title: Roles of lipid metabolism in keloid development.
abstract: Keloids are common cutaneous pathological scars that are characterised by the histological accumulation of fibroblasts, collagen fibres, and clinically significant invasive growth. Although increasing lines of research on keloids have revealed genetic and environmental factors that contribute to their formation, the etiology of these scars remains unclear. Several studies have suggested the involvement of lipid metabolism, from a nutritional point of view. However, the role that lipid metabolism plays in the pathogenesis and progression of keloids has not previously been reviewed. The progress that has been made in understanding the roles of the pro- and anti-inflammatory lipid mediators in inflammation, and how they relate to the formation and progression of keloids, is also outlined. In particular, the possible relationships between mechanotransduction and lipid metabolites in keloids are explored. Mechanotransduction is the process by which physical forces are converted into biochemical signals that are then integrated into cellular responses. It is possible that lipid rafts and caveolae provide the location of lipid signaling and interactions between these signaling pathways and mechanotransduction. Moreover, interactions between lipid signaling pathway molecules and mechanotransduction molecules have been observed. A better understanding of the lipid profile changes and the functional roles lipid metabolism plays in keloids will help to identify target molecules for the development of novel interventions that can prevent, reduce, or even reverse pathological scar formation and/or progression.
authors: Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, 1-1-5 Sendagi Bunkyo-ku, Tokyo 113-8603, Japan.
authors: Chenyu
authors: C
authors: Huang
authors: Rei
authors: R
authors: Ogawa
mesh_terms: D002921:Cicatrix / Q000378:metabolism / Q000473:pathology; D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000473:pathology; D007627:Keloid / Q000378:metabolism* / Q000503:physiopathology; D050356:Lipid Metabolism; D040542:Mechanotransduction, Cellular / Q000502:physiology; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D016212:Transforming Growth Factor beta
references: Connect Tissue Res. 2012;53(3):187-96
references: 22329637
references: Br J Plast Surg. 1990 Mar;43(2):183-6
references: 2328380
references: Annu Rev Immunol. 2007;25:101-37
references: 17090225
references: Arterioscler Thromb. 1994 Nov;14(11):1829-36
references: 7524649
references: Am J Physiol Cell Physiol. 2004 Jul;287(1):C1-11
references: 15189819
references: Prostaglandins Leukot Essent Fatty Acids. 1997 Oct;57(4-5):353-7
references: 9430378
references: J Biol Chem. 1995 Feb 3;270(5):2047-52
references: 7836432
references: Arch Dermatol Res. 1997 Feb;289(3):164-9
references: 9128765
references: J Immunol. 2009 May 1;182(9):5374-81
references: 19380784
references: Biochem Biophys Res Commun. 2007 Jun 29;358(2):626-31
references: 17498653
references: J Nippon Med Sch. 2011;78(2):68-76
references: 21551963
references: FASEB J. 2011 Sep;25(9):2967-79
references: 21628447
references: J Biol Chem. 1986 Jul 5;261(19):8597-600
references: 3013856
references: Kidney Int. 2004 Apr;65(4):1145-54
references: 15086453
references: Am J Dermatopathol. 2004 Oct;26(5):379-84
references: 15365369
references: Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8443-7
references: 7545303
references: Exp Dermatol. 2008 Apr;17(4):318-23
references: 17979971
references: Ann Med. 2003;35(8):564-77
references: 14708967
references: Am J Physiol Cell Physiol. 2004 Apr;286(4):C831-9
references: 14644772
references: J Immunol. 2003 Dec 15;171(12):6856-65
references: 14662892
references: Adv Exp Med Biol. 1997;400B:905-10
references: 9547645
references: Wound Repair Regen. 2012 Mar-Apr;20(2):149-57
references: 22332721
references: Int Wound J. 2014 Oct;11(5):517-22
references: 23173565
references: J Invest Dermatol. 2000 Dec;115(6):1065-71
references: 11121143
references: J Surg Res. 2002 Sep;107(1):135-9
references: 12384076
references: Prostaglandins Leukot Essent Fatty Acids. 2000 Nov;63(5):255-62
references: 11090251
references: Annu Rev Med. 1990;41:187-98
references: 2139553
references: Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9
references: 11413487
references: J Invest Dermatol. 2004 May;122(5):1126-32
references: 15140214
references: Science. 1999 Feb 26;283(5406):1317-21
references: 10037600
references: Nat Immunol. 2001 Jul;2(7):612-9
references: 11429545
references: Cytokine. 2002 Dec 7;20(5):215-23
references: 12550106
references: Br J Dermatol. 2011 Mar;164(3):623-7
references: 21375514
references: Burns. 2006 May;32(3):299-304
references: 16487663
references: Wound Repair Regen. 2007 Jan-Feb;15(1):122-33
references: 17244328
references: Cell. 1995 Jun 16;81(6):917-24
references: 7781068
references: Med Hypotheses. 2002 Apr;58(4):264-9
references: 12027517
references: Med Hypotheses. 2008;71(1):32-8
references: 18406540
references: J Invest Dermatol. 2003 Mar;120(3):456-64
references: 12603860
references: Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H936-45
references: 15471980
references: J Invest Dermatol. 2006 May;126(5):990-7
references: 16528361
references: Nat Rev Neurosci. 2007 Feb;8(2):128-40
references: 17195035
references: Br J Dermatol. 2011 Apr;164(4):729-37
references: 21070203
references: J Pathol. 2012 Dec;228(4):506-19
references: 22610993
references: Oral Dis. 2004 Mar;10(2):87-93
references: 14996278
references: Adv Exp Med Biol. 1997;400B:589-97
references: 9547608
references: J Biol Chem. 1998 Nov 27;273(48):32304-11
references: 9822710
references: Prostaglandins Leukot Essent Fatty Acids. 2000 Nov;63(5):237-45
references: 11090249
references: J Biol Chem. 2001 May 11;276(19):15741-6
references: 11278818
references: Plast Reconstr Surg. 2007 May;119(6):1714-1721
references: 17440345
references: Ann Rheum Dis. 2012 Jun;71(6):1081-7
references: 22267335
references: Med Hypotheses. 2008 Oct;71(4):493-500
references: 18614294
references: Int Arch Allergy Immunol. 2007;143 Suppl 1:15-22
references: 17541271
references: Prostaglandins Leukot Essent Fatty Acids. 2000 Nov;63(5):247-53
references: 11090250