title: Targeting thalamic tremor cells in deep brain stimulation for multiple sclerosis-induced complex tremor.
abstract: BACKGROUND
  Tremor is an important cause of disability in patients with multiple sclerosis (MS). It is an ongoing debate as to which brain region should be targeted in MS patients with complex tremors.
  
  
  METHODS
  Here, we describe our experience with targeting thalamic tremor cells in the ventro-intermediate/ventro-oralis posterior (Vim/Vop) region in a patient with MS related complex tremor. Intraoperative multiple-microelectrode recordings showed the existence of tremor cells. Test stimulation produced the best effect when performed at the regions where tremor cells were recorded. Postoperative examination revealed a substantial improvement of the tremor.
  
  
  CONCLUSIONS
  Our case observation reveals the existence of a neurophysiological target for deep brain stimulation (DBS) in MS related tremor.
authors.affiliation: Department of Neurosurgery, Ondokuz Mayis University, Samsun, Turkey ; Department of Neurosurgery and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Ersoy
authors.initials: E
authors.lastname: Kocabicak
authors.forename: Murat
authors.initials: M
authors.lastname: Terzi
authors.forename: Onur
authors.initials: O
authors.lastname: Alptekin
authors.forename: Yasin
authors.initials: Y
authors.lastname: Temel
keywords: Deep brain stimulation; multiple sclerosis; nucleus ventro-oralis posterior; thalamus; tremor cell; ventro-intermediate nucleus