title: Extraosseous Ewing sarcoma and peripheral primitive neuroectodermal tumor of the thyroid gland: Case report and review.
abstract: The Ewing family of tumors and peripheral primitive neuroectodermal tumor (pPNET) represent different manifestations of the same entity. Immunohistochemical and cytogenetic studies suggest that these tumors have a common origin. Ewing sarcoma is more common in bone, while pPNET is more common in soft tissues. Extraosseous Ewing sarcoma (EoES) is rare. We present the case of a 48-year-old man who presented with acute obstructive respiratory failure secondary to a large thyroid swelling. The patient was initially diagnosed with giant B-cell non-Hodgkin lymphoma and treated with chemotherapy. However, subsequent immunohistochemical staining of biopsy specimens revealed that the patient actually had EoES/pPNET of the thyroid gland. We performed a nearly complete surgical resection of the tumor plus a total laryngectomy and resection of five tracheal rings. However, the patient died of a cerebral metastasis 1 month later after he had completed one cycle of postoperative chemotherapy.
authors.affiliation: ENT Department, University of Medicine and Pharmacy "Iuliu HaŢieganu," Cluj-Napoca, 400012, V. Babeş Str., No. 8, Cluj-Napoca, Romania. chirila_magda@yahoo.com
authors.forename: Magdalena
authors.initials: M
authors.lastname: Chirila
authors.forename: Mihaela
authors.initials: M
authors.lastname: Muresan
authors.forename: Elisabeta
authors.initials: E
authors.lastname: Ciuleanu
authors.forename: Marcel
authors.initials: M
authors.lastname: Cosgarea
mesh_terms: D001932:Brain Neoplasms / Q000556:secondary*; D017024:Chemotherapy, Adjuvant; D003951:Diagnostic Errors; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology*; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D012512:Sarcoma, Ewing / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D013965:Thyroidectomy