title: Responses of primate LGN cells to moving stimuli involve a constant background modulation by feedback from area MT.
abstract: The feedback connections from the cortical middle temporal (MT) motion area, to layer 6 of the primary visual cortex (V1), have the capacity to drive a cascaded feedback influence from the layer 6 cortico-geniculate cells back to the lateral geniculate nucleus (LGN) relay cells. This introduces the possibility of a re-entrant motion signal affecting the relay of the retinal input through the LGN to the visual cortex. The question is whether the response of LGN cells to moving stimuli involves a component derived from this feedback. By producing a reversible focal pharmacological block of the activity of an MT direction column we show the presence of such an influence from MT on the responses of magno, parvo and koniocellular cells in the macaque LGN. The pattern of effect in the LGN reflects the direction bias of the MT location inactivated. This suggests a moving stimulus is captured by iterative interactions in the circuit formed by visual cortical areas and visual thalamus.
authors: Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom. hjones@ioores.co.uk
authors: H E
authors: HE
authors: Jones
authors: I M
authors: IM
authors: Andolina
authors: K L
authors: KL
authors: Grieve
authors: W
authors: W
authors: Wang
authors: T E
authors: TE
authors: Salt
authors: J
authors: J
authors: Cudeiro
authors: A M
authors: AM
authors: Sillito
mesh_terms: D000818:Animals; D025461:Feedback, Physiological / Q000502:physiology*; D005260:Female; D005829:Geniculate Bodies / Q000502:physiology*; D008253:Macaca mulatta; D009039:Motion Perception / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods*; D014793:Visual Cortex / Q000502:physiology*
references: Nat Neurosci. 2006 Oct;9(10):1330-6
references: 16980966
references: J Neurosci. 1995 Jul;15(7 Pt 1):4868-74
references: 7623117
references: Vis Neurosci. 1999 Jan-Feb;16(1):1-14
references: 10022474
references: J Neurophysiol. 1966 Nov;29(6):1115-56
references: 4961644
references: Nature. 2008 Nov 20;456(7220):391-4
references: 18849967
references: Vis Neurosci. 2002 Jan-Feb;19(1):97-108
references: 12180863
references: Nat Neurosci. 2000 Sep;3(9):954-9
references: 10966628
references: Science. 2001 Apr 20;292(5516):510-2
references: 11313497
references: J Comp Neurol. 2000 Sep 25;425(3):345-68
references: 10972937
references: J Neurophysiol. 2001 Oct;86(4):2011-28
references: 11600658
references: J Neurosci. 2012 Nov 7;32(45):15946-51
references: 23136432
references: Exp Brain Res. 1979 May 2;35(3):547-57
references: 110614
references: J Neurophysiol. 2002 Nov;88(5):2796-808
references: 12424313
references: J Neurosci. 1983 Dec;3(12):2563-86
references: 6655500
references: Brain Res. 1989 Jul 24;493(1):155-9
references: 2776003
references: Annu Rev Neurosci. 2005;28:157-89
references: 16022593
references: Neuron. 2007 Jun 7;54(5):677-96
references: 17553419
references: Neurol Res. 1979;1(2):203-9
references: 95356
references: Nature. 1998 Aug 20;394(6695):784-7
references: 9723617
references: J Physiol. 1966 Dec;187(3):517-52
references: 16783910
references: Curr Opin Neurobiol. 2008 Aug;18(4):403-7
references: 18805486
references: Trends Neurosci. 2006 Jun;29(6):307-16
references: 16713635
references: Eur J Pharmacol. 1993 Apr 22;235(1):153-5
references: 8390938
references: Nature. 1999 Feb 18;397(6720):610-2
references: 10050853
references: Exp Brain Res. 1987;65(3):582-92
references: 3556486
references: Neuron. 2009 Apr 16;62(1):135-46
references: 19376073
references: J Neurophysiol. 1998 Jun;79(6):3272-8
references: 9636126
references: J Comp Neurol. 1981 Jul 1;199(3):293-326
references: 7263951
references: J Neurophysiol. 1984 Jan;51(1):16-31
references: 6693933
references: Nature. 2001 Feb 22;409(6823):1040-2
references: 11234012
references: Neurosci Biobehav Rev. 2008 Oct;32(8):1409-15
references: 18514901
references: Vis Neurosci. 1994 Mar-Apr;11(2):307-15
references: 7516176
references: Eur J Neurosci. 1989;1(4):309-32
references: 12106142
references: J Physiol. 2011 Jan 1;589(Pt 1):33-40
references: 20724361
references: J Neurosci. 2007 May 16;27(20):5431-6
references: 17507565
references: J Neurosci. 1990 Oct;10(10):3323-34
references: 2213142
references: J Neurophysiol. 2001 Jan;85(1):134-45
references: 11152714
references: Neurosci Biobehav Rev. 2007;31(3):363-76
references: 17141311