title: Optimization of [(11)C]raclopride positron emission tomographic rat studies: comparison of methods for image quantification.
abstract: The goal of this study was to compare different quantification approaches and reconstruction methods to estimate the binding potential in [11C]raclopride studies in rats. The final aim was to determine if the results obtained with short-acquisition scanning were comparable to the results obtained with long-acquistion (conventional) scanning. We analyzed two rat data sets: a baseline versus a pretreatment study (with cold raclopride) and a young versus an old animal group comparison. The study results support the contention that optimization of [11C]raclopride positron emission tomographic studies in rats by shortening the acquisition time is feasible. In addition, filtered backprojection is recommended as a reconstruction algorithm, although iterative methods may be more sensitive to detect within-group differences.
authors: Elia
authors: E
authors: Torrent
authors: Magí
authors: M
authors: Farré
authors: Ibane
authors: I
authors: Abasolo
authors: Olga
authors: O
authors: Millan
authors: Jordi
authors: J
authors: Llop
authors: Juan Domingo
authors: JD
authors: Gispert
authors: Alba
authors: A
authors: Ruiz
authors: Deborah
authors: D
authors: Pareto
mesh_terms: D000818:Animals; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D020891:Raclopride; D011854:Radiochemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D020891:Raclopride