title: Photosensitizer-gold nanorod composite for targeted multimodal therapy.
abstract: In this work, a DNA inter-strand replacement strategy for therapeutic activity is successfully designed for multimodal therapy. In this multimodal therapy, chlorin e6 (Ce6) photosensitizer molecules are used for photodynamic therapy (PDT), while aptamer-AuNRs, are used for selective binding to target cancer cells and for photothermal therapy (PTT) with near infrared laser irradiation. Aptamer Sgc8, which specifically targets leukemia T cells, is conjugated to an AuNR by a thiol-Au covalent bond and then hybridized with a Ce6-labeled photosensitizer/reporter to form a DNA double helix. When target cancer cells are absent, Ce6 is quenched and shows no PDT effect. However, when target cancer cells are present, the aptamer changes structure to release Ce6 to produce singlet oxygen for PDT upon light irradiation. Importantly, by combining photosensitizer and photothermal agents, PTT/PDT dual therapy supplies a more effective therapeutic outcome than either therapeutic modality alone.
authors: Center for Research at the Bio/Nano Interface, Department of Chemistry and Shands Cancer Center, University of Florida Genetics Institute, University of Florida, Gainesville, FL 32611-7200, USA; Ministry of Education Key Laboratory on Luminescence and Real-Time Analysis, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.
authors: Jian
authors: J
authors: Wang
authors: Mingxu
authors: M
authors: You
authors: Guizhi
authors: G
authors: Zhu
authors: Mohammed Ibrahim
authors: MI
authors: Shukoor
authors: Zhuo
authors: Z
authors: Chen
authors: Zilong
authors: Z
authors: Zhao
authors: Meghan B
authors: MB
authors: Altman
authors: Quan
authors: Q
authors: Yuan
authors: Zhi
authors: Z
authors: Zhu
authors: Yan
authors: Y
authors: Chen
authors: Cheng Zhi
authors: CZ
authors: Huang
authors: Weihong
authors: W
authors: Tan
mesh_terms: D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry*; D006801:Humans; D043942:Nanotubes / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D017319:Photosensitizing Agents; D006046:Gold
keywords: aptamer; gold nanorods; multimodal therapy; photosensitizer
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