title: [Dyslipidemia].
abstract: Obesity-associated dyslipidemia is characterized as hyper-triglyceridemia and hypo-high-density lipoproteinemia. Visceral fat accumulation results in the dysregulation of various adipocytokines as well as the elevation of portal free fatty acid and glycerol levels. The latter cause hepatic overproduction of very-low-density lipoprotein, and the adipocytokine dysregulations impair the transfer of cholesterol from extra-hepatic tissues to the liver. In addition, obesity disease associates with the elevated atherogenic remnant lipoprotein as a result of increased lipid absorption and decreased lipoprotein hydrolysis due to insulin resistance. It is important to further elucidate the regulatory mechanisms of adipocytokines on lipid metabolism for the prevention of atherosclerosis.
authors: Department of Biomedical Informatics, Graduate School of Medicine, Osaka University.
authors: Shinji
authors: S
authors: Kihara
mesh_terms: D054392:Adipokines / Q000378:metabolism; D050171:Dyslipidemias / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D050356:Lipid Metabolism; D008079:Lipoproteins, VLDL / Q000378:metabolism; D009765:Obesity / Q000378:metabolism
chemical_list: D054392:Adipokines; D008079:Lipoproteins, VLDL