title: How clonal are Trypanosoma and Leishmania?
abstract: The clonal theory of parasitic protozoa has been recently challenged by researchers stating that recombination in Kinetoplastida is much more frequent than previously believed, or that selfing and homogamy should be distinguished from 'strict' clonality. These researchers and many others show that the concept of clonality proposed by us is not correctly understood. A recapitulation of the clonal theory will thus be addressed herein. Comparisons with various other pathogens evidence general features among them and enhance our understanding of Trypanosoma and Leishmania population genetics. The relevance is considerable not only for our knowledge of the basic biology of these organisms but also for applied research: molecular epidemiology (strain-typing), clinical research, vaccine and drug design, and experimental evolution.
authors.affiliation: Maladies Infectieuses et Vecteurs Ecologie, Génétique, Evolution et Contrôle, Institut de Recherche pour le Développement 224-Centre National de la Recherche Scientifique 5290-Unité Mixte 1/2, 34394 Montpellier Cedex 5, France. Michel.Tibayrenc@ird.fr
authors.forename: Michel
authors.initials: M
authors.lastname: Tibayrenc
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Ayala
mesh_terms: D000818:Animals; D005075:Biological Evolution; D014644:Genetic Variation; D006824:Hybridization, Genetic; D007891:Leishmania / Q000145:classification* / Q000235:genetics; D014345:Trypanosoma / Q000145:classification* / Q000235:genetics