title: Influence of dietary fibre on plasma and urinary levels of zearalenone and metabolites in swine.
abstract: The effect of dietary fibre on zearalenone absorption, metabolic pathway and urinary excretion was investigated in a prepubertal gilt. Levels of zearalenone and metabolites were measured in the portal vein, in the carotid artery and in urine after feeding one portion of a standard diet or a high fibre diet (85 % standard diet + 15 % oat husks), both containing 5 ppm zearalenone. Independently of diet, the levels of zearalenone in the portal vein were higher than in the carotid artery during the following 48 hrs. Regarding the metabolite α-zearalenol, strikingly lower systemic levels were observed when high fibre diet was fed to the animal. The decrease of α-zearalenol level, due to high fibre diet, was also reflected in urine. The total amount of zearalenone and α-zearalenol excreted in urine, during 24 hours after feeding, was about 9 % of the zearalenone intake, independently of diet. Almost all zearalenone and α-zearalenol were found conjugated with glucuronic acid in both plasma and urine.
authors.affiliation: Biology section, National Food Administration, S-751 26, Uppsala, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Olsen
authors.forename: K
authors.initials: K
authors.lastname: Malmlöf
authors.forename: H
authors.initials: H
authors.lastname: Pettersson
authors.forename: J
authors.initials: J
authors.lastname: Grajewski