title: New trifluoromethyl quinolone derivatives: synthesis and investigation of antimicrobial properties.
abstract: A series of quinolone derivatives, containing different heterocyclic amines were prepared. Synthesized compounds were evaluated for their in vitro antimicrobial activities against two Gram-positive bacteria, three Gram-negative bacteria as well as four fungi. All the derivatives showed good activity towards Gram-positive bacteria and less activity towards Gram-negative bacteria. They also showed moderate to comparable activity against Aspergillus niger and Candida albicans and low to moderate antifungal activity against Aspergillus fumigatus and Aspergillus flavus.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110 007, India. sspanda12@gmail.com
authors.forename: Siva S
authors.initials: SS
authors.lastname: Panda
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Jain
mesh_terms: D000588:Amines / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001231:Aspergillus flavus / Q000187:drug effects; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005461:Fluorine / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000588:Amines; D000890:Anti-Infective Agents; D015363:Quinolones; D005461:Fluorine