title: Vitamin D biology revealed through the study of knockout and transgenic mouse models.
abstract: Early studies identifying vitamin D as an antirachitic factor led to studies in vitamin D-deficient models that resulted in a basic understanding of the mechanism of action of vitamin D. Recent studies using genetically modified mice have provided important new insight into the physiological role of vitamin D at target tissues and the functional significance of vitamin D target proteins, as well as the functional significance of proteins involved in the transport and metabolism of vitamin D. Studies using these mice have played an increasingly important role in elucidating the mechanisms involved in the control of calcium homeostasis and have provided evidence for a role of vitamin D in extraskeletal health.
authors: Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ 07103, USA. christak@umdnj.edu
authors: Sylvia
authors: S
authors: Christakos
authors: Tanya
authors: T
authors: Seth
authors: Jennifer
authors: J
authors: Hirsch
authors: Angela
authors: A
authors: Porta
authors: Anargyros
authors: A
authors: Moulas
authors: Puneet
authors: P
authors: Dhawan
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D014807:Vitamin D / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D014807:Vitamin D