title: Pleiotropic functions of fibroblast growth factor signaling in embryonic mammary gland development.
abstract: The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted for induction, maintenance and morphogenesis of the mammary glands. Understanding the mechanism whereby FGF signaling regulates the fundamental cell behavior during normal mammary gland develop may facilitate determination of the consequences of its deregulation during breast cancer progression.
authors.affiliation: Division in Anatomy and Developmental Biology, Department of Oral Biology, Brain Korea 21 project, Oral Science Research Institute, College of Dentistry, Yonsei Center of Biotechnology, Yonsei University, Seoul, Korea.
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Kim
authors.forename: Han-Sung
authors.initials: HS
authors.lastname: Jung
authors.forename: Pengfei
authors.initials: P
authors.lastname: Lu
mesh_terms: D000818:Animals; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008321:Mammary Glands, Animal / Q000196:embryology* / Q000378:metabolism; D042361:Mammary Glands, Human / Q000196:embryology* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D005346:Fibroblast Growth Factors