title: Standing out from the crowd: cancer stem cells in hepatocellular carcinoma.
abstract: Cancer stem cells (CSCs) drive solid tumor formation. In this issue of Cancer Cell, Zhao and colleagues indentify the calcium channel α2δ1 subunit as a new functional hepatocellular carcinoma (HCC) CSC biomarker, which is vital for CSC biology as blocking α2δ1 in combination with doxorubicin treatment hinders HCC tumor formation.
authors.affiliation: Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
authors.forename: Bruno
authors.initials: B
authors.lastname: Sainz
authors.forename: Christopher
authors.initials: C
authors.lastname: Heeschen