title: In and out of the loop: external and internal modulation of the olivo-cerebellar loop.
abstract: Cerebellar anatomy is known for its crystal like structure, where neurons and connections are precisely and repeatedly organized with minor variations across the Cerebellar Cortex. The olivo-cerebellar loop, denoting the connections between the Cerebellar cortex, Inferior Olive and Cerebellar Nuclei (CN), is also modularly organized to form what is known as the cerebellar module. In contrast to the relatively organized and static anatomy, the cerebellum is innervated by a wide variety of neuromodulator carrying axons that are heterogeneously distributed along the olivo-cerebellar loop, providing heterogeneity to the static structure. In this manuscript we review modulatory processes in the olivo-cerebellar loop. We start by discussing the relationship between neuromodulators and the animal behavioral states. This is followed with an overview of the cerebellar neuromodulatory signals and a short discussion of why and when the cerebellar activity should be modulated. We then devote a section for three types of neurons where we briefly review its properties and propose possible neuromodulation scenarios.
authors.affiliation: Department of Neurobiology, Life Science Institute, Hebrew University Jerusalem, Israel ; Edmund and Lily Safra Center for Brain Sciences, Hebrew University Jerusalem, Israel.
authors.forename: Avraham M
authors.initials: AM
authors.lastname: Libster
authors.forename: Yosef
authors.initials: Y
authors.lastname: Yarom
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002525:Cerebellar Cortex / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology; D006801:Humans; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009847:Olivary Nucleus / Q000502:physiology*
keywords: aminergic modulation; cerebellar cortex; cerebellar nuclei; cerebellum; inferior olive; neuromodulation; olivo-cerebellar loop