title: [Tear film and lacrimal excretion changes after lacrimal gland tumor removal].
abstract: OBJECTIVE
  To study the change of tear film and lacrimal secretion after lacrimal gland tumor removal operation.
  
  
  METHODS
  It was a retrospective case series study. Nineteen cases (19 eyes) with pleomorphic adenoma of the lacrimal gland from January, 2010 to July, 2011 in Eye and ENT Hospital of Fudan University were elected. The evaluation included subjective complaints of dry eye, tear break up time (BUT), reflex lacrimal secretion, corneal fluorescein staining, and size of lacrimal lake were analyzed before surgery and 3 days, 1 month and 6 months postoperatively. Simultaneously, the opposite eye was set as control.
  
  
  RESULTS
  Subjective complaints of dry eye increased and the mean tear break up time, reflex lacrimal secretion, and size of lacrimal lake were significantly reduced (t = 23.91, 16.90, 11.47; t = 19.31, 20.81, 11.95, P < 0.05) on day 3 and 1 month after operation which were (4.9 ± 2.0) s (3 d), (5.2 ± 1.6) s (1 moth); (4.05 ± 2.07) mm (3 d), (3.58 ± 1.98) mm (1 moth); (0.009 ± 0.004) mm(2) (3 d), (0.008 ± 0.003) mm(2)(1 moth) respectively. However, only reflex secretion test (3.53 ± 1.50 mm) was significantly reduced (t = 21.57, P < 0.05), other values (BUT: 17.4 ± 4.9 s, size of lake: 0.032 ± 0.005 mm(2)) recovered to preoperative levels by the time of the sixth month follow up visit. Corneal fluorescein staining score increased greatly when measured at day 3 and 1 month visit (t = 0.23, 1.69, P < 0.05), but had returned to preoperative values at the sixth month visit. The result of the opposite eye control is the same as preoperative control.
  
  
  CONCLUSIONS
  During the early stage after lacrimal gland tumor removal, tear film present abnormal changes, mainly in tear stability and reduction of reflex lacrimal secretion.
authors.affiliation: Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.
authors.forename: Yan-qing
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Jiang
authors.initials: J
authors.lastname: Qian
authors.forename: Yi-fei
authors.initials: YF
authors.lastname: Yuan
authors.forename: Kang
authors.initials: K
authors.lastname: Xue
authors.forename: Jie
authors.initials: J
authors.lastname: Guo
authors.forename: Xiang-ning
authors.initials: XN
authors.lastname: Wang
mesh_terms: D008949:Adenoma, Pleomorphic / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005134:Eye Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D007765:Lacrimal Apparatus / Q000378:metabolism* / Q000473:pathology; D007766:Lacrimal Apparatus Diseases / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012189:Retrospective Studies; D013666:Tears / Q000378:metabolism*; D055815:Young Adult