title: Manipulation of cellular processing bodies and their constituents by viruses.
abstract: The processing bodies (PBs) are a form of cytoplasmic aggregates that house the cellular RNA decay machinery as well as many RNA-binding proteins and mRNAs. The PBs are constitutively present in eukaryotic cells and are involved in maintaining cellular homeostasis by regulating RNA metabolism, cell signaling, and survival. Virus infections result in modification of the PBs and their constituents. Many viruses induce compositionally altered PBs, while many others use specific components of the PBs for their replication. PB constituents are also known to restrict virus replication by a variety of mechanisms. Further, continuing studies in this rapidly emerging field of PB-virus interactions will undoubtedly provide important clues to the understanding of the role of PBs in cellular homeostasis as well as their role in virus infections and innate immune signaling.
authors.affiliation: School of Veterinary Medicine and Biomedical Sciences and the Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583-0900, USA. apattnaik2@unl.edu
authors.forename: Asit K
authors.initials: AK
authors.lastname: Pattnaik
authors.forename: Phat X
authors.initials: PX
authors.lastname: Dinh
mesh_terms: D000071478:APOBEC Deaminases; D003564:Cytidine Deaminase; D003594:Cytoplasmic Granules / Q000378:metabolism* / Q000821:virology*; D043525:Cytosine Deaminase / Q000378:metabolism; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism; D014777:Virus Diseases / Q000378:metabolism; D014779:Virus Replication
chemical_list: D012333:RNA, Messenger; D014764:Viral Proteins; D043525:Cytosine Deaminase; D000071478:APOBEC Deaminases; C502889:APOBEC3 proteins, human; D003564:Cytidine Deaminase