title: A replication study examining association of rs6983267, rs10090154, and rs1447295 common single nucleotide polymorphisms in 8q24 region with prostate cancer in Siberians.
abstract: BACKGROUND
  Multiple genetic studies have confirmed association of 8q24 variants with susceptibility to prostate cancer (CaP). However, the risk conferred in men living in Russia is unknown.
  
  
  METHODS
  In this work we studied the association of rs6983267, rs10090154, and rs1447295 single nucleotide polymorphisms (SNPs) with a risk of CaP development in men of Caucasoid descent living in the Siberian region of Russia. Three 8q24 SNPs were genotyped by real-time polymerase chain reaction in histologically confirmed CaP "cases" (n = 392) and clinically evaluated "controls" (n = 344). To evaluate the SNP effects on CaP susceptibility, odds ratio (OR) and confidence interval (CI) 95% were calculated. Allele and genotype frequencies in the groups were compared using logistic regression; differences were considered statistically significant if P<0.05.
  
  
  RESULTS
  We showed statistically significant association of the A allele of rs1447295 (OR [CI 95%] = 1.96 [1.37-2.81], P<0.0001) and the T allele of rs10090154 (OR [CI 95%] = 2.14 [1.41-3.26], P<0.0001) with CaP. The T-A rs10090154 to rs1447295 haplotype was also associated with CaP (OR [CI 95%] = 2.47 [1.59-3.85], P<0.0001). There was no significant association with the T allele of rs6983267: OR [CI 95%] = 0.9 [0.73-1.11], P> 0.05.
  
  
  CONCLUSIONS
  Thus, our investigation confirms the role of chromosomal region 8q24 in the development of CaP in the Russian population.
authors.affiliation: Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. Electronic address: nattasha.o@gmail.com.
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Oskina
authors.affiliation: Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: Ulyana A
authors.initials: UA
authors.lastname: Boyarskikh
authors.affiliation: Altai Affiliated Department of Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Barnaul, Russia.
authors.forename: Alexandr F
authors.initials: AF
authors.lastname: Lazarev
authors.affiliation: Altai Affiliated Department of Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Barnaul, Russia.
authors.forename: Valentina D
authors.initials: VD
authors.lastname: Petrova
authors.affiliation: Altai Affiliated Department of Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Barnaul, Russia.
authors.forename: Dmitry I
authors.initials: DI
authors.lastname: Ganov
authors.affiliation: Krasnoyarsk Regional Oncologic Center, Krasnoyarsk, Russia.
authors.forename: Olga G
authors.initials: OG
authors.lastname: Tonacheva
authors.affiliation: Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: Galina I
authors.initials: GI
authors.lastname: Lifshits
authors.affiliation: Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: Maxim L
authors.initials: ML
authors.lastname: Filipenko
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001706:Biopsy; D002898:Chromosomes, Human, Pair 8; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D015203:Reproducibility of Results; D012307:Risk Factors; D012426:Russia
keywords: Prostate cancer; Region of chromosome 8q24; Russian; Single nucleotide polymorphisms (SNPs)