title: The novel human MRC1 gene polymorphisms are associated with susceptibility to pulmonary tuberculosis in Chinese Uygur and Kazak populations.
abstract: The MRC1 gene, encoding the human mannose receptor (MR), is a member of the C-type lectin receptors family. MR can recognize and bind to Mycobacterium tuberculosis by the extracellular structure, and play a role in antigen-presenting and maintaining a stable internal environment. This study aimed to investigate potential associations of SNPs in exon 7 of the MRC1 gene with pulmonary tuberculosis (TB). G1186A, G1195A, T1212C, C1221G, C1303T and C1323T were genotyped using PCR and DNA sequencing in 595 Chinese Uygur and 513 Kazak subjects. In the Uygur, the frequency of allele G (P=0.031, OR=1.29, 95% CI=1.02-1.62) and AA genotype (P=0.033, OR=1.64, 95% CI=1.04-2.60) for G1186A was lower in the pulmonary TB than healthy control and were significantly correlated with pulmonary TB. After adjustment for age and gender, G1186A was found to be additive models in association with pulmonary TB (P=0.04, OR=1.27, 95% CI=1.01-1.60). By calculating linkage disequilibrium, the frequency of haplotype GGTCCT (P=0.032, OR=0.75, 95% CI=0.57-0.97) and GGTCCC (P=0.044, OR=0.57, 95% CI=0.33-0.99) was significantly associated with pulmonary TB. No association was found between other SNPs and pulmonary TB. In the Kazak, all SNPs were not associated with pulmonary TB. Our results suggest that genetic factors play an important role in susceptibility to pulmonary TB at the individual level, and provide an experimental basis to clarify the pathogenesis of pulmonary TB.
authors: Institute of Cell Biology, Zhejiang University, No. 866, Yuhangtang Road, Hangzhou, 310058, China.
authors: Xing
authors: X
authors: Zhang
authors: Xiang
authors: X
authors: Li
authors: Wanjiang
authors: W
authors: Zhang
authors: Liliang
authors: L
authors: Wei
authors: Tingting
authors: T
authors: Jiang
authors: Zhongliang
authors: Z
authors: Chen
authors: Chunping
authors: C
authors: Meng
authors: Jiyan
authors: J
authors: Liu
authors: Fang
authors: F
authors: Wu
authors: Chong
authors: C
authors: Wang
authors: Fujian
authors: F
authors: Li
authors: Xiaojun
authors: X
authors: Sun
authors: Zhongjie
authors: Z
authors: Li
authors: Ji-Cheng
authors: JC
authors: Li
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002681:China; D005006:Ethnicity / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008562:Membrane Glycoproteins; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011971:Receptors, Immunologic / Q000235:genetics*; D012737:Sex Factors; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: C573543:MRC1 protein, human; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic
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