title: Chirality-Mediated Mechanical and Structural Properties of Oligopeptide Hydrogels.
abstract: The origin and the effects of homochirality in the biological world continuously stimulate numerous hypotheses and much debate. This work attempts to look at the biohomochirality issue from a different angle-the mechanical properties of the bulk biomaterial and their relation to nanoscale structures. Using a pair of oppositely charged peptides that co-assemble into hydrogels, we systematically investigated the effect of chirality on the mechanical properties of these hydrogels through different combinations of syndiotactic and isotactic peptides. It was found that homochirality confers mechanical advantage, resulting in higher elastic modulus and strain yield value. Yet, heterochirality confer kinetic advantage, resulting in faster gelation. Structurally, both homochiral and heterochiral hydrogels are made of fibers interconnected by lappet-like webs, but the homochiral peptide fibers are thicker and denser. The result highlights the possible role of biohomochirality in the evolution and/or natural selection of biomaterials.
authors: Fischell Department of Bioengineering, University of Maryland, College Park, USA.
authors: Marc B
authors: MB
authors: Taraban
authors: Yue
authors: Y
authors: Feng
authors: Boualem
authors: B
authors: Hammouda
authors: Laura L
authors: LL
authors: Hyland
authors: Y Bruce
authors: YB
authors: Yu
keywords: NMR spectroscopy; dynamic rheometry; heterochirality; homochirality; hydrogels; mechanical properties; small-angle X-ray scattering; small-angle neutron scattering
references: Chemistry. 2007;13(8):2180-8
references: 17245789
references: J Phys Chem B. 2009 Dec 24;113(51):16435-42
references: 19947575
references: Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18360-5
references: 19011110
references: Biomacromolecules. 2005 May-Jun;6(3):1316-21
references: 15877347
references: Prog Biophys Mol Biol. 2005 Sep;89(1):1-8
references: 15826671
references: Biopolymers. 1999 May;49(6):505-14
references: 10193196
references: J Mol Model. 2006 Mar;12(4):462-7
references: 16437209
references: Nature. 1984 Aug 16-22;310(5978):602-4
references: 6462250
references: J Control Release. 2001 May 14;72(1-3):47-56
references: 11389984
references: Nature. 2001 Feb 15;409(6822):797-801
references: 11236988
references: ChemMedChem. 2009 Sep;4(9):1488-94
references: 19591190
references: Acc Chem Res. 2009 Aug 18;42(8):1128-40
references: 19480407
references: Adv Drug Deliv Rev. 2003 Apr 25;55(4):549-83
references: 12706050
references: Biopolymers. 1999 Aug;50(2):201-9
references: 10380344
references: C R Biol. 2011 Apr;334(4):269-72
references: 21513895
references: Protein Sci. 2007 Aug;16(8):1667-75
references: 17600146
references: Chem Commun (Camb). 2001 Sep 7;(17):1556-7
references: 12240379
references: Chem Commun (Camb). 2010 Jan 28;46(4):522-37
references: 20062853
references: J Am Chem Soc. 2004 Oct 20;126(41):13194-5
references: 15479052
references: Beilstein J Org Chem. 2010 Oct 04;6:945-59
references: 21085503
references: J Biol Chem. 2003 Sep 12;278(37):34874-81
references: 12840031
references: Phys Rev Lett. 1995 Dec 11;75(24):4425-4428
references: 10059905
references: Cold Spring Harb Perspect Biol. 2010 May;2(5):a002147
references: 20452962
references: J Am Chem Soc. 2004 Mar 31;126(12):3762-8
references: 15038729
references: Science. 1992 Jun 5;256(5062):1445-8
references: 1604320
references: J Pept Sci. 1997 Jul-Aug;3(4):299-313
references: 9262649
references: Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11435-42
references: 8876153
references: Nat Mater. 2003 Nov;2(11):715-25
references: 14593396
references: Biophys J. 1999 Jun;76(6):2879-86
references: 10354416
references: Biochemistry. 2005 Jan 11;44(1):157-64
references: 15628856
references: Orig Life Evol Biosph. 2010 Feb;40(1):111-8
references: 19911302
references: Nat Chem. 2009 Jul;1(4):326-31
references: 20703363
references: Biopolymers. 2012 Mar;97(3):177-88
references: 21994046
references: Biomacromolecules. 2006 Oct;7(10):2790-5
references: 17025354
references: Chemistry. 2005 Sep 5;11(18):5353-61
references: 16003819
references: Top Curr Chem. 2005;256:167-218
references: 22160339
references: Chemistry. 2004 Nov 19;10(23):5901-10
references: 15472938
references: Soft Matter. 2011;7(21):9890-9893
references: 22287979
references: Biomaterials. 2002 Nov;23(22):4389-96
references: 12219829
references: Methods Mol Biol. 2009;544:307-23
references: 19488708
references: J Am Chem Soc. 2007 Aug 15;129(32):9918-26
references: 17645336
references: Acc Chem Res. 2008 Oct;41(10):1301-8
references: 18642934
references: Anal Biochem. 1989 Nov 1;182(2):319-26
references: 2610349
references: J Am Chem Soc. 2011 Sep 28;133(38):14975-7
references: 21863803