title: Associations between arterial stiffness and platelet activation in normotensive overweight and obese young adults.
abstract: Obese individuals have elevated platelet activation and arterial stiffness, but the strength and temporality of the relationship between these factors remain unclear. We aimed to determine the effect of increased arterial stiffness on circulating platelet activity in overweight/obese young adults. This analysis included 92 participants (mean age 40 years, 60 women) in the Slow Adverse Vascular Effects of excess weight (SAVE) trial, a clinical trial examining the effects of a lifestyle intervention with or without sodium restriction on vascular health in normotensive overweight/obese young adults. Carotid-femoral (cf), brachial-ankle (ba) and femoral-ankle (fa) pulse wave velocity (PWV) served as measures of arterial stiffness and were measured at baseline and 6, 12 and 24 months follow-up. Platelet activity was measured as plasma β-thromboglobulin (β-TG) at 24 months. Higher plasma β-TG was correlated with greater exposure to elevated cfPWV (p = 0.02) and baPWV (p = 0.04) during the preceding two years. After adjustment for serum leptin, greater exposure to elevated baPWV remained significant (p = 0.03) and exposure to elevated cfPWV marginally significant (p = 0.054) in predicting greater plasma β-TG. Greater arterial stiffness, particularly central arterial stiffness, predicts greater platelet activation in overweight/obese individuals. This relationship might partly explain the association between increased arterial stiffness and incident atherothrombotic events.
authors: Department of Epidemiology, Graduate School of Public Health .
authors: Jennifer N
authors: JN
authors: Cooper
authors: Rhobert W
authors: RW
authors: Evans
authors: Maria
authors: M
authors: Mori Brooks
authors: Linda
authors: L
authors: Fried
authors: Chris
authors: C
authors: Holmes
authors: Emma
authors: E
authors: Barinas-Mitchell
authors: Kim
authors: K
authors: Sutton-Tyrrell
mesh_terms: D000328:Adult; D055109:Ankle Brachial Index; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000097:blood*; D015539:Platelet Activation / Q000502:physiology*; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult
chemical_list: D020738:Leptin
references: J Thromb Haemost. 2007 Oct;5(10):2036-42
references: 17883700
references: Am J Kidney Dis. 1996 Jun;27(6):809-18
references: 8651245
references: J Hum Hypertens. 2005 Jul;19(7):527-33
references: 15815694
references: Hypertension. 2008 Jun;51(6):1512-8
references: 18426995
references: Am J Hypertens. 2011 Jan;24(1):70-6
references: 20508622
references: Haemostasis. 1996 Mar-Apr;26(2):98-106
references: 9119289
references: Platelets. 2011;22(6):447-51
references: 21473674
references: Am J Clin Nutr. 2010 Nov;92(5):1172-80
references: 20826631
references: Thromb Haemost. 2009 Aug;102(2):248-57
references: 19652875
references: Thromb Haemost. 2008 Dec;100(6):1123-9
references: 19132239
references: Clin Sci (Lond). 2007 Aug;113(4):157-70
references: 17623012
references: Blood. 1981 Feb;57(2):199-202
references: 6160890
references: J Lab Clin Med. 1985 Feb;105(2):271-6
references: 3882862
references: Clin Exp Hypertens. 2012;34(1):63-70
references: 22007645
references: Blood Press. 2010 Feb;19(1):26-30
references: 19929284
references: J Hum Hypertens. 1997 Sep;11(9):607-9
references: 9364284
references: Hypertension. 2003 Oct;42(4):468-73
references: 12953016
references: Thromb Haemost. 2011 Oct;106(4):683-92
references: 21866298
references: J Appl Stat. 2009 Jun;36(6):611-619
references: 20087408
references: JAMA. 2002 Oct 23-30;288(16):2008-14
references: 12387653
references: Circ Res. 2005 Apr 1;96(6):612-6
references: 15802619
references: Int J Clin Pract. 2005 Aug;59(8):981-2
references: 16033624
references: J Hypertens. 2007 Feb;25(2):265-72
references: 17211229
references: Atherosclerosis. 2011 Oct;218(2):263-71
references: 21621778
references: Obes Rev. 2012 Jan;13(1):27-42
references: 21917110
references: JAMA. 2003 Apr 9;289(14):1781-2
references: 12684355
references: Blood. 1996 Nov 1;88(9):3456-64
references: 8896411
references: J Am Soc Nephrol. 2006 Aug;17(8):2245-52
references: 16837632
references: Circulation. 2001 Jul 10;104(2):140-4
references: 11447076
references: Atherosclerosis. 2004 Mar;173(1):13-8
references: 15177119
references: J Am Coll Cardiol. 2010 Mar 30;55(13):1318-27
references: 20338492
references: J Am Coll Cardiol. 2003 Dec 17;42(12):2096-8
references: 14680733
references: Nutr Metab Cardiovasc Dis. 2008 Mar;18(3):227-32
references: 17400434
references: Eur Heart J. 2010 Aug;31(15):1865-71
references: 20197424