title: Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults.
abstract: Recent data suggest excess circulating aldosterone promotes cardiometabolic decline. Weight loss may lower aldosterone levels, but little longitudinal data is available in normotensive adults. We aimed to determine whether, independent of changes in sodium excretion, reductions in serum aldosterone are associated with favorable changes in obesity-related factors in normotensive overweight/obese young adults. We studied 285 overweight/obese young adult participants (body mass index ≥ 25 and<40 kg m⁻², age 20-45 years) in a clinical trial examining the effects of a 1-year diet and physical activity intervention with or without sodium restriction on vascular health. Body weight, serum aldosterone, 24-h sodium and potassium excretion and obesity-related factors were measured at baseline, 6, 12 and 24 months. Weight loss was significant at 6 (7%), 12 (6%) and 24 months (4%; all P<0.0001). Decreases in aldosterone were associated with decreases in C-reactive protein, leptin, insulin, homeostasis assessment of insulin resistance, heart rate, tonic cardiac sympathovagal balance and increases in adiponectin (all P<0.05) in models adjusting for baseline age, sex, race, intervention arm, time since baseline, and sodium and potassium excretion. Weight loss and reductions in thigh intermuscular fat (intermuscular adipose tissue area; IMAT) were associated with decreases in aldosterone in the subgroup (n=98) with metabolic syndrome (MetS) at baseline (MetS × weight loss, P=0.04; MetS × change in IMAT, P=0.04). Favorable changes in obesity-related factors are associated with reductions in aldosterone in young adults with no risk factors besides excess weight, an important finding, given aldosterone's emergence as an important cardiometabolic risk factor.
authors: 1] Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
authors: Jennifer N
authors: JN
authors: Cooper
authors: Linda
authors: L
authors: Fried
authors: Ping
authors: P
authors: Tepper
authors: Emma
authors: E
authors: Barinas-Mitchell
authors: Molly B
authors: MB
authors: Conroy
authors: Rhobert W
authors: RW
authors: Evans
authors: Maria
authors: M
authors: Mori Brooks
authors: Genevieve A
authors: GA
authors: Woodard
authors: Kim
authors: K
authors: Sutton-Tyrrell
mesh_terms: D052242:Adiponectin / Q000097:blood; D050154:Adiposity / Q000502:physiology; D000328:Adult; D000450:Aldosterone / Q000097:blood*; D001794:Blood Pressure / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism; D004039:Diet, Sodium-Restricted; D005260:Female; D005500:Follow-Up Studies; D054439:Ghrelin / Q000097:blood; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000097:blood; D008019:Life Style; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000503:physiopathology; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D050177:Overweight / Q000097:blood* / Q000503:physiopathology* / Q000628:therapy; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine
chemical_list: D052242:Adiponectin; D054439:Ghrelin; D020738:Leptin; D000450:Aldosterone; D002097:C-Reactive Protein; D012964:Sodium; D011188:Potassium
references: Eur Heart J. 2008 Dec;29(24):2959-71
references: 18775919
references: Obes Res. 2002 Oct;10(10):985-90
references: 12376578
references: Am J Kidney Dis. 1996 Jun;27(6):809-18
references: 8651245
references: J Clin Endocrinol Metab. 2008 Jul;93(7):2566-71
references: 18445663
references: J Renin Angiotensin Aldosterone Syst. 2006 Mar;7(1):31-9
references: 17083071
references: Int J Mol Med. 2006 Jun;17(6):975-80
references: 16685404
references: Arterioscler Thromb Vasc Biol. 2005 Nov;25(11):2243-4
references: 16258150
references: J Trauma. 2008 Dec;65(6):1364-73
references: 19077628
references: Am J Hypertens. 2010 Apr;23(4):425-31
references: 20057360
references: Hypertension. 2004 Feb;43(2):358-63
references: 14718355
references: Circulation. 2005 Oct 25;112(17):2735-52
references: 16157765
references: Hypertens Res. 2012 Jan;35(1):4-16
references: 22048570
references: Conf Proc IEEE Eng Med Biol Soc. 2006;2006:1776-9
references: 17946068
references: Hypertension. 2012 May;59(5):1069-78
references: 22493070
references: Mol Cell Endocrinol. 2012 Mar 24;350(2):281-8
references: 21945603
references: Clin Endocrinol (Oxf). 2008 Dec;69(6):848-54
references: 18410552
references: Mayo Clin Proc. 2001 Sep;76(9):877-82
references: 11560297
references: Am J Hypertens. 2011 Jan;24(1):70-6
references: 20508622
references: Curr Opin Nephrol Hypertens. 2006 Mar;15(2):173-8
references: 16481885
references: Lancet. 2009 Mar 7;373(9666):829-35
references: 19223069
references: J Clin Endocrinol Metab. 2007 Nov;92(11):4472-5
references: 17726083
references: Hypertension. 2005 Aug;46(2):308-12
references: 15983240
references: Circulation. 2007 Aug 28;116(9):984-92
references: 17698726
references: N Engl J Med. 1989 Aug 31;321(9):580-5
references: 2668763
references: Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H742-51
references: 22081704
references: Prostaglandins Leukot Essent Fatty Acids. 1999 May-Jun;60(5-6):401-5
references: 10471129
references: Arch Intern Med. 2005 Apr 11;165(7):777-83
references: 15824297
references: Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14211-6
references: 14614137
references: FASEB J. 2008 May;22(5):1502-11
references: 18171693
references: J Hypertens. 2004 Oct;22(10):1977-82
references: 15361770
references: Exp Clin Endocrinol Diabetes. 2010 Nov;118(10):713-8
references: 20533176
references: N Engl J Med. 2004 Jul 1;351(1):33-41
references: 15229305
references: Circulation. 2005 Apr 19;111(15):1954-61
references: 15837949
references: Hypertension. 2005 Mar;45(3):356-62
references: 15630041
references: N Engl J Med. 1981 Apr 16;304(16):930-3
references: 7010165
references: Horm Metab Res. 2007 Sep;39(9):694-9
references: 17846979
references: Obes Res. 1999 Jul;7(4):355-62
references: 10440591
references: Trends Endocrinol Metab. 2009 Nov;20(9):444-51
references: 19800255
references: Cardiovasc Res. 2009 Oct 1;84(1):164-72
references: 19505930
references: Hypertens Res. 2010 Mar;33(3):236-42
references: 20075930
references: Clin Exp Hypertens. 2012;34(1):63-70
references: 22007645