title: Glucose variability.
abstract: The proposed contribution of glucose variability to the development of the complications of diabetes beyond that of glycemic exposure is supported by reports that oxidative stress, the putative mediator of such complications, is greater for intermittent as opposed to sustained hyperglycemia. Variability of glycemia in ambulatory conditions defined as the deviation from steady state is a phenomenon of normal physiology. Comprehensive recording of glycemia is required for the generation of any measurement of glucose variability. To avoid distortion of variability to that of glycemic exposure, its calculation should be devoid of a time component.
authors.affiliation: Mayo College of Medicine, Mayo Clinic, Rochester, Minnesota, USA. service.john@ mayo.edu
authors.forename: F John
authors.initials: FJ
authors.lastname: Service
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D002940:Circadian Rhythm; D048909:Diabetes Complications / Q000209:etiology / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000097:blood / Q000178:diet therapy / Q000188:drug therapy / Q000628:therapy*; D003927:Diet, Diabetic; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology* / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D018384:Oxidative Stress; D018570:Risk Assessment
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents