title: Preventive effects of ophiopogon-polysaccharide on apiponectin in gestational diabetes mellitus rat.
abstract: OBJECTIVE
  To investigate the effect of ophiopogon-polysaccharide on adiponectin (APN) in gestational diabetic mellitus rat.
  
  
  METHODS
  The model of gestational diabetes mellitus rat were established with streptozotocin by intraperitoneal injection. Model rats were randomly divided into ophiopogon-polysaccharide 125 mg/kg group, 250 mg/kg group, 500 mg/kg group, GDM group and normal pregnancy group (n=10). Ophiopogon-polysaccharide was given by intragastric administration for 14 days. The fasting blood glucose levels of rats at the 0, 7, 14 day were detected respectively. The serum insulin level and APN in fat tissue and placenta were detected at the 14 day.
  
  
  RESULTS
  The fasting blood glucose level, serum insulin level and APN mRNA in fat tissue and placenta were significantly decreased in gestational diabetes rats treated by ophiopogon-polysaccharide compared with model group (P < 0.05).
  
  
  CONCLUSIONS
  Ophiopogon-polysaccharide could decrease the fasting blood glucose level and serum insulin level, and improve APN mRNA in fat tissue and placenta.
authors.affiliation: Obstetrical Department, Shandong Provincial Hospital, Shandong Jinan 250021, China. xiaofan79@126.com
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000517:prevention & control*; D016640:Diabetes, Gestational / Q000097:blood / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D005260:Female; D007328:Insulin / Q000378:metabolism; D031441:Ophiopogon; D008517:Phytotherapy / Q000379:methods; D010920:Placenta / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D010936:Plant Extracts; D011134:Polysaccharides