title: Computational fluid dynamics study of the optimal design and operating conditions of the segmentation ring used in parallel segmented flow columns.
abstract: We report on a numerical study wherein we modeled the influence of the segmentation ring used in the recently introduced parallel segmented flow concept. The study reconfirms that the parallel segmented flow concept can indeed improve separation performance of radially heterogeneous beds. It was however also found that the segmentation ring in itself introduces significant flow disturbances. Depending on its thickness and the fraction of the total flow rate going through the central opening, the ring itself can constitute a loss in volumetric variance (σv(2)) in the order of a few up to a few tens of μl(2). Although the ideal flow-split ring would be infinitely thin, it was found that halving the current 0.62mm ring thickness used in literature to 0.31mm would already eliminate most of its negative effect. At the inlet, the optimal central flow rate fraction for a 0.62mm as well as a 0.31mm wide ring in a 4.6mm I.D. column lies in the range of 0.25-0.4. At the outlet, the optimal range is 0.15-0.4.
authors: Vrije Universiteit Brussel, Department of Chemical Engineering, Pleinlaan 2, 1050 Brussels, Belgium.
authors: Wim
authors: W
authors: Smits
authors: Gert
authors: G
authors: Desmet
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D057446:Hydrodynamics; D008962:Models, Theoretical