title: Cembranoids from the soft coral Sinularia rigida with antifouling activities.
abstract: Chemical examination of the soft coral Sinularia rigida resulted in the isolation of 12 new cembranoids, namely, sinulariols T-Z5 (1-12), together with a known analogue, 13. Their structures were determined on the basis of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic analyses in association with MS and IR data. Compounds 7 and 13 showed potent antifouling activity for the inhibition against the barnacle Balanus amphitrite and moderate inhibition against Bugula neritina . The primary structure-activity relationship is discussed.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, People's Republic of China.
authors.forename: Daowan
authors.initials: D
authors.lastname: Lai
authors.forename: Zhufeng
authors.initials: Z
authors.lastname: Geng
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Deng
authors.forename: Leen
authors.initials: L
authors.lastname: van Ofwegen
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D057219:Biofouling / Q000517:prevention & control*; D002681:China; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D001468:Thoracica / Q000187:drug effects* / Q000502:physiology
chemical_list: D004224:Diterpenes