title: Serum tryptase concentrations in beekeepers with and without Hymenoptera venom allergy.
abstract: BACKGROUND
  Increased tryptase concentrations are a risk marker for the severity of reactions to Hymenoptera stings or venom immunotherapy
  
  
  OBJECTIVE
  To investigate serum tryptase concentrations in beekeepers with and without Hymenoptera venom allergy (HVA).
  
  
  METHODS
  Serum tryptase concentrations were measured in adult patients with HVA (n = 91, 37 of whom were beekeepers), beekeepers without HVA (n = 152), and control individuals from the general adult population (n = 246).
  
  
  RESULTS
  Multivariate analyses revealed that serum tryptase levels were positively associated with beekeeping activities (P < .001) and HVA (P < .001). Tryptase levels were also positively associated with age (P < .001) and male'sex (P = .02), and negatively associated with alcoho consumption (P = .002).
  
  
  CONCLUSIONS
  Beekeeping and HVA are independently associated with increased concentrations of serum tryptase.
authors: Department of Allergy, Hospital Lucus Augusti, Lugo, Spain.
authors: F
authors: F
authors: Carballada
authors: M
authors: M
authors: Alonso
authors: L
authors: L
authors: Vizcaino
authors: V
authors: V
authors: Coutinho
authors: R
authors: R
authors: Núñez
authors: C
authors: C
authors: Vidal
authors: M
authors: M
authors: Boquete
authors: A
authors: A
authors: González-Quintela
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D001180:Arthropod Venoms / Q000276:immunology*; D056630:Beekeeping; D005260:Female; D006801:Humans; D006927:Hymenoptera / Q000276:immunology*; D006967:Hypersensitivity / Q000097:blood* / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D008297:Male; D012307:Risk Factors; D053802:Tryptases / Q000097:blood*
chemical_list: D000485:Allergens; D001180:Arthropod Venoms; D007073:Immunoglobulin E; D053802:Tryptases