title: The correlation between post-operative fentanyl requirements andμ-opioid receptor gene A118G polymorphism in patients undergoing radical gastrectomy.
abstract: The aim of this study was to investigate the effect of theμ-opioid receptor gene (OPRM1) A118G polymorphism on the requirement for post-operative fentanyl analgesia in patients undergoing radical gastrectomy. One hundred and twenty-eight gastric cancer patients scheduled to undergo radical gastrectomy under general anesthesia were enrolled in the study. Post-operative, patient-controlled intravenous analgesia of fentanyl was provided for satisfactory analgesia until 48 h after surgery. OPRM1 A118G was screened by DNA sequence analysis of polymerase chain reaction (PCR)-amplified DNA. Differences in fentanyl consumption and adverse effects were compared among the different genotypes at 24 and 48 h after surgery. The ranges of fentanyl dose in the 128 patients at 24 and 48 h after surgery were 5.4-17.3μg/kg and 12.4-29.9μg/kg, respectively. Among these patients, there were 54 wild-type homozygotes (AA), 53 heterozygotes (AG) and 21 mutant homozygotes (GG). The frequency of the G allele was 0.371 in the OPRM1 polymorphism. There were no significant differences in fentanyl dose or adverse effects, including nausea, vomiting and dizziness, for the OPRM1 A118G polymorphism (P>0.05). The OPRM1 A118G polymorphism does not play a significant role in post-operative fentanyl analgesic dose or post-operative nausea, vomiting and dizziness in patients undergoing radical gastrectomy.
authors.affiliation: Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha 410013, P.R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Qin
authors.initials: Q
authors.lastname: Liao
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Sai-Ying
authors.initials: SY
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
authors.forename: Yong-Zhong
authors.initials: YZ
authors.lastname: Tang
authors.forename: Wen
authors.initials: W
authors.lastname: Ouyang
keywords: analgesia; fentanyl; mu opioid receptors; single nucleotide polymorphism