title: Mechanical carbohydrate sensors based on soft hydrogel particles.
abstract: Elastic sensors: A simple method is presented for the measurement of specific biomolecular interactions with soft colloidal hydrogel particles (SCPs) as sensors. Carbohydrate/lectin interactions (see picture; green: carbohydrate molecules) were studied by optical detection of the mechanical deformation of the particles on a lectin surface. The affinity of various carbohydrate inhibitors could also be readily determined.
authors.affiliation: MPI für Kolloid und Grenzflächenforschung, Am Mühlenberg 1, 14424 Potsdam, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pussak
authors.forename: Daniela
authors.initials: D
authors.lastname: Ponader
authors.forename: Simone
authors.initials: S
authors.lastname: Mosca
authors.forename: Salomé Vargas
authors.initials: SV
authors.lastname: Ruiz
authors.forename: Laura
authors.initials: L
authors.lastname: Hartmann
authors.forename: Stephan
authors.initials: S
authors.lastname: Schmidt
mesh_terms: D015374:Biosensing Techniques; D002241:Carbohydrates / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry; D008857:Microscopy, Interference / Q000379:methods*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D011108:Polymers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate