title: Infiltrating gastric adenocarcinoma with disseminated osteoblastic metastases.
abstract: We report the case of a man with a diagnosis of invasive gastric adenocarcinoma associated with scattered osteoblastic metastases. This 65-year-old patient was admitted with nausea, vomiting and abdominal pain, in addition to loss of weight (13 Kg in 3 months). Upper digestive endoscopy revealed extensive infiltrating changes in the body of the stomach, and histopathologic data confirmed the diagnosis of a Borrmann IV gastric adenocarcinoma. Complementary exams were indicative of a gastric cancer with bone metastases, characterized by disseminated osteoblastic images of the scintigraphy of the skeleton. Palliative chemotherapy was the treatment of first choice. High serum levels of CA 19-9, CEA and alkaline phosphatase can constitute useful indicative tools of this challenging condition. Images from a scintigraphy study of the skeleton can characterize the type and extension of bone metastases. The aim of this case study is to report a case of a very uncommon condition, considering that disseminated osteoblastic metastases rarely develop in this kind of tumor.
authors: Armed Forces Hospital, Cruzeiro Novo, Brasilia, Brasil. vitorinomodestos@gmail.com
authors: V M
authors: VM
authors: Santos
authors: T A
authors: TA
authors: Vieira
authors: C S
authors: CS
authors: Marinho
authors: T P
authors: TP
authors: Loures
authors: B B V
authors: BB
authors: Brandao
authors: R N
authors: RN
authors: Botan
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary*; D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology* / Q000556:secondary*; D006801:Humans; D008297:Male; D010006:Osteoblasts / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology*