title: [Cardiac autonomic modulation in healthy subjects with a family history of chronic kidney disease].
abstract: BACKGROUND
  The positive family history of chronic kidney disease (FH+) is a risk factor for the appearance and development of this disease. Thus, it is important to assess traits that may be related to familial predisposition to chronic kidney disease.
  
  
  OBJECTIVE
  To evaluate the autonomic modulation by heart rate variability in individuals with FH+.
  
  
  METHODS
  We studied 9 health subjects with FH+ and 22 health subjects with negative family history for chronic kidney disease (FH-) matched for age (27 ± 6 vs. 26 ± 4 anos; p = 0.39, respectively). Heart rate was measured continuously by the Polar S810i® for 10 minutes of rest in the supine position. The heart rate variability was evaluated by the time domain, mean of NN intervals (MNN), standard deviation of the NN intervals (SDNN), root mean squared differences of successive NN intervals (RMSSD) and percentage of NN intervals with a difference of duration greater than 50 ms (pNN50) and the fields of low frequency (LF), high frequency (HF) and ratio low/ high (LF/HF). Laboratory biochemical tests were performed after fasting for 12 hours. Results are expressed as mean ± standard deviation, adopting as significant p < 0.05.
  
  
  RESULTS
  The groups FH+ and FH-were similar in serum creatinine (p = 0.98), estimated glomerular filtration rate (p = 0.49) and heart rate (p = 0.68). The groups FH+ and FH- showed no significant differences in relation to indices of heart rate variability MNN; SDNN; RMSSD; pNN50; Total power; LF; HF and LF/HF ration, respectively.
  
  
  CONCLUSIONS
  These findings suggest that the cardiac autonomic modulation is preserved in health subjects with HF+.
authors.affiliation: University Hospital and Faculty of Physical Education and Sports of the Federal University of Juiz de Fora.
authors.forename: Lívia Victorino de
authors.initials: LV
authors.lastname: Souza
authors.forename: Pedro Augusto de Carvalho
authors.initials: PA
authors.lastname: Mira
authors.forename: Isabelle Magalhães Guedes
authors.initials: IM
authors.lastname: Freitas
authors.forename: Natália Portela
authors.initials: NP
authors.lastname: Pereira
authors.forename: Jorge Roberto Perrout de
authors.initials: JR
authors.lastname: Lima
authors.forename: Marcus Gomes
authors.initials: MG
authors.lastname: Bastos
authors.forename: Mateus Camaroti
authors.initials: MC
authors.lastname: Laterza
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D051436:Renal Insufficiency, Chronic / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult