title: Selenylation modification can enhance immune-enhancing activity of Chinese angelica polysaccharide.
abstract: On the basis of previous test that selenizing Chinese angelica polysaccharides (sCAPs) with stronger immune-enhancing activity in vitro were picked out, the immune-enhancing activity in vivo of three sCAPs, sCAP2, sCAP6 and sCAP8, at high and low dosage were compared taking the unmodified Chinese angelica polysaccharide (CAP) as control by determination of peripheral lymphocyte proliferation, serum antibody titer, IFN-γ and IL-6 contents in chicken vaccinated with Newcastle Disease vaccine. The results showed that three sCAPs at suitable dosage could significantly promote lymphocyte proliferation, enhance serum antibody titer, IFN-γ and IL-6 contents as compared with unmodified CAP, sCAP2 at low dosage possessed the strongest action. These results indicated that selenylation modification could significantly enhance the immune-enhancing activity of CAP, sCAP2 possessed the best efficacy and would be as a component drug of new-type immunoenhancer.
authors.affiliation: Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Qin
authors.forename: Jin
authors.initials: J
authors.lastname: Chen
authors.forename: Deyun
authors.initials: D
authors.lastname: Wang
authors.forename: Yuanliang
authors.initials: Y
authors.lastname: Hu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Mi
authors.initials: M
authors.lastname: Wang
authors.forename: Shulei
authors.initials: S
authors.lastname: Qiu
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Gao
authors.forename: Rongrong
authors.initials: R
authors.lastname: liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Yu
authors.forename: Yee
authors.initials: Y
authors.lastname: Huang
authors.forename: Qiaochu
authors.initials: Q
authors.lastname: Wang
authors.forename: Qiaoxiu
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology*; D029971:Angelica sinensis; D000818:Animals; D002645:Chickens; D006385:Hemagglutination Inhibition Tests; D007371:Interferon-gamma / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D009522:Newcastle disease virus / Q000276:immunology; D017942:Nitric Acid / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D018038:Sodium Selenite / Q000737:chemistry*; D014765:Viral Vaccines / Q000008:administration & dosage
chemical_list: D000276:Adjuvants, Immunologic; D015850:Interleukin-6; D011134:Polysaccharides; D014765:Viral Vaccines; D017942:Nitric Acid; D007371:Interferon-gamma; D018038:Sodium Selenite