title: Aspergillus vertebral osteomyelitis in immunocompetent subjects: case report and review of the literature.
abstract: Aspergillus spondylodiscitis (AS) is rare in immunocompetent (IC) patients. A 65-year-old diabetic IC male subject presented with cervical AS 18 months after otomycosis. Two serological tests, mastoidectomy and biopsy of the sphenoid bone, were negative. A prevertebral biopsy identified A. flavus. The patient was successfully treated with voriconazole. Forty-three cases of AS in IC patients have been published. A predisposition was found in 84 % of cases. Fever was reported in 20 % of cases, whereas neurological defects were present in 41 %. Serology was inconsistently positive (5/7) and diagnosis was confirmed by biopsy or surgery. A. fumigatus was the most frequently isolated species (74 %). All episodes were medically treated, associated with surgery in 57 % of cases, and 73 % of patients fully recovered. AS must be discussed in IC patients presenting with risk factors, including diabetes mellitus. Biopsy is necessary to confirm diagnosis, since serology offers low sensitivity. Nevertheless, the prognosis is good.
authors.affiliation: Infectious Diseases Unit, University Hospital of Caen, 14000, Caen, France.
authors.forename: A
authors.initials: A
authors.lastname: Nicolle
authors.forename: A
authors.initials: A
authors.lastname: de la Blanchardière
authors.forename: J
authors.initials: J
authors.lastname: Bonhomme
authors.forename: M
authors.initials: M
authors.lastname: Hamon
authors.forename: R
authors.initials: R
authors.lastname: Leclercq
authors.forename: M
authors.initials: M
authors.lastname: Hitier
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage; D001228:Aspergillosis / Q000175:diagnosis* / Q000382:microbiology; D001230:Aspergillus / Q000302:isolation & purification*; D001706:Biopsy; D048909:Diabetes Complications; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000175:diagnosis* / Q000382:microbiology; D011743:Pyrimidines / Q000008:administration & dosage; D013166:Spondylitis / Q000175:diagnosis* / Q000382:microbiology; D014230:Triazoles / Q000008:administration & dosage; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole