title: Apoptosis in cultured renal epithelial cells caused by ochratoxin A.
abstract: Apoptosis induction in renal epithelial cells caused by exposure to ochratoxin A (OTA) was studied. Nanomolar concentrations of OTA led to activation of caspase 3 with subsequent chromatin condensation and DNA ladder formation, both characteristic for cells undergoing apoptosis. Inhibition of the mitochondrial ATP/ADP carrier prevented OTA induced caspase activation showing that intact mitochondria are necessary for OTA induced apoptosis.
authors.affiliation: Physiologisches Institut, Universität Würzburg, Röntgenring 9, 97070, Würzburg, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Schwerdt
authors.forename: R
authors.initials: R
authors.lastname: Freudinger
authors.forename: C
authors.initials: C
authors.lastname: Schuster
authors.forename: S
authors.initials: S
authors.lastname: Silbernagl
authors.forename: M
authors.initials: M
authors.lastname: Gekle