title: Implications of the histological determination of microRNAs in the screening, diagnosis and prognosis of colorectal cancer.
abstract: MicroRNAs are short non-coding RNA molecules that participate in the regulation of gene expression. Several studies have demonstrated the involvement of microRNAs in oncogenesis and a variety of physiological functions. We conducted a literature review of studies that evaluated histological microRNAs in colorectal cancer. Although additional clinical studies are required to substantiate the relationship between microRNAs and colorectal cancer, there is preliminary evidence that microRNAs are related to the diagnosis and prognosis of colorectal cancer.
authors.affiliation: Department of General Surgery, Gutiérrez Ortega Hospital, Ciudad Real, Spain. pablomensan@hotmail.com
authors.forename: Pablo
authors.initials: P
authors.lastname: Menéndez
authors.forename: Pedro
authors.initials: P
authors.lastname: Villarejo
authors.forename: David
authors.initials: D
authors.lastname: Padilla
authors.forename: José María
authors.initials: JM
authors.lastname: Menéndez
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Rodríguez-Montes
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D055088:Early Detection of Cancer; D005243:Feces / Q000737:chemistry; D006801:Humans; D008403:Mass Screening; D035683:MicroRNAs / Q000378:metabolism*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs