title: Tea and non-tea flavonol intakes in relation to atherosclerotic vascular disease mortality in older women.
abstract: Epidemiological studies have indicated that dietary flavonoids generally, and flavonols specifically, may contribute to cardiovascular health. Tea consumption, which is often the main dietary source of flavonoids and flavonols, is associated with a reduced risk of cardiovascular outcomes. The primary objective of the present study was to explore the association of the habitual intake of flavonols from tea and non-tea sources with the risk of atherosclerotic vascular disease mortality in a population of elderly women. A total of 1063 women, aged over 75 years, were randomly selected from ambulant Caucasian women living in Perth, Western Australia. Flavonoid consumption was assessed using the US Department of Agriculture Flavonoid, Flavone and Proanthocyanidin databases. Atherosclerotic vascular disease mortality was assessed over 5 years of follow-up through the Western Australian Data Linkage System. During the follow-up, sixty-four women died from atherosclerotic vascular disease. Women in the highest compared with the lowest tertile of flavonol intake had a lower risk of atherosclerotic vascular disease death (OR 0·27, 95 % CI 0·13, 0·59; P≤ 0·01 for trend in multivariate-adjusted models). Similar relationships were observed for flavonol intake derived from both tea (OR 0·38, 95 % CI 0·18, 0·79; P< 0·01) and non-tea (OR 0·41, 95 % CI 0·20, 0·85; P= 0·05) sources. Tea was the main contributor to flavonol intake (65 %), and the intakes of flavonols from tea and non-tea sources were not significantly correlated. In conclusion, increased consumption of flavonols was independently associated with a lower risk of atherosclerotic vascular disease mortality. Both tea and non-tea sources of flavonols were independently associated with this benefit.
authors.affiliation: Sir Charles Gairdner Hospital Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, WA 6009, Australia.
authors.forename: Kerry L
authors.initials: KL
authors.lastname: Ivey
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Lewis
authors.forename: Richard L
authors.initials: RL
authors.lastname: Prince
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Hodgson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000401:mortality*; D028241:Camellia sinensis / Q000737:chemistry*; D004032:Diet; D005247:Feeding Behavior; D005260:Female; D044948:Flavonols / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D016017:Odds Ratio; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D012306:Risk; D014904:Western Australia / Q000453:epidemiology
chemical_list: D044948:Flavonols; D010936:Plant Extracts