title: Intraocular soluble intracellular adhesion molecule-1 correlates with subretinal fluid height of diabetic macular edema.
abstract: OBJECTIVE
  To investigate the correlations between aqueous concentrations of vascular endothelial growth factor (VEGF), monocyte chemoattractant protein-1 (MCP-1), soluble intracellular adhesion molecule-1 (sICAM-1) and diabetic macular edema (DME).
  
  
  METHODS
  VEGF, MCP-1 and sICAM-1 concentrations in aqueous humor samples of 22 patients with DME and 23 patients with cataract of a control group were measured with solid-phase chemiluminescence immunoassay.
  
  
  RESULTS
  Aqueous VEGF (89.2 ± 58.5 pg/ml versus 48.5 ± 27.8 pg/ml, P = 0.006), MCP-1 (684.2 ± 423.4 pg/ml versus 432.4 ± 230.4 pg/ml, P = 0.019) and sICAM-1 (3213.8 ± 2581.6 pg/ml versus 260.2 ± 212.2 pg/ml, P < 0.001) all vary significantly between DME group and control group. Maximum height of submacular fluid measured by Optical coherence tomography (OCT) was significantly associated with aqueous sICAM-1 (r = -0.45, P = 0.034). The maximum height of macular thickness measured by OCT was not significantly associated with either VEGF (P = 0.300), MCP-1 (P = 0.320) or sICAM-1 (P = 0.285).
  
  
  CONCLUSIONS
  Our results suggest that sICAM-1 may majorly contribute to the formation of subretinal fluid in DME patients and imply that MCP-1 and sICAM-1 may be the potential therapy targets, besides VEGF.
authors.affiliation: Department of Ophthalmology, the Affiliated Hospital of Inner Mongolia Medical College, Hohhot, Inner Mongolia, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhu
authors.forename: He
authors.initials: H
authors.lastname: Zhu
authors.forename: Chunyan
authors.initials: C
authors.lastname: Wang
authors.forename: Dayong
authors.initials: D
authors.lastname: Yang
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D018932:Chemokine CCL2 / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D007118:Immunoassay; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008269:Macular Edema / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D008297:Male; D058471:Subretinal Fluid / Q000378:metabolism*; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D015415:Biomarkers; D018932:Chemokine CCL2; D042461:Vascular Endothelial Growth Factor A; D018799:Intercellular Adhesion Molecule-1