title: Highly chemo- and enantioselective cross-benzoin reaction of aliphatic aldehydes and α-ketoesters.
abstract: An electron-deficient, valine-derived triazolium salt is shown to catalyze a highly chemo- and enantioselective cross-benzoin reaction between aliphatic aldehydes and α-ketoesters. This methodology represents the first high yielding and highly enantioselective intermolecular cross-benzoin reaction using an organocatalyst (up to 94% ee). Further diastereoselective reduction of the products gives access to densely oxygenated compounds with high chemo- and diastereoselectivity.
authors.affiliation: Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
authors.forename: Karen
authors.initials: K
authors.lastname: Thai
authors.forename: Steven M
authors.initials: SM
authors.lastname: Langdon
authors.forename: François
authors.initials: F
authors.lastname: Bilodeau
authors.forename: Michel
authors.initials: M
authors.lastname: Gravel