title: Selective cavitand-mediated endocytosis of targeted imaging agents into live cells.
abstract: A water-soluble synthetic receptor molecule is capable of selective, controlled endocytosis of a specifically tagged target molecule in different types of living human cells. The presence of suitable choline-derived binding handles is essential for the molecular recognition and transport process, allowing selective guest transport and imaging of cancer cells.
authors.affiliation: Department of Chemistry, School of Medicine, University of California, Riverside, California 92521, USA.
authors.forename: Yoo-Jin
authors.initials: YJ
authors.lastname: Ghang
authors.forename: Michael P
authors.initials: MP
authors.lastname: Schramm
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Roger A
authors.initials: RA
authors.lastname: Acey
authors.forename: Clement N
authors.initials: CN
authors.lastname: David
authors.forename: Emma H
authors.initials: EH
authors.lastname: Wilson
authors.forename: Yinsheng
authors.initials: Y
authors.lastname: Wang
authors.forename: Quan
authors.initials: Q
authors.lastname: Cheng
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Hooley
mesh_terms: D002460:Cell Line; D045744:Cell Line, Tumor; D002794:Choline / Q000737:chemistry / Q000378:metabolism*; D016503:Drug Delivery Systems; D004705:Endocytosis; D004988:Ethers, Cyclic / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D012118:Resorcinols / Q000737:chemistry / Q000378:metabolism*; D012995:Solubility
chemical_list: D004988:Ethers, Cyclic; D012118:Resorcinols; C442939:cavitand; D002794:Choline