title: Central tolerance induction.
abstract: A critical function of the thymus is to help enforce tolerance to self. The importance of central tolerance in preventing autoimmunity has been enlightened by a deeper understanding of the interactions of developing T cells with a diverse population of thymic antigen presenting cell populations. Furthermore, there has been rapid progress in our understanding of how autoreactive T cell specificities are diverted into the T regulatory lineage. Here we review and highlight the recent progress in how tolerance is imposed on the developing thymocyte repertoire.
authors: Diabetes Center, University of California-San Francisco, Box 0540, San Francisco, CA, 94143, USA.
authors: Maria L
authors: ML
authors: Mouchess
authors: Mark
authors: M
authors: Anderson
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000502:physiology; D061167:Central Tolerance; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology*