title: Opposite effects of neonatal hypoxia on acute amphetamine-induced hyperlocomotion in adult and adolescent mice.
abstract: We investigated whether the effect of neonatal hypoxia on amphetamine-induced hyperlocomotion can reproduce the ontogenic (age of onset) properties of schizophrenia. Neonatal hypoxia enhanced amphetamine-induced hyperlocomotion in adult mice and decreased it in adolescent mice. These findings provide ontogenic validity for this very simple animal model of schizophrenia.
authors.affiliation: Department of Pharmacology, Universidade Federal de São Paulo, R. Botucatu, 862, Ed. Leal Prado, 1° andar, 04023062 São Paulo, SP, Brazil.
authors.forename: Sonia R
authors.initials: SR
authors.lastname: Kameda
authors.forename: Daniela F
authors.initials: DF
authors.lastname: Fukushiro
authors.forename: Raphael
authors.initials: R
authors.lastname: Wuo-Silva
authors.forename: Thaís F
authors.initials: TF
authors.lastname: Trombin
authors.forename: Roberta
authors.initials: R
authors.lastname: Procópio-Souza
authors.forename: Letícia C
authors.initials: LC
authors.lastname: Brandão
authors.forename: Leandro
authors.initials: L
authors.lastname: Sanday
authors.forename: Camilla L
authors.initials: CL
authors.lastname: Patti
authors.forename: Elisa
authors.initials: E
authors.lastname: Mári-Kawamoto
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.forename: Vânia
authors.initials: V
authors.lastname: D'Almeida
authors.forename: Roberto
authors.initials: R
authors.lastname: Frussa-Filho
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D003913:Dextroamphetamine / Q000494:pharmacology*; D004195:Disease Models, Animal; D006948:Hyperkinesis / Q000139:chemically induced*; D000860:Hypoxia / Q000523:psychology*; D008297:Male; D051379:Mice; D012559:Schizophrenia / Q000139:chemically induced*
chemical_list: D003913:Dextroamphetamine