title: Therapeutic potency of Poly I:C in HSV-induced inflammation through up-regulation of IL-15 receptor alpha.
abstract: Interleukin-15 receptor alpha (IL-15Rα) forms stable complex with IL-15 on the cell surface of activated monocytes and mediates the proliferation of memory CD8+ T cells. Recent studies informed that polyinosinic:polycytidylic acid (Poly I:C) is an immunostimulant which boosts the generation of memory T cells through induction of IL-15Rα. The aim of this study is to evaluate the relevance of IL-15Rα in Herpes simplex virus (HSV)-induced Behçet's disease (BD) mouse model and BD patients. The frequencies of IL-15Rα expression in PBMCs of BD patients and BD-like symptomatic mice were analyzed by flow cytometry. In addition, Poly I:C supplementation could reduce inflammation through the up-regulation of memory T cells and IL-15Rα+ cells accompany with down-regulation of pro-inflammatory cytokine, IL-17A in BD mice. In BD patients, the frequencies of IL-15Rα expression in PBMCs were also significantly different between the inactive and active disease states. These results suggest that IL-15Rα is a relevant factor in BD.
authors.affiliation: Laboratory of Cell Biology, Institute for Medical Sciences, Ajou University, Suwon, Republic of Korea.
authors.forename: Juyoung
authors.initials: J
authors.lastname: Choi
authors.forename: Eun-So
authors.initials: ES
authors.lastname: Lee
authors.forename: Bunsoon
authors.initials: B
authors.lastname: Choi
authors.forename: Seonghyang
authors.initials: S
authors.lastname: Sohn
mesh_terms: D000818:Animals; D001528:Behcet Syndrome / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007156:Immunologic Memory / Q000187:drug effects; D007249:Inflammation / Q000276:immunology; D053720:Interleukin-15 Receptor alpha Subunit / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008875:Middle Aged; D011070:Poly I-C / Q000627:therapeutic use*; D018139:Simplexvirus / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D015854:Up-Regulation / Q000187:drug effects; D014775:Virus Activation / Q000235:genetics / Q000276:immunology
chemical_list: D053720:Interleukin-15 Receptor alpha Subunit; D020381:Interleukin-17; D011070:Poly I-C
keywords: Behçet's disease; Herpes simplex virus; IL-15Rα; Inflammation; Memory T cells; Mouse model; Poly I:C