title: Primary hepatic and hepatosplenic diffuse large B-cell lymphomas with intrasinusoidal and interstitial lymphomatous infiltration.
abstract: Primary hepatic and hepatosplenic diffuse large B-cell lymphomas (DLBCLs) are rare cancers and form nodules in most instances. However, very rare cases can diffusely infiltrate the whole liver without nodules. The general clinicopathological features of these lymphomas have not been reported to date. In our current study, we attempted to elucidate the features of these lesions through our direct observations and by reviewing the current literature. We describe the characteristics of 2 patients with hepatic and hepatosplenic DLBCL by autopsy. The lymphoma cells showed diffuse infiltration of the liver, red pulp of the spleen, and bone marrow with intrasinusoidal and interstitial lymphomatous infiltration of the organs. We discuss our observations in relation to previously reported DLBCLs with a similar pathology.
authors.affiliation: 1Matsudo City Hospital, Matsudo, Chiba, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kashimura
authors.forename: Kayoko
authors.initials: K
authors.lastname: Murayama
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000503:physiopathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology* / Q000503:physiopathology; D013160:Splenic Neoplasms / Q000473:pathology* / Q000503:physiopathology
keywords: bone marrow; diffuse large B-cell lymphoma; interstitial lymphomatous infiltration; intrasinusoidal lymphomatous infiltration; liver; splenic red pulp