title: Association between bile acid turnover and osteoporosis in postmenopausal women.
abstract: OBJECTIVE
  The intestinal absorption of vitamin D is linked to bile acid absorption. This link may be abnormal in patients with osteoporosis. The aim of this study was to investigate a possible relation between osteoporosis and bile acid turnover, measured as whole-body Se-75-HCAT retention (WBR), in postmenopausal women.
  
  
  METHODS
  Whole-body counts were recorded using an uncollimated gamma camera 3 h and 7 days after oral administration of Se-75-homocholic acid taurine (Se-75-HCAT) in 16 women aged 58-85 years with dual-photon X-ray absorptiometry (DEXA)-proven osteoporosis. WBR was expressed as physical decay-corrected counts at 7 days as a percentage of the counts at 3 h.
  
  
  RESULTS
  Seven patients had unexplained diarrhoea. Six patients (five with diarrhoea) had WBR less than 19%. There was a significant difference in DEXA t-score between women with and without diarrhoea (P<0.02). There was a significant negative correlation (R s=-0.58; P<0.02) between WBR and alcohol consumption rated on a three-point scale: <1, 2-7 and >7 U/week.
  
  
  CONCLUSIONS
  Our results indicate an association between osteoporosis and diarrhoea that may be the result of abnormal bile acid turnover. The role of alcohol requires further investigation.
authors.affiliation: Department of Medical Physics, Royal Sussex County Hospital, Brighton, UK.
authors.forename: Ruth
authors.initials: R
authors.lastname: Hanly
authors.forename: Nicola
authors.initials: N
authors.lastname: Ryan
authors.forename: Hayley
authors.initials: H
authors.lastname: Snelling
authors.forename: Karen
authors.initials: K
authors.lastname: Walker-Bone
authors.forename: Sabina
authors.initials: S
authors.lastname: Dizdarevic
authors.forename: A Michael
authors.initials: AM
authors.lastname: Peters
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001647:Bile Acids and Salts / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000000981:diagnostic imaging* / Q000378:metabolism*; D011877:Radionuclide Imaging; D013656:Taurocholic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D051598:Whole Body Imaging
chemical_list: D001647:Bile Acids and Salts; D013656:Taurocholic Acid; C033638:23-seleno-25-homotaurocholic acid