title: In vivo diffuse correlation spectroscopy investigation of the ocular fundus.
abstract: Diffuse correlation spectroscopy (DCS) measurements in vivo recorded from rabbits' ocular fundus are presented. Despite the complexity of these ocular tissues, we provide a clear and simple demonstration of the DCS abilities to analyze variations in physiological quantities of clinical interest. Indeed, the reported experimental activities demonstrate that DCS can reveal both choroidal-flow and temperature variations and detect nano- and micro-aggregates in ocular fundus circulation. Such abilities can be of great interest both in fundamental research and practical clinical applications. The proposed measuring system can be useful in: (a) monitoring choroidal blood flow variations, (b) determining the end-point for photo-dynamic therapy and transpupillary thermo therapy and, (c) managing the dye injection and determining an end-point for dye-enhanced photothrombosis. Moreover, it could allow both diagnoses when the presence of nano- and micro-aggregates is related to specific diseases and verifying the effects of nanoparticle injection in nanomedicine. Even though the reported results demonstrate the applicability of DCS to investigate ocular fundus, a detailed and accurate investigation of the limits of detection is beyond the scope of this article.
authors: University of Modena and Reggio Emilia, Department of Engineering Enzo Ferrari, Via Vignolese 905, 41125 Modena, Italy. stefano.cattini@unimore.it
authors: Stefano
authors: S
authors: Cattini
authors: Giovanni
authors: G
authors: Staurenghi
authors: Antonietta
authors: A
authors: Gatti
authors: Luigi
authors: L
authors: Rovati
mesh_terms: D000818:Animals; D002829:Choroid / Q000098:blood supply*; D003941:Diagnostic Techniques, Ophthalmological; D005654:Fundus Oculi; D006046:Gold / Q000737:chemistry; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry; D011817:Rabbits; D012039:Regional Blood Flow / Q000502:physiology; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods*; D013696:Temperature
chemical_list: D006046:Gold