title: Targeting allosteric disulphide bonds in cancer.
abstract: Protein action in nature is generally controlled by the amount of protein produced and by chemical modification of the protein, and both are often perturbed in cancer. The amino acid side chains and the peptide and disulphide bonds that bind the polypeptide backbone can be post-translationally modified. Post-translational cleavage or the formation of disulphide bonds are now being identified in cancer-related proteins and it is timely to consider how these allosteric bonds could be targeted for new therapies.
authors: Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney NSW 2052, Australia. p.hogg@unsw.edu.au
authors: Philip J
authors: PJ
authors: Hogg
mesh_terms: D000494:Allosteric Regulation / Q000187:drug effects; D042501:Angiogenic Proteins / Q000378:metabolism; D000818:Animals; D003553:Cystine / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D010084:Oxidation-Reduction; D011499:Protein Processing, Post-Translational
chemical_list: D042501:Angiogenic Proteins; D003553:Cystine
references: Curr Med Chem. 2011;18(20):2995-3014
references: 21651476
references: Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6056-61
references: 21430264
references: Nature. 2000 Apr 27;404(6781):999-1003
references: 10801129
references: J Biol Chem. 2011 Jun 17;286(24):21706-16
references: 21487012
references: J Mol Biol. 2007 Feb 2;365(5):1460-8
references: 17137590
references: Open Biol. 2012 Jan;2(1):110036
references: 22645657
references: Biochem Biophys Res Commun. 1988 Jul 29;154(2):796-802
references: 2456763
references: Antioxid Redox Signal. 2013 May 20;18(15):1987-2015
references: 23198756
references: Science. 2007 Sep 7;317(5843):1393-7
references: 17717153
references: Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9190-5
references: 16754847
references: Cell. 2012 Apr 13;149(2):274-93
references: 22500797
references: J Biol Chem. 2010 Mar 12;285(11):8463-71
references: 20061377
references: Exp Cell Res. 2012 May 15;318(9):1049-56
references: 22410251
references: Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13932-7
references: 16959886
references: Biochim Biophys Acta. 2008 Jan;1784(1):56-65
references: 17905674
references: J Thromb Haemost. 2009 Nov;7(11):1855-64
references: 19624457
references: J Autoimmun. 2012 Sep;39(3):121-9
references: 22704541
references: Mol Cell Biol. 2005 Mar;25(6):2441-9
references: 15743836
references: Neuroscience. 2010 Feb 17;165(4):1312-22
references: 19958818
references: Protein Expr Purif. 2012 Mar;82(1):232-9
references: 22261343
references: Ann N Y Acad Sci. 2008;1131:225-34
references: 18519975
references: Annu Rev Biochem. 2011;80:71-99
references: 21495850
references: Blood. 2012 Jan 26;119(4):924-32
references: 22065595
references: FASEB J. 2011 Sep;25(9):3186-96
references: 21670067
references: J Biol Chem. 1994 Jan 14;269(2):1068-74
references: 8288563
references: J Biol Chem. 2010 Aug 13;285(33):25743-52
references: 20538591
references: N Engl J Med. 2013 Mar 14;368(11):1033-44
references: 23484830
references: Cancer Res. 2005 Jun 1;65(11):4739-46
references: 15930292
references: Mol Biol Evol. 2011 Jan;28(1):327-34
references: 20675408
references: Curr Top Med Chem. 2011 Dec;11(23):2888-905
references: 21824109
references: Curr Opin Chem Biol. 2003 Oct;7(5):580-5
references: 14580561
references: Antioxid Redox Signal. 2011 Jan 1;14(1):113-26
references: 20831445
references: Blood. 2011 Nov 10;118(19):5312-8
references: 21911836
references: J Neurosci Res. 1994 Aug 15;38(6):705-15
references: 7807586
references: Growth Factors. 2010 Oct;28(5):329-50
references: 20476842
references: J Biol Chem. 1989 Dec 15;264(35):20886-93
references: 2480346
references: Antioxid Redox Signal. 2011 Jul 1;15(1):49-66
references: 20849374
references: Blood. 2008 Jan 1;111(1):190-9
references: 17901245
references: Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12021-6
references: 16873552
references: J Biochem. 1988 Aug;104(2):297-305
references: 3141396
references: Nature. 2007 Nov 1;450(7166):124-7
references: 17972886
references: Arthritis Rheum. 2011 Sep;63(9):2774-82
references: 21618459
references: Blood. 2011 Feb 3;117(5):1507-15
references: 21148085
references: Biochemistry. 1996 Jul 30;35(30):9761-7
references: 8703948
references: Blood. 2010 Sep 16;116(11):1995-7
references: 20847215
references: J Thromb Haemost. 2008 Nov;6(11):1908-14
references: 18752581
references: J Biol Chem. 2009 Jun 5;284(23):16037-48
references: 19366703
references: Trends Mol Med. 2011 Jul;17(7):347-62
references: 21481637
references: Nature. 2000 Dec 14;408(6814):869-73
references: 11130727
references: Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6805-10
references: 20351257
references: J Biol Chem. 1991 Dec 25;266(36):24249-52
references: 1722201
references: Blood. 2010 Sep 16;116(11):1961-70
references: 20551379
references: Free Radic Biol Med. 2012 Oct 1;53(7):1522-30
references: 22902630
references: Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2425-30
references: 20145116
references: Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8480-4
references: 11447282
references: BMC Struct Biol. 2007 Jul 20;7:49
references: 17640393
references: J Biol Chem. 2012 Mar 16;287(12):8879-91
references: 22308022
references: Oncogene. 1994 Apr;9(4):1155-61
references: 8134117
references: Nat Rev Drug Discov. 2012 Nov;11(11):873-86
references: 23060265
references: J Biol Chem. 2008 May 30;283(22):15491-501
references: 18390552
references: Nature. 2005 Nov 10;438(7065):248-52
references: 16281040
references: J Immunol. 2006 Jun 1;176(11):6873-8
references: 16709847
references: Trends Biochem Sci. 2003 Apr;28(4):210-4
references: 12713905
references: Nature. 2010 Nov 4;468(7320):108-11
references: 20927107
references: Mol Oncol. 2012 Dec;6(6):579-89
references: 22963873
references: Mol Biol Cell. 2009 Aug;20(16):3628-37
references: 19570911
references: Nat Immunol. 2004 Jan;5(1):74-80
references: 14634646
references: Biochemistry. 2006 Oct 3;45(39):12020-8
references: 17002301
references: Bioessays. 2004 Jan;26(1):73-9
references: 14696043
references: Curr Opin Cell Biol. 2009 Apr;21(2):154-65
references: 19230644
references: Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2597-601
references: 7511815
references: Int J Cancer. 2010 May 15;126(10):2330-40
references: 19795460
references: Biochemistry. 2006 Jun 20;45(24):7429-33
references: 16768438
references: J Biol Chem. 2002 Apr 26;277(17):14351-4
references: 11884384
references: J Biol Chem. 2011 Dec 9;286(49):42257-42266
references: 21994946
references: Open Biol. 2011 Nov;1(3):110010
references: 22645650
references: Nature. 2007 May 24;447(7143):482-6
references: 17495932
references: Arch Biochem Biophys. 2012 Oct 1;526(1):9-15
references: 22743349
references: J Cell Commun Signal. 2011 Jun;5(2):101-10
references: 21484190
references: Oncogene. 1994 Jul;9(7):2037-44
references: 7516063
references: Thromb Res. 2012 Oct;130 Suppl 1:S84-7
references: 23026674
references: J Mol Biol. 1965 May;12:88-118
references: 14343300
references: Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6879-84
references: 10359807
references: J Biol Chem. 2011 Oct 28;286(43):37866-73
references: 21908620
references: Curr Med Chem. 2011;18(35):5424-9
references: 22087835
references: Nat Rev Clin Oncol. 2009 Oct;6(10):587-95
references: 19787002
references: J Thromb Haemost. 2010 Aug;8(8):1754-62
references: 20979592
references: Blood. 2010 Dec 23;116(26):6106-13
references: 20861457
references: Mol Biol Cell. 2007 Oct;18(10):3903-13
references: 17652454
references: Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12445-50
references: 8901601
references: Nat Rev Cancer. 2012 May 24;12(6):387-400
references: 22622641