title: Update on body composition and bone density in children with Prader-Willi syndrome.
abstract: OBJECTIVE
  To compare body composition in children with Prader-Willi syndrome (PWS) not naïve to growth hormone (GH) with obese and lean controls.
  
  
  METHODS
  Participants included 12 children with PWS, 12 children with obesity (body fat percentage >95th percentile for age and sex) and 12 lean children (body fat percentage <85th percentile for age and sex) matched by age and height. Fat mass, lean mass, bone mineral content (BMC), bone mineral density (BMD) and BMD z-score for total body, hips and lumbar spine were obtained through dual X-ray absorptiometry.
  
  
  RESULTS
  PWS had higher fat percentage in the legs (p = 0.04) but similar leg fat mass (p = 1.00) compared to obese. PWS exhibited lower lean mass in the body (p = 0.04) and legs (p = 0.02) than obese, but similar to lean (p = 1.00 and p = 0.89, respectively). PWS had lower hip BMC (p < 0.01), BMD (p < 0.01) and BMD z-score (p < 0.01) compared to obese but similar to lean. No other differences were found between PWS and obese (p > 0.05 for all).
  
  
  CONCLUSIONS
  Children with PWS not naïve to GH present differences in fat and lean mass distribution compared to obese controls. BMC and BMD appear unaffected by PWS, except at the hips.
authors.affiliation: Department of Kinesiology, California State University, Fullerton, Calif. 92834, USA. drubin@fullerton.edu
authors.forename: Daniela A
authors.initials: DA
authors.lastname: Rubin
authors.forename: Natalia
authors.initials: N
authors.lastname: Cano-Sokoloff
authors.forename: Diobel L
authors.initials: DL
authors.lastname: Castner
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Judelson
authors.forename: Pamela
authors.initials: P
authors.lastname: Wright
authors.forename: Andrea
authors.initials: A
authors.lastname: Duran
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Haqq
mesh_terms: D015502:Absorptiometry, Photon; D050218:Body Fat Distribution; D015519:Bone Density; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D011218:Prader-Willi Syndrome / Q000473:pathology / Q000503:physiopathology