title: The role of inflammatory chemokines in lymphoid neoorganogenesis in breast cancer.
abstract: The expression profiling analysis of inflammatory chemokines and their receptors in newly formed lymph nodes in breast cancer was carried out. The analysis revealed the increase in expression of the genes CCL16, XCR1, CYFIP2, TNFSF14 and the reduction in expression of chemokine ligands CXCL5 and CXCL12 in tertiary lymphoid organs. The obtained results allow us to suggest that the process of induction of lymph nodes neogenesis is identical (in its key mechanisms) to the process of lymphoid tissue neogenesis in autoimmune diseases and in some infections, but may have different triggers.
authors.affiliation: Scientific Research Institute of Oncology, Bashkortostan State Medical University, Lenina Street 3, 450000 Ufa, Russian Federation.
authors.forename: S K
authors.initials: SK
authors.lastname: Gantsev
authors.forename: K
authors.initials: K
authors.lastname: Umezawa
authors.forename: D V
authors.initials: DV
authors.lastname: Islamgulov
authors.forename: E K
authors.initials: EK
authors.lastname: Khusnutdinova
authors.forename: R S
authors.initials: RS
authors.lastname: Ishmuratova
authors.forename: V Y
authors.initials: VY
authors.lastname: Frolova
authors.forename: S R
authors.initials: SR
authors.lastname: Kzyrgalin
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018925:Chemokines / Q000235:genetics / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism*; D008221:Lymphoid Tissue / Q000378:metabolism; D008875:Middle Aged; D038081:Organogenesis / Q000502:physiology; D019707:Receptors, Chemokine / Q000235:genetics / Q000378:metabolism*
chemical_list: D018925:Chemokines; D018836:Inflammation Mediators; D019707:Receptors, Chemokine