title: Dabigatran, intracranial hemorrhage, and the neurosurgeon.
abstract: Dabigatran etexilate (Pradaxa) is a novel oral anticoagulant that has gained FDA approval for the prevention of ischemic stroke and systemic embolism in patients with nonvalvular atrial fibrillation. In randomized trials, the incidence of hemorrhagic events has been demonstrated to be lower in patients treated with dabigatran compared with the traditional anticoagulant warfarin. However, dabigatran does not have reliable laboratory tests to measure levels of anticoagulation and there is no pharmacological antidote. These drawbacks are challenging in the setting of intracerebral hemorrhage. In this article, the authors provide background information on dabigatran, review the existing anecdotal experiences with treating intracerebral hemorrhage related to dabigatran therapy, present a case study of intracranial hemorrhage in a patient being treated with dabigatran, and suggest clinical management strategies. The development of reversal agents is urgently needed given the growing number of patients treated with this medication.
authors: Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, West Bank, Palestine.
authors: Ahmed J
authors: AJ
authors: Awad
authors: Brian P
authors: BP
authors: Walcott
authors: Christopher J
authors: CJ
authors: Stapleton
authors: Vijay
authors: V
authors: Yanamadala
authors: Brian V
authors: BV
authors: Nahed
authors: Jean-Valery
authors: JV
authors: Coumans
mesh_terms: D000369:Aged, 80 and over; D000818:Animals; D000991:Antithrombins / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D000069604:Dabigatran; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D009493:Neurosurgery / Q000379:methods*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000991:Antithrombins; D001562:Benzimidazoles; D015091:beta-Alanine; D000069604:Dabigatran