title: OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis.
abstract: The OPRM1 gene encodes the µ-opioid receptor, which is the primary site of action of most opioids. Several studies and three meta-analyses have examined a possible link between the exonic OPRM1 A118G (rs1799971) polymorphism and opioid dependence; however, results have been inconclusive. Therefore, a systematic review and meta-analysis have been carried out to examine whether this polymorphism is associated with opioid dependence. Thirteen studies (n = 9385), comprising 4601 opioid dependents and 4784 controls, which evaluated association of the OPRM1 rs1799971 polymorphism with susceptibility to opioids, were included in this study. Our meta-analysis showed significant association between this polymorphism and susceptibility to opioid dependence in overall studies under a codominant model, as well as susceptibility to opioid dependence or heroin dependence in Asians under an autosomal dominant model. The nonsynonymous OPRM1 rs1799971 might be a risk factor for addiction to opioids or heroin in an Asian population.
authors: Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. batoolsadat@yahoo.com
authors: Batoul Sadat
authors: BS
authors: Haerian
authors: Monir Sadat
authors: MS
authors: Haerian
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects; D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006556:Heroin Dependence / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D017450:Receptors, Opioid, mu / Q000235:genetics*; D012307:Risk Factors
chemical_list: D000701:Analgesics, Opioid; C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu