title: Polymer monolithic capillary microextraction combined on-line with inductively coupled plasma MS for the determination of trace rare earth elements in biological samples.
abstract: A rapid and sensitive method based on polymer monolithic capillary microextraction combined on-line with microconcentric nebulization inductively coupled plasma MS has been developed for the determination of trace/ultratrace rare earth elements in biological samples. For this purpose, the iminodiacetic acid modified poly(glycidyl methacrylate-trimethylolpropane trimethacrylate) monolithic capillary was prepared and characterized by SEM and FTIR spectroscopy. Factors affecting the extraction efficiency, such as sample pH, sample flow rate, sample/eluent volume, and coexisting ions were investigated in detail. Under the optimal conditions, the LODs for rare earth elements were in the range of 0.08 (Er) to 0.97 ng/L (Nd) with a sampling frequency of 8.5 h(-1), and the RSDs were between 1.5% (Sm) and 7.4% (Nd) (c = 20 ng/L, n = 7). The proposed method was successfully applied to the analysis of trace/ultratrace rare earth elements in human urine and serum samples, and the recoveries for the spiked samples were in the range of 82-105%. The developed method was simple, rapid, sensitive, and favorable for the analysis of trace/ultratrace rare earth elements in biological samples with limited sample volume.
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan, P R China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Beibei
authors.initials: B
authors.lastname: Chen
authors.forename: Man
authors.initials: M
authors.lastname: He
authors.forename: Bin
authors.initials: B
authors.lastname: Hu
mesh_terms: D000327:Adsorption; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D013058:Mass Spectrometry / Q000379:methods*; D008674:Metals, Rare Earth / Q000032:analysis*; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry*; D015203:Reproducibility of Results; D052617:Solid Phase Microextraction / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D008674:Metals, Rare Earth; D011108:Polymers
keywords: Biological samples; Capillary microextraction; Inductively coupled plasma mass spectrometry; Polymer monolith; Rare earth elements