title: Polypeptoids by living ring-opening polymerization of N-substituted N-carboxyanhydrides from solid supports.
abstract: The nucleophilic living ring-opening polymerization of N-substituted glycine N-carboxyanhydrides using solid-phase synthesis resins is reported. By variation of experimental parameters, products with near Poisson distributions are obtained. As opposed to reversible deactivation radical polymerization, the living polymerization is demonstrated to be viable to high monomer conversion and through multiple monomer addition steps. Successful preparation of a multiblock copolypeptoid is proof for a highly living and robust character of the solid-phase peptoid polymerization.
authors: Department Chemie und Lebensmittelchemie, Technische Universität Dresden, 01062 Dresden, Germany.
authors: Niklas
authors: N
authors: Gangloff
authors: Corinna
authors: C
authors: Fetsch
authors: Robert
authors: R
authors: Luxenhofer
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D015394:Molecular Structure; D034444:Peptoids / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques
chemical_list: D000812:Anhydrides; D034444:Peptoids; D011108:Polymers