title: Quantitative contrast-enhanced ultrasound comparison between inflammatory and fibrotic lesions in patients with Crohn's disease.
abstract: The aim of this study was to determine whether there are differences in absolute blood flow between patients with Crohn's disease with inflammation or fibrosis using contrast-enhanced ultrasound. Eighteen patients with fibrotic disease and 19 patients with inflammation were examined. Video sequences of contrast data were analyzed using a pharmacokinetic model to extract the arterial input and tissue residue functions with a custom software, enabling calculation of the absolute values for mean transit time, blood volume and flow. Feasibility of the examination was 89%. The fibrosis group had lower blood volume (0.9 vs. 3.4 mL per 100 mL tissue; p = 0.001) and flow (22.6 vs. 45.3 mL/min per 100 mL tissue; p = 0.003) compared with the inflammation group. There was no significant difference in mean transit time (3.9 vs. 5.5 s). In conclusion, absolute perfusion measurement in the gastrointestinal wall using contrast-enhanced ultrasound is feasible. There seems to be reduced blood volume and blood flow in patients with fibrotic disease.
authors: Institute of Medicine, University of Bergen, Bergen, Norway. mpkkn@med.uib.no
authors: Kim
authors: K
authors: Nylund
authors: Radovan
authors: R
authors: Jirik
authors: Martin
authors: M
authors: Mezl
authors: Sabine
authors: S
authors: Leh
authors: Trygve
authors: T
authors: Hausken
authors: Frank
authors: F
authors: Pfeffer
authors: Svein
authors: S
authors: Ødegaard
authors: Torfinn
authors: T
authors: Taxt
authors: Odd Helge
authors: OH
authors: Gilja
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D003287:Contrast Media; D003424:Crohn Disease / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D004751:Enteritis / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D005355:Fibrosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007422:Intestines / Q000473:pathology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013459:Sulfur Hexafluoride; D014463:Ultrasonography / Q000379:methods*
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride