title: Inducing effect of testosterone on the hepatic reduction of zearalenone in the female prepubertal rat.
abstract: The prepubertal responsiveness of 3α-hydroxysteroid dehydrogenase and zeara-lenone-reducing activity to either a large subcutaneous dose of testosterone or dietary zearalenone was investigated in female rats. Testosterone induced both the activity of the 3α-hydroxysteroid dehydrogenase, with androsterone as substrate, and zearalenone reduction to α- and (β-zearalenol. Zearalenone had no effect on the activity of 3α-hydroxysteroid dehydrogenase, but had a slight inducing effect on the zearalenone reduction to β-zearalenol. Both testosterone and zearalenone had a growth-promoting effect on uterus.
authors.affiliation: Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, S-75007, Uppsala.
authors.forename: M
authors.initials: M
authors.lastname: Olsen