title: IL-10-producing lymphocytes in inflammatory disease.
abstract: IL-10 is an anti-inflammatory cytokine that plays a significant role in controlling inflammation and modulating adaptive immune responses that cause tissue damage. IL-10-producing lymphocytes contribute to the delicate balance between inflammation and immunoregulation, and are thus regarded as a kind of "regulatory cells." Dysregulation of these cells is linked with susceptibility to numerous inflammatory diseases. In this review, we summarized what is known about the regulatory effects of IL-10 produced by lymphocytes, including T cells, B cells and natural killer cells, in inflammatory diseases. We hope to augment immune responses or prevent immunopathology through making some small changes in the levels of IL-10 produced by lymphocytes, or in the cellular location where it is produced.
authors.affiliation: Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yao
authors.forename: Alain R
authors.initials: AR
authors.lastname: Simard
authors.forename: Fu-Dong
authors.initials: FD
authors.lastname: Shi
authors.forename: Junwei
authors.initials: J
authors.lastname: Hao
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D060151:B-Lymphocytes, Regulatory / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D016753:Interleukin-10 / Q000235:genetics / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D016753:Interleukin-10