title: Catalyst-free, one-pot, three-component synthesis of 5-amino-1,3-aryl-₁Η-pyrazole-4-carbonitriles in green media.
abstract: An efficient, one-pot, three-component synthesis of various biologically important heterocyclic compounds is described via a tandem Knoevengel-cyclo condensation reaction of aromatic aldehydes, malono derivatives, and phenyl hydrazine derivatives in water and ethanol at room temperature.
authors.affiliation: Department of Chemistry, Faculty of Sciences, Persian Gulf University, 75169 , Bushehr, Iran. a_hasaninejad@yahoo.com
authors.forename: Alireza
authors.initials: A
authors.lastname: Hasaninejad
authors.forename: Somayeh
authors.initials: S
authors.lastname: Firoozi
mesh_terms: D002384:Catalysis; D055808:Drug Discovery; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D011720:Pyrazoles