title: 2010 McDonald criteria in a pediatric cohort: is positivity at onset associated with a more aggressive multiple sclerosis course?
abstract: The 2010 McDonald criteria allow the diagnosis of multiple sclerosis (MS) at first attack in children and adults provided that the first attack symptoms are typical of MS and that the magnetic resonance imaging (MRI) conforms to prescribed features. We evaluate whether meeting the 2010 McDonald criteria at onset correlates with a more aggressive clinical course in a cohort of pediatric MS patients. The Expanded Disability Status Scale (EDSS) and annualized relapse rate were not associated with positivity for 2010 McDonald criteria at onset. The 2010 McDonald criteria identify children with similar MS features to those identified by clinical or MRI evidence of dissemination over time.
authors.affiliation: The Hospital for Sick Children, University of Toronto, Canada. Sandra.Bigi@sickkids.ca
authors.forename: Sandra
authors.initials: S
authors.lastname: Bigi
authors.forename: Ruth A
authors.initials: RA
authors.lastname: Marrie
authors.forename: Leonard
authors.initials: L
authors.lastname: Verhey
authors.forename: E Ann
authors.initials: EA
authors.lastname: Yeh
authors.forename: Brenda
authors.initials: B
authors.lastname: Banwell
mesh_terms: D017668:Age of Onset; D002490:Central Nervous System / Q000473:pathology*; D002648:Child; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000473:pathology*
keywords: Expanded Disability Status Scale; McDonald criteria; annualized relapse rate; magnetic resonance imaging; multiple sclerosis; pediatric