title: Non-solid lung nodules on low-dose computed tomography: comparison of detection rate between 3 visualization techniques.
abstract: OBJECTIVE
  To compare various visualization techniques for the detection of non-solid nodules in low-dose lung cancer screening computed tomography (CT) scans.
  
  
  METHODS
  An enriched sample of 216 male lung cancer screening subjects aged 60.4 ± 6.0 years was used. Two blinded independent readers searched for non-solid nodules on 5-mm multiplanar reconstructions, 1-mm slices and 7-mm maximum intensity projections (trial protocol). The reference standard was a consensus diagnosis of all non-solid nodules reported at least once.
  
  
  RESULTS
  Twenty-three individuals (10.6%) had in total 34 non-solid nodules. Interobserver agreement was good (Cohen kappa 0.89-0.95). For both observers, we found no differences between the 3 viewing techniques (P > 0.13).
  
  
  CONCLUSIONS
  In low-dose lung cancer screening CT scans, we were unable to find a viewing technique superior to that used in the trial by experienced observers who focused on non-solid nodule detection.
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors.forename: Ernst Th
authors.initials: ET
authors.lastname: Scholten
authors.forename: Willem P Th M
authors.initials: WP
authors.lastname: Mali
authors.forename: Mathias
authors.initials: M
authors.lastname: Prokop
authors.forename: Bram
authors.initials: B
authors.lastname: van Ginneken
authors.forename: Ron
authors.initials: R
authors.lastname: Glandorf
authors.forename: Rob
authors.initials: R
authors.lastname: van Klaveren
authors.forename: Matthijs
authors.initials: M
authors.lastname: Oudkerk
authors.forename: Pim A
authors.initials: PA
authors.lastname: de Jong
mesh_terms: D000368:Aged; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*