title: Neural, psychophysiological, and behavioral markers of fear processing in PTSD: a review of the literature.
abstract: As presently defined, post-traumatic stress disorder (PTSD) is an amalgam of symptoms falling into: re-experiencing of the trauma, avoidance of reminders of it, emotional numbing and hyperarousal. PTSD has a well-known proximate cause, commonly occurring after a life-threatening event that induces a response of intense fear, horror, and helplessness. Much of the advancement in understanding of the neurobiology of PTSD has emerged from conceptualizing the disorder as one that involves substantial dysfunction in fear processing. This article reviews recent knowledge of fear processing markers in PTSD. A systematic search was performed of reports within the specific three-year publication time period of January 2010 to December 2012. We identified a total of 31 studies reporting fear processing markers in PTSD. We further categorized them according to the following classification: (1) neural-activation markers (n=10), (2) psychophysiological markers (n=14), and (3) behavioral markers (n=7). Across most studies reviewed here, significant differences between individuals with PTSD and healthy controls were shown. Methodological, theoretical and clinical implications were discussed.
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, Unit # 69, New York, NY 10032, USA. es2297@columbia.edu
authors.forename: Erel
authors.initials: E
authors.lastname: Shvil
authors.forename: Heather L
authors.initials: HL
authors.lastname: Rusch
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Sullivan
authors.forename: Yuval
authors.initials: Y
authors.lastname: Neria
mesh_terms: D001362:Avoidance Learning / Q000502:physiology; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000502:physiology; D005239:Fear / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D059906:Neuroimaging / Q000379:methods; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology* / Q000523:psychology
chemical_list: D015415:Biomarkers