title: [Rapid identification 15 effective components of anti common cold medicine with MRM by LC-MS/MS].
abstract: This paper reports the establishment of a method for rapid identification 15 effective components of anti common cold medicine (paracetamol, aminophenazone, pseudoephedrine hydrochloride, methylephedrine hydrochloride, caffeine, amantadine hydrochloride, phenazone, guaifenesin, chlorphenamine maleate, dextromethorphen hydrobromide, diphenhydramine hydrochloride, promethazine hydrochloride, propyphenazone, benorilate and diclofenac sodium) with MRM by LC-MS/MS. The samples were extracted by methanol and were separated from a Altantis T3 column within 15 min with a gradient of acetonitrile-ammonium acetate (containing 0.25% glacial acetic acid), a tandem quadrupole mass spectrometer equipped with electrospray ionization source (ESI) was used in positive ion mode, and multiple reaction monitoring (MRM) was performed for qualitative analysis of these compounds. The minimum detectable quantity were 0.33-2.5 microg x kg(-1) of the 15 compounds. The method is simple, accurate and with good reproducibility for rapid identification many components in the same chromatographic condition, and provides a reference for qualitative analysis illegally added chemicals in anti common cold medicine.
authors.affiliation: Hebei Institute for Food and Drug Control, Shijiazhuang 050011, China.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Jiang
authors.forename: Xi-Ru
authors.initials: XR
authors.lastname: Zhang
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Zhang
authors.forename: Geng-Shen
authors.initials: GS
authors.lastname: Song
mesh_terms: D000082:Acetaminophen / Q000032:analysis; D000083:Acetanilides / Q000032:analysis; D000547:Amantadine / Q000032:analysis; D000632:Aminopyrine / Q000032:analysis; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D058633:Antipyretics / Q000032:analysis*; D000983:Antipyrine / Q000031:analogs & derivatives / Q000032:analysis; D002110:Caffeine / Q000032:analysis; D002744:Chlorpheniramine / Q000032:analysis; D002853:Chromatography, Liquid; D004008:Diclofenac / Q000032:analysis; D004155:Diphenhydramine / Q000032:analysis; D004340:Drug Contamination; D004355:Drug Stability; D004809:Ephedrine / Q000031:analogs & derivatives / Q000032:analysis; D006140:Guaifenesin / Q000032:analysis; D011398:Promethazine / Q000032:analysis; D054199:Pseudoephedrine / Q000032:analysis; D015203:Reproducibility of Results; D012459:Salicylates / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry
chemical_list: D000083:Acetanilides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D058633:Antipyretics; D012459:Salicylates; D000632:Aminopyrine; D004008:Diclofenac; D000082:Acetaminophen; D002110:Caffeine; D002744:Chlorpheniramine; D006140:Guaifenesin; C041707:N-methylephedrine; D054199:Pseudoephedrine; D004155:Diphenhydramine; D000547:Amantadine; D011398:Promethazine; D004809:Ephedrine; C009077:propyphenazone; D000983:Antipyrine; C084830:benorilate