title: Orlistat-induced bullous leukocytoclastic vasculitis.
abstract: Cutaneous leukocytoclastic vasculitis (LCV), also known as small-vessel vasculitis, is a process thought to be related to the presence of circulating immune complexes. Leukocytoclastic vasculitis is thought to be idiopathic in up to 50% of cases, but other common causes and associated disorders include certain medications, most frequently antibiotics; infections; collagen-vascular disease; paraproteinemias; and rarely neoplasia. We report a patient with cutaneous LCV induced by orlistat, a pancreatic lipase inhibitor that works as a weight-loss agent by decreasing the absorption of dietary fat.
authors.affiliation: Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908, USA.
authors.forename: Tamara
authors.initials: T
authors.lastname: Lazic
authors.forename: Margaret
authors.initials: M
authors.lastname: Fonder
authors.forename: Leslie
authors.initials: L
authors.lastname: Robinson-Bostom
authors.forename: Caroline S
authors.initials: CS
authors.lastname: Wilkel
authors.forename: Laura
authors.initials: L
authors.lastname: Della Torre
mesh_terms: D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007783:Lactones / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy; D000077403:Orlistat; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000473:pathology
chemical_list: D019440:Anti-Obesity Agents; D007783:Lactones; D000077403:Orlistat