title: [Ursolic acid as antitumor agent and inductor of PTEN and brown fat].
abstract: In this mini-review the basic evidence about anticancer properties of ursolic acid (UA), the compound belonging to the class of triterpenoids, is given. Beside inhibiting tumor cell growth in vitro and in vivo and activating of apoptosis, UA (as well as some other related and not related compounds) is capable to induce PTEN (a tumor suppressor mutation of which is rather often discovered in human tumors including endometrial cancer type I) and amount/activity of brown fat. The latter action may explain obesity-preventing capacity of UA that also may lead to an additional antiblastomogenic effect.
authors.forename: L M
authors.initials: LM
authors.lastname: Bershteĭn
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D009154:Mutation / Q000187:drug effects*; D009765:Obesity / Q000517:prevention & control; D051059:PTEN Phosphohydrolase / Q000187:drug effects* / Q000378:metabolism; D014315:Triterpenes / Q000494:pharmacology*; D025521:Tumor Suppressor Proteins / Q000187:drug effects* / Q000378:metabolism; D000097245:Ursolic Acid
chemical_list: D000970:Antineoplastic Agents; D051059:PTEN Phosphohydrolase; D014315:Triterpenes; D025521:Tumor Suppressor Proteins; D000097245:Ursolic Acid; C494929:PTEN protein, human