title: The role of anticoagulants, antiplatelet agents, and their reversal strategies in the management of intracerebral hemorrhage.
abstract: New anticoagulant and antiplatelet medications have been approved and are prescribed with increased frequency. Intracranial hemorrhage is associated with the use of these medications. Therefore, neurosurgeons need to be aware of these new medications, how they are different from their predecessors, and the strategies for the urgent reversal of their effects. Utilization of intraluminal stents by endovascular neurosurgeons has resulted in the need to have a thorough understanding of antiplatelet agents. Increased use of dabigatran, rivaroxaban, and apixaban as oral anticoagulants for the treatment of atrial fibrillation and acute deep venous thrombosis has increased despite the lack of known antidotes to these medications.
authors: Division of Neurosurgery, Department of Surgery, East Carolina University Brody School of Medicine, Greenville, North Carolina, USA. jamesro@ecu.edu
authors: Robert F
authors: RF
authors: James
authors: Viktoras
authors: V
authors: Palys
authors: Jason R
authors: JR
authors: Lomboy
authors: J Richard
authors: JR
authors: Lamm
authors: Scott D
authors: SD
authors: Simon
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D002543:Cerebral Hemorrhage / Q000628:therapy*; D006801:Humans; D019635:Neurosurgical Procedures / Q000379:methods; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D014812:Vitamin K / Q000008:administration & dosage
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D014812:Vitamin K