title: Trabecular bone deterioration at the greater trochanter of mice with unilateral obstructive nephropathy.
abstract: Our previous study showed the early molecular responses of bone in response to obstructive nephropathy in a unilateral ureteral obstruction (UUO) mouse model. Here, we addressed the changes in trabecular bone properties at greater trochanter, the proximal and the distal metaphysis of femur in UUO mice. The male mice were subjected to UUO (n=10) or sham operation (n=10). All mice were killed on day 7 after the surgical operation. The micro-computed tomography (micro-CT) analysis for different femoral trabecular bone sites demonstrated pathological alterations of trabecular bone mass and micro-networks at greater trochanter as shown by decreases in bone mineral density/bone volume (P<0.05) and trabecular number (P<0.05) and increases in trabecular separation (P<0.01) and bone surface/bone volume (P<0.05) in UUO mice. The present study demonstrates that UUO-induced unilateral obstructive nephropathy has markedly detrimental effects on the trabecular trochanter of the femur.
authors: Center for Systems Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai 200093, China.
authors: Sa-Sa
authors: SS
authors: Gu
authors: Yan
authors: Y
authors: Zhang
authors: Xi
authors: X
authors: Chen
authors: Teng-Yue
authors: TY
authors: Diao
authors: Yoseph
authors: Y
authors: Gebru
authors: Man-Sau
authors: MS
authors: Wong
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000000981:diagnostic imaging* / Q000209:etiology; D004195:Disease Models, Animal; D005269:Femur / Q000000981:diagnostic imaging*; D021621:Imaging, Three-Dimensional; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D014517:Ureteral Obstruction / Q000150:complications*; D055114:X-Ray Microtomography
references: Nephrology (Carlton). 2011 Aug;16(6):588-94
references: 21649792
references: Comput Methods Biomech Biomed Engin. 1997;1(1):15-23
references: 11264794
references: Br J Nutr. 2010 Oct;104(7):965-71
references: 20487580
references: Nefrologia. 2011;31(5):514-9
references: 21959717
references: J Bone Miner Res. 2011 Jun;26(6):1368-76
references: 21611975
references: Nephrology (Carlton). 2012 Nov;17(8):767-73
references: 22943310
references: J Bone Miner Res. 2010 Jul;25(7):1468-86
references: 20533309
references: Int Orthop. 2000;24(3):179-80
references: 10990395
references: Nephrology (Carlton). 2011 Nov;16(8):710-4
references: 22029643
references: J Am Soc Nephrol. 2010 Jun;21(6):966-73
references: 20378820