title: Different patterns of amygdala priming differentially affect dentate gyrus plasticity and corticosterone, but not CA1 plasticity.
abstract: Stress-induced activation of the amygdala is involved in the modulation of memory processes in the hippocampus. However, stress effects on amygdala and memory remain complex. The activation of the basolateral amygdala (BLA) was found to modulate plasticity in other brain areas, including the hippocampus. We previously demonstrated a differential effect of BLA priming on long-term potentiation (LTP) in the CA1 and the dentate gyrus (DG). While BLA priming suppressed LTP in CA1, it was found to enhance it in the DG. However, since the amygdala itself is amenable to experience-induced plasticity it is thus conceivable that when activity within the amygdala is modified this will have impact on the way the amygdala modulates activity and plasticity in other brain areas. In the current study, we examined the effects of different patterns of BLA activation on the modulation of LTP in the DG and CA1, as well as on serum corticosterone (CORT). In CA1, BLA-priming impaired LTP induction as was reported before. In contrast, in the DG, varying BLA stimulation intensity and frequency resulted in differential effects on LTP, ranging from no effect to strong impairment or enhancement. Varying BLA stimulation patterns resulted in also differential alterations in Serum CORT, leading to higher CORT levels being positively correlated with LTP magnitude in DG but not in CA1. The results support the notion of a differential role for the DG in aspects of memory, and add to this view the possibility that DG-associated aspects of memory will be enhanced under more emotional or stressful conditions. It is interesting to think of BLA patterns of activation and the differential levels of circulating CORT as two arms of the emotional and stress response that attempt to synchronize brain activity to best meet the challenge. It is foreseeable to think of abnormal such synchronization under extreme conditions, which would lead to the development of maladaptive behavior.
authors: CNRS, Unité Mixte de Recherche 5287, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, Université de Bordeaux Talence, France.
authors: Rose-Marie
authors: RM
authors: Vouimba
authors: Gal
authors: G
authors: Richter-Levin
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000502:physiology*; D003345:Corticosterone / Q000097:blood*; D018891:Dentate Gyrus / Q000502:physiology*; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003345:Corticosterone
keywords: BLA; LTP; corticosterone; dentate gyrus; hippocampus; stress
references: Learn Mem. 2007 May 03;14(5):359-67
references: 17522027
references: J Neurophysiol. 1997 Feb;77(2):812-25
references: 9065852
references: Nat Rev Neurosci. 2009 Jun;10(6):459-66
references: 19339973
references: Science. 1991 Sep 20;253(5026):1380-6
references: 1896849
references: Cereb Cortex. 2005 Nov;15(11):1815-21
references: 15716473
references: Neurobiol Learn Mem. 1997 Mar;67(2):176-9
references: 9075247
references: Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1328-33
references: 12538851
references: Hippocampus. 1992 Oct;2(4):421-30
references: 1308198
references: Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14048-53
references: 9391150
references: Eur J Neurosci. 2008 Feb;27(3):715-22
references: 18279323
references: Cereb Cortex. 2007 Jun;17(6):1307-13
references: 16880223
references: Neuron. 1998 May;20(5):937-45
references: 9620698
references: Behav Brain Res. 2010 Dec 31;215(2):180-96
references: 20307583
references: Eur J Neurosci. 1996 Sep;8(9):1833-9
references: 8921274
references: Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5573-8
references: 18391224
references: J Neurosci. 2002 Nov 1;22(21):9502-12
references: 12417674
references: Neurobiol Learn Mem. 2001 Jan;75(1):10-29
references: 11124044
references: Front Neuroendocrinol. 2009 Aug;30(3):358-70
references: 19341764
references: Behav Brain Res. 2012 Jan 1;226(1):56-65
references: 21907247
references: Nature. 1993 Jan 7;361(6407):31-9
references: 8421494
references: Neuroreport. 1999 Sep 9;10(13):2811-5
references: 10511445
references: Prog Brain Res. 2007;163:567-76
references: 17765738
references: Curr Opin Neurobiol. 2002 Apr;12(2):205-10
references: 12015238
references: Eur J Neurosci. 2001 Aug;14(4):719-25
references: 11556896
references: Brain Res. 1996 Nov 4;738(2):229-35
references: 8955517
references: Neurobiol Learn Mem. 1999 Mar;71(2):232-9
references: 10082642
references: Neuroimage. 2002 Sep;17(1):214-22
references: 12482078
references: Eur J Neurosci. 1998 Feb;10(2):457-63
references: 9749708
references: Exp Brain Res. 2003 Sep;152(1):52-9
references: 12879172
references: Brain Res. 2001 Dec 20;922(2):250-60
references: 11743957
references: Behav Neural Biol. 1987 Jul;48(1):138-49
references: 2820370
references: Psychoneuroendocrinology. 2000 Apr;25(3):213-38
references: 10737694
references: Learn Mem. 2004 Mar-Apr;11(2):188-95
references: 15054134
references: J Neurosci. 1999 Dec 1;19(23):10530-5
references: 10575049
references: J Neurosci. 1998 Jan 1;18(1):411-8
references: 9412517
references: J Neurosci. 2004 Sep 15;24(37):8161-9
references: 15371517
references: Science. 2000 Jan 14;287(5451):248-51
references: 10634773
references: Learn Mem. 2008 Feb 22;15(3):112-6
references: 18299437
references: Prog Brain Res. 2008;167:35-51
references: 18037005
references: J Neurosci Res. 2009 Jun;87(8):1823-31
references: 19224582
references: Brain Res. 1999 Dec 18;851(1-2):204-14
references: 10642845
references: Neuron. 2011 May 26;70(4):589-96
references: 21609818
references: Biotechnol J. 2007 May;2(5):596-607
references: 17345578
references: Neuron. 1998 May;20(5):947-57
references: 9620699
references: Nature. 1997 Dec 11;390(6660):604-7
references: 9403688
references: J Comp Neurol. 1999 Jan 11;403(2):229-60
references: 9886046
references: Hippocampus. 2010 Dec;20(12):1332-8
references: 20082290
references: J Neurosci. 2007 Apr 18;27(16):4482-91
references: 17442833
references: Brain Res Bull. 2000 Dec;53(6):783-7
references: 11179843
references: Neuron. 1999 Jun;23(2):229-32
references: 10399930
references: Exp Brain Res. 1984;54(1):1-6
references: 6321219
references: Hippocampus. 2006;16(1):35-42
references: 16200643
references: Neurobiol Learn Mem. 2008 Sep;90(2):395-403
references: 18572424
references: Brain Res. 1996 Jun 3;723(1-2):162-8
references: 8813394
references: J Neurosci. 2005 Feb 9;25(6):1532-9
references: 15703407
references: Hippocampus. 1993 Apr;3(2):183-92
references: 8353605
references: J Neurosci. 1996 Aug 1;16(15):4787-98
references: 8764665
references: Stress. 2006 Mar;9(1):29-40
references: 16753931
references: Eur J Neurosci. 2002 Feb;15(3):553-60
references: 11876783
references: Jpn J Pharmacol. 2001 May;86(1):18-22
references: 11430468
references: Science. 1954 Dec 3;120(3127):949-50
references: 13216196
references: Behav Neurosci. 1996 Apr;110(2):401-12
references: 8731066
references: Neuroscientist. 2004 Feb;10(1):31-9
references: 14987446
references: Ann N Y Acad Sci. 2003 Apr;985:78-91
references: 12724150
references: Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3204-8
references: 9501241
references: Nonlinearity Biol Toxicol Med. 2005 Jan;3(1):9-21
references: 19330154
references: Brain Res. 1998 Apr 13;789(2):245-55
references: 9573376
references: Eur J Neurosci. 2004 Apr;19(7):1887-94
references: 15078562
references: Brain Res Bull. 1998;45(4):389-93
references: 9527013
references: Neuron. 1996 Nov;17(5):875-87
references: 8938120
references: J Neurosci. 1999 Jul 15;19(14):RC18
references: 10407060
references: Ann N Y Acad Sci. 2000 Jun;911:369-91
references: 10911886
references: Behav Neural Biol. 1993 Jul;60(1):84-7
references: 8105777
references: Hippocampus. 2001;11(6):626-36
references: 11811656
references: Neuropharmacology. 2007 Jan;52(1):244-52
references: 16890964
references: Hippocampus. 2010 Jan;20(1):196-207
references: 19360856
references: Nature. 1997 Dec 11;390(6660):607-11
references: 9403689
references: Ann N Y Acad Sci. 1994 Nov 30;746:134-42; discussion 142-4, 178-9
references: 7825871
references: Neuroscience. 1995 Dec;69(4):1087-93
references: 8848097
references: Neuroscience. 2002;115(4):1119-26
references: 12453484
references: Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8477-81
references: 8078906
references: Learn Mem. 2005 Mar-Apr;12(2):96-102
references: 15805308
references: J Neurosci. 2001 Jul 15;21(14):5222-8
references: 11438597