title: Nanovaccines and their mode of action.
abstract: Nanosized particles including nanovaccines are a novel approach to the development of vaccines to combat diseases. Nanovaccines have the promise to utilize the immune system to cure infections and to prevent infections and diseases from spreading. Rational vaccine development requires an understanding of vaccine mediated stimulation of the immune system. We review here immunostimulatory properties of nanovaccines including their immunogenicity, adjuvant properties, inflammatory responses and the mechanisms of uptake and stimulation of immune cells. Examples of various nanoparticles currently being developed as vaccines are also provided.
authors.affiliation: School of Chemistry and Molecular Biosciences (SCMB), The University of Queensland, St. Lucia 4072, Queensland, Australia. m.zaman@uq.edu.au
authors.forename: Mehfuz
authors.initials: M
authors.lastname: Zaman
authors.forename: Michael F
authors.initials: MF
authors.lastname: Good
authors.forename: Istvan
authors.initials: I
authors.lastname: Toth
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry; D000941:Antigens / Q000276:immunology*; D001428:Bacterial Vaccines / Q000138:chemical synthesis / Q000276:immunology*; D050091:Dendrimers / Q000737:chemistry; D037741:Fullerenes / Q000737:chemistry / Q000276:immunology; D006801:Humans; D007107:Immune System; D008081:Liposomes / Q000737:chemistry / Q000276:immunology; D053768:Metal Nanoparticles / Q000737:chemistry; D043942:Nanotubes / Q000737:chemistry; D014765:Viral Vaccines / Q000138:chemical synthesis / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D000941:Antigens; D001428:Bacterial Vaccines; D050091:Dendrimers; D037741:Fullerenes; D008081:Liposomes; D014765:Viral Vaccines