title: [Multiple neoplasms in gastric cancer patients: patterns of development, results of treatment].
abstract: Patterns of polyneoplasia development were analyzed in radically operated gastric cancer patients. The second tumors were revealed in 99 of 1255 patients (7,9%) as soon as patients with early gastric cancer manifested primary-multiple malignant tumors almost two times more (15,4%). Among second tumors there were predominantly tumors of the colon, urogenital system, head and neck and also lymphoproliferative diseases. Along with tumors prior to the diagnosis "gastric cancer" there were met mostly lymphoproliferative diseases and breast cancer; of synchronous--cancer of the colon and bladder; among exposed after treatment of gastric cancer-cancer of the colon, pancreas, and skin. Radical surgery because of the second tumor was provided to 77,6% patients, palliative surgery--to 12,6%. In the treatment of second tumors there were most commonly used surgical technique--in 40 (39%) patients, radiotherapy +/- chemotherapy--in 27 (26%), the combined method (surgery+radiotherapy/chemotherapy)--in 22 (21%). Second tumors (both synchronous and metachronous) were the main cause of death of patients. Thus, the occurrence of a second tumor in patients with gastric cancer is constantly increasing the frequency of the event, with the possibility of early detection and curative treatment of synchronous and especially metachronous tumors determine the prognosis in this group of patients. Primary tumor multiplicity is not a contraindication both to a radical, including combined, and palliative treatment of each of the tumors.
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Skoropad
authors.forename: B A
authors.initials: BA
authors.lastname: Bedrov
authors.forename: G O
authors.initials: GO
authors.lastname: Rukhadze
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000453:epidemiology; D055088:Early Detection of Cancer; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000453:epidemiology; D018714:Radiotherapy, Adjuvant; D012878:Skin Neoplasms / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000601:surgery*; D014565:Urogenital Neoplasms / Q000453:epidemiology