title: A prospective observational study of 468 patients undergoing D2 or D3 lymphadenectomy for gastric cancer.
abstract: OBJECTIVE
  A single-center, prospective observational study was performed to evaluate outcomes in patients undergoing D2 or D3 lymphadenectomy for gastric cancer.
  
  
  METHODS
  Lymphadenectomies were performed according to the classification published by the Japanese Gastric Cancer Association.
  
  
  RESULTS
  Of 468 consecutive patients, 370 underwent D2 and 98 underwent D3 lymphadenectomy. Postoperative complications were significantly less common in the D2 group than in the D3 group (19.2% vs. 35.7%, p=0.001). Postoperative mortality in the two groups was similar, being 3.8% in the D2 group and 5.1% in the D3 group (p>0.05). Median postoperative survival times were also similar, in the D2 group being 37.8 months (95% CI: 23-52.5), and in the D3 group 30.2 months (95% CI: 13-47.3, p>0.05).
  
  
  CONCLUSIONS
  In patients who underwent gastrectomy with curative intent, lymphadenectomy that was more extensive than D2 did not provide a survival benefit compared to D2 dissection.
authors: Department of Gastroenterological Surgery, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey. ebbostanci@yahoo.com
authors: Erdal Birol
authors: EB
authors: Bostanci
authors: Ilter
authors: I
authors: Ozer
authors: Metin
authors: M
authors: Ercan
authors: Murat
authors: M
authors: Ulas
authors: Umit
authors: U
authors: Koc
authors: Kerem
authors: K
authors: Karaman
authors: Tahsin
authors: T
authors: Dalgic
authors: Yusuf
authors: Y
authors: Ozogul
authors: Musa
authors: M
authors: Akoglu
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008197:Lymph Node Excision / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome