title: Evaluation of MRI fat fraction in the liver and spine pre and post SPIO infusion.
abstract: This study evaluates the robustness of a magnetic resonance (MR) fat quantification method to changes in R2* caused by an intravenous infusion of superparamagnetic iron oxide (SPIO) contrast agent. The R2* and proton density fat fraction (PDFF) were measured in liver and spine in 14 subjects using an investigational sequence (IDEAL IQ) provided by the MR scanner vendor. Measurements were made before and after SPIO infusion. Results showed SPIO significantly increased R2* in both liver (p=8.8×10(-8)) and spine (p=1.3×10(-2)) but PDFFs were not significantly different in either the liver (p=5.5×10(-1)) or the spine (p=5.6×10(-1)). These results confirm that the IDEAL IQ method of fat quantification is robust to changes in R2*.
authors.affiliation: University of California San Diego, San Diego, CA 92103-8226, USA. jliau@ucsd.edu
authors.forename: Joy
authors.initials: J
authors.lastname: Liau
authors.forename: Masoud
authors.initials: M
authors.lastname: Shiehmorteza
authors.forename: Olivier M
authors.initials: OM
authors.lastname: Girard
authors.forename: Claude B
authors.initials: CB
authors.lastname: Sirlin
authors.forename: Mark
authors.initials: M
authors.lastname: Bydder
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000473:pathology*; D050154:Adiposity / Q000187:drug effects; D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage; D003911:Dextrans / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008107:Liver Diseases / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D064887:Observational Studies as Topic; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013131:Spine / Q000187:drug effects* / Q000473:pathology*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; C097921:ferumoxtran-10