title: Metabolic syndrome and hemoglobin levels in elderly adults: the Invecchiare in Chianti Study.
abstract: OBJECTIVE
  To assess the association between metabolic syndrome (MetS) and hemoglobin levels in older adults.
  
  
  METHODS
  The Invecchiare in Chianti (InCHIANTI) Study, a cohort study with a 6-year follow-up.
  
  
  METHODS
  Tuscany, Italy.
  
  
  METHODS
  Adults aged 65 and older (N = 1,036).
  
  
  METHODS
  MetS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III criteria. The adjusted association between baseline hemoglobin and MetS was assessed using multivariable linear regression with hemoglobin as a continuous variable and using logistic regression with median hemoglobin level as the reference. Logistic regression was also performed with any incident decline in hemoglobin levels as the dependent variable.
  
  
  RESULTS
  MetS was diagnosed in 263 (25%) participants. At baseline, MetS was associated with higher hemoglobin levels (B = 0.18, 95% confidence interval (CI) = 0.03-0.33, P = .02) and with hemoglobin levels above the median value (odds ratio (OR) = 1.65, 95% CI = 1.17-2.32, P = .004) after adjusting. After 6 years, MetS was associated with lower adjusted probability of lower hemoglobin levels (OR = 0.34, 95% CI = 0.15-0.79, P = .012) but only in the oldest tertile of participants.
  
  
  CONCLUSIONS
  MetS is associated with higher hemoglobin levels in older subjects and with lower probability of hemoglobin loss over 6 years in those in the oldest age group.
authors: Geriatrics Section, Campus Bio-Medico University, Rome, Italy.
authors: Alice
authors: A
authors: Laudisio
authors: Geriatric Rehabilitation Unit, Azienda Sanitaria di Firenze, Florence, Italy.
authors: Stefania
authors: S
authors: Bandinelli
authors: UOS Accesso e Presa in Carico Assistenziale, Azienda Sanitaria Locale Roma E, Rome, Italy.
authors: Antonella
authors: A
authors: Gemma
authors: Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland.
authors: Luigi
authors: L
authors: Ferrucci
authors: Geriatrics Section, Campus Bio-Medico University, Rome, Italy.
authors: Raffaele
authors: R
authors: Antonelli Incalzi
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D016330:Frail Elderly; D015577:Geriatric Assessment / Q000379:methods*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology*; D016017:Odds Ratio; D015995:Prevalence; D011446:Prospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012737:Sex Factors; D015996:Survival Rate / Q000639:trends; D013997:Time Factors
chemical_list: D006454:Hemoglobins
references: Int J Epidemiol. 1996 Aug;25(4):775-82
references: 8921456
references: J Gerontol A Biol Sci Med Sci. 2006 May;61(5):474-9
references: 16720744
references: Eur J Heart Fail. 2010 Jun;12(6):566-73
references: 20354030
references: Public Health Nutr. 2002 Dec;5(6B):1329-45
references: 12639236
references: Biol Psychiatry. 2008 Nov 15;64(10):896-900
references: 18597739
references: Anesth Analg. 2011 Jan;112(1):23-9
references: 21127285
references: J Gerontol A Biol Sci Med Sci. 2005 Sep;60(9):1168-72
references: 16183958
references: Clin Sci (Lond). 2008 Feb;114(3):183-93
references: 18184112
references: J Gerontol A Biol Sci Med Sci. 2009 Mar;64(3):403-10
references: 19196903
references: Circ Heart Fail. 2009 Nov;2(6):563-71
references: 19919981
references: Diabetes Care. 2004 Oct;27(10):2422-8
references: 15451911
references: Lancet. 2005 Apr 16-22;365(9468):1415-28
references: 15836891
references: J Am Geriatr Soc. 2005 Dec;53(12):2106-11
references: 16398894
references: Arch Intern Med. 2000 Sep 25;160(17):2641-4
references: 10999978
references: J Am Geriatr Soc. 2009 Sep;57(9):1604-11
references: 19682133
references: Metabolism. 2011 Oct;60(10):1416-24
references: 21489582
references: J Am Geriatr Soc. 2000 Dec;48(12):1618-25
references: 11129752
references: Clin Nutr. 2008 Oct;27(5):747-54
references: 18715681
references: J Am Coll Cardiol. 2004 Apr 21;43(8):1439-44
references: 15093881
references: Clin Endocrinol (Oxf). 2007 May;66(5):666-71
references: 17381490
references: Int J Epidemiol. 1997;26 Suppl 1:S152-60
references: 9126543
references: J Am Geriatr Soc. 2004 Nov;52(11):1811-6
references: 15507056
references: Medicine (Baltimore). 2009 Mar;88(2):107-114
references: 19282701
references: J Am Geriatr Soc. 2004 May;52(5):719-24
references: 15086651
references: Circulation. 2004 Jan 27;109(3):433-8
references: 14744958
references: J Gerontol A Biol Sci Med Sci. 2005 Jun;60(6):729-35
references: 15983175
references: J Gerontol A Biol Sci Med Sci. 2012 Jan;67(1):100-6
references: 21896502
references: Eur J Nutr. 2013 Feb;52(1):307-16
references: 22406906