title: Risk assessment of mouse gastric tissue cancer induced by dichlorvos and dimethoate.
abstract: Cancer hazards from pesticide residues in food have been much discussed in the past decade. In this study, we showed that dichlorvos and dimethoate affect hemoglobin content and hematocrit value, but had no effect on red blood cell counts and total plasma protein in mice. A 40-mg/kg/day dose of dichlorvos upregulated the expression ofp16,Bcl-2andc-mycgenes in mouse gastric tissue. By contrast, expression of thep16,Bcl-2andc-mycgenes induced by low doses (5, 10 and 20 mg/kg/day) of dichlorvos demonstrated no change in the control check group (CK; 200μl sterile saline perfused group; 0 mg/kg/day). Different doses of dimethoate all upregulated the expression ofp16,Bcl-2andc-mycgenes in mouse gastric tissue. The results further demonstrated that mouse gastric tissue, exposed in the long-term to low doses of dichlorvos and dimethoate, has the potential to become cancerous.
authors.affiliation: Key Laboratory of Biomedical Engineering and Technology of Shandong High School, Shandong Wanjie Medical College, Zibo 255213, P.R. China.
authors.forename: Qing-Lu
authors.initials: QL
authors.lastname: Wang
authors.forename: Yu-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Cai-Xia
authors.initials: CX
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Ye
authors.initials: Y
authors.lastname: Dou
authors.forename: Qiao-Qiao
authors.initials: QQ
authors.lastname: Li
keywords: dichlorvos; dimethoate; gastric cancer; mouse; transcription