title: Reinforcement of a new calcium phosphate cement with RGD-chitosan-fiber.
abstract: Calcium phosphate cement (CPC) has been widely used in orthopedic and dental applications. A critical limitation of CPC is low strength and high susceptibility to severe fracture. Surgeons can use it only to reconstruct non-stress bearing bone, raising the need for a tougher new generation of CPC. Fibers have been used as a reinforcement of CPC to improve the strength of a pure CPC scaffold. The RGD peptides (Arg-Gly-Asp) have been used to improve the biocompatibility of the scaffold, via physical adsorption. The purpose of this study was to develop a novel CPC scaffold reinforced by RGD peptide-bearing chitosan fibers (RGD-fiber-CPC). Our data showed that the RGD-fiber-CPC scaffold had an increased flexural strength, and stimulated new bone formation in an animal model. The RGD-fiber-CPC is a novel bone graft substitute in orthopedic surgery.
authors.affiliation: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200011, China; Department of Orthopaedic Surgery, 2nd Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210011, China.
authors.forename: Tian-Yi
authors.initials: TY
authors.lastname: Wu
authors.forename: Zu-Bin
authors.initials: ZB
authors.lastname: Zhou
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: He
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Ren
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Yu
authors.forename: Ye
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology; D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology; D003738:Dental Cements / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology; D010012:Osteogenesis / Q000187:drug effects*
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D003738:Dental Cements; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid; D048271:Chitosan; C020243:calcium phosphate
keywords: CPC bone cement; RGD; biocompatibility; reinforcement