title: Predictors of long-term survival in patients with glioblastoma multiforme: advancements from the last quarter century.
abstract: Over the last quarter century there has been significant progress toward identifying certain characteristics and patterns in GBM patients to predict survival times and outcomes. We sought to identify clinical predictors of survival in GBM patients from the past 24 years. We examined patient survival related to tumor locations, surgical treatment, postoperative course, radiotherapy, chemotherapy, patient age, GBM recurrence, imaging characteristics, serum, and molecular markers. We present predictors that may increase, decrease, or play no significant role in determining a GBM patient's long-term survival or affect the quality of life.
authors.affiliation: Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
authors.forename: Nauman S
authors.initials: NS
authors.lastname: Chaudhry
authors.forename: Ashish H
authors.initials: AH
authors.lastname: Shah
authors.forename: Nicholas
authors.initials: N
authors.lastname: Ferraro
authors.forename: Brian M
authors.initials: BM
authors.lastname: Snelling
authors.forename: Amade
authors.initials: A
authors.lastname: Bregy
authors.forename: Karthik
authors.initials: K
authors.lastname: Madhavan
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Komotar
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D001932:Brain Neoplasms / Q000097:blood / Q000235:genetics / Q000401:mortality* / Q000628:therapy; D003131:Combined Modality Therapy; D005909:Glioblastoma / Q000097:blood / Q000235:genetics / Q000401:mortality* / Q000628:therapy; D006801:Humans; D009154:Mutation; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011379:Prognosis; D012307:Risk Factors; D017741:Survivors
chemical_list: D014408:Biomarkers, Tumor