title: Is it worth investigating splenic function in patients with celiac disease?
abstract: Celiac disease, an immune-mediated enteropathy induced in genetically susceptible individuals by the ingestion of gluten, is the most frequent disorder associated with splenic hypofunction or atrophy. Defective splenic function affects more than one-third of adult patients with celiac disease, and it may predispose to a higher risk of infections by encapsulated bacteria and thromboembolic and autoimmune complications, particularly when celiac patients have concomitant pre-malignant and malignant complications (refractory celiac disease, ulcerative jejunoileitis and enteropathy-associated T-cell lymphoma). However, the clinical management of patients with celiac disease does not take into account the evaluation of splenic function, and in patients with high degree of hyposplenism or splenic atrophy the prophylactic immunization with specific vaccines against the polysaccharide antigens of encapsulated bacteria is not currently recommended. We critically re-evaluate clinical and diagnostic aspects of spleen dysfunction in celiac disease, and highlight new perspectives in the prophylactic management of infections in this condition.
authors.affiliation: Department of Internal Medicine, Celiac Centre, S. Matteo Hospital Foundation, University of Pavia, 27100 Pavia, Italy. a.disabatino@smatteo.pv.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Sabatino
authors.forename: Laura
authors.initials: L
authors.lastname: Brunetti
authors.forename: Gabriella
authors.initials: G
authors.lastname: Carnevale Maffè
authors.forename: Paolo
authors.initials: P
authors.lastname: Giuffrida
authors.forename: Gino Roberto
authors.initials: GR
authors.lastname: Corazza
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis; D001402:B-Lymphocytes / Q000166:cytology; D002446:Celiac Disease / Q000175:diagnosis* / Q000503:physiopathology; D004198:Disease Susceptibility / Q000503:physiopathology; D005983:Glutens / Q000378:metabolism; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism; D007156:Immunologic Memory; D022242:Pneumococcal Vaccines / Q000627:therapeutic use; D013154:Spleen / Q000503:physiopathology*; D013158:Splenic Diseases / Q000150:complications / Q000175:diagnosis; D050378:T-Lymphocytes, Regulatory / Q000166:cytology; D013923:Thromboembolism / Q000150:complications / Q000175:diagnosis
chemical_list: D007075:Immunoglobulin M; D022242:Pneumococcal Vaccines; D005983:Glutens
keywords: Hyposplenism; Memory B cell; Pitted red cell; Pneumococcal vaccine; Splenic atrophy