title: Genetic background of ochratoxin A production inPenicillium.
abstract: A part of the gene cluster responsible for the production of ochratoxin A inP. nordicum has been characterised recently. The analysed DNA region contains three putative genes: an alcaline proteinase (aspPN), a non-ribosomal peptide synthetase (npsPN) and an polyketide synthase (otapksPN). The last two genes are putative genes of the ochratoxin A biosynthetic pathway. Interestingly theotapksPN gene is present in this form only inP. nordicum but not inP. verrucosum indicating genetic differences between both ochratoxin A producingPenicillium species. The genes in ochratoxin A producingAspergillus species seems to be completely different. It has been demonstrated that thenpsPN gene is actively transcribed inP. nordicum under ochratoxin A producing conditions, indicating that this gene is involved in ochratoxin A biosynthesis.
authors.affiliation: Federal Research Centre for Nutrition and Food, Location Karisruhe, Haid-und-Neu-Str. 9, D-76131, Karisruhe.
authors.forename: A
authors.initials: A
authors.lastname: Karolewiez
authors.forename: C
authors.initials: C
authors.lastname: Bogs
authors.forename: R
authors.initials: R
authors.lastname: Geisen