title: Evaluating the male and female reproductive toxicity of high-boiling petroleum substances.
abstract: To meet the EPA HPV Chemical Challenge Program requirement for reproductive toxicity data on sponsored high-boiling petroleum substances (HBPS), an analysis was conducted using the results of 39 repeat-dose and 59 developmental rat dermal toxicity studies on HBPS samples spanning the boiling range of the sponsored substances, and the results of three one-generation reproductive toxicity studies on two samples spanning the concentration range of polycyclic aromatic compounds of sponsored substances. The analysis found little evidence of male or female reproductive tract toxicity based on histopathology, reproductive organ weight, and sperm parameters, and no evidence of effects on fertility, while significant developmental toxicity and/or systemic repeat-dose toxicity were frequently observed. Among 14 samples of HBPS tested in both repeat-dose toxicity and developmental toxicity studies, there were no studies in which an adverse reproductive tract finding occurred at a dose lower than that producing developmental toxicity or other adverse effects in repeat-dose toxicity studies. The current analysis supports the hypothesis that effects in developmental and/or repeat-dose toxicity studies of HBPS occur at doses lower than those that might affect fertility in rat one-generation reproductive studies. When adequate developmental and repeat-dose toxicity studies are available, a reproductive toxicity study of HBPS appears unnecessary.
authors.affiliation: Murray & Associates, 5529 Perugia Circle, San Jose, CA 95138, USA. Electronic address: jmurray2@sbcglobal.net.
authors.forename: F Jay
authors.initials: FJ
authors.lastname: Murray
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Gray
authors.forename: Linda G
authors.initials: LG
authors.lastname: Roberts
authors.forename: Randy N
authors.initials: RN
authors.lastname: Roth
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Nicolich
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Simpson
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D010578:Petroleum / Q000633:toxicity*; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects*; D044366:Transition Temperature
chemical_list: D010578:Petroleum; D011084:Polycyclic Aromatic Hydrocarbons
keywords: Fertility; HPV Chemical Challenge Program; High-boiling petroleum substances; Petroleum; Rat; Reproductive toxicity; Sperm; UVCB