title: Feasibility of an outpatient HLA haploidentical stem cell transplantation program in children using a reduced-intensity conditioning regimen and CD3-CD19 depletion.
abstract: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) has been developed as an alternative transplant strategy for children with hematological disorders who do not have an HLA-matched donor. We report the analysis of the outcome for 18 consecutive pediatric patients with various hematological diseases, who underwent haplo-HSCT using a reduced-intensity conditioning regimen and CD3/CD19 depletion in an outpatient setting. Twelve of the 18 patients (66.6%) engrafted either transiently or definitively (9 patients engrafted with full donor chimerism and 3 with mixed chimerism). Six patients with acute lymphoblastic leukemia were disease-free between 2 and 35 months (median 25 months) post-HSCT. The overall survival was 33.3% with a median of 25 months (range 2-35). Our results suggest that haplo-HSCT can be a feasible therapeutic alternative for children who do not have a suitable family donor or available cord blood units. These results also demonstrate that it is possible to perform this regimen on an outpatient basis.
authors.forename: Oscar
authors.initials: O
authors.lastname: González-Llano
authors.forename: Laura Nelly
authors.initials: LN
authors.lastname: Rodríguez-Romo
authors.forename: María del Consuelo
authors.initials: Mdel C
authors.lastname: Mancías-Guerra
authors.forename: Luz
authors.initials: L
authors.lastname: Tarín-Arzaga
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Jaime-Pérez
authors.forename: José Luis
authors.initials: JL
authors.lastname: Herrera-Garza
authors.forename: Olga Graciela
authors.initials: OG
authors.lastname: Cantú-Rodríguez
authors.forename: César Homero
authors.initials: CH
authors.lastname: Gutiérrez-Aguirre
authors.forename: Ricardo Daniel
authors.initials: RD
authors.lastname: García-Sepúlveda
authors.forename: Ana Yuritzen
authors.initials: AY
authors.lastname: García-Marín
authors.forename: Laura
authors.initials: L
authors.lastname: Villarreal-Martínez
authors.forename: María del Rosario
authors.initials: Mdel R
authors.lastname: Salazar-Riojas
authors.forename: David
authors.initials: D
authors.lastname: Gómez-Almaguer
mesh_terms: D000293:Adolescent; D000328:Adult; D018941:Antigens, CD19 / Q000032:analysis / Q000276:immunology*; D017252:CD3 Complex / Q000032:analysis / Q000276:immunology*; D002648:Child; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006238:Haploidy; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008212:Lymphocyte Depletion / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D018183:Transplantation Chimera; D019172:Transplantation Conditioning / Q000379:methods*; D014182:Transplantation, Autologous; D055815:Young Adult
chemical_list: D018941:Antigens, CD19; D017252:CD3 Complex; D006680:HLA Antigens
keywords: Children; Haploidentical; Outpatient; Transplantation