title: Oenothein B suppresses lipopolysaccharide (LPS)-induced inflammation in the mouse brain.
abstract: Oenothein B has been recently evaluated for its ability to affect inflammatory responses in peripheral tissues. In this study, we examined its effect on the damage to the central nervous system due to systemic inflammation. For this purpose, ICR mice were injected with an intraperitoneal (i.p.) dose of lipopolysaccharide (LPS; 1 mg/kg mouse). When oenothein B was administered per os (p.o.), it suppressed (1) LPS-induced abnormal behavior in open field; (2) LPS-induced microglial activation in the hippocampus and striatum; and (3) LPS-induced cyclooxygenase (COX)-2 production in the hippocampus and striatum of these mice. These results suggest that oenothein B had the ability to reduce neuroinflammation in the brain during systemic inflammation.
authors: Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. furukawa@cc.matsuyama-u.ac.jp.
authors: Satoshi
authors: S
authors: Okuyama
authors: Nahomi
authors: N
authors: Makihata
authors: Morio
authors: M
authors: Yoshimura
authors: Yoshiaki
authors: Y
authors: Amakura
authors: Takashi
authors: T
authors: Yoshida
authors: Mitsunari
authors: M
authors: Nakajima
authors: Yoshiko
authors: Y
authors: Furukawa
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000276:immunology; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D053583:Interleukin-1beta / Q000235:genetics; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D051379:Mice; D017628:Microglia / Q000187:drug effects / Q000276:immunology; D029594:Onagraceae / Q000737:chemistry; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics
chemical_list: D000893:Anti-Inflammatory Agents; D047348:Hydrolyzable Tannins; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D012333:RNA, Messenger; C080077:oenothein B; D051546:Cyclooxygenase 2
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