title: The regulation of epidermal melanogenesis via cAMP and/or PKC signaling pathways: insights for the development of hypopigmenting agents.
abstract: Abnormal pigmentation, particularly hyperpigmentation, is major issue of concern for people with colored skin. Several hypopigmenting agents, which exert their action by inhibiting tyrosinase activity and/or transcription, have been used for treatment. However, results have been discouraging. To manage abnormal pigmentation properly, the mechanisms of melanogenesis should be understood. Endogenous and exogenous factors affect melanogenesis via intracellular machineries. cAMP and PKC are critical factors of important transduction pathways and cross-talk between them could amplify the melanogenic effect. Here, factors involved in melanogenesis regulation via cAMP and/or PKC pathways are reviewed with their action mechanisms.
authors.affiliation: Department of Dermatology, Dongguk University Seoul, Graduate School of Medicine, 814 Siksa-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-773, South Korea. lay5604@naver.com
authors.forename: Ai-Young
authors.initials: AY
authors.lastname: Lee
authors.forename: Minsoo
authors.initials: M
authors.lastname: Noh
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry; D000242:Cyclic AMP / Q000037:antagonists & inhibitors / Q000502:physiology*; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D006873:Hydroquinones / Q000008:administration & dosage / Q000737:chemistry; D008543:Melanins / Q000037:antagonists & inhibitors / Q000378:metabolism; D008544:Melanocytes / Q000187:drug effects / Q000378:metabolism*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000502:physiology*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000737:chemistry; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D014212:Tretinoin / Q000008:administration & dosage / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D000975:Antioxidants; D006873:Hydroquinones; D008543:Melanins; D011837:Radiation-Protective Agents; D014212:Tretinoin; D000242:Cyclic AMP; D011493:Protein Kinase C; C031927:hydroquinone