title: Potential of protein kinase inhibitors for treating herpesvirus-associated disease.
abstract: Herpesviruses are ubiquitous human pathogens that establish lifelong persistent infections. Clinical manifestations range from mild self-limiting outbreaks such as childhood rashes and cold sores to the more severe and life-threatening outcomes of disseminated infection, encephalitis, and cancer. Nucleoside analog drugs that target viral DNA replication provide the primary means of treatment. However, extended use of these drugs can result in selection for drug-resistant strains, particularly in immunocompromised patients. In this review we will present recent observations about the participation of cellular protein kinases in herpesvirus biology and discuss the potential for targeting these protein kinases as well as the herpesvirus-encoded protein kinases as an anti-herpesvirus therapeutic strategy.
authors.affiliation: Viral Oncology Program, Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. rli13@jhmi.edu
authors.forename: Renfeng
authors.initials: R
authors.lastname: Li
authors.forename: S Diane
authors.initials: SD
authors.lastname: Hayward
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006564:Herpesviridae / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D006566:Herpesviridae Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D047428:Protein Kinase Inhibitors