title: A randomized placebo-controlled pilot study of Cat saliva 9cH and Histaminum 9cH in cat allergic adults.
abstract: BACKGROUND
  Cat allergy is an abnormal immune response by the body to cat dander or saliva, leading to the development of a complex of symptoms which can negatively influence health. Cat saliva 9cH and Histaminum 9cH are indicated, according to isopathic principles, for the treatment of cat allergy, however no research has been done to date.
  
  
  OBJECTIVE
  To determine the effect of Cat saliva 9cH and Histaminum 9cH (combined) on cat allergic adults.
  
  
  METHODS
  30 Participants with a positive test result for a cat allergy skin prick test (SPT) were recruited to a double-blind, randomised, placebo controlled clinical trial. Participants took two tablets twice daily for 4 weeks, and attended a follow-up consultation at the end of weeks 2 and 4. The measurement tool used was the SPT, conducted at the beginning and at the end of the study.
  
  
  RESULTS
  Cat saliva 9cH and Histaminum 9cH produced a highly statistically significant reduction in the wheal diameter of the cat allergen SPT at the end of week 4. The placebo group showed no statistically significant change.
  
  
  CONCLUSIONS
  The homeopathic medicine reduced the sensitivity reaction of cat allergic adults to cat allergen, according to the SPT. Future studies are warranted to further investigate the effect of Cat saliva and Histaminum and their role as a potential therapeutic option for this condition.
authors.affiliation: Department of Homoeopathy, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, Gauteng, South Africa.
authors.forename: Prenitha
authors.initials: P
authors.lastname: Naidoo
authors.forename: Janice
authors.initials: J
authors.lastname: Pellow
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology; D000818:Animals; D002415:Cats; D003888:Desensitization, Immunologic; D004311:Double-Blind Method; D005260:Female; D006632:Histamine / Q000031:analogs & derivatives* / Q000276:immunology*; D006705:Homeopathy; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012463:Saliva / Q000276:immunology*; D012882:Skin Tests; D055815:Young Adult
chemical_list: D000485:Allergens; D006632:Histamine