title: Relationship between macrophage differentiation and the chemotactic activity toward damaged myoblast cells.
abstract: We investigated the effect of macrophage differentiation on the chemotactic activity to invade local damaged myoblasts using in vitro models of muscle injury. We found that: 1) the chemotactic activity of macrophages toward areas of damaged myoblasts might be induced more by live myoblasts than dead ones, 2) the chemotactic activity of macrophages is not due to velocity, but depends on the directionality toward damaged myoblast cells, and 3) macrophage differentiation strongly influence the chemotactic activity toward damaged myoblast cells through the expression of CCR2 and/or F-actin.
authors.affiliation: Department of Health and Sports Science, Kawasaki University of Medical Welfare, Kurashiki, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Uchida
authors.forename: Eri
authors.initials: E
authors.lastname: Oyanagi
authors.forename: Motohiko
authors.initials: M
authors.lastname: Miyachi
authors.forename: Akira
authors.initials: A
authors.lastname: Yamauchi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Yano
mesh_terms: D000199:Actins / Q000276:immunology / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D002460:Cell Line; D018932:Chemokine CCL2 / Q000276:immunology / Q000378:metabolism; D002633:Chemotaxis / Q000276:immunology*; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D018482:Muscle, Skeletal / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D009135:Muscular Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D032446:Myoblasts / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D054390:Receptors, CCR2 / Q000276:immunology / Q000378:metabolism
chemical_list: D000199:Actins; C491768:Ccl2 protein, mouse; C515335:Ccr2 protein, mouse; D018932:Chemokine CCL2; D054390:Receptors, CCR2