title: [Regulation of Toll-like receptors-dependent inflammatory response].
abstract: Toll-like receptors (TLRs) are a pivotal part of our innate immune response. They recognize a wide variety of pathogens and instigate an immune response, thus facilitating the removal of the disease-causing agent. Due to the intense nature of this response its strict control is of key importance, as a prolonged inflammatory signal leads to carcinogenesis and autoimmune disorders. The signaling cascade initiated by the activated TLR is complex and consists of multiple stages. It involves a variety of adaptor proteins, protein kinases and effector transcription factors. The number of stages in this process enables many possible checkpoints and ways of regulation. Signal modulation involves differentiated expression of TLRs, splicing variants of their adaptor proteins, enzymes modifying proteins engaged in the cascade and many more. This review focuses on endogenous factors responsible for controlling the TLR-dependent inflammatory response as well as on pharmacological therapies designed for regulating the innate immune response.
authors.affiliation: Instytut Immunologii i Terapii Doświadczalnej Polskiej Akademii Nauk im. Ludwika Hirszfelda, Wrocław, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Kowalczyk
authors.forename: Jakub
authors.initials: J
authors.lastname: Siednienko
authors.forename: Janusz
authors.initials: J
authors.lastname: Matuszyk
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology*; D035683:MicroRNAs / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control; D011494:Protein Kinases / Q000276:immunology / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000187:drug effects / Q000276:immunology*
chemical_list: D000893:Anti-Inflammatory Agents; D035683:MicroRNAs; D018160:Receptors, Cytoplasmic and Nuclear; D051193:Toll-Like Receptors; C099713:nuclear receptor subfamily 0, group B, member 2; D011494:Protein Kinases