title: Long-term success of mitomycin-augmented trabeculectomy for glaucoma after vitreoretinal surgery with silicone oil insertion: a prospective case series.
abstract: OBJECTIVE
  To evaluate the long-term success of trabeculectomy with mitomycin C for glaucoma after vitreoretinal surgery with silicone oil insertion.
  
  
  METHODS
  Prospective evaluation of patients who underwent trabeculectomy with mitomycin C (superior or inferior site) for glaucoma after vitreoretinal surgery. Parameters examined included intraocular pressure (IOP), visual acuity, and glaucomatous neuropathy status, preoperatively and at multiple follow-up visits postoperatively till 12 months. Success, both absolute (IOP <21 mmHg) and qualified (IOP <21 mmHg with the use of medications and/or needling), was determined at each follow-up visit.
  
  
  RESULTS
  Nineteen patients with mean age of 29 ± 16 years had a mean untreated baseline IOP of 42.5 ± 10.66 mmHg, which reduced to 23.82 ± 7.58 at 1 year (P = 0.008). Preoperative decimal visual acuity was 0.12 ± 0.21, which worsened to 0.07 ± 0.08 at the final follow-up (P = 0.81). Total success rate was 36.9% at the end of 1 year, whereas absolute success rate was only 15.8%. Duration between vitreoretinal surgery and silicone oil removal, preoperative IOP, or site of surgery did not determine success rate.
  
  
  CONCLUSIONS
  Twelve-month success rate for trabeculectomy with mitomycin C in glaucoma after vitreoretinal surgery with silicone oil insertion is lower than reported for most refractory glaucomas.
authors.affiliation: Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Digvijay
authors.initials: D
authors.lastname: Singh
authors.forename: Anuradha
authors.initials: A
authors.lastname: Chandra
authors.forename: Ramanjit
authors.initials: R
authors.lastname: Sihota
authors.forename: Sandip
authors.initials: S
authors.lastname: Kumar
authors.forename: Viney
authors.initials: V
authors.lastname: Gupta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000477:Alkylating Agents / Q000008:administration & dosage*; D002648:Child; D058450:Endotamponade; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D011446:Prospective Studies; D012827:Silicone Oils; D014065:Tonometry, Ocular; D014130:Trabeculectomy / Q000379:methods*; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D057586:Vitreoretinal Surgery / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000477:Alkylating Agents; D012827:Silicone Oils; D016685:Mitomycin