title: Atypical laterality of resting gamma oscillations in autism spectrum disorders.
abstract: Abnormal brain oscillatory activity has been found in autism spectrum disorders (ASD) and proposed as a potential biomarker. While several studies have investigated gamma oscillations in ASD, none have examined resting gamma power across multiple brain regions. This study investigated resting gamma power using EEG in 15 boys with ASD and 18 age and intelligence quotient matched typically developing controls. We found a decrease in resting gamma power at right lateral electrodes in ASD. We further explored associations between gamma and ASD severity as measured by the Social Responsiveness Scale (SRS) and found a negative correlation between SRS and gamma power. We believe that our findings give further support of gamma oscillations as a potential biomarker for ASD.
authors.affiliation: Center for Autism Research, Children's Hospital of Philadelphia, 3535 Market St Suite 860, Philadelphia, PA, 19104, USA.
authors.forename: Christina R
authors.initials: CR
authors.lastname: Maxwell
authors.forename: Michele E
authors.initials: ME
authors.lastname: Villalobos
authors.forename: Robert T
authors.initials: RT
authors.lastname: Schultz
authors.forename: Beate
authors.initials: B
authors.lastname: Herpertz-Dahlmann
authors.forename: Kerstin
authors.initials: K
authors.lastname: Konrad
authors.forename: Gregor
authors.initials: G
authors.lastname: Kohls
mesh_terms: D000293:Adolescent; D001921:Brain / Q000502:physiology*; D016022:Case-Control Studies; D002659:Child Development Disorders, Pervasive / Q000503:physiopathology*; D004569:Electroencephalography; D007839:Functional Laterality / Q000502:physiology*; D065818:Gamma Rhythm / Q000502:physiology*; D006801:Humans; D008297:Male; D012146:Rest