title: Methods of tracing hydrogen in polyketide biosynthesis: High field NMR spectroscopy of citrinin produced in a D2O based medium.
abstract: Penicillium citrinum cultures have been germinated on an H2O-based medium, resuspended on a D2O-based medium and treated with [l,2-(13)C2] acetate. The resulting citrinin (1) has been analysed by(2)H and(13)C nuclear magnetic resonance spectroscopy and information about the metabolism of hydrogen in citrinin biosynthesis has been deduced.
authors.affiliation: Department of Pharmacy, University of Manchester, M13 9 PL, Manchester, UK.
authors.forename: J
authors.initials: J
authors.lastname: Barber
authors.forename: A C
authors.initials: AC
authors.lastname: Chapman
authors.forename: T D
authors.initials: TD
authors.lastname: Howard