title: miR-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting EZH2.
abstract: Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic type of cancer that is widely prevalent in Southern China. Studies have shown that several microRNAs (miRNAs) are implicated in NPC metastasis. Our previous studies have demonstrated that miRNA miR-26a inhibits cell growth and tumorigenesis of NPC through the repression of enhancer of zeste homolog 2 (EZH2). However, the role of miR-26a in NPC metastasis remains unknown. In this study, we showed that ectopic expression of miR-26a inhibited the migratory and invasive capacities of NPC cellsin vitro. Additionally, we used a murine model to investigate the role of miR-26a in NPC metastasis and results showed that miR-26a overexpression suppresses the metastatic behavior of NPC cellsin vivo. Furthermore, the data demonstrated that miR-26a decreased the expression levels of EZH2in vitroandin vivo, suggesting that the antimetastatic effect of miR-26a in NPC was mediated by regulating EZH2. Therefore, these findings indicate that miR-26a functions as an antimetastatic miRNA in NPC and that its antimetastatic effects are mediated mainly by repressing EZH2 expression.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China ;
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.forename: Juan
authors.initials: J
authors.lastname: Lu
authors.forename: Bao
authors.initials: B
authors.lastname: Zhang
authors.forename: Xiong
authors.initials: X
authors.lastname: Liu
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Si-Yang
authors.initials: SY
authors.lastname: Li
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Peng
authors.forename: Xia
authors.initials: X
authors.lastname: Xu
authors.forename: Wen-Dong
authors.initials: WD
authors.lastname: Tian
authors.forename: Xiang-Ping
authors.initials: XP
authors.lastname: Li
keywords: enhancer of zeste homolog 2; metastasis; miR-26a; nasopharyngeal carcinoma