title: Population genetics of Haemophilus influenzae serotype a in three Canadian provinces.
abstract: Haemophilus influenzae serotype a (Hia) is an important pathogen since the introduction of vaccines for control of disease due to serotype b strains. Using a sodC-based polymerase chain reaction, Hia can be divided into 2 phylogenetic divisions, each with their own unique multilocus sequence types. Most Canadian Hia belongs to clonal division I and the ST-23 clonal complex. The recently described hypervirulent clone of ST-4 was found in a single Canadian isolate. Therefore, surveillance of invasive H. influenzae disease should include serotyping to detect Hia and multilocus sequence typing to detect hypervirulent clones.
authors: Vaccine Preventable Bacterial Diseases Division, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada. raymond.tsang@phac-aspc.gc.ca
authors: Raymond S W
authors: RS
authors: Tsang
authors: Michelle
authors: M
authors: Shuel
authors: John
authors: J
authors: Wylie
authors: Brigitte
authors: B
authors: Lefebvre
authors: Linda
authors: L
authors: Hoang
authors: Dennis K S
authors: DK
authors: Law
mesh_terms: D002170:Canada; D021821:Communicable Diseases, Emerging / Q000382:microbiology; D006192:Haemophilus Infections / Q000382:microbiology*; D006193:Haemophilus influenzae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D058885:Multilocus Sequence Typing; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012703:Serotyping; D013482:Superoxide Dismutase / Q000235:genetics
chemical_list: D013482:Superoxide Dismutase