title: On your mark, get SET(D2), go! H3K36me3 primes DNA mismatch repair.
abstract: Trimethylation of histone H3 on Lys36 (H3K36me3) by SETD2 is linked to actively transcribed regions. Li et al. identify a novel role for H3K36me3 that facilitates DNA mismatch repair (MMR) in cells by targeting the MMR machinery to chromatin during the cell cycle, thereby explaining certain cases of MMR-defective cancers.
authors.affiliation: The Gurdon Institute and the Department of Biochemistry, University of Cambridge, Cambridge, UK.
authors.forename: Christine K
authors.initials: CK
authors.lastname: Schmidt
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Jackson