title: Cellular and pharmacological targets to induce coronary arteriogenesis.
abstract: The formation of collateral vessels (arteriogenesis) to sustain perfusion in ischemic tissue is native to the body and can compensate for coronary stenosis. However, arteriogenesis is a complex process and is dependent on many different factors. Although animal studies on collateral formation and stimulation show promising data, clinical trials have failed to replicate these results. Further research to the exact mechanisms is needed in order to develop a pharmalogical stimulant. This review gives an overview of recent data in the field of arteriogenesis.
authors: Maurits R
authors: MR
authors: Hollander
authors: Anton J G
authors: AJ
authors: Horrevoets
authors: VU University Medical Center, Department of Cardiology, Room 4D-36, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. N.vanroyen@vumc.nl.
authors: Niels
authors: N
authors: van Royen
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D001920:Bradykinin / Q000502:physiology; D003097:Collateral Circulation / Q000502:physiology*; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003326:Coronary Circulation / Q000502:physiology; D003331:Coronary Vessels / Q000502:physiology; D004195:Disease Models, Animal; D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D051379:Mice; D009000:Monocytes / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology*; D020880:Neuregulins / Q000502:physiology; D053657:Platelet-Rich Plasma / Q000502:physiology; D018002:Receptors, Bradykinin / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D043925:Angiogenesis Inducing Agents; D020533:Angiogenesis Inhibitors; D036341:Intercellular Signaling Peptides and Proteins; D020880:Neuregulins; D018002:Receptors, Bradykinin; D042461:Vascular Endothelial Growth Factor A; D014665:Vasodilator Agents; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D001920:Bradykinin
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