title: Does preoperative risk for delirium moderate the effects of postoperative pain and opiate use on postoperative delirium?
abstract: OBJECTIVE
  To investigate whether preoperative risk for delirium moderates the effect of postoperative pain and opioids on the development of postoperative delirium.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  University medical center.
  
  
  METHODS
  Patients 65 years of age or older scheduled for major noncardiac surgery.
  
  
  METHODS
  A structured interview was conducted preoperatively and postoperatively to determine the presence of delirium, defined using the Confusion Assessment Method. We first developed a prediction model to determine which patients were at high versus low risk for the development of delirium based on preoperative patient data. We then computed a logistic regression model to determine whether preoperative risk for delirium moderates the effect of postoperative pain and opioids on incident delirium.
  
  
  RESULTS
  Of 581 patients, 40% developed delirium on days 1 or 2 after surgery. Independent preoperative predictors of postoperative delirium included lower cognitive status, a history of central nervous system disease, high surgical risk, and major spine and joint arthroplasty surgery. Compared with the patients at low preoperative risk for developing delirium, the relative risk for postoperative delirium for those in the high preoperative risk group was 2.38 (95% confidence interval: 1.67-3.40). A significant three-way interaction indicates that preoperative risk for delirium significantly moderated the effect of postoperative pain and opioid use on the development of delirium. Among patients at high preoperative risk for development of delirium who also had high postoperative pain and received high opioid doses, the incidence of delirium was 72%, compared with 20% among patients with low preoperative risk, low postoperative pain, and those who received low opioid doses.
  
  
  CONCLUSIONS
  High levels of postoperative pain and using high opioid doses increased risk for postoperative delirium for all patients. The highest incidence of delirium was among patients who had high preoperative risk for delirium and also had high postoperative pain and used high opioid doses.
authors: University of California, San Francisco, CA. Electronic address: leungj@anesthesia.ucsf.edu.
authors: Jacqueline M
authors: JM
authors: Leung
authors: Laura P
authors: LP
authors: Sands
authors: Eunjung
authors: E
authors: Lim
authors: Tiffany L
authors: TL
authors: Tsai
authors: Sakura
authors: S
authors: Kinjo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D003071:Cognition; D003693:Delirium / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009483:Neuropsychological Tests; D010149:Postoperative Pain / Q000188:drug therapy*; D011183:Postoperative Complications / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology*; D057234:Preoperative Period; D012307:Risk Factors; D012495:San Francisco / Q000453:epidemiology
chemical_list: D000701:Analgesics, Opioid
keywords: Delirium; aging; opioids; pain; postoperative; preoperative risk stratification; surgery
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