title: Ongoing adaptive immune responses in the microenvironment of melanoma metastases.
abstract: A large body of evidence supports the idea that the tumor environment is immunosuppressive, notably for T lymphocytes. Yet, in some tumor types, the presence of tumor-infiltrating T cells has favorable prognostic value. In order to better understand the functional value of T cells in human tumors, we focused on cutaneous metastases of melanoma and observed that some of them host ectopic lymphoid structures in which B cell, and possibly T cell, responses take place. This observation is discussed in the context of current views on immunosuppression in tumors.
authors: Ludwig Institute for Cancer Research Ltd., Brussels, Belgium. nicolas.vanbaren@bru.licr.org
authors: Nicolas
authors: N
authors: van Baren
authors: Pierre G
authors: PG
authors: Coulie
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D006801:Humans; D056724:Immunity, Humoral; D007070:Immunoglobulin A / Q000276:immunology; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D008545:Melanoma / Q000276:immunology* / Q000473:pathology*; D051379:Mice; D009362:Neoplasm Metastasis; D011379:Prognosis; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology*
chemical_list: D007070:Immunoglobulin A; D007166:Immunosuppressive Agents