title: Anaplastic large T-cell lymphoma presenting as an isolated osseous involvement: a case report and review of the literature.
abstract: This case describes a 50-year-old man with multiple lytic bone lesions involving the skull, pelvis and ribs and associated features of anaemia, hypercalcaemia, azotaemia and subsequently found to be non-Hodgkin's lymphoma of anaplastic large T cell type (ALCL) on biopsy taken from a soft tissue mass in the anterior chest wall as an aetiology. We report this case with an aim to expand our knowledge of isolated osseous involvement in case of non-Hodgkin's lymphoma. This case was unique in the sense of an isolated osseous involvement in ALCL without any organomegaly and lymphadenopathy with a normal bone marrow biopsy finding. So in rare instances, T-cell lymphoma can present with a multiple lytic lesion, anaemia, hypercalcaemia. Although B-cell non-Hodgkin's lymphoma can present with the above manifestation, it is extremely rare for T-cell non-Hodgkin's lymphoma.
authors.affiliation: Department of Medicine, Maulana Azad Medical College, New Delhi, India. drhemantnayak@gmail.com
authors.forename: Hemanta K
authors.initials: HK
authors.lastname: Nayak
authors.forename: Raizada
authors.initials: R
authors.lastname: Nishant
authors.forename: Nitin K
authors.initials: NK
authors.lastname: Sinha
authors.forename: Mradul Kumar
authors.initials: MK
authors.lastname: Daga
mesh_terms: D001706:Biopsy; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed