title: Linking survival and biomarker responses over time.
abstract: The practical usefulness of biomarkers is limited by the complexity of linking their responses to life-history traits of the organisms (e.g., survival, growth, reproduction) over time. Here the authors present a first attempt to model biomarker responses and survival over time simultaneously with a toxicokinetic-toxicodynamic approach. Even though more work is clearly needed, the present study provides a novel direction for interpreting biomarker responses and dynamically linking them to life-history traits.
authors.affiliation: Department of Theoretical Biology, VU University Amsterdam, Amsterdam, The Netherlands. tjalling.jager@vu.nl
authors.forename: Tjalling
authors.initials: T
authors.lastname: Jager
authors.forename: Bjørn Henrik
authors.initials: BH
authors.lastname: Hansen
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000633:toxicity*; D008954:Models, Biological; D010599:Pharmacokinetics; D012098:Reproduction
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants
keywords: Biomarker; Copepods; Glutathione S-transferase; Survival; Toxicokinetic-toxicodynamic modeling