title: A comprehensive search for recombinogenic motifs in the human genome.
abstract: The patterns of male and female recombination vary greatly on a macro scale. A unique motif in each gender, triggering a double strand break at its location, much in the way Chi sites operate in E. coli, could logically explain this difference. As such, we have undertaken a comprehensive search of all small motifs in an attempt to identify one or more that match to the available data. In the end, we conclude that no such motifs appear to exist in the human genome.
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
authors.forename: Henry R
authors.initials: HR
authors.lastname: Johnston
authors.forename: David J
authors.initials: DJ
authors.lastname: Cutler
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping; D005260:Female; D015894:Genome, Human; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D059372:Nucleotide Motifs; D056510:Position-Specific Scoring Matrices; D011995:Recombination, Genetic; D012737:Sex Factors