title: Photoswitchable particles for on-demand degradation and triggered release.
abstract: On-demand degradable polymer particles are fabricated via electrospraying of a solution of acetal-protected dextran that further includes 2-(4-methoxystyryl)-4,6-bis(trichloromethyl)-1,3,5-triazine as a photoacid generator. The illumination of UV light gives rise to photoacid and activates the catalytic deprotection of hydroxyl groups of dextran, leading to controlled dissolution of the microparticles in water.
authors.affiliation: Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Tae-Hong
authors.initials: TH
authors.lastname: Park
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Eyster
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Lumley
authors.forename: Sangyeul
authors.initials: S
authors.lastname: Hwang
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Lee
authors.forename: Asish
authors.initials: A
authors.lastname: Misra
authors.forename: Sahar
authors.initials: S
authors.lastname: Rahmani
authors.forename: Joerg
authors.initials: J
authors.lastname: Lahann
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D011108:Polymers
keywords: biopolymers; drug delivery; electrospinning; nanoparticles; photoswitching