title: Fabrication and characterization of novel diopside/silk fibroin nanocomposite scaffolds for potential application in maxillofacial bone regeneration.
abstract: Novel freeze-dried porous composite scaffolds were prepared from natural polymer of silk fibroin (SF) as a matrix and from diopside nanoceramic as a bioactive reinforcing agent through a freeze-drying method. Considering the superiority of both diopside and SF in terms of mechanical and biochemical properties (in comparison to similar ceramics and polymers, especially in maxillofacial specific applications), we investigated the effect of diopside nanoparticle contents. Microstructure studies illustrated that the bioactive diopside nanoparticles were distributed throughout the fibroin matrix. Enough porosity, desired surface properties, high mechanical strength and excellent in vitro biocompatibility were achieved during the fabrication of the nanocomposite scaffolds without any extra modifications.
authors.affiliation: Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran. le_ghorbanian@yahoo.com
authors.forename: Leila
authors.initials: L
authors.lastname: Ghorbanian
authors.forename: Rahmatollah
authors.initials: R
authors.lastname: Emadi
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Razavi
authors.forename: Heungsoo
authors.initials: H
authors.lastname: Shin
authors.forename: Abbas
authors.initials: A
authors.lastname: Teimouri
mesh_terms: D016475:3T3 Cells; D000818:Animals; D012831:Bombyx; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry* / Q000633:toxicity; D005349:Fibroins / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D008437:Maxilla / Q000502:physiology*; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D016062:Porosity; D044968:Regenerative Medicine; D012824:Silicic Acid / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D012824:Silicic Acid; C074224:diopside; D005349:Fibroins