title: Tissue fatty acid composition in obstructive sleep apnea and recurrent tonsillitis.
abstract: OBJECTIVE
  Tonsillar hypertrophy cells appear to have an altered lipid metabolism as evidenced by modulated inflammatory cytokines that affect tissue lipid metabolism. The aim of this study was to investigate differences in tissue fat composition between obstructive sleep apnea (OSA) and recurrent infective tonsillitis (RT) in children.
  
  
  METHODS
  Tonsillar tissues were collected from 114 patients with OSA and 92 patients with RT, aged 4-10 years, during tonsillectomy. The tissue lipid extracts were analyzed by gas liquid chromatography for a comprehensive fatty acid profile.
  
  
  RESULTS
  In the tonsillitis tissue, the levels of palmitoleic acid (16:1n-7; P=0.002) and oleic acid (18:1n-9; P=0.003) were higher, and the level of stearic acid (18:0; P=0.004) was lower than that in the hyperplastic tonsillar tissue. Overall, tonsillar tissue of patients with RT had a significant increase in the total monounsaturated fatty acids (+9.9%; P<0.001) and the fatty acid desaturation index (+20.5%; P<0.001). Furthermore, oleic acid content of tonsillar tissue was positively correlated with BMI (r=0.20, P=0.004), snoring (r=0.16, P=0.022) and hypertrophy grade (r=0.18, P=0.023), which remain significant in the subgroup analysis by hypertrophy type.
  
  
  CONCLUSIONS
  The change in the fatty acid composition may be regarded as an indicator of altered lipid metabolism occurring in vivo during human tonsillar hypertrophy, which might be linked to the severity or type of the tissue damage.
authors: Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Rana
authors: R
authors: Ezzedini
authors: Maryam
authors: M
authors: Darabi
authors: Babollah
authors: B
authors: Ghasemi
authors: Masoud
authors: M
authors: Darabi
authors: Shabnam
authors: S
authors: Fayezi
authors: Yalda
authors: Y
authors: Jabbari Moghaddam
authors: Amir
authors: A
authors: Mehdizadeh
authors: Shahin
authors: S
authors: Abdollahi
authors: Abasaad
authors: A
authors: Gharahdaghi
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001707:Biopsy, Needle; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002853:Chromatography, Liquid / Q000379:methods; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism*; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D019301:Oleic Acid / Q000378:metabolism; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D012016:Reference Values; D018570:Risk Assessment; D020181:Sleep Apnea, Obstructive / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D014068:Tonsillectomy / Q000379:methods; D014069:Tonsillitis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; C008757:palmitoleic acid; D019301:Oleic Acid