title: Genotoxicity and oxidative stress in gasoline station attendants.
abstract: We evaluated genotoxic effects of exposure to low levels of benzene, a class I human carcinogen, among gasoline station attendants (GSA). Oxidative stress and the protective effects of antioxidants on DNA damage were also analyzed. Although exposures were below ACGIH (American Conference of Governmental Industrial Hygienists) limits, the GSA group presented higher DNA damage indices and micronucleus frequencies, increased oxidative protein damage, and decreased antioxidant capacity relative to the control group. Duration of benzene exposure was correlated with DNA and protein damage. The biomarkers evaluated in this work may provide early signals of damage in subjects occupationally exposed to benzene.
authors.affiliation: Laboratory of Toxicology LATOX, Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Angela M
authors.initials: AM
authors.lastname: Moro
authors.forename: Mariele F
authors.initials: MF
authors.lastname: Charão
authors.forename: Natália
authors.initials: N
authors.lastname: Brucker
authors.forename: Juliano
authors.initials: J
authors.lastname: Durgante
authors.forename: Marília
authors.initials: M
authors.lastname: Baierle
authors.forename: Guilherme
authors.initials: G
authors.lastname: Bubols
authors.forename: Gabriela
authors.initials: G
authors.lastname: Goethel
authors.forename: Rafael
authors.initials: R
authors.lastname: Fracasso
authors.forename: Sabrina
authors.initials: S
authors.lastname: Nascimento
authors.forename: Rachel
authors.initials: R
authors.lastname: Bulcão
authors.forename: Bruna
authors.initials: B
authors.lastname: Gauer
authors.forename: Anelise
authors.initials: A
authors.lastname: Barth
authors.forename: Guilherme
authors.initials: G
authors.lastname: Bochi
authors.forename: Rafael
authors.initials: R
authors.lastname: Moresco
authors.forename: Adriana
authors.initials: A
authors.lastname: Gioda
authors.forename: Mirian
authors.initials: M
authors.lastname: Salvador
authors.forename: Sandra
authors.initials: S
authors.lastname: Farsky
authors.forename: Solange C
authors.initials: SC
authors.lastname: Garcia
mesh_terms: D001554:Benzene / Q000633:toxicity; D005742:Gasoline; D006801:Humans; D009152:Mutagenicity Tests; D016273:Occupational Exposure; D018384:Oxidative Stress
chemical_list: D005742:Gasoline; D001554:Benzene