title: Unusual cytochrome p450 enzymes and reactions.
abstract: Cytochrome P450 enzymes primarily catalyze mixed-function oxidation reactions, plus some reductions and rearrangements of oxygenated species, e.g. prostaglandins. Most of these reactions can be rationalized in a paradigm involving Compound I, a high-valent iron-oxygen complex (FeO(3+)), to explain seemingly unusual reactions, including ring couplings, ring expansion and contraction, and fusion of substrates. Most P450s interact with flavoenzymes or iron-sulfur proteins to receive electrons from NAD(P)H. In some cases, P450s are fused to protein partners. Other P450s catalyze non-redox isomerization reactions. A number of permutations on the P450 theme reveal the diversity of cytochrome P450 form and function.
authors: Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA. f.guengerich@vanderbilt.edu
authors: F Peter
authors: FP
authors: Guengerich
authors: Andrew W
authors: AW
authors: Munro
mesh_terms: D000818:Animals; D055162:Biocatalysis; D003067:Coenzymes / Q000737:chemistry / Q000502:physiology; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry* / Q000502:physiology; D006801:Humans; D006900:Hydroxylation; D010084:Oxidation-Reduction; D011453:Prostaglandins / Q000096:biosynthesis; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000502:physiology
chemical_list: D003067:Coenzymes; D011453:Prostaglandins; D011993:Recombinant Fusion Proteins; D003577:Cytochrome P-450 Enzyme System
keywords: Cytochrome P450; Enzyme Catalysis; Enzyme Mechanisms; Flavin; Heme; Natural Products; Oxidation-Reduction
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