title: Alterations of the default mode network in functional dyspepsia patients: a resting-state fmri study.
abstract: BACKGROUND
  Increasing brain imaging studies have emphasized the role of regional brain activity abnormalities in functional dyspepsia (FD) during the resting state. The goal of this study was to investigate the default mode network (DMN) in FD patients and healthy controls (HCs).
  
  
  METHODS
  Resting-state functional magnetic resonance imaging (fMRI) scanning was carried out on 49 patients and 39 HCs. Independent component analysis (ICA) was used to isolate the DMN in each subject. Group topography of the DMN was compared to study significant alteration in FD. A correlation analysis was then performed in the FD group to investigate the effects of symptom severity and the psychological factors on the DMN.
  
  
  RESULTS
  Significant spatial differences with the DMN in FD patients, compared with HCs, were mainly found in the dorsomedial prefrontal cortex (dmPFC), ventromedial prefrontal cortex (vmPFC), orbitofrontal cortex (OFC), pregenual anterior cingulate cortex (pACC), thalamus, parahippocampal gyrus, precuneus, parietal cortex, and temporal pole. Meanwhile, Nepean Dyspepsia Index (NDI) scores were positively correlated with the pACC, and was negative correlated with the OFC. However, both the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores were not correlated with any regions of interest showing differences between the FD patients and the HCs.
  
  
  CONCLUSIONS
  These findings suggested that the DMN might indeed undergo dysfunctional changes due to the abnormal persistent activity in FD patients. To a certain extent, the changes in the DMN were related to the FD-related symptom severity.
authors.affiliation: Life Science Research Center, School of Life Science and Technology, Xidian University, Xi'an, China.
authors.forename: P
authors.initials: P
authors.lastname: Liu
authors.forename: F
authors.initials: F
authors.lastname: Zeng
authors.forename: G
authors.initials: G
authors.lastname: Zhou
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Wen
authors.forename: K M
authors.initials: KM
authors.lastname: von Deneen
authors.forename: W
authors.initials: W
authors.lastname: Qin
authors.forename: F
authors.initials: F
authors.lastname: Liang
authors.forename: J
authors.initials: J
authors.lastname: Tian
mesh_terms: D000328:Adult; D001007:Anxiety / Q000175:diagnosis / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D003863:Depression / Q000175:diagnosis / Q000503:physiopathology; D059026:Diagnostic Self Evaluation; D004415:Dyspepsia / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales