title: Honokiol analogs: a novel class of anticancer agents targeting cell signaling pathways and other bioactivities.
abstract: Honokiol (3,5-di-(2-propenyl)-1,1-biphenyl-2,2-diol) is a natural bioactive neolignan isolated from the genus Magnolia. In recent studies, honokiol has been observed to have anti-angiogenic, anticancer, anti-inflammatory, neuroprotective and GABA-modulating properties in vitro and in preclinical models. Honokiol and its analogs target multiple signaling pathways including NF-κB, STAT3, EGFR, mTOR and caspase-mediated common pathway, which regulate cancer initiation and progression. Honokiol and its targets of action may be helpful in the development of effective analogs and targeted cancer therapy. In this review, recent data describing the molecular targets of honokiol and its analogs with anticancer and some other bioactivities are discussed.
authors: Kharvel Subharti College of Pharmacy, Swami Vivekanand Subharti University, NH-58, Meerut Bypass Road, Meerut-250005, India. ankit_manipal07@yahoo.co.in
authors: Ankit
authors: A
authors: Kumar
authors: Umesh
authors: U
authors: Kumar Singh
authors: Anurag
authors: A
authors: Chaudhary
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D001713:Biphenyl Compounds / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D020169:Caspases / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D031566:Magnolia / Q000737:chemistry; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010739:Phospholipase D / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D020169:Caspases; D017705:Lignans; D016328:NF-kappa B; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010739:Phospholipase D; D058570:TOR Serine-Threonine Kinases; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols