title: Influence of variants in the NPY gene on obesity and metabolic syndrome features in Spanish children.
abstract: Variants in the neuropeptide Y (NPY) gene have been associated with obesity and its traits. The objective of the present study was to evaluate the association of single nucleotide polymorphisms (SNPs) in the NPY gene with obesity, metabolic syndrome features, and inflammatory and cardiovascular disease (CVD) risk biomarkers in Spanish children. We recruited 292 obese children and 242 normal-body mass index (BMI) children. Height, weight, BMI, waist circumference, clinical and metabolic markers, adipokines, and inflammatory (PCR, IL-6, IL-8 and TNF-α) and CVD risk biomarkers (MPO, MMP-9, sE-selectin, sVCAM, sICAM, and PAI-1) were analyzed. Seven SNPs in the NPY gene were genotyped. The results of our study indicate that anthropometric measurements, clinical and metabolic markers, adipokines (leptin and resistin), and inflammatory and CVD risk biomarkers were generally elevated in the obese group. The exceptions to this finding included cholesterol, HDL-c, and adiponectin, which were lower in the obese group, and glucose, LDL-c, and MMP-9, which did not differ between the groups. Both rs16147 and rs16131 were associated with the risk of obesity, and the latter was also associated with insulin resistance, triacylglycerols, leptin, and HDL-c. Thus, we confirm the association of rs16147 with obesity, and we demonstrate for the first time the association of rs16131 with obesity and its possible impact on the early onset of metabolic syndrome features, mainly triacylglycerols, in children.
authors.affiliation: Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, University of Granada, Center of Biomedical Research, Laboratory 123, Avenida del Conocimiento s/n, 18016 Armilla, Granada, Spain. jolza@ugr.es
authors.forename: Josune
authors.initials: J
authors.lastname: Olza
authors.forename: Mercedes
authors.initials: M
authors.lastname: Gil-Campos
authors.forename: Rosaura
authors.initials: R
authors.lastname: Leis
authors.forename: Azahara I
authors.initials: AI
authors.lastname: Rupérez
authors.forename: Rafael
authors.initials: R
authors.lastname: Tojo
authors.forename: Ramón
authors.initials: R
authors.lastname: Cañete
authors.forename: Angel
authors.initials: A
authors.lastname: Gil
authors.forename: Concepción M
authors.initials: CM
authors.lastname: Aguilera
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood; D005260:Female; D060005:Genotyping Techniques; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology / Q000235:genetics; D009478:Neuropeptide Y / Q000097:blood / Q000235:genetics*; D009765:Obesity / Q000097:blood / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D052243:Resistin / Q000097:blood; D012307:Risk Factors; D013030:Spain; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D016207:Cytokines; D020738:Leptin; D009478:Neuropeptide Y; D052243:Resistin; D014280:Triglycerides