title: Gas-phase fragmentation of oligoproline peptide ions lacking easily mobilizable protons.
abstract: The fragmentation of peptides containing quaternary ammonium group, but lacking easily mobilizable protons, was examined with the aid of deuterium-labeled analogs and quantum-chemical modeling. The fragmentation of oligoproline containing quaternary ammonium group involves the mobilization of hydrogens localized at α- and γ- or δ-carbon atoms in the pyrrolidine ring of proline. The study of the dissociation pattern highlights the unusual proline residue behavior during MS/MS experiments of peptides.
authors.affiliation: Faculty of Chemistry, University of Wrocław, Wrocław, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Rudowska
authors.forename: Robert
authors.initials: R
authors.lastname: Wieczorek
authors.forename: Alicja
authors.initials: A
authors.lastname: Kluczyk
authors.forename: Piotr
authors.initials: P
authors.lastname: Stefanowicz
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Szewczuk
mesh_terms: D003903:Deuterium; D005740:Gases / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*; D011522:Protons; D053719:Tandem Mass Spectrometry
chemical_list: D005740:Gases; D007477:Ions; D009842:Oligopeptides; D011522:Protons; D011392:Proline; D003903:Deuterium