title: Fetuin-A levels in hyperthyroidism.
abstract: OBJECTIVE
  Fetuin-A is a protein secreted from the liver that inhibits arterial calcification deposition and can contribute to insulin resistance. Hyperthyroidism is also associated with insulin resistance. It is not known whether hyperthyroidism has an effect on fetuin-A levels.
  
  
  METHODS
  We measured fetuin-A levels and homeostasis model of assessment-insulin resistance before hyperthyroidism treatment was initiated and after euthyroidism was achieved. A total of 42 patients diagnosed with hyperthyroidism were enrolled in this study. Fetuin-A, insulin, high-sensitivity C-reactive protein, fasting blood glucose, free T3 (fT3), free T4 (fT4), and thyrotropin were measured before and after euthyroidism was established.
  
  
  RESULTS
  Basal fasting blood glucose, high-sensitivity C-reactive protein, insulin, c-peptide, homeostasis model of assessment-insulin resistance, fT3, fT4 and fetuin-A levels were significantly decreased after euthyroidism was achieved (Table 1). Basal fasting blood glucose (r:0.407, p:0.008), high-sensitivity C-reactive protein (r:0.523, p<0.0001), insulin (r:0.479, p:0.001), homeostasis model of assessment-insulin resistance (r:0.541, p<0.0001), fT3 (r:0.492, p:0.001) and fT4 (r:0.473, p:0.002) were positively correlated with basal fetuin-A levels. Basal thyrotropin levels were significantly negatively correlated (r:-0.553, p<0.0001) with basal fetuin-A levels.
  
  
  CONCLUSIONS
  Our findings suggest that hyperthyroidism influences fetuin-A levels.
authors: Department of Endocrinology and Metabolism, Izmir Bozyaka Teaching and Research Hospital, Izmir, Turkey. bopamuk@gmail.com
authors: Bariş Onder
authors: BO
authors: Pamuk
authors: Hamiyet
authors: H
authors: Yilmaz
authors: Tugba
authors: T
authors: Topcuoglu
authors: Oktay
authors: O
authors: Bilgir
authors: Ozlem
authors: O
authors: Çalan
authors: Gulseren
authors: G
authors: Pamuk
authors: Derun Taner
authors: DT
authors: Ertugrul
mesh_terms: D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D060749:alpha-2-HS-Glycoprotein / Q000032:analysis*
chemical_list: D001786:Blood Glucose; D060749:alpha-2-HS-Glycoprotein; D013972:Thyrotropin
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