title: Marginal zone lymphomas with monocytoid morphology express T-bet and are associated with a low number of T cells in extranodal locations.
abstract: The presence of tumor cells with monocytoid morphology in marginal zone lymphoma (MZL) has been described previously. Reactive monocytoid B cells bear a distinct immunophenotype and typically express T-bet, which clearly distinguishes them from nodal marginal zone B cells. The latter are positive for CD27 and negative for T-bet. We analyzed 74 MZLs for the expression of T-bet and correlated these results with the presence of monocytoid morphology. Expression of T-bet correlated with the presence of monocytoid morphology in MZLs. In analogy to reactive monocytoid B lymphocytes, we also found a significantly lower relative amount of intratumoral T lymphocytes in extranodal MZL with monocytoid morphology.
authors.affiliation: Institute of Pathology, Charité Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Lohneis
authors.forename: Stephan
authors.initials: S
authors.lastname: Wienert
authors.forename: Frederick
authors.initials: F
authors.lastname: Klauschen
authors.forename: Andrea
authors.initials: A
authors.lastname: Ullrich
authors.forename: Ioannis
authors.initials: I
authors.lastname: Anagnostopoulos
authors.forename: Korinna
authors.initials: K
authors.lastname: Jöhrens
mesh_terms: D015870:Gene Expression; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D009000:Monocytes / Q000378:metabolism* / Q000473:pathology*; D013154:Spleen / Q000378:metabolism / Q000473:pathology; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism*; D013601:T-Lymphocytes / Q000473:pathology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000235:genetics / Q000378:metabolism; D000098815:T-bet Transcription Factor
chemical_list: D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7