title: Synthesis of 2-methoxybenzoylhydrazone and evaluation of their antileishmanial activity.
abstract: Compounds 1-25 showed varying degree of antileishmanial activities with IC50 values ranging between 1.95 and 88.56 μM. Compounds 2, 10, and 11 (IC50=3.29±0.07 μM, 1.95±0.04 μM, and 2.49±0.03 μM, respectively) were found to be more active than standard pentamidine (IC50=5.09±0.04 μM). Compounds 7 (IC50=7.64±0.1 μM), 8 (IC50=13.17±0.46 μM), 18 (IC50=13.15±0.02 μM), and 24 (IC50=15.65±0.41 μM) exhibited good activities. Compounds 1, 3, 4, 5, 9, 12, 15, 18, and 19 were found to be moderately active. Compounds 13, 14, 16, 17, 20-25 showed weak activities with IC50 values ranging between 57 and 88 μM.
authors.affiliation: Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia. muhamm9000@puncakalam.uitm.edu.my
authors.forename: Muhammad
authors.initials: M
authors.lastname: Taha
authors.forename: Mohd Syukri
authors.initials: MS
authors.lastname: Baharudin
authors.forename: Nor Hadiani
authors.initials: NH
authors.lastname: Ismail
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Faridahanim Mohd
authors.initials: FM
authors.lastname: Jaafar
authors.lastname: Samreen
authors.forename: Salman
authors.initials: S
authors.lastname: Siddiqui
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007891:Leishmania / Q000187:drug effects; D010419:Pentamidine / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D006835:Hydrazones; D010419:Pentamidine