title: Subgrouping of gliomas on the basis of genetic profiles.
abstract: Management of gliomas depends on histological diagnosis; there are, however, limitations to the systems presently used. Tumors in the same entity can have different clinical courses, especially when they are diagnosed as WHO grade II-III. Previous studies revealed that genetic subgrouping of gliomas provides useful information that could help establishment of treatment procedures on the basis of the genetic background of the tumors. Recently, the authors analyzed the chromosomal copy number aberrations (CNAs) of adult supratentorial gliomas by comparative genomic hybridization using microdissected tissue sections. The tumors were classified into subgroups according to chromosomal CNAs. WHO grade II-III gliomas contained a variety of genetic subgroups that correlated well with the clinical course. Of these, long progression-free survival was observed for tumors with +7q and those with -1p/19q, low-grade tumors of 2 major lineages, and, in our preliminary data, both were closely correlated with mutation of IDH1. Furthermore, in contrast with +7q tumors, the great majority of +7 or +7/-10q groups had wildtype IDH1. Genetic studies suggest that cytogenetic characterization may provide an additional classification system for gliomas, and new criteria could help to establish rational and objective means for analysis of treatment procedures.
authors.affiliation: Department of Neurosurgery, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan, yhirose@fujita-hu.ac.jp.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hirose
authors.forename: Hikaru
authors.initials: H
authors.lastname: Sasaki
authors.forename: Masato
authors.initials: M
authors.lastname: Abe
authors.forename: Natsuki
authors.initials: N
authors.lastname: Hattori
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Adachi
authors.forename: Yuya
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Shinya
authors.initials: S
authors.lastname: Nagahisa
authors.forename: Takuro
authors.initials: T
authors.lastname: Hayashi
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Kazunari
authors.initials: K
authors.lastname: Yoshida
mesh_terms: D001254:Astrocytoma; D002869:Chromosome Aberrations; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D056915:DNA Copy Number Variations / Q000235:genetics; D005910:Glioma / Q000145:classification* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D009154:Mutation; D009367:Neoplasm Staging; D015173:Supratentorial Neoplasms / Q000145:classification* / Q000235:genetics* / Q000473:pathology
chemical_list: D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human