title: The role of C-type lectin receptors in immune homeostasis.
abstract: C-type lectin receptors (CLRs) are important pathogen pattern recognition molecules that recognize carbohydrate structures. Upon ligand binding, CLRs induce a variety of cellular responses, such as respiratory burst, production of cytokines and chemokines, and consequently shaping the adaptive immune responses. Recent frontier studies have demonstrated that CLRs play a significant role in development of anti-inflammatory immune responses and maintenance of host immune-homeostasis. In this review we describe the major CLRs involved in production of IL-10 by immune-related cells and functional maturation of regulatory T cells. In addition, we discuss the potential role of CLRs signaling in regulating intestinal immune-homeostasis and inflammation. Further understanding of the precise role for these receptors on immunoregulatory cells will provide unexpected opportunities for developing new therapies for inflammatory diseases.
authors.affiliation: Biomedial Research Institute, National Institute for Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan.
authors.forename: Huimin
authors.initials: H
authors.lastname: Yan
authors.forename: Naohito
authors.initials: N
authors.lastname: Ohno
authors.forename: Noriko M
authors.initials: NM
authors.lastname: Tsuji
mesh_terms: D000818:Animals; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology; D007422:Intestines / Q000276:immunology; D043183:Irritable Bowel Syndrome / Q000188:drug therapy / Q000276:immunology; D037181:Lectins, C-Type / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D037181:Lectins, C-Type; D016753:Interleukin-10