title: Pituitary adenoma with mucin cells in a man with an unusual presentation of Carney complex.
abstract: We describe a 44-year-old man with infertility, acromegaly, and hypergonadotropic hypogonadism. Clinical examination of the patient revealed hyperpigmented macules on the lips, buccal mucosa, and face which were histologically confirmed as cutaneous myxomas and blue nevi. Ultrasound revealed testicular calcifications and multiple hypoechoic thyroid nodules. MR imaging showed a pituitary microadenoma and resection revealed it to be a growth hormone and prolactin-secreting adenoma with the unusual finding of admixed individual mucin-producing cells. We discuss mucin cells in pituitary adenoma, an unreported pathologic finding in a patient with Carney complex.
authors: Departments of Pathology and Laboratory Medicine and Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Gabrielle_Yeaney@urmc.rochester.edu
authors: Gabrielle A
authors: GA
authors: Yeaney
authors: Jillene M
authors: JM
authors: Brathwaite
authors: Matthew L
authors: ML
authors: Dashnaw
authors: G Edward
authors: GE
authors: Vates
authors: Laura M
authors: LM
authors: Calvi
mesh_terms: D000015:Abnormalities, Multiple; D000236:Adenoma / Q000175:diagnosis* / Q000378:metabolism; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D056733:Carney Complex / Q000175:diagnosis* / Q000378:metabolism; D003937:Diagnosis, Differential; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D008297:Male; D009077:Mucins / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D009077:Mucins; D011388:Prolactin; D013006:Growth Hormone
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