title: Influence of decreased intracellular glutathione level on the mutagenicity of patulin in cultured mouse lymphoma cells.
abstract: The mutagenicity of the mycotoxin patulin was assessed by the thymidine kinase mutation assay, which is based on point mutations and deletions. Patulin was mutagenic in cultured mouse lymphoma cells and the mutagenicity was significantly increased in cells pretreated with buthionine sulfoximine, which reduces intracellular glutathione levels.
authors.affiliation: Institute of Food Chemistry and Toxicology, University of Karlsruhe, Kaiserstrasse 12, D-76128, Karisruhe, Schumacher@lmcuni-karlsruhe.ce.
authors.forename: D M
authors.initials: DM
authors.lastname: Schumacher
authors.forename: J
authors.initials: J
authors.lastname: Wagner
authors.forename: M
authors.initials: M
authors.lastname: Metzler
authors.forename: L
authors.initials: L
authors.lastname: Lehmann