title: Intermediate filaments: not just for structure anymore.
abstract: A recent paper has identified the tumor suppressor APC as a linker protein between intermediate filaments and microtubules. In the absence of APC, intermediate filaments collapse and the cells are no longer polarized and fail to migrate.
authors.affiliation: Department of Pathology and Cell Biology, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA. rkl2@columbia.edu
authors.forename: Ronald K H
authors.initials: RK
authors.lastname: Liem
mesh_terms: D025601:Adenomatous Polyposis Coli Protein / Q000378:metabolism*; D000818:Animals; D001253:Astrocytes / Q000166:cytology*; D002465:Cell Movement; D006801:Humans; D007382:Intermediate Filaments / Q000378:metabolism*
chemical_list: D025601:Adenomatous Polyposis Coli Protein