title: Childhood central nervous system vasculitis.
abstract: Inflammatory brain diseases in childhood are underrecognized and lead to devastating yet potentially reversible deficits. New-onset neurologic or psychiatric deficits in previously healthy children mandate an evaluation for an underlying inflammatory brain disease. Distinct disease entities, such as central nervous system (CNS) vasculitis, are now being increasingly reported in children. Clinical symptoms, initial laboratory test, and neuroimaging studies help to differentiate between different causes; however, more invasive tests, such as lumbar puncture, conventional angiography, and/or brain biopsy, are usually necessary before the start of treatment. This article focuses on childhood CNS vasculitis.
authors.affiliation: Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Mahendranath
authors.initials: M
authors.lastname: Moharir
authors.forename: Manohar
authors.initials: M
authors.lastname: Shroff
authors.forename: Susanne M
authors.initials: SM
authors.lastname: Benseler
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply; D002533:Cerebral Angiography / Q000379:methods*; D002536:Cerebral Arteries / Q000473:pathology; D002544:Cerebral Infarction / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D002648:Child; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009460:Neurologic Examination; D011379:Prognosis; D013116:Spinal Cord / Q000098:blood supply; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy
chemical_list: D000305:Adrenal Cortex Hormones; D000925:Anticoagulants