title: High b-value diffusion tensor imaging of the remote white matter and white matter of obstructive unilateral cerebral arterial regions.
abstract: OBJECTIVE
  To assess diffusion changes in the remote white matter and areas of white matter with cerebral artery obstruction without magnetic resonance imaging (MRI) evidence of brain parenchymal abnormalities using high b-value diffusion tensor imaging (DTI).
  
  
  METHODS
  A total of 34 patients with severe unilateral stenosis (≥75%) or occlusion of the middle cerebral artery (MCA) without abnormal brain parenchymal signals at MRI underwent DTI with a b value of 2200 s/mm(2) at 3 T. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial diffusivity (eigenvalue λ₁) and radial diffusivity (eigenvalue λ₂₃) were measured at the bilateral corona radiata, anterior and posterior limbs of the internal capsule, cerebral peduncle, and pons.
  
  
  RESULTS
  The mean FA was significantly lower at the ipsilateral corona radiata and anterior and posterior limbs of the internal capsule than at the contralateral corona radiata and anterior and posterior limbs of the internal capsule (p < 0.05). The mean ADC, λ₁ and λ₂₃ were significantly higher at the ipsilateral corona radiata than at the contralateral corona radiata (p < 0.01). The mean λ₂₃ were significantly higher at the ipsilateral anterior and posterior limb of the internal capsule than at the contralateral anterior and posterior limb of the internal capsule (p < 0.05). The mean ADC, λ₁ and λ₂ ₃were not significantly different between the ipsilateral cerebral peduncle and pons.
  
  
  CONCLUSIONS
  High b-value DTI could sensitively reveal diffusion changes in white matter in regions of cerebral artery obstruction without abnormal anisotropy and diffusivity of the remote white matter of patients with severe MCA stenosis or occlusion without MRI evidence of brain parenchymal abnormalities.
authors.affiliation: Department of Radiology, Qi Lu Hospital of Shandong University, Jinan, China.
authors.forename: X
authors.initials: X
authors.lastname: Meng
authors.forename: C
authors.initials: C
authors.lastname: Jun
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Hou
authors.forename: Q
authors.initials: Q
authors.lastname: Zeng
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Ma
mesh_terms: D000328:Adult; D000368:Aged; D016880:Anisotropy; D001157:Arterial Occlusive Diseases / Q000473:pathology*; D002536:Cerebral Arteries / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*