title: Antenna design and tissue parameters considerations for an improved modelling of microwave ablation in the liver.
abstract: Microwave ablation is a technique used in treating hepatocellular carcinoma, especially in cases where surgical removal is impossible. In the present study we are investigating the effects of design characteristics of a coaxial slot antenna (single- versus double-slot, slot-to-tip distance and slot size) on the ablation zone characteristics (dimensions and shape). The specific absorption rate field and the temperature rises are calculated for a variety of application times and powers. A plateau in the ablation zone dimensions in healthy and cirrhotic liver models is predicted, but not in malignant ones. It is found that the value of the perfusion rate (which is different for each clinical case) is of crucial importance in order to correctly estimate the ablation zone. An underestimation of dimensions is expected, if higher perfusion rates are used (i.e., values for healthy tissue rather than malignant). In contrast, an exact determination of the values of relative permittivity and conductivity is less significant for predicting the ablation zone.
authors.affiliation: THESS S.A., Technopolis ICT Business Park, 57001 Thessaloniki, Greece. karampatzakis@thess.com.gr
authors.forename: Andreas
authors.initials: A
authors.lastname: Karampatzakis
authors.forename: Sven
authors.initials: S
authors.lastname: Kühn
authors.forename: George
authors.initials: G
authors.lastname: Tsanidis
authors.forename: Esra
authors.initials: E
authors.lastname: Neufeld
authors.forename: Theodoros
authors.initials: T
authors.lastname: Samaras
authors.forename: Niels
authors.initials: N
authors.lastname: Kuster
mesh_terms: D055011:Ablation Techniques / Q000295:instrumentation*; D004867:Equipment Design; D008099:Liver / Q000473:pathology / Q000528:radiation effects*; D008103:Liver Cirrhosis / Q000473:pathology / Q000628:therapy; D008872:Microwaves / Q000627:therapeutic use*; D008954:Models, Biological; D013696:Temperature; D013997:Time Factors