title: Reasons of carcinogenesis indicate a big-bang inside: a hypothesis for the aberration of DNA methylation.
abstract: Cancer involves various sets of altered gene functions which embrace all the three basic mechanisms of regulation of gene expression. However, no common mechanism is inferred till date for this versatile disease and thus no full proof remedy can be offered. Here we show that the basic mechanisms are interlinked and indicate towards one of those mechanisms as being the superior one; the methylation of cytosines in specific DNA sequences, for the initiation and maintenance of carcinogenesis. The analyses of the previous reports and the nucleotide sequences of the DNA methyltransferases strongly support the assumption that the mutation(s) in the DNA-binding site(s) of DNA-methyltransferases acts as a master regulator; though it continues the cycle from mutation to repair to methylation. We anticipate that our hypothesis will start a line of study for the proposal of a treatment regime for cancers by introducing wild type methyltransferases in the diseased cells and/or germ cells, and/or by targeting ligands to the altered binding domain(s) where a mutation in the concerned enzyme(s) is seen.
authors.affiliation: SDOT Office, Haldia Township Telephone Exchange Campus, Bharat Sanchar Nigam Limited, P.O. Haldia Township, Purba Medinipur, West Bengal 721607, India. avraroy@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Roy
authors.forename: N
authors.initials: N
authors.lastname: Roy Chattopadhyay
mesh_terms: D063646:Carcinogenesis / Q000235:genetics; D018899:CpG Islands; D019175:DNA Methylation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D009154:Mutation
chemical_list: D035683:MicroRNAs