title: The normal limits, subclinical significance, related metabolic derangements and distinct biological effects of body site-specific adiposity in relatively healthy population.
abstract: BACKGROUND
  The accumulation of visceral adipose tissue that occurs with normal aging is associated with increased cardiovascular risks. However, the clinical significance, biological effects, and related cardiometabolic derangements of body-site specific adiposity in a relatively healthy population have not been well characterized.
  
  
  METHODS
  In this cross-sectional study, we consecutively enrolled 608 asymptomatic subjects (mean age: 47.3 years, 27% female) from 2050 subjects undergoing an annual health survey in Taiwan. We measured pericardial (PCF) and thoracic peri-aortic (TAT) adipose tissue volumes by 16-slice multi-detector computed tomography (MDCT) (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, USA) and related these to clinical characteristics, body fat composition (Tanita 305 Corporation, Tokyo, Japan), coronary calcium score (CCS), serum insulin, high-sensitivity C-reactive protein (Hs-CRP) level and circulating leukocytes count. Metabolic risk was scored by Adult Treatment Panel III guidelines.
  
  
  RESULTS
  TAT, PCF, and total body fat composition all increased with aging and higher metabolic scores (all p<0.05). Only TAT, however, was associated with higher circulating leukocyte counts (ß-coef.:0.24, p<0.05), serum insulin (ß-coef.:0.17, p<0.05) and high sensitivity C-reactive protein (ß-coef.:0.24, p<0.05). These relationships persisted after adjustment in multivariable models (all p<0.05). A TAT volume of 8.29 ml yielded the largest area under the receiver operating characteristic curve (AUROC: 0.79, 95%CI: 0.74-0.83) to identify metabolic syndrome. TAT but not PCF correlated with higher coronary calcium score after adjustment for clinical variables (all p<0.05).
  
  
  CONCLUSIONS
  In our study, we observe that age-related body-site specific accumulation of adipose tissue may have distinct biological effects. Compared to other adiposity measures, peri-aortic adiposity is more tightly associated with cardiometabolic risk profiles and subclinical atherosclerosis in a relatively healthy population.
authors.affiliation: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan.
authors.forename: Chun-Ho
authors.initials: CH
authors.lastname: Yun
authors.forename: Hiram G
authors.initials: HG
authors.lastname: Bezerra
authors.forename: Tung-Hsin
authors.initials: TH
authors.lastname: Wu
authors.forename: Fei-Shih
authors.initials: FS
authors.lastname: Yang
authors.forename: Chuan-Chuan
authors.initials: CC
authors.lastname: Liu
authors.forename: Yih-Jer
authors.initials: YJ
authors.lastname: Wu
authors.forename: Jen-Yuan
authors.initials: JY
authors.lastname: Kuo
authors.forename: Chung-Lieh
authors.initials: CL
authors.lastname: Hung
authors.forename: Jason Jeun-Shenn
authors.initials: JJ
authors.lastname: Lee
authors.forename: Charles Jia-Yin
authors.initials: CJ
authors.lastname: Hou
authors.forename: Hung-I
authors.initials: HI
authors.lastname: Yeh
authors.forename: Chris T
authors.initials: CT
authors.lastname: Longenecker
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Cury
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D050154:Adiposity; D000886:Anthropometry; D001011:Aorta / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D006262:Health; D006801:Humans; D007249:Inflammation; D007328:Insulin / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000473:pathology*; D008875:Middle Aged; D016017:Odds Ratio; D009929:Organ Size; D010496:Pericardium / Q000473:pathology; D012372:ROC Curve; D012016:Reference Values
chemical_list: D015415:Biomarkers; D007328:Insulin; D002097:C-Reactive Protein; D002118:Calcium