title: A secular increase in BMD in Chinese women.
abstract: Population-based studies have revealed a decline in the incidence of age-adjusted hip fractures in southern Chinese women during the past decade. To determine whether there was a secular change in population characteristics that accounted for this decline, we compared the bone mineral density (BMD) and lifestyle habits of two cohorts of women who were more than 50 years of age and who were recruited from 1995 to 2000 and 2005 to 2010. The BMD levels in the 2005-2010 cohort were significantly higher at the spine and hip and ranged from 3.6 to 17.8% among the different age groups. Additionally, a significantly lower prevalence of subjects with osteoporosis and osteopenia was observed. Longer reproductive years, higher levels of physical activity, higher estradiol and 25(OH) vitamin D levels, and lower alkaline phosphatase levels were found in the 2005-2010 cohort. After adjusting for bone-determining factors, significant differences were detected in the BMD levels at the lumbar spine, femoral neck, and total hip (4.17, 9.02, and 9.34%, respectively) in women >50 years of age but not in women ≤50 years of age. The secular increase in BMD and healthier lifestyles most likely led to the decline in the incidence of age-adjusted fractures.
authors: Department of Medicine, The University of Hong Kong and Queen Mary Hospital, Hospital Authority, Hong Kong, China.
authors: Elaine
authors: E
authors: Cheung
authors: Cora
authors: C
authors: Bow
authors: Connie
authors: C
authors: Loong
authors: K K
authors: KK
authors: Lee
authors: A Y Y
authors: AY
authors: Ho
authors: Cissy
authors: C
authors: Soong
authors: Y Y
authors: YY
authors: Chan
authors: Kathyn C B
authors: KC
authors: Tan
authors: Annie W C
authors: AW
authors: Kung
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015519:Bone Density / Q000502:physiology*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology / Q000503:physiopathology; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
references: Osteoporos Int. 2011 Oct;22(10):2645-54
references: 21210082
references: Osteoporos Int. 2012 Feb;23(2):771-80
references: 21625885
references: Osteoporos Int. 2009 Nov;20(11):1939-45
references: 19326036
references: JAMA. 2009 Oct 14;302(14):1573-9
references: 19826027
references: J Bone Miner Res. 2007 Jul;22(7):1080-7
references: 17371165
references: Curr Med Res Opin. 2008 Jan;24(1):99-106
references: 18028585
references: Osteoporos Int. 2007 May;18(5):585-91
references: 17146592
references: Osteoporos Int. 2010 Mar;21(3):399-408
references: 19484169
references: J Bone Miner Metab. 2005;23(6):470-5
references: 16261454
references: Osteoporos Int. 2011 Feb;22(2):667-74
references: 20503038
references: J Psychosom Obstet Gynaecol. 1997 Jun;18(2):65-72
references: 9219101
references: Clin Orthop Relat Res. 1996 Feb;(323):65-74
references: 8625608
references: Osteoporos Int. 2009 May;20(5):687-94
references: 18797813
references: Breast Cancer Res. 2012 May 14;14(3):R76
references: 22583394
references: Ann Nutr Metab. 2007;51(1):59-64
references: 17356256
references: J Bone Miner Res. 2000 Oct;15(10):2019-25
references: 11028456
references: Osteoporos Int. 1999;10(6):456-61
references: 10663345
references: J Bone Miner Res. 2010 Jan;25(1):64-71
references: 19580459
references: J Bone Miner Metab. 2011 Nov;29(6):725-35
references: 21594583