title: A rational approach towards a new ferrocenyl pyrrolidine for stereoselective enamine catalysis.
abstract: Ironing out the details: Proline and pyrrolidine derivatives (Hayashi- Jørgensen catalysts) are considered "work horses" in organocatalysis. This report describes a new effective ferrocenyl pyrrolidine catalyst that is able to perform well in benchmark organocatalytic reactions (see figure). The ferrocene moiety controls the conformational space and a simple alkyl group effectively covers a face of the derived enamine. This new framework can find applications in organocatalysis, and in general, in new ligand design.
authors: ALMA MATER STUDIORUM, Dipartimento di Chimica G. Ciamician, Via Selmi 2, 40126 Bologna, Italy.
authors: Diego
authors: D
authors: Petruzziello
authors: Marco
authors: M
authors: Stenta
authors: Andrea
authors: A
authors: Mazzanti
authors: Pier Giorgio
authors: PG
authors: Cozzi
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D005296:Ferrous Compounds; D011759:Pyrrolidines; D011392:Proline