title: A randomized, double-blind, placebo- and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata.
abstract: BACKGROUND
  Alopecia areata (AA) is a common autoimmune condition, causing inflammation-induced hair loss. This disease has very limited treatment possibilities, and no treatment is either curative or preventive. Platelet-rich plasma (PRP) has emerged as a new treatment modality in dermatology, and preliminary evidence has suggested that it might have a beneficial role in hair growth.
  
  
  OBJECTIVE
  To evaluate the efficacy and safety of PRP for the treatment of AA in a randomized, double-blind, placebo- and active-controlled, half-head, parallel-group study.
  
  
  METHODS
  Forty-five patients with AA were randomized to receive intralesional injections of PRP, triamcinolone acetonide (TrA) or placebo on one half of their scalp. The other half was not treated. Three treatments were given for each patient, with intervals of 1 month. The endpoints were hair regrowth, hair dystrophy as measured by dermoscopy, burning or itching sensation, and cell proliferation as measured by Ki-67 evaluation. Patients were followed for 1 year.
  
  
  RESULTS
  PRP was found to increase hair regrowth significantly and to decrease hair dystrophy and burning or itching sensation compared with TrA or placebo. Ki-67 levels, which served as markers for cell proliferation, were significantly higher with PRP. No side-effects were noted during treatment.
  
  
  CONCLUSIONS
  This pilot study, which is the first to investigate the effects of PRP on AA, suggests that PRP may serve as a safe and effective treatment option in AA, and calls for more extensive controlled studies with this method.
authors.affiliation: International Hair Research Foundation (IHRF), Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Trink
authors.forename: E
authors.initials: E
authors.lastname: Sorbellini
authors.forename: P
authors.initials: P
authors.lastname: Bezzola
authors.forename: L
authors.initials: L
authors.lastname: Rodella
authors.forename: R
authors.initials: R
authors.lastname: Rezzani
authors.forename: Y
authors.initials: Y
authors.lastname: Ramot
authors.forename: F
authors.initials: F
authors.lastname: Rinaldi
mesh_terms: D000328:Adult; D000506:Alopecia Areata / Q000628:therapy*; D049109:Cell Proliferation; D002908:Chronic Disease; D003879:Dermatologic Agents / Q000008:administration & dosage; D046169:Dermoscopy; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D010865:Pilot Projects; D053657:Platelet-Rich Plasma; D011537:Pruritus / Q000139:chemically induced; D012008:Recurrence; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage
chemical_list: D003879:Dermatologic Agents; D019394:Ki-67 Antigen; D014221:Triamcinolone