title: Serum uric acid and metabolic risk.
abstract: OBJECTIVE
  This review presents the information available on the role of uric acid (UA) on metabolic risk and on the link between hyperuricemia and metabolic syndrome.
  
  
  METHODS
  Key papers for inclusion were identified by a PubMed search and articles were selected according to their relevance for the topic, according to the authors' judgment.
  
  
  CONCLUSIONS
  An elevated UA is both strongly associated and predictive of the metabolic syndrome, and increasing evidence suggests that UA may have a causal role. The classical viewpoint that UA is simply an innocuous marker of metabolic syndrome that should not even be measured will likely have to be modified. Lowering UA may be a novel treatment target for preventing diabetes and justify prospective clinical trials on the possible benefits of the measurement and lowering of serum UA on multiple chronic disease end points.
authors.affiliation: Université Paris 7, UFR médicale, Assistance Publique-Hôpitaux de Paris, Hôpital Lariboisière, Fédération de Rhumatologie, Paris, France. pascal.richette@lrb.aphp.fr
authors.forename: P
authors.initials: P
authors.lastname: Richette
authors.forename: F
authors.initials: F
authors.lastname: Perez-Ruiz
mesh_terms: D000818:Animals; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D008297:Male; D023421:Models, Animal; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid