title: HIV-infected patients show impaired cellular immune response to influenza vaccination compared to healthy subjects.
abstract: Detailed data on cellular immune response to influenza vaccination in HIV-infected patients are lacking. We analyzed cellular (IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IFN-γ, TNF-α, GM-CSF) and humoral (IgG and IgM) immune response in 81 HIV-infected and 30 HIV-negative subjects, before (T0) and 4 weeks (T1) after receiving a single dose of trivalent MF59-adjuvanted influenza vaccine. No difference in humoral response (IgG or IgM) was demonstrated between the two groups. While an increase in most cytokines from T0 to T1 was observed in HIV-uninfected subjects, cytokines production did not significantly increased in HIV-infected patients. Exploring Th1 response, higher CD8 cells count was significantly associated with lower post-vaccination IFNγ levels, while a higher CD4 cells count was associated with a greater response. Exploring Th2 response, higher HIV viral load was significantly associated with reduced post-vaccination IL-10 levels. In conclusion, in HIV-infected patients influenza vaccination could have good efficacy in sustaining humoral response but cellular response appeared impaired.
authors.affiliation: Institute of Clinical Infectious Diseases, Catholic University of Sacred Heart, Largo Agostino Gemelli 8, 00168 Rome, Italy. massifab@alice.it
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Fabbiani
authors.forename: Letizia
authors.initials: L
authors.lastname: Sidella
authors.forename: Maddalena
authors.initials: M
authors.lastname: Corbi
authors.forename: Rosa
authors.initials: R
authors.lastname: Martucci
authors.forename: Michela
authors.initials: M
authors.lastname: Sali
authors.forename: Manuela
authors.initials: M
authors.lastname: Colafigli
authors.forename: Roberto
authors.initials: R
authors.lastname: Cauda
authors.forename: Giovanni
authors.initials: G
authors.lastname: Delogu
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sgambato
authors.forename: Simona
authors.initials: S
authors.lastname: Di Giambenedetto
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D014611:Vaccination
chemical_list: D007252:Influenza Vaccines