title: Laser photodynamic treatment for in situ squamous cell carcinoma of the glans monitored by reflectance confocal microscopy.
abstract: While mutilating surgery can be avoided with non-surgical treatment of in situ squamous cell carcinoma (SCC) of the penis, such as photodynamic therapy (PDT), this procedure is not followed by histological evaluation to verify the total removal of the lesion, leading to possible recurrence. We present the first case of in situ penile SCC treated with laser PDT, where the efficacy of the treatment was monitored by reflectance confocal microscopy (RCM) using a handheld camera. In the future RCM may be regarded as a complementary technique to assess the efficacy of non-surgical treatment of mucous membrane cancers.
authors: Department of Dermatology, University Hôpital of Saint Etienne, Saint Etienne, France.
authors: Elisa
authors: E
authors: Cinotti
authors: Jean Luc
authors: JL
authors: Perrot
authors: Bruno
authors: B
authors: Labeille
authors: Catherine
authors: C
authors: Douchet
authors: Nicolas
authors: N
authors: Mottet
authors: Frédéric
authors: F
authors: Cambazard
mesh_terms: D000368:Aged; D000622:Aminolevulinic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000188:drug therapy* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D053685:Laser Therapy; D008297:Male; D018613:Microscopy, Confocal; D010412:Penile Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid
keywords: confocal microscopy; glans; in situ squamous cell carcinoma; laser; methyl aminolevulinate; mucosal cancer; penis; photodynamic therapy