title: Short-term alcohol consumption may have detrimental effect on fibrinolysis and endothelial function: preliminary report of prospective randomised study.
abstract: OBJECTIVE
  This study was designed to clarify the impact of the short-term consumption of different types of alcoholic beverages on haemostatic factors, C-reactive protein (hsCRP) and endothelin-1 (E-1) plasma levels.
  
  
  METHODS
  The study group consisted of 57 healthy male volunteers, aged 20-29 years. Subjects were randomised to consume 300 mL of red wine, white wine, 12% ethanol, black currant juice or water for five days. Blood samples were collected for CRP, tissue type plasminogen activator antigen (t-PA:Ag), plasminogen activator inhibitor antigen (PAI-1:Ag) and E-1 at baseline, on day 2, and on day 6.
  
  
  RESULTS
  A significant increase in PAI-1:Ag concentration was observed in the red wine drinking group (day 1: 44.98; day 2:56.86; day 6: 47.44 ng/mL; p = 0.05). A similar increase of E-1 level was found in the 12% ethanol group (day 1: 0.53; day 2:1.65; day 6: 1.11 fmol/mL; p = 0.01). Dividing the whole study group according to ethanol content of consumed beverages revealed significant changes in tPA:Ag, PAI-1:Ag and E-1 levels. In the alcohol drinking group, significant increases of PAI-1:Ag (day 1: 44.75; day 2: 54.07; day 6: 44.80 ng/mL; p < 0.05); tPA:Ag level (day 1: 3.65; day 2: 4.17; day 6: 5.03 ng/mL;p < 0.02) and E-1 (day 1: 0.42; day 2: 1.01; day 6: 0.97 fmol/mL; p < 0.002) were observed.
  
  
  CONCLUSIONS
  Short-term alcohol consumption increases tPA:Ag, PAI:Ag and E-1 plasma levels. This effect may have an unfavourable impact on the fibrinolytic system and endothelial function.
authors: 2nd Cardiology Clinic, University Hospital No. 2 in Bydgoszcz, Collegium Medicum, Nicolaus Copernicus University, Torun, Poland. joannna@op.pl.
authors: Joanna
authors: J
authors: Banach
authors: Ewa
authors: E
authors: Żekanowska
authors: Robert
authors: R
authors: Bujak
authors: Wojciech
authors: W
authors: Gilewski
authors: Jan
authors: J
authors: Błażejewski
authors: Danuta
authors: D
authors: Karasek
authors: Wojciech
authors: W
authors: Balak
authors: Jaroslaw
authors: J
authors: Pietrzak
authors: Wladyslaw
authors: W
authors: Sinkiewicz
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D019332:Endothelin-1 / Q000097:blood*; D000431:Ethanol / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011446:Prospective Studies; D014920:Wine; D055815:Young Adult
chemical_list: D019332:Endothelin-1; D017395:Plasminogen Activator Inhibitor 1; D000431:Ethanol; D002097:C-Reactive Protein