title: Association of genetic markers in the BCL-2 family of apoptosis-related genes with endometrial cancer risk in a Chinese population.
abstract: BACKGROUND
  In vitro studies have demonstrated the role of the BCL-2 family of genes in endometrial carcinogenesis. The role of genetic variants in BCL-2 genes and their interactions with non-genetic factors in the development of endometrial cancer has not been investigated in epidemiological studies.
  
  
  METHODS
  We examined the relationship between BCL-2 gene family variants and endometrial cancer risk among 1,028 patients and 1,922 age-matched community controls from Shanghai, China. We also investigated possible interactions between genetic variants and established risk factors (demographic, lifestyle and clinical). Individuals were genotyped for 86 tagging single nucleotide polymorphisms (SNPs) in the BCL2, BAX, BAD and BAK1 genes.
  
  
  RESULTS
  Significant associations with endometrial cancer risk were found for 9 SNPs in the BCL2 gene (P trend<0.05 for all). For SNPs rs17759659 and rs7243091 (minor allele for both: G), the associations were independent. The odds ratio was 1.27 (95% CI: 1.04-1.53) for women with AG genotype for the SNP rs17759659 and 1.82 (95% CI: 1.21-2.73) for women with the GG genotype for the SNP rs7243091. No interaction between these two SNPs and established non-genetic risk factors of endometrial cancer was noticed.
  
  
  CONCLUSIONS
  Genetic polymorphisms in the BCL2 gene may be associated with the risk of endometrial cancer in Chinese women.
authors: Division of Epidemiology, Department of Medicine and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.
authors: Tsogzolmaa
authors: T
authors: Dorjgochoo
authors: Yong-Bing
authors: YB
authors: Xiang
authors: Jirong
authors: J
authors: Long
authors: Jiajun
authors: J
authors: Shi
authors: Sandra
authors: S
authors: Deming
authors: Wang-Hong
authors: WH
authors: Xu
authors: Hui
authors: H
authors: Cai
authors: Jiarong
authors: J
authors: Cheng
authors: Qiuyin
authors: Q
authors: Cai
authors: Wei
authors: W
authors: Zheng
authors: Xiao-Ou
authors: XO
authors: Shu
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D019253:Proto-Oncogene Proteins c-bcl-2
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