title: [New research progress on atrophic nonunion].
abstract: Occurance of atrophic nonunion is a complex process. Previous studies suggested that atrophic nonunion was mainly due to lack of blood supply of fracture fragments, but recent studies found that blood supply was not deficiency in middle and late stages, indicating that decreased osteogenic factors and blood supply in early stages might play an important role in morbidity. Current effective treatment measures for atrophic nonunion mainly include bone graft and fixation,physical therapy, local injection therapy. All-round preventive could reduce incidence of atrophic nonunion. Atrophic nonunion is still a troublesome complication of fractures in orthopaedics, and more attention should be paid for its effective prevention and treatment. The paper summarized recent original articles about atrophic nonunion and reviewed the occurrence mechanisms, diagnosis, prevention and treatment measures of this disease.
authors.affiliation: Department of Orthopaedics, Chinese PLA General Hospital, Beijing, 100853, China.
authors.forename: Jun-Qiang
authors.initials: JQ
authors.lastname: Wei
authors.forename: Bo-Xun
authors.initials: BX
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.forename: Pei-Fu
authors.initials: PF
authors.lastname: Tang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001284:Atrophy / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D017102:Fracture Healing / Q000187:drug effects; D050723:Fractures, Bone / Q000473:pathology*; D006801:Humans