title: Relationship between expression of EGFR in gastric cancer tissue and clinicopathological features.
abstract: OBJECTIVE
  To investigate the relationship between the expression of epidermal growth factor receptor (EGFR) in gastric cancer and the clinicopathological features and prognosis.
  
  
  METHODS
  A total of 78 paraffin specimens of gastric cancer operation were collected. The immunohistochemical method was used to detect the expression of EGFR in 78 cases of gastric cancer and 20 cases of adjacent normal tissue. The relationship between the high expression of EGFR and clinicopathological features was analyzed.
  
  
  RESULTS
  EGFR positive expression rate in the 78 cases of gastric cancer tissue was 57.7 % (45/78), while EGFR was not expressed in 20 cases of adjacent normal tissue. The high EGFR expression was positively correlated with the position of gastric cancer, tumor size, cell differentiation, invasive depth, lymph node metastasis and TNM staging, yet having no obvious relation with gender or age.
  
  
  CONCLUSIONS
  EGFR expression level in gastric cancer is closely related to the incidence and development of gastric cancer, which can provide a theoretical basis for the targeted therapy for gastric cancer with EGFR as the target.
authors.affiliation: Oncology Department, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. gaohaoming033@163.com
authors.forename: Ming
authors.initials: M
authors.lastname: Gao
authors.forename: Xiu-Ju
authors.initials: XJ
authors.lastname: Liang
authors.forename: Zi-Sen
authors.initials: ZS
authors.lastname: Zhang
authors.forename: Wang
authors.initials: W
authors.lastname: Ma
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Chang
authors.forename: Ming-Zhi
authors.initials: MZ
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D047368:Tumor Burden; D055815:Young Adult
chemical_list: D066246:ErbB Receptors