title: Patterning surfaces for controlled platelet adhesion and detection of dysfunctional platelets.
abstract: Platelets play a fundamental role in thrombus formation and in the pathogenesis of arterial thrombosis. Patterning surfaces for controlled platelet adhesion paves the way for adhesion and activation mechanisms in platelets and detection of platelet functional defects. Here, a new and simple method based on controlled polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) on the surface of styrene-block-(ethylene-co-butylene)-block-styrene (SEBS) is shown. The competition between polymerization and degradation enables platelet adhesion on SEBS to be switched on and off. The adhesive sites of the platelets can be down to single cell level, and the dysfunctional platelets can be quantitatively detected.
authors.affiliation: Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ye
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shi
authors.forename: Shing-Chung
authors.initials: SC
authors.lastname: Wong
authors.forename: Jianwen
authors.initials: J
authors.lastname: Hou
authors.forename: Hengchong
authors.initials: H
authors.lastname: Shi
authors.forename: Jinghua
authors.initials: J
authors.lastname: Yin
mesh_terms: D000475:Alkenes / Q000494:pharmacology*; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000473:pathology* / Q000648:ultrastructure; D005030:Ethylenes / Q000494:pharmacology*; D018625:Microscopy, Atomic Force; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011817:Rabbits; D020058:Styrene / Q000494:pharmacology*; D013499:Surface Properties
chemical_list: D000475:Alkenes; D005030:Ethylenes; C558934:butylene; D020058:Styrene; C036216:ethylene