title: Functional neuroimaging of migraine.
abstract: This review summarizes the history of migraine imaging and key findings of studies on functional neuroimaging in migraine and describes how these data have changed our view of the disorder. Functional neuroimaging during migraine attacks and also interictally has initiated the description of "the migraine brain". These studies have led to the demonstration of cortical spreading depression in migraine with aura, the crucial role for the brainstem during migraine attacks, and cortical hypersensitivity in migraineurs modulated by the trigeminal pathway, explaining sensory sensitization such as photophobia and osmophobia.
authors.affiliation: Service de neurologie et d'explorations fonctionnelles neurologiques, hôpital de Rangueil, CHU Toulouse Rangueil, 1, avenue Jean-Poulhès, TSA 50032, 31059 Toulouse cedex 9, France. denuelle.m@chu-toulouse.fr
authors.forename: M
authors.initials: M
authors.lastname: Denuelle
authors.forename: N
authors.initials: N
authors.lastname: Fabre
mesh_terms: D001933:Brain Stem / Q000502:physiology / Q000503:physiopathology; D002908:Chronic Disease; D013181:Cortical Spreading Depression / Q000502:physiology; D059907:Functional Neuroimaging / Q000266:history / Q000379:methods; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008881:Migraine Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D020795:Photophobia / Q000150:complications / Q000209:etiology