title: Sequential C-H functionalization reactions for the enantioselective synthesis of highly functionalized 2,3-dihydrobenzofurans.
abstract: The enantioselective synthesis of 2,3-dihydrobenzofurans was achieved by using two sequential C-H functionalization reactions, a rhodium-catalyzed enantioselective intermolecular C-H insertion followed by a palladium-catalyzed C-H activation/C-O cyclization. Further diversification of the 2,3-dihydrobenzofuran structures was possible by a subsequent palladium-catalyzed intermolecular Heck-type sp(2) C-H functionalization.
authors.affiliation: Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
authors.forename: Hengbin
authors.initials: H
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Keary M
authors.initials: KM
authors.lastname: Engle
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
authors.forename: Huw M L
authors.initials: HM
authors.lastname: Davies
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001572:Benzofurans; C043168:coumaran