title: A collaborative nationwide lymphoma study in Lebanon: incidence of various subtypes and analysis of associations with viruses.
abstract: Incidence of various Hodgkin (HL) and non-Hodgkin lymphoma (NHL) subtypes and association with viruses in Lebanon are not known. We undertook a nationwide study of 272 patients diagnosed with lymphoma in 2007. HL comprised 32.7 % (n = 89) of cases while NHL represented 67.3 % (n = 183). Consistent with the literature, nodular sclerosis was the most predominant HL subtype (n = 57/89). Among NHL, B-cell NHL represented 88 % (n = 161/183), T-cell NHL 9 % (n = 17/183), whereas in 2.7 % it was not classifiable. The B-cell NHL comprised predominantly diffuse large B-cell lymphoma (46 %) and follicular lymphoma (23 %). 81 cases were reviewed by a panel of pathologists with 87.6 % concordance rate. Serology was negative for hepatitis C in 122 tested cases. HIV was positive in 2 cases. Two adult T-cell leukemia/lymphoma were HTLV-I positive. EBV IgG were positive in 88.5 % of cases. 38 EBV seropositive cases [27 NHL (24 B-cell, 3 T-cell) and 11 HL] were studied for EBV genome expression using EBV-encoded RNA (EBER)-in situ hybridization. EBER expression was positive in 8 (21 %) cases (6 HL, 2 T-cell NHL). The distribution of lymphoma subtypes in Lebanon appears similar to that of Western countries. The high rate of EBV positivity in HL and T-cell lymphoma by EBER deserves further investigation.
authors: Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
authors: Zaher K
authors: ZK
authors: Otrock
authors: Jad
authors: J
authors: Saab
authors: Georges
authors: G
authors: Aftimos
authors: Fady
authors: F
authors: Nasr
authors: Fadi S
authors: FS
authors: Farhat
authors: Saad
authors: S
authors: Khairallah
authors: Gérard
authors: G
authors: Abadjian
authors: Marwan
authors: M
authors: Ghosn
authors: Hassan
authors: H
authors: Sidani
authors: Ahmad
authors: A
authors: Ibrahim
authors: Ayman
authors: A
authors: Tawil
authors: Claude
authors: C
authors: Ghorra
authors: Zarouhie
authors: Z
authors: Meguerian
authors: Walid
authors: W
authors: Mokaddem
authors: Walid
authors: W
authors: Dayeh
authors: Ziad
authors: Z
authors: Salem
authors: Georges
authors: G
authors: Chahine
authors: Nizar
authors: N
authors: Bitar
authors: Anas
authors: A
authors: Mugharbel
authors: Joseph
authors: J
authors: Makdessi
authors: Christina
authors: C
authors: Khater
authors: Mirna
authors: M
authors: El Hajj
authors: Dany
authors: D
authors: Abi Gerges
authors: Charles
authors: C
authors: Sfeir
authors: Joseph
authors: J
authors: Kattan
authors: Khaled
authors: K
authors: Ibrahim
authors: Michel
authors: M
authors: Saade
authors: Hussein
authors: H
authors: Sadek
authors: Rami A
authors: RA
authors: Mahfouz
authors: Mohamed A
authors: MA
authors: Kharfan-Dabaja
authors: Ghazi
authors: G
authors: Zaatari
authors: Ali
authors: A
authors: Bazarbachi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D006689:Hodgkin Disease / Q000097:blood / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D006801:Humans; D015994:Incidence; D007861:Lebanon / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014777:Virus Diseases / Q000097:blood / Q000453:epidemiology* / Q000821:virology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral
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