title: The dopamine receptor D1 gene is associated with the length of interval between first heroin use and onset of dependence in Chinese Han heroin addicts.
abstract: Previous researches showed that the dopamine receptor D1 (DRD1) may play a critical role in drug dependence. This research aimed to determine whether DRD1 played a role in development of heroin dependence in Chinese heroin-dependent patients. 465 Chinese Han heroin-dependent subjects and 379 healthy controls were recruited in the Shanghai region. Five single-nucleotide-polymorphisms (SNPs) of the DRD1 gene were genotyped in all subjects. The results found that the frequencies of DRD1 SNP genotypes or haplotypes were not different between heroin-dependent patients and controls. Among heroin-dependent patients, subjects with rs5326CC and/or rs6882300AA genotypes develop to heroin-dependent more rapidly than those without rs5326CC and/or rs6882300AA genotypes. The results indicated that DRD1 gene polymorphism may not play an important role in the susceptibility of heroin dependence in the Chinese Han population, but it may be associated with the rapidity of heroin dependence development from first drug use.
authors: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, 200030, China.
authors: Sufang
authors: S
authors: Peng
authors: Jiang
authors: J
authors: Du
authors: Haifeng
authors: H
authors: Jiang
authors: Yingmei
authors: Y
authors: Fu
authors: Hanhui
authors: H
authors: Chen
authors: Haiming
authors: H
authors: Sun
authors: Dongxiang
authors: D
authors: Wang
authors: Shunying
authors: S
authors: Yu
authors: Min
authors: M
authors: Zhao
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D055030:Drug Users; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006556:Heroin Dependence / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D013997:Time Factors
chemical_list: D017447:Receptors, Dopamine D1
references: Drug Alcohol Depend. 2009 Jan 1;99(1-3):68-78
references: 18768267
references: Brain Res Brain Res Rev. 1991 Sep-Dec;16(3):223-44
references: 1665095
references: Biochem Biophys Res Commun. 2007 Jun 15;357(4):1135-41
references: 17466946
references: Pharmacogenet Genomics. 2012 Jul;22(7):551-4
references: 22495174
references: Mol Psychiatry. 2013 Nov;18(11):1205-10
references: 23044706
references: Alcohol Clin Exp Res. 2008 Apr;32(4):567-72
references: 18341651
references: Behav Pharmacol. 2009 Feb;20(1):1-17
references: 19179847
references: Nat Rev Genet. 2009 Apr;10(4):225-31
references: 19238175
references: Alcohol Clin Exp Res. 2003 Aug;27(8):1226-8
references: 12966314
references: Brain Res. 2011 Oct 28;1420:106-13
references: 21955727
references: Psychopharmacology (Berl). 1994 Apr;114(3):486-94
references: 7855207
references: Pharmacol Rev. 2002 Mar;54(1):1-42
references: 11870259
references: Addiction. 2009 Sep;104(9):1512-8
references: 19686520
references: Psychopharmacology (Berl). 2004 Dec;177(1-2):100-10
references: 15338099
references: Hum Genet. 2008 Mar;123(2):133-40
references: 18092181
references: Nature. 1995 Aug 17;376(6541):572-5
references: 7637804
references: Psychiatry Clin Neurosci. 2006 Apr;60(2):226-31
references: 16594948
references: Neuroscience. 2006;137(2):699-706
references: 16289883
references: Cell Res. 2005 Feb;15(2):97-8
references: 15740637
references: Psychopharmacology (Berl). 2009 Sep;206(1):51-60
references: 19506837
references: Behav Genet. 2006 Jan;36(1):100-11
references: 16374522
references: Nat Neurosci. 2005 Nov;8(11):1450-7
references: 16251987
references: Arch Gen Psychiatry. 1999 Jul;56(7):655-61
references: 10401514
references: Am J Med Genet. 1996 Sep 20;67(5):473-7
references: 8886164
references: Behav Brain Res. 2011 Oct 1;223(2):329-35
references: 21596067
references: J Neurosci. 2007 Nov 14;27(46):12655-63
references: 18003845
references: Genes Brain Behav. 2009 Jul;8(5):531-40
references: 19500151
references: Hum Genet. 2012 Jun;131(6):803-22
references: 22350797
references: Mol Psychiatry. 1997 Jan;2(1):44-56
references: 9154217
references: J Pharmacol Exp Ther. 2007 Jun;321(3):1135-43
references: 17351103
references: Neurosci Biobehav Rev. 1989 Summer-Fall;13(2-3):123-8
references: 2530477
references: Subst Use Misuse. 2008;43(3-4):317-30
references: 18365934
references: Psychiatr Genet. 2007 Dec;17(6):323-32
references: 18075472
references: Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2117-22
references: 15684065