title: [Inhibitory effect of human lactoferrin (neolactoferrin) on the growth of transplantable tumor in the uterine cervix of mice].
abstract: There was studied effect of recombinant form of human breast milk component-lactoferrin, received from milk of goats-producers (neolactoferrin), on growth of transplantable tumor of the cervix in mice (TTC-5). Neolactoferrin in dose of 100 mg/kg and 200 mg/kg of animals' mass inhibited the rate of tumor growth. The most effective was the dose of 200 mg/kg, which was entered a week before transplantation. In contrast to the control group, in groups where neolactoferrin was entered it was fixed resorption of TTC-5 in 6 mice. Repeated transplantation TTC-5 to these mice led to reducing of the rate of tumor growth and increasing of duration of their lives. To investigate if tumor-braking effect neolactoferrin connected with direct effect on the tumor or due to the general effect of the organism, TTC-5 cells were transformed in culture and they were exposed by neolactoferrin in dose of 10 and 100 mkg/ml. In investigated doses neolactoferrin did not influence on tumor cells growth. There is discussed possible mechanism of anti-tumor effect of neolactoferrin.
authors.forename: V A
authors.initials: VA
authors.lastname: Kobliakov
authors.forename: E E
authors.initials: EE
authors.lastname: Antoshina
authors.forename: T G
authors.initials: TG
authors.lastname: Gor'kova
authors.forename: I L
authors.initials: IL
authors.lastname: Gol'dman
authors.forename: L S
authors.initials: LS
authors.lastname: Trukhanova
authors.forename: E R
authors.initials: ER
authors.lastname: Sadchikova
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002584:Cervix Uteri / Q000187:drug effects*; D005260:Female; D006801:Humans; D007781:Lactoferrin / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice; D009368:Neoplasm Transplantation; D016019:Survival Analysis; D014183:Transplantation, Heterologous; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control*
chemical_list: D000970:Antineoplastic Agents; D007781:Lactoferrin