title: The protective effects of β-cryptoxanthin on inflammatory bone resorption in a mouse experimental model of periodontitis.
abstract: We examined the effects of β-cryptoxanthin, a typical carotenoid, on inflammatory periodontitis. β-Cryptoxanthin suppressed lipopolysaccharide (LPS)-induced osteoclast formation in co-cultures of bone marrow cells and osteoblasts. In a mouse model of periodontitis, it suppressed bone resorption in the mandibular alveolar bone in vitro and restored alveolar bone loss induced by LPS in vivo. β-Cryptoxanthin might protect against periodontal disease.
authors.affiliation: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Chiho
authors.initials: C
authors.lastname: Matsumoto
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ashida
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Tominari
authors.forename: Michiko
authors.initials: M
authors.lastname: Hirata
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ogawa
authors.forename: Minoru
authors.initials: M
authors.lastname: Sugiura
authors.forename: Masamichi
authors.initials: M
authors.lastname: Yano
authors.forename: Masaki
authors.initials: M
authors.lastname: Inada
authors.forename: Chisato
authors.initials: C
authors.lastname: Miyaura
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D001862:Bone Resorption / Q000188:drug therapy*; D065366:Cryptoxanthins; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D041681:NIH 3T3 Cells; D010006:Osteoblasts / Q000187:drug effects / Q000473:pathology; D010010:Osteoclasts / Q000187:drug effects / Q000473:pathology; D010518:Periodontitis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D024341:Xanthophylls / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D065366:Cryptoxanthins; D024341:Xanthophylls