title: Correlation of risk scores with coronary anatomy in non-ST-elevation acute coronary syndrome.
abstract: BACKGROUND
  The literature lacks studies regarding the correlation between risk scores and coronary anatomy in acute coronary syndrome (ACS) OBJECTIVE: Correlate risk scores with the severity of the coronary lesion in ACS with non-ST elevation.
  
  
  METHODS
  A total of 582 patients were analyzed between July 2004 and October 2006. The correlation between TIMI risk scores and GRACE (hospital and six months) scores was performed for patients with coronary lesion ≥ 50%, using Spearman's non-parametric method. Multiple regression logistics was used to determine the predictive ability of the scores to discriminate to discriminate who will have a coronary lesion ≥ 50%.
  
  
  RESULTS
  Most subjects were male (319 or 54.8%), mean age of 59.9 (± 10.6) years. A positive correlation was observed between risk scores and coronary lesion ≥ 50% (TIMI r = 0.363 [p < 0.0001]; hospital GRACE r = 0.255 [p < 0.0001]; GRACE at six months r = 0.209 [< 0.0001]). The area under the ROC curve for each score to determine to discriminate who will have a coronary lesion > 50% was: TIMI = 0.704 [CI95% 0.656-0.752; p <0.0001]; hospital GRACE = 0.623 [CI95% 0.573-0.673; p < 0.0001]; GRACE at six months= 0.562 [CI95% 0.510-0.613; p ;= 0.0255]. Comparing the areas under the ROC curve, it was found: TIMI versus hospital GRACE: p = 0.01; TIMI versus GRACE at six months:p < 0.0001; hospital GRACE versus GRACE at six months: p = 0.0461.
  
  
  CONCLUSIONS
  Risk scores correlate with the severity of coronary lesions, and the TIMI risk score showed the best predictive ability.
authors.affiliation: Instituto Dante Pazzanese de Cardiologia, São Paulo, SP, Brazil. elizabetessantos@cardiol.br
authors.forename: Elizabete Silva dos
authors.initials: ES
authors.lastname: Santos
authors.forename: Luciano de Figueiredo
authors.initials: Lde F
authors.lastname: Aguiar Filho
authors.forename: Daniela Menezes
authors.initials: DM
authors.lastname: Fonseca
authors.forename: Hugo José
authors.initials: HJ
authors.lastname: Londero
authors.forename: Rogério Martins
authors.initials: RM
authors.lastname: Xavier
authors.forename: Marcos Paulo
authors.initials: MP
authors.lastname: Pereira
authors.forename: Luiz
authors.initials: L
authors.lastname: Minuzzo
authors.forename: Roberta de
authors.initials: Rd
authors.lastname: Souza
authors.forename: Ari
authors.initials: A
authors.lastname: Timerman
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis*; D000368:Aged; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012720:Severity of Illness Index