title: Clinical impact of 8 prospective, randomized, multicenter glaucoma trials.
abstract: OBJECTIVE
  To determine the impact of 8 multicenter randomized clinical trials (RCTs) on glaucoma practice.
  
  
  METHODS
  An electronic survey was distributed to the members of the American Glaucoma Society (AGS). Each participant was asked 2 study-specific questions and 1 standard question common to all 8 RCTs assessing the study's impact on clinical practice. RCTs included in the survey were the Advanced Glaucoma Intervention Study (AGIS), Collaborative Initial Glaucoma Treatment Study (CIGTS), Collaborative Normal Tension Glaucoma (CNTG) Study, European Glaucoma Prevention Study (EGPS), Early Manifest Glaucoma Trial (EMGT), Glaucoma Laser Trial (GLT), Ocular Hypertension Treatment Study (OHTS), and Tube Versus Trabeculectomy (TVT) Study. A 5-point Likert scale was used for rating all responses. The practice setting and duration of glaucoma practice was determined for all AGS members who responded.
  
  
  RESULTS
  A total of 206 (23.0%) of 894 AGS members participated in the survey. Among those who responded, 46.4% were self classified as academic practitioners and 53.6% worked in a private practice setting. Mean Likert scores for the standard question evaluating the overall impact of the RCT were OHTS 4.47, CNTG Study 4.13, AGIS 3.78, TVT Study 3.53, EMGT 3.48, CIGTS 3.44, GLT 3.39, and 2.69 EGPS.
  
  
  CONCLUSIONS
  Substantial differences were observed in the clinical impact of several RCTs in glaucoma. The reported impact of each study likely reflects several factors including study timing, design, conduct, and interpretation of results.
authors: *Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL †Department of Ophthalmology, New York Eye and Ear Infirmary, New York ‡New York Medical College, Valhalla, NY §Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, NC ∥Department of Ophthalmology, Stanford University, Palo Alto, CA.
authors: Joseph F
authors: JF
authors: Panarelli
authors: Michael R
authors: MR
authors: Banitt
authors: Paul A
authors: PA
authors: Sidoti
authors: Donald L
authors: DL
authors: Budenz
authors: Kuldev
authors: K
authors: Singh
mesh_terms: D005901:Glaucoma / Q000175:diagnosis* / Q000628:therapy*; D006306:Health Surveys; D006801:Humans; D007429:Intraocular Pressure; D009885:Ophthalmology / Q000458:organization & administration / Q000706:statistics & numerical data*; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012955:Societies, Medical; D011795:Surveys and Questionnaires