title: Diffusion weighted imaging with background body signal suppression / T2 image fusion in magnetic resonance mammography for breast cancer diagnosis.
abstract: BACKGROUND
  Dynamic Contrast-Enhanced Magnetic Resonance Mammography (DCE-MRM) represents the most sensitive examination for breast cancer (BC) diagnosis. However literature data reports very inhomogeneous specificity. The aim of our study was to evaluate the clinical efficiency of a new MRM technique - diffusion weighted imaging with background body signal suppression T2 image fusion in BC diagnosis, compared to DCE-MRM.
  
  
  METHODS
  We retrospectively analyzed 50 consecutive DCE-MRM examinations with DWIBS sequence from the archives of the Department of Radiology, Lyon Sud Hospital, (02.2010- 02.2011), summing up to 64 breast lesions. Fusions were created using the Osirix software from the DWIBS images (b=1000 s mm2) and their T2 correspondents. Interpretation was performed using an adapted BI-RADS system. The final histopathological examination or a minimum 6-months follow-up served as gold standard.
  
  
  RESULTS
  Out of the 64 examined breast lesions, 35(54.7%) were classified as malignant by DCE-MRM and 24(37.5%) cases by DWIBS T2, respectively. Thus the DWIBS T2 fusion had a Sensitivity of 62.5%(95%CI:35.4-84.8) and a Specificity of 70.8%(95%CI:55.9-83.3) while DCE-MRM had a higher Sensitivity: 87.5%(95%CI:61.6-98.4) but a lower Specificity: 56.2%(95%CI:41.1-70.5).
  
  
  CONCLUSIONS
  DWIBS T2 fusion is an innovative MRM technique, with a specificity superior to DCE-MRM, showing a large potential for improving the clinical efficiency of classical MRM.
authors.affiliation: Târgu Mureş University of Medicine and Pharmacy, Department of Radiology and Medical Imaging, Târgu Mureş, Romania. nechiforalin@yahoo.com
authors.forename: I A
authors.initials: IA
authors.lastname: Nechifor-Boilă
authors.forename: S
authors.initials: S
authors.lastname: Bancu
authors.forename: M
authors.initials: M
authors.lastname: Buruian
authors.forename: M
authors.initials: M
authors.lastname: Charlot
authors.forename: M
authors.initials: M
authors.lastname: Decaussin-Petrucci
authors.forename: J-S
authors.initials: JS
authors.lastname: Krauth
authors.forename: A C
authors.initials: AC
authors.lastname: Nechifor-Boilă
authors.forename: A
authors.initials: A
authors.lastname: Borda
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media