title: Endoglin: a critical mediator of cardiovascular health.
abstract: Endoglin (CD105) is a type III auxiliary receptor for the transforming growth factor beta (TGFβ) superfamily. Several lines of evidence suggest that endoglin plays a critical role in maintaining cardiovascular homeostasis. Seemingly disparate disease conditions, including hereditary hemorrhagic telangiectasia, pre-eclampsia, and cardiac fibrosis, have now been associated with endoglin. Given the central role of the TGFβ superfamily in multiple disease conditions, this review provides a detailed update on endoglin as an evolving therapeutic target in the management of cardiovascular disease.
authors: Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. nkapur@tuftsmedicalcenter.org
authors: Navin K
authors: NK
authors: Kapur
authors: Kevin J
authors: KJ
authors: Morine
authors: Michelle
authors: M
authors: Letarte
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D002319:Cardiovascular System / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D000071063:Endoglin; D005260:Female; D006706:Homeostasis; D006801:Humans; D008024:Ligands; D008297:Male; D011225:Pre-Eclampsia / Q000378:metabolism; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D020257:Ventricular Remodeling
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D008024:Ligands; D011956:Receptors, Cell Surface; D016212:Transforming Growth Factor beta
keywords: cardiac remodeling; endoglin; transforming growth factor beta; vascular
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