title: Congenital dyserythropoietic anemia type 1 with a novel mutation in the CDAN1 gene previously diagnosed as congenital hemolytic anemia.
abstract: The congenital dyserythropoietic anemias (CDAs) are a heterogeneous group of genetic disorders of red cell production. They are characterized by ineffective erythropoiesis and dyserythropoiesis. Here, we present the clinical description and mutation analysis of a Japanese female with CDA type 1. She has long been diagnosed with unclassified congenital hemolytic anemia from the neonatal period. However, bone marrow morphology and genetic testing of the CDAN1 gene at the age of 12 years confirmed the afore-mentioned diagnosis. Thus, we should be aware of the possibility of CDA if the etiology of congenital anemia or jaundice cannot be clearly elucidated.
authors.affiliation: Department of Pediatrics, Osaka Red Cross Hospital, Osaka, Osaka, Japan. hfujino11@gmail.com
authors.forename: Hisanori
authors.initials: H
authors.lastname: Fujino
authors.forename: Sayoko
authors.initials: S
authors.lastname: Doisaki
authors.forename: Young-Dong
authors.initials: YD
authors.lastname: Park
authors.forename: Asahito
authors.initials: A
authors.lastname: Hama
authors.forename: Hideki
authors.initials: H
authors.lastname: Muramatsu
authors.forename: Seiji
authors.initials: S
authors.lastname: Kojima
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sumimoto
mesh_terms: D000742:Anemia, Dyserythropoietic, Congenital / Q000175:diagnosis* / Q000235:genetics*; D000745:Anemia, Hemolytic, Congenital / Q000175:diagnosis*; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D005260:Female; D006023:Glycoproteins / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D009154:Mutation; D009687:Nuclear Proteins
chemical_list: C470477:CDAN1 protein, human; D006023:Glycoproteins; D009687:Nuclear Proteins