title: Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases.
abstract: The rare variant A673T in the amyloid-β precursor protein (APP) gene has been shown to reduce the risk of cognitive impairment. We genotyped the variant in 8721 Asian individuals comprising 552 with Alzheimer's disease and vascular dementia, 790 with Parkinson's disease, and 7379 controls. The A673T variant was absent in all of the subjects. Our finding suggests that the A673T protective variant is not relevant in our Asian population. Studies in other ethnic populations would clarify whether this variant is specific to specific races/ethnicities.
authors: Department of Neurology, Singapore General Hospital, Singapore; National Neuroscience Institute, Singapore, Singapore.
authors: Simon Kang Seng
authors: SK
authors: Ting
authors: Mei-Sian
authors: MS
authors: Chong
authors: Nagaendran
authors: N
authors: Kandiah
authors: Shahul
authors: S
authors: Hameed
authors: Louis
authors: L
authors: Tan
authors: Wing-Lok
authors: WL
authors: Au
authors: Kumar M
authors: KM
authors: Prakash
authors: Ratnagopal
authors: R
authors: Pavanni
authors: Tih-Shih
authors: TS
authors: Lee
authors: Jia-Nee
authors: JN
authors: Foo
authors: Jin-Xin
authors: JX
authors: Bei
authors: Xue-Qing
authors: XQ
authors: Yu
authors: Jian-Jun
authors: JJ
authors: Liu
authors: Yi
authors: Y
authors: Zhao
authors: Wei-Ling
authors: WL
authors: Lee
authors: Eng-King
authors: EK
authors: Tan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000208:ethnology* / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D001208:Asia / Q000208:ethnology; D044466:Asian People / Q000235:genetics; D015331:Cohort Studies; D015140:Dementia, Vascular / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012306:Risk
chemical_list: D016564:Amyloid beta-Protein Precursor
keywords: A673T; Amyloid-beta precursor protein; Dementia