title: Parathyroid hormone-related protein and regulation of cell survival in the kidney.
abstract: Parathyroid hormone-related protein (PTHrP) is a pleiotropic factor with multiple physiological functions in morphogenesis, cell proliferation, differentiation, apoptosis, and calcium homeostasis. In the kidney, PTHrP is known to be expressed abundantly and to be upregulated in various experimental nephropathies, showing growth-modulatory and proinflammatory properties. Ardura et al. demonstrate a possible link between PTHrP-induced Runx2 expression and an antiapoptotic effect in tubular epithelial cells.
authors: Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.
authors: Rafael
authors: R
authors: Kramann
authors: Rebekka K
authors: RK
authors: Schneider
mesh_terms: D000818:Animals; D017209:Apoptosis; D050659:Core Binding Factor Alpha 1 Subunit / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D044162:Parathyroid Hormone-Related Protein / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*
chemical_list: D050659:Core Binding Factor Alpha 1 Subunit; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments; C493709:RUNX2 protein, human; C493716:Runx2 protein, mouse; C079957:parathyroid hormone-related peptide (1-36)