title: Trefoil factor 1 as a marker of mucosal damage of the gastrointestinal tract in children with sepsis.
abstract: Intestinal ischemia and reperfusion is a common pathway for many diseases in children. The objective of our study was an analysis of Trefoil factor 1 levels dynamics in patients with SIRS or septic condition during a 5-day period. Analysis of TFF1 levels dynamics revealed that TFF1 levels kept steady state during the 5-day period. TFF1 levels were similar in patients with SIRS, sepsis and severe sepsis. Significantly higher levels of TFF1 were in patients with septic shock and MODS.
authors.affiliation: Department of Anesthesia and Intensive Care, University Children's Hospital, Brno, 62500, Czech Republic. jzurek@fnbrno.cz
authors.forename: Jiří
authors.initials: J
authors.lastname: Žurek
authors.forename: Michal
authors.initials: M
authors.lastname: Fedora
mesh_terms: D000293:Adolescent; D019540:Area Under Curve; D015415:Biomarkers / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D012372:ROC Curve; D018805:Sepsis / Q000473:pathology*; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins