title: Severe water intoxication secondary to the concomitant intake of non-steroidal anti-inflammatory drugs and desmopressin: a case report and review of the literature.
abstract: Most of the clinical data on the safety profile of desmopressin (DDAVP), which is an effective treatment for both polyuric conditions and bleeding disorders, originate from studies on the tailoring of drug treatment, whereas few reports exist describing severe side effects secondary to drug-drug interaction. We herein describe a case of severe hyponatremia complicated by seizure and coma due to the intake of non-steroidal anti-inflammatory drugs (NSAIDs) in a patient on DDAVP replacement therapy for central diabetes insipidus (DI). A 50-yr-old Caucasian man, with congenital central DI, developed an episode of generalized tonic-clonic seizure, resulting in coma immediately after being admitted to the Emergency Unit for weakness and emesis. Based on his medical history and clinical findings, water intoxication secondary to ketoprofen intake (200 mg/day for the last 3 days) concomitant with DDAVP replacement therapy (Minirin(®) 60 mcg 4 tablets a day) was hypothesized as being the cause of the severe euvolemic hypotonic hyponatremia (natremia 113 mEq/l, plasma osmolality 238 mOsm/Kg). After standard emergency procedures, appropriate gradual restoration of serum sodium levels to the normal range was achieved in 72 hours. Hydratation was maintained according to water excretion and desmopressin therapy was re-introduced. We discuss this case report in the context of the published literature. The present report first highlights the potentially life-threatening side effects associated with over-the-counter NSAIDs during DDAVP replacement therapy for central DI. Risks and benefits of co-treatment should be carefully considered and therapeutic alternatives to NSAIDs should be recommended to patients with central DI in order to improve DDAVP safety.
authors.affiliation: Department of Clinical Sciences and Community Health, University of Milan, Endocrinology and Diabetology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. elisaverrua@yahoo.it
authors.forename: Elisa
authors.initials: E
authors.lastname: Verrua
authors.forename: Giovanna
authors.initials: G
authors.lastname: Mantovani
authors.forename: Emanuele
authors.initials: E
authors.lastname: Ferrante
authors.forename: Andrea
authors.initials: A
authors.lastname: Noto
authors.forename: Elisa
authors.initials: E
authors.lastname: Sala
authors.forename: Elena
authors.initials: E
authors.lastname: Malchiodi
authors.forename: Gaetano
authors.initials: G
authors.lastname: Iapichino
authors.forename: Paolo Beck
authors.initials: PB
authors.lastname: Peccoz
authors.forename: Anna
authors.initials: A
authors.lastname: Spada
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D050034:Antidiuretic Agents / Q000009:adverse effects*; D003128:Coma / Q000139:chemically induced; D003894:Deamino Arginine Vasopressin / Q000009:adverse effects*; D020790:Diabetes Insipidus, Neurogenic / Q000188:drug therapy*; D004347:Drug Interactions; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced; D007660:Ketoprofen / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D014869:Water Intoxication / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D050034:Antidiuretic Agents; D007660:Ketoprofen; D003894:Deamino Arginine Vasopressin