title: Association between p53 gene variants and oral cancer susceptibility in population from Gujarat, West India.
abstract: BACKGROUND
  p53 gene variants i.e. 16 bp duplication in intron 3, Arg72Pro in exon 4 and G>A in intron 6 have been reported to modulate susceptibility to various malignancies. Therefore, the present study evaluated the role of these p53 polymorphisms in oral cancer susceptibility in a population from Gujarat, West India.
  
  
  METHODS
  Genotype frequencies at the three p53 loci in 110 controls and 79 oral cancer cases were determined by the PCR-RFLP method.
  
  
  RESULTS
  Heterozygous individuals at exon 4 showed protection from developing oral cancer. Homozygous wild and heterozygous individuals at intron 3 and those heterozygous at exon 4 in combination appeared to be at lowered risk. Furthermore, carriers of the 16 bp duplication allele at intron 3, proline allele at exon 4 and G allele at intron 6 were protected from oral cancer development.
  
  
  CONCLUSIONS
  p53 polymorphisms, especially Arg72Pro in exon 4 could significantly modify the risk of oral cancer development in Gujarat, West Indian population.
authors.affiliation: Biochemistry Research Division, The Gujarat Cancer and Research Institute, Ahmedabad, India.
authors.forename: Kinjal R
authors.initials: KR
authors.lastname: Patel
authors.forename: Bhairavi N
authors.initials: BN
authors.lastname: Vajaria
authors.forename: Rasheedunnisa
authors.initials: R
authors.lastname: Begum
authors.forename: Franky D
authors.initials: FD
authors.lastname: Shah
authors.forename: Jayendra B
authors.initials: JB
authors.lastname: Patel
authors.forename: Shilin N
authors.initials: SN
authors.lastname: Shukla
authors.forename: Prabhudas S
authors.initials: PS
authors.lastname: Patel
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012306:Risk; D011795:Surveys and Questionnaires; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D055815:Young Adult
chemical_list: D016159:Tumor Suppressor Protein p53