title: Successful large-volume leukapheresis for hematopoietic stem cell collection in a very-low-weight brain tumor infant with coagulopathy.
abstract: Peripheral apheresis has become a safe procedure to collect hematopoietic stem cells, even in pediatric patients and donors. However, the apheresis procedure for small and sick children is more complicated due to difficult venous access, relatively large extracorporeal volume, toxicity of citrate, and unstable hemostasis. We report a small and sick child with refractory medulloblastoma, impaired liver function, and coagulopathy after several major cycles of cisplatin-based chemotherapy. She successfully received large-volume leukapheresis for hematopoietic stem cell collection, although the patient experienced severe coagulopathy during the procedures. Health care providers should be alert to this potential risk.
authors: Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors: Yu-Mei
authors: YM
authors: Liao
authors: Chi-Jung
authors: CJ
authors: Yeh
authors: Hsiu-Lan
authors: HL
authors: Shu
authors: Pei-Chin
authors: PC
authors: Lin
authors: Tai-Tsung
authors: TT
authors: Chang
authors: Shyh-Shin
authors: SS
authors: Chiou
mesh_terms: D001778:Blood Coagulation Disorders / Q000097:blood*; D002528:Cerebellar Neoplasms / Q000097:blood*; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006801:Humans; D007223:Infant; D007937:Leukapheresis / Q000379:methods*; D008527:Medulloblastoma / Q000097:blood*