title: Peptide-binding motifs and characteristics for HLA -B*13:01 molecule.
abstract: Trichloroethylene (TCE)-induced hypersensitivity dermatitis is one of the critical occupational diseases among workers in China. Our previous studies have identified a strong linkage between the disease and the HLA-B*13:01 allele. In this study, we searched for peptides bound to the HLA-B*13:01 molecule; 57 HLA-B*13:01-bound peptides in total were identified and 54 peptides were used to calculate frequency of amino acid residues to obtain binding motifs of HLA-B*13:01 molecule. The results showed P2, P3, and P9 were the primary binding anchor positions with the dominant anchor motifs of L, Q at P2, L at P9, D at P3. HLA-B*13:01-bound peptides were identified for the first time in our research, the results of which could contribute to the human leukocyte antigen (HLA)-binding peptides database.
authors: Key laboratory of Chemical Safety and Health, Chinese Centre for Disease Control and Prevention, National Institute for Occupational Health and Poison Control, Chinese Centre for Disease Control and Prevention, Beijing, China.
authors: J
authors: J
authors: Zhang
authors: H
authors: H
authors: Yang
authors: H
authors: H
authors: Li
authors: F
authors: F
authors: Liu
authors: Q
authors: Q
authors: Jia
authors: H
authors: H
authors: Duan
authors: Y
authors: Y
authors: Niu
authors: P
authors: P
authors: Bin
authors: Y
authors: Y
authors: Zheng
authors: Y
authors: Y
authors: Dai
mesh_terms: D000483:Alleles; D001665:Binding Sites / Q000235:genetics; D045744:Cell Line, Tumor; D002681:China; D019295:Computational Biology; D009783:Dermatitis, Occupational / Q000209:etiology / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D059908:HLA-B13 Antigen / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D010446:Peptide Fragments / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D011110:Polymorphism, Genetic; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D014241:Trichloroethylene / Q000009:adverse effects
chemical_list: D059908:HLA-B13 Antigen; D010446:Peptide Fragments; D014241:Trichloroethylene