title: Does acute primary angle-closure cause an increased choroidal thickness?
abstract: OBJECTIVE
  We compared the choroidal thickness of the eyes of patients with acute primary angle-closure (APAC) with fellow eyes in the same patients.
  
  
  METHODS
  The analysis included 21 participants with unilateral APAC affected eyes and 21 fellow eyes with a diagnosis of primary angle-closure suspect (PACS). Enhanced depth imaging-optical coherence tomography (EDI-OCT) was used to measure the macular and peripapillary retinal and choroidal thickness in both eyes. The average choroidal thickness of the APAC eyes at each location or segment was compared to that of the fellow eyes.
  
  
  RESULTS
  At all macular locations, the choroidal thickness was greatest at the subfovea for both groups. Comparison of the choroidal thickness between the groups showed that the thickness in the APAC eyes was significantly greater than in the PACS eyes at all locations except at 1 mm, 3 mm superior, 3 mm inferior, and 3 mm temporal from the fovea (P < 0.005). The mean subfoveal choroidal thickness was 349.0 ± 78.1 μm in the APAC eyes and 308.1 ± 70.5 μm in the PACS eyes, with a statistically significant difference (P < 0.005). Multivariable linear regression analysis showed that the subfoveal choroidal thickness was significantly greater in association with the APAC diagnosis and diastolic blood pressure and thinner in association with older subjects.
  
  
  CONCLUSIONS
  APAC eyes have a higher level of macular choroidal thickness than PACS eyes when the IOP is reduced. However, the source of this difference is unclear and must be investigated further.
authors.affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Minwen
authors.initials: M
authors.lastname: Zhou
authors.forename: Wenbin
authors.initials: W
authors.lastname: Huang
authors.forename: Shida
authors.initials: S
authors.lastname: Chen
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Ding
authors.forename: Xiulan
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002829:Choroid / Q000473:pathology* / Q000503:physiopathology; D015862:Choroid Diseases / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000150:complications* / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012044:Regression Analysis; D041623:Tomography, Optical Coherence
keywords: acute primary angle-closure; choroidal thickness; primary angle-closure suspect