title: Oxidative stress is not involved in motion sickness in mice.
abstract: OBJECTIVE
  Some indirect evidences indicate a possible correlation between oxidative stress and motion sickness. The aim of this research was to investigate whether oxidative stress contributing to motion sickness in mice or not.
  
  
  METHODS
  We examined the mRNA levels of peroxiredoxin 6 (PRDX6), catalase, and enzyme superoxide dismutase 1 (SOD1); reactive oxygen species (ROS); and total antioxidant capacity and SOD activity in different brain regions after rotary stimulation. Mice motion sickness index was recorded after rotation when pretreated with paraquat, vitamin C, or vitamin E.
  
  
  RESULTS
  The ROS level and antioxidant capacity were both increased in cerebellum plus brainstem (CB) after rotation, a critical region determines motion sickness. However, manipulation of oxidants or antioxidants using pharmacological method in vivo had no influence on motion sickness index in mice.
  
  
  CONCLUSIONS
  Oxidative stress is not involved in the development of motion sickness in mice.
authors.affiliation: Department of Pharmacology, Second Military Medical University, Shanghai, China.
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Han
authors.forename: Ye
authors.initials: Y
authors.lastname: Tu
authors.forename: Wei-Ye
authors.initials: WY
authors.lastname: Liu
authors.forename: Bei-Lei
authors.initials: BL
authors.lastname: Tao
authors.forename: Li-Chao
authors.initials: LC
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Li
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009041:Motion Sickness / Q000188:drug therapy / Q000503:physiopathology*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species
keywords: Mice; Motion sickness; Oxidative stress