title: Hybrid micro/nano-topography of a TiO2 nanotube-coated commercial zirconia femoral knee implant promotes bone cell adhesion in vitro.
abstract: Various approaches have been studied to engineer the implant surface to enhance bone in-growth properties, particularly using micro- and nano-topography. In this study, the behavior of osteoblast (bone) cells was analyzed in response to a titanium oxide (TiO2) nanotube-coated commercial zirconia femoral knee implant consisting of a combined surface structure of a micro-roughened surface with the nanotube coating. The osteoblast cells demonstrated high degrees of adhesion and integration into the surface of the nanotube-coated implant material, indicating preferential cell behavior on this surface when compared to the bare implant. The results of this brief study provide sufficient evidence to encourage future studies. The development of such hierarchical micro- and nano-topographical features, as demonstrated in this work, can provide insightful designs for advanced bone-inducing material coatings on ceramic orthopedic implant surfaces.
authors.affiliation: Materials Science & Engineering, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Christine J
authors.initials: CJ
authors.lastname: Frandsen
authors.forename: Kunbae
authors.initials: K
authors.lastname: Noh
authors.forename: Karla S
authors.initials: KS
authors.lastname: Brammer
authors.forename: Gary
authors.initials: G
authors.lastname: Johnston
authors.forename: Sungho
authors.initials: S
authors.lastname: Jin
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001842:Bone and Bones / Q000166:cytology*; D002448:Cell Adhesion; D005269:Femur; D006622:Hip Prosthesis; D007720:Knee Prosthesis; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D043942:Nanotubes; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D015040:Zirconium
chemical_list: C009495:titanium dioxide; D015040:Zirconium; D014025:Titanium