title: Feasibility of breast cancer screening by PIXE analysis of hair.
abstract: To reveal the role of key elements present in the hair of breast cancer patients on cancer development, the levels of a number of elements in scalp hair samples of 82 people including healthy individuals, people suffering from benign breast disease, and breast cancer patients were measured by PIXE analysis. Pellets of hair samples were prepared and bombarded by 2.2 MeV proton beam of a 3-MV Van de Graaff accelerator. The number of incident ions hitting the sample was indirectly measured using the RBS spectrum of a thin Ag film placed in the beam path. The concentrations of S, Cl, K, Ca, Fe, and Cu in the hair of healthy individuals were in agreement with those observed in the hair of hyperplasia and cancer patients within standard deviations. However, a lower average level of zinc was found in samples from hyperplasia and breast cancer patients. Strong positive correlations were found between iron and potassium as well as between calcium and potassium in the cancer patients. These results could be of significance in the screening for breast cancer.
authors.affiliation: Department of Physics, K. N. Toosi University of Technology, Tehran, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Gholizadeh
authors.forename: Z
authors.initials: Z
authors.lastname: Kabiri
authors.forename: O
authors.initials: O
authors.lastname: Kakuee
authors.forename: M
authors.initials: M
authors.lastname: Saleh-Kotahi
authors.forename: V
authors.initials: V
authors.lastname: Changizi
authors.forename: V
authors.initials: V
authors.lastname: Fathollahi
authors.forename: P
authors.initials: P
authors.lastname: Oliaiy
authors.forename: R
authors.initials: R
authors.lastname: Omranipour
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D016022:Case-Control Studies; D005240:Feasibility Studies; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans