title: Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies.
abstract: Traumatic brain injury (TBI) is a serious problem that affects millions of people in the United States alone. Multiple concussions or even a single moderate to severe TBI can also predispose individuals to develop a pathologically distinct form of tauopathy-related dementia at an early age. No effective treatments are currently available for TBI or TBI-related dementia; moreover, only recently has insight been gained regarding the mechanisms behind their connection. Here, we used antibodies to detect oligomeric and phosphorylated Tau proteins in a non-transgenic rodent model of parasagittal fluid percussion injury. Oligomeric and phosphorylated Tau proteins were detected 4 and 24 h and 2 weeks post-TBI in injured, but not sham control rats. These findings suggest that diagnostic tools and therapeutics that target only toxic forms of Tau may provide earlier detection and safe, more effective treatments for tauopathies associated with repetitive neurotrauma.
authors: Sealy Center for Vaccine Development University of Texas Medical Branch, Galveston, Texas 77555; Moody Center for Traumatic Brain & Spinal Cord Injury Research, University of Texas Medical Branch, Galveston, Texas 77555; Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555.
authors: Bridget E
authors: BE
authors: Hawkins
authors: Departments of Neurology and Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555; George and Cynthia Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas 77555-1045.
authors: Shashirekha
authors: S
authors: Krishnamurthy
authors: Departments of Neurology and Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555; George and Cynthia Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas 77555-1045.
authors: Diana L
authors: DL
authors: Castillo-Carranza
authors: Departments of Neurology and Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555; George and Cynthia Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas 77555-1045.
authors: Urmi
authors: U
authors: Sengupta
authors: Moody Center for Traumatic Brain & Spinal Cord Injury Research, University of Texas Medical Branch, Galveston, Texas 77555; Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555.
authors: Donald S
authors: DS
authors: Prough
authors: Sealy Center for Vaccine Development University of Texas Medical Branch, Galveston, Texas 77555; Departments of Neurology and Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555; George and Cynthia Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas 77555-1045.
authors: George R
authors: GR
authors: Jackson
authors: Moody Center for Traumatic Brain & Spinal Cord Injury Research, University of Texas Medical Branch, Galveston, Texas 77555; Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas 77555.
authors: Douglas S
authors: DS
authors: DeWitt
authors: Sealy Center for Vaccine Development University of Texas Medical Branch, Galveston, Texas 77555; Departments of Neurology and Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555; George and Cynthia Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas 77555-1045. Electronic address: rakayed@utmb.edu.
authors: Rakez
authors: R
authors: Kayed
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D015170:Cerebrospinal Fluid Pressure; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D010766:Phosphorylation; D055503:Protein Multimerization; D051381:Rats; D017207:Rats, Sprague-Dawley; D024801:Tauopathies / Q000209:etiology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D016875:tau Proteins / Q000378:metabolism*
chemical_list: C489131:Mapt protein, rat; D016875:tau Proteins
keywords: Neurodegeneration; Protein Aggregation; Protein Assembly; Protein Misfolding; Tau; Tau Aggregation; Tau Oligomers; Tauopathies; Traumatic Brain Injury
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