title: Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans.
abstract: Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.
authors: Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 - CNRS - University Montpellier I and II - ENSCM, Faculty of Pharmacy, Montpellier, France.
authors: Jean-Marie
authors: JM
authors: Galano
authors: Emilie
authors: E
authors: Mas
authors: Anne
authors: A
authors: Barden
authors: Trevor A
authors: TA
authors: Mori
authors: Cinzia
authors: C
authors: Signorini
authors: Claudio
authors: C
authors: De Felice
authors: Aaron
authors: A
authors: Barrett
authors: Catherine
authors: C
authors: Opere
authors: Edith
authors: E
authors: Pinot
authors: Edzard
authors: E
authors: Schwedhelm
authors: Ralf
authors: R
authors: Benndorf
authors: Jérôme
authors: J
authors: Roy
authors: Jean-Yves
authors: JY
authors: Le Guennec
authors: Camille
authors: C
authors: Oger
authors: Thierry
authors: T
authors: Durand
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000378:metabolism; D006439:Hemodynamics; D006801:Humans; D028421:Isoprostanes / Q000096:biosynthesis*; D015227:Lipid Peroxidation; D058632:Neuroprostanes / Q000096:biosynthesis*; D018384:Oxidative Stress; D015427:Reperfusion Injury / Q000378:metabolism
chemical_list: D015415:Biomarkers; D015525:Fatty Acids, Omega-3; D028421:Isoprostanes; D058632:Neuroprostanes
keywords: Bioactive lipids; Biomarkers; Isoprostanes; Metabolites; Neuroprostanes; PUFAs