title: Prevalence of Yersinia enterocolitica in antimicrobial-free and conventional antimicrobial use swine production.
abstract: Swine are the primary reservoir for foodborne illness associated with Yersinia enterocolitica. The use of antimicrobials in animal agriculture has been hypothesized as having a potential role in the increase in prevalence of zoonotic pathogens. The objective of this study was to compare the frequency of Y. enterocolitica fecal shedding in swine reared on farms with conventional antimicrobial use policies to farms that were antimicrobial free (ABF). Swine farms were selected from three regions in the United States. In each region, farms were categorized based on antimicrobial use policy. Fecal samples were collected from pigs on-farm within 48 h of harvest. The overall proportion of Y. enterocolitica and ail-harboring Y. enterocolitica-positive pigs was 10.9% and 4.0%, respectively. There were increased odds (odds ratio [OR] 6.8, 95% confidence interval [CI] 3.46-13.28) for a pig to be Y. enterocolitica positive if it was reared on an ABF farm as compared to a conventional farm. There was no significant association between farm antimicrobial use policy and isolation of an ail-harboring Y. enterocolitica from an individual pig (OR 1.8, 95% CI 0.90-3.61). The association of antimicrobial use policy with Y. enterocolitica shedding in feces should be interpreted cautiously, as antimicrobial use cannot be separated from other management factors (e.g., confinement or outdoor housing), which may be associated with risk of Y. enterocolitica in swine.
authors.affiliation: Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA. funkj@cvm.msu.edu
authors.forename: Julie A
authors.initials: JA
authors.lastname: Funk
authors.forename: Melanie J
authors.initials: MJ
authors.lastname: Abley
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Bowman
authors.forename: Wondwossen A
authors.initials: WA
authors.lastname: Gebreyes
authors.forename: William E Morgan
authors.initials: WE
authors.lastname: Morrow
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Tadesse
mesh_terms: D000822:Animal Husbandry / Q000379:methods*; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism; D057138:Bacterial Shedding / Q000187:drug effects; D015415:Biomarkers / Q000378:metabolism; D005243:Feces / Q000382:microbiology; D005517:Foodborne Diseases / Q000517:prevention & control; D006801:Humans; D015146:Midwestern United States; D058889:Molecular Typing; D009657:North Carolina; D012703:Serotyping; D034421:Sus scrofa / Q000382:microbiology*; D015009:Yersinia Infections / Q000517:prevention & control; D015008:Yersinia enterocolitica / Q000145:classification / Q000254:growth & development* / Q000302:isolation & purification / Q000378:metabolism
chemical_list: C069712:Ail protein, Yersinia enterocolitica; D000890:Anti-Infective Agents; D001425:Bacterial Outer Membrane Proteins; D015415:Biomarkers