title: [Pulmonary expression levels of fibroblast growth factor receptors and lung fibrosis in mice at different ages].
abstract: OBJECTIVE
  To explore the correlation of pulmonary expressions of fibroblast growth factor receptors (FGFR1-4) with lung fibrosis and aging.
  
  
  METHODS
  Real-time fluorescence quantitative PCR was used to detect the expression levels of FGFR1-4 in the lung tissues, and lung fibrosis was observed by HE and Masson staining in mice at different ages.
  
  
  RESULTS
  The 4 subtypes of FGFR showed different expression levels in the lung tissues of mice, and FGFR2 had the highest expressions. The expression levels of all the 4 FGFR subtypes in 8-month-old mice were significantly lower than those in 5-week-old mice. The 8-month-old mice tended to present with histological changes of lung fibrosis.
  
  
  CONCLUSIONS
  FGFR expressions is down-regulated with aging in mice. Among the FGFR subtypes, FGFR2 is expressed at the highest level. The occurrence of lung fibrosis with aging is probably associated with down-regulated FGFR expression. FGF/FGFR signaling may participate in the aging process and regulation of lung fibrosis.
authors: Health Management Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. itscice@163.com
authors: Xiaoxi
authors: X
authors: Li
authors: Hongen
authors: H
authors: Chang
authors: Wenqing
authors: W
authors: Nai
authors: Xiaoyan
authors: X
authors: Bai
authors: Ying
authors: Y
authors: Sun
authors: Yanlin
authors: Y
authors: Yu
authors: Meng
authors: M
authors: Dai
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011658:Pulmonary Fibrosis / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D017468:Receptors, Fibroblast Growth Factor / Q000145:classification / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017468:Receptors, Fibroblast Growth Factor