title: Tumour markers in peritoneal washing fluid - contribution to cytology.
abstract: BACKGROUND
  Peritoneal washing cytology (PWC) that shows the microscopic intra-peritoneal spread of gynaecologic cancers is not used in staging but is known as prognostic factor and effective in planning the intensity of the therapy. False negative or false positive results clearly affect the ability to make the best decision for therapy. In this study we assessed levels of tumour markers, carcinoembryonic antigen (CEA), cancer antigen 125 (CA-125) and carbohydrate antigen (CA19-9), in peritoneal washing fluid to establish any possible contribution to the peritoneal washing cytology in patients operated for gynaecologic cancer.
  
  
  METHODS
  Preoperative tumour markers were studied in serum of blood samples obtained from the patients for preoperative evaluation of a gynaecologic operation. In the same group peritoneal tumour markers were studied in the washing fluid obtained for intraoperative cytological evaluation.
  
  
  RESULTS
  This study included a total of 94 patients, 62 with malignant and 32 with benign histopathology. The sensitivity of the cytological examination was found to be 21% with a specificity of 100%. When evaluated with CEA the sensitivity of the cytological examination has increased to 37%.
  
  
  CONCLUSIONS
  In addition to examination of PWC, the level of CEA, a tumour marker, in peritoneal washing fluid can make a diagnostic contribution. Determining the level of CEA in peritoneal washing fluid will be useful in the management of gynaecologic cancers.
authors.affiliation: Department of Medical Oncology, Ministry of Health Batman Regional Govermant Hospital, Batman, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yıldırım
authors.forename: Dınc
authors.initials: D
authors.lastname: Suren
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yıldız
authors.forename: Arsenal Sezgın
authors.initials: AS
authors.lastname: Alikanoglu
authors.forename: Vildan
authors.initials: V
authors.lastname: Kaya
authors.forename: Suleyman Gunhan
authors.initials: SG
authors.lastname: Doluoglu
authors.forename: Ozgur
authors.initials: O
authors.lastname: Aydın
authors.forename: Necat
authors.initials: N
authors.lastname: Yılmaz
authors.forename: Cem
authors.initials: C
authors.lastname: Sezer
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karaca
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood*; D018394:CA-125 Antigen / Q000032:analysis; D018395:CA-19-9 Antigen / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D003581:Cytodiagnosis; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010529:Peritoneal Cavity / Q000166:cytology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen