title: Does the time interval between antimüllerian hormone serum sampling and initiation of ovarian stimulation affect its predictive ability in in vitro fertilization-intracytoplasmic sperm injection cycles with a gonadotropin-releasing hormone antagonist? A retrospective single-center study.
abstract: OBJECTIVE
  To investigate whether the time interval between serum antimüllerian hormone (AMH) sampling and initiation of ovarian stimulation for in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) may affect the predictive ability of the marker for low and excessive ovarian response.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  University-based tertiary center.
  
  
  METHODS
  Five hundred and forty women with AMH values measured before their first IVF-ICSI cycle.
  
  
  METHODS
  Eligible patients treated with 150-225 IU recombinant follicle-stimulating hormone (FSH) in a gonadotropin-releasing hormone (GnRH) antagonist protocol.
  
  
  METHODS
  Predictive ability of AMH for low and excessive ovarian response in relation to the time interval between serum AMH sampling and initiation of ovarian stimulation for IVF-ICSI.
  
  
  RESULTS
  All patients had their AMH concentration measured up to 12 months before initiation of stimulation. The level of AMH demonstrated a statistically significant positive correlation with number of oocytes retrieved. The time interval between AMH measurement and initiation of stimulation had no influence on this correlation. The area under the receiver operator characteristic curve (ROC AUC) of AMH was high for both poor (0.72) and excessive response (0.80). The ROC regression analysis demonstrated that the time interval from sampling did not affect the performance of either poor response or excessive response prediction.
  
  
  CONCLUSIONS
  A time interval up to 12 months between AMH serum sampling and initiation of ovarian stimulation does not appear to affect the correlation between AMH level and the number of oocytes retrieved and the predictive ability of AMH to identify women at risk of low or excessive ovarian response.
authors.affiliation: Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium. n.polyzos@gmail.com
authors.forename: Nikolaos P
authors.initials: NP
authors.lastname: Polyzos
authors.forename: Scott M
authors.initials: SM
authors.lastname: Nelson
authors.forename: Dominic
authors.initials: D
authors.lastname: Stoop
authors.forename: Milie
authors.initials: M
authors.lastname: Nwoye
authors.forename: Peter
authors.initials: P
authors.lastname: Humaidan
authors.forename: Ellen
authors.initials: E
authors.lastname: Anckaert
authors.forename: Paul
authors.initials: P
authors.lastname: Devroey
authors.forename: Herman
authors.initials: H
authors.lastname: Tournaye
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000032:analysis / Q000097:blood*; D001800:Blood Specimen Collection; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D010062:Ovulation Induction; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods; D013997:Time Factors
chemical_list: D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; D054304:Anti-Mullerian Hormone
keywords: AMH; AMH variability; OHSS; excessive responders; ovarian response; poor responder; stimulation; time interval