title: Nanoceria-triggered synergetic drug release based on CeO(2) -capped mesoporous silica host-guest interactions and switchable enzymatic activity and cellular effects of CeO(2).
abstract: Herein, a pH stimuli-responsive vehicle for intracellular drug delivery using CeO2 capped mesoporous silica nanoparticles (MSN) is reported. β-Cyclodextrin-modified CeO2 nanoparticles could cap onto ferrocene-functionalized mesoporous silica through host-guest interactions. After internalization into A549 cells by a lysosomal pathway, the ferrocenyl moieties are oxidized to ferrocenium ions by CeO2 lids, which could trigger the uncapping of the CeO2 and cause the drugs release. Because of the pH-dependent toxicity, the CeO2 here behaves as a multi-purpose entity that not only acts as a lid but also exhibits a synergistic antitumor effect on cancer cells. Meanwhile, the cell protective effect of CeO2 nanoparticles alone is demonstrated, which ensures that the dissolved CeO2 nanoparticles can be non-toxic to normal cells.
authors: Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: (+ 86) 431-85262656.
authors: Can
authors: C
authors: Xu
authors: Youhui
authors: Y
authors: Lin
authors: Jiasi
authors: J
authors: Wang
authors: Li
authors: L
authors: Wu
authors: Weili
authors: W
authors: Wei
authors: Jinsong
authors: J
authors: Ren
authors: Xiaogang
authors: X
authors: Qu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002563:Cerium / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D004357:Drug Synergism; D005296:Ferrous Compounds / Q000737:chemistry / Q000493:pharmacokinetics; D057809:HEK293 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D042541:Intracellular Space / Q000737:chemistry / Q000378:metabolism; D000075163:Metallocenes; D053758:Nanoparticles / Q000737:chemistry*; D011312:Pressure; D012822:Silicon Dioxide / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005296:Ferrous Compounds; D000075163:Metallocenes; D002563:Cerium; C030583:ceric oxide; D012822:Silicon Dioxide; C004998:ferrocene
keywords: cerium oxide; drug delivery; host-guest interaction; mesoporous silica nanoparticles; β-cyclodextirn