title: [Diagnostic approach to flogosis: procalcitonin validity].
abstract: OBJECTIVE
  The aim of our study was to compare the potential usefulness of procalcitonin with the CRP as a diagnostic marker of pediatric diseases and to define the diagnostic accuracy and relation with the inflammation etiology and severity of procalcitonin.
  
  
  METHODS
  The analysis focused on a sample of 141 children, hospitalized for fever with bacterial, viral or inflammatory etiology, studied at the time of admission in the Hospital, and after defervescence. The sensitivity, the specificity, the positive and negative predictive value have been calculated for the both tests, explained above.
  
  
  RESULTS
  The diagnostic accuracy of procalcitonin is the same as the one of PCR in all cases. The result of the test has been positive in 85.7% of the serious infections and has been useful to identify the etiology of infections in almost 2/3 of patients.
  
  
  CONCLUSIONS
  Procalcitonin seems to be a promising marker of infections because of its following features: a larger contribution in the monitoring phase (fast positivization and normalization); the diagnostic accuracy and a good correlation with the etiology and the severity of infections. Nonetheless, the routine use of procalcitonin is not recommended in the light of the uncertainty on the optimal cut-off and the still high costs.
authors.affiliation: Clinica Pediatrica dell'Università Politecnica delle Marche, Ancona, Italia. elisadim@libero.it
authors.forename: E
authors.initials: E
authors.lastname: Dimitri
authors.forename: V
authors.initials: V
authors.lastname: Amialyanchyk
authors.forename: G
authors.initials: G
authors.lastname: D'Angelo
authors.forename: F
authors.initials: F
authors.lastname: Bordicchia
authors.forename: O
authors.initials: O
authors.lastname: Gabrieli
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000097:blood* / Q000175:diagnosis* / Q000382:microbiology; D008297:Male; D011498:Protein Precursors / Q000097:blood*
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide