title: Ask the experts: past, present and future of the rule of five.
abstract: Coined in 1997, by Christopher Lipinki et al., the rule of five (Ro5) comprises a set of parameters that determine drug-likeness for oral delivery. The parameters are as follows: no more than five hydrogen bond donors (nitrogen or oxygen atoms with one or more hydrogen atoms); no more than ten hydrogen bond acceptors (nitrogen or oxygen atoms); a molecular mass less than 500 Da; and an octanol-water partition coefficient log P no greater than 5. Future Medicinal Chemistry invited a selection of leading researchers to express their views on Lipinski's Ro5, which has influenced drug design for over a decade. Their enlightening responses provide an insight into the current and future role of Ro5, and other rules of thumb, in the evolving world of medicinal chemistry.
authors: Jonathan
authors: J
authors: Baell
authors: Miles
authors: M
authors: Congreve
authors: Paul
authors: P
authors: Leeson
authors: Celerino
authors: C
authors: Abad-Zapatero
mesh_terms: D000284:Administration, Oral; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D017408:Guidelines as Topic; D057166:High-Throughput Screening Assays; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000378:metabolism
chemical_list: D001688:Biological Products; D010455:Peptides; D004364:Pharmaceutical Preparations; D054852:Small Molecule Libraries