title: The long pentraxin PTX3: a candidate anti-inflammatory mediator in cardiac surgery.
abstract: Coronary artery bypass grafting (CABG) is performed with the use of cardiopulmonary bypass (CPB) and cardioplegic arrest (CA) of the heart. The advantage of this technique, alternatively referred to as "on-pump" surgery, resides, for the surgeon, in relatively easy access to and manipulation with the non-beating, bloodless heart. However, the advantage that is, thereby, gained by the patient is paid off by an increased susceptibility to postoperative systemic inflammatory response syndrome (SIRS). Under unfavorable conditions, the inflammatory syndrome may develop into life-threatening forms of MODS (multiple organ dysfunction syndrome) or even MOFS (multiple organ failure syndrome). Deliberate avoidance of CPB, also known as "off-pump" surgery, attenuates early postoperative inflammation throughout its trajectory of SIRS→MODS→MOFS, but, in the long run, there appears to be no substantial difference in the overall mortality rates. In the last years, our knowledge of the pathophysiology of surgical inflammation has increased considerably. Recent findings, highlighting the as yet rather obscure role of pentraxin 3 (PTX3) in these processes, are discussed in this review article.
authors.affiliation: Deparment of Cardiac Surgery, Charles University in Prague, Medical School and University Hospital in Hradec Kralove, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Kunes
authors.forename: J
authors.initials: J
authors.lastname: Mandak
authors.forename: Z
authors.initials: Z
authors.lastname: Holubcova
authors.forename: M
authors.initials: M
authors.lastname: Kolackova
authors.forename: J
authors.initials: J
authors.lastname: Krejsek
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000276:immunology*; D050197:Atherosclerosis / Q000276:immunology; D002097:C-Reactive Protein / Q000235:genetics / Q000276:immunology*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects* / Q000379:methods; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods; D006324:Heart Arrest, Induced / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology; D009203:Myocardial Infarction / Q000276:immunology; D000683:Serum Amyloid P-Component / Q000235:genetics / Q000276:immunology*; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D059467:Transcriptome; D000099153:Pentraxins
chemical_list: D000893:Anti-Inflammatory Agents; D002097:C-Reactive Protein; D016753:Interleukin-10; D000683:Serum Amyloid P-Component; D000099153:Pentraxins
keywords: alarmins; cardiopulmonary bypass; coronary artery bypass grafting; interleukin-10; pentraxin 3; sterile inflammation