title: Fine-tuning evolution: germ-line epigenetics and inheritance.
abstract: In mice, epiblast cells found both the germ-line and somatic lineages in the developing embryo. These epiblast cells carry epigenetic information from both parents that is required for development and cell function in the fetus and during post-natal life. However, germ cells must establish an epigenetic program that supports totipotency and the configuration of parent-specific epigenetic states in the gametes. To achieve this, the epigenetic information inherited by the primordial germ cells at specification is erased and new epigenetic states are established during development of the male and female germ-lines. Errors in this process can lead to transmission of epimutations through the germ-line, which have the potential to affect development and disease in the parent's progeny. This review discusses epigenetic reprogramming in the germ-line and the transmission of epigenetic information to the following generation.
authors: Germ Cell Development and Epigenetics Laboratory, Centre for Reproduction and Development, Monash Institute of Medical Research, 27-31 Wright Street, Clayton, Victoria 3168, Australia.
authors: Jessica M
authors: JM
authors: Stringer
authors: Sanna
authors: S
authors: Barrand
authors: Patrick
authors: P
authors: Western
mesh_terms: D000818:Animals; D005075:Biological Evolution; D047108:Embryonic Development; D044127:Epigenesis, Genetic; D057890:Epigenomics; D005854:Germ Cells / Q000502:physiology*; D006801:Humans