title: Chronic angle-closure glaucoma related to paroxetine treatment.
abstract: OBJECTIVE
  To present a unique case of a 33-year-old woman using paroxetine who presented with acute unilateral visual loss due to chronic angle-closure glaucoma.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 33-year-old women who had been under paroxetine treatment for the past four months presented at the emergency room due to a sudden loss of visual acuity (VA) in the left eye (LE). Narrow anterior chamber was detected. Intraocular pressure (IOP) was 29 mmHg right eye (RE) and 42 mm Hg LE. A fundus exam revealed a cup-to-disc ratio of 0.9-1 for the LE and of 0.1-0.2 for the RE. Paroxetine treatment was suspended, and after 48 h IOP was 10 mm Hg in both eyes (BE). ND-YAG laser iridotomy was performed in BE. In the subsequent visit, IOP was 25 mm Hg in the RE and 41 mm Hg in the LE; on her own initiative the patient had resumed paroxetine treatment. After requesting the patient again to stop taking the anti-depressant, IOP was 10 mm Hg in BE in the next exam 48 h later.
  
  
  CONCLUSIONS
  As far as we are aware, there are no other reports of chronic angle-closure glaucoma related to the use of paroxetine. We thus consider that, before initiating treatment with this drug, patients should be informed of its potential ocular risks and they should be subjected to an ophthalmologic examination before its use is authorized.
authors.affiliation: Department of Ophthalmology, Hospital el Bierzo, Ponferrada, León, Spain. federicosaenzfrancessb@gmail.com
authors.forename: M A
authors.initials: MA
authors.lastname: Sierra-Rodriguez
authors.forename: F
authors.initials: F
authors.lastname: Saenz-Frances
authors.forename: E
authors.initials: E
authors.lastname: Santos-Bueso
authors.forename: J
authors.initials: J
authors.lastname: Garcia-Feijoo
authors.forename: J C
authors.initials: JC
authors.lastname: Gonzelez-Romero
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D002908:Chronic Disease; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure; D032801:Iridectomy; D053844:Lasers, Solid-State / Q000627:therapeutic use; D017374:Paroxetine / Q000009:adverse effects*; D015354:Vision, Low / Q000139:chemically induced; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine