title: [P73 gene expression in gliomas].
abstract: We propose an RT-PCR primer system allowing a definite mRNA identification for different p73 (p53 homologue) isoforms identification. Using the system proposed the p73 expression was studied in 18 glioma samples (cell lines, biopsy samples, primary cultures). Most of the samples reveal no p73 expression or it is expressed simultaneously with its isoforms shown to suppress its activity. This expression pattern predisposes to cancerogenesis.
authors.forename: A V
authors.initials: AV
authors.lastname: Volnitskiĭ
authors.forename: G R
authors.initials: GR
authors.lastname: Vinogradskaia
authors.forename: M V
authors.initials: MV
authors.lastname: Filatov
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001706:Biopsy; D001932:Brain Neoplasms / Q000737:chemistry*; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000032:analysis* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000737:chemistry*; D006801:Humans; D009687:Nuclear Proteins / Q000032:analysis* / Q000235:genetics; D012313:RNA; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D014407:Tumor Cells, Cultured; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins / Q000032:analysis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C034477:RNA primers; D012333:RNA, Messenger; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins; D012313:RNA