title: Changes in blood parameters in rhesus monkeys (Macaca mulatta) during the first trimester of gestation.
abstract: BACKGROUND
  Regarding the good practice in the laboratory work, it is essential to have a broad spectrum of biochemical and hematological references in pregnant females to determine the health status of the colony.
  
  
  OBJECTIVE
  To establish reference values to reveal changes in hematology and blood chemistry in pregnant rhesus monkeys (Macaca mulatta) in their first trimester of pregnancy.
  
  
  METHODS
  Twenty-eight females in reproductive stage were used, divided into two groups: 14 pregnant macaques in their first trimester and 14 non-pregnant used as the control group. Blood samples were collected for the hematological test and blood chemistry.
  
  
  RESULTS
  The results showed significant difference in the blood chemistry for the following parameters: glucose, total bilirubin, and total protein. The hematological evaluation revealed significant difference in leukocytes and neutrophils.
  
  
  CONCLUSIONS
  These findings offer a reference range and provide a basis for improvement in techniques and refinement of clinical processes in these specimens.
authors.affiliation: Centro de Investigación, Proyecto CAMINA, A.C., Ciudad de México, México D.F, México. ibanez.alejandra@hotmail.com
authors.forename: Alejandra
authors.initials: A
authors.lastname: Ibáñez-Contreras
authors.forename: Braulio
authors.initials: B
authors.lastname: Hernández-Godínez
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Reyes-Pantoja
authors.forename: Andrea
authors.initials: A
authors.lastname: Jiménez-García
authors.forename: Salvador A
authors.initials: SA
authors.lastname: Solís-Chavéz
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Suarez-Gutiérrez
authors.forename: Alfonso
authors.initials: A
authors.lastname: Gálvan-Montaño
mesh_terms: D000818:Animals; D001663:Bilirubin / Q000097:blood*; D001772:Blood Cell Count / Q000662:veterinary; D001774:Blood Chemical Analysis / Q000662:veterinary; D001786:Blood Glucose / Q000032:analysis*; D001798:Blood Proteins / Q000032:analysis*; D005260:Female; D005865:Gestational Age; D007958:Leukocyte Count / Q000662:veterinary*; D008253:Macaca mulatta / Q000097:blood*; D009504:Neutrophils; D011247:Pregnancy; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D001663:Bilirubin
keywords: Macaca mulatta; blood chemistry; hematological test; laboratory animals; pregnancy; refinement