title: Construction of a chiral quaternary carbon center by catalytic asymmetric alkylation of 2-arylcyclohexanones under phase-transfer conditions.
abstract: In this paper, we present an asymmetric alkylation of modified 2-arylcyclohexanones that employs a novel chiral ammonium bromide as a phase-transfer catalyst and an achiral auxiliary as a controller to improve the enantioselectivity to afford optically enriched products having a chiral quaternary carbon center.
authors: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
authors: Taichi
authors: T
authors: Kano
authors: Yumi
authors: Y
authors: Hayashi
authors: Keiji
authors: K
authors: Maruoka
mesh_terms: D000478:Alkylation; D001965:Bromides / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003512:Cyclohexanones / Q000737:chemistry*; D008958:Models, Molecular; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001965:Bromides; D003512:Cyclohexanones; D000644:Quaternary Ammonium Compounds; C036468:cyclohexanone; D002244:Carbon; C051470:ammonium bromide