title: The Correlation between High-Sensitivity C-Reactive Protein, Matrix Metallopeptidase 9, and Traditional Chinese Medicine Syndrome in Patients with Hypertension.
abstract: Hypertension is a common disease affecting millions of people throughout the world. Currently, there is a growing interest in the traditional Chinese medicine (TCM) for patients with hypertension mainly due to the personalized therapy of TCM in many countries. Clinical treatment of patients relies on the successful differentiation of a specific TCM syndrome for hypertension. However, it is difficult to understand that TCM syndrome classifications depend on the clinical experience of a TCM practitioner. Therefore, discovering an objective biomarker associated with TCM syndrome may be beneficial for TCM syndrome classifications. This paper focused on high sensitivity C-reactive protein (HCRP), matrix metallopeptidase 9 (MMP9), and TCM syndrome, and aimed to investigate the relationships between TCM syndrome and the two inflammatory biomarkers in patients with essential hypertension. The result showed that both HCRP and MMP9 are positively correlated with syndrome of wind and phlegm turbidity. Detection of the serum levels of HCRP and MMP9 is beneficial for TCM syndrome classification and prediction of cardiovascular and cerebrovascular risk events in hypertensive patients.
authors.affiliation: Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China.
authors.forename: Aiming
authors.initials: A
authors.lastname: Wu
authors.forename: Dongmei
authors.initials: D
authors.lastname: Zhang
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Gao
authors.forename: Lixia
authors.initials: L
authors.lastname: Lou
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhu
authors.forename: Limin
authors.initials: L
authors.lastname: Chai
authors.forename: Xiying
authors.initials: X
authors.lastname: Lv
authors.forename: Yikun
authors.initials: Y
authors.lastname: Sun
authors.forename: Lingqun
authors.initials: L
authors.lastname: Zhu
authors.forename: Shuoren
authors.initials: S
authors.lastname: Wang