title: Plasma leptin level predicts hematoma growth and early neurological deterioration after acute intracerebral hemorrhage.
abstract: Higher plasma leptin levels have been associated with poor clinical outcomes after intracerebral hemorrhage. Nevertheless, their links with hematoma growth and early neurological deterioration are unknown. Therefore, we aimed to investigate the relationship between plasma leptin levels, hematoma growth, and early neurological deterioration in patients with acute intracerebral hemorrhage. We prospectively studied 102 consecutive patients with acute spontaneous basal ganglia hemorrhage presenting within 6h from symptoms onset. Significant hematoma growth was defined as hematoma enlargement >33% at 24h. Early neurological deterioration was defined as an increase of ≥4 points in National Institute of Health Stroke Scale score at 24h from symptoms onset. We measured plasma leptin levels on admission using an enzyme-linked immunosorbent assay in a blinded fashion. In multivariate logistic regression analysis, plasma leptin level emerged as the independent predictor of hematoma growth (odds ratio, 1.182; 95% confidence interval, 1.061-2.598; P=0.008) and early neurological deterioration (odds ratio, 1.193; 95% confidence interval, 1.075-2.873; P=0.004). Using receiver operating characteristic curves, we calculated areas under the curve for hematoma growth (area under curve, 0.844; 95% confidence interval, 0.759-0.908) and early neurological deterioration (area under curve, 0.857; 95% confidence interval, 0.774-0.918). The predictive performance of leptin was similar to, but did not obviously improve that of hematoma volume. Thus, leptin may help in the prediction of hematoma growth and early neurological deterioration after intracerebral hemorrhage.
authors: Department of Neurosurgery, The First People's Hospital of Hangzhou, Nanjing Medical University, 261 Huansha Road, Hangzhou 310006, China.
authors: Quan
authors: Q
authors: Du
authors: Ding-Bo
authors: DB
authors: Yang
authors: Yong-Feng
authors: YF
authors: Shen
authors: Wen-Hua
authors: WH
authors: Yu
authors: Zu-Yong
authors: ZY
authors: Zhang
authors: Qiang
authors: Q
authors: Zhu
authors: Zhi-Hao
authors: ZH
authors: Che
authors: Qun-Jie
authors: QJ
authors: Liu
authors: Hao
authors: H
authors: Wang
authors: Xiao-Qiao
authors: XQ
authors: Dong
mesh_terms: D000368:Aged; D019540:Area Under Curve; D020145:Basal Ganglia Hemorrhage / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006406:Hematoma / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D020738:Leptin / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D020738:Leptin