title: A triploid partial mole placenta from paternal isodisomy with a diploid fetus derived from one sperm and one oocyte may have caused angiogenic imbalance leading to preeclampsia-like symptoms at 19 weeks of gestation.
abstract: Partial hydatidiform mole with a normal fetus is extremely rare. A 30-year-old woman presented at 19 weeks gestation with clinical manifestations of severe preeclampsia. The fetus revealed a normal 46,XX karyotype and the placenta revealed triploid 69,XXX from paternal isodisomy. Microsatellite analysis revealed that the fetus and the triploid partial mole were derived from one sperm and one oocyte, followed by duplication of paternal chromosomes in only a trophectodermal cell. The maternal serum levels of angiogenic factors were extremely high compared with those reported in preeclampsia, suggesting an angiogenic imbalance may have caused preeclampsia-like symptoms before 20 weeks of gestation.
authors.affiliation: Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yoneda
authors.forename: A
authors.initials: A
authors.lastname: Shiozaki
authors.forename: K
authors.initials: K
authors.lastname: Miura
authors.forename: R
authors.initials: R
authors.lastname: Yonezawa
authors.forename: K
authors.initials: K
authors.lastname: Takemura
authors.forename: S
authors.initials: S
authors.lastname: Yoneda
authors.forename: H
authors.initials: H
authors.lastname: Masuzaki
authors.forename: S
authors.initials: S
authors.lastname: Saito
mesh_terms: D000328:Adult; D042501:Angiogenic Proteins / Q000097:blood*; D004171:Diploidy; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics*; D008297:Male; D009865:Oocytes; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood; D011262:Pregnancy Trimester, Second; D013094:Spermatozoa; D057885:Triploidy; D024182:Uniparental Disomy / Q000235:genetics; D014594:Uterine Neoplasms / Q000235:genetics*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood
chemical_list: D042501:Angiogenic Proteins; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1