title: Subjective well-being, but not subjective mental functioning shows positive associations with neuropsychological performance in schizophrenia-spectrum disorders.
abstract: OBJECTIVE
  To assess the association of subjective quality of life as measured by the Subjective Well-being under Neuroleptic Treatment questionnaire (SWN-K) with neuropsychological functioning; to address interactions with the SWN-K domain mental functioning as a measure of subjective cognitive dysfunction; and to examine the interaction of subjective well-being and psychopathology ratings.
  
  
  METHODS
  Forty-five patients diagnosed with schizophrenia spectrum disorder (SSD) were assessed regarding subjective well-being (SWN-K), neuropsychological impairment, and psychopathology (Brief Psychiatric Rating Scale; BPRS).
  
  
  RESULTS
  After controlling for multiple comparisons, SWN-K total score showed significant positive correlations with concentration/attention (r=.498), working memory (r=.537), verbal memory (r=.522), and global cognition (r=.459). No correlations of SWN mental functioning and neuropsychological impairment remained significant after Bonferroni correction. Correlations between SWN-K subscales and neuropsychological functioning were generally positive, indicating higher subjective well-being in patients with better neurocognition. In multivariate analyses, global cognition was a significant predictor (p=.011), accounting for 19.7% of SWN total score variance. Adding BPRS total score as predictor (p=.054) explained an additional 6.9% of SWN-K variance. Linear regression analyses with SWN-K mental functioning as dependent variable did not yield statistically significant models.
  
  
  CONCLUSIONS
  Subjective well-being and objective neuropsychological functioning show only moderate associations and can be seen as largely independent parameters. In particular, subjective mental functioning cannot serve as a proxy for objective neuropsychological testing.
authors.affiliation: Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: katrin.schroeder@uke-hh.de.
authors.forename: Katrin
authors.initials: K
authors.lastname: Schroeder
authors.forename: Christian G
authors.initials: CG
authors.lastname: Huber
authors.forename: Lena
authors.initials: L
authors.lastname: Jelinek
authors.forename: Steffen
authors.initials: S
authors.lastname: Moritz
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect; D003071:Cognition; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010549:Personal Satisfaction; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life / Q000523:psychology*; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index