title: Cinnarizinium bis-(p-toluene-sulfonate) dihydrate.
abstract: THE ASYMMETRIC UNIT OF THE TITLE SALT [SYSTEMATIC NAME: 1-benzhydryl-4-cinnamylpiperazine-1,4-diium bis-(p-toluene-sulfonate) dihydrate], C26H30N2 (2+)·2C7H7O3S(-)·2H2O, consists of a diprotonated cinnarizinium cation hydrogen bonded through two water mol-ecules to two independent p-toluene-sulfonate anions, one which is disordered over two sets of sites in a 0.793 (3):0.207 (3) ratio. In the cation, the piperazine ring adopts a chair configuration and contains two positively charged N atoms with quarternery character. The dihedral angle between the two benzene rings in the benzhydr-yl group is 71.8 (1)°. The benzene ring flanked opposite the piperazine ring is twisted by 75.9 (9) and 8.8 (3)° from these two benzene rings. In the crystal, the [N-H⋯Owater-H⋯O( S)]2 hydrogen-bonded asymmetric unit is connected by further O-H⋯O hydrogen bonds linking the components into chains along [100].
authors: Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India.
authors: C N
authors: CN
authors: Kavitha
authors: Ray J
authors: RJ
authors: Butcher
authors: Jerry P
authors: JP
authors: Jasinski
authors: H S
authors: HS
authors: Yathirajan
authors: A S
authors: AS
authors: Dayananda
references: Acta Crystallogr Sect E Struct Rep Online. 2012 Apr 1;68(Pt 4):o1165-6
references: 22606110
references: J Maine Med Assoc. 1960 Dec;51:454-7
references: 13687289
references: Acta Crystallogr Sect E Struct Rep Online. 2011 Jan 26;67(Pt 2):o500-1
references: 21523154
references: J Laryngol Otol. 1980 Sep;94(9):1009-15
references: 7000939
references: Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22
references: 18156677
references: Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1747
references: 22719532