title: Synthesis of tetrasubstituted unsymmetrical 1,4-enediones via copper-promoted autotandem catalysis and air as the oxidant.
abstract: An efficient procedure has been developed for the preparation of tetrasubstituted unsymmetrical 1,4-enediones via copper-promoted autotandem catalysis and air as the oxidant. Various N-nucleophiles are compatible with this reaction, such as morpholine, piperidine, pyrrolidine, arylamines, pyrazole, imidazole, benzimidazole, and benzotriazole. This reaction also has significant advantages in easily available substrates, atom economy, bond-forming efficiency, and environmental benignity.
authors: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, PR China.
authors: Yan
authors: Y
authors: Yang
authors: Fan
authors: F
authors: Ni
authors: Wen-Ming
authors: WM
authors: Shu
authors: Shang-Bo
authors: SB
authors: Yu
authors: Meng
authors: M
authors: Gao
authors: An-Xin
authors: AX
authors: Wu
mesh_terms: D000388:Air; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry*
chemical_list: D007659:Ketones; D016877:Oxidants; D003300:Copper