title: Descriptive epidemiology of ependymal tumours in the United States.
abstract: BACKGROUND
  Ependymomas are rare primary gliomas that commonly affect both children and adults, but unique as survival is worse in children.
  
  
  METHODS
  Data on brain and central nervous system primary malignant and non-malignant ependymal tumours from the Central Brain Tumor Registry of the United States analytic data set and primary malignant ependymal tumours from the SEER 13 registries research data file were used to evaluate incidence and survival, respectively.
  
  
  RESULTS
  The 2004-2009 average annual age-adjusted incidence rate of ependymal tumours was 0.41/100,000. Spinal cord/cauda equina was the primary site at diagnosis for 50-60% of ependymal tumours in adult age groups in contrast to about 20% in children and adolescents. Ependymoma was the most frequent histology in all age groups; however, anaplastic ependymoma comprised about 30% in cases 0-19 years of age compared with about 3-5% in adult age groups. Overall, relative survival was favourable with rates at ∼85% and 75% at 3 and 10 years post diagnosis, respectively. However, children and adolescents, the oldest adult age group, cases diagnosed with anaplastic ependymoma and/or tumour location in a brain site had lowest survival rates.
  
  
  CONCLUSIONS
  Paediatric cases had worse outcomes compared with adults for numerous reasons including having a higher percentage of anaplastic ependymomas and greater percentage of cases of intracranial disease.
authors: Departments of Medicine and Neurology, Division of Oncology, University of Kentucky, Lexington, KY, USA. jlvillano@uky.edu
authors: J L
authors: JL
authors: Villano
authors: C K
authors: CK
authors: Parker
authors: T A
authors: TA
authors: Dolecek
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000401:mortality; D016543:Central Nervous System Neoplasms / Q000453:epidemiology* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D004806:Ependymoma / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012042:Registries; D015996:Survival Rate; D014481:United States / Q000453:epidemiology; D055815:Young Adult
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