title: Would the real human embryonic stem cell please stand up?
abstract: Embryonic stem cells (ESCs) are now classified into two types of pluripotency: "naïve" and "primed" based upon their differing characteristics. Conventional human ESCs have much more in common with mouse epiblast stem cells and are now deemed to be primed. Naïve human ESCs that resemble mouse ESCs have recently been generated from their primed counterpart by cellular reprogramming. Isolation of naïve hESCs from human embryos has proven to be difficult. Is the inability to capture naïve hESCs the result of suboptimal derivation conditions or because they are so transient they cannot be "captured" in vitro? Prevailing evidence surrounding this issue are inconclusive and require additional human embryo research. However, negative public opinion regarding human embryo research, may make this an uphill battle. The solution may come from cellular reprogramming.
authors: Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada.
authors: Ben
authors: B
authors: Zhang
authors: Roman
authors: R
authors: Krawetz
authors: Derrick E
authors: DE
authors: Rancourt
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004195:Disease Models, Animal; D053595:Embryonic Stem Cells / Q000166:cytology*; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D015870:Gene Expression; D005855:Germ Layers / Q000166:cytology; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D051379:Mice; D039904:Pluripotent Stem Cells / Q000166:cytology; D015398:Signal Transduction; D049951:X Chromosome Inactivation
chemical_list: D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3