title: Glucagon-Like Peptide-1 Receptor Imaging with [Lys (40) (Ahx-HYNIC- (99 m) Tc/EDDA)NH 2 ]-Exendin-4 for the Diagnosis of Recurrence or Dissemination of Medullary Thyroid Cancer: A Preliminary Report.
abstract: Introduction. Epidemiological studies on medullary thyroid cancer (MTC) have shown that neither a change in stage at diagnosis nor improvement in survival has occurred during the past 30 years. In patients with detectable serum calcitonin and no clinically apparent disease, a careful search for local recurrence, and nodal or distant metastases, should be performed. Conventional imaging modalities will not show any disease until basal serum calcitonin is at least 150 pg/mL. The objective of the study was to present the first experience with labelled glucagon-like peptide-1 (GLP-1) analogue [Lys(40)(Ahx-HYNIC-(99m)Tc/EDDA)NH2]-exendin-4 in the visualisation of MTC in humans. Material and Method. Four patients aged 22-74 years (two with sporadic and two with MEN2 syndrome-related disseminated MTC) were enrolled in the study. In all patients, GLP-1 receptor imaging was performed. Results. High-quality images were obtained in all patients. All previously known MTC lesions have been confirmed in GLP-1 scintigraphy. Moreover, one additional liver lesion was detected in sporadic MTC male patient. Conclusions. GLP-1 receptor imaging with [Lys(40)(Ahx-HYNIC-(99m)Tc/EDDA)NH2]-exendin-4 is able to detect MTC lesions. GLP-1 scintigraphy can serve as a confirmatory test in MTC patients, in whom other imaging procedures are inconsistent.
authors.affiliation: Department of Endocrinology, Jagiellonian University Medical College, Kopernika 17, 31-501 Krakow, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Pach
authors.forename: A
authors.initials: A
authors.lastname: Sowa-Staszczak
authors.forename: A
authors.initials: A
authors.lastname: Jabrocka-Hybel
authors.forename: A
authors.initials: A
authors.lastname: Stefańska
authors.forename: M
authors.initials: M
authors.lastname: Tomaszuk
authors.forename: R
authors.initials: R
authors.lastname: Mikołajczak
authors.forename: B
authors.initials: B
authors.lastname: Janota
authors.forename: M
authors.initials: M
authors.lastname: Trofimiuk-Müldner
authors.forename: E
authors.initials: E
authors.lastname: Przybylik-Mazurek
authors.forename: A
authors.initials: A
authors.lastname: Hubalewska-Dydejczyk