title: Platelet oxidative stress and systemic inflammation in chronic spontaneous urticaria.
abstract: BACKGROUND
  Recent studies implicate the role of immune-inflammatory responses in chronic spontaneous urticaria (CSU). Although it is well known that platelets release inflammatory mediators and reactive oxygen species upon activation, their role in CSU is poorly characterized. The present study was designed to evaluate platelet oxidative stress [platelet malondialdehyde (MDA), platelet superoxide dismutase (SOD), platelet glutathione peroxidase (GPx)] and systemic inflammatory markers [plasma Interleukin-6 (IL-6), high sensitivity C-reactive protein (hs-CRP)] in patients with CSU and their association with disease severity.
  
  
  METHODS
  Forty-five patients with CSU and 45 age- and gender-matched healthy controls were included in the study. Severity grading was completed according to the urticaria severity score (USS). Autologous plasma skin test (APST) was done in all patients with CSU. Platelet MDA, SOD and GPx and inflammatory markers plasma IL-6 and hs-CRP were assayed in all study participants.
  
  
  RESULTS
  In patients with CSU, platelet SOD and GPx were significantly lowered, while platelet MDA levels were significantly elevated in comparison to healthy controls. Both IL-6 and hs-CRP were significantly elevated in patients with CSU and correlated with platelet oxidative stress parameters (p<0.05). Platelet MDA, SOD and GPx and inflammatory markers (plasma IL-6 and hs-CRP) showed a significant correlation with USS in patients with CSU.
  
  
  CONCLUSIONS
  Our results indicate significant systemic inflammation and platelet oxidative stress in patients with CSU.
authors.forename: Medha
authors.initials: M
authors.lastname: Rajappa
authors.forename: Laxmisha
authors.initials: L
authors.lastname: Chandrashekar
authors.forename: Indhumathi
authors.initials: I
authors.lastname: Sundar
authors.forename: Malathi
authors.initials: M
authors.lastname: Munisamy
authors.forename: P H
authors.initials: PH
authors.lastname: Ananthanarayanan
authors.forename: Devinder Mohan
authors.initials: DM
authors.lastname: Thappa
authors.forename: Pampa Ch
authors.initials: PCh
authors.lastname: Toi
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism*; D016022:Case-Control Studies; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D014581:Urticaria / Q000097:blood*; D055815:Young Adult
chemical_list: D008315:Malondialdehyde