title: Pharmacokinetics of hederacoside C, an active ingredient in AG NPP709, in rats.
abstract: 1. Hederacoside C (HDC) is one of the active ingredients in Hedera helix leaf extract (Ivy Ex.) and AG NPP709, a new botanical drug to treat acute respiratory infection and chronic inflammatory bronchitis. However, information regarding its pharmacokinetic properties remains limited. 2. Here, we report the pharmacokinetics of HDC in rats after intravenous administration of HDC (3, 12.5, and 25 mg/kg) and after oral administration of HDC, Ivy Ex., and AG NPP709 (equivalent to 12.5, 25, and 50 mg/kg HDC). 3. Linear pharmacokinetics of HDC were identified upon its intravenous administration at doses of 3-25 mg/kg. Intravenous administration of HDC results in relatively slow clearance (1.46-2.08 mL/min/kg) and a small volume of distribution at steady state (138-222 mL/kg), while oral administration results in a low absolute oral bioavailability (F) of 0.118-0.250%. The extremely low F of HDC may be due to poor absorption of HDC from the gastrointestinal (GI) tract and/or its decomposition therein. 4. The oral pharmacokinetics of HDC did not differ significantly among pure HDC, Ivy Ex., and AG NPP709.
authors.affiliation: College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea , Bucheon , South Korea .
authors.forename: Ju Myung
authors.initials: JM
authors.lastname: Kim
authors.forename: Ji Na
authors.initials: JN
authors.lastname: Yoon
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Jung
authors.forename: Hye Duck
authors.initials: HD
authors.lastname: Choi
authors.forename: Young June
authors.initials: YJ
authors.lastname: Shin
authors.forename: Chang Kyun
authors.initials: CK
authors.lastname: Han
authors.forename: Hye Suk
authors.initials: HS
authors.lastname: Lee
authors.forename: Hee Eun
authors.initials: HE
authors.lastname: Kang
mesh_terms: D061605:Administration, Intravenous; D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D008297:Male; D009828:Oleanolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics; D010936:Plant Extracts / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D011485:Protein Binding; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: C000588959:AG NPP709; D010936:Plant Extracts; C482302:hederacoside C; D009828:Oleanolic Acid