title: CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration.
abstract: The role of mesenchymal stromal cells (MSCs) in regulating immune responses in the thymus is currently unclear. Here we report the existence and role of a MSC population in the thymus that expresses the pericyte and MSC marker CD248 (endosialin). We show using a CD248-deficient mouse model, that CD248 expression on these cells is required for full post-natal thymus development and regeneration post-Salmonella infection. In CD248(-/-) mice the thymus is hypocellular and regeneration is poorer, with significant loss of all thymocyte populations. This identifies the requirement of CD248 to maintain optimal thymic cellularity post-partum and infection.
authors: Rheumatology Research Group, Institute of Biomedical Research, University of Birmingham, UK ; MRC Centre for Immune Regulation, University of Birmingham, UK.
authors: Siân
authors: S
authors: Lax
authors: Ewan A
authors: EA
authors: Ross
authors: Andrea
authors: A
authors: White
authors: Jennifer L
authors: JL
authors: Marshall
authors: William E
authors: WE
authors: Jenkinson
authors: Clare M
authors: CM
authors: Isacke
authors: David L
authors: DL
authors: Huso
authors: Adam F
authors: AF
authors: Cunningham
authors: Graham
authors: G
authors: Anderson
authors: Christopher D
authors: CD
authors: Buckley
keywords: CD248; Endosialin; MSC; Thymus
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