title: Single spin-echo T2 relaxation times of cerebral metabolites at 14.1 T in the in vivo rat brain.
abstract: OBJECTIVE
  To determine the single spin-echo T2 relaxation times of uncoupled and J-coupled metabolites in rat brain in vivo at 14.1 T and to compare these results with those previously obtained at 9.4 T.
  
  
  METHODS
  Measurements were performed on five rats at 14.1 T using the SPECIAL sequence and TE-specific basis-sets for LCModel analysis.
  
  
  CONCLUSIONS
  The T2 of singlets ranged from 98 to 148 ms and T2 of J-coupled metabolites ranged from 72 ms (glutamate) to 97 ms (myo-inositol). When comparing the T2s of the metabolites measured at 14.1 T with those previously measured at 9.4 T, a decreasing trend was found (p<0.0001). We conclude that the modest shortening of T2 at 14.1 T has a negligible impact on the sensitivity of the 1H MRS when performed at TE shorter than 10 ms.
authors.affiliation: Departments of Radiology, University of Lausanne, Lausanne, Switzerland, lijing.xin@epfl.ch.
authors.forename: Lijing
authors.initials: L
authors.lastname: Xin
authors.forename: Giulio
authors.initials: G
authors.lastname: Gambarota
authors.forename: Cristina
authors.initials: C
authors.lastname: Cudalbu
authors.forename: Vladimír
authors.initials: V
authors.lastname: Mlynárik
authors.forename: Rolf
authors.initials: R
authors.lastname: Gruetter
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D007294:Inositol / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011522:Protons; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D011522:Protons; D018698:Glutamic Acid; D007294:Inositol; D003401:Creatine; D002794:Choline