title: Melanogenesis inhibitory daphnane diterpenoids from the flower buds of Daphne genkwa.
abstract: Two new daphnane-type diterpene esters, daphneresiniferins A (1) and B (2), along with seven known diterpenes, yuanhuacine (3), yuanhuadine (4), yuanhuahine (5), genkwadaphnin (6), genkwanine A (7), genkwanine F (8), and genkwanine H (9), were isolated from the methanol extract of the flower buds of Daphne genkwa. Their structures were elucidated on the basis of spectroscopic methods, especially 2D NMR spectra such as HMQC, HMBC, and NOESY. All the isolates were evaluated for their inhibitory effects of the melanogenesis against α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Kwon Ki
authors.initials: KK
authors.lastname: Bang
authors.forename: Cheong-Yong
authors.initials: CY
authors.lastname: Yun
authors.forename: Chul
authors.initials: C
authors.lastname: Lee
authors.forename: Qinghao
authors.initials: Q
authors.lastname: Jin
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Lee
authors.forename: Sang-Hun
authors.initials: SH
authors.lastname: Jung
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
authors.forename: Youngsoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D032364:Daphne / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D035264:Flowers / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008543:Melanins / Q000378:metabolism*; D051379:Mice; D008968:Molecular Conformation; D000521:alpha-MSH / Q000378:metabolism
chemical_list: D004224:Diterpenes; D008543:Melanins; C584756:daphneresiniferin B; D000521:alpha-MSH