title: Evaluation of hepatoprotective activity of water-soluble polysaccharide fraction of Stellaria media L.
abstract: Therapy of rats with CCl4 hepatitis with Stellaria media L. water-soluble polysaccharide fraction in a dose of 100 mg/kg reduces serum activities of transaminases (ALT and AST), alkaline phosphatase, bilirubin, and the thymol test values. In the liver, the density of inflammatory infiltration of the organ parenchyma, total count of necrotic hepatocytes, fatty and protein degeneration are reducing. Hence, water-soluble polysaccharide fraction, isolated from the terrestrial part of Stellaria media L., is characterized by hepatoprotective activity.
authors: Siberian State Medical University, the Russian Ministry of Health, Russia.
authors: Ya V
authors: YV
authors: Gorina
authors: E V
authors: EV
authors: Saprykina
authors: E A
authors: EA
authors: Gereng
authors: T V
authors: TV
authors: Perevozchikova
authors: E A
authors: EA
authors: Krasnov
authors: E V
authors: EV
authors: Ivanova
authors: E A
authors: EA
authors: Fait
authors: O V
authors: OV
authors: Baranova
mesh_terms: D000410:Alanine Transaminase / Q000097:blood / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D001663:Bilirubin / Q000097:blood / Q000378:metabolism; D002251:Carbon Tetrachloride; D006505:Hepatitis / Q000188:drug therapy*; D022781:Hepatocytes / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D011134:Polysaccharides / Q000627:therapeutic use; D051381:Rats; D012995:Solubility; D029752:Stellaria / Q000737:chemistry*; D013944:Thymolphthalein / Q000031:analogs & derivatives
chemical_list: D028321:Plant Preparations; D011134:Polysaccharides; C013713:thymol blue; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin; D013944:Thymolphthalein