title: Indanomycin-related antibiotics from marine Streptomyces antibioticus PTZ0016.
abstract: Four indanomycin-related antibiotics 2-5 were isolated from the cultured broth of marine Streptomyces antibioticus strain PTZ0016. Their structures were characterised as 16-deethylindanomycin (2), iso-16-deethylindanomycin (3), 16-deethylindanomycin methyl ester (4) and iso-16-deethylindanomycin methyl ester (5) on the basis of NMR, HR-ESI-MS and CD evidences. Compounds 3-5 are new additions to the class of indanomycin antibiotics. All isolated compounds showed in vitro activity against Staphylococcus aureus with minimal inhibitory concentration at 4.0-8.0 μg/ml.
authors: a College of Pharmaceutical Sciences, Zhejiang University , Hangzhou , 310058 , P.R. China.
authors: Xiao-Yuan
authors: XY
authors: Lian
authors: Zhizhen
authors: Z
authors: Zhang
mesh_terms: D002942:Circular Dichroism; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D011714:Pyrans / Q000737:chemistry* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013211:Staphylococcus aureus / Q000187:drug effects; D013303:Streptomyces antibioticus / Q000737:chemistry*; D011758:Pyrroles
chemical_list: D011714:Pyrans; C114124:indanomycin; D011758:Pyrroles