title: Roles for central leptin receptors in the control of meal size.
abstract: The adiposity hormone leptin has been implicated in the regulation of behavioral and metabolic controls of body weight. Leptin receptors are found in multiple peripheral and central tissues, particularly within hypothalamic and brainstem neuronal populations. Central leptinergic signaling acts as an indirect control to modulate the feeding inhibitory potency of the direct controls of meal size. Mouse models of neuronal leptin loss and gain of function have helped to identify and characterize how central leptin contributes to the central control of food intake.
authors.affiliation: Departments of Medicine & Neuroscience, Albert Einstein College of Medicine, Diabetes Research and Training Center, New York Obesity Research Center, USA.
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Schwartz
authors.forename: Anthony V
authors.initials: AV
authors.lastname: Azzara
authors.forename: Martica K
authors.initials: MK
authors.lastname: Heaner
mesh_terms: D050154:Adiposity / Q000502:physiology; D000818:Animals; D001835:Body Weight; D004435:Eating / Q000502:physiology; D005247:Feeding Behavior; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D062407:Meals; D023421:Models, Animal; D009765:Obesity / Q000378:metabolism; D064787:Portion Size; D054411:Receptors, Leptin / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D020738:Leptin; D054411:Receptors, Leptin
keywords: Brainstem; Food intake; Hypothalamus; LepRb; Leptin; Meal size