title: Methylation of cytochrome p450 2E1 promoter induced by low dosage of isoniazid.
abstract: OBJECTIVE
  To find new diagnostic markers to monitor isoniazid-induced liver injury.
  
  
  METHODS
  SD rats were treated with low dosage of isoniazid and the light microscopic findings of livers were collected. The methylation status of cytochrome p450 2E1 promoter was determined.
  
  
  RESULTS
  Cell edema and spotty necrosis on liver cells appeared in the experimental group and promoter methylation of cytochrome p450 2E1 was detected.
  
  
  CONCLUSIONS
  Low-dosage isoniazid can induce liver injury.
authors.affiliation: Communication University of China, No. 1 Dingfuzhuang East Street, Chaoyang District, Beijing 100024, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Shen
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.forename: Shufeng
authors.initials: S
authors.lastname: Sun
authors.forename: Fumin
authors.initials: F
authors.lastname: Feng
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000633:toxicity*; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics* / Q000378:metabolism; D019175:DNA Methylation; D007538:Isoniazid / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D011401:Promoter Regions, Genetic; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000995:Antitubercular Agents; D019392:Cytochrome P-450 CYP2E1; D007538:Isoniazid