title: Curcumin inhibits UVB-induced matrix metalloproteinase-1/3 expression by suppressing the MAPK-p38/JNK pathways in human dermal fibroblasts.
abstract: Curcumin (diferuloylmethane) is a polyphenol derived from turmeric (Curcuma longa), which is commonly used as a spice. Recent studies have shown that curcumin has a wide range of pharmacological activities, including anticarcinogenic, antioxidant, anti-inflammatory and antiangiogenic activities. However, the antiphotoageing effects of curcumin have yet to be characterized. In this study, we investigated the inhibitory effects of curcumin on matrix metalloproteinase (MMP)-1 and MMP-3 expression in human dermal fibroblast cells. Western blot analysis revealed that curcumin inhibited ultraviolet (UV) B-induced MMP-1 and MMP-3 expression. Furthermore, curcumin significantly blocked UVB-induced reactive oxygen species generation in fibroblasts. Curcumin treatment significantly blocked the UVB-induced activation of nuclear factor (NF)-κB and activator protein (AP)-1. Additionally, curcumin strongly repressed the UVB-induced phosphorylation of p38 and c-Jun N-terminal kinase. Curcumin prevented UVB-induced MMP expression through mitogen-activated protein kinase/NF-κB inhibition and AP-1 activation. In conclusion, curcumin may be useful for preventing and treating skin photoageing.
authors.forename: Bo-Mi
authors.initials: BM
authors.lastname: Hwang
authors.forename: Eun-Mi
authors.initials: EM
authors.lastname: Noh
authors.forename: Jong-Suk
authors.initials: JS
authors.lastname: Kim
authors.forename: Jeong-Mi
authors.initials: JM
authors.lastname: Kim
authors.forename: Yong-Ouk
authors.initials: YO
authors.lastname: You
authors.forename: Jin-Ki
authors.initials: JK
authors.lastname: Hwang
authors.forename: Kang-Beom
authors.initials: KB
authors.lastname: Kwon
authors.forename: Young-Rae
authors.initials: YR
authors.lastname: Lee
mesh_terms: D003474:Curcumin / Q000494:pharmacology*; D020405:Dermis / Q000166:cytology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D052816:Foreskin / Q000166:cytology; D006801:Humans; D020935:MAP Kinase Signaling System / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism*; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D048051:p38 Mitogen-Activated Protein Kinases; C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1; D003474:Curcumin