title: Conformational regulation of substituted azepanes through selective monofluorination.
abstract: Substituted azepanes are common bioactive epitopes with flexible ring structures. The conformational effects of monofluorination in model azepane rings were investigated by (1)H NMR spectroscopy and computational modelling. A single fluorine atom, installed diastereoselectively, was found to bias the azepane ring to one major conformation for one diastereomer.
authors: Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney NSW 2109, Australia.
authors: Alpesh Ramanlal
authors: AR
authors: Patel
authors: Graham
authors: G
authors: Ball
authors: Luke
authors: L
authors: Hunter
authors: Fei
authors: F
authors: Liu