title: [Study of testicular cancer gene expression in samples of oral leukoplakia and squamous cell carcinoma of the mouth].
abstract: Cancer-testis (CT) antigens are normally expressed mostly in human germ cells, there is also an aberrant expression in some tumor cells. This expression profile makes them potential tumor growth biomarkers and a promising target for tumor immunotherapy. Specificity of CT genes expression in oral malignant and potentially malignant diseases, e.g. oral leukoplakia, is not yet studied. Data on CT genes expression profile in leukoplakia would allow developing new diagnostic methods with potential value for immunotherapy and prophylaxis of leukoplakia malignization. In our study we compared CT genes expression in normal oral mucosa, oral leukoplakia and oral squamous cell carcinoma. We are the first to describe CT genes expression in oral leukoplakia without dysplasia. This findings make impossible differential diagnosis of oral leukoplakia and squamous cell carcinoma on the basis of CT genes expression. The prognostic value of CT genes expression is still unclear, therefore the longitudinal studies are necessary.
authors.forename: L O
authors.initials: LO
authors.lastname: Skorodumova
authors.forename: A A
authors.initials: AA
authors.lastname: Muraev
authors.forename: E S
authors.initials: ES
authors.lastname: Zakharova
authors.forename: M V
authors.initials: MV
authors.lastname: Shepelev
authors.forename: I V
authors.initials: IV
authors.lastname: Korobko
authors.forename: I A
authors.initials: IA
authors.lastname: Zaderenko
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Ivanov
authors.forename: N V
authors.initials: NV
authors.lastname: Gnuchev
authors.forename: G P
authors.initials: GP
authors.lastname: Georgiev
authors.forename: S S
authors.initials: SS
authors.lastname: Larin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D002471:Cell Transformation, Neoplastic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000276:immunology*; D007972:Leukoplakia, Oral / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000276:immunology* / Q000473:pathology; D009062:Mouth Neoplasms / Q000276:immunology*; D011230:Precancerous Conditions / Q000276:immunology*; D011237:Predictive Value of Tests; D011379:Prognosis; D013736:Testicular Neoplasms / Q000276:immunology*; D013737:Testis / Q000276:immunology*; D014062:Tongue Neoplasms / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm