title: Antifungal agents from Pseudallescheria boydii SNB-CN73 isolated from a Nasutitermes sp. termite.
abstract: Defense mutualisms between social insects and microorganisms have been described in the literature. The present article describes the discovery of a Pseudallescheria boydii strain isolated from Nasutitermes sp. The microbial symbiont produces two antifungal metabolites: tyroscherin and N-methyltyroscherin, a compound not previously described in the literature. Methylation of tyroscherin has confirmed the structure of N-methyltyroscherin. Both compounds are effective antifungal agents with favorable selectivity indices for Candida albicans and Trichophyton rubrum.
authors.affiliation: CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 1 Avenue de la Terrasse, Gif-sur-Yvette, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Nirma
authors.forename: Véronique
authors.initials: V
authors.lastname: Eparvier
authors.forename: Didier
authors.initials: D
authors.lastname: Stien
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004837:Epinephrine / Q000031:analogs & derivatives / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D005233:Fatty Alcohols / Q000737:chemistry; D006801:Humans; D020049:Isoptera / Q000382:microbiology*; D007624:KB Cells; D008825:Miconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011541:Pseudallescheria / Q000737:chemistry*; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D005233:Fatty Alcohols; C582940:N-methyltyroscherin; C495800:tyroscherin; D008825:Miconazole; D004837:Epinephrine