title: [Apoptosis-modulating effects of heat shock proteins: the influence of Hsp27 chaperone on TBA Bcl-2 family proteins in Jurkat cell line].
abstract: The in vitro phosphorylated and non-phosphorylated Hsp27 forms concentrations and Bcl-2 proteins affected by Hsp27 inhibition were studied in Jurkat-line tumor cells and healthy donor mononuclear lymphocytes by Western blotting technique. The Hsp27 inhibition causes the increase of intracellular Bax protein concentration and the decrease of Bcl-2 level leading to an increase of apoptotic changes in Jurkat line cells.
authors.forename: N V
authors.initials: NV
authors.lastname: Riazantseva
authors.forename: E V
authors.initials: EV
authors.lastname: Kaĭgorodova
authors.forename: A N
authors.initials: AN
authors.lastname: Maroshkina
authors.forename: M V
authors.initials: MV
authors.lastname: Belkina
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskiĭ
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D015153:Blotting, Western; D055551:HSP27 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D019169:Jurkat Cells / Q000187:drug effects / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000187:drug effects / Q000378:metabolism*; D051028:bcl-2-Associated X Protein / Q000187:drug effects / Q000378:metabolism*; D051025:bcl-Associated Death Protein / Q000187:drug effects / Q000378:metabolism*
chemical_list: D051017:Apoptosis Regulatory Proteins; C494819:BAD protein, human; C494826:BAX protein, human; C481505:BCL2L15 protein, human; D055551:HSP27 Heat-Shock Proteins; D018832:Molecular Chaperones; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D051025:bcl-Associated Death Protein