title: Decision-making impairments in patients with Wilson's disease.
abstract: Wilson's disease (WD) causes deposition of copper, mainly in the basal ganglia. One consequence of deposition seems to be impairment of executive functions, which could cause problems in decision making. In 30 WD patients and 30 healthy controls (HCs), we examined decision making under risk in the Game of Dice Task, and we assessed working memory and executive functions. WD patients exhibited a greater preference for disadvantageous choices than did HCs. Reduced decision-making performance was closely correlated to lower executive functions. Decision-making deficits of WD might be associated with frontostriatal loops, which are involved in executive functions and feedback processing.
authors.affiliation: Neuropsychology Laboratory, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Ma
authors.forename: Xinyi
authors.initials: X
authors.lastname: Lv
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Han
authors.forename: Fangfang
authors.initials: F
authors.lastname: Zhang
authors.forename: Rong
authors.initials: R
authors.lastname: Ye
authors.forename: Fengqiong
authors.initials: F
authors.lastname: Yu
authors.forename: Yongzhu
authors.initials: Y
authors.lastname: Han
authors.forename: Johannes
authors.initials: J
authors.lastname: Schiebener
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
mesh_terms: D003657:Decision Making / Q000502:physiology*; D056344:Executive Function / Q000502:physiology; D030141:Feedback, Psychological; D005260:Female; D005715:Gambling / Q000523:psychology; D006527:Hepatolenticular Degeneration / Q000523:psychology*; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D055815:Young Adult