title: [Effect of electroacupuncture combined with cervical plexus block on stress responses in patients undergoing thyroid surgery].
abstract: OBJECTIVE
  To observe the effect of electroacupuncture (EA) combined with cervical plexus block (CPB) on the stress response of patients undergoing thyroid surgery.
  
  
  METHODS
  Forty thyroidectomy patients were randomly divided into sham EA plus CPB group (sham group) and EA+CPB group (20 cases in each group). For patients of the sham group, deep cervical plexus block (25% ropivacaine hydrochloride + 1% lidocaine hydrochloride) was performed first, followed by inserting acupuncture needles into bilateral Hegu (LI 4) and Neiguan (PC 6) separately without needle manipulation and then connecting the output wires of the EA therapeutic instrument to the handles of the acupuncture needles but without electric current output. For patients of the EA+CPB group, deep cervical plexus block was performed first followed by EA stimulation [10 Hz, (6 +/- 2) mA] of the bilateral LI 4 and PC 6 for 20 min. Systolic blood pressure (SBP), heart rate (HR) and breathing frequency were detected using a multipurpose monitor. Plasma adrenocorticotropic hormone (ACTH) and cortisol (Cor) contents were determined using chemiluminescence method, plasma epinephrine (E) level was detected by enzyme-linked immunosorbent assay, glucose (Glu) assayed by oxidase method, and plasma C-reactive protein (CRP) level detected using immumofluorescence technique.
  
  
  RESULTS
  (1) During surgery, the patients' SBP and HR of both sham and EA groups were increased significantly compared with their basic values (P < 0.05), but the levels of the increased SBP and HR of the EA group were obviously lower than those of the sham group (P < 0.05). (2) The levels of plasma ACTH during surgery and at the immediate time after surgery, Cor level at the immediate time after surgery, plasma E and Glu contents during surgery, at the immediate time and on day 1 after surgery, and plasma CRP at the immediate time, and on day 1 and 3 after surgery in the sham group were upregulated considerably (P < 0.05), while the levels of plasma ACTH, Cor, E, Glu and CRP in the above-mentioned time-points of the EA group were all remarkably lower than those of the sham group (P < 0.05).
  
  
  CONCLUSIONS
  EA combined with cervical plexus block significantly reduces peri-operative cardiovascular stress responses and inhibits abnormal increases of plasma stress hormones and inflammatory reaction in patients undergoing thyroid surgery.
authors: The First People's Hospital of Nanyang City of Henan Province, Nanyang 473000, China. zhangcaiju111@163.com
authors: Cai-Ju
authors: CJ
authors: Zhang
authors: Fan
authors: F
authors: Yang
authors: Man
authors: M
authors: Li
mesh_terms: D015667:Acupuncture Analgesia; D015669:Acupuncture Points; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D002572:Cervical Plexus / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D015671:Electroacupuncture; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D013959:Thyroid Diseases / Q000503:physiopathology* / Q000601:surgery*; D055815:Young Adult
chemical_list: D000324:Adrenocorticotropic Hormone; D002097:C-Reactive Protein