title: Correlation between morphological and functional liver volume in each sector using integrated SPECT/CT imaging by computed tomography and technetium-99m galactosyl serum albumin scintigraphy in patients with various diseases who had undergone hepatectomy.
abstract: OBJECTIVE
  The aim of the study was to accurately examine the functional volume (RI-vol) of the hepatic segments on single photon emission computed tomography/computed tomography (CT) fusion imaging by technetium-99m galactosyl human serum albumin scintigraphy and compare it with the RI-vol and morphological volume obtained on computed tomography (CT-vol).
  
  
  METHODS
  In 60 patients with various liver background statuses who had undergone hepatectomy, the RI-vol and CT-vol were examined in each sector using imaging analysis. The values from a control group (n=91) were used as reference data.
  
  
  RESULTS
  The mean RI-vol and CT-vol of the right liver were 64 ± 10 and 63 ± 6%, respectively, whereas the values for the left liver were 36 ± 10 and 37 ± 6%, respectively. Compared with the control group, the ratios in each hemiliver were similar. The mean RI-vol and CT-vol for each sector were also similar, and significant positive correlations were identified between the two volumes (P<0.01). In four patients with hepatic tumors involving the main hepatic vessels or the bile duct and in 10 patients who had undergone portal vein embolization, the actual RI-vol in the injured sector was significantly decreased compared with CT-vol (P<0.05). There were marked changes in functional volume in segment 6+7 and segment 2+3 after portal vein embolization (P<0.05).
  
  
  CONCLUSIONS
  Volumetric measurement using single photon emission computed tomography/CT imaging with technetium-99m galactosyl human serum albumin scintigraphy is useful for evaluating the functional volume in separated livers and offers a good reflection of the background liver status.
authors: Department of Surgery, Division of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Japan. a-nanasm@nagasaki-u.ac.jp
authors: Atsushi
authors: A
authors: Nanashima
authors: Takafumi
authors: T
authors: Abo
authors: Syuuichi
authors: S
authors: Tobinaga
authors: Goushi
authors: G
authors: Murakami
authors: Yasuo
authors: Y
authors: Kido
authors: Tooru
authors: T
authors: Fukuda
authors: Tomoshi
authors: T
authors: Tsuchiya
authors: Hirofumi
authors: H
authors: Matsumoto
authors: Takeshi
authors: T
authors: Nagayasu
authors: Takashi
authors: T
authors: Kudo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004621:Embolization, Therapeutic; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D008107:Liver Diseases / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009929:Organ Size; D011169:Portal Vein / Q000503:physiopathology; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; D016284:Technetium Tc 99m Pentetate