title: Exploring the dermal "template effect" and its structure.
abstract: Scar formation is the problem for clinic surgery. Recent studies showed that the scar formation was closely related to the dermal defect. Three-dimensional (3-d) structures of dermal tissues act as a template to modulate cell functions that are essential the regeneration of skin structure and function. The dermal tissue's integrity and continuity is a prerequisite for repair to take place. Loss of the dermal tissue integrity and continuity due to trauma leads to a lack of the template effect, which may be one important mechanism that hinders the recovery of cell function, resulting in scar formation. These studies give us two questions: what is the three-dimensional (3-d) structure of the dermal tissue? How do the tissues form? Up to now, it is well known that the molecular structure of collagen, the micro-structure of microfibril, however, the mesoscopic structure of dermal tissues is still unclear. Our recently rudimentary studies showed the problem might be resolved by phase-contrast micro-tomography with synchrotron radiation, which is likely to open new avenues for further investigations on wound regeneration and skin tissue engineering.
authors: Shanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200025, People's Republic of China. yuzhi.jiang@hotmail.com
authors: Yuzhi
authors: Y
authors: Jiang
authors: Shuliang
authors: S
authors: Lu
mesh_terms: D002921:Cicatrix / Q000503:physiopathology*; D003094:Collagen / Q000648:ultrastructure; D020405:Dermis / Q000033:anatomy & histology* / Q000503:physiopathology; D006801:Humans; D008858:Microscopy, Phase-Contrast / Q000379:methods; D017356:Synchrotrons; D023822:Tissue Engineering / Q000379:methods*; D014945:Wound Healing / Q000502:physiology*; D055114:X-Ray Microtomography / Q000379:methods*
chemical_list: D003094:Collagen
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