title: Primary angiosarcoma of the breast: a case report.
abstract: Primary angiosarcoma of the breast is extremely rare. Radiologic findings are often non specific and may appear completely normal in one-third of cases with primary angiosarcoma. The prognosis is usually poor because of the high rates of local recurrence and early development of metastasis. Surgical removal followed by adjuvant chemotherapy seems improve the prognosis. We report a case of a 33- year-old woman with a highly vascular mass in her right breast which is suggestive of malignancy at radiology. Initial core needle biopsy showed a benign hemangioma. The patient underwent a mastectomy. The tumor histology showed papillary formations and vascular structures lined by atypical cells with hyperchromatic nucleus and eosinophilic cytoplasm with solid areas. The tumor cells expressed CD34 and CD31 but were negative for cytokeratin. The diagnosis of angiosarcoma grade III was made. The patient is now receiving chemotherapy. She is still alive.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1530481200889780.
authors.affiliation: Department of Pathology, HASSAN II University Hospital, Fez 30000, Morocco. bennaniamal@gmail.com
authors.forename: Amal
authors.initials: A
authors.lastname: Bennani
authors.forename: Layla
authors.initials: L
authors.lastname: Chbani
authors.forename: Meryem
authors.initials: M
authors.lastname: Lamchahab
authors.forename: Mouhcine
authors.initials: M
authors.lastname: Wahbi
authors.forename: Fatimazzahra Fdili
authors.initials: FF
authors.lastname: Alaoui
authors.forename: Ikram
authors.initials: I
authors.lastname: Badioui
authors.forename: Moulay Abdelilah
authors.initials: MA
authors.lastname: Melhouf
authors.forename: Affaf
authors.initials: A
authors.lastname: Amarti
mesh_terms: D000328:Adult; D001706:Biopsy / Q000379:methods; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007633:Keratins / Q000378:metabolism; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis
chemical_list: D007633:Keratins