title: Fluorescence quenching investigation on the interaction of glutathione-CdTe/CdS quantum dots with sanguinarine and its analytical application.
abstract: Water-soluble glutathione (GSH)-capped core/shell CdTe/CdS quantum dots (QDs) were synthesized. In pH5.4 sodium phosphate buffer medium, the interaction between GSH-CdTe/CdS QDs and sanguinarine (SA) was investigated by spectroscopic methods, including fluorescence spectroscopy and ultraviolet-visible absorption spectroscopy. Addition of SA to GSH-CdTe/CdS QDs results in fluorescence quenching of GSH-CdTe/CdS QDs. Quenching intensity was in proportion to the concentration of SA in a certain range. Investigation of the quenching mechanism, proved that the fluorescence quenching of GSH-CdTe/CdS QDs by SA is a result of electron transfer. Based on the quenching of the fluorescence of GSH-CdTe/CdS QDs by SA, a novel, simple, rapid and specific method for SA determination was proposed. The detection limit for SA was 3.4 ng/mL and the quantitative determination range was 0.2-40.0 µg/mL with a correlation coefficient of 0.9988. The method has been applied to the determination of SA in synthetic samples and fresh urine samples of healthy human with satisfactory results.
authors: School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, People's Republic of China.
authors: Yizhong
authors: Y
authors: Shen
authors: Shaopu
authors: S
authors: Liu
authors: Youqiu
authors: Y
authors: He
mesh_terms: D053119:Benzophenanthridines / Q000032:analysis* / Q000737:chemistry*; D019187:Cadmium Compounds / Q000737:chemistry*; D005453:Fluorescence; D005978:Glutathione / Q000737:chemistry*; D007546:Isoquinolines / Q000032:analysis* / Q000737:chemistry*; D045663:Quantum Dots; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013431:Sulfates / Q000737:chemistry*; D013691:Tellurium / Q000737:chemistry*
chemical_list: D053119:Benzophenanthridines; D019187:Cadmium Compounds; D007546:Isoquinolines; D013431:Sulfates; C037123:cadmium sulfate; C005705:sanguinarine; D005978:Glutathione; D013691:Tellurium; C028337:cadmium telluride
keywords: GSH-CdTe/CdS QDs; fluorescence; quenching, sanguinarine