title: [Expression of long non-coding RNA HOTAIR mRNA in ovarian cancer].
abstract: OBJECTIVE
  To investigate the long non-coding RNA HOTAIR (long non-coding HOX antisense intergenic RNA) by examining HOTAIR expression levels in ovarian cancer tissue and normal ovarian tissue.
  
  
  METHODS
  The mRNA of long non-coding RNA HOTAIR expressions were detected by real-time fluorescence quantitative PCR in ovarian cancer (44) and normal ovary tissues (14).
  
  
  RESULTS
  The expression of HOTAIR in ovarian cancer tissue was higher than that in normal ovarian tissue (1.26 +/- 0.27 vs. 0.14 +/- 0.09, P < 0.05). The expression was statistically higher in poorly differentiated ovarian cancer than poorly-moderately, moderately-well, and well-differentiated ones (1.65 +/- 0.41 vs. 0.39 +/- 0.14, P < 0.05).
  
  
  CONCLUSIONS
  RNA HOTAIR expressions were higher in ovarian cancer; it may play a role in ovarian cancer, and become a biomarker for malignant degree of ovarian cancer and may provide a novel therapeutic target for ovarian cancer.
authors.affiliation: Laboratory of Genetics, West China Institute of Women and Children's Health, West China Second Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Cui
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Xie
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.forename: Xin-Lian
authors.initials: XL
authors.lastname: Chen
authors.forename: Shan-Ling
authors.initials: SL
authors.lastname: Liu
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Hu
mesh_terms: D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000378:metabolism*; D012333:RNA, Messenger
chemical_list: C561566:HOTAIR long untranslated RNA, human; D062085:RNA, Long Noncoding; D012333:RNA, Messenger