title: The antioxidant activities and neuroprotective effect of polysaccharides from the starfish Asterias rollestoni.
abstract: After the starfish was defatted with isopropyl alcohol and ethanol, crude polysaccharide was extracted by 0.15 mol/L HCl. Anion exchange chromatography was performed to fractionate the sample into two fractions, SF-1 and SF-2. Chemical analysis showed that the major component of SF-1 was a glucan consisting of a backbone of 1→3 linked β-D-glucopyranose residues, and it had a minor glucan component containing a backbone of 1→3 linked α-D-glucopyranose residues. SF-2 was a mannoglucan sulfate. SF-2 displayed the highest antioxidant activity among the polysaccharides. Moreover, SF-1 and SF-2 exhibited neuroprotective activities in a neurotoxicity model of Parkinson's disease (PD).
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Weihua
authors.initials: W
authors.lastname: Jin
authors.forename: Quanbin
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005609:Free Radicals / Q000737:chemistry; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016627:Oxidopamine; D010300:Parkinson Disease / Q000188:drug therapy; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013215:Starfish
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D018696:Neuroprotective Agents; D011134:Polysaccharides; D016627:Oxidopamine