title: The relation between salivary cortisol and the metabolic syndrome score in girls.
abstract: OBJECTIVE
  This study investigated the relation between salivary cortisol and the metabolic syndrome (MetSyn) score in young girls.
  
  
  METHODS
  Twenty-three girls (8.4 ± 0.9 years) had a fasting blood draw to measure high-density lipoprotein (HDL), glucose, and triglyceride concentrations. Waist circumference and blood pressure were also measured. Saliva samples were collected three times (upon waking, 30 min post-waking, and in the evening) at home to measure cortisol levels. A continuous MetSyn score was created from blood pressure, waist circumference, HDL, triglyceride, and glucose values. Correlations examined the unadjusted associations between cortisol values, MetSyn score, and its related components. Regression analysis examined the relation between cortisol values, the MetSyn score, and its related components adjusting for breast development.
  
  
  RESULTS
  The MetSyn score was not related with cortisol values; however, HDL was negatively related with 30-min post-waking, evening, and area under the curve cortisol levels. Triglycerides were positively related to the 30-min post-waking and area under the curve values. These relations existed after adjusting for breast development.
  
  
  CONCLUSIONS
  While the MetSyn score was not related, specific MetSyn components were related to salivary cortisol levels. Cortisol may be involved in the development of some MetSyn components.
authors.forename: Katrina D
authors.initials: KD
authors.lastname: DuBose
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: McKune
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002648:Child; D002940:Circadian Rhythm; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000097:blood; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology*; D009657:North Carolina / Q000453:epidemiology; D012044:Regression Analysis; D012307:Risk Factors; D012463:Saliva / Q000737:chemistry*; D012720:Severity of Illness Index; D013312:Stress, Physiological; D013315:Stress, Psychological / Q000097:blood / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008075:Lipoproteins, HDL; D014280:Triglycerides; D006854:Hydrocortisone