title: Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo.
abstract: Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale micelles. The CRGDK peptide triggered specific binding to neuropilin-1, leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation and penetration in the tumors in vivo.
authors: Chinese Academy of Sciences (CAS) Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11, First North Road, Zhongguancun, Beijing, China 100190.
authors: Tuo
authors: T
authors: Wei
authors: Juan
authors: J
authors: Liu
authors: Huili
authors: H
authors: Ma
authors: Qiang
authors: Q
authors: Cheng
authors: Yuanyu
authors: Y
authors: Huang
authors: Jing
authors: J
authors: Zhao
authors: Shuaidong
authors: S
authors: Huo
authors: Xiangdong
authors: X
authors: Xue
authors: Zicai
authors: Z
authors: Liang
authors: Xing-Jie
authors: XJ
authors: Liang
mesh_terms: D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D066298:In Vitro Techniques; D008823:Micelles; D049329:Nanostructures; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D008823:Micelles