title: A synthesis of α-amino acids via direct reductive carboxylation of imines with carbon dioxide.
abstract: A method for the synthesis of α-amino acids by direct reductive carboxylation of aromatic imines with CO2 is described. The protocol employs readily available commercial reagents and serves as a one-step alternative to the Strecker synthesis.
authors.affiliation: Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Ajay A
authors.initials: AA
authors.lastname: Sathe
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Hartline
authors.forename: Alexander T
authors.initials: AT
authors.lastname: Radosevich
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002245:Carbon Dioxide / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D000596:Amino Acids; D007097:Imines; D002245:Carbon Dioxide; D008274:Magnesium