title: Is microvascular decompression surgery a high risk for postoperative nausea and vomiting in patients undergoing craniotomy?
abstract: OBJECTIVE
  Patients undergoing microvascular decompression surgery often experience postoperative nausea and vomiting (PONV). However, there is little information about the incidence of PONV after microvascular decompression. We hypothesized that microvascular decompression is an especially high-risk procedure for PONV in patients undergoing neurosurgery, and investigated risk factors related to PONV after neurosurgery.
  
  
  METHODS
  All patients who underwent craniotomy in our institution during a period of 2 years were investigated retrospectively. Medical charts were reviewed to identify PONV during the 24-h postoperative period and related risk factors. Multivariate logistic regression analysis was conducted to elucidate the impact of microvascular decompression on PONV after craniotomy.
  
  
  RESULTS
  Among 556 craniotomy cases, 350 patients met the inclusion criteria. Multivariate logistic regression analysis showed that microvascular decompression was an independent risk factor for PONV after craniotomy (odds ratio 5.38, 3.02-9.60), in addition to female gender, non-smoker status, amount of intraoperative fentanyl administered, and cerebrovascular surgery.
  
  
  CONCLUSIONS
  In this retrospective study, microvascular decompression surgery was an especially high-risk factor for PONV in patients undergoing craniotomy. It may be necessary to adopt a combination of prophylactic methods to reduce the incidence of PONV after microvascular decompression.
authors: Department of Anesthesiology, Kitano Hospital, 2-4-20 Ogimachi, Kita-ku, Osaka-city, 530-0025, Japan, keita.satohh@gmail.com.
authors: Keita
authors: K
authors: Sato
authors: Seijyu
authors: S
authors: Sai
authors: Takehiko
authors: T
authors: Adachi
mesh_terms: D000768:Anesthesia, General / Q000379:methods; D003399:Craniotomy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D061145:Microvascular Decompression Surgery / Q000009:adverse effects* / Q000379:methods; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects* / Q000379:methods; D020250:Postoperative Nausea and Vomiting / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors
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