title: B cell-derived cytokines in disease.
abstract: B cells regulate immune responses during infectious, inflammatory and autoimmune diseases. Beside their unique and characteristic antibody production, B lymphocytes can modulate physiological and pathological processes by presenting antigens or synthesizing signaling molecules. In human and mouse diseases, immuno-intervention, targeting B cells, has revealed and highlighted their antibody-independent regulatory contribution. In this review, we focus on B cell-cytokine production, which is commonly disturbed in inflammatory disorders, and describe the B cell cytokine profile in different diseases. Finally, we discuss some key issues for future B cell-targeted therapies.
authors.affiliation: Centre de Pharmacologie & Innovation dans le Diabète FRE 3400 CNRS MontpellierFrance.
authors.forename: Moustafa
authors.initials: M
authors.lastname: Hamze
authors.forename: Caroline
authors.initials: C
authors.lastname: Desmetz
authors.forename: Paul
authors.initials: P
authors.lastname: Guglielmi
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D004194:Disease; D006801:Humans
chemical_list: D016207:Cytokines
keywords: B lymphocyte; autoimmunity; cancer; inflammation