title: Intradermal therapy (mesotherapy) with lymdiaral in chronic venous insufficiency and associated fibrosclerotic edema damage: a pilot study.
abstract: OBJECTIVE
  Chronic venous insufficiency (CVI) induces alterations that cause fibrosclerotic edema of the subcutaneous tissue. This study examined the effects of a complex naturopathic compound with vasoactive and antiedema activities (Lymdiaral®) administered intradermally.
  
  
  METHODS
  40 patients with signs and symptoms of CVI and associated fibrosclerotic edema of the subcutaneous tissue.
  
  
  METHODS
  Efficacy was assessed by using clinical investigation, subjective and objective measures, and ultrasonography performed at baseline and after treatment.
  
  
  RESULTS
  Thirty-four patients completed the study; 6 of the original 40 (15%) had stopped for reasons unrelated to study treatment. The treatment was well tolerated. Fifteen adverse reactions were reported among a total of 378 doses administered (3.97%). None of these reactions were severe or required discontinuation of treatment. Subjective symptoms and objective measures improved, and ultrasonography showed statistically significant changes in hypodermal thickness of the medial aspect of the knees.
  
  
  CONCLUSIONS
  Its open-label design and small sample size notwithstanding, this study indicates that intradermal therapy, according to the recommendation of the Italian Society of Mesotherapy, may provide a valuable contribution to the treatment of CVI and related fibrosclerotic edema of the subcutaneous tissue by prolonging the local effect of the pharmacologically active compounds. Comparative studies are needed to identify the broader clinical and economic benefits of local therapy compared with other systemic therapies.
authors.affiliation: 1 Clinical Research of the Service of Aesthetic Medicine , Ospedale Generale San Giovanni Calibita Fatebenefratelli, Isola Tiberina, Rome, Italy .
authors.forename: Enrica
authors.initials: E
authors.lastname: Maggiori
authors.forename: Emanuele
authors.initials: E
authors.lastname: Bartoletti
authors.forename: Massimo
authors.initials: M
authors.lastname: Mammucari
mesh_terms: D000328:Adult; D002908:Chronic Disease; D029982:Conium; D004487:Edema / Q000188:drug therapy*; D005260:Female; D006801:Humans; D039321:Hydrastis; D007866:Leg / Q000098:blood supply; D057748:Mesotherapy / Q000379:methods*; D029603:Phytolacca; D008517:Phytotherapy / Q000379:methods*; D010865:Pilot Projects; D028321:Plant Preparations / Q000494:pharmacology*; D011446:Prospective Studies; D031445:Scilla; D016896:Treatment Outcome; D014689:Venous Insufficiency / Q000188:drug therapy*; D028182:Viscum album
chemical_list: C585108:Lymdiaral; D028321:Plant Preparations