title: Comparative study on the larvicidal activity of drimane sesquiterpenes and nordrimane compounds against Drosophila melanogaster til-til.
abstract: Natural compounds from Drimys winteri Forst and derivatives exhibited larvicidal effects against Drosophila melanogaster til-til. The most active compound was isodrimenin (4). The highest lethal concentration to the larvae of D. melanogaster was 4.5 ± 0.8 mg/L. At very low concentrations drimenol (1), confertifolin (3), and drimanol (5) displayed antifeedant and larvae growth regulatory activity. The antifeedant results of nordrimanic and drimanic compounds were better in first instar larvae. The EC₅₀ value of polygodial (2) was 60.0 ± 4.2 mg/L; of diol 15 45.0 ± 2.8 mg/L, and of diol 17 36.9 ± 3.7 mg/L, while the new nordrimane compound 12 presented a value of 83.2 ± 3.5 mg/L.
authors.affiliation: Departamento de Química, Universidad Técnica Federico Santa María, Av. España N° 1680, Valparaíso 2340000, Chile. ivan.montenegro@postgrado.usm.cl
authors.forename: Ivan
authors.initials: I
authors.lastname: Montenegro
authors.forename: Luis
authors.initials: L
authors.lastname: Pino
authors.forename: Enrique
authors.initials: E
authors.lastname: Werner
authors.forename: Alejandro
authors.initials: A
authors.lastname: Madrid
authors.forename: Luis
authors.initials: L
authors.lastname: Espinoza
authors.forename: Luis
authors.initials: L
authors.lastname: Moreno
authors.forename: Joan
authors.initials: J
authors.lastname: Villena
authors.forename: Mauricio
authors.initials: M
authors.lastname: Cuellar
mesh_terms: D000818:Animals; D032424:Drimys / Q000737:chemistry; D004331:Drosophila melanogaster / Q000187:drug effects*; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D010936:Plant Extracts; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane; C034380:polygodial