title: Confirmation of reported aspirin use in community studies: utility of serum thromboxane B2 measurement.
abstract: Aspirin (ASA) is recommended for the prevention of cardiovascular disease; however, the compliance is low. Reported use may not reflect actual use. Serum thromboxane B2 (STxB2) measurement was evaluated to validate reported ASA use. Males aged 45 to 79 years and females aged 55 to 79 years completed a survey and STxB2 measurement (Thromboxane B2 EIA Kit; Cayman Chemical, Ann Arbor, Michigan). The 107 patients were grouped by use of ASA (56 ASA+ and 51 ASA-) and possible interfering medications (INT) such as nonsteroidal anti-inflammatory drugs. The STxB2 levels (ng/mL) were significantly lower in ASA users: ASA+ INT- 3.0 (0.7, 8.4), ASA+ INT+ 2.0 (0.8, 4.9), ASA- INT+ 176 (75, 390), and ASA- INT- 271 (199, 366). The INT use did not cause a significant difference in STxB2 levels. A STxB2 cut point of 25 ng/mL had high sensitivity (94.1%) and specificity (91.1%) for ASA use. The STxB2 was a reliable marker of ASA use and could be used to confirm ASA exposure in population-based health studies.
authors: 1Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
authors: Nicole Dodge
authors: ND
authors: Zantek
authors: Russell V
authors: RV
authors: Luepker
authors: Sue
authors: S
authors: Duval
authors: Karen
authors: K
authors: Miller
authors: Niki
authors: N
authors: Oldenburg
authors: Alan T
authors: AT
authors: Hirsch
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage*; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D013929:Thromboxane B2 / Q000097:blood*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013929:Thromboxane B2; D001241:Aspirin
keywords: NSAID; aspirin; cardiovascular prevention; compliance; nonsteroidal anti-inflammatory drug; thromboxane B2
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