title: Vesicular mechanisms of traffic of fungal molecules to the extracellular space.
abstract: Fungal cells are efficient in releasing to the extracellular space molecules that lack typical secretion signals, including cytoplasmic components. Studies developed during the last five years indicate that extracellular vesicle formation is involved in the traffic of these intracellular components to the extracellular space. The cellular origin of these vesicles, however, is still unknown. Here we review the potential mechanisms involved in formation of fungal extracellular vesicles and consequent release of fungal molecules to the outer cellular space. We also propose that these compartments can originate from cytoplasmic subtractions whose formation is dependent on plasma membrane reshaping.
authors.affiliation: Fundação Oswaldo Cruz - Fiocruz, Centro de Desenvolvimento Tecnológico em Saúde, Rio de Janeiro, Brazil. marciolr@cdts.fiocruz.br
authors.forename: Marcio L
authors.initials: ML
authors.lastname: Rodrigues
authors.forename: Anderson J
authors.initials: AJ
authors.lastname: Franzen
authors.forename: Leonardo
authors.initials: L
authors.lastname: Nimrichter
authors.forename: Kildare
authors.initials: K
authors.lastname: Miranda
mesh_terms: D055354:Exosomes / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism*; D005658:Fungi / Q000378:metabolism*
chemical_list: D005656:Fungal Proteins