title: Coating of titanium with hydroxyapatite leads to decreased bone formation: A study in rabbits.
abstract: OBJECTIVE
  An experimental rabbit model was used to test the null hypothesis, that there is no difference in new bone formation around uncoated titanium discs compared with coated titanium discs when implanted into the muscles of rabbits.
  
  
  METHODS
  A total of three titanium discs with different surface and coating (1, porous coating; 2, porous coating + Bonemaster (Biomet); and 3, porous coating + plasma-sprayed hydroxyapatite) were implanted in 12 female rabbits. Six animals were killed after six weeks and the remaining six were killed after 12 weeks. The implants with surrounding tissues were embedded in methyl methacrylate and grinded sections were stained with Masson-Goldners trichrome and examined by light microscopy of coded sections.
  
  
  RESULTS
  Small amounts of bone were observed scattered along the surface of five of the 12 implants coated with porous titanium, and around one out of 12 porous coated surfaces with Bonemaster. No bone formation could be detected around porous coated implants with plasma-sprayed hydroxyapatite.
  
  
  CONCLUSIONS
  Porous titanium coating is to some degree osteoinductive in muscles.
authors.affiliation: Vestre Viken HF, Ringerike Hospital, Postboks 3024, 3501 Hønefoss, Norway.
authors.forename: B G
authors.initials: BG
authors.lastname: Bøe
authors.forename: R Ø
authors.initials: RØ
authors.lastname: Støen
authors.forename: L B
authors.initials: LB
authors.lastname: Solberg
authors.forename: F P
authors.initials: FP
authors.lastname: Reinholt
authors.forename: J E
authors.initials: JE
authors.lastname: Ellingsen
authors.forename: L
authors.initials: L
authors.lastname: Nordsletten
keywords: Bonemaster; Electrochemical method; Experimental model; Hydroxyapatite; Implant surface; Osteoinduction; Porous titanium