title: Urethral dilatation: Is there any benefit over cystoscopy and distension? A randomized trial in women with overactive bladder symptoms.
abstract: OBJECTIVE
  To evaluate the effect of urethral dilatation (UD) on urgency symptoms in women with overactive bladder (OAB) and voiding dysfunction.
  
  
  METHODS
  Women with OAB symptoms and a maximum flow rate of less than 15 ml/sec on a volume voided of 200 ml were eligible for entry to the trial. Fifty women with OAB symptoms and a maximum flow rate of less than 15 ml/sec on a volume voided of over 200 ml were randomized to undergo UD plus cystoscopy or cystoscopy alone. All subjects underwent filling and voiding cystometry pre-operatively and at 6 weeks' post-operatively. Subjective outcomes were assessed using the Urgency Perception Scale (UPS) and King's Health Questionnaire at baseline, 6 weeks and 6 months. The primary outcome measure was cure of urgency, defined using the UPS.
  
  
  RESULTS
  Urgency was cured in 10/22 (45%) patients in the UD group and 5/28 (18%) in the non-UD group at 6 weeks (Odds ratio 3.8, 95% confidence interval 1.1-13.8, P = 0.03). Cystometric flow data were available for all patients pre- and post-UD. UD was associated with a significant increase in the flow rate centile from 1.66 to 8.54 (P = 0.01). At 6 months there was no benefit from UD with 4/22 in the UD group cured of urgency and 4/28 in the non-UD group cured (Odds ratio 1.3, 95% confidence interval 0.3-6.1, P = 0.50).
  
  
  CONCLUSIONS
  UD confers a significant short-term benefit in cure of urgency over cystoscopy alone, but there is no significant benefit in symptom relief in the long term.
authors: Department of Urogynaecology and Pelvic Floor Reconstructive Surgery, St. George's Hospital, London, United Kingdom.
authors: Maya
authors: M
authors: Basu
authors: Vik
authors: V
authors: Khullar
authors: Jonathan
authors: J
authors: Duckett
mesh_terms: D003131:Combined Modality Therapy; D003558:Cystoscopy / Q000009:adverse effects; D004106:Dilatation / Q000009:adverse effects; D004739:England; D005260:Female; D006801:Humans; D008875:Middle Aged; D020127:Recovery of Function; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014521:Urethra / Q000503:physiopathology*; D001743:Urinary Bladder / Q000503:physiopathology*; D053201:Urinary Bladder, Overactive / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D053202:Urinary Incontinence, Urge / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D014563:Urodynamics
keywords: overactive bladder; urethral dilatation; voiding