title: It's the peptide-MHC affinity, stupid.
abstract: Adoptively transferred T cells can reject large established tumors, but recurrence due to escape variants frequently occurs. In this issue of Cancer Cell, Engels et al. demonstrate that the affinity of the target peptide to the MHC molecule determines whether large tumors will relapse following adoptive T cell therapy.
authors.affiliation: Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kammertoens
authors.forename: Thomas
authors.initials: T
authors.lastname: Blankenstein