title: Combat Wound Initiative program.
abstract: The Combat Wound Initiative (CWI) program is a collaborative, multidisciplinary, and interservice public-private partnership that provides personalized, state-of-the-art, and complex wound care via targeted clinical and translational research. The CWI uses a bench-to-bedside approach to translational research, including the rapid development of a human extracorporeal shock wave therapy (ESWT) study in complex wounds after establishing the potential efficacy, biologic mechanisms, and safety of this treatment modality in a murine model. Additional clinical trials include the prospective use of clinical data, serum and wound biomarkers, and wound gene expression profiles to predict wound healing/failure and additional clinical patient outcomes following combat-related trauma. These clinical research data are analyzed using machine-based learning algorithms to develop predictive treatment models to guide clinical decision-making. Future CWI directions include additional clinical trials and study centers and the refinement and deployment of our genetically driven, personalized medicine initiative to provide patient-specific care across multiple medical disciplines, with an emphasis on combat casualty care.
authors: Walter Reed Army Medical Center, Department of Surgery, 6900 Georgia Avenue NW, Washington, DC 20307, USA.
authors: Alexander
authors: A
authors: Stojadinovic
authors: Eric
authors: E
authors: Elster
authors: Benjamin K
authors: BK
authors: Potter
authors: Thomas A
authors: TA
authors: Davis
authors: Doug K
authors: DK
authors: Tadaki
authors: Trevor S
authors: TS
authors: Brown
authors: Stephen
authors: S
authors: Ahlers
authors: Christopher E
authors: CE
authors: Attinger
authors: Romney C
authors: RC
authors: Andersen
authors: David
authors: D
authors: Burris
authors: Jose
authors: J
authors: Centeno
authors: Hunter
authors: H
authors: Champion
authors: David R
authors: DR
authors: Crumbley
authors: John
authors: J
authors: Denobile
authors: Michael
authors: M
authors: Duga
authors: James R
authors: JR
authors: Dunne
authors: John
authors: J
authors: Eberhardt
authors: William J
authors: WJ
authors: Ennis
authors: Jonathan A
authors: JA
authors: Forsberg
authors: Jason
authors: J
authors: Hawksworth
authors: Thomas S
authors: TS
authors: Helling
authors: Gerald S
authors: GS
authors: Lazarus
authors: Stephen M
authors: SM
authors: Milner
authors: Florabel G
authors: FG
authors: Mullick
authors: Christopher R
authors: CR
authors: Owner
authors: Paul F
authors: PF
authors: Pasquina
authors: Chirag R
authors: CR
authors: Patel
authors: George E
authors: GE
authors: Peoples
authors: Aviram
authors: A
authors: Nissan
authors: Michael
authors: M
authors: Ring
authors: Glenn D
authors: GD
authors: Sandberg
authors: Wolfgang
authors: W
authors: Schaden
authors: Gregory S
authors: GS
authors: Schultz
authors: Tom
authors: T
authors: Scofield
authors: Scott B
authors: SB
authors: Shawen
authors: Forest R
authors: FR
authors: Sheppard
authors: James P
authors: JP
authors: Stannard
authors: Peter J
authors: PJ
authors: Weina
authors: Jonathan M
authors: JM
authors: Zenilman
mesh_terms: D015415:Biomarkers; D002056:Burns / Q000628:therapy; D002986:Clinical Trials as Topic; D019220:High-Energy Shock Waves / Q000627:therapeutic use*; D006801:Humans; D008889:Military Personnel; D018919:Neovascularization, Physiologic; D055818:Public-Private Sector Partnerships; D057170:Translational Research, Biomedical; D014481:United States; D014857:Warfare; D014945:Wound Healing; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D015415:Biomarkers