title: Simplified methods of topical fluoride administration: effects in individuals with hyposalivation.
abstract: The aim was to compare fluoride (F) levels in individuals with normal salivary secretion and hyposalivation in connection with their use of F solutions and toothpaste. Seven individuals with normal salivation and nine with hyposalivation rinsed with 0.2% NaF solution for 1 minute. In addition, individuals with hyposalivation performed the following: (i) 0.2% NaF rinsing for 20 seconds, (ii) rubbing oral mucosa with a swab soaked with 0.2% NaF solution, and (iii) brushing with 5,000 ppm F (1.1% NaF) toothpaste. Subjects characterized by hyposalivation reached approximately five times higher peak values of F concentrations in saliva after 1 minute rinsing with the F solution and higher area under the curve (AUC) values. The simplified methods exhibited the same AUC values as did 1 minute of rinsing. Brushing with 5,000 ppm F toothpaste resulted in higher AUC values than did the simplified methods. The F concentrations reached higher levels in individuals with hyposalivation compared to those with normal salivation. The simplified methods tested showed similar effects as conventional methods.
authors.affiliation: Public Dental Health, Uppsala County Council, Uppsala, Sweden. pia.gabre@lul.se
authors.forename: Pia
authors.initials: P
authors.lastname: Gabre
authors.forename: Ulla
authors.initials: U
authors.lastname: Moberg Sköld
authors.forename: Dowen
authors.initials: D
authors.lastname: Birkhed
mesh_terms: D000278:Administration, Buccal; D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D002327:Cariostatic Agents / Q000008:administration & dosage*; D016022:Case-Control Studies; D005460:Fluorides, Topical / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D009067:Mouthwashes / Q000008:administration & dosage* / Q000737:chemistry; D012463:Saliva / Q000737:chemistry / Q000378:metabolism; D012636:Secretory Rate; D012969:Sodium Fluoride / Q000008:administration & dosage*; D018709:Statistics, Nonparametric; D013997:Time Factors; D014099:Toothbrushing; D014100:Toothpastes / Q000008:administration & dosage* / Q000737:chemistry; D014987:Xerostomia / Q000503:physiopathology*
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D009067:Mouthwashes; D014100:Toothpastes; D012969:Sodium Fluoride