title: Virulence aspects of Listeria monocytogenes LO28 high pressure-resistant variants.
abstract: High pressure treatment is a novel food processing approach for reducing pathogens in foods and food ingredients. However, relatively little is known about the pathogenic potential of organisms that survive the treatment. Twelve previously isolated and characterized variants of Listeria monocytogenes LO28 obtained after a high pressure treatment were assessed for their virulence potential and antibiotic susceptibility. Ten variants showed attenuated virulence while two variants retained full virulence in a mouse model of infection. Seven of the attenuated variants demonstrated a reduction in virulence factor activity. Compared to the wild type, all variants exhibited similar or increased susceptibility to multiple antibiotics commonly used in listeriosis treatment.
authors.affiliation: Top Institute Food and Nutrition (TIFN), P.O. Box 557, 6700 AN Wageningen, The Netherlands.
authors.forename: Ineke K H
authors.initials: IK
authors.lastname: Van Boeijen
authors.forename: Pat G
authors.initials: PG
authors.lastname: Casey
authors.forename: Colin
authors.initials: C
authors.lastname: Hill
authors.forename: Roy
authors.initials: R
authors.lastname: Moezelaar
authors.forename: Marcel H
authors.initials: MH
authors.lastname: Zwietering
authors.forename: Cormac G M
authors.initials: CG
authors.lastname: Gahan
authors.forename: Tjakko
authors.initials: T
authors.lastname: Abee
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D006874:Hydrostatic Pressure; D008089:Listeria monocytogenes / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology; D008088:Listeriosis / Q000382:microbiology / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability; D014774:Virulence; D037521:Virulence Factors / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D037521:Virulence Factors