title: A higher score on the dermatology life quality index, being on systemic treatment and having a diagnosis of psoriatic arthritis is associated with increased costs in patients with plaque psoriasis.
abstract: The aim of this study was to examine the relationship between measures of disease severity and costs from a societal perspective in patients with plaque psoriasis. Dermatologists in Sweden recruited 443 consecutive patients who had had no biological treatment during the past 12 months. Following a Psoriasis Area and Severity Index (PASI) assessment, subjects completed self-assessments on health status/quality of life and a healthcare resource utilization/work status questionnaire. The costs of healthcare resources and sick-leave due to plaque psoriasis were estimated and related to the subject's health status. A patient's Dermatology Life Quality Index (DLQI) and being on systemic therapy, or having diagnosis of psoriatic arthritis, appeared to be more strongly associated with direct and indirect costs than did their PASI. The cost of biological therapy should be considered from the perspective of the already high costs of patients with high DLQI undergoing traditional systemic treatment.
authors.affiliation: Department of Health Economics, Pfizer AB, 19190 Sollentuna, Sweden. mats.ekelund@pfizer.com.
authors.forename: Mats
authors.initials: M
authors.lastname: Ekelund
authors.forename: Lotus
authors.initials: L
authors.lastname: Mallbris
authors.forename: Susanne
authors.initials: S
authors.lastname: Qvitzau
authors.forename: Berndt
authors.initials: B
authors.lastname: Stenberg
mesh_terms: D000041:Absenteeism; D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000175:diagnosis* / Q000188:drug therapy / Q000191:economics* / Q000523:psychology; D017281:Cost of Illness; D003362:Cost-Benefit Analysis; D016527:Drug Costs; D005260:Female; D017048:Health Care Costs; D006295:Health Resources / Q000191:economics* / Q000706:statistics & numerical data; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011788:Quality of Life; D012189:Retrospective Studies; D012720:Severity of Illness Index; D018582:Sick Leave / Q000191:economics; D011795:Surveys and Questionnaires; D013548:Sweden; D016896:Treatment Outcome