title: Radiolabeling approaches of nanoparticles with (99m) Tc.
abstract: Nanomedicine applications have recently gathered great attention in terms of their revolutionary properties and multivalency. Nanoparticles (NPs) have proven useful owing to their size, surface and kinetics advantages, as well as their ability to be functionalized with targeting, imaging and therapeutic moieties. Nuclear medicine is actively involved in nano-research innovative breakthrough efforts in multiple applications, through the radiolabeling of NP structures. There are several ways that NP-radiolabeling can be approached depending on the radionuclide that is used and the NP type. The radiolabeling of NPs with the most widely and easily available radiometal, which is (99m) Tc, is the focus of this review.
authors.affiliation: Department of Nuclear Medicine, University Hospital of Larissa, 41110, Mezourlo, Larissa, Greece. dpsimad@chem.uoa.gr
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Psimadas
authors.forename: Penelope
authors.initials: P
authors.lastname: Bouziotis
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Georgoulias
authors.forename: Varvara
authors.initials: V
authors.lastname: Valotassiou
authors.forename: Theodoros
authors.initials: T
authors.lastname: Tsotakos
authors.forename: George
authors.initials: G
authors.lastname: Loudos
mesh_terms: D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D011868:Radioisotopes / Q000737:chemistry*; D013667:Technetium / Q000737:chemistry*
chemical_list: D011868:Radioisotopes; D013667:Technetium