title: INstruct: a database of high-quality 3D structurally resolved protein interactome networks.
abstract: INstruct is a database of high-quality, 3D, structurally resolved protein interactome networks in human and six model organisms. INstruct combines the scale of available high-quality binary protein interaction data with the specificity of atomic-resolution structural information derived from co-crystal evidence using a tested interaction interface inference method. Its web interface is designed to allow for flexible search based on standard and organism-specific protein and gene-naming conventions, visualization of protein architecture highlighting interaction interfaces and viewing and downloading custom 3D structurally resolved interactome datasets.
  
  
  BACKGROUND
  INstruct is freely available on the web at http://instruct.yulab.org with all major browsers supported.
authors.affiliation: Department of Biological Statistics and Computational Biology and Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Meyer
authors.forename: Jishnu
authors.initials: J
authors.lastname: Das
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Wang
authors.forename: Haiyuan
authors.initials: H
authors.lastname: Yu
mesh_terms: D000818:Animals; D030562:Databases, Protein; D006801:Humans; D051379:Mice; D054730:Protein Interaction Domains and Motifs; D025941:Protein Interaction Mapping / Q000379:methods*