title: Garlic (Allium sativum) attenuate glomerular glycation in streptozotocin-induced diabetic rats: A possible role of insulin.
abstract: OBJECTIVE
  This study investigated the effect of fresh garlic aqueous extract on glomerular glycation in streptozotocin-induced diabetic rats.
  
  
  METHODS
  Serum insulin and glucose, in addition to renal corpuscles and erythrocyte hemoglobin glycation were determined in normal saline-treated normal rats (NS-NR), normal saline-treated diabetic rats (NS-DR) and garlic-treated diabetic rats (G-DR).
  
  
  RESULTS
  Compared to NS-NR, NS-DR showed significant decrease in serum insulin and increase in serum glucose and hemoglobin glycation. NS-DR also showed intense, diffused glomerular periodic acid Schiff activity. Compared to NS-DR, G-DR showed significant increase in serum insulin and decrease in serum glucose and hemoglobin glycation. Furthermore, the G-DR glomerular periodic acid Schiff activity and distribution was almost restored to that observed in NS-NR.
  
  
  CONCLUSIONS
  Garlic may attenuate glomerular glycation in streptozotocin-induced diabetic rats. This effect could be partially mediated via euglycemia induced by revitalization of endogenous insulin.
authors.affiliation: Department of Biological Sciences, Faculty of Science, Kuwait University, P.O. Box 5969, Alsafat 13060, Kuwait. Electronic address: khaled.alqattan@ku.edu.kw.
authors.forename: Khaled K
authors.initials: KK
authors.lastname: Al-Qattan
authors.forename: Martha
authors.initials: M
authors.lastname: Thomson
authors.forename: Muslim
authors.initials: M
authors.lastname: Ali
authors.forename: Mohamed H
authors.initials: MH
authors.lastname: Mansour