title: [Some properties of auditory neuron's model trained by firing caused by tones modulated by low-frequency noise].
abstract: In many sensory systems the formation of burst firing can be observed along a way from the periphery to the central nuclei. We investigate the putative transformation of spontaneous activity in the auditory pathway using a neuron model trained by real firing recorded in the auditory nuclei of the frog. The model has 200 separate inputs (neuronal spines). It is supposed that every spine is a coincidence detector. Its output (synaptic potential) sharply increases at emergence of the precisely certain interpulse interval in an input pulse sequence. If the total synaptic potentials excess a threshold, the model generates output spike, which changes weight of all spines according to the simplified Hebb principle. The model was trained by real firing caused in the auditory nuclei of the frog by tones modulated by low-frequency noise in the frequency ranges of 0-15 Hz, 0-50 Hz or 0-150 Hz. After that training the synaptic weights of every spine essentially changed. Thus, along with some increase of weights of spines tuned to boundary frequencies of modulating noise, the most characteristic change was the emphasizing weights of spines tuned to short interpulse intervals. As a result the spontaneous activity passed through the trained model became much more bursting. Efficiency of a signal transmission in model was higher when input spontaneous activity of real cells contains bursts of spikes. Results of modeling are discussed in connection with modern physiological data demonstrating the functional advantage of bursting.
authors: N G
authors: NG
authors: Bibikov
authors: D Iu
authors: DIu
authors: Grigor'ev
authors: S V
authors: SV
authors: Nizamov
mesh_terms: D000161:Acoustic Stimulation; D001306:Auditory Pathways; D003056:Cochlear Nerve / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology