title: Identification and determination of selected histamine antagonists by densitometric method.
abstract: The conditions for identification were determined for four histamine antagonists: clemastine fumarate, loratadine, cetirizine dihydrochloride and desloratadine by TLC (thin-layer chromatography) method. The selected chromatographic conditions were used to develop a densitometric method for the content determination of the histamine antagonists in medicinal products and substances. The statistical data showed adequate accuracy and precision of the developed methods.
authors.affiliation: Department of Basic and Applied Pharmacy, National Medicines Institute, 30/34 Chelmska St., 00-725 Warszawa, Poland. kczerwinska@il.waw.pl
authors.forename: Krystyna
authors.initials: K
authors.lastname: Czerwińska
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Wyszomirska
authors.forename: Aleksander P
authors.initials: AP
authors.lastname: Mazurek
mesh_terms: D002138:Calibration; D017332:Cetirizine / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer / Q000592:standards; D002974:Clemastine / Q000032:analysis*; D003720:Densitometry / Q000592:standards; D006633:Histamine Antagonists / Q000032:analysis*; D057230:Limit of Detection; D017336:Loratadine / Q000031:analogs & derivatives* / Q000032:analysis*; D012015:Reference Standards; D012044:Regression Analysis
chemical_list: D006633:Histamine Antagonists; D017336:Loratadine; D002974:Clemastine; C121345:desloratadine; D017332:Cetirizine