title: Small intestine contrast ultrasonography in pediatric Crohn's disease.
abstract: OBJECTIVE
  To evaluate the diagnostic accuracy of small intestine contrast ultrasonography (SICUS) in pediatric Crohn's disease (CD).
  
  
  METHODS
  A total of 51 consecutive patients (median age 15 years; range 3-20, 31 male patients), 21 with suspected and 30 with proven CD, were studied. All patients underwent standard ultrasonography (ie, transabdominal ultrasonography [TUS]), SICUS, small bowel follow-through, and upper and lower endoscopy. SICUS was performed in patients after they ingested an oral contrast solution. TUS and SICUS were compared with small bowel follow-through and endoscopy via use of the final diagnosis as reference standard.
  
  
  RESULTS
  In undiagnosed patients, the sensitivity and specificity of TUS and SICUS in detecting CD small bowel lesions were 75% and 100% and 100% and 100%, respectively. In patients with proven CD, the sensitivity and specificity of TUS and SICUS were 76% and 100% and 96% and 100%, respectively. The agreement (k) with radiology for site of lesions was almost perfect for SICUS (0.93), both for jejunal and ileal lesions, and it was fair (0.40) for jejunal and substantial (0.68) for ileal lesions for TUS. Compared with radiology SICUS correctly assessed the length of lesions, whereas TUS underestimated it (P = .0001).
  
  
  CONCLUSIONS
  The radiation-free technique SICUS is comparable with radiology and more accurate than TUS in assessing small bowel lesions in pediatric CD, mainly in the detection of proximal small bowel disease.
authors.affiliation: Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
authors.forename: Nadia
authors.initials: N
authors.lastname: Pallotta
authors.forename: Fortunata
authors.initials: F
authors.lastname: Civitelli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Nardo
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Vincoli
authors.forename: Marina
authors.initials: M
authors.lastname: Aloi
authors.forename: Franca
authors.initials: F
authors.lastname: Viola
authors.forename: Paolo
authors.initials: P
authors.lastname: Capocaccia
authors.forename: Enrico
authors.initials: E
authors.lastname: Corazziari
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cucchiara
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media; D003424:Crohn Disease / Q000175:diagnosis / Q000000981:diagnostic imaging*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000000981:diagnostic imaging*; D008297:Male; D011092:Polyethylene Glycols; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D003287:Contrast Media; D011092:Polyethylene Glycols
keywords: CD; Crohn's disease; GI; Gastrointestinal; IBD; Inflammatory bowel disease; MR; Magnetic resonance; SBFT; SICUS; Small bowel follow-through; Small intestine contrast ultrasonography; TUS; Transabdominal ultrasonography; US; Ultrasonography