title: Synthesis, structure and in vitro cytotoxic studies of novel paramagnetic palladium(III) complexes with hematoporphyrin IX.
abstract: Two coordination compounds of Pd(III) with hematoporphyrin IX ((7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H-23H-porphyn-2,18-dipropionic acid), Hp), dinuclear [Pd(III)2(Hp-3H)Cl3(H2O)5]·2PdCl2, 1 and mononuclear [Pd(III)(Hp-2H)Cl(H2O)]·H2O, 2 were obtained and structurally characterized in solid state and solution using spectroscopic, thermal and magnetic methods. In the dinuclear complex, 1 one of the Pd(III) ions is coordinated to the deprotanated COO(-) groups from the side chains of the porphyrin ligand and the second Pd(III) ion - to two adjacent pyrrole N-atoms on the top of the porphyrin ring and a Pd(III)-Hp-Pd(III) system was formed. The Pd(III) ion in the mononuclear complex, 2 is incorporated in the porphyrin core. The Pd(III) centers in both complexes have a distorted octahedral coordination filled with additional donor species such as Cl(-) and H2O. The studied compounds showed in vitro cell growth inhibitory effects at micromolar concentration against a panel of human tumor cell lines. A DNA fragmentation assay indicated that the growth inhibitory effects are at least partly mediated by induction of apoptosis.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry and Pharmacy, University of Sofia, 1J. Bourchier Str., 1164 Sofia, Bulgaria.
authors.forename: Daniela
authors.initials: D
authors.lastname: Tsekova
authors.forename: Paulina
authors.initials: P
authors.lastname: Gorolomova
authors.forename: Georgi
authors.initials: G
authors.lastname: Gochev
authors.forename: Vassil
authors.initials: V
authors.lastname: Skumryev
authors.forename: Georgi
authors.initials: G
authors.lastname: Momekov
authors.forename: Denitsa
authors.initials: D
authors.lastname: Momekova
authors.forename: Galina
authors.initials: G
authors.lastname: Gencheva
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D053938:DNA Fragmentation / Q000187:drug effects*; D006415:Hematoporphyrins / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D010165:Palladium / Q000737:chemistry / Q000494:pharmacology; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology
chemical_list: D006415:Hematoporphyrins; D017319:Photosensitizing Agents; D010165:Palladium