title: Experimental simulation of radio- and chemoradio stomatitis in rats.
abstract: Experimental models of stomatitis developing in response to an isolated (radiation) and combined (radiation and chemical) exposure of experimental animals, were created. The severity of radiation-induced stomatitis was determined by the dose of radiation exposure. Additional exposure to a chemical factor (cyclophosphamide) augmented the destructive effect of ionizing radiation on the buccal mucosa of rats.
authors: Department of Military Toxicology and Medical Protection, S. M. Kirov Military Medical Academy, St. Petersburg, Russia. antu-anna@yandex.ru
authors: A A
authors: AA
authors: Antushevich
authors: A N
authors: AN
authors: Grebenyuk
authors: A Y
authors: AY
authors: Antushevich
authors: L P
authors: LP
authors: Polevay
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity*; D001066:Appetite / Q000187:drug effects / Q000528:radiation effects; D059248:Chemoradiotherapy / Q000009:adverse effects; D003520:Cyclophosphamide / Q000633:toxicity*; D004195:Disease Models, Animal; D009043:Motor Activity / Q000187:drug effects / Q000528:radiation effects; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D013280:Stomatitis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide