title: Perinatal taurine exposure affects adult oxidative stress.
abstract: Perinatal exposure to taurine (a β-amino acid) can alter adult physiological functions, including arterial pressure, hormonal and renal functions. Whereas perinatal taurine supplementation appears to have only minor effects on adult physiology, perinatal taurine depletion is associated with multiple adverse health effects, especially in animals postnatally exposed to other insults. New studies indicate that the mechanism for many of the physiological effects of taurine is related to the antioxidant activity of taurine. Thus the perinatal taurine depletion leads to oxidative stress in adult animals. It is likely that perinatal taurine depletion increases oxidative stress throughout life and that the early life taurine depletion leads to perinatal, epigenetic programming that impacts adult physiological function.
authors.affiliation: Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Wichaporn
authors.initials: W
authors.lastname: Lerdweeraphon
authors.forename: James Michael
authors.initials: JM
authors.lastname: Wyss
authors.forename: Thidarut
authors.initials: T
authors.lastname: Boonmars
authors.forename: Sanya
authors.initials: S
authors.lastname: Roysommuti
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism*; D013654:Taurine / Q000008:administration & dosage* / Q000172:deficiency
chemical_list: D013654:Taurine
keywords: arterial pressure; hypertension; oxidative stress; perinatal exposure; taurine