title: Role of BNP levels on the prognosis of decompensated advanced heart failure.
abstract: BACKGROUND
  Heart failure (HF) is a condition with poor outcome, especially in advanced cases. Determination of B-type natriuretic peptide (BNP) levels is useful in the diagnosis of cardiac decompensation and has also been proving useful in the prognostic evaluation.
  
  
  OBJECTIVE
  To verify whether BNP levels are able to identify patients with a poorer outcome and whether it is an independent prognostic factor considering age, gender, cardiac and renal functions, as well as the cause of heart disease.
  
  
  METHODS
  189 patients in functional class III/IV advanced HF were studied. All had systolic dysfunction and had their BNP levels determined during hospitalization. Variables related to mortality were studied using univariate and multivariate analyses.
  
  
  RESULTS
  BNP levels were higher in patients who died in the first year of follow-up (1,861.9 versus 1,408.1 pg/dL; p = 0.044) and in chagasic patients (1,985 versus 1,452 pg/mL; p = 0.001); the latter had a higher mortality rate in the first year of follow-up (56% versus 35%; p = 0.010). The ROC curve analysis showed that the BNP level of 1,400 pg/mL was the best predictor of events; high levels were associated with lower LVEF (0.23 versus 0.28; p = 0.002) and more severe degree of renal dysfunction (mean urea 92 versus 74.5 mg/dL; p = 0.002).
  
  
  CONCLUSIONS
  In advanced HF, high BNP levels identified patients at higher risk of a poorer outcome. Chagasic patients showed higher BNP levels than those with heart diseases of other causes, and have poorer prognosis.
authors.affiliation: Instituto do Coração, FMUSP, São Paulo, SP, Brazil. pbarreto@cardiol.br
authors.forename: Antônio Carlos
authors.initials: AC
authors.lastname: Pereira-Barretto
authors.forename: Carlos Henrique Del
authors.initials: CH
authors.lastname: Carlo
authors.forename: Juliano Novaes
authors.initials: JN
authors.lastname: Cardoso
authors.forename: Marcelo Eid
authors.initials: ME
authors.lastname: Ochiai
authors.forename: Marcelo Villaça
authors.initials: MV
authors.lastname: Lima
authors.forename: Milena Cardoso
authors.initials: MC
authors.lastname: Curiati
authors.forename: Airton Roberto
authors.initials: AR
authors.lastname: Scipioni
authors.forename: José Antônio Franchini
authors.initials: JA
authors.lastname: Ramires
mesh_terms: D015415:Biomarkers / Q000097:blood; D002598:Chagas Cardiomyopathy / Q000097:blood* / Q000401:mortality; D004812:Epidemiologic Methods; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011379:Prognosis; D013318:Stroke Volume / Q000502:physiology; D014508:Urea / Q000097:blood
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; D014508:Urea