title: Contrast-enhanced intraoperative optical coherence tomography.
abstract: Optical coherence tomography (OCT) has revolutionised clinical ophthalmology. The translation of OCT into the operating room is a natural next step given its high-resolution anatomic information. Contrast agents and enhancement have significantly improved the diagnostic capabilities of numerous imaging modalities (such as CT and MRI). The use of OCT contrast agents in ophthalmology has been generally lacking. In this report, we describe the novel application of triamcinolone as an OCT contrast agent for intraoperative OCT to improve visibility of tissue interfaces and planes (eg, posterior hyaloid insertion points). The application of this technology may have wide-ranging implications for enhanced image-guided surgery, intraoperative OCT and dynamic or functional applications of OCT technology.
authors.affiliation: Vitreoretinal Service, Cole Eye Institute, Ophthalmic Imaging Center, Cleveland Clinic Foundation, , Cleveland, Ohio, USA.
authors.forename: Justis P
authors.initials: JP
authors.lastname: Ehlers
authors.forename: Stephen A
authors.initials: SA
authors.lastname: McNutt
authors.forename: Peter K
authors.initials: PK
authors.lastname: Kaiser
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Srivastava
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D021621:Imaging, Three-Dimensional; D007432:Intraoperative Period; D058449:Intravitreal Injections; D015203:Reproducibility of Results; D012164:Retinal Diseases / Q000473:pathology / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014221:Triamcinolone / Q000008:administration & dosage; D014821:Vitrectomy
chemical_list: D003287:Contrast Media; D005938:Glucocorticoids; D014221:Triamcinolone
keywords: Imaging; Retina; Treatment Surgery