title: Original nerve growth factor mimetic dipeptide GK-2 limits the manifestations of hemorrhagic stroke in rats.
abstract: The protective effects of a new low-molecular-weight mimetic of nerve growth factor hexamethylene diamide bis-(N-monosuccinyl-L-glutamine-L-lysine; GK-2) were studied on the experimental model of hemorrhagic stroke (intracerebral posttraumatic hematoma) in rats. Intraperitoneal injections of GK-2 in a dose of 1 mg/kg 4 and 24 h after surgery and 24 h before testing the CNS function on days 3, 7, and 14 prevent death of experimental animals, reduce the neurological deficit, and normalized behavior.
authors: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. vkrayneva@mail.ru
authors: V A
authors: VA
authors: Kraineva
authors: T A
authors: TA
authors: Gudasheva
authors: S O
authors: SO
authors: Kotelnikova
authors: T A
authors: TA
authors: Antipova
authors: S B
authors: SB
authors: Seredenin
mesh_terms: D000818:Animals; D004151:Dipeptides / Q000627:therapeutic use*; D004195:Disease Models, Animal; D020300:Intracranial Hemorrhages / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D020932:Nerve Growth Factor; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D020521:Stroke / Q000188:drug therapy* / Q000401:mortality
chemical_list: D004151:Dipeptides; D018696:Neuroprotective Agents; C572946:bis(N-succinyl-glutamyllysin)hexamethylenediamine; D020932:Nerve Growth Factor