title: [Immune functions of patients following lobectomy for lung cancers: a comparative study between video-assisted thoracoscopic surgery and posterolateral thoracotomy].
abstract: OBJECTIVE
  To compare acute inflammatory responses and immunosuppression to lobectomy in lung cancer patients with video-assisted thoracoscopic surgery (VATS) and posterolateral thoracotomy (PLT).
  
  
  METHODS
  A total of 103 patients who underwent either a VATS (n = 51) or a PLT (n = 52) lobectomy for early non-small cell lung cancers (NSCLC, stage I ) were recruited for this study. Blood samples of the participants were taken preoperatively and at 24 h and 72 h post-operatively for analyses of C-reactive protein (CRP), interleukin (IL)-6, IL-2 receptors (IL-2R), and serum amyloid A (SAA). Blood samples taken pre-operatively and at 2 d and 7 d post operations were also analyzed for total lymphocytes, NK cells, CD4+ T, and CD8+ T.
  
  
  RESULTS
  Patients in the VATS group lost significantly less blood than those in the PLT group (P = 0.001). Patients in the PLT group had significantly higher serum SAA than those in the VATS group (P = 0. 006). Significant reduction of CD8+ T was found in the patients with PLT after operations (P < 0.01). Patients in the PLT group had significantly lower at CD8+ T 7 d post operations than those in the VATS group (P = 0.015).
  
  
  CONCLUSIONS
  VATS pulmonary lobectomy is associated with reduced acute inflammatory responses and immunosuppression compared with the PLT approach.
authors.affiliation: Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Pu
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Mei
authors.forename: Yun-Ke
authors.initials: YK
authors.lastname: Zhu
authors.forename: Guo-Wei
authors.initials: GW
authors.lastname: Che
authors.forename: Yi-Dan
authors.initials: YD
authors.lastname: Lin
authors.forename: Zhu
authors.initials: Z
authors.lastname: Wu
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
authors.forename: Ying-Li
authors.initials: YL
authors.lastname: Kou
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Yang
authors.forename: Lun-Xu
authors.initials: LX
authors.lastname: Liu
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology* / Q000601:surgery; D011013:Pneumonectomy; D000685:Serum Amyloid A Protein / Q000378:metabolism; D020775:Thoracic Surgery, Video-Assisted; D013908:Thoracotomy
chemical_list: D000685:Serum Amyloid A Protein