title: Synthesis, structure and anti-acetylcholinesterase activity of 12a-O-methyl territrem B.
abstract: 12a-0-methyl territrem B was synthesized from TRB by treatment with dimethyl sulfate in methanolic NaOH. The structure of 12a-0-methyl territrem B was elucidated by uv, ir nmr and mass spectra and it is 2.5 times more potent than TRB in inhibitory activity on electric eel acetylcholinesterase (E. C. 3.1.1.7.) (AChE).
authors.affiliation: Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan ROC.
authors.forename: P F
authors.initials: PF
authors.lastname: Chuo
authors.forename: C P
authors.initials: CP
authors.lastname: Ho