title: A biodegradable polymersome containing Bcl-xL siRNA and doxorubicin as a dual delivery vehicle for a synergistic anticancer effect.
abstract: Combined cancer treatment via co-delivery of siRNAs and an anticancer drug can be a promising strategy due to the synergistic effect of simultaneously minimizing gene/drug administration. In this study, Bcl-xL siRNA and doxorubicin (DOX) are encapsulated into designed methoxy-poly(ethylene glycol)-block-poly(D,L-lactic acid) (mPEG-b-PLA) block copolymer polymersomes (PSomes). A study of the cytotoxicity of Bcl-xL siRNA and DOX co-encapsulated PSomes (CPSomes) shows more inhibited proliferation of MKN-45 and MKN-28 human gastric cancer cell lines than only gene- and drug-loaded ones. Consequently, these results demonstrate that co-delivery of genes and drugs using PSomes results in a synergistic efficacy and indicates the potential of PSomes as efficient nanocarriers for combined cancer therapy.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Republic of Korea.
authors.forename: Hyun-Ouk
authors.initials: HO
authors.lastname: Kim
authors.forename: Eunjung
authors.initials: E
authors.lastname: Kim
authors.forename: Yonghee
authors.initials: Y
authors.lastname: An
authors.forename: Jihye
authors.initials: J
authors.lastname: Choi
authors.forename: Eunji
authors.initials: E
authors.lastname: Jang
authors.forename: Eun Bi
authors.initials: EB
authors.lastname: Choi
authors.forename: Aastha
authors.initials: A
authors.lastname: Kukreja
authors.forename: Myeong-Hoon
authors.initials: MH
authors.lastname: Kim
authors.forename: Byunghoon
authors.initials: B
authors.lastname: Kang
authors.forename: Dong-Joo
authors.initials: DJ
authors.lastname: Kim
authors.forename: Jin-Suck
authors.initials: JS
authors.lastname: Suh
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Huh
authors.forename: Seungjoo
authors.initials: S
authors.lastname: Haam
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001672:Biocompatible Materials / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D020285:Cryoelectron Microscopy; D004317:Doxorubicin / Q000494:pharmacology*; D016503:Drug Delivery Systems; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D020868:Gene Silencing / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D006868:Hydrolysis / Q000187:drug effects; D020128:Inhibitory Concentration 50; D007700:Kinetics; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism*; D013997:Time Factors; D051028:bcl-2-Associated X Protein / Q000235:genetics / Q000378:metabolism; D051020:bcl-X Protein / Q000235:genetics / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D011091:Polyesters; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D051028:bcl-2-Associated X Protein; D051020:bcl-X Protein; C492425:methoxy poly(ethylene glycol)-poly(lactide); D011092:Polyethylene Glycols; D004317:Doxorubicin