title: Presenting ADAMTS13 on a TTP-associated MHC.
abstract: In this issue of Blood, Sorvillo et al investigate possible molecular triggers leading to idiopathic, autoimmune thrombotic thrombocytopenic purpura (TTP) by identifying naturally processed A Disintegrin And Metalloprotease with ThromboSpondin type 1 motif 13 (ADAMTS13)-derived peptides presented on human dendritic cells.
authors.affiliation: Puget Sound Blood Center Research Institute
authors.forename: Kathleen P
authors.initials: KP
authors.lastname: Pratt
mesh_terms: D051722:ADAM Proteins / Q000276:immunology*; D000071120:ADAMTS13 Protein; D003713:Dendritic Cells / Q000276:immunology*; D059811:HLA-DRB1 Chains / Q000276:immunology*; D006801:Humans; D010446:Peptide Fragments / Q000276:immunology*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology*; D012697:Serine Endopeptidases / Q000276:immunology
chemical_list: D059811:HLA-DRB1 Chains; D010446:Peptide Fragments; C445579:CUB-serine protease, Panulirus argus; D012697:Serine Endopeptidases; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human