title: Evidence-based prevention and surgical treatment of necrotizing enterocolitis-a review of randomized controlled trials.
abstract: Necrotizing enterocolitis remains a common cause of morbidity and mortality in the neonatal period. Despite many advances in the management of the critically ill neonate, the exact etiology, attempts at prevention and determining best treatment for NEC have been elusive. Unfortunately, the overall survival for this poorly understood and complex condition has not improved. NEC is a condition that can and should be studied with randomized prospective trials (RCTs). This chapter reviews the current evidence-based trials for this condition thus far performed.
authors.affiliation: Division of Pediatric Surgery, Nationwide Children's Hospital, The Ohio State College of Medicine, The Ohio State University, 700 Children's Dr, Columbus, Ohio 43205, USA.
authors.forename: Mehul V
authors.initials: MV
authors.lastname: Raval
authors.forename: Nigel J
authors.initials: NJ
authors.lastname: Hall
authors.forename: Agostino
authors.initials: A
authors.lastname: Pierro
authors.forename: R Lawrence
authors.initials: RL
authors.lastname: Moss
mesh_terms: D001942:Breast Feeding; D004322:Drainage; D020345:Enterocolitis, Necrotizing / Q000517:prevention & control* / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000517:prevention & control* / Q000601:surgery*; D007813:Laparotomy; D019936:Probiotics / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic