title: Effect of nanoscale-ZnO on the mechanical property and biocompatibility of electrospun poly(L-lactide) acid/nanoscale-ZnO mats.
abstract: Poly(L-lactide) acid (PLLA) was mixed with different content of nanoscale-ZnO (N-ZnO) and spun into nonwoven mats by electrospinning, the effects of the blending ratio of N-ZnO on mats morphology and mechanical properties were investigated. The prepared mats were characterized with infrared spectrometry (IR), Brunauer-Emmett-Teller (BET) surface area, the morphology and tensile test were investigated by scanning electron microscope (SEM) and electronic universal testing machine, respectively. The quantity of N-ZnO contained in mats was determinated by Na2 EDTA titration method, then the N-ZnO loading coefficient (%, NL) could be figured out. Infrared spectrometry showed that the electrospun PLLA/N-ZnO mats were prepared successfully. When the concentration of N-ZnO contained in the mats increased from 0 to 2% (w/v), the curves of stress-strain indicated that the elastic modulus of mats ranged among 5.16 to 15.59 MPa. In addition, the electrospun PLLA/N-ZnO exhibited lower cell proliferation for UE7T-13 cells than electrospun PLLA mats and control. The results presented that the N-ZnO added in the mats enhanced the toughness of PLLA/ZnO mats to some extent, though the biocompatibility of blends was not good.
authors.affiliation: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Nanjing 210096, P.R. China.
authors.forename: Xuyuan
authors.initials: X
authors.lastname: Ji
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.forename: Lingling
authors.initials: L
authors.lastname: Guo
authors.forename: Jiangqiang
authors.initials: J
authors.lastname: Xiao
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Li
authors.forename: Liming
authors.initials: L
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Deng
authors.forename: Nongyue
authors.initials: N
authors.lastname: He
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D055119:Elastic Modulus / Q000187:drug effects; D006801:Humans; D008422:Materials Testing / Q000379:methods*; D055595:Mechanical Phenomena / Q000187:drug effects; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D013055:Spectrophotometry, Infrared; D014914:Whole Blood Coagulation Time; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide); D015034:Zinc Oxide