title: [Innovative therapeutic strategies for intravesical drug administration].
abstract: BACKGROUND
  Perspectives for innovative pharmaceutical molecules and intravesical administration of pharmacological agents are presented in the present review carried out from a recent literature.
  
  
  METHODS
  This review of the literature was built by using the PubMed and ScienceDirect databases running 20keywords revealing 34publications between 1983 and 2012. The number of referenced articles on ScienceDirect has increased in recent years, highlighting the interest of scientists for intravesical drug administration and the relevance of innovating drug delivery systems.
  
  
  RESULTS
  Different modalities of intravesical administration using physical (e.g., iontophoresis, electroporation) or chemical techniques (e.g., enzyme, solvent, nanoparticles, liposomes, hydrogels) based on novel formulation methods are reported. Finally, the development of biopharmaceuticals (e.g., bacillus Calmette-Guérin, interferon α) and gene therapies is also presented and analyzed in this review.
  
  
  CONCLUSIONS
  The present review exhibits new development in the pipeline for emerging intravesical drug administration strategies. Knowledge of all these therapies allows practitioners to propose a specific and tailored treatment to each patient with limiting systemic side effects.
authors.affiliation: Service pharmaceutique, fabrication et contrôle des médicaments, Pavillon X, groupement hospitalier Édouard-Herriot, hospices civils de Lyon, 5, place d'Arsonval, 69437 Lyon cedex 03, France.
authors.forename: C
authors.initials: C
authors.lastname: Moch
authors.forename: D
authors.initials: D
authors.lastname: Salmon
authors.forename: P
authors.initials: P
authors.lastname: Rome
authors.forename: R
authors.initials: R
authors.lastname: Marginean
authors.forename: C
authors.initials: C
authors.lastname: Pivot
authors.forename: M
authors.initials: M
authors.lastname: Colombel
authors.forename: F
authors.initials: F
authors.lastname: Pirot
mesh_terms: D000283:Administration, Intravesical; D004358:Drug Therapy / Q000379:methods; D006801:Humans; D001745:Urinary Bladder Diseases / Q000188:drug therapy*