title: Modified dachengqi decoction combined with conventional treatment for treating acute exacerbation of chronic obstructive pulmonary disease: a systematic review based on randomized controlled trials.
abstract: Objective. This study intended to systematically evaluate the effectiveness and safety of modified Dachengqi Decoction (MDD) combined with conventional treatment for treating acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Method. An extensive search was performed within 6 English and Chinese electronic databases from inception to April 2012. Methodological quality was assessed according to Cochrane risk of bias assessment. Data were analyzed using Review Manager 5.1. Results. A total of 16 studies (involving 1112 patients) were included. The result showed that MDD and its modification combined with routine treatment were more effective in improving FEV1%pred, enhancing the significant effectiveness, reducing PCO2, and shortening duration of mechanical ventilation. Adverse events were reported in two trials with symptom of diarrhea, while no serious adverse effect was reported. Conclusion. Modified Dachengqi Decoction appears to be effective for treating AECOPD. However, more regular designed RCTs are needed because of insufficient methodological problems.
authors: School of Preclinical Medicine, Beijing University of Chinese Medicine, 11 North Sanhuan East Road, Chaoyang District, Beijing 100029, China.
authors: Ruohan
authors: R
authors: Wu
authors: Zheng
authors: Z
authors: Fengjie
authors: Yuhang
authors: Y
authors: Li
authors: Sun
authors: S
authors: Yan
authors: Liu
authors: L
authors: Miao
authors: Wang
authors: W
authors: Tan
authors: Zhang
authors: Z
authors: Jinchao
references: Control Clin Trials. 1998 Apr;19(2):159-66
references: 9551280
references: Chest. 2009 Mar;135(3):786-793
references: 18812453
references: Respir Med. 2011 Feb;105(2):165-76
references: 21146973
references: Chin J Integr Med. 2010 Apr;16(2):131-7
references: 20473738
references: Chin J Integr Med. 2006 Jun;12(2):122-5
references: 16800991
references: J Intern Med. 2012 May;271(5):481-9
references: 21880073