title: [Risk factors for hyperuricemia in active and retired employees underwent physical examination].
abstract: OBJECTIVE
  To observe serum uric acid (UA) level distribution and explore risk factors of hyperuricemia (HUA) in a large cohort of active and retired employees underwent physical examination.
  
  
  METHODS
  Physical examination was arranged for 21 700 active and retired employees from May 2010 to September 2011, 16 416 employees were examined and complete examination data were obtained in 14 044 subjects. The distribution characteristics of UA level and correlations of UA level and HUA prevalence rate with gender, age, body mass index (BMI), systolic pressure (SBP), diastolic pressure (DBP), fasting blood-glucose (FPG), serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) were analyzed.
  
  
  RESULTS
  HUA prevalence rate was 11.2% in this cohort, which was significantly higher in males (15.8%) than in females (4.1%, P < 0.05). The UA level and the HUA prevalence rate presented a "J" curve relationship with aging and positively correlated with BMI, SBP, DBP, TG, LDL-C, TC and FPG while negatively correlated with HDL-C. Multiple linear regression analysis showed that SBP, BMI, FPG, TG, and LDL-C were independent risk factors while HDL-C and female gender were the protective factors of HUA(all P < 0.01). Aging and high DBP were independent risk factors of HUA for females (all P < 0.05) and LDL-C was risk factor of HUA for males (P < 0.05).
  
  
  CONCLUSIONS
  Serum UA level presents a "J" wave relationship with aging. The risk factors of HUA are increased SBP, BMI, FPG, TG, LDL-C while the protective factors of HUA are female gender and high HDL-C.
authors: Department of Cardiology, Hubei Aerospace Hospital, Xiaogan, China.
authors: De-fu
authors: DF
authors: Qian
authors: Guo-li
authors: GL
authors: Fan
authors: Ping
authors: P
authors: Chen
authors: Da-chun
authors: DC
authors: He
authors: Jing-dong
authors: JD
authors: Fan
authors: Chi
authors: C
authors: Feng
authors: Pu-guo
authors: PG
authors: Zhu
authors: Zi-hua
authors: ZH
authors: Zhou
authors: Yu-hua
authors: YH
authors: Liao
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D010808:Physical Examination; D015995:Prevalence; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid