title: CMV driven CD8(+) T-cell activation is associated with acute rejection in lung transplantation.
abstract: Lung transplantation is the definitive treatment for terminal respiratory disease, but the associated mortality rate is high. Acute rejection of the transplanted lung is a key determinant of adverse prognosis. Furthermore, an epidemiological relationship has been established between the occurrence of acute lung rejection and cytomegalovirus infection. However, the reasons for this association remain unclear. Here, we performed a longitudinal characterization of CMV-specific T-cell responses and immune activation status in the peripheral blood and bronchoalveolar lavage fluid of forty-four lung transplant patients. Acute rejection was associated with high levels of cellular activation in the periphery, reflecting strong CMV-specific CD8(+) T-cell activity post-transplant. Peripheral and lung CMV-specific CD8(+) T-cell responses were very similar, and related to the presence of CMV in the transplanted organ. These findings support that activated CMV-specific CD8(+) T-cells in the lung may play a role in promoting acute rejection.
authors: INSERM UMR S 945, Infections and Immunity, Université Pierre et Marie Curie-Paris6, Hôpital Pitié-Salpêtrière, 75013 Paris, France. a.roux@hopital-foch.org
authors: Antoine
authors: A
authors: Roux
authors: Gisèle
authors: G
authors: Mourin
authors: Solène
authors: S
authors: Fastenackels
authors: Jorge R
authors: JR
authors: Almeida
authors: Maria Candela
authors: MC
authors: Iglesias
authors: Anders
authors: A
authors: Boyd
authors: Emma
authors: E
authors: Gostick
authors: Martin
authors: M
authors: Larsen
authors: David A
authors: DA
authors: Price
authors: Karim
authors: K
authors: Sacre
authors: Daniel C
authors: DC
authors: Douek
authors: Brigitte
authors: B
authors: Autran
authors: Clément
authors: C
authors: Picard
authors: Sandra de
authors: Sd
authors: Miranda
authors: Delphine
authors: D
authors: Sauce
authors: Marc
authors: M
authors: Stern
authors: Victor
authors: V
authors: Appay
mesh_terms: D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000821:virology; D005260:Female; D005434:Flow Cytometry; D006084:Graft Rejection / Q000276:immunology* / Q000821:virology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008137:Longitudinal Studies; D016040:Lung Transplantation / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018709:Statistics, Nonparametric