title: Microenvironmental induced essentiality of autophagy.
abstract: Angiogenesis inhibitors cause increased hypoxia in tumors and this results in the induction of cytoprotective autophagy. Targeting this adaptation using autophagy inhibitors can overcome resistance to antiangiogenic therapy and enhance the antitumor effects.
authors.affiliation: Molecular Oncology Laboratories, Department of Oncology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
authors.forename: Dean C
authors.initials: DC
authors.lastname: Singleton
authors.forename: Adrian L
authors.initials: AL
authors.lastname: Harris
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001343:Autophagy / Q000187:drug effects*; D003110:Colonic Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents