title: Yeast cell wall supplementation alters the metabolic responses of crossbred heifers to an endotoxin challenge.
abstract: This study examined the effect of feeding yeast cell wall (YCW) products on the metabolic responses of newly-received feedlot cattle to an endotoxin challenge. Heifers were separated into treatment groups receiving either a Control diet, YCW-A or YCW-C, and were fed for 52 d. Heifers were weighed on d 0, 14, 36, 38 and 52. On d 37 heifers were challenged i.v. with LPS [0.5 µg/kg body weight (BW)] and blood samples were collected relative to LPS challenge. Heifer BW increased from d 0 to 36 and from d 38 to 52, but was not affected by treatment. Post-LPS, glucose concentrations increased and were less in YCW-A than Control and YCW-C heifers. Pre-LPS, insulin concentrations were greater in YCW-A and YCW-C than Control heifers. Post-LPS, insulin concentrations increased with YCW-C having greater insulin than Control heifers. Pre-LPS, NEFA concentrations tended to be less in YCW-C than Control heifers. Post-LPS non-esterified fatty acids (NEFA) concentrations were less in YCW-C than Control and YCW-A heifers. Post-LPS, blood urea nitrogen (BUN) concentrations were greater in YCW-A than Control and YCW-C. These data indicate, based on NEFA and BUN data, that certain YCW products can enhance energy metabolism during an immune challenge without causing lipolysis or muscle catabolism.
authors.affiliation: 1USDA-ARS, Livestock Issues Research Unit, Lubbock, TX, USA.
authors.forename: Nicole C Burdick
authors.initials: NC
authors.lastname: Sanchez
authors.forename: Tanner R
authors.initials: TR
authors.lastname: Young
authors.forename: Jeffery A
authors.initials: JA
authors.lastname: Carroll
authors.forename: Jimmie R
authors.initials: JR
authors.lastname: Corley
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Rathmann
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Johnson
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D001947:Breeding; D002417:Cattle; D002473:Cell Wall / Q000276:immunology / Q000378:metabolism*; D045424:Complex Mixtures / Q000008:administration & dosage*; D019587:Dietary Supplements; D004731:Endotoxins / Q000008:administration & dosage* / Q000276:immunology; D004734:Energy Metabolism / Q000187:drug effects; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000097:blood; D015003:Yeasts
chemical_list: D045424:Complex Mixtures; D004731:Endotoxins; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D005947:Glucose
keywords: Cattle; LPS; feedlot; metabolism; yeast cell wall