title: The influence of steroid administration on systemic response in laminoplasty for cervical myelopathy.
abstract: BACKGROUND
  The excessive systemic inflammatory response caused by surgery has been associated with the development of major complications, such as postoperative confusion and acute respiratory distress syndrome. The serum IL-6 has been used as a predictor in the extent of surgical trauma. Several trials have reported that steroid administration reduced excessive systemic response. We investigated the systemic response caused by surgical trauma in patients with cervical laminoplasty and evaluated the influence of steroid administration on systemic response.
  
  
  METHODS
  Thirty patients were included in this study. The patients were divided into three groups of ten each: preoperative steroid group, intraoperative steroid group, and non-steroid group. The same dose of steroid was administered to the patients in preoperative group and intraoperative group. Venous blood samples were taken at the following times: before surgery, at the end of surgery, 6 h after the surgery, the first, the third and the seventh day after the surgery. Outcome measures were serum IL-6, IL-10, C-reactive protein (CRP), white blood cells including neutrophil and lymphocyte counts.
  
  
  RESULTS
  The mean serum IL-6 levels on the first day in preoperative and intraoperative steroid groups were significantly lower than in control group. The serum IL-6 levels in preoperative steroid group were lower than the serum levels in the intraoperative steroid group from the end of surgery to the third day after surgery. The CRP levels in steroids groups were also lower than in control group on the third day. There were no significant differences in the postoperative neutrophil count between the three groups. There was no postoperative infectious complication or suture failure.
  
  
  CONCLUSIONS
  This study shows that the preoperative administration of steroids modified the systemic inflammatory response caused by surgical trauma in patients with cervical laminoplasty.
authors: Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan. msdemura@gmail.com
authors: Satoru
authors: S
authors: Demura
authors: Keisuke
authors: K
authors: Takahashi
authors: Hideki
authors: H
authors: Murakami
authors: Yoshiyasu
authors: Y
authors: Fujimaki
authors: Satoshi
authors: S
authors: Kato
authors: Hiroyuki
authors: H
authors: Tsuchiya
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis*; D002574:Cervical Vertebrae / Q000601:surgery*; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures; D011184:Postoperative Period; D013118:Spinal Cord Diseases / Q000601:surgery*; D013312:Stress, Physiological / Q000187:drug effects*
chemical_list: D005938:Glucocorticoids; D015850:Interleukin-6; D003907:Dexamethasone; D002097:C-Reactive Protein