title: Regulation of the thermal sensitivity of hydroxypropyl cellulose by poly(N-isopropylacryamide) side chains.
abstract: Hydroxyproyl cellulose graft poly(N-isopropylacryamide) (HPC-g-PNIPAm) copolymers were synthesized by single-electron transfer living radical polymerization (SET-LRP) in water and THF mixture solvent and characterized. The controllability and polymerization rate of SET-LRP can be adjusted by the water/THF ratio in the mixture solvent. The monomer conversion rate is relatively low in the solvent with low water content. The thermal responsive property of HPC-g-PNIPAm copolymers in aqueous solution depends on the length of the graft chains. The relatively short PNIPAm side chains (<150 repeat units) can effectively regulate the low critical solution temperature (LCST) of the HPC-g-PNIPAm copolymers in aqueous solution due to the hydrophilic properties of the short PNIPAm chains. This work provides an approach for the regulation of the LCST to body temperature region by graft copolymerization.
authors.affiliation: Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
authors.forename: Hongliang
authors.initials: H
authors.lastname: Kang
authors.forename: Ruigang
authors.initials: R
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D001831:Body Temperature; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D005663:Furans; D012997:Solvents; D014867:Water; C052970:poly-N-isopropylacrylamide; C018674:tetrahydrofuran; D002482:Cellulose; C008079:hydroxypropylcellulose