title: Hyperuricemia is an independent risk factor for mortality only if chronic kidney disease is present.
abstract: OBJECTIVE
  Hyperuricemia has been considered a risk factor for renal disease and cardiovascular disease. However, the potential contribution of hyperuricemia to mortality remains uncertain, and the results in the available literature vary according to kidney function. The aim of this study was to determine the association between hyperuricemia and mortality in patients undergoing percutaneous coronary intervention (PCI) across the interaction of kidney function.
  
  
  METHODS
  We retrospectively reviewed patients who underwent PCI from 2003 to 2009. Propensity scores for hyperuricemia (>7 mg/dl for males and >6 mg/dl for females) were used to assemble a matched cohort of 693 pairs of patients with and without hyperuricemia for analysis from the 3,201 patients who fulfilled the inclusion criteria among the 4,842 patients who underwent PCI.
  
  
  RESULTS
  Of the 3,201 patients who underwent PCI and for whom data were available regarding their baseline serum uric acid level, 763 (23.8%) had hyperuricemia. The hyperuricemia-associated hazard ratios (HRs) [95% confidence intervals (CIs)] for all-cause mortality were 1.780 (1.270-2.495) in the unmatched cohort and 1.655 (1.109-2.468) in the matched cohort. The HRs (95% CI) for all-cause mortality among those with and without chronic kidney disease (CKD) were 2.080 (1.318-3.283) and 1.592 (0.778-3.256), respectively (p for interaction, 0.001).
  
  
  CONCLUSIONS
  Hyperuricemia is an independent risk factor for all-cause mortality in those patients with CKD but not in those without CKD.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Gachon University of Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.
authors.forename: Wookyung
authors.initials: W
authors.lastname: Chung
authors.forename: Ae Jin
authors.initials: AJ
authors.lastname: Kim
authors.forename: Han
authors.initials: H
authors.lastname: Ro
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Chang
authors.forename: Hyun Hee
authors.initials: HH
authors.lastname: Lee
authors.forename: Ji Yong
authors.initials: JY
authors.lastname: Jung
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000401:mortality*; D051436:Renal Insufficiency, Chronic / Q000401:mortality*; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies