title: BODIPY-based fluorometric sensor array for the highly sensitive identification of heavy-metal ions.
abstract: A BODIPY(4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)-based fluorometric sensor array has been developed for the highly sensitive detection of eight heavy-metal ions at micromolar concentration. The di-2-picolyamine (DPA) derivatives combine high affinities for a variety of heavy-metal ions with the capacity to perturb the fluorescence properties of BODIPY, making them perfectly suitable for the design of fluorometric sensor arrays for heavy-metal ions. 12 cross-reactive BODIPY fluorescent indicators provide facile identification of the heavy-metal ions using a standard chemometric approach (hierarchical clustering analysis); no misclassifications were found over 45 trials. Clear differentiation among heavy-metal ions as a function of concentration was also achieved, even down to 10(-7)M. A semi-quantitative interpolation of the heavy-metal concentration is obtained by comparing the total Euclidean distance of the measurement with a set of known concentrations in the library.
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, CAS, Beijing 100190, PR China.
authors.forename: Li-Ya
authors.initials: LY
authors.lastname: Niu
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Feng
authors.forename: Ying-Shi
authors.initials: YS
authors.lastname: Guan
authors.forename: Yu-Zhe
authors.initials: YZ
authors.lastname: Chen
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Duan
authors.forename: Li-Zhu
authors.initials: LZ
authors.lastname: Wu
authors.forename: Ya-Feng
authors.initials: YF
authors.lastname: Guan
authors.forename: Chen-Ho
authors.initials: CH
authors.lastname: Tung
authors.forename: Qing-Zheng
authors.initials: QZ
authors.lastname: Yang
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D002852:Chromatography, Ion Exchange; D005456:Fluorescent Dyes / Q000737:chemistry*; D005470:Fluorometry; D007477:Ions / Q000737:chemistry; D019216:Metals, Heavy / Q000032:analysis* / Q000302:isolation & purification; D046228:Microarray Analysis; D014867:Water / Q000737:chemistry
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D007477:Ions; D019216:Metals, Heavy; D014867:Water