title: Primary cutaneous mantle cell lymphoma of the leg with blastoid morphology and aberrant immunophenotype: a diagnostic challenge.
abstract: Mantle cell lymphoma rarely affects the skin and is usually a secondary involvement. The present case illustrates a primary cutaneous mantle cell lymphoma of the leg, with blastoid morphology and aberrant expression of CD10 and bcl-6, which was misinterpreted at the beginning as diffuse large B-cell lymphoma. A larger panel of immunohistochemical markers, including cyclin-D1, and molecular investigation showing the typical translocation (t11;14), pointed toward the correct diagnosis. Cutaneous diffuse B-cell lymphomas with unusual morphology should be interpreted cautiously, and the diagnosis made on the basis of an appropriate panel of antibodies and molecular studies.
authors.affiliation: Department of Anatomic Pathology, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Cesinaro
authors.forename: Stefania
authors.initials: S
authors.lastname: Bettelli
authors.forename: Livia
authors.initials: L
authors.lastname: Maccio
authors.forename: Marina
authors.initials: M
authors.lastname: Milani
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D004268:DNA-Binding Proteins / Q000032:analysis / Q000096:biosynthesis; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D007866:Leg / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis*; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D015260:Neprilysin / Q000032:analysis / Q000096:biosynthesis; D051560:Proto-Oncogene Proteins c-bcl-6; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D014178:Translocation, Genetic
chemical_list: C084103:BCL6 protein, human; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; D015260:Neprilysin