title: Urine and serum microRNA-1 as novel biomarkers for myocardial injury in open-heart surgeries with cardiopulmonary bypass.
abstract: MicroRNA-1 (miR-1) is a cardio-specific/enriched microRNA. Our recent studies have revealed that serum and urine miR-1 could be a novel sensitive biomarker for acute myocardial infarction. Open-heart surgeries with cardiopulmonary bypass (CPB) are often accompanied with surgery injury and CPB-associated injury on the hearts. However, the association of miR-1 and these intra-operative and post-operative cardiac injures is unknown. The objective of this study was to test the hypothesis that urine and serum miR-1 might be a novel biomarker for myocardial injuries in open-heart surgeries with CPB. Serum and urine miR-1 levels in 20 patients with elective mitral valve surgery were measured at pre-surgery, pre-CPB, 60 min post-CBP, and 24h post-CBP. Serum cardiac troponin-I (cTnI) was used as a positive control biomarker for cardiac injury. Compared with these in pre-operative and pre-CPB groups, the levels of miR-1 in serum and urine from patients after open-heart surgeries and CPB were significant increased at all observed time points. A similar pattern of serum cTnI levels and their strong positive correlation with miR-1 levels were identified in these patients. The results suggest that serum and urine miR-1 may be a novel sensitive biomarker for myocardial injury in open-heart surgeries with CPB.
authors: Department of Internal Medicine and Anesthesiology and Critical Care Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China.
authors: Xian
authors: X
authors: Zhou
authors: Anqiong
authors: A
authors: Mao
authors: Xiaobin
authors: X
authors: Wang
authors: Xiaoxia
authors: X
authors: Duan
authors: Yi
authors: Y
authors: Yao
authors: Chunxiang
authors: C
authors: Zhang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000097:blood / Q000209:etiology / Q000652:urine*; D008297:Male; D035683:MicroRNAs / Q000097:blood / Q000652:urine*; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D009206:Myocardium / Q000473:pathology; D019210:Troponin I / Q000097:blood
chemical_list: D015415:Biomarkers; C544547:MIRN1 microRNA, human; D035683:MicroRNAs; D019210:Troponin I
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