title: Synchronous ovarian dysgerminoma and breast carcinoma in a patient with positive immunostain of BRCA1.
abstract: Breast cancer is the most common malignant neoplastic process and the second cause of death for women. Ovarian cancer, despite having a lower incidence, represents an important cause of morbidity and mortality because it is usually discovered in advanced stages. The presence of both forms of cancer in a patient is associated with a high risk of BRCA1 gene mutations, which are responsible, together with BRCA2 gene mutations, for most of the breast and ovarian cancer family. Our case is special because it presents a synchronous and a rare association of a primary ovarian dysgerminoma (with an incidence of less than 1% of ovarian cancers) and a primary breast carcinoma in a patient of 46 years old. Immunohistochemical examination was performed using a panel of five biomarkers: oestrogen receptor, progesterone receptor, Herceptest, p53 and BRCA1. In our case, we identified a negative hormonal status and the absence of HER2/neu expression but a positive immuno-expression for p53 protein and BRCA1 protein. Postoperative course was favourable for the patient after each surgery, and she was discharged with the recommendation to perform a genetic counselling.
authors.affiliation: Department of Clinical Pathology, County Emergency Hospital, Constanţia, Romania.
authors.forename: G I
authors.initials: GI
authors.lastname: Băltătescu
authors.forename: M
authors.initials: M
authors.lastname: Așchie
authors.forename: V
authors.initials: V
authors.lastname: Sârbu
mesh_terms: D019313:BRCA1 Protein / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D002277:Carcinoma / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D004407:Dysgerminoma / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D058994:Salpingectomy; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D019313:BRCA1 Protein; D015415:Biomarkers; D016159:Tumor Suppressor Protein p53