title: Relapsing polychondritis.
abstract: Relapsing polychondritis (RP) is a rare systemic autoimmune disease characterized by episodic, progressive inflammatory destruction of cartilage. It can occur as an overlap syndrome in patients with other rheumatologic conditions. The disease usually follows an indolent relapsing-remitting course, but occasionally it can progress rapidly and even cause death. Although auricular or nasal chondritis or peripheral arthritis without other significant organ involvement are usually treated with low-dose corticosteroids, other more severe disease manifestations may require treatment with high-dose corticosteroids or other immunosuppressive agents. Biological targeted therapies might prove to be effective treatments of this condition.
authors.affiliation: Rheumatology Center, Memorial Campus, UMass Memorial Medical Center, 119 Belmont Street, Worcester, MA 01605, USA.
authors.forename: Ratnesh
authors.initials: R
authors.lastname: Chopra
authors.forename: Nida
authors.initials: N
authors.lastname: Chaudhary
authors.forename: Jonathan
authors.initials: J
authors.lastname: Kay
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000453:epidemiology*; D015897:Comorbidity; D004425:Ear Cartilage / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D058990:Molecular Targeted Therapy; D009190:Myelodysplastic Syndromes / Q000453:epidemiology*; D011081:Polychondritis, Relapsing / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D025242:Spondylarthropathies / Q000453:epidemiology*; D014657:Vasculitis / Q000453:epidemiology*
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; C502936:tocilizumab