title: Cyclins and cell cycle control in cancer and disease.
abstract: Cyclin D1 overexpression is found in more than 50% of human breast cancers and causes mammary cancer in transgenic mice. Dysregulation of cyclin D1 gene expression or function contributes to the loss of normal cell cycle control during tumorigenesis. Recent studies have demonstrated that cyclin D1 conducts additional specific functions to regulate gene expression in the context of local chromatin, promote cellular migration, and promote chromosomal instability. It is anticipated that these additional functions contribute to the pathology associated with dysregulated cyclin D1 abundance. This article discusses evidence that examines the functional roles that cyclin D1 may play in cancer with an emphasis on other cyclin family members that also may contribute to cancer and disease in a similar fashion.
authors: Thomas Jefferson University, Philadelphia, PA, USA.
authors: Mathew C
authors: MC
authors: Casimiro
authors: Marco
authors: M
authors: Crosariol
authors: Emanuele
authors: E
authors: Loro
authors: Zhiping
authors: Z
authors: Li
authors: Richard G
authors: RG
authors: Pestell
keywords: CIN; cyclin D1; cyclins; migration; stem cells
references: Nature. 1999 Sep 16;401(6750):297-300
references: 10499591
references: EMBO J. 1997 Apr 1;16(7):1638-46
references: 9130709
references: Anticancer Res. 2003 May-Jun;23(3B):2335-8
references: 12894512
references: J Biol Chem. 2012 Jun 29;287(27):22838-53
references: 22589537
references: J Pathol. 2003 Jul;200(3):375-82
references: 12845634
references: EMBO J. 2009 Sep 16;28(18):2786-93
references: 19680222
references: Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4089-94
references: 17360482
references: Nature. 2012 Jan 18;481(7381):287-94
references: 22258607
references: Cancer Res. 2005 Aug 1;65(15):6557-67
references: 16061635
references: J Biol Chem. 2002 Jul 26;277(30):27449-67
references: 11956189
references: J Biol Chem. 2005 Jan 7;280(1):768-76
references: 15509582
references: Cancer Cell. 2012 Oct 16;22(4):438-51
references: 23079655
references: J Cell Biol. 2012 Jan 9;196(1):147-62
references: 22232705
references: Mol Cell Biol. 2004 Sep;24(17):7598-611
references: 15314168
references: Mol Cancer. 2011 Feb 11;10(1):15
references: 21314937
references: Br J Cancer. 2001 Apr 20;84(8):1064-9
references: 11308255
references: Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):1112-6
references: 8430082
references: J Biol Chem. 2002 Jul 12;277(28):25465-73
references: 11980906
references: Oncogene. 1995 Apr 20;10(8):1501-9
references: 7731704
references: Cancer Res. 2002 Nov 1;62(21):6211-7
references: 12414649
references: Cancer Chemother Pharmacol. 2010 Mar;65(4):679-86
references: 19639316
references: Cancer Res. 1999 May 15;59(10):2297-301
references: 10344732
references: Anticancer Res. 2006 Nov-Dec;26(6B):4415-21
references: 17201163
references: J Biol Chem. 2005 Aug 19;280(33):29728-42
references: 15951563
references: Genes Dev. 1995 Oct 1;9(19):2364-72
references: 7557388
references: Cell. 1988 Jul 29;54(3):433-9
references: 3293803
references: EMBO J. 1996 Apr 15;15(8):1877-84
references: 8617234
references: Mol Cell Biol. 2001 Sep;21(18):6254-69
references: 11509668
references: Nat Med. 1995 Dec;1(12):1257-60
references: 7489405
references: Mol Biol Cell. 2003 May;14(5):2005-15
references: 12802071
references: Oncotarget. 2012 Mar;3(3):224-5
references: 22538871
references: J Cell Sci. 2008 Dec 1;121(Pt 23):3853-7
references: 19020303
references: Nat Rev Cancer. 2010 Jan;10(1):59-64
references: 20029424
references: Mol Biol Cell. 2005 Apr;16(4):1850-8
references: 15659654
references: Nat Rev Mol Cell Biol. 2004 Sep;5(9):739-51
references: 15340381
references: Nature. 1990 Apr 5;344(6266):503-8
references: 2138713
references: Hum Pathol. 2008 Jun;39(6):885-94
references: 18400256
references: J Immunol. 2005 Nov 15;175(10):6402-11
references: 16272292
references: Mol Cell Biol. 2006 Jun;26(11):4240-56
references: 16705174
references: Genes Dev. 2011 Oct 15;25(20):2158-72
references: 22012619
references: Cell. 1991 Sep 20;66(6):1197-206
references: 1833066
references: EMBO Rep. 2012 Jun 01;13(6):501-14
references: 22565320
references: Cell. 1991 Sep 20;66(6):1207-16
references: 1833067
references: Cancer Res. 2002 Nov 15;62(22):6414-7
references: 12438226
references: Leuk Lymphoma. 2001 Feb;40(5-6):461-70
references: 11426519
references: EMBO J. 1994 Oct 17;13(20):4816-22
references: 7957050
references: Zahn Mund Kieferheilkd Zentralbl. 1988;76(4):404-8
references: 2970191
references: Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8
references: 12629218
references: Cancer Res. 2010 Mar 1;70(5):2105-14
references: 20179208
references: Cancer Res. 1994 Jan 15;54(2):380-5
references: 7903908
references: EMBO Rep. 2012 Jun 01;13(6):515-27
references: 22614003
references: J Clin Invest. 2012 Apr;122(4):1138-43
references: 22466654
references: Nature. 2001 Jun 28;411(6841):1017-21
references: 11429595
references: EMBO J. 2009 Sep 16;28(18):2777-85
references: 19696736
references: Proc Natl Acad Sci U S A. 1988 May;85(9):3009-13
references: 3283736
references: Oncogene. 2001 May 31;20(25):3290-300
references: 11423978
references: Cell Cycle. 2006 Nov 1;5(21):2440-2
references: 17106256
references: Am J Pathol. 1997 Feb;150(2):705-11
references: 9033283
references: BMC Cancer. 2010 Jul 02;10:350
references: 20598140
references: Mol Cell Biol. 2000 Apr;20(8):2629-34
references: 10733565
references: J Cell Biol. 1999 Oct 18;147(2):295-306
references: 10525536
references: J Exp Ther Oncol. 1996 Mar;1(2):88-94
references: 9414392
references: Genes Dev. 2004 Apr 15;18(8):862-76
references: 15078817
references: Oncogene. 2005 Apr 18;24(17):2776-86
references: 15838514
references: Cell Cycle. 2009 Apr 1;8(7):1062-8
references: 19305161
references: Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9938-43
references: 9707579
references: EMBO J. 1993 Aug;12(8):3123-32
references: 8393783
references: Curr Biol. 2007 Jan 9;17(1):85-91
references: 17208191
references: Cell. 2004 Apr 16;117(2):239-51
references: 15084261
references: Curr Opin Cell Biol. 1989 Apr;1(2):268-74
references: 2576632
references: Br J Haematol. 1996 Dec;95(3):518-23
references: 8943894
references: Int J Cancer. 1995 Jul 4;62(1):25-8
references: 7601562
references: Cell. 1994 Dec 16;79(6):1093-101
references: 8001135
references: Hum Pathol. 2002 Oct;33(10):1006-15
references: 12395374
references: Oncogene. 2005 Jan 20;24(4):552-60
references: 15580303
references: Oncogene. 2002 Mar 27;21(13):2051-7
references: 11960377
references: Biochem Biophys Res Commun. 1998 Jan 26;242(3):529-33
references: 9464250
references: Genes Dev. 2006 Nov 1;20(21):2922-36
references: 17079683
references: J Biol Chem. 2004 Mar 19;279(12):11639-48
references: 14684736
references: Clin Cancer Res. 2010 May 1;16(9):2518-28
references: 20388846
references: Cell. 1997 Feb 7;88(3):405-15
references: 9039267
references: Curr Opin Cell Biol. 2009 Jun;21(3):344-51
references: 19411170
references: EMBO J. 1993 Aug;12(8):3111-21
references: 8344251
references: EMBO J. 1993 Aug;12(8):3133-42
references: 8344252
references: Nature. 2010 Feb 18;463(7283):899-905
references: 20164920
references: Nature. 2010 Jul 1;466(7302):138-42
references: 20596027
references: Mol Cell Biol. 2011 Jan;31(2):248-55
references: 21078875
references: Genetica. 2000;110(1):31-41
references: 11519873
references: Stem Cells. 2010 Feb;28(2):308-17
references: 19967789
references: Trends Genet. 2008 Jun;24(6):289-96
references: 18472177
references: J Biol Chem. 2002 Sep 20;277(38):35140-9
references: 12122006
references: Cancer Sci. 2007 May;98(5):644-51
references: 17359284
references: Cancer Res. 2008 Apr 15;68(8):2652-60
references: 18413732
references: Cancer Cell. 2010 Jan 19;17(1):65-76
references: 20129248
references: Nat Struct Mol Biol. 2006 Jan;13(1):55-62
references: 16327805
references: Mol Biol Cell. 1994 Aug;5(8):921-32
references: 7803859
references: J Natl Cancer Inst. 2008 Jul 16;100(14):1022-36
references: 18612129
references: Nature. 2011 Jun 08;474(7350):230-4
references: 21654808
references: Nat Rev Genet. 2010 Nov;11(11):761-72
references: 20940737
references: Exp Cell Res. 2006 Dec 10;312(20):4181-204
references: 17123511
references: Mol Biol Cell. 2009 Nov;20(22):4777-89
references: 19793917
references: Endocrinology. 2004 Dec;145(12):5439-47
references: 15331580
references: Cancer Res. 2000 Aug 1;60(15):4000-4
references: 10945597
references: Genes Dev. 1998 Nov 15;12(22):3488-98
references: 9832502
references: Histol Histopathol. 2007 Jul;22(7):769-75
references: 17455150
references: Cell. 1996 Jul 26;86(2):263-74
references: 8706131
references: Cancer Res. 1998 Jul 1;58(13):2876-80
references: 9661905
references: Cell. 1998 Nov 25;95(5):717-28
references: 9845373
references: J Biol Chem. 1996 Mar 15;271(11):6050-61
references: 8626390
references: Cancer Res. 2000 Jan 15;60(2):242-4
references: 10667567
references: Cancer Res. 2010 Nov 1;70(21):8802-11
references: 20940395
references: Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8022-6
references: 8058751
references: Cancer Cell. 2006 Jan;9(1):13-22
references: 16413468
references: Oncogene. 2004 Sep 9;23(41):6980-5
references: 15286714
references: Cancer Res. 2006 Oct 15;66(20):9986-94
references: 17047061
references: J Cell Sci. 1994 Oct;107 ( Pt 10):2789-99
references: 7876347
references: J Virol. 2001 Dec;75(23):11336-43
references: 11689614
references: EMBO J. 1995 Oct 16;14(20):5027-36
references: 7588631
references: Mol Cell Biol. 2009 Jan;29(2):315-23
references: 18981214
references: Cancer Res. 2004 Dec 15;64(24):8980-6
references: 15604262
references: Nat Genet. 2006 Sep;38(9):1043-8
references: 16921376
references: Genes Dev. 2010 Oct 15;24(20):2303-16
references: 20952539
references: Cell. 1990 Feb 9;60(3):487-94
references: 1967981
references: J Virol. 1998 Dec;72(12):9881-8
references: 9811724
references: Cancer Res. 2005 Nov 15;65(22):10174-8
references: 16288002
references: Int J Cancer. 2003 Jul 10;105(5):674-80
references: 12740917
references: Blood. 1997 Nov 1;90(9):3707-13
references: 9345056
references: Development. 2002 Mar;129(6):1377-86
references: 11880347
references: Cell Cycle. 2010 Aug 1;9(15):3119-26
references: 20714219
references: Jpn J Cancer Res. 1995 Jul;86(7):617-21
references: 7559076
references: N Engl J Med. 2002 Nov 14;347(20):1566-75
references: 12432043
references: Cell. 2009 Jul 23;138(2):352-65
references: 19592082
references: Int J Cancer. 2011 Mar 1;128(5):1069-79
references: 20473941
references: J Biol Chem. 2010 May 14;285(20):15587-15598
references: 20231280
references: EMBO J. 1989 Oct;8(10):3053-8
references: 2531073
references: Genes Dev. 1998 Mar 1;12(5):755-62
references: 9499409
references: Nature. 2006 Jan 5;439(7072):84-8
references: 16397499
references: Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5367-72
references: 18391197
references: Oncogene. 2011 Apr 21;30(16):1936-46
references: 21242975
references: Prog Growth Factor Res. 1991;3(4):267-77
references: 1839823
references: Cell Death Differ. 2006 Sep;13(9):1475-84
references: 16322753
references: Trends Biochem Sci. 2005 May;30(5):235-9
references: 15896740
references: J Cancer Res Clin Oncol. 1997;123(2):124-7
references: 9030252
references: Nat Commun. 2012;3:1059
references: 22968705
references: Dev Cell. 2002 Sep;3(3):339-50
references: 12361598
references: Cell. 2009 Apr 3;137(1):87-98
references: 19345189
references: Oncogene. 1998 Dec 17;17(24):3093-102
references: 9872325
references: J Pathol. 2004 Aug;203(4):946-52
references: 15258998
references: Genes Dev. 2003 May 15;17(10):1253-70
references: 12756227
references: Nat Rev Cancer. 2011 Jul 07;11(8):558-72
references: 21734724
references: J Biol Chem. 2008 Mar 21;283(12):7721-32
references: 18216018
references: Cell. 2003 Aug 22;114(4):431-43
references: 12941272
references: J Clin Invest. 2012 Mar;122(3):833-43
references: 22307325
references: J Cell Biol. 1994 Oct;127(2):467-78
references: 7929589
references: Cold Spring Harb Perspect Biol. 2011 Jan 01;3(1):a000745
references: 20980439
references: Oncogene. 1999 Aug 12;18(32):4606-15
references: 10467405
references: Neural Dev. 2009 May 05;4:15
references: 19416500
references: EMBO J. 1992 Mar;11(3):961-71
references: 1312467
references: Expert Opin Ther Targets. 2010 Nov;14(11):1199-212
references: 20932174
references: Cell. 2012 May 25;149(5):1023-34
references: 22632967
references: Cell. 2011 Oct 14;147(2):459-74
references: 21963094
references: Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11400-5
references: 13679587
references: Nature. 1995 Mar 16;374(6519):283-7
references: 7533895
references: Mol Endocrinol. 2001 May;15(5):797-811
references: 11328859
references: Cell. 1995 Aug 25;82(4):621-30
references: 7664341
references: Breast Cancer Res. 2008;10(1):203
references: 18304381
references: Trends Biochem Sci. 2005 Nov;30(11):630-41
references: 16236519
references: Trends Genet. 2008 Jun;24(6):280-8
references: 18457900
references: Am J Pathol. 1997 Jan;150(1):15-23
references: 9006317