title: Mediation of smoking-associated postoperative mortality by perioperative complications in veterans undergoing elective surgery: data from Veterans Affairs Surgical Quality Improvement Program (VASQIP)--a cohort study.
abstract: OBJECTIVE
  To assess the mediation of smoking-associated postoperative mortality by postoperative complications.
  
  
  METHODS
  Observational cohort study.
  
  
  METHODS
  Using data from the Veterans Affairs (VA) Surgical Quality Improvement Programme, a quality assurance programme for major surgical procedures in the VA healthcare system, we assessed the association of current smoking at the time of the surgery with 6-month and 1-year mortality.
  
  
  METHODS
  Using mediation analyses, we calculated the relative contribution of each smoking-associated complication to smoking-associated postoperative mortality, both unadjusted and adjusted for age, race/ethnicity, work relative value unit of the operation, surgeon specialty, American Society of Anesthesiologists class and year of surgery. Smoking-associated complications included surgical site infection (SSI), cardiovascular complications (myocardial infarction, cardiac arrest and/or stroke) and pulmonary complications (pneumonia, failure to wean and/or reintubation).
  
  
  RESULTS
  There were 186 632 never smokers and 135 741 current smokers. The association of smoking and mortality was mediated by smoking-related complications with varying effects. In unadjusted analyses, the proportions of mediation of smoking to 6-month mortality explained by the complications were as follows: SSIs 22%, cardiovascular complications 12% and pulmonary complications 89%. In adjusted analyses, the per cents mediated by each complication were as follows: SSIs 2%, cardiovascular complications 4% and pulmonary complications 22%. In adjusted analyses for 1-year mortality, respective per cents mediated were 2%, 3% and 16%.
  
  
  CONCLUSIONS
  Pulmonary complications, followed by cardiovascular complications and SSIs were mediators of smoking-associated 6-month and 1-year mortality. Interventions targeting smoking cessation and prevention and early treatment of pulmonary complications has the likelihood of reducing postoperative mortality after elective surgery.
authors.affiliation: Medicine Service, Birmingham VA Medical Center and Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: Jasvinder A
authors.initials: JA
authors.lastname: Singh
authors.forename: Mary
authors.initials: M
authors.lastname: Hawn
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Campagna
authors.forename: William G
authors.initials: WG
authors.lastname: Henderson
authors.forename: Joshua
authors.initials: J
authors.lastname: Richman
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Houston