title: Association of promoter region polymorphisms of CD209 gene with clinical outcomes of dengue virus infection in Western India.
abstract: Dendritic cell specific intercellular adhesion molecule 3 grabbing non-integrin, coded by the CD209 gene, acts as an entry receptor for dengue virus. Polymorphisms in the promoter region of CD209 gene (rs735239, rs4804803, rs2287886) were investigated in 112 hospitalized cases of dengue (DEN) and 104 healthy controls to find out whether they are associated with dengue in a Western Indian population. Results revealed a significantly higher frequency of 'G' allele and 'G/G' genotype of rs2287886 and A-A-G haplotype of CD209 gene in DEN compared to healthy controls [For 'G/G' genotype, P=0.0072, Odds ratio (OR) 2.43; For A-A-G haplotype, P=0.0033, OR 2]. The frequency of A/A genotype of rs735239 was higher in DEN cases with thrombocytopenia compared to cases without thrombocytopenia (P=0.026). The results suggest that rs2287886 G/G genotype of CD209 gene is associated with development of dengue requiring hospitalization while A/A genotype of rs735239 is associated with thrombocytopenia in dengue cases.
authors.affiliation: Dengue Group, National Institute of Virology, 20A, Dr Ambedkar Road, Pune 411001, Maharashtra, India. alagarasu@gmail.com
authors.forename: Kalichamy
authors.initials: K
authors.lastname: Alagarasu
authors.forename: Indraneel M
authors.initials: IM
authors.lastname: Damle
authors.forename: Rupali V
authors.initials: RV
authors.lastname: Bachal
authors.forename: Aditya P
authors.initials: AP
authors.lastname: Mulay
authors.forename: Paresh S
authors.initials: PS
authors.lastname: Shah
authors.forename: Cecilia
authors.initials: C
authors.lastname: Dayaraj
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000235:genetics*; D003715:Dengue / Q000150:complications / Q000235:genetics*; D003716:Dengue Virus; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007194:India; D037181:Lectins, C-Type / Q000235:genetics*; D063868:Patient Outcome Assessment; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011956:Receptors, Cell Surface / Q000235:genetics*; D013921:Thrombocytopenia / Q000209:etiology; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin