title: Kidney transplantation from hepatitis B (HB)-positive donors to HB negative recipients: anti-HB Core immunoglobulin G became positive in all recipients after the transplantation.
abstract: OBJECTIVE
  Hepatitis B surface antigen (HBsAg)-positive donors are not accepted by many transplant centers as a kidney source owing to risk of transmission of hepatitis B; however, some reports show that these donors can be used under a special protocol. Herein, we report our cases of kidney transplantation from HBsAg(+) donors to HbsAg(-) recipients.
  
  
  METHODS
  In the years 2010-2012, we transplanted 4 kidneys from 4 HBsAg(+) donors to HBsAg(-) recipients. They were all living related. All antiHBs(-) recipients were vaccinated before transplantation and became HBsAg(-), anti-HB core immunoglobulin G antibody negative [antiHBcIg(-)], and antiHBs(+). Pretransplantation antiHBs titers were targeted to be >100 IU. If lower, hepatitis B Ig was used at the time of transplantation. One patient received hepatitis B Ig at the time of transplantation (owing to titer of 62 IU/L antiHBs). Lamivudine was prescribed for all kidney allograft recipients after transplantation.
  
  
  RESULTS
  Two patients had special induction treatment including rituximab, intravenous immunoglobulin, and plasmapheresis owing to the presence of donor-specific antibody.
  
  
  CONCLUSIONS
  All patients became antiHBcIgG(+) at 1-6 months after the transplantation, despite the presence of antiHBs positivity, which might be explained by transmission of hepatitis B virus through the graft.
authors.affiliation: Department of Nephrology, Ankara University School of Medicine, Ankara, Turkey. zeynepkendi@yahoo.com
authors.forename: Z K
authors.initials: ZK
authors.lastname: Celebi
authors.forename: S
authors.initials: S
authors.lastname: Sengul
authors.forename: Z
authors.initials: Z
authors.lastname: Soypacaci
authors.forename: O
authors.initials: O
authors.lastname: Yayar
authors.forename: R
authors.initials: R
authors.lastname: Idilman
authors.forename: A
authors.initials: A
authors.lastname: Tuzuner
authors.forename: K
authors.initials: K
authors.lastname: Keven
mesh_terms: D000328:Adult; D005260:Female; D006509:Hepatitis B; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D014019:Tissue Donors; D014758:Viral Core Proteins / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D014758:Viral Core Proteins