title: Management considerations for purported spontaneous regression of hepatocellular carcinoma: a case report.
abstract: Spontaneous regression of hepatocellular carcinoma (HCC) is an extraordinary phenomenon that occurs rarely. While more than 80 cases have been described, most have been established via radiological findings or examination of biopsy tissues rather than via pathological examination of a resected specimen. The present report describes a purported case of spontaneous regression of HCC as indicated by radiological examination. Subsequent immunostaining of surgically resected specimens revealed viable cancer cells, though only necrotic tissues were seen on hematoxylin and eosin staining. These data indicate that viable cancer cells may still be present even if imaging findings suggest spontaneous regression of HCC. Therefore, these patients should receive aggressive treatment similar to that used for patients with established HCC.
authors.affiliation: Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Fukuoka, Imari, Japan ; Department of Surgery, Yamamoto Memorial Hospital, Imari, Japan.
authors.forename: Takahide
authors.initials: T
authors.lastname: Sasaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Fukumori
authors.forename: Kentaroh
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Fumio
authors.initials: F
authors.lastname: Yamamoto
authors.forename: Hirotsune
authors.initials: H
authors.lastname: Igimi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yamashita
keywords: Hepatocellular carcinoma; Spontaneous regression