title: Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome.
abstract: The prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group. This study assessed the impact on overall survival (OS) and risk of acute myeloid leukemia transformation (AMLt) of chr17 abnormalities in 88 patients with primary MDS. We have compared this group with 1346 patients with primary MDS and abnormal karyotype without chr17 involved. The alterations of chr17 should be considered within group of poor prognosis. The different types of alterations of chromosome 17 behave different prognosis. The study confirms the intermediate prognostic impact of the i(17q), as stated in IPSS-R. The results of the study, however, provide valuable new information on the prognostic impact of alterations of chromosome 17 in complex karyotypes.
authors: Hospital Arnau de Vilanova, Lleida, Spain.
authors: Judit
authors: J
authors: Sánchez-Castro
authors: Víctor
authors: V
authors: Marco-Betés
authors: Xavier
authors: X
authors: Gómez-Arbonés
authors: Leonor
authors: L
authors: Arenillas
authors: David
authors: D
authors: Valcarcel
authors: Teresa
authors: T
authors: Vallespí
authors: Dolors
authors: D
authors: Costa
authors: Benet
authors: B
authors: Nomdedeu
authors: María José
authors: MJ
authors: Jimenez
authors: Isabel
authors: I
authors: Granada
authors: Javier
authors: J
authors: Grau
authors: María T
authors: MT
authors: Ardanaz
authors: Javier
authors: J
authors: de la Serna
authors: Félix
authors: F
authors: Carbonell
authors: José
authors: J
authors: Cervera
authors: Adriana
authors: A
authors: Sierra
authors: Elisa
authors: E
authors: Luño
authors: Carlos J
authors: CJ
authors: Cervero
authors: José
authors: J
authors: Falantes
authors: María J
authors: MJ
authors: Calasanz
authors: José R
authors: JR
authors: González-Porrás
authors: Alicia
authors: A
authors: Bailén
authors: M Luz
authors: ML
authors: Amigo
authors: Guillermo
authors: G
authors: Sanz
authors: Francesc
authors: F
authors: Solé
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult