title: Determination of N-nitrosodiethanolamine in cosmetic products by headspace solid phase microextraction using a novel aluminum hydroxide grafted fused silica fiber followed by gas chromatography-mass spectrometry analysis.
abstract: A method based on headspace solid phase microextraction with a new fiber, coupled with gas chromatography-mass spectrometry was developed for the determination of NDELA in cosmetic samples. The fiber provides Lewis acid-base interaction between its surface and analyte functional groups. The fiber was prepared by grafting aluminum tri-tert-butoxide on the surface of a fused silica. The optimization of SPME conditions showed that NDELA can be most effectively extracted at 70°C, in 15 min, with a sample volume of 0.5 (Vs/Vt), stirring rate of 150 rpm, desorption time of 5 min, desorption temperature of 260°C and at 12.5% (w/w) concentration of NaCl. Under the optimized conditions, LOD of 1 μg Kg(-1) and a calibration curve with correlation coefficients greater than 0.9897 and a linearity range from 6 to 10000 μg Kg(-1) were obtained. The intra-day and inter-day precision and accuracy were evaluated at four concentration levels. All of the values for accuracy and precision were lower than the acceptable limit of 15%. The fiber to fiber repeatability was 8.7%. The method was applied for the analysis of real samples including hair shampoo, body shampoo, dishwashing liquid and hand washing liquid. Relative recoveries were achieved in the range of 95-99%.
authors.affiliation: Department of Chemistry, Faculty of Sciences, Shahid Beheshti University G. C., Tehran 1983963113, Islamic Republic of Iran. ss-hosseiny@sbu.ac.ir
authors.forename: Saied Saeed Hosseiny
authors.initials: SS
authors.lastname: Davarani
authors.forename: Leila
authors.initials: L
authors.lastname: Masoomi
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Banitaba
authors.forename: Hamid Reza Lotfi Zadeh
authors.initials: HR
authors.lastname: Zhad
authors.forename: Omid
authors.initials: O
authors.lastname: Sadeghi
authors.forename: Azam
authors.initials: A
authors.lastname: Samiei
mesh_terms: D000536:Aluminum Hydroxide / Q000737:chemistry*; D003358:Cosmetics / Q000737:chemistry*; D004052:Diethylnitrosamine / Q000031:analogs & derivatives* / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D052617:Solid Phase Microextraction / Q000379:methods*
chemical_list: D003358:Cosmetics; C014129:N-nitrosodiethanolamine; D004052:Diethylnitrosamine; D000536:Aluminum Hydroxide