title: Normal and polar-organic-phase high-performance liquid chromatographic enantioresolution of omeprazole, rabeprazole, lansoprazole and pantoprazole using monochloro-methylated cellulose-based chiral stationary phase and determination of dexrabeprazole.
abstract: Enantioresolution of four anti-ulcer drugs (chiral sulfoxides), namely, omeprazole, rabeprazole, lansoprazole and pantoprazole, was carried out by high-performance liquid chromatography using a polysaccharide-based chiral stationary phase consisting of monochloromethylated cellulose (Lux cellulose-2) under normal and polar-organic-phase conditions with ultraviolet detection at 285 nm. The method was validated for linearity, accuracy, precision, robustness and limit of detection. The optimized enantioresolution method was compared for both the elution modes. The optimized method was further utilized to check the enantiomeric purity of dexrabeprazole.
authors.affiliation: Department of Chemistry, Yeungnam University, Gyeongsan, 712-749, South Korea.
authors.forename: Shuchi
authors.initials: S
authors.lastname: Dixit
authors.forename: Rituraj
authors.initials: R
authors.lastname: Dubey
authors.forename: Ravi
authors.initials: R
authors.lastname: Bhushan
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000737:chemistry*; D000897:Anti-Ulcer Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D064747:Lansoprazole / Q000737:chemistry*; D009853:Omeprazole / Q000737:chemistry*; D000077402:Pantoprazole; D064750:Rabeprazole / Q000032:analysis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D064747:Lansoprazole; D064750:Rabeprazole; D000077402:Pantoprazole; D009853:Omeprazole
keywords: chiral sulfoxides; dexrabeprazole; enantioresolution; high-performance liquid chromatography; monochloro methylated cellulose as chiral stationary phase