title: Scleroderma renal crisis and ovarian hyperstimulation syndrome related to the use of clomiphene in a patient with scleroderma.
abstract: This paper presented a 28-year-old female with systemic sclerosis who developed scleroderma renal crisis and ovarian hyperstimulation syndrome following clomiphene administration. Urgent therapy including angiotensin-converting enzyme (ACE) inhibitors and supportive care resulted in regression and eventually resolution of all the clinical and laboratory symptoms. Although scleroderma renal crisis is a fatal complication of high-dose corticosteroids, rarely is this seen with the use of ACE inhibitors. This case report aimed to investigate the potential capacity of the selective oestrogen receptor modulator clomiphene to induce scleroderma renal crisis as well as corticosteroids.
authors.affiliation: Şifa University, Faculty of Medicine, Department of Rheumatology, Turkey. Electronic address: senolkobak@yahoo.com.
authors.forename: Senol
authors.initials: S
authors.lastname: Kobak
authors.affiliation: Çanakkale Onsekiz Mart University, Faculty of Medicine, Department of Obstetrics and Gynecology, Turkey.
authors.forename: Servet
authors.initials: S
authors.lastname: Hacivelioglu
authors.affiliation: Çanakkale Onsekiz Mart University, Faculty of Medicine, Department of Internal Medicine, Turkey.
authors.forename: Selen
authors.initials: S
authors.lastname: Gungor
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000209:etiology; D000328:Adult; D002996:Clomiphene / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000209:etiology; D012595:Scleroderma, Systemic / Q000150:complications*; D020845:Selective Estrogen Receptor Modulators / Q000009:adverse effects*
chemical_list: D020845:Selective Estrogen Receptor Modulators; D002996:Clomiphene
keywords: Clomifeno; Clomiphene; Crisis renal por esclerodermia; Ovarian hyperstimulation syndrome; Scleroderma renal crisis; Síndrome de hiperestimulación ovárica