title: Synthesis of the C1-C21 domain of azaspiracids-1 and -3.
abstract: An efficient synthesis of the C1-C21 fragment of azaspiracids-1 and -3 is described. This features a Nozaki-Hiyama-Kishi reaction to couple the AB and CD ring precursors and formation of the THF-fused ABCD trioxadispiroketal system under thermodynamic conditions.
authors.affiliation: Department of Chemistry & Biochemistry, The Ohio State University , Columbus, Ohio 43210, United States.
authors.forename: Zhigao
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yue
authors.initials: Y
authors.lastname: Ding
authors.forename: Jianyan
authors.initials: J
authors.lastname: Xu
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Forsyth
mesh_terms: D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D008387:Marine Toxins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013816:Thermodynamics; D000095702:Polyether Toxins
chemical_list: D005663:Furans; D008387:Marine Toxins; D011714:Pyrans; D013141:Spiro Compounds; C406592:azaspiracid; D000095702:Polyether Toxins; C520447:azaspiracid-2