title: Genome-wide scan on total serum IgE levels identifies no common variants in a healthy Chinese male population.
abstract: Immunoglobulin E (IgE) provides important information on the humoral immune status, and the IgE level is routinely detected in clinical practice. There are many diseases associated with IgE, such as atopic disease, autoimmune diseases, and so on. IgE is a genetically complex trait, but comprehensive genetic assessment of the variability in serum IgE levels is lacking. Previous genome-wide association studies (GWAS) on total serum IgE levels have identified FCER1A as the susceptibility locus; however, the candidate gene association study in southern Chinese patients reported no association. Given the genetic difference in different populations, we firstly conducted this two-stage GWAS in a Chinese population of 3,495 men, including 1,999 unrelated subjects in the first stage and 1,496 independent individuals replicated in the second stage. In the first stage, we totally identified three single nucleotide polymorphisms (SNPs) which reached a P value of 1.0 × 10⁻⁵. Rs17090302 on chromosome 3 and Rs28708846 on chromosome 13 are intergenic. Rs432085 from chromosome 3p28 is located in the gene CCDC50. When the two-stage data was combined, none of the SNPs reached the genome-wide significant level. Collectively, we did not identify novel loci associated with the serum IgE level in Chinese males, but we hypothesized that CCDC50 was a candidate gene in regulation on IgE level.
authors: Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, No. 22 Shuangyong Road, 530021, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China.
authors: Ming
authors: M
authors: Liao
authors: Dianchun
authors: D
authors: Shi
authors: Yao
authors: Y
authors: Wang
authors: Kai
authors: K
authors: Zhang
authors: Xin
authors: X
authors: Chen
authors: Yong
authors: Y
authors: Gao
authors: Aihua
authors: A
authors: Tan
authors: Qiang
authors: Q
authors: Xuan
authors: Xiaobo
authors: X
authors: Yang
authors: Yanlin
authors: Y
authors: Hu
authors: Xue
authors: X
authors: Qin
authors: Haiying
authors: H
authors: Zhang
authors: Zengnan
authors: Z
authors: Mo
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D056426:Genetic Loci; D005828:Genetics, Population / Q000379:methods; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood* / Q000235:genetics; D047908:Intracellular Signaling Peptides and Proteins / Q000032:analysis / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014158:Transcription, Genetic
chemical_list: C478972:CCDC50 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D007073:Immunoglobulin E
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