title: Beneficial effects of Anadenanthera colubrina (Vell.) Brenan extract on the inflammatory and nociceptive responses in rodent models.
abstract: BACKGROUND
  Anadenanthera colubrina (Vell.) Brenan, popularly known as "angico", is a plant that has been widely used in folk medicine due to its anti-inflammatory property. To evaluate the pharmacological activities of this plant, studies were performed on its antinociceptive and anti-inflammatory properties.
  
  
  METHODS
  The AE of Anadenanthera colubrina, made from the bark, was used in rodents via oral route (p.o.), at 100, 200, and 400mg/kg in classical models of nociception (acetic acid-induced writhing and hot-plate test) and inflammation evoked by carrageenan (e.g., paw edema, peritonitis, and synovitis).
  
  
  RESULTS
  The acetic acid-induced abdominal writhes in mice were significantly reduced (P<0.001) by oral treatment with the extract (100, 200, and 400mg/kg), but the extract did not significantly increase the latency in the nociceptive hot-plate test. Anadenanthera colubrina aqueous extract reduced significantly the edema and, besides, diminished the mieloperoxidase activity (200 and 400mg/kg, P<0.01). The carrageenan-induced peritonitis was significantly reduced (P<0.05) by the aqueous extract at 100, 200, and 400mg/kg. The aqueous extract (200mg/kg) reduces the synovial leukocyte infiltration on carrageenan-induced synovitis in rats (P<0.01), but failed to significantly affect joint swelling and impaired mobility.
  
  
  CONCLUSIONS
  We show for the first time that the anti-inflammatory and peripheral antinociceptive activities of Anadenanthera colubrina are consistent, at least in part, with the use of this plant in popular medicine practices.
authors.affiliation: Pharmacology of Inflammation and Pain Laboratory, Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil.
authors.forename: Jandson S
authors.initials: JS
authors.lastname: Santos
authors.forename: Renata R
authors.initials: RR
authors.lastname: Marinho
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ekundi-Valentim
authors.forename: Leandro
authors.initials: L
authors.lastname: Rodrigues
authors.forename: Marcelo H
authors.initials: MH
authors.lastname: Yamamoto
authors.forename: Simone A
authors.initials: SA
authors.lastname: Teixeira
authors.forename: Marcelo N
authors.initials: MN
authors.lastname: Muscara
authors.forename: Soraia K
authors.initials: SK
authors.lastname: Costa
authors.forename: Sara M
authors.initials: SM
authors.lastname: Thomazzi
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007887:Fabaceae; D006358:Hot Temperature; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D010538:Peritonitis / Q000139:chemically induced / Q000188:drug therapy; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013585:Synovitis / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan; D019342:Acetic Acid