title: Studying the effect of antioxidants on cytogenetic manifestations of solvent exposure in the paint industry.
abstract: OBJECTIVE
  To investigate the antioxidant role in reversing cytogenetic changes caused by solvent exposure in paint industry.
  
  
  METHODS
  A prospective controlled clinical trial was performed on 39 workers exposed to solvents and 39 workers not exposed to solvents by supplying a mixture of antioxidant vitamins (A, C, E and selenium) and the after effects of such regimen were analyzed. Environmental monitoring was carried out for air concentrations of different solvents at workplace. Exposed group was cytogenetically tested before and after giving the mixture of antioxidant vitamins for 1 month duration.
  
  
  RESULTS
  Frequency of chromosomal aberrations (CAs) and the mean of sister chromatid exchanges (SCEs) were statistically significantly higher among exposed workers than among controls. After the supplementation of antioxidants, there was a statistically significant decrease in the frequency of CAs, and 88% abnormal levels of SCEs were back to normal levels.
  
  
  CONCLUSIONS
  Antioxidant supplementation decreases the frequency of CAs and SCEs among exposed workers.
authors.affiliation: Department of Industrial Medicine and Occupational Diseases, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Aamal
authors.initials: A
authors.lastname: El Safty
authors.affiliation: Department of Environmental and Occupational Medicine, National Research Center, Egypt.
authors.forename: Fateheya Mohamed
authors.initials: FM
authors.lastname: Metwally
authors.affiliation: Department of Industrial Medicine and Occupational Diseases, Faculty of Medicine, Cairo University, Egypt aishasamir@yahoo.com.
authors.forename: Aisha
authors.initials: A
authors.lastname: Mohammed Samir
authors.affiliation: Department of Environmental and Occupational Medicine, National Research Center, Egypt.
authors.forename: Amir
authors.initials: A
authors.lastname: ElShahawy
authors.affiliation: Department of Research on Children with Special Needs, National Research Center, Egypt.
authors.forename: Ehab Abdel
authors.initials: EA
authors.lastname: Raouf
mesh_terms: D000395:Air Pollutants, Occupational / Q000633:toxicity; D016902:Air Pollution, Indoor / Q000009:adverse effects; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D002869:Chromosome Aberrations / Q000139:chemically induced*; D019587:Dietary Supplements; D023801:Directly Observed Therapy; D004534:Egypt; D004784:Environmental Monitoring; D006801:Humans; D007281:Ink; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000032:analysis / Q000633:toxicity*; D009369:Neoplasms / Q000139:chemically induced / Q000235:genetics / Q000517:prevention & control; D016273:Occupational Exposure / Q000009:adverse effects*; D010150:Paint / Q000032:analysis / Q000633:toxicity*; D012643:Selenium / Q000627:therapeutic use; D012854:Sister Chromatid Exchange / Q000187:drug effects; D012997:Solvents / Q000032:analysis / Q000633:toxicity*; D014801:Vitamin A / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D000395:Air Pollutants, Occupational; D000975:Antioxidants; D009153:Mutagens; D012997:Solvents; D014801:Vitamin A; D014810:Vitamin E; D012643:Selenium; D001205:Ascorbic Acid
keywords: Organic solvents; antioxidants vitamins; cytogenetic damage; paint industry