title: Free radical oxidation in rats in the delayed period after combined exposure to dust and radiation.
abstract: We studied the intensity of free radical processes in organs (liver, spleen, thymus, lymph nodes of the small intestine, and adrenal glands) and cells (lymphocytes) in the delayed period after combined exposure to a sublethal dose of γ-radiation (6 Gy) and asbestos dust particles. Combined exposure was followed by accumulation of LPO metabolites (diene conjugates and malonic dialdehyde) in homogenates of the studied organs and resulted in antioxidant defense failure in experimental animals. Ionizing radiation have a pivotal role in these processes.
authors: Department of Biochemistry, Central Research Laboratory, State Medical University, Semey, Kazakhstan.
authors: S O
authors: SO
authors: Tapbergenov
authors: B A
authors: BA
authors: Zhetpisbaev
authors: O Z
authors: OZ
authors: Ilderbayev
authors: H S
authors: HS
authors: Zhetpisbaeva
authors: R R
authors: RR
authors: Olzhayeva
authors: I I
authors: II
authors: Prozor
authors: O A
authors: OA
authors: Usenova
authors: G O
authors: GO
authors: Ilderbayeva
mesh_terms: D000222:Adaptation, Physiological; D000311:Adrenal Glands / Q000378:metabolism / Q000528:radiation effects; D000818:Animals; D021461:Animals, Outbred Strains; D001194:Asbestos / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D004195:Disease Models, Animal; D004391:Dust; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism / Q000528:radiation effects; D008198:Lymph Nodes / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D016273:Occupational Exposure; D009928:Organ Specificity; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011848:Radioactive Pollutants / Q000633:toxicity*; D051381:Rats; D013154:Spleen / Q000378:metabolism / Q000528:radiation effects; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects
chemical_list: D002273:Carcinogens; D004391:Dust; D005609:Free Radicals; D011848:Radioactive Pollutants; D001194:Asbestos; D008315:Malondialdehyde