title: Urine Monocyte Chemoattractant Protein-1(UMCP-1) as a Biomarker of Renal Involvement in Systemic Lupus Erythematosus.
abstract: OBJECTIVE
  Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of LN. The study(,)s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UMCP-1) as a biomarker of renal involvement in systemic lupus erythematosus.
  
  
  METHODS
  Forty-one recently diagnosed systemic lupus erythematosus patients (8 male and 33 female) without renal involvement (group 1) and twenty six patients (8 male and 18 female) with LN (group 2), proven by biopsy, were recruited to this study. UMCP-1 sensitivity and specificity for identifying biopsy-proven nephritis were calculated, and a receiver operating characteristic (ROC) curve was constructed to quantify how definitely UMCP-1 distinguishes between patients with and without LN.
  
  
  RESULTS
  The mean value of UMCP-1 levels were 733.07 pg/ml ± 1282.54 and 144.16 pg/ml ± 137.90 in patients with and without LN respectively. The UMCP-1 level was significantly higher in group 2 than group 1. There was no significant correlation between UMCP-1 and 24-hour urine protein (r = 0.031, P= 0.874). The area under the ROC curve was 0.727 with a CI 95% of 0.597 to 0.857 (P=0.002). Using a cut-off value of 82 pg/ml,UMCP-1 had a sensitivity of 88.5% and a specificity of 46.3% for identifying LN.
  
  
  CONCLUSIONS
  UMCP-1 can serve as a biomarker of LN although further longitudinal studies of these biomarkers are required in LN.
authors: Rheumatic Diseases Research Centre (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Zahra
authors: Z
authors: Mirfeizi
authors: Mahmoud
authors: M
authors: Mahmoudi
authors: Masih
authors: M
authors: Naghibi
authors: Mohammmadreza
authors: M
authors: Hatef
authors: Farzaneh
authors: F
authors: Sharifipour
authors: Mohammadhassan
authors: M
authors: Jokar
authors: Abbasali
authors: A
authors: Zeraati
authors: Zhaleh
authors: Z
authors: Shariati Sarabi
authors: Amirabbas
authors: A
authors: Azarian
keywords: Lupus nephritis; Monocyte chemoattractant protein 1; Systemic lupus erythematosus; Urine
references: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005 Aug;27(4):491-5
references: 16178446
references: J Exp Med. 1999 Dec 20;190(12):1813-24
references: 10601356
references: Am J Kidney Dis. 2002 Dec;40(6):1146-52
references: 12460032
references: Arthritis Rheum. 2004 Jun;50(6):1842-9
references: 15188361
references: J Am Soc Nephrol. 2004 Feb;15(2):241-50
references: 14747370
references: Chin Med J (Engl). 2001 Aug;114(8):864-8
references: 11780369
references: Arthritis Rheum. 1997 Sep;40(9):1725
references: 9324032
references: Nephrol Dial Transplant. 2008 Nov;23(11):3521-6
references: 18495743
references: Kidney Int. 1996 Mar;49(3):761-7
references: 8648917
references: Am J Kidney Dis. 1998 Jun;31(6):1065-84
references: 9631856
references: J Am Soc Nephrol. 2005 Feb;16(2):467-73
references: 15601744
references: Springer Semin Immunopathol. 2003 May;24(4):411-21
references: 12778336
references: Lupus. 1998;7(9):597-603
references: 9884096
references: Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3652-6
references: 8170963