title: A randomized controlled trial of the effectiveness of computer-assisted cognitive remediation (CACR) in adolescents with psychosis or at high risk of psychosis.
abstract: BACKGROUND
  Computer assisted cognitive remediation (CACR) was demonstrated to be efficient in improving cognitive deficits in adults with psychosis. However, scarce studies explored the outcome of CACR in adolescents with psychosis or at high risk.
  
  
  OBJECTIVE
  To investigate the effectiveness of a computer-assisted cognitive remediation (CACR) program in adolescents with psychosis or at high risk.
  
  
  METHODS
  Intention to treat analyses included 32 adolescents who participated in a blinded 8-week randomized controlled trial of CACR treatment compared to computer games (CG). Cognitive abilities, symptoms and psychosocial functioning were assessed at baseline and posttreatment.
  
  
  RESULTS
  Improvement in visuospatial abilities was significantly greater in the CACR group than in CG. Other cognitive functions, psychotic symptoms and psychosocial functioning improved significantly, but at similar rates, in the two groups.
  
  
  CONCLUSIONS
  CACR can be successfully administered in this population; it proved to be effective over and above CG for the most intensively trained cognitive ability.
authors: Service Universitaire de Psychiatrie de l'Enfant et de l'Adolescent,Lausanne,Switzerland.
authors: Laurent
authors: L
authors: Holzer
authors: Service Universitaire de Psychiatrie de l'Enfant et de l'Adolescent,Lausanne,Switzerland.
authors: Sebastien
authors: S
authors: Urben
authors: Service Universitaire de Psychiatrie de l'Enfant et de l'Adolescent,Lausanne,Switzerland.
authors: Christina Moses
authors: CM
authors: Passini
authors: Service Universitaire de Psychiatrie de l'Enfant et de l'Adolescent,Lausanne,Switzerland.
authors: Laure
authors: L
authors: Jaugey
authors: Ecole Polytechnique Fédérale de Lausanne (EPFL),Switzerland.
authors: Michael H
authors: MH
authors: Herzog
authors: Service Universitaire de Psychiatrie de l'Enfant et de l'Adolescent,Lausanne,Switzerland.
authors: Olivier
authors: O
authors: Halfon
authors: Service Universitaire de Psychiatrie de l'Enfant et de l'Adolescent,Lausanne,Switzerland.
authors: Sandrine
authors: S
authors: Pihet
mesh_terms: D000293:Adolescent; D003072:Cognition Disorders / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D004311:Double-Blind Method; D006801:Humans; D057194:Intention to Treat Analysis; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011594:Psychometrics; D011618:Psychotic Disorders / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*; D012073:Remedial Teaching; D012307:Risk Factors; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D013813:Therapy, Computer-Assisted / Q000379:methods*