title: Metachronous gastrointestinal stromal tumor and acute leukemia after liver transplantation for cholangiocellular carcinoma: is there a link?
abstract: The synchronous or metachronous coexistence of gastrointestinal stromal tumors (GISTs) with solid and hematologic neoplasms has been addressed in a non-transplant population. However, the association with primary hepatic neoplasms and leukemias is uncommon. Scarce data exist considering association of GISTs and other neoplasms in a transplant population where long-term immunosuppression carries the additional burden of de novo malignancy. We present a case of posttransplant metachronous GIST and acute biphenotypic leukemia in a patient transplanted for intrahepatic cholangiocellular carcinoma, emphasizing the possible link between mechanisms of carcinogenesis and influence of other factors upon their development.
authors.affiliation: Department of Medicine, University Hospital Merkur, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Anna
authors.initials: A
authors.lastname: Mrzljak
authors.forename: Iva
authors.initials: I
authors.lastname: Košuta
authors.forename: Anita
authors.initials: A
authors.lastname: Škrtić
authors.forename: Ika
authors.initials: I
authors.lastname: Kardum-Skelin
authors.forename: Radovan
authors.initials: R
authors.lastname: Vrhovac
keywords: Acute leukemia; Cholangiocellular carcinoma; Gastrointestinal stromal tumor; Liver transplantation