title: The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors.
abstract: Anti-Müllerian hormone (AMH) has both paracrine and hormonal actions that occur at different AMH concentrations, and in cells with different densities of its specific receptor (Amhr2). This diversity is not explained by canonical AMH signaling. We report that Amhr2 has two splice variants: Amhr2Δ2 (AMH binding site) and Amhr2Δ9/10 (kinase domain). Both spliced variants inhibit AMH signaling in a reporter assay. The mRNA for the spliced variants was relatively less abundant than Amhr2 mRNA in all tissues. This suggests that the physiological function(s) of the receptor variants may be restricted to specific cellular/subcellular sites and/or to the transport of AMH.
authors.affiliation: Department of Anatomy, University of Otago, Dunedin 9054, New Zealand.
authors.forename: Floriane M
authors.initials: FM
authors.lastname: Imhoff
authors.forename: Dee
authors.initials: D
authors.lastname: Yang
authors.forename: Suneeth F
authors.initials: SF
authors.lastname: Mathew
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Clarkson
authors.forename: Yui
authors.initials: Y
authors.lastname: Kawagishi
authors.forename: Warren P
authors.initials: WP
authors.lastname: Tate
authors.forename: Kyoko
authors.initials: K
authors.lastname: Koishi
authors.forename: Ian S
authors.initials: IS
authors.lastname: McLennan
mesh_terms: D000818:Animals; D054304:Anti-Mullerian Hormone / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005786:Gene Expression Regulation; D017930:Genes, Reporter / Q000235:genetics; D008297:Male; D051379:Mice; D009928:Organ Specificity; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D051381:Rats; D018000:Receptors, Peptide / Q000235:genetics / Q000378:metabolism*; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D020033:Protein Isoforms; D018000:Receptors, Peptide; D018125:Receptors, Transforming Growth Factor beta; C084621:anti-Mullerian hormone receptor; D054304:Anti-Mullerian Hormone