title: Microbial biosensors: engineered microorganisms as the sensing machinery.
abstract: Whole-cell biosensors are a good alternative to enzyme-based biosensors since they offer the benefits of low cost and improved stability. In recent years, live cells have been employed as biosensors for a wide range of targets. In this review, we will focus on the use of microorganisms that are genetically modified with the desirable outputs in order to improve the biosensor performance. Different methodologies based on genetic/protein engineering and synthetic biology to construct microorganisms with the required signal outputs, sensitivity, and selectivity will be discussed.
authors: Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA. miso@udel.edu
authors: Miso
authors: M
authors: Park
authors: Shen-Long
authors: SL
authors: Tsai
authors: Wilfred
authors: W
authors: Chen
mesh_terms: D001419:Bacteria / Q000235:genetics*; D015374:Biosensing Techniques / Q000379:methods*; D002477:Cells / Q000378:metabolism; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans
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