title: Viral infectivity factor: a novel therapeutic strategy to block HIV-1 replication.
abstract: The HIV-1 viral infectivity factor (Vif), one of the six accessory proteins, is essential for viral replication and pathogenesis. Its main function is to form Vif-Cullin5-ElonginBC complex and then is able to ubiquitinate and degrade the human anti-viral factor APOBEC3G, which markedly enhances the virus infectivity. Delete Vif leads to the loss of the infectivity of HIV-1; therefore, Vif is a potentially new attractive target for therapeutic intervention in AIDS. This review describes the structure, function and especially inhibitors of HIV-1 Vif.
authors.affiliation: Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, College of Chemistry and Life Science, Huanggang Normal University, No. 146, Xingang 2 Road, Huanggang 438000, Hubei, P.R. China. guliang_yang@163.com
authors.forename: Guliang
authors.initials: G
authors.lastname: Yang
authors.forename: Xujie
authors.initials: X
authors.lastname: Xiong
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000254:growth & development* / Q000378:metabolism; D006801:Humans; D014779:Virus Replication / Q000187:drug effects*; D054320:vif Gene Products, Human Immunodeficiency Virus / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D019380:Anti-HIV Agents; D054320:vif Gene Products, Human Immunodeficiency Virus