title: MUC1 and HER2 might be associated with invasive phenotype of intraductal papillary mucinous neoplasm.
abstract: OBJECTIVE
  The purpose of this study was to clarify the biomarkers which distinguish invasive Intraductal papillary mucinous neoplasms (IPMNs) from noninvasive IPMNs.
  
  
  METHODS
  In tumor specimens from sixty patients with IPMNs (42 noninvasive IPMNs and 18 invasive IPMNs) who underwent surgical resection at our institute, we analyzed the correlation between the immunohistochemical expression level of MUC1, MUC2, MUC4, MUC5AC, p53, VEGFR2, HER2, and HER3.
  
  
  RESULTS
  The 5-year survival rate was 100% in noninvasive IPMNs, while that of invasive IPMNs was only 36.5%. MUC1, MUC4, HER2 and HER3 were significantly associated with invasive IPMNs in univariate analysis. Multivariate analysis revealed that MUC1 and HER2 were significantly associated with invasive IPMNs. The 5-year survival of IPMN patients with either MUC1-positive and/or HER2-positive (54.5%) is significantly poorer than that of IPMN patients with MUC1 negative and HER2 negative (100%).
  
  
  CONCLUSIONS
  MUC1 and HER2 might be closely associated with invasive phenotype of IPMNs.
authors: Go
authors: G
authors: Ohira
authors: Kenjiro
authors: K
authors: Kimura
authors: Nobuya
authors: N
authors: Yamada
authors: Ryosuke
authors: R
authors: Amano
authors: Bunzo
authors: B
authors: Nakata
authors: Yosuke
authors: Y
authors: Doi
authors: Akihiro
authors: A
authors: Murata
authors: Masakazu
authors: M
authors: Yashiro
authors: Sayaka
authors: S
authors: Tanaka
authors: Masahiko
authors: M
authors: Ohsawa
authors: Kenichi
authors: K
authors: Wakasa
authors: Kosei
authors: K
authors: Hirakawa
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D021441:Carcinoma, Pancreatic Ductal / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis*; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D010641:Phenotype; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*
chemical_list: D018396:Mucin-1; D018719:Erb-b2 Receptor Tyrosine Kinases; C060192:MUC1 protein, human; C508053:ERBB2 protein, human