title: Resting-state connectivity deficits associated with impaired inhibitory control in non-treatment-seeking adolescents with psychotic symptoms.
abstract: OBJECTIVE
  Psychotic symptoms are common in the population and index risk for a range of severe psychopathological outcomes. We wished to investigate functional connectivity in a community sample of adolescents who reported psychotic symptoms (the extended psychosis phenotype).
  
  
  METHODS
  This study investigated intrinsic functional connectivity (iFC) during resting-state functional magnetic resonance imaging (fMRI; rs-fMRI). Following screening in schools, 11 non-treatment seeking, youth with psychotic symptoms (aged 11-13) and 14 community controls participated in the study. Seed regions of interest comprised brain regions previously shown to exhibit aberrant activation during inhibitory control in adolescents with psychotic symptoms.
  
  
  RESULTS
  Relative to controls, adolescents with psychotic symptoms exhibited reduced iFC between regions supporting inhibitory control. Specifically, they showed weaker iFC between the right inferior frontal gyrus (IFG) and the cingulate, IFG and the striatum, anterior cingulate and claustrum, and precuneus and supramarginal gyrus. Conversely, the psychotic symptoms group exhibited stronger iFC between the superior frontal gyrus and claustrum and IFG and lingual gyrus.
  
  
  CONCLUSIONS
  The present findings are the first to reveal aberrant functional connectivity in resting-state networks in a community sample of adolescents with psychotic symptoms and suggest that disruption in integration between distributed neural networks (particularly between prefrontal, cingulate and striatal brain regions) may be a key neurobiological feature of the extended psychosis phenotype.
authors.affiliation: School of Psychology, Trinity College Dublin, Dublin, Ireland; Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Jacobson McEwen
authors.forename: C G
authors.initials: CG
authors.lastname: Connolly
authors.forename: A M C
authors.initials: AM
authors.lastname: Kelly
authors.forename: I
authors.initials: I
authors.lastname: Kelleher
authors.forename: E
authors.initials: E
authors.lastname: O'Hanlon
authors.forename: M
authors.initials: M
authors.lastname: Clarke
authors.forename: M
authors.initials: M
authors.lastname: Blanchard
authors.forename: S
authors.initials: S
authors.lastname: McNamara
authors.forename: D
authors.initials: D
authors.lastname: Connor
authors.forename: E
authors.initials: E
authors.lastname: Sheehan
authors.forename: G
authors.initials: G
authors.lastname: Donohoe
authors.forename: M
authors.initials: M
authors.lastname: Cannon
authors.forename: H
authors.initials: H
authors.lastname: Garavan
mesh_terms: D000293:Adolescent; D001479:Basal Ganglia / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D059907:Functional Neuroimaging; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D017072:Neostriatum / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology*; D011618:Psychotic Disorders / Q000503:physiopathology* / Q000523:psychology
keywords: functional magnetic resonance imaging; intrinsic functional connectivity; psychosis; psychotic symptoms; resting-state