title: Simulation of intra-aneurysmal blood flow by different numerical methods.
abstract: The occlusional performance of sole endoluminal stenting of intracranial aneurysms is controversially discussed in the literature. Simulation of blood flow has been studied to shed light on possible causal attributions. The outcome, however, largely depends on the numerical method and various free parameters. The present study is therefore conducted to find ways to define parameters and efficiently explore the huge parameter space with finite element methods (FEMs) and lattice Boltzmann methods (LBMs). The goal is to identify both the impact of different parameters on the results of computational fluid dynamics (CFD) and their advantages and disadvantages. CFD is applied to assess flow and aneurysmal vorticity in 2D and 3D models. To assess and compare initial simulation results, simplified 2D and 3D models based on key features of real geometries and medical expert knowledge were used. A result obtained from this analysis indicates that a combined use of the different numerical methods, LBM for fast exploration and FEM for a more in-depth look, may result in a better understanding of blood flow and may also lead to more accurate information about factors that influence conditions for stenting of intracranial aneurysms.
authors: Department of Computer Science VII, Dortmund University of Technology, Dortmund, Germany. frank.weichert@tu-dortmund.de
authors: Frank
authors: F
authors: Weichert
authors: Lars
authors: L
authors: Walczak
authors: Denis
authors: D
authors: Fisseler
authors: Tobias
authors: T
authors: Opfermann
authors: Mudassar
authors: M
authors: Razzaq
authors: Raphael
authors: R
authors: Münster
authors: Stefan
authors: S
authors: Turek
authors: Iris
authors: I
authors: Grunwald
authors: Christian
authors: C
authors: Roth
authors: Christian
authors: C
authors: Veith
authors: Mathias
authors: M
authors: Wagner
mesh_terms: D002560:Cerebrovascular Circulation; D019295:Computational Biology; D020342:Finite Element Analysis; D006801:Humans; D057446:Hydrodynamics; D021621:Imaging, Three-Dimensional; D002532:Intracranial Aneurysm / Q000503:physiopathology* / Q000628:therapy; D008955:Models, Cardiovascular; D012039:Regional Blood Flow; D015607:Stents
references: J Neurosurg. 2006 Feb;104(2):195-200
references: 16509492
references: Eur J Radiol. 2012 Jun;81(6):1276-81
references: 21435809
references: Ann Biomed Eng. 2008 May;36(5):726-41
references: 18264766
references: Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1993 Mar;47(3):1815-1819
references: 9960203
references: Neurosurgery. 2011 Aug;69(2):349-56
references: 21415785
references: J Korean Neurosurg Soc. 2009 Feb;45(2):85-9
references: 19274117
references: J Biomech Eng. 2004 Feb;126(1):36-43
references: 15171127
references: Neurol Med Chir (Tokyo). 2010;50(9):777-87
references: 20885112
references: J Neurosurg. 2006 Feb;104(2):188-94
references: 16509491
references: J Neuroradiol. 2008 May;35(2):99-103
references: 18242707
references: AJNR Am J Neuroradiol. 2011 Feb;32(2):264-70
references: 21051508
references: Lancet. 2002 Oct 26;360(9342):1267-74
references: 12414200
references: Neuroradiology. 2011 Jul;53(7):501-8
references: 20838782
references: J Biomech Eng. 1997 May;119(2):206-12
references: 9168397
references: Math Biosci Eng. 2011 Apr;8(2):409-23
references: 21631137
references: Ann Biomed Eng. 2002 Jun;30(6):768-77
references: 12220077
references: Neurosurgery. 2008 Apr;62(4):767-73; discussion 773-5
references: 18496182