title: Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus.
abstract: Stimulating encounter: The intimate, physical interaction between the soil-derived bacterium Streptomyces rapamycinicus and the human pathogenic fungus Aspergillus fumigatus led to the activation of an otherwise silent polyketide synthase (PKS) gene cluster coding for an unusual prenylated polyphenol (fumicycline A). The meroterpenoid pathway is regulated by a pathway-specific activator gene as well as by epigenetic factors.
authors: Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Beutenbergstrasse 11a, 07745 Jena, Germany.
authors: Claudia C
authors: CC
authors: König
authors: Kirstin
authors: K
authors: Scherlach
authors: Volker
authors: V
authors: Schroeckh
authors: Fabian
authors: F
authors: Horn
authors: Sandor
authors: S
authors: Nietzsche
authors: Axel A
authors: AA
authors: Brakhage
authors: Christian
authors: C
authors: Hertweck
mesh_terms: D001232:Aspergillus fumigatus / Q000235:genetics / Q000502:physiology*; D018920:Coculture Techniques; D015966:Gene Expression Regulation, Fungal; D008958:Models, Molecular; D005810:Multigene Family; D048630:Polyketide Synthases / Q000235:genetics* / Q000378:metabolism; D061065:Polyketides / Q000378:metabolism; D059808:Polyphenols / Q000378:metabolism; D015398:Signal Transduction; D013302:Streptomyces / Q000502:physiology*
chemical_list: D061065:Polyketides; D059808:Polyphenols; D048630:Polyketide Synthases