title: The therapeutic potential of IGF-I in skeletal muscle repair.
abstract: Skeletal muscle loss due to aging, motor-neuron degeneration, cancer, heart failure, and ischemia is a serious condition for which currently there is no effective treatment. Insulin-like growth factor 1 (IGF-I) plays an important role in muscle maintenance and repair. Preclinical studies have shown that IGF-I is involved in increasing muscle mass and strength, reducing degeneration, inhibiting the prolonged and excessive inflammatory process due to toxin injury, and increasing the proliferation potential of satellite cells. However, clinical trials have not been successful due to ineffective delivery methods. Choosing the appropriate isoforms or peptides and developing targeted delivery techniques can resolve this issue. Here we discuss the latest development in the field with special emphasis on novel therapeutic approaches.
authors.affiliation: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou 215123, China. yaohua_song1@yahoo.com
authors.forename: Yao-Hua
authors.initials: YH
authors.lastname: Song
authors.forename: Jenny L
authors.initials: JL
authors.lastname: Song
authors.forename: Patrice
authors.initials: P
authors.lastname: Delafontaine
authors.forename: Michael P
authors.initials: MP
authors.lastname: Godard
mesh_terms: D000818:Animals; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D012038:Regeneration / Q000502:physiology; D032496:Satellite Cells, Skeletal Muscle / Q000378:metabolism
chemical_list: D007334:Insulin-Like Growth Factor I