title: The effect of diabetes mellitus and end-stage renal disease on the number of CD34+ cells in the blood.
abstract: The aim of this study was to investigate the effect of end-stage renal disease (ESRD) and diabetes mellitus (DM) on the number of stem cells in the peripheral blood. Sixty-two patients diagnosed with ESRD who had not received dialysis previously, 25 patients with a diagnosis of DM without nephropathy, and 21 healthy volunteers were included in the study. The group diagnosed with ESRD was divided into two groups. The first group (DM-CRD) consisted of 28 patients with DM who had developed chronic renal disease (CRD). The second group (NON-DM-CRD) consisted of 34 patients without DM who had CRD by etiology. The routine complete blood count, renal function, and number of CD34+ cells were determined for all of those involved in the study. The microalbumin/creatinine levels were measured, and glomerular filtration rates were calculated in all patients. The number of CD34+ cells was found to be significantly lower in the DM control group and DM-CRD group compared with the healthy group. No statistically significant difference was found between the NON-DM-CRD and the healthy control group. There was a moderate negative correlation between the ratio of microalbumin/creatinine and the number of CD34+ cells. A significant reduction in the number of CD34+ cells was shown in subjects with DM and ESRD caused by diabetic nephropathy.
authors.affiliation: Department of Hematology, Erciyes Stem Cell Transplantation Hospital, Faculty of Medicine, Erciyes University, 38039, Kayseri, Turkey. drcigdempala@gmail.com
authors.forename: Cigdem
authors.initials: C
authors.lastname: Pala
authors.forename: Ilker
authors.initials: I
authors.lastname: Altun
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Koker
authors.forename: Fatih
authors.initials: F
authors.lastname: Kurnaz
authors.forename: Serdar
authors.initials: S
authors.lastname: Sivgin
authors.forename: Ismail
authors.initials: I
authors.lastname: Koçyiğit
authors.forename: Fatih
authors.initials: F
authors.lastname: Tanrıverdi
authors.forename: Leylagul
authors.initials: L
authors.lastname: Kaynar
authors.forename: Ferhan
authors.initials: F
authors.lastname: Elmali
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cetin
authors.forename: Bülent
authors.initials: B
authors.lastname: Eser
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood* / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000453:epidemiology* / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged
chemical_list: D018952:Antigens, CD34; D015415:Biomarkers