title: Functional similarity between E6 proteins of cutaneous human papillomaviruses and the adenovirus E1A tumor-restraining module.
abstract: The adenovirus E1A C-terminal region restrains oncogenic transformation through interaction with three distinct cellular protein complexes that include the DYRK1A/1B/HAN11 complex. The E6 proteins of beta-human papillomaviruses (beta-HPVs) also interact with the DYRK1/HAN11 complex. A variant of HPV5 E6 frequently found in epidermodysplasia verruciformis skin lesions interacted less efficiently with DYRK1A/HAN11. The E6 variant and E7 of HPV5 efficiently coimmortalized primary epithelial cells, suggesting that naturally arising variants may contribute potential oncogenic activities of beta-HPV E6 proteins.
authors: Institute for Molecular Virology, Saint Louis University School of Medicine, Doisy Research Center, St. Louis, Missouri, USA.
authors: Mohan
authors: M
authors: Kuppuswamy
authors: T
authors: T
authors: Subramanian
authors: Elizabeth
authors: E
authors: Kostas-Polston
authors: S
authors: S
authors: Vijayalingam
authors: Ling-jun
authors: LJ
authors: Zhao
authors: Mark
authors: M
authors: Varvares
authors: G
authors: G
authors: Chinnadurai
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D017500:Adenovirus E1A Proteins / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D052686:Betapapillomavirus / Q000378:metabolism*; D015153:Blotting, Western; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D006801:Humans; D047468:Immunoprecipitation; D008969:Molecular Sequence Data; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D017385:Sequence Homology; D014779:Virus Replication / Q000235:genetics; D000097603:Dyrk Kinases
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D017500:Adenovirus E1A Proteins; D046912:Multiprotein Complexes; D009856:Oncogene Proteins, Viral; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D000097603:Dyrk Kinases; C515143:DCAF7 protein, human; C487708:E6 protein, human papillomavirus type 5
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