title: Integrated chemo-enzymatic production of 5-hydroxymethylfurfural from glucose.
abstract: Sweets for my sweet: The production and isolation of 5-hydroxymethylfurfural (HMF) in high yield and purity is demonstrated by using a combination of glucose-fructose isomerization with sweetzyme in wet tetraethylammonium bromide (TEAB) and clean fructose dehydration to HMF catalyzed by using HNO₃ under moderate conditions, which allow the reuse of any unreacted glucose and TEAB.
authors.affiliation: Research Institute for Medicines and Pharmaceuticals Sciences, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-019, Portugal.
authors.forename: Svilen P
authors.initials: SP
authors.lastname: Simeonov
authors.forename: Jaime A S
authors.initials: JA
authors.lastname: Coelho
authors.forename: Carlos A M
authors.initials: CA
authors.lastname: Afonso
mesh_terms: D056804:Biofuels; D004798:Enzymes / Q000378:metabolism*; D005632:Fructose / Q000737:chemistry; D005662:Furaldehyde / Q000031:analogs & derivatives* / Q000737:chemistry; D005947:Glucose / Q000737:chemistry*; D007536:Isomerism
chemical_list: D056804:Biofuels; D004798:Enzymes; D005632:Fructose; C008046:5-hydroxymethylfurfural; D005662:Furaldehyde; D005947:Glucose