title: The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis.
abstract: Necrotizing enterocolitis (NEC) is a devastating intestinal disease resulting in major neonatal morbidity and mortality. The pathology is poorly understood, and the means of preventing and treating NEC are limited. Several endogenous growth factors have been identified as having important roles in intestinal growth as well as aiding intestinal repair from injury or inflammation. In this review, we will discuss several growth factors as mediators of intestinal regeneration and repair as well as potential therapeutic agents for NEC.
authors.affiliation: Division of Pediatric Surgery, St Louis Children's Hospital, St Louis, One's Children's Place, Suite 5540, Missouri 63110, USA.
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Rowland
authors.forename: Pamela M
authors.initials: PM
authors.lastname: Choi
authors.forename: Brad W
authors.initials: BW
authors.lastname: Warner
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D020345:Enterocolitis, Necrotizing / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism* / Q000627:therapeutic use; D007413:Intestinal Mucosa / Q000378:metabolism / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*
chemical_list: D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins