title: Advances in therapy for melanoma brain metastases.
abstract: Melanoma cells frequently metastasize to the brain, and approximately 50% of patients with metastatic melanoma develop intracranial disease. Historically, central nervous system dissemination has portended a very poor prognosis. Recent advances in systemic therapies for melanoma, supported by improved local therapy control of brain lesions, have resulted in better median survival for these patients. We review current local and systemic approaches for patients with melanoma brain metastases.
authors.affiliation: Department of Medicine, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Jaclyn C
authors.initials: JC
authors.lastname: Flanigan
authors.forename: Lucia B
authors.initials: LB
authors.lastname: Jilaveanu
authors.forename: Veronica L
authors.initials: VL
authors.lastname: Chiang
authors.forename: Harriet M
authors.initials: HM
authors.lastname: Kluger
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000556:secondary / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods*; D006801:Humans; D008545:Melanoma / Q000556:secondary / Q000628:therapy*; D011379:Prognosis; D016634:Radiosurgery / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D012720:Severity of Illness Index; D012878:Skin Neoplasms / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents