title: Preliminary feasibility, acceptability, and efficacy of an innovative adherence intervention for children with newly diagnosed epilepsy.
abstract: OBJECTIVE
  To report acceptability, feasibility, and preliminary efficacy from a randomized controlled trial of a family-tailored adherence intervention (AI) targeting nonadherence to antiepileptic drugs in pediatric new-onset epilepsy.
  
  
  METHODS
  30 children with new-onset epilepsy (7.2 ± 3.1 years old, 47% male) and their caregivers participated. At baseline, participants were given adherence electronic monitors. After a 1-month run-in period, participants with good adherence (≥90%) were monitored. Participants with adherence <90% were randomized to the AI or Treatment-As-Usual (TAU) group. The AI group received four adherence promotion intervention sessions over >2 months. Follow-up adherence data were collected.
  
  
  RESULTS
  8 families were randomized (AI, n = 4; TAU, n = 4). Families perceived AI to be feasible and acceptable. Preliminary results demonstrated that the AI group had improved adherence from baseline to post-test.
  
  
  CONCLUSIONS
  A family-tailored AI appears promising and needs to be tested with a larger pediatric epilepsy sample.
authors.affiliation: Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA. avani.modi@cchmc.org
authors.forename: Avani C
authors.initials: AC
authors.lastname: Modi
authors.forename: Shanna M
authors.initials: SM
authors.lastname: Guilfoyle
authors.forename: Joseph
authors.initials: J
authors.lastname: Rausch
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D017028:Caregivers; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants
keywords: adherence; chronic illness; neurological disorders; randomized controlled trial