title: Investigation of water-soluble inclusion complex of hypericin with β-cyclodextrin polymer.
abstract: A water-soluble inclusion complex of hypericin (HY) with β-cyclodextrin polymer (CDP) was achieved by supramolecular interactions between HY and CDP. The inclusion complex (HY-CDP) was characterized by (1)H NMR, FTIR, and UV-vis spectroscopies. Compared with HY, the water-solubility of HY-CDP was greatly enhanced because of the water-soluble CDP host. The mole ratio of β-cyclodextrin (β-CD) unit in CDP to HY was determined as 2:1. At 25 °C, the dissociated constant of HY-CDP was measured as 1.47×10(-7) mol L(-1) by UV-vis spectroscopy. In the formation of inclusion complexes, CDP could overcome the β-CD drawbacks - such as the poor water-solubility and the restriction of single cavity size, indicating it was able to use as a universal solubilizer for pharmaceutical application.
authors.affiliation: College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, Jiangsu, PR China.
authors.forename: Wang
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Gong
authors.forename: Yin
authors.initials: Y
authors.lastname: Cai
authors.forename: Chuanli
authors.initials: C
authors.lastname: Zhang
authors.forename: Xing
authors.initials: X
authors.lastname: Yu
authors.forename: Jian
authors.initials: J
authors.lastname: Fan
authors.forename: Guowang
authors.initials: G
authors.lastname: Diao
mesh_terms: D000873:Anthracenes; D002482:Cellulose / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000873:Anthracenes; D003505:Cyclodextrins; D047392:beta-Cyclodextrins; C041953:cyclodextrin polymer; D014867:Water; D010569:Perylene; C004965:hypericin; D002482:Cellulose; C031215:betadex