title: Comment on "Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters".
abstract: Conrad et al. (Reports, 10 August 2012, p. 742) reported that Drosophila dosage compensation might largely be due to increased recruitment of RNA polymerase II to promoters. A reassessment of the numerical operations revealed that the authors' calculations are severely confounded by an inappropriate numerical procedure. A rectified analysis strongly suggests that the authors' conclusions are not supported by their data.
authors.affiliation: Bioinformatic Unit, Adolf-Butenandt-Institute and Center for Integrated Protein Science, Ludwig-Maximilians-University, D-80336 Munich, Germany. tobias.straub@lmu.de
authors.forename: Tobias
authors.initials: T
authors.lastname: Straub
authors.forename: Peter B
authors.initials: PB
authors.lastname: Becker
mesh_terms: D000818:Animals; D004257:DNA Polymerase II / Q000378:metabolism*; D004303:Dosage Compensation, Genetic; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000378:metabolism*; D005260:Female; D050172:Genes, X-Linked; D008297:Male; D011401:Promoter Regions, Genetic; D014960:X Chromosome / Q000235:genetics*
chemical_list: D029721:Drosophila Proteins; D004257:DNA Polymerase II