title: Galectin-9 in tumor biology: a jack of multiple trades.
abstract: Galectin family members have been shown to exert multiple roles in the context of tumor biology. Several recent findings support a similar multi-faceted role for galectin-9. Galectin-9 expression is frequently altered in cancer as compared to normal tissues. In addition, an increasing amount of evidence suggests that galectin-9 is involved in several aspects of tumor progression, including tumor cell adhesion and survival, immune escape and angiogenesis. Also, galectin-9 shows potential as a prognostic marker and a therapeutic target for several malignancies. In this review we summarize both the established and the emerging roles of galectin-9 in tumor biology and discuss the potential application of galectin-9 in anti-cancer therapy.
authors: Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
authors: Roy
authors: R
authors: Heusschen
authors: Arjan W
authors: AW
authors: Griffioen
authors: Victor L
authors: VL
authors: Thijssen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D037161:Galectins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D017386:Sequence Homology, Amino Acid
chemical_list: D000970:Antineoplastic Agents; D037161:Galectins; C105032:LGALS9 protein, human; C508186:galectin 9, mouse