title: [Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant gliomas--a new treatment modality].
abstract: 5-aminolevulinic acid (ALA) is a precursor of haemoglobin which leads to the synthesis of porphyrins in malignant gliomas which then appears with red fluorescence under blue light. In the literature we see that there is class Ib evidence that 5-ALA guided surgery significantly increases the radicalism of surgery and gives rise to a marked improvement in 6-month progression-free survival and that there is now class II evidence confirming the value of maximal cytoreductive surgery. Furthermore, existing class II evidence indicates that there is a synergistic effect between aggressive cytoreductive surgery and radiochemotherapy.
authors.affiliation: Neurokirurgisk Afdeling, Aarhus Universitetshospital, Aalborg Sygehus Syd, Ny Kastetvej 32, 9000 Aalborg, Denmark. cortnumx@hotmail.com
authors.forename: Søren
authors.initials: S
authors.lastname: Cortnum
authors.forename: Rene
authors.initials: R
authors.lastname: Laursen
mesh_terms: D000622:Aminolevulinic Acid; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D019317:Evidence-Based Medicine; D005456:Fluorescent Dyes; D005910:Glioma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D019635:Neurosurgical Procedures / Q000379:methods; D017319:Photosensitizing Agents; D016896:Treatment Outcome
chemical_list: D005456:Fluorescent Dyes; D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid