title: Self-adjuvanting synthetic antitumor vaccines from MUC1 glycopeptides conjugated to T-cell epitopes from tetanus toxoid.
abstract: The T-helper epitope peptide P30 (green in the scheme) from tetanus toxoid was used as the immunostimulant in MUC1 glycopeptide antitumor vaccines and apparently also acts as a built-in adjuvant. P30-conjugated glycopeptide vaccines containing three glycans in the immunodominant motifs PDTRP and GSTAP induced much stronger immune responses and complement dependent cytotoxicity mediated killing of tumor cells when applied in plain PBS solution without complete Freund's adjuvant.
authors.affiliation: Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Cai
authors.forename: Mei-Sha
authors.initials: MS
authors.lastname: Chen
authors.forename: Zhan-Yi
authors.initials: ZY
authors.lastname: Sun
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Zhao
authors.forename: Horst
authors.initials: H
authors.lastname: Kunz
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: Li
mesh_terms: D019496:Cancer Vaccines / Q000737:chemistry*; D000939:Epitopes / Q000276:immunology*; D018985:Epitopes, B-Lymphocyte / Q000276:immunology; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D006020:Glycopeptides; D006801:Humans; D018396:Mucin-1 / Q000737:chemistry* / Q000276:immunology; D010455:Peptides; D013745:Tetanus Toxoid / Q000276:immunology*
chemical_list: D019496:Cancer Vaccines; D000939:Epitopes; D018985:Epitopes, B-Lymphocyte; D018984:Epitopes, T-Lymphocyte; D006020:Glycopeptides; D018396:Mucin-1; D010455:Peptides; D013745:Tetanus Toxoid