title: Polymorphisms in DNA repair pathway genes, body mass index, and risk of non-Hodgkin lymphoma.
abstract: We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk.
authors.affiliation: Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; Yale University School of Public Health, New Haven, Connecticut.
authors.forename: Yingtai
authors.initials: Y
authors.lastname: Chen
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
authors.forename: Christopher
authors.initials: C
authors.lastname: Kim
authors.forename: Qin
authors.initials: Q
authors.lastname: Qin
authors.forename: Francine
authors.initials: F
authors.lastname: Foss
authors.forename: Xuezhong
authors.initials: X
authors.lastname: Chen
authors.forename: Theodore
authors.initials: T
authors.lastname: Holford
authors.forename: Brian
authors.initials: B
authors.lastname: Leaderer
authors.forename: Peter
authors.initials: P
authors.lastname: Boyle
authors.forename: Chengfeng
authors.initials: C
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Dai
authors.forename: Zhenjiang
authors.initials: Z
authors.lastname: Liu
authors.forename: Shuangge
authors.initials: S
authors.lastname: Ma
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D016022:Case-Control Studies; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics; D005090:Exodeoxyribonucleases / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D011110:Polymorphism, Genetic; D053484:RecQ Helicases / Q000235:genetics*; D012307:Risk Factors; D044767:Ubiquitin-Protein Ligases / Q000235:genetics; D000071657:Werner Syndrome Helicase; D000076105:X-ray Repair Cross Complementing Protein 1; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; C111164:BRAP protein, human; D044767:Ubiquitin-Protein Ligases; D005090:Exodeoxyribonucleases; D053484:RecQ Helicases; C098785:WRN protein, human; D000071657:Werner Syndrome Helicase; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human