title: Renal cell carcinoma metastatic to thyroid gland, presenting like anaplastic carcinoma of thyroid.
abstract: Background. Renal cell carcinoma (RCC) has unpredictable and diverse behavior. The classic triad of hematuria, loin pain, and abdominal mass is uncommon. At time of diagnosis, 25%-30% of patients are found to have metastases. Bones, lungs, liver, and brain are the frequent sites of metastases. RCC with metastasis to the head and neck region and thyroid gland is the rarest manifestation and anaplastic carcinoma behaving metastatic thyroid mass is an extremely rare presentation of RCC. Case Presentation. A 56-year-old Saudi man with past history of right radical nephrectomy 5 years back presented with 3 months history of rapid increasing neck mass with dysphagia, presenting like anaplastic thyroid carcinoma. Tru-cut biopsy turned out to be metastatic renal cell carcinoma. Patient was treated with radiation therapy 30 Gy in 10 fractions to mass. Patient died 4 months after the discovery of anaplastic thyroid looking metastasis. Conclusion. Rapidly progressing thyroid metastases secondary to RCC are rare and found often unresectable which are not amenable to surgery. Palliative radiotherapy can be considered for such patients.
authors: Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh 59046, Saudi Arabia.
authors: Khalid
authors: K
authors: Riaz
authors: Mutahir A
authors: MA
authors: Tunio
authors: Mushabbab
authors: M
authors: Alasiri
authors: Asim Ali
authors: AA
authors: Elbagir Mohammad
authors: Muhammad Mohsin
authors: MM
authors: Fareed
references: Ann Oncol. 2010 Sep;21(9):1839-1845
references: 20139152
references: Surgery. 2010 Jan;147(1):65-71
references: 19878964
references: Acta Cytol. 1985 Sep-Oct;29(5):856-8
references: 3863434
references: Auris Nasus Larynx. 2004 Mar;31(1):95-100
references: 15041062
references: Cancer. 2002 Nov 1;95(9):1869-78
references: 12404280
references: Acta Cytol. 2004 Jan-Feb;48(1):64-8
references: 14969183