title: Multidisciplinary quality improvement initiative to reduce ventilator-associated tracheobronchitis in the PICU.
abstract: OBJECTIVE
  To test the hypothesis that successful implementation of a care bundle designed to prevent nosocomial airway infection will be associated with decreased incidence of ventilator-associated tracheobronchitis.
  
  
  METHODS
  Prospective pre- and post interventional.
  
  
  METHODS
  PICU at an academic medical center
  
  
  METHODS
  : All patients admitted to the PICU who received invasive mechanical ventilation for greater than or equal to 48 hours between March 1, 2009, and December 31, 2011.
  
  
  METHODS
  Multidisciplinary, unit wide implementation of an evidence-based care bundle to prevent ventilator-associated airway infection.
  
  
  RESULTS
  There were 725 patients included in the analysis (338 patients preintervention and 387 patients postintervention). Baseline ventilator-associated tracheobronchitis rate in the preintervention period was 3.9 cases per 1,000 ventilator days compared with 1.8 cases per 1,000 ventilator days postintervention (p = 0.04, Fisher exact test). Compared with patients without ventilator-associated tracheobronchitis or ventilator-associated pneumonia, patients with ventilator-associated tracheobronchitis had fewer ventilator-free days in 28 days (4.9 vs 22; p < 0.0001, Mann-Whitney U test) and fewer ICU-free days in 28 days (0.5 vs 19; p < 0.0001, Mann-Whitney U test). These relationships remained significant after adjusting for covariates by multivariable linear regression.
  
  
  CONCLUSIONS
  Successful implementation of a care bundle to prevent ventilator-associated infection was associated with decreased incidence of ventilator-associated tracheobronchitis. Development of ventilator-associated tracheobronchitis was independently associated with adverse outcomes in our cohort of pediatric ICU patients.
authors.affiliation: Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. jennifer.muszynski@nationwidechildrens.org
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Muszynski
authors.forename: James
authors.initials: J
authors.lastname: Sartori
authors.forename: Lisa
authors.initials: L
authors.lastname: Steele
authors.forename: Randall
authors.initials: R
authors.lastname: Frost
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Nadeem
authors.initials: N
authors.lastname: Khan
authors.forename: Anthony
authors.initials: A
authors.lastname: Lee
authors.forename: Ada
authors.initials: A
authors.lastname: Lin
authors.forename: Mark W
authors.initials: MW
authors.lastname: Hall
authors.forename: Onsy
authors.initials: O
authors.lastname: Ayad
mesh_terms: D000046:Academic Medical Centers; D001991:Bronchitis / Q000209:etiology* / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000401:mortality / Q000517:prevention & control*; D019317:Evidence-Based Medicine; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric / Q000458:organization & administration* / Q000706:statistics & numerical data; D016014:Linear Models; D008297:Male; D015397:Program Evaluation; D011446:Prospective Studies; D058996:Quality Improvement / Q000458:organization & administration*; D014136:Tracheitis / Q000209:etiology* / Q000517:prevention & control; D012122:Ventilators, Mechanical / Q000009:adverse effects*