title: A case of pancreatic ductal adenocarcinoma with marked infiltration with IgG4-positive cells.
abstract: A 75-year-old man was diagnosed as having pancreatic ductal carcinoma containing remarkable lymphocytic and plasma cell infiltration, as revealed by the cytological examination of endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) specimen. The EUS-FNA specimen showed small amounts of atypical epithelium with noticeable lymphocytes and plasma cells. A pancreatic resection was performed, and the histopathological features showed an invasive pancreatic ductal carcinoma with autoimmune pancreatitis (AIP) lymphoplasmacytic sclerosing pancreatitis (LPSP)-like lesions. Most of the plasma cells were immunoreactive to anti-IgG4 antibody. EUS-FNA may be necessary for the differential diagnosis of AIP and pancreatic cancer, and close attention should be given to the presence of marked lymphoplasmacytic cells in EUS-FNA specimens while making the diagnosis.
authors: Department of Pathologic Oncology, Institute of Molecular and Experimental Medicine, Faculty of Medicine, Mie University Graduate School of Medicine, Japan.
authors: M
authors: M
authors: Yoneda
authors: H
authors: H
authors: Inada
authors: K
authors: K
authors: Kanayama
authors: T
authors: T
authors: Shiraishi
keywords: Adenocarcinoma; IgG4; autoimmune pancreatitis; endoscopic ultrasound guided fine-needle aspiration
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