title: Acute splenic sequestration in a pregnant woman with homozygous sickle-cell anemia.
abstract: BACKGROUND
  Homozygous (SS) sickle-cell anemia complicated by acute splenic sequestration in adults is a rare event, and it has never been reported during pregnancy.
  
  
  METHODS
  A 25-year-old woman with homozygous (SS) sickle-cell disease was hospitalized at 32 weeks' of gestation presenting weakness, abdominal pain, fever and hemoglobin of 2.4 g/dl. Abnormal fetal heart rate was detected by means of cardiotocography, and 5 units of packed red cells were transfused. Cesarean was performed at 37 weeks. Both mother and baby were discharged in a good general condition.
  
  
  CONCLUSIONS
  This case report demonstrates the importance of immediate blood transfusion for treatment of fetal distress in cases of splenic sequestration during pregnancy. This treatment is essential for avoiding maternal and fetal complications.
authors: Department of Obstetrics and Gynecology, Faculdade de Medicina da Universidade de São Paulo FMUSP, São Paulo, Brazil. maiacarol@yahoo.com.br
authors: Carolina Bastos
authors: CB
authors: Maia
authors: Roseli Mieko Yamamoto
authors: RM
authors: Nomura
authors: Ana Maria Kondo
authors: AM
authors: Igai
authors: Guilherme Hencklain
authors: GH
authors: Fonseca
authors: Sandra Menosi
authors: SM
authors: Gualandro
authors: Marcelo
authors: M
authors: Zugaib
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000235:genetics; D001805:Blood Transfusion, Intrauterine / Q000379:methods*; D005260:Female; D005316:Fetal Distress / Q000628:therapy*; D006720:Homozygote; D006801:Humans; D011247:Pregnancy; D013158:Splenic Diseases / Q000209:etiology*
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