title: Host and viral factors affecting clinical performance of a rapid diagnostic test for respiratory syncytial virus in hospitalized children.
abstract: Respiratory syncytial virus rapid antigen detection tests (RADT) are used widely. RADT exhibited high specificity (97%) and moderate sensitivity (80%) compared with reverse-transcriptase polymerase chain reaction in 720 hospitalized children <3 years old. Older age, prolonged symptoms, and respiratory syncytial virus genotype-B infection were significantly associated with false-negative results of RADT.
authors: Department of Epidemiology, McGill University, Montreal, Quebec, Canada. jesse.papenburg@mail.mcgill.ca
authors: Jesse
authors: J
authors: Papenburg
authors: David L
authors: DL
authors: Buckeridge
authors: Gaston
authors: G
authors: De Serres
authors: Guy
authors: G
authors: Boivin
mesh_terms: D000956:Antigens, Viral / Q000032:analysis*; D002675:Child, Preschool; D002846:Chromatography, Affinity; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018357:Respiratory Syncytial Virus Infections / Q000175:diagnosis* / Q000821:virology; D018113:Respiratory Syncytial Virus, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012680:Sensitivity and Specificity
chemical_list: D000956:Antigens, Viral; D004279:DNA, Viral
keywords: RADT; RSV; RT-PCR; RTI; Rapid antigen detection test; Respiratory syncytial virus; Respiratory tract infection; Reverse-transcriptase polymerase chain reaction