title: Potential anti-inflammatory effect of low-level laser therapy on the experimental reflux laryngitis: a preliminary study.
abstract: The most common cause of laryngitis is the laryngopharyngeal reflux disease. The symptoms of laryngitis can be hoarseness, globus, chronic cough, voice fatigue, throat pain, and dysphagia. Low-level laser therapy (LLLT) is beneficial to reduce the pain and inflammatory response without side effects. Therefore, LLLT may be a useful tool for the treatment of laryngitis. This study proposes to analyze the effect of laser therapy in a model of reflux-induced laryngitis. The animals were randomly put into three groups: control--non-intubated; nasogastric intubation--intubated; and nasogastric intubation with laser therapy-intubated treated with 105-J/cm(2) laser irradiation. For the induction of laryngitis, the animals were anesthetized and a nasogastric tube was inserted through the nasopharynx until it reached the stomach, for 1 week. Thereafter, measurement of myeloperoxidase activity and the histopathological procedures were performed. In conclusion, we observed in this study that 105-J/cm(2) infrared laser reduced the influx of neutrophils in rats, and it improved the reparative collagenization of the laryngeal tissues.
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe (UFS), 49100-000, São Cristóvão, Sergipe, Brazil.
authors.forename: Renata R
authors.initials: RR
authors.lastname: Marinho
authors.forename: Renata M
authors.initials: RM
authors.lastname: Matos
authors.forename: Jandson S
authors.initials: JS
authors.lastname: Santos
authors.forename: Maria A G
authors.initials: MA
authors.lastname: Ribeiro
authors.forename: Ronaldo A
authors.initials: RA
authors.lastname: Ribeiro
authors.forename: Roberto C P
authors.initials: RC
authors.lastname: Lima
authors.forename: Ricardo L C
authors.initials: RL
authors.lastname: Albuquerque
authors.forename: Sara M
authors.initials: SM
authors.lastname: Thomazzi
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D024022:Fibrillar Collagens / Q000378:metabolism; D006801:Humans; D007441:Intubation, Gastrointestinal / Q000009:adverse effects; D007827:Laryngitis / Q000209:etiology* / Q000473:pathology / Q000532:radiotherapy*; D057045:Laryngopharyngeal Reflux / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D028022:Low-Level Light Therapy; D008297:Male; D009504:Neutrophils / Q000473:pathology; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D024022:Fibrillar Collagens; D009195:Peroxidase