title: C-arm CT for histomorphometric evaluation of lumbar spine trabecular microarchitecture: a study on anorexia nervosa patients.
abstract: Bone histomorphometry measurements require high spatial resolution that may not be feasible using multidetector CT (MDCT). This study evaluated the trabecular microarchitecture of lumbar spine using MDCT and C-arm CT in a series of young adult patients with anorexia nervosa (AN). 11 young females with AN underwent MDCT (anisotropic resolution with a slice thickness of ~626 μm) and C-arm CT (isotropic resolution of ~200 µm). Standard histomorphometric parameters the of L1 vertebral body, namely the apparent trabecular bone volume fraction (BV/TV), trabecular thickness (TbTh), trabecular number (TbN) and trabecular separation (TbSp), were analysed using MicroView software (GE Healthcare, Piscataway, NJ). Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry. Trabecular parameters derived from MDCT and C-arm CT were compared, and their association with BMD parameters was evaluated. Histomorphometric parameters derived from C-arm CT, namely TbTh, TbN and TbSp, were significantly different from the corresponding MDCT parameters. There were no significant correlations between C-arm CT-derived parameters and the corresponding MDCT-derived parameters. C-arm CT-derived parameters were significantly (p<0.001) correlated with anteroposterior L1 spine BMD and Z-scores: TbTh (r=0.723, r=0.744, respectively), TbN (r=-0.720, r=-0.712, respectively) and TbSp (r=0.656, r=0.648, respectively). BV/TV, derived from C-arm CT, was significantly associated with body mass index (r=0.636) and ideal body weight (r=0.730) (p<0.05). These associations were not present in MDCT-derived parameters. This study suggests that the spatial resolution offered by C-arm CT more accurately captures the histomorphometric parameters of trabecular morphology than MDCT in patients with AN.
authors: Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors: C M
authors: CM
authors: Phan
authors: O
authors: O
authors: Khalilzadeh
authors: J
authors: J
authors: Dinkel
authors: I S
authors: IS
authors: Wang
authors: M A
authors: MA
authors: Bredella
authors: M
authors: M
authors: Misra
authors: K K
authors: KK
authors: Miller
authors: A
authors: A
authors: Klibanski
authors: R
authors: R
authors: Gupta
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000856:Anorexia Nervosa / Q000000981:diagnostic imaging / Q000473:pathology*; D015519:Bone Density / Q000502:physiology; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000648:ultrastructure; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*; D055114:X-Ray Microtomography / Q000379:methods; D055815:Young Adult
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