title: Atypical forearm fractures associated with long-term use of bisphosphonate.
abstract: Recent reports on atypical femoral fracture have raised concerns about the long-term use of bisphosphonate. More recent case series focus specifically on the subtrochanteric fractures. But, there is relatively rarity and unawareness of atypical fracture in upper extremity. We report forearm fracture in two women receiving long-term bisphosphonate therapy. First woman presented with pain in the forearm and both thighs and radiographs showed incomplete fractures in a proximal ulnar shaft and bilateral femoral shaft. The other woman had a fracture in the radial shaft. This report suggests atypical fractures associated long-term use of bisphosphonate could occur in bones other than femur. More study is required to identify the magnitude of clinical features of this emerging concern.
authors.affiliation: Department of Orthopaedic Surgery, Korea University Guro Hospital, 97 Gurodong-gil, Guro-gu, Seoul 152-703, Korea. moonjg@korea.ac.kr
authors.forename: Jungyu
authors.initials: J
authors.lastname: Moon
authors.forename: Nitin
authors.initials: N
authors.lastname: Bither
authors.forename: Taehun
authors.initials: T
authors.lastname: Lee
mesh_terms: D000368:Aged; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D005264:Femoral Fractures / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D005593:Fracture Fixation, Internal / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D011859:Radiography; D011885:Radius Fractures / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D013997:Time Factors; D014458:Ulna Fractures / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates