title: Crohn's disease complicated by strictures: a systematic review.
abstract: The occurrence of strictures as a complication of Crohn's disease is a significant clinical problem. No specific antifibrotic therapies are available. This systematic review comprehensively addresses the pathogenesis, epidemiology, prediction, diagnosis and therapy of this disease complication. We also provide specific recommendations for clinical practice and summarise areas that require future investigation.
authors.affiliation: Department of Pathobiology, Lerner Research Institute, NC22, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. riederf@ccf.org
authors.forename: Florian
authors.initials: F
authors.lastname: Rieder
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Zimmermann
authors.forename: Feza H
authors.initials: FH
authors.lastname: Remzi
authors.forename: William J
authors.initials: WJ
authors.lastname: Sandborn
mesh_terms: D003251:Constriction, Pathologic / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D003424:Crohn Disease / Q000150:complications* / Q000628:therapy; D005355:Fibrosis; D006801:Humans; D007422:Intestines / Q000473:pathology*; D012307:Risk Factors
keywords: Crohn's colitis; Fibrogenesis; Fibrosis; IBD Clinical