title: Transcription factor STAT1 gene polymorphism is associated with the development of severe forms of periodontal disease.
abstract: BACKGROUND
  Periodontal disease (PD) is one of the most common inflammatory diseases, affecting about 10 % of the world population. The establishment of PD is influenced by polymorphisms in genes involved with the inflammatory response. Signal Transducer and Activator of Transcription (STAT)-1 is a transcription factor that plays a key role in the intracellular signaling triggered by cytokines and, thus, its activation is critical in inflammatory diseases.
  
  
  OBJECTIVE
  We aim to evaluate the occurrence of association between STAT-1 (rs3771300) polymorphism and distinct clinical forms and severity of PD; we genotyped 180 subjects using realtime PCR.
  
  
  CONCLUSIONS
  We observed that the presence of the G allele for STAT-1 was associated with twice as high of a chance to develop aggressive periodontitis, and the most severe form of the disease.
authors.affiliation: Laboratório de Biologia das Interações Celulares, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Pampulha, Belo Horizonte, MG CEP 31270-901, Brazil.
authors.forename: Adriana Machado
authors.initials: AM
authors.lastname: Saraiva
authors.forename: Jeane
authors.initials: J
authors.lastname: de Fátima Correia Silva
authors.forename: Micena Roberta Miranda
authors.initials: MR
authors.lastname: Alves e Silva
authors.forename: José Eustáquio
authors.initials: JE
authors.lastname: da Costa
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Gollob
authors.forename: Paula Rocha
authors.initials: PR
authors.lastname: Moreira
authors.forename: Walderez Ornelas
authors.initials: WO
authors.lastname: Dutra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D010520:Aggressive Periodontitis / Q000453:epidemiology / Q000235:genetics*; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D050794:STAT1 Transcription Factor / Q000235:genetics*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human