title: Classical conditioning of motor responses: what is the learning mechanism?
abstract: According to a widely held assumption, the main mechanism underlying motor learning in the cerebellum, such as eyeblink conditioning, is long-term depression (LTD) of parallel fibre to Purkinje cell synapses. Here we review some recent physiological evidence from Purkinje cell recordings during conditioning with implications for models of conditioning. We argue that these data pose four major challenges to the LTD hypothesis of conditioning. (i) LTD cannot account for the pause in Purkinje cell firing that is believed to drive the conditioned blink. (ii) The temporal conditions conducive to LTD do not match those for eyeblink conditioning. (iii) LTD cannot readily account for the adaptive timing of the conditioned response. (iv) The data suggest that parallel fibre to Purkinje cell synapses are not depressed after learning a Purkinje cell CR. Models based on metabotropic glutamate receptors are also discussed and found to be incompatible with the recording data.
authors.affiliation: Lund University, Department of Experimental Medicine, Lund, Sweden. Electronic address: Germund.Hesslow@med.lu.se.
authors.forename: Germund
authors.initials: G
authors.lastname: Hesslow
authors.forename: Dan-Anders
authors.initials: DA
authors.lastname: Jirenhed
authors.forename: Anders
authors.initials: A
authors.lastname: Rasmussen
authors.forename: Fredrik
authors.initials: F
authors.lastname: Johansson
mesh_terms: D000818:Animals; D003214:Conditioning, Classical / Q000502:physiology*; D006801:Humans; D036881:Long-Term Synaptic Depression; D008959:Models, Neurological; D009043:Motor Activity / Q000502:physiology*; D011689:Purkinje Cells / Q000502:physiology*; D013997:Time Factors
keywords: Cerebellum; Conditioning; Learning; Purkinje cells; Temporal; Timing