title: Boronated carbohydrate derivatives as potential boron neutron capture therapy reagents.
abstract: The treatment of cancer remains one of the most challenging problems for humanity. Boron neutron capture therapy is a binary approach for cancer treatment that is particularly attractive in treating high-grade gliomas and metastatic brain tumors. Among the types of boron-containing molecules used as boron neutron capture therapy agents, boronated carbohydrate derivatives have received significant attention because of their preferential uptake by growing tumor cells. This review provides a summary of the recent developments in the chemistry of carborane-containing carbohydrates.
authors.affiliation: Departments of Chemistry & Radiology, The University of Tennessee, Knoxville, TN 37996-1600, USA.
authors.forename: Srinivasa R
authors.initials: SR
authors.lastname: Marepally
authors.forename: Min-Liang
authors.initials: ML
authors.lastname: Yao
authors.forename: George W
authors.initials: GW
authors.lastname: Kabalka
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D001880:Boranes / Q000737:chemistry; D016754:Boron Neutron Capture Therapy; D001897:Boronic Acids / Q000737:chemistry*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002241:Carbohydrates / Q000737:chemistry*; D005690:Galactose / Q000737:chemistry; D005910:Glioma / Q000532:radiotherapy*; D005947:Glucose / Q000737:chemistry; D006801:Humans; D007785:Lactose / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D001880:Boranes; D001897:Boronic Acids; D002241:Carbohydrates; D005947:Glucose; D007785:Lactose; D005690:Galactose