title: Chromatin modifications and chromatin remodeling during DNA repair in budding yeast.
abstract: Double-strand breaks (DSBs) pose a serious threat to genome integrity. Eukaryotes from yeast to humans respond to DSB damage by activating a complex DNA damage response that includes imposing a block to cell cycle progression and the repair of the DSB by one of several pathways. Many of these processes are accompanied by alterations in chromosome and chromatin structure. In this review we focus on the checkpoint responses and DNA repair in the well-studied model organism, the budding yeast Saccharomyces cerevisiae.
authors.affiliation: Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Waltham, MA 02454-9110, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Tsabar
authors.forename: James E
authors.initials: JE
authors.lastname: Haber
mesh_terms: D002843:Chromatin / Q000235:genetics* / Q000648:ultrastructure; D042002:Chromatin Assembly and Disassembly / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics* / Q000648:ultrastructure; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins