title: Multiscale stochastic reaction-diffusion modeling: application to actin dynamics in filopodia.
abstract: Two multiscale (hybrid) stochastic reaction-diffusion models of actin dynamics in a filopodium are investigated. Both hybrid algorithms combine compartment-based and molecular-based stochastic reaction-diffusion models. The first hybrid model is based on the models previously developed in the literature. The second hybrid model is based on the application of a recently developed two-regime method (TRM) to a fully molecular-based model, which is also developed in this paper. The results of hybrid models are compared with the results of the molecular-based model. It is shown that both approaches give comparable results, although the TRM model better agrees quantitatively with the molecular-based model.
authors: Mathematical Institute, University of Oxford, 24-29 St. Giles', Oxford, OX1 3LB, UK, erban@maths.ox.ac.uk.
authors: Radek
authors: R
authors: Erban
authors: Mark B
authors: MB
authors: Flegg
authors: Garegin A
authors: GA
authors: Papoian
mesh_terms: D000199:Actins / Q000502:physiology*; D000465:Algorithms; D003198:Computer Simulation; D008954:Models, Biological; D011554:Pseudopodia / Q000502:physiology*; D013269:Stochastic Processes
chemical_list: D000199:Actins