title: Circadian clocks and metabolism.
abstract: Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals, circadian integration of metabolic systems optimizes energy harvesting and utilization across the light/dark cycle. Disruption of clock genes has recently been linked to sleep disorders and to the development of cardiometabolic disease. Conversely, aberrant nutrient signaling affects circadian rhythms of behavior. This chapter reviews the emerging relationship between the molecular clock and metabolic systems and examines evidence that circadian disruption exerts deleterious consequences on human health.
authors.affiliation: Department of Medicine, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Lurie 7-107, Chicago, IL 60611, USA.
authors.forename: Biliana
authors.initials: B
authors.lastname: Marcheva
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Ramsey
authors.forename: Clara B
authors.initials: CB
authors.lastname: Peek
authors.forename: Alison
authors.initials: A
authors.lastname: Affinati
authors.forename: Eleonore
authors.initials: E
authors.lastname: Maury
authors.forename: Joseph
authors.initials: J
authors.lastname: Bass
mesh_terms: D000818:Animals; D057906:Circadian Clocks / Q000502:physiology*; D002940:Circadian Rhythm; D006801:Humans; D008027:Light; D051379:Mice; D009243:NAD / Q000378:metabolism; D010641:Phenotype; D011110:Polymorphism, Genetic; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; D009243:NAD