title: Noninvasive imaging of myocardial blood flow recovery in response to stem cell intervention.
abstract: The recovery of myocardial blood flow is a major indicator of the effectiveness of cell-based therapies for ischemic heart diseases including myocardial infarction. Blood flow (also called perfusion) of the heart muscle can be noninvasively measured via imaging methods such as ultrasound, positron emission tomography (PET), or magnetic resonance imaging (MRI). Here, we describe an MRI technique, namely, spin labeling, to measure the volumetric blood flow (mL/min/g) in the heart. Specifically, we demonstrate how impaired blood flow in the infarcted region of the heart was recovered transiently (≥ 2 weeks) after the injection of endothelial progenitor cells.
authors: Laboratories of Molecular Imaging, Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors: Hualei
authors: H
authors: Zhang
authors: Rong
authors: R
authors: Zhou
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D002478:Cells, Cultured; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels; D006321:Heart; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009203:Myocardial Infarction / Q000097:blood / Q000473:pathology*; D017202:Myocardial Ischemia / Q000473:pathology; D055420:Perfusion Imaging / Q000379:methods; D051381:Rats; D011923:Rats, Nude; D012039:Regional Blood Flow; D013113:Spin Labels; D013234:Stem Cells / Q000166:cytology
chemical_list: D013113:Spin Labels