title: Novel therapeutic targets for nonalcoholic fatty liver disease.
abstract: BACKGROUND
  Nonalcoholic fatty liver disease (NAFLD) is a serious public health problem. It is now estimated to affect 30% of adults and about 10% of children in the U.S. Hispanics are disproportionably affected with not only higher rates of NAFLD but also more severe disease. Treatment options are currently limited.
  
  
  METHODS
  In this review, we will focus on a series of novel findings related to the pathobiology of liver damage in nonalcoholic steatohepatitis (NASH) that are attractive targets for development of novel therapeutic strategies for human NASH. In particular, we will discuss four different areas due to their novelty and growing importance including microparticles, the inflammasomes, gut-liver axis and dietary lipids.
  
  
  CONCLUSIONS
  There is an urgent need to develop novel safe and effective therapies for the growing NAFLD epidemic. The data discussed in this article provide strong rational to think out of the box when considering novel therapeutic targets for patients with NAFLD.
authors.affiliation: Rady Children's Hospital, Department of Pediatric Gastroenterology, University of California-San Diego, CA 92123, USA. afeldstein@ucsd.edu
authors.forename: Akiko
authors.initials: A
authors.lastname: Eguchi
authors.forename: Davide
authors.initials: D
authors.lastname: Povero
authors.forename: Naim
authors.initials: N
authors.lastname: Alkhouri
authors.forename: Ariel E
authors.initials: AE
authors.lastname: Feldstein
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D055252:Cell-Derived Microparticles / Q000378:metabolism; D004041:Dietary Fats; D005234:Fatty Liver / Q000378:metabolism*; D006801:Humans; D054795:Incretins / Q000378:metabolism; D058847:Inflammasomes / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease
chemical_list: D001647:Bile Acids and Salts; D004041:Dietary Fats; D054795:Incretins; D058847:Inflammasomes