title: Pregnancy-related group a streptococcal infections: temporal relationships between bacterial acquisition, infection onset, clinical findings, and outcome.
abstract: Puerperal sepsis caused by group A Streptococcus (GAS) remains an important cause of maternal and infant mortality worldwide, including countries with modern antibiotic regimens, intensive care measures and infection control practices. To provide insights into the genesis of modern GAS puerperal sepsis, we reviewed the published cases and case series from 1974 to 2009, specifically seeking relationships between the likely source of pathogen acquisition, clinical signs, and symptoms at infection onset and patient outcomes that could provide clues for early diagnosis. Results suggest that the pathogenesis of pregnancy-related GAS infections in modern times is complex and not simply the result of exposure to GAS in the hospital setting. Additional research is needed to further explore the source of GAS, the specific M types involved, and the pathogenesis of these pregnancy-related infections to generate novel preventative and therapeutic strategies.
authors: Infectious Diseases Section, Veterans Affairs Medical Center, 500 West Fort St, Boise, ID 83702, USA.
authors: Stephanie M
authors: SM
authors: Hamilton
authors: Dennis L
authors: DL
authors: Stevens
authors: Amy E
authors: AE
authors: Bryant
mesh_terms: D016470:Bacteremia / Q000378:metabolism / Q000382:microbiology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*; D011379:Prognosis; D011645:Puerperal Infection / Q000382:microbiology*; D013290:Streptococcal Infections / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000302:isolation & purification*; D016896:Treatment Outcome
keywords: Streptococcus pyogenes; postpartum sepsis; pregnancy
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