title: 22q11.2 deletion syndrome with life-threatening adenovirus infection.
abstract: Adenovirus causes significant morbidity and mortality in immunocompromised children. We report how an infusion of HLA-matched sibling donor T lymphocytes rapidly eradicated life-threatening, high-level adenoviremia in a child with complete DiGeorge syndrome (22q11.2 deletion) who went on to reconstitute a diverse, donor-derived, postthymic T-cell repertoire.
authors: Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom. w.ip@ucl.ac.uk
authors: Winnie
authors: W
authors: Ip
authors: Hong
authors: H
authors: Zhan
authors: Kimberly C
authors: KC
authors: Gilmour
authors: E Graham
authors: EG
authors: Davies
authors: Waseem
authors: W
authors: Qasim
mesh_terms: D000258:Adenovirus Infections, Human / Q000175:diagnosis / Q000276:immunology / Q000601:surgery*; D016026:Bone Marrow Transplantation; D004062:DiGeorge Syndrome / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D013601:T-Lymphocytes / Q000637:transplantation*
keywords: ADV; Adenovirus; Complete DiGeorge syndrome; HCT; Hematopoietic cell transplantation; T-cell receptor rearrangement excision circles; TRECs; cDGS