title: DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state.
abstract: Caenorhabditis elegans DJR-1.2, a homolog of human DJ-1, has recently been demonstrated to be a novel glyoxalase and protects worms against glyoxals. Here, we report that expression of DJR-1.2 is substantially increased during starvation as well as in the dauer stage. The induction of DJR-1.2 led to increased glyoxalase activity in the dauer state, thereby increasing protection against glyoxals. The induction is regulated by DAF-16, a transcriptional regulator implicated in oxidative stress and normal lifespan.
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon 305-701, Republic of Korea. daydream88@kaist.ac.kr
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Chayeon
authors.initials: C
authors.lastname: Kim
authors.forename: Jeongho
authors.initials: J
authors.lastname: Kim
authors.forename: Chankyu
authors.initials: C
authors.lastname: Park
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics / Q000378:metabolism; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D004789:Enzyme Activation; D005508:Food Deprivation; D051858:Forkhead Transcription Factors; D015971:Gene Expression Regulation, Enzymologic; D006037:Glyoxal / Q000494:pharmacology; D006066:Gonads / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress; D016019:Survival Analysis; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; D014157:Transcription Factors; C108831:daf-16 protein, C elegans; D006037:Glyoxal; D000445:Aldehyde Oxidoreductases; C577307:DJR-1.2 protein, C elegans