title: Innate receptors for adaptive immunity.
abstract: Pattern recognition receptors (PRRs) are commonly known as sensor proteins crucial for the early detection of microbial or host-derived stress signals by innate immune cells. Interestingly, some PRRs are also expressed and functional in cells of the adaptive immune system. These receptors provide lymphocytes with innate sensing abilities; for example, B cells express Toll-like receptors, which are important for the humoral response. Strikingly, certain other NOD-like receptors are not only highly expressed in adaptive immune cells, but also exert functions related specifically to adaptive immune system pathways, such as regulating antigen presentation. In this review, we will focus particularly on the current understanding of PRR functions intrinsic to B and T lymphocytes; a developing aspect of PRR biology.
authors: Centre International de Recherche en Infectiologie (CIRI), INSERM U1111 - CNRS UMR5308, Université de Lyon 1, ENS de Lyon, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07, France.
authors: Marie-Cécile
authors: MC
authors: Michallet
authors: Giorgia
authors: G
authors: Rota
authors: Kendle
authors: K
authors: Maslowski
authors: Greta
authors: G
authors: Guarda
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D051192:Receptors, Pattern Recognition / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D051192:Receptors, Pattern Recognition