title: [Study on nano-CaCO3 applicated in Xin Yue Shu Capsules preliminarily].
abstract: OBJECTIVE
  To investigate the characteristics of nano-CaCO3 applicated in Xin Yue Shu Capsules.
  
  
  METHODS
  Studied the effect of different dosages of aerosil or nano-CaCO3 on fluidity, bulk density, moisture absorption of Xin Yue Shu capsules spray drying powder. In vitro dissolution and ferulic acid stability of Xin Yue Shu capsules was observed.
  
  
  RESULTS
  It significantly improved powder fluidity and bulk density of Xin Yue Shu spray drying powder when aerosil or nano-CaCO3 was added. But there was no significant effect on powder moisture absorption, ferulic acid in vitro dissolution and ferulic acid stability.
  
  
  CONCLUSIONS
  The effect of Nano-CaCO3 on improving powder fluidity and bulk density applicated in the spray drying powder of traditional Chinese medicine deserves studying further.
authors.affiliation: College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China. jyanrong03@163.com
authors.forename: Yan-Rong
authors.initials: YR
authors.lastname: Jiang
authors.forename: Zhen-Hai
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Cui
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: He
authors.forename: Shao-Ying
authors.initials: SY
authors.lastname: Hu
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Jia
mesh_terms: D000042:Absorption; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000737:chemistry*; D002214:Capsules; D003373:Coumaric Acids / Q000737:chemistry*; D003890:Desiccation; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry*; D011208:Powders; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility
chemical_list: D002214:Capsules; D003373:Coumaric Acids; D004365:Drugs, Chinese Herbal; D011208:Powders; D012822:Silicon Dioxide; C004999:ferulic acid; D002119:Calcium Carbonate