title: Triterpenoids from the roots of Rhaphiolepis indica var. tashiroi and their anti-inflammatory activity.
abstract: Two new triterpenoids, 2α,3β-dihydroxyolean-11,13(18)-dien-19β,28-olide (1) and 3β,5β-dihydroxyglutinol (2), together with eight known compounds (3-10) were isolated from the roots of Rhaphiolepis indica var. tashiroi (Rosaceae). The structures of 1-10 were determined by spectroscopic techniques. Among these isolates, 2α,3β-dihydroxyolean-13(18)-en-28-oic acid (9) exhibited inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production, with an IC50 value of 16.50 μM.
authors.affiliation: School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. hschang@kmu.edu.tw.
authors.forename: Chu-Hung
authors.initials: CH
authors.lastname: Lin
authors.forename: Hsun-Shuo
authors.initials: HS
authors.lastname: Chang
authors.forename: Hsiang-Ruei
authors.initials: HR
authors.lastname: Liao
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Ian-Lih
authors.initials: IL
authors.lastname: Tsai
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D006801:Humans; D020128:Inhibitory Concentration 50; D018517:Plant Roots / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D027824:Rosaceae / Q000737:chemistry*; D013481:Superoxides / Q000378:metabolism; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D014315:Triterpenes; D013481:Superoxides