title: p63 and p53 expression in extranodal NK/T cell lymphoma, nasal type.
abstract: OBJECTIVE
  To investigate the pathological and clinical meaning of p63 in extranodal nasal type NK/T cell lymphoma (NKTCL).
  
  
  METHODS
  We detected p63 and p53 expression using immunohistochemistry staining in 84 cases of NKTCL from Southern of China, an area with a well known high incidence of nasopharyngeal carcinoma, which is closely associated with Epstein-Barr virus infection. Moreover, we analysed the relationship between p63 and p53 expression and the clinicopathological features of NKTCL.
  
  
  RESULTS
  Our results first showed that p63 expression was found in 14.3% (12/84) of NKTCL compared with 6.6% (2/30) in reactive lymphoid hyperplasia of nasopharynx. p63 Expression rate in NKTCL was significantly higher than that in reactive lymphoid hyperplasia of nasopharynx (p=0.016). NKTCL patients with p63 positivity had poorer 5-year overall survival rate (29.2%) than that (49.9%) of p63 negativity. p53 expression was found in 33.3% (28/84) of NKTCL. Our data showed that p53 expression was significantly associated with tumour stage (p=0.016) and international prognostic index (p=0.026) in patients with NKTCL. Cox regression test showed that p53 expression rate and international prognostic index score were statistically independent prognostic factors for NKTCL patients (p=0.002 and p=0.016, respectively). Our results suggest that p63 and p53 might play a role in pathogenesis of NKTCL.
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Ziyin
authors.initials: Z
authors.lastname: Ye
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Cao
authors.forename: Gang
authors.initials: G
authors.lastname: Niu
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Liang
authors.forename: Yongdong
authors.initials: Y
authors.lastname: Liu
authors.forename: Lili
authors.initials: L
authors.lastname: Jiang
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Yu
authors.forename: Anjia
authors.initials: A
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D006965:Hyperplasia; D054391:Lymphoma, Extranodal NK-T-Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009305:Nasopharynx / Q000473:pathology; D012367:RNA, Viral / Q000378:metabolism; D012189:Retrospective Studies; D014157:Transcription Factors / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D055815:Young Adult
chemical_list: D012367:RNA, Viral; C115051:TP63 protein, human; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins
keywords: IMMUNOHISTOCHEMISTRY; LYMPHOMA; P53