title: MicroRNAs as potential therapeutic targets in kidney disease.
abstract: One cornerstone of chronic kidney disease (CKD) is fibrosis, as kidneys are susceptible due to their high vascularity and predisposition to ischemia. Presently, only therapies targeting the angiotensin receptor are used in clinical practice to retard the progression of CKD. Thus, there is a pressing need for new therapies designed to treat the damaged kidney. Several independent laboratories have identified a number of microRNAs that are dysregulated in human and animal models of CKD. This review will explore the evidence suggesting that by blocking the activity of such dysregulated microRNAs, new therapeutics could be developed to treat the progression of CKD.
authors: Division of Nephrology, Seattle, WA, USA. igomez@uw.edu
authors: Ivan G
authors: IG
authors: Gomez
authors: Monica
authors: M
authors: Grafals
authors: Didier
authors: D
authors: Portilla
authors: Jeremy S
authors: JS
authors: Duffield
mesh_terms: D000818:Animals; D004847:Epithelial Cells / Q000473:pathology; D005355:Fibrosis; D005786:Gene Expression Regulation; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics / Q000628:therapy*; D035683:MicroRNAs / Q000037:antagonists & inhibitors* / Q000502:physiology
chemical_list: D035683:MicroRNAs
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