title: Risk factors and lethality of laboratory-confirmed bloodstream infection caused by non-skin contaminant pathogens in neonates.
abstract: OBJECTIVE
  To evaluate risk factors and lethality of late onset laboratory-confirmed bloodstream infection (LCBI) in a Brazilian neonatal unit for progressive care (NUPC).
  
  
  METHODS
  This was a case-control study, performed from 2008 to 2012. Cases were defined as all newborns with late onset LCBI, excluding patients with isolated common skin contaminants. Controls were newborns who showed no evidence of late onset LCBI, matched by weight and time of permanence in the NUPC. Variables were obtained in the Hospital Infection Control Committee (HICC) database. Analysis was performed using the Statistical Package for the Social Sciences (SPSS). The chi-squared test was used, and statistical significance was defined as p < 0.05, followed by multivariate analysis.
  
  
  RESULTS
  50 patients with late onset LCBI were matched with 100 patients without late onset LCBI. In the group of patients with late onset LCBI, a significant higher proportion of patients who underwent surgical procedures (p = 0.001) and who used central venous catheter (CVC) (p = 0.012) and mechanical ventilation (p = 0.001) was identified. In multivariate analysis, previous surgery and the use of CVC remained significantly associated with infection (p = 0.006 and p = 0.047; OR: 4.47 and 8.99, respectively). Enterobacteriacea was identified in 14 cases, with three (21.4%) deaths, and Staphylococcus aureus was identified in 20 cases, with three (15%) deaths.
  
  
  CONCLUSIONS
  Surgical procedures and CVC usage were significant risk factors for LCBI. Therefore, prevention practices for safe surgery and CVC insertion and manipulation are essential to reduce these infections, in addition to training and continuing education to surgical and assistance teams.
authors: Departamento de Pediatria, Faculdade de Medicina, Universidade Federal de Minas Gerais UFMG, Belo Horizonte, MG, Brazil. rmcromanelli@ig.com.br
authors: Roberta M C
authors: RM
authors: Romanelli
authors: Lêni M
authors: LM
authors: Anchieta
authors: Maria Vitoria A
authors: MV
authors: Mourão
authors: Flávia A
authors: FA
authors: Campos
authors: Flavia C
authors: FC
authors: Loyola
authors: Paulo Henrique O
authors: PH
authors: Mourão
authors: Guilherme A
authors: GA
authors: Armond
authors: Wanessa T
authors: WT
authors: Clemente
authors: Maria Cândida F
authors: MC
authors: Bouzada
mesh_terms: D055499:Catheter-Related Infections / Q000517:prevention & control; D062905:Central Venous Catheters / Q000382:microbiology*; D003428:Cross Infection / Q000382:microbiology* / Q000401:mortality; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D004756:Enterobacteriaceae Infections / Q000382:microbiology* / Q000401:mortality; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007362:Intensive Care Units; D007755:Laboratories, Hospital; D008297:Male; D012307:Risk Factors; D018805:Sepsis / Q000382:microbiology* / Q000401:mortality; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000401:mortality; D013997:Time Factors