title: Double filtration plasmapheresis for a case of Crimean-Congo hemorrhagic fever.
abstract: Crimean-Congo hemorrhagic fever (CCHF), is a fatal viral infection transmitted to humans through a tick bite or exposure to blood or tissues of viremic hosts. The clinical presentation is characterized by sudden onset high fever, headache, myalgia, abdominal pain and nausea-vomiting followed by gastrointestinal, urinary, respiratory tract and brain hemorrhage. Laboratory findings include leucopenia, thrombocytopenia, elevated liver enzymes, prolonged prothrombin time and activated partial thromboplastin time. We report a case of CCHF who was treated with a combination of DFPP and ribavirin therapy. As a result of this multimodal treatment, patient's clinical symptoms and laboratory findings improved gradually.
authors.affiliation: Ankara University, Faculty of Medicine Anesthesiology and ICM Department, Turkey. basakceyda@hotmail.com
authors.forename: Başak C
authors.initials: BC
authors.lastname: Meço
authors.forename: Osman
authors.initials: O
authors.lastname: Memikoğlu
authors.forename: Osman
authors.initials: O
authors.lastname: Ilhan
authors.forename: Erol
authors.initials: E
authors.lastname: Ayyıldız
authors.forename: Ceren
authors.initials: C
authors.lastname: Gunt
authors.forename: Necmettin
authors.initials: N
authors.lastname: Unal
authors.forename: Mehmet
authors.initials: M
authors.lastname: Oral
authors.forename: Melek
authors.initials: M
authors.lastname: Tulunay
mesh_terms: D000328:Adult; D000818:Animals; D005340:Fibrinogen / Q000096:biosynthesis; D005374:Filtration; D003225:Hemorrhagic Fever Virus, Crimean-Congo; D006479:Hemorrhagic Fever, Crimean / Q000628:therapy*; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D010956:Plasmapheresis / Q000379:methods*; D012254:Ribavirin / Q000627:therapeutic use; D064927:Tick Bites; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D012254:Ribavirin; D005340:Fibrinogen