title: Salicylic acid peel incorporating triethyl citrate and ethyl linoleate in the treatment of moderate acne: a new therapeutic approach.
abstract: BACKGROUND
  Acne affects many adolescents. Conventional therapy often results in side effects and poor adherence, and the treatment does not consider the psychological effect of acne on patients, which is comparable with that of disabling diseases.
  
  
  OBJECTIVE
  To evaluate the efficacy and tolerability of a peel (30% salicylic acid, triethyl citrate and ethyl linoleate) combined with a home therapy with three topical agents (triethyl citrate, ethyl linoleate and salicylic acid 0.5% cream, lotion) in moderate acne of the face.
  
  
  METHODS
  Prospective, observational, multicenter, open-label, postmarketing, phase IV study.
  
  
  METHODS
  Patients were assessed by comparing Global Acne Grading System (GAGS) score and total lesion count from 15 days before the first peel (T-15 ), after four salicylic peels (every 10 ± 2 days (T0 , T10 , T20 , T30 ), and 20 days after of the end of the study (T50 ). This treatment was associated to a home therapy.
  
  
  RESULTS
  Fifty-three patients completed the study. The average GAGS score fell 49% between T-15 and T50 (p < .001). No patient withdrew for adverse events.
  
  
  CONCLUSIONS
  This therapy was effective and well-tolerated in all cases. Chemo-exfoliation sessions ensured the continuous monitoring of clinical results and improved patient quality of life.
authors.affiliation: Division of Dermatology, Department of Internal Medicine, Aging, and Nephrologic Diseases, Sant'Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Raone
authors.forename: Stefano
authors.initials: S
authors.lastname: Veraldi
authors.forename: Roberta
authors.initials: R
authors.lastname: Raboni
authors.forename: Marco
authors.initials: M
authors.lastname: Ardigò
authors.forename: Annalisa
authors.initials: A
authors.lastname: Patrizi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Micali
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D002615:Chemexfoliation / Q000379:methods; D002648:Child; D002951:Citrates / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008041:Linoleic Acids / Q000008:administration & dosage; D008297:Male; D011446:Prospective Studies; D011788:Quality of Life; D012459:Salicylates / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D002951:Citrates; D008041:Linoleic Acids; D012459:Salicylates; C023001:ethyl citrate; C007678:ethyl linoleate