title: Protective role of Aralia elata polysaccharide on mercury(II)-induced cardiovascular oxidative injury in rats.
abstract: Mercury(II) is a highly toxic environmental pollutant leading to oxidative stress in animals and human beings. In this study we aimed to investigate the possible protective effect of a water-soluble polysaccharide (AEP-w1) from the root bark of Aralia elata against experimental mercury(II)-induced cardiovascular oxidative injury in rat model. The results showed that delayed AEP-w1 supplement to HgCl2-treated mice not only decreased serum lactate dehydrogenase (LDH) and tumor necrosis factor-α (TNF-α) levels, but also increased serum nitric oxide (NO) metabolite levels and antioxidant capacity. Moreover, AEP-w1 administration to HgCl2-treated mice significantly decreased malondialdehyde (MDA) level and myeloperoxidase (MPO) activity and increased superoxide dismutase (SOD) and catalase (CAT) activities, along with glutathione (GSH) level in rat cardiac tissue. In addition, elevated serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN) and creatinine (Cr) levels in the saline-treated Hg group were also reversed by AEP-w1 treatment. Therefore, the present study demonstrates that alleviation of HgCl2-induced oxidative injury in rat by AEP-w1 contributes to better understanding of its beneficial effect against cardiovascular diseases.
authors.affiliation: Department of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Shaoping
authors.initials: S
authors.lastname: Lu
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wang
authors.forename: Qiangsun
authors.initials: Q
authors.lastname: Zheng
mesh_terms: D000410:Alanine Transaminase / Q000037:antagonists & inhibitors / Q000097:blood; D000818:Animals; D027983:Aralia / Q000737:chemistry*; D001219:Aspartate Aminotransferases / Q000037:antagonists & inhibitors / Q000097:blood; D001806:Blood Urea Nitrogen; D002318:Cardiovascular Diseases / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D002374:Catalase / Q000097:blood; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000037:antagonists & inhibitors; D008627:Mercuric Chloride / Q000633:toxicity*; D009569:Nitric Oxide / Q000819:agonists / Q000097:blood; D018384:Oxidative Stress; D009195:Peroxidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000097:blood
chemical_list: D011134:Polysaccharides; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D008315:Malondialdehyde; D008627:Mercuric Chloride; D007770:L-Lactate Dehydrogenase; D002374:Catalase; D009195:Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase