title: Oxidant/antioxidant status in cases of snake bite.
abstract: BACKGROUND
  Snake bites are an important cause of mortality and morbidity worldwide, especially in rural areas.
  
  
  OBJECTIVE
  The aim of this study was to investigate serum paraoxonase (PON), arylesterase (ARLY), ceruloplasmin (Cp), and myeloperoxidase (MPO) activity and lipid hydroperoxide (LOOH) and total sulfhydryl group (-SH) levels in patients with snake venom poisoning.
  
  
  METHODS
  The study included 49 patients with snake bite envenomation (Group 1) and 39 healthy volunteers as the control group (Group 2). Plasma PON, ARLY, Cp, and MPO activity and LOOH and -SH levels were measured. Laboratory measurements of 20 patients with snake bite envenomation (Group 3) were performed again after treatment.
  
  
  RESULTS
  PON and ARLY activity and -SH levels were significantly decreased in Group 1 compared with those in Group 2. Cp and MPO activity and LOOH levels were significantly elevated in Group 1 compared with those in Group 2. PON and ARLY activity were significantly elevated in Group 3 compared with those in Group 1. Cp and MPO activity and LOOH levels were significantly decreased in Group 3 compared with those in Group 1.
  
  
  CONCLUSIONS
  Patients with snake bite envenomation had increased oxidants (MPO and LOOH) and decreased antioxidants (PON, ARLY, and -SH). Results obtained in this study demonstrate that snake bites are associated with a shift to oxidative status. Therapy with antioxidants can lead to an increase in the antioxidant defense system, and thus improvements in clinical symptoms.
authors.affiliation: Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Suat
authors.initials: S
authors.lastname: Zengin
authors.forename: Behcet
authors.initials: B
authors.lastname: Al
authors.forename: Pinar
authors.initials: P
authors.lastname: Yarbil
authors.forename: Seyithan
authors.initials: S
authors.lastname: Taysi
authors.forename: Hasan
authors.initials: H
authors.lastname: Bilinc
authors.forename: Cuma
authors.initials: C
authors.lastname: Yildirim
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000328:Adult; D000975:Antioxidants; D000997:Antivenins / Q000627:therapeutic use; D043303:Aryldialkylphosphatase / Q000097:blood; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000378:metabolism; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood*; D009195:Peroxidase / Q000097:blood; D012909:Snake Bites / Q000097:blood* / Q000188:drug therapy / Q000628:therapy; D013438:Sulfhydryl Compounds / Q000097:blood; D055815:Young Adult
chemical_list: D000975:Antioxidants; D000997:Antivenins; D008054:Lipid Peroxides; D016877:Oxidants; D013438:Sulfhydryl Compounds; D009195:Peroxidase; D002570:Ceruloplasmin; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase