title: Glutamine protects mice from acute graft-versus-host disease (aGVHD).
abstract: Despite current immunosuppressive therapies, acute graft-versus-host disease (aGVHD) is a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (HSCT). In the present study, therapeutic effects of intraperitoneal glutamine (Gln) administration (1g/kg/day) in a mouse aGVHD model were evaluated. Gln administration significantly inhibited the GVHD-induced inflammation and tissue injury in the intestine, liver, skin and spleen. Gln therapy improved the score of clinical evidence of aGVHD and prolonged the median survival of aGVHD mice. Gln administration in aGVHD mice increased the fraction of Foxp3+/CD4+/CD25+ cells in the blood measured on day 7, and decreased the serum levels of tumor necrosis factor-α measured on days 7, 14 and 21 after aGVHD induction. These results demonstrated that Gln administration may be useful in protecting the host from aGVHD.
authors.affiliation: Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-180, Republic of Korea.
authors.forename: Eun-Kee
authors.initials: EK
authors.lastname: Song
authors.forename: Jun-Mo
authors.initials: JM
authors.lastname: Yim
authors.forename: Joo-Yun
authors.initials: JY
authors.lastname: Yim
authors.forename: Min-Young
authors.initials: MY
authors.lastname: Song
authors.forename: Hye-Won
authors.initials: HW
authors.lastname: Rho
authors.forename: Sung Kyun
authors.initials: SK
authors.lastname: Yim
authors.forename: Yeon-Hee
authors.initials: YH
authors.lastname: Han
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Jeon
authors.forename: Hee Sun
authors.initials: HS
authors.lastname: Kim
authors.forename: Ho-Young
authors.initials: HY
authors.lastname: Yhim
authors.forename: Na-Ri
authors.initials: NR
authors.lastname: Lee
authors.forename: Jae-Yong
authors.initials: JY
authors.lastname: Kwak
authors.forename: Myung-Hee
authors.initials: MH
authors.lastname: Sohn
authors.forename: Ho Sung
authors.initials: HS
authors.lastname: Park
authors.forename: Kyu Yun
authors.initials: KY
authors.lastname: Jang
authors.forename: Chang-Yeol
authors.initials: CY
authors.lastname: Yim
mesh_terms: D000208:Acute Disease; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D017690:Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D005260:Female; D051858:Forkhead Transcription Factors / Q000097:blood; D005973:Glutamine / Q000008:administration & dosage / Q000494:pharmacology*; D006086:Graft vs Host Disease / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D007249:Inflammation / Q000517:prevention & control; D007274:Injections, Intraperitoneal; D007371:Interferon-gamma / Q000097:blood; D053645:Interleukin-2 Receptor alpha Subunit / Q000097:blood; D007422:Intestines / Q000187:drug effects / Q000473:pathology; D007958:Leukocyte Count; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013154:Spleen / Q000166:cytology*; D016019:Survival Analysis; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; C508018:Il2ra protein, mouse; D053645:Interleukin-2 Receptor alpha Subunit; D014409:Tumor Necrosis Factor-alpha; D005973:Glutamine; D007371:Interferon-gamma