title: LILRA3 is associated with benign prostatic hyperplasia risk in a Chinese Population.
abstract: A recent prostate cancer (PCa) genome-wide association study (GWAS) identified rs103294, a single nucleotide polymorphism (SNP) located on LILRA3, a key component in the regulation of inflammatory inhibition, to be significantly associated with PCa risk in a Chinese population. Because inflammation may be a common etiological risk factor between PCa and benign prostatic hyperplasia (BPH), the current study was conducted to investigate the association of rs103294 with BPH risk. rs103294 was genotyped in a Chinese population of 426 BPH cases and 1,008 controls from Xinhua Hospital in Shanghai, China. Association between rs103294, BPH risk and clinicopathological traits were tested with adjustment for age. rs103294 was significantly associated with BPH risk with a p-value of 0.0067. Individuals with risk allele "C" had increased risk for BPH (OR = 1.34, 95% CI: 1.09-1.66). Stratified analysis revealed a stronger association risk for younger patients who are below 72 years old (OR = 1.51, 95% CI: 1.06-2.16). Our study represents the first effort to demonstrate that LILRA3 gene is significantly associated with BPH risk in a Chinese population. Our results support a common role of inflammation in the development of PCa and BPH. Additional studies are needed to further evaluate our results.
authors.affiliation: Department of Urology, Xinhua Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200092, China. jasonqi@sh163.net.
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiao
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Gu
authors.forename: Sha
authors.initials: S
authors.lastname: Tao
authors.forename: Lu
authors.initials: L
authors.lastname: Tian
authors.forename: Rong
authors.initials: R
authors.lastname: Na
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Kang
authors.forename: Siqun L
authors.initials: SL
authors.lastname: Zheng
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
authors.forename: Jielin
authors.initials: J
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Qi
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D002681:China; D003710:Demography; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009929:Organ Size; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011470:Prostatic Hyperplasia / Q000235:genetics* / Q000473:pathology; D011971:Receptors, Immunologic / Q000235:genetics*; D012307:Risk Factors
chemical_list: C530062:LILRA3 protein, human; D011971:Receptors, Immunologic