title: Gene regulatory networks governing pancreas development.
abstract: Elucidation of cellular and gene regulatory networks (GRNs) governing organ development will accelerate progress toward tissue replacement. Here, we have compiled reference GRNs underlying pancreas development from data mining that integrates multiple approaches, including mutant analysis, lineage tracing, cell purification, gene expression and enhancer analysis, and biochemical studies of gene regulation. Using established computational tools, we integrated and represented these networks in frameworks that should enhance understanding of the surging output of genomic-scale genetic and epigenetic studies of pancreas development and diseases such as diabetes and pancreatic cancer. We envision similar approaches would be useful for understanding the development of other organs.
authors.affiliation: Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA.
authors.forename: H Efsun
authors.initials: HE
authors.lastname: Arda
authors.forename: Cecil M
authors.initials: CM
authors.lastname: Benitez
authors.forename: Seung K
authors.initials: SK
authors.lastname: Kim
mesh_terms: D061354:Acinar Cells / Q000166:cytology / Q000378:metabolism; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D054337:Cell Dedifferentiation; D002454:Cell Differentiation; D019295:Computational Biology / Q000379:methods; D057225:Data Mining; D003920:Diabetes Mellitus / Q000235:genetics; D053263:Gene Regulatory Networks; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D059372:Nucleotide Motifs; D010179:Pancreas / Q000166:cytology* / Q000254:growth & development*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D009419:Nerve Tissue Proteins; C498695:NEUROG3 protein, human