title: Importance of donor ethnicity/race matching in unrelated adult and cord blood allogeneic hematopoietic cell transplant.
abstract: Donor race matching (both recipient and donor belonging to the same race) might be a factor in outcomes of donor allogeneic hematopoietic cell transplant (alloHCT). A total of 858 patients who underwent umbilical cord blood (UCB) (475 patients: 202 double UCB and 273 single UCB) or unrelated donor (URD) (383 patients) alloHCT between January 1995 and December 2010 were studied. Most patients were Caucasian (87%), followed by Asians (4%), African Americans (3%), Hispanics (3%), mixed race (3%) and American Indians (< 1%). Caucasians constituted 88% of the donor grafts; Caucasians were the most common race of the donor grafts among all races except for Asians. As a result, Caucasians were much more likely to have a race-matched donor than ethnic minorities (91% vs. 33%, p < 0.01). Donor race matching did not affect non-relapse mortality, relapse, acute or chronic graft-versus-host disease or overall survival. Acknowledging the limitations of this study (mainly, self-reported race information and small number of ethnic minorities), at present there are no data supporting that donor race should be considered a factor in donor selection.
authors: Division of Hematology, Oncology and Transplantation, Department of Medicine.
authors: Celalettin
authors: C
authors: Ustun
authors: Veronika
authors: V
authors: Bachanova
authors: Ryan
authors: R
authors: Shanley
authors: Margaret L
authors: ML
authors: MacMillan
authors: Navneet S
authors: NS
authors: Majhail
authors: Mukta
authors: M
authors: Arora
authors: Claudio
authors: C
authors: Brunstein
authors: John E
authors: JE
authors: Wagner
authors: Daniel J
authors: DJ
authors: Weisdorf
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D044466:Asian People / Q000706:statistics & numerical data*; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects / Q000208:ethnology* / Q000379:methods; D005260:Female; D006086:Graft vs Host Disease / Q000208:ethnology / Q000209:etiology; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D007198:Indians, North American / Q000706:statistics & numerical data*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data; D016019:Survival Analysis; D014184:Transplantation, Homologous; D061349:Unrelated Donors / Q000706:statistics & numerical data*; D044465:White People / Q000706:statistics & numerical data*; D055815:Young Adult
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