title: Inclusion-body myositis associated with Alzheimer's disease.
abstract: Sporadic inclusion-body myositis (s-IBM) is a myopathy that is characterized by progressive weakness and muscle pathology demonstrating inflammation and rimmed vacuoles. In addition, similar to the pathology observed in the brains of patients with Alzheimer's disease, the deposition of beta-amyloid and phosphorylated tau proteins in muscle fibers has been reported. These shared pathologic features have prompted hypotheses suggesting a shared etiology of these two conditions. We report a case of a 73-year-old woman initially diagnosed with s-IBM who later developed Alzheimer's disease.
authors.affiliation: New Jersey Neuroscience Institute at JFK Medical Center, 65 James Street, Edison, NJ, USA.
authors.forename: Danijela
authors.initials: D
authors.lastname: Levacic
authors.forename: Leema Reddy
authors.initials: LR
authors.lastname: Peddareddygari
authors.forename: David
authors.initials: D
authors.lastname: Nochlin
authors.forename: Leroy R
authors.initials: LR
authors.lastname: Sharer
authors.forename: Raji P
authors.initials: RP
authors.lastname: Grewal