title: Transduction of voltage and Ca2+ signals by Slo1 BK channels.
abstract: Large-conductance Ca2+ -and voltage-gated K+ channels are activated by an increase in intracellular Ca2+ concentration and/or depolarization. The channel activation mechanism is well described by an allosteric model encompassing the gate, voltage sensors, and Ca2+ sensors, and the model is an excellent framework to understand the influences of auxiliary β and γ subunits and regulatory factors such as Mg2+. Recent advances permit elucidation of structural correlates of the biophysical mechanism.
authors: Department of Physiology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: T
authors: T
authors: Hoshi
authors: A
authors: A
authors: Pantazis
authors: R
authors: R
authors: Olcese
mesh_terms: D000818:Animals; D001665:Binding Sites; D020013:Calcium Signaling; D006801:Humans; D015640:Ion Channel Gating; D051037:Large-Conductance Calcium-Activated Potassium Channel alpha Subunits / Q000737:chemistry / Q000378:metabolism*; D008564:Membrane Potentials; D008954:Models, Biological; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: C494841:KCNMA1 protein, human; D051037:Large-Conductance Calcium-Activated Potassium Channel alpha Subunits
references: EMBO J. 2004 Jun 2;23(11):2196-205
references: 15141163
references: J Gen Physiol. 2013 Jan;141(1):11-28
references: 23250866
references: J Neurosci. 2002 Mar 1;22(5):1550-61
references: 11880485
references: J Neurophysiol. 2006 May;95(5):2878-88
references: 16436475
references: J Gen Physiol. 2012 Aug;140(2):207-18
references: 22802360
references: J Gen Physiol. 2006 Mar;127(3):309-28
references: 16505150
references: Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12161-6
references: 21730134
references: J Gen Physiol. 2013 Jan;141(1):29-60
references: 23250867
references: Nature. 2010 Jul 15;466(7304):393-7
references: 20574420
references: J Biol Chem. 2012 Jun 22;287(26):21741-50
references: 22556415
references: J Gen Physiol. 2013 Feb;141(2):151-60
references: 23319730
references: J Biol Chem. 2010 Feb 26;285(9):6434-42
references: 20037152
references: Nature. 2002 May 30;417(6888):515-22
references: 12037559
references: J Gen Physiol. 2004 Oct;124(4):357-70
references: 15452197
references: BMC Med Genomics. 2011 Jun 28;4:51
references: 21708048
references: Nat Rev Neurosci. 2006 Dec;7(12):921-31
references: 17115074
references: J Neurosci. 2000 May 15;20(10):3563-70
references: 10804197
references: Neuron. 2001 Sep 27;31(6):1015-25
references: 11580900
references: Biophys J. 1997 Sep;73(3):1355-63
references: 9284303
references: Neuron. 1989 Jan;2(1):1031-41
references: 2624739
references: Nature. 2002 Aug 22;418(6900):876-80
references: 12192410
references: J Gen Physiol. 2000 Jul 1;116(1):75-99
references: 10871641
references: J Gen Physiol. 1998 Feb;111(2):313-42
references: 9450946
references: J Gen Physiol. 1999 Mar;113(3):425-40
references: 10051518
references: Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4459-64
references: 20160086
references: Am J Physiol Cell Physiol. 2001 Dec;281(6):C1769-75
references: 11698234
references: Annu Rev Cell Dev Biol. 2006;22:23-52
references: 16704338
references: Channels (Austin). 2009 Jul-Aug;3(4):249-58
references: 19617704
references: J Gen Physiol. 2013 Jan;141(1):105-17
references: 23277477
references: J Biol Chem. 2011 Jun 10;286(23):20701-9
references: 21471215
references: Nature. 2002 Aug 22;418(6900):880-4
references: 12192411
references: J Gen Physiol. 1999 Jul;114(1):93-124
references: 10398695
references: Pflugers Arch. 1994 Mar;426(5):440-5
references: 7517033
references: J Gen Physiol. 2002 Sep;120(3):267-305
references: 12198087
references: Neuron. 1998 Mar;20(3):565-73
references: 9539129
references: J Gen Physiol. 1989 Dec;94(6):1037-70
references: 2614371
references: J Gen Physiol. 1997 Sep;110(3):257-81
references: 9276753
references: J Gen Physiol. 2006 Sep;128(3):347-64
references: 16940557
references: J Neurosci Res. 2011 Nov;89(11):1747-60
references: 21800349
references: Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19419-24
references: 22084117
references: Nature. 2009 Sep 10;461(7261):292-5
references: 19718020
references: Nature. 2000 Feb 17;403(6771):773-6
references: 10693806
references: Annu Rev Physiol. 2009;71:19-36
references: 18694345
references: Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18991-6
references: 23112204
references: J Physiol. 2005 Sep 1;567(Pt 2):545-56
references: 16020453
references: Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10488-93
references: 12925732
references: J Gen Physiol. 2005 Apr;125(4):395-411
references: 15767297
references: J Gen Physiol. 2011 Dec;138(6):593-607
references: 22124117
references: Prog Biophys Mol Biol. 2006 Oct;92(2):185-208
references: 16316679
references: J Gen Physiol. 2005 Jul;126(1):7-21
references: 15955873
references: J Physiol. 1983 Nov;344:585-604
references: 6317853
references: Mol Pharmacol. 2012 Jan;81(1):21-30
references: 21984254
references: J Gen Physiol. 2011 Aug;138(2):137-54
references: 21746846
references: J Gen Physiol. 2008 Jun;131(6):537-48
references: 18474637
references: Annu Rev Biophys. 2012;41:585-609
references: 22577828
references: Trends Cell Biol. 2001 Sep;11(9):353-8
references: 11514177
references: Nature. 2008 Dec 18;456(7224):891-7
references: 19092925
references: Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4776-81
references: 11274367
references: J Physiol. 1999 Nov 15;521 Pt 1:135-46
references: 10562340
references: Trends Pharmacol Sci. 2001 Oct;22(10):505-12
references: 11583807
references: J Neurosci. 2010 Dec 1;30(48):16170-9
references: 21123563
references: Nat Rev Neurosci. 2005 Jun;6(6):449-62
references: 15891778
references: J Biol Chem. 1998 Feb 6;273(6):3509-16
references: 9452476
references: Nature. 2000 Oct 19;407(6806):870-6
references: 11057658
references: Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18700-5
references: 20937866
references: Kidney Int. 2010 Nov;78(10):963-74
references: 20861815
references: Proc Natl Acad Sci U S A. 2012 May 15;109(20):7917-22
references: 22547800
references: Curr Med Chem. 2008;15(11):1126-46
references: 18473808
references: Neuroscience. 2012 Sep 6;219:204-13
references: 22704965
references: J Gen Physiol. 2008 Nov;132(5):491-505
references: 18955592
references: J Gen Physiol. 2006 Apr;127(4):449-65
references: 16567466
references: Magnes Trace Elem. 1991-1992;10(2-4):122-35
references: 1844545
references: Mol Pharmacol. 2013 Jan;83(1):235-44
references: 23093494
references: J Gen Physiol. 2006 Jan;127(1):35-49
references: 16344323
references: Nature. 1981 Oct 8;293(5832):471-4
references: 6273730
references: J Hypertens. 2002 May;20(5):927-33
references: 12011654
references: J Gen Physiol. 1999 Aug;114(2):305-36
references: 10436004
references: Nat Struct Mol Biol. 2008 Apr;15(4):403-10
references: 18345016
references: Neuron. 1995 Jun;14(6):1293-301
references: 7605638
references: Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):376-81
references: 18162557
references: J Gen Physiol. 2007 Jul;130(1):71-81
references: 17591986
references: Biophys J. 2006 Oct 15;91(8):2892-900
references: 16877509
references: Neuron. 2011 Dec 8;72(5):713-20
references: 22153369
references: Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R766-72
references: 16223848
references: J Gen Physiol. 2006 Jun;127(6):755-66
references: 16735758
references: J Physiol. 1997 Aug 1;502 ( Pt 3):545-57
references: 9279807
references: Nature. 2010 Jul 22;466(7305):513-6
references: 20613726
references: J Gen Physiol. 2008 Jan;131(1):13-32
references: 18166624
references: J Gen Physiol. 2010 Aug;136(2):189-202
references: 20624858
references: Neuron. 2001 Jun;30(3):689-98
references: 11430803
references: J Gen Physiol. 2005 Mar;125(3):273-86
references: 15738049
references: J Gen Physiol. 2004 May;123(5):475-89
references: 15111643
references: Nature. 2012 May 3;485(7396):133-6
references: 22522931
references: Alcohol Clin Exp Res. 2006 May;30(5):745-53
references: 16634842
references: Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19813-8
references: 18077413
references: Science. 1995 Oct 27;270(5236):633-7
references: 7570021
references: Biophys J. 2008 Jun;94(12):4678-87
references: 18339745
references: FEBS Lett. 2012 Jul 30;586(16):2287-93
references: 22710124
references: Neuron. 1995 Mar;14(3):645-50
references: 7695911
references: J Gen Physiol. 2006 Feb;127(2):191-204
references: 16446507
references: Physiol Rev. 2010 Oct;90(4):1437-59
references: 20959620
references: J Biol Chem. 1994 Sep 16;269(37):23336-41
references: 7521879
references: Naunyn Schmiedebergs Arch Pharmacol. 2007 Nov;376(3):145-55
references: 17932654
references: J Gen Physiol. 1995 Feb;105(2):209-26
references: 7760017
references: J Gen Physiol. 2001 Nov;118(5):589-606
references: 11696614
references: Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20790-5
references: 22084100
references: J Gen Physiol. 2007 Mar;129(3):209-20
references: 17296928
references: J Physiol. 1991 Nov;443:739-77
references: 1822543
references: Biophys J. 2003 May;84(5):2969-80
references: 12719228
references: J Physiol. 2007 May 1;580(Pt.3):859-82
references: 17303637
references: Science. 2012 Apr 13;336(6078):229-33
references: 22499946
references: Science. 2010 Jul 9;329(5988):182-6
references: 20508092
references: J Biol Chem. 2000 Mar 3;275(9):6453-61
references: 10692449
references: J Gen Physiol. 2009 Feb;133(2):139-50
references: 19139175
references: J Membr Biol. 2005 Dec;208(3):229-40
references: 16604468
references: Nat Neurosci. 2006 Aug;9(8):1041-9
references: 16845385
references: Eur J Pharmacol. 2005 May 9;514(2-3):111-9
references: 15910797
references: Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11413-8
references: 22733762
references: Nat Neurosci. 2006 Nov;9(11):1397-1403
references: 17013381
references: Science. 1999 Sep 17;285(5435):1929-31
references: 10489376
references: Nat Genet. 2005 Jul;37(7):733-8
references: 15937479
references: J Clin Invest. 2003 Sep;112(5):717-24
references: 12952920
references: Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14066-71
references: 9391153
references: J Gen Physiol. 1985 Nov;86(5):601-11
references: 2415669
references: J Gen Physiol. 2010 Dec;136(6):645-57
references: 21078868
references: Biophys Struct Mech. 1982;9(1):35-60
references: 6293598
references: J Physiol. 2005 Nov 15;569(Pt 1):137-51
references: 16150795
references: Science. 2003 Nov 21;302(5649):1416-8
references: 14631046
references: Nat Neurosci. 2005 Dec;8(12):1752-9
references: 16261134
references: J Neurosci. 2001 Dec 15;21(24):9585-97
references: 11739569
references: Nature. 2003 Oct 2;425(6957):531-5
references: 14523450
references: J Mol Microbiol Biotechnol. 1999 Nov;1(2):281-7
references: 10943557
references: Biophys J. 1994 Jul;67(1):91-104
references: 7919030
references: Alcohol. 1993 Nov-Dec;10(6):563-6
references: 8123219
references: Science. 2006 Oct 27;314(5799):615-20
references: 17068255
references: J Neurosci. 2007 Jan 17;27(3):483-95
references: 17234581
references: J Gen Physiol. 1997 May;109(5):647-73
references: 9154910
references: Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19096-101
references: 20959415
references: J Gen Physiol. 2010 Sep;136(3):283-91
references: 20713546
references: J Neurosci. 2000 Jul 1;20(13):4890-903
references: 10864947
references: J Gen Physiol. 2007 Jul;130(1):117-31
references: 17591990
references: Nat Neurosci. 2006 Jan;9(1):41-9
references: 16341213
references: Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18270-5
references: 17984060
references: J Gen Physiol. 2012 Mar;139(3):235-44
references: 22371364
references: Channels (Austin). 2010 Jan-Feb;4(1):22-41
references: 19934650
references: J Gen Physiol. 2012 Jan;139(1):57-67
references: 22155735
references: J Gen Physiol. 2001 Jun;117(6):607-28
references: 11382809
references: Neuron. 2001 Mar;29(3):593-601
references: 11301020
references: J Biol Chem. 2005 Dec 16;280(50):41716-24
references: 16227203
references: Neuron. 1997 Nov;19(5):1127-40
references: 9390525
references: J Physiol. 2009 Apr 1;587(Pt 7):1481-98
references: 19204046
references: J Gen Physiol. 2005 Oct;126(4):393-412
references: 16186565
references: Sci STKE. 2004 Mar 30;2004(227):pe16
references: 15069208
references: J Gen Physiol. 2002 Jul;120(1):15-27
references: 12084772
references: Biochemistry. 2000 Dec 19;39(50):15612-9
references: 11112549
references: Nature. 2011 Dec 04;481(7379):94-7
references: 22139424
references: Kidney Int. 2010 Nov;78(10):956-62
references: 20720523
references: Proc Natl Acad Sci U S A. 2000 May 9;97(10):5562-7
references: 10792058
references: Neuron. 1992 Aug;9(2):209-16
references: 1497890
references: J Gen Physiol. 2008 Jul;132(1):13-28
references: 18562499
references: Nature. 1998 Oct 29;395(6705):900-5
references: 9804423
references: J Gen Physiol. 2002 Dec;120(6):829-43
references: 12451052
references: J Gen Physiol. 2012 Dec;140(6):625-34
references: 23183698
references: FEBS Lett. 2000 May 26;474(1):99-106
references: 10828459
references: Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5096-101
references: 16549765
references: J Physiol. 2004 Jan 15;554(Pt 2):255-61
references: 14500775
references: J Clin Invest. 2004 Apr;113(7):955-7
references: 15057299
references: J Biol Chem. 2000 Jul 28;275(30):23211-8
references: 10766764
references: Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14922-7
references: 8962157
references: J Biol Chem. 1994 Feb 11;269(6):3921-4
references: 7508434
references: Proc Natl Acad Sci U S A. 1997 May 13;94(10):5427-31
references: 9144254
references: J Neurosci. 2009 Jul 1;29(26):8321-8
references: 19571123
references: Hum Mol Genet. 2008 Sep 1;17(17):2681-90
references: 18535015
references: J Physiol. 1988 Aug;402:79-120
references: 3236256
references: J Biol Chem. 2009 Aug 28;284(35):23353-63
references: 19561088
references: Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4137-42
references: 10097176
references: Nature. 2007 Nov 15;450(7168):376-82
references: 18004376
references: Neuron. 2008 Feb 7;57(3):345-51
references: 18255028
references: J Gen Physiol. 2006 Oct;128(4):389-404
references: 17001085
references: J Neurosci. 1999 Jul 1;19(13):5255-64
references: 10377337
references: J Gen Physiol. 2002 Aug;120(2):173-89
references: 12149279
references: Nat Struct Mol Biol. 2009 Jul;16(7):704-10
references: 19561608
references: J Gen Physiol. 1999 Aug;114(2):277-304
references: 10436003
references: Nat Rev Mol Cell Biol. 2008 Apr;9(4):323-32
references: 18354422
references: Nat Struct Mol Biol. 2008 Nov;15(11):1152-9
references: 18931675
references: Neurobiol Dis. 2005 Nov;20(2):296-302
references: 16242636
references: Science. 2010 Apr 2;328(5974):67-73
references: 20360102
references: J Gen Physiol. 2010 May;135(5):449-59
references: 20385746
references: J Gen Physiol. 1994 Feb;103(2):321-62
references: 8189208
references: J Biol Chem. 2004 Aug 27;279(35):36445-53
references: 15210719
references: Nature. 1984 Feb 23-29;307(5953):693-6
references: 6321995
references: J Physiol. 1982 Oct;331:211-30
references: 6296366
references: Neuron. 2004 Jun 10;42(5):745-56
references: 15182715
references: J Gen Physiol. 2001 Nov;118(5):607-36
references: 11696615