title: Ageing and Brugada syndrome: considerations and recommendations.
abstract: Brugada syndrome is an inherited disease associated with an increased risk of lethal ventricular arrhythmias. Such arrhythmias stem from innate disruptions in cardiac electrophysiology. Typically, such arrhythmias occur in the third or fourth decade of life. However, Brugada syndrome may also affect geriatric patients. In this paper, we focus on the ageing patient with Brugada syndrome, and specifically, on the interaction between Brugada syndrome and the more usually acquired clinical problems that may occur with increasing age, such as the use of cardiovascular and non-cardiovascular drugs, or the need for surgery. Such common conditions may also disrupt cardiac electrophysiology, thereby conferring added risk for Brugada syndrome patients. We present some considerations and recommendations that may serve as guidance to address these complexities.
authors.affiliation: Department of Cardiology, Heart Center, Academic Medical Center, University of Amsterdam, P.O. box 22660, 1100 DD Amsterdam, The Netherlands.
authors.forename: Pieter G
authors.initials: PG
authors.lastname: Postema
authors.forename: Hanno L
authors.initials: HL
authors.lastname: Tan
authors.forename: Arthur Am
authors.initials: AA
authors.lastname: Wilde
keywords: Aging; Arrhythmias; Brugada syndrome; Geriatrics; Risk stratification; Sudden death