title: Are central line bundles and ventilator bundles effective in critically ill neonates and children?
abstract: Central line-associated bloodstream infections (CLABSI) and ventilator-associated pneumonia (VAP) are common problems in adult, pediatric (PICU) and neonatal (NICU) intensive care unit patients. Care bundles have been developed to prevent these hospital-acquired infections and to provide best possible care. Studies in adults have proven that care bundles contribute to a decrease in CLABSI and VAP rates. The purpose of this literature review was to critically appraise the known evidence of the effectiveness of central line bundles and ventilator bundles in PICU and NICU patients. The number of publications of central line bundles and ventilator bundles in PICU and NICU patients is limited compared to adults. Ten studies in PICU patients demonstrated a significant decrease in the CLABSI or VAP rate after implementation of the bundle. Two studies in neonates demonstrated a reduction in the CLABSI rate after implementation of the central line bundle. No studies on the effectiveness of the ventilator bundle in neonates were found. Bundle elements differed between studies, and their scientific basis was not as robust as in adults. Monitoring of compliance to bundle elements seems required for optimal reduction of CLABSI and VAP. Bundle components that focus on maintenance of a central line probably are important to prevent CLABSI in children.
authors.affiliation: Utrecht University, Utrecht, The Netherlands.
authors.forename: Charlotte A
authors.initials: CA
authors.lastname: Smulders
authors.forename: Josephus P J
authors.initials: JP
authors.lastname: van Gestel
authors.forename: Albert P
authors.initials: AP
authors.lastname: Bos
mesh_terms: D055499:Catheter-Related Infections / Q000209:etiology / Q000517:prevention & control; D062905:Central Venous Catheters / Q000009:adverse effects*; D002648:Child; D002985:Clinical Protocols; D016638:Critical Illness; D003428:Cross Infection / Q000517:prevention & control*; D019317:Evidence-Based Medicine; D006801:Humans; D007231:Infant, Newborn; D053717:Pneumonia, Ventilator-Associated / Q000209:etiology / Q000517:prevention & control; D012122:Ventilators, Mechanical / Q000009:adverse effects*