title: Host modulation in rheumatoid arthritis patients with TNF blockers significantly decreases biochemical parameters in periodontitis.
abstract: The aim of this study was to evaluate the effects of host modulation therapy on periodontal and biochemical parameters. Sixteen rheumatoid arthritis patients newly scheduled for anti-tumour necrosis factor (TNF) therapy were screened for 30 days. Periodontal parameters (clinical attachment level, probing pocket depth, bleeding on probing, plaque index and gingival index) as well as salivary and gingival crevicular fluid (GCF), interleukin (IL)-1β, IL-8 and monocyte chemoattractant protein-1 (MCP-1) levels of the patients were evaluated at baseline and on the 30th day of therapy. GCF volume, IL-1β and IL-8 levels (p = 0.007, p = 0.017 and p = 0.009, respectively) of the periodontitis patients significantly decreased. Although there was a decrease in all these parameters in healthy patients, it was below statistical significance. Salivary IL-8 and MCP-1 levels significantly decreased in periodontitis patients (p = 0.028 and p = 0.013, respectively), but IL-1β levels remained unchanged. These results suggest that TNF blockers may significantly modify host response in terms of biochemical parameters of the periodontium and may mask significant associations such as those reported between periodontitis and rheumatoid arthritis.
authors: Department of Periodontology, Faculty of Dentistry, Gaziantep University, 27310, Gaziantep, Turkey, k_ustun@yahoo.com.
authors: Kemal
authors: K
authors: Üstün
authors: Kamile
authors: K
authors: Erciyas
authors: Bünyamin
authors: B
authors: Kısacık
authors: Ufuk
authors: U
authors: Sezer
authors: Yavuz
authors: Y
authors: Pehlivan
authors: Serdar
authors: S
authors: Öztuzcu
authors: Hasan
authors: H
authors: Gündoğar
authors: Ahmet Mesut
authors: AM
authors: Onat
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D018932:Chemokine CCL2 / Q000378:metabolism; D003774:Dental Plaque Index; D005260:Female; D005883:Gingival Crevicular Fluid / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000628:therapy*; D053583:Interleukin-1beta / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010518:Periodontitis / Q000378:metabolism / Q000628:therapy*; D010519:Periodontium / Q000737:chemistry; D012463:Saliva / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*; D055815:Young Adult
chemical_list: C111835:CCL2 protein, human; C508606:CXCL8 protein, human; D018932:Chemokine CCL2; D053583:Interleukin-1beta; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha
references: Nature. 2003 May 15;423(6937):356-61
references: 12748655
references: Acta Odontol Scand. 1963 Dec;21:533-51
references: 14121956
references: Best Pract Res Clin Rheumatol. 2011 Aug;25(4):549-67
references: 22137924
references: J Dent Res. 2006 Jul;85(7):596-607
references: 16798858
references: Arthritis Rheum. 2000 Jan;43(1):38-47
references: 10643698
references: Infect Immun. 1992 Dec;60(12):5253-8
references: 1452358
references: J Clin Rheumatol. 2012 Jun;18(4):180-4
references: 22647860
references: Arthritis Rheum. 1996 Jul;39(7):1077-81
references: 8670314
references: Ann Periodontol. 1999 Dec;4(1):1-6
references: 10863370
references: J Periodontol. 1985 Mar;56(3):139-47
references: 3886871
references: Biochem Biophys Res Commun. 1989 Jul 31;162(2):694-700
references: 2787988
references: J Clin Periodontol. 2001 Mar;28(3):233-40
references: 11284536
references: Inflammation. 2013 Jun;36(3):665-9
references: 23296876
references: Arthritis Rheum. 2012 Oct;64(10):3083-94
references: 22576262
references: Mol Med Today. 1996 May;2(5):198-204
references: 8796888
references: Ann Periodontol. 1999 Dec;4(1):32-8
references: 10863373
references: J Periodontol. 2008 Sep;79(9):1645-51
references: 18771364
references: Blood. 1996 Mar 15;87(6):2095-147
references: 8630372
references: J Immunol. 1999 Aug 1;163(3):1521-8
references: 10415055
references: J Periodontol. 2009 Sep;80(9):1414-20
references: 19722791
references: Annu Rev Immunol. 1993;11:767-804
references: 8476577
references: Ann Periodontol. 1996 Nov;1(1):821-78
references: 9118282
references: Nat Rev Rheumatol. 2009 Apr;5(4):218-24
references: 19337286
references: J Clin Periodontol. 2004 Oct;31(10):829-34
references: 15367184
references: J Periodontol. 1993 May;64(5 Suppl):474-84
references: 8315570
references: Arthritis Rheum. 1988 Mar;31(3):315-24
references: 3358796
references: Acta Odontol Scand. 1964 Feb;22:121-35
references: 14158464
references: J Clin Periodontol. 2011 Mar;38 Suppl 11:85-105
references: 21323706
references: J Periodontol. 2008 Aug;79(8 Suppl):1592-600
references: 18673015
references: J Clin Periodontol. 2005;32 Suppl 6:108-29
references: 16128833
references: J Periodontol. 1998 Dec;69(12):1419-25
references: 9926773
references: Lancet. 1994 Oct 22;344(8930):1105-10
references: 7934491
references: Int Dent J. 1975 Dec;25(4):229-35
references: 1058834
references: J Periodontol. 1995 Oct;66(10):852-9
references: 8537867
references: J Bone Miner Res. 1989 Feb;4(1):113-8
references: 2785743
references: Arthritis Rheum. 1995 Jan;38(1):44-8
references: 7818570