title: A new bioactive aminophenoxazinone alkaloid from a marine-derived actinomycete.
abstract: Chemical investigation of the marine Streptomyces sp. Eg25 led to the isolation of one new natural 2-aminophenoxazin-3-one-8-carboxylic acid methyl ester named maroxazinone (1) as well as the known compounds elloxazinone A (2), exfoliazone (3), carboxyexfoliazone (4), elloxazinone B (5) and venezueline D (6). The chemical structures of the isolated compounds were deduced from extensive studies of NMR ((1)H and (13)C NMR, (1)H-(1)H COSY, HMQC and HMBC) and mass spectra. The cytotoxic activities of the new maroxazinone (1) and venezueline D (6) against breast carcinoma cell line (MCF7), liver carcinoma cell line (HEPG2) and colon carcinoma cell line (HCT116) were investigated.
authors: a Chemistry Department , Faculty of Science, Helwan University , Ain Helwan, Cairo , Egypt.
authors: Mohamed S
authors: MS
authors: Abdelfattah
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D010078:Oxazines / Q000737:chemistry / Q000302:isolation & purification*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D010078:Oxazines; C521436:elloxazinone A; C521437:elloxazinone B; C000590664:maroxazinone; C067081:exfoliazone