title: Dietary sodium: a therapeutic target in the treatment of hypertension and CKD.
abstract: Interventional trials of dietary sodium reduction have demonstrated improvements in blood pressure, cardiovascular events, and chronic kidney disease (CKD). Furthermore, public health initiatives to reduce population sodium intake in Finland and Japan have shown similar benefit in blood pressure and stroke reduction. Recent follow-up data from large cohort trials that suggest increased mortality among individuals with lower urinary sodium excretion have generated controversy regarding the optimal sodium intake. This paper reviews the evidence for the reduction of dietary sodium to prevent and manage chronic diseases, including hypertension, cardiovascular disease, and CKD.
authors.affiliation: Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Sanghavi
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Vassalotti
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002908:Chronic Disease; D004039:Diet, Sodium-Restricted; D005387:Finland; D006801:Humans; D006973:Hypertension / Q000517:prevention & control*; D007564:Japan; D011634:Public Health; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000517:prevention & control*; D017673:Sodium Chloride, Dietary / Q000009:adverse effects*
chemical_list: D017673:Sodium Chloride, Dietary