title: Re-irradiation of recurrent head and neck carcinomas: comparison of robust intensity modulated proton therapy treatment plans with helical tomotherapy.
abstract: BACKGROUND
  To test the hypothesis that the therapeutic ratio of intensity-modulated photon therapy using helical tomotherapy (HT) for retreatment of head and neck carcinomas can be improved by robust intensity-modulated proton therapy (IMPT).
  
  
  METHODS
  Comparative dose planning with robust IMPT was performed for 7 patients retreated with HT.
  
  
  RESULTS
  On average, HT yielded dose gradients steeper in a distance ≤ 7.5 mm outside the target (p<0.0001, F-test) and more conformal high dose regions down to the 50% isodose than IMPT. Both methods proved comparably robust against set-up errors of up to 2 mm, and normal tissue exposure was satisfactory. The mean body dose was smaller with IMPT.
  
  
  CONCLUSIONS
  IMPT was found not to be uniformly superior to HT and the steeper average dose fall-off around the target volume is an argument pro HT under the methodological implementations used. However, looking at single organs at risk, the normal tissue sparing of IMPT can surpass tomotherapy for an individual patient. Therefore, comparative dose planning is recommended, if both methods are available.
authors.affiliation: Department of Radiotherapy, University Duisburg-Essen, Essen, Germany. martin.stuschke@uk-essen.de
authors.forename: Martin
authors.initials: M
authors.lastname: Stuschke
authors.forename: Andreas
authors.initials: A
authors.lastname: Kaiser
authors.forename: Jehad
authors.initials: J
authors.lastname: Abu-Jawad
authors.forename: Christoph
authors.initials: C
authors.lastname: Pöttgen
authors.forename: Sabine
authors.initials: S
authors.lastname: Levegrün
authors.forename: Jonathan
authors.initials: J
authors.lastname: Farr
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D061766:Proton Therapy / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D000077195:Squamous Cell Carcinoma of Head and Neck