title: What's your age again? Determination of human neutrophil half-lives revisited.
abstract: Neutrophils are the most abundant white blood cells and are indispensable for host defense. Recently, they have also been implicated in immune regulation and suppression. The latter functions seem hard to reconcile with the widely held view that neutrophils are very short-lived, with a circulatory half-life of <7 h. To reopen the discussion on the average neutrophil half-life, we review and discuss experiments performed in the 1950s, 1960s, and 1970s, as well as recent in vivo labeling experiments. We reappraise the current knowledge on neutrophil half-lives, including their production in the bone marrow, their residency in the circulation and marginated pool, and their exit from the circulation.
authors.affiliation: 1.University Medical Center Utrecht, HP. E 03.511, Heidelberglaan 100, 3584CX Utrecht, The Netherlands. l.koenderman@umcutrecht.nl.
authors.forename: Tamar
authors.initials: T
authors.lastname: Tak
authors.forename: Kiki
authors.initials: K
authors.lastname: Tesselaar
authors.forename: Janesh
authors.initials: J
authors.lastname: Pillay
authors.forename: José A M
authors.initials: JA
authors.lastname: Borghans
authors.forename: Leo
authors.initials: L
authors.lastname: Koenderman
mesh_terms: D001854:Bone Marrow Cells / Q000166:cytology; D002453:Cell Cycle; D016922:Cellular Senescence; D006207:Half-Life; D006706:Homeostasis; D006801:Humans; D009504:Neutrophils / Q000166:cytology*
keywords: PMN; bone marrow; granulopoiesis; labeling; lifespan; marginated pool