title: Asymmetric induction via short-lived chiral enolates with a chiral C-O axis.
abstract: A novel method has been developed for the asymmetric cyclization of alkyl aryl ethers. The reactions were assumed to proceed via short-lived chiral enolate intermediates with a chiral C-O axis to give cyclic ethers with tetrasubstituted carbon in up to 99% ee. The half-life of racemization of the chiral enolate intermediate was roughly estimated to be ~1 s at -78 °C.
authors.affiliation: Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yoshimura
authors.forename: Keisuke
authors.initials: K
authors.lastname: Tomohara
authors.forename: Takeo
authors.initials: T
authors.lastname: Kawabata