title: Risk factors for hepatitis C transmission in HIV patients, Hepacam study, ANRS 12267 Cambodia.
abstract: In 2009, we conducted a case-control study to explore the routes of HCV transmission in people living with HIV/AIDS (PLHIV) in Cambodia. Cases were HCV/HIV co-infected patients (who tested RT-PCR positive for HCV-RNA or had confirmed presence of HCV antibodies) (n = 44). Controls were HIV mono-infected patients, with no HCV antibodies (n = 160). They were recruited among the PLHIV presenting at one national reference centre of HIV/AIDS. Multivariate analysis showed that factors associated with the co-infection were the age older than 50 years (OR 5.4, 95 % confidence interval (CI) 1.5-19.6), the exposure to multiple parenteral infusions before the year 2000 (OR 3.4, 95 % CI 1.5-7.6), to surgery (OR 2.6, 95 % CI 1.2-5.7) and to fibroscopy (OR 2.4, 95 % CI 1.0-5.7). These results show the need to implement HCV screening in PLHIV, to support the implementation of national infection control guidelines, and to reinforce public awareness on the risks linked to parenteral medications.
authors.affiliation: Epidemiology and Public Health Unit, Pasteur Institute in Cambodia, 5, Boulevard Monivong, BP 983, Phnom Penh, Cambodia, sophiegoyet@gmail.com.
authors.forename: Sophie
authors.initials: S
authors.lastname: Goyet
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lerolle
authors.forename: Isabelle
authors.initials: I
authors.lastname: Fournier-Nicolle
authors.forename: Sreymom
authors.initials: S
authors.lastname: Ken
authors.forename: Janin
authors.initials: J
authors.lastname: Nouhin
authors.forename: Ly
authors.initials: L
authors.lastname: Sowath
authors.forename: Hubert
authors.initials: H
authors.lastname: Barennes
authors.forename: Chanroeurn
authors.initials: C
authors.lastname: Hak
authors.forename: Chakravuth
authors.initials: C
authors.lastname: Ung
authors.forename: Gérald
authors.initials: G
authors.lastname: Viretto
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Delfraissy
authors.forename: Pichit
authors.initials: P
authors.lastname: Khuon
authors.forename: Olivier
authors.initials: O
authors.lastname: Segeral
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D002160:Cambodia / Q000453:epidemiology; D016022:Case-Control Studies; D060085:Coinfection / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology*; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors
chemical_list: D044966:Anti-Retroviral Agents