title: A novel cognitive-neurophysiological state biomarker in premanifest Huntington's disease validated on longitudinal data.
abstract: In several neurodegenerative diseases, like Huntington's disease (HD), treatments are still lacking. To determine whether a treatment is effective, sensitive disease progression biomarkers are especially needed for the premanifest phase, since this allows the evaluation of neuroprotective treatments preventing, or delaying disease manifestation. On the basis of a longitudinal study we present a biomarker that was derived by integrating behavioural and neurophysiological data reflecting cognitive processes of action control. The measure identified is sensitive enough to track disease progression over a period of only 6 month. Changes tracked were predictive for a number of clinically relevant parameters and the sensitivity of the measure was higher than that of currently used parameters to track prodromal disease progression. The study provides a biomarker, which could change practice of progression diagnostics in a major basal ganglia disease and which may help to evaluate potential neuroprotective treatments in future clinical trials.
authors: Institute for Cognitive Neuroscience, Biopsychology, Ruhr-University Bochum, Germany. christian.beste@rub.de
authors: Christian
authors: C
authors: Beste
authors: Ann-Kathrin
authors: AK
authors: Stock
authors: Vanessa
authors: V
authors: Ness
authors: Rainer
authors: R
authors: Hoffmann
authors: Carsten
authors: C
authors: Lukas
authors: Carsten
authors: C
authors: Saft
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism* / Q000473:pathology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D055815:Young Adult
chemical_list: D015415:Biomarkers
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