title: Is polycystic ovarian syndrome a risk factor for urolithiasis?
abstract: Urinary stone disease is a complex multifactorial disorder influenced by both intrinsic and environmental factors. It is generally known that age and sex are risk factors for urinary stone disease. Also men have higher mean urinary oxalate concentrations than women. In addition, in animal and human studies, testosterone has been shown to increase the formation of urinary stones. This suggests that sex hormones are considered to be involved in the pathogenesis of stone disease. Polycystic ovary syndrome (PCOS) is one of the most frequent endocrine disorders of women in the reproductive age, affecting 5-10 % of women in this life span. It is characterized with chronic anovulation\oligo-ovulation, clinical or biochemical evidence of hyperandrogenism and polycystic ovaries on ultrasound examination. Hyperandrogenism, the main feature of PCOS, may trigger the urinary stone formation besides hirsutism, alopecia and acne. Therefore, we hypothesize that PCOS accompanied by hyperandrogenism may be a risk factor in the formation of urinary stone disease.
authors.forename: Ikbal
authors.initials: I
authors.lastname: Kaygusuz
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Karatas
authors.forename: Hasan
authors.initials: H
authors.lastname: Kafali
authors.forename: Ersin
authors.initials: E
authors.lastname: Cimentepe
authors.forename: Dogan
authors.initials: D
authors.lastname: Unal
mesh_terms: D000818:Animals; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications / Q000378:metabolism; D008297:Male; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000378:metabolism; D012307:Risk Factors; D012727:Sex Characteristics; D052878:Urolithiasis / Q000209:etiology* / Q000378:metabolism
chemical_list: D012739:Gonadal Steroid Hormones