title: [The Notch signaling system and oncogenesis].
abstract: Current approaches to treatment of malignant tumors are rather close to an achievement of their limit. One of the new trends of treatment is target therapy based on intended influence on any molecular target. At the present time the most precise attention is paid to receptors and signaling systems that take part in regulation of the main vital processes of cells: proliferation, apoptosis, neoangiogenesis. One of possible variants of target therapy could be action on to signaling system Notch. Contemporary reference data show a link between this intracellular way of signal transmission and regulation of proliferation, differentiation and apoptosis of tumor cells.
authors.forename: A N
authors.initials: AN
authors.lastname: Aleĭnik
authors.forename: I V
authors.initials: IV
authors.lastname: Kondakova
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents; D051880:Receptors, Notch