title: Viral tracing identifies parallel disynaptic pathways to the hippocampus.
abstract: Electrophysiological and lesion studies in rodents have shown that the dorsal (septal) and ventral (temporal) segments of the hippocampus have functional specializations that can be understood in terms of their anatomical connections with distinct brain areas. Here we explore the circuitry associated with the hippocampus using the pseudorabies virus-Bartha strain (PRV-Bartha) tracer in the rat to examine both direct (first-order) and indirect (second-order) projections to the hippocampus. Based on analysis of PRV-Bartha infection density, we demonstrate two parallel pathways from the limbic cortex to the hippocampus. A dorsal "spatial cognition" pathway provides disynaptic input from the retrosplenial, anterior cingulate, and orbital cortex to the dorsal hippocampus, with potential synaptic relays in the anterior thalamic nuclei and dorsolateral entorhinal cortex. A ventral "executive control" pathway provides disynaptic input from the prelimbic, infralimbic, and orbital cortex to the ventral hippocampus, with potential synaptic relays in the midline thalamic nuclei and the rostral caudomedial entorhinal cortex. These data suggest a new anatomical framework for understanding the functional interactions between the cortex and hippocampus, especially in cognitive disorders that involve both structures, such as frontotemporal dementia.
authors: Department of Psychology, McGill University, Montreal, Quebec H3A 1B1, Canada.
authors: Judy A
authors: JA
authors: Prasad
authors: Yogita
authors: Y
authors: Chudasama
mesh_terms: D000818:Animals; D007839:Functional Laterality; D011558:Herpesvirus 1, Suid / Q000378:metabolism; D006624:Hippocampus / Q000502:physiology* / Q000821:virology; D008297:Male; D009434:Neural Pathways / Q000502:physiology* / Q000821:virology; D017397:Prefrontal Cortex / Q000502:physiology* / Q000821:virology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013569:Synapses / Q000502:physiology*; D013997:Time Factors; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D014764:Viral Proteins
references: Nat Rev Neurosci. 2011 Sep 07;12(10):585-601
references: 21897434
references: Neuroscience. 1991;42(1):73-102
references: 1713657
references: J Comp Neurol. 1998 Aug 24;398(2):179-205
references: 9700566
references: Eur J Neurosci. 2004 Jun;19(12):3291-304
references: 15217385
references: Brain Res Rev. 2007 Nov;56(1):1-26
references: 17559940
references: Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15235-9
references: 20696892
references: J Neurosci. 1995 Jan;15(1 Pt 2):709-20
references: 7823174
references: J Neurosci. 1995 Jan;15(1 Pt 1):70-86
references: 7823153
references: Hippocampus. 1997;7(4):397-402
references: 9287079
references: Curr Opin Neurobiol. 1993 Apr;3(2):225-9
references: 8390320
references: J Comp Neurol. 2006 Dec 10;499(5):768-96
references: 17048232
references: J Comp Neurol. 1982 Jul 20;209(1):69-78
references: 7119174
references: J Comp Neurol. 1989 Dec 8;290(2):213-42
references: 2592611
references: J Neurosci. 1999 Dec 15;19(24):11049-60
references: 10594085
references: Neurosci Biobehav Rev. 2003 Oct;27(6):555-79
references: 14599436
references: J Comp Neurol. 1984 Apr 10;224(3):371-85
references: 6715585
references: Scand J Psychol. 2001 Jul;42(3):225-38
references: 11501737
references: Neuron. 2010 Jan 14;65(1):7-19
references: 20152109
references: J Neurosci. 1993 Jun;13(6):2515-39
references: 8388923
references: J Comp Neurol. 1977 Mar 1;172(1):49-84
references: 65364
references: J Comp Neurol. 1988 Apr 22;270(4):506-16
references: 2836479
references: J Comp Neurol. 1996 Jan 22;364(4):637-50
references: 8821451
references: J Comp Neurol. 1998 Aug 17;398(1):49-82
references: 9703027
references: Eur J Neurosci. 2009 Aug;30(3):472-84
references: 19656177
references: Neuron. 2010 Oct 6;68(1):127-37
references: 20920796
references: Cereb Cortex. 2009 Jan;19(1):72-8
references: 18403396
references: Behav Brain Res. 2003 Nov 30;146(1-2):105-19
references: 14643464
references: J Neurosci. 2012 Aug 8;32(32):10915-24
references: 22875926
references: Eur J Neurosci. 2009 Dec;30(12):2327-37
references: 20092575
references: Neuropsychopharmacology. 2011 Jan;36(2):529-38
references: 20962768
references: Nature. 2005 Aug 11;436(7052):801-6
references: 15965463
references: Eur J Neurosci. 2006 Apr;23(8):2185-96
references: 16630065
references: J Comp Neurol. 1990 Jun 8;296(2):179-203
references: 2358531
references: Brain Struct Funct. 2013 Jan;218(1):85-96
references: 22270811
references: Neuroscience. 1989;31(3):571-91
references: 2687721
references: Hippocampus. 2008;18(3):251-7
references: 18064705
references: Cereb Cortex. 2013 Jun;23(6):1396-409
references: 22615141
references: Brain Res. 1999 Aug 14;838(1-2):171-83
references: 10446330
references: Neuroscience. 2006 Sep 29;142(1):1-20
references: 16887277
references: Neurosci Lett. 1995 Dec 1;201(1):84-6
references: 8830320
references: Neurosci Biobehav Rev. 2012 Aug;36(7):1579-96
references: 21964564
references: Hippocampus. 1992 Jan;2(1):1-11
references: 1308170
references: Brain Res. 1981 Jul 27;217(1):150-4
references: 7260612
references: J Comp Neurol. 1998 Aug 17;398(1):25-48
references: 9703026
references: Exp Brain Res. 1984;54(3):499-512
references: 6723868
references: Prog Neurobiol. 1989;33(3):161-253
references: 2682783
references: Behav Neurosci. 2001 Aug;115(4):841-9
references: 11508723
references: J Comp Neurol. 2004 Dec 6;480(2):115-42
references: 15514932
references: Trends Neurosci. 1994 Feb;17(2):52-7
references: 7512768
references: J Comp Neurol. 1985 Dec 1;242(1):40-55
references: 4078047
references: Behav Neurosci. 2002 Feb;116(1):85-94
references: 11895186
references: Exp Brain Res. 1994;101(1):8-23
references: 7843305
references: J Neurosci. 1997 Mar 15;17(6):2143-67
references: 9045740
references: Curr Opin Neurobiol. 2007 Aug;17(4):417-22
references: 17707635
references: J Comp Neurol. 1991 Nov 22;313(4):574-86
references: 1783682
references: Microbiol Mol Biol Rev. 2005 Sep;69(3):462-500
references: 16148307
references: Brain Struct Funct. 2007 Sep;212(2):149-79
references: 17717690
references: J Neurosci. 1997 Mar 1;17(5):1880-90
references: 9030646
references: J Comp Neurol. 2003 Aug 25;463(3):249-63
references: 12820159
references: Hippocampus. 2012 Apr;22(4):680-92
references: 21538656
references: Brain Struct Funct. 2009 Feb;213(3):329-42
references: 19132385
references: Brain Res. 1990 Oct 8;529(1-2):165-77
references: 1704281
references: Eur J Neurosci. 2010 Jun;31(12):2292-307
references: 20550571
references: Eur J Neurosci. 2013 Feb;37(4):640-7
references: 23190048
references: J Neurosci. 2001 Sep 15;21(18):7323-30
references: 11549742
references: Ann N Y Acad Sci. 2000 Jun;911:1-24
references: 10911864
references: Behav Neurosci. 1999 Dec;113(6):1170-88
references: 10636297
references: PLoS Biol. 2009 Apr 21;7(4):e1000089
references: 19385719