title: [Hypokalemic myopathy with severe constipation in a patient routinely administered sodium polystyrene sulfonate and the spherical carbon adsorbent].
abstract: 66-year-old man was hospitalized because of severe abdominal pain. He had been treated for chronic renal failure. Sodium polystyrene sulfonate (SPS) and the spherical carbon adsorbent AST-120 were routinely administered to him. However, after several treatments, his pain did not resolve and his serum creatine kinase concentration was markedly elevated, so he was transferred to our hospital. Before admission to the previous hospital, muscular weakness was noted in his extremities and those symptoms persisted. His serum potassium concentration was 1.6 mEq/L, and he was administered potassium. A lower gastrointestinal endoscopy revealed normal mucosa and SPS powder-like brownish-yellow stool containing AST-120 granules in the colorectum. After massive stool discharge, the patient's pain improved and his serum potassium concentration gradually increased. The patient was diagnosed with hypokalemic myopathy thought to be mainly caused by accumulation of SPS in the colorectum.
authors.affiliation: Department of Critical Care Medicine, Iwate Medical University.
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Fujino
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Inoue
authors.forename: Makoto
authors.initials: M
authors.lastname: Onodera
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Tatsuyori
authors.initials: T
authors.lastname: Shozushima
authors.forename: Shigeatsu
authors.initials: S
authors.lastname: Endo
authors.forename: Yuji
authors.initials: Y
authors.lastname: Fujita
mesh_terms: D002244:Carbon / Q000009:adverse effects*; D003248:Constipation / Q000139:chemically induced* / Q000628:therapy; D003672:Defecation; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D010087:Oxides / Q000009:adverse effects*; D011137:Polystyrenes / Q000009:adverse effects*; D011188:Potassium / Q000008:administration & dosage; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D010087:Oxides; D011137:Polystyrenes; C003321:polystyrene sulfonic acid; D002244:Carbon; C040896:AST 120; D011188:Potassium