title: [Prior infected influenza virus could protect mice from challenge of lethal influenza virus].
abstract: OBJECTIVE
  To determine whether it could protect mice from challenge of lethal influenza virus which group prior infected A(H1N1) pdm09 and H9N2 virus respectively.
  
  
  METHODS
  150 BALB/c mice are divided into three groups. Mice are infected A(H1N1) pdm09 virus (pCA07) and poultry H9N2 virus (GZ333) respectively. Infected mice are challenged with 10 times of lethal dose virus (PR8) then compare the viral load, antibody and survival of the two group mice before and after challenged.
  
  
  RESULTS
  Both experimental group mice survived after challenge of lethal influenza virus and lung viral load are lower than that of the first infection. Antibodies derived from the infective virus and challenge virus.
  
  
  CONCLUSIONS
  Prior infected A(H1N1) pdm09 and H9N2 virus could protect mice from challenge of lethal influenza virus.
authors.affiliation: Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, China CDC, WHO Collaborating Center for Reference and Research on Influenza, 155 Changbai Road, Bejing 102206, China.
authors.forename: Li-Qi
authors.initials: LQ
authors.lastname: Liu
authors.forename: Zi
authors.initials: Z
authors.lastname: Li
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhu
authors.forename: Yue-Long
authors.initials: YL
authors.lastname: Shu
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000502:physiology*; D053127:Influenza A Virus, H9N2 Subtype / Q000502:physiology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control* / Q000821:virology*; D008168:Lung / Q000276:immunology / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D019562:Viral Load
chemical_list: D000914:Antibodies, Viral