title: Daunomycin-TFO Conjugates for Downregulation of Gene Expression.
abstract: Daunomycin has shown interesting properties as a stabilizing agent for the antigene methodology.This approach consists of targeting a polypurine region of a given gene, with a triplex formingoligonucleotide (TFO), realizing a triple helix complex (triplex), with the aim of down-regulatinggene expression. This chapter describes the basic principles of the triplex approach, the chemistry underliningthe binding of daunomycin to oligonucleotides, and some results of gene-inhibition obtained with daunomycin-TFOconjugates with different targets.
authors.affiliation: ISOF-CNR, Via Gobetti 101, 40129, Bologna, Italy, capobianco@isof.cnr.it.
authors.forename: Massimo L
authors.initials: ML
authors.lastname: Capobianco
authors.forename: Carlo V
authors.initials: CV
authors.lastname: Catapano