title: Relation of resistın wıth obesity and some cardiovascular risk factors in hypertensive women.
abstract: BACKGROUND
  Hypertension and obesity are risk factors of cardiovascular disease. The association between C-reactive protein, homocysteine, microalbuminuria and cardiovascular risk have been debated for decades. Resistin is a newly discovered adipocyte derived cytokine. In the current study we planned to investigate the relation of resistin to these probable cardiovascular risk factors and obesity in hypertensive patients.
  
  
  METHODS
  The study population consisted of 42 non-obese and 42 obese hypertensive females. After making comparisons between C-reactive protein, homocysteine, microalbuminuria and resistin in the two groups, we also sought correlations between all parameters in non-obese and obese groups.
  
  
  RESULTS
  In our obese hypertensive group, resistin levels were higher than in the non-obese hypertensive group (p < 0.001), but we did not find any difference in other parameters. We found a positive correlation between resistin and C-reactive protein in both non-obese and obese hypertensive groups (in non-obese hypertensives p < 0.05, and in obese hypertensives p < 0.001).
  
  
  CONCLUSIONS
  We showed that in female obese hypertensive patients resistin levels were higher than in the non-obese patients. We also think that resistin may be associated with C-reactive protein levels but not with homocysteine or microalbuminuria in both non-obese and obese hypertensive patients.
authors.affiliation: Departement of Internal Medicine, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Gül
authors.initials: G
authors.lastname: Gürsoy
authors.forename: Sena
authors.initials: S
authors.lastname: Ulu
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Acar
authors.forename: Berrin
authors.initials: B
authors.lastname: Demirbaş
authors.forename: Süleyman
authors.initials: S
authors.lastname: Alkan
authors.forename: Birsen
authors.initials: B
authors.lastname: Erol
authors.forename: Işıl
authors.initials: I
authors.lastname: Ozaşık
keywords: C-reactive protein; Homocysteine; Hypertension; Microalbuminuria; Obesity; Resistin