title: Rapidly stopping hemorrhage by enhancing blood clotting at an opened wound using chitosan/polylactic acid/polycaprolactone wound dressing device.
abstract: Doxycycline and monosodium glutamate (MSG) loaded chitosan (CHI)/polylactic acid (PLA)/polycaprolactone (PCL) blend film was studied as a model device to deliver drug to targeted human organ which in this case was the skin with opened wound. The CHI/PLA/PCL blend film containing 60 % CHI, 28 % PLA, and 12 % PCL exhibited the good properties for making the dressing device. It was observed that doxycycline/MSG loaded CHI/PLA/PCL blend film could rapidly deliver both doxycycline and MSG at the high release percentage approaching 100 % loaded. MSG accelerated blood clotting and fibrin formation; thus, it exhibited the good hemostatic activity. The antibacterial activity of doxycycline loaded CHI/PLA/PCL blend film against Staphylococcus aureus and Escherichia coli as model bacteria was investigated. Doxycycline release played the crucial role in bacterial inhibition as observed from the lowest bacterial cell dry weight observed when compared with the control bacterial culture or the bacterial cultures with the presence of other films studied.
authors.affiliation: Program in Petrochemistry and Polymer Science, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Wasinee
authors.initials: W
authors.lastname: Boonkong
authors.forename: Amorn
authors.initials: A
authors.lastname: Petsom
authors.forename: Nuttha
authors.initials: N
authors.lastname: Thongchul
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001424:Bacterial Infections / Q000188:drug therapy; D001458:Bandages; D001777:Blood Coagulation / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D004318:Doxycycline / Q000008:administration & dosage*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D004867:Equipment Design; D006490:Hemostatics / Q000008:administration & dosage; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D019106:Postoperative Hemorrhage / Q000628:therapy*; D012970:Sodium Glutamate / Q000008:administration & dosage*; D013530:Surgical Wound Infection / Q000188:drug therapy; D016896:Treatment Outcome; D058106:Wound Closure Techniques / Q000295:instrumentation
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D006490:Hemostatics; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; D019344:Lactic Acid; C033616:poly(lactide); D048271:Chitosan; D004318:Doxycycline; D012970:Sodium Glutamate