title: Design, synthesis and antimicrobial activities of some azole derivatives.
abstract: Three new 1,3,4-oxadiazole, 1,3-thiazolidine and 1,2,4-triazole derivatives were obtained starting from furan-2-carbohydrazide. Then, 1,2,4-triazole compound was converted to the corresponding Mannich bases using several secondary amines including piperidine, piperazine, morpholine or thiomorpholine moiety. The synthesis of 5-(furan-2-yl)-4-{[(4-methoxyphenyl)methylidene]amino}-4H-1,2,4-triazole-3-thiol (XIII) was performed starting from furan-2-carbohydrazide by three steps. The structures of the synthesized compounds were well characterized by elemental analyses, IR, 1H NMR, 13C NMR and mass spectral studies. Newly synthesized compounds were screened for their antimicrobial activities and some of them displayed activity against the tested microorganisms.
authors.affiliation: Karadeniz Technical University, Department of Chemistry, 61080 Trabzon, Turkey.
authors.forename: Serap
authors.initials: S
authors.lastname: Basoglu
authors.forename: Meltem
authors.initials: M
authors.lastname: Yolal
authors.forename: Serpil
authors.initials: S
authors.lastname: Demirci
authors.forename: Neslihan
authors.initials: N
authors.lastname: Demirbas
authors.forename: Hakan
authors.initials: H
authors.lastname: Bektas
authors.forename: Sengul Alpay
authors.initials: SA
authors.lastname: Karaoglu
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001393:Azoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D008352:Mannich Bases / Q000138:chemical synthesis / Q000494:pharmacology; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D001393:Azoles; D008352:Mannich Bases