title: Alternative cleavage and polyadenylation: the long and short of it.
abstract: Cleavage and polyadenylation (C/P) of nascent transcripts is essential for maturation of the 3' ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have elucidated the machinery responsible for the seemingly simple C/P reaction. Recent genomic analyses have indicated that most eukaryotic genes have multiple cleavage and polyadenylation sites (pAs), leading to transcript isoforms with different coding potentials and/or variable 3' untranslated regions (UTRs). As such, alternative cleavage and polyadenylation (APA) is an important layer of gene regulation impacting mRNA metabolism. Here, we review our current understanding of APA and recent progress in this field.
authors: Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA. btian@umdnj.edu
authors: Bin
authors: B
authors: Tian
authors: James L
authors: JL
authors: Manley
mesh_terms: D006868:Hydrolysis; D011061:Poly A / Q000737:chemistry*; D020543:Proteome; D059467:Transcriptome
chemical_list: D020543:Proteome; D011061:Poly A
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