title: Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells.
abstract: The p38α mitogen-activated protein kinase (MAPK) inhibitor SB203580 had been reported to enhance the cardiomyogenesis of human embryonic stem cells (hESCs). To investigate if tri-substituted imidazole analogues of SB203580 are equally effective inducers for cardiomyogenesis of hESCs, and if there is a correlation between p38α MAPK inhibition and cardiomyogenesis, we designed and synthesized a series of novel tri-substituted imidazoles with a range of p38α MAPK inhibitory activities. Our studies demonstrated that suitably designed analogues of SB203580 can also be inducers of cardiomyogenesis in hESCs and that cell growth is affected by changes in the imidazole structures.
authors.affiliation: Institute of Chemical and Engineering Sciences, 8 Biomedical Grove, Neuros #07-01, Singapore 138665, Singapore.
authors.forename: Joo-Leng
authors.initials: JL
authors.lastname: Low
authors.forename: Gerrit
authors.initials: G
authors.lastname: Jürjens
authors.forename: Jayasree
authors.initials: J
authors.lastname: Seayad
authors.forename: Jasmine
authors.initials: J
authors.lastname: Seow
authors.forename: Sherwin
authors.initials: S
authors.lastname: Ting
authors.forename: Filip
authors.initials: F
authors.lastname: Laco
authors.forename: Shaul
authors.initials: S
authors.lastname: Reuveny
authors.forename: Steve
authors.initials: S
authors.lastname: Oh
authors.forename: Christina L L
authors.initials: CL
authors.lastname: Chai
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D053595:Embryonic Stem Cells / Q000166:cytology*; D006801:Humans; D007093:Imidazoles / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D048308:Mitogen-Activated Protein Kinase 14 / Q000037:antagonists & inhibitors / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000166:cytology; D011485:Protein Binding; D011725:Pyridines / Q000737:chemistry* / Q000378:metabolism
chemical_list: D007093:Imidazoles; D011725:Pyridines; C029899:imidazole; D048308:Mitogen-Activated Protein Kinase 14; C093642:SB 203580