title: Rolling circle amplification-based DNA origami nanostructrures for intracellular delivery of immunostimulatory drugs.
abstract: Several single-stranded scaffold DNA, obtained from rolling circle amplification (RCA), are folded by different staples to form DNA nanoribbons. These DNA nanoribbons are rigid, simple to design, and cost-effective drug carriers, which are readily internalized by mammalian cells and show enhanced immunostimulatory activity.
authors.affiliation: Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
authors.forename: Xiangyuan
authors.initials: X
authors.lastname: Ouyang
authors.forename: Jiang
authors.initials: J
authors.lastname: Li
authors.forename: Huajie
authors.initials: H
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.forename: Juan
authors.initials: J
authors.lastname: Yan
authors.forename: Yinzhou
authors.initials: Y
authors.lastname: Ma
authors.forename: Shoujun
authors.initials: S
authors.lastname: Xiao
authors.forename: Shiping
authors.initials: S
authors.lastname: Song
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
authors.forename: Jie
authors.initials: J
authors.lastname: Chao
authors.forename: Chunhai
authors.initials: C
authors.lastname: Fan
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D004247:DNA / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*
chemical_list: D000276:Adjuvants, Immunologic; D004337:Drug Carriers; D037742:Nanotubes, Carbon; D004247:DNA
keywords: DNA nanostructures; DNA origami; cellular uptake; drug delivery; rolling circle amplification