title: Preparation and double Michael addition reactions of a synthetic equivalent of the Nazarov reagent.
abstract: A synthetic equivalent of the Nazarov reagent, the silyl derivative 2, able to undergo base-catalyzed double Michael addition reactions with α,β-unsaturated carbonyl compounds has been developed. The new reagent satisfactorily reacts with unsaturated indolo[2,3-a]quinolizidine lactams to give pentacyclic yohimbinone-type derivatives.
authors.affiliation: Laboratory of Organic Chemistry, Faculty of Pharmacy, and Institute of Biomedicine (IBUB), University of Barcelona , 08028-Barcelona, Spain, and Institut de Ciència de Materials (CSIC) , Campus UAB, 08193-Cerdanyola, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Amat
authors.forename: Federica
authors.initials: F
authors.lastname: Arioli
authors.forename: Maria
authors.initials: M
authors.lastname: Pérez
authors.forename: Elies
authors.initials: E
authors.lastname: Molins
authors.forename: Joan
authors.initials: J
authors.lastname: Bosch
mesh_terms: D002384:Catalysis; D007202:Indicators and Reagents / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010421:Pentanoic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007202:Indicators and Reagents; D007211:Indoles; D007769:Lactams; D010421:Pentanoic Acids