title: Brainstem involvement as a cause of central sleep apnea: pattern of microstructural cerebral damage in patients with cerebral microangiopathy.
abstract: BACKGROUND
  The exact underlying pathomechanism of central sleep apnea with Cheyne-Stokes respiration (CSA-CSR) is still unclear. Recent studies have demonstrated an association between cerebral white matter changes and CSA. A dysfunction of central respiratory control centers in the brainstem was suggested by some authors. Novel MR-imaging analysis tools now allow far more subtle assessment of microstructural cerebral changes. The aim of this study was to investigate whether and what severity of subtle structural cerebral changes could lead to CSA-CSR, and whether there is a specific pattern of neurodegenerative changes that cause CSR. Therefore, we examined patients with Fabry disease (FD), an inherited, lysosomal storage disease. White matter lesions are early and frequent findings in FD. Thus, FD can serve as a "model disease" of cerebral microangiopathy to study in more detail the impact of cerebral lesions on central sleep apnea.
  
  
  METHODS
  Genetically proven FD patients (n = 23) and age-matched healthy controls (n = 44) underwent a cardio-respiratory polysomnography and brain MRI at 3.0 Tesla. We applied different MR-imaging techniques, ranging from semiquantitative measurement of white matter lesion (WML) volumes and automated calculation of brain tissue volumes to VBM of gray matter and voxel-based diffusion tensor imaging (DTI) analysis.
  
  
  RESULTS
  In 5 of 23 Fabry patients (22%) CSA-CSR was detected. Voxel-based DTI analysis revealed widespread structural changes in FD patients when compared to the healthy controls. When calculated as a separate group, DTI changes of CSA-CSR patients were most prominent in the brainstem. Voxel-based regression analysis revealed a significant association between CSR severity and microstructural DTI changes within the brainstem.
  
  
  CONCLUSIONS
  Subtle microstructural changes in the brainstem might be a neuroanatomical correlate of CSA-CSR in patients at risk of WML. DTI is more sensitive and specific than conventional structural MRI and other advanced MR analyses tools in demonstrating these abnormalities.
authors: Department of Neurology, University Hospital of Muenster, Muenster, Germany. thomas.duning@ukmuenster.de
authors: Thomas
authors: T
authors: Duning
authors: Michael
authors: M
authors: Deppe
authors: Eva
authors: E
authors: Brand
authors: Jörg
authors: J
authors: Stypmann
authors: Charlotte
authors: C
authors: Becht
authors: Anna
authors: A
authors: Heidbreder
authors: Peter
authors: P
authors: Young
mesh_terms: D000328:Adult; D001933:Brain Stem / Q000473:pathology* / Q000503:physiopathology; D002639:Cheyne-Stokes Respiration / Q000150:complications; D056324:Diffusion Tensor Imaging; D000795:Fabry Disease / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D020182:Sleep Apnea, Central / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*
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