title: INDQ/NO, a bioreductively activated nitric oxide prodrug.
abstract: The design, synthesis, and development of INDQ/NO, a novel nitric oxide (NO) prodrug targeted by a bioreductive trigger, are described. INDQ/NO, an indolequinone-diazeniumdiolate is found to be metabolized to produce NO by DT-diaphorase, a bioreductive enzyme that is overexpressed in certain cancers and hypoxic tumors. Cell-based assays revealed that INDQ/NO induces DNA damage and is a potent inhibitor of cancer cell proliferation.
authors: Department of Chemistry, Indian Institute of Science Education and Research Pune, Pune 411 008, Maharashtra, India.
authors: Kavita
authors: K
authors: Sharma
authors: Aishwarya
authors: A
authors: Iyer
authors: Kundan
authors: K
authors: Sengupta
authors: Harinath
authors: H
authors: Chakrapani
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D015195:Drug Design; D006801:Humans; D045563:Indolequinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D009569:Nitric Oxide / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D001388:Aziridines; D045563:Indolequinones; D011355:Prodrugs; D009569:Nitric Oxide; D016660:NAD(P)H Dehydrogenase (Quinone)