title: Association of TGF-β1 +869C/T promoter polymorphism with susceptibility to autoimmune diseases: a meta-analysis.
abstract: Many case-control studies have investigated the role of TGF-β1 gene +869C/T promoter polymorphism in autoimmune diseases, but the results are inconsistent. To clarify this point, we performed a meta-analysis based on all available studies in Pubmed, Elsevier Science Direct, Google Searching, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure. Crude odds ratios (ORs) with 95% confidence intervals were calculated to estimate the strength of the association. A fixed or random effects model was used on the basis of heterogeneity. A total of 21 papers including 2,693 cases and 3,036 controls were considered in the current meta-analysis. These studies encompass two ankylosing spondylitis (AS), eight rheumatoid arthritis (RA), four systemic lupus erythematosus (SLE), and seven systemic sclerosis (SSc). The results showed that TGF-β1 +869C/T promoter polymorphism were associated with susceptibility to RA (CC vs. TT: OR=0.65, 95% CI=0.48-0.88, P=0.005; CC vs. CT+TT: OR=0.56, 95% CI=0.45-0.69, P=0.000; C vs. T: OR=0.81, 95% CI=0.71-0.93, P=0.003). When stratified by race, significant association was observed only in Asian population. However, we failed to reveal the association between this gene promoter polymorphism and AS, SLE, and SSc. Therefore, this meta-analysis suggests a possible association between TGF-β1 +869C/T promoter polymorphism and RA, especially in Asian population.
authors: Medical Genetics Center in Anhui Medical College, Hefei, 230061, China.
authors: Li
authors: L
authors: Zhang
authors: Jun-wei
authors: JW
authors: Yan
authors: Ying-Xin
authors: YX
authors: Wang
authors: Ya-nan
authors: YN
authors: Wan
authors: Jian-ping
authors: JP
authors: Li
authors: Ping
authors: P
authors: Liu
authors: Bin
authors: B
authors: Xu
authors: Bing-xiang
authors: BX
authors: Wang
authors: Wen-jia
authors: WJ
authors: Peng
authors: Fa-ming
authors: FM
authors: Pan
authors: Jing
authors: J
authors: Wang
mesh_terms: D044466:Asian People / Q000235:genetics; D001327:Autoimmune Diseases / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016014:Linear Models; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1
references: Control Clin Trials. 1986 Sep;7(3):177-88
references: 3802833
references: Nat Med. 2001 Aug;7(8):899-905
references: 11479621
references: Am J Epidemiol. 2006 Feb 15;163(4):300-9
references: 16410351
references: Annu Rev Cell Biol. 1990;6:597-641
references: 2177343
references: Med Hypotheses. 2004;62(2):309-17
references: 14962646
references: J Formos Med Assoc. 2005 Aug;104(8):563-70
references: 16193177
references: Cytokine Growth Factor Rev. 2000 Mar-Jun;11(1-2):133-45
references: 10708961
references: Ann Rheum Dis. 2003 Sep;62(9):907-8
references: 12922971
references: Arthritis Rheum. 2000 May;43(5):1068-73
references: 10817561
references: Tissue Antigens. 2007 Nov;70(5):376-82
references: 17711410
references: Hum Mol Genet. 1999 Jan;8(1):93-7
references: 9887336
references: Genes Immun. 2002 Sep;3(6):313-30
references: 12209358
references: Stat Med. 2002 Jun 15;21(11):1539-58
references: 12111919
references: Br J Dermatol. 2002 Sep;147(3):458-63
references: 12207584
references: Autoimmun Rev. 2005 Sep;4(7):450-9
references: 16137611
references: J Rheumatol. 2003 Jul;30(7):1520-3
references: 12858451
references: J Microbiol Immunol Infect. 2004 Jun;37(3):145-52
references: 15221033
references: Somat Cell Mol Genet. 1986 May;12(3):281-8
references: 3459257
references: Nat Immunol. 2001 Sep;2(9):802-9
references: 11526390
references: Ann Rheum Dis. 2002 Sep;61(9):826-8
references: 12176809
references: Kobe J Med Sci. 2007;53(1-2):15-23
references: 17579298
references: Joint Bone Spine. 2009 Jan;76(1):20-3
references: 18693126
references: Arthritis Rheum. 2008 Jul 15;59(7):974-83
references: 18576303
references: Int J Cell Cloning. 1991 Sep;9(5):438-50
references: 1955735
references: BMJ. 1997 Sep 13;315(7109):629-34
references: 9310563
references: Ann Rheum Dis. 2005 Apr;64(4):616-9
references: 15769917
references: Ann Rheum Dis. 2002 Aug;61(8):678-81
references: 12117671
references: Rheumatology (Oxford). 2009 Feb;48(2):113-8
references: 19106168
references: Tissue Antigens. 2004 May;63(5):491-5
references: 15104684
references: Cell Biochem Funct. 2010 Jun;28(4):274-7
references: 20517890
references: Scand J Rheumatol. 2004;33(6):389-94
references: 15794197
references: Rheumatology (Oxford). 2005 Jan;44(1):51-4
references: 15479754
references: J Immunol. 1995 Sep 15;155(6):3205-12
references: 7673733