title: Hemodialysis for the treatment of pulmonary hemorrhage from dabigatran overdose.
abstract: Dabigatran is an oral direct thrombin inhibitor indicated for thromboembolism prophylaxis in patients with nonvalvular atrial fibrillation. Since its approval in the United States in 2010, dabigatran-associated hemorrhages have garnered much attention because bleeding rates were higher than initially expected. Additionally, reversing anticoagulation remains challenging. Traditional modes of reversing warfarin-associated coagulopathies are ineffective in reversing anticoagulation from dabigatran. Although hemodialysis is proposed as a method to accelerate dabigatran elimination, evidence supporting its clinical utility remains unproved. We report the case of an 80-year-old man who presented with worsening hemoptysis in the setting of unintentional ingestion of excess dabigatran. Despite transfusion of 2 units of fresh frozen plasma, he continued to bleed, although his international normalized ratio improved from 8.8 to 7.2. He underwent hemodialysis, and serum dabigatran concentration decreased from 1,100 to 18 ng/mL over 4 hours, with an initial extraction ratio of 0.97 and blood clearance of 291 mL/min. Although his serum dabigatran concentration rebounded to 100 ng/mL 20 minutes after the cessation of dialysis, his bleeding stopped and he improved clinically. Hemorrhage in the setting of dabigatran anticoagulation remains a therapeutic predicament. Hemodialysis may play an adjunct role in accelerating the elimination of dabigatran in bleeding patients.
authors.affiliation: New York City Poison Control Center, New York University School of Medicine, Bellevue Hospital Center, New York, NY, USA. betty.chen@nyumc.org
authors.forename: Betty C
authors.initials: BC
authors.lastname: Chen
authors.forename: Nijal R
authors.initials: NR
authors.lastname: Sheth
authors.forename: Kobena A
authors.initials: KA
authors.lastname: Dadzie
authors.forename: Silas W
authors.initials: SW
authors.lastname: Smith
authors.forename: Lewis S
authors.initials: LS
authors.lastname: Nelson
authors.forename: Robert S
authors.initials: RS
authors.lastname: Hoffman
authors.forename: James F
authors.initials: JF
authors.lastname: Winchester
mesh_terms: D000369:Aged, 80 and over; D000991:Antithrombins / Q000009:adverse effects* / Q000097:blood; D001562:Benzimidazoles / Q000009:adverse effects* / Q000097:blood; D000069604:Dabigatran; D006470:Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D006435:Renal Dialysis / Q000379:methods; D016896:Treatment Outcome; D015091:beta-Alanine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D000991:Antithrombins; D001562:Benzimidazoles; D015091:beta-Alanine; D000069604:Dabigatran
keywords: Dabigatran; Pradaxa; dialysis; overdose