title: Tibial bone lead, but not serum polychlorinated biphenyl, concentrations are associated with neurocognitive deficits in former capacitor workers.
abstract: OBJECTIVE
  To determine the relationships between tibial bone lead and serum polychlorinated biphenyl (PCB) concentrations and neurocognitive function.
  
  
  METHODS
  The study population consisted of men and women former capacitor workers had been employed by the General Electric Corporation between 1946 and 1977. Regression analyses evaluated the association between neurocognitive function and lipid-adjusted serum PCB and tibia lead concentrations.
  
  
  RESULTS
  Tibia lead, but not serum PCBs, was significantly correlated with deficits in neurocognitive function. Women showed more associations between tibia lead and neurocognitive function than men, especially regarding executive function.
  
  
  CONCLUSIONS
  These results demonstrate that low levels of tibia lead, but not serum PCBs, are associated with neurocognitive deficits and that postmenopausal women show a greater number of deficits in executive function than men.
authors.affiliation: Wadsworth Center, New York State Department of Health, Albany 12201, USA. seegal@wadsworth.org
authors.forename: Richard F
authors.initials: RF
authors.lastname: Seegal
authors.forename: Edward F
authors.initials: EF
authors.lastname: Fitzgerald
authors.forename: Robert J
authors.initials: RJ
authors.lastname: McCaffrey
authors.forename: Srishti
authors.initials: S
authors.lastname: Shrestha
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Hills
authors.forename: Mary S
authors.initials: MS
authors.lastname: Wolff
authors.forename: Richard F
authors.initials: RF
authors.lastname: Haase
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Todd
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Parsons
authors.forename: Eric S
authors.initials: ES
authors.lastname: Molho
authors.forename: Donald S
authors.initials: DS
authors.lastname: Higgins
authors.forename: Stewart A
authors.initials: SA
authors.lastname: Factor
authors.forename: John P
authors.initials: JP
authors.lastname: Seibyl
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000097:blood / Q000139:chemically induced / Q000453:epidemiology*; D055615:Electrical Equipment and Supplies; D056344:Executive Function; D005260:Female; D006801:Humans; D007221:Industry; D007854:Lead / Q000032:analysis* / Q000633:toxicity; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009518:New York / Q000453:epidemiology; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D011078:Polychlorinated Biphenyls / Q000097:blood* / Q000633:toxicity; D017698:Postmenopause / Q000523:psychology; D011930:Reaction Time; D012737:Sex Factors; D013977:Tibia / Q000737:chemistry*
chemical_list: D007854:Lead; D011078:Polychlorinated Biphenyls