title: Extracellular superoxide dismutase, a potential extracellular biomarker candidate for prolactinoma.
abstract: OBJECTIVE
  To investigate whether the extracellular superoxide dismutase (EC-SOD) and manganese superoxide dismutase (Mn-SOD) level changes during prolactinoma (PRL) development.
  
  
  METHODS
  Surgical tissues from 37 female patients with PRL were tested for Mn-SOD and serum samples from such PRL patients were tested for EC-SOD level changes with Western Blot. The MnSOD level from blood cells was also investigated to show whether the Mn-SOD variation could locate tumorigenesis tissues.
  
  
  RESULTS
  According to the patients' age analysis, age 20-40 years is high risk for getting PRL. There is a positive relationship between the PRL severity and EC-SOD. The Mn-SOD level from surgical tissues, but not blood cells, also shows a corresponding positive relationship to PRL severity, which indicates that elevated Mn-SOD might only happen in PRL tumorigenesis tissues.
  
  
  CONCLUSIONS
  Extracellular superoxide dismutase is an extracellular protein and the serum EC-SOD could be a good candidate for the diagnoses of prolactinoma.
authors.affiliation: Section of Neurosurgery, First Affiliated Hospital of Baotou Medical College, Inner Mongolia, China. jh_bt@163.com
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: R
authors.initials: R
authors.lastname: Shi
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001773:Blood Cells / Q000378:metabolism; D015153:Blotting, Western; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000378:metabolism*; D015175:Prolactinoma / Q000378:metabolism*; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000378:metabolism*; D055815:Young Adult; D000099156:Superoxide Dismutase 2
chemical_list: D014408:Biomarkers, Tumor; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2; C441642:SOD3 protein, human