title: [Risk of gastric cancer dependent on serological markers of atrophic gastritis: cohort study].
abstract: In a prospective study the risk of subsequent gastric cancer (GC) was assessed in persons aged 45-69 over 5 years after the initial testing with a set of serological tests (pepsinogen I, pepsinogen II, gastrin-17, antibodies to Helicobacter pylori). The presence of gastric atrophy markers was a significant predictor of GC in the forthcoming years. Non-invasive techniques may be used in the formation of high-risk groups, followed by GC active surveillance.
authors.forename: O V
authors.initials: OV
authors.lastname: Reshetnikov
authors.forename: T G
authors.initials: TG
authors.lastname: Openko
authors.forename: G I
authors.initials: GI
authors.lastname: Simonova
authors.forename: S A
authors.initials: SA
authors.lastname: Kurilovich
authors.forename: S K
authors.initials: SK
authors.lastname: Maliushina
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Ragino
authors.forename: M I
authors.initials: MI
authors.lastname: Voevoda
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D005260:Female; D005755:Gastrins / Q000097:blood*; D005757:Gastritis, Atrophic / Q000097:blood* / Q000201:enzymology / Q000276:immunology / Q000382:microbiology; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood; D020115:Pepsinogen C / Q000097:blood; D010435:Pepsinogens / Q000097:blood*; D012189:Retrospective Studies; D012698:Serologic Tests; D013274:Stomach Neoplasms / Q000097:blood* / Q000201:enzymology / Q000276:immunology / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D005755:Gastrins; D010435:Pepsinogens; C013550:gastrin 17; D020115:Pepsinogen C; D020116:Pepsinogen A