title: Survival rates and prognostic factors for infiltrating salivary duct carcinoma: Analysis of 228 cases from the Surveillance, Epidemiology, and End Results database.
abstract: BACKGROUND
  The survival rates and prognostic factors for salivary duct carcinoma (SDC) are not clear.
  
  
  METHODS
  Survival estimates and prognostic factors were evaluated for 228 patients with SDC identified from the Surveillance, Epidemiology, and End Results (SEER) database.
  
  
  RESULTS
  Median overall survival (OS) duration for patients with SDC was 79 months and 5-year disease-specific survival (DSS) rate was 64%. Among patients with SDC with lymph node involvement, larger primary tumor size (>3 cm) was associated with twice the risk of death (p < .03). Factors predictive of improved DSS were age (p = .01), tumor size (p = .006), tumor grade (p = .02), and lymph node involvement (p < .001). Adjuvant radiotherapy did not improve survival when compared to surgery alone for early-stage (I-II) disease (p = .28).
  
  
  CONCLUSIONS
  Younger patients with SDC (<50 years) showed a better prognosis. Primary tumor size and lymph node involvement were independent and additive risk factors for poor prognosis. The role of adjuvant radiotherapy in the treatment of SDC needs to be explored further.
authors.affiliation: Department of Head and Neck/Plastic and Reconstructive Surgery, Roswell Park Cancer Institute, Buffalo, New York; Department of Dentistry and Maxillofacial Prosthetics, Roswell Park Cancer Institute, Buffalo, New York.
authors.forename: Vijayvel
authors.initials: V
authors.lastname: Jayaprakash
authors.forename: Mihai
authors.initials: M
authors.lastname: Merzianu
authors.forename: Graham W
authors.initials: GW
authors.lastname: Warren
authors.forename: Hassan
authors.initials: H
authors.lastname: Arshad
authors.forename: Wesley L
authors.initials: WL
authors.lastname: Hicks
authors.forename: Nestor R
authors.initials: NR
authors.lastname: Rigual
authors.forename: Maureen A
authors.initials: MA
authors.lastname: Sullivan
authors.forename: Mukund
authors.initials: M
authors.lastname: Seshadri
authors.forename: James R
authors.initials: JR
authors.lastname: Marshall
authors.forename: David M
authors.initials: DM
authors.lastname: Cohan
authors.forename: Yujie
authors.initials: Y
authors.lastname: Zhao
authors.forename: Anurag K
authors.initials: AK
authors.lastname: Singh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D018714:Radiotherapy, Adjuvant; D018570:Risk Assessment; D018426:SEER Program; D018987:Salivary Ducts / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome; D014481:United States
keywords: SEER; prognostic factors; radiation; salivary duct carcinoma; survival rates