title: The influence of exposure to maternal diabetes in utero on the rate of decline in β-cell function among youth with diabetes.
abstract: Abstract We explored the influence of exposure to maternal diabetes in utero on β cell decline measured by fasting C-peptide (FCP) among 1079 youth <20 years with diabetes, including 941 with type 1 and 138 with type 2 diabetes. Youths exposed to maternal diabetes had FCP levels that were 17% lower among youth with type 2 diabetes [95% confidence interval (CI): -34%, +6%] and 15% higher among youth with type 1 diabetes (95%CI: -14%, +55%) than their unexposed counterparts, although differences were not statistically significant (p=0.13 and p=0.35, respectively). Exposure to maternal diabetes was not associated with FCP decline in youth with type 2 (p=0.16) or type 1 diabetes (p=0.90); nor was the effect of in utero exposure on FCP modified by diabetes type. Findings suggest that exposure to maternal diabetes in utero may not be an important determinant of short-term β-cell function decline in youth with type 1 or type 2 diabetes.
authors: Tessa L
authors: TL
authors: Crume
authors: Jeanette S
authors: JS
authors: Andrews
authors: Ralph B
authors: RB
authors: D'Agostino
authors: David J
authors: DJ
authors: Pettitt
authors: Elizabeth J
authors: EJ
authors: Mayer-Davis
authors: Jennifer R
authors: JR
authors: Law
authors: Lawrence
authors: L
authors: Dolan
authors: Jean M
authors: JM
authors: Lawrence
authors: Sharon
authors: S
authors: Saydah
authors: Carla
authors: C
authors: Greenbaum
authors: Beatriz L
authors: BL
authors: Rodriguez
authors: Dana
authors: D
authors: Dabelea
mesh_terms: D000293:Adolescent; D002096:C-Peptide / Q000097:blood; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D016640:Diabetes, Gestational / Q000503:physiopathology*; D005260:Female; D006801:Humans; D050417:Insulin-Secreting Cells / Q000502:physiology*; D008297:Male; D011247:Pregnancy
chemical_list: D002096:C-Peptide
references: Diabetologia. 2000 Aug;43(8):1000-4
references: 10990077
references: Diabetes Res Clin Pract. 1998 Jul;41(1):9-14
references: 9768367
references: J Pediatr. 2011 Jan;158(1):106-11
references: 20797726
references: Diabetes. 2005 Jun;54(6):1763-9
references: 15919798
references: Diabetes. 1991 Dec;40 Suppl 2:106-8
references: 1748238
references: J Pediatr. 2004 Oct;145(4):439-44
references: 15480363
references: Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E228-36
references: 17389712
references: Lancet. 2003 May 31;361(9372):1861-5
references: 12788573
references: Diabetes Care. 2008 Jul;31(7):1422-6
references: 18375420
references: Lancet. 2001 Nov 24;358(9295):1749-53
references: 11734230
references: Diabetes. 2001 Aug;50(8):1828-33
references: 11473045
references: Int J Biochem Cell Biol. 2006;38(5-6):894-903
references: 16118061
references: Diabetes Care. 1995 May;18(5):611-7
references: 8585997
references: Diabetes. 2000 Dec;49(12):2208-11
references: 11118027
references: J Clin Endocrinol Metab. 2010 Jul;95(7):3360-7
references: 20444913
references: Control Clin Trials. 2004 Oct;25(5):458-71
references: 15465616
references: Am J Obstet Gynecol. 1988 Nov;159(5):1287-92
references: 3056011
references: Lancet. 2000 Aug 12;356(9229):545-9
references: 10950231
references: Diabetes Care. 2008 Nov;31(11):2126-30
references: 18694977
references: Diabetes Care. 2008 Jul;31(7):1403-4
references: 18594062
references: J Clin Endocrinol Metab. 2006 Feb;91(2):401-4
references: 16291705
references: Diabetes Care. 2008 Feb;31(2):340-6
references: 18000174
references: N Engl J Med. 2002 May 30;346(22):1692-8
references: 12037148
references: J Clin Endocrinol Metab. 2011 May;96(5):E803-9
references: 21346075
references: J Clin Endocrinol Metab. 2006 Jan;91(1):185-91
references: 16263830
references: Lancet. 1975 Nov 22;2(7943):1015-6
references: 53499
references: Vital Health Stat 2. 2003 Sep;(135):1-55
references: 14556588
references: Diabetes. 2004 Feb;53(2):426-33
references: 14747294