title: Anticoagulant effects of arginine-containing peptide Arg-Pro-Gly-Pro under conditions of immobilization stress.
abstract: Anticoagulant, fibrinolytic, and antiplatelet effects of RPGP peptide were found in animals under stress conditions caused by single or repeated immobilization. The observed properties of the peptide extend the study of agents protecting the organism under conditions of hypercoagulation occurring under stress conditions and help to re-evaluate the role of glyprolines as contributors to the maintenance of adaptation capacities in various pathologies.
authors: Laboratory of Blood Protective Systems, Biological Faculty, M. V. Lomonosov State Moscow University, Russia. mgrigorjeva@mail.ru
authors: M E
authors: ME
authors: Grigorjeva
authors: M Kh
authors: MKh
authors: Kazancheva
authors: L A
authors: LA
authors: Lyapina
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D021461:Animals, Outbred Strains; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005342:Fibrinolysis / Q000187:drug effects; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000925:Anticoagulants; C572888:Arg-Pro-Gly-Pro; D009842:Oligopeptides