title: Effects of phospholipid hepatoprotectors on apoptosis during experimental liver pathology induced by isoniazid and paracetamol.
abstract: Phospholipid hepatoprotectors essentiale, eplir, and their combinations with succinic acid decreased the relative content of apoptotic lymphocytes and granulocytes in the blood, content of TNF-α, total and indirect bilirubin, and activities of transaminases and alkaline phosphatase and increase the content of IL-10 in rats with experimental intoxication induced by isoniazid and paracetamol. A combination of eplir and succinic acid was most effective in preventing the development of leukocyte apoptosis.
authors: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Russia. udutv@mail.ru
authors: V V
authors: VV
authors: Udut
authors: A I
authors: AI
authors: Vengerovsky
authors: A M
authors: AM
authors: Dygai
mesh_terms: D000082:Acetaminophen / Q000633:toxicity; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001663:Bilirubin / Q000097:blood; D002338:Carotenoids / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D004338:Drug Combinations; D006098:Granulocytes / Q000187:drug effects* / Q000378:metabolism; D016753:Interleukin-10 / Q000097:blood; D007538:Isoniazid / Q000633:toxicity; D008111:Liver Function Tests; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010743:Phospholipids / Q000494:pharmacology*; D051381:Rats; D019802:Succinic Acid / Q000494:pharmacology*; D000637:Transaminases / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D004338:Drug Combinations; D010713:Phosphatidylcholines; D010743:Phospholipids; D014409:Tumor Necrosis Factor-alpha; C064845:eplir; C011246:essential 303 forte; D016753:Interleukin-10; D002338:Carotenoids; D000082:Acetaminophen; D019802:Succinic Acid; D000637:Transaminases; D000469:Alkaline Phosphatase; D001663:Bilirubin; D007538:Isoniazid