title: Improved selectivity of ZnNa3DTPA vs. Na5DTPA to abstract Cd2+ from plasma proteins in vitro.
abstract: Since no chelating agent has been clinically approved for the treatment of Cd(2+) intoxicated humans, we have previously investigated diethylenetriaminepentaacetic acid (Na5DTPA) to abstract this toxic metal from plasma proteins in vitro. In addition to the complete mobilization of Cd(2+), an inadvertent abstraction of Zn(2+) from metalloproteins was also observed. Therefore, we have evaluated the effect of ZnNa3DTPA on the plasma distribution of Ca, Cd, Cu, Fe and Zn after its addition to Cd(2+)-spiked rabbit plasma. ZnNa3DTPA was as efficient as Na5DTPA in abstracting Cd(2+) (100% removal), but it did not abstract Zn(2+). Thus, complexes between essential metals (e.g. Zn(2+)) and known chelating agents emerge as feasible candidates to decrease potential adverse side effects in patients.
authors.affiliation: Department of Chemistry, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada.
authors.forename: Elham Zeini
authors.initials: EZ
authors.lastname: Jahromi
authors.forename: Jürgen
authors.initials: J
authors.lastname: Gailer
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000737:chemistry*; D002104:Cadmium / Q000737:chemistry* / Q000302:isolation & purification*; D002614:Chelating Agents / Q000737:chemistry*; D004369:Pentetic Acid / Q000737:chemistry*; D011817:Rabbits
chemical_list: D001798:Blood Proteins; D002614:Chelating Agents; D002104:Cadmium; D004369:Pentetic Acid