title: Perspectives in targeting miRNA function.
abstract: First oligonucleotide analogues that inhibit miRNA function are currently investigated in clinical trials. In addition, several alternative methods are under development that may allow for controlling miRNA function by small molecules-mediated inhibiting of its biogenesis. In this perspectives article, we provide a short overview on recent developments in this field.
authors.affiliation: Humboldt Universität zu Berlin, Institute for Chemistry, Brook-Taylor-Str. 2, 12489 Berlin, Germany.
authors.forename: Christiane
authors.initials: C
authors.lastname: Schöniger
authors.forename: Christoph
authors.initials: C
authors.lastname: Arenz
mesh_terms: D006801:Humans; D035683:MicroRNAs / Q000037:antagonists & inhibitors* / Q000235:genetics*; D009841:Oligonucleotides / Q000494:pharmacology*
chemical_list: D035683:MicroRNAs; D009841:Oligonucleotides
keywords: Antagomirs; High throughput screening; Small molecules; miRNA