title: Beneficial regulation of type I collagen and matrixmetalloproteinase-1 expression by estrogen, progesterone, and its combination in skin fibroblasts.
abstract: There is impaired wound healing and loss of type I collagen in skin aging, which can be improved by topical estrogen in vivo. The goal of this study was to determine the effects of estrogen, and progesterone and a combination of estrogen and progesterone as well, on the proliferation and the expression of type I collagen and matrixmetalloprotienase-1 (MMP-1, degrades collagen) in dermal fibroblasts (cells that synthesize collagen and MMP-1) in-vitro. Estrogen, progesterone, and its combination similarly and significantly inhibited cell proliferation and MMP-1 protein levels, and simultaneously stimulated type I collagen expression in the fibroblasts, indicating beneficial modulation.
authors.affiliation: Biology and Chemistry/Biochemistry, Georgian Court College, 900 Lakewood Avenue, Lakewood, NJ 08701 USA.
authors.forename: Neena
authors.initials: N
authors.lastname: Philips
authors.forename: Jan
authors.initials: J
authors.lastname: Devaney