title: [Molecular genetic bases of adaptation processes and approaches to their analysis].
abstract: Great interest in studying the molecular genetic bases of the adaptation processes is explained by their importance in understanding evolutionary changes, in the development ofintraspecific and interspecific genetic diversity, and in the creation of approaches and programs for maintaining and restoring the population. The article examines the sources and conditions for generating adaptive genetic variability and contribution of neutral and adaptive genetic variability to the population structure of the species; methods for identifying the adaptive genetic variability on the genome level are also described. Considerable attention is paid to the potential of new technologies of genome analysis, including next-generation sequencing and some accompanying methods. In conclusion, the important role of the joint use of genomics and proteomics approaches in understanding the molecular genetic bases of adaptation is emphasized.
authors: Vavilov Institute of General Genetics, RAS, Moscow, Russia
authors: E A
authors: EA
authors: Salmenkova
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D019143:Evolution, Molecular; D014644:Genetic Variation; D023281:Genomics / Q000379:methods; D011153:Population / Q000235:genetics