title: Association and risk factors between induction of labor and cesarean section.
abstract: OBJECTIVE
  To determine risk factors and to quantify the risk of cesarean section (CS) associated with labor induction.
  
  
  METHODS
  A prospective controlled study of women admitted for labor induction with PGE2 in a single tertiary medical center. Outcome was compared with women who presented with spontaneous onset of delivery.
  
  
  RESULTS
  The induction group were characterized by a higher body mass index (BMI), lower Bishop score and a higher cervical length at presentation compared with controls. Labor induction with PGE2 was associated with increased risk of CS (14.8% versus 4.5%, p = 0.02). This association persists after adjustment for potential confounders including Bishop score at presentation (OR = 2.9, 95% CI 1.03-11.8). The risk of CS was especially high for nulliparous (24.4% versus 5.1%, p = 0.02), overweight (21.2% versus 3.7%, p = 0.047), induction at <40 weeks of gestation (22.2% versus 2.2%, p = 0.004), in Bishop score <4 (18.2% versus 4.5%, p = 0.03), cervical length >25 mm (19.2% versus 4.5%, p = 0.005), or intact membranes (25.0% versus 4.5%, p = 0.02) at presentation.
  
  
  CONCLUSIONS
  Labor induction with PGE2 is associated with increased risk of CS. These data should be taken into consideration when deciding on labor induction, especially in the absence of clear medical indication.
authors.affiliation: Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
authors.forename: Yariv
authors.initials: Y
authors.lastname: Yogev
authors.forename: Liran
authors.initials: L
authors.lastname: Hiersch
authors.forename: Or
authors.initials: O
authors.lastname: Yariv
authors.forename: Yoav
authors.initials: Y
authors.lastname: Peled
authors.forename: Arnon
authors.initials: A
authors.lastname: Wiznitzer
authors.forename: Nir
authors.initials: N
authors.lastname: Melamed
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000502:physiology; D016022:Case-Control Studies; D002585:Cesarean Section / Q000706:statistics & numerical data*; D015232:Dinoprostone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007747:Labor Stage, First / Q000502:physiology; D007748:Labor Stage, Second / Q000502:physiology; D007751:Labor, Induced / Q000009:adverse effects* / Q000706:statistics & numerical data*; D011247:Pregnancy; D012307:Risk Factors; D017211:Treatment Failure
chemical_list: D015232:Dinoprostone