title: Enantioselective thiourea-catalyzed intramolecular cope-type hydroamination.
abstract: Catalysis of Cope-type rearrangements of bis-homoallylic hydroxylamines is demonstrated using chiral thiourea derivatives. This formal intramolecular hydroamination reaction provides access to highly enantioenriched α-substituted pyrrolidine products and represents a complementary approach to metal-catalyzed methods.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.
authors.forename: Adam R
authors.initials: AR
authors.lastname: Brown
authors.forename: Christopher
authors.initials: C
authors.lastname: Uyeda
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Brotherton
authors.forename: Eric N
authors.initials: EN
authors.lastname: Jacobsen
mesh_terms: D000586:Amination; D002384:Catalysis; D019811:Hydroxylamine / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011789:Quantum Theory; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D019811:Hydroxylamine; D013890:Thiourea