title: Primary exertional headache: updates in the literature.
abstract: Primary exertional headache (PEH) has been recognized by the International Headache Society as a primary headache diagnosis since 1994. It is an uncommon, self-limited, and short-lasting disorder that is precipitated by exertion and is frequently comorbid with migraine. PEH shares a number of features with other headache disorders, including thunderclap headache, primary cough headache, and headache associated with sexual activity. Upon its initial occurrence, PEH requires a thorough neurologic evaluation and imaging studies to help eliminate possible underlying secondary causes, including subarachnoid hemorrhage and sentinel bleed. Although PEH is incompletely understood with regard to its epidemiology and pathophysiology, it is generally considered to be a benign disorder that is self-limited and responsive to trigger avoidance and indomethacin.
authors.affiliation: Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA. halker.rashmi@mayo.edu
authors.forename: Rashmi B
authors.initials: RB
authors.lastname: Halker
authors.forename: Bert B
authors.initials: BB
authors.lastname: Vargas
mesh_terms: D015897:Comorbidity; D003937:Diagnosis, Differential; D005260:Female; D051270:Headache Disorders, Primary / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D008881:Migraine Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D059906:Neuroimaging; D013345:Subarachnoid Hemorrhage / Q000175:diagnosis* / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
chemical_list: D007213:Indomethacin