title: Association of the rs3077 and rs9277535 polymorphisms in HLA-DP with hepatitis B virus infection and spontaneous clearance: a meta-analysis.
abstract: OBJECTIVE
  Owing to inconsistent observations in the literature of an association between HLA-DP polymorphisms (rs3077 and rs9277535) and hepatitis B virus (HBV) infection and spontaneous clearance, there is an urgent need for a comprehensive and reliable understanding of this subject. This meta-analysis was performed to quantitatively summarise the evidence for the relevance of these HLA-DP polymorphisms to HBV infection and spontaneous clearance.
  
  
  METHODS
  A meta-analysis was conducted with the data from eight relevant papers published from April 2009 to March 2012, following strict selection. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for alleles, co-dominant, dominant and recessive genotype models of the rs3077 and rs9277535 loci.
  
  
  RESULTS
  Our analysis indicated a significant association of rs3077 and rs9277535 in HLA-DP with HBV infection, suggesting that these HLA-DP polymorphisms act beneficially against HBV infection (for rs3077, AG vs. GG: OR = 0.522, 95% CI = 0.485-0.561; AA vs. GG: OR = 0.350, 95% CI = 0.311-0.393; for rs9277535, AG vs. GG: OR = 0.542, 95% CI = 0.506-0.579; AA vs. GG: OR = 0.371, 95% CI = 0.336-0.409). Additionally, these HLA-DP polymorphisms served as protective factors in the spontaneous clearance of HBV (for rs3077, AG vs. GG: OR = 0.600, 95% CI = 0.464-0.775; AA vs. GG: OR = 0.420, 95% CI = 0.299-0.590; for rs9277535, AG vs. GG: OR = 0.623, 95% CI = 0.570-0.681 and AA vs. GG: OR = 0.464, 95% CI = 0.386-0.556) with similar results for both dominant and recessive genotype models.
  
  
  CONCLUSIONS
  Our results demonstrated that the rs3077 and rs9277535 HLA-DP polymorphisms reduced HBV infection and increased the likelihood of spontaneous viral clearance in some Asian populations.
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Zhongshan East Road 361#, Shi Jiazhuang 050017, China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Zhang
authors.forename: Xiao-Chen
authors.initials: XC
authors.lastname: Ni
authors.forename: Jin-Hai
authors.initials: JH
authors.lastname: Jia
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Dong
authors.forename: Feng-Xue
authors.initials: FX
authors.lastname: Yu
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.forename: Xue-Hui
authors.initials: XH
authors.lastname: Liu
authors.forename: Man
authors.initials: M
authors.lastname: Li
authors.forename: Dian-Wu
authors.initials: DW
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics*; D005838:Genotype; D006682:HLA-DP Antigens / Q000235:genetics*; D006509:Hepatitis B / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012075:Remission, Spontaneous
chemical_list: D006682:HLA-DP Antigens