title: Molecular signaling toward mitophagy and its physiological significance.
abstract: Mitochondrial autophagy or mitophagy is a cellular metabolic pathway that mediates the selective elimination of dysfunctional or unwanted mitochondria. Considerable advancements have been made to elucidate the molecular mechanism behind mitophagy, particularly Parkin-mediated mitophagy. Several mitophagy receptors have been discovered in different physiological settings, including ATG32 in yeast as well as NIX, BNIP3, and FUNDC1 in mammalian cells. However, the signaling events that regulate these mitophagy receptors and their physiological significance in human diseases are poorly understood. In this paper, we review recent advancements in mitophagy at the cellular and molecular levels.
authors.affiliation: Key Laboratory of Age-associated Cardiac-cerebral Vascular Disease of Guangdong Province, Institute of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, China.
authors.forename: Du
authors.initials: D
authors.lastname: Feng
authors.affiliation: The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: College of Life Sciences, Nankai University, Tianjin 300071, China.
authors.forename: Yushan
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, Nankai University, Tianjin 300071, China. Electronic address: chenq@ioz.ac.cn.
authors.forename: Quan
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000235:genetics / Q000378:metabolism; D063154:Mitochondrial Dynamics / Q000235:genetics; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism; D063306:Mitophagy / Q000235:genetics*; D015398:Signal Transduction; D015003:Yeasts
chemical_list: D024101:Mitochondrial Proteins