title: A palladium/chiral amine co-catalyzed enantioselective dynamic cascade reaction: synthesis of polysubstituted carbocycles with a quaternary carbon stereocenter.
abstract: Polysubstituted 5- and 6-membered carbocycles were synthesized by the title reaction. The one-pot dynamic relay process generates four new stereocenters, including a quaternary carbon center, in a highly enantioselective fashion (99.5:0.5→99:0.5 e.r.) by using a simple combination of palladium and chiral amine co-catalysts.
authors.affiliation: Department of Natural Sciences, Engineering and Mathematics, Mid Sweden University, 85170 Sundsvall, Sweden.
authors.forename: Guangning
authors.initials: G
authors.lastname: Ma
authors.forename: Samson
authors.initials: S
authors.lastname: Afewerki
authors.forename: Luca
authors.initials: L
authors.lastname: Deiana
authors.forename: Carlos
authors.initials: C
authors.lastname: Palo-Nieto
authors.forename: Leifeng
authors.initials: L
authors.lastname: Liu
authors.forename: Junliang
authors.initials: J
authors.lastname: Sun
authors.forename: Ismail
authors.initials: I
authors.lastname: Ibrahem
authors.forename: Armando
authors.initials: A
authors.lastname: Córdova
mesh_terms: D000447:Aldehydes; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006844:Hydrocarbons, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D020836:Protein Structure, Quaternary; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000588:Amines; D006844:Hydrocarbons, Cyclic; D010165:Palladium