title: Histidine-rich protein 2 plasma levels predict progression to cerebral malaria in Malawian children with Plasmodium falciparum infection.
abstract: Some children with uncomplicated malaria progress to cerebral malaria despite appropriate treatment; identifying them in advance might improve their care. The objective of this study was to determine if plasma concentrations of a malaria protein, HRP2 (histidine-rich protein 2) would serve this purpose. Cases and controls were children presenting with uncomplicated malaria; the cases (n = 25) developed cerebral malaria, and the controls (n = 125) did not. Mean plasma HRP2 concentrations were significantly higher in the cases, and an HRP2 cutoff was identified that could predict disease progression (sensitivity and specificity, 88% for each). Quantitative measurements of HRP2 may be a useful screening tool.
authors: Department of Osteopathic Medical Specialties, Michigan State University, East Lansing, MI, USA.
authors: Lindsay L
authors: LL
authors: Fox
authors: Terrie E
authors: TE
authors: Taylor
authors: Paul
authors: P
authors: Pensulo
authors: Alice
authors: A
authors: Liomba
authors: Ashley
authors: A
authors: Mpakiza
authors: Amanda
authors: A
authors: Varela
authors: Simon J
authors: SJ
authors: Glover
authors: Mathew J
authors: MJ
authors: Reeves
authors: Karl B
authors: KB
authors: Seydel
mesh_terms: D000953:Antigens, Protozoan / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D002648:Child; D018450:Disease Progression; D006801:Humans; D016779:Malaria, Cerebral / Q000175:diagnosis*; D016778:Malaria, Falciparum / Q000150:complications*; D008295:Malawi; D010949:Plasma / Q000737:chemistry; D015800:Protozoan Proteins / Q000097:blood*; D012680:Sensitivity and Specificity
chemical_list: D000953:Antigens, Protozoan; D015415:Biomarkers; C514457:HRP-2 antigen, Plasmodium falciparum; D015800:Protozoan Proteins
keywords: HRP2; cerebral malaria; malaria diagnostics
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