title: Laparoscopic versus open surgery for colon cancer: a meta-analysis of 5-year follow-up outcomes.
abstract: BACKGROUND
  Colon cancer is one of the most common malignant tumors of digestive tract with a rather high incidence rate. Currently, surgery is the only radical therapy for colon cancer, while Laparoscopic colectomy (LAC) has become another focus since studies reported LAC could improve the short-time outcomes and quick recovery of patients compared with open colectomy (OC). However, it's still unclear whether LAC can better improve patients' long-time survival than OC.
  
  
  OBJECTIVE
  We aimed to perform a meta-analysis to answer whether the 5-year recurrence and survival rate after LAC are comparable to those reported after OC in patient with colon cancer.
  
  
  METHODS
  We searched Cochrane Library, PubMed, Embase, CBM, VIP, and CNKI for relevant studies. The time searched was from the establishment time of the databases to September 15, 2011. At the same time, we searched Google, Medical Martix and Baidu for more studies as well as a hand-search. We limited the language to English and Chinese. Two reviewers independently screened articles to identify randomized controlled trials (RCTs) according to the inclusion and exclusion criteria and assessed the methodological quality of included trials, and then extracted data. Meta-analysis was performed using RevMan5.0.
  
  
  RESULTS
  Five RCTs involving 2695 patients reported long-term outcomes based on 5-year data and were included in the analysis. No significant differences between LAC and OC were found in the overall mortality (RR = 0.94; 95% CI (0.82, 1.09); P = 0.23, I(2) = 21%), total recurrence rate (RR = 0.94; 95% CI (0.81, 1.10); P = 0.24, I(2) = 27%), 5-year tumor free survival rate (RR = 1.00, 95% CI (0.94, 1.06); P = 0.96, I(2) = 0%). and overall 5-year survival (RR = 1.02; 95% CI (0.97, 1.07); P = 0.55, I(2) = 0%).
  
  
  CONCLUSIONS
  This meta-analysis suggests that LAC was as effective and safe as OC for colon cancer.
authors: Department of Emergency Surgery, Gansu Provincial Hospital, Lanzhou 730000, China.
authors: Baoshan
authors: B
authors: Di
authors: Yan
authors: Y
authors: Li
authors: Kongping
authors: K
authors: Wei
authors: Xiaojuan
authors: X
authors: Xiao
authors: Jie
authors: J
authors: Shi
authors: Yan
authors: Y
authors: Zhang
authors: Xiaoqin
authors: X
authors: Yang
authors: Peng
authors: P
authors: Gao
authors: Ke
authors: K
authors: Zhang
authors: Yuan
authors: Y
authors: Yuan
authors: Dongzhi
authors: D
authors: Zhang
authors: Xiaodong
authors: X
authors: Wei
authors: Shaoguang
authors: S
authors: Liu
authors: Jianping
authors: J
authors: Wang
authors: Xuebing
authors: X
authors: Wang
authors: Yingmei
authors: Y
authors: Zhang
authors: Hui
authors: H
authors: Cai
mesh_terms: D006801:Humans; D003082:Colectomy; D003110:Colonic Neoplasms / Q000601:surgery; D010535:Laparoscopy; D011379:Prognosis; D013997:Time Factors
keywords: Colon cancer; Laparoscopic surgery; Meta-analysis; Open surgery