title: Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling.
abstract: We herein report on the pharmacophore determination of the ERK docking domain inhibitor (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione, which has led to the discovery of compounds with greater selectivities for inhibiting the proliferation of melanoma cells containing active ERK signaling.
authors.affiliation: Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N Pine St., Baltimore, MD 21201, USA.
authors.forename: Kwan-Young
authors.initials: KY
authors.lastname: Jung
authors.forename: Ramin
authors.initials: R
authors.lastname: Samadani
authors.forename: Jay
authors.initials: J
authors.lastname: Chauhan
authors.forename: Kerrick
authors.initials: K
authors.lastname: Nevels
authors.forename: Jeremy L
authors.initials: JL
authors.lastname: Yap
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Shilpa
authors.initials: S
authors.lastname: Worlikar
authors.forename: Maryanna E
authors.initials: ME
authors.lastname: Lanning
authors.forename: Lijia
authors.initials: L
authors.lastname: Chen
authors.forename: Mary
authors.initials: M
authors.lastname: Ensey
authors.forename: Sagar
authors.initials: S
authors.lastname: Shukla
authors.forename: Rosene
authors.initials: R
authors.lastname: Salmo
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Heinzl
authors.forename: Caryn
authors.initials: C
authors.lastname: Gordon
authors.forename: Troy
authors.initials: T
authors.lastname: Dukes
authors.forename: Alexander D
authors.initials: AD
authors.lastname: MacKerell
authors.forename: Paul
authors.initials: P
authors.lastname: Shapiro
authors.forename: Steven
authors.initials: S
authors.lastname: Fletcher
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D020935:MAP Kinase Signaling System / Q000187:drug effects; D008545:Melanoma / Q000188:drug therapy* / Q000201:enzymology; D013329:Structure-Activity Relationship; D045162:Thiazolidinediones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C546148:3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione; D000970:Antineoplastic Agents; D045162:Thiazolidinediones; D048049:Extracellular Signal-Regulated MAP Kinases