title: A case report of paraneoplastic pemphigus associated with esophageal squamous cell carcinoma.
abstract: Paraneoplastic pemphigus is an autoimmune blistering and erosive mucocutaneous syndrome associated with underlying neoplasm. It is primarily associated with lymphoproliferative disorders, and uncommonly with malignancies of epithelial origin. We report on a case of a 68-year-old male who presented with whole body bullous and erosive skin lesions. Findings on upper gastrointestinal endoscopy and skin biopsy revealed esophageal squamous cell carcinoma and paraneoplastic pemphigus. Palliative chemotherapy and systemic glucocorticoid were started, however, the patient died of overwhelming sepsis on the ninth day of chemotherapy. This case demonstrates that paraneoplastic pemphigus can occur in esophageal squamous cell carcinoma and could be a cause of morbidity.
authors.affiliation: Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Jin Hyun
authors.initials: JH
authors.lastname: Cho
authors.forename: Nam Jun
authors.initials: NJ
authors.lastname: Kim
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Ko
authors.forename: Chunghun
authors.initials: C
authors.lastname: Kim
authors.forename: Hee Kyung
authors.initials: HK
authors.lastname: Ahn
authors.forename: Jina
authors.initials: J
authors.lastname: Yun
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Park
keywords: Esophageal neoplasms; Paraneoplastic syndromes; Pemphigus; Squamous cell carcinoma