title: Management of drug induced sexual dysfunction in male rats by ethyl acetate fraction of onion.
abstract: The present study aimed to investigate the effect of ethyl acetate fraction of A. cepa bulb on mating behavior in paroxetine-induced sexually dysfunction male rats. Sexual dysfunctions such as decreased libido, delayed orgasm, difficulties in maintaining an erection, and inhibition of ejaculation are common side effects of paroxetine. A. cepa bulb ethyl acetate fraction (200 mg/kg) was administered orally in paroxetine-induced sexually impaired male rats for 7 days. At the end of 7th day, mount frequency (MF), intromission frequency (IF), ejaculatory frequency (EF), mount latency (ML), intromission latency (IL), ejaculatory latency (EL) and post-ejaculatory interval (PEI) were the parameters observed. Results showed that in relation to the paroxetine treated group, ethyl acetate fraction, significantly restored the normal sexual behavior as evident from increased MF, IF, EF and reduced ML, IL, EL and PEI.
authors.affiliation: Smriti College of Pharmaceutical Education, Indore, India. nil30oct@gmail.com
authors.forename: Neelesh
authors.initials: N
authors.lastname: Malviya
authors.forename: Sanjay
authors.initials: S
authors.lastname: Jain
authors.forename: Vipin Bihari
authors.initials: VB
authors.lastname: Gupta
authors.forename: Savita
authors.initials: S
authors.lastname: Vyas
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000818:Animals; D004195:Disease Models, Animal; D004542:Ejaculation / Q000187:drug effects; D005260:Female; D007989:Libido / Q000187:drug effects; D008297:Male; D019697:Onions / Q000737:chemistry; D017374:Paroxetine; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time; D012726:Sexual Behavior, Animal / Q000187:drug effects; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D012997:Solvents / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000085:Acetates; D010936:Plant Extracts; D012997:Solvents; D017374:Paroxetine; C007650:ethyl acetate