title: A dynamic model for intracellular calcium response in fibroblasts induced by electrical stimulation.
abstract: Regulation of intracellular calcium ion concentration ([Ca(2+)]in) in fibroblasts induced by exogenous electrical stimulation could be applied to control gene expressions selectively which in turn modulate the function of the fibroblasts. Regarding the mechanism for electric-field-induced Ca(2+) influx via voltage-gated Ca(2+) channels and/or stretch-activated cation channels in the fibroblasts, a dynamic mathematical model is proposed to quantify the [Ca(2+)]in dynamics in response to direct current or alternating current electric fields. Simulation results demonstrate that the changes in [Ca(2+)]in predicted by our dynamic model are consistent with the experimental data in the literature. The proposed dynamic model could provide not only more insights into the electric-field-induced intracellular Ca(2+) response but also a quantitative way to regulate the [Ca(2+)]in dynamics by controlling the external electrical stimulation.
authors.affiliation: Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, No. 2, Linggong Rd., Dalian 116024, China.
authors.forename: Guo-Xin
authors.initials: GX
authors.lastname: Sun
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Wang
authors.forename: Cheng
authors.initials: C
authors.lastname: Xiang
authors.forename: Kai-Rong
authors.initials: KR
authors.lastname: Qin
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D002986:Clinical Trials as Topic; D004558:Electric Stimulation; D055724:Electrophysiological Phenomena / Q000502:physiology*; D005347:Fibroblasts / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D056004:Molecular Dynamics Simulation
chemical_list: D002118:Calcium