title: Changes in renal function during acute spinal cord injury: implications for pharmacotherapy.
abstract: METHODS
  Laboratory investigation in rats submitted to experimental spinal cord injury (SCI).
  
  
  OBJECTIVE
  To characterize changes in renal function during acute SCI.
  
  
  METHODS
  Sprague Dawley rats were subjected to severe spinal cord contusion at T8 level or to laminectomy as control. Twenty-four hours after spine surgery, clearance assessments of a single dose of iohexol (120 mg kg(-1)) or of p-aminohippuric acid (PAH, 100 mg kg(-1)) were used to evaluate glomerular filtration rate (GFR) and tubular secretion (TS), respectively. Blood sampling was used to determine concentrations of both compounds by high-performance liquid chromatography for pharmacokinetic measurements.
  
  
  RESULTS
  Iohexol clearance decreased significantly after injury, which resulted in increased concentrations and half-life of iohexol in blood; PAH clearance remained unchanged.
  
  
  CONCLUSIONS
  GFR but not TS is altered during spinal shock. These observations should be of interest to professionals caring for early cord-injured patients, in order to prevent toxicity and therapeutic failure when administering drugs eliminated by the kidney.
authors.affiliation: Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México City, México.
authors.forename: V
authors.initials: V
authors.lastname: Rodríguez-Romero
authors.forename: L
authors.initials: L
authors.lastname: Cruz-Antonio
authors.forename: R E
authors.initials: RE
authors.lastname: Franco-Bourland
authors.forename: G
authors.initials: G
authors.lastname: Guízar-Sahagún
authors.forename: G
authors.initials: G
authors.lastname: Castañeda-Hernández
mesh_terms: D000208:Acute Disease; D000818:Animals; D005260:Female; D005919:Glomerular Filtration Rate; D007472:Iohexol / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000503:physiopathology*; D010130:p-Aminohippuric Acid / Q000494:pharmacology*
chemical_list: D007472:Iohexol; D010130:p-Aminohippuric Acid