title: Secondary metabolites from the stem of Ravenia spectabilis Lindl.
abstract: BACKGROUND
  Ravenia spectabilis is a medium tall shrub found widespread in South America. It also found in India, Pakistan, Bangladesh etc. Few alkaloid and steroid compounds were reported from the plant previously.
  
  
  METHODS
  Methanol extract from the stems of Ravenia spectabilis were partitioned into n-hexane, carbon tetrachloride, chloroform and aqueous soluble fractions, respectively. The crude methanol extract, carbon tetrachloride fraction and chloroform fraction were fractionated by column chromatography of Silica gel and Sephadex LH-20 for isolation and purification of compounds. The structures of the isolated compounds were determined by extensive NMR spectral analysis, including 2D NMR, mass spectroscopy etc.
  
  
  RESULTS
  Ten compounds, γ-fagarine (1), ravenoline (2), N-methyl atanine (3),2,3,3,5-tetramethyl-2,3,4,5- tetrahydrofurano [3,2-c] quinolin-4-one (4), arborinine (5), 3-geranyl indole (6), atanine (7), steroids sitosta-4-en- 3-one (8), stigmasterol (9) and 3-methoxy-4-hydroxy cinnamic acid (10) were isolated from the stems of Ravenia spectabilis.
  
  
  CONCLUSIONS
  Compounds N-methyl atanine (3), 2,3,3,5-tetramethyl-2,3,4,5-tetrahydrofurano [3,2-c] quinolin-4-one (4), 3-geranyl indole (6), sitosta-4-en-3-one (8) and 3-methoxy-4-hydroxy cinnamic acid (10) were isolated from this plant for the first time. 3-geranyl indole (6) was also isolated second time from natural sources.
authors: Organic Research Laboratory, Department of Chemistry, Faculty of Science, Jagannath University, Dhaka-1100, Bangladesh.
authors: Md Mozammel
authors: MM
authors: Haque
authors: Sufia
authors: S
authors: Begum
authors: Md Hossain
authors: MH
authors: Sohrab
authors: Monira
authors: M
authors: Ahsan
authors: Choudhury M
authors: CM
authors: Hasan
authors: Nuruddin
authors: N
authors: Ahmed
authors: Rashedul
authors: R
authors: Haque
keywords: 3-methoxy-4-hydroxy cinnamic acid; Ravenia spectabilis; alkaloids; rutaceae; steroids
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