title: A "turn-on" fluorescent chemosensor for zinc ion with facile synthesis and application in live cell imaging.
abstract: Compound 1 was facilely synthesized through a one step reaction from commercially available materials. As a sensitive and selective "turn-on" fluorescent chemosensor for Zn(II), 1 exhibits a 40-fold fluorescence enhancement response to Zn(II) over other physiological relevant metal ions in aqueous solution at neutral pH. Furthermore, 1 could be efficiently delivered to live cells for bioimaging of Zn(II).
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.forename: Aijun
authors.initials: A
authors.lastname: Tong
mesh_terms: D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D005618:Fresh Water / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000737:chemistry; D008856:Microscopy, Fluorescence; D013050:Spectrometry, Fluorescence; D015032:Zinc / Q000032:analysis*
chemical_list: C584230:(5-tert-butyl-2-hydroxyisophthalaldehyde-bis-2-pyridinehydrazone)Zn(II); D056831:Coordination Complexes; D005456:Fluorescent Dyes; D007477:Ions; D015032:Zinc