title: Comparative evaluation of oral and dermal cypermethrin exposure on antioxidant profile in Bubalus bubalis.
abstract: Cypermethrin, a type II synthetic pyrethroid insecticide, @ 0.5mg/kg/day for 14 consecutive weeks produced mild signs of toxicity in buffalo calves. Significant changes were observed in various antioxidant parameters in blood. There was a marked increase in the extent of lipid peroxidation (33.9%) and enzymic activity of glutathione peroxidase (6.7%), superoxide dismutase (35.0%), catalase (43.7%), glutathione-S-transferase (64.4%), glutathione reductase (36.7%) and glucose-6-phosphate dehydrogenase (32.1%). A significant decrease in blood glutathione (16.7%), total antioxidant activity (45.4%) and vitamin E (40.8%) was observed and no significant effect was found on blood selenium levels. However, the extent of lipid peroxidation (42%) and the depletion of glutathione (28.8%) was greater after dermal sub-acute toxicity of cypermethrin (0.25%) for 14 consecutive days. Similarly, it was observed that the incline in the enzymic activity of glutathione peroxidase (29.7%), superoxide dismutase (38.3%) and glutathione reductase (38.3%) was higher in dermally cypermethrin exposed animals. Thus, the present investigation contemplates that oxidative stress is the important mechanisms involved in cypermethrin-induced toxicity and the oxidative insult produced by dermal route is more severe as compared to oral intoxication.
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana 141 004, India. Electronic address: rajdeepkaur@gadvasu.in.
authors.forename: Rajdeep
authors.initials: R
authors.lastname: Kaur
authors.forename: Shabir Ahmad
authors.initials: SA
authors.lastname: Dar
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002020:Buffaloes / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D011722:Pyrethrins / Q000008:administration & dosage* / Q000633:toxicity*; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
chemical_list: D000975:Antioxidants; D007306:Insecticides; D011722:Pyrethrins; D014810:Vitamin E; C017160:cypermethrin; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase
keywords: Buffalo; Cypermethrin; Dermal; Oral; Oxidative stress; Toxicity