title: Accuracy of the StatStrip versus SureStep Flexx glucose meter in neonates at risk of hypoglycemia.
abstract: The study was performed to evaluate the accuracy of the StatStrip (SS) and SureStep Flexx (SF) glucose meters compared to plasma glucose in infants at risk for neonatal hypoglycemia and to determine the effect of bilirubin and hematocrit on the results. A prospective cross-sectional study was conducted on 172 venous blood glucose samples from infants who had initial low point-of-care (POC) glucose tests measured simultaneously by SS and SF. Plasma glucose levels were compared to both POC instruments, and the effect of bilirubin and hematocrit levels on mean glucose differences were analysed. Mean (SD) plasma glucose was 2.12 (0.45) mmol/L; (range, 1.11-3.06 mmol/L). Mean (1.96SD) glucose differences of the SS versus SF were 0.21 (0.70) mmol/L and -0.04 (0.78) mmol/L, respectively. SS sensitivity was 94.7 % with an 86.1 % negative predictive value (NPV) at 2.8 mmol/L, while the SF had a 100 % sensitivity and NPV at the same cut-off level. No correlations were identified between mean glucose differences and either hematocrit or bilirubin levels in both glucose meters. Both the SS and SF glucose meters have limited use when compared to plasma glucose. Hence, they can only be employed as screening tools in at-risk neonates with an appropriate, predetermined cut-off level. Hematocrit and bilirubin levels did not affect the accuracy of both devices.
authors: Division of Neonatology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. rkitsommart@hotmail.com
authors: Ratchada
authors: R
authors: Kitsommart
authors: Sopapan
authors: S
authors: Ngerncham
authors: Pimol
authors: P
authors: Wongsiridej
authors: Tharatip
authors: T
authors: Kolatat
authors: Kriang-Sak
authors: KS
authors: Jirapaet
authors: Bosco
authors: B
authors: Paes
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D001774:Blood Chemical Analysis / Q000295:instrumentation*; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000175:diagnosis*; D007231:Infant, Newborn; D008297:Male; D019095:Point-of-Care Systems; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D001786:Blood Glucose
references: Pediatrics. 2011 Mar;127(3):575-9
references: 21357346
references: J Pediatr Endocrinol Metab. 2002 Mar;15(3):319-24
references: 11924935
references: Diabetes Technol Ther. 2008 Apr;10(2):111-20
references: 18260774
references: Clin Biochem. 2010 Jan;43(1-2):186-92
references: 19769953
references: Arch Dis Child Fetal Neonatal Ed. 2004 Jul;89(4):F356-9
references: 15210675
references: Diabetes Care. 1994 Jan;17(1):81-6
references: 8112195
references: Ann Clin Biochem. 2004 Jan;41(Pt 1):43-6
references: 14713384
references: Pediatrics. 2008 Jul;122(1):65-74
references: 18595988
references: Pediatrics. 2000 May;105(5):1141-5
references: 10790476
references: Indian Pediatr. 2012 Aug;49(8):621-5
references: 22317986
references: J Paediatr Child Health. 2012 Apr;48(4):342-6
references: 22112143
references: Pediatrics. 2006 Jun;117(6):2231-43
references: 16740869
references: Pediatrics. 2007 Dec;120(6):1390-401
references: 18055691
references: Pediatrics. 1999 Apr;103(4 Pt 1):724-9
references: 10103293
references: J Midwifery Womens Health. 2001 Sep-Oct;46(5):292-301
references: 11725900
references: Curr Opin Endocrinol Diabetes Obes. 2010 Feb;17(1):20-4
references: 19952738
references: Diabetes Care. 2000 Aug;23(8):1149-53
references: 10937513
references: Pediatr Int. 2011 Apr;53(2):218-23
references: 21501305
references: J Pediatr. 2009 Nov;155(5):612-7
references: 19840614
references: J Trauma. 2008 Jan;64(1):15-20; discussion 20-1
references: 18188093
references: Semin Fetal Neonatal Med. 2005 Aug;10(4):351-61
references: 15922680
references: J Pediatr. 2012 Nov;161(5):787-91
references: 22727868
references: Emerg Med J. 2005 Mar;22(3):177-9
references: 15735263
references: Eur J Pediatr. 2010 Nov;169(11):1387-95
references: 20574734
references: Clin Chim Acta. 2009 Apr;402(1-2):7-13
references: 19167374