title: Reducing the financial impact of pathogen inactivation technology for platelet components: our experience.
abstract: BACKGROUND
  Pathogen inactivation (PI) technology for blood components enhances blood safety by inactivating viruses, bacteria, parasites, and white blood cells. Additionally, PI for platelet (PLT) components has the potential to extend PLT storage time from 5 to 7 days.
  
  
  METHODS
  A retrospective analysis was conducted into the percentage of outdated PLT components during the 3 years before and after the adoption of PLT PI technology in our institution. The PLT transfusion dose for both pre-PI and post-PI periods was similar. A retrospective analysis to study clinical safety and component utilization was also performed in the Balearic Islands University Hospital.
  
  
  RESULTS
  As a result of PI implementation in our institution, the PLT production cost increased by 85.5%. However, due to the extension of PLT storage time, the percentage of outdated PLT units substantially decreased (-83.9%) and, consequently, the cost associated with outdated units (-69.8%). This decrease represented a 13.7% reduction of the initial cost increase which, together with the saving in blood transportation (0.1%), led to a saving of 13.8% over the initial cost. Therefore, the initial 85.5% increase in the cost of PLT production was markedly reduced to 71.7%. The mean number of PLT concentrates per patient was similar during both periods.
  
  
  CONCLUSIONS
  The extension of PLT storage time can substantially contribute to reducing the financial impact of PI by decreasing the percentage of outdated PLTs while improving blood safety. Since the adoption of PI, there have been no documented cases of PLT transfusion-related sepsis in our region.
authors: Fundació Banc de Sang i Teixits de les Illes Balears, Majorca, Spain; Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Majorca, Spain; Son Espases University Hospital, Majorca, Spain.
authors: Enrique
authors: E
authors: Girona-Llobera
authors: Teresa
authors: T
authors: Jimenez-Marco
authors: Ana
authors: A
authors: Galmes-Trueba
authors: Josep
authors: J
authors: Muncunill
authors: Carmen
authors: C
authors: Serret
authors: Neus
authors: N
authors: Serra
authors: Matilde
authors: M
authors: Sedeño
mesh_terms: D001792:Blood Platelets / Q000382:microbiology*; D058731:Blood Safety / Q000191:economics* / Q000379:methods* / Q000706:statistics & numerical data; D017848:Blood-Borne Pathogens; D017046:Cost Savings / Q000379:methods; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008297:Male; D050296:Microbial Viability; D008875:Middle Aged; D017713:Platelet Transfusion / Q000009:adverse effects / Q000379:methods / Q000592:standards; D010983:Plateletpheresis / Q000592:standards / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology