title: Optimization of maghemite-loaded PLGA nanospheres for biomedical applications.
abstract: Magnetic nanoparticles have been proposed as interesting tools for biomedical purposes. One of their promising utilization is the MRI in which magnetic substances like maghemite are used in a nanometric size and encapsulated within locally biodegradable nanoparticles. In this work, maghemite has been obtained by a modified sol-gel method and encapsulated in polymer-based nanospheres. The nanospheres have been prepared by single emulsion evaporation method. The different parameters influencing the size, polydispersity index and zeta potential surface of nanospheres were investigated. The size of nanospheres was found to increase as the concentration of PLGA increases, but lower sizes were obtained for 3 min of sonication time and surfactant concentration of 1%. Zeta potential response of magnetic nanospheres towards pH variation was similar to that of maghemite-free nanospheres confirming the encapsulation of maghemite within PLGA nanospheres. The maghemite entrapment efficiency and maghemite content for nanospheres are 12% and 0.59% w/w respectively.
authors.affiliation: Departamento de Química, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900 Maringá-PR, Brazil. celafs@gmail.com
authors.forename: Marcela Fernandes
authors.initials: MF
authors.lastname: Silva
authors.forename: Ana Adelina
authors.initials: AA
authors.lastname: Winkler Hechenleitner
authors.forename: Daniela Martins Fernandes
authors.initials: DM
authors.lastname: de Oliveira
authors.forename: Maite
authors.initials: M
authors.lastname: Agüeros
authors.forename: Rebeca
authors.initials: R
authors.lastname: Peñalva
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Irache
authors.forename: Edgardo Alfonso Gómez
authors.initials: EA
authors.lastname: Pineda
mesh_terms: D004655:Emulsions; D005290:Ferric Compounds / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D060328:Magnetic Phenomena; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013010:Sonication
chemical_list: D004655:Emulsions; D005290:Ferric Compounds; C000499:ferric oxide; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid