title: Catheter-based radiofrequency renal sympathetic denervation for resistant hypertension.
abstract: OBJECTIVE
  To evaluate the feasibility, efficacy, and safety of catheter-based radiofrequency renal sympathetic denervation for treatment of resistant hypertension.
  
  
  METHODS
  Twenty-four patients with essential hypertension unresponsive to at least three antihypertensive agents underwent renal denervation (RDN). Three patients had variant renal anatomy. Comorbidities included diabetes (n = 11), renal failure (n = 4), and obstructive sleep apnea (n = 2). The effect on 24-hour ambulatory blood pressure (BP) was assessed at 6 months. Patients with a decrease in systolic BP of at least 10mm Hg were considered responders.
  
  
  RESULTS
  RDN was bilateral in 19 patients and single-sided in five. The 19 patients with bilateral RDN showed mean reductions in 24-hour ambulatory BP of 20.7/8.7mm Hg±18.1/9.9 (systolic/diastolic; P = .0001/P = .0012). Sixteen bilaterally treated patients (84.2%) showed a systolic BP reduction of at least 10mm Hg and were considered responders, whereas only one of the five patients with single-sided RDN showed a response. Two responders with sleep apnea showed improvement in polysomnography indices, and one with left concentric ventricular hypertrophy showed complete cardiac remodeling 11 months after the RDN procedure. Renal function remained unchanged in all patients, including those with renal failure. Optical coherence tomography of the renal arteries in one patient showed sporadic endothelial scarring. Renal angiograms at 9 months (one patient) and 12 months (two patients) had normal findings.
  
  
  CONCLUSIONS
  Catheter-based RDN was carried out safely, even in patients with comorbidities, abnormal renal arteries, or anatomic variants. The response rate for bilateral RDN (84.2%) was comparable to previous reports.
authors.affiliation: Department of Interventional Radiology, EMO GVM Centro Cuore Columbus, Milan, Italy. bruno.damascelli@fastwebnet.it
authors.forename: Bruno
authors.initials: B
authors.lastname: Damascelli
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Patelli
authors.forename: Vladimira
authors.initials: V
authors.lastname: Tichá
authors.forename: Federica
authors.initials: F
authors.lastname: Della Rocca
authors.forename: Salvatore
authors.initials: S
authors.lastname: Lattuada
authors.forename: Chiara
authors.initials: C
authors.lastname: Sala
authors.forename: Alberto
authors.initials: A
authors.lastname: Albertoni
authors.forename: Andrea
authors.initials: A
authors.lastname: D'Alessio
authors.forename: Alfonso
authors.initials: A
authors.lastname: Funaro
authors.forename: Lorenza
authors.initials: L
authors.lastname: Scotti
mesh_terms: D000368:Aged; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000175:diagnosis* / Q000601:surgery*; D007668:Kidney / Q000294:innervation* / Q000601:surgery*; D008297:Male; D013562:Sympathectomy / Q000379:methods*; D016896:Treatment Outcome