title: Application of combined omics platforms to accelerate biomedical discovery in diabesity.
abstract: Diabesity has become a popular term to describe the specific form of diabetes that develops late in life and is associated with obesity. While there is a correlation between diabetes and obesity, the association is not universally predictive. Defining the metabolic characteristics of obesity that lead to diabetes, and how obese individuals who develop diabetes different from those who do not, are important goals. The use of large-scale omics analyses (e.g., metabolomic, proteomic, transcriptomic, and lipidomic) of diabetes and obesity may help to identify new targets to treat these conditions. This report discusses how various types of omics data can be integrated to shed light on the changes in metabolism that occur in obesity and diabetes.
authors: Department of Medicine, Stable Isotope and Metabolomics Core Facility, Albert Einstein College of Medicine Diabetes Center, Bronx, New York 10461, USA.
authors: Irwin J
authors: IJ
authors: Kurland
authors: Domenico
authors: D
authors: Accili
authors: Charles
authors: C
authors: Burant
authors: Steven M
authors: SM
authors: Fischer
authors: Barbara B
authors: BB
authors: Kahn
authors: Christopher B
authors: CB
authors: Newgard
authors: Suma
authors: S
authors: Ramagiri
authors: Gabriele V
authors: GV
authors: Ronnett
authors: John A
authors: JA
authors: Ryals
authors: Mark
authors: M
authors: Sanders
authors: Joe
authors: J
authors: Shambaugh
authors: John
authors: J
authors: Shockcor
authors: Steven S
authors: SS
authors: Gross
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism; D015897:Comorbidity; D019295:Computational Biology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism*; D004195:Disease Models, Animal; D055808:Drug Discovery; D004734:Energy Metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism; D051379:Mice; D008875:Middle Aged; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000378:metabolism; D011236:Prediabetic State / Q000453:epidemiology / Q000378:metabolism; D015995:Prevalence; D012107:Research Design
chemical_list: D005947:Glucose
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