title: Antibiotic-loaded acrylic bone cements: an in vitro study on the release mechanism and its efficacy.
abstract: An in vitro study was carried out in order to investigate the antibiotic release mechanism and the antibacterial properties of commercially (Palacos® R+G and Palacos® LV+G) and manually (Palacos® R+GM and Palacos® LV+GM) blended gentamicin-loaded bone cements. Samples were characterized by means of scanning electron microscopy (SEM) and compression strength was evaluated. The antibiotic release was investigated by dipping sample in simulated body fluid (SBF) and periodically analyzing the solution by means of high pressure liquid chromatography (HPLC). Different antibacterial tests were performed to investigate the possible influence of blending technique on antibacterial properties. Only some differences were observed between gentamicin manually added and commercial ones, in the release curves, while the antibacterial effect and the mechanical properties seem to not feel the blending technique.
authors.affiliation: Applied Science and Technology Department, Politecnico di Torino, Italy. marta.miola@polito.it
authors.forename: Marta
authors.initials: M
authors.lastname: Miola
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bistolfi
authors.forename: Maria Carmen
authors.initials: MC
authors.lastname: Valsania
authors.forename: Carlotta
authors.initials: C
authors.lastname: Bianco
authors.forename: Giacomo
authors.initials: G
authors.lastname: Fucale
authors.forename: Enrica
authors.initials: E
authors.lastname: Verné
mesh_terms: D000179:Acrylates; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001843:Bone Cements; D005839:Gentamicins / Q000008:administration & dosage*; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning
chemical_list: D000179:Acrylates; D000900:Anti-Bacterial Agents; D001843:Bone Cements; D005839:Gentamicins