title: Is methoxydine a new rapid acting antidepressant for the treatment of depression in alcoholics?
abstract: Methoxydine is a dissociative anaesthetic belonging to the arylcyclohexylamine class. This substance shows pharmacodynamic similarities with ketamine, a medication with demonstrated rapid-acting antidepressant effects. Like ketamine, results of binding assays have shown that methoxydine is an uncompetitive antagonist of NMDA receptor approximately as potent as ketamine, but less potent than PCP. Furthermore, unlike ketamine, it acts as a dopamine, serotonin, and noradrenaline reuptake inhibitor as well as an agonist at sigma-1, sigma-2, and opioid receptors. The hypothesis is that methoxydine can produce rapid antidepressant effects in depressed patients with high risk of suicide, including depressed alcoholics.
authors.affiliation: Department of Addiction, ASL CN2, Viale Coppino 46, 12051 Alba (CN), Italy. coppolamail@alice.it
authors.forename: M
authors.initials: M
authors.lastname: Coppola
authors.forename: R
authors.initials: R
authors.lastname: Mondola
mesh_terms: D000437:Alcoholism / Q000150:complications*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008962:Models, Theoretical; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; C578785:methoxydine; D010622:Phencyclidine