title: Arylation of aldehyde homoenolates with aryl bromides.
abstract: A mild palladium catalyzed coupling of reactive aldehyde homoenolates with aryl bromides is described. Aldehyde homoenolates are generated by ring opening of cyclopropanols via a C-C cleavage step. The coupling generates aldehyde products at room temperature in 59-93% yield.
authors.affiliation: Penn/Merck Laboratory for High-Throughput Experimentation, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
authors.forename: Kevin
authors.initials: K
authors.lastname: Cheng
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Walsh