title: Effects of vaccine program against pandemic influenza A(H1N1) virus, United States, 2009-2010.
abstract: In April 2009, the United States began a response to the emergence of a pandemic influenza virus strain: A(H1N1)pdm09. Vaccination began in October 2009. By using US surveillance data (April 12, 2009-April 10, 2010) and vaccine coverage estimates (October 3, 2009-April 18, 2010), we estimated that the A(H1N1)pdm09 virus vaccination program prevented 700,000-1,500,000 clinical cases, 4,000-10,000 hospitalizations, and 200-500 deaths. We found that the national health effects were greatly influenced by the timing of vaccine administration and the effectiveness of the vaccine. We estimated that recommendations for priority vaccination of targeted priority groups were not inferior to other vaccination prioritization strategies. These results emphasize the need for relevant surveillance data to facilitate a rapid evaluation of vaccine recommendations and effects.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
authors.forename: Rebekah H
authors.initials: RH
authors.lastname: Borse
authors.forename: Sundar S
authors.initials: SS
authors.lastname: Shrestha
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Fiore
authors.forename: Charisma Y
authors.initials: CY
authors.lastname: Atkins
authors.forename: James A
authors.initials: JA
authors.lastname: Singleton
authors.forename: Carolyn
authors.initials: C
authors.lastname: Furlow
authors.forename: Martin I
authors.initials: MI
authors.lastname: Meltzer
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D062665:Epidemiological Monitoring; D006760:Hospitalization; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control*; D032541:Mass Vaccination; D008875:Middle Aged; D015233:Models, Statistical; D058873:Pandemics; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D007252:Influenza Vaccines
keywords: A(H1N1)pdm09; H1N1; Influenza; model; pandemic; vaccination; vaccine; viruses