title: Pathogenic Yersinia DNA in intestinal specimens of pediatric patients with Crohn's disease.
abstract: Studies indicate a close relationship between Yersinia and Crohn's disease in adults. Our study tested 77 colonic specimens from children with Crohn's disease for the presence of Yersinia DNA using a validated polymerase chain reaction (PCR) assay. Control cases included specimens from 45 ulcerative colitis patients and 10 appendicitis patients. The presence of Yersinia in Crohn's specimens was significant compared to the control specimens (9% vs. 0%; p = 0.0055). While our study supports the medical literature, future studies are needed to determine if the relationship between Crohn's disease and Yersinia is an initiating or mediating factor in the pathogenesis of pediatric Crohn's disease.
authors.affiliation: Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Sarah B
authors.initials: SB
authors.lastname: Leu
authors.forename: Sarah Catherine
authors.initials: SC
authors.lastname: Shulman
authors.forename: Charlotte Katherine
authors.initials: CK
authors.lastname: Steelman
authors.forename: Laura W
authors.initials: LW
authors.lastname: Lamps
authors.forename: Ozlem P
authors.initials: OP
authors.lastname: Bulut
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Abramowsky
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Gold
authors.forename: Sarah
authors.initials: S
authors.lastname: Szlam
authors.forename: Christina
authors.initials: C
authors.lastname: Stockwell
authors.forename: Jennifer
authors.initials: J
authors.lastname: Havens
authors.forename: Soha
authors.initials: S
authors.lastname: Kolta
authors.forename: Bahig M
authors.initials: BM
authors.lastname: Shehata
mesh_terms: D000293:Adolescent; D001426:Bacterial Proteins / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D003424:Crohn Disease / Q000382:microbiology*; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005798:Genes, Bacterial; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology; D008297:Male; D012189:Retrospective Studies; D015007:Yersinia / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity*; D015008:Yersinia enterocolitica / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D015011:Yersinia pseudotuberculosis / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D055815:Young Adult
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; C109227:YopP protein, Yersinia