title: A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases.
abstract: We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53. A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation. This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.
authors: Department of Otolaryngology Head and Neck Surgery, The University of Western Ontario, Victoria Hospital, London Health Science Centre, Room B3-431A, 800 Commissioners Road East, London, ON, Canada.
authors: Anthony C
authors: AC
authors: Nichols
authors: Michelle
authors: M
authors: Chan-Seng-Yue
authors: John
authors: J
authors: Yoo
authors: Sumit K
authors: SK
authors: Agrawal
authors: Maud H W
authors: MH
authors: Starmans
authors: Daryl
authors: D
authors: Waggott
authors: Nicholas J
authors: NJ
authors: Harding
authors: Samuel A
authors: SA
authors: Dowthwaite
authors: David A
authors: DA
authors: Palma
authors: Kevin
authors: K
authors: Fung
authors: Bret
authors: B
authors: Wehrli
authors: S Danielle
authors: SD
authors: Macneil
authors: Philippe
authors: P
authors: Lambin
authors: Eric
authors: E
authors: Winquist
authors: James
authors: J
authors: Koropatnick
authors: Joe S
authors: JS
authors: Mymryk
authors: Paul C
authors: PC
authors: Boutros
authors: John W
authors: JW
authors: Barrett
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