title: Antiproliferative activity of 2,3-disubstituted indoles toward apoptosis-resistant cancers cells.
abstract: Many types of cancer, including glioma, melanoma, NSCLC, among others, are resistant to apoptosis induction and poorly responsive to current therapies with propaptotic agents. We describe a series of 2,3-disubstituted indoles, which display cytostatic rather than cytotoxic effects in cancer cells, and serve as a new chemical scaffold to develop anticancer agents capable of combating apoptosis-resistant cancers associated with dismal prognoses.
authors.affiliation: Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA. imagedov@nmt.edu
authors.forename: Igor V
authors.initials: IV
authors.lastname: Magedov
authors.forename: Florence
authors.initials: F
authors.lastname: Lefranc
authors.forename: Liliya V
authors.initials: LV
authors.lastname: Frolova
authors.forename: Laetitia Moreno Y
authors.initials: LM
authors.lastname: Banuls
authors.forename: Amanda S
authors.initials: AS
authors.lastname: Peretti
authors.forename: Snezna
authors.initials: S
authors.lastname: Rogelj
authors.forename: Véronique
authors.initials: V
authors.lastname: Mathieu
authors.forename: Robert
authors.initials: R
authors.lastname: Kiss
authors.forename: Alexander
authors.initials: A
authors.lastname: Kornienko
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles