title: Translational utility of next-generation sequencing.
abstract: The development of next-generation sequencing (NGS) technology has made DNA sequencing not only rapid and cost-effective, but also highly accurate and reproducible. The translational utility of genomic sequencing is clear, from understanding of human genetic variation and its association with disease risk and individual response to treatment, to the interpretation and translation of the data for clinical decision making. It will be a critical technology for disease characterization and monitoring in molecular pathology and is expected to become a central piece of routine healthcare management which will result in accurate and reliable reporting, a prerequisite for physicians to practice genomic medicine.
authors: Illumina, Inc., San Diego, CA 92122, USA.
authors: Frank S
authors: FS
authors: Ong
authors: Jimmy C
authors: JC
authors: Lin
authors: Kingshuk
authors: K
authors: Das
authors: Daniel S
authors: DS
authors: Grosu
authors: Jian-Bing
authors: JB
authors: Fan
mesh_terms: D002869:Chromosome Aberrations; D020869:Gene Expression Profiling; D005826:Genetics, Medical / Q000379:methods; D015894:Genome, Human; D023281:Genomics; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods; D017422:Sequence Analysis, DNA; D017423:Sequence Analysis, RNA; D057170:Translational Research, Biomedical
keywords: Cancer genome sequencing; Clinical sequencing; NGS; NIPT; Next-generation sequencing; Non-invasive diagnosis