title: Tricycles by a new Ugi variation and Pictet-Spengler reaction in one pot.
abstract: Subsequent mild cyclization of aromatic substrates by Pictet-Spengler condensation stereoselectively gave new tricyclic compounds. Examples are described in decent yields over two steps in one pot, and a crystal structure is also presented to support the proposed structures.
authors: Department of Pharmaceutical Science, University of Pittsburgh, BST-3, 3501 Fifth Ave, Pittsburgh, PA, USA.
authors: Mantosh K
authors: MK
authors: Sinha
authors: Kareem
authors: K
authors: Khoury
authors: Eberhardt
authors: E
authors: Herdtweck
authors: Alexander
authors: A
authors: Dömling
mesh_terms: D003500:Cyclization; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D006575:Heterocyclic Compounds, 3-Ring; D007546:Isoquinolines
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