title: Clinical and histological evaluation of postextraction platelet-rich fibrin socket filling: a prospective randomized controlled study.
abstract: OBJECTIVE
  The aims were to investigate whether the use of platelet-rich fibrin membranes (PRF) for socket filling could improve microarchitecture and intrinsic bone tissue quality of the alveolar bone after premolar extraction and to assess the influence of the surgical procedure before implant placement.
  
  
  METHODS
  Twenty-three patients requiring premolar extraction followed by implant placement were randomized to three groups: (1) simple extraction and socket filling with PRF, (2) extraction with mucosal flap and socket filling with PRF, and (3) controls with simple extraction without socket filling. Implant placement was performed at week 8, and a bone biopsy was obtained for histomorphometric analysis.
  
  
  RESULTS
  Analysis by microcomputed tomography showed better bone healing with improvement of the microarchitecture (P < 0.05) in group 1. This treatment had also a significant effect (P < 0.05) on intrinsic bone tissue quality and preservation of the alveolar width. An invasive surgical procedure with a mucosal flap appeared to completely neutralize the advantages of the PRF.
  
  
  CONCLUSIONS
  These results support the use of a minimally traumatic procedure for tooth extraction and socket filling with PRF to achieve preservation of hard tissue.
authors: Department of Oral Surgery, Oral Medicine, Oral and Maxillofacial Radiology, School of Dental Medicine, University of Geneva, Geneva, Switzerland. fabien@hauser.net
authors: Fabien
authors: F
authors: Hauser
authors: Nikolay
authors: N
authors: Gaydarov
authors: Isabelle
authors: I
authors: Badoud
authors: Lydia
authors: L
authors: Vazquez
authors: Jean-Pierre
authors: JP
authors: Bernard
authors: Patrick
authors: P
authors: Ammann
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000209:etiology; D000539:Alveolar Process / Q000187:drug effects; D000704:Analysis of Variance; D001792:Blood Platelets; D001861:Bone Regeneration / Q000187:drug effects*; D003758:Dental Implantation, Endosseous; D004435:Eating; D005260:Female; D005337:Fibrin / Q000494:pharmacology*; D006245:Hardness Tests; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D014081:Tooth Extraction / Q000009:adverse effects / Q000379:methods; D020390:Tooth Socket / Q000000981:diagnostic imaging / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects; D055114:X-Ray Microtomography; D055815:Young Adult
chemical_list: D008567:Membranes, Artificial; D005337:Fibrin