title: Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(I) site that is resistant to O2 oxidation.
abstract: Copper coordination to soluble oligomers of the English (AβH(6)R) mutant of the amyloid-β peptide is probed. Cu(II) coordination yields a square planar (N/O)4 coordination environment, while reduction yields an O2 inert linear bis-His Cu(I) centre.
authors.affiliation: Department of Chemistry, University of Nevada, Reno, NV 89557, USA.
authors.forename: Kristy L
authors.initials: KL
authors.lastname: Peck
authors.forename: Heather S
authors.initials: HS
authors.lastname: Clewett
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Schmitt
authors.forename: Jason
authors.initials: J
authors.lastname: Shearer
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000235:genetics; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D056004:Molecular Dynamics Simulation; D009154:Mutation; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010446:Peptide Fragments / Q000737:chemistry* / Q000235:genetics
chemical_list: D016229:Amyloid beta-Peptides; D056831:Coordination Complexes; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D003300:Copper; D010100:Oxygen