title: Taraxacum official (dandelion) leaf extract alleviates high-fat diet-induced nonalcoholic fatty liver.
abstract: The purpose of this study is to determine the protective effect of Taraxacum official (dandelion) leaf extract (DLE) on high-fat-diet (HFD)-induced hepatic steatosis, and elucidate the molecular mechanisms behind its effects. To determine the hepatoprotective effect of DLE, we fed C57BL/6 mice with normal chow diet (NCD), high-fat diet (HFD), HFD supplemented with 2g/kg DLE DLE (DL), and HFD supplemented with 5 g/kg DLE (DH). We found that the HFD supplemented by DLE dramatically reduced hepatic lipid accumulation compared to HFD alone. Body and liver weights of the DL and DH groups were significantly lesser than those of the HFD group, and DLE supplementation dramatically suppressed triglyceride (TG), total cholesterol (TC), insulin, fasting glucose level in serum, and Homeostatic Model Assessment Insulin Resistance (HOMA-IR) induced by HFD. In addition, DLE treatment significantly increased activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) in liver and muscle protein. DLE significantly suppressed lipid accumulation in the liver, reduced insulin resistance, and lipid in HFD-fed C57BL/6 mice via the AMPK pathway. These results indicate that the DLE may represent a promising approach for the prevention and treatment of obesity-related nonalcoholic fatty liver disease.
authors.affiliation: Research Division Emerging Innovative Technology, Korea Food Research Institute, Songnam, Keongki 463-746, Republic of Korea.
authors.forename: Munkhtugs
authors.initials: M
authors.lastname: Davaatseren
authors.forename: Haeng Jeon
authors.initials: HJ
authors.lastname: Hur
authors.forename: Hye Jeong
authors.initials: HJ
authors.lastname: Yang
authors.forename: Jin-Taek
authors.initials: JT
authors.lastname: Hwang
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Park
authors.forename: Hyun-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Kwon
authors.forename: Mi Jeong
authors.initials: MJ
authors.lastname: Sung
mesh_terms: D000263:Adenylate Kinase / Q000378:metabolism; D000818:Animals; D015153:Blotting, Western; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D059305:Diet, High-Fat; D004789:Enzyme Activation; D005234:Fatty Liver / Q000209:etiology / Q000517:prevention & control*; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D047311:Luteolin / Q000032:analysis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D065626:Non-alcoholic Fatty Liver Disease; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D031205:Taraxacum / Q000737:chemistry*
chemical_list: D007328:Insulin; D008055:Lipids; D010936:Plant Extracts; D000263:Adenylate Kinase; D005947:Glucose; D047311:Luteolin
keywords: AMPK; Fatty liver; High-fat diet; Insulin resistance; Taraxacum official (dandelion)