title: The unfolded protein response in plants: a fundamental adaptive cellular response to internal and external stresses.
abstract: In eukaryotic cells, proteins that enter the secretory pathway are translated on membrane-bound ribosomes and translocated into the endoplasmic reticulum (ER), where they are subjected to chaperone-assisted folding, post-translational modification and assembly. During the evolution of the eukaryotic cell, a homeostatic mechanism was developed to maintain the functions of the ER in the face of various internal and external stresses. The most severe stresses imposed on eukaryotic cells can induce ER stress that can overwhelm the processing capacity of the ER, leading to the accumulation of unfolded proteins in the ER lumen. To cope with this accumulation of unfolded proteins, the unfolded protein response (UPR) is activated to alter transcriptional programs through inositol-requiring enzyme 1 (IRE1) and bZIP17/28 in plants. In addition to transcriptional induction of UPR genes, quality control (QC), translational attenuation, ER-associated degradation (ERAD) and ER stress-induced apoptosis are also conserved as fundamental adaptive cellular responses to ER stress in plants. This article is part of a Special Issue entitled: Translational Plant Proteomics.
authors.affiliation: Division of Applied Life Science (BK21 Program) and PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju, 660-701, Republic of Korea.
authors.forename: Wahyu Indra
authors.initials: WI
authors.lastname: Duwi Fanata
authors.forename: Sang Yeol
authors.initials: SY
authors.lastname: Lee
authors.forename: Kyun Oh
authors.initials: KO
authors.lastname: Lee
mesh_terms: D017209:Apoptosis / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000502:physiology; D059865:Endoplasmic Reticulum Stress; D060746:Endoplasmic Reticulum-Associated Degradation / Q000502:physiology*; D010944:Plants / Q000235:genetics* / Q000378:metabolism; D013312:Stress, Physiological / Q000502:physiology*; D056811:Unfolded Protein Response / Q000502:physiology*
keywords: Apoptosis; Endoplasmic reticulum stress; Endoplasmic reticulum-associated degradation; Plants; Quality control; Unfolded protein response