title: Immune surveillance mechanisms of the skin against the stealth infection strategy of Pseudomonas aeruginosa-review.
abstract: The present review aims to provide insight into the complex interactions between the host and Pseudomonas aeruginosa-an opportunistic microbial agent causing skin infections. Heat, humidity and skin pH are among the factors beneficial for the development of this Gram-negative agent. To cause infection, Pseudomonas aeruginosa should first overcome the primary mechanisms of defense including the cell elements and humoral factors of the skin, as well as non-specific responses-phagocytosis, inflammation, acute phase response. All they are analysed with emphasis on the fact that their detailed understanding would help revealing their potential and allow for their efficient control. The microorganism, being more alterable and more flexible than the host, uses stealth strategies and modes of life. The review goes over the arsenal of virulence factors, used by Pseudomonas aeruginosa to attack the host defense mechanisms. The bacterial pathogenic strategies for invasion, resulting in collapse of skin defense are analysed. Several novel therapeutic approached to Pseudomonas aeruginosa skin infections are briefly reviewed.
authors.affiliation: Department of General and Clinical Pathology, Functional Pathology and Immunology Unit, Faculty of Veterinary Medicine, Trakia University, 6014 Stara Zagora, Bulgaria. andonova_m@yahoo.com
authors.forename: Maria
authors.initials: M
authors.lastname: Andonova
authors.forename: Valentina
authors.initials: V
authors.lastname: Urumova
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D016328:NF-kappa B / Q000276:immunology; D053472:Nod Signaling Adaptor Proteins / Q000276:immunology; D011552:Pseudomonas Infections / Q000276:immunology* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000276:immunology / Q000472:pathogenicity*; D012867:Skin / Q000166:cytology / Q000276:immunology / Q000382:microbiology; D051193:Toll-Like Receptors / Q000276:immunology; D037521:Virulence Factors
chemical_list: D023181:Antimicrobial Cationic Peptides; D016328:NF-kappa B; D053472:Nod Signaling Adaptor Proteins; D051193:Toll-Like Receptors; D037521:Virulence Factors
keywords: Animals; Biofilm; Innate immunity; Pseudomonas aeruginosa; Skin; Therapy; Virulence factors