title: Classical and unconventional pathways of vesicular release in microglia.
abstract: Emerging evidence indicates that activation of microglia, the immune cells of the brain, is strictly associated to both secretion of soluble molecules and release of extracellular membrane vesicles (EMVs) into the pericellular space. Through these processes, microglia heavily influence brain cell functions, either propagating inflammation and causing damage to neurons or playing a supportive, neuroprotective role. In this review, we highlight the emerging concepts related to vesicular mechanisms of secretion operating in microglial cells, with the aim of dissecting how microglia communicate with other cell types within the brain microenvironment in health and disease.
authors.affiliation: Humanitas Clinical and Research Center, Rozzano (MI), Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Prada
authors.forename: Roberto
authors.initials: R
authors.lastname: Furlan
authors.forename: Michela
authors.initials: M
authors.lastname: Matteoli
authors.forename: Claudia
authors.initials: C
authors.lastname: Verderio
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology* / Q000276:immunology; D055252:Cell-Derived Microparticles / Q000276:immunology / Q000378:metabolism*; D022162:Cytoplasmic Vesicles / Q000502:physiology*; D053583:Interleukin-1beta / Q000378:metabolism; D017628:Microglia / Q000166:cytology*; D055571:Secretory Pathway / Q000502:physiology*
chemical_list: D053583:Interleukin-1beta