title: The interplay between genome organization and nuclear architecture of primate evolutionary neo-centromeres.
abstract: An Evolutionary Neo-Centromere (ENC) is a centromere that emerged in an ectopic region of a chromosome during evolution. It is thought that the old centromere must be inactivated because dicentric chromosomes are not viable. The aim of the present study was to investigate whether 3D arrangement in the interphase nucleus of the novel and old centromeric domains was affected by the repositioning event. The data we present here strongly indicate that the ENC phenomenon does not affect the 3D location of either novel or old centromeres. Very likely, other features, such as gene density, rather than the newly acquired or lost functions, define positioning in the nucleus.
authors: Department of Biomedical Sciences, University of Modena and Reggio Emilia, via Campi 287, 41100 Modena, Italy; Department of Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy. Electronic address: mariana.lomiento@unimore.it.
authors: Mariana
authors: M
authors: Lomiento
authors: Florian
authors: F
authors: Grasser
authors: Mariano
authors: M
authors: Rocchi
authors: Stefan
authors: S
authors: Müller
mesh_terms: D000818:Animals; D053819:Atelinae / Q000235:genetics; D005075:Biological Evolution; D002460:Cell Line; D002467:Cell Nucleus / Q000235:genetics / Q000502:physiology; D002503:Centromere / Q000235:genetics* / Q000648:ultrastructure*; D002875:Chromosomes; D019143:Evolution, Molecular; D016678:Genome; D006071:Gorilla gorilla / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007399:Interphase / Q000235:genetics; D008254:Macaca nemestrina / Q000235:genetics; D010802:Phylogeny; D011148:Pongo pygmaeus / Q000235:genetics; D011323:Primates / Q000235:genetics*
keywords: 3D FISH; Evolutionary Neo-Centromere; Nuclear architecture