title: Rare, germline mutation of KIT with imatinib-resistant multiple GI stromal tumors and mastocytosis.
authors.affiliation: Department of Gastroenterology, RVI, Queen Victoria Rd, Newcastle upon Tyne NE1 4LP, United Kingdom. Allyspeight@doctors.org.uk
authors.forename: Richard A
authors.initials: RA
authors.lastname: Speight
authors.forename: Annette
authors.initials: A
authors.lastname: Nicolle
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Needham
authors.forename: Mark W
authors.initials: MW
authors.lastname: Verrill
authors.forename: Jane
authors.initials: J
authors.lastname: Bryon
authors.forename: Simon
authors.initials: S
authors.lastname: Panter
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000032:analysis; D019008:Drug Resistance, Neoplasm; D005091:Exons; D005770:Gastrointestinal Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D046152:Gastrointestinal Stromal Tumors / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D018095:Germ-Line Mutation; D006801:Humans; D000068877:Imatinib Mesylate; D007150:Immunohistochemistry; D007421:Intestine, Small / Q000473:pathology / Q000601:surgery; D008297:Male; D008415:Mastocytosis / Q000150:complications / Q000235:genetics*; D010879:Piperazines / Q000494:pharmacology*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis / Q000235:genetics*; D011743:Pyrimidines / Q000494:pharmacology*; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D014408:Biomarkers, Tumor; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit