title: Flexible endoscope for continuous in vivo multispectral fluorescence lifetime imaging.
abstract: Fluorescence lifetime imaging (FLIM) offers a noninvasive approach for characterizing the biochemical composition of biological tissue. There has been an increasing interest in the application of multispectral FLIM for medical diagnosis. Central to the clinical translation of FLIM technology is the development of compact and high-speed endoscopy systems. Unfortunately, the predominant multispectral FLIM approaches suffer from limitations that impede the development of endoscopy systems that are suitable for in vivo tissue imaging. We present a compact wide-field time-gated FLIM flexible endoscope capable of continuous lifetime imaging of up to three fluorescence emission bands simultaneously. This endoscope design will facilitate the evaluation of FLIM for in vivo applications.
authors: Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, USA.
authors: Shuna
authors: S
authors: Cheng
authors: J Jesus
authors: JJ
authors: Rico-Jimenez
authors: Joey
authors: J
authors: Jabbour
authors: Bilal
authors: B
authors: Malik
authors: Kristen C
authors: KC
authors: Maitland
authors: John
authors: J
authors: Wright
authors: Yi-Shing Lisa
authors: YS
authors: Cheng
authors: Javier A
authors: JA
authors: Jo
mesh_terms: D000818:Animals; D002610:Cheek; D006224:Cricetinae; D019723:Endoscopes; D057054:Molecular Imaging / Q000295:instrumentation*; D013050:Spectrometry, Fluorescence
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