title: Vacuolar myopathy in an adult Warmblood horse.
abstract: Histopathological interpretation of semimembranosus muscle samples from an adult Warmblood mare with clinical signs suggestive of exertional rhabdomyolysis and intermittent mild elevations in muscle enzyme activities revealed abundant sarcoplasmic vacuoles in all fibre-types containing fine, apparently proteinaceous debris. Vacuolar contents stained lightly with PAS, but did not appear to contain amylopectate, lipid or acid phosphatase and their periphery was unstained with dystrophin immunohistochemistry. Electron microscopy revealed that vacuoles were not membrane bound. No vacuoles were detected in muscle samples evaluated at post mortem following 4 months of rest. To our knowledge, this is the first report of a presumed primary vacuolar myopathy in a horse.
authors.affiliation: Comparative Neuromuscular Diseases Laboratory, Royal Veterinary College, Royal College Street, London NW1 0TU, UK. cmassey@rvc.ac.uk
authors.forename: C A
authors.initials: CA
authors.lastname: Massey
authors.forename: G L
authors.initials: GL
authors.lastname: Walmsley
authors.forename: T P
authors.initials: TP
authors.lastname: Gliddon
authors.forename: R J
authors.initials: RJ
authors.lastname: Piercy
mesh_terms: D000375:Aging; D000818:Animals; D016189:Dystrophin / Q000378:metabolism; D005260:Female; D006734:Horse Diseases / Q000378:metabolism / Q000473:pathology*; D006736:Horses; D007150:Immunohistochemistry; D016464:Lysosomal Storage Diseases / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D008854:Microscopy, Electron / Q000379:methods; D009135:Muscular Diseases / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
chemical_list: D016189:Dystrophin