title: Organocatalyzed asymmetric synthesis of morphans.
abstract: A general effective organocatalyzed synthesis of enantioenriched morphans with up to 92% ee was developed. The morphan scaffold was constructed in a one-pot tandem asymmetric organocatalyzed Michael addition followed by a domino Robinson annulation/aza-Michael intramolecular reaction sequence from easily available starting materials.
authors.affiliation: Laboratori de Química Orgánica, Facultat de Farmàcia, IBUB, Universitat de Barcelona , Av. Joan XXIII, s/n, 08028, Barcelona, Spain.
authors.forename: Ben
authors.initials: B
authors.lastname: Bradshaw
authors.forename: Claudio
authors.initials: C
authors.lastname: Parra
authors.forename: Josep
authors.initials: J
authors.lastname: Bonjoch
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001372:Aza Compounds