title: First asymmetric synthesis of planar chiral [2.2]metacyclophanes.
abstract: A general three step asymmetric synthesis of planar chiral [2.2]metacyclophanes utilizing selective benzylic and aryl metalations is described. The final enantioselective step is achieved using a (-)-sparteine mediated aryl metalation, following which electrophile reaction gives planar chiral cyclophanes with enantiomeric ratios (er) above 90 : 10.
authors.affiliation: School of Chemistry & Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Marco
authors.initials: M
authors.lastname: Blangetti
authors.forename: Helge
authors.initials: H
authors.lastname: Müller-Bunz
authors.forename: Donal F
authors.initials: DF
authors.lastname: O'Shea