title: Human dendritic cell subsets.
abstract: Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets of DCs have intrinsic differences that lead to functional specialisation in the generation of immunity. Comparative studies are now allowing many of these properties to be more fully understood in the context of human immunology.
authors.affiliation: Human Dendritic Cell Laboratory, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. matthew.collin@ncl.ac.uk
authors.forename: Matthew
authors.initials: M
authors.lastname: Collin
authors.forename: Naomi
authors.initials: N
authors.lastname: McGovern
authors.forename: Muzlifah
authors.initials: M
authors.lastname: Haniffa
mesh_terms: D018949:Antigens, CD1 / Q000378:metabolism; D019070:Cell Lineage / Q000276:immunology; D003713:Dendritic Cells / Q000145:classification* / Q000166:cytology / Q000276:immunology*; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D007801:Langerhans Cells / Q000145:classification / Q000276:immunology; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D017628:Microglia / Q000145:classification / Q000276:immunology; D009000:Monocytes / Q000276:immunology
chemical_list: D018949:Antigens, CD1; C437944:CD1C protein, human; D006023:Glycoproteins; D018950:Lipopolysaccharide Receptors
keywords: dendritic cells; haematology; therapy/immunotherapy