title: Two new neuroprotective phenolic compounds from Gastrodia elata.
abstract: Two new phenolic compounds 4-(4'-hydroxybenzyl) phenyl glucoside (gastrodin B, 1) and 1'-hydroxymethyl-phenyl 4-hydroxy-3-(4″-hydroxybenzyl) benzyl ether (gastrol B, 2) were isolated from the rhizomes of Gastrodia elata. Their structures were elucidated on the basis of spectroscopic data and chemical reaction. All compounds exhibited potent neuroprotective activity against H2O2-induced PC12 cell damage.
authors: School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
authors: Zhen-Chang
authors: ZC
authors: Zhang
authors: Gang
authors: G
authors: Su
authors: Jiong
authors: J
authors: Li
authors: Hua
authors: H
authors: Wu
authors: Xiao-Dong
authors: XD
authors: Xie
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031668:Gastrodia / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010647:Phenyl Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051381:Rats; D027343:Rhizome / Q000737:chemistry
chemical_list: C583106:1'-hydroxymethyl-phenyl 4-hydroxy-3-(4'-hydroxybenzyl) benzyl ether; C583105:4-(4'-hydroxybenzyl)phenyl glucoside; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D018696:Neuroprotective Agents; D010636:Phenols; D010647:Phenyl Ethers; D006861:Hydrogen Peroxide