title: Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger.
abstract: Little is known about resistance of Plasmodium falciparum to antimalarials in Sahelian countries. Here we investigated the drug susceptibilities of fresh isolates collected in Niger post-deployment of artemisinin-based combination therapies (ACTs). We found that the parasites remained highly susceptible to new (dihydroartemisinin, lumefantrine, pyronaridine, and piperaquine) and conventional (amodiaquine and chloroquine) antimalarial drugs. The introduction of ACTs in 2005 and their further deployment nationwide have therefore not resulted in a decrease in P. falciparum susceptibilities to these antimalarials.
authors.affiliation: Unité de Parasitologie, Centre de Recherche Médicale et Sanitaire, Niamey, Niger.
authors.forename: Mariama
authors.initials: M
authors.lastname: Issaka
authors.forename: Adamou
authors.initials: A
authors.lastname: Salissou
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Arzika
authors.forename: Julia
authors.initials: J
authors.lastname: Guillebaud
authors.forename: Abani
authors.initials: A
authors.lastname: Maazou
authors.forename: Sabine
authors.initials: S
authors.lastname: Specht
authors.forename: Halima
authors.initials: H
authors.lastname: Zamanka
authors.forename: Thierry
authors.initials: T
authors.lastname: Fandeur
mesh_terms: D000655:Amodiaquine / Q000627:therapeutic use; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use*; D037621:Artemisinins / Q000627:therapeutic use; D002738:Chloroquine / Q000627:therapeutic use; D004351:Drug Resistance; D004983:Ethanolamines / Q000627:therapeutic use; D005449:Fluorenes / Q000627:therapeutic use; D006801:Humans; D000078102:Lumefantrine; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology / Q000635:transmission; D009287:Naphthyridines / Q000627:therapeutic use; D009548:Niger; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification; D011804:Quinolines / Q000627:therapeutic use; D010879:Piperazines
chemical_list: D000655:Amodiaquine; D000962:Antimalarials; D037621:Artemisinins; D002738:Chloroquine; D004983:Ethanolamines; D005449:Fluorenes; D000078102:Lumefantrine; D009287:Naphthyridines; D011804:Quinolines; C039060:artenimol; C034759:piperaquine; D010879:Piperazines; C027871:pyronaridine