title: [Research progress of N-Myc roles in hematopoiesis and hematologic malignancies].
abstract: N-Myc oncogene plays an important role in the process of hematopoietic cell proliferation and differentiation in embryos. Once the body suffers from hematologic malignancies, the expression of N-Myc would increase and significantly associate with disease progression. In this article the structure of N-Myc, the regulatory mechanism in the different hematopoietic lineages, the interaction in each signal pathways, the transgenic animal model of overexpression, and intervention by drugs are reviewed.
authors.affiliation: Department of Hematology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Li-Jing
authors.initials: LJ
authors.lastname: Shen
authors.forename: Lan-Fang
authors.initials: LF
authors.lastname: Cao
authors.forename: Fang-Yuan
authors.initials: FY
authors.lastname: Chen
mesh_terms: D019337:Hematologic Neoplasms; D006410:Hematopoiesis; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*
chemical_list: D016271:Proto-Oncogene Proteins c-myc