title: Single nucleotide polymorphisms in the u-PA gene are related to susceptibility to oral tongue squamous cell carcinoma in the Northern Chinese Han population.
abstract: OBJECTIVE
  The purpose of this study was to determine whether susceptibility to oral tongue squamous cell carcinoma (OSCC) is related to polymorphisms in the u-PA gene.
  
  
  METHODS
  We examined the rs2227564 C/T and rs2227562 G/A single nucleotide polymorphisms (SNPs) in 196 OSCC patients and 201 age- and gender- matched controls via direct sequencing and PCR-RFLP methods.
  
  
  RESULTS
  Significant differences were found in allelic and genotypic distributions of the rs2227564 and rs2227562 loci when comparing cases and controls. In addition, logistic analyses indicated that the rs2227564 C/T genotype was related to a 1.52-fold increased risk of developing OSCC (adjusted OR=1.521, 95%CI: 1.144~2.022, P=0.004). Linkage disequilibrium analysis was conducted and no association between the two loci was found (D'=0.031, r2=0.000).
  
  
  CONCLUSIONS
  Our findings provide evidence that the rs2227564 C/T SNP in the u-PA gene is associated with the development of OSCC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Medical College, Qingdao University, Shandong, China. xuecaiyang011@163.com
authors.forename: Feng
authors.initials: F
authors.lastname: Zhong
authors.forename: Xue-Cai
authors.initials: XC
authors.lastname: Yang
authors.forename: Ling-Xue
authors.initials: LX
authors.lastname: Bu
authors.forename: Ning-Yi
authors.initials: NY
authors.lastname: Li
authors.forename: Wan-Tao
authors.initials: WT
authors.lastname: Chen
mesh_terms: D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D014062:Tongue Neoplasms / Q000235:genetics*; D014568:Urokinase-Type Plasminogen Activator / Q000235:genetics*
chemical_list: D014568:Urokinase-Type Plasminogen Activator