title: α-D-Glucosidase inhibitory activity of polysaccharide isolated from Acacia tortilis gum exudate.
abstract: The study aims to explore the antihyperglycemic activity of Acacia tortilis polysaccharide isolated from the gum exudate. α-d-Glucosidase from Saccharomyces cerevisiae and rat small intestine was used as in vitro model to assess α-d-glucosidase inhibitory activity of the polysaccharide against yeast and mammalian enzyme. The reduction in postprandial blood glucose level after carbohydrate rich diet fed to Albino Wistar rats was employed as in vivo model of α-d-glucosidase inhibition. The study revealed α-d-glucosidase inhibitory activity of the polysaccharide in both in vitro as well as in vivo models. Therefore, polysaccharide isolated from A. tortilis plant gum exudate may be a potential drug for diabetes mellitus and its complications.
authors.affiliation: Chemistry Division, Forest Research Institute, Dehradun 248006, India.
authors.forename: Swati
authors.initials: S
authors.lastname: Bisht
authors.forename: Ravi
authors.initials: R
authors.lastname: Kant
authors.forename: Vineet
authors.initials: V
authors.lastname: Kumar
mesh_terms: D000045:Acacia / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002241:Carbohydrates; D004032:Diet; D065089:Glycoside Hydrolase Inhibitors; D006170:Gum Arabic / Q000737:chemistry*; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D007422:Intestines / Q000737:chemistry / Q000201:enzymology; D008297:Male; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000201:enzymology; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D002241:Carbohydrates; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D011134:Polysaccharides; D006170:Gum Arabic; D000520:alpha-Glucosidases