title: Synthesis and biological activity of novel series of 1,3-benzoxazol-2(3H)-one derivatives.
abstract: In the search for novel biological agents, a series of new derivatives N-substituted 1,3-benzoxazol-2(3H)-one, 5-chloro-1,3-benzoxazol-2(3H)-one, 6-bromo-1,3-benzoxazol-2(3H)-one were prepared. All of the compounds were characterized by 1H NMR, 13C NMR and ESI MS spectra. Moreover, for compound 1 an Xray structure was determined. All derivatives were tested for antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts. The selected compounds (2-8, 10) were tested for their cytotoxic properties in K562, HeLa and normal cells.
authors.affiliation: Department of Medical Chemistry, Medical University of Warsaw, 3 Oczki St., 02-007 Warszawa, Poland.
authors.forename: Mariola
authors.initials: M
authors.lastname: Krawiecka
authors.forename: Bozena
authors.initials: B
authors.lastname: Kuran
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kossakowski
authors.forename: Marta
authors.initials: M
authors.lastname: Kierzkowska
authors.forename: Grazyna
authors.initials: G
authors.lastname: Młynarczyk
authors.forename: Marcin
authors.initials: M
authors.lastname: Cieślak
authors.forename: Julia
authors.initials: J
authors.lastname: Kaźmierczak-Barańska
authors.forename: Karolina
authors.initials: K
authors.lastname: Królewska
authors.forename: Michał A
authors.initials: MA
authors.lastname: Dobrowolski
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006367:HeLa Cells; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship; D015003:Yeasts / Q000187:drug effects / Q000254:growth & development
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001583:Benzoxazoles; C017057:benzoxazolone