title: Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs.
abstract: Mass spectrometry (MS) has emerged as an important tool for studying anticancer metallodrugs in complex biological samples and for characterising their interactions with biomolecules and potential targets on a molecular level. The exact modes-of-action of these coordination compounds and especially of next generation drug candidates have not been fully elucidated. Due to the fact that DNA is considered a crucial target for platinum chemotherapeutics, metallodrug-DNA binding studies dominated the field for a long time. However, more recently, alternative targets were considered, including enzymes and proteins that may play a role in the overall pharmacological and toxicological profile of metallodrugs. This review focuses on MS-based techniques for studying anticancer metallodrugs in vivo, in vitro and in situ to delineate their modes-of-action.
authors: School of Chemical Sciences, The University of Auckland, 1142 Auckland, New Zealand. c.hartinger@auckland.ac.nz
authors: Christian G
authors: CG
authors: Hartinger
authors: Michael
authors: M
authors: Groessl
authors: Samuel M
authors: SM
authors: Meier
authors: Angela
authors: A
authors: Casini
authors: Paul J
authors: PJ
authors: Dyson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D018736:DNA Adducts / Q000737:chemistry; D006801:Humans; D013058:Mass Spectrometry; D008670:Metals / Q000737:chemistry*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D018736:DNA Adducts; D008670:Metals; D011506:Proteins; D004247:DNA