title: Transcatheter aortic valve replacement: an update.
abstract: Aortic stenosis affects many people worldwide with a significant impact on morbidity and mortality with uncorrected, symptomatic aortic valve stenosis carrying mortality of 50% at one year. Degenerative calcific pathology, the most common cause of aortic stenosis, increases in prevalence with age; estimated prevalence of 5% in individuals over 75 years of age. Despite the malignant prognosis without valve replacement, many patients are not offered surgery due to advanced age and co-existing medical conditions; reported to be a third of symptomatic patients. In the last several years, transcatheter aortic valve replacement has emerged as an alternative treatment in patients with high or prohibitive open surgical risk. The PARTNER cohort B data, employing the Sapien valve, demonstrated a 20% absolute mortality benefit at one year compared with medical therapy. In this review, we provide an update of this technology and discuss patient selection, procedural planning, complications, and look toward the future of transcatheter heart valves in the treatment of aortic stenosis.
authors: Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA. sharif.halim@duke.edu
authors: Sharif A
authors: SA
authors: Halim
authors: Todd L
authors: TL
authors: Kiefer
authors: G Chad
authors: GC
authors: Hughes
authors: Lynne M
authors: LM
authors: Hurwitz
authors: J Kevin
authors: JK
authors: Harrison
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001024:Aortic Valve Stenosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D002114:Calcinosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D017023:Coronary Angiography; D005260:Female; D005471:Fluoroscopy; D017408:Guidelines as Topic; D019918:Heart Valve Prosthesis Implantation / Q000379:methods / Q000401:mortality; D006801:Humans; D008297:Male; D018579:Patient Selection; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome
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