title: The opposite effect of isotype-selective monoamine oxidase inhibitors on adipogenesis in human bone marrow mesenchymal stem cells.
abstract: Adiponectin production during adipocyte differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) can be used to evaluate the pharmacological activity of anti-diabetic drugs to improve insulin sensitivity. Monoamine oxidase (MAO) inhibitors such as phenelzine and pargyline inhibit adipogenesis in murine pre-adipocytes. In this study, however, we found that selective MAO-A inhibitors, moclobemide and Ro41-1049, and a selective MAO-B inhibitor, selegiline, promoted adiponectin production during adipocyte differentiation in hBM-MSCs, which suggested the anti-diabetic potential of these drugs. In contrast, non-selective MAO inhibitors, phenelzine and tranylcypromine, inhibited adipocyte differentiation of hBM-MSCs. Concomitant treatments of MAO-A and MAO-B selective inhibitors did not change the stimulatory effect on adiponectin production in hBM-MSCs. Taken together, the opposite effects of isotype-selective MAO inhibitors on adiponectin production during adipogenesis in hBM-MSCs may not be directly associated with the inhibitory effects of MAO, suggested that the structure of MAO inhibitors may contain a novel anti-diabetic pharmacophore.
authors.affiliation: College of Pharmacy, Korea University, 2511 Sejong-ro, Sejong, Republic of Korea.
authors.forename: Youngjoo
authors.initials: Y
authors.lastname: Byun
authors.forename: Jongho
authors.initials: J
authors.lastname: Park
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Hong
authors.forename: Mi Hwa
authors.initials: MH
authors.lastname: Han
authors.forename: Suzie
authors.initials: S
authors.lastname: Park
authors.forename: Hyo-Il
authors.initials: HI
authors.lastname: Jung
authors.forename: Minsoo
authors.initials: M
authors.lastname: Noh
mesh_terms: D041721:3T3-L1 Cells; D050156:Adipogenesis / Q000187:drug effects; D000818:Animals; D050034:Antidiuretic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000166:cytology*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D051379:Mice; D008995:Monoamine Oxidase / Q000737:chemistry* / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010624:Phenelzine / Q000737:chemistry / Q000494:pharmacology; D014191:Tranylcypromine / Q000737:chemistry / Q000494:pharmacology
chemical_list: D050034:Antidiuretic Agents; D008996:Monoamine Oxidase Inhibitors; D014191:Tranylcypromine; D008995:Monoamine Oxidase; D010624:Phenelzine