title: Successfully treated pneumatosis cystoides intestinalis with pneumoperitoneum onset in a patient administered α-glucosidase inhibitor.
abstract: An 80-year-old woman, who had been administered α-glucosidase inhibitor for diabetes, was brought to the hospital with the sensation of abdominal fullness and pain. Abdominal computed tomography indicated pneumatosis cystoides intestinalis (PCI) in the small intestinal wall, with free air within the abdomen. A blood examination showed no increases in white blood cells or C-reactive protein level. The patient's condition improved with conservative therapy. PCI with pneumoperitoneum induced by α-glucosidase inhibitor is rare, with only 27 cases (excluding the present case) reported in Japan to date. In PCI with pneumoperitoneum, differentiation from gastrointestinal perforation is important and following the clinical symptoms over time is vital.
authors.affiliation: Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. stanabe114@yahoo.co.jp
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Tanabe
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shirakawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takehara
authors.forename: Naoaki
authors.initials: N
authors.lastname: Maeda
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Katsube
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ohara
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Sakurama
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Noma
authors.forename: Toshiyoshi
authors.initials: T
authors.lastname: Fujiwara
mesh_terms: D000284:Administration, Oral; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D011006:Pneumatosis Cystoides Intestinalis / Q000139:chemically induced* / Q000628:therapy; D011027:Pneumoperitoneum / Q000139:chemically induced* / Q000628:therapy
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents