title: Serum osteocalcin levels in relation to metabolic syndrome in Chinese postmenopausal women.
abstract: OBJECTIVE
  It has been revealed that osteocalcin is a regulator of energy metabolism. We investigated the relationship between serum osteocalcin levels and metabolic syndrome (MetS) in Chinese postmenopausal women.
  
  
  METHODS
  A total of 1,789 postmenopausal women, aged 41 to 78 years, were selected from four communities in Shanghai, China. Serum levels of osteocalcin were measured with an electrochemiluminescence immunoassay. The diagnostic definition of MetS followed the 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults.
  
  
  RESULTS
  Serum osteocalcin levels were significantly lower in participants with MetS than in non-MetS participants (median [interquartile range], 18.51 [15.52-23.46] vs. 21.09 [16.98-26.26] ng/mL, P < 0.01). The frequency of MetS and its components decreased with increasing increments of serum osteocalcin levels (all P for trend < 0.05), with the exception of the frequency of low levels of high-density lipoprotein cholesterol. Serum osteocalcin levels significantly decreased with increasing number of metabolic disorders (P for trend < 0.01). Furthermore, binary logistic regression analysis revealed that participants with higher serum osteocalcin levels had lower odds ratios (ORs) for MetS (OR, 0.123; 95% CI, 0.053-0.283), central obesity (OR, 0.134; 95% CI, 0.060-0.299), and hyperglycemia (OR, 0.142; 95% CI, 0.066-0.302).
  
  
  CONCLUSIONS
  Serum osteocalcin levels are negatively associated with MetS, particularly central obesity and hyperglycemia, in Chinese postmenopausal women.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Ma
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Pan
authors.forename: Feifei
authors.initials: F
authors.lastname: Wang
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Luo
authors.forename: Chengchen
authors.initials: C
authors.lastname: Gu
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002681:China; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood; D015675:Osteocalcin / Q000097:blood*; D017698:Postmenopause / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D015675:Osteocalcin