title: The short-term effects of soybean intake on oxidative and carbonyl stress in men and women.
abstract: Beyond other beneficial effects, a soy-rich diet has been shown to reduce the risk of cardiovascular diseases and diabetic complications. Reduction of oxidative and carbonyl stress has been proposed as the underlying mechanism, but the evidence for this is lacking. The aim of our study was to evaluate the effects of short-term increased soy intake on oxidative and carbonyl stress parameters in young volunteers. Young healthy probands (omnivores) of both genders (55 women, 33 men) were given soybeans (2 g/kg bodyweight daily) for one week. Markers of oxidative and carbonyl stress were measured in plasma at the beginning and at the end of one week soybean intake and after another week of a wash-out period. Total antioxidant capacity was increased by soybean intake in both genders. This led to decreased levels of advanced oxidation protein products in women, but not in men. On the contrary, in men, soybean intake increased lipoperoxidation. No effects on carbonyl stress markers (advanced glycation end products-specific fluorescence and fructosamine) were found. Soybean intake has gender-specific effects on oxidative stress in young healthy probands potentially due to divergent action and metabolism of phytoestrogens in men and women. Effects of soybean intake on carbonyl stress should be evaluated in longer studies.
authors: Institute of Molecular Biomedicine, Comenius University, Bratislava 81108, Slovakia. petercelec@gmail.com
authors: Peter
authors: P
authors: Celec
authors: Július
authors: J
authors: Hodosy
authors: Roland
authors: R
authors: Pálffy
authors: Roman
authors: R
authors: Gardlík
authors: Lukáč
authors: L
authors: Halčák
authors: Daniela
authors: D
authors: Ostatníková
mesh_terms: D000293:Adolescent; D000328:Adult; D062107:Advanced Oxidation Protein Products / Q000097:blood*; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D018384:Oxidative Stress; D012727:Sex Characteristics; D013025:Glycine max
chemical_list: D062107:Advanced Oxidation Protein Products; D000975:Antioxidants; D015415:Biomarkers; D017127:Glycation End Products, Advanced
references: JAMA. 2009 Dec 9;302(22):2437-43
references: 19996398
references: J Steroid Biochem Mol Biol. 2006 Nov;101(4-5):246-53
references: 16965913
references: Kidney Int. 2003 Jul;64(1):82-91
references: 12787398
references: Eur J Nutr. 1999 Jun;38(3):143-8
references: 10443336
references: Fertil Steril. 2007 Dec;88(6):1632-6
references: 17517399
references: Semin Reprod Endocrinol. 1998;16(4):309-14
references: 10101811
references: J Lipid Res. 1998 Nov;39(11):2111-8
references: 9799796
references: Eur J Clin Nutr. 2003 Aug;57(8):889-94
references: 12879082
references: Obstet Gynecol. 2002 Mar;99(3):389-94
references: 11864664
references: Am J Clin Nutr. 1998 Nov;68(5):1081-7
references: 9808226
references: J Nutr. 2009 Jun;139(6):1128-34
references: 19339704
references: Nutr Cancer. 2009;61(5):598-606
references: 19838933
references: Menopause. 2005 May-Jun;12(3):299-307
references: 15879919
references: Nutr Res. 2009 Sep;29(9):616-22
references: 19854376
references: Am J Clin Nutr. 2005 Mar;81(3):590-6
references: 15755827
references: Cancer Lett. 2001 Oct 22;172(1):1-6
references: 11595123
references: Carcinogenesis. 2002 Sep;23(9):1491-6
references: 12189192
references: Nutr Metab Cardiovasc Dis. 2009 Feb;19(2):91-7
references: 18571392
references: Endocr Regul. 2008 Jun;42(2-3):53-61
references: 18624607
references: Am J Clin Nutr. 2009 Apr;89(4):1155-63
references: 19211820
references: Biochem Pharmacol. 2000 Jul 1;60(1):1-5
references: 10807939
references: Am J Clin Nutr. 2008 Jan;87(1):162-7
references: 18175751
references: FASEB J. 2005 Oct;19(12):1755-7
references: 16107535
references: Lipids. 2006 Mar;41(3):257-65
references: 16711600
references: J Nutr. 2002 Jul;132(7):1900-2
references: 12097666
references: Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2524-31
references: 9409223
references: Nutr Cancer. 2005;53(1):73-81
references: 16351509
references: Eur J Clin Nutr. 2003 Aug;57(8):940-6
references: 12879088
references: Metabolism. 2005 Sep;54(9):1181-8
references: 16125530
references: Expert Opin Investig Drugs. 2000 Aug;9(8):1829-40
references: 11060780
references: Menopause. 2001 Sep-Oct;8(5):384-92
references: 11528367
references: Maturitas. 2002 Aug 30;42(4):295-300
references: 12191852
references: J Nutr Biochem. 2007 Jan;18(1):46-53
references: 16626957
references: J Obstet Gynaecol Res. 2009 Dec;35(6):1083-90
references: 20025635
references: Food Chem Toxicol. 2009 Mar;47(3):625-32
references: 19146912
references: Am J Clin Nutr. 2004 Sep;80(3):692-9
references: 15321810
references: J Nutr. 1998 Feb;128(2):209-13
references: 9446845
references: Carcinogenesis. 2000 Jun;21(6):1247-52
references: 10837017
references: Free Radic Biol Med. 2009 Jul 15;47(2):167-75
references: 19393315
references: J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Sep 25;777(1-2):211-8
references: 12270214
references: Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1050-9
references: 19318430