title: Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity.
abstract: Thirteen highly oxygenated daphnane diterpenoids, including six known compounds, were isolated from the stems of Trigonostemon lii. The structures were elucidated by extensive spectroscopic analyses including 2D NMR spectroscopy (HSQC, (1)H-(1)H COSY, HMBC, and ROESY) and mass spectrometry. The absolute stereochemistries of compounds were established on the basis of CD spectra. Four of the compounds showed modest anti-HIV-1 activity (EC50=2.04, 9.17, 11.42, and 9.05 μg/ml, TI=26.49, >21.81, 9.32, and 9.56, respectively) in vitro.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Shi-Fei
authors.initials: SF
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ning
authors.initials: N
authors.lastname: Huang
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Li
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Cheng
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019665:Euphorbiaceae / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018547:Plant Stems / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D004224:Diterpenes
keywords: Anti-HIV-1 activity; Daphnane diterpenoids; Euphorbiaceae; Trigolins A–G; Trigonostemon lii