title: Highly purified collagen coating enhances tissue adherence and integration properties of monofilament polypropylene meshes.
abstract: OBJECTIVE
  Complications related to tissue integration of polypropylene implants used in the treatment of pelvic organ prolapse are relatively prevalent. Collagen, a biocompatible, less immunogenic material with modulating properties on the inflammatory process, may improve polypropylene integration. The objective was to study biomechanical and histological effects of monofilament polypropylene mesh coated with purified collagen gel.
  
  
  METHODS
  Forty rats were implanted with two fragments of polypropylene mesh in their abdominal walls (one on each side of the linea alba). One of the fragments had a collagen gel coating (group I) while the other one did not (group II). The animals were euthanized at 7, 14, 90, and 180 days after implantation and their abdominal walls were excised for analysis.
  
  
  RESULTS
  The biomechanical study showed that mesh adherence to neighboring tissue increased significantly in group II (p < 0.05). Acute (p < 0.001) and chronic (p = 0.004) inflammatory responses as well as granulation tissue formation (p = 0.001) were less intense in group II at 7 and 14 days. Granulomatous inflammation and foreign body reaction was less significant at 7 days in group II (p = 0.029 and p < 0.001). The birefringence analysis showed higher mean brightness density in the late phase of implantation in group II meshes (p = 0.000).
  
  
  CONCLUSIONS
  Polypropylene mesh coated with purified collagen gel increases adherence to tissue, promotes a less intense and lasting inflammatory response and triggers a greater organization and packing arrangement of collagen fibers in the late phase of implantation.
authors: Biomaterials Research Unit, Division of Urology, University of Campinas, São Paulo, Brazil, rsinis02@gmail.com.
authors: Rodrigo Teixeira
authors: RT
authors: Siniscalchi
authors: Marli
authors: M
authors: Melo
authors: Paulo César Rodrigues
authors: PC
authors: Palma
authors: Inácio Maria
authors: IM
authors: Dal Fabbro
authors: Benedicto de Campos
authors: Bde C
authors: Vidal
authors: Cassio Luiz Zanettini
authors: CL
authors: Riccetto
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000818:Animals; D001696:Biomechanical Phenomena; D003094:Collagen; D005260:Female; D005782:Gels; D008422:Materials Testing; D008859:Microscopy, Polarization; D023421:Models, Animal; D056887:Pelvic Organ Prolapse / Q000601:surgery; D011126:Polypropylenes; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh
chemical_list: D005782:Gels; D011126:Polypropylenes; D003094:Collagen
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