title: Iridium-catalyzed enantioselective hydrogenation of unsaturated heterocyclic acids.
abstract: Spiral binding: A highly enantioselective hydrogenation of unsaturated heterocyclic acids has been developed by using chiral iridium/spirophosphino oxazoline catalysts (see scheme; BArF(-) =tetrakis[3,5-bis(trifluoromethyl)phenyl]borate, Boc=tert-butoxycarbonyl). This reaction provided an efficient method for the preparation of optically active heterocyclic acids with excellent enantioselectivities.
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Song
authors.initials: S
authors.lastname: Song
authors.forename: Shou-Fei
authors.initials: SF
authors.lastname: Zhu
authors.forename: Liu-Yang
authors.initials: LY
authors.lastname: Pu
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Zhou
mesh_terms: D000147:Acids, Heterocyclic; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000147:Acids, Heterocyclic; D007495:Iridium