title: An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.
abstract: Novel Psychoactive Drugs (NPD) can be sold without restriction and are often synthetic analogues of controlled drugs. The tryptamines are an important class of NPD as they bind to the various serotonin (5-HT) receptor subtypes and cause psychosis and hallucinations that can lead to injury or death through misadventure. Here we report on the structure elucidation and receptor binding profiles of two widely marketed tryptamine-derived NPDs, namely alpha-methyl-tryptamine and 5-methoxy-N,N-diallyl-tryptamine.
authors.affiliation: Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Warunya
authors.initials: W
authors.lastname: Arunotayanun
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Dalley
authors.forename: Xi-Ping
authors.initials: XP
authors.lastname: Huang
authors.forename: Vincent
authors.initials: V
authors.lastname: Setola
authors.forename: Ric
authors.initials: R
authors.lastname: Treble
authors.forename: Leslie
authors.initials: L
authors.lastname: Iversen
authors.forename: Bryan L
authors.initials: BL
authors.lastname: Roth
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
mesh_terms: D000498:Allyl Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D057809:HEK293 Cells; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011437:Propylamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011985:Receptors, Serotonin / Q000737:chemistry / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000138:chemical synthesis / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D014363:Tryptamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000498:Allyl Compounds; D007211:Indoles; D011437:Propylamines; D011619:Psychotropic Drugs; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; C578955:N,N-diallyl-5-methoxytryptamine