title: iFUSE: integrated fusion gene explorer.
abstract: We present iFUSE (integrated fusion gene explorer), an online visualization tool that provides a fast and informative view of structural variation data and prioritizes those breaks likely representing fusion genes. This application uses calculated break points to determine fusion genes based on the latest annotation for genomic sequence information, and where relevant the structural variation (SV) events are annotated with predicted RNA and protein sequences. iFUSE takes as input a Complete Genomics (CG) junction file, a FusionMap fusion detection report file or a file already analysed and annotated by the iFUSE application on a previous occasion.
  
  
  RESULTS
  We demonstrate the use of iFUSE with case studies from tumour-normal SV detection derived from Complete Genomics whole-genome sequencing results.
  
  
  BACKGROUND
  iFUSE is available as a web service at http://ifuse.erasmusmc.nl.
authors: Department of Urology, Erasmus MC, 3015 GE Rotterdam, The Netherlands. s.hiltemann@erasmusmc.nl
authors: Saskia
authors: S
authors: Hiltemann
authors: Elizabeth A
authors: EA
authors: McClellan
authors: Jos
authors: J
authors: van Nijnatten
authors: Sebastiaan
authors: S
authors: Horsman
authors: Ivo
authors: I
authors: Palli
authors: Ines
authors: I
authors: Teles Alves
authors: Thomas
authors: T
authors: Hartjes
authors: Jan
authors: J
authors: Trapman
authors: Peter
authors: P
authors: van der Spek
authors: Guido
authors: G
authors: Jenster
authors: Andrew
authors: A
authors: Stubbs
mesh_terms: D050939:Gene Fusion; D052138:Genes, Neoplasm; D056914:Genomic Structural Variation; D023281:Genomics / Q000379:methods; D006801:Humans; D012984:Software