title: Intracranial tuberculoma in non-immunosuppressive state.
abstract: The rise in the incidence of tuberculosis is generally related to human immunodeficiency virus infection. However, intracranial tuberculoma, a complication of tuberculosis considered to be a critical disease, can develop even in the absence of immunosuppressive state. Here, we describe 2 cases of intracranial tuberculoma occurring in patients with no evidence of immunosuppressive state or past history of tuberculosis. In Case 1, lesions were observed in the right lateral ventricle, with histological examination revealing granulomatous lesions. In Case 2, scattered lesions were observed in the cranium and the lung fields. In both cases, the QuantiFERON Test (QFT) was positive, and improvements were observed in the symptoms following administration of antituberculous drugs. Intracranial tuberculoma cannot be considered rare, and needs to be included in the differential diagnosis of intracranial lesions. Diagnosis can be tricky since this disease can develop in a patient in a non-immunosuppressive state or without a past history of tuberculosis. The QFT is an effective test to enable the diagnosis of tuberculomas in atypical patients.
authors.affiliation: Department of Neurosurgery, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Aikawa
authors.forename: Sumito
authors.initials: S
authors.lastname: Narita
authors.forename: Masanori
authors.initials: M
authors.lastname: Tsutsumi
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yoshida
authors.forename: Housei
authors.initials: H
authors.lastname: Etou
authors.forename: Kimiya
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Ritsuro
authors.initials: R
authors.lastname: Inoue
authors.forename: Kohei
authors.initials: K
authors.lastname: Nii
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kazekawa
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007089:Image Enhancement; D007090:Image Interpretation, Computer-Assisted; D007121:Immunocompetence / Q000276:immunology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination; D016862:Tuberculoma, Intracranial / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology
chemical_list: D000995:Antitubercular Agents