title: The clinical significance of mesenchyme forkhead 1 (FoxC2) in gastric carcinoma.
abstract: OBJECTIVE
  Mesenchyme forkhead 1 (FoxC2) is an epithelial-mesenchymal transition (EMT)-inducing factor. Previous studies have demonstrated that FoxC2 binds directly to the promoter region of p120-catenin (p120ctn). The aim of this study was to investigate the clinical significance of FoxC2 expression and the inter-relationship between FoxC2 and p120ctn, in gastric cancer.
  
  
  RESULTS
  Immunohistochemistry was used to examine the expression of FoxC2 and p120ctn proteins in 325 gastric cancer samples. Staining for FoxC2 in cancer tissues was markedly stronger than in normal tissues. High FoxC2 expression was associated significantly with differentiation, invasion depth, lymph node metastasis and tumour stage. Patients with high FoxC2 expression or low p120ctn expression had a poor prognosis. In the high p120ctn expression group, the prognosis for patients with low FoxC2 expression was better than for the high FoxC2 group. Moreover, stepwise Cox regression showed that p120ctn was an independent prognostic factor, but FoxC2 in combination with p120ctn was not correlated significantly with survival.
  
  
  CONCLUSIONS
  We found that FoxC2 and p120ctn play important roles in the progression and prognosis of gastric cancer. Moreover, FoxC2 and p120ctn should be evaluated further as novel biomarkers and therapeutic targets for gastric cancer treatment.
authors.affiliation: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, China.
authors.forename: Jin-Liang
authors.initials: JL
authors.lastname: Zhu
authors.forename: Yong-Xi
authors.initials: YX
authors.lastname: Song
authors.forename: Zhen-Ning
authors.initials: ZN
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Gao
authors.forename: Mei-Xian
authors.initials: MX
authors.lastname: Wang
authors.forename: Yu-Lan
authors.initials: YL
authors.lastname: Dong
authors.forename: Cheng-Zhong
authors.initials: CZ
authors.lastname: Xing
authors.forename: Hui-Mian
authors.initials: HM
authors.lastname: Xu
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000401:mortality / Q000556:secondary*; D014408:Biomarkers, Tumor / Q000378:metabolism; D051177:Catenins / Q000378:metabolism; D002681:China / Q000453:epidemiology; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D000095002:Delta Catenin
chemical_list: D014408:Biomarkers, Tumor; D051177:Catenins; D051858:Forkhead Transcription Factors; C082078:mesenchyme fork head 1 protein; D000095002:Delta Catenin; C000722347:CTNND1 protein, human