title: Angiotensin-converting enzyme gene polymorphisms and the risk of psoriasis: a meta-analysis.
abstract: BACKGROUND
  The gene coding for angiotensin-converting enzyme (ACE) has been reported to be associated with the development of psoriasis.
  
  
  OBJECTIVE
  To evaluate the association of psoriasis risk and ACE polymorphisms.
  
  
  METHODS
  We carried out a retrieval of studies that explored associations between ACE polymorphism and psoriasis, and analysed the genotype frequencies.
  
  
  RESULTS
  In total, 8 studies with 1242 patients and 1646 controls were included. The genotype frequencies in all studies were in Hardy-Weinberg equilibrium. After pooling all studies, the results indicated that the I/I genotype was associated with risk of psoriasis (OR = 1.41, 95% CI 1.11-1.80, P = 0.005), whereas the I/D genotype may decrease the risk of psoriasis (OR = 0.71, 95% CI 0.56-0.90, P = 0.005) in Asian, but not in white populations.
  
  
  CONCLUSIONS
  Our study suggests that ACE polymorphism are associated with the risk of psoriasis in Asians, especially the I/I genotype and I allele. Further studies are needed to confirm our results.
authors.affiliation: Department of Physiology, Kunming Medical University, Kunming, Yunnan, China.
authors.forename: T
authors.initials: T
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Han
authors.forename: L
authors.initials: L
authors.lastname: Lu
mesh_terms: D000818:Animals; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000235:genetics*
chemical_list: D007703:Peptidyl-Dipeptidase A