title: Therapeutic plasma-exchange in hematologic disease: results from a single center in Eastern Anatolia.
abstract: Therapeutic plasma-exchange (TPE) is used as primary and adjunctive therapy in treatment of several hematologic diseases. We retrospectively evaluated the results of TPE in hematologic diseases during 2008-2012. A total of 301 TPE procedures were performed in 44 patients (19 male and 25 female, with mean age of 50.6±15years). Fifteen of 44 patients had thrombotic thrombocytopenic purpura (TTP), 14 patients had HELLP syndrome (Hemolysis Elevated Liver enzymes, Low Platelet count), 10 patients had multiple myeloma-hyperviscosity and the rest five patients had snake bite. Fresh frozen plasma (FFP) was used as replacement fluid. Complete response (CR) was achieved on 13 patients (87%) in primarily TTP. CR was achieved in all other three diseases. Total complications were detected in 8.1% of the TPE procedures. Adverse events (AEs), were seen in 5.4% of all procedures. None of the patients died from any complication. AE occurred in 4% (Grade-I), 1% (Grade-II), and 0.3% (Grade-III) of the procedures. The most common AE were nausea/vomiting, hypotension, pruritus and abdominal pain. TPE is effectively and safely carried out in our center in hematologic diseases.
authors.affiliation: Inonu University, Faculty of Medicine, Department of Hematology and Apheresis Unit, Malatya, Turkey. erkurtali@hotmail.com
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Erkurt
authors.forename: Irfan
authors.initials: I
authors.lastname: Kuku
authors.forename: Emin
authors.initials: E
authors.lastname: Kaya
authors.forename: Unsal
authors.initials: U
authors.lastname: Ozgen
authors.forename: Ilhami
authors.initials: I
authors.lastname: Berber
authors.forename: Mustafa
authors.initials: M
authors.lastname: Koroglu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozgül
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D017359:HELLP Syndrome / Q000628:therapy; D006402:Hematologic Diseases / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy; D010949:Plasma; D010951:Plasma Exchange / Q000379:methods*; D011247:Pregnancy; D011697:Purpura, Thrombotic Thrombocytopenic / Q000628:therapy; D012189:Retrospective Studies; D012909:Snake Bites / Q000628:therapy; D016896:Treatment Outcome; D014421:Turkey