activity to administer. This administered activity should maximize tumour cell sterilization while minimizing normal tissue damage. In this work we present different approaches that are frequently used for determining the suitable activity. These approaches may be cohort- based as in chemotherapy, or patient-specific using dosimetry based on individual biokinetics. The approaches are different with respect to the input complexity, the corresponding costs and - in consequence - the quality of the therapy. In addition, a general scheme for data collection and analysis is proposed. To develop an effective and safe treatment, elaborate data need to be obtained. The main challenges, however, are collecting these complex data and analyse them properly.
authors.affiliation: Medical Radiation Physics/Radiation Protection, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address: gerhard.glatting@medma.uni-heidelberg.de.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Glatting
authors.forename: Manuel
authors.initials: M
authors.lastname: Bardiès
authors.forename: Michael
authors.initials: M
authors.lastname: Lassmann
mesh_terms: D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000532:radiotherapy*; D011874:Radiometry / Q000379:methods*; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals
keywords: Dosimetrie; Molekulare Radiotherapie; Nuklearmedizin; Radionuklidtherapie; Therapieplannung; Therapy planning; dosimetry; molecular radiotherapy; nuclear medicine; targeted radionuclide therapy