title: Experimental assessment of the environmental fate and effects of triazoles and benzotriazole.
abstract: The environmental fate and effects of triazoles and benzotriazoles are of concern within the context of chemical regulation. As part of an intelligent testing strategy, experimental tests were performed on endpoints that are relevant for risk assessment. The experimental tests included the assessment of ecotoxicity to an alga, a daphnid and zebrafish embryos, and the assessment of ready biodegradability. Triazole and benzotriazole compounds were selected for testing, based on existing toxicity data for vertebrate and invertebrate species, as well as on the principal component analysis of molecular descriptors aimed at selecting the minimum number of test compounds in order to maximise the chemical domain spanned for both compound classes. The experimental results show that variation in the toxicities of triazoles and benzotriazole across species was relatively minor; in general, the largest factor was approximately 20. The study conducted indicated that triazoles are not readily biodegradable.
authors.affiliation: Public Health Institute Maribor, Maribor, Slovenia. mojca.durjava@zzv-mb.si
authors.forename: Mojca Kos
authors.initials: MK
authors.lastname: Durjava
authors.forename: Boris
authors.initials: B
authors.lastname: Kolar
authors.forename: Lovro
authors.initials: L
authors.lastname: Arnus
authors.forename: Ester
authors.initials: E
authors.lastname: Papa
authors.forename: Simona
authors.initials: S
authors.lastname: Kovarich
authors.forename: Ullrika
authors.initials: U
authors.lastname: Sahlin
authors.forename: Willie
authors.initials: W
authors.lastname: Peijnenburg
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D003621:Daphnia; D007928:Lethal Dose 50; D058086:Microalgae; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015027:Zebrafish
chemical_list: D014230:Triazoles; D014874:Water Pollutants, Chemical; C012771:benzotriazole