title: β-Amyloid peptide (1-40) in the brain reaches the nasal cavity via a non-blood pathway.
abstract: We examined the distribution patterns of human β-amyloid (1-40) peptide labeled with iodine 125 ((125)I-Aβ40) after injections into the cerebral ventricle or tail vein of rats. In rats receiving an intravenous injection, the radioactive concentration of (125)I-Aβ40 in the nasal area was similar to other extracranial organs. In contrast, the caudal part of the nasal area in rats receiving an intracerebroventricular injection displayed a high level of (125)I-Aβ40 radioactivity. These results suggest that Aβ reaches the nasal cavity from the brain via a non-blood pathway.
authors.affiliation: Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu 520-2192, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Kameshima
authors.forename: Daijiro
authors.initials: D
authors.lastname: Yanagisawa
authors.forename: Ikuo
authors.initials: I
authors.lastname: Tooyama
mesh_terms: D016229:Amyloid beta-Peptides / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007150:Immunohistochemistry; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008822:Mice, Transgenic; D009296:Nasal Cavity / Q000378:metabolism*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D014018:Tissue Distribution
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40)