title: Inactivation of food-borne viruses using natural biochemical substances.
abstract: Food-borne viruses such as human Noroviruses (NoVs), hepatitis A virus (HAV), Rotaviruses (RoVs) are a public health concern worldwide. Biochemical substances, which occur naturally in plants, animals or microorganisms, might possess considerable antimicrobial properties. In this study, the reported effects of biochemical substances on food-borne viruses are reviewed. The biochemical substances are grouped into several categories including (i) polyphenols and proanthocyanins, (ii) saponin, (iii) polysaccharides, (iv) organic acids, (v) proteins and polypeptides, (vi) essential oils. Although not fully understood, the mechanism of action for the antiviral activity of the natural compounds is presented. Generally, it is thought to be the prevention of the viral attachment to host cells, either by causing damage on the viral capsids or change of the receptors on the cell membranes. It is recommended that further studies are undertaken not only on the wide-range screening for novel antiviral substances, but also on the mechanism in-depth as well as the exploration for their potential application in controlling virus contamination in foods or food processing.
authors.affiliation: Laboratory of Food Microbiology and Food Preservation, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium. Dan.Li@UGent.be
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Leen
authors.initials: L
authors.lastname: Baert
authors.forename: Mieke
authors.initials: M
authors.lastname: Uyttendaele
mesh_terms: D000872:Anthocyanins / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D001688:Biological Products / Q000494:pharmacology*; D005506:Food Contamination / Q000517:prevention & control*; D005516:Food Microbiology / Q000379:methods; D030041:Hepatitis A virus / Q000187:drug effects* / Q000254:growth & development; D029322:Norovirus / Q000187:drug effects* / Q000254:growth & development; D009822:Oils, Volatile / Q000494:pharmacology; D059808:Polyphenols / Q000494:pharmacology; D011134:Polysaccharides / Q000494:pharmacology; D012401:Rotavirus / Q000187:drug effects* / Q000254:growth & development; D012503:Saponins / Q000494:pharmacology
chemical_list: D000872:Anthocyanins; D000998:Antiviral Agents; D001688:Biological Products; D009822:Oils, Volatile; D059808:Polyphenols; D011134:Polysaccharides; D012503:Saponins