title: Granulocyte transfusion therapy in paediatric patients with severe neutropenic infection.
abstract: The data of 10 children who developed 13 high-risk febrile neutropenia with/without microbiologically documented severe infection, while being treated for a hematologic disorder were investigated retrospectively. The 24th hour post-transfusion neutrophil and platelet counts increased significantly, compared to the baseline values (p=0.034, p=0.025). Except three granulocyte transfusions (GTs) after which oliguria and/or mild respiratory distress developed, the transfusions were well tolerated. The clinical response, hematologic response and infection related mortality rates were 69.2%, 53.8% and 30.8%, respectively. Although our study includes limited number of patients, we can conclude that GT seems beneficial for children with severe sepsis during neutropenia.
authors.affiliation: Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital of the Ministry of Health, Department of Pediatric Hematology, Ankara, Turkey. sedaozturkmen@yahoo.com
authors.forename: Seda
authors.initials: S
authors.lastname: Oztürkmen
authors.forename: Fevzi
authors.initials: F
authors.lastname: Altuntaş
authors.forename: Lale
authors.initials: L
authors.lastname: Olcay
mesh_terms: D000293:Adolescent; D016913:Blood Component Transfusion / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006098:Granulocytes / Q000166:cytology*; D006402:Hematologic Diseases / Q000628:therapy; D006801:Humans; D007239:Infections / Q000628:therapy*; D017708:Leukocyte Transfusion / Q000379:methods*; D008297:Male; D009503:Neutropenia / Q000628:therapy*; D009504:Neutrophils / Q000166:cytology; D010976:Platelet Count; D013997:Time Factors; D016896:Treatment Outcome