title: Mercaptoethanol capped CdSe quantum dots and CdSe/ZnS core/shell: synthesis, characterization and cytotoxicity evaluation.
abstract: CdSe Quantum dots (Q-dots) and CdSe/ZnS core/shell have been synthesized by wet chemical route using mercaptoethanol (ME) as cappant. The synthesized Q-dots and core/shell were characterized using X-ray diffraction (XRD), Transmission electron microscopy (TEM), Energy dispersive X-ray analysis (EDS), Dynamic Light Scattering (DLS), Optical absorption and luminescence spectroscopy. The core/shell formation was confirmed by both XRD and TEM analysis. The luminescence was shown to be considerably enhanced in the core/shell sample. Effect of dialysis process on the optical properties of the Q-dots and core/shell has also been discussed. Cytotoxicity studies have been carried out for Q-dots and core/shell. CdSe/ZnS core/shell was found to be non-cytotoxic as compared to CdSe Q-dots up to a certain concentration range. Polyethylene glycol (PEG) coating enhances the non-cytotoxic nature of CdSe/ZnS core/shell when compared with bare core/shell.
authors.affiliation: Dental Products Laboratory, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Trivandrum 695012, India.
authors.forename: Diksha
authors.initials: D
authors.lastname: Painuly
authors.forename: Anugya
authors.initials: A
authors.lastname: Bhatt
authors.forename: V Kalliyana
authors.initials: VK
authors.lastname: Krishnan
mesh_terms: D000042:Absorption; D000818:Animals; D019187:Cadmium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D016923:Cell Death / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology; D006801:Humans; D008623:Mercaptoethanol / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D045663:Quantum Dots; D051381:Rats; D018036:Selenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D013052:Spectrometry, X-Ray Emission; D055672:Static Electricity; D013440:Sulfides / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D014961:X-Ray Diffraction; D017967:Zinc Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*
chemical_list: D019187:Cadmium Compounds; D018036:Selenium Compounds; D013440:Sulfides; D017967:Zinc Compounds; D008623:Mercaptoethanol; C058667:cadmium selenide; C031238:zinc sulfide