title: The risk of falls on initiation of antihypertensive drugs in the elderly.
abstract: CONCLUSIONS
  Antihypertensive drugs are associated with an immediate increased falls risk in elderly patients which was significant during the first 14 days after receiving a thiazide diuretic, angiotensin-converting enzyme inhibitor, angiotensin II receptor blocker, calcium channel blocker, or beta-adrenergic blocker. Fall prevention strategies during this period may prevent fall-related injuries.
  
  
  BACKGROUND
  The purpose of this study is to evaluate if initiation of the common antihypertensive drugs is associated with the occurrence of falls.
  
  
  METHODS
  This population-based self-controlled case series study used healthcare administrative databases to identify new users of antihypertensive drugs in the elderly aged 66 and older living in Ontario, Canada who suffered a fall from April 1, 2000 to March 31, 2009. The risk period was the first 45 days following antihypertensive therapy initiation, further subdivided into 0-14 and 15-44 days with control periods before and after treatment in a 450-day observation period. We calculated the relative incidence (incidence rate ratio, IRR), defined as the rate of falls in the risk period compared to falls rate in the control periods.
  
  
  RESULTS
  Of the 543,572 new users of antihypertensive drugs among community-dwelling elderly, 8,893 experienced an injurious fall that required hospital care during the observation period. New users had a 69 % increased risk of having an injurious fall during the first 45 days following antihypertensive treatment (IRR = 1.69; 95 % CI, 1.57-1.81). This finding was consistent for thiazide diuretics, angiotensin-converting enzyme inhibitors, calcium channel blockers, and beta-adrenergic blockers but not angiotensin II receptor antagonists. There was also an increased falls risk during the first 14 days of antihypertensive drug initiation (IRR = 1.94; 95 % CI, 1.75-2.16), which was consistent for all antihypertensive drug classes.
  
  
  CONCLUSIONS
  This study suggests that initiation of antihypertensive drugs is a risk factor for falls in the elderly. Fall prevention strategies during this period may reduce injuries.
authors.affiliation: Department of Family and Community Medicine, The Scarborough Hospital, University of Toronto, Toronto, Ontario, Canada, debra.butt@utoronto.ca.
authors.forename: D A
authors.initials: DA
authors.lastname: Butt
authors.forename: M
authors.initials: M
authors.lastname: Mamdani
authors.forename: P C
authors.initials: PC
authors.lastname: Austin
authors.forename: K
authors.initials: K
authors.lastname: Tu
authors.forename: T
authors.initials: T
authors.lastname: Gomes
authors.forename: R H
authors.initials: RH
authors.lastname: Glazier
mesh_terms: D000058:Accidental Falls / Q000517:prevention & control / Q000706:statistics & numerical data*; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000009:adverse effects*; D016208:Databases, Factual; D011307:Drug Prescriptions; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009864:Ontario / Q000453:epidemiology; D018570:Risk Assessment / Q000379:methods; D014947:Wounds and Injuries / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control
chemical_list: D000959:Antihypertensive Agents