title: The absolute configuration of (+)- and (-)-erythro-mefloquine.
abstract: The controversy over the absolute configuration of (+)-erythro-mefloquine, the less psychosis-causing enantiomer of the anti-malarial drug Lariam, has been resolved by Mosher ester crystallization. The configuration determined previously by physical methods is correct, whereas the configuration determined by three enantioselective syntheses is wrong.
authors.affiliation: Max-Planck-Institut für Biophysikalische Chemie, Department of NMR-Based Structural Biology, Am Fassberg 11, 37077 Göttingen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Müller
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Orben
authors.forename: Nina
authors.initials: N
authors.lastname: Schützenmeister
authors.forename: Manuel
authors.initials: M
authors.lastname: Schmidt
authors.forename: Andrei
authors.initials: A
authors.lastname: Leonov
authors.forename: Uwe M
authors.initials: UM
authors.lastname: Reinscheid
authors.forename: Birger
authors.initials: B
authors.lastname: Dittrich
authors.forename: Christian
authors.initials: C
authors.lastname: Griesinger
mesh_terms: D000962:Antimalarials / Q000737:chemistry*; D004917:Erythromycin / Q000737:chemistry*; D015767:Mefloquine / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000962:Antimalarials; D004917:Erythromycin; D015767:Mefloquine