title: Natriuria and calciuria levels in preeclampsia: a cross-sectional study.
abstract: OBJECTIVE
  Sodium excretion abnormalities in preeclampsia have been studied in relation to several factors. The objective of this study was to compare natriuria (mEq/24 h) and calciuria levels (mg/24 h) in preeclamptic patients.
  
  
  METHODS
  An analytical cross-sectional study with a control group was conducted in the obstetric center and the high-risk pregnancy outpatient clinic at a university hospital in southern Brazil, and in a primary healthcare unit in the same city, including pregnant women with mild preeclampsia, severe preeclampsia or chronic hypertension, and women with normal pregnancies (14 patients in each group).
  
  
  METHODS
  Natriuria was measured using an ion-selective electrode in an automated clinical chemistry analyzer (Hitache 917, Roche). All the patients collected 24-hour urine, at home or at the hospital, for analysis of proteins, creatinine, calcium, sodium and uric acid. Quantitative variables with asymmetrical distribution were described using the median, minimum and maximum, and were compared using the Kruskal-Wallis test. The results were logarithmically transformed, with one-way analysis of variance (ANOVA) by ranks and then the post-hoc Tukey test, and were analyzed by means of the Spearman correlation and receiver operating characteristic (ROC) curve. The significance level used was 0.05.
  
  
  RESULTS
  There were significant differences between the groups in comparing severe preeclampsia with chronic hypertension and severe preeclampsia with controls (P < 0.0001 for both measurements).
  
  
  CONCLUSIONS
  Natriuria levels may be lower in preeclampsia when associated with calciuria. Natriuria assessment is an additional test for differential diagnosis of hypertensive diseases in pregnancy, but is a poor predictor when used alone.
authors: Postgraduate Program in Medicine: Medical Sciences, Department of Obstetrics and Gynecology, School of Medicine, Universidade Federal do Rio Grande do Sul UFRGS. gasnier.rose@gmail.com
authors: Rose
authors: R
authors: Gasnier
authors: Edimárlei Gonsales
authors: EG
authors: Valério
authors: Janete
authors: J
authors: Vettorazzi
authors: Sérgio Hoffmeister
authors: SH
authors: Martins-Costa
authors: Elvino Guardão
authors: EG
authors: Barros
authors: José Geraldo Lopes
authors: JG
authors: Ramos
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine; D002118:Calcium / Q000652:urine*; D003937:Diagnosis, Differential; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000652:urine*; D011247:Pregnancy; D012964:Sodium / Q000652:urine*
chemical_list: D015415:Biomarkers; D012964:Sodium; D002118:Calcium
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