title: Nodular sclerosing adenosis of breast: A diagnostic pitfall in fine needle aspiration cytology.
abstract: Fine needle aspiration cytology was performed in a 46-year-old female presenting with a breast lump and mammography suggesting a malignancy. The smears were cellular with cohesive clusters and scattered epithelial cells showing moderate nuclear pleomorphism and focal acinar formation. Stromal fragments, benign epithelial cell clusters and a few naked nuclei were noted in the background. Considering the clinical features, mammography findings as well as cytological features, a diagnosis of ductal carcinoma was suggested. Subsequent histopathological examination revealed it to be nodular sclerosing adenosis. The cytohistological correlation of this uncommon lesion, a potential pitfall in breast fine needle aspiration diagnosis which may lead to a false-positive diagnosis is discussed.
authors: Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors: S
authors: S
authors: Sreedharanunni
authors: A
authors: A
authors: Das
authors: S
authors: S
authors: Veenu
authors: R
authors: R
authors: Srinivasan
authors: G
authors: G
authors: Singh
keywords: Breast fine needle aspiration; ductal carcinoma; false-positive diagnosis; fine needle aspiration cytology; nodular sclerosing adenosis; proliferative breast disease
references: Histopathology. 1987 Dec;11(12):1259-75
references: 2831132
references: Acta Cytol. 2001 May-Jun;45(3):353-9
references: 11393066
references: Cancer. 1989 Nov 15;64(10):1977-83
references: 2804888
references: Acta Cytol. 1989 Mar-Apr;33(2):181-7
references: 2929218
references: Arch Pathol Lab Med. 2008 Sep;132(9):1439-41
references: 18788857
references: Diagn Cytopathol. 2008 Jul;36(7):496-8
references: 18528894
references: Breast J. 2003 May-Jun;9(3):255-6
references: 12752642
references: Indian J Pathol Microbiol. 2000 Apr;43(2):131-4
references: 11217268