title: Folic acid-functionalized magnetic ZnFe2O4 hollow microsphere core/mesoporous silica shell composite particles: synthesis and application in drug release.
abstract: A drug delivery system was designed by deliberately combining the useful functions into one entity, which was composed of magnetic ZnFe2O4 hollow microsphere as the core, and mesoporous silica with folic acid molecules as the outer shell. Amine groups coated magnetic ZnFe2O4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NH2) composite particles were first synthesized by a one-pot direct co-condensation method. Subsequently a novel kind of folic acid-functionalized magnetic ZnFe2O4 hollow microsphere core/mesoporous silica shell (MZHM-MSS-NHFA) composite particles were synthesized by conjugating folic acid as targeted molecule to MZHM-MSS-NH2. Ibuprofen, a well-known antiphlogistic drug, was used as a model drug to assess the loading and releasing behavior of the composite microspheres. The results show that the MZHM-MSS-NHFA system has the higher capacity of drug storage and good sustained drug-release property.
authors.affiliation: School of Petrochemical Engineering and Key Laboratory of Fine Petro-chemical Technology, Changzhou University, Changzhou, Jiangsu 213164, PR China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Yang
authors.forename: Kaiwei
authors.initials: K
authors.lastname: Wei
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.forename: Xue
authors.initials: X
authors.lastname: Guo
authors.forename: Hongren
authors.initials: H
authors.lastname: Rong
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Cheng
authors.forename: Guoxiu
authors.initials: G
authors.lastname: Wang
mesh_terms: D004337:Drug Carriers; D005290:Ferric Compounds / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry*; D008280:Magnetics; D046529:Microscopy, Electron, Transmission; D008863:Microspheres; D033362:Powder Diffraction; D012822:Silicon Dioxide / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D005290:Ferric Compounds; C000499:ferric oxide; D012822:Silicon Dioxide; D005492:Folic Acid; D015032:Zinc