title: [Correlation between in vitro release and in vivo absorption of sustained-releasing tablets of neostigmine bromide].
abstract: OBJECTIVE
  To determine the correlation between in vitro release and in vivo absorption of sustained-releasing tablets of neostigmine bromide.
  
  
  METHODS
  Water was used as dissolution medium to measured in vitro release of neostigmine bromide. After a single oral administration of 100 mg neostigmine bromide to rabbits, the plasma concentrations of neostigmine bromide in the rabbits were determined by HPLC. The compartment model and deconvolution method were employed to explain the in vitro-in vivo correlation.
  
  
  RESULTS
  Using Y as cumulative in vitro release and Fa as percentage of absorption, the regression equation was established: Fa = 0.9298Y + 4.6074, r = 0.9961. The input function of R = 2.0163Y-11.242,r = 0.9270.
  
  
  CONCLUSIONS
  The correlation between in vitro release and in vivo absorption of neostigmine bromide is good.
authors.affiliation: Medicine Engineering Research Center, Chongqing Key Laboratory of Biochemical&Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Luo
authors.forename: Qun-You
authors.initials: QY
authors.lastname: Tan
authors.forename: Hua-Rong
authors.initials: HR
authors.lastname: Xiong
authors.forename: Chun-Jing
authors.initials: CJ
authors.lastname: Zhao
authors.forename: Jing-Qing
authors.initials: JQ
authors.lastname: Zhang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics; D009388:Neostigmine / Q000493:pharmacokinetics*; D011817:Rabbits; D012995:Solubility; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D013607:Tablets; D009388:Neostigmine