title: Bone mineral density in adolescents with eating disorders exposed to selective serotonin reuptake inhibitors.
abstract: Retrospective chart review was used to collect data from adolescents seen in a specialized eating disorder program over an 11-year period in order to investigate any association between exposure to selective serotonin reuptake inhibitors (SSRIs) and bone mineral density (BMD). SSRI users were matched with controls based on age (within 1.5 years), gender, eating disorder diagnosis, and percent ideal body weight (within 5%), resulting in a sample of 31 pairs. SSRI users had significantly lower BMD z-scores, compared to controls (-1.094 vs. -0.516, p < .035), suggesting that exposure to SSRIs may be a risk factor for lowered BMD.
authors.affiliation: Department of Psychiatry & Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada. coutur@mcmaster.ca
authors.forename: Jennifer
authors.initials: J
authors.lastname: Couturier
authors.forename: Alice
authors.initials: A
authors.lastname: Sy
authors.forename: Natasha
authors.initials: N
authors.lastname: Johnson
authors.forename: Sheri
authors.initials: S
authors.lastname: Findlay
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000928:Antidepressive Agents / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects*; D016022:Case-Control Studies; D001068:Feeding and Eating Disorders / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors