title: Synthesis and characterization of superparamagnetic CoFe2O4/MWCNT hybrids for tumor-targeted therapy.
abstract: Owing to their great potentialities of carbon nanotubes (CNTs)-based magnetic nano-composites, numerous applications of them have been found in nanotechnology, integrated functional system, and in medicine. Herein, nearly monodisperse CoFe2O4 nanoparticles have been deposited on multi-walled carbon nanotubes (MWCNTs) by high-temperature hydrolysis and inorganic polymerization of ionic Co(II) and Fe(III) salts and MWCNTs in a polyol solution. X-ray diffraction, energy-dispersive X-ray spectrometry and transmission electron microscopy were used to characterize the final products. The average size of CoFe2O4 nanoparticles and their coverage density on MWCNTs can be adjusted to some extent by altering the reaction parameters. A proposed formation mechanism of the magnetic hybrids is presented. Magnetic measurements showed that the hybrids were superparamagnetic at room temperature and their saturation magnetization could be fine tuned by changing the loading of CoFe2O4 nanoparticles on the MWCNTs.
authors: Department of Urology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
authors: Chuanyu
authors: C
authors: Sun
authors: Yong
authors: Y
authors: Liu
authors: Weihong
authors: W
authors: Ding
authors: Yuancheng
authors: Y
authors: Gou
authors: Ke
authors: K
authors: Xu
authors: Guowei
authors: G
authors: Xia
authors: Qiang
authors: Q
authors: Ding
mesh_terms: D000818:Animals; D003035:Cobalt / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D046911:Macromolecular Substances / Q000737:chemistry; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D008422:Materials Testing; D008968:Molecular Conformation; D053769:Nanocapsules / Q000737:chemistry / Q000627:therapeutic use / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure*; D009369:Neoplasms / Q000188:drug therapy; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties
chemical_list: D005290:Ferric Compounds; D046911:Macromolecular Substances; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D037742:Nanotubes, Carbon; D010087:Oxides; C000499:ferric oxide; D003035:Cobalt; C060728:cobalt oxide