title: A common polymorphism of the MCT1 gene and athletic performance.
abstract: OBJECTIVE
  In red skeletal muscle, monocarboxylate transporter 1 (MCT1) is required for lactate to enter the myocytes for oxidation. The A1470T polymorphism (rs1049434) in the MCT1 gene was shown to be associated with lactate transport rates in human skeletal muscles. The aim of the study was to compare genotype and allele frequencies of the MCT1 gene polymorphism in 323 Russian athletes and 467 nonathletic controls and to investigate the association of the MCT1 gene A1470T polymorphism with maximal oxygen consumption and maximal lactate concentration in rowers (n = 79).
  
  
  METHODS
  Genotyping for the A1470T MCT1 polymorphism was performed by PCR-RFLP method. Physiological measurements of 79 Russian rowers of national competitive standard were determined during an incremental test to exhaustion on a rowing ergometer.
  
  
  RESULTS
  Frequencies of the A allele (71.8% vs 62.5%, P < .0001) and AA genotype (59.8% vs 39.4%, P < .0001) were significantly higher in endurance-oriented athletes (n = 142) than in the control group. Mean blood lactate concentration was higher in male rowers with the T allele (AT+TT 10.26 ± 1.89 mmol/L, AA 8.75 ± 1.69 mmol/L, P = .005).
  
  
  CONCLUSIONS
  MCT1 gene A1470T polymorphism is associated with endurance athlete status and blood lactate level after intensive exercise.
authors.affiliation: Sports Genetics Laboratory, St Petersburg Research Inst of Physical Culture, St Petersburg, Russia.
authors.forename: Olga N
authors.initials: ON
authors.lastname: Fedotovskaya
authors.forename: Leysan J
authors.initials: LJ
authors.lastname: Mustafina
authors.forename: Daniil V
authors.initials: DV
authors.lastname: Popov
authors.forename: Olga L
authors.initials: OL
authors.lastname: Vinogradova
authors.forename: Ildus I
authors.initials: II
authors.lastname: Ahmetov
mesh_terms: D000328:Adult; D054874:Athletic Performance; D016022:Case-Control Studies; D005080:Exercise Test; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D027501:Monocarboxylic Acid Transporters / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D027981:Symporters / Q000235:genetics*; D000099233:Monocarboxylate Transport Protein 1
chemical_list: D019344:Lactic Acid; D027501:Monocarboxylic Acid Transporters; D027981:Symporters; D000099233:Monocarboxylate Transport Protein 1