title: Antibody-functionalized magnetic polymersomes: in vivo targeting and imaging of bone metastases using high resolution MRI.
abstract: Multifunctional polymersomes loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody-labeled polymersomes at the tumor site.
authors.affiliation: Centre de Résonance Magnétique, des Systèmes Biologiques, UMR 5536, Université Bordeaux Segalen, CNRS, France.
authors.forename: Line
authors.initials: L
authors.lastname: Pourtau
authors.forename: Hugo
authors.initials: H
authors.lastname: Oliveira
authors.forename: Julie
authors.initials: J
authors.lastname: Thevenot
authors.forename: Yali
authors.initials: Y
authors.lastname: Wan
authors.forename: Alain R
authors.initials: AR
authors.lastname: Brisson
authors.forename: Olivier
authors.initials: O
authors.lastname: Sandre
authors.forename: Sylvain
authors.initials: S
authors.lastname: Miraux
authors.forename: Eric
authors.initials: E
authors.lastname: Thiaudiere
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lecommandoux
mesh_terms: D000818:Animals; D000906:Antibodies / Q000378:metabolism*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D045744:Cell Line, Tumor; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D060328:Magnetic Phenomena; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D014018:Tissue Distribution
chemical_list: D000906:Antibodies; D005290:Ferric Compounds; D011108:Polymers; C000499:ferric oxide
keywords: bone tumor; magnetic resonance imaging; polymersome; targeting