title: Sinonasal cancer: Analysis of oncological failures in 156 consecutive cases.
abstract: BACKGROUND
  Sinonasal cancers are rare and associated with a poor prognosis. The purpose of this study was to report our experience and analyze the risk factors for oncologic failures.
  
  
  METHODS
  A retrospective review of 156 consecutive patients treated with curative intent for sinonasal malignancy between 1995 and 2005 at tertiary cancer center was performed. Demographic, clinical, morphological, and pathological parameters were correlated with oncologic outcomes.
  
  
  RESULTS
  Complete response was obtained for 134 patients. Sixty-eight patients relapsed, among which 51 had local recurrence. Nine of these 51 patients (17.6%) underwent successful salvage therapy. Five-year local failure and overall survival rates were 50.0% and 61.1%, respectively. Maxillary sinus tumors, intracranial invasion, and N > 0 classification at initial diagnosis were significantly and independently associated with local failure and survival in multivariate analysis.
  
  
  CONCLUSIONS
  Local control after initial treatment is primordial to optimizing outcomes because of the poor results of salvage therapy.
authors.affiliation: Head and Neck Department, Institut Gustave Roussy, Villejuif, France.
authors.forename: Haïtham
authors.initials: H
authors.lastname: Mirghani
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Mortuaire
authors.forename: Gian Luca
authors.initials: GL
authors.lastname: Armas
authors.forename: Dana
authors.initials: D
authors.lastname: Hartl
authors.forename: Anne
authors.initials: A
authors.lastname: Aupérin
authors.forename: Sophie
authors.initials: S
authors.lastname: El Bedoui
authors.forename: Dominique
authors.initials: D
authors.lastname: Chevalier
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Lefebvre
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002173:Cancer Care Facilities; D059248:Chemoradiotherapy / Q000379:methods; D015331:Cohort Studies; D003131:Combined Modality Therapy; D016001:Confidence Intervals; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D016016:Proportional Hazards Models; D020266:Radiotherapy, Conformal; D012189:Retrospective Studies; D018570:Risk Assessment; D016879:Salvage Therapy / Q000379:methods* / Q000401:mortality; D015996:Survival Rate; D017211:Treatment Failure; D055815:Young Adult
keywords: local failure; neck prophylactic treatment; oncological failure analyze; poor salvage outcomes; sinonasal cancer