title: Application of hot melt extrusion for poorly water-soluble drugs: limitations, advances and future prospects.
abstract: Hot melt extrusion (HME) is a powerful technology to enhance the solubility and bioavailability of poorly water-soluble drugs by producing amorphous solid dispersions. Although the number of articles and patents about HME increased dramatically in the past twenty years, there are very few commercial products by far. The three main obstacles limiting the commercial application of HME are summarized as thermal degradation of heat-sensitive drugs at high process temperature, recrystallization of amorphous drugs during storage and dissolving process, and difficulty to obtain products with reproducible physicochemical properties. Many efforts have been taken in recent years to understand the basic mechanism underlying these obstacles and then to overcome them. This article reviewed and summarized the limitations, recent advances, and future prospects of HME.
authors: Ming
authors: M
authors: Lu
authors: Zhefei
authors: Z
authors: Guo
authors: Yongcheng
authors: Y
authors: Li
authors: Huishi
authors: H
authors: Pang
authors: Ling
authors: L
authors: Lin
authors: Xu
authors: X
authors: Liu
authors: Xin
authors: X
authors: Pan
authors: School of Pharmaceutical Sciences, Sun Yat-Sen University Guangzhou, 510006, Guangdong, People's Republic of China. cbwu2000@yahoo.com.
authors: Chuanbin
authors: C
authors: Wu
mesh_terms: D001682:Biological Availability; D004337:Drug Carriers / Q000737:chemistry; D004355:Drug Stability; D004356:Drug Storage; D004867:Equipment Design; D006358:Hot Temperature; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000592:standards; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011108:Polymers; D014867:Water