title: Beneficial effects of Allium sativum L. stem extract on lipid metabolism and antioxidant status in obese mice fed a high-fat diet.
abstract: BACKGROUND
  This study was designed to examine the potential health benefits of Allium sativum L. (garlic) stem extract (ASSE) on obesity and related disorders in high-fat diet-induced obese mice. Obese mice were orally administered ASSE at doses of 100, 250 and 500 mg kg(-1) body weight day(-1) for 4 weeks.
  
  
  RESULTS
  Consumption of ASSE significantly suppressed body weight gain and white adipose tissue (WAT) weight regardless of daily food intake. Obese mice fed ASSE also exhibited a significant decrease in WAT cell size. The decreased level of adiponectin and increased level of leptin in obese mice reverted to near normal mice levels in ASSE-treated mice. ASSE administration significantly improved lipid parameters of the serum and liver and inhibited fat accumulation in the liver by modulating the activities of hepatic lipid-regulating enzymes in obese mice. Administration of ASSE also led to significant increases in antioxidant enzymes and suppressed glutathione depletion and lipid peroxidation in hepatic tissue.
  
  
  CONCLUSIONS
  These results suggest that ASSE may ameliorate obesity, insulin resistance and oxidative damage in high-fat diet-induced obese mice.
authors.affiliation: Department of Agrofood Resources, National Academy of Agricultural Science, Rural Development Administration, Suwon, 441-853, Republic of Korea.
authors.forename: Inhye
authors.initials: I
authors.lastname: Kim
authors.forename: Haeng-Ran
authors.initials: HR
authors.lastname: Kim
authors.forename: Jae-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Ae-Son
authors.initials: AS
authors.lastname: Om
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001786:Blood Glucose; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects; D005243:Feces / Q000737:chemistry; D005737:Garlic / Q000737:chemistry*; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000737:chemistry; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*; D011897:Random Allocation
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D004041:Dietary Fats; D008055:Lipids; D010936:Plant Extracts
keywords: Allium sativum L. stem; antiobesity; antioxidant enzyme; lipid lowering