title: Asymptomatic/pauci-symptomatic creatine kinase elevations (hyperckemia).
abstract: Neuromuscular clinicians are frequently asked to evaluate patients referred for asymptomatic elevations in creatine kinase (CK), a catalytic enzyme that combines creatine and ATP to form phosphocreatine and ADP. This reaction is crucial for cellular energy generation and metabolism. This laboratory finding, often referred to in simplified lexicon as asymptomatic hyperCKemia, continues to generate controversy at several levels, including definition, the extent of evaluation, and the yield of diagnostic testing. In this review, we summarize the literature based on series of patients with asymptomatic hyperCKemia and provide a rational clinical approach to reveal identifiable underlying causes.
authors.affiliation: Department of Neurology, University at Buffalo, Buffalo General Medical Center, 100 High Street, Buffalo, New York 14203-1126, USA. njs6@buffalo.edu
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Silvestri
authors.forename: Gil I
authors.initials: GI
authors.lastname: Wolfe
mesh_terms: D058070:Asymptomatic Diseases; D003402:Creatine Kinase / Q000097:blood*; D003937:Diagnosis, Differential; D006801:Humans; D008659:Metabolic Diseases / Q000097:blood / Q000175:diagnosis*; D009135:Muscular Diseases / Q000175:diagnosis*; D012016:Reference Values
chemical_list: D003402:Creatine Kinase