title: Microwave-assisted synthesis of new selenazole derivatives with antiproliferative activity.
abstract: New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with α-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtained under irradiation conditions. The structures of the synthesized compounds were assigned based on spectroscopic data (FT-IR, ¹H-NMR), MS and elemental analysis. Selenazole derivatives were screened for their anti-proliferative effects against two leukemia cell lines (CCRF-CEM and HL60) and three carcinoma cell lines (MDA-MB231, HCT116 and U87MG).
authors.affiliation: Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, RO-400012, Victor Babes 41, Cluj-Napoca, Romania. adriana.ignat@umfcluj.ro
authors.forename: Adriana Ignat
authors.initials: AI
authors.lastname: Ignat Grozav
authors.forename: Luiza
authors.initials: L
authors.lastname: Gaina
authors.forename: Victor
authors.initials: V
authors.lastname: Kuete
authors.forename: Luminita
authors.initials: L
authors.lastname: Silaghi-Dumitrescu
authors.forename: Thomas
authors.initials: T
authors.lastname: Efferth
authors.forename: Valentin
authors.initials: V
authors.lastname: Zaharia
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D001393:Azoles / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D045325:HCT116 Cells; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008872:Microwaves; D016566:Organoselenium Compounds / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D001393:Azoles; D016566:Organoselenium Compounds