title: Acquisition of CD30 and CD15 accompanied with simultaneous loss of all pan-T-cell antigens in a case of histological transformation of mycosis fungoides with involvement of regional lymph node: an immunophenotypic alteration resembling classical Hodgkin lymphoma.
abstract: : Acquired expression of CD30 is frequently noted in histological transformation of mycosis fungoides (MF), but simultaneous gain of CD15 accompanied with loss of pan-T-cell antigens are extremely rare. We report an unusual case of transformed MF with such an immunophenotypic alteration resembling classical Hodgkin lymphoma. The patient was an 81-year-old male with MF, who was initially treated with topical steroids and phototherapy. Despite the initial response, the patient developed a tumor-like skin lesion that was confirmed to be CD30-positive large T-cell lymphoma and was subsequently found to have a regional lymph node involvement by pleomorphic large cell lymphoma. Besides CD30, pleomorphic large cells were positive for CD15 but negative for all B cell- and T cell-specific antigens. Epstein-Barr virus was negative. Polymerase chain reaction-based assays demonstrated a clonal rearrangement of T-cell receptor gamma gene but detected no B-cell clone. The mechanism and clinical significance of this phenotypic conversion remains to be elucidated.
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, NC.
authors.forename: Deepti M
authors.initials: DM
authors.lastname: Reddi
authors.forename: Siby
authors.initials: S
authors.lastname: Sebastian
authors.forename: Endi
authors.initials: E
authors.lastname: Wang
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005647:Fucosyltransferases / Q000096:biosynthesis; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D016130:Immunophenotyping; D017730:Ki-1 Antigen / Q000096:biosynthesis; D016256:Lewis X Antigen / Q000096:biosynthesis; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000473:pathology; D008297:Male; D009182:Mycosis Fungoides / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D017730:Ki-1 Antigen; D016256:Lewis X Antigen; C066693:FUT4 protein, human; D005647:Fucosyltransferases