title: Carbonic anhydrase IX in the prediction of right ventricular dysfunction in patients with hemodynamically stable acute pulmonary embolism.
abstract: Right ventricular dysfunction (RVD) defined by echocardiography and/or by natriuretic peptides is a well-known predictor of prognosis in patients with pulmonary embolism (PE). This study investigated carbonic anhydrase IX (CA IX) levels for predicting echocardiographic RVD in patients with PE. A total of 150 normotensive patients with PE were included. The levels of CA IX, N-terminal pro-brain-type natriuretic peptide (NT-proBNP), and high-sensitive cardiac troponin T were significantly elevated in patients with PE with RVD on echocardiography. A receiver-operating characteristic curve analysis showed a value of 0.751 for CA IX, 0.714 for NT-proBNP, and 0.650 for high-sensitive troponin-T to predict RVD on echocardiography. The cutoff value to predict RVD was 32.45 pg/mL for CA IX (sensitivity: 89.3% and specificity: 51.1%). There was a significant positive correlation between the CA IX level and the systolic pulmonary arterial pressure on echocardiography (ρ = .21; P = .035). The CA IX is a significant serologic predictor of RVD in acute PE and correlates with systolic pulmonary arterial pressure.
authors.affiliation: Department of Pulmonary Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey abulyasin@yahoo.com.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Abul
authors.affiliation: Department of Pulmonary Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Savas
authors.initials: S
authors.lastname: Ozsu
authors.affiliation: Medical Laboratory Program, Vocational School of Health Sciences, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Mentese
authors.affiliation: Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Ismet
authors.initials: I
authors.lastname: Durmus
authors.affiliation: Department of Pulmonary Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Hayriye
authors.initials: H
authors.lastname: Bektas
authors.affiliation: Department of Pulmonary Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Mehtap
authors.initials: M
authors.lastname: Pehlivanlar
authors.affiliation: Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Oguzhan Ekrem
authors.initials: OE
authors.lastname: Turan
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Sumer
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Asim
authors.initials: A
authors.lastname: Orem
authors.affiliation: Department of Pulmonary Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Ozlu
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases / Q000097:blood*; D004452:Echocardiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011655:Pulmonary Embolism / Q000150:complications* / Q000503:physiopathology; D020107:Troponin T / Q000097:blood; D018497:Ventricular Dysfunction, Right / Q000097:blood / Q000201:enzymology / Q000209:etiology* / Q000503:physiopathology
chemical_list: D000951:Antigens, Neoplasm; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; C089226:CA9 protein, human; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases
keywords: carbonic anhydrase IX; pulmonary embolism; right ventricular dysfunction