title: Zeolitic imidazolate framework-8 as sorbent of micro-solid-phase extraction to determine estrogens in environmental water samples.
abstract: A novel micro-solid-phase extraction (μ-SPE) device coupled with ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) was established to determine five typical estrogens in aqueous samples. Zeolitic imidazolate framework-8 (ZIF-8) as sorbent was packed in polypropylene membrane to construct the μ-SPE device. Important extraction parameters including extraction time, extraction temperature, desorption solvent, desorption time and sample pH were carefully optimized to improve the extraction efficiency of the μ-SPE device. ZIF-8 sorbent showed an exceptional chemical stability and extraction efficiency for estrogens. In theory, the high extraction efficiencies may be due to the coordination bonding, intermolecular π-π interactions and hydrophobic interactions between ZIF-8 and the estrogens. Under the most favorable extraction conditions, for estrogens in aqueous samples, the proposed method provided low limits of detection (0.05-0.1μg/L), wide linearity range (three orders), excellent correlation coefficients (0.959-0.999) and satisfactory measurement precision (4.9-9.2%). which can meet the demand of determining estrogens at the trace level. Finally, the proposed method was successfully applied to determine the estrogens in real sewage water samples.
authors.affiliation: Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China. mgflora@hhu.edu.cn
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Wang
authors.forename: Shaoge
authors.initials: S
authors.lastname: Jin
authors.forename: Qiuying
authors.initials: Q
authors.lastname: Wang
authors.forename: Guanghua
authors.initials: G
authors.lastname: Lu
authors.forename: Jingjing
authors.initials: J
authors.lastname: Jiang
authors.forename: Dunru
authors.initials: D
authors.lastname: Zhu
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004967:Estrogens / Q000032:analysis* / Q000302:isolation & purification; D007093:Imidazoles / Q000737:chemistry*; D057230:Limit of Detection; D015203:Reproducibility of Results; D012722:Sewage / Q000737:chemistry; D052616:Solid Phase Extraction / Q000295:instrumentation* / Q000379:methods*; D053719:Tandem Mass Spectrometry; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000302:isolation & purification; D017641:Zeolites / Q000737:chemistry*
chemical_list: D004967:Estrogens; D007093:Imidazoles; D012722:Sewage; D014874:Water Pollutants, Chemical; D017641:Zeolites