title: Nanostructured medical device coatings based on self-assembled poly(lactic-co-glycolic acid) nanoparticles.
abstract: Here we present a new method for providing nanostructured drug-loaded polymer films which enable control of film surface morphology and delivery of therapeutic agents. Silicon wafers were employed as models for implanted biomaterials and poly(lactic-co-glycolic acid) (PLGA) nanoparticles were assembled onto the silicon surface by electrostatic interaction. Monolayers of the PLGA particles were deposited onto the silicon surface upon incubation in an aqueous particle suspension. Particle density and surface coverage of the silicon wafers were varied by altering particle concentration, incubation time in nanoparticle suspension and ionic strength of the suspension. Dye loaded nanoparticles were prepared and assembled to silicon surface to form nanoparticle films. Fluorescence intensity measurements showed diffusion-controlled release of the dye over two weeks and atomic force microscopy (AFM) analysis revealed that these particles remained attached to the surface during the incubation time. This work suggests that coating implants with PLGA nanoparticles is a versatile technique which allows drug release from the implant surface and modulation of surface morphology.
authors.affiliation: Department of Pharmaceutical Technology and Biopharmaceutics, Marburg University, 35037 Marburg, Germany.
authors.forename: Eyas
authors.initials: E
authors.lastname: Dayyoub
authors.forename: Christian
authors.initials: C
authors.lastname: Hobler
authors.forename: Pierina
authors.initials: P
authors.lastname: Nonnweiler
authors.forename: Michael
authors.initials: M
authors.lastname: Keusgen
authors.forename: Udo
authors.initials: U
authors.lastname: Bakowsky
mesh_terms: D020099:Coated Materials, Biocompatible; D004864:Equipment and Supplies; D005456:Fluorescent Dyes; D019344:Lactic Acid / Q000737:chemistry*; D049329:Nanostructures; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D005456:Fluorescent Dyes; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid