title: Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice.
abstract: With the goal of discovering genes that contribute to late-onset neurological and ocular disorders and also genes that extend the healthy life span in mammals, we are phenotyping mice carrying new mutations induced by the chemical N-ethyl-N-nitrosourea (ENU). The phenotyping plan includes basic behavioral, neurohistological, and vision testing in sibling cohorts of mice aged to 18 months, and then evaluation for markers of growth trajectory and stress response in these same cohorts aged up to 28 months. Statistical outliers are identified by comparison to test results of similar aged cohorts, and potential mutants are recovered for re-aging to confirm heritability of the phenotype.
authors.affiliation: Life Sciences Division, Oak Ridge National Laboratory, PO Box 2008, Oak Ridge, TN 37831-6420 USA.
authors.forename: Dabney K
authors.initials: DK
authors.lastname: Johnson
authors.forename: Eugene M
authors.initials: EM
authors.lastname: Rinchik
authors.forename: Naima
authors.initials: N
authors.lastname: Moustaid-Moussa
authors.forename: Darla R
authors.initials: DR
authors.lastname: Miller
authors.forename: Robert W
authors.initials: RW
authors.lastname: Williams
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Michaud
authors.forename: Monica M
authors.initials: MM
authors.lastname: Jablonski
authors.forename: Andrea
authors.initials: A
authors.lastname: Elberger
authors.forename: Kristen
authors.initials: K
authors.lastname: Hamre
authors.forename: Richard
authors.initials: R
authors.lastname: Smeyne
authors.forename: Elissa
authors.initials: E
authors.lastname: Chesler
authors.forename: Daniel
authors.initials: D
authors.lastname: Goldowitz
keywords: ENU mutations; age-onset; longevity; neurological disorders; phenotype-screening