title: Optic neuritis: from magnocellular to cognitive residual dysfunction.
abstract: Optic Neuritis (ON) has been associated to both parvocellular dysfunction and to an alteration of the magnocellular pathway. After objective visual field and acuity recovery, ON patients may complain about their vision suggesting a residual subclinical deficit. To better characterize visual abnormalities, 8 patients recovering from a first ON episode as well as 16 healthy controls performed a simple detection task and a more complex categorization task of images presented in low spatial frequencies (to target the magnocellular system) or in high spatial frequencies (to target the parvocellular system) or of non-filtered images. When completing the tasks with their (previously) pathologic eye, optic neuritis patients showed lower accuracy compared to controls or to their healthy eye for low spatial frequency images only. Conjointly, the longest reaction times were observed with the previously pathologic eye regardless the type of images and to a greater extent in the categorization task than in the detection task. Such data suggest two distinct, although associated, types of residual dysfunction in ON: a magnocellular pathway alteration and a more general (magno and parvocellular) visual dysfunction that could implicate the cognitive levels of visual processing.
authors.affiliation: Unité Fonctionnelle Vision et Cognition, Fondation Ophtalmologique Rothschild, Paris, France Service de Neurologie, Fondation Ophtalmologique Rothschild, Paris, France.
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Viret
authors.forename: Céline
authors.initials: C
authors.lastname: Cavézian
authors.forename: Olivier
authors.initials: O
authors.lastname: Coubard
authors.forename: Vivien
authors.initials: V
authors.lastname: Vasseur
authors.forename: Noa
authors.initials: N
authors.lastname: Raz
authors.forename: Netta
authors.initials: N
authors.lastname: Levin
authors.forename: Catherine
authors.initials: C
authors.lastname: Vignal
authors.forename: Olivier
authors.initials: O
authors.lastname: Gout
authors.forename: Sylvie
authors.initials: S
authors.lastname: Chokron
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D009902:Optic Neuritis / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D010775:Photic Stimulation; D011597:Psychomotor Performance; D011930:Reaction Time; D014795:Visual Pathways; D014796:Visual Perception