title: Development of gelatin flakes, a new type of anti-adhesive material: a preliminary study of in vivo rat adhesion models.
abstract: To overcome the problems associated with sheet- or film-type anti-adhesive materials, we developed a new type of anti-adhesive material, gelatin flakes. We made two types of gelatin flakes with or without thermal cross-linking, and preliminarily examined their basic properties and the anti-adhesive efficacy using a rodent adhesion model. Both types of the gelatin flakes rapidly turned into gel and tightly attached the injured surfaces, absorbing the moisture and blood, when applied onto the abraded sites of rats. In addition, these flakes could be sprayed into the desired area by compressed air through a device with a long, thin tube, which could be used in laparoscopic surgery. The anti-adhesive effects of both types of gelatin flakes were similar, and both types were significantly superior compared to the non-treated group. Although further investigations are necessary, the gelatin flakes have unique and useful properties and satisfactory anti-adhesive effects, which indicate that they may be applicable in laparoscopic surgery.
authors: Division of Medical Life System, Department of Life and Medical Science, Doshisha University, 1-3 Tatara-Miyakodani, Kyotanabe, Kyoto, 610-0321, Japan, sk108621@mail.doshisha.ac.jp.
authors: Hiroyuki
authors: H
authors: Tsujimoto
authors: Hideki
authors: H
authors: Takamori
authors: Misaki
authors: M
authors: Tsuji
authors: Maho
authors: M
authors: Hayashi
authors: Junki
authors: J
authors: Ikeda
authors: Taichi
authors: T
authors: Orikasa
authors: Hiroko
authors: H
authors: Torii
authors: Yuki
authors: Y
authors: Ozamoto
authors: Shuko
authors: S
authors: Suzuki
authors: Shinichiro
authors: S
authors: Morita
authors: Yoshito
authors: Y
authors: Ikada
authors: Akeo
authors: A
authors: Hagiwara
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D004195:Disease Models, Animal; D015195:Drug Design; D005260:Female; D005780:Gelatin; D010535:Laparoscopy; D011208:Powders; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D001672:Biocompatible Materials; D011208:Powders; D005780:Gelatin
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