title: Prospective study of the efficacy of breast magnetic resonance imaging and mammographic screening in survivors of Hodgkin lymphoma.
abstract: OBJECTIVE
  Current guidelines recommend breast magnetic resonance imaging (MRI) as an adjunct to mammography for breast cancer screening in female cancer survivors treated with chest irradiation at a young age, beginning 8 to 10 years after treatment. Prospective data evaluating its efficacy in female cancer survivors are lacking. This study sought to compare the sensitivity and specificity of breast MRI with those of mammography in women who received chest irradiation for Hodgkin lymphoma (HL).
  
  
  METHODS
  We enrolled 148 women treated with chest irradiation for HL at age ≤ 35 years who were > 8 years beyond treatment. Yearly breast MRI and mammogram were performed over a 3-year period. Sensitivity and specificity of the two screening modalities were compared.
  
  
  RESULTS
  With the screening, 63 biopsies were performed in 45 women; 18 (29%) showed a malignancy. All but one of the screen-detected malignancies were preinvasive or subcentimeter node-negative breast cancers. After excluding first-screen MRI and mammogram, mammogram sensitivity was 68% as compared with 67% for MRI (P = 1.0). Sensitivity increased to 94% using both screening modalities. The specificities of mammogram alone, MRI alone, and both were 93%, 94%, and 90%, respectively.
  
  
  CONCLUSIONS
  In contrast to women with genetic or familial risk, in HL survivors breast MRI was not more sensitive than mammogram for breast cancer detection. However, the two screening modalities complement each other in the detection of early cases of disease. Early diagnosis is particularly important in these patients, given the breast cancer treatment challenges in patients who have received prior cancer therapy.
authors.affiliation: Brigham and Women's Hospital, Boston, MA, USA. ang@lroc.harvard.edu
authors.forename: Andrea K
authors.initials: AK
authors.lastname: Ng
authors.forename: Judy E
authors.initials: JE
authors.lastname: Garber
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Diller
authors.forename: Robyn L
authors.initials: RL
authors.lastname: Birdwell
authors.forename: Yang
authors.initials: Y
authors.lastname: Feng
authors.forename: Donna S
authors.initials: DS
authors.lastname: Neuberg
authors.forename: Barbara
authors.initials: B
authors.lastname: Silver
authors.forename: David C
authors.initials: DC
authors.lastname: Fisher
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Marcus
authors.forename: Peter M
authors.initials: PM
authors.lastname: Mauch
mesh_terms: D000293:Adolescent; D000328:Adult; D001940:Breast / Q000473:pathology / Q000528:radiation effects; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000209:etiology; D002648:Child; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography / Q000379:methods*; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis*; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D017741:Survivors / Q000706:statistics & numerical data*; D013997:Time Factors; D055815:Young Adult