title: A new parameter predicting chronic total occlusion of coronary arteries: platelet distribution width.
abstract: Platelet distribution width (PDW) measures the variability in platelet size and is a marker of platelet activation. We investigated whether PDW is associated with the extent of coronary artery disease (CAD) and coronary total occlusions (CTOs). We studied 162 patients: 108 had a coronary lesion with a diameter stenosis of ≥50%, the CAD(+) group, and 54 patients had normal coronary anatomy, the CAD(-) group. The CAD(+) group was subdivided into CAD(+) CTO(+) and CAD(+) CTO(-) groups. Among patients with CAD, the CTO(+) group had a significantly greater PDW (%) than the CTO(-) group (16.9 ± 2.8, 15.4 ± 3.0, and 15.4 ± 1.9, respectively; P = .008). In a receiver-operating characteristic analysis, a PDW cut point of 15.7% was identified in patients with CTO(+) (area under curve = 0.64, 95% confidence interval 0.54-0.75). A PDW value of more than 15.7% demonstrated a sensitivity of 64% and a specificity of 66%. The PDW is a simple platelet index that may predict the presence of CTO.
authors: 1Department of Cardiology, Faculty of Medicine, BezmiAlem Vakif University, Istanbul, Turkey.
authors: Mehmet Akif
authors: MA
authors: Vatankulu
authors: Osman
authors: O
authors: Sonmez
authors: Gokhan
authors: G
authors: Ertas
authors: Ahmet
authors: A
authors: Bacaksiz
authors: Murat
authors: M
authors: Turfan
authors: Ercan
authors: E
authors: Erdogan
authors: Abdurrahman
authors: A
authors: Tasal
authors: Seref
authors: S
authors: Kul
authors: Huseyin
authors: H
authors: Uyarel
authors: Omer
authors: O
authors: Goktekin
mesh_terms: D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000473:pathology*; D017023:Coronary Angiography; D054059:Coronary Occlusion / Q000097:blood*; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity
keywords: coronary artery disease; platelet distribution width; total occlusion