title: High burden of metastases and poor outcome in pelvic PNET.
abstract: Data on prognostic factors in pelvic PNET are minimal. We analyzed patients with pelvic PNET treated between June 2003 and November 2011 for prognostic factors. Forty-eight (13%) of 374 patients with PNET were pelvic PNET with median age 14.5 years (range: 5-33); 31 (65%) had metastases. After median follow-up of 20.4 months (range: 1.3-64.9), 3-year EFS, OS, and local-control-rate were 13.5 ± 5.5%, 15.4 ± 9%, and 41.3 ± 14.9%, respectively. Hypoalbuminemia (≤3.4 g/dl) predicted inferior EFS and OS for both entire cohort and metastatic group. All patients with hypoalbuminemia (n = 10) had low BMI as compared to 23/38 without hypoalbuminemia (P = 0.02).
authors.affiliation: Department of Medical Oncology, Dr. B R A Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Bivas
authors.initials: B
authors.lastname: Biswas
authors.forename: Sandeep
authors.initials: S
authors.lastname: Agarwala
authors.forename: Shishir
authors.initials: S
authors.lastname: Rastogi
authors.forename: Shah Alam
authors.initials: SA
authors.lastname: Khan
authors.forename: B K
authors.initials: BK
authors.lastname: Mohanti
authors.forename: D N
authors.initials: DN
authors.lastname: Sharma
authors.forename: Sushmita
authors.initials: S
authors.lastname: Pathy
authors.forename: Sameer
authors.initials: S
authors.lastname: Bakhshi
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D034141:Hypoalbuminemia / Q000097:blood / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D007223:Infant; D008297:Male; D009362:Neoplasm Metastasis; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000097:blood / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D010386:Pelvic Neoplasms / Q000097:blood / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D015996:Survival Rate
keywords: chemotherapy; outcome; pelvic EWING's sarcoma; prognostic factors; radical radiotherapy