title: A personalized automated messaging system to improve adherence to prostate cancer screening: research protocol.
abstract: BACKGROUND
  Public adherence to cancer screening guidelines is poor. Patient confusion over multiple recommendations and modalities for cancer screening has been found to be a major barrier to screening adherence. Such problems will only increase as screening guidelines and timetables become individualized.
  
  
  OBJECTIVE
  We propose to increase compliance with cancer screening through two-way rich media mobile messaging based on personalized risk assessment.
  
  
  METHODS
  We propose to develop and test a product that will store algorithms required to personalize cancer screening in a central database managed by a rule-based workflow engine, and implemented via messaging to the patient's mobile phone. We will conduct a randomized controlled trial focusing on prostate cancer screening to study the hypothesis that mobile reminders improve adherence to screening guidelines. We will also explore a secondary hypothesis that patients who reply to the messaging reminders are more engaged and at lower risk of non-adherence. We will conduct a randomized controlled trial in a sample of males between 40 and 75 years (eligible for prostate cancer screening) who are willing to receive text messages, email, or automated voice messages. Participants will be recruited from a primary care clinic and asked to schedule prostate cancer screening at the clinic within the next 3 weeks. The intervention group will receive reminders and confirmation communications for making an appointment, keeping the appointment, and reporting the test results back to the investigators. Three outcomes will be evaluated: (1) the proportion of participants who make an appointment with a physician following a mobile message reminder, (2) the proportion of participants who keep the appointment, and (3) the proportion of participants who report the results of the screening (via text or Web).
  
  
  RESULTS
  This is an ongoing project, supported by by a small business commercialization grant from the National Center for Advancing Translational Sciences of the National Institutes of Health.
  
  
  CONCLUSIONS
  We believe that the use of centralized databases and text messaging could improve adherence with screening guidelines. Furthermore, we anticipate this method of increasing patient engagement could be applied to a broad range of health issues, both inside and outside of the context of cancer. This project will be an important first step in determining the feasibility of personalized text messaging to improve long-term adherence to screening recommendations.
authors.affiliation: Ringful Health, LLC, Austin, TX, United States. michael@ringful.com.
authors.forename: Michael Juntao
authors.initials: MJ
authors.lastname: Yuan
authors.forename: Emily T
authors.initials: ET
authors.lastname: Hébert
authors.forename: Ron K
authors.initials: RK
authors.lastname: Johnson
authors.forename: Ju
authors.initials: J
authors.lastname: Long
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Vandewater
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Vickers
keywords: Early Detection of Cancer; Prostatic Neoplasms; Text Messaging