title: β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications.
abstract: We present synthesis of highly uniform magnetic nanocomposite material possessing an assortment of important functionalities: magnetism, luminescence, cell-targeting, and hydrophobic drug delivery. Magnetic particle Fe3O4 is encapsulated within a shell of SiO2 that ensures biocompatibility of the nanocomposite as well as act as a host for fluorescent dye (FITC), cancer-targeting ligand (folic acid), and a hydrophobic drug storage-delivering vehicle (β-cyclodextrin). Our preliminary results suggest that such core-shell nanocomposite can be a smart theranostic candidate for simultaneous fluorescence imaging, magnetic manipulation, cancer cell-targeting and hydrophobic drug delivery.
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore. cheazmb@nus.edu.sg
authors.forename: Abu Zayed Md
authors.initials: AZ
authors.lastname: Badruddoza
authors.forename: Md Taifur
authors.initials: MT
authors.lastname: Rahman
authors.forename: Sudipa
authors.initials: S
authors.lastname: Ghosh
authors.forename: Md Zakir
authors.initials: MZ
authors.lastname: Hossain
authors.forename: Jizhong
authors.initials: J
authors.lastname: Shi
authors.forename: Kus
authors.initials: K
authors.lastname: Hidajat
authors.forename: Mohammad Shahab
authors.initials: MS
authors.lastname: Uddin
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D003952:Diagnostic Imaging; D016503:Drug Delivery Systems; D016650:Fluorescein-5-isothiocyanate; D005453:Fluorescence; D005492:Folic Acid / Q000008:administration & dosage / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D019301:Oleic Acid / Q000737:chemistry; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000737:chemistry*; D014212:Tretinoin / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D058185:Magnetite Nanoparticles; D047392:beta-Cyclodextrins; D019301:Oleic Acid; D014212:Tretinoin; D012822:Silicon Dioxide; D005492:Folic Acid; D016650:Fluorescein-5-isothiocyanate; C031215:betadex