title: The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes.
abstract: Phosphatidylinositol phosphates are key regulators of vesicle identity, formation and trafficking. In mammalian cells, the evolutionarily conserved class III PtdIns 3-kinase PIK3C3/VPS34 is part of a large multiprotein complex that catalyzes the localized phosphorylation of phosphatidylinositol to phosphatidylinositol-3-phosphate (PtdIns3P). We demonstrate that PIK3C3 has a key function in vesicular trafficking, endocytosis and autophagosome-autolysosome formation in the highly specialized glomerular podocytes.
authors.affiliation: Renal Division; University Hospital Freiburg; Freiburg, Germany.
authors.forename: Wibke
authors.initials: W
authors.lastname: Bechtel
authors.forename: Martin
authors.initials: M
authors.lastname: Helmstädter
authors.forename: Jan
authors.initials: J
authors.lastname: Balica
authors.forename: Björn
authors.initials: B
authors.lastname: Hartleben
authors.forename: Christoph
authors.initials: C
authors.lastname: Schell
authors.forename: Tobias B
authors.initials: TB
authors.lastname: Huber
mesh_terms: D000818:Animals; D001343:Autophagy; D058546:Class III Phosphatidylinositol 3-Kinases / Q000172:deficiency / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology; D004705:Endocytosis; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D010588:Phagosomes / Q000378:metabolism*; D050199:Podocytes / Q000166:cytology* / Q000201:enzymology*
chemical_list: D058546:Class III Phosphatidylinositol 3-Kinases
keywords: Pik3c3; Vps34; autophago-lysosomal formation; autophagy; endocytosis; glomerulosclerosis; phosphoinositide 3-kinase; podocyte; proteinuria