title: Is the prevalence of pre-eclampsia affected by HIV/AIDS? A retrospective case-control study.
abstract: OBJECTIVE
  To evaluate the rate of HIV/AIDS (and CD4 levels) in women with pre-eclampsia compared to that of a control group.
  
  
  METHODS
  This was a retrospective case-control study in a tertiary and regional hospital in South Africa. We reviewed the hospital records of women who had delivered in these hospitals between 1 January 2008 and 30 June 2010. The records of women with pre-eclampsia during the study period were analysed. Their HIV infection rate was compared to that of a control group consisting of normotensive healthy pregnant women.
  
  
  RESULTS
  Among 492 cases of pre-eclampsia, 130 (26.4%) were HIV infected. In the control group, 183/500 (36.6%) were HIV infected (p = 0.001, OR = 0.62, 95% CI: 0.47-0.82). After adjustment to match the difference in maternal age and parity, the rate of HIV/AIDS was lower in the pre-eclamptic group than in the control group (p = 0.005, OR = 0.658).
  
  
  CONCLUSIONS
  The rate of HIV/AIDS was significantly lower in women with pre-eclampsia than in normotensive healthy pregnant women.
authors.affiliation: Department of Obstetrics and Gynaecology, Pietermaritzburg Complex of Academic Hospitals; Women's Health and HIV Research Group, Department of Obstetrics and Gynaecology, University of KwaZulu-Natal, Durban, South Africa. vitakal@yahoo.fr
authors.forename: V M S
authors.initials: VM
authors.lastname: Kalumba
authors.forename: J
authors.initials: J
authors.lastname: Moodley
authors.forename: T D
authors.initials: TD
authors.lastname: Naidoo
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D016009:Chi-Square Distribution; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D016015:Logistic Models; D016017:Odds Ratio; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D011247:Pregnancy; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013019:South Africa / Q000453:epidemiology; D062606:Tertiary Care Centers; D013997:Time Factors; D055815:Young Adult