title: "The Infinite Maze" of breast cancer, signaling pathways and radioresistance.
abstract: The parallel growth in our understanding of tumor biology and genetics might be the key to understanding local recurrence after optimal treatment is applied. Data suggest that genetic alterations and breast cancer molecular subtypes have an effect on radiotherapy efficacy and that the HER2, EGFR/PI3K/Akt signaling pathways play a pivotal role in modulation of post-irradiation survival. These pathways have been found to be involved in radiosensitivity and/or radioresistance, tumor cell proliferation, and hypoxia. Therefore, affecting the functional activity of key players combined with radiotherapy might be the future of breast irradiation.
authors: Division of Oncology, Rambam Health Care Campus, and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors: Orit
authors: O
authors: Kaidar-Person
authors: Christine
authors: C
authors: Lai
authors: Abraham
authors: A
authors: Kuten
authors: Yazid
authors: Y
authors: Belkacemi
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000532:radiotherapy*; D049109:Cell Proliferation; D005260:Female; D018773:Genes, erbB-1; D018734:Genes, erbB-2; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics*; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics*; D011836:Radiation Tolerance / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt