title: [Molecular basis of oncogenesis induced by human papilloma viruses].
abstract: Human papilloma viruses (HPV) of high carcinogenesis risk play important role in development of cancer of oropharyngeal and anogenital areas. Possible malignant transformation of cells, infected by HPV, is due to the expression of three proteins, E6, E7 and E5. These proteins mostly influence on mechanisms that regulate cellular cycle, proliferation and apoptosis inducing and maintaining oncogenesis. This review briefly presents data on malignant tumors induced by HPV as well as biology of these viruses and their vital cycle. Special accent is made on description of current trends in molecular basis of oncogenesis, induced by HPV, which understanding is necessary for elaboration of new methods of treatment for HPV-infection such as therapeutic vaccines.
authors.forename: P V
authors.initials: PV
authors.lastname: Korita
authors.forename: O E
authors.initials: OE
authors.lastname: Trotsenko
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Annenkov
authors.forename: V V
authors.initials: VV
authors.lastname: Filimonov
mesh_terms: D052685:Alphapapillomavirus / Q000472:pathogenicity*; D001005:Anus Neoplasms / Q000378:metabolism / Q000821:virology; D017209:Apoptosis / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D015967:Gene Expression Regulation, Viral; D005833:Genital Neoplasms, Female / Q000378:metabolism / Q000821:virology; D005834:Genital Neoplasms, Male / Q000378:metabolism / Q000821:virology; D016679:Genome, Viral; D042822:Genomic Instability; D006801:Humans; D008297:Male; D008597:Menstrual Cycle; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000821:virology*; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism*; D009959:Oropharyngeal Neoplasms / Q000378:metabolism / Q000821:virology; D050725:Papillomavirus E7 Proteins / Q000378:metabolism; D030361:Papillomavirus Infections / Q000150:complications* / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D000086082:Viroporin Proteins
chemical_list: D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D012097:Repressor Proteins; C068651:E6 protein, Human papillomavirus type 16; C054859:oncogene protein E5, Human papillomavirus type 16; D000086082:Viroporin Proteins