title: The role of 'eat-me' signals and autophagy cargo receptors in innate immunity.
abstract: Selective autophagy is an important effector mechanism of cell autonomous immunity, in particular against invasive bacterial species. Anti-bacterial autophagy is activated by rupture of bacteria-containing vacuoles and exposure of bacteria to the cytosol. The autophagy cargo receptors p62, NDP52 and Optineurin detect incoming bacteria that have become associated with specific 'eat-me' signals such as Galectin-8 and poly-ubiquitin and feed them into the autophagy pathway via interactions with phagophore-associated ATG8-like proteins. Here we review recent progress in the field regarding the origin of bacteria-associated 'eat-me' signals, the specific roles of individual cargo receptors and how disrupting cargo receptor function may be important for bacterial evasion of autophagy.
authors.affiliation: MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
authors.forename: Keith B
authors.initials: KB
authors.lastname: Boyle
authors.forename: Felix
authors.initials: F
authors.lastname: Randow
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D001343:Autophagy; D001419:Bacteria / Q000276:immunology*; D018797:Cell Cycle Proteins; D002468:Cell Physiological Phenomena; D003593:Cytoplasm / Q000382:microbiology*; D006801:Humans; D007113:Immunity, Innate; D026901:Membrane Transport Proteins; D009687:Nuclear Proteins / Q000378:metabolism; D000071456:Sequestosome-1 Protein; D035582:Transcription Factor TFIIIA / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C094297:CALCOCO2 protein, human; D018797:Cell Cycle Proteins; D026901:Membrane Transport Proteins; D009687:Nuclear Proteins; C409460:OPTN protein, human; C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein; D035582:Transcription Factor TFIIIA