title: Predicting the successful peripheral blood stem cell harvesting.
abstract: Several previously defined factors affecting the mobilization success include age, prior chemotherapy lines, exposure to myelotoxic agents, extended field radiotherapy and bone marrow infiltration with the primary disease. The purpose of this study was to retrospectively analyze the influence of the predictive factors for a successful peripheral stem cell mobilization. We enrolled a total of 145 patients into the study (non-Hodgkin lymphoma (n: 40), Hodgkin lymphoma (n: 36), myeloma (n: 64), solid tumors (n:5)) who received autologous stem cell transplantation between 2009 and 2012. In multivariate analysis only platelet count was found to be related with mobilization outcome (p<0.05). Knowing predictive factors for successful mobilization may be useful to define the best timing for mobilization and the most appropriate mobilizing agents for proper patient population.
authors.affiliation: Ankara Oncology Education and Research Hospital, Hematology and Stem Cell Transplantation Clinic, Ankara, Turkey. dritir@hotmail.com
authors.forename: Itır Şirinoğlu
authors.initials: IŞ
authors.lastname: Demiriz
authors.forename: Sinem Civriz
authors.initials: SC
authors.lastname: Bozdağ
authors.forename: Emre
authors.initials: E
authors.lastname: Tekgündüz
authors.forename: Bilge
authors.initials: B
authors.lastname: Uğur
authors.forename: Gamze
authors.initials: G
authors.lastname: Durgun
authors.forename: Serife
authors.initials: S
authors.lastname: Koçubaba
authors.forename: Fevzi
authors.initials: F
authors.lastname: Altuntaş
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000477:Alkylating Agents / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D001781:Blood Component Removal / Q000379:methods; D001792:Blood Platelets / Q000166:cytology; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy; D015999:Multivariate Analysis; D009369:Neoplasms / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000477:Alkylating Agents; D000970:Antineoplastic Agents