title: A child with Epstein-Barr Virus-associated hemophagocytic lymphohistiocytosis complicated by coronary artery lesion mimicking Kawasaki disease.
abstract: There is considerable overlap between hemophagocytic lymphohistiocytosis (HLH) and Kawasaki disease (KD) in terms of aberrant immune response though the etiology of KD remains unknown. We present a case fulfilling the criteria of both HLH and KD complicated by coronary artery dilatation: HLH was confirmed to be triggered by Epstein-Barr virus. This case alarms us the possibility that even patients with HLH may be complicated by coronary artery lesion, which is one of the hallmarks of KD. We would like to draw attention that if features of KD become apparent in patients with HLH, echocardiographic examinations should be performed not to miss coronary artery lesion.
authors.affiliation: Department of Pediatrics, Kansai Medical University, Osaka, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Kato
authors.forename: Ken
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tanabe
authors.forename: Takahisa
authors.initials: T
authors.lastname: Kimata
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Noda
authors.forename: Hirohide
authors.initials: H
authors.lastname: Kawasaki
authors.forename: Kazunari
authors.initials: K
authors.lastname: Kaneko
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000150:complications* / Q000175:diagnosis*; D003331:Coronary Vessels / Q000473:pathology; D004452:Echocardiography; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D009080:Mucocutaneous Lymph Node Syndrome / Q000175:diagnosis*; D016896:Treatment Outcome