title: Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice.
abstract: Intestinal plasma cells predominantly produce immunoglobulin (Ig) A, however, their functional diversity remains poorly characterized. Here we show that murine intestinal IgA plasma cells can be newly classified into two populations on the basis of CD11b expression, which cannot be discriminated by currently known criteria such as general plasma cell markers, B cell origin and T cell dependence. CD11b(+) IgA(+) plasma cells require the lymphoid structure of Peyer's patches, produce more IgA than CD11b(-) IgA(+) plasma cells, proliferate vigorously, and require microbial stimulation and IL-10 for their development and maintenance. These features allow CD11b(+) IgA(+) plasma cells to mediate early-phase antigen-specific intestinal IgA responses induced by oral immunization with protein antigen. These findings reveal the functional diversity of IgA(+) plasma cells in the murine intestine.
authors.affiliation: Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan. kunisawa@nibio.go.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Kunisawa
authors.forename: Masashi
authors.initials: M
authors.lastname: Gohda
authors.forename: Eri
authors.initials: E
authors.lastname: Hashimoto
authors.forename: Izumi
authors.initials: I
authors.lastname: Ishikawa
authors.forename: Morio
authors.initials: M
authors.lastname: Higuchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Goto
authors.forename: Casandra
authors.initials: C
authors.lastname: Panea
authors.forename: Ivaylo I
authors.initials: II
authors.lastname: Ivanov
authors.forename: Risa
authors.initials: R
authors.lastname: Sumiya
authors.forename: Lamichhane
authors.initials: L
authors.lastname: Aayam
authors.forename: Taichi
authors.initials: T
authors.lastname: Wake
authors.forename: So
authors.initials: S
authors.lastname: Tajiri
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kurashima
authors.forename: Shiori
authors.initials: S
authors.lastname: Shikata
authors.forename: Shizuo
authors.initials: S
authors.lastname: Akira
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kiyono
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D039481:CD11b Antigen / Q000378:metabolism*; D049109:Cell Proliferation; D007114:Immunization; D007070:Immunoglobulin A / Q000378:metabolism*; D016753:Interleukin-10 / Q000378:metabolism; D007422:Intestines / Q000166:cytology / Q000276:immunology* / Q000382:microbiology*; D051379:Mice; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology; D010950:Plasma Cells / Q000166:cytology / Q000276:immunology*
chemical_list: D039481:CD11b Antigen; D007070:Immunoglobulin A; D016753:Interleukin-10; D010047:Ovalbumin