title: Synthesis and evaluation of anti-inflammatory and analgesic activities of new 1,2,4-triazole derivatives.
abstract: In this study, the synthesis, anti-inflammatory and analgesic activities of eight new 5-thioalkyl-1,3-diaryl-1,2,4- triazole derivatives were reported. For the anti-inflammatory study, the carrageenan-induced rat paw edema model was used. The test compounds in 50 mg/kg and 100 mg/kg were injected as IP and paw edema was determined. The results showed that some of the compounds have good activity compared to the references drug, indomethacin. For analgesic activity, the test compounds were studied using the in Tail-flick test model in 50 and 100 mg/kg as IP injections. Their analgesic activities were determined after 30 min via latency time assay. Statistical analysis showed that all test compounds have antinociceptive activity in the range of 24% -47% as compared to the control with a dose of 50 mg/kg. However, all tested compounds have analgesic activity lower than the standard drug, morphine.
authors: Fatemeh
authors: F
authors: Ahmadi
authors: Mohsen Rezayan
authors: MR
authors: Ghayahbashi
authors: Mohammad
authors: M
authors: Sharifzadeh
authors: Eskandar
authors: E
authors: Alipoiur
authors: Seyed Nasser
authors: SN
authors: Ostad
authors: Mohsen
authors: M
authors: Vosooghi
authors: Hamid Reza
authors: HR
authors: khademi
authors: Mohsen
authors: M
authors: Amini
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D006614:Hindlimb; D007213:Indomethacin / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D014230:Triazoles; D009020:Morphine; D002351:Carrageenan; D007213:Indomethacin