title: Study of impact of antitubercular therapy on quality of life.
abstract: BACKGROUND
  Many aspects of tuberculosis (TB) and its treatment can compromise patients' quality of life (QOL). Treatment of active TB requires prolonged therapy with multiple drugs that can lead to adverse reactions. There is considerable social stigma associated with TB, leaving the individual feeling shunned and isolated. Hence, it is necessary that for a thorough assessment of patients' health status, overall impact of TB on patient's QOL should be considered.
  
  
  METHODS
  Thirty newly diagnosed smear positive cases of pulmonary TB, of either gender were interviewed using - WHO QOL BREF, which is a 26-item scale designed by WHO. It has four domains viz.: Physical health, psychological health, social relationships, and environment. Interviews were conducted thrice: Before starting treatment, after 2 months, and after 4 months of treatment. Controls ( n = 30) were selected from the general population and interviewed using same questionnaire.
  
  
  RESULTS
  Before treatment, scores in all domains were significantly lower in patients than controls. Worst affected were physical domain followed by psychological. Gradual increase in scores was observed over the course of treatment, indicating positive effect of medical intervention on QOL. Despite improvements, the scores in physical and psychological domain after 4 months of treatment were still significantly lower in patients than in controls.
  
  
  CONCLUSIONS
  Measurement of QOL in TB is essential to have an in-depth understanding of effect of disease on various dimensions of health. This would enable health care professionals to devise relevant interventions such as patient counselling which would be useful in further improving quality of TB control programs.
authors.affiliation: Department of Pharmacology, Government Medical College, Nagpur, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Balgude
authors.forename: Smita
authors.initials: S
authors.lastname: Sontakke
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents