title: Lymphoepithelioma-like hepatocellular carcinoma: a case report and a review of the literature.
abstract: We report a rare case of lymphoepithelioma-like hepatocellular carcinoma. A 79-year-old Japanese man had undergone curative resection of extrahepatic bile ducts because of bile duct cancer 9 years prior. The bile duct cancer was diagnosed as mucosal adenocarcinoma, and the patient had been followed up every 6 months for the last 9 years. A recent computed tomography examination revealed a tumor, 4.2 cm in size, in the lateral segment of the liver. Based on the imaging findings, the tumor was diagnosed as hepatocellular carcinoma. Serology tests were negative for hepatitis B and C viruses. Chest and abdominal image analyses showed no evidence of metastasis, but a swollen lymph node was noted around the abdominal aorta. The patient subsequently underwent extended lateral segmentectomy and resection of the swollen lymph node. Microscopically, the tumor had the characteristic appearance of poorly differentiated hepatocellular carcinoma. Moreover, an abundant infiltration of inflammatory cells was observed in the tumor. Therefore, we diagnosed the tumor as lymphoepithelioma-like hepatocellular carcinoma. The resected para-aortic lymph node also had a carcinoma with features similar to those of the main tumor. The patient has been alive for 20 months since performance of the surgery. Since the first report of lymphoepithelioma-like hepatocellular carcinoma in 2000, only nine cases have been reported in the medical literature, and the clinicopathological features of the disease have not been well documented. Herein, we describe the clinicopathological features of this case for further understanding of the disease and review past cases in the literature.
authors: Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan. masa02114@yahoo.co.jp
authors: Masahiro
authors: M
authors: Shinoda
authors: Yoshie
authors: Y
authors: Kadota
authors: Hanako
authors: H
authors: Tsujikawa
authors: Yohei
authors: Y
authors: Masugi
authors: Osamu
authors: O
authors: Itano
authors: Akihisa
authors: A
authors: Ueno
authors: Kisho
authors: K
authors: Mihara
authors: Taizo
authors: T
authors: Hibi
authors: Yuta
authors: Y
authors: Abe
authors: Hiroshi
authors: H
authors: Yagi
authors: Minoru
authors: M
authors: Kitago
authors: Shigeyuki
authors: S
authors: Kawachi
authors: Akihiro
authors: A
authors: Tanimoto
authors: Michiie
authors: M
authors: Sakamoto
authors: Minoru
authors: M
authors: Tanabe
authors: Yuko
authors: Y
authors: Kitagawa
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000601:surgery; D000368:Aged; D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000601:surgery; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000601:surgery; D008207:Lymphatic Metastasis; D016246:Lymphocytes, Tumor-Infiltrating / Q000473:pathology*; D008297:Male; D011379:Prognosis; D012196:Review Literature as Topic; D014057:Tomography, X-Ray Computed
references: Hum Pathol. 1996 Aug;27(8):851-3
references: 8760022
references: World J Gastrointest Oncol. 2011 Jul 15;3(7):111-5
references: 21860687
references: Mod Pathol. 1994 Jan;7(1):129-31
references: 7512716
references: Histopathology. 2001 Nov;39(5):540
references: 11737314
references: Hepatology. 1998 Feb;27(2):407-14
references: 9462638
references: Eur J Ophthalmol. 2011 May-Jun;21(3):320-3
references: 21140371
references: J Clin Pathol. 2001 Dec;54(12):964-5
references: 11729219
references: Am J Surg Pathol. 2001 Apr;25(4):516-20
references: 11257627
references: Pathol Res Pract. 2009;205(9):648-52
references: 19217218
references: J Cancer Res Ther. 2009 Oct-Dec;5(4):300-1
references: 20160367
references: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Jan;111(1):78-86
references: 20952226
references: Eur Arch Otorhinolaryngol. 2000;257(7):399-401
references: 11052255
references: Arch Pathol Lab Med. 2008 Apr;132(4):706-9
references: 18384225
references: Arztl Wochensch. 1956 Mar 2;11(8-9):169-82
references: 13326720
references: Am J Clin Pathol. 1998 Jan;109(1):90-5
references: 9426523
references: Hum Pathol. 1996 Aug;27(8):848-50
references: 8760021
references: Histopathology. 2000 Dec;37(6):523-9
references: 11122434
references: Int Urol Nephrol. 2003;35(1):99-106
references: 14620297
references: Int J Immunopathol Pharmacol. 2007 Oct-Dec;20(4):851-4
references: 18179760
references: Int J Urol. 2007 Sep;14(9):851-3
references: 17760754
references: J Low Genit Tract Dis. 2003 Apr;7(2):136-9
references: 17051058
references: Dermatol Online J. 2008 Aug 15;14(8):12
references: 19061572
references: Mod Pathol. 2001 May;14(5):527-32
references: 11353065
references: Mod Pathol. 2007 Aug;20(8):828-34
references: 17541442
references: Chang Gung Med J. 2007 Mar-Apr;30(2):172-7
references: 17596007
references: Pathol Res Pract. 2001;197(8):577-82
references: 11518052
references: Urology. 2005 Nov;66(5):1109
references: 16286140
references: Int J Surg Pathol. 2000 Oct;8(4):347-351
references: 11494016
references: Respirology. 2006 Sep;11(5):539-45
references: 16916325
references: Case Rep Oncol. 2011 Feb 14;4(1):68-73
references: 21475593
references: Dermatol Surg. 2006 Feb;32(2):316-9
references: 16442062
references: Diagn Mol Pathol. 2004 Sep;13(3):183-9
references: 15322431
references: Int J Urol. 2007 Dec;14(12):1093-4
references: 18036048
references: J Low Genit Tract Dis. 2003 Jul;7(3):184-6
references: 17051066
references: Hepatogastroenterology. 1995 Nov-Dec;42(6):996-1001
references: 8847059
references: World J Gastroenterol. 2008 Aug 7;14(29):4694-6
references: 18698686
references: Surg Neurol. 2001 Apr;55(4):232-4
references: 11358599
references: Surg Today. 1999;29(6):542-4
references: 10385369
references: Ann Clin Lab Sci. 2004 Autumn;34(4):476-80
references: 15648792
references: Pathol Int. 2008 Jan;58(1):69-74
references: 18067645
references: Oncology. 2010 Jul;78 Suppl 1:113-24
references: 20616593