title: Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro.
abstract: Sarcopenia is characterized by the age-related loss of muscle mass and strength. One of the mechanisms of sarcopenia is the loss in the function and number of muscle satellite cells. Royal jelly (RJ) is a health food used worldwide. To obtain better digestion and absorption than RJ, protease-treated RJ (pRJ) has been developed. RJ and pRJ have been suggested to have potential pharmacological benefits such as prolonging the life span and reducing fatigue. Because these effects may improve sarcopenia and the functions of satellite cells, we examined the effects of RJ or pRJ treatment on the skeletal muscles in an animal model using aged mice. In vivo, RJ/pRJ treatment attenuated the decrease in the muscle weight and grip strength and increased the regenerating capacity of injured muscles and the serum insulin-like growth factor-1 levels compared with controls. In vitro, using isolated satellite cells from aged mice, pRJ treatment increased the cell proliferation rate, promoted cell differentiation, and activated Akt intracellular signaling pathway compared with controls. These findings suggest that RJ/pRJ treatment had a beneficial effect on age-related sarcopenia.
authors: Lab of Nutritional Epidemiology, Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, 300070 Tianjin, People's Republic of China. nkj0809@gmail.com.
authors: Kaijun
authors: K
authors: Niu
authors: Hui
authors: H
authors: Guo
authors: Yinting
authors: Y
authors: Guo
authors: Satoru
authors: S
authors: Ebihara
authors: Masanori
authors: M
authors: Asada
authors: Takashi
authors: T
authors: Ohrui
authors: Katsutoshi
authors: K
authors: Furukawa
authors: Masakazu
authors: M
authors: Ichinose
authors: Kazuhiko
authors: K
authors: Yanai
authors: Yukitsuka
authors: Y
authors: Kudo
authors: Hiroyuki
authors: H
authors: Arai
authors: Tatsuma
authors: T
authors: Okazaki
authors: Ryoichi
authors: R
authors: Nagatomi
mesh_terms: D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D016922:Cellular Senescence / Q000187:drug effects; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D051379:Mice; D053580:Muscle Strength / Q000187:drug effects; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D055948:Sarcopenia / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control; D032496:Satellite Cells, Skeletal Muscle / Q000187:drug effects / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D016896:Treatment Outcome; D000099219:Royal Jelly
chemical_list: D005227:Fatty Acids; D007334:Insulin-Like Growth Factor I; D051057:Proto-Oncogene Proteins c-akt; D000099219:Royal Jelly
keywords: Aged mice; Akt signaling.; Insulin-like growth factor-1; Royal jelly; Sarcopenia; Satellite cells