title: Tuberous sclerosis complex associated with heterotopic ossification in a young girl.
abstract: Tuberous sclerosis complex (TSC) is a multisystem disorder resulting in hamartomatous lesions. Despite diverse manifestations, skeletal muscular comorbidity is rarely reported in TSC. We report a 2-year-old girl with TSC who suffered from multiple subcutaneous masses over the paraspinal and bilateral scapular areas, which caused disabling pain on any passive movement. Three-dimensional computed tomography scanning revealed multiple calcifications that were consequently diagnosed as fibrodysplasia ossificans progressiva. Such imaging features should be evaluated cautiously to avoid unnecessary surgical intervention and biopsy that may worsen the condition.
authors.affiliation: Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Teck-King
authors.initials: TK
authors.lastname: Tan
authors.affiliation: Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Fong-Lin
authors.initials: FL
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Ji-Nan
authors.initials: JN
authors.lastname: Sheu
authors.affiliation: Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Shan-Ming
authors.initials: SM
authors.lastname: Chen
authors.affiliation: Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Hsin-Hui
authors.initials: HH
authors.lastname: Huang
authors.affiliation: Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan. Electronic address: fernand.tsai@msa.hinet.net.
authors.forename: Jeng-Dau
authors.initials: JD
authors.lastname: Tsai
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D009221:Myositis Ossificans / Q000209:etiology*; D009999:Ossification, Heterotopic / Q000209:etiology*; D014402:Tuberous Sclerosis / Q000150:complications*
keywords: fibrodysplasia ossificans progressive; heterotopic ossificans; tuberous sclerosis complex