title: Paraneoplastic disorders of the peripheral nervous system.
abstract: Paraneoplastic neurological syndromes are rare but can affect any part of the peripheral nervous system (PNS) including motor neurons, sensory ganglia, nerve roots, plexuses, cranial and peripheral nerves, and neuromuscular junctions. The type of cancer, lymphoma or solid tumour, is a determinant factor of the underlying mechanism. With solid tumour, antibodies directed to intracellular (anti-Hu or anti-CV2/CRMP5 antibodies) or surface antigens (anti-VGCC,or LGI1 and Caspr2 antibodies) have been identified while with lymphoma, the neuropathy is usually linked to a monoclonal gammopathy. This review discusses the different etiologies and mechanisms of paraneoplastic disorders of the PNS in patients emphasising their evaluation, diagnosis and treatment.
authors.affiliation: Department of Neurology, University Hospital of Saint-Étienne, Saint-Étienne, France. j.christophe.antoine@chu-st-etienne.fr
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Antoine
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Camdessanché
mesh_terms: D001323:Autoantibodies; D006801:Humans; D009369:Neoplasms / Q000276:immunology*; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy
chemical_list: D001323:Autoantibodies