title: Effect of allergen sensitization on external root resorption.
abstract: In orthodontic tooth movement (OTM), we should be concerned about external root resorption (ERR) as an undesirable iatrogenic problem, but its mechanisms are not fully understood. Since our previous epidemiologic studies found that patients with allergic diseases showed higher rates of ERR during orthodontic treatment, we explored the possible effect of allergic sensitization on ERR. In ovalbumin (OVA)-sensitized Brown-Norway rats, the amounts of ERR and OTM were greater than those in animals subjected to orthodontic force alone. The expression levels of RANKL and pro-inflammatory cytokines were increased in the periodontal tissues of sensitized rats with OTM, compared with control rats. Furthermore, leukotriene B4 (LTB4), a potent lipid mediator of allergic inflammation, and enzymes of the 5-lipoxygenase pathway, the biosynthetic pathway of leukotrienes, were also up-regulated. We found that low doses of aspirin suppressed ERR in allergen-sensitized rats, as well as the expressions of RANKL, pro-inflammatory cytokines, and LTB4. The present findings indicate that allergen sensitization has adverse effects on ERR under OTM, and that aspirin is a potential therapeutic agent for combating ERR.
authors: Department of Molecular Cell Biology and Oral Anatomy, Graduate School of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
authors: N
authors: N
authors: Murata
authors: H
authors: H
authors: Ioi
authors: M
authors: M
authors: Ouchi
authors: T
authors: T
authors: Takao
authors: H
authors: H
authors: Oida
authors: R
authors: R
authors: Aijima
authors: T
authors: T
authors: Yamaza
authors: M A
authors: MA
authors: Kido
mesh_terms: D000485:Allergens / Q000276:immunology*; D000539:Alveolar Process / Q000276:immunology / Q000473:pathology; D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000032:analysis; D001241:Aspirin / Q000494:pharmacology; D001696:Biomechanical Phenomena; D001862:Bone Resorption / Q000276:immunology / Q000473:pathology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004851:Epoxide Hydrolases / Q000032:analysis; D007049:Iatrogenic Disease; D007114:Immunization; D007073:Immunoglobulin E / Q000097:blood; D018836:Inflammation Mediators / Q000032:analysis; D053583:Interleukin-1beta / Q000032:analysis / Q000187:drug effects; D015850:Interleukin-6 / Q000032:analysis; D007975:Leukotriene B4 / Q000032:analysis; D015289:Leukotrienes / Q000032:analysis; D009969:Orthodontic Wires; D010047:Ovalbumin / Q000276:immunology; D010519:Periodontium / Q000276:immunology; D053245:RANK Ligand / Q000032:analysis / Q000187:drug effects; D051381:Rats; D011914:Rats, Inbred BN; D012391:Root Resorption / Q000276:immunology* / Q000517:prevention & control; D014087:Tooth Movement Techniques / Q000009:adverse effects / Q000295:instrumentation; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000187:drug effects; D015854:Up-Regulation
chemical_list: D000485:Allergens; D016861:Cyclooxygenase Inhibitors; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D015850:Interleukin-6; D015289:Leukotrienes; D053245:RANK Ligand; D014409:Tumor Necrosis Factor-alpha; D007975:Leukotriene B4; D007073:Immunoglobulin E; D010047:Ovalbumin; D001094:Arachidonate 5-Lipoxygenase; D004851:Epoxide Hydrolases; D001241:Aspirin; C043134:leukotriene A4 hydrolase
keywords: allergy; aspirin; cytokines; leukotrienes; rats; tooth movement