title: Two new compounds from Schisandra glaucescens.
abstract: One new lignan (7S,8R,7'R,8'R)-7-(3,4-methylenedioxyphenyl)-8,8'-dimethyl-8'-hydroxyl-7'-methoxyl-7'-(3',4'-methylenedioxyphenyl)-tetrahydrofuran (1), one new sesquiterpene 2-hydroxy-11,12-dehydrocalamenene (2), one new natural product erythro-1-(3,4-dimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-2,3-dimethyl-butane (3), and two known lignans (+)-anwulignan(erythro-1-(4-hydroxy-3-methoxyphenyl)-4-(3,4-methylenedioxyphenyl)-2,3-dimethyl-butane) (4) and ( - )-zuonin-A (5) were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated by spectroscopic methods. The cytotoxicity of compounds 1 and 2 was assayed.
authors.affiliation: School of Pharmacy, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Zhang
authors.forename: Sha-Sha
authors.initials: SS
authors.lastname: Gao
authors.forename: Tian-Tian
authors.initials: TT
authors.lastname: Zhang
authors.forename: Xiao-Gang
authors.initials: XG
authors.lastname: Wang
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Qing
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Jiang
authors.forename: Jia-Chun
authors.initials: JC
authors.lastname: Chen
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Duan
authors.forename: Jin-Bo
authors.initials: JB
authors.lastname: Fang
mesh_terms: D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005663:Furans; D045325:HCT116 Cells; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: C582531:(7S,8R,7'R,8'R)-7-(3,4-methylenedioxyphenyl)-8,8'-dimethyl-8'-hydroxyl-7'-methoxyl-7'-(3',4'-methylenedioxyphenyl)tetrahydrofuran; C582530:2-hydroxy-11,12-dehydrocalamenene; D004365:Drugs, Chinese Herbal; D005663:Furans; D017705:Lignans; D012717:Sesquiterpenes; C018674:tetrahydrofuran