title: New pieces for the substance P puzzle.
authors: Boston Childreńs Hospital, Harvard Medical School, Anesthesia, 300 Longwood Avenue, Boston, MA 02115, USA.
authors: Clas
authors: C
authors: Linnman
mesh_terms: D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000378:metabolism*; D043183:Irritable Bowel Syndrome / Q000378:metabolism*; D008297:Male; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D059265:Visceral Pain / Q000378:metabolism*
chemical_list: D018040:Receptors, Neurokinin-1
references: Agostini A, Benuzzi F, Filippini N, Bertani A, Scarcelli A, Farinelli V, Marchetta C, Calabrese C, Rizzello F, Gionchetti P, Ercolani M, Campieri M, Nichelli P. New insights into the brain involvement in patients with Crohn’s disease: a voxel-based morphometry study. Neurogastroenterol Motil. 2013;25:147-e182.
references: Bergström M, Fasth KJ, Kilpatrick G, Ward P, Cable KM, Wipperman MD, Sutherland DR, Langstrom B. Brain uptake and receptor binding of two [11C] labelled selective high affinity NK1-antagonists, GR203040 and GR205171–PET studies in rhesus monkey. Neuropharmacology. 2000;39:664-670.
references: Bergstrom M, Grahnen A, Langstrom B. Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development. Eur J Clin Pharmacol. 2003;59:357-366.
references: Bergström M, Hargreaves RJ, Burns HD, Goldberg MR, Sciberras D, Reines SA, Petty KJ, Ogren M, Antoni G, Langstrom B, Eskola O, Scheinin M, Solin O, Majumdar AK, Constanzer ML, Battisti WP, Bradstreet TE, Gargano C, Hietala J. Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant. Biol Psychiatry. 2004;55:1007-1012.
references: Borsook D, Upadhyay J, Klimas M, Schwarz AJ, Coimbra A, Baumgartner R, George E, Potter WZ, Large T, Bleakman D, Evelhoch J, Iyengar S, Becerra L, Hargreaves RJ. Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain. Drug Discov Today. 2012;17:964-973.
references: Chen JY, Blankstein U, Diamant NE, Davis KD. White matter abnormalities in irritable bowel syndrome and relation to individual factors. Brain Res. 2011;1392:121-131.
references: George DT, Gilman J, Hersh J, Thorsell A, Herion D, Geyer C, Peng X, Kielbasa W, Rawlings R, Brandt JE, Gehlert DR, Tauscher JT, Hunt SP, Hommer D, Heilig M. Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science. 2008;319:1536-1539.
references: Hargreaves R. Imaging substance P receptors (NK1) in the living human brain using positron emission tomography. J Clin Psychiatry. 2002;63:18-24.
references: Hill R. NK1 (substance P) receptor antagonists–why are they not analgesic in humans? Trends Pharmacol Sci. 2000;21:244-246.
references: Jarcho JM, Feier NA, Bert A, Labus JA, Lee M, Stains J, Ebrat B, Groman SM, Tillisch K, Brody AL, London ED, Mandelkern MA, Mayer EA. Diminished neurokinin-1 receptor availability in patients with two forms of chronic visceral pain. PAIN® 2013;154:987–996.
references: Kennedy PJ, Clarke G, Quigley EM, Groeger JA, Dinan TG, Cryan JF. Gut memories: towards a cognitive neurobiology of irritable bowel syndrome. Neurosci Biobehav Rev. 2012;36:310-340.
references: King T, Vera-Portocarrero L, Gutierrez T, Vanderah TW, Dussor G, Lai J, Fields HL, Porreca F. Unmasking the tonic-aversive state in neuropathic pain. Nat Neurosci. 2009;12:1364-1366.
references: Koch TR, Carney JA, Go VL. Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases. Dig Dis Sci. 1987;32:369-376.
references: Lin CC, Chen WN, Chen CJ, Lin YW, Zimmer A, Chen CC. An antinociceptive role for substance P in acid-induced chronic muscle pain. Proc Natl Acad Sci USA. 2012;109:E76-83.
references: Linnman C, Appel L, Furmark T, Soderlund A, Gordh T, Langstrom B, Fredrikson M. Ventromedial prefrontal neurokinin 1 receptor availability is reduced in chronic pain. PAIN®. 2010;149:64-70.
references: Mantyh PW, Allen CJ, Ghilardi JR, Rogers SD, Mantyh CR, Liu H, Basbaum AI, Vigna SR, Maggio JE. Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. Proc Natl Acad Sci USA. 1995;92:2622-2626.
references: Michelgard A, Appel L, Pissiota A, Frans O, Langstrom B, Bergstrom M, Fredrikson M. Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system. Biol Psychiatry. 2007;61:1002-1006.
references: Saji K, Ikeda Y, Kim W, Shingai Y, Tateno A, Takahashi H, Okubo Y, Fukayama H, Suzuki H. Acute NK1 receptor antagonist administration affects reward incentive anticipation processing in healthy volunteers. Int J Neuropsychopharmacol. 2013;1-11.
references: Snider RM, Constantine JW, Lowe JA 3rd, Longo KP, Lebel WS, Woody HA, Drozda SE, Desai MC, Vinick FJ, Spencer RW, et al. A potent nonpeptide antagonist of the substance P (NK1) receptor. Science. 1991;251:435-437.
references: Tregear GW, Niall HD, Potts JT Jr, Leeman SE, Chang MM. Synthesis of substance P. Nat New Biol. 1971;232:87-89.
references: Upadhyay J, Anderson J, Schwarz AJ, Coimbra A, Baumgartner R, Pendse G, George E, Nutile L, Wallin D, Bishop J, Neni S, Maier G, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Becerra L, Borsook D. Imaging drugs with and without clinical analgesic efficacy. Neuropsychopharmacology. 2011;36:2659-2673.
references: van der Hart MG, Czeh B, de Biurrun G, Michaelis T, Watanabe T, Natt O, Frahm J, Fuchs E. Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume. Mol Psychiatry. 2002;7:933-941.
references: Von Euler US, Gaddum JH. An unidentified depressor substance in certain tissue extracts. J Physiol. 1931;72:74-87.
references: Wicksell RK, Ahlqvist J, Bring A, Melin L, Olsson GL. Can exposure and acceptance strategies improve functioning and life satisfaction in people with chronic pain and Whiplash-Associated Disorders (WAD)? A randomized controlled trial. Cogn Behav Ther. 2008;1-14.
references: Yu YJ, Arttamangkul S, Evans CJ, Williams JT, von Zastrow M. Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons. J Neurosci. 2009;29:222-233.