title: Concurrent multiscale imaging with magnetic resonance imaging and optical coherence tomography.
abstract: We develop a novel platform based on a tele-operated robot to perform high-resolution optical coherence tomography (OCT) imaging under continuous large field-of-view magnetic resonance imaging (MRI) guidance. Intra-operative MRI (iMRI) is a promising guidance tool for high-precision surgery, but it may not have sufficient resolution or contrast to visualize certain small targets. To address these limitations, we develop an MRI-compatible OCT needle probe, which is capable of providing microscale tissue architecture in conjunction with macroscale MRI tissue morphology in real time. Coregistered MRI/OCT images on ex vivo chicken breast and human brain tissues demonstrate that the complementary imaging scales and contrast mechanisms have great potential to improve the efficiency and the accuracy of iMRI procedure.
authors.affiliation: University of Maryland, Fischell Department of Bioengineering, College Park, Maryland 20742, USA.
authors.forename: Chia-Pin
authors.initials: CP
authors.lastname: Liang
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Il Kyoon
authors.initials: IK
authors.lastname: Kim
authors.forename: George
authors.initials: G
authors.lastname: Makris
authors.forename: Jaydev P
authors.initials: JP
authors.lastname: Desai
authors.forename: Rao P
authors.initials: RP
authors.lastname: Gullapalli
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000033:anatomy & histology; D002645:Chickens; D004867:Equipment Design; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D018482:Muscle, Skeletal / Q000033:anatomy & histology; D012371:Robotics; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*