title: Nutraceuticals for metabolic syndrome management: from laboratory to benchside.
abstract: Metabolic syndrome (MetS) is a world-wide epidemic disease associated with increased morbidity and mortality. Treatment strategies include pharmacologic and non-pharmacologic methods, with varying degrees of success rate all over the world. Pharmaceutical interest in this field is growing, together with patients' requests for supplementary (or "alternative") treatments. The knowledge of nutraceuticals beneficial effects in subjects with the MetS could help us to better define the appropriate treatment for these subjects, in particular those with contraindications for commonly used drugs, or to achieve guidelines suggested targets. On the other side, it could be not convenient to use a nutraceutical to treat each metabolic syndrome component (i.e. from 3 to 5) in each affected subjects. Thus, this review tries to focus on widely marketed nutraceuticals with clinically demonstrated effects on more than one component of the MetS, namely omega-3 fatty acids, berberine, psyllium and other soluble fibers, cinnamon, chromium picolinate, banaba, and bitter gourd.
authors.forename: Arrigo F
authors.initials: AF
authors.lastname: Cicero
authors.forename: Elisa
authors.initials: E
authors.lastname: Tartagni
authors.affiliation: Sant'Orsola-Malpighi University Hospital, Padiglione 2, Via Albertoni 15, 40138 Bologna-Italy. arrigo.cicero@unibo.it.
authors.forename: Sibel
authors.initials: S
authors.lastname: Ertek
mesh_terms: D000818:Animals; D001599:Berberine / Q000008:administration & dosage / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002935:Cinnamomum zeylanicum / Q000737:chemistry; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D031563:Lagerstroemia / Q000737:chemistry; D024821:Metabolic Syndrome / Q000188:drug therapy*; D029777:Momordica charantia / Q000737:chemistry; D010848:Picolinic Acids / Q000008:administration & dosage / Q000627:therapeutic use; D028321:Plant Preparations / Q000008:administration & dosage / Q000627:therapeutic use; D011620:Psyllium / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D015525:Fatty Acids, Omega-3; D010848:Picolinic Acids; D028321:Plant Preparations; D001599:Berberine; D011620:Psyllium; C030614:picolinic acid