title: Nogo-A represses anatomical and synaptic plasticity in the central nervous system.
abstract: Nogo-A was initially discovered as a myelin-associated growth inhibitory protein limiting axonal regeneration after central nervous system (CNS) injury. This review summarizes current knowledge on how myelin and neuronal Nogo-A and its receptors exert physiological functions ranging from the regulation of growth suppression to synaptic plasticity in the developing and adult intact CNS.
authors: Brain Research Institute, University of Zurich, Switzerland. kempf@hifo.uzh.ch
authors: Anissa
authors: A
authors: Kempf
authors: Martin E
authors: ME
authors: Schwab
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000254:growth & development / Q000293:injuries / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009185:Myelin Proteins / Q000378:metabolism*; D009186:Myelin Sheath / Q000378:metabolism; D009416:Nerve Regeneration; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism*; D000070798:Nogo Proteins; D011956:Receptors, Cell Surface / Q000378:metabolism; D009435:Synaptic Transmission; D020196:Trauma, Nervous System / Q000378:metabolism / Q000473:pathology
chemical_list: D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human; D011956:Receptors, Cell Surface