title: Postoperative radiotherapy for uterine cervical cancer: impact of lymph node and histological type on survival.
abstract: OBJECTIVE
  To retrospectively analyze the treatment results of postoperative radiotherapy (PORT) in patients with early-stage uterine cervical cancer.
  
  
  METHODS
  Records of 141 patients with stage IB-IIB uterine cervical cancer treated with PORT from 1985 to 2004 were retrospectively reviewed. The majority of patients received whole-pelvic radiotherapy with antero-posterior fields, and the total radiation doses ranged from 10.8-60 Gy (median: 50.4 Gy). The median follow-up of all 141 patients was 106 months (range: 0.8-273.7 months).
  
  
  RESULTS
  Multivariate analysis revealed that positive lymph node status (p=0.001) and histological type (p=0.015) were independent prognostic factors for overall survival. The group with three or more involved lymph nodes was significantly more likely to have extra-pelvic recurrence when compared with the groups with no (p=0.006) and up to two lymph nodes (p=0.024), respectively.
  
  
  CONCLUSIONS
  PORT yielded excellent pelvic control rates for early-stage uterine cervical cancer. Lymph node status and histological type were significant prognostic factors for overall survival of patients with these tumors.
authors: Department of Radiology, Graduate School of Medical Science University of the Ryukyus School of Medicine, 207 Uehara, Nishihara-cho, Okinawa, 903-0215, Japan. gokasuya@gmail.com
authors: Goro
authors: G
authors: Kasuya
authors: Kazuhiko
authors: K
authors: Ogawa
authors: Shiro
authors: S
authors: Iraha
authors: Yutaka
authors: Y
authors: Nagai
authors: Makoto
authors: M
authors: Hirakawa
authors: Takafumi
authors: T
authors: Toita
authors: Yasumasa
authors: Y
authors: Kakinohana
authors: Wataru
authors: W
authors: Kudaka
authors: Morihiko
authors: M
authors: Inamine
authors: Takuro
authors: T
authors: Ariga
authors: Yoichi
authors: Y
authors: Aoki
authors: Sadayuki
authors: S
authors: Murayama
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D009367:Neoplasm Staging; D010386:Pelvic Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D011184:Postoperative Period; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D055815:Young Adult
keywords: Radiation therapy; postoperative radiotherapy; uterine cervical cancer