title: Producing xylan/Eudragit® S100-based microparticles by chemical and physico-mechanical approaches as carriers for 5-aminosalicylic acid.
abstract: Xylan is a biopolymer found in a variety of cell wall plants. Eudragit® S-100 (ES100), a pH-dependent polymer, is used as a coating material in gastroresistant delivery systems. In this study, microparticles based on both polymers were produced by interfacial cross-linking polymerisation and/or spray-drying technique in order to investigate feasibility and stability of the systems. Size and morphology of the microparticles were characterised by optical and SEM while FT-IR, thermal analysis (TG/DTA), and X-ray diffraction (XRD) evaluated the drug-polymer interactions and the thermal behaviour of the systems. FT-IR confirmed the absence of chemical interaction between the polymers. TG/DTA analysis showed a higher stability for spray-dried microparticles and XRD data proved the amorphous feature of both carriers. The results reveal that xylan/ES100 microparticles can be produced by chemical or physico-mechanical ways, the latter being the best option due to the lack of toxic cross-linking agents and easy scale-up.
authors: UFRN - Programa de Pós-graduação em Ciências da Saúde (PPgCSa) - Natal/RN , Brazil .
authors: Acarilia Eduardo
authors: AE
authors: Silva
authors: Elquio Eleamen
authors: EE
authors: Oliveira
authors: Monique C Salgado
authors: MC
authors: Gomes
authors: Henrique Rodrigues
authors: HR
authors: Marcelino
authors: Karen C Holanda
authors: KC
authors: Silva
authors: Bartolomeu Santos
authors: BS
authors: Souza
authors: Toshiyuki
authors: T
authors: Nagashima
authors: Alejandro Pedro
authors: AP
authors: Ayala
authors: Anselmo Gomes
authors: AG
authors: Oliveira
authors: Eryvaldo Sócrates Tabosa
authors: ES
authors: do Egito
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D003890:Desiccation; D004055:Differential Thermal Analysis; D004337:Drug Carriers / Q000737:chemistry*; D019804:Mesalamine / Q000008:administration & dosage*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D014990:Xylans / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D011109:Polymethacrylic Acids; D014990:Xylans; C038300:methylmethacrylate-methacrylic acid copolymer; D019804:Mesalamine