title: Correlation of endogenous hormonal levels, fibroglandular tissue volume and percent density measured using 3D MRI during one menstrual cycle.
abstract: BACKGROUND
  We measured breast density (BD) on MRI and correlated with endogenous hormonal levels.
  
  
  METHODS
  Twenty-four premenopausal women received four weekly breast MRI. A blood sample was collected on the same day of MRI. BD was measured using a computer-based algorithm. The generalized estimation equation method was applied to model mean fibroglandular tissue volume (FV) and mean percent density (PD) from predictor variables including estradiol, progesterone, and week during a cycle.
  
  
  RESULTS
  In week 3, a borderline significant correlation between estradiol and PD (r = 0.43, P = 0.04), estradiol and FV (r = 0.40, P = 0.05) and between progesterone and FV (r = 0.42, P = 0.04) was noted. The FV and PD measured in weeks 4 and 1 were higher than in weeks 2 and 3, adjusted for variation in endogenous estradiol and progesterone, indicating that the hormone change could not account for the changes in density. No lag effect of endogenous hormone on the change of FV or PD was noted (all P-values > 0.05).
  
  
  CONCLUSIONS
  Our results showed that BD is not strongly associated with the endogenous hormone. Their association with breast cancer risk was likely coming from different mechanisms, and they should be considered as independent risk factors.
authors: Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, Irvine, USA. jeonhc@uci.edu
authors: J H
authors: JH
authors: Chen
authors: W P
authors: WP
authors: Chen
authors: S
authors: S
authors: Chan
authors: D C
authors: DC
authors: Yeh
authors: M Y
authors: MY
authors: Su
authors: C E
authors: CE
authors: McLaren
mesh_terms: D000328:Adult; D001940:Breast / Q000166:cytology* / Q000502:physiology*; D001943:Breast Neoplasms / Q000453:epidemiology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008597:Menstrual Cycle; D008875:Middle Aged; D011374:Progesterone / Q000097:blood*; D012306:Risk; D055815:Young Adult
chemical_list: D011374:Progesterone; D004958:Estradiol
keywords: MRI; breast density; endogenous hormone; fibroglandular tissue volume; lag effect; percent density
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