title: The American Brachytherapy Society consensus statement for accelerated partial breast irradiation.
abstract: OBJECTIVE
  To develop clinical guidelines for the quality practice of accelerated partial breast irradiation (APBI) as part of breast-conserving therapy for women with early-stage breast cancer.
  
  
  METHODS
  Members of the American Brachytherapy Society with expertise in breast cancer and breast brachytherapy in particular devised updated guidelines for appropriate patient evaluation and selection based on an extensive literature search and clinical experience.
  
  
  RESULTS
  Increasing numbers of randomized and single and multi-institution series have been published documenting the efficacy of various APBI modalities. With more than 10-year followup, multiple series have documented excellent clinical outcomes with interstitial APBI. Patient selection for APBI should be based on a review of clinical and pathologic factors by the clinician with particular attention paid to age (≥50 years old), tumor size (≤3cm), histology (all invasive subtypes and ductal carcinoma in situ), surgical margins (negative), lymphovascular space invasion (not present), and nodal status (negative). Consistent dosimetric guidelines should be used to improve target coverage and limit potential for toxicity following treatment.
  
  
  CONCLUSIONS
  These guidelines have been created to provide clinicians with appropriate patient selection criteria to allow clinicians to use APBI in a manner that will optimize clinical outcomes and patient satisfaction. These guidelines will continue to be evaluated and revised as future publications further stratify optimal patient selection.
authors.affiliation: Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO, USA.
authors.forename: Chirag
authors.initials: C
authors.lastname: Shah
authors.forename: Frank
authors.initials: F
authors.lastname: Vicini
authors.forename: David E
authors.initials: DE
authors.lastname: Wazer
authors.forename: Douglas
authors.initials: D
authors.lastname: Arthur
authors.forename: Rakesh R
authors.initials: RR
authors.lastname: Patel
mesh_terms: D000367:Age Factors; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001918:Brachytherapy / Q000379:methods* / Q000592:standards*; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000628:therapy; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D017060:Patient Satisfaction; D017410:Practice Guidelines as Topic; D012955:Societies, Medical; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen