title: First regiocontrolled synthesis of procyanidin B6, a catechin dimer with rare connectivity: a halo-capping strategy for formation of 4,6-interflavan bonds.
abstract: The first regiocontrolled synthesis of procyanidin B6, a dimer with a rare 4,6-interflavan linkage, is described. Regioselective linking was achieved by the halo-capping strategy followed by removal of all the benzyl protecting groups and the halo-caps by one-pot hydrogenolysis.
authors.affiliation: Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.
authors.forename: Gen
authors.initials: G
authors.lastname: Watanabe
authors.forename: Ken
authors.initials: K
authors.lastname: Ohmori
authors.forename: Keisuke
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D044946:Biflavonoids / Q000138:chemical synthesis* / Q000737:chemistry; D002392:Catechin / Q000138:chemical synthesis* / Q000737:chemistry; D019281:Dimerization; D054879:Halogenation; D044945:Proanthocyanidins / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D044946:Biflavonoids; D044945:Proanthocyanidins; C017674:procyanidin; D002392:Catechin