title: [Role of genetic and environmental factors in the development of polycystic ovary syndrome].
abstract: Polycystic ovary syndrome is the most common heterogeneous endocrine abnormality in women in the reproductive age. The syndrome remains an enigmatic disorder because the aetiology is still unclear. Familial aggreagation is relatively common among patients with polycystic ovary syndrome suggesting a signiﬁcant genetic component, although the way of inheritance has not been established firmly. The authors review the relevant medical literature and suggest that genetic and environmental factors play a role in the development of polycystic ovary syndrome. To date, no gene has been identified that causes or contributes substantially to the development of a polycystic ovary syndrome phenotype. Polycystic ovarian syndrome is considered to be an oligogenic disorder in which the interaction of a number of genetic and environmental factors determines the heterogeneous clinical and biochemical phenotype. To summarize current evidence the authors conclude, that when we are able to identify and then modify environmental determinants, then we will be able to safeguard better the health of those patients who are predisposed to disease development due to genotype or previous environmental effects.
authors.affiliation: Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház Csecsemő- és Gyermekosztály, Miskolc, Szentpéteri kapu 72-76. 3524. Miskolci Egyetem, Egészségügyi Kar, Preventív Egészségtudományi Tanszék, Miskolc. sagodilaszlo@gmail.com
authors.forename: László
authors.initials: L
authors.lastname: Ságodi
authors.forename: Emőke
authors.initials: E
authors.lastname: Kiss-Tóth
authors.forename: László
authors.initials: L
authors.lastname: Barkai
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D042241:Early Diagnosis; D004777:Environment; D044127:Epigenesis, Genetic; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications / Q000209:etiology; D006946:Hyperinsulinism / Q000150:complications* / Q000209:etiology; D007333:Insulin Resistance / Q000235:genetics; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000235:genetics / Q000473:pathology / Q000503:physiopathology
chemical_list: D015415:Biomarkers