title: [Effects of anti-edema drugs on diffuse cerebral edema in rats: experimental study].
abstract: BACKGROUND
  Traumatic brain edema is one of the most common problems encountered in neurosurgical practice and it leads to morbidity and mortality via increased intracranial pressure. The aim of this study was to examine the effect of hypertonic saline on traumatic brain edema in comparison to mannitol.
  
  
  METHODS
  Eighty adult male Sprauge-Dawley rats weighting 300-350 g were used in this experimental study. Rats were randomly divided into control (C); trauma (T); mannitol only trauma+mannitol; NaCl 3% only; Trauma+NaCl 3%; NaCl 7.5% only; trauma+NaCl 7.5%; NaCl 23.4% only and trauma+NaCl 23.4% groups. All medications were given intraperitoneally. Rats were sacrificed and decapitated 24 hours after trauma with or without medications and the brains were examined histopatologically.
  
  
  RESULTS
  Although no difference was observed with regard to hemorrhage between trauma only and trauma+NaCl 23.4% groups, there was a statistically significant difference in brain edema within these two groups (p=0.003). There were no statistically significant differences within groups with respect to plasma osmolarity and serum sodium levels.
  
  
  CONCLUSIONS
  This study demonstrates that 23.4% NaCl is more effective than other concentrations of hypertonic saline or mannitol in the prevention of posttraumatic brain edema. Further clinical studies with different dosages and concentrations of hypertonic saline are required.
authors.affiliation: Department of Neurosurgery, Düzce Atatürk State Hospital, Düzce, Turkey.
authors.forename: Fevzullah
authors.initials: F
authors.lastname: Akyüz
authors.forename: Merih
authors.initials: M
authors.lastname: Iş
authors.forename: Hikmet
authors.initials: H
authors.lastname: Aytekin
authors.forename: Murat
authors.initials: M
authors.lastname: Anlar
authors.forename: Osman
authors.initials: O
authors.lastname: Akgül
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D001929:Brain Edema / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D001930:Brain Injuries / Q000097:blood / Q000503:physiopathology*; D004573:Electrolytes / Q000097:blood; D008297:Male; D008353:Mannitol / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D004573:Electrolytes; D008353:Mannitol; D012965:Sodium Chloride