title: Non-peptidyl insulin mimetics as a potential antidiabetic agent.
abstract: Insulin has an important role in the maintenance of blood sugar. It is the only available therapeutic agent for the treatment of type 1 diabetes mellitus and there is a dire need for an oral substitute. Different categories of compounds including mono and di substituted benzoquinones, vanadium based compounds and natural products have been reported to cause insulin-like effects either by increasing phosphorylation of insulin receptor (IR) or inhibiting the protein tyrosine phosphatases. This review summarizes the development of various insulin mimetics with special emphasis on their structure-activity relationships and various biological actions they produce.
authors.affiliation: Bioengineering and Drug Design Lab, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India.
authors.forename: Rakesh P
authors.initials: RP
authors.lastname: Nankar
authors.forename: Mukesh
authors.initials: M
authors.lastname: Doble
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry / Q000627:therapeutic use*; D032701:Biomimetics / Q000379:methods*; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D007328:Insulin / Q000737:chemistry / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin