title: Cotton wool-like poly(lactic acid)/vaterite composite scaffolds releasing soluble silica for bone tissue engineering.
abstract: Cotton wool-like poly(L-lactic acid) and siloxane-doped vaterite (SiV) composite scaffolds were prepared with a modified electrospinning system for bone tissue engineering applications. The effects of changing the SiV content in the materials from 10 to 30 wt% on elasticity and the ability to release calcium ions and soluble silica were evaluated. The elasticity of the cotton wool-like composites was almost the same as that of the PLLA from the results of compressibility and recovery tests. The materials released calcium ions for more than 56 days and soluble silica for 28-56 days in a tris buffer solution (pH 7.4). Mouse osteoblast-like cells (MC3T3-E1 cells) were cultured on/in the cotton wool-like materials or the fibremats out of the same composite materials as that used for the cotton wool-like materials. The cells penetrated into and proliferated inside the cotton wool-like materials, although they mainly adhered on the fibremat surface.
authors.affiliation: Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan. obata.akiko@nitech.ac.jp
authors.forename: Akiko
authors.initials: A
authors.lastname: Obata
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ozasa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kasuga
authors.forename: Julian R
authors.initials: JR
authors.lastname: Jones
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D002119:Calcium Carbonate / Q000737:chemistry* / Q000493:pharmacokinetics; D002478:Cells, Cultured; D032561:Cotton Fiber; D048091:Guided Tissue Regeneration / Q000295:instrumentation / Q000379:methods; D019344:Lactic Acid / Q000737:chemistry* / Q000493:pharmacokinetics; D008422:Materials Testing; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D011091:Polyesters; D011108:Polymers / Q000737:chemistry* / Q000493:pharmacokinetics; D012822:Silicon Dioxide / Q000737:chemistry / Q000493:pharmacokinetics*; D012995:Solubility; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry; D014935:Wool / Q000737:chemistry
chemical_list: D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D012822:Silicon Dioxide; D002119:Calcium Carbonate