title: Influence of acid-etching after grit-blasted on osseointegration of titanium dental implants: in vitro and in vivo studies.
abstract: Rough implant surfaces have shown improved osseointegration rates. In a majority of dental implants, the microrough surfaces are obtained by grit blasting and/or acid-etching. The aim of this contribution was to evaluate the effects of acid-etching, after the grit-blasted treatment in titanium dental implants, on surface wettability, surface energy, osteoblast responses and its osseointegration behavior. Four surfaces were studied: as-machined, acid-etched, micro-rough by grit-blasting and the combination grit-blasted surface with acid-etched. The surfaces with increasing roughness show more osteoblastic adhered cells. This effect was most pronounced on samples blasted and blasted with acid-etching. The roughness obtained by grit-blasting is the main factor in comparison with the acid etching treatment in the biological response. These results were confirmed in vivo tests and histological analysis. The results demonstrated that the combination of the grit-blasted and acid-etched accelerated lightly bone regeneration at the different periods of implantation in comparison with the grit-blasted implants.
authors.affiliation: Universidad de Sevilla, Sevilla, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Herrero-Climent
authors.forename: P
authors.initials: P
authors.lastname: Lázaro
authors.forename: J
authors.initials: J
authors.lastname: Vicente Rios
authors.forename: S
authors.initials: S
authors.lastname: Lluch
authors.forename: M
authors.initials: M
authors.lastname: Marqués
authors.forename: J
authors.initials: J
authors.lastname: Guillem-Martí
authors.forename: F J
authors.initials: FJ
authors.lastname: Gil
mesh_terms: D000134:Acid Etching, Dental / Q000009:adverse effects / Q000379:methods; D000818:Animals; D002478:Cells, Cultured; D003758:Dental Implantation, Endosseous / Q000295:instrumentation*; D015921:Dental Implants / Q000009:adverse effects; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D008422:Materials Testing; D016348:Osseointegration / Q000502:physiology*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D015921:Dental Implants; D014025:Titanium