title: Reticular macular disease is associated with multilobular geographic atrophy in age-related macular degeneration.
abstract: OBJECTIVE
  To investigate the incidence of reticular macular disease (RMD), a subphenotype of age-related macular degeneration, in multilobular geographic atrophy (GA) and its relation to GA progression.
  
  
  METHODS
  One hundred and fifty-seven eyes of 99 subjects with age-related macular degeneration, primary GA, and good quality autofluorescence, and/or infrared images were classified into unilobular GA (1 lesion) or multilobular GA (≥ 2 distinct and/or coalescent lesions). Thirty-four subjects (50 eyes) had serial imaging. The authors determined the spatiotemporal relationships of RMD to GA and GA progression rates in five macular fields.
  
  
  RESULTS
  91.7% eyes (144 of 157) had multilobular GA, 95.8% of which exhibited RMD. In subjects with serial imaging, the mean GA growth rate significantly differed between the unilobular and multilobular groups (0.40 vs. 1.30 mm2/year, P < 0.001). Of the macular fields in these eyes, 77.1% of fields with RMD at baseline showed subsequent GA progression, while 53.4% of fields without RMD showed progression (P < 0.001). Percentage of fields with RMD significantly correlated with GA progression rate (P = 0.01).
  
  
  CONCLUSIONS
  Autofluorescence and infrared imaging demonstrates that RMD is nearly always present with multilobular GA in age-related macular degeneration. Furthermore, GA lobules frequently develop in areas of RMD, suggesting progression of a single underlying disease process.
authors: *Department of Ophthalmology, E.S. Harkness Eye Institute, Columbia University, New York, New York; †Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah; and ‡Department of Ophthalmology, New York University Langone Medical Center, New York, New York.
authors: Luna
authors: L
authors: Xu
authors: Anna M
authors: AM
authors: Blonska
authors: Nicole M
authors: NM
authors: Pumariega
authors: Srilaxmi
authors: S
authors: Bearelly
authors: Mahsa A
authors: MA
authors: Sohrab
authors: Gregory S
authors: GS
authors: Hageman
authors: R Theodore
authors: RT
authors: Smith
mesh_terms: D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D057092:Geographic Atrophy / Q000145:classification / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000175:diagnosis; D008297:Male; D064847:Multimodal Imaging; D009887:Ophthalmoscopy; D015593:Retinal Drusen / Q000175:diagnosis; D058499:Retinal Dystrophies / Q000175:diagnosis / Q000209:etiology*; D055213:Retinal Pigment Epithelium / Q000473:pathology*
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