title: Ambulatory blood pressure and blood lipids in a multiethnic sample of healthy adults.
abstract: OBJECTIVE
  Elevated blood pressure (BP), elevated serum cholesterol, and aberrant lipoprotein fractions (low levels of high-density lipoprotein (HDL) and high levels of low-density lipoprotein fractions and triglycerides) have all been used as measures that assess the "metabolic syndrome" and more recently in indexes of allostatic load, which are designed to assess the degree of integrated metabolic pathology. While there are ample data regarding the interrelationships of these measures in various pathophysiological settings, there are limited data regarding the interrelationship of ambulatory BP (ABP) and blood lipids in healthy subjects. The present study evaluates ABP-blood lipid relationships in a multiethnic sample of healthy adults.
  
  
  METHODS
  The subjects were 37 men (age = 40.9 ± 10.7 years) and 42 women (age = 35.8 ± 10.4 years) who were employed as hotel workers in Hawaii. Each wore an ABP monitor for one midweek workday and had pressures averaged in three daily microenvironments (work, home, and during sleep). They also had fasting blood samples taken for lipid profiling.
  
  
  RESULTS
  Multivariate analysis of covariance shows that there was a strong inverse relationship between HDL and both systolic (P < 0.006) and diastolic (P < 0.006) BP, overall and in each microenvironment, but no statistically significant relationships with other lipid measures.
  
  
  CONCLUSIONS
  These results suggest lipids and BP do not act as a group in healthy adults but that higher HDL is associated with lower BP. This latter finding is consistent with research that shows that HDL promotes vasodilation via its effect on endothelial nitric oxide synthase.
authors.affiliation: Decker School of Nursing and Department of Anthropology, Binghamton University, Binghamton, NY 13902, USA. gdjames@binghamton.edu
authors.forename: Gary D
authors.initials: GD
authors.lastname: James
authors.forename: Helene M
authors.initials: HM
authors.lastname: Van Berge-Landry
authors.forename: Lynn A
authors.initials: LA
authors.lastname: Morrison
authors.forename: Angela M
authors.initials: AM
authors.lastname: Reza
authors.forename: Nicola M
authors.initials: NM
authors.lastname: Nicolaisen
authors.forename: James R
authors.initials: JR
authors.lastname: Bindon
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Brown
mesh_terms: D000328:Adult; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D044469:Racial Groups
chemical_list: D008055:Lipids