title: Targeting VEGF-VEGFR Pathway by Sunitinib in Peripheral Primitive Neuroectodermal Tumor, Paraganglioma and Epithelioid Hemangioendothelioma: Three Case Reports.
abstract: Sunitinib malate (Sutent(TM); Pfizer Inc., New York, N.Y., USA) is a small molecule kinase inhibitor with activity against a number of tyrosine kinase receptors, including vascular endothelial growth factor receptors, stem-cell factor receptor, and platelet-derived growth factor receptors alpha and beta. Sunitinib, registered for the treatment of renal cell carcinoma and gastrointestinal stromal tumors, has recently been approved for the treatment of patients with advanced pancreatic neuroendocrine tumors. Peripheral primitive neuroectodermal tumor (pPNET), paraganglioma (PGL) and epithelioid hemangioendothelioma (EHE) are rare tumors in which there is an overexpression of pro-angiogenic factors and in which a high intratumoral microvessel density is a significant poor prognostic factor. On the basis of this preclinical rationale and the lack of effective treatments in pre-treated advanced stages of these rare diseases, we report our interesting experience of pPNET, PGL and EHE treatment with sunitinib.
authors.affiliation: UO Oncologia, Fondazione Poliambulanza, Brescia, Mantua, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Prochilo
authors.forename: Giordano
authors.initials: G
authors.lastname: Savelli
authors.forename: Paola
authors.initials: P
authors.lastname: Bertocchi
authors.forename: Chiara
authors.initials: C
authors.lastname: Abeni
authors.forename: Luigina
authors.initials: L
authors.lastname: Rota
authors.forename: Anna
authors.initials: A
authors.lastname: Rizzi
authors.forename: Alberto
authors.initials: A
authors.lastname: Zaniboni
keywords: Antiangiogenic therapy; Epithelioid hemangioendothelioma; Paraganglioma; Peripheral primitive neuroectodermal tumor; Sunitinib