title: Insights into mitochondrial quality control pathways and Parkinson's disease.
abstract: The brain uses more energy than any other human organ, accounting for 20 % of the body's total demand. Mitochondria are energy-converting organelles with a pivotal role in meeting the energetic needs of the human brain. Therefore, the decline of these cellular powerhouses can have a negative impact on the function and plasticity of neurons and is believed to have a prominent role in ageing and in the occurrence of several neurological disorders, such as Parkinson's disease (PD). As a consequence of their physiological roles, mitochondria are subjected to high levels of stress and have therefore developed several stress-protective mitochondrial quality control mechanisms that ensure the optimal activity of their molecular machinery. Here, we review some of the most recent advances in our understanding of the regulation of mitochondrial stress pathways with particular emphasis on how defective mitochondrial quality control might contribute to PD.
authors: Cell Death Regulation, MRC Toxicology Unit, Lancaster Road, Leicester, LE1 9HN, UK.
authors: Susann
authors: S
authors: Lehmann
authors: L Miguel
authors: LM
authors: Martins
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism*
references: Cell Death Differ. 2009 Mar;16(3):449-64
references: 19023330
references: Science. 2003 Jan 10;299(5604):256-9
references: 12446870
references: PLoS Biol. 2007 Jul;5(7):e172
references: 17579517
references: EMBO J. 2008 Jan 23;27(2):306-14
references: 18216873
references: Hum Mutat. 2008 Jun;29(6):832-40
references: 18401856
references: J Biol Chem. 2003 Dec 5;278(49):49417-27
references: 14512424
references: J Cell Biol. 1996 Nov;135(4):883-93
references: 8922374
references: Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15927-32
references: 15509649
references: Genetics. 2006 Sep;174(1):229-39
references: 16816413
references: Hum Mol Genet. 2008 Jul 1;17(13):1988-93
references: 18364387
references: Nat Rev Mol Cell Biol. 2010 Sep;11(9):621-32
references: 20683470
references: Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5018-23
references: 20194754
references: J Theor Biol. 1993 Dec 21;165(4):609-31
references: 8114509
references: Cell Death Dis. 2013 Jan 17;4:e467
references: 23328674
references: J Biol Chem. 2003 Sep 19;278(38):36373-9
references: 12783892
references: EMBO J. 2008 Jan 23;27(2):433-46
references: 18200046
references: Cell. 2011 Nov 11;147(4):893-906
references: 22078885
references: Hum Mol Genet. 2013 Jul 15;22(14):2829-41
references: 23525905
references: Hum Mol Genet. 2010 Nov 15;19(22):4437-52
references: 20817635
references: Cell. 2011 Mar 4;144(5):689-702
references: 21376232
references: Cell Death Differ. 2009 Jul;16(7):939-46
references: 19229244
references: Hum Mol Genet. 2005 Aug 1;14(15):2099-111
references: 15961413
references: Dev Cell. 2007 Oct;13(4):467-80
references: 17925224
references: Cell Death Differ. 2012 Feb;19(2):257-66
references: 21701498
references: Neurobiol Aging. 2011 Mar;32(3):548.e9-18
references: 20036034
references: Mol Biol Cell. 2001 Aug;12(8):2245-56
references: 11514614
references: Curr Biol. 2012 Mar 20;22(6):545-52
references: 22342752
references: J Cell Sci. 2001 Mar;114(Pt 5):867-74
references: 11181170
references: Mol Cell Biol. 2004 Nov;24(22):9848-62
references: 15509788
references: Mol Cell. 2004 Apr 9;14(1):1-15
references: 15068799
references: Nat Cell Biol. 2010 Feb;12(2):119-31
references: 20098416
references: Nature. 2003 Oct 16;425(6959):721-7
references: 14534547
references: Mol Neurobiol. 2011 Apr;43(2):80-6
references: 21120708
references: Mol Cell. 2010 Feb 26;37(4):529-40
references: 20188671
references: Nat Cell Biol. 2009 Jun;11(6):747-52
references: 19448625
references: PLoS Genet. 2012 Feb;8(2):e1002488
references: 22319455
references: IUBMB Life. 2010 Jan;62(1):14-8
references: 19937972
references: Int J Cell Biol. 2012;2012:607929
references: 22675361
references: Hum Mol Genet. 2012 May 1;21(9):1931-44
references: 22228096
references: Science. 2004 May 21;304(5674):1158-60
references: 15087508
references: Curr Biol. 2012 Jan 24;22(2):135-41
references: 22226745
references: Cell. 1997 Jul 11;90(1):121-9
references: 9230308
references: Science. 2012 Aug 3;337(6094):587-90
references: 22700657
references: J Neurochem. 2012 Aug;122(3):650-8
references: 22639965
references: Am J Pathol. 2013 Feb;182(2):474-84
references: 23231918
references: Expert Rev Mol Med. 2010 Apr 19;12:e12
references: 20398440
references: Neuroscientist. 2006 Aug;12(4):291-9
references: 16840705
references: Cell Death Differ. 2012 Aug;19(8):1308-16
references: 22301916
references: Nat Cell Biol. 2007 Nov;9(11):1243-52
references: 17906618
references: Science. 2012 Jun 8;336(6086):1306-10
references: 22582012