title: [Roles of phosphatidylethanolamine-binding protein in cell signaling and its biological functions].
abstract: Phosphatidylethanolamine-binding protein (PEBP) is a cytoplasm soluble protein with a high conserved structure. It has been approved recently that PEBP is a multifunctional molecule regulating several important cellular signal pathways, including ERK cascade, NF-κB pathway, and signaling of G protein-coupled receptors. Furthermore, the role of PEBP in tumor metastasis also got a comprehensive attention in the field of clinical cancer research. Together, as a signal regulator at multiple paths in cell, PEBP is becoming a new focus in several research fields. This review is aimed to introduce the newest biological progress on PEBP.
authors.affiliation: Department of Pharmacology, Military General Hospital of Beijing PLA, Beijing 100700, China.
authors.forename: Jia-Ming
authors.initials: JM
authors.lastname: Bian
authors.forename: Ning
authors.initials: N
authors.lastname: Wu
authors.forename: Jin
authors.initials: J
authors.lastname: Li
mesh_terms: D006801:Humans; D020935:MAP Kinase Signaling System; D016328:NF-kappa B / Q000502:physiology; D009369:Neoplasms; D049488:Phosphatidylethanolamine Binding Protein / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D015398:Signal Transduction
chemical_list: D016328:NF-kappa B; D049488:Phosphatidylethanolamine Binding Protein; D043562:Receptors, G-Protein-Coupled