title: Noninvasive pH Monitoring in Platelet Concentrates.
abstract: BACKGROUND
  New technology introduces the option to measure pH in platelet concentrates noninvasively. Findings that in one out of 25 apheresis concentrates the pH decreased significantly during storage motivated us to evaluate apheresis concentrates from 307 platelet donors.
  
  
  METHODS
  Small (15 ml) BSCI storage containers for noninvasive pH measurement were used in parallel with Fenwal PL2400 bags for storage of 5 days. Noninvasive pH measurement was compared to pH determination in samples from the storage container. Decrease of pH during storage was calculated as ΔpH d2-d5.
  
  
  RESULTS
  The coefficient of correlation for noninvasive pH measurement (n = 256) versus standard methods was R(2) = 0.964 (pH electrode) or 0.952 (ABL 510). pH values in BSCI bags were slightly lower than in Fenwal PL2400 containers. Concentrates collected from 8 of the 307 donors showed a significant drop in pH. Repeated collection did not confirm these findings with a single exception.
  
  
  CONCLUSIONS
  Noninvasive pH measurement demonstrates a high reproducibility. Our study could not confirm the frequency of 1 out of 25 plateletpheresis donors with concentrates developing a significant drop in pH during storage. This may be due to a substantially lower platelet concentration in our preparations.
authors: DRK-Blutspendedienst NSTOB, Institut Bremen-Oldenburg, Oldenburg, Springe, Germany.
authors: Andrea
authors: A
authors: Doescher
authors: Thomas H
authors: TH
authors: Müller
keywords: Donor screening; Noninvasive pH measurement; Platelet concentrates
references: Transfus Med Rev. 1994 Jan;8(1):29-36
references: 8136605
references: Transfusion. 1975 Sep-Oct;15(5):414-21
references: 823
references: Vox Sang. 1997;73(2):74-80
references: 9304775
references: Transfusion. 2009 Jun;49(6):1233-41
references: 19290994
references: Transfusion. 2006 Aug;46(8):1300-5
references: 16934063
references: Scand J Haematol. 1985 Aug;35(2):229-32
references: 4048869
references: Transfusion. 2010 Oct;50(10):2185-92
references: 20456693
references: Blood. 1982 Jul;60(1):194-200
references: 7082838