title: Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction.
abstract: Oxidative stress in heart failure or during ischemia/reperfusion occurs as a result of the excessive generation or accumulation of free radicals or their oxidation products. Free radicals formed during oxidative stress can initiate lipid peroxidation, oxidize proteins to inactive states and cause DNA strand breaks. Oxidative stress is a condition in which oxidant metabolites exert toxic effects because of their increased production or an altered cellular mechanism of protection. In the early phase of acute heart ischemia cytokines have the feature to be functional pleiotropy and redundancy, moreover, several cytokines exert similar and overlapping actions on the same cell type and one cytokine shows a wide range of biological effects on various cell types. Activation of cytokine cascades in the infarcted myocardium was established in numerous studies. In experimental models of myocardial infarction, induction and release of the pro-inflammatory cytokines like TNF-α (Tumor Necrosis Factor α), IL-1β (Interleukin- 1β) and IL-6 (Interleukin-6) and chemokines are steadily described. The current review examines the role of oxidative stress and pro-inflammatory cytokines response following acute myocardial infarction and explores the inflammatory mechanisms of cardiac injury.
authors.forename: Margherita
authors.initials: M
authors.lastname: Neri
authors.forename: Vittorio
authors.initials: V
authors.lastname: Fineschi
authors.forename: Marco
authors.initials: M
authors.lastname: Di Paolo
authors.forename: Cristoforo
authors.initials: C
authors.lastname: Pomara
authors.forename: Irene
authors.initials: I
authors.lastname: Riezzo
authors.forename: Emanuela
authors.initials: E
authors.lastname: Turillazzi
authors.affiliation: Department of Forensic Pathology, University of Foggia, Ospedale Colonnello D'Avanzo, Viale degli Aviatori 1, 71100 Foggia, Italy. marghertaneri@hotmail.com.
authors.forename: Daniela
authors.initials: D
authors.lastname: Cerretani
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D006333:Heart Failure / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology*; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D016207:Cytokines