title: Gap junction remodeling in skin repair following wounding and disease.
abstract: In the present review, we provide an overview of connexin expression during skin development and remodeling in wound healing, and reflect on how loss- or gain-of-function connexin mutations may change cellular phenotypes and lead to diseases of the skin. We also consider the therapeutic value of targeting connexins in wound healing.
authors: Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada.
authors: Jared M
authors: JM
authors: Churko
authors: Dale W
authors: DW
authors: Laird
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D017630:Connexins / Q000235:genetics / Q000378:metabolism*; D017629:Gap Junctions / Q000378:metabolism* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D010641:Phenotype; D015398:Signal Transduction; D012867:Skin / Q000254:growth & development / Q000293:injuries / Q000378:metabolism* / Q000473:pathology; D012871:Skin Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014945:Wound Healing
chemical_list: D017630:Connexins