title: Sirt4: the glutamine gatekeeper.
abstract: Little is known about how DNA damage and metabolism are interconnected. In this issue of Cancer Cell, Jeong and colleagues report that an important component of the DNA damage response is the SIRT4-mediated blockade of glutamine catabolism. Failure to shut down glutamine consumption results in unscheduled proliferation, genomic instability, and cancer.
authors.affiliation: Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
authors.forename: Pablo J
authors.initials: PJ
authors.lastname: Fernandez-Marcos
authors.forename: Manuel
authors.initials: M
authors.lastname: Serrano