title: The ACACA and SREBF1 genes are promising markers for pig carcass and performance traits, but not for fatty acid content in the longissimus dorsi muscle and adipose tissue.
abstract: Among functional and positional candidate genes for pig fatness traits, there are genes encoding acetyl-CoA carboxylase alpha (ACACA) and sterol regulatory element binding transcription factor 1 (SREBF1). In our study, 5 known and 2 novel SNPs in the ACACA gene and 2 known and 6 novel polymorphisms in the SREBF1 were found. The SNPs segregated as 6 and 10 haplotypes in ACACA and SREBF1, respectively. Two SNPs in ACACA were associated with fatness and performance traits in Polish breeds. In the SREBF1 gene, two novel SNPs were associated with daily gain and one, within a potential intronic micro-RNA gene, showed an association with fatness traits. Breed-specific differences in the transcript level were observed for ACACA only. No correlation between the transcript levels and fatty acid compositions was found in muscle and fat tissues. We concluded that polymorphisms of the ACACA and SREBF1 genes are promising markers for pig carcass and performance traits.
authors: Poznan University of Life Sciences, Department of Genetics and Animal Breeding, Poznan, Poland.
authors: Monika
authors: M
authors: Stachowiak
authors: Joanna
authors: J
authors: Nowacka-Woszuk
authors: Maciej
authors: M
authors: Szydlowski
authors: Marek
authors: M
authors: Switonski
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000235:genetics*; D000273:Adipose Tissue / Q000737:chemistry*; D000818:Animals; D001947:Breeding; D005227:Fatty Acids / Q000737:chemistry*; D005260:Female; D005786:Gene Expression Regulation; D005819:Genetic Markers; D006239:Haplotypes; D008297:Male; D018482:Muscle, Skeletal / Q000737:chemistry*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics*; D013552:Swine
chemical_list: D005227:Fatty Acids; D005819:Genetic Markers; D012333:RNA, Messenger; D051780:Sterol Regulatory Element Binding Protein 1; D000103:Acetyl-CoA Carboxylase