title: Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder.
abstract: Alterations in catechol-O-methyltransferase (COMT) activity are involved in various types of neurological disorders. We examined a possible association between the COMT Val158Met polymorphism and conversion disorder in a study of 48 patients with conversion disorder and 48 control patients. In the conversion disorder group, 31 patients were Val/Met heterozygotes, 15 patients were Val/Val homozygotes and 2 patients were Met/Met homozygotes. In the control group, 32 patients were Val/Met heterozygotes and 16 patients were Val/Val homozygotes. There was no significant difference between the groups. We conclude that the COMT Val158Met genotype is quite common in Turkey and that it is not a risk factor for conversion disorder in the Turkish population.
authors.affiliation: Department of Emergency Medicine, Faculty of Medicine, Uludag University, Bursa, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Armagan
authors.forename: M L
authors.initials: ML
authors.lastname: Almacıoglu
authors.forename: T
authors.initials: T
authors.lastname: Yakut
authors.forename: A
authors.initials: A
authors.lastname: Köse
authors.forename: M
authors.initials: M
authors.lastname: Karkucak
authors.forename: O
authors.initials: O
authors.lastname: Köksal
authors.forename: O
authors.initials: O
authors.lastname: Görükmez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D016009:Chi-Square Distribution; D003291:Conversion Disorder / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014421:Turkey; D055815:Young Adult
chemical_list: D002394:Catechol O-Methyltransferase