title: Platelet motion near a vessel wall or thrombus surface in two-dimensional whole blood simulations.
abstract: Computational simulations using a two-dimensional lattice-Boltzmann immersed boundary method were conducted to investigate the motion of platelets near a vessel wall and close to an intravascular thrombus. Physiological volume fractions of deformable red blood cells and rigid platelet-size elliptic particles were studied under arteriolar flow conditions. Tumbling of platelets in the red-blood-cell depleted zone near the vessel walls was strongly influenced by nearby red blood cells. The thickness of the red-blood-cell depleted zone was greatly reduced near a thrombus, and platelets in this zone were pushed close to the surface of the thrombus to distances that would facilitate their cohesion to it. The distance, nature, and duration of close platelet-thrombus encounters were influenced by the porosity of the thrombus. The strong influence on platelet-thrombus encounters of red-blood-cell motion and thrombus porosity must be taken into account to understand the dynamics of platelet attachment to a growing thrombus.
authors.affiliation: Department of Mathematics, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Tyler
authors.initials: T
authors.lastname: Skorczewski
authors.forename: Lindsay Crowl
authors.initials: LC
authors.lastname: Erickson
authors.forename: Aaron L
authors.initials: AL
authors.lastname: Fogelson
mesh_terms: D000818:Animals; D001158:Arteries / Q000502:physiology*; D001792:Blood Platelets / Q000473:pathology / Q000502:physiology*; D002465:Cell Movement; D006801:Humans; D008954:Models, Biological; D010974:Platelet Aggregation; D013927:Thrombosis / Q000097:blood*