title: Fatty acid binding protein 4 predicts left ventricular mass and longitudinal function in overweight and obese women.
abstract: OBJECTIVE
  To explore whether increased adipocyte-derived serum fatty acid binding protein 4 (FABP4) predisposes to cardiac remodelling and left ventricular dysfunction in human obesity.
  
  
  METHODS
  Cross-sectional investigation.
  
  
  METHODS
  Academic clinical research centre.
  
  
  METHODS
  108 overweight and obese non-diabetic women (body-mass index 33 ± 5 kg/m2).
  
  
  METHODS
  None.
  
  
  METHODS
  Relationship between serum FABP4 and abdominal adipose tissue quantified by MRI. Relationship between serum FABP4 and left ventricular morphology and function assessed by cardiac MRI.
  
  
  RESULTS
  FABP4 was independently associated with visceral abdominal adipose tissue (β=0.34, p<0.01) and subcutaneous abdominal adipose tissue (β=0.22, p<0.05). After stratification into serum FABP4 tertiles, left ventricular masses were 92 ± 16 g, 86 ± 13 g and 81 ± 12 g in women with high, intermediate and low FABP4 concentrations (p<0.01), respectively. Longitudinal systolic function was reduced by 8% in women with intermediate and high versus low FABP4 concentrations (p<0.01), whereas ejection fraction did not differ among tertiles (p=0.5). In multivariate linear analysis FABP4 remained an independent predictor of left ventricular mass (β=0.17, p<0.05) and reduced longitudinal fractional shortening (β=0.21, p<0.05).
  
  
  CONCLUSIONS
  In overweight and obese women, FABP4 showed an independent association with parameters of left ventricular remodelling.
authors.affiliation: Institute of Clinical Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany. engeli.stefan@mh-hannover.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Engeli
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Utz
authors.forename: Sven
authors.initials: S
authors.lastname: Haufe
authors.forename: Valéria
authors.initials: V
authors.lastname: Lamounier-Zepter
authors.forename: Martin
authors.initials: M
authors.lastname: Pofahl
authors.forename: Julius
authors.initials: J
authors.lastname: Traber
authors.forename: Jürgen
authors.initials: J
authors.lastname: Janke
authors.forename: Friedrich C
authors.initials: FC
authors.lastname: Luft
authors.forename: Michael
authors.initials: M
authors.lastname: Boschmann
authors.forename: Jeanette
authors.initials: J
authors.lastname: Schulz-Menger
authors.forename: Jens
authors.initials: J
authors.lastname: Jordan
mesh_terms: D050154:Adiposity; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005858:Germany; D006801:Humans; D050152:Intra-Abdominal Fat / Q000473:pathology; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000178:diet therapy / Q000473:pathology; D050177:Overweight / Q000097:blood / Q000150:complications* / Q000178:diet therapy / Q000473:pathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013318:Stroke Volume; D050151:Subcutaneous Fat / Q000473:pathology; D013599:Systole; D015854:Up-Regulation; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
chemical_list: D015415:Biomarkers; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins