title: The association of markers of oxidative-inflammatory status with malnutrition in hemodialysis patients with serum ferritin lower than 500 ng/mL.
abstract: BACKGROUND
  Enhanced inflammatory-oxidative status is well established in chronic kidney disease.
  
  
  OBJECTIVE
  The objective of this study was to evaluate the oxidative- inflammatory status and iron indices in patients undergoing maintenance hemodialysis (HD) with serum ferritin lower than 500 ng/mL, and to correlate them with nutritional status.
  
  
  METHODS
  In a cross-sectional survey 35 HD patients (23 with normal nutritional status, 12 with Protein-Energy-Wasting syndrome, PEW), and healthy volunteers (n = 35) were studied. Serum concentration of iron, ferritin, transferrin saturation, malondialdehyde (MDA), protein carbonyl (PC), high-sensitive serum C -reactive protein (hs-CRP) and blood counts were determined. The nutritional status was determined by anthropometric and biochemical criteria.
  
  
  RESULTS
  HD patients showed low values of hemoglobin and higher values of ferritin, MDA and PC when compared with healthy volunteers. HD subjects with PEW had higher values of PC and hs-PCR as compared to HD patients with normal nutritional status. A multiple logistic regression analysis showed that the independent variables PC (Wald Statistic 4.25, p = 0.039) and hs-CRP (Wald Statistic 4.83, p = 0.028) where related with the patients' nutritional condition.
  
  
  CONCLUSIONS
  In HD patients with serum ferritin below 500 ng/mL was observed one association of the markers of oxidative stress and inflammation with poor nutritional status independently of serum ferritin, gender and age.
authors.affiliation: Faculdade de Ciências da Saúde, UnB.
authors.forename: Simone Gonçalves de
authors.initials: SG
authors.lastname: Almeida
authors.forename: Joel Paulo Russomano
authors.initials: JP
authors.lastname: Veiga
authors.forename: Sandra Fernandes
authors.initials: SF
authors.lastname: Arruda
authors.forename: Cibele Ferreira
authors.initials: CF
authors.lastname: Neves
authors.forename: Egle Machado de Almeida
authors.initials: EM
authors.lastname: Siqueira
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000209:etiology; D008297:Male; D044342:Malnutrition / Q000209:etiology / Q000276:immunology* / Q000378:metabolism*; D008875:Middle Aged; D009752:Nutritional Status; D018384:Oxidative Stress; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000276:immunology / Q000378:metabolism / Q000628:therapy
chemical_list: D015415:Biomarkers; D005293:Ferritins