title: In vivo MRI cell tracking using perfluorocarbon probes and fluorine-19 detection.
abstract: This article presents a brief review of preclinical in vivo cell-tracking methods and applications using perfluorocarbon (PFC) probes and fluorine-19 ((19) F) MRI detection. Detection of the (19) F signal offers high cell specificity and quantification ability in spin density-weighted MR images. We discuss the compositions of matter, methods and applications of PFC-based cell tracking using ex vivo and in situ PFC labeling in preclinical studies of inflammation and cellular therapeutics. We also address the potential applicability of (19) F cell tracking to clinical trials.
authors.affiliation: Department of Biological Sciences and Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA 15213, USA. eta@cmu.edu
authors.forename: Eric T
authors.initials: ET
authors.lastname: Ahrens
authors.forename: Jia
authors.initials: J
authors.lastname: Zhong
mesh_terms: D000818:Animals; D058948:Cell Tracking / Q000379:methods*; D003287:Contrast Media; D005461:Fluorine; D005466:Fluorocarbons; D006801:Humans; D008279:Magnetic Resonance Imaging; D015335:Molecular Probes
chemical_list: D003287:Contrast Media; D005466:Fluorocarbons; D015335:Molecular Probes; D005461:Fluorine