title: Cationic porphyrin-quinoxaline conjugate as a photochemically triggered novel cytotoxic agent.
abstract: A novel cationic porphyrin-quinoxaline conjugate 8 was prepared in good yield by the coupling of activated quinoxaline carboxylic acid 5 with an appropriate aminoporphyrin. The UV-vis spectra of conjugate 8 with the addition of ctDNA shows substantial hypochromicity (39%) and a red shift (12 nm) in the Soret band indicating intercalation and self stacking along the surface. The binding constant of conjugate 8 with ctDNA was determined to be 1.26×10(6) M(-1). The porphyrin-quinoxaline conjugate 8 displayed enhanced photocytotoxicity (IC50=0.06 μM) when compared to TMPyP against A549 cancer cells.
authors: Department of Chemistry, Birla Institute of Technology and Science, Pilani 333031, India. dalipk@pilani.bits-pilani.ac.in.com
authors: Dalip
authors: D
authors: Kumar
authors: K P
authors: KP
authors: Chandra Shekar
authors: Bhupendra
authors: B
authors: Mishra
authors: Ryohsuke
authors: R
authors: Kurihara
authors: Maiko
authors: M
authors: Ogura
authors: Takeo
authors: T
authors: Ito
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D002412:Cations / Q000737:chemistry; D002417:Cattle; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D053837:DNA Cleavage / Q000187:drug effects; D006801:Humans; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D011810:Quinoxalines / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D013050:Spectrometry, Fluorescence; D014466:Ultraviolet Rays
chemical_list: D000970:Antineoplastic Agents; D002412:Cations; D011166:Porphyrins; D011810:Quinoxalines; D004247:DNA; C427203:calf thymus DNA