title: PhenoMiner: quantitative phenotype curation at the rat genome database.
abstract: The Rat Genome Database (RGD) is the premier repository of rat genomic and genetic data and currently houses >40 000 rat gene records as well as human and mouse orthologs, >2000 rat and 1900 human quantitative trait loci (QTLs) records and >2900 rat strain records. Biological information curated for these data objects includes disease associations, phenotypes, pathways, molecular functions, biological processes and cellular components. Recently, a project was initiated at RGD to incorporate quantitative phenotype data for rat strains, in addition to the currently existing qualitative phenotype data for rat strains, QTLs and genes. A specialized curation tool was designed to generate manual annotations with up to six different ontologies/vocabularies used simultaneously to describe a single experimental value from the literature. Concurrently, three of those ontologies needed extensive addition of new terms to move the curation forward. The curation interface development, as well as ontology development, was an ongoing process during the early stages of the PhenoMiner curation project. Database URL: http://rgd.mcw.edu.
authors.affiliation: Human and Molecular Genetics Center, Medical College of Wisconsin, Human and Molecular Genetics Center, 8701 Watertown Plank Rd, Milwaukee, WI 53226-3548, USA. slaulederkind@mcw.edu
authors.forename: Stanley J F
authors.initials: SJ
authors.lastname: Laulederkind
authors.forename: Weisong
authors.initials: W
authors.lastname: Liu
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Smith
authors.forename: G Thomas
authors.initials: GT
authors.lastname: Hayman
authors.forename: Shur-Jen
authors.initials: SJ
authors.lastname: Wang
authors.forename: Rajni
authors.initials: R
authors.lastname: Nigam
authors.forename: Victoria
authors.initials: V
authors.lastname: Petri
authors.forename: Timothy F
authors.initials: TF
authors.lastname: Lowry
authors.forename: Jeff
authors.initials: J
authors.lastname: de Pons
authors.forename: Melinda R
authors.initials: MR
authors.lastname: Dwinell
authors.forename: Mary
authors.initials: M
authors.lastname: Shimoyama
mesh_terms: D000818:Animals; D057225:Data Mining / Q000379:methods*; D030541:Databases, Genetic; D016678:Genome / Q000235:genetics*; D006801:Humans; D051379:Mice; D058977:Molecular Sequence Annotation; D010641:Phenotype; D051381:Rats; D012984:Software; D057188:Workflow