title: Mouse models uncap novel roles of SSBs.
abstract: Three recently published reports, including one in Cell Research, generated Ssb1 knockout mice and demonstrated critical roles of this protein in regulating skeletogenesis, telomere homeostasis and tumor suppression.
authors: Queensland Institute of Medical Research, Herston, Australia.
authors: Amanda L
authors: AL
authors: Bain
authors: Wei
authors: W
authors: Shi
authors: Kum Kum
authors: KK
authors: Khanna
mesh_terms: D000818:Animals; D064007:Ataxia Telangiectasia Mutated Proteins / Q000378:metabolism; D002460:Cell Line; D004260:DNA Repair; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D034622:RNA Interference; D034741:RNA, Small Interfering; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics / Q000378:metabolism*; D059505:Telomere Homeostasis / Q000502:physiology*
chemical_list: D034741:RNA, Small Interfering; C515022:SSB-1 protein, mouse; D050826:Suppressor of Cytokine Signaling Proteins; D064007:Ataxia Telangiectasia Mutated Proteins; C576325:Atm protein, mouse
references: J Cell Biol. 2009 Oct 5;187(1):25-32
references: 19786574
references: Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2431-6
references: 20133760
references: J Biol Chem. 2009 Aug 28;284(35):23525-31
references: 19605351
references: Nucleic Acids Res. 2011 May;39(9):3643-51
references: 21227926
references: EMBO J. 2013 Jan 9;32(1):126-39
references: 23178594
references: Cell Res. 2013 May;23(5):705-19
references: 23459151
references: Mutat Res. 2012 Feb 1;730(1-2):12-9
references: 21945241
references: J Biol Chem. 2009 Oct 30;284(44):30408-15
references: 19759019
references: EMBO J. 2012 Oct 17;31(20):4045-56
references: 22940690
references: Mol Cell. 2009 Aug 14;35(3):384-93
references: 19683501
references: PLoS Genet. 2013;9(2):e1003298
references: 23408915
references: Nature. 2008 May 29;453(7195):677-81
references: 18449195
references: Cell Res. 2013 Mar;23(3):423-35
references: 23184057