title: Epigenetic regulation of cardiac fibrosis.
abstract: Cardiac fibrosis is characterized by excessive extracellular matrix accumulation that ultimately destroys tissue architecture and eventually abolishes normal function. In recent years, despite the underlying mechanisms of cardiac fibrosis are still unknown, numerous studies suggest that epigenetic modifications impact on the development of cardiac fibrosis. Epigenetic modifications control cell proliferation, differentiation, migration, and so on. Epigenetic modifications contain three main processes: DNA methylation, histone modifications, and silencing by microRNAs. We here outline the recent work pertaining to epigenetic changes in cardiac fibrosis. This review focuses on the epigenetic regulation of cardiac fibrosis.
authors.affiliation: Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei 230601, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Tao
authors.forename: Kai-Hu
authors.initials: KH
authors.lastname: Shi
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Yang
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005355:Fibrosis / Q000235:genetics* / Q000473:pathology; D006657:Histones / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*
chemical_list: D006657:Histones; D035683:MicroRNAs