title: Mutagenic activation reduces carcinogenic activity of ortho-aminoazotoluene for mouse liver.
abstract: Pentachlorophenol (aromatic amine and azo stain metabolic stimulation inhibitor) reduced the hepatocarcinogenic activity of 4-aminoazobenzene and reduced that of ortho-aminoazotoluene in suckling mice. Both 4-aminoazobenzene and ortho-aminoazotoluene exhibited mutagenic activity in Ames' test in vitro on S. typhimurium TA 98 strain with activation with liver enzymes; this mutagenic activity was similarly suppressed by adding pentachlorophenol into activation medium. Induction of xenobiotic metabolism enzymes, stimulating the mutagenic activity of ortho-aminoazotoluene, suppressed its carcinogenic effect on mouse liver. Hence, ortho-aminotoluene (the initial compound), but not its mutagenic metabolites, was the direct active hepatocarcinogen for mice.
authors: Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors: L P
authors: LP
authors: Ovchinnikova
authors: L A
authors: LA
authors: Bogdanova
authors: V I
authors: VI
authors: Kaledin
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000378:metabolism* / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008813:Mice, Inbred ICR; D009152:Mutagenicity Tests; D010416:Pentachlorophenol / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D009762:o-Aminoazotoluene / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity
chemical_list: D002273:Carcinogens; D010416:Pentachlorophenol; D009762:o-Aminoazotoluene