title: Global proteomic profiling and enrichment maps of dilated cardiomyopathy.
abstract: Global expression profiling is a promising technique to help uncover perturbations associated with heart disease. With the large amount of expression data generated, we demonstrate how a list of differentially expressed proteins or genes can be translated into a list of perturbed pathways and functions using conventional overrepresentation analysis such as gene set enrichment analysis, DAVID, and BiNGO. As outputs from ORA can be daunting in themselves, we further demonstrate how to visualize enrichment results as Enrichment Maps for easy interpretation and analysis.
authors.affiliation: The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
authors.forename: Ruth
authors.initials: R
authors.lastname: Isserlin
authors.forename: Daniele
authors.initials: D
authors.lastname: Merico
authors.forename: Andrew
authors.initials: A
authors.lastname: Emili
mesh_terms: D000465:Algorithms; D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D030562:Databases, Protein; D015870:Gene Expression; D020869:Gene Expression Profiling / Q000379:methods*; D055106:Genome-Wide Association Study; D006801:Humans; D005810:Multigene Family; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D025941:Protein Interaction Mapping; D020543:Proteome / Q000235:genetics* / Q000378:metabolism; D012984:Software
chemical_list: D020543:Proteome