title: Expression quantitative trait loci: present and future.
abstract: The last few years have seen the development of large efforts for the analysis of genome function, especially in the context of genome variation. One of the most prominent directions has been the extensive set of studies on expression quantitative trait loci (eQTLs), namely, the discovery of genetic variants that explain variation in gene expression levels. Such studies have offered promise not just for the characterization of functional sequence variation but also for the understanding of basic processes of gene regulation and interpretation of genome-wide association studies. In this review, we discuss some of the key directions of eQTL research and its implications.
authors: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva 1211, Switzerland.
authors: Alexandra C
authors: AC
authors: Nica
authors: Emmanouil T
authors: ET
authors: Dermitzakis
mesh_terms: D002877:Chromosomes, Human / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D005787:Gene Frequency; D053263:Gene Regulatory Networks; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D012045:Regulatory Sequences, Nucleic Acid
keywords: expression quantitative trait loci; genetics; regulation
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