title: Enantioselective synthesis of (thiolan-2-yl)diphenylmethanol and its application in asymmetric, catalytic sulfur ylide-mediated epoxidation.
abstract: This work describes an expeditious and efficient preparation of enantiopure (thiolan-2-yl)diphenylmethanol (2) featuring a double nucleophilic substitution and Shi epoxidation as key steps. One of the applications of its benzyl ether derivative to asymmetric sulfur ylide-mediated epoxidation with up to 92% ee (14 examples) was also demonstrated herein.
authors: Department of Chemistry, National Central University, Taoyuan, Taiwan 32001.
authors: Hsin-Yi
authors: HY
authors: Wu
authors: Chih-Wei
authors: CW
authors: Chang
authors: Rong-Jie
authors: RJ
authors: Chein
mesh_terms: D001592:Benzyl Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: C585107:(thiolan-2-yl)diphenylmethanol; D001592:Benzyl Alcohols; D004852:Epoxy Compounds; D013438:Sulfhydryl Compounds