title: [Erythropoietin in plastic surgery].
abstract: EPO is an autologous hormone, which is known to regulate erythropoiesis. For 30 years it has been used for the therapy of diverse forms of anaemia, such as renal anaemia, tumour-related anaemias, etc. Meanwhile, a multitude of scientific publications were able to demonstrate its pro-regenerative effects after trauma. These include short-term effects such as the inhibition of the "primary injury response" or apoptosis, and mid- and long-term effects for example the stimulation of stem cell recruitment, growth factor production, angiogenesis and re-epithelialisation. Known adverse reactions are increases of thromboembolic events and blood pressure, as well as a higher mortality in patients with tumour anaemias treated with EPO. Scientific investigations of EPO in the field of plastic surgery included: free and local flaps, nerve regeneration, wound healing enhancement after dermal thermal injuries and in chronic wounds.Acute evidence for the clinical use of EPO in the field of plastic surgery is still not satisfactory, due to the insufficient number of Good Clinical Practice (GCP)-conform clinical trials. Thus, the initiation of more scientifically sound trials is indicated.
authors: Klinik und Poliklinik für Plastische Chirurgie und Handchirurgie, Klinikum rechts der Isar, Technische Universität München, München. Christina.Guenter@lrz.tum.de
authors: C I
authors: CI
authors: Günter
authors: F
authors: F
authors: Rezaeian
authors: Y
authors: Y
authors: Harder
authors: J A
authors: JA
authors: Lohmeyer
authors: S
authors: S
authors: Egert
authors: A
authors: A
authors: Bader
authors: A F
authors: AF
authors: Schilling
authors: H-G
authors: HG
authors: Machens
mesh_terms: D000740:Anemia / Q000188:drug therapy / Q000503:physiopathology; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004921:Erythropoietin / Q000009:adverse effects / Q000502:physiology / Q000627:therapeutic use*; D006085:Graft Survival / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology; D019651:Plastic Surgery Procedures / Q000379:methods*; D044968:Regenerative Medicine / Q000379:methods; D012867:Skin / Q000293:injuries; D013524:Surgical Flaps / Q000502:physiology / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology; D014947:Wounds and Injuries / Q000503:physiopathology / Q000601:surgery
chemical_list: D004921:Erythropoietin