title: Two new vinblastine-type N-oxide alkaloids from Catharanthus roseus.
abstract: Two new vinblastine-type N-oxide alkaloids, 17-desacetoxyvinblastine N'b-oxide (1) and 20'-deoxyvinblastine N'b-oxide (2), were isolated from the leaves of Catharanthus roseus. The structures of 1 and 2 were established by the analysis of their nuclear magnetic resonance and HR-ESI-MS spectroscopic data. All alkaloids were evaluated for their cytotoxic activities against the human hepatocellular carcinoma (HepG2) cell line, human colorectal carcinoma (Lovo) cell line and human breast carcinoma (MCF-7) cell line by the MTT method in vitro, respectively. The results showed that cytotoxic activities of alkaloids 1 and 2 exhibited moderate inhibitory activity on the proliferation of three cancer cells.
authors.affiliation: a Department of Pharmacology , Institute of Clinical Medical Sciences, China-Japan Friendship Hospital , Beijing , 100029 , People's Republic of China.
authors.forename: Wei-Ku
authors.initials: WK
authors.lastname: Zhang
authors.forename: Jie-Kun
authors.initials: JK
authors.lastname: Xu
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Tian
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Xu-Zhi
authors.initials: XZ
authors.lastname: Xiao
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D030008:Catharanthus / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D013778:Tetrazolium Salts; D013844:Thiazoles; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C000589073:17-desacetoxyvinblastine N-oxide; C000589074:20'-deoxyvinblastine N-oxide; D013778:Tetrazolium Salts; D013844:Thiazoles; D014747:Vinblastine; C022616:thiazolyl blue