title: Small intestinal tubular adenoma in a pediatric patient with Turner syndrome.
abstract: Turner syndrome (TS) is a female chromosomal disorder caused by the lack of an X chromosome. The loss of this chromosome may result in the deficiency of tumor-suppressive or DNA repair genes, leading to tumorigenesis. Recombinant human growth hormone (GH) has been popularly used for treatment in TS patients for growth promotion. Although treatment with GH has been correlated with precancerous and cancerous lesions in TS children, its associations with gastric or colonic tumors, especially ileal tubular adenomas, have not been reported frequently. We here report a case of a 16-year-old patient with TS and tubular adenoma of the small intestine. Whether the ileal adenoma was caused by TS itself or GH therapy was discussed.
authors.affiliation: Department of Gastroenterology of Fudan University Children's Hospital, Shanghai 201102, China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Tang
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Lian
authors.initials: L
authors.lastname: Chen
authors.forename: Shan
authors.initials: S
authors.lastname: Zheng
authors.forename: Kui-Ran
authors.initials: KR
authors.lastname: Dong
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging; D000236:Adenoma / Q000150:complications* / Q000175:diagnosis* / Q000601:surgery; D000293:Adolescent; D003113:Colonoscopy / Q000379:methods; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014424:Turner Syndrome / Q000150:complications* / Q000175:diagnosis*; D014463:Ultrasonography
chemical_list: D019382:Human Growth Hormone
keywords: Growth hormone; Ileocolonoscopy; Pediatric patient; Tubular adenoma; Turner syndrome