title: Variants of cardiomyopathy and hypertension in neuroblastoma.
abstract: Catecholamine-associated cardiomyopathies caused by neuroblastoma have rarely been reported. We are reporting 2 cases of neuroblastoma associated with hypertension and severe cardiomyopathic changes in different extremes. One case was dilated cardiomyopathy with heart failure, and the other showed echocardiographic features simulating hypertrophic obstructive cardiomyopathy. Both girls had high levels of urine catecholamines on presentation. Anthracycline group of chemotherapy was avoided. Chemotherapy and tumor resection resulted in successful normalization of blood pressure and regression of cardiomyopathic changes. Blood pressure and cardiomyopathic changes should be monitored not only at presentation, but also during the treatment for neuroblastoma.
authors: Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
authors: Sit Yee
authors: SY
authors: Kwok
authors: Frankie Wai Tsoi
authors: FW
authors: Cheng
authors: Amy Fung Cheung
authors: AF
authors: Lo
authors: Wing Kwan
authors: WK
authors: Leung
authors: Man Ching
authors: MC
authors: Yam
authors: Chi Kong
authors: CK
authors: Li
mesh_terms: D001794:Blood Pressure; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D002395:Catecholamines / Q000652:urine; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D006333:Heart Failure; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D007223:Infant; D009447:Neuroblastoma / Q000150:complications* / Q000378:metabolism; D011379:Prognosis
chemical_list: D002395:Catecholamines