title: Imbalance between excitation and inhibition in the somatosensory cortex produces postadaptation facilitation.
abstract: Adaptation is typically associated with attenuation of the neuronal response during sustained or repetitive sensory stimulation, followed by a gradual recovery of the response to its baseline level thereafter. Here, we examined the process of recovery from sensory adaptation in layer IV cells of the rat barrel cortex using in vivo intracellular recordings. Surprisingly, in approximately one-third of the cells, the response to a test stimulus delivered a few hundred milliseconds after the adapting stimulation was significantly facilitated. Recordings under different holding potentials revealed that the enhanced response was the result of an imbalance between excitation and inhibition, where a faster recovery of excitation compared with inhibition facilitated the response. Hence, our data provide the first mechanistic explanation of sensory facilitation after adaptation and suggest that adaptation increases the sensitivity of cortical neurons to sensory stimulation by altering the balance between excitation and inhibition.
authors: Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
authors: Katayun
authors: K
authors: Cohen-Kashi Malina
authors: Muna
authors: M
authors: Jubran
authors: Yonatan
authors: Y
authors: Katz
authors: Ilan
authors: I
authors: Lampl
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000222:Adaptation, Physiological / Q000502:physiology*; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D005260:Female; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D018408:Patch-Clamp Techniques; D010812:Physical Stimulation; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*; D014738:Vibrissae / Q000294:innervation
references: Neuron. 2002 Apr 25;34(3):437-46
references: 11988174
references: Neuron. 2009 Mar 12;61(5):750-61
references: 19285471
references: Curr Opin Neurobiol. 2007 Aug;17(4):423-9
references: 17714934
references: Nat Neurosci. 2006 Apr;9(4):534-42
references: 16547512
references: J Neurophysiol. 2012 Jun;107(12):3370-84
references: 22423001
references: J Acoust Soc Am. 1993 Jan;93(1):418-24
references: 8423258
references: J Neurophysiol. 2002 Oct;88(4):1924-32
references: 12364518
references: J Neurosci. 2000 Oct 1;20(19):7455-62
references: 11007905
references: J Physiol. 2007 Dec 15;585(Pt 3):759-77
references: 17947318
references: Neuron. 2010 Apr 29;66(2):273-86
references: 20435003
references: Science. 1999 Aug 27;285(5432):1405-8
references: 10464100
references: PLoS Biol. 2006 May;4(5):e124
references: 16605304
references: J Neurophysiol. 2007 May;97(5):3155-64
references: 17344377
references: Rev Neurosci. 1999;10(3-4):181-200
references: 10526886
references: J Physiol. 2002 Mar 1;539(Pt 2):567-78
references: 11882688
references: PLoS Biol. 2007 Feb;5(2):e19
references: 17253902
references: Cereb Cortex. 2011 May;21(5):977-90
references: 20851851
references: J Neurosci. 2006 Dec 20;26(51):13363-72
references: 17182787
references: J Neurosci. 2011 Oct 19;31(42):15016-25
references: 22016535
references: J Neurosci. 2010 Apr 7;30(14):5071-7
references: 20371827
references: Eur J Neurosci. 2012 Mar;35(6):826-37
references: 22384999
references: Nat Neurosci. 2002 Sep;5(9):883-91
references: 12161755
references: Nature. 2001 Aug 23;412(6849):787-92
references: 11518957
references: Vis Neurosci. 1991 Mar;6(3):239-55
references: 2054326
references: J Neurosci. 1997 Oct 15;17(20):7926-40
references: 9315911
references: J Physiol. 2002 Aug 15;543(Pt 1):49-70
references: 12181281
references: Science. 2006 Jun 16;312(5780):1622-7
references: 16778049
references: J Neurophysiol. 2003 Sep;90(3):1379-91
references: 12750410
references: Biol Cybern. 2012 Dec;106(11-12):657-68
references: 22711216
references: J Neurosci. 2002 Oct 1;22(19):8720-5
references: 12351747
references: J Pharmacol Exp Ther. 1982 Mar;220(3):476-81
references: 6278125
references: J Neurosci. 1990 Aug;10(8):2638-48
references: 2388081
references: J Neurosci. 2012 Jan 18;32(3):983-8
references: 22262896
references: Nature. 2000 Jul 20;406(6793):302-6
references: 10917531
references: J Acoust Soc Am. 1994 Aug;96(2 Pt 1):771-80
references: 7930078
references: J Neurophysiol. 2005 Mar;93(3):1450-67
references: 15496491
references: Vision Res. 1991;31(2):223-36
references: 2017883
references: Nat Neurosci. 2008 Nov;11(11):1335-42
references: 18931665
references: J Neurosci. 1991 Feb;11(2):344-56
references: 1992005
references: Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5323-8
references: 9560274
references: Brain Res. 2006 Aug 2;1102(1):109-16
references: 16806126
references: Nat Neurosci. 2003 Apr;6(4):391-8
references: 12652303
references: Exp Brain Res. 1995;106(3):434-48
references: 8983987
references: J Physiol. 2002 Feb 1;538(Pt 3):803-22
references: 11826166
references: J Neurophysiol. 2004 Dec;92(6):3244-54
references: 15306632
references: Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):719-23
references: 9012851
references: J Neurophysiol. 2001 Jul;86(1):354-67
references: 11431516
references: Neuron. 2005 Oct 20;48(2):315-27
references: 16242411
references: J Neurophysiol. 1999 Mar;81(3):1171-83
references: 10085344
references: Neuron. 2007 Oct 25;56(2):339-55
references: 17964250
references: J Neurophysiol. 2006 May;95(5):2923-32
references: 16467421
references: J Neurophysiol. 2008 Jul;100(1):317-26
references: 18436628
references: Neuroscience. 2003;117(3):769-78
references: 12617980
references: Neuron. 1999 Jun;23(2):385-97
references: 10399943
references: Neuron. 1997 Sep;19(3):679-86
references: 9331357
references: J Neurophysiol. 2002 Jun;87(6):2904-14
references: 12037194
references: Nat Neurosci. 2010 Dec;13(12):1534-41
references: 21102447
references: J Neurosci. 2008 Dec 3;28(49):13320-30
references: 19052224