title: Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.
abstract: Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.
authors.affiliation: Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA.
authors.forename: Gerlinde
authors.initials: G
authors.lastname: Obermoser
authors.forename: Scott
authors.initials: S
authors.lastname: Presnell
authors.forename: Kelly
authors.initials: K
authors.lastname: Domico
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Esperanza
authors.initials: E
authors.lastname: Anguiano
authors.forename: Luann
authors.initials: L
authors.lastname: Thompson-Snipes
authors.forename: Rajaram
authors.initials: R
authors.lastname: Ranganathan
authors.forename: Brad
authors.initials: B
authors.lastname: Zeitner
authors.forename: Anna
authors.initials: A
authors.lastname: Bjork
authors.forename: David
authors.initials: D
authors.lastname: Anderson
authors.forename: Cate
authors.initials: C
authors.lastname: Speake
authors.forename: Emily
authors.initials: E
authors.lastname: Ruchaud
authors.forename: Jason
authors.initials: J
authors.lastname: Skinner
authors.forename: Laia
authors.initials: L
authors.lastname: Alsina
authors.forename: Mamta
authors.initials: M
authors.lastname: Sharma
authors.forename: Helene
authors.initials: H
authors.lastname: Dutartre
authors.forename: Alma
authors.initials: A
authors.lastname: Cepika
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Israelsson
authors.forename: Phuong
authors.initials: P
authors.lastname: Nguyen
authors.forename: Quynh-Anh
authors.initials: QA
authors.lastname: Nguyen
authors.forename: A Carson
authors.initials: AC
authors.lastname: Harrod
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Zurawski
authors.forename: Virginia
authors.initials: V
authors.lastname: Pascual
authors.forename: Hideki
authors.initials: H
authors.lastname: Ueno
authors.forename: Gerald T
authors.initials: GT
authors.lastname: Nepom
authors.forename: Charlie
authors.initials: C
authors.lastname: Quinn
authors.forename: Derek
authors.initials: D
authors.lastname: Blankenship
authors.forename: Karolina
authors.initials: K
authors.lastname: Palucka
authors.forename: Jacques
authors.initials: J
authors.lastname: Banchereau
authors.forename: Damien
authors.initials: D
authors.lastname: Chaussabel
mesh_terms: D056704:Adaptive Immunity; D000917:Antibody Formation; D049109:Cell Proliferation; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000378:metabolism; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology*; D007372:Interferons / Q000235:genetics / Q000378:metabolism*; D022423:Myeloid Cells / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D009975:Orthomyxoviridae / Q000276:immunology*; D011008:Pneumococcal Infections / Q000276:immunology*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D012984:Software; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014611:Vaccination
chemical_list: D018836:Inflammation Mediators; D007252:Influenza Vaccines; D022242:Pneumococcal Vaccines; D007372:Interferons