title: Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum.
abstract: BACKGROUND
  Nothing is reported on Amphilophium paniculatum (L.) Kunth. This study aimed at investigation of chemical constituents of the leaves of Amphilophium paniculatum, grown in Egypt, in addition to pharmacological evaluation.
  
  
  METHODS
  Isolation of a new compound, along with 5 known flavonoids. Pharmacological activities were carried out on different extracts of A. paniculatum leaves.
  
  
  RESULTS
  Identification of a new flavone glycoside, acacetin 8-C-β-D- glucopyranosy l-(1→2)-α-L-rhamnopyranoside (1) in addition to 5 known flavonoids. The 70% ethanol crud extract and its successive chloroform, ethyl acetate, and 100% ethanol extracts showed significant anti-inflammatoryactivity,analgesic effect, antipyretic activity, antioxidant activity, and anti-hyperglycemic activity. Determination of the median lethal dose (LD50) revealed that the different extracts were safe.
authors.affiliation: Department of Chemistry of Natural Compounds, National Research Centre, Dokki, Egypt.
authors.forename: Mahmoud I
authors.initials: MI
authors.lastname: Nassar
authors.forename: El-Sayed A
authors.initials: el-SA
authors.lastname: Aboutabl
authors.forename: Dina M
authors.initials: DM
authors.lastname: Eskander
authors.forename: Mary H
authors.initials: MH
authors.lastname: Grace
authors.forename: Ezzel-Din A
authors.initials: ED
authors.lastname: El-Khrisy
authors.forename: Amany A
authors.initials: AA
authors.lastname: Sleem
keywords: Amphilophium paniculatum; bignoniaceae; flavonoids; pharmacology