title: Impact of inherited genetic variants associated with lipid profile, hypertension, and coronary artery disease on the risk of intracranial and abdominal aortic aneurysms.
abstract: BACKGROUND
  Epidemiological studies show that an unfavorable lipid profile and coronary artery disease (CAD) are risk traits for abdominal aortic aneurysms (AAAs) but not for intracranial aneurysms (IAs), and that hypertension is a main risk trait for IAs but not for AAAs. To evaluate these observations, we investigated single-nucleotide polymorphisms associated with serum lipid levels, hypertension, and CAD and tested their contribution to AAA and IA risk.
  
  
  RESULTS
  We defined sets of single-nucleotide polymorphisms previously reported to be associated with serum lipid levels, CAD, and blood pressure. From previously collected genome-wide data, we extracted genotypes for these single-nucleotide polymorphism sets in 709 IA cases and 2692 controls and 807 AAA cases and 1905 controls (all of Dutch origin). We computed genetic scores for each individual by summing the observed number of risk alleles weighted by their previously published effect size. Using logistic regression, we tested the genetic scores for association with IAs and AAAs and found significant associations for genetic scores of total cholesterol (P=3.6×10⁻⁶), low-density lipoprotein-cholesterol (P=5.7×10⁻⁷), and CAD (P=0.0014) with AAAs and for the blood pressure score with IAs (P=0.0030).
  
  
  CONCLUSIONS
  We demonstrate that genetic risk profiles of lipid factors and CAD are associated with AAAs but not with IAs, and the genetic risk profile of blood pressure is associated with IAs but not with AAAs. These findings are consistent with epidemiological observations.
authors: Department of Neurology and Neurosurgery, Utrecht Stroke Center, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands. f.vanthof@umcutrecht.nl
authors: Femke N G
authors: FN
authors: van 't Hof
authors: Ynte M
authors: YM
authors: Ruigrok
authors: Annette F
authors: AF
authors: Baas
authors: Lambertus A L M
authors: LA
authors: Kiemeney
authors: Sita H
authors: SH
authors: Vermeulen
authors: André G
authors: AG
authors: Uitterlinden
authors: Albert
authors: A
authors: Hofman
authors: Fernando
authors: F
authors: Rivadeneira
authors: Gabriël J E
authors: GJ
authors: Rinkel
authors: Paul I W
authors: PI
authors: de Bakker
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D001794:Blood Pressure; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D002532:Intracranial Aneurysm / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D008078:Cholesterol, LDL; D008055:Lipids
keywords: aneurysm; genetics; genetics of cardiovascular disease; risk factors; risk factors for stroke