title: "Simple febrile seizures plus (SFS+)": more than one febrile seizure within 24 hours is usually okay.
abstract: This study aimed to investigate whether children with recurrent febrile seizures within a 24-hour period need to be worked up differently from children with simple febrile seizures. Inclusion criteria included the following: (i) children with first seizure cluster between 4 months and 3 years of age, (ii) children who had more than one febrile seizure within 24 hours, and (iii) children who returned to baseline between and after each event. Thirty-two patients met the inclusion criteria over a 3-year period. All patients underwent brain CT and/or MRI and EEG. All head CTs were normal. Two children had abnormal MRI findings - both benign: one is thought to represent postictal changes, and the other one is an incidental arachnoid cyst. Of the 4 abnormal EEGs, one showed epileptiform discharges, while the others showed generalized ictal or postictal features. We propose the term "simple febrile seizures plus (SFS+)" to describe children who have more than one seizure within 24 hours but who are otherwise not different in presentation from children with SFS.
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, 4M62 Box 0870, San Francisco, CA 94110, USA.
authors.forename: Marie F
authors.initials: MF
authors.lastname: Grill
authors.forename: Yu-Tze
authors.initials: YT
authors.lastname: Ng
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012189:Retrospective Studies; D003294:Seizures, Febrile / Q000145:classification* / Q000503:physiopathology*; D013997:Time Factors; D055815:Young Adult