title: Weight reduction is associated with increased plasma fibrin clot lysis.
abstract: Obesity is associated with an increased risk of vascular thrombotic events. We sought to investigate how obesity and weight loss affect plasma fibrin clot properties. A total of 29 obese patients were studied before and after 3-month low-fat diet. Plasma fibrin clot parameters, including fibrin clot permeation coefficient (Ks), the lag phase of the turbidity curve, clot lysis time (t 50%), maximum rate of increase in D-dimer levels, and maximum D-dimer concentrations, were determined. Low-fat diet resulted in the reduction of body weight (P < .0001), body mass index (P < .0001), fat mass (P < .0001), total cholesterol (P < .0001), low-density lipoprotein cholesterol (P = .0005), triglycerides (P = .008), and plasminogen activator inhibitor 1 (P = .02), but not in fibrinogen or C-reactive protein. The only change in fibrin clot variables was shorter t 50% (P = .02). Baseline t 50%, but not posttreatment, correlated with waist circumference (r = .44, p = .02). This study demonstrates that weight loss in obese people can increase the efficiency of fibrin clot lysis.
authors.affiliation: Józef Dietl Małopolska Higher School, Kraków, Poland beatabkol@mp.pl.
authors.forename: Beata
authors.initials: B
authors.lastname: Brzezińska-Kolarz
authors.affiliation: Avitum Poland, Hemodialysis Unit in Miechów, Miechów, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Kolarz
authors.affiliation: Obesity Treatment Centre, Kraków, Poland.
authors.forename: Angelika
authors.initials: A
authors.lastname: Wałach
authors.affiliation: Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland The John Paul II Hospital, Krakow, Poland.
authors.forename: Anetta
authors.initials: A
authors.lastname: Undas
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005342:Fibrinolysis; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D015431:Weight Loss
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D008055:Lipids; D017395:Plasminogen Activator Inhibitor 1; C036309:fibrin fragment D
keywords: hemostasis; thrombosis; vascular disease