title: Pharmacokinetics of meprobamate in overdose treated with continuous venovenous hemodiafiltration (CVVHDF).
abstract: We report a case of massive suicidal overdose of meprobamate leading to cardiovascular collapse, respiratory failure, and severe central nervous system depression. We observed first-order elimination kinetics despite significant overdose, and demonstrated effectiveness of continuous venovenous hemodiafiltration (CVVHDF) for extracorporeal removal of meprobamate in this patient. Total body clearance was calculated to be 87 mL/minute, with 64 mL/minute (74%) due to CVVHDF. CVVHDF was stopped after 36 hours, and the patient made an uneventful recovery.
authors.affiliation: Swiss Toxicological Information Centre, Associated Institute of the University of Zurich, Zurich, Switzerland.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ceschi
authors.forename: David
authors.initials: D
authors.lastname: Berger
authors.forename: Michael
authors.initials: M
authors.lastname: Dickenmann
authors.forename: Michael
authors.initials: M
authors.lastname: Bodmer
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000378:metabolism / Q000628:therapy*; D062787:Drug Overdose / Q000188:drug therapy* / Q000378:metabolism*; D005260:Female; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D008620:Meprobamate / Q000493:pharmacokinetics* / Q000506:poisoning*; D008875:Middle Aged; D013406:Suicide, Attempted
chemical_list: D008620:Meprobamate
keywords: CVVHDF; Poisoning; hemodiafiltration; meprobamate