title: Dye laser photodynamic therapy for Bowen's disease in a patient with epidermodysplasia verruciformis.
abstract: Epidermodysplasia verruciformis (EV) is a rare heritable skin disease that results in unusual susceptibility to infection with specific types of human papillomavirus (HPV). Here we report a 53-year-old man with EV who developed Bowen's disease on his lower eyelid and the chest. Mutation analysis of EVER1 gene revealed homozygous splice acceptor site mutation (IVS8-2, A > T). In this patient, HPV3, HPV14, and HPV38 had been identified from the skin lesions. The Bowen's skin lesion on the left lower eye-lid was treated by photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) and pulsed dye laser (PDL). After two rounds of the PDT treatment, the skin lesion disappeared and a skin biopsy confirmed the efficacy of the treatment. This method was simple, less invasive than other treatments, and achieved a satisfactory cosmetic result.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Osaka City University, Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Sunohara
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ozawa
authors.forename: Kuniyuki
authors.initials: K
authors.lastname: Morimoto
authors.forename: Teruichi
authors.initials: T
authors.lastname: Harada
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Ishii
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Fukai
mesh_terms: D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D001706:Biopsy; D001913:Bowen's Disease / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D004819:Epidermodysplasia Verruciformis / Q000150:complications / Q000235:genetics / Q000821:virology*; D005142:Eyelid Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D006801:Humans; D054025:Lasers, Dye; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008875:Middle Aged; D009154:Mutation; D010778:Photochemotherapy / Q000295:instrumentation*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D016896:Treatment Outcome
chemical_list: D008565:Membrane Proteins; D017319:Photosensitizing Agents; C470314:TMC6 protein, human; C470315:TMC8 protein, human; D000622:Aminolevulinic Acid