title: Correlation of thyroid fine-needle aspiration with final histopathology: a case series.
abstract: OBJECTIVE
  The aim of this study was to evaluate the correlation between preoperative thyroid fine-needle aspiration result and final histopathology in patients with thyroid nodules.
  
  
  METHODS
  The medical records of 298 patients (mean age, 47.7±12.3 years; 79.5% females) who underwent fine-needle aspiration for thyroid nodules and who were operated and have final pathological diagnosis were retrospectively reviewed. For reporting fine-needle aspiration specimen pathology, the Bethesda thyroid fine-needle aspiration classification was used. Tyroglobulin (Tg) and anti-Tg and anti-thyroid peroxidase (anti-TPO) antibody levels were determined preoperatively.
  
  
  RESULTS
  Thyroid nodules were non-diagnostic, benign or atypia (Bethesda groups 1-3) in 76.8% of patients; and follicular neoplasm, suspicious for malignancy or malignant (Bethesda groups 4-6) in 23.1% of patients. Final pathology of surgery specimen was most commonly nodular goiter (36.6%) and papillary carcinoma (35.6%). Nodular goiter was significantly more prevalent in Bethesda 1 group while papillary carcinoma was more common in Bethesda 3 group (P<0.05). Tg level is significantly higher in the nodular goiter group (90.49±126.93 ng/mL), while anti-Tg and anti-TPO levels are significantly higher in the lymphocytic thyroiditis goiter group (229.77±494.42 U/mL and 282.86±360.77 U/mL, respectively) than the other pathology groups (P<0.05 for all).
  
  
  CONCLUSIONS
  Papillary carcinoma is more common in Bethesda thyroid fine-needle aspiration classification 3 group. Therefore, preoperative fine-needle aspiration for thyroid nodules is predictive of final pathology and should be applied for diagnosis and follow-up.
authors.affiliation: Department of General Surgery, Atatürk Research and Training Hospital , Ankara, Turkey. gurkandumlu@gmail.com
authors.forename: E
authors.initials: E
authors.lastname: Gürkan Dumlu
authors.forename: G
authors.initials: G
authors.lastname: Kiyak
authors.forename: B
authors.initials: B
authors.lastname: Bozkurt
authors.forename: M
authors.initials: M
authors.lastname: Tokaç
authors.forename: B
authors.initials: B
authors.lastname: Polat
authors.forename: B
authors.initials: B
authors.lastname: Cakir
authors.forename: G
authors.initials: G
authors.lastname: Güler
authors.forename: M
authors.initials: M
authors.lastname: Kiliç
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D000236:Adenoma / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D044963:Biopsy, Fine-Needle / Q000706:statistics & numerical data; D002291:Carcinoma, Papillary / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D054459:Elasticity Imaging Techniques; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006044:Goiter, Nodular / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013954:Thyroglobulin / Q000097:blood; D013959:Thyroid Diseases / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013964:Thyroid Neoplasms / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D016606:Thyroid Nodule / Q000097:blood / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy / Q000706:statistics & numerical data; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis / Q000473:pathology
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; C056626:thyroid microsomal antibodies; D013954:Thyroglobulin