title: Immunity to bacterial infection in the chicken.
abstract: Bacterial infections remain important to the poultry industry both in terms of animal and public health, the latter due to the importance of poultry as a source of foodborne bacterial zoonoses such as Salmonella and Campylobacter. As such, much focus of research to the immune response to bacterial infection has been to Salmonella. In this review we will focus on how research on avian salmonellosis has developed our understanding of immunity to bacteria in the chicken from understanding the role of TLRs in recognition of bacterial pathogens, through the role of heterophils, macrophages and γδ lymphocytes in innate immunity and activation of adaptive responses to the role of cellular and humoral immunity in immune clearance and protection. What is known of the immune response to other bacterial infections and in particular infections that have emerged recently as major problems in poultry production including Campylobacter jejuni, Avian Pathogenic Escherichia coli, Ornithobacterium rhinotracheale and Clostridium perfringens are discussed.
authors: Department of Infection Biology, Institute of Infection and Global Health, School of Veterinary Science, University of Liverpool, United Kingdom. paul.wigley@liv.ac.uk
authors: Paul
authors: P
authors: Wigley
mesh_terms: D000818:Animals; D016123:Campylobacter jejuni / Q000276:immunology; D002645:Chickens / Q000276:immunology* / Q000382:microbiology; D003016:Clostridium perfringens / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D016905:Gram-Negative Bacterial Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D016908:Gram-Positive Bacterial Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D056724:Immunity, Humoral; D007113:Immunity, Innate; D008214:Lymphocytes / Q000276:immunology / Q000382:microbiology; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D009504:Neutrophils / Q000276:immunology / Q000382:microbiology; D045246:Ornithobacterium / Q000276:immunology; D011201:Poultry Diseases / Q000276:immunology* / Q000382:microbiology; D051193:Toll-Like Receptors / Q000235:genetics / Q000276:immunology
chemical_list: D051193:Toll-Like Receptors
keywords: Campylobacter; Cytokines; Defensins; Lymphocyte; Macrophage; Salmonella; Toll-like receptors