title: Ipsilateral motor pathways after stroke: implications for non-invasive brain stimulation.
abstract: In humans the two cerebral hemispheres have essential roles in controlling the upper limb. The purpose of this article is to draw attention to the potential importance of ipsilateral descending pathways for functional recovery after stroke, and the use of non-invasive brain stimulation (NBS) protocols of the contralesional primary motor cortex (M1). Conventionally NBS is used to suppress contralesional M1, and to attenuate transcallosal inhibition onto the ipsilesional M1. There has been little consideration of the fact that contralesional M1 suppression may also reduce excitability of ipsilateral descending pathways that may be important for paretic upper limb control for some patients. One such ipsilateral pathway is the cortico-reticulo-propriospinal pathway (CRPP). In this review we outline a neurophysiological model to explain how contralesional M1 may gain control of the paretic arm via the CRPP. We conclude that the relative importance of the CRPP for motor control in individual patients must be considered before using NBS to suppress contralesional M1. Neurophysiological, neuroimaging, and clinical assessments can assist this decision making and facilitate the translation of NBS into the clinical setting.
authors: Brain Research Laboratory, Centre for Neuroscience, School of Medicine, Flinders University Adelaide, SA, Australia ; Effectiveness of Therapy Group, Centre for Clinical Change and Healthcare Research, School of Medicine, Flinders University Adelaide, SA, Australia.
authors: Lynley V
authors: LV
authors: Bradnam
authors: Cathy M
authors: CM
authors: Stinear
authors: Winston D
authors: WD
authors: Byblow
keywords: propriospinal; rehabilitation; stroke; transcranial direct current stimulation; upper limb
references: J Neurophysiol. 2005 Mar;93(3):1209-22
references: 15525809
references: Neuroscientist. 2009 Oct;15(5):436-44
references: 19826168
references: Stroke. 2005 Dec;36(12):2681-6
references: 16254224
references: J Neurophysiol. 2004 Jul;92(1):83-95
references: 15014106
references: Stroke. 2001 Jun;32(6):1304-9
references: 11387491
references: J Neurophysiol. 2008 Oct;100(4):2109-14
references: 18715892
references: Exp Neurol. 2011 Jul;230(1):149-55
references: 21524650
references: Brain Stimul. 2008 Oct;1(4):370-82
references: 20633395
references: Brain. 2008 May;131(Pt 5):1381-90
references: 18356189
references: Clin Neurophysiol. 2007 Sep;118(9):2050-62
references: 17644036
references: Ann Neurol. 1997 Feb;41(2):247-54
references: 9029074
references: Cereb Cortex. 2011 Apr;21(4):756-68
references: 20801897
references: Exp Brain Res. 1977 Sep 28;29(3-4):323-46
references: 913521
references: Neuroimage. 2010 Mar;50(1):233-42
references: 20005962
references: J Physiol. 1998 Jul 1;510 ( Pt 1):249-59
references: 9625881
references: Brain. 1997 Sep;120 ( Pt 9):1579-86
references: 9313641
references: J Neurophysiol. 2011 Jun;105(6):2937-42
references: 21511707
references: Lancet Neurol. 2010 Dec;9(12):1228-1232
references: 21035399
references: Brain. 2011 May;134(Pt 5):1264-76
references: 21414995
references: Brain Res. 2013 Apr 4;1504:58-73
references: 23396112
references: Clin Neurophysiol. 2000 Oct;111(10):1860-7
references: 11018503
references: Brain Res. 2011 Jan 31;1371:65-73
references: 21093420
references: Neurosci Lett. 2011 Jan 13;488(1):22-5
references: 21056628
references: Cereb Cortex. 2012 Nov;22(11):2662-71
references: 22139791
references: Science. 2007 Nov 16;318(5853):1150-5
references: 18006750
references: Neuroreport. 2005 Sep 28;16(14):1551-5
references: 16148743
references: J Neurosci. 2007 Jul 25;27(30):8053-8
references: 17652596
references: Exp Brain Res. 1981;42(3-4):269-81
references: 7238671
references: Clin Neurophysiol. 2003 Apr;114(4):605-13
references: 12686269
references: Brain. 2007 Jan;130(Pt 1):170-80
references: 17148468
references: Ann Neurol. 2008 Feb;63(2):236-46
references: 17896791
references: Exp Neurol. 2008 Jun;211(2):407-12
references: 18395715
references: Eur J Neurosci. 2007 Mar;25(6):1865-73
references: 17432972
references: Neurosci Lett. 1976 Dec;3(5-6):245-52
references: 19604894
references: Cereb Cortex. 2010 Jan;20(1):169-86
references: 19561063
references: Acta Physiol (Oxf). 2007 Feb;189(2):123-40
references: 17250564
references: Brain. 2006 Mar;129(Pt 3):809-19
references: 16421171
references: Restor Neurol Neurosci. 2006;24(3):191-9
references: 16873974
references: Cortex. 2009 Oct;45(9):1065-71
references: 19243741
references: Stroke. 2010 Jul;41(7):1568-72
references: 20489170
references: J Rehabil Med. 2011 Apr;43(5):430-4
references: 21403983
references: Exp Brain Res. 2003 Jan;148(2):176-85
references: 12520405
references: Brain. 2003 Jun;126(Pt 6):1430-48
references: 12764063
references: Clin Neurophysiol. 2000 Nov;111(11):1990-6
references: 11068234
references: J Clin Neurophysiol. 2004 Nov-Dec;21(6):426-34
references: 15622129
references: Restor Neurol Neurosci. 2007;25(2):123-9
references: 17726271
references: Brain. 2009 Mar;132(Pt 3):709-21
references: 19155271
references: Exp Brain Res. 2004 May;156(1):72-9
references: 14689132
references: Brain Res. 2004 Aug 13;1017(1-2):172-83
references: 15261113
references: Arch Neurol. 2008 Jun;65(6):741-7
references: 18541794
references: J Neurol Sci. 2010 Mar 15;290(1-2):107-11
references: 19914639
references: Electroencephalogr Clin Neurophysiol. 1996 Aug;101(4):316-28
references: 8761041
references: J Neurophysiol. 2006 Jun;95(6):3674-85
references: 16495365
references: Neurology. 2005 May 24;64(10):1802-4
references: 15911819
references: Brain. 2012 Jul;135(Pt 7):2277-89
references: 22581799
references: Stroke. 2010 Oct;41(10 Suppl):S114-6
references: 20876483
references: J Neurosci. 2006 May 31;26(22):6096-102
references: 16738254
references: J Physiol. 2008 Sep 15;586(18):4489-500
references: 18669534
references: Am J Phys Med Rehabil. 2010 Nov;89(11):879-86
references: 20962598
references: J Physiol. 2010 Jan 1;588(Pt 1):201-12
references: 19917563
references: Brain. 2002 Aug;125(Pt 8):1896-907
references: 12135979
references: Cereb Cortex. 2007 Feb;17(2):353-62
references: 16525129
references: J Neurol Sci. 1973 Feb;18(2):217-26
references: 4347866
references: Exp Brain Res. 2006 Aug;173(1):25-39
references: 16506008
references: Ann Neurol. 2009 Sep;66(3):298-309
references: 19798637
references: Brain. 1973 Dec;96(4):653-74
references: 4204228
references: J Physiol. 2011 Jun 1;589(Pt 11):2813-26
references: 21502292
references: Annu Rev Neurosci. 2008;31:195-218
references: 18558853
references: Cereb Cortex. 2008 Jun;18(6):1395-406
references: 17928331
references: Ann Neurol. 2004 Mar;55(3):400-9
references: 14991818
references: Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14518-23
references: 12376621
references: Can J Physiol Pharmacol. 1996 Apr;74(4):518-30
references: 8828897
references: Brain. 2003 Apr;126(Pt 4):988-1000
references: 12615654
references: J Neurophysiol. 2011 May;105(5):2582-9
references: 21389299
references: Eur J Neurol. 2008 Jul;15(7):706-11
references: 18484986
references: J Physiol. 2007 Aug 1;582(Pt 3):1361-79
references: 17510184
references: J Neurophysiol. 2012 Jan;107(2):532-43
references: 22031772
references: Brain. 2012 Jan;135(Pt 1):276-84
references: 22155982
references: J Neurosci. 2008 May 28;28(22):5631-40
references: 18509024
references: Stroke. 2011 Feb;42(2):421-6
references: 21164128
references: Exp Brain Res. 1984;56(2):308-22
references: 6479264
references: Brain. 1993 Apr;116 ( Pt 2):369-82
references: 8461971
references: Neurorehabil Neural Repair. 2012 Oct;26(8):976-87
references: 22412171
references: Clin Neurophysiol. 2000 Feb;111(2):344-9
references: 10680571
references: Clin Neurophysiol. 2012 May;123(5):1027-34
references: 22014699
references: Brain. 2012 Aug;135(Pt 8):2527-35
references: 22689909
references: Prog Brain Res. 1964;11:178-202
references: 14300477
references: J Neurophysiol. 2010 Nov;104(5):2594-602
references: 20844109