title: Structural characteristics and anticancer activity of fucoidan from the brown alga Sargassum mcclurei.
abstract: Three different fucoidan fractions were isolated and purified from the brown alga, Sargassum mcclurei. The SmF1 and SmF2 fucoidans are sulfated heteropolysaccharides that contain fucose, galactose, mannose, xylose and glucose. The SmF3 fucoidan is highly sulfated (35%) galactofucan, and the main chain of the polysaccharide contains a →3)-α-L-Fucp(2,4SO₃⁻)-(1→3)-α-L-Fucp(2,4SO₃⁻)-(1→ motif with 1,4-linked 3-sulfated α-L-Fucp inserts and 6-linked galactose on reducing end. Possible branching points include the 1,2,6- or 1,3,6-linked galactose and/or 1,3,4-linked fucose residues that could be glycosylated with terminal β-D-Galp residues or chains of alternating sulfated 1,3-linked α-L-Fucp and 1,4-linked β-D-Galp residues, which have been identified in galactofucans for the first time. Both α-L-Fucp and β-D-Galp residues are sulfated at C-2 and/or C-4 (and some C-6 of β-D-Galp) and potentially the C-3 of terminal β-D-Galp, 1,4-linked β-D-Galp and 1,4-linked α-L-Fucp residues. All fucoidans fractions were less cytotoxic and displayed colony formation inhibition in colon cancer DLD-1 cells. Therefore, these fucoidan fractions are potential antitumor agents.
authors: Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, 02 Hung Vuong Street, Nhatrang 650000, Socialist Republic of Vietnam. ducthinh.nitra@gmail.com
authors: Pham Duc
authors: PD
authors: Thinh
authors: Roza V
authors: RV
authors: Menshova
authors: Svetlana P
authors: SP
authors: Ermakova
authors: Stanislav D
authors: SD
authors: Anastyuk
authors: Bui Minh
authors: BM
authors: Ly
authors: Tatiana N
authors: TN
authors: Zvyagintseva
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D044647:Sargassum / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D011134:Polysaccharides; C007789:fucoidan
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