title: Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment.
abstract: Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3). Our results showed the following associations: IFNG +874 T allele and IFNG +2109 A allele with higher IFN- γ levels; IL12B +1188 C allele with higher IL-12 levels; TNF -308 A allele with higher TNF- α plasma levels in controls and mRNA levels in PTB patients at T1; IL17A A allele at rs7747909 with higher IL-17 levels; IL10 -819 T allele with higher IL-10 levels; and TGFB1 +29 CC genotype higher TGF- β plasma levels in PTB patients at T2. The present study suggests that IFNG +874T/A, IFNG +2109A/G, IL12B +1188A/C, IL10 -819C/T, and TGFB1 +21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment.
authors: Tropical Disease Department, Botucatu School of Medicine, UNESP, São Paulo State University, Botucatu, SP, Brazil ; Departamento de Doenças Tropicais e Diagnóstico por Imagem, Faculdade de Medicina de Botucatu, UNESP, Rubião Júnior S/N, Botucatu 18618-970, SP, Brazil.
authors: Eliana
authors: E
authors: Peresi
authors: Larissa Ragozo Cardoso
authors: LR
authors: Oliveira
authors: Weber Laurentino
authors: WL
authors: da Silva
authors: Erika Alessandra Pellison Nunes
authors: EA
authors: da Costa
authors: João Pessoa
authors: JP
authors: Araujo
authors: Jairo Aparecido
authors: JA
authors: Ayres
authors: Maria Rita Parise
authors: MR
authors: Fortes
authors: Edward A
authors: EA
authors: Graviss
authors: Ana Carla
authors: AC
authors: Pereira
authors: Sueli Aparecida
authors: SA
authors: Calvi
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