title: RNAi: antiviral therapy against dengue virus.
abstract: Dengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is an important and effective gene silencing process which degrades targeted RNA by a sequence specific process. Several studies have been conducted during the last decade to evaluate the efficiency of siRNA in inhibiting dengue virus replication. This review summarizes siRNAs as a therapeutic approach against dengue virus serotypes and concludes that siRNAs against virus and host genes can be next generation treatment of dengue virus infection.
authors.affiliation: Department of Bioinformatics and Biotechnology, Government College University (GCU), Faisalabad, Pakistan.
authors.forename: Sobia
authors.initials: S
authors.lastname: Idrees
authors.forename: Usman A
authors.initials: UA
authors.lastname: Ashfaq
mesh_terms: D000818:Animals; D003715:Dengue / Q000628:therapy*; D003716:Dengue Virus / Q000235:genetics*; D006801:Humans; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics / Q000627:therapeutic use*
chemical_list: D034741:RNA, Small Interfering
keywords: Dengue haemorrhagic fever; Dengue virus; RNA interference; Small interference RNA