title: Two new highly oxygenated and rearranged limonoids from Phyllanthus cochinchinensis.
abstract: A new 6/6/5/6-fused limonoid, phyllanthoid A (1), possessing both 19/30 and 19/29 oxygen bridges was isolated from Phyllanthus cochinchinensis (Euphorbiaceae), together with a new related limonoid, phyllanthoid B (2). Their structures were determined by spectroscopic analysis and single-crystal X-ray diffraction in the case of 1. Compound 1 displayed moderate antifeedant against the generalist plant-feeding insect Spodoptera exigua and cytotoxicity against the MCF-7 cell line.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences, Kunming 650201, Yunnan, P. R. China, and University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
authors: Jian-Qiang
authors: JQ
authors: Zhao
authors: Yan-Ming
authors: YM
authors: Wang
authors: Hong-Ping
authors: HP
authors: He
authors: Sheng-Hong
authors: SH
authors: Li
authors: Xiao-Nian
authors: XN
authors: Li
authors: Chong-Ren
authors: CR
authors: Yang
authors: Dong
authors: D
authors: Wang
authors: Hong-Tao
authors: HT
authors: Zhu
authors: Min
authors: M
authors: Xu
authors: Ying-Jun
authors: YJ
authors: Zhang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D005247:Feeding Behavior / Q000187:drug effects*; D006801:Humans; D007814:Larva; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D029803:Phyllanthus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D036701:Limonins; D010936:Plant Extracts; C000588529:phyllanthoid A; C000588530:phyllanthoid B