title: [Clinical significance of Helicobacter pylori in children with idiopathic thrombocytopenic purpura].
abstract: This study was aimed to investigate the clinic significance of helicobacter pylori (HP) in children with idiopathic thrombocytopenic purpura (ITP). The infection of HP in 92 ITP children was determined by (13) C-Urea Breath Test, the same test was also performed on 66 healthy children. The 68 children infected with HP were randomly divided into 2 groups: single drug group treated only with corticosteroid and; combined drug group treated with corticosteroid and anti-helicobacter pylori treatment. The results showed that 68 patients infected with HP were found in 92 ITP children (74.7%), 26 patients infected with HP were observed in 66 healthy children (39.4%), which was lower than that in ITP children (74.7%, P < 0.05). After anti-helicobacter pylori therapy, the total effective rate and cure rate of ITP patients increased respectively from 73.5% to 94.1%, and the total recurrence rate (17.0%) was much lower than single drug group (47.1%, P < 0.05). Otherwise, after therapy the platelet count in both two groups increased continuously, and at the same time point, the platelet count in anti-helicobacter pylori group was higher than that in the single drug group (P < 0.05). It is concluded that the ITP children have a higher infection rate of HP, which may be involved in the pathogenesis of ITP. Anti-helicobacter pylori therapy would help to improve the therapeutic efficacy and reduce the recurrence of ITP children.
authors.affiliation: Department of Hematology, Affiliated Hospital of Weifang Medical College, Weifang, Shandong Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tang
authors.forename: Shu-Chun
authors.initials: SC
authors.lastname: Wang
authors.forename: Lu-Juan
authors.initials: LJ
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Wang
authors.forename: Zhan-Ju
authors.initials: ZJ
authors.lastname: Wang
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001944:Breath Tests; D016022:Case-Control Studies; D002648:Child; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000382:microbiology*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones