title: Tumor suppressor role of notch1 and raf-1 signaling in medullary thyroid cancer cells.
abstract: There is a growing body of literature suggesting that signaling based therapy might be a potential approach for medullary thyroid cancer (MTC). In this review we focus on the tumor suppressor role of Notch1 and Raf-1 signaling in MTC. Interestingly these two pathways are minimally active or absent in these tumors and activation of Notch1 and Raf-1 significantly reduces tumor growth in vitro. Therefore, identification of compounds that induce these pathways could be a potential strategy to treat patients with MTC.
authors: Endocrine Surgery Research Laboratories, Section of Endocrine Surgery, Department of Surgery, The University of Wisconsin, and the University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, WI, U.S.A.
authors: Muthusamy
authors: M
authors: Kunnimalaiyaan
authors: Megan R
authors: MR
authors: Haymart
authors: Herbert
authors: H
authors: Chen
keywords: Notch1; Notch1 activating compound; Raf-1; ZM336372; achaete scute complex-like 1; medullary thyroid cancer
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