title: Cell-free DNA: characteristics, detection and its applications in myocardial infarction.
abstract: Much attention has been focused on cell-free DNA (cf-DNA) and its levels in the plasma, serum and body fluids of pregnant women and patients with cancer or autoimmune disease, and those with severe trauma; however, knowledge of its biology and relationship with myocardial infarction (MI) is still at an early stage. This paper introduces general aspects of the nomenclature, structure, function, release mechanisms and methodology of cf-DNA and summarizes the current literature on concentration variation and regulatory mechanisms in MI.
authors.affiliation: Center of Laboratory Medicine, Affiliated Hospital of Nantong University, Jiangsu Province, China.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Jing
authors.forename: Ming
authors.initials: M
authors.lastname: Cui
authors.forename: Huimin
authors.initials: H
authors.lastname: Wang
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Ju
mesh_terms: D000818:Animals; D017209:Apoptosis; D015415:Biomarkers; D004247:DNA / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D053938:DNA Fragmentation; D018450:Disease Progression; D045604:Extracellular Fluid / Q000378:metabolism; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008970:Molecular Weight; D009203:Myocardial Infarction / Q000097:blood / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009336:Necrosis; D009690:Nucleic Acid Conformation; D009626:Terminology as Topic
chemical_list: D015415:Biomarkers; D004247:DNA