title: Tumor marker levels in patients aged 85 years and older with chronic heart failure.
abstract: BACKGROUND
  Recent studies have suggested that carbohydrate antigen 125 (CA 125) serum levels are remarkably elevated in patients with heart failure. We hypothesized that there was a relationship between serum levels of tumor markers and the four stages of chronic heart failure (CHF) in patients aged 85 years and older with CHF.
  
  
  METHODS
  The retrospective study enrolled 2115 patients aged 85 years and older suffering from CHF between January 2004 and January 2011. The levels of various tumor markers, N-terminal proB-type natriuretic peptide (NT-proBNP) in the different stages of CHF, and clinical risk factors were analyzed. All patients were followed for 180 days, and major cardiovascular events were recorded.
  
  
  RESULTS
  Only the CA 125 level increased as the stage of CHF increased (p<0.05) among the tumor markers. Significantly higher CA 125 serum levels were found in patients with pleural fluids or peripheral edema, compared with patients without pericardial effusion or peripheral edema (p<0.01). During 180 days of follow-up, CA 125 values were significantly higher in patients who died or were rehospitalized, compared with those who remained alive or did not undergo rehospitalization. Linear regression analysis between CA 125 and NT-proBNP serum levels showed a statistically significant relation (r=0.5103, p<0.05).
  
  
  CONCLUSIONS
  Among the tumor markers evaluated, only CA 125 appeared to be related to the severity of CHF and NT-proBNP, along with the presence of pleural fluid or peripheral edema in patients aged 85 years and older with CHF.
authors: First Geriatric Cardiology Division of South Building, Chinese PLA General Hospital, Beijing, China.
authors: Jinling
authors: J
authors: Ma
authors: Yuexiang
authors: Y
authors: Zhao
authors: Yutang
authors: Y
authors: Wang
authors: Yuanyuan
authors: Y
authors: Guo
authors: Jian
authors: J
authors: Li
mesh_terms: D000367:Age Factors; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018394:CA-125 Antigen / Q000378:metabolism*; D002908:Chronic Disease; D004487:Edema / Q000378:metabolism; D005260:Female; D006333:Heart Failure / Q000378:metabolism*; D006801:Humans; D016014:Linear Models; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D010996:Pleural Effusion / Q000378:metabolism; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain