title: Live birth in a woman without ovaries after autograft of frozen-thawed ovarian tissue combined with growth factors.
abstract: Currently, cryopreservation of oocytes, embryos and ovarian tissue is considered the basis of fertility preservation programs for women with cancer and other diseases who are rendered sterile by gonadotoxic drugs or radiation.Numerous studies have confirmed that autograft of frozen-thawed ovarian tissue can restore ovarian function and fertility. A total of twenty-two live births have been reported but we still have to consider this technique as experimental. The main problem is that the implant undergoes ischemia until neoangiogenesis is restored, resulting in significant follicular loss.At the moment, there are numerous publications in different medical fields that publish successful experiences with plasma rich in platelets (PRP) in different clinical situations promoting angiogenesis. Thus, we considered the possibility of using it in the field of ovarian autologous transplantation in order to improve the vascularization of the implant and its quality. For this, both thawed ovarian tissue as practiced pockets on the rear side of the broad ligament which have been placed, have been impregnated with PRP. We can say that the implant treated in this way has had a rapid and successful response.We report a special interesting case because this is the first time that this technique is performed successfully in a woman without ovaries combined with growth factors to promote neoangiogenesis. Obviously, the results of the hormonal response come exclusively from the implanted tissue in these special conditions.
authors: Department of Obstetrics and Gynecology, Hospital Sant Joan de Déu, Faculty of Medicine-University of Barcelona, Barcelona, Spain. callejo@hsjdbcn.org.
authors: Justo
authors: J
authors: Callejo
authors: Cristina
authors: C
authors: Salvador
authors: Santiago
authors: S
authors: González-Nuñez
authors: Laura
authors: L
authors: Almeida
authors: Luciano
authors: L
authors: Rodriguez
authors: Laura
authors: L
authors: Marqués
authors: Ana
authors: A
authors: Valls
authors: José Maria
authors: JM
authors: Lailla
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