title: Are bilateral breast cancers different from breast cancers coexisting with ovarian cancer? An immunohistochemical analysis aimed at intrinsic tumor phenotype.
abstract: BACKGROUND
  Bilateral breast cancers (BBC) and breast cancers coexisting with ovarian cancer (BOCS) are associated with genetic predisposition more frequently than sporadic cases. We compared the phenotypes of these tumors to better understand their pathomechanisms and aid the guiding of their clinical management.
  
  
  METHODS
  Tumor morphology and expression of ER, PgR, HER2, Ki67, CK5/6, E-cadherin, vimentin and EGFR were assessed in a tissue microarray containing cores from 174 BBC, 23 BOCS and 2 BBC + BOCS.
  
  
  RESULTS
  BOCS tumors were characterized by higher incidence of EGFR expression, HER2 negativity and lower incidence of intraductal component. HER2-positive phenotypes were marginally more frequent in the BBC group and triple negative tumors - in BOCS.
  
  
  CONCLUSIONS
  Breast cancers from BOCS patients are characterized by more aggressive phenotype, most probably related to their more frequent association with BRCA1 mutation.
authors: Department of Oncology & Radiotherapy, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland. elsenkus@gumed.edu.pl
authors: Elżbieta
authors: E
authors: Senkus
authors: Jolanta
authors: J
authors: Szade
authors: Beata
authors: B
authors: Pieczyńska
authors: Anna
authors: A
authors: Żaczek
authors: Izabela
authors: I
authors: Brożek
authors: Barbara
authors: B
authors: Radecka
authors: Anna
authors: A
authors: Kowalczyk
authors: Marzena
authors: M
authors: Wełnicka-Jaśkiewicz
authors: Jacek
authors: J
authors: Jassem
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D015820:Cadherins / Q000378:metabolism; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053555:Keratin-5 / Q000378:metabolism; D053553:Keratin-6 / Q000378:metabolism; D019394:Ki-67 Antigen / Q000378:metabolism; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000378:metabolism* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D010641:Phenotype; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D046888:Tissue Array Analysis; D014746:Vimentin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D053555:Keratin-5; D053553:Keratin-6; D019394:Ki-67 Antigen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D014746:Vimentin; C512478:EGFR protein, human; D066246:ErbB Receptors