title: Influence of pretreatment ideal body weight percentile and albumin on prognosis of nasopharyngeal carcinoma: Long-term outcomes of 512 patients from a single institution.
abstract: BACKGROUND
  The purpose of this study was to investigate the relationship between pretreatment nutritional status and prognosis of nasopharyngeal carcinoma (NPC).
  
  
  METHODS
  Pretreatment nutritional status was evaluated by ideal body weight percentile (IBW%) and serum albumin for 512 patients with NPC who underwent radical radiotherapy. Kaplan-Meier methods, log-rank test, and a Cox model were applied for survival analysis.
  
  
  RESULTS
  Before radiotherapy, IBW% <90% was related to poorer overall survival (OS) and distant metastasis-free survival (DMFS; p = .031 and p = .012, respectively); albumin ≤43.0 g/L was related to poorer OS and DMFS (p < .001 and p = .042, respectively); both IBW% and albumin were independent prognostic factors for OS; those patients with IBW% <90% and albumin ≤43.0 g/L simultaneously had the worst OS and DMFS.
  
  
  CONCLUSIONS
  Decrease of pretreatment IBW% and albumin was related to poorer survival of NPC.
authors.affiliation: State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University, Guangzhou, People's Republic of China; Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China; Department of Radiation Oncology, Guangzhou Medical University Cancer Institute and Hospital, Guangzhou, People's Republic of China.
authors.forename: Guo
authors.initials: G
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Gao
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Liu
authors.forename: Ya-Lan
authors.initials: YL
authors.lastname: Tao
authors.forename: Bing-Qing
authors.initials: BQ
authors.lastname: Xu
authors.forename: Zi-Wei
authors.initials: ZW
authors.lastname: Tu
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Zhang
authors.forename: Mu-Sheng
authors.initials: MS
authors.lastname: Zeng
authors.forename: Yun-Fei
authors.initials: YF
authors.lastname: Xia
mesh_terms: D000328:Adult; D002277:Carcinoma; D015331:Cohort Studies; D016001:Confidence Intervals; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D056865:Ideal Body Weight / Q000502:physiology*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D009752:Nutritional Status; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012372:ROC Curve; D018570:Risk Assessment; D012709:Serum Albumin / Q000032:analysis*; D018709:Statistics, Nonparametric; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D012709:Serum Albumin
keywords: IBW%; albumin; malnutrition; nasopharyngeal carcinoma; prognosis