title: Amyloidosis: a clinical overview.
abstract: Amyloidosis is the name for protein-folding diseases characterized by extracellular deposition of a specific soluble precursor protein that aggregates in the form of insoluble fibrils. The classification of amyloidosis is based on the chemical characterization of the precursor protein. Deposition of amyloid is localized or systemic. The 4 main types of systemic amyloidosis are AL, AA, ATTR, and Aβ2M type. A schematic approach is proposed for the clinical management of systemic amyloidosis. The importance of typing amyloid with confidence, the usefulness of imaging techniques, the principles of treatment, and the need for well-planned treatment monitoring during follow-up are discussed.
authors.affiliation: Department of Rheumatology & Clinical Immunology, AA21, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. b.p.c.hazenberg@umcg.nl
authors.forename: Bouke P C
authors.initials: BP
authors.lastname: Hazenberg
mesh_terms: D000686:Amyloidosis / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D019468:Disease Management; D006801:Humans; D017510:Protein Folding; D000685:Serum Amyloid A Protein / Q000032:analysis* / Q000378:metabolism
chemical_list: D000685:Serum Amyloid A Protein