title: Surface-imprinted core-shell Au nanoparticles for selective detection of bisphenol A based on surface-enhanced Raman scattering.
abstract: Surface-imprinted core-shell Au nanoparticles (AuNPs) were explored for the highly selective detection of bisphenol A (BPA) by surface-enhanced Raman scattering (SERS). A triethoxysilane-template complex (BPA-Si) was synthesized and then utilized to fabricate a molecularly imprinted polymer (MIP) layer on the AuNPs via a sol-gel process. The imprinted BPA molecules were removed by a simple thermal treatment to generated the imprint-removed material, MIP-ir-AuNPs, with the desired recognition sites that could selectively rebind the BPA molecules. The morphological and polymeric characteristics of MIP-ir-AuNPs were investigated by transmission electron microscopy and Fourier-transform infrared spectroscopy. The results demonstrated that the MIP-ir-AuNPs were fabricated with a 2 nm MIP shell layer within which abundant amine groups were generated. The rebinding kinetics study showed that the MIP-ir-AuNPs could reach the equilibrium adsorption for BPA within 10 min owning to the advantage of ultrathin core-shell nanostructure. Moreover, a linear relationship between SERS intensity and the concentration of BPA on the MIP-ir-AuNPs was observed in the range of 0.5-22.8 mg L(-1), with a detection limit of 0.12 mg L(-1) (blank±3×s.d.). When applied to SERS detection, the developed surface-imprinted core-shell MIP-ir-AuNPs could recognize BPA and prevent interference from the structural analogues such as hexafluorobisphenol A (BPAF) and diethylstilbestrol (DES). These results revealed that the proposed method displayed significant potential utility in rapid and selective detection of BPA in real samples.
authors.affiliation: State Key Laboratory of Bioreactor Engineering & Department of Chemistry, East China University of Science and Technology, Shanghai 200237, PR China.
authors.forename: Jin-Qun
authors.initials: JQ
authors.lastname: Xue
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Li
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Qu
authors.forename: Yi-Tao
authors.initials: YT
authors.lastname: Long
mesh_terms: D001559:Benzhydryl Compounds / Q000032:analysis*; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D060766:Drinking Water / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D054802:Molecular Imprinting; D015394:Molecular Structure; D010636:Phenols / Q000032:analysis*; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D013499:Surface Properties; D013997:Time Factors; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D060766:Drinking Water; D006046:Gold; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds