title: Pd-catalyzed allylic alkylation cascade with dihydropyrans: regioselective synthesis of furo[3,2-c]pyrans.
abstract: A regioselective palladium-catalyzed allylic alkylation cascade forms furo[3,2-c]pyrans from various cyclic β-dicarbonyl bis-nucleophiles and 3,6-dihydro-2H-pyran bis-electrophiles. The combination of allylic carbonate and anomeric siloxy leaving groups in the dihydropyran substrate allows control of the many regiochemical possibilities in this reaction. Annulation proceeds stereoconvergently to give cis-fused furopyrans from either cis- or trans-substituted starting material.
authors.affiliation: School of Chemical and Physical Sciences, Victoria University of Wellington , P.O. Box 600, Wellington, 6140, New Zealand.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Bartlett
authors.forename: Claire A
authors.initials: CA
authors.lastname: Turner
authors.forename: Joanne E
authors.initials: JE
authors.lastname: Harvey