title: Pericytes, stem-cell-like cells, but not mesenchymal stem cells are recruited to support microvascular tube stabilization.
abstract: An experimental model is introduced for the induction of endothelial cell (EC) tubulogenesis after 24 h of incubation on micropatterned polymer surfaces. Pericytes or mesenchymal stem cells are added separately to this system to evaluate their effect on tubular stabilization. In the absence of additional cells, the tubular structures are lost after 36 h. Addition of only pericytes, however, stabilizes the EC vasculogenic tubes.
authors.affiliation: Université Bordeaux 1-CNRS, UMR5248, Institut Européen de Chimie et Biologie, 2, rue Robert Escarpit, F-33607 Pessac, France. omar.zouani@inserm.fr.
authors.forename: Omar F
authors.initials: OF
authors.lastname: Zouani
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Lei
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Durrieu
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D018919:Neovascularization, Physiologic / Q000502:physiology; D020286:Pericytes / Q000166:cytology*
keywords: mesenchymal stem cells; pericytes; surface micropatterning; tubulogenesis