title: Therapeutic strategies for tendon healing based on novel biomaterials, factors and cells.
abstract: The repair of tendon injuries still presents a major clinical challenge to orthopedic medicine. Tendons, like some other tissues, are poorly vascularized and heal slowly. In addition, healing often leads to the formation of fibrous tissue and scar tissue which lack flexibility and biomechanical properties. So the treatment of tendon injuries is challenging. We give an overview of the structure and composition of tendons, pathological states of tendon and natural healing, as well as therapeutic options. We focus in particular on biomaterials that have been specifically developed or suggested for the successful repair of tendon injuries. In addition, we also review factor- and cell-dependent strategies to heal tendon and ligament disorders. Although brief, we hope that this review will be helpful, particularly for those readers who are new to the field of tendon tissue engineering.
authors: Department of Molecular Biotechnology, Signalling and Gene Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.
authors: Gerhard
authors: G
authors: Gross
authors: Andrea
authors: A
authors: Hoffmann
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use*; D001696:Biomechanical Phenomena; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D008022:Ligaments / Q000473:pathology / Q000502:physiology*; D012038:Regeneration; D013708:Tendon Injuries / Q000473:pathology / Q000628:therapy*; D013710:Tendons / Q000473:pathology / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials