title: Five-year survival of alpha-fetoprotein-producing gastric cancer with synchronous liver metastasis: a case report.
abstract: Alpha-fetoprotein-Producing gastric cancer is associated with poor prognosis because of frequent liver and lymph node metastasis. We present a case with synchronous liver metastasis who survived for 5 years. A 69-year-old man with upper abdominal pain was referred to our hospital. Gastrointestinal endoscopy revealed a Borrmann II-like tumor in the lower part of the stomach. Computed tomography revealed a tumor in the left lobe of the liver. Serum alpha-fetoprotein levels were markedly increased. We performed distal gastrectomy after administering oral tegafur/gimeracil/oteracil potassium and administered hepatic intra-arterial cisplatin injection. Liver metastasis showed partial response on computed tomography. Despite left hepatic lobectomy, further metastases to the liver and mediastinal lymph nodes became difficult to control. After sorafenib tosylate administration, stabilization of the disease was observed for 4 months. We conclude that hepatic intra-arterial chemotherapy and oral administration of sorafenib tosylate may potentially improve the prognosis in such cases.
authors.affiliation: Department of Gastroenterological Surgery, University of Fukui, Fukui, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Koneri
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hirono
authors.forename: Daisuke
authors.initials: D
authors.lastname: Fujimoto
authors.forename: Katsuji
authors.initials: K
authors.lastname: Sawai
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Morikawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Murakami
authors.forename: Takanori
authors.initials: T
authors.lastname: Goi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Iida
authors.forename: Kanji
authors.initials: K
authors.lastname: Katayama
authors.forename: Akio
authors.initials: A
authors.lastname: Yamaguchi
keywords: Alpha-fetoproteins; Drug therapy; General surgery; Sorafenib; Stomach neoplasms