title: CD147 mediates chemoresistance in breast cancer via ABCG2 by affecting its cellular localization and dimerization.
abstract: CD147 and ABCG2 both have been reported to mediate Multidrug resistance (MDR) in breast cancer. Recent study demonstrates that CD147 could form a complex with ABCG2 on the cell membrane in primary effusion lymphoma. However, whether these two molecules regulate each other in breast cancer and result in MDR is not clear. We established four MCF-7 cell lines transfected with CD147 and/or ABCG2 and found that CD147 could increase the expression and dimerization of ABCG2, affect its cellular localization and regulate its drug transporter function. The findings derived from cells were confirmed subsequently in clinic samples of chemotherapy-sensitive/resistant breast cancer.
authors.affiliation: Department of Dermatology, XiangYa Hospital, Central South University, Changsha, Hunan 410008, China.
authors.forename: Shuangyuan
authors.initials: S
authors.lastname: Zhou
authors.forename: Liqiu
authors.initials: L
authors.lastname: Liao
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Weiqi
authors.initials: W
authors.lastname: Zeng
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Su
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhao
authors.forename: Mingliang
authors.initials: M
authors.lastname: Chen
authors.forename: Yehong
authors.initials: Y
authors.lastname: Kuang
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Li
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D051926:Basigin / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D061986:MCF-7 Cells; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D055503:Protein Multimerization; D021381:Protein Transport; D012313:RNA / Q000378:metabolism; D012189:Retrospective Studies; D013997:Time Factors; D014162:Transfection; D016896:Treatment Outcome
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; C497886:BSG protein, human; D009363:Neoplasm Proteins; D051926:Basigin; D012313:RNA
keywords: ABCG2; Breast cancer; CD147; Chemoresistance