title: A novel domino strategy for forming poly-substituted quaternary imidazoles through a Cs2CO3-promoted aryl migration process.
abstract: A new domino strategy for the synthesis of highly functionalized quaternary imidazole derivatives via [3 + 2] heterocyclization, involving aryl migration and ring-opening of oxirane, has been developed. This domino reaction enables the successful assembly of three new sigma bonds including two C-N bonds in a simple operation. Features of this strategy include the mild conditions, convenient operation, and short reaction periods (15-20 min).
authors: School of Chemistry and Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, 211116, P. R. China.
authors: Hai-Wei
authors: HW
authors: Xu
authors: Wei
authors: W
authors: Fan
authors: Meng-Yuan
authors: MY
authors: Li
authors: Bo
authors: B
authors: Jiang
authors: Shu-Liang
authors: SL
authors: Wang
authors: Shu-Jiang
authors: SJ
authors: Tu
mesh_terms: D003500:Cyclization; D005027:Ethylene Oxide / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D007093:Imidazoles; D005027:Ethylene Oxide