title: Dutch resolution of racemates and the roles of solid solution formation and nucleation inhibition.
abstract: An overview is given of the principles of Pasteur resolutions via separation of diastereomeric salts.Thereafter, primary nucleation processes of (chiral) organic compounds in supersaturated solution are consideredfollowed by crystal growth in the presence of tailor-made additives. A representative example of a DutchResolution is presented, the concept of families of resolving agents is defined and examples are given.The phenomenon of reversed Dutch Resolution, resolution of mixtures of families of racemates, is illustrated.The roles of both solid solution formation and nucleation inhibition in Dutch Resolution are discussed.The work is concluded with the results of a broadly based search for nucleation inhibitors for phenylethylamine as resolving agent. This search can serve as a model for the discovery of nucleation inhibitorsfor other resolving agents. The specific role of bifunctional family members of resolving agents as possiblenucleation inhibitors is also discussed.
authors.affiliation: Syncom BV, Kadijk 3, 9747, Groningen AT, The Netherlands, r.m.kellogg@syncom.nl.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Kellogg
authors.forename: Bernard
authors.initials: B
authors.lastname: Kaptein
authors.forename: Ton R
authors.initials: TR
authors.lastname: Vries