title: Prognostic value of HOXB7 mRNA expression in human oesophageal squamous cell cancer.
abstract: OBJECTIVE
  This study was to determine the role of HOXB7 in predicting outcomes of patients with oesophageal squamous cell cancer (OSCC).
  
  
  METHODS
  Samples were collected from 179 OSCC patients. HOXB7 mRNA expression was measured by quantitative real-time polymerase chain reaction.
  
  
  RESULTS
  HOXB7 mRNA expression was up-regulated in 85.1% of OSCC tumorous tissues, and correlated with age, pathological T and N category, as well as cancer-specific survival (CSS). However, subgroup analysis revealed its discernibility on CSS was only pronounced in early stage.
  
  
  CONCLUSIONS
  HOXB7 mRNA expression might serve as a novel prognostic biomarker for resected OSCC patients in early stage.
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, People's Republic of China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Xie
authors.forename: Shui-shen
authors.initials: SS
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Wen
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Kong-jia
authors.initials: KJ
authors.lastname: Luo
authors.forename: Fu
authors.initials: F
authors.lastname: Yang
authors.forename: Yi
authors.initials: Y
authors.lastname: Hu
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Fu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics*; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D015854:Up-Regulation
chemical_list: C490538:HOXB7 protein, human; D018398:Homeodomain Proteins; D012333:RNA, Messenger