title: Expression of the PXR gene in various types of cancer and drug resistance.
abstract: Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors. PXR is a key xenobiotic receptor that regulates the expression of genes implicated in drug metabolism, detoxification and clearance, including drug metabolizing enzymes and transporters, suggesting that it is significant in the drug resistance of cancer cells. PXR is expressed in a wide range of tissues in the human body. Studies have demonstrated that PXR is expressed in a variety of tumor types, correlating not only with drug resistance but also with the cell proliferation, apoptosis and prognosis of cancer. The purpose of the present review is to provide a comprehensive review of PXR and its potential roles in multidrug resistance and the biological characteristics of PXR-positive tumors.
authors.affiliation: Department of General Surgery, Jiangsu Cancer Hospital, Affiliated to Nanjing Medical University, Nanjing 210009;
authors.forename: Enqi
authors.initials: E
authors.lastname: Qiao
authors.forename: Minghua
authors.initials: M
authors.lastname: Ji
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Wu
authors.forename: Rong
authors.initials: R
authors.lastname: Ma
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Zhang
authors.forename: Yuejun
authors.initials: Y
authors.lastname: He
authors.forename: Quanbin
authors.initials: Q
authors.lastname: Zha
authors.forename: Xue
authors.initials: X
authors.lastname: Song
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Zhu
authors.forename: Jinhai
authors.initials: J
authors.lastname: Tang
keywords: cancer; multidrug resistance; pregnane X receptor; tumor cell apoptosis