title: Telangiectatic osteosarcoma.
abstract: OBJECTIVE
  To review records of 8 patients with telangiectatic osteosarcoma (TOS) and determine whether pathologic fractures correlate with recurrence and survival.
  
  
  METHODS
  Records of 4 men and 4 women aged 17 to 44 (mean, 28) years treated for TOS were reviewed. RESULTS; Of the 8 patients, 4 developed a pathologic fracture and 4 did not. In each group, 2 patients underwent limb salvage surgery and 2 underwent amputation. All patients received neoadjuvant and adjuvant chemotherapy with a combination of at least 2 of the following drugs: doxorubicin, methotrexate, cisplatin, and vincristin. After a mean follow-up of 5.6 (range, 2-16) years, all 4 patients with a pathologic fracture and 2 of the 4 patients without a pathologic fracture were still alive and disease-free. For the remaining patients, one died after 31 months from progression of a lung metastasis, and the other was alive with the disease and had had 2 recurrences, a lung metastasis, and an infection with Klebsiella oxytoca that eventually led to an amputation.
  
  
  CONCLUSIONS
  The presence of a pathologic fracture in patients with TOS was not associated with worse outcome in terms of recurrence and survival.
authors: Department of Oncologic Orthopaedic Surgery, Hospital de Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain. jcolomina@gss.scs.es
authors: Jordi
authors: J
authors: Colomina
authors: Ana
authors: A
authors: Peiro
authors: Laura
authors: L
authors: Trullols
authors: Isidre
authors: I
authors: Garcia
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000098:blood supply / Q000150:complications* / Q000401:mortality / Q000628:therapy; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology* / Q000401:mortality; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D012516:Osteosarcoma / Q000098:blood supply / Q000150:complications* / Q000401:mortality / Q000628:therapy; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult
keywords: disease-free survival; fractures, spontaneous; neoplasm metastasis; neoplasm recurrence, local; osteosarcoma; prognosis