title: Association between major depressive disorder and the norepinephrine transporter polymorphisms T-182C and G1287A: a meta-analysis.
abstract: BACKGROUND
  Previous studies have implicated norepinephrine transporter (NET) gene polymorphisms in the etiology of major depressive disorder (MDD). Recently, two single nucleotide NET polymorphisms, T-182C (rs2242446) in the promoter region and G1287A (rs5569) in exon 9, were found to be associated with MDD in different populations. However, inconsistent and inconclusive results have also been obtained.
  
  
  METHODS
  In this study, we examined whether rs2242446 and rs5569 genetic variants are related to the etiology of MDD using a meta-analysis. Relevant case-control studies were retrieved by database searching and selected according to established inclusion criteria.
  
  
  RESULTS
  Eight articles were identified that tested the relationship between the NET T-182C and/or G1287A polymorphism and MDD. Statistical analyses revealed no significant association between these polymorphisms and MDD (OR=1.23, 95% CI=0.77-1.97, P=0.38 for T-182C; OR=1.00, 95% CI=0.78-1.29, P=0.99 for G1287A).
  
  
  CONCLUSIONS
  The results must be treated with caution because of the small sample sizes of several included studies.
  
  
  CONCLUSIONS
  Our findings suggest that the NET T-182C and G1287A polymorphisms are not susceptibility factors for MDD.
authors: Department of Psychiatry, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
authors: Xiaofeng
authors: X
authors: Zhao
authors: Yinglin
authors: Y
authors: Huang
authors: Hui
authors: H
authors: Ma
authors: Qiu
authors: Q
authors: Jin
authors: Yuan
authors: Y
authors: Wang
authors: Gang
authors: G
authors: Zhu
mesh_terms: D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000235:genetics*; D005091:Exons / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D050484:Norepinephrine Plasma Membrane Transport Proteins
keywords: Gene polymorphism; Major depressive disorder; Meta-analysis; Norepinephrine transporter