title: Effects of nanotoxicity on female reproductivity and fetal development in animal models.
abstract: The extensive application of nanomaterials in industry, medicine and consumer products has raised concerns about their potential toxicity. The female population is particularly vulnerable and deserves special attention because toxicity in this group may impact both female reproductivity and fetal development. Mouse and zebrafish models each have their own unique features and studies using these models to examine the potential toxicity of various nanoparticles are compared and summarized in this review. Several nanoparticles exhibit detrimental effects on female reproductivity as well as fetal development, and these adverse effects are related to nanoparticle composition, surface modification, dose, exposure route and animal species. Limited studies on the mechanisms of nanotoxicity are also documented and reviewed herein.
authors: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. drbingyan@yahoo.com.
authors: Jianling
authors: J
authors: Sun
authors: Qiu
authors: Q
authors: Zhang
authors: Zhiping
authors: Z
authors: Wang
authors: Bing
authors: B
authors: Yan
mesh_terms: D000818:Animals; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D023421:Models, Animal; D053758:Nanoparticles / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects*; D018675:Toxicity Tests; D015027:Zebrafish / Q000196:embryology
references: J Nanosci Nanotechnol. 2008 Jul;8(7):3603-9
references: 19051917
references: Crit Rev Biochem Mol Biol. 1996 Feb;31(1):1-40
references: 8744954
references: Toxicol Lett. 2009 Feb 25;185(1):1-8
references: 19100318
references: Biochem J. 1998 Jul 15;333 ( Pt 2):291-300
references: 9657968
references: Nat Nanotechnol. 2011 May;6(5):321-8
references: 21460826
references: Toxicol Appl Pharmacol. 2008 May 15;229(1):44-55
references: 18299140
references: J Endocrinol. 2001 Jul;170(1):3-11
references: 11431132
references: J Hazard Mater. 2012 Dec;243:19-27
references: 23131501
references: Mol Nutr Food Res. 2010 Jan;54(1):148-57
references: 19760678
references: Neurosci Biobehav Rev. 2009 Jul;33(7):1061-79
references: 19442688
references: Nano Lett. 2004 Jan 1;4(1):11-18
references: 28890669
references: Aquat Toxicol. 2010 Oct 15;100(2):218-28
references: 20303188
references: Arch Toxicol. 2011 Jul;85(7):787-98
references: 21140132
references: Hum Reprod. 1994 Feb;9(2):188-91
references: 8027271
references: J Am Chem Soc. 2003 Apr 23;125(16):4700-1
references: 12696875
references: Reprod Toxicol. 2007 Jul;24(1):31-41
references: 17548185
references: Environ Toxicol Chem. 2012 Sep;31(9):2117-23
references: 22714141
references: Biochem Pharmacol. 2000 Oct 15;60(8):1075-83
references: 11007944
references: Nanotoxicology. 2013 Feb;7(1):85-96
references: 22117692
references: Fertil Steril. 2010 Mar 15;93(5):1695-9
references: 19446808
references: Environ Sci Technol. 2009 Aug 15;43(16):6349-56
references: 19746736
references: Int J Nanomedicine. 2011;6:343-50
references: 21383859
references: J Reprod Dev. 2009 Dec;55(6):685-90
references: 19789424
references: ACS Nano. 2008 Jul;2(7):1371-80
references: 19206304
references: ACS Nano. 2012 Oct 23;6(10):8767-77
references: 22994679
references: Environ Health Perspect. 2010 Mar;118(3):432-6
references: 20064770
references: Nat Nanotechnol. 2008 Apr;3(4):216-21
references: 18654506
references: Inhal Toxicol. 2007 Mar;19(3):275-81
references: 17365030
references: Part Fibre Toxicol. 2010 Jun 14;7:16
references: 20546558
references: Reprod Toxicol. 2011 Dec;32(4):442-8
references: 21963887
references: Immunol Rev. 2011 Jul;242(1):91-105
references: 21682740
references: Chemosphere. 2011 Apr;83(4):461-7
references: 21239038
references: Nat Rev Drug Discov. 2005 Jan;4(1):35-44
references: 15688071
references: Ann N Y Acad Sci. 1997 Jun 17;816:9-21
references: 9238251
references: Toxicol Appl Pharmacol. 2008 Dec 1;233(2):286-96
references: 18848953
references: Environ Health Perspect. 2003 Feb;111(2):201-5
references: 12573906
references: Toxicol Sci. 2005 Jul;86(1):6-19
references: 15703261
references: Nanoscale. 2009 Oct;1(1):138-52
references: 20644873
references: Zygote. 1996 May;4(2):101-8
references: 8913023
references: J Toxicol Sci. 2011 Aug;36(4):461-8
references: 21804310
references: Environ Sci Technol. 2009 Mar 1;43(5):1605-11
references: 19350942
references: Cancer Cell. 2002 Apr;1(3):229-31
references: 12086858
references: Clin Pharmacol Ther. 2008 May;83(5):761-9
references: 17957183
references: Toxicology. 2009 Oct 1;264(1-2):61-8
references: 19632294
references: Hum Reprod Update. 2003 Nov-Dec;9(6):531-9
references: 14714590
references: Ecotoxicol Environ Saf. 2011 Sep;74(6):1518-25
references: 21513982
references: Part Fibre Toxicol. 2009 Jul 29;6:20
references: 19640265
references: Toxicol Lett. 2010 Aug 16;197(2):82-7
references: 20478369
references: Prog Retin Eye Res. 2008 Jan;27(1):89-110
references: 17962065
references: Part Fibre Toxicol. 2008 Mar 11;5:3
references: 18331653
references: Environ Toxicol. 2005 Aug;20(4):431-40
references: 16007645
references: ACS Nano. 2012 May 22;6(5):3745-59
references: 22482460
references: Nanotoxicology. 2011 Sep;5(3):432-44
references: 21142839
references: J Am Chem Soc. 2003 Oct 22;125(42):12803-9
references: 14558828
references: J Appl Toxicol. 2011 Mar;31(2):95-107
references: 21321970
references: Placenta. 2007 Apr;28 Suppl A:S41-7
references: 17196252
references: Curr Opin Genet Dev. 2000 Jun;10(3):252-6
references: 10826982
references: Inhal Toxicol. 2002 Jun;14(6):635-51
references: 12119073
references: Dev Dyn. 1995 Jul;203(3):253-310
references: 8589427
references: Nano Lett. 2008 Feb;8(2):437-45
references: 18225938
references: Inhal Toxicol. 2009 Jul;21 Suppl 1:92-6
references: 19558239
references: ACS Nano. 2007 Sep;1(2):133-43
references: 19122772
references: J Hazard Mater. 2012 Apr 30;213-214:413-20
references: 22381373
references: Nanotoxicology. 2011 Mar;5(1):43-54
references: 21417687
references: Environ Toxicol Chem. 2007 Apr;26(4):708-16
references: 17447555
references: Int J Nanomedicine. 2012;7:3731-9
references: 22904621
references: Toxicol Lett. 2005 Jan 15;155(1):51-8
references: 15585359
references: J Morphol. 1993 Nov;218(2):203-224
references: 29865471
references: J Toxicol Sci. 2010 Oct;35(5):749-56
references: 20930469
references: Chemosphere. 2012 Sep;89(1):52-9
references: 22595531
references: Environ Sci Technol. 2008 Aug 15;42(16):6264-70
references: 18767697
references: Small. 2010 Mar 8;6(5):670-8
references: 20143348
references: Risk Anal. 2005 Dec;25(6):1621-35
references: 16506988
references: Nanotoxicology. 2013 Mar;7(2):192-201
references: 22263968
references: Acta Pharmacol Sin. 2008 Feb;29(2):259-66
references: 18215357
references: J Environ Sci Health A Tox Hazard Subst Environ Eng. 2008 Feb 15;43(3):278-84
references: 18205059
references: Nat Nanotechnol. 2010 Sep;5(9):683-9
references: 20693989
references: Basic Clin Pharmacol Toxicol. 2011 Dec;109(6):434-7
references: 21699657
references: ACS Nano. 2011 Jun 28;5(6):4476-89
references: 21526751
references: Biomaterials. 2012 Jan;33(2):402-11
references: 22019121
references: Am J Obstet Gynecol. 2011 Jun;204(6):546.e5-9
references: 21481834
references: Small. 2011 Jun 6;7(11):1538-41
references: 21538872
references: Birth Defects Res B Dev Reprod Toxicol. 2011 Feb;92(1):69-76
references: 21254368
references: Nanotoxicology. 2012 Sep;6(6):670-9
references: 21830861
references: FEBS Lett. 1996 Sep 9;393(1):139-45
references: 8804443
references: Nat Med. 2007 Jan;13(1):95-9
references: 17187073
references: Small. 2009 Aug 17;5(16):1897-910
references: 19437466
references: Biochem Pharmacol. 2006 Nov 30;72(11):1493-505
references: 16723122
references: Toxicol Sci. 2012 Apr;126(2):478-86
references: 22240978
references: Langmuir. 2009 Jul 21;25(14):8192-9
references: 19425601
references: Nano Lett. 2007 Dec;7(12):3592-7
references: 18044946
references: ACS Nano. 2011 Jun 28;5(6):4624-33
references: 21615177
references: Carbon N Y. 2007 Aug;45(9):1891-1898
references: 18670586
references: Med Clin North Am. 1990 Mar;74(2):391-411
references: 2181211
references: Inhal Toxicol. 2011 Nov;23(13):805-13
references: 22017524
references: Neurosci Lett. 2009 Jan 2;449(1):38-41
references: 18938223
references: Science. 2005 Jun 3;308(5727):1466-9
references: 15933200
references: J Appl Toxicol. 2010 May;30(4):354-60
references: 20063269
references: J Natl Cancer Inst. 1997 Nov 5;89(21):1602-8
references: 9362158
references: Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):354-66
references: 16081118
references: J Epidemiol Community Health. 2010 Mar;64(3):223-8
references: 19679705
references: Eur Respir J. 2009 Sep;34(3):559-67
references: 19696157