title: Antibacterial evaluation of novel organoarsenic compounds by the microcalorimetric method.
abstract: Antibacterial activities of novel organoarsenic compounds As(III)-containing Schiff bases on Escherichia coli (CCTCCAB91112) were investigated by microcalorimetry in this study. The experimental result showed that the arsenic(III)-containing Schiff bases at micromolar concentration exhibit strong inhibition on the E. coli. Specifically, the growth rate constant k decreased, and the generation time t G and the inhibitory ratio I (percentage) increased with the increased dose of the arsenicals as inhibitors. All of the arsenicals display the feature of considerable lag phase inhibition on the cell growth. The compound 4-(4-bromobenzaliminyl)phenylarsenoxide makes the lag phase of E. coli cell growth cycles to reach 650 min at 5 μmol/L. The compounds with donating electron groups at aromatic ring B have lower IC50 to present higher antibacterial activity. The compound 4-(4-hydroxyl-3-methoxylbenzaliminyl)phenylarsenoxide has the lowest IC50 (1.82 μmol/L) to show the strongest antibacterial activity among them.
authors.affiliation: State Key Laboratory of Virology, College of Chemistry and Molecule Sciences, Wuhan University, 430072 Wuhan, People's Republic of China.
authors.forename: Xin-You
authors.initials: XY
authors.lastname: Chen
authors.forename: Xin-Liang
authors.initials: XL
authors.lastname: Hu
authors.forename: Cai-Fen
authors.initials: CF
authors.lastname: Xia
authors.forename: Cai-Qin
authors.initials: CQ
authors.lastname: Qin
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001152:Arsenicals / Q000494:pharmacology*; D002151:Calorimetry / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009930:Organic Chemicals / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001152:Arsenicals; D009930:Organic Chemicals