title: [Acceleration of Jingui Shenqi Pill on the testis telomerase activity in mice of Shen-yang deficiency].
abstract: OBJECTIVE
  To explore the effects of Jingui Shenqi Pill (JSP) on the testis telomerase activity in mice of Shen-yang deficiency syndrome (SYDS).
  
  
  METHODS
  The SYDS model was prepared in 30 mice by over-fatigue and sexual overstrain. They were randomly divided into the model group and the JSP group, 15 in each group. Another 15 normal male mice were selected as the normal group. Mice in the normal group were fed routinely, with distilled water administered intragastrically at the daily dose of 0.1 mL/10 g. Mice in the model group were also administered intragastrically with distilled water at the daily dose of 0.1 mL/10 g while modeling establishment. Mice in the treatment group were administered intragastrically with JSP suspension at 0.1 mL/10 g (the concentration was 0.241 g/mL). The intervention lasted for 4 weeks. Four weeks later, the testis telomerase activity was detected in the three groups by ELISA.
  
  
  RESULTS
  The SYDS model was replicated successfully by over-fatigue and sexual overstrain. JSP could improve the signs of mice of SYDS. Compared with the normal group, the activity of testis telomerase decreased in the model group (P < 0.01). Compared with the model group, the testis telomerase activity markedly increased in the treatment group (P < 0.01).
  
  
  CONCLUSIONS
  The testis telomerase activity in mice of SYDS caused by over-fatigue and sexual overstrain obviously decreased, when compared with that in mice of the normal group. JSP could recover its activity.
authors: Human Resource De partment, Shandong Provincial Qianfoshan Hospital, Jinan (250014), China. xucuiping775@sohu.com
authors: Cui-Ping
authors: CP
authors: Xu
authors: Qing-Jun
authors: QJ
authors: Zhu
authors: Jie
authors: J
authors: Song
authors: Zhen
authors: Z
authors: Li
authors: Dan
authors: D
authors: Zhang
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D019098:Telomerase / Q000378:metabolism*; D013737:Testis / Q000187:drug effects / Q000201:enzymology*; D016711:Yang Deficiency / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D004365:Drugs, Chinese Herbal; C510025:jingui shenqi; D019098:Telomerase