title: Regulatory T cell-derived IL-10 ameliorates crescentic GN.
abstract: Regulatory T cells (Tregs) exert their immunosuppressive activity through several immunoregulatory mechanisms, including the production of anti-inflammatory cytokines such as IL-10. Although several studies suggest a role for Tregs in modulating crescentic GN, the underlying mechanisms are not well understood. Here, using IL-10 reporter mice, we detected IL-10-producing Foxp3(+) T cells in the kidney, blood, and secondary lymphoid tissue in a mouse model of crescentic GN. Specific inactivation of Il10 in Foxp3(+) Tregs eliminated the ability of these cells to suppress renal and systemic production of IFNγ and IL-17; these IL-10-deficient Tregs lost their capacity to attenuate renal tissue injury. These data highlight the suppressive functions of Tregs in crescentic GN and suggest the importance of Treg-derived IL-10 in ameliorating disease severity and in modulating both the Th1 and most notably Th17 immune response.
authors: Institut für Experimentelle Immunologie und Hepatologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
authors: Annett
authors: A
authors: Ostmann
authors: Hans-Joachim
authors: HJ
authors: Paust
authors: Ulf
authors: U
authors: Panzer
authors: Claudia
authors: C
authors: Wegscheid
authors: Sonja
authors: S
authors: Kapffer
authors: Samuel
authors: S
authors: Huber
authors: Richard A
authors: RA
authors: Flavell
authors: Annette
authors: A
authors: Erhardt
authors: Gisa
authors: G
authors: Tiegs
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D001798:Blood Proteins / Q000276:immunology / Q000633:toxicity; D003713:Dendritic Cells / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D051858:Forkhead Transcription Factors / Q000235:genetics; D005921:Glomerulonephritis / Q000139:chemically induced / Q000276:immunology*; D016753:Interleukin-10 / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D007668:Kidney / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012333:RNA, Messenger / Q000378:metabolism; D012720:Severity of Illness Index; D012756:Sheep; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000473:pathology*; D018417:Th1 Cells / Q000276:immunology / Q000473:pathology; D058504:Th17 Cells / Q000276:immunology / Q000473:pathology
chemical_list: D001798:Blood Proteins; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; C556062:IL10 protein, mouse; D012333:RNA, Messenger; D016753:Interleukin-10
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