title: Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2.
abstract: In the past decade, we have observed exciting advances in lung cancer therapy, including the development of targeted therapies. However, additional strategies for early detection and tumor-based therapy are still essential in improving patient outcomes. EGF receptor (EGFR) and MET (the receptor tyrosine kinase for hepatocyte growth factors) are cell-surface tyrosine kinase receptors that have been implicated in diverse cellular processes and as regulators of several microRNAs (miRNAs), thus contributing to tumor progression. Here, we demonstrate a biological link between EGFR, MET, and the miRNA cluster 23a ~ 27a ~ 24-2. We show that miR-27a regulates MET, EGFR, and Sprouty2 in lung cancer. In addition, we identify both direct and indirect mechanisms by which miR-27a can regulate both MET and EGFR. Thus, we propose a mechanism for MET and EGFR axis regulation that may lead to the development of therapeutics in lung cancer.
authors: Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
authors: Mario
authors: M
authors: Acunzo
authors: Giulia
authors: G
authors: Romano
authors: Dario
authors: D
authors: Palmieri
authors: Alessandro
authors: A
authors: Laganá
authors: Michela
authors: M
authors: Garofalo
authors: Veronica
authors: V
authors: Balatti
authors: Alessandra
authors: A
authors: Drusco
authors: Mario
authors: M
authors: Chiariello
authors: Patrick
authors: P
authors: Nana-Sinkam
authors: Carlo M
authors: CM
authors: Croce
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D066246:ErbB Receptors / Q000096:biosynthesis* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000096:biosynthesis* / Q000235:genetics; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008565:Membrane Proteins; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D019859:Proto-Oncogene Proteins c-met / Q000096:biosynthesis* / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C531388:MIRN27 microRNA, human; D008565:Membrane Proteins; D035683:MicroRNAs; D012334:RNA, Neoplasm; C485561:SPRY2 protein, human; C512478:EGFR protein, human; D066246:ErbB Receptors; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met
keywords: cell signaling; epigenetics
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