title: Fluid intake, genetic variants of UDP-glucuronosyltransferases, and bladder cancer risk.
abstract: BACKGROUND
  Results of studies of fluid consumption and its association with bladder cancer have been inconsistent. Few studies have considered modification effects from genetic variants that may interact with the type of consumed fluids. UDP-glucuronosyltransferases (UGTs), which are membrane-bound conjugating enzymes, catalyse the transformation of hydrophobic substrates to more water-soluble glucuronides to facilitate renal or biliary excretion. Whether genetic variants in UGTs could modulate the association between fluid intake and bladder cancer has not been studied.
  
  
  METHODS
  We conducted a case-control study with 1007 patients with histopathologically confirmed bladder cancer and 1299 healthy matched controls. Fluid intake and epidemiologic data were collected via in-person interview. Multivariate unconditional logistic regression was used to estimate odds ratios (ORs) and the 95% confidence intervals (95% CI).
  
  
  RESULTS
  After adjustment for potential confounders, high quantity of total fluid intake (> or =2789 vs. <1696 ml per day) conferred a 41% increased risk of bladder cancer (OR=1.41; 95% CI=1.10-1.81). Specific fluids such as regular soft drinks and decaffeinated coffee were also associated with increased risks, whereas tea, wine, and liquor were associated with decreased risks. Among 83 single-nucleotide polymorphisms in the UGT gene family, 18 were significantly associated with bladder cancer risk. The most significant one was rs7571337, with the variant genotype conferring a 29% reduction in risk (OR=0.71; 95% CI=0.56-0.90).
  
  
  CONCLUSIONS
  Total and specific fluid intakes are associated with bladder cancer risk in the study population and that genetic variants of UGT genes could modulate the effects. These results facilitate identification of high-risk individuals and have important implications in bladder cancer prevention.
authors: Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Boulevard, Houston, Texas 77030, USA.
authors: J
authors: J
authors: Wang
authors: X
authors: X
authors: Wu
authors: A
authors: A
authors: Kamat
authors: H
authors: H
authors: Barton Grossman
authors: C P
authors: CP
authors: Dinney
authors: J
authors: J
authors: Lin
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000201:enzymology / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D016022:Case-Control Studies; D004326:Drinking; D005260:Female; D020022:Genetic Predisposition to Disease; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013781:Texas / Q000453:epidemiology; D001749:Urinary Bladder Neoplasms / Q000201:enzymology / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics
chemical_list: D014453:Glucuronosyltransferase
references: Cancer Causes Control. 2009 Feb;20(1):121-7
references: 18798002
references: Pharmacogenetics. 2003 Aug;13(8):517-23
references: 12893990
references: Mol Nutr Food Res. 2008 Apr;52(4):408-18
references: 18381677
references: Cancer Sci. 2009 Feb;100(2):294-91
references: 19068095
references: Nutr Cancer. 1997;29(2):163-8
references: 9427981
references: Eur J Cancer Prev. 2009 Feb;18(1):62-8
references: 19077567
references: J Natl Cancer Inst. 1987 Dec;79(6):1269-79
references: 3480378
references: Epidemiology. 2004 May;15(3):357-67
references: 15097021
references: CA Cancer J Clin. 2011 Jul-Aug;61(4):212-36
references: 21685461
references: Altern Ther Health Med. 2007 Mar-Apr;13(2):S108-11
references: 17405687
references: Oncol Rep. 2005 Feb;13(2):185-91
references: 15643497
references: Int J Cancer. 2007 Aug 15;121(4):839-45
references: 17440923
references: BJU Int. 2008 Nov;102(9 Pt B):1207-15
references: 19035883
references: Scand J Urol Nephrol Suppl. 2008 Sep;(218):37-44
references: 18815915
references: Nat Genet. 2010 Nov;42(11):978-84
references: 20972438
references: Int Rev Cytol. 2007;260:35-112
references: 17482904
references: Int J Cancer. 2001 Jan 1;91(1):141-3
references: 11149414
references: Int J Cancer. 2001 Sep;93(6):880-7
references: 11519052
references: J Biochem. 2010 Mar;147(3):353-60
references: 19880377
references: Environ Health Perspect. 2007 Nov;115(11):1569-72
references: 18007986
references: Nat Clin Pract Urol. 2006 Jun;3(6):327-40
references: 16763645
references: Int J Cancer. 2011 Jun 1;128(11):2695-708
references: 20715171
references: Nutr Cancer. 1987;9(4):199-217
references: 3299283
references: Cancer Epidemiol Biomarkers Prev. 2010 Feb;19(2):447-55
references: 20142243
references: Cancer Lett. 2009 May 18;277(2):121-5
references: 18834663
references: Curr Drug Metab. 2000 Sep;1(2):143-61
references: 11465080
references: Pharmacogenomics J. 2003;3(3):136-58
references: 12815363
references: Crit Rev Food Sci Nutr. 2006;46(2):101-23
references: 16507475
references: Int J Cancer. 2008 Oct 1;123(7):1649-56
references: 18623082
references: Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):77-83
references: 15979674
references: J Clin Oncol. 2007 Nov 1;25(31):4974-81
references: 17971596
references: Am J Epidemiol. 1986 Oct;124(4):578-89
references: 3752052
references: Arch Environ Health. 1993 May-Jun;48(3):191-8
references: 8333791
references: Toxicol Sci. 2005 May;85(1):502-6
references: 15615884
references: Nat Rev Cancer. 2009 Jun;9(6):429-39
references: 19472429
references: Cancer Prev Res (Phila). 2010 Apr;3(4):505-17
references: 20354165
references: Am J Epidemiol. 2010 Mar 15;171(6):701-8
references: 20160170
references: Eur J Clin Nutr. 2003 Dec;57 Suppl 2:S59-68
references: 14681715
references: J Am Diet Assoc. 1992 Jun;92(6):686-93
references: 1607564
references: Nutr Cancer. 1998;31(3):151-9
references: 9795966
references: Cochrane Database Syst Rev. 2009 Jul 08;(3):CD005004
references: 19588362
references: Cancer Causes Control. 2001 Apr;12(3):231-8
references: 11405328
references: Int J Cancer. 2006 Apr 15;118(8):2040-7
references: 16284957
references: Scand J Urol Nephrol Suppl. 2008 Sep;(218):25-36
references: 18815914
references: N Engl J Med. 1999 May 6;340(18):1390-7
references: 10228189