title: [Transmission and prevalence patterns of C4a evolutionary lineage of human enterovirus 71 circulating in mainland China, 2008-2010].
abstract: OBJECTIVE
  To understand the evolutionary relationship between the C4a evolutionary lineage of human enterovirus 71 (HEV71) strains circulating in mainland of China during 2008-2010 and 2008 Fuyang strains and study the prevalence and transmission patterns of 2008 Fuyang strains.
  
  
  METHODS
  Download all the complete VP1 ( > or = 891 bp) or approximate complete VP1 (> or = 876 bp) gene nucleotide sequences from GenBank of HEV71 strains circulating in Mainland of China during 2008-2010. And analyze the phylogenetic relationship between Fuyang strains and other provinces' strains using the MEGA software, version 5.0.
  
  
  RESULTS
  All of the HEV71 isolates circulating in Mainland of China during 2008-2010 were clustered into evolutionary lineage C4a except for eight strains grouped in the genotype A and one isolate belongs to evolutionary lineage C4b; the homology analysis showed there were 96.5%-100% identity between C4a viruses circulating in mainland China during 2008-2010 and 2008 Fuyang strains, and they were evolved from C4b viruses of 1998. The transmission chains of Fuyang strains were mainly transmitted in Guangdong, Jiangsu, Shanghai, Hunan, Shandong provinces.
  
  
  CONCLUSIONS
  The predominant viruses circulating in Mainland of China during 2008-2010 were evolutionary lineage C4a of human Enterovirus 71; Fuyang transmission chains mainly distributed in southern of China and the Central China around Anhui provinces.
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Zhou
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhu
authors.forename: Nai-Ying
authors.initials: NY
authors.lastname: Mao
authors.forename: Song-Tao
authors.initials: ST
authors.lastname: Xu
authors.forename: Ai-Li
authors.initials: AL
authors.lastname: Cui
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Tan
authors.forename: Shuang-Li
authors.initials: SL
authors.lastname: Zhu
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Yan
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Kongg
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Xu
mesh_terms: D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D029821:Enterovirus A, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins