title: Relationship between CCR2-V64I polymorphism and cancer risk: a meta-analysis.
abstract: OBJECTIVE
  The role of CCR2-V64I polymorphism in various cancers has been reported in many studies. However, results from published studies on the association between CCR2-V64I polymorphism and cancer risk are conflicting. Therefore, we performed a meta-analysis to estimate the overall cancer risk associated with the polymorphism.
  
  
  METHODS
  Electronic searches of PubMed and EMBASE were conducted for all publications on the association between this variant and cancer. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to access the strength of this association.
  
  
  RESULTS
  Sixteen studies with 2661 cancer patients and 5801 healthy controls were included. Overall, significant association was found between the CCR2-V64I polymorphism and cancer risk (OR=1.84, 95% CI=1.35-2.51, AA vs GA/GG, P=0.37). In the subgroup analysis stratified by cancer types, there was a significant association between this polymorphism and bladder cancer (OR=2.06, 95% CI=1.02-4.15, AA vs GA/GG, P=0.11), cervical cancer (OR=3.34, 95% CI=1.48-7.50, AA vs GG, P=0.56), and oral cancer (OR=2.04, 95% CI=1.46-2.84, GA vs GG, P=0.70). In the subgroup analysis stratified by ethnicities, an increased cancer risk was also found in Europeans (OR=2.31, 95% CI=1.45-3.68, AA vs GA/GG, P=0.16) and Asians (OR=1.88, 95% CI=1.12-3.16, AA vs GA/GG, P=0.92).
  
  
  CONCLUSIONS
  This meta-analysis suggested that CCR2-V64I polymorphism may contribute to an increased risk of cancer.
authors.affiliation: Department of Respiratory Diseases, Tongji Hospital, Key Lab. of Pulmonary Diseases of Health Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Yuyun
authors.initials: Y
authors.lastname: Huang
authors.forename: Huilong
authors.initials: H
authors.lastname: Chen
authors.forename: Jianmiao
authors.initials: J
authors.lastname: Wang
authors.forename: Hansvin
authors.initials: H
authors.lastname: Bunjhoo
authors.forename: Weining
authors.initials: W
authors.lastname: Xiong
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Xu
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhao
mesh_terms: D044466:Asian People / Q000235:genetics; D016001:Confidence Intervals; D016208:Databases, Factual; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009062:Mouth Neoplasms / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias; D054390:Receptors, CCR2 / Q000235:genetics*; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000208:ethnology / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C515334:CCR2 protein, human; D054390:Receptors, CCR2