title: Impact of thearubigins on the estimation of total dietary flavonoids in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
abstract: Thearubigins (TR) are polymeric flavanol-derived compounds formed during the fermentation of tea leaves. Comprising ∼70% of total polyphenols in black tea, TR may contribute majorly to its beneficial effects on health. To date, there is no appropriate food composition data on TR, although several studies have used data from the US Department of Agriculture (USDA) database to estimate TR intakes. We aimed to estimate dietary TR in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort and assess the impact of including TR or not in the calculation of the total dietary flavonoid intake. Dietary data were collected using a single standardized 24-h dietary recall interviewer-administered to 36 037 subjects aged 35-74 years. TR intakes were calculated using the USDA database. TR intakes ranged from 0.9 mg/day in men from Navarra and San Sebastian in Spain to 532.5 mg/day in men from UK general population. TR contributed <5% to the total flavonoid intake in Greece, Spain and Italy, whereas in the UK general population, TR comprised 48% of the total flavonoids. High heterogeneity in TR intake across the EPIC countries was observed. This study shows that total flavonoid intake may be greatly influenced by TR, particularly in high black tea-consuming countries. Further research on identification and quantification of TR is needed to get more accurate dietary TR estimations.
authors.affiliation: Catalan Institute of Oncology, Barcelona, Spain. rzamora@iconcologia.net
authors.forename: R
authors.initials: R
authors.lastname: Zamora-Ros
authors.forename: V
authors.initials: V
authors.lastname: Knaze
authors.forename: I
authors.initials: I
authors.lastname: Romieu
authors.forename: A
authors.initials: A
authors.lastname: Scalbert
authors.forename: N
authors.initials: N
authors.lastname: Slimani
authors.forename: F
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: M
authors.initials: M
authors.lastname: Touillaud
authors.forename: F
authors.initials: F
authors.lastname: Perquier
authors.forename: G
authors.initials: G
authors.lastname: Skeie
authors.forename: D
authors.initials: D
authors.lastname: Engeset
authors.forename: E
authors.initials: E
authors.lastname: Weiderpass
authors.forename: I
authors.initials: I
authors.lastname: Johansson
authors.forename: R
authors.initials: R
authors.lastname: Landberg
authors.forename: H B
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: S
authors.initials: S
authors.lastname: Sieri
authors.forename: G
authors.initials: G
authors.lastname: Masala
authors.forename: P H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: V
authors.initials: V
authors.lastname: Grote
authors.forename: J M
authors.initials: JM
authors.lastname: Huerta
authors.forename: A
authors.initials: A
authors.lastname: Barricarte
authors.forename: P
authors.initials: P
authors.lastname: Amiano
authors.forename: F L
authors.initials: FL
authors.lastname: Crowe
authors.forename: E
authors.initials: E
authors.lastname: Molina-Montes
authors.forename: K-T
authors.initials: KT
authors.lastname: Khaw
authors.forename: M V
authors.initials: MV
authors.lastname: Argüelles
authors.forename: A
authors.initials: A
authors.lastname: Tjønneland
authors.forename: J
authors.initials: J
authors.lastname: Halkjær
authors.forename: M S
authors.initials: MS
authors.lastname: de Magistris
authors.forename: F
authors.initials: F
authors.lastname: Ricceri
authors.forename: R
authors.initials: R
authors.lastname: Tumino
authors.forename: E
authors.initials: E
authors.lastname: Wirfält
authors.forename: U
authors.initials: U
authors.lastname: Ericson
authors.forename: K
authors.initials: K
authors.lastname: Overvad
authors.forename: A
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: V
authors.initials: V
authors.lastname: Dilis
authors.forename: P
authors.initials: P
authors.lastname: Vidalis
authors.forename: H
authors.initials: H
authors.lastname: Boeing
authors.forename: J
authors.initials: J
authors.lastname: Förster
authors.forename: E
authors.initials: E
authors.lastname: Riboli
authors.forename: C A
authors.initials: CA
authors.lastname: González
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004032:Diet; D005060:Europe / Q000453:epidemiology; D005419:Flavonoids / Q000032:analysis*; D006801:Humans; D008019:Life Style; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D009369:Neoplasms / Q000517:prevention & control; D009752:Nutritional Status; D059808:Polyphenols / Q000008:administration & dosage*; D011446:Prospective Studies; D013662:Tea / Q000737:chemistry; D044465:White People
chemical_list: D005419:Flavonoids; D059808:Polyphenols; D013662:Tea; C086701:thearubigin; D002392:Catechin