title: The effect of dietary intake of the acidic protein fraction of bovine colostrum on influenza A (H1N1) virus infection.
abstract: Acidic protein levels in the milk decrease markedly as lactation progresses, suggesting that it is an important part of the colostrum. However, little attention has been paid to their biological function. In this study, we isolated the acidic protein fraction of bovine colostrum (AFC, isoelectric point <5) by anion-exchange chromatography, and investigated the effect of its dietary intake on influenza A (H1N1) virus infection. 100% of mice infected with 1 LD50 of the virus survived when administered AFC for 14 days prior to infection, compared with 33% survival when administered phosphate buffered saline (PBS). Moreover, consumption of AFC reduced the weight loss associated with infection. We propose that dietary intake of AFC has a prophylactic effect on influenza A virus infection.
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Mei Ling
authors.initials: ML
authors.lastname: Xu
authors.forename: Hyoung Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Don Yong
authors.initials: DY
authors.lastname: Chang
authors.forename: Hong-Jin
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D002417:Cattle; D003126:Colostrum / Q000737:chemistry*; D005260:Female; D053118:Influenza A Virus, H1N1 Subtype / Q000472:pathogenicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D011506:Proteins / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D011506:Proteins