title: Madelung's disease associated with polyneuropathy and symptomatic hypokalemia.
abstract: Madelung's disease (multiple symmetric lipomatosis) is a rare disease characterized by abnormal diffuse lipomatosis in proximal upper limbs and neck. Previous reports have shown that this disease is associated with alcoholism, polyneuropathy, mitochondrial disease, and glucose intolerance. Here, we describe a 46-year-old man having Madelung's disease associated with polyneuropathy and symptomatic hypokalemia. He presented with insidious-onset weakness and numbness in lower limbs for 7 years and recent deterioration of symptoms. Proximal weakness improved with potassium supplement. Our observation may extend the phenotype of Madelung's disease to hypokalemic periodic paralysis.
authors.affiliation: Department of Neurology, En Chu Kong Hospital, Taipei County, Taiwan.
authors.forename: Hoi-Fong
authors.initials: HF
authors.lastname: Chan
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.forename: Cheng-Huai
authors.initials: CH
authors.lastname: Lin
authors.forename: Rong-Chi
authors.initials: RC
authors.lastname: Chen
mesh_terms: D006801:Humans; D007008:Hypokalemia / Q000209:etiology*; D008069:Lipomatosis, Multiple Symmetrical / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011115:Polyneuropathies / Q000209:etiology*