title: Relationships between exhaled nitric oxide and atopy profiles in children with asthma.
abstract: OBJECTIVE
  We examined whether fractional exhaled nitric oxide (FeNO) levels are associated with atopy profiles in terms of mono-sensitization and poly-sensitization in asthmatic children.
  
  
  METHODS
  A total of 119 children underwent an assessment that included FeNO measurements, spirometry, methacholine challenge, and measurement of blood eosinophil count, serum total IgE, and serum eosinophil cationic protein (ECP). We also examined sensitization to five classes of aeroallergens (house dust mites, animal danders, pollens, molds, and cockroach) using skin prick testing. The children were divided into three groups according to their sensitization profiles to these aeroallergens (non-sensitized, mono-sensitized, and poly-sensitized).
  
  
  RESULTS
  The geometric means (range of 1 SD) of FeNO were significantly different between the three groups (non-sensitized, 18.6 ppb [10.0-34.7 ppb]; mono-sensitized, 28.8 ppb [16.6-50.1 ppb]; and poly-sensitized, 44.7 ppb [24.5-81.3 ppb], P=0.001). FeNO levels were correlated with serum total IgE concentrations, peripheral blood eosinophilia, and serum ECP levels to different degrees.
  
  
  CONCLUSIONS
  FeNO levels vary according to the profile of atopy, as determined by positive skin prick test results to various classes of aeroallergens. FeNO is also moderately correlated with serum total IgE, blood eosinophilia, and serum ECP. These results suggest that poly-sensitized asthmatic children may have the highest risk of airway inflammation.
authors: Department of Pediatrics, Hanil General Hospital, Seoul, Korea.
authors: Won-Nyung
authors: WN
authors: Jang
authors: In-Su
authors: IS
authors: Park
authors: Chang-Hee
authors: CH
authors: Choi
authors: Siegfried
authors: S
authors: Bauer
authors: Samuel
authors: S
authors: Harmin
authors: Sung Chul
authors: SC
authors: Seo
authors: Ic Sun
authors: IS
authors: Choi
authors: Ji Tae
authors: JT
authors: Choung
authors: Young
authors: Y
authors: Yoo
keywords: Atopy; asthma; child; fractional exhaled nitric oxide; mono-sensitization; poly-sensitization
references: J Allergy Clin Immunol. 2007 Feb;119(2):405-13
references: 17291857
references: Clin Exp Allergy. 1997 Jun;27(6):646-52
references: 9208185
references: Am J Respir Crit Care Med. 2001 Jun;163(7):1693-722
references: 11401895
references: Allergy. 2003 Jul;58(7):559-69
references: 12823111
references: Am J Respir Crit Care Med. 2005 Apr 15;171(8):912-30
references: 15817806
references: Allergy Asthma Proc. 2011 Mar-Apr;32(2):119-26
references: 21439165
references: Pediatr Pulmonol. 2006 Jul;41(7):635-42
references: 16703576
references: Respir Med. 2006 Jan;100(1):167-73
references: 15885997
references: J Allergy Clin Immunol. 2006 Dec;118(6):1218-25
references: 17157650
references: Thorax. 2001 Nov;56(11):857-62
references: 11641510
references: J Asthma. 2010 Aug;47(6):604-8
references: 20626309
references: Am J Respir Crit Care Med. 1995 Sep;152(3):1107-36
references: 7663792
references: Respir Res. 2009 Apr 21;10:28
references: 19379527
references: Eur J Med Res. 2009 Dec 7;14 Suppl 4:9-13
references: 20156716
references: J Allergy Clin Immunol. 2004 Nov;114(5):1040-5
references: 15536407
references: Am J Respir Crit Care Med. 1999 Jan;159(1):69-73
references: 9872820
references: Allergy. 2005 Apr;60(4):464-8
references: 15727577
references: Respir Med. 2005 Jun;99(6):779-87
references: 15878496
references: Allergol Immunopathol (Madr). 2008 Nov-Dec;36(6):331-5
references: 19150032
references: J Allergy Clin Immunol. 2003 Nov;112(5):883-92
references: 14610474
references: Allergy. 2000 Jul;55(7):600-8
references: 10921458
references: Pediatr Clin North Am. 1992 Dec;39(6):1277-91
references: 1437320
references: Ann Allergy Asthma Immunol. 2005 Nov;95(5):433-7
references: 16312165
references: Clin Exp Allergy. 2002 Apr;32(4):532-6
references: 11972598
references: Thorax. 2002 May;57(5):383-7
references: 11978911
references: Eur Respir J. 2000 May;15(5):839-43
references: 10853846
references: Chest. 2004 Nov;126(5):1540-5
references: 15539724
references: Ann Allergy Asthma Immunol. 1996 Mar;76(3):239-44
references: 8634876
references: J Asthma. 2005 May;42(4):291-5
references: 16032938
references: J Allergy Clin Immunol. 1975 Oct;56(4):323-7
references: 1176724
references: Am J Respir Crit Care Med. 2000 Mar;161(3 Pt 1):685-7
references: 10712303
references: Respiration. 2008;75(4):386-92
references: 17596680