title: Future perspectives in transcatheter aortic valve implantation.
abstract: Transcatheter aortic valve replacement (TAVR) constitutes a relatively new treatment option for the patients with severe symptomatic aortic stenosis. Evidence from registries and randomized control trials has underscored the value of this treatment in inoperable and high risk populations, while new developments in valve technology and TAVR enabling devices have reduced the risk of complications, simplified the procedure, and broadened the applications of this therapy. The initial promising clinical results and the potential of an effective less invasive treatment of aortic stenosis has not only created high expectations but also the need to address the pitfalls of TAVR technology. The evolving knowledge concerning the groups of patients who would benefit from this treatment, the limited long term follow-up data, the concerns about devices' long term durability, and the severity of complications remain important caveats which restrict the widespread clinical adoption of TAVR. The aim of this review article is to present the recent advances, highlight the limitations of TAVR technology, and discuss the future perspectives in this rapidly evolving field.
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Christos V
authors.initials: CV
authors.lastname: Bourantas
authors.forename: Nicolas M
authors.initials: NM
authors.lastname: van Mieghem
authors.forename: Vasim
authors.initials: V
authors.lastname: Farooq
authors.forename: Osama I
authors.initials: OI
authors.lastname: Soliman
authors.forename: Stephan
authors.initials: S
authors.lastname: Windecker
authors.forename: Nicolo
authors.initials: N
authors.lastname: Piazza
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D000818:Animals; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000601:surgery*; D006328:Cardiac Catheterization / Q000295:instrumentation / Q000379:methods / Q000639:trends*; D005544:Forecasting; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation / Q000379:methods / Q000639:trends*; D006801:Humans; D011474:Prosthesis Design / Q000295:instrumentation / Q000379:methods / Q000639:trends*
keywords: Aortic stenosis; Cardiovascular imaging; Transcatheter aortic valve replacement