title: Intra-oral PTH administration promotes tooth extraction socket healing.
abstract: Intermittent parathyroid hormone (PTH) administration increases systemic and craniofacial bone mass. However, the effect of PTH therapy on healing of tooth extraction sites is unknown. The aims of this study were to determine the effect of PTH therapy on tooth extraction socket healing and to examine whether PTH intra-oral injection promotes healing. The mandibular first molars were extracted in rats, and subcutaneous PTH was administered intermittently for 7, 14, and 28 days. In a second study, maxillary second molars were extracted, and PTH was administered by either subcutaneous or intra-oral injection to determine the efficacy of intra-oral PTH administration. Healing was assessed by micro-computed tomography and histomorphometric analyses. PTH therapy accelerated the entire healing process and promoted both hard- and soft-tissue healing by increasing bone fill and connective tissue maturation. PTH therapy by intra-oral injection was as effective as subcutaneous injection in promoting tooth extraction socket healing. The findings suggest that PTH therapy promotes tooth extraction socket healing and that intra-oral injections can be used to administer PTH.
authors.affiliation: Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
authors.forename: S
authors.initials: S
authors.lastname: Kuroshima
authors.forename: B L
authors.initials: BL
authors.lastname: Kovacic
authors.forename: K M
authors.initials: KM
authors.lastname: Kozloff
authors.forename: L K
authors.initials: LK
authors.lastname: McCauley
authors.forename: J
authors.initials: J
authors.lastname: Yamashita
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000539:Alveolar Process / Q000187:drug effects / Q000473:pathology; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D015519:Bone Density / Q000187:drug effects; D003094:Collagen / Q000032:analysis; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D007267:Injections; D007279:Injections, Subcutaneous; D007527:Isoenzymes / Q000032:analysis; D008334:Mandible / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D008437:Maxilla / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D008963:Molar / Q000601:surgery; D009504:Neutrophils / Q000473:pathology; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D010011:Osteocytes / Q000473:pathology; D010012:Osteogenesis / Q000187:drug effects; D010281:Parathyroid Hormone / Q000008:administration & dosage*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D000071681:Tartrate-Resistant Acid Phosphatase; D013997:Time Factors; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects; D055114:X-Ray Microtomography
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D010281:Parathyroid Hormone; D003094:Collagen; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase
keywords: alveolar bone loss; bone remodeling; connective tissue; inflammation; osteogenesis; wounds and injuries