title: The high diversity of arsenolipids in herring fillet (Clupea harengus).
abstract: Arsenolipids represent a relevant step in the biosynthesis of organoarsenicals from inorganic arsenic compounds. Their fate after human consumption is still uncertain. By means of a HPLC-ICP-MS/ESI-Q-TOF-MS method, 16 lipid soluble arsenic compounds, including seven formerly unknown organoarsenicals, have been identified in commercial herring fillet. The structural assignment was done by exact mass and high resolution MS/MS data. This is the first identification of arsenolipids in herring (Clupea harengus). They contribute with (3.6±0.2) mg kg(-1) arsenic to 62.3% of the total arsenic content of (5.7±0.3) mg of arsenic per kg dry mass. Current studies indicate that a metabolization by humans to cancerous dimethylarsinic acid is very likely. The presented results are highly relevant as herring is a very popular food fish species in Europe. Moreover, the screening of different fish species revealed that arsenolipids are more widespread than previously assumed.
authors.affiliation: BAM-Federal Institute for Materials Research and Testing, Department of Analytical Chemistry; Reference Materials, Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Lischka
authors.forename: U
authors.initials: U
authors.lastname: Arroyo-Abad
authors.forename: J
authors.initials: J
authors.lastname: Mattusch
authors.forename: A
authors.initials: A
authors.lastname: Kühn
authors.forename: Ch
authors.initials: Ch
authors.lastname: Piechotta
mesh_terms: D000818:Animals; D001151:Arsenic / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D005399:Fishes; D008055:Lipids / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D008055:Lipids; D001151:Arsenic