title: Estrogen receptor- and progesterone receptor-positive diffuse sclerosing variant of papillary thyroid carcinoma: a case report.
abstract: The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is a relatively rare tumor. We herein report the case of young woman with DSV-PTC who developed cervical lymph node recurrence 7 years after the initial surgery. A 15-year-old female patient with no medical or family history of thyroid tumors developed a thyroid neoplasm in the right lobe. Right thyroidectomy and regional lymphadenectomy were performed, and the tumor was diagnosed as DSV-PTC. She was followed up as an outpatient. Seven years after the surgery, cervical lymph node recurrence developed. On microscopic examination, the thyroid tumor showed a papillary growth pattern with numerous psammoma bodies and distinct fibrosis. Immunohistochemically, the tumor cells were estrogen receptor and progesterone receptor positive with reduced membranous expression of E-cadherin and were intermingled with S-100-positive dendritic/Langerhans cells. DSV-PTC is characterized by a strong tendency for invasion and metastasis. Thus, accurate diagnosis is clinically important, and a morphological and immunohistochemical understanding of DSV-PTC is necessary.
authors.affiliation: Department of Pathology II, Kansai Medical University, Amagasaki, Japan ; Division of Diagnostic Cytopathology and Histopathology, Kansai Medical University Takii Hospital, Moriguchi, Amagasaki, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Kosho
authors.initials: K
authors.lastname: Takasu
authors.forename: Takashi
authors.initials: T
authors.lastname: Yuri
authors.forename: Kastuhiko
authors.initials: K
authors.lastname: Yoshizawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Emoto
authors.forename: Airo
authors.initials: A
authors.lastname: Tsubura
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Shikata
keywords: Diffuse sclerosing variant of papillary thyroid carcinoma; E-cadherin; Estrogen receptor; Immunohistochemistry; Progesterone receptor; S-100