title: Orbital invasion by ACTH-secreting pituitary adenomas.
abstract: Orbital invasion by pituitary tumors is rare. To the best of the authors' knowledge, adrenocorticotrophin (ACTH)-secreting pituitary tumors with orbital invasion have not been described in MEDLINE indexed literature. The authors report 2 cases of ACTH-secreting tumors with orbital invasion. One patient had a history of endoscopic transsphenoidal subtotal resection of an ACTH-secreting tumor and presented with recurrence in the orbit. The second patient had a long history of visual loss considered to be secondary to glaucoma. Neuroimaging revealed a destructive mass involving the sella turcica with extension in the right orbit. Debulking of the mass was performed via a transsphenoidal approach, and histopathology revealed an ACTH-secreting adenoma. ACTH-secreting adenoma should be considered in the differential of tumors involving the sella turcica with orbital invasion.
authors: *University of Colorado School of Medicine, Aurora, Colorado, U.S.A.; †Department of Ophthalmology, University of Colorado Eye Center, Aurora, Colorado, U.S.A.; ‡Department of Neurosurgery, School of Medicine, University of Colorado Denver, Aurora, Colorado, U.S.A; and §South Denver Neurosurgery, Denver, Colorado, U.S.A.
authors: Jasmeet S
authors: JS
authors: Dhaliwal
authors: Leonard K
authors: LK
authors: Seibold
authors: B K
authors: BK
authors: Kleinschmidt-Demasters
authors: Kevin O
authors: KO
authors: Lillehei
authors: Eric M
authors: EM
authors: Hink
authors: J Adair
authors: JA
authors: Prall
authors: Vikram D
authors: VD
authors: Durairaj
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma / Q000473:pathology* / Q000601:surgery; D000236:Adenoma / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009361:Neoplasm Invasiveness; D009918:Orbital Neoplasms / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies