title: Role of insulin resistance and diet in acne.
abstract: There is increasing evidence in support of the interplay of growth hormone (GH), insulin, and insulin-like growth factor-1 (IGF-1) signaling during puberty, which have a causal role in pathogenesis of acne by influencing adrenal and gonadal androgen metabolism. Milk consumption and hyperglycemic diets can induce insulin and IGF-1-mediated PI3K ⁄ Akt-activation inducing sebaceous lipogenesis, sebocyte, and keratinocyte proliferation, which can aggravate acne. Occurence of acne as part of various syndromes also provides evidence in favor of correlation between IGF-1 and acne.
authors.affiliation: Department of Dermatology and STD, JIPMER, Pondicherry, India.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Kumari
authors.forename: Devinder Mohan
authors.initials: DM
authors.lastname: Thappa
mesh_terms: D000152:Acne Vulgaris / Q000178:diet therapy* / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy* / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D050155:Lipogenesis / Q000502:physiology*