title: Transition metal-α-amino acid complexes with antibiotic activity against Mycobacterium spp.
abstract: Synthetic iridium-, rhodium-, and ruthenium-amino acid complexes with hydrophobic l-amino acids have antibiotic activity against Mycobacterium spp., including Mycobacterium bovis BCG and the rapidly growing species Mycobacterium abscessus and Mycobacterium chelonae. Concentrations of transition metal-amino acid complexes demonstrating hemolysis or cytotoxicity were 10- to 25-fold higher than were the MICs.
authors: Virginia Tech Center for Drug Discovery and Development, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
authors: George W
authors: GW
authors: Karpin
authors: Joseph S
authors: JS
authors: Merola
authors: Joseph O
authors: JO
authors: Falkinham
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D056831:Coordination Complexes / Q000494:pharmacology*; D007495:Iridium / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D012238:Rhodium / Q000737:chemistry / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D007495:Iridium; D012428:Ruthenium; D012238:Rhodium
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