title: Effects of uncoupling protein 2 -866G/A polymorphism on platelet reactivity and prognosis in Chinese patients with type 2 diabetes and ischemic stroke.
abstract: The purpose of this study was to assess the effects of -866G>A polymorphism of mitochondrial uncoupling protein 2 (UCP-2) on platelet reactivity and prognosis in patients with type 2 diabetes and ischemic stroke (IS). A total of 405 Chinese patients with type 2 diabetes and stroke were assessed in a 4-year follow-up case-control study. Patient response to antiplatelet therapy was measured with the Platelet Function Analyzer-100 by means of collagen/adenosine diphosphate (CADP) and collagen/epinephrine (CEPI) cartridges. The primary end point was a composite of stroke and TIA (transient ischemic attack), the secondary end point was death. The -866G>A polymorphism in UCP-2 was genotyped by TaqMan MGB probe method. The -866G>A SNP in UCP-2 was not significantly associated with recurrence of diabetic ischemical stroke (p = 0.57). A significant trend toward nonfull response to antiplatelet therapy was seen in patients carrying A allel in comparison with those carrying GG genotype, as shown by the CADP and CEPI tests (p < 0.0001). Our 4-year follow-up study shows no association between -866G>A variant of UCP-2 in type 2 diabetes and the risk of developing stroke. But in conclusion, the A allel is associated with clopidogrel resistance.
authors.affiliation: 1Department of Anatomy Histology and Pharmacology, State Key Laboratory of Pharmaceutical Biotechnology, Laboratory of Neuropharmacology, School of Life Sciences, Nanjing University , Nanjing , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chai
authors.forename: Bing
authors.initials: B
authors.lastname: Gu
authors.forename: Jin-Rong
authors.initials: JR
authors.lastname: Qiu
authors.forename: Hong-Gang
authors.initials: HG
authors.lastname: Yi
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhu
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Hu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D002545:Brain Ischemia / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D015539:Platelet Activation / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011379:Prognosis; D012008:Recurrence; D020521:Stroke / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D000071246:Uncoupling Protein 2
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2