title: Molecular mechanisms of deoxynivalenol resistance in the yeastSaccharomyces cerevisiae.
abstract: The production of trichothecene toxins is a suspected virulence mechanism of several plant pathogenic fungi. This hypothesis has been confirmed forGibberella zeae (Fusarium graminearum) by gene disruption experiments, suggesting in turn, that resistance against the fungal toxin is a relevant component ofFusarium resistance of the host plant. Our goal is therefore to identify molecular mechanisms of trichothecene resistance. Using yeast as a model system we have found the following resistance mechanisms and genes: a) reduced uptake of deoxynivalenol (PDR5), b) toxin modification and reduction of toxicity (AYT1), and c) formation of a resistant toxin target (RPL3). Homologous plant genes exist and are attractive candidates forFusarium resistance genes.
authors.affiliation: Center of Applied Genetics, University of Agricultural Sciences, Vienna, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Adam
authors.forename: R
authors.initials: R
authors.lastname: Mitterbauer
authors.forename: A
authors.initials: A
authors.lastname: Raditschnig
authors.forename: B
authors.initials: B
authors.lastname: Poppenberger
authors.forename: T
authors.initials: T
authors.lastname: Karl
authors.forename: S
authors.initials: S
authors.lastname: Goritschnig
authors.forename: H
authors.initials: H
authors.lastname: Weindorfer
authors.forename: J
authors.initials: J
authors.lastname: Glössl