title: Virological and immunological mechanisms in the pathogenesis of human T-cell leukemia virus type 1.
abstract: Human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus shown to cause human disease, such as adult T-cell leukemia and HTLV-1 associated myelopathy/tropic spastic paraparesis. HTLV-1 mainly infects CD4 T cells and deregulates their differentiation, function and homeostasis, which should contribute to the pathogenesis of HTLV-1, for example, inducing transformation of infected CD4 T cells and chronic inflammatory diseases. Therefore, not only virological approach but also immunological approach regarding CD4 T cells are required to understand how HTLV-1 causes related human diseases. This review focuses on recent advances in our understanding of the interaction between HTLV-1 and the main host cell, CD4 T cells, which should provide us some clue to the mechanisms of HTLV-1 mediated pathogenesis.
authors.affiliation: Laboratory for Virus Control, Institute for Virus Research, Kyoto University, Kyoto, Japan. y-satou@kumamoto-u.ac.jp
authors.forename: Yorifumi
authors.initials: Y
authors.lastname: Satou
authors.forename: Masao
authors.initials: M
authors.lastname: Matsuoka
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000502:physiology* / Q000821:virology*; D015490:HTLV-I Infections / Q000276:immunology* / Q000473:pathology*; D015368:Human T-lymphotropic virus 1 / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans