title: Effect of pre-procedural statin therapy on myocardial no-reflow following percutaneous coronary intervention: a meta analysis.
abstract: BACKGROUND
  Successful revascularization of coronary artery disease, especially ST-elevation myocardial infarction (STEMI), does not always mean optimal myocardial reperfusion in a portion of patients because of no-reflow phenomenon. We hypothesized that statins might attenuate the incidence of myocardial no-reflow when used before percutaneous coronary intervention (PCI). The purpose of this study was to summarize the evidence of pre-procedural statin therapy to reduce myocardial no-reflow after PCI.
  
  
  METHODS
  We searched the MEDLINE, Cochrane, and clinicaltrials.gov databases from inception to October 2012 for clinical trials that examined statin therapy before PCI. We required that studies initiated statins before PCI and reported myocardial no-reflow. A DerSimonian-Laird model was used to construct random-effects summary risk ratios.
  
  
  RESULTS
  In all, 7 studies with 3086 patients met our selection criteria. The use of pre-procedural statins significantly reduced post-procedural no-reflow by 4.2% in all PCI patients (risk ratio (RR) 0.56, 95% confidence interval (CI) 0.35 to 0.90, P = 0.016), and attenuated by 5.0% in non-STEMI patients (RR 0.41, 95% CI 0.18 to 0.94, P = 0.035). This benefit was mainly observed in the early or acute intensive statin therapy populations (RR 0.43, 95% CI 0.26 to 0.71, P = 0.001).
  
  
  CONCLUSIONS
  Acute intensive statin therapy before PCI significantly reduces the hazard of post-procedural no-reflow phenomenon. The routine use of statins before PCI should be considered.
authors: Department of Evidence Based Medicine, Fuwai Hospital and Cardiovascular Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China. greenmountain_709@yahoo.com.cn
authors: Xiang-dong
authors: XD
authors: Li
authors: Yue-jin
authors: YJ
authors: Yang
authors: Yong-chen
authors: YC
authors: Hao
authors: Ying
authors: Y
authors: Yang
authors: Jing-lin
authors: JL
authors: Zhao
authors: Ke-fei
authors: KF
authors: Dou
authors: Dong-feng
authors: DF
authors: Gu
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D054318:No-Reflow Phenomenon / Q000517:prevention & control*; D062645:Percutaneous Coronary Intervention; D017410:Practice Guidelines as Topic
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors