title: ROS kinase fusions are not common in Chinese patients with cholangiocarcinoma.
abstract: OBJECTIVE
  To investigate the expressions of different forms of ROS fusions in Chinese patients with cholangiocarcinoma (CCA).
  
  
  METHODS
  RT-PCR was employed to examine formalin-fixed and paraffin-embedded CCA samples from stage I-IV patients for detection of ROS fusions involving Fused in Glioblastoma (FIG), solute carrier protein (SLC34A2) and major histocompatibility complex class II invariant chain (CD74). Serpin peptidase inhibitor clade A member 1 (SERPINA1) was detected as the reference gene.
  
  
  RESULTS
  In all the 56 CCA samples, 80.4% (45/56) were positive for SERPINA1 expression as evaluable samples. Of these evaluable samples, none expressed the ROS fusions.
  
  
  CONCLUSIONS
  ROS fusions are not common in Chinese CCA patients.
authors: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. pengmin_123456@126.com
authors: Pengmin
authors: P
authors: Liu
authors: Yajun
authors: Y
authors: Wu
authors: Li
authors: L
authors: Sun
authors: Qiang
authors: Q
authors: Zuo
authors: Min
authors: M
authors: Shi
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000944:Antigens, Differentiation, B-Lymphocyte / Q000235:genetics / Q000378:metabolism; D001650:Bile Duct Neoplasms / Q000378:metabolism* / Q000473:pathology; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D018281:Cholangiocarcinoma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D000077614:Golgi Matrix Proteins; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D026901:Membrane Transport Proteins; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism*; D016612:Paraffin Embedding; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D050614:Sodium-Phosphate Cotransporter Proteins, Type IIb / Q000235:genetics / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000944:Antigens, Differentiation, B-Lymphocyte; D002352:Carrier Proteins; C434484:GOPC protein, human; D000077614:Golgi Matrix Proteins; D000949:Histocompatibility Antigens Class II; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D015514:Oncogene Proteins, Fusion; D011518:Proto-Oncogene Proteins; C493557:SLC34A2 protein, human; D050614:Sodium-Phosphate Cotransporter Proteins, Type IIb; C045084:invariant chain; D011505:Protein-Tyrosine Kinases; C062333:ROS1 protein, human