title: Nonmelanoma skin cancer in childhood after hematopoietic stem cell transplant: a report of 4 cases.
abstract: Although it is known that hematopoietic stem cell transplantation (HSCT) survivors are at risk of nonmelanoma skin cancer (NMSC), there is limited literature on the incidence of NMSC during childhood in this population. We present 4 HSCT patients ages 13 to 20 years diagnosed with NMSC in our clinic over a 1-year period. Each patient had multiple risk factors associated with NMSC including chronic graft-versus-host disease, prolonged immunosuppression, total-body irradiation, and voriconazole therapy. We conclude that the incidence of NMSC in children after HSCT may be underestimated and should be further investigated. Appropriate skin cancer screening, including annual skin examinations, are advised for pediatric patients with identifiable risk factors.
authors.affiliation: *Dermatology Program, Harvard Medical School, Boston Children's Hospital †Department of Hematology/Oncology, Harvard Medical School, Boston Children's Hospital, Dana-Farber Cancer Institute ‡Harvard Combined Dermatology Residency Program, Department of Dermatology, Harvard Medical School, Boston, MA.
authors.forename: Jillian F
authors.initials: JF
authors.lastname: Rork
authors.forename: Steven P
authors.initials: SP
authors.lastname: Margossian
authors.forename: Vinod E
authors.initials: VE
authors.lastname: Nambudiri
authors.forename: Jennifer T
authors.initials: JT
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage; D001900:Boston / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000150:complications; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D011743:Pyrimidines / Q000008:administration & dosage; D012307:Risk Factors; D012878:Skin Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D015996:Survival Rate; D017741:Survivors; D014230:Triazoles / Q000008:administration & dosage; D065819:Voriconazole; D014916:Whole-Body Irradiation; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole