title: A molecularly defined iron-catalyst for the selective hydrogenation of α,β-unsaturated aldehydes.
abstract: A selective iron-based catalyst system for the hydrogenation of α,β-unsaturated aldehydes to allylic alcohols is presented. Applying the defined iron-tetraphos complex [FeF(L)][BF4] (L = P(PhPPh2)3) in the presence of trifluoroacetic acid a broad range of aldehydes are reduced in high yields using low catalyst loadings (0.05-1 mol %). Excellent chemoselectivity for the reduction of aldehydes in the presence of other reducible moieties, for example, ketones, olefins, esters, etc. is achieved. Based on the in situ detected hydride species [FeH(H2)(L)](+) a catalytic cycle is proposed that is supported by computational calculations.
authors: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany.
authors: Gerrit
authors: G
authors: Wienhöfer
authors: Felix A
authors: FA
authors: Westerhaus
authors: Kathrin
authors: K
authors: Junge
authors: Ralf
authors: R
authors: Ludwig
authors: Matthias
authors: M
authors: Beller
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006865:Hydrogenation; D007501:Iron / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry; D014269:Trifluoroacetic Acid / Q000737:chemistry
chemical_list: D000438:Alcohols; D000447:Aldehydes; D000475:Alkenes; D007659:Ketones; D010720:Phosphines; D007501:Iron; D014269:Trifluoroacetic Acid