title: [HSP70, an erythropoiesis regulator that determines the fate of erythroblasts between death and differentiation].
abstract: Erythropoiesis is finely regulated by two major cytokines, stem cell factor (SCF) and erythropoietin (Epo). Decrease levels of Epo result in caspase activation and erythroid progenitors apoptosis. However, normal erythroid cell maturation requests caspase activation and cleavage of various caspase substrates, except the erythroid transcription factor GATA-1, that is protected by interaction with the chaperone HSP70 in the nucleus. Therefore, molecular abnormalities associated with decrease of HSP70 expression in the nucleus may result in ineffective erythropoiesis characterized by apoptosis and impaired maturation of erythroid precursors. These findings open new potential targeted therapies for erythroid disorders.
authors: CNRS UMR 8143, labex des globules rouges GR-ex, hôpital Necker, institut Imagine, université Sorbonne Paris Cité, Paris Descartes, Paris, France. ohermine@gmail.com
authors: O
authors: O
authors: Hermine
authors: J-B
authors: JB
authors: Arlet
authors: J-A
authors: JA
authors: Ribeil
authors: F
authors: F
authors: Guillerm
authors: J
authors: J
authors: Vandekerkhove
authors: G
authors: G
authors: Courtois
mesh_terms: D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000502:physiology; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000378:metabolism; D004789:Enzyme Activation; D004900:Erythroblasts / Q000166:cytology*; D004905:Erythrocyte Aging; D004920:Erythropoiesis / Q000502:physiology*; D004921:Erythropoietin / Q000502:physiology; D050982:GATA1 Transcription Factor / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D059748:Proteolysis; D019089:Stem Cell Factor / Q000502:physiology; D013789:Thalassemia / Q000378:metabolism
chemical_list: D050982:GATA1 Transcription Factor; D018840:HSP70 Heat-Shock Proteins; D009363:Neoplasm Proteins; D019089:Stem Cell Factor; D004921:Erythropoietin; D020169:Caspases