title: A real-time colorimetric assay for label-free detection of microRNAs down to sub-femtomolar levels.
abstract: A real-time colorimetric assay utilizing gold nanoparticle networks and a duplex-specific nuclease (DSN) for label-free detection of microRNAs is proposed. Excellent sensitivity and selectivity were accomplished through the engagement of the DSN and a cumulative signal amplification process.
authors.affiliation: Department of Chemistry, National University of Singapore, Singapore 117543.
authors.forename: Wei
authors.initials: W
authors.lastname: Shen
authors.forename: Huimin
authors.initials: H
authors.lastname: Deng
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Ren
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Gao
mesh_terms: D003124:Colorimetry; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D035683:MicroRNAs / Q000032:analysis*
chemical_list: D035683:MicroRNAs; D006046:Gold