title: Active stimulation site of nucleus accumbens deep brain stimulation in obsessive-compulsive disorder is localized in the ventral internal capsule.
abstract: Obsessive-compulsive disorder (OCD) is a chronic psychiatric disorder characterized by persistent thoughts and repetitive ritualistic behaviours. Despite optimal cognitive-behavioral and pharmacological therapy, approximately 10 % of patients remain treatment-resistant. Deep brain stimulation (DBS) is being investigated as experimental therapy for treatment-refractory OCD. In the current study, we determined the relationship between anatomical location of active electrode contacts and clinical outcome in 16 OCD patients undergoing bilateral nucleus accumbens (NAc) DBS. We found that most patients actually do not receive active stimulation in the NAc but in the more laterally, anteriorly and dorsally located ventral part of the anterior limb of the internal capsule, ventral ALIC (vALIC). Our nine patients receiving bilateral vALIC DBS improved on average 73 % on their Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) scores, whereas the six patients with their centers of stimulation located otherwise improved on average only 42 %. We therefore propose bilateral vALIC as a promising new DBS target for patients with treatment-refractory OCD. Future studies employing a direct vALIC targeting approach in larger patient numbers are needed to test whether this proposal holds true.
authors: Department of Neurosurgery H2-238, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1005 AZ, Amsterdam, The Netherlands, p.vandenmunckhof@amc.nl.
authors: Pepijn
authors: P
authors: van den Munckhof
authors: D Andries
authors: DA
authors: Bosch
authors: Mariska H M
authors: MH
authors: Mantione
authors: Martijn
authors: M
authors: Figee
authors: Damiaan A J P
authors: DA
authors: Denys
authors: P Richard
authors: PR
authors: Schuurman
mesh_terms: D000328:Adult; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020772:Internal Capsule / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009714:Nucleus Accumbens / Q000502:physiology*; D009771:Obsessive-Compulsive Disorder / Q000473:pathology / Q000628:therapy*; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome