title: Selective synthesis of 1,2-cis-α-glycosides without directing groups. Application to iterative oligosaccharide synthesis.
abstract: A method for the highly selective synthesis of 1,2-cis-α-linked glycosides that does not require the use of the specialized protecting group patterns normally employed to control diastereoselectivity is described. Thioglycoside acceptors can be used, permitting iterative oligosaccharide synthesis. The approach eliminates the need for lengthy syntheses of monosaccharides possessing highly specialized and unconventional protecting group patterns.
authors: Department of Chemistry, Tufts University , 62 Talbot Avenue, Medford, Massachusetts 02145, United States.
authors: An-Hsiang Adam
authors: AH
authors: Chu
authors: Son Hong
authors: SH
authors: Nguyen
authors: Jordan A
authors: JA
authors: Sisel
authors: Andrei
authors: A
authors: Minciunescu
authors: Clay S
authors: CS
authors: Bennett
mesh_terms: D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006027:Glycosides; D009844:Oligosaccharides