title: Microfluidic large scale integration of viral-host interaction analysis.
abstract: Viral-host interactions represent potential drug targets for novel antiviral strategies (Flisiak et al., Hepatology, 2008, 47, 817-26). Hence, it is important to establish an adequate platform for identifying and analyzing such interactions. In this review, we discuss bottlenecks in conventional protein-protein interaction methodologies and present the contribution of innovative microfluidic-based technologies towards a solution to these problems with respect to viral-host proteomics.
authors: The Mina & Everard Goodman Faculty of Life Sciences, The Nanotechnology Institute, Bar-Ilan University, Ramat Gan, Israel.
authors: Ya'ara
authors: Y
authors: Ben-Ari
authors: Yair
authors: Y
authors: Glick
authors: Sarit
authors: S
authors: Kipper
authors: Nika
authors: N
authors: Schwartz
authors: Dorit
authors: D
authors: Avrahami
authors: Efrat
authors: E
authors: Barbiro-Michaely
authors: Doron
authors: D
authors: Gerber
mesh_terms: D016174:Hepacivirus / Q000378:metabolism; D057166:High-Throughput Screening Assays; D054884:Host-Pathogen Interactions; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D060066:Protein Interaction Maps; D011506:Proteins / Q000378:metabolism*; D017361:Viral Nonstructural Proteins / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism; D014780:Viruses / Q000378:metabolism*; D012324:RNA-Dependent RNA Polymerase
chemical_list: D011506:Proteins; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase