title: Novel therapeutic agents in clinical development for systemic lupus erythematosus.
abstract: Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with considerable toxicity and a substantial proportion of patients remain refractory to treatment. A more comprehensive understanding of the complexity of SLE immunopathogenesis has evolved over the past decade and has led to the testing of several biologic agents in clinical trials. There is a clear need for new therapeutic agents that overcome these issues, and biologic agents offer exciting prospects as future SLE therapies.An array of promising new therapies are currently emerging or are under development including B-cell depletion therapies, agents targeting B-cell survival factors, blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonal antibodies against interleukin-6 and interferon-α.
authors: Louise Coote Lupus Unit, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK.
authors: Natasha
authors: N
authors: Jordan
authors: Pamela M K
authors: PM
authors: Lutalo
authors: David P
authors: DP
authors: D'Cruz
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D001685:Biological Factors / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000639:trends; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*
chemical_list: D020533:Angiogenesis Inhibitors; D001685:Biological Factors; D007166:Immunosuppressive Agents
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