title: Mid-term evaluation of the new Glaukos iStent with phacoemulsification in coexistent open-angle glaucoma or ocular hypertension and cataract.
abstract: OBJECTIVE
  To evaluate the mid-term efficacy and safety of the GTS-400-iStent combined with phacoemulsification in patients with cataract and open-angle glaucoma (OAG) or ocular hypertension (OHT).
  
  
  METHODS
  Prospective, non-comparative, uncontrolled, interventional case series study. Subjects underwent phacoemulsification and two GTS-400 implantation. Efficacy outcomes: intraocular pressure (IOP) and antiglaucoma medications. Safety outcomes: complications, best-corrected visual acuity and endothelial cell count (ECC). Follow-up was 1 year.
  
  
  RESULTS
  20 patients were enrolled (mean age: 75.1 ± 8.6 years). Mean medicated baseline IOP was 19.95 ± 3.71 mm Hg and 26 ± 3.11 mm Hg without medication. Mean final IOP was 16.75 ± 2.24, determining a final IOP decrease of 35.68% (9.42 ± 3 mm Hg; p<0.001), from baseline washout IOP. Mean number of medications fell from 1.3 ± 0.66 to 0.3 ± 0.57 (P<0.001). 75% of patients were off medications at one year. Mean ECC decreased from 2289.64 ± 393.5 cells/mm(2) to 1986.95 ± 520.58 cells/mm(2).
  
  
  CONCLUSIONS
  Combined cataract surgery with implantation of GTS-400-iStent seems to be an effective and safe procedure.
authors.affiliation: Servicio de Oftalmología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), , Madrid, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Arriola-Villalobos
authors.forename: José Maria
authors.initials: JM
authors.lastname: Martínez-de-la-Casa
authors.forename: David
authors.initials: D
authors.lastname: Díaz-Valle
authors.forename: Sara E
authors.initials: SE
authors.lastname: García-Vidal
authors.forename: Cristina
authors.initials: C
authors.lastname: Fernández-Pérez
authors.forename: Julián
authors.initials: J
authors.lastname: García-Sánchez
authors.forename: Julián
authors.initials: J
authors.lastname: García-Feijoó
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage; D002386:Cataract / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D020327:Glaucoma Drainage Implants; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D018918:Phacoemulsification; D011446:Prospective Studies; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000959:Antihypertensive Agents
keywords: Aqueous humour; Glaucoma; Treatment Surgery