title: Transmission of human mitochondrial DNA along the paternal lineage in transmitochondrial mice.
abstract: Previously we obtained heteroplasmic mice carrying murine and human mitochondrial DNA (mtDNA). Even the fourth generation of such mice had human mtDNA in their organs, hence, they were used to study the possibility of paternal mtDNA transmission. A lineage was obtained in which human mtDNA was transmitted by males to the progeny in four successive generations. This is the first observation of such a continuous paternal transmission of mtDNA. Persistence of paternal mtDNA in several successive generations of animals suggests that mechanisms aimed at elimination of paternally inherited mtDNA species are not as strict as has been postulated.
authors.affiliation: Department of Molecular Genetics, Institute for Experimental Medicine, 12 Pavlov Street, Saint-Petersburg 197376, Russia.
authors.forename: Oxana V
authors.initials: OV
authors.lastname: Kidgotko
authors.forename: Maria Ye
authors.initials: MY
authors.lastname: Kustova
authors.forename: Vassilina A
authors.initials: VA
authors.lastname: Sokolova
authors.forename: Mikhail G
authors.initials: MG
authors.lastname: Bass
authors.forename: Vadim B
authors.initials: VB
authors.lastname: Vasilyev
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics*; D005111:Extrachromosomal Inheritance; D005260:Female; D042822:Genomic Instability; D008297:Male; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D004272:DNA, Mitochondrial