title: [Effect of antihypoxant infusion on microbial endotoxin circulation in obstructive jaundice patients].
abstract: The dynamics of microbial endotoxemia in group of 149 patients with cholelithiasis complicated by obstructive jaundice has been studied as dependent on the perioperative tactics of infusion therapy. The perioperative period in obstructive jaundice patients is complicated by a significant increase in lipopolysaccharidemia caused by translocation mechanisms and disorders of the liver detoxification function. In Group 1, 47 patients received infusion therapy including Ringer's solution and 10% glucose solution at a 1:1 ratio. In group 2, 55 patients received infusion therapy with only Sterofundin G-5 solution. In Group 3, 47 patients received the infusion therapy with remaxol in a dose of 800 ml/day. It is established that the infusion of Sterofundin G-5, and to a greater extent the infusion of remaxol, reduces the early postoperative degree of decompensation and accelerates recovery of the detoxifying function of Kupffer cells with respect to microbial endotoxin.
authors: A Ia
authors: AIa
authors: Iakovlev
authors: A A
authors: AA
authors: Niazmatov
authors: N V
authors: NV
authors: Zarechnova
authors: R R
authors: RR
authors: Zaĭtsev
authors: N V
authors: NV
authors: Emel'ianov
authors: K V
authors: KV
authors: Mokrov
authors: A S
authors: AS
authors: Chichkanova
mesh_terms: D002769:Cholelithiasis / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D019446:Endotoxemia / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D005440:Fluid Therapy; D005947:Glucose / Q000494:pharmacology / Q000627:therapeutic use; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007263:Infusions, Parenteral; D007552:Isotonic Solutions / Q000494:pharmacology / Q000627:therapeutic use; D041781:Jaundice, Obstructive / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D007728:Kupffer Cells / Q000187:drug effects / Q000378:metabolism; D008070:Lipopolysaccharides / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009930:Organic Chemicals / Q000494:pharmacology / Q000627:therapeutic use; D000077331:Ringer's Solution; D013386:Succinates / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D007552:Isotonic Solutions; D008070:Lipopolysaccharides; D009930:Organic Chemicals; C555877:Remaxol; D013386:Succinates; C052337:sterofundin; D000077331:Ringer's Solution; D005947:Glucose