title: Macular thickness measured by stratus optical coherence tomography in patients with diabetes type 2 and mild nonproliferative retinopathy without clinical evidence of macular edema.
abstract: To evaluate macular thickness in eyes with mild nonproliferative diabetic retinopathy (NPDR), patients with diabetes type 2, NPDR level 20 or 35, and without evidence of clinical macular edema underwent best-corrected visual acuity assessment, color fundus photography and Stratus optical coherence tomography. Mean center point thickness (CPT) and mean central subfield (CSF) thickness were compared with those of a healthy control population. 410 eyes/patients aged 61.2 ± 8.3 years, and with glycosylated hemoglobin of 7.9 ± 1.5% were included. Mean CPT and CSF were 186.6 ± 28.4 and 215.2 ± 25 µm, respectively, significantly increased compared to healthy subjects (p < 0.001). CSF thickness was abnormally increased in 17.6% of the patients, with values within the normal range in 79.5%, and abnormally decreased in 2.9%. CPT and CSF thickness were significantly thicker in men. No systemic factors showed a significant association. A significant increase in the macular thickness was found in eyes/patients with mild NPDR without clinical macular edema; however, only 17.6% of the eyes/patients had abnormally increased values and less than 3% abnormally decreased values.
authors.affiliation: Association for Innovation and Biomedical Research on Light and Image, PT- 3000-548 Coimbra, Portugal.
authors.forename: Isabel
authors.initials: I
authors.lastname: Pires
authors.forename: Ana Rita
authors.initials: AR
authors.lastname: Santos
authors.forename: Sandrina
authors.initials: S
authors.lastname: Nunes
authors.forename: Conceição
authors.initials: C
authors.lastname: Lobo
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis*; D003930:Diabetic Retinopathy / Q000175:diagnosis*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008269:Macular Edema / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D006442:Glycated Hemoglobin