title: Trabecular bone structure analysis of the spine using clinical MDCT: can it predict vertebral bone strength?
abstract: Recent technical improvements have made it possible to determine trabecular bone structure parameters of the spine using clinical multi-detector computed tomography (MDCT). Therefore, the purpose of this study was to analyze trabecular bone structure parameters obtained from clinical MDCT in relation to high resolution peripheral quantitative computed tomography (HR-pQCT) as a standard of reference and to investigate whether clinical MDCT can predict vertebral bone strength. Fourteen functional spinal segment units between T7 and L3 were harvested from 14 formalin-fixed human cadavers (11 women and 3 men; age 84 ± 10 years). All functional spinal segment units were examined using HR-pQCT (isotropic voxel size of 41 μm(3)) and a clinical whole-body MDCT (interpolated voxel size of 146 × 146 × 300 μm(3)). Trabecular bone structure analyses (histomorphometric and texture measures) were performed in the HR-pQCT as well as MDCT images. Vertebral failure load (FL) of the functional spinal segment units was determined in an uniaxial biomechanical test. The HR-pQCT and MDCT derived trabecular bone structure parameters showed correlations ranging from r = 0.60 to r = 0.90 (p < 0.05). Correlations between trabecular bone structure parameters and FL amounted up to r = 0.86 (p < 0.05) using the HR-pQCT images, and up to r = 0.79 (p < 0.05) using the MDCT images. Correlation coefficients of FL versus trabecular bone structure parameters obtained with HR-pQCT and MDCT were not significantly different (p > 0.05). In this cadaver model, the spatial resolution of clinically available whole-body MDCT scanners was suitable for trabecular bone structure analysis of the spine and to predict vertebral bone strength.
authors.affiliation: Institut für Radiologie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany, thbaum@gmx.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Baum
authors.forename: Martin
authors.initials: M
authors.lastname: Gräbeldinger
authors.forename: Christoph
authors.initials: C
authors.lastname: Räth
authors.forename: Eduardo Grande
authors.initials: EG
authors.lastname: Garcia
authors.forename: Rainer
authors.initials: R
authors.lastname: Burgkart
authors.forename: Janina M
authors.initials: JM
authors.lastname: Patsch
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Rummeny
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Link
authors.forename: Jan S
authors.initials: JS
authors.lastname: Bauer
mesh_terms: D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D061330:Multidetector Computed Tomography; D013131:Spine / Q000000981:diagnostic imaging* / Q000502:physiology