title: Immunohistochemical profiling of Ameloblastomas using cytokeratin, vimentin, smooth muscle actin, CD34 and S100.
abstract: BACKGROUND
  Ameloblastoma is characterized as a slow growing, non-metastatic and a locally invasive tumor with a high risk of recurrence. Immunohistochemical evaluation of ameloblastomas using epithelial and connective tissue specific markers help in studying the histogenesis and assessing the biological behavior. The aim of the study was to study the expression patterns of cytokeratin, vimentin, smooth muscle actin (SMA), S100 and CD34 in ameloblastomas.
  
  
  METHODS
  The material for the study consisted of 24 cases of ameloblastomas. The excised specimens were grossed and bits were taken from different areas of the specimen. Based on the histopathology, the cases were classified into different types and stained for immunohistochemistry.
  
  
  RESULTS
  The cases showed strong positivity to cytokeratin, vimentin, moderate positivity for SMA and S100. Five cases were also moderately positive for CD34 in blood vessels.
  
  
  CONCLUSIONS
  The results and hypothesis achieved from the study, proved to be consistent, not only augmenting the already existing hypothesis but also imparting new concepts of hypothesis.
authors: Department of Oral and Maxillofacial Pathology, College of Dental Surgery, Saveetha University, Chennai, India.
authors: Herald J
authors: HJ
authors: Sherlin
authors: Anuja
authors: A
authors: Natesan
authors: Priya
authors: P
authors: Ram
authors: Pratibha
authors: P
authors: Ramani
authors: Chandrasekar
authors: C
authors: Thiruvenkadam
keywords: Ameloblastoma; CD34; S100; cytokeratin; smooth muscle actin; vimentin
references: Eur J Cancer B Oral Oncol. 1995 Mar;31B(2):86-99
references: 7633291
references: Oral Surg Oral Med Oral Pathol. 1977 Feb;43(2):233-55
references: 264648
references: J Invest Dermatol. 2004 Jul;123(1):23-33
references: 15191538
references: Oral Dis. 2003 Jan;9(1):1-6
references: 12617250
references: Braz Dent J. 1990;1(1):5-15
references: 2135878
references: Bull Tokyo Dent Coll. 2002 Feb;43(1):13-21
references: 12013821
references: Oral Maxillofac Surg Clin North Am. 2004 Aug;16(3):309-22
references: 18088733
references: N Engl J Med. 1971 Nov 18;285(21):1182-6
references: 4938153
references: Nat Rev Mol Cell Biol. 2002 May;3(5):349-63
references: 11988769
references: J Nihon Univ Sch Dent. 1993 Jun;35(2):104-8
references: 7692015
references: Oral Oncol. 2005 Nov;41(10):1028-33
references: 16139563
references: J Histochem Cytochem. 2000 Jul;48(7):979-84
references: 10858275
references: J Oral Pathol Med. 2005 Feb;34(2):70-6
references: 15641985
references: Basic Appl Histochem. 1990;34(2):135-41
references: 2222400
references: Connect Tissue Res. 1995;32(1-4):71-6
references: 7554938
references: J Dermatol Sci. 2000 Feb;22(2):71-9
references: 10674819
references: Acta Histochem Suppl. 1991;41:117-27
references: 1725827
references: Curr Opin Biotechnol. 2003 Oct;14(5):538-46
references: 14580586
references: J Oral Pathol Med. 2002 Jan;31(1):28-34
references: 11896820
references: Int J Dev Biol. 2004;48(5-6):509-17
references: 15349825
references: Oral Surg Oral Med Oral Pathol. 1984 Nov;58(5):575-8
references: 6083519
references: J Oral Maxillofac Surg. 1991 Mar;49(3):282-8; discussion 288-9
references: 1704908