title: Pentatricopeptide repeats: modular blocks for building RNA-binding proteins.
abstract: Pentatricopeptide repeat (PPR) proteins control diverse aspects of RNA metabolism across the eukaryotic domain. Recent computational and structural studies have provided new insights into how they recognize RNA, and show that the recognition is sequence-specific and modular. The modular code for RNA-binding by PPR proteins holds great promise for the engineering of new tools to target RNA and identifying RNAs bound by natural PPR proteins.
authors: Western Australian Institute for Medical Research and Centre for Medical Research; The University of Western Australia; Perth, WA Australia; School of Chemistry and Biochemistry; The University of Western Australia; Crawley, WA Australia.
authors: Aleksandra
authors: A
authors: Filipovska
authors: Western Australian Institute for Medical Research and Centre for Medical Research; The University of Western Australia; Perth, WA Australia; School of Chemistry and Biochemistry; The University of Western Australia; Crawley, WA Australia.
authors: Oliver
authors: O
authors: Rackham
mesh_terms: D020816:Amino Acid Motifs; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000378:metabolism; D015202:Protein Engineering / Q000379:methods; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D043262:Ribonuclease P / Q000737:chemistry / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D016601:RNA-Binding Proteins; D012321:DNA-Directed RNA Polymerases; C519567:POLRMT protein, human; C581753:PRORP1 protein, Arabidopsis; D043262:Ribonuclease P
keywords: RNA-binding; RNA-protein interactions; pentatricopeptide repeat; repeat proteins; synthetic biology
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