title: [Technical study of vinpocetine micelles prepared by thin-film hydration method].
abstract: OBJECTIVE
  To prepare PEG-PLA polymeric micelles loaded with vinpocetine (VP).
  
  
  METHODS
  VP micelles were prepared by thin-film hydration method, single factors affecting drug loading content, encapsulation efficiency, productivity, particle size and polydispersity index (PDI) such as dosage, type of organic solvent, quantity of organic solvent, hydration temperature, hydration speed, amount of hydration water, hydration time were investigated, and the optimum technology was obtained. The mean particle size and PDI were determined by DLS. The drug loading content, encapsulation efficiency, productivity of VP micelles were investigated by UV.
  
  
  RESULTS
  The drug loading content and particle size of VP micelles were 20.35% and 118.3 nm, respectively.
  
  
  CONCLUSIONS
  The technology of VP micelles prepared by thin-film hydration method is practical and simple. It's valuable to be further studied.
authors.affiliation: Department of Pharmacology, Guangdong General Hospital, Guangzhou 510080, China. zhijunh517@126.com
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Huang
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Guo
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Wang
authors.forename: Meng-Qi
authors.initials: MQ
authors.lastname: Yang
authors.forename: Shu-Ling
authors.initials: SL
authors.lastname: Huang
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Shao-Na
authors.initials: SN
authors.lastname: Dian
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D008823:Micelles; D010316:Particle Size; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000008:administration & dosage / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D014748:Vinca Alkaloids / Q000008:administration & dosage / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D008823:Micelles; D012997:Solvents; D014748:Vinca Alkaloids; C542623:monomethoxypolyethyleneglycol-polylactide block copolymer; D014867:Water; D011092:Polyethylene Glycols; C013983:vinpocetine