title: A two-level model for the analysis of syndrome of acute ischemic stroke: from diagnostic model to molecular mechanism.
abstract: Prompt and accurate diagnosis of acute ischemic stroke is critical to seek acute therapy. In traditional Chinese medicine (TCM) science, there is a comprehensive system of diagnosis and medical care of acute ischemic stroke. Here we introduce a two-level model for the analysis of TCM syndrome of acute ischemic stroke. Owing to the limitation of sample size and imbalance, we focused on the analysis of wind-phlegm collateral obstruction syndrome (Feng Tan Yu Zu Zheng). Firstly, a Support-Vector-Machine- (SVM-) based diagnostic model was set up through selection of core symptoms. After pairwise undersampling, we improved the performance of prediction and generated the core symptoms-based diagnostic model of wind-phlegm collateral obstruction syndrome. Next, Pathway Pattern-based method and MetaDrug platform were used to shed light on the molecular basis of the significance of core symptoms in three complementary aspects: symptom-gene-pathway multilayer correlation network, enriched pathways, and most relevant interaction network. The integration of diagnostic model and molecular mechanism analysis creates an interesting perspective for better understanding the syndrome. The two-level model would provide a new opportunity for the study of TCM syndromes.
authors: Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors: Wen
authors: W
authors: Dai
authors: Xi
authors: X
authors: Liu
authors: Zhichen
authors: Z
authors: Zhang
authors: Jianxin
authors: J
authors: Chen
authors: Rongjuan
authors: R
authors: Guo
authors: Hong
authors: H
authors: Zheng
authors: Xianglan
authors: X
authors: Jin
authors: Shaoxin
authors: S
authors: Wen
authors: Yibo
authors: Y
authors: Gao
authors: Tiangang
authors: T
authors: Li
authors: Peng
authors: P
authors: Lu
authors: Yunling
authors: Y
authors: Zhang
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