title: Retroperitoneal amyloidosis as the presenting manifestation of Waldenstrom's macroglobulinaemia.
abstract: Retroperitoneal amyloidosis has been described in a few case reports and is typically a secondary manifestation of inflammation or malignancy. We present the case of a 69-year-old man who presented with a large pleural effusion and an incidental retroperitoneal mass in the CT imaging. Further investigation confirmed the diagnosis of amyloid amyloidosis involving the retroperitoneum as well as a concurrent Waldenstrom's macroglobulinaemia. Chemotherapy consistent of drugs active against both the lymphoid and plasma cell components of the disease is the proposed therapy for Waldenstrom's macroglobulinaemia in those patients amenable to receive chemotherapy and can make a difference in the survival.
authors.affiliation: Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA. dfrancopalacios@gmail.com
authors.forename: Domingo
authors.initials: D
authors.lastname: Franco-Palacios
authors.forename: Maher
authors.initials: M
authors.lastname: Tama
authors.forename: Suprotim
authors.initials: S
authors.lastname: Samaddar
authors.forename: Jay
authors.initials: J
authors.lastname: Yang
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis* / Q000188:drug therapy*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001707:Biopsy, Needle; D002853:Chromatography, Liquid; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D006801:Humans; D033162:Incidental Findings; D008297:Male; D010996:Pleural Effusion / Q000000981:diagnostic imaging; D012187:Retroperitoneal Space; D053719:Tandem Mass Spectrometry; D014057:Tomography, X-Ray Computed; D008258:Waldenstrom Macroglobulinemia / Q000175:diagnosis* / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents