title: Investigation of APOE isoforms and the association between APOE E3 and E4 with migraine in the Australian Caucasian population.
abstract: Migraine is a debilitating neurovascular disease that is associated with pulsating head pain accompanied by nausea, vomiting, photophobia, phonophobia and sometimes visual sensory disturbances. Because of its role in nitric oxide regulation and interleukin release, apolipoprotein E (APOE) has been suggested to play a role in the migraine pathogenesis pathway. This study evaluated the potential role of three APOE variants in an Australian population and the role that they may play in susceptibility to migraine. The study found no significant association between the tested variants and migraine for any of the APOE variants investigated.
authors: School of Medical Science, Genomics Research Centre, Griffith Health Institute, Griffith University, Queensland, Australia.
authors: Shani
authors: S
authors: Stuart
authors: Bianca
authors: B
authors: Donges
authors: Melanie
authors: M
authors: Murrell
authors: Larisa M
authors: LM
authors: Haupt
authors: Rod A
authors: RA
authors: Lea
authors: Lyn R
authors: LR
authors: Griffiths
mesh_terms: D000328:Adult; D000483:Alleles; D053329:Apolipoprotein E2 / Q000737:chemistry / Q000235:genetics; D053318:Apolipoprotein E3 / Q000737:chemistry / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000737:chemistry / Q000235:genetics*; D001315:Australia / Q000453:epidemiology; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000453:epidemiology / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D044465:White People
chemical_list: D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D004247:DNA