title: [EB virus-associated lymphoproliferative disorders and cytokine storm].
abstract: Epstein-barr virus (EBV)-associated lymphoproliferative disorders (EBV-LPD) include a series of diseases from chronic to aggressive EBV-positive T-cells, NK cells, T/NK cells or B-cell LPD. The occurrence and development of EBV-LPD are closely associated with the cytokine storm, the clinical manifestations are very complex. Studies found that the different types of EBV-LPD express different cytokine secretion patterns, which help to further understand the progression of diseases, thus the EBV-LPD can be diagnosed early and treated early. In this article, different cytokine secretion patterns and their roles in EBV-LPD progression are reviewed. The main problems discussed above are the classification of EBV-LPD, T/NK-LPD and cytokine, B-LPD and cytokine, HLH and cytokine, and so on.
authors.affiliation: Department of Hematology, Peking University First Hospital, Beijing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
mesh_terms: D016207:Cytokines / Q000276:immunology*; D018450:Disease Progression; D020031:Epstein-Barr Virus Infections / Q000276:immunology*; D004854:Herpesvirus 4, Human; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000276:immunology / Q000821:virology*
chemical_list: D016207:Cytokines