title: DIALIGN at GOBICS--multiple sequence alignment using various sources of external information.
abstract: DIALIGN is an established tool for multiple sequence alignment that is particularly useful to detect local homologies in sequences with low overall similarity. In recent years, various versions of the program have been developed, some of which are fully automated, whereas others are able to accept user-specified external information. In this article, we review some versions of the program that are available through 'Göttingen Bioinformatics Compute Server'. In addition to previously described implementations, we present a new release of DIALIGN called 'DIALIGN-PFAM', which uses hits to the PFAM database for improved protein alignment. Our software is available through http://dialign.gobics.de/.
authors.affiliation: Department of Bioinformatics, University of Göttingen, Institute of Microbiology and Genetics, Goldschmidtstr. 1, 37077 Göttingen, Germany.
authors.forename: Layal
authors.initials: L
authors.lastname: Al Ait
authors.forename: Zaher
authors.initials: Z
authors.lastname: Yamak
authors.forename: Burkhard
authors.initials: B
authors.lastname: Morgenstern
mesh_terms: D000465:Algorithms; D020407:Internet; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA; D020539:Sequence Analysis, Protein; D012984:Software