title: Neglected evidence in idiopathic pulmonary fibrosis: from history to earlier diagnosis.
abstract: This perspective highlights some evidence that has hitherto been neglected, especially because it may not have been sufficiently explicated in the clinical respiratory medicine literature. Idiopathic pulmonary fibrosis (IPF) has appeared only in the second half of the 20th century and, like lung cancer and chronic obstructive pulmonary disease, may be a direct consequence of the cigarette smoking epidemic. It is a disease of lung ageing, with most affected patients being >70 years of age. The relationship between lung ageing and pulmonary fibrosis is further illustrated in the bleomycin mouse model, in which older males develop more fibrosis than young female mice. Earlier diagnosis of IPF is a prerequisite for significant progress to be made in the long-term outcome and prognosis. We consider that only two different yet complementary and realistic approaches could lead to earlier diagnosis of IPF and possibly to allowing more efficient disease management: 1) investigating any patients with early Velcro crackles at lung auscultation through proactive education of, and commitment from, primary care physicians; and 2) using current large-scale lung cancer screening strategies with low-dose high-resolution computed tomography in smokers for the detection of subclinical interstitial lung disease and especially early IPF.
authors.affiliation: Competence Centre for Pulmonary Hypertension, Dept of Respiratory Medicine, University of Lyon, University Claude Bernard Lyon 1, INRA, UMR754, IFR 128, Lyon, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Cordier
authors.forename: Vincent
authors.initials: V
authors.lastname: Cottin
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000818:Animals; D001314:Auscultation; D001761:Bleomycin / Q000737:chemistry; D004195:Disease Models, Animal; D005260:Female; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D008168:Lung / Q000473:pathology*; D008297:Male; D008403:Mass Screening; D051379:Mice; D008875:Middle Aged; D011014:Pneumonia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D011379:Prognosis; D015272:Pulmonary Medicine / Q000266:history; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D014057:Tomography, X-Ray Computed
chemical_list: D001761:Bleomycin