title: Decreased levels of circulating and tissue miR-107 in human esophageal cancer.
abstract: BACKGROUND
  Aberrant expression of miRNAs has emerged as an important hallmark of cancer.
  
  
  OBJECTIVE
  We evaluated the clinical significance of circulating and tissue miR-107 expression in esophageal squamous cell carcinoma (ESCC) patients.
  
  
  METHODS
  Quantitative real-time PCR was used to analyze the expression of miR-107 and its bioinformatically identified targets, PIM-1 and CDC42.
  
  
  RESULTS
  Significant downregulation of miR-107 was observed in neoplastic and preneoplastic esophageal tissues (p = 0.004). Relative levels of circulating miR-107 significantly distinguished ESCC patients from normal subjects (p = 0.007). Significant inverse correlation was observed between miR-107 and PIM1 expression (r = -0.398; p = 0.015) suggesting PIM1 to be the downstream target of miR-107.
  
  
  CONCLUSIONS
  Our results, for the first time, document that the miR-107 levels may discriminate ESCC patients from healthy individuals emphasizing its diagnostic potential.
authors.affiliation: University School of Biotechnology, Guru Gobind Singh Indraprastha University, Dwarka, New Delhi 110078, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Sharma
authors.forename: Anoop
authors.initials: A
authors.lastname: Saraya
authors.forename: Prerna
authors.initials: P
authors.lastname: Gupta
authors.forename: Rinu
authors.initials: R
authors.lastname: Sharma
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000378:metabolism*; D015536:Down-Regulation; D004938:Esophageal Neoplasms / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; C549045:MIRN107 microRNA, human; D035683:MicroRNAs