title: Membrane and actin dynamics interplay at lamellipodia leading edge.
abstract: The multimolecular WAVE regulatory (WRC) and Arp2/3 complexes are primarily responsible to generate pushing forces at migratory leading edges by promoting branch elongation of actin filaments. The architectural complexity of these units betrays the necessity to impose a tight control on their activity. This is exerted through temporally coordinated and coincident signals which limit the intensity and duration of this activity. In addition, interactions of the WRC and Arp2/3 complexes with membrane binding and surprisingly membrane trafficking proteins is also emerging, revealing the existence of an 'endocytic wiring system' that spatially restrict branched actin elongation for the execution of polarized functions during cell migration.
authors: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy.
authors: Sara
authors: S
authors: Bisi
authors: Andrea
authors: A
authors: Disanza
authors: Chiara
authors: C
authors: Malinverno
authors: Emanuela
authors: E
authors: Frittoli
authors: Andrea
authors: A
authors: Palamidessi
authors: Giorgio
authors: G
authors: Scita
mesh_terms: D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism; D000199:Actins / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002465:Cell Movement; D006801:Humans; D011554:Pseudopodia / Q000378:metabolism*
chemical_list: D051376:Actin-Related Protein 2-3 Complex; D000199:Actins