title: Multimodal imaging-monitored progression of stroke-like episodes in a case of MELAS syndrome.
abstract: We report imaging findings during, between, and after 2 stroke-like episodes in a 45-year-old woman with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome with an A32243G mitochondrial mutation 6 years before. In November 2010, for a first episode, she showed mixed aphasia with logorrhea, disinhibition, agitation, euphoria, and a large left temporoparietal lesion. Symptomatology progressively regressed under L-arginine treatment. She was readmitted in June 2011 for a second episode with great anxiety, disorientation, impaired face recognition, worsening mixed aphasia, and a new right temporal lesion. After additional L-carnitine treatment, she remained without relapse for 14 months.
authors.affiliation: From the *Service de Biophysique et Médecine Nucléaire, †Unité de Neuro-vasculaire, and ‡Service de Radiologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg; and §Université de Strasbourg/CNRS, UMR 7237, Strasbourg, France.
authors.forename: Izzie Jacques
authors.initials: IJ
authors.lastname: Namer
authors.forename: Valérie
authors.initials: V
authors.lastname: Wolff
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Dietemann
authors.forename: Christian
authors.initials: C
authors.lastname: Marescaux
mesh_terms: D018450:Disease Progression; D005260:Female; D006801:Humans; D017241:MELAS Syndrome / Q000150:complications* / Q000473:pathology*; D008875:Middle Aged; D064847:Multimodal Imaging; D020521:Stroke / Q000150:complications* / Q000473:pathology*