title: Pityriasis lichenoides chronica associated with use of HMG-CoA reductase inhibitors.
abstract: Herein, we present three cases of Pityriasis lichenoides chronica (PLC) in patients who developed the rash after use of 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase inhibitors. The patients had complete resolution after standard treatment by dermatologists and withdrawal of the offending agents. In one case, the patient had a previous episode of a similar rash that occurred with HMG-CoA reductase inhibitors use many years previously. Pityriasis lichenoides chronica is a condition of unknown aetiology. Several agents have been associated with its presentation. We postulate HMG-CoA reductase inhibition in skin presents a final common pathway for the presentation of PLC in select patients.
authors.affiliation: Cardiac Unit, The Queen Elizabeth Hospital, St Michael, Barbados, West Indies. jeffmassay@gmail.com
authors.forename: R J B
authors.initials: RJ
authors.lastname: Massay
authors.forename: A A
authors.initials: AA
authors.lastname: Maynard
mesh_terms: D000368:Aged; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D017514:Pityriasis Lichenoides / Q000139:chemically induced*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors