title: Synthesis and antiviral evalution of some novel pyrazoles and pyrazolo[3,4-d]pyridazines bearing 5,6,7,8-tetrahydronaphthalene.
abstract: The enaminone 2 was reacted with hydrazonyl halides 3a-d to afford the corresponding pyrazole derivatives (6a-d) which reacted with hydrazine hydrate to afford the new pyrazolo[3,4-d]pyridazine derivatives 7a-d, respectively. In addition, compound 2 was reacted with some primary aromatic amines to afford the corresponding secondary enaminones 10a-c and reacted with sulfapyridine or sulfapyrimidine to afford the corresponding sulfonamide derivatives 12a and 12b. Evaluation of these new compounds against rotavirus Wa strain and adenovirus type 7 showed promising antiviral activity.
authors.affiliation: Applied Organic Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt. dmehalhamdy63@hotmail.com
authors.forename: Nehal A
authors.initials: NA
authors.lastname: Hamdy
authors.forename: Waled M
authors.initials: WM
authors.lastname: El-Senousy
mesh_terms: D000256:Adenoviridae / Q000187:drug effects / Q000254:growth & development; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012401:Rotavirus / Q000187:drug effects / Q000254:growth & development; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D011720:Pyrazoles; D011724:Pyridazines; D013764:Tetrahydronaphthalenes