title: Polyurethane-based drug delivery systems.
abstract: Polyurethanes (PUs) are formed by a reaction between isocyanates and diols to yield polymers with urethane bonds (-NH-COO-) in their main chain. A great variety of building blocks is commercially available that allows the chemical and physical properties of PUs to be tailored to their target applications, particularly for the biomedical and pharmaceutical fields. This article reviews the synthesis and characterization of PUs and PU-copolymers, as well as their in vitro and in vivo biodegradability and biocompatibility. Particular emphasis is placed on the use of PUs for the controlled release of drugs and for the (targeted) delivery of biotherapeutics.
authors: Department of Chemistry and Biochemistry, National Chung Cheng University, 168 University Rd., Chia-Yi, Taiwan. chejyc@ccu.edu.tw
authors: Jong Yuh
authors: JY
authors: Cherng
authors: Ting Yi
authors: TY
authors: Hou
authors: Mei Fen
authors: MF
authors: Shih
authors: Herre
authors: H
authors: Talsma
authors: Wim E
authors: WE
authors: Hennink
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D011140:Polyurethanes / Q000737:chemistry*
chemical_list: D011140:Polyurethanes