title: Unexpected loss of contact allergy to aluminium induced by vaccine.
abstract: BACKGROUND
  In studies in Gothenburg, Sweden, in the 1990s of an aluminium hydroxide-adsorbed pertussis toxoid vaccine, 745 of ~76 000 vaccinated children developed long-lasting itchy subcutaneous nodules at the vaccination site. Of 495 children with itchy nodules patch tested for aluminium allergy, 376 (76%) were positive.
  
  
  OBJECTIVE
  To study the prognosis of the vaccine-induced aluminium allergy.
  
  
  METHODS
  Two hundred and forty-one children with demonstrated aluminium allergy in the previous study were patch tested again 5-9 years after the initial test, with the same procedure as used previously.
  
  
  RESULTS
  Contact allergy to aluminium was no longer demonstrable in 186 of the retested 241 children (77%). A negative test result was more common in children who no longer had itching at the vaccination site; it was also related to the age of the child, the time after the first aluminium-adsorbed vaccine dose, and the strength of the reaction in the first test.
  
  
  CONCLUSIONS
  Patch test reactivity to aluminium seems to disappear or weaken with time.
authors.affiliation: Department of Dermatology and Venereology, Sahlgrenska University Hospital, S-413 45 Gothenburg, Sweden. anette.gente.lidholm@vgregion.se
authors.forename: Anette
authors.initials: A
authors.lastname: Gente Lidholm
authors.forename: Elisabet
authors.initials: E
authors.lastname: Bergfors
authors.forename: Annica
authors.initials: A
authors.lastname: Inerot
authors.forename: Ulla
authors.initials: U
authors.lastname: Blomgren
authors.forename: Martin
authors.initials: M
authors.lastname: Gillstedt
authors.forename: Birger
authors.initials: B
authors.lastname: Trollfors
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000293:Adolescent; D017607:Aluminum Compounds / Q000008:administration & dosage*; D002648:Child; D017449:Dermatitis, Allergic Contact / Q000276:immunology* / Q000517:prevention & control*; D003888:Desensitization, Immunologic; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D008297:Male; D010328:Patch Tests; D011379:Prognosis; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D017607:Aluminum Compounds; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines