title: Probing functional tyrosines.
abstract: Reactivity probes are small molecules that contain a reactive electrophile and a purification handle, and are used to identify hyperreactive amino acid residues within a whole proteome. In this issue of Chemistry & Biology, Gu et al. use sulfonyl fluoride derivatives for the identification of functional tyrosine residues in different classes of glutathione S-transferases.
authors.affiliation: Lehrstuhl für Chemie der Biopolymere, Technische Universität München, Weihenstephaner Berg 3, 85354 Freising, Germany. verhelst@wzw.tum.de
authors.forename: Steven H L
authors.initials: SH
authors.lastname: Verhelst