title: Renal transplantation with donors older than 70 years: does age matter?
abstract: OBJECTIVE
  The need for organs for renal transplantation has encouraged the use of grafts from increasingly older donors. Studies of transplantation results with donors older than 70 years are sparse. The main purpose of this study is to compare the results of transplantation with donors older and younger than 70 years old.
  
  
  METHODS
  This retrospective study included 1233 consecutive deceased-donor renal transplantations performed between January 1, 2001, and December 31, 2011. We compared outcomes of grafts from donors older than 70 years (group ≥ 70; n = 82) versus donors younger than 70 years (group < 70; n = 1151).
  
  
  RESULTS
  Univariate analysis of pretransplantation data showed statistically significant differences (P < .05) among the following variables for the group < 70 and group ≥ 70, respectively: recipient age (46 ± 13 versus 61 ± 5 years), donor age (44 ± 16 versus 73 ± 3 years), donor male gender (69.4% versus 47.6%), use of antibody induction immunosuppression (51.7% versus 70.7%), and HLA compatibilities (2.4 versus 2). The group ≥ 70 showed increased postoperative minor complications: bleeding (8.5% versus 3.4%; P = .017), lymphocele formation (3.7% versus 0.5%; P = .011), and incisional hernia (2.4% versus 0.2%; P < .001). Regarding transplantation results, we observed that mean serum creatinine was significantly lower among group < 70, at 1, 3, 6, 12, 24, and 60 months after transplantation (P < .05). Cumulative graft survival at 1, 3, and 4 years was 90%, 85%, and 83% in the group < 70 versus 87%, 79%, and 72% in the group ≥ 70. In the subgroup of recipients younger than 60 years, we did not verify statistically significant differences in allograft survival between group ≥ 70 and group < 70. Using Cox regression for survival analysis, we verified that donor age was not an independent risk factor for graft failure.
  
  
  CONCLUSIONS
  The group of patients who received kidneys from donors younger than 70 years achieved better transplantation outcomes. Nevertheless, kidneys from older donors represent an excellent alternative for older recipients.
authors.affiliation: Urology and Renal Transplantation Department, Coimbra University Hospital, Coimbra, Portugal.
authors.forename: L
authors.initials: L
authors.lastname: Marconi
authors.forename: A
authors.initials: A
authors.lastname: Figueiredo
authors.forename: L
authors.initials: L
authors.lastname: Campos
authors.forename: P
authors.initials: P
authors.lastname: Nunes
authors.forename: A
authors.initials: A
authors.lastname: Roseiro
authors.forename: B
authors.initials: B
authors.lastname: Parada
authors.forename: A
authors.initials: A
authors.lastname: Mota
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002102:Cadaver; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies