title: [Correlation of Eps8 with proliferation, metastasis and prognosis of malignant tumors].
abstract: Epidermal growth factor receptor pathway substrate 8 (Eps8) is one of crucial kinase substrates for the epidermal growth factor receptors. Eps8 is related to mitosis and differentiation of normal cells. In recent years, it has been demonstrated that Eps8 involves in proliferation, metastasis and prognosis of many malignant tumors. Experiments have shown that Eps8 involves in Ras-Rac pathway of EGFR signaling by forming Eps8-Abi1-Sos1 tri-complex or participates in endocytosis mediated by rab5. Furthermore, Eps8 has also been found to regulate cell cycle. In conclusion, it may become a monitor and a new target for the treatment of malignant tumors. This review briefly introduces molecular structure and physiological function of Eps8, focusing on its function and molecular mechanism in proliferation, metastasis and prognosis of malignant tumors.
authors.affiliation: Second Clinical Medical College of Southern Medical University, Guangdong Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Lu-Yang
authors.initials: LY
authors.lastname: Jin
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Wang
authors.forename: Jing-Qian
authors.initials: JQ
authors.lastname: Zhou
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Li
authors.forename: Ying-Zhi
authors.initials: YZ
authors.lastname: He
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Li
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C489989:EPS8 protein, human