title: Repressing the repressor: a lincRNA as a MicroRNA sponge in embryonic stem cell self-renewal.
abstract: Large intergenic noncoding (linc) RNAs constitute a new dimension of posttranscriptional gene regulation. In this issue of Developmental Cell, Wang et al. (2013) find that linc-RoR maintains human embryonic stem cell self-renewal by functioning as a sponge to trap miR-145, thus regulating core pluripotency factors Oct4, Nanog, and Sox2.
authors.affiliation: Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06509, USA.
authors.forename: Ee-chun
authors.initials: EC
authors.lastname: Cheng
authors.forename: Haifan
authors.initials: H
authors.lastname: Lin