title: Systolic blood pressure and mortality in chronic hemodialysis patients: results of a nationwide italian study.
abstract: Studies on the relationship between blood pressure (BP) and mortality among hemodialysis patients have yielded conflicting results. Reports have come mostly from North America and have dealt with dialysis patients as a homogenous population and differed in methods and time of BP measurement and the optimal BP target. In a prospective nationwide study in 3674 unselected Caucasian patients with end-stage renal disease undergoing chronic hemodialysis from 73 dialysis units, the authors sought to examine the relationship between the different measurements of BP and mortality according to antihypertensive treatment. The mean age of patients was 67.2±14.1 years and the prevalence of diabetes was 19.5%. During follow-up (26.5±10.5 months), 977 deaths were recorded. In the whole cohort, BP was not associated with mortality. After grouping the patients according to antihypertensive treatment, the analysis showed that only in patients who did not take antihypertensive medications (1613) was there an inverse relationship between postdialysis systolic BP and mortality. These patients differed from the others in BP, dialysis vintage, prevalence of diabetes, and type of dialysis technique. This study suggests that with respect to the relationship of BP with mortality, dialysis patients are not a homogenous population. Differences in demographic characteristics and in dialysis technique may therefore explain the reported variability of previous results.
authors.affiliation: Ospedale Santa Maria Della Misericordia, Perugia, Italy. atlosito@tin.it
authors.forename: Attilio
authors.initials: A
authors.lastname: Losito
authors.forename: Lucia
authors.initials: L
authors.lastname: Del Vecchio
authors.forename: Tiziano
authors.initials: T
authors.lastname: Lusenti
authors.forename: Goffredo
authors.initials: G
authors.lastname: Del Rosso
authors.forename: Rosella
authors.initials: R
authors.lastname: Malandra
authors.forename: Alessandra
authors.initials: A
authors.lastname: Sturani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy; D007676:Kidney Failure, Chronic / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D006435:Renal Dialysis
chemical_list: D000959:Antihypertensive Agents