title: Metabolic changes one year after laparoscopic adjustable gastric banding operation in morbidly obese subjects.
abstract: BACKGROUND
  Laparoscopic adjustable gastric banding (LAGB) is effective for weight reduction in severely obese patients. However, the data about its effect on metabolic syndrome (MS) are limited.
  
  
  OBJECTIVE
  To assess weight loss and changes of metabolic parameters 1 year after LAGB in a prospective, nonrandomized single center cohort study in morbidly obese subjects.
  
  
  METHODS
  Physical examination, body weight (BW) parameters and metabolic profile were assessed at baseline and 1 year after LAGB in morbidly obese subjects. The incidence of MS was evaluated according to National Cholesterol Education Program Adult Treatment Panel III criteria.
  
  
  RESULTS
  One year after the operation data from 90 patients out of 103 were available. Mean excess weight (EW) loss of 33.1% was associated with a significant improvement in all metabolic parameters: decrease of hypertension by 15.8%, hypertriglyceridemia by 42.6%, and hyperglycemia by 46.3%; and increase in high density lipoprotein cholesterol by 48.3%. This resulted in the resolution of MS in 44.2% of subjects. The significant change in the distribution of MS components was observed with the highest frequency of 4 components before and 2 components after surgery. Patients with MS at baseline lost 29.9% of EW compared to 44.3% in those without MS (p = 0.009).
  
  
  CONCLUSIONS
  The LAGB resulted in effective reduction of BW parameters in morbidly obese subjects 1 year after the operation. Along with the weight loss, resolution of MS and a significant shift towards decrease in the number of MS components was observed. Patients with MS were more resistant to the weight loss.
authors: Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania ; Vilnius University Faculty of Medicine, Vilnius, Lithuania.
authors: Zydrune
authors: Z
authors: Visockiene
authors: Gintautas
authors: G
authors: Brimas
authors: Tomas
authors: T
authors: Abaliksta
authors: Laura
authors: L
authors: Siauliene
authors: Valentina
authors: V
authors: Liakina
authors: Kestutis
authors: K
authors: Strupas
keywords: bariatric surgery; laparoscopic adjustable gastric banding; metabolic syndrome; obesity
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