title: Associations between human herpesvirus-6, human papillomavirus and cervical cancer.
abstract: Cervical cancer (CxCa) is the second most common cancer among women globally. Human papillomavirus (HPV) infection is thought to be a necessary, but not sufficient, causal factor in CxCa development. Why some women are able to clear HPV infection with no adverse effects, whereas others develop cancer, remains unclear. HHV-6 has demonstrated transformative abilities and has been shown to be present in the genital tract. However, based on the current evidence, we cannot conclude that HHV-6 is a co-factor in HPV-associated carcinogenesis. Nonetheless, future research is warranted because of several crucial gaps in the literature.
authors.affiliation: Dan L Duncan Cancer Center and Department of Pediatrics, Baylor College of Medicine, 1 Baylor Plaza MSBCM305, Houston, TX 77030, USA.
authors.forename: E Susan
authors.initials: ES
authors.lastname: Amirian
authors.forename: Karen
authors.initials: K
authors.lastname: Adler-Storthz
authors.forename: Michael E
authors.initials: ME
authors.lastname: Scheurer
mesh_terms: D002471:Cell Transformation, Neoplastic; D060085:Coinfection / Q000150:complications / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D018450:Disease Progression; D005260:Female; D015654:Herpesvirus 6, Human / Q000378:metabolism; D006801:Humans; D027383:Papillomaviridae / Q000378:metabolism; D030361:Papillomavirus Infections / Q000150:complications*; D019349:Roseolovirus Infections / Q000150:complications*; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000821:virology
chemical_list: D004279:DNA, Viral