title: Association of obesity with cardiovascular disease mortality in the PLCO trial.
abstract: OBJECTIVE
  Obesity is a risk factor for cardiovascular disease (CVD) mortality, but the association between obesity and specific causes of CVD mortality is still under investigation.
  
  
  METHODS
  We prospectively examined body-mass index (BMI) in relation to CVD-specific causes of death in approximately 86,000 US men and women in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, followed for up to 13 years. BMI was calculated from self-reported weight and height at baseline. Hazard ratios (HRs) were calculated overall and stratified by sex, smoking status, and educational level.
  
  
  RESULTS
  Overweight non-obese participants (BMI: 25.0-29.9) were not at excess risk for CVD mortality (HR and CIs are 1.02 [0.92-1.13]), compared to participants of normal BMI (18.5-24.9). Excess CVD mortality was observed for participants of BMI 30.0-34.9 (HR and CIs: 1.29 [1.13-1.48]), BMI 35.0-39.9 (HR and CIs: 1.87 [1.51-2.32]) and BMI 40.0+ (HR and CIs: 2.21 [1.57-3.21]) (p<0.001 for trend). BMI was unrelated to mortality due to stroke. The observed association of BMI with CVD was independent of gender, smoking status and educational level.
  
  
  CONCLUSIONS
  Obesity is associated with increased mortality due to CVD.
authors: Division of Epidemiology, Department of Population Health, New York University School of Medicine, 650 First Ave, New York, NY 10016, USA.
authors: Jieying
authors: J
authors: Jiang
authors: Jiyoung
authors: J
authors: Ahn
authors: Wen-Yi
authors: WY
authors: Huang
authors: Richard B
authors: RB
authors: Hayes
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000401:mortality*; D004522:Educational Status; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D057566:Self Report; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology
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