title: Resistant to thrombosis, induced stroke and heart arrest by incorporation of a single gene of PGI2-synthesizing COX-1-PGIS in vivo: Implication against human heart disease.
authors.affiliation: Centre for Experimental Therapeutics and Pharmacoinformatics, Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA. Electronic address: khruan@uh.edu.
authors.forename: Ke-He
authors.initials: KH
authors.lastname: Ruan
authors.forename: Anita J
authors.initials: AJ
authors.lastname: Mohite
authors.forename: Shui-Ping
authors.initials: SP
authors.lastname: So
mesh_terms: D000818:Animals; D051545:Cyclooxygenase 1 / Q000096:biosynthesis*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D011464:Epoprostenol / Q000235:genetics*; D015316:Genetic Therapy; D006323:Heart Arrest / Q000235:genetics* / Q000517:prevention & control; D006331:Heart Diseases / Q000235:genetics / Q000517:prevention & control; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000096:biosynthesis*; D051379:Mice; D020521:Stroke / Q000235:genetics* / Q000517:prevention & control; D013927:Thrombosis / Q000235:genetics* / Q000517:prevention & control
chemical_list: D003577:Cytochrome P-450 Enzyme System; D011464:Epoprostenol; D051545:Cyclooxygenase 1; D019746:Intramolecular Oxidoreductases; C022461:prostacyclin synthetase
keywords: Cardiac arrest; Prostacyclin; Prostaglandin I(2); Stroke; Transgenic mice