title: Sodium valproate induced tremor in a patient with epilepsy and Down's syndrome.
abstract: Some papers reported the development of adverse drug reactions in patients with Down's syndrome during the treatment with antiepileptic drugs. However, at this time, no data have been published concerning the development of tremor in patients with Down's syndrome treated with sodium valproate. We report a 17-year-old man with epilepsy and Down's syndrome who experienced tremor during the treatment with a low dosage of sodium valproate. The Naranjo probability scale documented a possible association between tremor and sodium valproate. Sodium valproate was changed to lamotrigine with both a rapid improvement of tremor and an optimal control of symptoms. In conclusion we documented that sodium valproate is able to induce in a patient with epilepsy and Down's syndrome, the development of tremor probably through the decreased activity of GABAergic neurotrasmission; however, further studies may be performed in order to validate this observation.
authors: Department of Neuroscience, Neurology Division, Annunziata Hospital, Cosenza, Italy.
authors: Antonio
authors: A
authors: Siniscalchi
authors: Luca
authors: L
authors: Gallelli
authors: Simona
authors: S
authors: Loizzo
authors: Avenoso
authors: A
authors: Tiziana
authors: Emilio
authors: E
authors: Russo
authors: Giovambattista
authors: G
authors: De Sarro
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004314:Down Syndrome / Q000150:complications; D004827:Epilepsy / Q000188:drug therapy; D018682:GABA Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D014202:Tremor / Q000139:chemically induced*; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D018682:GABA Agents; D014635:Valproic Acid