title: Glucose biosensors based on a gold nanodendrite modified screen-printed electrode.
abstract: In this study, an enzymatic glucose biosensor based on a three-dimensional gold nanodendrite (GND) modified screen-printed electrode was developed. The GNDs were electrochemically synthesized on the working electrode component of a commercially available screen-printed electrode using a solution acquired by dissolving bulk gold in aqua regia as the precursor. The 3D GND electrode greatly enhanced the effective sensing area of the biosensor, which improved the sensitivity of glucose detection. Actual glucose detections demonstrated that the fabricated devices could perform at a sensitivity of 46.76 μA mM⁻¹ cm⁻² with a linear detection range from 28 μM-8.4 mM and detection limit of 7 μM. A fast response time (∼3 s) was also observed. Moreover, only a 20 μl glucose oxidase is required for detection owing to the incorporation of the commercially available screen-printed electrode.
authors.affiliation: Department of Mechanical Engineering, National Chung-Hsing University, Taichung 40227, Taiwan.
authors.forename: Hsi-Chien
authors.initials: HC
authors.lastname: Liu
authors.forename: Chung-Che
authors.initials: CC
authors.lastname: Tsai
authors.forename: Gou-Jen
authors.initials: GJ
authors.lastname: Wang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D003460:Crystallization / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D005949:Glucose Oxidase / Q000032:analysis / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D008839:Microelectrodes; D036103:Nanotechnology / Q000295:instrumentation*; D010316:Particle Size; D013499:Surface Properties
chemical_list: D006046:Gold; D005949:Glucose Oxidase; D005947:Glucose