title: Virulence of pertactin-negative Bordetella pertussis isolates from infants, France.
abstract: Bordetella pertussis isolates that do not express pertactin (PRN) are increasing in regions where acellular pertussis vaccines have been used for >7 years. We analyzed data from France and compared clinical symptoms among infants <6 months old infected by PRN-positive or PRN-negative isolates. No major clinical differences were found between the 2 groups.
authors.affiliation: Institut Pasteur, Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Bodilis
authors.forename: Nicole
authors.initials: N
authors.lastname: Guiso
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D001428:Bacterial Vaccines; D001886:Bordetella pertussis / Q000302:isolation & purification / Q000378:metabolism / Q000472:pathogenicity*; D005260:Female; D005602:France; D006801:Humans; D007223:Infant; D008297:Male; D032541:Mass Vaccination; D011795:Surveys and Questionnaires; D014774:Virulence; D010566:Virulence Factors, Bordetella / Q000378:metabolism*; D014917:Whooping Cough / Q000382:microbiology* / Q000517:prevention & control
chemical_list: D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D010566:Virulence Factors, Bordetella; C068929:pertactin
keywords: Bordetella pertussis; acellular vaccines; bacteria; coccobacillus; immunization; pertactin; vaccination; vaccine