title: Mitochondrial ROS in the prohypertensive immune response.
abstract: In the past decade, it has become clear that reactive oxygen species (ROS) and inflammation play an important role in the development of hypertension. Scavenging of mitochondrial superoxide and blocking either IL-17 or tumor necrosis factor-α (TNF-α) attenuates hypertension. T-cells, critical for development of hypertension, once activated intensively produce cytokines, proliferate, and differentiate. Thus T-cell activation leads to expanded energy demand. To fulfill these needs, T-cells through tightly regulated mechanisms, supported by mitochondrial ROS (mtROS), alter their metabolic phenotype. In this review we summarize data and show evidence supporting new concept that mtROS directly contributes to prohypertensive response of immune cells.
authors: Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37212, USA. r.nazar@Vanderbilt.edu
authors: Rafal R
authors: RR
authors: Nazarewicz
authors: Sergey I
authors: SI
authors: Dikalov
mesh_terms: D000818:Animals; D006801:Humans; D006973:Hypertension / Q000276:immunology / Q000378:metabolism*; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism; D008928:Mitochondria / Q000276:immunology / Q000378:metabolism*; D018384:Oxidative Stress / Q000276:immunology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D020381:Interleukin-17; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha
keywords: T cells; hypertension; immune cell activation; mitochondrial ROS; superoxide
references: Hypertension. 2009 Aug;54(2):338-44
references: 19506101
references: Antioxid Redox Signal. 2013 Aug 1;19(4):344-9
references: 23373855
references: Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1604-12
references: 23564345
references: Biochim Biophys Acta. 2012 May;1823(5):1041-52
references: 22429591
references: PLoS One. 2012;7(10):e38388
references: 23144690
references: Circ Res. 2010 Jul 9;107(1):106-16
references: 20448215
references: Immunol Rev. 2012 Sep;249(1):104-15
references: 22889218
references: Immunity. 2011 Dec 23;35(6):871-82
references: 22195744
references: Cell Rep. 2012 Nov 29;2(5):1300-15
references: 23168256
references: Am J Physiol Regul Integr Comp Physiol. 2012 May 15;302(10):R1134-42
references: 22442197
references: Immunity. 2013 Feb 21;38(2):225-36
references: 23415911
references: J Am Soc Hypertens. 2013 Jan-Feb;7(1):68-74
references: 23321405
references: Front Physiol. 2012 May 07;3:128
references: 22586409