title: Practical strategies for enhancing adherence to treatment regimen in inflammatory bowel disease.
abstract: Promoting adherence to treatment among pediatric and adult patients with inflammatory bowel disease (IBD) is a critical yet challenging task for health care providers. Several existing interventions to enhance adherence among individuals with IBD offer useful information about practical strategies to enhance adherence. The current review article has 3 goals. First, the review provides a context for understanding treatment regimen adherence in IBD by reviewing key definitional, measurement, and conceptual challenges in this area. Next, published studies focused on interventions to enhance adherence in IBD are briefly summarized, followed by a synthesis of practical adherence promotion strategies for use in IBD by health care providers. Strategies are distinguished by the level of evidence supporting their utility as well as by age group. Finally, recommendations for future research to facilitate the development and implementation of practical, evidence-based strategies for adherence promotion in IBD are provided. Findings from the literature review suggest that strategies including education, regimen simplification, and use of reminder systems and organizational strategies (e.g., pill boxes) are likely to be best suited for addressing accidental nonadherence. In contrast, addressing motivational issues, teaching problem-solving skills, and addressing problematic patterns of family functioning are more likely to benefit individuals displaying intentional nonadherence.
authors: Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA. rachel.greenley@rosalindfranklin.edu
authors: Rachel N
authors: RN
authors: Greenley
authors: Jennifer H
authors: JH
authors: Kunz
authors: Jennifer
authors: J
authors: Walter
authors: Kevin A
authors: KA
authors: Hommel
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D055118:Medication Adherence; D010353:Patient Education as Topic; D011379:Prognosis; D017010:Reminder Systems; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000893:Anti-Inflammatory Agents; D014409:Tumor Necrosis Factor-alpha
references: J Clin Pharm Ther. 1992 Oct;17(5):283-95
references: 1464632
references: Am J Gastroenterol. 2003 Jul;98(7):1535-44
references: 12873575
references: Rev Esp Enferm Dig. 2005 Apr;97(4):249-57
references: 15982180
references: Ann Fam Med. 2004 Sep-Oct;2(5):455-61
references: 15506581
references: Aliment Pharmacol Ther. 2003 Jul 15;18(2):191-8
references: 12869079
references: Aliment Pharmacol Ther. 2008 Jun;27(12):1157-66
references: 18384664
references: J Pediatr Gastroenterol Nutr. 2007 Feb;44(2):180-4
references: 17255828
references: Patient Prefer Adherence. 2012;6:127-35
references: 22379363
references: Inflamm Bowel Dis. 2010 Jan;16(1):36-41
references: 19434722
references: Am J Gastroenterol. 2001 Oct;96(10):2929-33
references: 11693328
references: Pediatrics. 2012 Feb;129(2):e473-85
references: 22218838
references: Can J Gastroenterol. 2005 Apr;19(4):235-44
references: 15861266
references: Gut. 2010 Dec;59(12):1652-61
references: 21071584
references: Clin Ther. 2001 Aug;23(8):1296-310
references: 11558866
references: Clin Ther. 1984;6(5):592-9
references: 6383611
references: Gastroenterol Hepatol (N Y). 2008 Nov 1;4(11):785
references: 20119513
references: J Pediatr Psychol. 1990 Aug;15(4):477-92
references: 2258796
references: J Pediatr Gastroenterol Nutr. 2011 Oct;53(4):435-9
references: 21519282
references: J Pediatr Psychol. 2010 Nov;35(10):1168-77
references: 20444852
references: Am J Med. 2003 Jan;114(1):39-43
references: 12543288
references: Inflamm Bowel Dis. 2011 Sep;17(9):1874-81
references: 21830265
references: J Pediatr Psychol. 2010 Jul;35(6):683-91
references: 19776229
references: J Health Psychol. 2005 May;10(3):443-55
references: 15857873
references: Inflamm Bowel Dis. 2005 Nov;11(11):1006-12
references: 16239847
references: J Assoc Nurses AIDS Care. 2003 Mar-Apr;14(2):52-62
references: 12698766
references: J Pediatr Psychol. 2008 Jul;33(6):590-611
references: 18192300
references: Dig Dis Sci. 2008 Apr;53(4):1020-4
references: 17934828
references: Dig Dis Sci. 2007 Feb;52(2):357-64
references: 17211702
references: Am J Gastroenterol. 2007 Jul;102(7):1417-26
references: 17437505
references: J Pediatr Psychol. 2011 Jan;36(1):116-25
references: 20498007
references: Adv Ther. 2009 Oct;26(10):936-46
references: 19838649
references: J Am Pharm Assoc (2003). 2003 Nov-Dec;43(6):668-78; quiz 678-9
references: 14717263
references: J Clin Gastroenterol. 2001 Jan;32(1):66-8
references: 11154175
references: Eur J Gastroenterol Hepatol. 2012 Jan;24(1):64-9
references: 21989119
references: Inflamm Bowel Dis. 2009 Apr;15(4):589-93
references: 18985746
references: Inflamm Bowel Dis. 2007 Oct;13(10):1244-9
references: 17538983
references: J Clin Psychol. 2009 Nov;65(11):1232-45
references: 19739205
references: Aliment Pharmacol Ther. 2010 Nov;32(9):1051-8
references: 20815833
references: J Pediatr Psychol. 2008 Sep;33(8):867-74
references: 18337262
references: Drugs. 2008;68(18):2601-9
references: 19093702
references: Inflamm Bowel Dis. 2012 Jul;18(7):1254-9
references: 22689633
references: Patient Educ Couns. 2010 Nov;81(2):182-6
references: 20079598
references: Soc Sci Med. 1992 Mar;34(5):507-13
references: 1604357
references: J Pediatr Psychol. 2006 Jun;31(5):501-11
references: 16002481
references: Aliment Pharmacol Ther. 2008 Jan 15;27(2):166-72
references: 17949472
references: Clin Gastroenterol Hepatol. 2003 May;1(3):170-3
references: 15017487
references: Eur J Gastroenterol Hepatol. 2011 Mar;23(3):250-4
references: 21304318
references: J Pediatr Psychol. 2008 Oct;33(9):916-36; discussion 937-8
references: 17846042
references: Diabetes Care. 1997 Jan;20(1):52-4
references: 9028693
references: N Engl J Med. 2005 Aug 4;353(5):487-97
references: 16079372
references: J Pediatr Psychol. 2012 Apr;37(3):282-91
references: 22080456
references: J Pediatr Psychol. 2010 Oct;35(9):1005-10
references: 20026567
references: Inflamm Bowel Dis. 2012 Jun;18(6):1018-25
references: 21688350
references: West J Nurs Res. 2012 Aug;34(5):598-620
references: 22101392
references: Dig Dis Sci. 2006 Dec;51(12):2165-9
references: 17086434