title: Evaluation of bone alterations in the jaws of HIV-infected menopausal women.
abstract: The advent of highly active antiretroviral therapy (HAART) has caused a reduction in mortality, thus contributing to an increase in the number of women with HIVࢧAIDS who reach the climacteric period, experience decline in ovarian function, and develop complications of viral infection and HAART, which can accelerate bone loss. The aim of this study was to detect possible alterations in the jaws of HIV-infected women by panoramic radiography. The study comprised a total of 120 women above 40 years of age who were divided into the following two groups: women who are HIV positive (Group I) and women with no known HIV infection (Group II). Measurement of the following three radiomorphometric indexes was performed by panoramic radiography: Mental Index (MI), Panoramic Mandibular Index (PMI) and Antegonial Depth (AD). A total of 70% of women in the control group and 50% of women in the HIV group were in the postmenopausal period, and the average values of both MI (p = 0.0054) and AD (p < 0.0001) for this period were lower in the HIV group than in the control group. For patients who were in the premenopausal period, the average AD was lower in the HIV group than in the control group (p = 0.0003). Despite the difference in the average age between groups, greater bone resorption in the mandible was found in the group of HIV-positive women.
authors: Center for Study and Care of Special Patients, Dental School, Univ Paulista, São Paulo, SP, Brazil. bruvc@globo.com
authors: Bruno Vieira
authors: BV
authors: Caputo
authors: Gabriela Cineze
authors: GC
authors: Traversa-Caputo
authors: Claudio
authors: C
authors: Costa
authors: Elcio Magdalena
authors: EM
authors: Giovani
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D015519:Bone Density / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007568:Jaw / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000139:chemically induced / Q000000981:diagnostic imaging*; D011862:Radiography, Panoramic; D012307:Risk Factors