title: Intracellular pathogen detection by RIG-I-like receptors.
abstract: The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses against viral infections that serve to limit virus replication and to stimulate adaptive immunity. RLRs are cytosolic sensors for virus-derived RNA and thus responsible for intracellular immune surveillance against infection. RLR signaling requires the adapter protein MAVS to induce type I interferon, interferon-stimulated genes, and proinflammatory cytokines. This review focuses on the molecular and cell biological requirements for RLR signal transduction.
authors.affiliation: Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Dixit
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Kagan
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000378:metabolism* / Q000502:physiology; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D000072640:Interferon-Induced Helicase, IFIH1; D007424:Intracellular Fluid / Q000276:immunology / Q000378:metabolism / Q000382:microbiology* / Q000821:virology*; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology; D020365:RNA Helicases / Q000378:metabolism / Q000502:physiology; D012327:RNA Virus Infections / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D051192:Receptors, Pattern Recognition / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000276:immunology; D000097905:Roundabout Proteins
chemical_list: D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D000072640:Interferon-Induced Helicase, IFIH1; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D020365:RNA Helicases; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D051192:Receptors, Pattern Recognition; C118348:Robo3 protein, mouse; D000097905:Roundabout Proteins; C547666:Dhx58 protein, mouse; C452820:RIGI protein, human; C452815:IFIH1 protein, human