title: ALDH7A1 expression is associated with recurrence in patients with surgically resected non-small-cell lung carcinoma.
abstract: OBJECTIVE
  The purpose of this study was to describe the prognostic significance of ALDH7A1 in surgically treated non-small-cell lung carcinoma. (NSCLC).
  
  
  METHODS
  We immunohistochemically analyzed ALDH7A1 expression in surgically resected NSCLC from 89 patients using a tissue microarray.
  
  
  RESULTS
  ALDH7A1 staining was positive in 43 patients and negative in 44 patients, with two tumor sections missing. For stage I NSCLC patients, ALDH7A1 positivity was associated with decreased recurrence-free and overall survival. Multivariate analysis demonstrated that ALDH7A1-expressing NSCLC tumors had a significantly higher incidence of lung cancer recurrence compared with patients with ALDH7A1-negative tumors, although there was no association with overall survival.
  
  
  CONCLUSIONS
  For patients with NSCLC, low ALDH7A1 expression was associated with a decreased incidence of cancer recurrence. Specifically in stage I patients, negative staining for ALDH7A1 was associated with improved recurrence-free and overall survival, suggesting a predictive role in surgically treated patients.
authors: Department of Radiation Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.
authors: Nicholas J
authors: NJ
authors: Giacalone
authors: Robert B
authors: RB
authors: Den
authors: Rosana
authors: R
authors: Eisenberg
authors: Heidi
authors: H
authors: Chen
authors: Sandra J
authors: SJ
authors: Olson
authors: Pierre P
authors: PP
authors: Massion
authors: David P
authors: DP
authors: Carbone
authors: Bo
authors: B
authors: Lu
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000096:biosynthesis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: C089507:ALDH7A1 protein, human; D000444:Aldehyde Dehydrogenase
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