title: [Specific features of the anticonvulsant effect of memantine in mice intoxicated with a model organic phosphate].
abstract: The effect of memantine administration has been studied on the model of mice poisoning with an anticholinesterase compound. It is established that the memantine action is due to its influence on the cholinesterase activity in the brain, blood plasma, and erythrocytes in addition to its NMDA-blocking action. Memantine promotes oxime-induced erythrocyte enzyme reactivation on the model of mice poisoning with anticholinesterase compound (0.8 LD50).
authors: M A
authors: MA
authors: Iudin
authors: S V
authors: SV
authors: Chepur
authors: V N
authors: VN
authors: Bykov
authors: A F
authors: AF
authors: Kurpiakova
authors: S N
authors: SN
authors: Subbotina
authors: A S
authors: AS
authors: Nikiforov
authors: I M
authors: IM
authors: Ivanov
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000506:poisoning; D002801:Cholinesterase Reactivators / Q000378:metabolism / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D007531:Isoflurophate / Q000506:poisoning; D007928:Lethal Dose 50; D008297:Male; D008559:Memantine / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors / Q000378:metabolism; D062025:Organophosphate Poisoning / Q000097:blood / Q000188:drug therapy*; D010091:Oximes / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D010091:Oximes; D007531:Isoflurophate; D016202:N-Methylaspartate; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D008559:Memantine