title: NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease.
abstract: Host defense requires the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and the induction of pyroptotic cell death, which depends on the activation of inflammatory Caspases within inflammasomes by innate immune cells. Several cytosolic pattern recognition receptors (PRRs) have been implicated in this process in response to infectious and sterile agonists. Here we summarize the current knowledge on inflammasome-organizing PRRs, emphasizing the recently described NLRP7, and their implications in human disease.
authors.affiliation: Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Radian
authors.forename: Lucia
authors.initials: L
authors.lastname: de Almeida
authors.forename: Andrea
authors.initials: A
authors.lastname: Dorfleutner
authors.forename: Christian
authors.initials: C
authors.lastname: Stehlik
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D003141:Communicable Diseases / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D058847:Inflammasomes / Q000276:immunology* / Q000378:metabolism; D008659:Metabolic Diseases / Q000276:immunology* / Q000473:pathology*; D008954:Models, Biological; D051192:Receptors, Pattern Recognition / Q000276:immunology* / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D058847:Inflammasomes; C502448:NLRP7 protein, human; D051192:Receptors, Pattern Recognition
keywords: AIM2-like receptor; Hydatidiform mole; Inflammasome; Inflammation; Nod-like receptor; Pattern recognition receptor