title: Successful treatment of plasmacytosis circumorificialis with topical tacrolimus: two case reports and an immunohistochemical study.
abstract: Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Interestingly, immunohistochemical staining revealed that prominent CD163(+) proinflammatory macrophages and IL-17-producing cells were infiltrating around plasma cells, which might suggest the reason for the therapeutic effect of topical tacrolimus on PLC.
authors.affiliation: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Fujimura
authors.forename: Sadanori
authors.initials: S
authors.lastname: Furudate
authors.forename: Masaya
authors.initials: M
authors.lastname: Ishibashi
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kambayashi
authors.forename: Gen-Ichi
authors.initials: G
authors.lastname: Tojo
authors.forename: Chihiro
authors.initials: C
authors.lastname: Wakusawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mayama
authors.forename: Setsuya
authors.initials: S
authors.lastname: Aiba
keywords: CD163+ macrophages; IL-17; Plasmacytosis circumorificialis; Proinflammatory cytokine; Tacrolimus