title: Controlling complexity: the clinical relevance of mouse complex genetics.
abstract: Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.
authors: 1] Department of Infection Genetics, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany [2] University of Veterinary Medicine Hannover, Germany [3] University of Tennessee Health Science Center, Memphis, TN, USA.
authors: Klaus
authors: K
authors: Schughart
authors: Claude
authors: C
authors: Libert
authors: Martien J
authors: MJ
authors: Kas
mesh_terms: D000818:Animals; D035843:Biomedical Research; D006801:Humans; D051379:Mice; D023421:Models, Animal; D059386:Reverse Genetics
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