title: Treatment of peri-implantitis using nonsurgical debridement with bioresorbable nanospheres for controlled release of doxycycline: case report.
abstract: Peri-implantitis treatment is often surgical; however, in this case report, an alternative approach has been documented using a combination of nonsurgical debridement with the local controlled release of doxycycline by bioresorbable nanospheres in the peri-implant defect. After 15 months, remission on clinical inflammatory parameters of bleeding and suppuration on probing, as well as reduction of probing depths, was observed. This alternative approach may enhance clinical parameter improvements in some cases of peri-implantitis without the need for a surgical approach for implant decontamination.
authors: Department of Prosthodontics and Periodontics, Division of Periodontics, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
authors: Lucas Alves
authors: LA
authors: Moura
authors: Ana Paula
authors: AP
authors: Oliveira Giorgetti Bossolan
authors: Eliana Aparecida
authors: EA
authors: de Rezende Duek
authors: Enilson Antonio
authors: EA
authors: Sallum
authors: Francisco Humberto
authors: FH
authors: Nociti
authors: Márcio Zaffalon
authors: MZ
authors: Casati
authors: Antonio Wilson
authors: AW
authors: Sallum
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D018441:Biofilms / Q000187:drug effects; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations; D003773:Dental Plaque / Q000517:prevention & control; D004318:Doxycycline / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000188:drug therapy / Q000628:therapy; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D054118:Nanospheres / Q000008:administration & dosage* / Q000737:chemistry; D057873:Peri-Implantitis / Q000188:drug therapy / Q000628:therapy*; D057747:Periodontal Debridement / Q000295:instrumentation / Q000379:methods*; D010514:Periodontal Pocket / Q000188:drug therapy / Q000628:therapy; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004318:Doxycycline