title: A retrospective audit of 200 cases of CNS tumours and their surgical management in a tertiary care centre.
abstract: OBJECTIVE
  To study the nature of the tumours managed in the Irish population.
  
  
  METHODS
  This audit research was completed via a retrospective medical review on 200 patients with CNS tumours managed in a tertiary care centre between 2008 and 2009.
  
  
  RESULTS
  The mean age was 53 years. The male:female ratio was 2:1. The majority were glioblastomas and astrocytomas. Grade IV tumours were predominant (65.5 %). Headaches (37 %), motor weakness (32 %) and seizures (25.5 %) were the highest presentations. The commonest sites affected were the left parietal and left temporal lobes. There were 17.5 % operative morbidities with motor weakness (22.9 %), seizure (14.3 %) and thrombo-embolism (14.3 %) dominating and significant association to surgical radicality (p = 0.041). 3.5 % operative mortalities were reported. 52.5 and 62.5 % of patients received adjuvant chemotherapy and radiotherapy, respectively.
  
  
  CONCLUSIONS
  Patients with CNS tumours typically had multiple presentations. More extensive surgical resection was associated with higher postoperative morbidities (p = 0.041). The 30-day postoperative morbidity (17.5 %) and mortality (3.5 %) were concordant with the currently available literature.
authors: Department of Neurosurgery, Cork University Hospital, Wilton, Cork, Republic of Ireland, faimee.erwan@yahoo.com.
authors: F E
authors: FE
authors: Muhamat Nor
authors: K
authors: K
authors: Chandrasekaran
authors: J C
authors: JC
authors: Marks
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001254:Astrocytoma / Q000150:complications / Q000401:mortality / Q000601:surgery*; D016543:Central Nervous System Neoplasms / Q000150:complications / Q000401:mortality / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000401:mortality / Q000601:surgery*; D006261:Headache / Q000209:etiology; D006801:Humans; D007223:Infant; D007494:Ireland; D008297:Male; D008485:Medical Audit; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000209:etiology; D060787:Neoplasm Grading; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000401:mortality; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology; D062606:Tertiary Care Centers; D013923:Thromboembolism / Q000209:etiology; D016896:Treatment Outcome; D055815:Young Adult
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