title: Serum salusin-α levels are inversely correlated with the presence and severity of coronary artery disease.
abstract: We sought to measure serum salusin-α levels in patients with coronary artery disease (CAD) and to assess their correlation with the severity of the disease. We enrolled 172 patients with CAD and 91 controls. We assessed the angiographic severity of CAD by coronary atherosclerosis index (CAI) and detected serum salusin-α levels by enzyme-linked immunosorbent assay (ELISA). We demonstrated that CAD patients had significantly lower serum salusin-α levels compared to controls. Moreover, serum salusin-α levels were independently and negatively correlated with the presence and severity of CAD. These findings indicated that salusin-α might serve as a potential biomarker for predicting the development and progression of CAD.
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery, Nanfang Hospital of Southern Medical University , Guangzhou, Guangdong, P. R. China.
authors.forename: Song-Lin
authors.initials: SL
authors.lastname: Du
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery, Nanfang Hospital of Southern Medical University , Guangzhou, Guangdong, P. R. China.
authors.forename: Wu-Jun
authors.initials: WJ
authors.lastname: Wang
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery, Nanfang Hospital of Southern Medical University , Guangzhou, Guangdong, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wan
authors.affiliation: b Department of Cardiology, Nanfang Hospital of Southern Medical University , Guangzhou, Guangdong, P. R. China.
authors.forename: Yue-Gang
authors.initials: YG
authors.lastname: Wang
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery, Nanfang Hospital of Southern Medical University , Guangzhou, Guangdong, P. R. China.
authors.forename: Zhen-Kang
authors.initials: ZK
authors.lastname: Wang
authors.affiliation: a Department of Thoracic and Cardiovascular Surgery, Nanfang Hospital of Southern Medical University , Guangzhou, Guangdong, P. R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins; D010446:Peptide Fragments; C478739:TOR2A protein, human; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein
keywords: Disease; biological factors; cardiovascular; coronary artery disease; salusin-α