title: 5-aminolevulinic acid-based photodynamic therapy for the treatment of condylomata acuminata in Chinese patients: a meta-analysis.
abstract: OBJECTIVE
  This meta-analysis was designed to assess the efficacy of topical 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) in Chinese patients with condylomata acuminata (CA).
  
  
  METHODS
  Electronic literature databases (Medline, Embase, Cochrane Library, China National Knowledge Infrastructure, and Wanfang database) were searched for relevant randomized controlled trials (RCTs) published prior to October 2012. Only RCTs that compared ALA-PDT to non-ALA-PDT for patients with genital condylomata were selected. The outcomes included the recurrence rate and adverse events. The risk ratios (RRs) and 95% confidence intervals (CIs) were calculated as the ALA-PDT vs. without ALA-PDT.
  
  
  RESULTS
  Twenty RCTs composed of 1903 patients (ALA-PDT, n = 1106; non-ALA-PDT, n = 797) were included in the meta-analysis. ALA-PDT decreased the recurrence rate within 12 week after treatment (vs. without ALA-PDT, RR: 0.28, 95% CI: 0.22-0.35) and 24 week after treatment (vs. without ALA-PDT, RR: 0.24, 95% CI: 0.17-0.34) in a fixed-effect model. The common adverse events related ALA-PDT included a mild burning and/or stinging sensation, erythema, mild edema, erosion, and hyperpigmentation.
  
  
  CONCLUSIONS
  Local application of ALA-PDT reduced recurrence rate vs. without ALA-PDT. The use of ALA-PDT should be considered as a feasible therapy for the treatment of CA.
authors: Department of Dermatology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. yingzuolin@hotmail.com
authors: Zuolin
authors: Z
authors: Ying
authors: Xiaojie
authors: X
authors: Li
authors: Hong
authors: H
authors: Dang
mesh_terms: D000622:Aminolevulinic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D044466:Asian People; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000208:ethnology; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy* / Q000208:ethnology; D005832:Genital Diseases, Male / Q000188:drug therapy* / Q000208:ethnology; D006801:Humans; D016239:MEDLINE; D008297:Male; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000009:adverse effects; D016032:Randomized Controlled Trials as Topic
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid