title: Evidence for G-quadruplex DNA in human cells.
abstract: Seen in human cells: A fluorochrome-labeled antibody probe selectively and efficiently binds all types of DNA G-quadruplex with similar binding affinities, but hardly binds single- or double-stranded DNA, or RNA hairpins. Thus, this antibody strictly discriminates between G-quadruplex structures and other conformations of DNA and provides evidence for G-quadruplex DNA in human cells.
authors.affiliation: Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. xuyan@fc.miyazaki-u.ac.jp
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.forename: Makoto
authors.initials: M
authors.lastname: Komiyama
mesh_terms: D000906:Antibodies / Q000032:analysis; D002875:Chromosomes / Q000737:chemistry; D004247:DNA / Q000032:analysis*; D005455:Fluorescent Antibody Technique / Q000379:methods*; D054856:G-Quadruplexes; D006801:Humans
chemical_list: D000906:Antibodies; D004247:DNA