title: Controversies on HDL: should it be a target biomarker in patients with lipid disorders?
abstract: Low-density lipoprotein (LDL) cholesterol lowering with statins have had a profound impact on cardiovascular (CV) event rates and accordingly have become an integral component of strategies designed to reduce CV risk. The finding of a residual clinical risk, despite LDL cholesterol lowering, supports the need to develop additional therapeutic strategies for CV prevention. Numerous lines of evidence suggest that targeting the protective properties of high-density lipoproteins (HDL) may be beneficial. Disappointing results from recent reports of HDL genetics and raising agents and clinical events has fueled considerable debate as to whether attempts to target HDL will be of clinical benefit or futility. This review will reflect on challenges faced in developing new effective HDL targeted therapies.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Nicholls
authors.forename: Jordan
authors.initials: J
authors.lastname: Andrews
authors.affiliation: South Australian Health and Medical Research Institute, PO Box 11060, Adelaide, SA, 5001, Australia. stephen.nicholls@sahmri.com.
authors.forename: MyNgan
authors.initials: M
authors.lastname: Duong
mesh_terms: D016632:Apolipoprotein A-I / Q000096:biosynthesis; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors; D008076:Cholesterol, HDL / Q000008:administration & dosage / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008099:Liver / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009525:Niacin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D016632:Apolipoprotein A-I; D015415:Biomarkers; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009525:Niacin