title: Development in mechanisms of ischemic mitral regurgitation.
abstract: OBJECTIVE
  The clinical diagnosis and treatment of ischemia mitral regurgitation (IMR) remained difficult because of its unclear mechanisms. This paper reviews studies on the mechanisms of IMR during the last 20 years, and discusses the relevance of the various mechanisms.
  
  
  METHODS
  Data used in this review were mainly from CNKI and Pubmed in English. The search terms were "ischemia mitral regurgitation mechanism", "myocardial infarction" AND "mitral regurgitation".
  
  
  METHODS
  Articles were selected if they involved mechanisms of IMR.
  
  
  RESULTS
  IMR is one of the common complications of coronary artery disease. But currently, the clinical diagnosis and treatment of IMR remained difficult because of its unclear mechanisms.
  
  
  CONCLUSIONS
  For now, dominating theory of ischemic mitral regurgitation mechanisms are left ventricular remodeling, imbalance of leaflet tethering and the closing force, left ventricular dysfunction, changes in spatial structure of the annulus and the dyssynchrony of the left ventricular electromechanical activity.
authors: Department of Cardiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, China.
authors: Wei-lin
authors: WL
authors: Huang
authors: Qiang
authors: Q
authors: Fu
mesh_terms: D000818:Animals; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000209:etiology*; D017202:Myocardial Ischemia / Q000150:complications*; D010210:Papillary Muscles / Q000502:physiology; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000150:complications; D020257:Ventricular Remodeling