title: Visualization of thermal ablation lesions using cumulative dynamic contrast enhancement MRI.
abstract: A novel robust and user friendly method for post-processing dynamic contrast enhanced (DCE) MRI data is presented, which provides reliable real-time delineation of the borders of thermal ablation lesions on low SNR images shortly after contrast agent injection without any model-based curve fitting. Some simple descriptors of the DCE process are calculated in a time efficient recursive manner and combined into a single image reflecting both current and previous enhancement states of each pixel, which allows robust discrimination between tissue areas with different perfusion properties. The resulting cumulative DCE (CDCE) images are shown to exhibit a strong correlation with histopathology and late gadolinium enhancement representations of the thermal damage in soft tissue. It is shown that the outer border of the non-perfused ablation lesion core on CDCE MRI corresponds to the histopathological lesion border. The described method has a potential not only to facilitate thermal ablation outcome assessment, but also to improve detection of infiltrative tumours and reduce the administered contrast agent dose in any DCE scans.
authors.affiliation: Cardiac and Interventional Applied Science Laboratory, General Electric Healthcare, Toronto, Ontario, Canada. andriy.shmatukha@swri.ca
authors.forename: Andriy
authors.initials: A
authors.lastname: Shmatukha
authors.forename: Benu
authors.initials: B
authors.lastname: Sethi
authors.forename: Mohammed
authors.initials: M
authors.lastname: Shurrab
authors.forename: Sudip
authors.initials: S
authors.lastname: Ghate
authors.forename: Xiuling
authors.initials: X
authors.lastname: Qi
authors.forename: Jennifer
authors.initials: J
authors.lastname: Barry
authors.forename: Graham
authors.initials: G
authors.lastname: Wright
authors.forename: Eugene
authors.initials: E
authors.lastname: Crystal
mesh_terms: D055011:Ablation Techniques; D000818:Animals; D003287:Contrast Media; D005682:Gadolinium; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011817:Rabbits; D013696:Temperature
chemical_list: D003287:Contrast Media; D005682:Gadolinium