title: Update on the treatment of juvenile idiopathic arthritis.
abstract: Juvenile idiopathic arthritis (JIA) is one of the most common chronic diseases of childhood. Although the pathophysiology behind this disease is poorly understood, there are effective treatments for JIA based on the subtype of disease. Treatment options include non-steroidal anti-inflammatory drugs, intra-articular glucocorticoid injections, and traditional disease modifying anti-rheumatic drugs such as methotrexate. In the past decade, the use of biologic therapy in JIA, including tumor necrosis factor inhibitors, interleukin-1 inhibitors, and interleukin-6 inhibitors, has dramatically increased with promising outcomes.
authors.affiliation: Division of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, 9000 W. Wisconsin Ave, Wauwatosa, WI 53226, USA. jgharris@mcw.edu
authors.forename: Julia G
authors.initials: JG
authors.lastname: Harris
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Kessler
authors.forename: James W
authors.initials: JW
authors.lastname: Verbsky
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D001691:Biological Therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007375:Interleukin-1 / Q000627:therapeutic use; D015850:Interleukin-6 / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018501:Antirheumatic Agents; D005938:Glucocorticoids; D007155:Immunologic Factors; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D008727:Methotrexate