title: The difference in clinic-pathological features between signet ring cell carcinoma and gastric mucinous adenocarcinoma.
abstract: We investigated the clinical and pathological features as well as the prognosis of signet ring cell carcinoma (SRC) and gastric mucinous carcinoma (GMC) to lay a foundation for the management of these two diseases. Two thousand four hundred thirty gastric cancer patients, including 288 SRCs and 80 GMCs who had received a gastrectomy between 1997 and 2007, were retrospectively evaluated. There were significant differences in tumor location, distant metastasis status, lymph node dissection, depth of invasion, Borrmann type, pTNM stage, and pathological lymph node status between SRCs and GMC (P = 0.001, 0.003, 0.01, 0.0002, 0.0013, 0.0001, and 0.265, respectively). After prognostic analysis, the cases with GMC received a relatively low 5-year specific survival rate compared to SRC (58.68 % vs. 66.25 %; P = 0.064). After Cox regression analysis, gender, age, lymph node metastatic ratio, pTNM stage, curative operation, and distant metastasis were identified as the independent prognostic factors in SRC. On the other hand, pTNM stage and distant metastasis were identified as the independent prognostic factors in GMC. In conclusion, the clinical and pathological features as well as prognosis of GMC and gastric SRC differed. Therefore, the treatment of the two diseases should be individualized.
authors: Department of Gastrointestinal Surgery, the Third Affiliated Hospital of Harbin Medical University, Harbin, China, 150040.
authors: Hao
authors: H
authors: Jiang
authors: Hongfeng
authors: H
authors: Zhang
authors: Lantian
authors: L
authors: Tian
authors: Xi
authors: X
authors: Zhang
authors: Yingwei
authors: Y
authors: Xue
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D000328:Adult; D018279:Carcinoma, Signet Ring Cell / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
references: BMC Cancer. 2010 Jun 20;10:308
references: 20565910
references: Tumour Biol. 2013 Jun;34(3):1485-91
references: 23404404
references: Gastric Cancer. 2001;4(2):83-6
references: 11706765
references: Tumour Biol. 1994;15(5):263-8
references: 7991986
references: J Surg Oncol. 1998 Apr;67(4):216-20
references: 9579367
references: BMC Cancer. 2007 Oct 24;7:200
references: 17958880
references: Dig Dis Sci. 2011 Jun;56(6):1749-56
references: 21104129
references: Gastric Cancer. 1998 Dec;1(1):10-24
references: 11957040
references: Surg Oncol. 2008 Dec;17(4):317-22
references: 18586486
references: Hepatogastroenterology. 2008 Mar-Apr;55(82-83):791-4
references: 18613456
references: Hepatogastroenterology. 2009 Jul-Aug;56(93):1227-31
references: 19760976
references: Br J Surg. 2004 Oct;91(10):1319-24
references: 15376179