title: Association of automated carotid IMT measurement and HbA1c in Japanese patients with coronary artery disease.
abstract: OBJECTIVE
  The purpose of this study was to evaluate whether carotid IMT (cIMT) identified using automated software is associated with HbA1c in Japanese patients with coronary artery disease.
  
  
  METHODS
  370 consecutive patients (males 218; median age 69 years ± 11) who underwent carotid-US and first coronary angiography were prospectively analyzed. After ultrasonographic examinations were performed, the plaque score (PS) was calculated and automated IMT analysis was obtained with a dedicated algorithm. Pearson correlation analysis was performed to calculate the association between automated IMT, PS and HbA1c.
  
  
  RESULTS
  The mean value of cIMT was 1.00 ± 0.47 mm for the right carotid and 1.04 ± 0.49 mm for the left carotid; the average bilateral value was 1.02 ± 0.43 mm. No significant difference of cIMT was detected between men and women. We found a direct correlation between cIMT values and HbA1c (p=0.0007) whereas the plaque score did not correlate with the HbA1c values (p>0.05) CONCLUSION: The results of our study confirm that automated cIMT values and levels of HbA1c in Japanese patients with coronary artery disease are correlated whereas the plaque score does not show a statistically significant correlation.
authors.affiliation: Department of Imaging Sciences, Azienda Ospedaliero Universitaria (A.O.U.) di Cagliari - Polo di Monserrato, Università di Cagliari, s.s. 554 Monserrato, Cagliari 09045, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Saba
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Ikeda
authors.forename: Martino
authors.initials: M
authors.lastname: Deidda
authors.forename: Tadashi
authors.initials: T
authors.lastname: Araki
authors.forename: Filippo
authors.initials: F
authors.lastname: Molinari
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Meiburger
authors.forename: U Rajendra
authors.initials: UR
authors.lastname: Acharya
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nagashima
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mercuro
authors.forename: Masataka
authors.initials: M
authors.lastname: Nakano
authors.forename: Andrew
authors.initials: A
authors.lastname: Nicolaides
authors.forename: Jasjit S
authors.initials: JS
authors.lastname: Suri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D059168:Carotid Intima-Media Thickness; D003324:Coronary Artery Disease / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human