title: The presence of old pulmonary tuberculosis is an independent prognostic factor for squamous cell lung cancer survival.
abstract: BACKGROUND
  Pulmonary tuberculosis (TB) is associated with an increased risk of lung cancer. Our study investigated whether the coexistence of an old pulmonary TB lesion is an independent prognostic factor for lung cancer survival in Chinese non-small cell lung cancer patients.
  
  
  METHODS
  We performed a retrospective review of 782 non-small cell lung cancer patients who underwent surgical resection as their primary treatment in 2006 and were followed for 5 years. The associations between lung cancer survival and the presence of old pulmonary TB lesions were assessed using Cox's proportional hazard regression analysis adjusted for WHO performance status (PS), age, sex, smoking-status, tumor stage, and surgical approach.
  
  
  RESULTS
  Sixty-four of the patients had old pulmonary TB lesions. The median survival of squamous cell carcinoma patients with TB was significantly shorter than that of patients without TB (1.7 vs. 3.4 years, p < 0.01). The presence of an old pulmonary TB lesion is an independent predictor of poor survival with a hazard ratio (HR) of 1.72 (95% CI, 1.12-2.64) in the subgroup of squamous cell carcinoma patients studied.
  
  
  CONCLUSIONS
  The presence of an old pulmonary TB lesion may be an important prognostic factor for predicting the survival of squamous cell carcinoma patients.
authors: Department of Thoracic Surgery, Tongji University School of Medicine, Shanghai, China.
authors: Yiming
authors: Y
authors: Zhou
authors: Zhenling
authors: Z
authors: Cui
authors: Xiao
authors: X
authors: Zhou
authors: Chang
authors: C
authors: Chen
authors: Sen
authors: S
authors: Jiang
authors: Zhongyi
authors: Z
authors: Hu
authors: Gening
authors: G
authors: Jiang
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D016009:Chi-Square Distribution; D002681:China; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000150:complications*
references: PLoS One. 2012;7(3):e33226
references: 22438899
references: World J Surg Oncol. 2007 Feb 19;5:22
references: 17309797
references: Jpn J Clin Oncol. 1996 Oct;26(5):322-7
references: 8895672
references: J Thorac Oncol. 2011 Jan;6(1):32-7
references: 21150470
references: CA Cancer J Clin. 2012 Jan-Feb;62(1):10-29
references: 22237781
references: AJR Am J Roentgenol. 1995 Jun;164(6):1361-7
references: 7754873
references: Int J Cancer. 2009 Dec 15;125(12):2936-44
references: 19521963
references: Lung Cancer. 2012 Jun;76(3):452-6
references: 22226628
references: Int J Cancer. 2009 Mar 1;124(5):1183-7
references: 19058197
references: Cancer Epidemiol Biomarkers Prev. 2011 Apr;20(4):672-8
references: 21335509
references: J Thorac Oncol. 2012 Feb;7(2):299-305
references: 22173705
references: Oncogene. 2009 Apr 30;28(17):1928-38
references: 19330024
references: Lung Cancer. 2010 Apr;68(1):20-6
references: 19545930