title: Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories.
abstract: The neocortex is thought to be a distributed learning system that gradually integrates semantic information into the initial mnemonic representation rapidly formed by the hippocampus after acquisition. Nevertheless, an emerging view suggests that some cortical regions, in particular the medial prefrontal cortex (mPFC), may also have a role during the initial steps of memory consolidation as well as in the recall of recent memories. Here, we show that mPFC plays a critical role during the first few hours of inhibitory avoidance memory consolidation and is necessary for the normal retrieval of both recent and remote memories, supporting the idea that involvement of neocortical areas in memory processing is not restricted to the late post-training consolidation phase.
authors.affiliation: Instituto de Biología Celular y Neurociencias, Facultad de Medicina, UBA, Paraguay 2155, 3° piso, 1121 ABG Buenos Aires, Argentina.
authors.forename: Carolina
authors.initials: C
authors.lastname: Gonzalez
authors.forename: Cecilia
authors.initials: C
authors.lastname: Kramar
authors.forename: Fernando
authors.initials: F
authors.lastname: Garagoli
authors.forename: Janine I
authors.initials: JI
authors.lastname: Rossato
authors.forename: Noelia
authors.initials: N
authors.lastname: Weisstaub
authors.forename: Martín
authors.initials: M
authors.lastname: Cammarota
authors.forename: Jorge H
authors.initials: JH
authors.lastname: Medina
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D004640:Emetine / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D009118:Muscimol / Q000494:pharmacology; D009415:Nerve Net / Q000187:drug effects / Q000502:physiology*; D017397:Prefrontal Cortex / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009118:Muscimol; D000841:Anisomycin; D004640:Emetine