title: Volumetric-modulated arc therapy in postprostatectomy radiotherapy patients: a planning comparison study.
abstract: The purpose of this study was to compare postprostatectomy planning for volumetric-modulated arc therapy (VMAT) with both single arc (SA) and double arcs (DA) against dynamic sliding window intensity-modulated radiotherapy (IMRT). Ten cases were planned with IMRT, SA VMAT, and DA VMAT. All cases were planned to achieve a minimum dose of 68Gy to 95% of the planning target volume (PTV) and goals to limit rectal volume >40Gy to 35% and >65Gy to 17%, and bladder volumes >40Gy to 50% and >65Gy to 25%. Plans were averaged across the 10 patients and compared for mean dose, conformity, homogeneity, rectal and bladder doses, and monitor units. The mean dose to the clinical target volume and PTV was significantly higher (p<0.05) for SA compared with DA or IMRT. The homogeneity index was not significantly different: SA = 0.09; DA = 0.08; and IMRT = 0.07. The rectal V40 was lowest for the DA plan. The rectal V20 was significantly lower (p<0.05) for both the VMAT plans compared with IMRT. There were no significant differences for bladder V40 or rectal and bladder V65. The IMRT plans required 1400MU compared with 745 for DA and 708 for SA. This study shows that for equivalent dose coverage, SA and DA VMAT plans result in higher mean doses to the clinical target volume and PTV. This greater dose heterogeneity is balanced by improved low-range rectal doses and halving of the monitor units.
authors.affiliation: Radiation Oncology Department, Northern Sydney Cancer Centre, St Leonards, New South Wales, Australia. eforde@tcd.ie
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Forde
authors.forename: Andrew
authors.initials: A
authors.lastname: Kneebone
authors.forename: Regina
authors.initials: R
authors.lastname: Bromley
authors.forename: Linxin
authors.initials: L
authors.lastname: Guo
authors.forename: Peter
authors.initials: P
authors.lastname: Hunt
authors.forename: Thomas
authors.initials: T
authors.lastname: Eade
mesh_terms: D006801:Humans; D008297:Male; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated
keywords: IMRT; Postprostatectomy radiotherapy; Volumetric-modulated arc therapy