title: Granulocyte colony-stimulating factor (G-CSF): a mediator in endometrial receptivity for a patient with polycystic ovary (PCO) undergoing in vitro maturation (IVM).
abstract: Proliferative and secretory changes at the endometrial lining are the result of a complex intrauterine environment where sex steroid hormones and different local factors play an important role for endometrial thickening. Optimal endometrial thickness reflects an adequate maturation which is a key factor for embryo implantation. Here, we present a case of a woman with polycystic ovary who was treated using in vitro maturation (IVM) techniques. In addition, this patient showed a dyssynchrony between the endometrial phase characterised by endometrial thinning and the embryo development which had a negative impact for embryo implantation. A protocol using uterine perfusion of granulocyte colony-stimulating factor (G-CSF) was performed as an alternative treatment for the unresponsive endometrium. We found that uterine infusion of G-CSF quickly increased endometrial thickness resulting in a successful pregnancy and healthy born baby. These results suggest that G-CSF is a factor that participates during endometrial remodelling enhancing the synchronisation between uterine environment and embryo development.
authors.affiliation: Scientific Chief Department, Fertility and Sterility Colombian Center, Bogota DC, Colombia.
authors.forename: Elkin
authors.initials: E
authors.lastname: Lucena
authors.forename: Harold
authors.initials: H
authors.lastname: Moreno-Ortiz
mesh_terms: D000328:Adult; D004717:Endometrium / Q000187:drug effects*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D016179:Granulocyte Colony-Stimulating Factor