title: Advantages of using molecular coancestry in the removal of introgressed genetic material.
abstract: BACKGROUND
  When introgression of undesired exogenous genetic material occurs in a population intended to remain pure, actions are necessary to recover the original background. It has been shown that genome-wide information can replace pedigree information for different objectives and is a valuable tool in the fields of genetic conservation and breeding. In this simulation study, molecular information provided by 50 000 SNP was used to minimise the molecular coancestry between individuals of an admixed population and the foreign individuals that originally introgressed a native population in order to remove the exogenous DNA.
  
  
  RESULTS
  This management method, which detects the 'purest' individuals to be used as parents for the next generation, allowed recovery of the native genetic background to a great extent in all simulated scenarios. However, it also caused an increase in inbreeding larger than expected because of the lower number of individuals selected as parents and the higher coancestry between them. In scenarios involving several introgression events the method was more efficient than in those involving a single introgression event because part of the genetic information was mixed with the native genetic material for a shorter period.
  
  
  CONCLUSIONS
  Genome-wide information can be used to identify the purest individuals via the minimisation of molecular coancestry between individuals of the admixed and exogenous populations. Removal of the undesired genetic material is more efficient with a molecular-based approach than with a pedigree-based approach.
authors: INIA, Ctra, De La Coruña Km, 7,5, Madrid, 28040, Spain. amador.carmen@inia.es
authors: Carmen
authors: C
authors: Amador
authors: Jesús
authors: J
authors: Fernández
authors: Theo He
authors: TH
authors: Meuwissen
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D005260:Female; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D006824:Hybridization, Genetic; D007178:Inbreeding; D008297:Male; D008957:Models, Genetic; D010375:Pedigree
references: Biochem Genet. 2005 Aug;43(7-8):347-64
references: 16187160
references: Genet Res. 2000 Jun;75(3):331-43
references: 10893869
references: Genet Res. 2001 Jun;77(3):285-92
references: 11486511
references: Meat Sci. 2007 Dec;77(4):437-49
references: 22061927
references: Trends Ecol Evol. 2004 Sep;19(9):489-96
references: 16701312
references: Science. 2004 May 21;304(5674):1160-4
references: 15155949
references: Trends Ecol Evol. 1995 Jul;10(7):267-70
references: 21237034
references: Nat Genet. 2010 Jul;42(7):565-9
references: 20562875
references: Nat Methods. 2008 Mar;5(3):247-52
references: 18297082
references: J Anim Sci. 2002 Apr;80(4):942-50
references: 12002331
references: J Anim Breed Genet. 2011 Dec;128(6):473-81
references: 22059581
references: Nat Rev Genet. 2011 Jun 17;12(7):499-510
references: 21681211
references: PLoS One. 2012;7(11):e49409
references: 23152901
references: Mol Ecol. 2008 Jan;17(1):275-84
references: 17927711
references: Genet Res (Camb). 2009 Feb;91(1):47-60
references: 19220931
references: Genet Sel Evol. 2012 Nov 15;44:34
references: 23153196
references: J Anim Breed Genet. 2011 Dec;128(6):456-64
references: 22059579
references: BMC Bioinformatics. 2010 Oct 22;11:529
references: 20969788