title: [Erythrocytes and microvascular tone during acute traumatic haemorrhagic shock].
abstract: Haemorrhagic shock remains a leading cause of death in trauma patients. The concept of haematologic damage control is gradually taking place in the management of traumatic haemorrhagic shock. It is based primarily on the early implementation of a quality blood transfusion involving erythrocytes, plasmas and platelets transfusion. Red blood cell transfusion is mainly supported by the oxygen carrier properties of erythrocytes. However, it appears that erythrocytes ability to modulate the bioavailability of nitric oxide (NO) plays a major role in capillary opening and perfusion. Erythrocytes are also actively involved in the processes of hemostasis and coagulation. In this context, it seems difficult to define a threshold of hemoglobin concentration to determine the implementation of a blood transfusion in traumatic haemorrhagic shock.
authors.affiliation: Service de réanimation des urgences, pôle des urgences adultes, hôpital Pellegrin, place Raba-Léon, Bordeaux, France. nicolas.morel@chu-bordeaux.fr
authors.forename: N
authors.initials: N
authors.lastname: Morel
authors.forename: M
authors.initials: M
authors.lastname: Biais
authors.forename: F
authors.initials: F
authors.lastname: Delaunay
authors.forename: V
authors.initials: V
authors.lastname: Dubuisson
authors.forename: O
authors.initials: O
authors.lastname: Cassone
authors.forename: F
authors.initials: F
authors.lastname: Siméon
authors.forename: O
authors.initials: O
authors.lastname: Morel
authors.forename: G
authors.initials: G
authors.lastname: Janvier
mesh_terms: D000208:Acute Disease; D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D001809:Blood Viscosity; D002199:Capillary Permeability; D004730:Endothelium, Vascular / Q000503:physiopathology; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000502:physiology*; D018056:Hemorheology; D006801:Humans; D008833:Microcirculation; D023421:Models, Animal; D017942:Nitric Acid / Q000097:blood; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000378:metabolism; D010952:Plasma Substitutes / Q000627:therapeutic use; D033081:Shear Strength; D012771:Shock, Hemorrhagic / Q000097:blood* / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D012774:Shock, Traumatic / Q000097:blood* / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014655:Vascular Resistance / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology
chemical_list: D010108:Oxyhemoglobins; D010952:Plasma Substitutes; D017942:Nitric Acid; D010100:Oxygen