title: Receptor-specific delivery of protein antigen to dendritic cells by a nanoemulsion formed using top-down non-covalent click self-assembly.
abstract: A new class of targeted and immune-evading nanocarrier made using only biological components and facile processes is assembled in a bottom-up fashion. Simple top-down sequential addition of immune-evading or receptor-specific antibody elements conjugated to biosurfactant protein DAMP4 promotes self-assembly at an interface previously formed in the presence of peptide surfactant AM1, leading to a functional display at the interface through non-covalent molecular self-assembly.
authors.affiliation: The University of Queensland, Australian Institute for Bioengineering and Nanotechnology, St Lucia QLD 4072, Australia.
authors.forename: B J
authors.initials: BJ
authors.lastname: Zeng
authors.forename: Y P
authors.initials: YP
authors.lastname: Chuan
authors.forename: B
authors.initials: B
authors.lastname: O'Sullivan
authors.forename: I
authors.initials: I
authors.lastname: Caminschi
authors.forename: M H
authors.initials: MH
authors.lastname: Lahoud
authors.forename: R
authors.initials: R
authors.lastname: Thomas
authors.forename: A P J
authors.initials: AP
authors.lastname: Middelberg
mesh_terms: D000818:Animals; D000941:Antigens / Q000737:chemistry / Q000378:metabolism*; D002460:Cell Line; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000378:metabolism*; D004655:Emulsions / Q000737:chemistry*; D051379:Mice; D008810:Mice, Inbred C57BL; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D014867:Water / Q000737:chemistry
chemical_list: D000941:Antigens; D004655:Emulsions; D011506:Proteins; D014867:Water
keywords: antigens; dendritic cells; drug delivery; proteins; receptor specific; targeted delivery