title: Caffeoyl triterpenes from pear (Pyrus pyrifolia Nakai) fruit peels and their antioxidative activities against oxidation of rat blood plasma.
abstract: Six triterpenes, including three caffeoyl triterpenes, were purified and isolated from pear fruit ( Pyrus pyrifolia Nakai cv. Chuwhangbae) peel extracts using various column chromatography techniques with a guided 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay. The isolated compounds were identified as betulinic aldehyde (1), lupeol (2), betulinic acid (3), 3-O-cis-caffeoylbetulinic acid (4), 3-O-trans-caffeoylbetulinic acid (5), and 3-O-trans-caffeoyloleanolic acid (6) on the basis of nuclear magnetic resonance spectroscopy and electrospray ionization mass spectrometry. Four compounds (1, 4-6) were identified from Asian pear fruit for the first time. In addition, compounds 4-6, containing a caffeic acid moiety, showed higher DPPH radical-scavenging and suppression effects against copper ion-induced oxidation of rat blood plasma than other compounds without a caffeic acid moiety.
authors.affiliation: Department of Food Science & Technology and Functional Food Research Center, Chonnam National University, Gwangju 500-757, Korea.
authors.forename: Jeong-Yong
authors.initials: JY
authors.lastname: Cho
authors.forename: Chan Mi
authors.initials: CM
authors.lastname: Kim
authors.forename: Hyoung Jae
authors.initials: HJ
authors.lastname: Lee
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Lee
authors.forename: Jeong-An
authors.initials: JA
authors.lastname: Cho
authors.forename: Wol-Soo
authors.initials: WS
authors.lastname: Kim
authors.forename: Keun-Hyung
authors.initials: KH
authors.lastname: Park
authors.forename: Jae-Hak
authors.initials: JH
authors.lastname: Moon
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D002109:Caffeic Acids / Q000494:pharmacology; D002788:Cholesterol Esters / Q000037:antagonists & inhibitors / Q000378:metabolism; D005638:Fruit / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D010084:Oxidation-Reduction; D053978:Pentacyclic Triterpenes; D010851:Picrates / Q000494:pharmacology; D031989:Pyrus / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000494:pharmacology*; D000094062:Betulinic Acid
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D002109:Caffeic Acids; D002788:Cholesterol Esters; D053978:Pentacyclic Triterpenes; D010851:Picrates; D014315:Triterpenes; C081459:cholesteryl ester hydroperoxide; C002503:betulin; C004931:1,1-diphenyl-2-picrylhydrazyl; C040048:caffeic acid; D000094062:Betulinic Acid