title: SPECT myocardial perfusion in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
abstract: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary small vessel disease. Although the symptoms are exclusively neurological, arteriopathy is generalized. We performed cardiac evaluation using myocardial perfusion single photon emission computed tomography (SPECT), dual-source 128-channel multidetector computed tomography (MDCT) angiogram, echocardiogram, and electrocardiogram (ECG) in a 46-year-old woman with CADASIL. No abnormal findings were observed on MDCT angiogram, echocardiogram, or ECG. However, SPECT demonstrated reversible perfusion defects in the left anterior descending artery territory. We suggest that myocardial perfusion SPECT is a valuable tool to identify risk from cardiovascular accident in CADASIL patients.
authors.affiliation: From the *Department of Nuclear Medicine, †Neurology, ‡Internal Medicine, Cardiology Division, §Physical Medicine and Rehabilitation, and ¶Radiology, Wonkwang University School of Medicine and Institute of Wonkwang Medical Science, Iksan, Republic of Korea.
authors.forename: Soon-Ah
authors.initials: SA
authors.lastname: Park
authors.forename: Kwang Ho
authors.initials: KH
authors.lastname: Cho
authors.forename: Nam-Ho
authors.initials: NH
authors.lastname: Kim
authors.forename: Chung-Yong
authors.initials: CY
authors.lastname: Yang
authors.forename: Seong Hoon
authors.initials: SH
authors.lastname: Park
mesh_terms: D046589:CADASIL / Q000000981:diagnostic imaging*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D015899:Tomography, Emission-Computed, Single-Photon; D014463:Ultrasonography
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; C078700:technetium tc-99m tetrofosmin