title: Liver stiffness values in HIV-infected patients with isolated anti-hepatitis B core antibodies.
abstract: BACKGROUND
  Hepatitis B reactivation has been observed in HIV-infected patients with isolated anti-HBc. However, the impact of isolated anti-HBc on liver fibrosis is not known in this population.
  
  
  METHODS
  We investigated liver stiffness values (LSV) in a population of HIV-infected patients with isolated anti-HBc, and attempted to identify risk factors for high values.
  
  
  RESULTS
  Fifty-one out of 69 patients (74%) had low LSV (≤7.1 kPa). In univariate analysis, high LSV (>7.1 kPa) were associated with HCV coinfection, the duration of HIV infection, the duration of antiretroviral therapy and lipodystrophy. In age-adjusted multivariate analysis, HCV coinfection (OR 11.5; 95% CI, 3.0-62.9; P=0.001) and lipodystrophy (OR 4.6; 95% CI, 1.1-20.7; P=0.031) remained associated with high liver stiffness values.
  
  
  CONCLUSIONS
  Lipodystrophy was the only factor associated with high liver stiffness values in our population of HIV-infected patients with isolated anti-Hbc and extensive exposure to antiretroviral drugs active on HBV, apart from HCV coinfection Our study correlates to recent studies the results of which have shown that lipodystrophy, and more generally mitochondrial toxicity, was associated with advanced liver fibrosis in HIV/HCV co-infected patients.
authors.affiliation: Service des maladies infectieuses et tropicales, hôpital Tenon, 4, rue de la Chine, 75970 Paris cedex 20, France.
authors.forename: C
authors.initials: C
authors.lastname: Chakvetadze
authors.forename: F
authors.initials: F
authors.lastname: Bani-Sadr
authors.forename: F X
authors.initials: FX
authors.lastname: Lescure
authors.forename: C
authors.initials: C
authors.lastname: Fontaine
authors.forename: C
authors.initials: C
authors.lastname: Le Pendeven
authors.forename: P
authors.initials: P
authors.lastname: Bonnard
authors.forename: P
authors.initials: P
authors.lastname: Mariot
authors.forename: P
authors.initials: P
authors.lastname: Soussan
authors.forename: G
authors.initials: G
authors.lastname: Pialoux
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D001706:Biopsy; D060085:Coinfection; D004548:Elasticity; D054459:Elasticity Imaging Techniques; D005234:Fatty Liver / Q000209:etiology / Q000473:pathology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D039682:HIV-Associated Lipodystrophy Syndrome / Q000139:chemically induced / Q000150:complications / Q000473:pathology; D006510:Hepatitis B Antibodies / Q000097:blood* / Q000276:immunology; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D006515:Hepatitis B virus / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000150:complications / Q000276:immunology / Q000473:pathology*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000473:pathology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000187:drug effects / Q000473:pathology; D065626:Non-alcoholic Fatty Liver Disease; D014775:Virus Activation
chemical_list: D019380:Anti-HIV Agents; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens
keywords: Anticorps anti-HBc isolés; Fibroscan; HCV infection; HIV infection; Infection par le VIH; Isolated anti-hepatitis B core antibodies; Lipodystrophie; Lipodystrophy; Liver stiffness; Élasticité hépatique