title: Synthesis of 2-aminophenols and heterocycles by Ru-catalyzed C-H mono- and dihydroxylation.
abstract: A novel and efficient synthesis of 2-aminophenols, 2-aminobenzene-1,3-diols, and heterocycles through Ru-catalyzed C-H mono- and dihydroxylation of anilides has been developed with a new directing group strategy. The reaction demonstrates excellent reactivity, regioselectivity, good functional group tolerance, and high yields.
authors.affiliation: MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University , Beijing 100084, China.
authors.forename: Xinglin
authors.initials: X
authors.lastname: Yang
authors.forename: Gang
authors.initials: G
authors.lastname: Shan
authors.forename: Yu
authors.initials: Y
authors.lastname: Rao
mesh_terms: D000627:Aminophenols / Q000138:chemical synthesis* / Q000737:chemistry; D000813:Anilides / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006900:Hydroxylation; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000627:Aminophenols; D000813:Anilides; D006571:Heterocyclic Compounds; C027667:2-aminophenol; D012428:Ruthenium