title: Delayed lower cranial neuropathies following primary radiotherapy for oropharyngeal squamous cell carcinoma.
abstract: Delayed lower cranial neuropathy is a rare complication following primary radiotherapy for head and neck cancer, and has been most associated with nasopharyngeal carcinoma with minimal data regarding this outcome in the treatment of the oropharynx. No reports, to the authors' knowledge, have described this complication following intensity modulated radiation therapy (IMRT) for oropharyngeal primaries. Once encountered, this adverse outcome can have serious impacts on speech and swallowing. We present here our institution's experience with delayed cranial neuropathies following primary radiation therapy for oropharyngeal squamous cell carcinoma, as well as document the only reported case following IMRT.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Virginia Commonwealth University, Richmond, Virginia 23298-0614, USA. athuang@mdanderson.org
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Huang
authors.forename: Shiyu
authors.initials: S
authors.lastname: Song
authors.forename: Laura M
authors.initials: LM
authors.lastname: Dominguez
authors.forename: Josephine
authors.initials: J
authors.lastname: Nguyen
authors.forename: Richard A
authors.initials: RA
authors.lastname: Goldman
authors.forename: Evan R
authors.initials: ER
authors.lastname: Reiter
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000532:radiotherapy*; D003389:Cranial Nerve Diseases / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology*; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects* / Q000379:methods; D014057:Tomography, X-Ray Computed