title: Structure of the O-antigen of a novel Shigella flexneri serotype, 1d (I: 7,8).
abstract: Recently, strains of a novel Shigella flexneri serotype called 1d have been isolated from diarrheal patients in China. They are distinguished by the presence of a hitherto unknown combination of type O-factor I and group O-factor 7,8, both associated with lateral α-D-glucosyl groups on the basal linear O-polysaccharide. A serologically identical strain, 036_1d, has been constructed in the laboratory by sequential infection of serotype Y by serotype-converting bacteriophages SfX and SfI. In this work, using 1D and 2D (1)H and (13)C NMR spectroscopy, we established the following structure of the O-antigen of S. flexneri serotype 1d and demonstrated that the O-antigen of the 036_1d construct has the same structure: [structure: see text].
authors.affiliation: ND Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Shashkov
authors.forename: Sof'ya N
authors.initials: SN
authors.lastname: Senchenkova
authors.forename: Qiangzheng
authors.initials: Q
authors.lastname: Sun
authors.forename: Ruiting
authors.initials: R
authors.lastname: Lan
authors.forename: Jianping
authors.initials: J
authors.lastname: Wang
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Perepelov
authors.forename: Yuriy A
authors.initials: YA
authors.lastname: Knirel
authors.forename: Jianguo
authors.initials: J
authors.lastname: Xu
mesh_terms: D002240:Carbohydrate Sequence; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D019081:O Antigens / Q000737:chemistry*; D012703:Serotyping; D012763:Shigella flexneri / Q000737:chemistry / Q000145:classification / Q000276:immunology*
chemical_list: D019081:O Antigens