title: Targeted manipulation of apoptotic pathways by using High Intensity Focused Ultrasound in cancer treatment.
abstract: Apoptosis, or programmed cell death, is a mechanism of cell death, which has been exploited for the treatment of cancers over the past few years. The understanding of apoptosis pathways (intrinsic and extrinsic) has led to discovery of treatment strategies which selectively target the cancer cells and spare the normal ones. This article reviews the current understanding of the apoptotic pathways which are utilized for targeting cancer cells using High Intensity Focused Ultrasound (HIFU).
authors.affiliation: Institute for Medical Science and Technology, University of Dundee, Wilson House, 1 Wurzburg Loan, Dundee DD2 1FD, United Kingdom. tim.saliev@gmail.com
authors.forename: Timur
authors.initials: T
authors.lastname: Saliev
authors.forename: Loreto B
authors.initials: LB
authors.lastname: Feril
authors.forename: Ghulam
authors.initials: G
authors.lastname: Nabi
authors.forename: Andreas
authors.initials: A
authors.lastname: Melzer
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D014463:Ultrasonography
keywords: Apoptosis; Bio-effects; High Intensity Focused Ultrasound; MRI