title: Barriers of clinical practice guidelines development and implementation in developing countries: a case study in iran.
abstract: BACKGROUND
  Knowledge products such as clinical practice guidelines (CPG) are vitally required for evidence-based medicine (EBM). Although the EBM, to some extent, has been attended during recent years, no result has achieved thus far. The current qualitative study is to identify the barriers to establishing development system and implementation of CPGs in Iran.
  
  
  METHODS
  Twelve semi-structured, in-depth interviews were conducted with a purposive sample of health policy and decision makers, the experts of development and or adaptation of CPGs, and the experts of EBM education and development. In addition, 11 policy-makers, decision-makers, and managers of the health system participated in a focus group discussion. The analysis of the study data was undertaken by thematic framework approach.
  
  
  RESULTS
  Six themes emerged in order of their frequency include practice environment, evidence-based health care system, individual professional, politician and political context, innovation (CPG) and patients. Most of the indications in the treatment environment focused on such sub-themes as regulations and rules, economical factors, organizational context, and social context. While the barriers related to the conditions of treatment environment, service provider and the features of innovation and patients had been identified before in other studies, very little attention has been paid to the evidence-based health care system and politician and political context.
  
  
  CONCLUSIONS
  The lack of an evidence-based healthcare system and a political macro support are mentioned as the key barriers in Iran as a developing country. The establishment of a system of development and implementation of CPGs as the evidence-based practice tools will not be possible, unless the barriers are removed.
authors.affiliation: School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Baradaran-Seyed
authors.forename: Sima
authors.initials: S
authors.lastname: Nedjat
authors.forename: Bahareh
authors.initials: B
authors.lastname: Yazdizadeh
authors.forename: Saharnaz
authors.initials: S
authors.lastname: Nedjat
authors.forename: Reza
authors.initials: R
authors.lastname: Majdzadeh
keywords: Barriers; clinical practice guideline; development; health care system; implementation; qualitative study