title: [Relationship between glypican-3 and Notch1 expressions in hepatocellular carcinoma].
abstract: OBJECTIVE
  To investigate the correlation between the expressions of glypican-3 (GPC3) and Notch1 and their roles in the tumorigenesis and progression of hepatocellular carcinoma (HCC).
  
  
  METHODS
  Immunohistochemistry and computerized image analysis were utilized to quantitatively detect the expressions of GPC3 and Notch1 in 30 HCC tissue specimens.
  
  
  RESULTS
  In the 30 HCC specimens, GPC3 expression decreased significantly as the grade of tumor differentiation increased (P<0.05 or P<0.01), while Notch1 expression presented with a reverse pattern of changes (P<0.05 or P<0.01). An obvious negative correlation was found between the expressions of GPC3 and Notch1 in HCC tissues (rp=-0.607, P=0.000; r=-0.692, P=0.000).
  
  
  CONCLUSIONS
  The expressions of GPC3 and Notch1 show a negative correlation in HCC, suggesting a possible mechanism for mutual regulation between them to contribute to the tumorigenesis and progression of HCC.
authors: Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. fhxzsm@163.com
authors: Fanli
authors: F
authors: Peng
authors: Ziqing
authors: Z
authors: Wu
authors: Xuenong
authors: X
authors: Li
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D053673:Glypicans / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051881:Receptor, Notch1 / Q000378:metabolism*
chemical_list: C105937:GPC3 protein, human; D053673:Glypicans; C497761:NOTCH1 protein, human; D051881:Receptor, Notch1