title: Bison meat has a lower atherogenic risk than beef in healthy men.
abstract: The rearing method of bison and the nutrient content of the meat may make bison a healthier alternative to beef. We hypothesized that the acute and chronic effects of bison consumption, in comparison to beef, will result in a less perturbed blood lipid panel and a reduced inflammatory and oxidative stress response which will minimize the detrimental effect on vascular function. A double-blind, cross-over randomized trial was employed to examine the consequence of a single 12 oz serving (n = 14) and 7 weeks of chronic consumption (n = 10) (12 oz/d, 6 d/wk) of each meat. Measurements included blood lipids, interleukin-6, plasminogen activator inhibitor 1, C-reactive protein, oxidized low-density lipoprotein, protein carbonyl, hydroperoxides, flow-mediated dilation (FMD) and FMD/shear rate. Following a single beef meal, triglycerides and oxidized low-density lipoprotein were elevated (67% ± 45% and 18% ± 17% respectively); there was a tendency for hydroperoxides to be elevated (24% ± 37%); and FMD/shear rate was reduced significantly (30% ± 38%). Following a single meal of bison: there was a smaller increase in triglycerides (30% ± 27%), and markers of inflammation and oxidative stress and FMD/shear rate were unchanged. Chronic consumption of either meat did not influence body weight, % body fat, or blood lipids. Protein carbonyl (24% ± 45%), plasminogen activator inhibitor 1 (78% ± 126%), interleukin-6 (59% ± 76%) and C-reactive protein (72% ± 57%) were significantly elevated and FMD/shear rate was significantly reduced (19% ± 28%) following 7 weeks of beef consumption, but not bison consumption. Based on our findings, the data suggest that bison consumption results in a reduced atherogenic risk compared to beef.
authors.affiliation: Louis Stokes Cleveland VA Medical Center, Cleveland, OH 44106, USA. John.McDaniel@va.gov
authors.forename: John
authors.initials: J
authors.lastname: McDaniel
authors.forename: Wayne
authors.initials: W
authors.lastname: Askew
authors.forename: Danielle
authors.initials: D
authors.lastname: Bennett
authors.forename: Jason
authors.initials: J
authors.lastname: Mihalopoulos
authors.forename: Sujata
authors.initials: S
authors.lastname: Anantharaman
authors.forename: Anette S
authors.initials: AS
authors.lastname: Fjeldstad
authors.forename: Dan C
authors.initials: DC
authors.lastname: Rule
authors.forename: Nazeem M
authors.initials: NM
authors.lastname: Nanjee
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Harris
authors.forename: Russell S
authors.initials: RS
authors.lastname: Richardson
mesh_terms: D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood; D016164:Bison; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002417:Cattle; D018592:Cross-Over Studies; D004032:Diet; D004311:Double-Blind Method; D005227:Fatty Acids / Q000032:analysis; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D007249:Inflammation / Q000517:prevention & control; D015850:Interleukin-6 / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008460:Meat / Q000009:adverse effects / Q000032:analysis*; D008875:Middle Aged; D009043:Motor Activity; D009753:Nutritive Value; D018384:Oxidative Stress; D050050:Protein Carbonylation; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005227:Fatty Acids; D015850:Interleukin-6; D008077:Lipoproteins, LDL; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein; D006861:Hydrogen Peroxide