title: Basal cell carcinoma arising from xeroderma pigmentosum: a case report and an immunohistochemical study.
abstract: We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163(+) M2 macrophages, together with Foxp3(+) regulatory T cells. Interestingly, MMP9, which was reported as one of the functional markers for immunosuppressive macrophages, was also detected in the CD163(+) M2 macrophage-infiltrated areas. Our case suggests the immunological background of tumor development in a patient with XP.
authors.affiliation: Department of Dermatology, Yamato Takada Municipal Hospital, Nara.
authors.forename: Sadanori
authors.initials: S
authors.lastname: Furudate
authors.forename: Taku
authors.initials: T
authors.lastname: Fujimura
authors.forename: Gen-Ichi
authors.initials: G
authors.lastname: Tojo
authors.forename: Takahiro
authors.initials: T
authors.lastname: Haga
authors.forename: Setsuya
authors.initials: S
authors.lastname: Aiba
keywords: Basal cell carcinoma; CD163+; Foxp3; M2 macrophages; Xeroderma pigmentosum