title: Motor functioning during and following treatment with chemotherapy for pediatric acute lymphoblastic leukemia.
abstract: This systematic review evaluated empirical studies examining motor skills in children during and following treatment for acute lymphoblastic leukemia. Most studies indicated that children on-treatment display poorer gross and fine motor abilities than healthy peers, but generally have intact visual-motor integration skills. Studies have reported gross motor difficulties in 5-54% of survivors. There is some limited evidence for long-term fine motor deficits. The evidence for visual-motor integration difficulties in the survivor population is less consistent. Larger studies with a longitudinal design are needed to further specify the onset and timing of motor difficulties and ascertain risk factors.
authors.affiliation: Children's Cancer Centre, Royal Children's Hospital, Melbourne, VIC, Australia.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Green
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Knight
authors.forename: Maria
authors.initials: M
authors.lastname: McCarthy
authors.forename: Cinzia R
authors.initials: CR
authors.lastname: De Luca
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009048:Motor Skills; D019957:Motor Skills Disorders / Q000139:chemically induced / Q000503:physiopathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology*; D012307:Risk Factors; D013997:Time Factors