title: Antihypertensive and hypolipidemic effect of milk fermented by specific Lactococcus lactis strains.
abstract: The antihypertensive and hypolipidemic effects of milk fermented by specific Lactococcus lactis strains in spontaneously hypertensive rats (SHR) were investigated. The SHR were fed ad libitum milk fermented by Lc. lactis NRRL B-50571, Lc. lactis NRRL B-50572, Captopril (40mg/kg of body weight, Sigma-Aldrich Co., St. Louis, MO) or purified water for 4 wk. Results suggested that Lc. lactis fermented milks presented a significant blood pressure-lowering effect. No significant difference was noted among milk fermented by Lc. lactis NRRL B-50571 and Captopril by the second and third week of treatment. Additionally, milk fermented by Lc. lactis strains modified SHR lipid profiles. Milk fermented by Lc. lactis NRRL B-50571 and B-50572 were able to reduce plasma low-density lipoprotein cholesterol and triglyceride contents. Thus, milk fermented by Lc. lactis strains may be a coadjuvant in the reduction of hypertension and hyperlipidemia and may be used as a functional food for better cardiovascular health.
authors.affiliation: Laboratorio de Química y Biotecnología de Productos Lácteos, Coordinación de Tecnología de Alimentos de Origen Animal, Centro de Investigación en Alimentación y Desarrollo A.C. (CIAD), Carretera a La Victoria Km. 0.6 Hermosillo, Sonora 83304, Mexico.
authors.forename: J C
authors.initials: JC
authors.lastname: Rodríguez-Figueroa
authors.forename: A F
authors.initials: AF
authors.lastname: González-Córdova
authors.forename: H
authors.initials: H
authors.lastname: Astiazaran-García
authors.forename: A
authors.initials: A
authors.lastname: Hernández-Mendoza
authors.forename: B
authors.initials: B
authors.lastname: Vallejo-Cordoba
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure; D043302:Cultured Milk Products / Q000737:chemistry; D005285:Fermentation; D006973:Hypertension / Q000628:therapy; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D013294:Lactococcus lactis / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008297:Male; D008892:Milk / Q000737:chemistry / Q000378:metabolism* / Q000382:microbiology*; D051381:Rats; D011918:Rats, Inbred SHR; D014280:Triglycerides / Q000097:blood
chemical_list: D000959:Antihypertensive Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D014280:Triglycerides