title: Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males.
abstract: The seven-factor biopsychosocial model of personality distinguished four biologically based temperaments and three psychosocially based characters. Previous studies have suggested that the four temperaments-novelty seeking (NS), reward dependence (RD), harm avoidance (HA), and persistence (P)-have their respective neurobiological correlates, especially in the striatum-connected subcortical and cortical networks. However, few studies have investigated their neurobiological basis in the form of fiber connectivity between brain regions. This study correlated temperaments with fiber connectivity between the striatum and subcortical and cortical hub regions in a sample of 50 Chinese adult males. Generally consistent with our hypotheses, results showed that: (1) NS was positively correlated with fiber connectivity from the medial and lateral orbitofrontal cortex (mOFC, lOFC) and amygdala to the striatum; (2) RD was positively correlated with fiber connectivity from the mOFC, posterior cingulate cortex/retrosplenial cortex (PCC), hippocampus, and amygdala to the striatum; (3) HA was positively linked to fiber connectivity from the dorsolateral prefrontal cortex (dlPFC) and PCC to the striatum; and (4) P was positively linked to fiber connectivity from the mOFC to the striatum. These results extended the research on the neurobiological basis of temperaments by identifying their anatomical fiber connectivity correlates within the subcortical-cortical neural networks.
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; Department of Psychology and Social Behavior, University of California, Irvine, CA, USA.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Lei
authors.affiliation: Department of Psychology and Social Behavior, University of California, Irvine, CA, USA. Electronic address: Chuansheng.Chen@uci.edu.
authors.forename: Chuansheng
authors.initials: C
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xue
authors.affiliation: Institute of Genomics and Bioinformatics, University of California, Irvine, CA, USA.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: He
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA; Institute of Genomics and Bioinformatics, University of California, Irvine, CA, USA.
authors.forename: Robert K
authors.initials: RK
authors.lastname: Moyzis
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Gui
authors.initials: G
authors.lastname: Xue
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Zhongyu
authors.initials: Z
authors.lastname: Cao
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: He
authors.initials: H
authors.lastname: Li
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Bi
authors.initials: B
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Yuyun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Psychology and Social Behavior, University of California, Irvine, CA, USA.
authors.forename: Anna Shan Chun
authors.initials: AS
authors.lastname: Hsu
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China. Electronic address: dongqi@bnu.edu.cn.
authors.forename: Qi
authors.initials: Q
authors.lastname: Dong
mesh_terms: D000328:Adult; D000679:Amygdala / Q000033:anatomy & histology; D044466:Asian People; D001921:Brain / Q000033:anatomy & histology*; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D003342:Corpus Striatum / Q000033:anatomy & histology*; D056324:Diffusion Tensor Imaging; D006801:Humans; D008297:Male; D009413:Nerve Fibers, Myelinated; D009415:Nerve Net / Q000033:anatomy & histology*; D009434:Neural Pathways; D013694:Temperament; D055815:Young Adult
keywords: DTI; Diffusion tensor imaging; Personality; Striatum; TCI; Temperaments