title: [Clinical research of timing of application of antibiotics in septic shock of pediatric patients].
abstract: OBJECTIVE
  To investigate the value of timing of antibiotics in pediatric septic shock.
  
  
  METHODS
  Eighty children with septic shock treated with bundle treatment in Department of Critical Care Medicine were retrospectively analyzed. Eighty children with septic shock were divided into observation group (n=40, anti-infection therapy within 1 hour after admission) and control group (n=40, anti-infection therapy 1-6 hours after admission). The contents of lactate, C-reaction protein (CRP) and procalcitonin (PCT) were compared between two groups at admission and 24 hours and 72 hours after admission.
  
  
  RESULTS
  Lactate in the observation group was significantly lower than that of the control group within the first 24 hours after admission (8.65 ± 2.84 mmol/L vs. 11.75 ± 3.20 mmol/L, P<0.01). CRP in the observation group was significantly lower than that of the control group 24 hours and 72 hours after admission (66.25 ± 8.55 mg/L vs. 91.77 ± 7.71 mg/L, 22.03 ± 7.46 mg/L vs. 50.11 ± 7.30 mg/L, both P<0.01). PCT in the observation group was significantly lower than that of the control group 72 hours after admission (0.67 ± 0.31 μg/L vs. 1.16 ± 0.25 μg/L, P<0.01). Time for shock recovery in the observation group was significantly shorter than that of the control group (6.80 ± 3.70 hours vs. 12.80 ± 3.63 hours, P<0.05), but no statistical difference in mortality rate between groups was found [5% (2/40) vs. 10% (4/40), P>0.05].
  
  
  CONCLUSIONS
  With the early empirical anti-infection treatment in pediatric septic shocked patients, time for recovery from shock can be shortened and successful rate of resuscitation can be improved.
authors: Department of Critical Care Medicine, Hebei Provincial Children's Hospital, Shijiazhuang 050031, Hebei, China.
authors: Xiao-dong
authors: XD
authors: Wang
authors: Xi-min
authors: XM
authors: Huo
authors: Mei-xian
authors: MX
authors: Xu
authors: Wen-jin
authors: WJ
authors: Geng
authors: Yan-mei
authors: YM
authors: Guo
authors: Li-jing
authors: LJ
authors: Cao
authors: Hui
authors: H
authors: Sun
authors: Xiao-na
authors: XN
authors: Shi
authors: Jun-E
authors: JE
authors: Li
authors: Hai-yan
authors: HY
authors: Shi
authors: Pan
authors: P
authors: Li
authors: Lei
authors: L
authors: Kang
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000378:metabolism; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D002648:Child; D002675:Child, Preschool; D003422:Critical Care; D005260:Female; D006801:Humans; D007223:Infant; D019344:Lactic Acid / Q000097:blood; D008297:Male; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood; D012772:Shock, Septic / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; C000606589:CALCA protein, human; D011498:Protein Precursors; D019344:Lactic Acid; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide