title: The iron link between malaria and invasive non-typhoid Salmonella infections.
abstract: Epidemiological studies have demonstrated an association between malaria and invasive non-typhoid Salmonella (NTS) infections, especially in children. We explore the role of iron as a possible cofactor in this association. Malarial disease, among others, is associated with enhanced erythrophagocytosis and inflammation, which increases the iron content of macrophages and thereby also the survival of Salmonella spp. within macrophages. Whether iron supplementation programs augment the risk of invasive NTS infections in malaria-endemic regions is an important global health issue that still needs to be determined.
authors.affiliation: Department of General Internal Medicine, Nijmegen Institute for International Health (456), Radboud University Medical Center, Geert Grooteplein Zuid 8, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Susanne
authors.initials: S
authors.lastname: van Santen
authors.forename: Quirijn
authors.initials: Q
authors.lastname: de Mast
authors.forename: Dorine W
authors.initials: DW
authors.lastname: Swinkels
authors.forename: André J A M
authors.initials: AJ
authors.lastname: van der Ven
mesh_terms: D000818:Animals; D002648:Child; D060085:Coinfection; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology; D006706:Homeostasis; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007501:Iron / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D016778:Malaria, Falciparum / Q000150:complications* / Q000276:immunology; D010963:Plasmodium falciparum / Q000502:physiology*; D012475:Salmonella / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity; D012480:Salmonella Infections / Q000150:complications* / Q000276:immunology
chemical_list: D007501:Iron