title: Lack of association between dendritic cell nuclear protein-1 gene and major depressive disorder in the Han Chinese population.
abstract: OBJECTIVE
  Dendritic cell nuclear protein-1 (DCNP1) has been associated with major depressive disorder (MDD) based on analysis of a population of patients in the United Kingdom. In the present study we have investigated a possible role of DCNP in MDD in the Han Chinese population, including a meta-analysis of different ethnic populations.
  
  
  METHODS
  Eight single nucleotide polymorphisms (SNPs) spanning the entire DCNP1 were carefully selected, genotyped and used for the SNP and haplotype analyses in 574 patients with MDD and 642 healthy controls. Considering the potential genetic association difference across different ethnic populations, we further conducted a meta-analysis for Chinese and European populations.
  
  
  RESULTS
  rs10061623 showed initial association with MDD in females in the allele analysis (p-value: 0.043). However, this association did not remain significant after Bonferroni correction to adjust for multiple comparisons (corrected p-value: 0.344). Other single-marker and haplotype analyses did not reveal any significant differences between patients and controls. The SNP (rs12520799), positive in the original UK study, gave negative results in all our analyses. The meta-analysis results of rs12520799 also suggested possible negative association between this SNP and MDD in the Han Chinese population.
  
  
  CONCLUSIONS
  In the Han Chinese population, common DCNP1 polymorphisms are unlikely to be important in the genetic susceptibility to MDD.
authors.affiliation: Department of Neurobiology, Beijing Key Laboratory of Major Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Hua
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: Yang
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Dabao
authors.initials: D
authors.lastname: Zhang
authors.forename: Chuanyue
authors.initials: C
authors.lastname: Wang
authors.forename: Zhi-Qing David
authors.initials: ZQ
authors.lastname: Xu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D044465:White People / Q000235:genetics / Q000523:psychology
chemical_list: C446761:DCANP1 protein, human; D009687:Nuclear Proteins
keywords: Chinese population; DCNP1; DSM-IV Axis I disorders-Clinical Version; Dendritic cell nuclear protein-1; GWAS; Genome-wide association; HDRS; HWE; Hamilton's depression Rating Scale; Haplotype study; Hardy-Weinberg equilibrium; LD; MDD; Major depressive disorder; NESDA-NTR; SCID-D-CV; SNP; SNPs; The Netherlands Study of Depression and Anxietyand the Netherlands Twin Registry; UK; United Kingdom; linkage disequilibrium; single nucleotide polymorphism