title: Altered T-cell subsets in HIV-1 natural viral suppressors (elite controllers) with hepatitis C infection.
abstract: We have established a cohort of 64 Natural Viral Suppressors (NVS) (similar to Elite Controllers/Elite Suppressors), 30 of which have chronic hepatitis C virus (HCV). We investigated T-cell phenotypic changes in association with HCV infection. NVS without HCV and normal controls had similar T-cell phenotypes. However, NVS with HCV had lower naive cell proportions (CD4 and CD8) compared with NVS without HCV (P = 0.0008 and P = 0.02) or normal controls (P = 0.0163 and P = 0.017). These results and previously reported data suggest that HCV coinfection increases immune activation and T-cell disturbances. Any associated T-cell functional changes or potential clinical consequences need further study.
authors: Mohammad M
authors: MM
authors: Sajadi
authors: Robert R
authors: RR
authors: Redfield
authors: Rohit
authors: R
authors: Talwani
mesh_terms: D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology*; D020276:HIV Long-Term Survivors; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*
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