title: Iso-seco-tanapartholides: Isolation, Synthesis and Biological Evaluation.
abstract: The isolation, identification and total synthesis of two plant-derived inhibitors of the NF-κB signaling pathway from the iso-seco-tanapartholide family of natural products is described. A key step in the efficient reaction sequence is a late-stage oxidative cleavage reaction that was carried out in the absence of protecting groups to give the natural products directly. A detailed comparison of the synthetic material with samples of the natural products proved informative. Biological studies on synthetic material confirmed that these compounds act late in the NF-κB signaling pathway. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009).
authors.affiliation: School of Chemistry and Biomedical Sciences Research Complex, University of St. Andrews North Haugh, St. Andrews, Fife, KY16 9ST, United Kingdom.
authors.forename: Edward F
authors.initials: EF
authors.lastname: Makiyi
authors.forename: Raquel F M
authors.initials: RF
authors.lastname: Frade
authors.forename: Tomas
authors.initials: T
authors.lastname: Lebl
authors.forename: Ellis G
authors.initials: EG
authors.lastname: Jaffray
authors.forename: Susan E
authors.initials: SE
authors.lastname: Cobb
authors.forename: Alan L
authors.initials: AL
authors.lastname: Harvey
authors.forename: Alexandra M Z
authors.initials: AM
authors.lastname: Slawin
authors.forename: Ronald T
authors.initials: RT
authors.lastname: Hay
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Westwood
keywords: Cleavage reaction; Inflammation; Natural products; Terpenoids; Total synthesis