title: Interactive, multi-modality image registrations for combined MRI/MRSI-planned HDR prostate brachytherapy.
abstract: This study presents the steps and criteria involved in the series of image registrations used clinically during the planning and dose delivery of focal high dose-rate (HDR) brachytherapy of the prostate.
  
  
  
  Three imaging modalities - Magnetic Resonance Imaging (MRI), Magnetic Resonance Spectroscopic Imaging (MRSI), and Computed Tomography (CT) - were used at different steps during the process. MRSI is used for identification of dominant intraprosatic lesions (DIL). A series of rigid and nonrigid transformations were applied to the data to correct for endorectal-coil-induced deformations and for alignment with the planning CT. Mutual information was calculated as a morphing metric. An inverse planning optimization algorithm was applied to boost dose to the DIL while providing protection to the urethra, penile bulb, rectum, and bladder. Six prostate cancer patients were treated using this protocol.
  
  
  
  The morphing algorithm successfully modeled the probe-induced prostatic distortion. Mutual information calculated between the morphed images and images acquired without the endorectal probe showed a significant (p= 0.0071) increase to that calculated between the unmorphed images and images acquired without the endorectal probe. Both mutual information and visual inspection serve as effective diagnostics of image morphing. The entire procedure adds less than thirty minutes to the treatment planning.
  
  
  
  This work demonstrates the utility of image transformations and registrations to HDR brachytherapy of prostate cancer.
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA.
authors.forename: Galen
authors.initials: G
authors.lastname: Reed
authors.forename: J Adam
authors.initials: JA
authors.lastname: Cunha
authors.forename: Susan
authors.initials: S
authors.lastname: Noworolski
authors.forename: John
authors.initials: J
authors.lastname: Kurhanewicz
authors.forename: Daniel
authors.initials: D
authors.lastname: Vigneron
authors.forename: I-Chow
authors.initials: IC
authors.lastname: Hsu
authors.forename: Jean
authors.initials: J
authors.lastname: Pouliot
keywords: HDR; MRSI; image registration; prostate