title: [Use of BRAF V600E mutation in the differential diagnosis of follicular and papillary tumors of the thyroid and for the optimization of thearpy].
abstract: A possibility of detection of BRAF mutation has been studied by means of polymerase chain reaction in punctate from the thyroid node with the aim of diagnostics of high-differentiated cancer on pre-operative stage. A study includes 94 patients with nodal lesions of the thyroid. According to cytological investigation of material, received by fine-needle aspiration biopsy, papillary thyroid cancer was revealed in 47 patients, follicular tumor-in 35 and nodal colloid goiter in 12 patients. In case of papillary thyroid cancer data of genetic analysis showed the following indices of sensitivity, specificity and diagnostic accuracy: 86%, 100% and 92% correspondingly. Detection of BRAF mutation could be used in pre-operative differential diagnostics of high-differentiated cancer and benign nodal lesions of the thyroid.
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Semënov
authors.forename: M E
authors.initials: ME
authors.lastname: Boriskova
authors.forename: M I
authors.initials: MI
authors.lastname: Zaraĭskiĭ
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Saburova
authors.forename: P A
authors.initials: PA
authors.lastname: Pankova
authors.forename: U V
authors.initials: UV
authors.lastname: Farafonova
authors.forename: M A
authors.initials: MA
authors.lastname: Bykov
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D000328:Adult; D044963:Biopsy, Fine-Needle; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D018698:Glutamic Acid; D006042:Goiter / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D014633:Valine
chemical_list: D018698:Glutamic Acid; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D014633:Valine