title: Uniquely different PVA-xanthan gum irradiated membranes as transdermal diltiazem delivery device.
abstract: This paper reports interesting differences between physical and mechanical properties of various membranes prepared from high and low molecular weight poly (vinyl alcohol) (PVA) and xanthan gum (XG) blends irradiated under low dose electron beam. The membranes were designed for sustained delivery of diltiazem hydrochloride through skin. Electron beam irradiation produced crosslinks and turned PVA into crystalline phase from its amorphous organization in the unirradiated state. PVA crystals were fibrillar at low XG content (1 wt.%) when the molecular weight was high while similar orientation at higher XG content (5 wt.%) when the molecular weight was low. Low molecular weight PVA-XG membranes showed equivalent physical properties under dry condition but wet-mechanical properties were superior for high molecular weight PVA-XG hybrids. Both of them showed slow and sustained diltiazem release but the later induced slightly slower release despite low drug encapsulation efficiency due to its better wet mechanical strength.
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Calcutta 700009, India.
authors.forename: Tridib
authors.initials: T
authors.lastname: Bhunia
authors.forename: Arindam
authors.initials: A
authors.lastname: Giri
authors.forename: Tanbir
authors.initials: T
authors.lastname: Nasim
authors.forename: Dipankar
authors.initials: D
authors.lastname: Chattopadhyay
authors.forename: Abhijit
authors.initials: A
authors.lastname: Bandyopadhyay
mesh_terms: D000279:Administration, Cutaneous; D002152:Calorimetry, Differential Scanning; D004110:Diltiazem / Q000737:chemistry*; D016503:Drug Delivery Systems; D004583:Electrons; D008567:Membranes, Artificial; D018625:Microscopy, Atomic Force; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength; D014961:X-Ray Diffraction
chemical_list: D008567:Membranes, Artificial; D011135:Polysaccharides, Bacterial; D011142:Polyvinyl Alcohol; D004110:Diltiazem; C002563:xanthan gum