title: Design and development of reactive injectable and settable polymeric biomaterials.
abstract: Injectable and settable biomaterials are a growing class of therapeutic technologies within the field of regenerative medicine. These materials offer advantages compared to prefabricated implants because of their ability to be utilized as part of noninvasive surgical procedures, fill complex defect shapes, cure in situ, and incorporate cells and other active biologics. However, there are significant technical barriers to clinical translation of injectable and settable biomaterials, such as achieving clinically relevant handling properties and benign reaction conditions. This review focuses on the engineering challenges associated with the design and development of injectable and chemically settable polymeric biomaterials. Additionally, specific examples of the diverse chemistries utilized to overcome these challenges are covered. The future translation of injectable and settable biomaterials is anticipated to improve patient outcomes for a number of clinical conditions.
authors: Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee; Center for Bone Biology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
authors: Jonathan M
authors: JM
authors: Page
authors: Andrew J
authors: AJ
authors: Harmata
authors: Scott A
authors: SA
authors: Guelcher
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000145:classification; D007267:Injections; D008422:Materials Testing; D011108:Polymers / Q000138:chemical synthesis*
chemical_list: D001672:Biocompatible Materials; D011108:Polymers
keywords: biocompatibility; biomaterials; injectable; settable