title: Rutosides for prevention of post-thrombotic syndrome.
abstract: BACKGROUND
  Post-thrombotic syndrome (PTS) is a long-term complication of deep venous thrombosis (DVT) that is characterised by pain, swelling, and skin changes in the affected limb. One in three patients with DVT will develop post-thrombotic sequelae within five years. The current standard care for the prevention of PTS following DVT is elastic compression stockings. Rutosides are a group of compounds derived from horse chestnut (Aesculus hippocastanum), a traditional herbal remedy for treating oedema formation in chronic venous insufficiency (CVI). However, it is not known whether rutosides are effective and safe in the prevention of post-thrombotic syndrome.
  
  
  OBJECTIVE
  To determine the effectiveness and safety of rutosides for prevention of PTS in patients with DVT, compared to placebo, no intervention, or reference medication.
  
  
  METHODS
  The Cochrane Peripheral Vascular Diseases Group Trials Search Co-ordinator searched the Specialised Register (last searched October 2012) and CENTRAL (2012, Issue 9). Clinical trials databases were searched for details of ongoing and unpublished studies.
  
  
  METHODS
  We planned to include trials of rutosides versus any alternative (placebo, no intervention, or reference medication) in the prevention of PTS in patients with DVT.
  
  
  METHODS
  Two authors independently assessed studies for inclusion and intended to extract information from the trials.
  
  
  RESULTS
  No studies were identified comparing rutosides versus any alternative in the prevention of PTS.
  
  
  CONCLUSIONS
  As there were no studies identified in this review it is not possible to support the use of rutosides in the prevention of PTS. Some studies suggest that rutosides may provide short-term relief of PTS symptoms. However, there is nothing published on their use as a preventative therapy for PTS. High quality randomised controlled trials of rutoside versus any alternative are required to build the evidence base in this area.
authors: Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK. Dinanda.Kolbach@maastrichtuniversity.nl
authors: Joanne R
authors: JR
authors: Morling
authors: Su Ern
authors: SE
authors: Yeoh
authors: Dinanda N
authors: DN
authors: Kolbach
mesh_terms: D031319:Aesculus / Q000737:chemistry*; D006801:Humans; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use*; D054070:Postthrombotic Syndrome / Q000517:prevention & control*; D012431:Rutin / Q000627:therapeutic use*; D020246:Venous Thrombosis / Q000150:complications
chemical_list: D010936:Plant Extracts; D012431:Rutin