title: [Compounds in tobacco smoke and pathogenesis of the diseases].
abstract: Tobacco smoke is a complex mixture of more than 5,000 compounds including about 200 hazardous chemicals. These chemicals are distributed between the particulate and vapor phases of the smoke, and initiate and progress various human diseases. Polycyclic aromatic hydrocarbons existing in tar can induce DNA damage by direct addiction and cause cancers in respiratory tract. Carbon monoxide must jam normal oxygen transport to tissue and enhance the severity of cardiovascular disease. Oxidative stress induced by hazardous compounds in smoke results in pulmonary disease. Nicotine promotes physical addiction to tobacco as well as causes pulmonary diseases, cardiovascular diseases or cancers to smokers. We should investigate compounds in smoke from new type of cigarette and must educate citizens to avoid risky compounds to our health.
authors: Department of Respiratory Medicine, Kitasato University School of Medicine.
authors: Jiichiro
authors: J
authors: Sasaki
mesh_terms: D002248:Carbon Monoxide / Q000009:adverse effects; D004249:DNA Damage / Q000187:drug effects; D006331:Heart Diseases / Q000139:chemically induced*; D006801:Humans; D007564:Japan; D009538:Nicotine / Q000009:adverse effects*; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology*; D012907:Smoking / Q000009:adverse effects*
chemical_list: D009538:Nicotine; D002248:Carbon Monoxide