title: The importance of oncogenic transcription factors for oral cancer pathogenesis and treatment.
abstract: Oral squamous cell carcinoma is a major cause of morbidity and mortality worldwide. Current experimental evidence shows that most important risk factors for oral cancer include tobacco use and excessive alcohol consumption and less well-defined risks include viral infection and a diet deficient in antioxidants. The positive correlation between various risk/etiologic factors of oral cancer and the activation of various transcription factors (TFs) has been reported in the literature. Although initially, TFs were considered to be very difficult targets for use in clinical treatment, recent technological advances have provided the ability to control these factors of cancer progression. This review focuses on the role of oncogenic transcription factors in oral cancer, their modes of activation through various biological pathways, the promises and pitfalls in viewing them as potent oncotargets, the way they can be controlled based on the current understanding, and the future research to be done in this area.
authors.affiliation: Centre for Life Sciences, School of Natural Sciences, Central University of Jharkhand, Ranchi, Jharkhand, India.
authors.forename: Govinda Raju
authors.initials: GR
authors.lastname: Yedida
authors.forename: Siddavaram
authors.initials: S
authors.lastname: Nagini
authors.forename: Rajakishore
authors.initials: R
authors.lastname: Mishra
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D018390:Gene Targeting; D006801:Humans; D009062:Mouth Neoplasms / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D015533:Transcriptional Activation / Q000235:genetics
chemical_list: D015513:Oncogene Proteins; D014157:Transcription Factors