title: Automated midline shift and intracranial pressure estimation based on brain CT images.
abstract: In this paper we present an automated system based mainly on the computed tomography (CT) images consisting of two main components: the midline shift estimation and intracranial pressure (ICP) pre-screening system. To estimate the midline shift, first an estimation of the ideal midline is performed based on the symmetry of the skull and anatomical features in the brain CT scan. Then, segmentation of the ventricles from the CT scan is performed and used as a guide for the identification of the actual midline through shape matching. These processes mimic the measuring process by physicians and have shown promising results in the evaluation. In the second component, more features are extracted related to ICP, such as the texture information, blood amount from CT scans and other recorded features, such as age, injury severity score to estimate the ICP are also incorporated. Machine learning techniques including feature selection and classification, such as Support Vector Machines (SVMs), are employed to build the prediction model using RapidMiner. The evaluation of the prediction shows potential usefulness of the model. The estimated ideal midline shift and predicted ICP levels may be used as a fast pre-screening step for physicians to make decisions, so as to recommend for or against invasive ICP monitoring.
authors.affiliation: Department of Biostatistics, Virginia Commonwealth University.
authors.forename: Wenan
authors.initials: W
authors.lastname: Chen
authors.forename: Ashwin
authors.initials: A
authors.lastname: Belle
authors.forename: Charles
authors.initials: C
authors.lastname: Cockrell
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Ward
authors.forename: Kayvan
authors.initials: K
authors.lastname: Najarian
mesh_terms: D001921:Brain / Q000033:anatomy & histology* / Q000473:pathology; D001930:Brain Injuries / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D019586:Intracranial Hypertension / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D007427:Intracranial Pressure / Q000502:physiology*; D060388:Support Vector Machine; D014057:Tomography, X-Ray Computed / Q000379:methods*