title: [Effects of Chinese wild rice on lipid metabolism and lipotoxicity in rats fed with high fat/cholesterol diet].
abstract: OBJECTIVE
  To study the effects of four kinds of experimental diet, including high fat/cholesterol diet, Chinese wild rice diet, white rice-flour diet and basal diet on the lipotoxicity and disordered lipid metabolism in rats.
  
  
  METHODS
  44 male SD rats were divided into four groups, the basal group, high fat/cholesterol diet group, white rice-flour group and Chinese wild rice group. All rats of four groups were given different diets. Body weights were measured every week, serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), free fatty acids (FFA) and leptin concentrations were measured, and liver pathology were observed.
  
  
  RESULTS
  When compared with the basal diet group, the hyperlipidemic rat model was successfully made in high fat/cholesterol diet group. When compared with the high fat/cholesterol diet group and white rice-flour diet group, the serum TG and TC contents were significantly decreased (P < 0.05), and HDL-C concentration significantly increased (P < 0.05) in Chinese wild rice group. Moreover, Chinese wild rice group had lower contents of serum and liver FFA than those of the high fat/cholesterol diet group and white rice-flour diet group (P < 0.05). Although Chinese wild rice group had a lower serum leptin level than the high fat/cholesterol diet group and white rice-flour diet group, there was no significant differences among the three groups (P > 0.05). The conditions of liver cell fatty degeneration in Chinese wild rice group were slight.
  
  
  CONCLUSIONS
  Compared to the white rice-flour diet, Chinese wild rice could improve the lipid metabolism and liver lipotoxicity of hyperlipidemic rats induced by high fat/cholesterol diet.
authors: Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China. phzhanghong@hotmail.com
authors: Hong
authors: H
authors: Zhang
authors: Shufen
authors: S
authors: Han
authors: Pei
authors: P
authors: Cao
authors: Chengkai
authors: C
authors: Zhai
mesh_terms: D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D059305:Diet, High-Fat / Q000009:adverse effects; D005234:Fatty Liver / Q000517:prevention & control; D005247:Feeding Behavior; D006949:Hyperlipidemias / Q000178:diet therapy* / Q000517:prevention & control*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000473:pathology; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease; D012275:Oryza; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002791:Cholesterol, Dietary; D008055:Lipids