title: Anticoagulation in patients with left ventricular systolic dysfunction and sinus rhythm: when?
abstract: Left ventricular (LV) systolic dysfunction and chronic systolic heart failure (HF) predispose to intraventricular thrombus formation and embolization resulting in stroke. Current guideline recommends the use of oral anticoagulants in patients with atrial fibrillation and history of previous thromboembolism. However, anticoagulant treatment in patients with LV systolic dysfunction with sinus rhythm and without history of previous thromboembolism is still on debate. Recent epidemiologic date has reported increased stroke rate in patients with systolic HF shortly after diagnosis. This review focuses on the possible causes of increased stroke rate shortly after the diagnosis of HF and subsequently suggests a rationale for the use of oral anticoagulant in these patient groups.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Trakya University, Edirne, Turkey nasirsivri@hotmail.com.
authors.forename: Nasir
authors.initials: N
authors.lastname: Sivri
authors.affiliation: Division of Cardiology, Middle East Hospital, Mersin, Turkey.
authors.forename: Ertan
authors.initials: E
authors.lastname: Yetkin
authors.affiliation: Department of Cardiology, Faculty of Medicine, Bozok University, Yozgat, Turkey.
authors.forename: Gulacan Ozgun
authors.initials: GO
authors.lastname: Tekin
authors.affiliation: Department of Cardiology, Faculty of Medicine, Trakya University, Edirne, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Yalta
authors.affiliation: Department of Cardiology and Angiology, University Hospital of Muenster, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Waltenberger
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D054143:Heart Failure, Systolic / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D020521:Stroke / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D013616:Tachycardia, Sinus / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D013923:Thromboembolism / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000925:Anticoagulants
keywords: anticogulant; stroke; thrombosis