title: Myelofibrosis, hepatic extramedullary hematopoiesis and ascites associated with vitamin D deficiency in early infancy.
abstract: Primary myelofibrosis is rare in children. Many causes have been described for secondary myelofibrosis including vitamin D deficiency. Here, we describe a patient with myelofibrosis secondary to vitamin D deficiency, as diagnosed by laboratory evidence. The patient also developed resultant extramedullary hematopoiesis with secondary development of ascites as a result of myelofibrosis. These are findings rarely reported in association with vitamin D deficiency. Potential mechanisms are also discussed.
authors.affiliation: *Carman and Ann Adams Department of Pediatrics, Division of Hematology/Oncology Divisions of ‡Critical Care §Pathology, Children's Hospital of Michigan †Wayne State University, Detroit, MI.
authors.forename: Meret
authors.initials: M
authors.lastname: Henry
authors.forename: Meera
authors.initials: M
authors.lastname: Chitlur
authors.forename: Madhvi
authors.initials: M
authors.lastname: Rajpurkar
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Mastropietro
authors.forename: Janet
authors.initials: J
authors.lastname: Poulik
authors.forename: Yaddanpuddi
authors.initials: Y
authors.lastname: Ravindranath
mesh_terms: D001201:Ascites / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D007223:Infant; D008099:Liver / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D055728:Primary Myelofibrosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D014808:Vitamin D Deficiency / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology