title: A case of nicorandil-induced unilateral corneal ulceration.
abstract: Nicorandil, a second-generation nitro derivative, has been reported to induce single or multiple ulcerations in many locations, including oral, anal, perianal, vulvovaginal, perivulval, penile, gastrointestinal, colic, peristomal and skin locations. Ocular locations are now highly suspected. Herein, we report the case of a 78-year-old woman who experienced corneal ulceration at second cataract surgery (right eye) while being treated with nicorandil for 3 years. Four years before, she had had an uneventful first cataract surgery (left eye). The ulcers healed within 6 weeks after simple withdrawal of nicorandil, an expected delay for this type of chemical ulcer. The substitution of nicorandil with classic nitric oxide donors has already been done without complication. Surgical intervention is unnecessary and inappropriate. Case reports of ocular side effects induced by nicorandil are rare and probably underestimated.
authors: Department of Ophthalmology, CHU Nancy, Vandoeuvre lès Nancy, France.
authors: Fanny
authors: F
authors: Trechot
authors: Benjamine
authors: B
authors: Batta
authors: Nadine
authors: N
authors: Petitpain
authors: Marie C
authors: MC
authors: Bazard
authors: Karine
authors: K
authors: Angioi
authors: Philippe
authors: P
authors: Trechot
mesh_terms: D000368:Aged; D002386:Cataract / Q000188:drug therapy*; D003320:Corneal Ulcer / Q000139:chemically induced*; D005260:Female; D006801:Humans; D020108:Nicorandil / Q000009:adverse effects*; D009569:Nitric Oxide / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000009:adverse effects*
chemical_list: D014665:Vasodilator Agents; D020108:Nicorandil; D009569:Nitric Oxide
keywords: Chemically induced; Corneal ulcer; Injuries; Nicorandil
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