title: The management of hypertension for an acute stroke: what is the blood pressure goal?
abstract: Stroke is the 4th leading cause of death in the US and a leading cause of disability among adults. Stroke is broadly classified into ischemic and hemorrhagic subtypes. Although the pathogenesis may differ between ischemic and hemorrhagic stroke subtypes, a unifying feature is that hypertension is a major risk factor for most ischemic and hemorrhagic strokes. Prevention of first and recurrent stroke is substantially dependent on blood pressure control. There is controversy about blood pressure management in acute stroke. In this review we discuss controversies about and guidelines for management of blood pressure in acute stroke. We subdivide our discussion to address important questions about acute blood pressure management in ischemic stroke, intraparenchymal hemorrhage, and subarachnoid hemorrhage. In addition, we address BP control recommendations when tissue plasminogen activator administration is being contemplated for treatment of acute ischemic stroke.
authors.affiliation: Hauenstein Neuroscience Center, Saint Mary's Health Care, Translational Science & Molecular Medicine, Michigan State University College of Human Medicine, 220 Cherry Street SE H 3037, Grand Rapids, MI, USA. pgorelic@trinity-health.org
authors.forename: Philip B
authors.initials: PB
authors.lastname: Gorelick
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Aiyagari
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination; D002545:Brain Ischemia / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D019317:Evidence-Based Medicine; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D020300:Intracranial Hemorrhages / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D007427:Intracranial Pressure; D008297:Male; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents