title: Acute myeloid leukaemia in Western Australia 1991-2005: a retrospective population-based study of 898 patients regarding epidemiology, cytogenetics, treatment and outcome.
abstract: BACKGROUND
  Patient characteristics and cytogenetics of acute myeloid leukaemia (AML) in clinical trials do not reflect that of the general population. There has not been a large population-based study that has examined cytogenetic features and outcomes of AML in Australia.
  
  
  OBJECTIVE
  Investigation of epidemiological, prognostic, treatment and outcome data in adults diagnosed with AML in Western Australia between 1991 and 2005.
  
  
  METHODS
  Patients were identified utilising the Western Australia Cancer Registry, cytogenetic databases and hospital inpatient discharge diagnoses. Data were retrospectively collected from patients presenting to tertiary hospitals on patient characteristics, karyotype, induction therapy, remission, transplantation and survival.
  
  
  RESULTS
  A total of 987 patients with AML was identified, of which 91% (898) attended a tertiary hospital. Median age was 67 years and 45% of cases represented secondary AML. Cytogenetic analysis was available in 81% of patients. Frequent karyotypes were normal (38.8%), complex (13.8%) and -7/add(7q)/del(7q) (12.1%). Aggressive therapy was initiated in 62.6%. Less than 15% were enrolled in clinical trials. Overall 16.5% received a stem cell transplant. Median overall survival for all patients was 5.6 months. In patients treated aggressively, complete remission was achieved in 56.9% and median overall survival was 12.2 months. Age, secondary disease and karyotype were significantly predictive of remission and overall survival.
  
  
  CONCLUSIONS
  Age distribution, remission and survival rates were comparable with published population-based studies. High median age was reflected in the rate of secondary AML and trial eligibility. These findings highlight the need for prospective data collection.
authors.affiliation: Department of Haematology, Royal Perth Hospital, Perth, Australia. shane.gangatharan@gmail.com
authors.forename: S A
authors.initials: SA
authors.lastname: Gangatharan
authors.forename: C S
authors.initials: CS
authors.lastname: Grove
authors.forename: S
authors.initials: S
authors.lastname: P'ng
authors.forename: J
authors.initials: J
authors.lastname: O'Reilly
authors.forename: D
authors.initials: D
authors.lastname: Joske
authors.forename: M F
authors.initials: MF
authors.lastname: Leahy
authors.forename: T
authors.initials: T
authors.lastname: Threlfall
authors.forename: M P
authors.initials: MP
authors.lastname: Wright
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020732:Cytogenetic Analysis / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology* / Q000235:genetics* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods*; D012042:Registries; D012189:Retrospective Studies; D033581:Stem Cell Transplantation / Q000401:mortality / Q000639:trends; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome; D014904:Western Australia / Q000453:epidemiology; D055815:Young Adult
keywords: Western Australia; acute myeloid leukaemia; cytogenetics; karyotype; population study; survival