title: Measurement of the uniaxial mechanical properties of healthy and atherosclerotic human coronary arteries.
abstract: Atherosclerosis is a common arterial disease which alters the stiffness of arterial wall. Arterial stiffness is related to many cardiovascular diseases. In this investigation, maximum stress and strain as well as physiological and maximum elastic modulus of 22 human coronary arteries are measured. In addition, the force-displacement diagram of human coronary artery is obtained to discern the alterations between the healthy and atherosclerotic arterial wall stiffness. The age of each specimen and its effect on the elastic modulus of human coronary arteries is also considered. Twenty-two human coronary arteries, including eight atherosclerotic and fourteen healthy arteries are excised within 5 hours post-mortem. Samples are mounted on a tensile-testing machine and force is applied until breakage occurs. Elastic modulus coefficient of each specimen is calculated to compare the stiffness of healthy and atherosclerotic coronary arteries. The results show that the atherosclerotic arteries bear 44.55% more stress and 34.61% less strain compared to the healthy ones. The physiological and maximum elastic moduli of healthy arteries are 2.53 and 2.91 times higher than that of atherosclerotic arteries, respectively. The age of specimens show no correlation with the arterial wall stiffness. A combination of biomechanics and mathematics is used to characterize the mechanical properties of human coronary arteries. These results could be utilized to understand the extension and rupture mechanism of coronary arteries and has implications for interventions and surgeries, including balloon-angioplasty, bypass, and stenting.
authors.affiliation: Tissue Engineering and Biomaterials Division, National Institute of Genetic Engineering and Biotechnology, Tehran 14965/161, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Karimi
authors.forename: Mahdi
authors.initials: M
authors.lastname: Navidbakhsh
authors.forename: Ahmad
authors.initials: A
authors.lastname: Shojaei
authors.forename: Shahab
authors.initials: S
authors.lastname: Faghihi
mesh_terms: D050197:Atherosclerosis / Q000503:physiopathology*; D003331:Coronary Vessels / Q000503:physiopathology*; D004548:Elasticity; D006801:Humans; D066298:In Vitro Techniques; D013718:Tensile Strength