title: Which part of the Quick mild cognitive impairment screen (Qmci) discriminates between normal cognition, mild cognitive impairment and dementia?
abstract: BACKGROUND
  the Qmci is a sensitive and specific test to differentiate between normal cognition (NC), mild cognitive impairment (MCI) and dementia. We compared the sensitivity and specificity of the subtests of the Qmci to determine which best discriminated NC, MCI and dementia.
  
  
  OBJECTIVE
  the objective was to determine the contribution each subtest of the Qmci makes, to its sensitivity and specificity in differentiating MCI from NC and dementia, to refine and shorten the instrument.
  
  
  METHODS
  existing data from our previous study of 965 subjects, testing the Qmci, was analysed to compare the sensitivity and specificity of the Qmci subtests.
  
  
  RESULTS
  all the subtests of the Qmci differentiated MCI from NC. Logical memory (LM) performed the best (area under the receiver operating curve of 0.80), registration the worst, (0.56). LM and verbal fluency had the largest median differences (expressed as percentage of total score) between MCI and NC, 20 and 25%, respectively. Other subtests did not have clinically useful differences. LM was best at differentiating MCI from NC, irrespective of age or educational status.
  
  
  CONCLUSIONS
  the Qmci incorporates several important cognitive domains making it useful across the spectrum of cognitive impairment. LM is the best performing subtest for differentiating MCI from NC.
authors.affiliation: Centre for Gerontology and Rehabilitation, St Finbarrs Hospital, Douglas Road, Cork City, Ireland. rocaoimh@hotmail.com
authors.forename: Rónán
authors.initials: R
authors.lastname: O'Caoimh
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.forename: Paul Francis
authors.initials: PF
authors.lastname: Gallagher
authors.forename: Joesph
authors.initials: J
authors.lastname: Eustace
authors.forename: Ciara
authors.initials: C
authors.lastname: McGlade
authors.forename: D William
authors.initials: DW
authors.lastname: Molloy
mesh_terms: D000368:Aged; D019540:Area Under Curve; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003071:Cognition; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000523:psychology; D003704:Dementia / Q000175:diagnosis* / Q000523:psychology; D003937:Diagnosis, Differential; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011597:Psychomotor Performance; D012372:ROC Curve