title: Echinocandins in invasive candidiasis.
abstract: We summarise a recent meeting, sponsored by Pfizer Inc., where experts in Asia shared their clinical experience in managing IC. The echinocandins have demonstrated good activity against non-albicans infections and also azole-resistant strains, both preclinically and in recent clinical trials. As well as proving efficacious, echinocandins have a favourable safety profile and are well tolerated, including among inpatient subpopulations, such as transplant recipients and those with renal or hepatic dysfunction. In addition the echinocandins generally have minimal drug-drug interactions, unlike the oral azoles, which have multiple effects on cytochrome P450-mediated drug metabolism. Echinocandins are characterised by a good safety profile, few drug-drug interactions and good susceptibilities. With the increase in potentially azole-resistant non-albicans infections, echinocandins may become the first-line treatment of choice for many patients.
authors: University of Hong Kong, Pokfulam, Hong Kong, China.
authors: John
authors: J
authors: Simon
authors: Hsin-Yun
authors: HY
authors: Sun
authors: Hoe Nam
authors: HN
authors: Leong
authors: Marie Yvette C
authors: MY
authors: Barez
authors: Po-Yen
authors: PY
authors: Huang
authors: Deepak
authors: D
authors: Talwar
authors: Jen-Hsien
authors: JH
authors: Wang
authors: Melor
authors: M
authors: Mansor
authors: Bambang
authors: B
authors: Wahjuprajitno
authors: Atul
authors: A
authors: Patel
authors: Siriporn
authors: S
authors: Wittayachanyapong
authors: B Shoib Mohd
authors: BS
authors: Sany
authors: Sheng-Fong
authors: SF
authors: Lin
authors: George
authors: G
authors: Dimopoulos
mesh_terms: D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D058365:Candidiasis, Invasive / Q000188:drug therapy*; D054714:Echinocandins / Q000009:adverse effects / Q000627:therapeutic use*; D014943:Global Health; D006801:Humans
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins
keywords: Echinocandins; candidaemia; critically ill