title: The association between serum progesterone and outcome of medical management of early fetal demise: a pilot study.
abstract: The study objective was to determine the relationship between serum progesterone level and the outcome of mifepristone-misoprostol regimen for medical management of missed miscarriage up to 12 weeks. A blood sample was collected just before mifepristone administration for serum progesterone assay. After 48 h, misoprostol 800 μg was administered vaginally; further 400 μg was administered 4 h later if necessary. Treatment was classed as a success if retained tissues were expelled within 72 h (Group 1), and a failure if this did not occur (Group 2). Of 52 analysed cases, complete medical evacuation occurred within 72 h in 40 (76.9%) women (serum progesterone ranged 13-90 nmol/l). Serum progesterone between the two groups were statistically significant (p < 0.001), by Mann-Whitney test. Of the 12 patients who did not respond, nine (75%) women had serum progesterone < 10 nmol/l. We found mifepristone-misoprostol regimen is less effective in missed miscarriage when serum progesterone is < 10 nmol/l.
authors: Department of Obstetrics and Gynaecology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK. asok.banerjee@uhl-tr.nhs.uk
authors: A K
authors: AK
authors: Banerjee
authors: J O
authors: JO
authors: Emembolu
authors: M
authors: M
authors: Habiba
mesh_terms: D000019:Abortifacient Agents / Q000627:therapeutic use*; D000030:Abortion, Missed / Q000097:blood / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000627:therapeutic use*; D016595:Misoprostol / Q000627:therapeutic use*; D010865:Pilot Projects; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*; D011446:Prospective Studies; D017211:Treatment Failure; D055815:Young Adult
chemical_list: D000019:Abortifacient Agents; D016595:Misoprostol; D015735:Mifepristone; D011374:Progesterone