title: Amidine-based bioactive compounds for the regulation of arginine metabolism.
abstract: In the research of new bioactive compounds able to regulate the L-arginine metabolism, several substituted amidines were disclosed as potent and selective inhibitors of mainly three enzyme families: the nitric oxide synthase, the dimethylarginine dimethylaminohydrolase and the peptidylarginine deiminase. The present work is focused on the last five years developments in the research for amidine-based inhibitors of the mentioned enzymes and on their potential usefulness in neurodegenerative, inflammatory and autoimmune disorders.
authors.affiliation: Dipartimento di Farmacia, Università G. d'Annunzio, Chieti, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Maccallini
authors.forename: Marialuigia
authors.initials: M
authors.lastname: Fantacuzzi
authors.forename: Rosa
authors.initials: R
authors.lastname: Amoroso
mesh_terms: D000578:Amidines / Q000737:chemistry*; D001120:Arginine / Q000378:metabolism*; D006801:Humans
chemical_list: D000578:Amidines; D001120:Arginine