title: Toward optimization of a novel trileaflet polymeric prosthetic heart valve via device thrombogenicity emulation.
abstract: Aortic stenosis is the most prevalent and life-threatening form of valvular heart disease. It is primarily treated via open-heart surgical valve replacement with either a tissue or a mechanical prosthetic heart valve (PHV), each prone to degradation and thrombosis, respectively. Polymeric PHVs may be optimized to eliminate these complications, and they may be more suitable for the new transcatheter aortic valve replacement procedure and in devices like the total artificial heart. However, the development of polymer PHVs has been hampered by persistent in vivo calcification, degradation, and thrombosis. To address these issues, we have developed a novel surgically implantable polymer PHV composed of a new thermoset polyolefin called cross-linked poly(styrene-block-isobutylene-block-styrene), or xSIBS, in which key parameters were optimized for superior functionality via our device thrombogenicity emulation methodology. In this parametric study, we compared our homogeneous optimized polcymer PHV to a prior composite polymer PHV and to a benchmark tissue valve. Our results show significantly improved hemodynamics and reduced thrombogenicity in the optimized polymer PHV compared to the other valves. These results indicate that our new design may not require anticoagulants and may be more durable than its predecessor, and validate the improvement, toward optimization, of this novel polymeric PHV design.
authors: Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794, USA.
authors: Thomas E
authors: TE
authors: Claiborne
authors: Michalis
authors: M
authors: Xenos
authors: Jawaad
authors: J
authors: Sheriff
authors: Wei-Che
authors: WC
authors: Chiu
authors: Joao
authors: J
authors: Soares
authors: Yared
authors: Y
authors: Alemu
authors: Shikha
authors: S
authors: Gupta
authors: Stefan
authors: S
authors: Judex
authors: Marvin J
authors: MJ
authors: Slepian
authors: Danny
authors: D
authors: Bluestein
mesh_terms: D001021:Aortic Valve / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000601:surgery*; D003198:Computer Simulation; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation* / Q000379:methods; D006439:Hemodynamics; D006801:Humans; D015539:Platelet Activation / Q000187:drug effects*; D011108:Polymers / Q000627:therapeutic use*; D011474:Prosthesis Design; D015203:Reproducibility of Results; D013917:Thrombin / Q000627:therapeutic use*
chemical_list: D011108:Polymers; D013917:Thrombin; C478632:Thrombogen
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