title: The Pamela study: main findings and perspectives.
abstract: PAMELA (Pressioni Arteriose Monitorate E Loro Associazioni) is an epidemiological study, originally designed to determine the normality of home and ambulatory blood pressure values. The study was performed on 3,200 subjects, aged 25 to 74 years, randomly selected from the general population of Monza (Milan, Italy). In the study context we performed clinical, home and ambulatory blood pressure measurements, echocardiographic assessment of cardiac structure and function as well as laboratory examinations (glucose and lipids). Personal and family histories were collected. The same procedures were repeated 10 years later. During a 12-year follow-up, the incident cardiovascular events were validated. Cardiovascular and all-cause fatal events were collected for a 16-year follow-up. This article will review the main results of the PAMELA study, with particular emphasis on (1) the prognostic value of the different blood pressure measurements, (2) the relationships between metabolic variables and blood pressure and (3) the clinical relevance and prognostic importance of left ventricular mass values and alterations.
authors.affiliation: Clinica Medica, Department of Health Sciences, University of Milano-Bicocca, S. Gerardo Hospital, via Pergolesi, 20052, Monza, Milan, Italy. michele.bombelli@unimib.it
authors.forename: Michele
authors.initials: M
authors.lastname: Bombelli
authors.forename: Elena
authors.initials: E
authors.lastname: Toso
authors.forename: Maria
authors.initials: M
authors.lastname: Peronio
authors.forename: Danilo
authors.initials: D
authors.lastname: Fodri
authors.forename: Marco
authors.initials: M
authors.lastname: Volpe
authors.forename: Gianmaria
authors.initials: G
authors.lastname: Brambilla
authors.forename: Rita
authors.initials: R
authors.lastname: Facchetti
authors.forename: Roberto
authors.initials: R
authors.lastname: Sega
authors.forename: Guido
authors.initials: G
authors.lastname: Grassi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mancia
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D001795:Blood Pressure Determination / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D007558:Italy / Q000453:epidemiology; D011379:Prognosis
chemical_list: D001786:Blood Glucose