title: Differential significance of plasma visfatin concentrations according to adiposity in children and adolescents.
abstract: OBJECTIVE
  Visfatin is an adipocytokine predominantly expressed in visceral adipose tissue. We examined the relationship between plasma visfatin concentrations and anthropometric and metabolic parameters in children and adolescents, who are relatively less influenced by the effects of accompanying disease.
  
  
  METHODS
  We studied 135 children and adolescents (8-16 years old). Plasma glucose, insulin, lipid profile, visfatin and other adipocytokine levels were measured. CT scans were performed to evaluate the distribution of abdominal fat. We analyzed the relationship between circulating visfatin levels and anthropometric and metabolic parameters according to central adiposity (total abdominal fat by CT scan).
  
  
  RESULTS
  In the lower-adiposity group, plasma visfatin concentrations were significantly correlated with total abdominal fat, visceral fat, subcutaneous abdominal fat, plasma triglyceride level and homeostasis model assessment of insulin resistance (HOMA-IR). In a multiple linear regression analysis, visceral fat and triglycerides were independently associated with plasma visfatin levels. In the higher-adiposity group, plasma visfatin concentrations were not correlated with visceral fat or HOMA-IR but were significantly correlated with circulating interleukin-6 levels.
  
  
  CONCLUSIONS
  These data suggest that the relationship between plasma visfatin concentrations and metabolic parameters differs according to central adiposity and that plasma visfatin concentrations are correlated with visceral fat and triglyceride levels, especially in children and adolescents with lower adiposity.
authors.affiliation: Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Hae Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Park
authors.forename: Yong Jun
authors.initials: YJ
authors.lastname: Choi
authors.forename: Seung Jin
authors.initials: SJ
authors.lastname: Han
authors.forename: Kwan Woo
authors.initials: KW
authors.lastname: Lee
authors.forename: Dae Jung
authors.initials: DJ
authors.lastname: Kim
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D050152:Intra-Abdominal Fat / Q000378:metabolism; D008055:Lipids / Q000097:blood; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D009765:Obesity / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D015850:Interleukin-6; D008055:Lipids; D014280:Triglycerides; D054409:Nicotinamide Phosphoribosyltransferase