title: Changes in the MALT1-A20-NF-κB expression pattern may be related to T cell dysfunction in AML.
abstract: To elucidate the characteristics of T-cell receptor (TCR) signal transduction in T-cells from acute myeloid leukemia (AML), the mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1), A20, NF-κB and MALT1-V1 gene expression levels in CD3+ T cells sorted from the peripheral blood of patients with AML were analyzed by real-time PCR. A significantly lower MALT1 and A20 expression level was found in T cells from patients with AML compared with healthy controls (p = 0.045, p < 0.0001); however, the expression level of MALT1-V1 (variant 1) was significantly higher in the AML group than in the healthy control group (p = 0.006), and the expression level of NF-κB was increased in the AML group. In conclusion, the characteristics of the expression pattern of MALT1-A20-NF-κB and the distribution of MALT1 variants in T cells from AML were first characterized. Overall, low TCR-CD3 signaling is related to low MALT1 expression, which may related to T cell immunodeficiency, while the up-regulation of MALT1-V1 may play a role in overcoming the T cell activity by downregulating A20 in patients with AML, which may be related to a specific response to AML-associated antigens.
authors.affiliation: Institute of Hematology, Jinan University, Guangzhou, 510632, China. yangqiuli@hotmail.com.
authors.forename: Li
authors.initials: L
authors.lastname: Shi
authors.forename: Shaohua
authors.initials: S
authors.lastname: Chen
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Lu
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Lijian
authors.initials: L
authors.lastname: Yang
authors.forename: Xiuli
authors.initials: X
authors.lastname: Wu
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Yangqiu
authors.initials: Y
authors.lastname: Li