title: 1912-2012: a century of research on Plasmodium vivax in vitro culture.
abstract: The development of a continuous Plasmodium vivax blood cycle in vitro was first attempted 100 years ago. Since then, and despite the use of different methods, only short-term cultures have been achieved so far. The available literature has been reviewed in order to provide a critical overview of the currently available knowledge on P. vivax blood cycle culture systems and identify some unexplored ways forward. Results show that data accumulated over the past century remain fragmented and often contradictory, making it difficult to draw conclusions. There is the need for an international consortium on P. vivax culture able to collect, update, and share new evidence, including negative results, and thus better coordinate current efforts towards the establishment of a continuous P. vivax culture.
authors.affiliation: Unit of Malariology, Institute of Tropical Medicine, Antwerp, 2000, Belgium. fnoulin@itg.be
authors.forename: Florian
authors.initials: F
authors.lastname: Noulin
authors.forename: Céline
authors.initials: C
authors.lastname: Borlon
authors.forename: Jan
authors.initials: J
authors.lastname: Van Den Abbeele
authors.forename: Umberto
authors.initials: U
authors.lastname: D'Alessandro
authors.forename: Annette
authors.initials: A
authors.lastname: Erhart
mesh_terms: D000818:Animals; D049673:History, 20th Century; D049674:History, 21st Century; D008018:Life Cycle Stages / Q000502:physiology; D016780:Malaria, Vivax / Q000266:history / Q000469:parasitology*; D010966:Plasmodium vivax / Q000254:growth & development / Q000502:physiology*; D012106:Research / Q000266:history