title: Models for estimating the biological age of five organs using clinical biomarkers that are commonly measured in clinical practice settings.
abstract: OBJECTIVE
  To date, no worldwide studies have been conducted to estimate the biological age of five organs using clinical biomarkers that are associated with the aging status. Therefore, we conducted this study to develop the models for estimating the biological age of five organs (heart, lung, liver, pancreas, and kidney) using clinical biomarkers which are commonly measured in clinical practice.
  
  
  METHODS
  A cross sectional study.
  
  
  METHODS
  Subjects were recruited from the routine health check-up centers in Korea from 2004 through 2010. Data obtained from 121,189 subjects (66,168 men and 55,021 women) were used for clinical evaluation and statistical analysis. We examined the relations between clinical biomarkers associated with five organs and the chronological age and proposed a model for estimating the biological age of five organs.
  
  
  RESULTS
  In the models for predicting the biological ages of the heart, lung, liver, pancreas and kidney in men, 12, 2, 8, 3, and 5 parameters were respectively included (R(2)=0.652, 0.427, 0.107, 0.245, and 0.651). In contrast to men, 10, 2, 8, 3, and 5 parameters in women were respectively included (R(2)=0.780, 0.435, 0.140, 0.384, and 0.501).
  
  
  CONCLUSIONS
  We first proposed the models for predicting the biological age of five organs in the current study. We developed those using clinical parameters that can be easily obtained in clinical practice settings. Our biological age prediction models may be used as supplementary tools to assess the aging status of five organs in clinical practice settings.
authors: MediAge Research Center, 705-9 Yeoksam-Dong, Gangnam-Gu, Seoul, South Korea. baecy@naver.com
authors: Chul-Young
authors: CY
authors: Bae
authors: Young Gon
authors: YG
authors: Kang
authors: Mei-Hua
authors: MH
authors: Piao
authors: Belong
authors: B
authors: Cho
authors: Kyung Hee
authors: KH
authors: Cho
authors: Yong Kyu
authors: YK
authors: Park
authors: Byung Yeon
authors: BY
authors: Yu
authors: Sang-Wha
authors: SW
authors: Lee
authors: Moon Jong
authors: MJ
authors: Kim
authors: Sang Hyun
authors: SH
authors: Lee
authors: Yun-Jin
authors: YJ
authors: Kim
authors: Dae-Hyun
authors: DH
authors: Kim
authors: Jong Sung
authors: JS
authors: Kim
authors: Jeong Eun
authors: JE
authors: Oh
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D003430:Cross-Sectional Studies; D005260:Female; D006321:Heart; D006801:Humans; D007668:Kidney; D007723:Korea; D008099:Liver; D008168:Lung; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010179:Pancreas; D055815:Young Adult