title: Mutation rate at 17 Y-STR loci in "Father/Son" pairs from moroccan population.
abstract: Precise knowledge of mutation rate at Y-STRs loci is essential for a correct evaluation of typing results in forensic casework and specially kinship genetic studies. In this study, we have examined 252 confirmed and unrelated father/son sample pairs from Moroccan population using the 17 Y-STR markers DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a, DYS385b, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, and Y-GATA-H4 of the AmpFlSTR Yfiler™ kit used in routine casework. We observed a total of 15 single repeat mutations between fathers and sons as mutational events. Nine mutations resulted in the gain of a repeat in the son and six resulted in a loss of a repeat. The average mutation rate in the studied sample is 3.5×10(-3) (95% CI 2-5.8×10(-3)). Furthermore, Y-STRs mutation occurrence seems to be 4 times more frequent than autosomal STRs mutation in this sample.
authors.affiliation: Service Biologie-Empreintes Génétiques, Laboratoire de Police Scientifique, 4 Rue Bnou Bouraid, Quartir Palmiers-Maarif, Casablanca, Morocco. laouina.adil@gmail.com
authors.forename: Adil
authors.initials: A
authors.lastname: Laouina
authors.forename: Sellama
authors.initials: S
authors.lastname: Nadifi
authors.forename: Redouane
authors.initials: R
authors.lastname: Boulouiz
authors.forename: Marzouk
authors.initials: M
authors.lastname: El Arji
authors.forename: Jalal
authors.initials: J
authors.lastname: Talbi
authors.forename: Brahim
authors.initials: B
authors.lastname: El Houate
authors.forename: Hakima
authors.initials: H
authors.lastname: Yahia
authors.forename: Faiza
authors.initials: F
authors.lastname: Chbel
mesh_terms: D044383:Black People / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D016172:DNA Fingerprinting / Q000379:methods*; D004252:DNA Mutational Analysis; D005220:Fathers; D053803:Forensic Genetics / Q000379:methods*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D009018:Morocco; D059645:Mutation Rate; D010334:Paternity
keywords: AmpFlSTR Yfiler™; Moroccan; Mutational events; Y-STRs