title: Fatigue design of a mechanically biocompatible lattice for a proof-of-concept femoral stem.
abstract: A methodology is proposed to design a spatially periodic microarchitectured material for a two-dimensional femoral implant under walking gait conditions. The material is composed of a graded lattice with controlled property distribution that minimizes concurrently bone resorption and interface failure. The periodic microstructure of the material is designed for fatigue fracture caused by cyclic loadings on the hip joint as a result of walking. The bulk material of the lattice is Ti6AL4V and its microstructure is assumed free of defects. The Soderberg diagram is used for the fatigue design under multiaxial loadings. Two cell topologies, square and Kagome, are chosen to obtain optimized property gradients for a two-dimensional implant. Asymptotic homogenization (AH) theory is used to address the multiscale mechanics of the implant as well as to capture the stress and strain distribution at both the macro and the microscale. The microstress distribution found with AH is also compared with that obtained from a detailed finite element analysis. For the maximum value of the von Mises stress, we observe a deviation of 18.6% in unit cells close to the implant boundary, where the AH assumption of spatial periodicity of the fluctuating fields ceases to hold. In the second part of the paper, the metrics of bone resorption and interface shear stress are used to benchmark the graded cellular implant with existing prostheses made of fully dense titanium implant. The results show that the amount of initial postoperative bone loss for square and Kagome lattice implants decreases, respectively, by 53.8% and 58%. In addition, the maximum shear interface failure at the distal end is significantly reduced by about 79%. A set of proof-of-concepts of planar implants have been fabricated via Electron Beam Melting (EBM) to demonstrate the manufacturability of Ti6AL4V into graded lattices with alternative cell size. Optical microscopy has been used to measure the morphological parameters of the cellular microstructure, including cell wall thickness and pore size, and compared them with the nominal values. No sign of fracture or incomplete cell walls was observed, an assessment that shows the satisfactory metallurgical bond of cell walls and the structural integrity of the implants.
authors.affiliation: Mechanical Engineering Department, McGill University Montreal, QC, Canada H3A 2K6. sajad.arabnejadkhanoki@mail.mcgill.ca
authors.forename: Sajad
authors.initials: S
authors.lastname: Arabnejad Khanoki
authors.forename: Damiano
authors.initials: D
authors.lastname: Pasini
mesh_terms: D000328:Adult; D001672:Biocompatible Materials; D001862:Bone Resorption; D005269:Femur / Q000502:physiology; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D008422:Materials Testing; D055595:Mechanical Phenomena; D019736:Prostheses and Implants; D011474:Prosthesis Design / Q000379:methods*; D016138:Walking
chemical_list: D001672:Biocompatible Materials