title: Effects of PPP1R13L and CD3EAP variants on lung cancer susceptibility among nonsmoking Chinese women.
abstract: The pathogenesis of lung cancer in the never-smokers could possibly be different from the one in smokers. PPP1R13L and CD3EAP on chromosome 19q13.3 are mainly involved in apoptosis and transcription. PPP1R13L and CD3EAP variants may be associated with cancer risk. We addressed the effects of variants/haplotypes of PPP1R13L rs1970764 and CD3EAP rs967591 and rs735482 on susceptibility of lung cancer among nonsmoking Chinese women. A hospital-based case-control study consisted of 79 lung cancer cases and 108 cancer-free controls matched by age (±3years), gender, ethnicity and lifetime never-smoking. Genotyping and statistical analysis were performed by using the method of ligase detection reaction coupled with polymerase chain reaction (LDR-PCR) and SHEsis program and SPSS software. The presence of variant A-allele for CD3EAP rs967591 was associated with increased lung cancer risk [GA versus GG, OR (95% CI)=2.53 (1.16-5.48), P=0.02 and GA+AA versus GG, OR (95% CI)=2.46 (1.16-5.20), P=0.02]. Both D' values and r(2) values accorded with marker distances on chromosome 19q13.3. No associations were found for two other individual SNPs and haplotype distributions of three markers in the whole or single. In conclusion, this study suggests that CD3EAP rs967591 variant allele carriers are at increased susceptibility of lung cancer among nonsmoking Chinese women.
authors.affiliation: Key Laboratory of Environment and Population Health of Liaoning Education Ministry (Shenyang Medical College), Shenyang 110034, Liaoning Province, People's Republic of China. yinjye@163.com
authors.forename: Jiaoyang
authors.initials: J
authors.lastname: Yin
authors.forename: Li
authors.initials: L
authors.lastname: Guo
authors.forename: Chunhong
authors.initials: C
authors.lastname: Wang
authors.forename: Huiwen
authors.initials: H
authors.lastname: Wang
authors.forename: Yegang
authors.initials: Y
authors.lastname: Ma
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Duohong
authors.initials: D
authors.lastname: Liang
authors.forename: Jian
authors.initials: J
authors.lastname: Ma
authors.forename: Yudan
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D016001:Confidence Intervals; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006239:Haplotypes; D006579:Heterozygote; D006761:Hospitals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012318:RNA Polymerase I; D012097:Repressor Proteins / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C119612:PPP1R13L protein, human; D012097:Repressor Proteins; C119975:POLR1G protein, human; D012318:RNA Polymerase I