title: Trimerization of β-cyclodextrin through the click reaction.
abstract: Triprop-2-ynyl benzene-1,3,5-tricarboxylate (A) is synthesized by the reaction of 1,3,5-benzenetricarbonyl trichloride with propargyl alcohol and (A) is clicked with mono-6-deoxy-6-azido-β-cyclodextrin (N3-β-CD) in the presence of copper(I) bromide catalyst. N3-β-CD has been prepared from β-cyclodextrin (β-CD) on treatment with toluenesulfonyl chloride (TsCl) and then with sodium azide (NaN3) in two consecutive steps. Further trimer of β-CD is characterized by (1)H NMR and FTIR studies. Solubility of β-cyclodextrin (β-CD) in water can be increased by increasing the number of alcoholic OH functionalities and hydrophobic cavities in a molecule by the trimerization of β-CD.
authors.affiliation: Department of Chemistry, Banaras Hindu University, Varanasi 221005, U.P., India. kranthibhu@gmail.com
authors.forename: Kranthikumar
authors.initials: K
authors.lastname: Tungala
authors.forename: P
authors.initials: P
authors.lastname: Adhikary
authors.forename: S
authors.initials: S
authors.lastname: Krishnamoorthi
mesh_terms: D057930:Click Chemistry; D009682:Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D014233:Tricarboxylic Acids / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D014233:Tricarboxylic Acids; D047392:beta-Cyclodextrins; C031215:betadex