title: Effects of isoflurane and propofol on hepatic and renal functions and coagulation profile after right hepatectomy in living donors.
abstract: We compared postoperative hepatic and renal functions and coagulation profiles in living donors undergoing right hepatectomy under isoflurane (n = 40) versus propofol (n = 40) anesthesia. After induction, anesthesia was maintained with isoflurane/air-O2 (group I) or propofol/air-O2 (group P) in addition to remifentanil and atracurium infusion in both groups. Aspartate aminotransferase, alanine aminotransferase, international normalized ratio (INR), activated partial thromboplastin time (aPTT), albumin, total bilirubin, blood urea nitrogen, creatinine, estimated glomerular filtration rate (GFR), platelet count, and hemoglobin levels were measured in the preoperative period, after end of the operation, and on the first, third, fifth and seventh postoperative days (PODs). INR was significantly increased on POD 3 and aPTT on POD 5 in group I compared with group P (P < .05). Albumin level was significantly lower in Group I on POD 1 and 3 (P < .05). GFR was significantly lower on POD 1 in the group I compared with group P (P < .05). The postoperative coagulation, GFR, and albumin values were superior following administration of propofol than isoflurane in donors who underwent living hepatectomy; however, both approaches were clinically safe, with no significant clinical difference.
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Inonu University, Malatya, Turkey. ulku.ozgul@inonu.edu.tr
authors.forename: U
authors.initials: U
authors.lastname: Ozgul
authors.forename: M
authors.initials: M
authors.lastname: Ucar
authors.forename: M A
authors.initials: MA
authors.lastname: Erdogan
authors.forename: M S
authors.initials: MS
authors.lastname: Aydogan
authors.forename: H I
authors.initials: HI
authors.lastname: Toprak
authors.forename: C
authors.initials: C
authors.lastname: Colak
authors.forename: M
authors.initials: M
authors.lastname: Durmus
authors.forename: M O
authors.initials: MO
authors.lastname: Ersoy
mesh_terms: D001777:Blood Coagulation; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006498:Hepatectomy; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D019520:Living Donors; D015742:Propofol / Q000494:pharmacology*
chemical_list: D007530:Isoflurane; D015742:Propofol