title: Cancer risk in Lynch Syndrome.
abstract: Lynch Syndrome, or hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by inactivating mutations in DNA mismatch repair genes. It accounts for 2-4 % of all incident colorectal cancers. Mutation carriers are at risk of early onset colorectal cancer, endometrial cancer, and a spectrum of other tumours. Accurate estimation of cancer risk for mutation carriers is essential for counselling, and establishing appropriate screening guidelines. This study reviews the current data on cancer risk, and emerging risk reduction strategies.
authors.affiliation: Department of General Surgery, University of Manchester and Central Manchester University Hospitals NHS Foundation Trust, Manchester Royal Infirmary, Oxford Road, Manchester, UK. emma.barrow@doctors.org.uk
authors.forename: Emma
authors.initials: E
authors.lastname: Barrow
authors.forename: James
authors.initials: J
authors.lastname: Hill
authors.forename: D Gareth
authors.initials: DG
authors.lastname: Evans
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications* / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors