title: Chromatin organization and global regulation of Hox gene clusters.
abstract: During development, a properly coordinated expression of Hox genes, within their different genomic clusters is critical for patterning the body plans of many animals with a bilateral symmetry. The fascinating correspondence between the topological organization of Hox clusters and their transcriptional activation in space and time has served as a paradigm for understanding the relationships between genome structure and function. Here, we review some recent observations, which revealed highly dynamic changes in the structure of chromatin at Hox clusters, in parallel with their activation during embryonic development. We discuss the relevance of these findings for our understanding of large-scale gene regulation.
authors: National Research Centre 'Frontiers in Genetics', School of Life Sciences, Ecole Polytechnique Fédérale, Lausanne, Switzerland.
authors: Thomas
authors: T
authors: Montavon
authors: Denis
authors: D
authors: Duboule
mesh_terms: D000818:Animals; D019521:Body Patterning; D042002:Chromatin Assembly and Disassembly; D047108:Embryonic Development; D044127:Epigenesis, Genetic; D005121:Extremities / Q000196:embryology; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D006657:Histones / Q000378:metabolism; D006801:Humans; D005810:Multigene Family; D012045:Regulatory Sequences, Nucleic Acid; D015533:Transcriptional Activation
chemical_list: D006657:Histones
keywords: chromatin architecture; collinearity; embryonic patterning; long-range regulation; nuclear organization
references: Genes Dev. 2001 Sep 1;15(17):2209-14
references: 11544178
references: Curr Opin Genet Dev. 2012 Apr;22(2):110-4
references: 22365496
references: Genes Dev. 1991 Oct;5(10):1767-7
references: 1680771
references: Development. 2006 Feb;133(4):761-72
references: 16407397
references: Nucleic Acids Res. 2010 Nov;38(21):7472-84
references: 20660483
references: Nature. 2002 Nov 14;420(6912):145-50
references: 12432383
references: Dev Dyn. 1998 Sep;213(1):1-11
references: 9733096
references: Development. 2012 Mar;139(5):929-39
references: 22278926
references: Science. 2009 Jun 5;324(5932):1320-3
references: 19498168
references: Science. 2009 Oct 9;326(5950):289-93
references: 19815776
references: Mol Cell. 2007 Jan 12;25(1):15-30
references: 17218268
references: Nat Biotechnol. 2010 Oct;28(10):1089-95
references: 20944601
references: Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21931-6
references: 21106759
references: Nature. 2004 Sep 2;431(7004):67-71
references: 15343333
references: Dev Cell. 2004 Nov;7(5):663-76
references: 15525528
references: Development. 2009 May;136(10):1665-74
references: 19369396
references: Development. 2007 Jan;134(2):223-32
references: 17185323
references: Nature. 1978 Dec 7;276(5688):565-70
references: 103000
references: Science. 2002 Nov 1;298(5595):1039-43
references: 12351676
references: PLoS Genet. 2010 Dec 09;6(12):e1001244
references: 21170310
references: Nature. 2004 Oct 14;431(7010):873-8
references: 15386022
references: Science. 2007 Oct 19;318(5849):447-50
references: 17761849
references: Dev Cell. 2010 Dec 14;19(6):819-30
references: 21145498
references: Development. 1996 May;122(5):1449-66
references: 8625833
references: Curr Top Dev Biol. 2009;88:1-33
references: 19651300
references: Genome Biol. 2009;10(4):R37
references: 19374771
references: Nature. 2007 Oct 11;449(7163):689-94
references: 17851529
references: Genes Dev. 2008 Feb 1;22(3):346-59
references: 18245448
references: Cell. 2006 Apr 21;125(2):301-13
references: 16630818
references: Genes Dev. 2006 May 1;20(9):1123-36
references: 16618801
references: Nat Cell Biol. 2006 May;8(5):532-8
references: 16570078
references: Dev Cell. 2006 Jan;10(1):93-103
references: 16399081
references: Development. 2005 May;132(9):2215-23
references: 15829525
references: PLoS Genet. 2007 Dec;3(12):e232
references: 18159948
references: Curr Opin Genet Dev. 2007 Aug;17(4):359-66
references: 17644373
references: Curr Biol. 2010 Sep 14;20(17):1562-7
references: 20797865
references: Cell. 2002 Oct 18;111(2):197-208
references: 12408864
references: Cell. 2011 Nov 23;147(5):1132-45
references: 22118467
references: Genes Dev. 2002 Nov 15;16(22):2893-905
references: 12435631
references: PLoS Genet. 2008 Oct;4(10):e1000242
references: 18974828
references: Cell. 2007 Sep 21;130(6):1083-94
references: 17825402
references: Cell. 2007 Jun 29;129(7):1311-23
references: 17604720
references: Science. 2003 Oct 17;302(5644):413
references: 14563999
references: Genes Dev. 1998 Jan 1;12(1):11-20
references: 9420327
references: Cell. 2006 Apr 21;125(2):315-26
references: 16630819
references: Cell. 2011 Jan 21;144(2):214-26
references: 21241892
references: Proc Natl Acad Sci U S A. 2011 May 3;108(18):7391-6
references: 21502535
references: Nat Rev Genet. 2007 Jan;8(1):9-22
references: 17173055
references: Science. 2011 Oct 14;334(6053):222-5
references: 21998387
references: Mol Cell. 2010 May 14;38(3):452-64
references: 20471950
references: PLoS Genet. 2009 Mar;5(3):e1000398
references: 19266017
references: Cell. 2002 Oct 18;111(2):185-96
references: 12408863
references: Cell. 2010 Jan 8;140(1):99-110
references: 20085705
references: Nature. 2011 Apr 7;472(7341):120-4
references: 21423168
references: Genes Dev. 2011 Oct 15;25(20):2210-21
references: 22012622
references: Cell. 2003 May 2;113(3):405-17
references: 12732147
references: Nature. 2012 Aug 16;488(7411):409-13
references: 22801502
references: Nat Genet. 2005 Aug;37(8):889-93
references: 15995706
references: Nature. 2012 Sep 6;489(7414):57-74
references: 22955616
references: Nature. 2011 Feb 10;470(7333):279-83
references: 21160473
references: Dev Biol. 2011 Mar 15;351(2):288-96
references: 21195707
references: Genes Dev. 2003 Aug 1;17(15):1823-8
references: 12897052
references: Cell. 1989 May 5;57(3):367-78
references: 2566383
references: Nature. 2010 Jul 22;466(7305):490-3
references: 20512118
references: Birth Defects Res A Clin Mol Teratol. 2011 Aug;91(8):781-7
references: 21290568
references: Dev Cell. 2010 Apr 20;18(4):526-32
references: 20412768
references: Nat Genet. 2007 Mar;39(3):311-8
references: 17277777
references: Nat Commun. 2011;2:310
references: 21556064
references: Dev Biol. 2007 Jun 15;306(2):847-59
references: 17448461
references: Development. 2012 Sep;139(17):3157-67
references: 22872084
references: EMBO J. 1989 May;8(5):1497-505
references: 2569969
references: Genes Dev. 2003 Aug 1;17(15):1870-81
references: 12897054
references: Genes Dev. 2012 Jan 1;26(1):11-24
references: 22215806
references: Nature. 2006 May 18;441(7091):349-53
references: 16625203
references: Nature. 2012 Apr 11;485(7398):376-80
references: 22495300
references: Dev Biol. 2010 Aug 1;344(1):7-15
references: 20435029
references: Genes Dev. 2004 May 15;18(10):1119-30
references: 15155579
references: Cell. 1996 Jun 28;85(7):1025-35
references: 8674109
references: Science. 2008 Sep 5;321(5894):1314
references: 18772429
references: EMBO J. 1991 Aug;10(8):2279-89
references: 1676674
references: Annu Rev Genet. 2011;45:145-66
references: 22060042
references: Cell. 2005 Jan 28;120(2):169-81
references: 15680324
references: PLoS Genet. 2011 May;7(5):e1002071
references: 21637793
references: Nat Cell Biol. 2007 Oct;9(10):1167-74
references: 17828248
references: Dev Cell. 2009 Oct;17(4):516-26
references: 19853565
references: Nature. 1989 Dec 14;342(6251):767-72
references: 2574828
references: Nat Rev Genet. 2011 Jan;12(1):7-18
references: 21116306
references: Cell Stem Cell. 2010 Sep 3;7(3):288-98
references: 20804966
references: Proc Natl Acad Sci U S A. 2006 May 2;103(18):6994-9
references: 16636282
references: Development. 2007 Jul;134(14):2549-60
references: 17553908
references: Cell. 2012 Feb 3;148(3):458-72
references: 22265598