title: Preparation and properties of α-calcium sulphate hemihydrate and β-tricalcium phosphate bone substitute.
abstract: Autogenous bone graft carries the risk of complications. In contrast, artificial bone graft provides initial strength and allows new bone ingrowth. In this study, we examined methods of preparation of α-calcium sulphate hemihydrate (α-CSH) and β-tricalcium phosphate (β-TCP), and a composite of the two materials. Characterization of the materials was determined with X-ray diffraction, differential thermal analysis (DTA), scanning electron microscopy (SEM), and porosity analysis. β-TCP exhibited the spatial structure and porosity of normal bone with a macropore size of 50-400 μm and some 1 μm micropores. α-CSH exhibited a regular crystal structure. A combined material was prepared in a 1:1 weight ratio, and in a rabbit model, the rate of new bone mineralization was similar to that of autogenous bone graft. The combined material of β-TCP and α-CSH in this study may provide similar efficacy as autogenous bone graft.
authors: Department of Orthopedics, General Hospital of People's Liberation Army, Beijing, China.
authors: Keya
authors: K
authors: Mao
authors: Feihu
authors: F
authors: Zhou
authors: Fuzai
authors: F
authors: Cui
authors: Jiangtao
authors: J
authors: Li
authors: Xijun
authors: X
authors: Hou
authors: Peng
authors: P
authors: Li
authors: Mingkui
authors: M
authors: Du
authors: Maohua
authors: M
authors: Liang
authors: Yan
authors: Y
authors: Wang
mesh_terms: D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry*; D002130:Calcium Phosphates / Q000138:chemical synthesis / Q000737:chemistry*; D002133:Calcium Sulfate / Q000138:chemical synthesis / Q000737:chemistry*; D004055:Differential Thermal Analysis; D008855:Microscopy, Electron, Scanning; D014961:X-Ray Diffraction
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D002133:Calcium Sulfate