title: [Clinical analysis of hypoparathyroidism with altered serum muscle enzymes: report of 41 cases].
abstract: OBJECTIVE
  To examine the clinical features of hypoparathyroidism (HP) with altered serum muscle enzymes and explore the correlations with age, gender, disease duration, serum total calcium, serum total phosphorus and parathyroid hormone (PTH).
  
  
  METHODS
  From January 2005 to October 2011, a total of 41 HP patients at our hospital were retrospectively analyzed.
  
  
  RESULTS
  There were 16 patients with elevated serum muscle enzymes and 25 with normal serum muscle enzymes. The former group included 11 patients of idiopathic hypoparathyroidism (IHP) and 5 of pseudohypoparathyroidism (PHP); serum calcium was (1.53 ± 0.25) mmol/L and serum phosphorus (2.1 ± 0.6) mmol/L; medians of creatine kinase (CK), lactic dehydrogenase (LDH), aspartate amino transfer enzymes (AST) were 309 (126 - 10 046), 279 (131 - 741) and 27 (17 - 467) U/L in HP patients respectively. And the latter group included 20 IHP patients and 5 PHP ones; serum calcium was (1.64 ± 0.29) mmol/L and serum phosphorus (2.2 ± 0.6) mmol/L. The levels of serum muscle enzyme were compared before and after treatment in the former group. And they significantly declined with the rising serum level of calcium after treatment. The serum levels of CK (r = -0.82), LDH (r = -0.55) and AST (r = -0.56) in HP patients with elevated serum muscle enzymes had a negative correlation with the serum level of calcium (all P < 0.05). And there was no correlation with age, gender, disease duration or serum total phosphorus (P > 0.05).
  
  
  CONCLUSIONS
  Elevated serum muscle enzymes in HP patients have a negative correlation with serum level of calcium and there is no correlation with age, gender, disease duration, serum total phosphorus or parathyroid hormone. And elevated serum muscle enzymes are gradually restored with the normalized serum level of calcium.
authors: Department of Endocrinology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. wuwenxun@126.com
authors: Wen-xun
authors: WX
authors: Wu
authors: Xiao-yan
authors: XY
authors: Ren
authors: Chen-guang
authors: CG
authors: Zhai
mesh_terms: D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000097:blood*; D007223:Infant; D045022:Lactate Dehydrogenases / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D010281:Parathyroid Hormone; D010758:Phosphorus; D045022:Lactate Dehydrogenases; D003402:Creatine Kinase; D002118:Calcium