title: Surgery for metastatic disease.
abstract: OBJECTIVE
  Outcomes for children with cancer have steadily improved and the long-term survival for most early-stage childhood malignancies is now greater than 90%. On the contrary, the prognosis for children with metastatic cancer, though significantly improved from a generation ago, is generally still very disappointing. Surgery continues to play a role in the increasingly aggressive treatment of children with metastatic disease with the ultimate goal of prolonging survival and improving quality of life.
  
  
  RESULTS
  Most childhood tumors are relatively rare and are therefore studied using a multi-institutional cooperative group model that standardizes protocols and pools resources and data, accounting for the remarkable progress that has been made in the care of children with cancer. In some cases, this has also allowed us to recognize the utility of certain surgical therapies and the need to further study others.
  
  
  CONCLUSIONS
  Modern surgery and critical care allow us to consider offering children with metastatic disease more aggressive surgical options in circumstances where the data suggest the potential for long-term survival. In situations where data are lacking, children might be offered a surgical option as part of an ongoing trial.
authors: Department of Surgery, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA. mattei@chop.edu
authors: Peter
authors: P
authors: Mattei
mesh_terms: D002648:Child; D018197:Hepatoblastoma / Q000556:secondary / Q000601:surgery; D006801:Humans; D007680:Kidney Neoplasms; D008113:Liver Neoplasms; D059146:Metastasectomy / Q000379:methods*; D009447:Neuroblastoma / Q000556:secondary / Q000601:surgery; D011379:Prognosis; D012509:Sarcoma / Q000556:secondary / Q000601:surgery; D021701:Sentinel Lymph Node Biopsy; D009396:Wilms Tumor / Q000556:secondary / Q000601:surgery