title: Effect of xenogenic cortical bone on fracture healing in a canine fracture model.
abstract: The purpose of this study was to investigate the effect of xenogenic cortical bone (XCB) on fracture repair in the canine ulna. The entire group of animals (n = 12) had a transverse resection of 5 mm length at the middle part of the right ulnar diaphysis. In Group A (eight beagles), the fracture was treated with XCB and metal bone screw. In Group B (four beagles), the fracture was treated with metal bone plate and screw. Radiological, micro-computed tomography (micro-CT), histological examination and mechanical testing were employed to evaluate bone healing and reaction of XCB in the host bone. In Group A, bone union was noticed in 6 out of 8 dogs (75%), starting from the 4th week onwards. Micro-CT and histological examinations showed that the XCB was absorbed and incorporated into the host bone. Incorporation of XCB was observed in 7 cases (88%); it started from the 10th week onwards and continued to week 32 after surgery. Biomechanical strength of the bone fracture site was higher in Group A than in Group B, and was similar to that of normal bone. XCB enhances the bone healing process and can be used as absorbable internal fixation for the management of long bone fractures in dogs.
authors: Chonbuk National University Department of Veterinary Surgery, College of Veterinary Medicine and Bio-Safety Research Institute 664-14 Deokjin-Dong Jeonju City 561-756 Korea.
authors: Suyoung
authors: S
authors: Heo
authors: Kyoungmin
authors: K
authors: So
authors: Sehoon
authors: S
authors: Kim
authors: Minsu
authors: M
authors: Kim
authors: Haebeom
authors: H
authors: Lee
authors: Namsoo
authors: N
authors: Kim
mesh_terms: D000818:Animals; D001860:Bone Plates; D004285:Dogs; D005593:Fracture Fixation, Internal; D017102:Fracture Healing; D055114:X-Ray Microtomography