title: Photodynamic therapy in the treatment of basal cell carcinoma.
abstract: Photodynamic therapy (PDT) is a medical procedure based on the activation of the molecules of various exogenous or endogenous chemical substances called photosensitizers by a light source emitting radiation of an adequate wavelength, usually situated in the visible spectrum; photosensitizers are chemical compounds bearing the capacity to selectively concentrate in the neoplastic cells. The energy captured by the molecules of these substances pervaded in the tumor cells is subsequently discharged in the surrounding tissue, triggering certain photodynamic reactions that result in the destruction of the tumor. The procedure is applicable in numerous medical fields. Skin basal cell carcinoma (BCC), the most frequent type of cancer of the human species, is a cutaneous tumor that responds very well to this innovative treatment method. By reviewing numerous recent studies in the field, this article aims to present the role and the indications of photodynamic therapy in the management of basal cell carcinoma, as well as the most important results achieved so far by this therapy in the field of dermato-oncology.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Department of Oncologic Dermatology and Allergology, "Elias" University Emergency Hospital, Bucharest. matei_clara@yahoo.com
authors.forename: C
authors.initials: C
authors.lastname: Matei
authors.forename: M
authors.initials: M
authors.lastname: Tampa
authors.forename: T
authors.initials: T
authors.lastname: Poteca
authors.forename: G
authors.initials: G
authors.lastname: Panea-Paunica
authors.forename: S R
authors.initials: SR
authors.lastname: Georgescu
authors.forename: R M
authors.initials: RM
authors.lastname: Ion
authors.forename: S M
authors.initials: SM
authors.lastname: Popescu
authors.forename: C
authors.initials: C
authors.lastname: Giurcaneanu
mesh_terms: D000622:Aminolevulinic Acid / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D006801:Humans; D010778:Photochemotherapy; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D000622:Aminolevulinic Acid
keywords: Photodynamic therapy; aminolevulinic acid; basal cell carcinoma; methyl aminolevulinate