title: Terpenoids from the Chinese liverwort Plagiochila pulcherrima and their cytotoxic effects.
abstract: Three new pimarane-type diterpenoids, 7β,11α-dihydroxypimara-8(14),15-diene (1), 1β,11α-dihydroxypimara-8(14),15-diene (2), and 11α-hydroxypimara-8(14),15-diene (3), five 2,3-secoaromadendrane-type sesquiterpenoids, including a new one, ethyoxyplagiochiline A2 (4), and three known fusicoccane-type diterpenoids were isolated from the Chinese liverwort Plagiochila pulcherrima. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 6 and 7 exhibited moderate inhibitory activity on the proliferation of human cancer cell lines Hela, A172, and H460. Moreover, the cytotoxicity of compound 6 to Hela cells was related to apoptotis as confirmed by DAPI nuclear staining and flow cytometry.
authors.affiliation: Key Lab of Chemical Biology of Ministry of Education, Department of Natural Products Chemistry, Shandong University, Jinan 250012, China.
authors.forename: Song
authors.initials: S
authors.lastname: Wang
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Liu
authors.forename: Zhao-Min
authors.initials: ZM
authors.lastname: Lin
authors.forename: Rui-Juan
authors.initials: RJ
authors.lastname: Li
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.forename: Jin-Chuan
authors.initials: JC
authors.lastname: Zhou
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D004224:Diterpenes; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D035926:Hepatophyta / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
chemical_list: C582500:11alpha-hydroxypimara-8(14),15-diene; C582501:1beta,11alpha-dihydroxypimara-8(14),15-diene; C582499:7beta,11alpha-dihydroxypimara-8(14),15-diene; D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C433018:pimarane