title: (18)F-FDG PET/CT imaging of metastatic atypical fibroxanthoma.
abstract: We report the F-FDG PET/CT appearance of a metastatic biopsy-proven malignant fibroxanthoma of the ankle. A 41-year-old female patient with a history of scleroderma presented with a fungating mass in the left ankle. Shave biopsy of the overlying skin showed atypical fibroxanthoma (AFX). Staging FDG PET/CT demonstrated a hypermetabolic exophytic soft tissue mass in the left ankle with local extension to bone and widespread metastatic disease including pulmonary parenchyma, nodes, bone marrow, and skeletal muscle. While rare, knowledge of the potential aggressive nature of AFX is important for accurate diagnosis.
authors.affiliation: LAC+USC Medical Center Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA. sindusheth@yahoo.com
authors.forename: Sindu
authors.initials: S
authors.lastname: Sheth
authors.forename: Andrew
authors.initials: A
authors.lastname: Kim
authors.forename: William D
authors.initials: WD
authors.lastname: Bishop
authors.forename: Shahram
authors.initials: S
authors.lastname: Bonyadlou
authors.forename: Robert
authors.initials: R
authors.lastname: Henderson
mesh_terms: D000328:Adult; D000842:Ankle / Q000000981:diagnostic imaging / Q000473:pathology; D001706:Biopsy; D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D005350:Fibroma / Q000000981:diagnostic imaging* / Q000473:pathology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D064847:Multimodal Imaging; D009362:Neoplasm Metastasis; D011859:Radiography; D011877:Radionuclide Imaging; D014973:Xanthomatosis / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D019788:Fluorodeoxyglucose F18