title: Collagen-only biomatrix as dural substitute: What happened after a 5-year observational follow-up study.
abstract: OBJECTIVE
  To assess long-term efficacy of the collagen-only biomatrix as a dural substitute in a large case series.
  
  
  METHODS
  We reviewed a prospectively acquired database of patients who underwent neurosurgical surgeries in whom the dural substitute was used and who were the subject of two previous studied with shorter follow-ups.
  
  
  RESULTS
  The present study was conducted on 111 subjects of the original 209 patients. No late complications, nor local or systemic toxicity were observed during the observational period. As a matter of facts, 5 patients (4.5%) underwent reoperation for different reasons and 2 out of 5 experienced subcutaneous fluid collections; another case (0.9%), already reported in our previous studies, developed a CSF leak after an endoscopic endonasal operation for an intra-suprasellar arachnoid cyst.
  
  
  CONCLUSIONS
  Our data further confirm that the collagen-only biomatrix derived from horse equine tendon is a safe and effective dural substitute for routine neurosurgical procedures.
authors.affiliation: Department of Neurosciences and Reproductive and Odontostomatological Sciences, Division of Neurosurgery, Università degli Studi di Napoli Federico II, Naples, Italy. felice.esposito@unina.it
authors.forename: Felice
authors.initials: F
authors.lastname: Esposito
authors.forename: Gianluca
authors.initials: G
authors.lastname: Grimod
authors.forename: Luigi M
authors.initials: LM
authors.lastname: Cavallo
authors.forename: Luigi
authors.initials: L
authors.lastname: Lanterna
authors.forename: Francesco
authors.initials: F
authors.lastname: Biroli
authors.forename: Paolo
authors.initials: P
authors.lastname: Cappabianca
mesh_terms: D000328:Adult; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000601:surgery; D065634:Cerebrospinal Fluid Leak; D002559:Cerebrospinal Fluid Rhinorrhea / Q000453:epidemiology; D003094:Collagen / Q000627:therapeutic use*; D004388:Dura Mater; D005260:Female; D015718:Fibrin Tissue Adhesive; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures; D011184:Postoperative Period; D011446:Prospective Studies; D012086:Reoperation; D014014:Tissue Adhesives; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D003094:Collagen
keywords: Biocompatibility; Collagen; Dura; Dura mater regeneration