title: Patient-specific microRNA expression profiles as a marker for minimal residual disease in acute myeloid leukemia.
abstract: MicroRNAs are a class of small noncoding RNAs playing a crucial role in physiological and pathological conditions, including acute myeloid leukemia. We aimed at examining whether in clinical settings the identification of patient-specific leukemia-associated profiles (LAMPs) of overexpressed microRNAs could be used for minimal residual disease (MRD) detection. Patients with identified LAMPs at diagnosis were further tested for the presence of LAMP after induction therapy. Those with identifiable MRD defined by LAMP expression after induction showed a trend toward a shorter overall survival. Larger studies are needed to confirm the utility of patient-specific LAMPs for MRD follow-up.
authors.forename: Velizar
authors.initials: V
authors.lastname: Shivarov
authors.forename: Angel
authors.initials: A
authors.lastname: Stoimenov
authors.forename: Branimir
authors.initials: B
authors.lastname: Spassov
authors.forename: Svetlana
authors.initials: S
authors.lastname: Angelova
authors.forename: Monika
authors.initials: M
authors.lastname: Niagolov
authors.forename: Milena
authors.initials: M
authors.lastname: Ivanova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D018365:Neoplasm, Residual; D011379:Prognosis; D055815:Young Adult
chemical_list: D035683:MicroRNAs
keywords: AML; MRD; MicroRNA expression profiling