title: A comparative study of bone formation following grafting with different ratios of particle dentin and tricalcium phosphate combinations.
abstract: This study aimed to evaluate the bone regeneration relative to tooth powder and tricalcium phosphate (TCP) mixing ratios using the rabbit cranium defect model. The tooth powder was mixed with TCP in 1:1, 3:1, and 1:3 ratios, and the different ratios were implanted in the rabbit cranium defect for 4 and 8 weeks. Powders crystal structure evaluated using scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and new bone formation (NBF) was analyzed using micro-computed tomography (CT) and histologic examination. NBF in the control group was restricted to the defect margins. More NBF was observed around the defect margins in the experimental groups compared with the control group. Specifically, active NBF was identified around the implant materials of the centrifugal part of the defect and defect margins in the 3:1 tooth powder: TCP group. Our results suggested that tooth powder and TCP may be useful in bone regeneration.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, Gwangju, 501-759, Republic of Korea.
authors.forename: Seung-Chan
authors.initials: SC
authors.lastname: Jin
authors.forename: Su-Gwan
authors.initials: SG
authors.lastname: Kim
authors.forename: Ji-Su
authors.initials: JS
authors.lastname: Oh
authors.forename: Sook-Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Eun-Sook
authors.initials: ES
authors.lastname: Jang
authors.forename: Zheng-Gang
authors.initials: ZG
authors.lastname: Piao
authors.forename: Sung-Chul
authors.initials: SC
authors.lastname: Lim
authors.forename: Mi-Ae
authors.initials: MA
authors.lastname: Jeong
authors.forename: Jae-Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Jae-Seek
authors.initials: JS
authors.lastname: You
authors.forename: Seung-Cheol
authors.initials: SC
authors.lastname: Park
authors.forename: Young-Seung
authors.initials: YS
authors.lastname: Cho
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Yang
authors.forename: Sun-Kyung
authors.initials: SK
authors.lastname: Yu
mesh_terms: D000818:Animals; D002130:Calcium Phosphates / Q000494:pharmacology*; D003804:Dentin / Q000737:chemistry*; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects*; D010316:Particle Size; D011817:Rabbits; D012886:Skull / Q000000981:diagnostic imaging / Q000187:drug effects / Q000254:growth & development / Q000473:pathology; D017550:Spectroscopy, Fourier Transform Infrared; D055114:X-Ray Microtomography
chemical_list: D002130:Calcium Phosphates; C018392:tricalcium phosphate