title: Cancer chromosomes going to POT1.
abstract: Alterations in the single-stranded telomere-binding protein POT1 have recently been identified in chronic lymphocytic leukemia. This discovery provides novel insights into how genomic instability induced by dysfunctional telomeres contributes to tumorigenesis.
authors.affiliation: Department of Laboratory Medicine and Pathology at Yale University School of Medicine, New Haven, Connecticut, USA. s.chang@yale.edu
authors.forename: Sandy
authors.initials: S
authors.lastname: Chang
mesh_terms: D059472:Exome / Q000235:genetics*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D000089804:Shelterin Complex; D016615:Telomere / Q000235:genetics*; D034501:Telomere-Binding Proteins / Q000235:genetics*
chemical_list: C440849:POT1 protein, human; D000089804:Shelterin Complex; D034501:Telomere-Binding Proteins