title: Case report: imaging features in a renal transplant patient with calcineurin inhibitor-induced pain syndrome (CIPS).
abstract: Post-transplant distal limb bone marrow edema syndrome or calcineurin inhibitor-induced pain syndrome (CIPS) is generally a self-limiting but debilitating acute pain syndrome that has been reported in 2-14 % of renal transplant recipients. The disease is extensively described in the transplant literature in patients receiving the calcineurin inhibitors cyclosporine and tacrolimus. We present a case of CIPS arising in a patient 73 days after renal allograft, review the imaging findings, and discuss proposed etiologies and differential diagnoses. To the authors' knowledge, CIPS has not been characterized as a distinct entity in the radiology literature.
authors.affiliation: Department of Radiology and Radiological Science, Medical University of South Carolina, 96 Jonathan Lucas Street, MSC 323, Charleston, SC 29425, USA. chapinrw@musc.edu
authors.forename: Russell W
authors.initials: RW
authors.lastname: Chapin
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Chua
authors.forename: Jennifer
authors.initials: J
authors.lastname: Simmons
authors.forename: Martin
authors.initials: M
authors.lastname: Bunke
mesh_terms: D000328:Adult; D018771:Arthralgia / Q000139:chemically induced* / Q000175:diagnosis*; D065095:Calcineurin Inhibitors; D003937:Diagnosis, Differential; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D064847:Multimodal Imaging; D011292:Premedication / Q000009:adverse effects*; D013577:Syndrome; D016559:Tacrolimus / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D016559:Tacrolimus