title: Desired vancomycin trough serum concentration for treating invasive methicillin-resistant Staphylococcal infections.
abstract: Vancomycin area under the curve/minimal inhibitory concentration (AUC/MIC) >400 best predicts the outcome when treating invasive methicillin-resistant Staphylococcus aureus infection; however, trough serum concentrations are used clinically to assess the appropriateness of dosing. We used pharmacokinetic modeling and simulation to examine the relationship between vancomycin trough values and AUC/MIC in children receiving vancomycin 15 mg/kg every 6 hours and methicillin-resistant Staphylococcus aureus MIC of 1 μg/mL. A trough of 7-10 μg/mL predicted achievement of AUC/MIC >400 in >90% of children.
authors: From the *Department of Pediatrics, Stanford University, Palo Alto, CA; †Department of Clinical Pharmacy, University of California San Francisco, CA; and ‡Department of Pediatrics, University of Utah, Salt Lake City, UT.
authors: Adam
authors: A
authors: Frymoyer
authors: B Joseph
authors: BJ
authors: Guglielmo
authors: Adam L
authors: AL
authors: Hersh
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood* / Q000493:pharmacokinetics; D019540:Area Under Curve; D001835:Body Weight; D002648:Child; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D013203:Staphylococcal Infections / Q000097:blood* / Q000188:drug therapy*; D014640:Vancomycin / Q000008:administration & dosage* / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin