title: [Rapid determination of illicit beta2-agonist additives in health foods and traditional Chinese patent medicines with DCBI-MS/MS method].
abstract: A novel rapid method for detection of the illicit beta2-agonist additives in health foods and traditional Chinese patent medicines was developed with the desorption corona beam ionization mass spectrometry (DCBI-MS) technique. The DCBI conditions including temperature and sample volume were optimized according to the resulting mass spectra intensity. Matrix effect on 9 beta2-agonists additives was not significant in the proposed rapid determination procedure. All of the 9 target molecules were detected within 1 min. Quantification was achieved based on the typical fragment ion in MS2 spectra of each analyte. The method showed good linear coefficients in the range of 1-100 mg x L(-1) for all analytes. The relative deviation values were between 14.29% and 25.13%. Ten claimed antitussive and antiasthmatic health foods and traditional Chinese patent medicines from local pharmacies were analyzed. All of them were negative with the proposed DCBI-MS method. Without tedious sample pretreatments, the developed DCBI-MS is simple, rapid and sensitive for rapid qualification and semi-quantification of the illicit beta2-agonist additives in health foods and traditional Chinese patent medicines.
authors.affiliation: Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha 410081, China.
authors.forename: Yu-Lan
authors.initials: YL
authors.lastname: Hou
authors.forename: Shuang
authors.initials: S
authors.lastname: Wu
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Peng
authors.initials: P
authors.lastname: Liao
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Tian
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Sun
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists / Q000032:analysis*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D058870:Food, Organic / Q000032:analysis*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D015813:Substance Abuse Detection / Q000379:methods; D053719:Tandem Mass Spectrometry
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D004365:Drugs, Chinese Herbal