title: What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?
abstract: Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by a large number of physical and chemical stimuli, which involves them with sensory cell physiology. The vanilloid TRP subfamily (TRPV) named after the vanilloid receptor 1 (TRPV1) consists of six members, and at least four of them (TRPV1-TRPV4) have been related to thermal sensation. One of the least characterized members of the TRP subfamily is TRPV2. Although initially characterized as a noxious heat sensor, TRPV2 now seems to have little to do with temperature sensing but a much more complex physiological profile. Here we review the available information and research progress on the structure, physiology and pharmacology of TRPV2 in an attempt to shed some light on the physiological and pharmacological deorphanization of TRPV2.
authors.affiliation: Centre d'Estudis en Biofísica, Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Spain.
authors.forename: Alex
authors.initials: A
authors.lastname: Perálvarez-Marín
authors.forename: Pau
authors.initials: P
authors.lastname: Doñate-Macian
authors.forename: Rachelle
authors.initials: R
authors.lastname: Gaudet
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000737:chemistry / Q000378:metabolism*; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D058990:Molecular Targeted Therapy; D050916:TRPV Cation Channels / Q000737:chemistry / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D002316:Cardiotonic Agents; D050916:TRPV Cation Channels; C400769:TRPV2 protein, human; C485717:Trpv2 protein, mouse
keywords: TRPV2; calcium signalling; cancer; endocrinology; immunology; ion channels; muscle physiology; neuroscience; pharmacology; somatosensation