title: Association of bone mineral density with albuminuria and estimated glomerular filtration rate: the Dong-gu Study.
abstract: BACKGROUND
  Kidney dysfunction and albuminuria may be associated with BMD. However, little evidence has been reported on relationships between BMD and eGFR and albuminuria.
  
  
  METHODS
  A total of 8,992 subjects aged 50 years or older participated in a survey conducted. Participants had their lumbar spine and femoral neck BMD measured by a Lunar Prodigy bone densitometer (GE, Madison, WI). Kidney function was assessed using MDRD eGFR and diagnosis of albuminuria was based on albumin-creatinine ratio.
  
  
  RESULTS
  ACR was negatively associated with lumbar spine and femur neck BMD in females (lumbar spine: 1.001, 0.988, 0.974 and 0.979 g/cm(2), p < 0.001; femur neck: 0.796, 0.790, 0.783 and 0.782 g/cm(2), p = 0.002), but not in males, after adjusting for covariates. Additionally, eGFR was shown to be negatively associated with lumbar spine BMD after adjusting for covariates (male: 1.181, 1.166, 1.152 and 1.149 g/cm(2), p = 0.001; female: 0.997, 0.980, 0.979 and 0.982 g/cm(2), p = 0.005), but demonstrated no association with femur BMD.
  
  
  CONCLUSIONS
  ACR in females was negatively associated with lumbar spine and femur neck BMD, but not in males. eGFR was negatively associated with lumbar spine BMD in both males and females.
authors.affiliation: Department of Preventive Medicine, Chosun University Medical School, 375, Seosuk-dong, Gwangju 501-759, Republic of Korea.
authors.forename: Seong-Woo
authors.initials: SW
authors.lastname: Choi
authors.forename: Hye-Yeon
authors.initials: HY
authors.lastname: Kim
authors.forename: Hye-Ran
authors.initials: HR
authors.lastname: Ahn
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Lee
authors.forename: Sun-Seog
authors.initials: SS
authors.lastname: Kweon
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Choi
authors.forename: Jung-Ae
authors.initials: JA
authors.lastname: Rhee
authors.forename: Hae-Sung
authors.initials: HS
authors.lastname: Nam
authors.forename: Seul-Ki
authors.initials: SK
authors.lastname: Jeong
authors.forename: Kyeong-Soo
authors.initials: KS
authors.lastname: Park
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Ryu
authors.forename: Hye-Rim
authors.initials: HR
authors.lastname: Song
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000473:pathology* / Q000503:physiopathology; D015519:Bone Density / Q000502:physiology*; D003404:Creatinine / Q000097:blood; D005260:Female; D005272:Femur Neck / Q000473:pathology; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007677:Kidney Function Tests; D008159:Lumbar Vertebrae / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D056910:Republic of Korea; D012727:Sex Characteristics
chemical_list: D003404:Creatinine