title: Appetite suppressing pregnane glycosides from the roots of Cynanchum auriculatum.
abstract: In the search for plant alternatives to Hoodia gordonii containing P57, a pregnane glycoside with potential appetite suppressant effect, the roots of Cynanchum auriculatum were investigated. As a result, 15 pregnane glycosides including nine never previously reported were isolated. Their structures were elucidated on the basis of extensive spectroscopic analyses and chemical methods. Appetite suppressant effect and body weight loss were observed when tested with the most abundant pregnane glycoside, wilfoside K1N, in an in vivo test with rats.
authors.affiliation: Department of Natural Products Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China.
authors.forename: Shuangzhu
authors.initials: S
authors.lastname: Liu
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Luoyi
authors.initials: L
authors.lastname: Wang
authors.forename: Hongmin
authors.initials: H
authors.lastname: Wang
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031105:Cynanchum / Q000737:chemistry*; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D011278:Pregnanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D001067:Appetite Depressants; D006027:Glycosides; D010936:Plant Extracts; D011278:Pregnanes; C574437:pregnane glycoside
keywords: Appetite suppressant; Asclepiadaceae; Cynanchum auriculatum; Pregnane glycoside