title: Evaluation of the role of radiotherapy in the management of dermatofibrosarcoma protuberans.
abstract: OBJECTIVE
  The aim of this study was to evaluate the role of radiotherapy (RT) in the management of dermatofibrosarcoma protuberans (DFSP).
  
  
  METHODS
  Twenty-eight patients treated with RT for DFSP between 1974 and 2012 at Gulhane Military Medical Academy (GMMA) Radiation Oncology Department were retrospectively evaluated. Twenty-five out of 28 patients (89%) received postoperative RT and 3 received definitive RT alone. In the 25 patients receiving postoperative RT, the type of surgical excision was limited excision in 5 patients and wide excision in the remaining 20. Median RT dose was 63.21±3.7 Gy (range 50-70).
  
  
  RESULTS
  At a median follow-up of 5 years, 5-year overall survival (OS) for the whole patient group was 93%. No relationship was determined between the total delivered RT dose and OS. The 5-year OS of the 10 female patients was 90% whereas it was 94% for the 18 male patients (p>0.05). Five-year disease-free survival (DFS) for the patients undergoing wide excision with RT vs. those undergoing limited excision with RT was significantly superior (p <0.05) in patients treated with wide excision and RT.
  
  
  CONCLUSIONS
  RT is an effective treatment option for DFSP patients with positive postoperative margins, recurrent disease and selected inoperable cases.
authors.affiliation: Department of Radiation Oncology, Gulhane Military Medical Academy, Ankara, Turkey. drborauysal@windowslive.com
authors.forename: B
authors.initials: B
authors.lastname: Uysal
authors.forename: O
authors.initials: O
authors.lastname: Sager
authors.forename: H
authors.initials: H
authors.lastname: Gamsiz
authors.forename: A
authors.initials: A
authors.lastname: Cicek
authors.forename: S
authors.initials: S
authors.lastname: Demiral
authors.forename: F
authors.initials: F
authors.lastname: Dincoglan
authors.forename: S
authors.initials: S
authors.lastname: Surenkok
authors.forename: M
authors.initials: M
authors.lastname: Demiriz
authors.forename: M
authors.initials: M
authors.lastname: Beyzadeoglu
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D018223:Dermatofibrosarcoma / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D018365:Neoplasm, Residual; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000532:radiotherapy*; D016019:Survival Analysis; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014421:Turkey; D055815:Young Adult