title: Metachronous bilateral ovarian teratoma: a germ-line familial disorder and review of surgical management options.
abstract: BACKGROUND
  Germ cell tumors in females are uncommon, and bilateral metachronous ovarian teratoma is even exceptional, with sporadic cases described in the literature.
  
  
  METHODS
  We report on a girl in whom a metachronous ovarian teratoma occurred 6 years after the first. The simultaneous onset of germ-line anomalies in other members of the family supports the existence of genetic or environmental factors conferring susceptibility to germ cell lesions.
  
  
  CONCLUSIONS
  The case here illustrated reminds the issue of the appropriate follow-up of these patients and of their families.
authors.affiliation: Department of Paediatric Surgery, Paediatric Surgery Unit, University of Bologna, Bologna, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Gobbi
authors.forename: F
authors.initials: F
authors.lastname: Fascetti Leon
authors.forename: A
authors.initials: A
authors.lastname: Aquino
authors.forename: F
authors.initials: F
authors.lastname: Melchionda
authors.forename: M
authors.initials: M
authors.lastname: Lima
mesh_terms: D002648:Child; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D013724:Teratoma / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*
keywords: Bilateral ovarian teratoma; Familial germ-line tumor; Ovary-sparing surgery