title: Autophagy and microtubules - new story, old players.
abstract: Both at a basal level and after induction (especially in response to nutrient starvation), the function of autophagy is to allow cells to degrade and recycle damaged organelles, proteins and other biological constituents. Here, we focus on the role microtubules have in autophagosome formation, autophagosome transport across the cytoplasm and in the formation of autolysosomes. Recent insights into the exact relationship between autophagy and microtubules now point to the importance of microtubule dynamics, tubulin post-translational modifications and microtubule motors in the autophagy process. Such factors regulate signaling pathways that converge to stimulate autophagosome formation. They also orchestrate the movements of pre-autophagosomal structures and autophagosomes or more globally organize and localize immature and mature autophagosomes and lysosomes. Most of the factors that now appear to link microtubules to autophagosome formation or to autophagosome dynamics and fate were identified initially without the notion that sequestration, recruitment and/or interaction with microtubules contribute to their function. Spatial and temporal coordination of many stages in the life of autophagosomes thus underlines the integrative role of microtubules and progressively reveals hidden parts of the autophagy machinery.
authors.affiliation: UPRES EA4530, Université Paris-Sud, Faculté de Pharmacie, 92296 Châtenay-Malabry, France.
authors.forename: Rafah
authors.initials: R
authors.lastname: Mackeh
authors.forename: Daniel
authors.initials: D
authors.lastname: Perdiz
authors.forename: Séverine
authors.initials: S
authors.lastname: Lorin
authors.forename: Patrice
authors.initials: P
authors.lastname: Codogno
authors.forename: Christian
authors.initials: C
authors.lastname: Poüs
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism*; D008954:Models, Biological; D010587:Phagocytosis / Q000502:physiology; D011499:Protein Processing, Post-Translational; D014404:Tubulin / Q000378:metabolism
chemical_list: D014404:Tubulin