title: High-sensitive cardiac troponin T.
abstract: Cardiac troponin is the preferred biomarker for the diagnosis of acute myocardial infarction (AMI). The recent development of a high-sensitive cardiac troponin T (hs-cTnT) assay permits detection of very low levels of cTnT. Using the hs-cTnT assay improves the overall diagnostic accuracy in patients with suspected AMI, while a negative result also has a high negative predictive value. The gain in sensitivity may be particularly important in patients with a short duration from symptom onset to admission. Measurement of cardiac troponin T with the hs-cTnT assay may provide strong prognostic information in patients with acute coronary syndromes, stable coronary artery disease, heart failure and even in the general population; however, increased sensitivity comes at a cost of decreased specificity. Serial testing, as well as clinical context and co-existing diseases, are likely to become increasingly important for the interpretation of hs-cTnT assay results.
authors.affiliation: Department of Geriatric Cardiology, Navy General Hospital, No.6, Fucheng Road, Beijing 100048, China.
authors.forename: Ru-Yi
authors.initials: RY
authors.lastname: Xu
authors.forename: Xiao-Fa
authors.initials: XF
authors.lastname: Zhu
authors.forename: Ye
authors.initials: Y
authors.lastname: Yang
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
keywords: Acute myocardial infarction; Risk stratification; Troponin T