title: Decreasing cardiovascular risk factors in obese individuals using a combination of PGX® meal replacements and PGX® granules in a 12-week clinical weight modification program.
abstract: In this open, clinically based, weight modification program, we determined in six sedentary obese adults (five women; one male; age range 30-62 years) that the combination of a modified calorie diet plus PGX® meal replacement and PGX® supplementation resulted in a significant reduction in several cardiovascular risk factors over a 12-week time period. This included a significant improvement in lipids (-0.98 mmol/l LDL-C), reduction in average weight (-9.2 kg), mean reduction in fat (-4.1%) and an increase in fat-free mass (2.8%).
authors: Canadian Centre for Functional Medicine, Coquitlam, BC, Canada. doctorreichert@functionalmedicine.ca
authors: Ronald G
authors: RG
authors: Reichert
authors: Michael R
authors: MR
authors: Lyon
authors: Veronica
authors: V
authors: Kacinik
authors: Roland J
authors: RJ
authors: Gahler
authors: Priya
authors: P
authors: Manjoo
authors: Monica
authors: M
authors: Purnama
authors: Simon
authors: S
authors: Wood
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000328:Adult; D000464:Alginates / Q000494:pharmacology / Q000627:therapeutic use; D001823:Body Composition / Q000187:drug effects*; D001825:Body Fluid Compartments / Q000187:drug effects; D031204:Caloric Restriction; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D008078:Cholesterol, LDL / Q000097:blood; D004038:Diet, Reducing; D004043:Dietary Fiber / Q000494:pharmacology / Q000627:therapeutic use*; D019587:Dietary Supplements; D005260:Female; D020723:Glucuronic Acid / Q000494:pharmacology / Q000627:therapeutic use; D006603:Hexuronic Acids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008351:Mannans / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D011135:Polysaccharides, Bacterial / Q000494:pharmacology / Q000627:therapeutic use; D012307:Risk Factors; D057185:Sedentary Behavior; D015431:Weight Loss / Q000187:drug effects*; D061217:Weight Reduction Programs
chemical_list: D000464:Alginates; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D006603:Hexuronic Acids; D008351:Mannans; D011135:Polysaccharides, Bacterial; C022901:(1-6)-alpha-glucomannan; D020723:Glucuronic Acid; C002563:xanthan gum