title: Gemcitabine and cisplatin-induced tumor lysis syndrome in a patient with gallbladder carcinoma: A case report.
abstract: We report a case of tumor lysis syndrome (TLS) in a patient with gallbladder carcinoma. TLS has not been reported in association with this type of tumor. TLS typically occurs in cases of highly proliferative hematological malignancies and small cell carcinoma. Two factors that may have contributed to TLS in this case include multifactorial mild acute renal failure shortly before the administration of chemotherapy and the aggressive morphology of the gallbladder carcinoma, which was a poorly differentiated sarcomatoid variant. This case raises concern for the development of TLS in certain types of patients with solid tumors.
authors.affiliation: Departments of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia;
authors.forename: Deiter J
authors.initials: DJ
authors.lastname: Duff
authors.forename: Shadi
authors.initials: S
authors.lastname: Haddadin
authors.forename: Carl
authors.initials: C
authors.lastname: Freter
authors.forename: Chris
authors.initials: C
authors.lastname: Papageorgiou
keywords: gallbladder carcinoma; gemcitabine; renal failure; solid tumors; tumor lysis syndrome