title: RNA binding and inhibition of primer extension by a Ru(III)/Pt(II) metal complex.
abstract: AH197, a trinuclear Ru(III)/Pt(II) metal complex, is strikingly more effective than the hallmark anticancer drug cisplatin and the Ru(III) clinical candidate NAMI-A in its binding to RNA and inhibition of primer DNA synthesis. Heteromultinuclear complexes could potentially serve as far better chemotherapeutics than mononuclear complexes.
authors.affiliation: Department of Chemistry, Bard College, 30 Campus Road, Annandale-on-Hudson, NY 12504, USA. sjain@bard.edu
authors.forename: Swapan S
authors.initials: SS
authors.lastname: Jain
authors.forename: Craig M
authors.initials: CM
authors.lastname: Anderson
authors.forename: Francesca
authors.initials: F
authors.lastname: DiRienzo
authors.forename: Isabelle R
authors.initials: IR
authors.lastname: Taylor
authors.forename: Kyan
authors.initials: K
authors.lastname: Jain
authors.forename: Sumedha
authors.initials: S
authors.lastname: Guha
authors.forename: Nushrat
authors.initials: N
authors.lastname: Hoque
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000633:toxicity; D002945:Cisplatin / Q000737:chemistry / Q000633:toxicity; D056831:Coordination Complexes / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D017931:DNA Primers / Q000737:chemistry / Q000378:metabolism*; D004121:Dimethyl Sulfoxide / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism; D010984:Platinum / Q000737:chemistry*; D012313:RNA / Q000737:chemistry / Q000378:metabolism*; D012428:Ruthenium / Q000737:chemistry*; D017975:Ruthenium Compounds; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D017931:DNA Primers; D009942:Organometallic Compounds; D017975:Ruthenium Compounds; C113661:imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III); D010984:Platinum; D012313:RNA; D012428:Ruthenium; D002945:Cisplatin; D004121:Dimethyl Sulfoxide