title: Patient-reported genitourinary toxicity for long-term prostate cancer survivors treated with radiation therapy.
abstract: BACKGROUND
  The objective of this study is to provide comprehensive overviews of patient-reported urinary symptoms for long-term prostate cancer survivors treated with radiation therapy and for untreated, healthy men.
  
  
  METHODS
  We performed a population-based cross-sectional study using a study-specific postal questionnaire assessing symptoms among 1007 men consecutively treated at the Sahlgrenska University Hospital, Göteborg, Sweden from 1993-2006 (primary or salvage external beam radiation therapy (EBRT) or EBRT and high-dose rate brachytherapy). We also randomly recruited 350 non-pelvic-irradiated matched control men from the Swedish Total Population Register. Symptom prevalence and prevalence ratios were computed.
  
  
  RESULTS
  Survey participation rate was 89% (874/985) for eligible survivors and 73% (243/332) for eligible controls. Median time from treatment to follow-up was 5 years (range, 1-14 years). Among the 21 investigated symptoms reflecting obstruction, frequency, urgency, pain and incontinence, we found significantly higher prevalence compared with controls for 9 symptoms in the EBRT group, 10 in the EBRT+brachytherapy group and 5 in the salvage EBRT group. The prevalence for a majority of the symptoms was stable over time.
  
  
  CONCLUSIONS
  The presented toxicity profiles provide a thorough understanding of patient-reported urinary symptoms that can assist in developing personalised therapy for prostate cancer.
authors: Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden. caroline.olsson@oc.gu.se
authors: C E
authors: CE
authors: Olsson
authors: N
authors: N
authors: Pettersson
authors: D
authors: D
authors: Alsadius
authors: U
authors: U
authors: Wilderäng
authors: S L
authors: SL
authors: Tucker
authors: K-A
authors: KA
authors: Johansson
authors: G
authors: G
authors: Steineck
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D052801:Male Urogenital Diseases / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000453:epidemiology* / Q000209:etiology; D057566:Self Report; D011795:Surveys and Questionnaires; D017741:Survivors / Q000706:statistics & numerical data*; D013548:Sweden / Q000453:epidemiology
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