title: Tea toxicity and cholinesterase inhibition of Huilliche herbal medicine.
abstract: Eleven species of Huilliche medicinal plants used traditionally against infections and for wound healing were tested for their cholinesterase inhibition activity. Two different teas (a 5-7 min infusion and a 1 h decoction, both in water) were tested for their toxicity against Artemia salina. The results from the present study clearly show that teas boiled for 1 h is much more toxic than teas infused for 5-7 min. These results support the different traditional use of the two teas, where the 1h tea is for external use only. Additionally, significant inhibition of cholinesterase has been observed for MeOH extracts of Acaena argentea, Amomyrtas meli and Pseudopanax laetevirens, with that of A. argentea being the most potent. All findings call for further investigations.
authors: Department of Medicinal Chemistry, University of Copenhagen, Copenhagen, Denmark. aad@farma.ku.dk
authors: Anne
authors: A
authors: Adsersen
authors: Alfonso
authors: A
authors: Guzman
authors: Per
authors: P
authors: Mølgaard
authors: Henrik Toft
authors: HT
authors: Simonsen
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D001156:Artemia; D002677:Chile; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004593:Electrophorus; D019684:Magnoliopsida; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000009:adverse effects* / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal / Q000009:adverse effects; D014945:Wound Healing
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D000110:Acetylcholinesterase