title: Genetic variation of the CYP17 and susceptibility to endometrial cancer: a meta-analysis.
abstract: Excessive estrogenic influence is known to be associated with initiation/promotion of endometrial cancer (EC). Common variants among genes coding for enzymes in sex steroid biosynthetic pathways may influence the risk of EC. Cytochrome P450c17α (CYP17), a gene that codes for a key enzyme (cytochrome P450c17α) in a rate-limiting step of estrogen biosynthesis has attracted considerable attention as a candidate gene for EC. The relationship between CYP17 and EC has been reported in various ethnic groups; however, these studies have yielded contradictory results. To investigate this inconsistency, we performed a meta-analysis of 13 studies involving a total of 3,258 cases and 4,614 controls for -34T>C (rs743572) polymorphism of the CYP17 gene to evaluate the effect of CYP17 on genetic susceptibility for EC. An overall random effects odds ratio of 0.71 (95% confidence interval 0.58-0.88, P=0.001) was found under recessive genetic model. Stratified analysis based on ethnicity, sample size and Hardy-Weinberg equilibrium status was conducted to explore potential heterogeneity. This meta-analysis demonstrated that the C allele of -34T>C in CYP17 is a protective factor associated with decreased EC susceptibility, but these associations vary in different ethnic populations.
authors: Department of Gynaecology and Obstetrics, Shanghai Minhang District Center Hospital, 285 Xindong Road, Shanghai, 201100, People's Republic of China. superjun_xu@126.com
authors: Jun
authors: J
authors: Xu
authors: Xiao
authors: X
authors: Lin
authors: Haoping
authors: H
authors: Zhu
authors: Zhiling
authors: Z
authors: Zhang
authors: Baohua
authors: B
authors: Yang
mesh_terms: D016889:Endometrial Neoplasms / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D008957:Models, Genetic; D016017:Odds Ratio; D039781:PubMed; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*
chemical_list: D013254:Steroid 17-alpha-Hydroxylase
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