title: [Incidence of erythrocyte alloimmunization in pregnant women in olomouc region].
abstract: OBJECTIVE
  To determine the incidence of clinically significant anti-erythrocyte alloantibodies in pregnant women, which can cause severe hemolytic disease in the fetus and newborn.
  
  
  METHODS
  Retrospective-prospecitive clinical study.
  
  
  METHODS
  Transfusion Department, University Hospital Olomouc, Department of Obstetrics and Gynecology, University Hospital Olomouc.
  
  
  METHODS
  Between the years 2000-2011, a total of 45 435 pregnant women were examined at the Department of Transfusion Medicine at the University Hospital Olomouc. Screening for irregular anti-erythrocyte antibodies followed by identification of the alloantibody was performed in all women at the beginning of the pregnancy.
  
  
  RESULTS
  Clinically significant anti-erythrocyte antibodies were diagnosed in 1.5% pregnant women (683/45435). The most common cause of maternal alloimmunization was antigen E with an incidence of 5.7 (258/45435), followed by antigen D 4.0 (181/45435), M 1.5 (70/45435), C 1.2 (54/45435), K 1.2 (55/45435), c 0.6 (26/45435), S 0.4 (20/45435), Jka 0.2 (9/45435), PP1pk (Tja) 0.1 (3/45435) and antigen Fya 0.0 (2/45435).
  
  
  CONCLUSIONS
  Despite performing prophylaxis for RhD alloimmunization by administering anti-D immunoglobulin to RhD negative women during pregnancy and after the birth of an RhD positive child, antigen RhD still represents the 2nd most frequent cause of maternal erythrocyte alloimmunization. The remaining clinically significant alloimmunizations are caused by non-D antigens of the Rh system, antigens of the Kell system, and rarely observed antigens of the MNS and Kidd blood systems.
authors.affiliation: Transfuzní oddelní FN a LF UP, Olomouc.
authors.forename: I
authors.initials: I
authors.lastname: Holusková
authors.forename: M
authors.initials: M
authors.lastname: Lubušký
authors.forename: M
authors.initials: M
authors.lastname: Studničková
authors.forename: M
authors.initials: M
authors.lastname: Procházka
mesh_terms: D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First
chemical_list: D007518:Isoantibodies