title: A study of glycogen storage disease with 99Tcm-MIBI gated myocardial perfusion imaging.
abstract: OBJECTIVE
  Gated myocardial perfusion imaging (G-MPI) is regularly performed using single-photon emission computed tomography. The objective of this study was to evaluate the clinical value of 99Tcm-methoxyisobutylisonitrile (MIBI) myocardial imaging in glycogen storage disease (GSD).
  
  
  METHODS
  99Tcm-MIBI G-MPI was performed in nine patients with clinically proven GSD. QGS quantitative software was used for processing and interpretation. Left ventricular ejection fraction (LVEF), end-diastolic volume (EDV) and end-systolic volume (ESV) were automatically generated. The myocardium was divided into seven segments, 20 sub-segments and a five-point scoring system was used.
  
  
  RESULTS
  Seven out of nine cases were abnormal and the positive rate of G-MPI was 77.8 %. Sixty-two sub-segments of injured myocardium were detected in 140 sub-segments of seven abnormal patients. One injured segment was observed in one patient (14.3 %), two segments were detected in two patients (28.6 %) and three or more abnormal segments were observed in four patients (57.1 %).
  
  
  CONCLUSIONS
  99Tcm-MIBI G-MPI can detect myocardial damage in GSD as a non-invasive method. It plays an important role in the clinic.
authors.affiliation: Department of Nuclear Medicine, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050051, China, weilingge@126.com.
authors.forename: L G
authors.initials: LG
authors.lastname: Wei
authors.forename: J Q
authors.initials: JQ
authors.lastname: Gao
authors.forename: X M
authors.initials: XM
authors.lastname: Liu
authors.forename: J M
authors.initials: JM
authors.lastname: Huang
authors.forename: X Z
authors.initials: XZ
authors.lastname: Li
mesh_terms: D000293:Adolescent; D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006008:Glycogen Storage Disease / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D019275:Radiopharmaceuticals; D013318:Stroke Volume; D017256:Technetium Tc 99m Sestamibi; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology; D016277:Ventricular Function, Left; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi