title: Computed tomography imaging-guided radiotherapy by targeting upconversion nanocubes with significant imaging and radiosensitization enhancements.
abstract: The clinical potentials of radiotherapy could not be achieved completely because of the inaccurate positioning and inherent radioresistance of tumours. In this study, a novel active-targeting upconversion theranostic agent (arginine-glycine-aspartic acid-labelled BaYbF5: 2% Er(3+) nanocube) was developed for the first time to address these clinical demands. Heavy metal-based nanocubes (~10 nm) are potential theranostic agents with bifunctional features: computed tomography (CT) contrast agents for targeted tumour imaging and irradiation dose enhancers in tumours during radiotherapy. Remarkably, they showed low toxicity and excellent performance in active-targeting CT imaging and CT imaging-guided radiosensitizing therapy, which could greatly concentrate and enlarge the irradiation dose deposition in tumours to enhance therapeutic efficacy and minimize the damage to surrounding tissues.
authors.affiliation: State Key Laboratory of High performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Huaiyong
authors.initials: H
authors.lastname: Xing
authors.forename: Xiangpeng
authors.initials: X
authors.lastname: Zheng
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Ren
authors.forename: Wenbo
authors.initials: W
authors.lastname: Bu
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Ge
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Xiao
authors.forename: Shengjian
authors.initials: S
authors.lastname: Zhang
authors.forename: Chenyang
authors.initials: C
authors.lastname: Wei
authors.forename: Haiyun
authors.initials: H
authors.lastname: Qu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Hua
authors.forename: Liangping
authors.initials: L
authors.lastname: Zhou
authors.forename: Weijun
authors.initials: W
authors.lastname: Peng
authors.forename: Kuaile
authors.initials: K
authors.lastname: Zhao
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D019216:Metals, Heavy / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents / Q000737:chemistry*; D011878:Radiotherapy / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D019216:Metals, Heavy; D011838:Radiation-Sensitizing Agents