title: Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine.
abstract: Despite the fact that advances of burn treatment have led to reduction in the morbidity caused by burns, burn infection is still a serious problem. In this study, we designed blended synthetic and natural polymers nanofiber scaffolds using polyurethane (PU) and gelatin, which were prepared by an electrospinning method. Silver-sulfadiazine (SSD) was co-mixed to the blended polymer solution for being incorporated into the nanofibers after the electrospinning, followed by examination of burn-wound healing effect. The nanofiber scaffolds containing SSD should not only serve as a substrate for skin regeneration, but may also deliver suitable drugs, within a controlled manner during healing. The SSD release was able to prevent the growth of a wide array of bacteria and accelerate the wound healing by preventing infection. Therefore it could accelerate the burn-wound closure rate. We confirmed that PU/gelatin nanofiber scaffolds containing SSD lead to enhanced regeneration of burn-wounds.
authors.affiliation: Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Seoul, 130-701, Republic of Korea.
authors.forename: Dong Nyoung
authors.initials: DN
authors.lastname: Heo
authors.forename: Dae Hyeok
authors.initials: DH
authors.lastname: Yang
authors.forename: Jung Bok
authors.initials: JB
authors.lastname: Lee
authors.forename: Min Soo
authors.initials: MS
authors.lastname: Bae
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Moon
authors.forename: Heoung Jae
authors.initials: HJ
authors.lastname: Chun
authors.forename: Chun Ho
authors.initials: CH
authors.lastname: Kim
authors.forename: Ho-Nam
authors.initials: HN
authors.lastname: Lim
authors.forename: Il Keun
authors.initials: IK
authors.lastname: Kwon
mesh_terms: D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D002417:Cattle; D005780:Gelatin / Q000737:chemistry*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D057139:Nanofibers / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012837:Silver Sulfadiazine / Q000494:pharmacology / Q000627:therapeutic use*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D011140:Polyurethanes; D005780:Gelatin; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D012837:Silver Sulfadiazine