title: Potential and problems in ultrasound-responsive drug delivery systems.
abstract: Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS) have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles. Drugs that can be loaded into URDDS include small molecules, biomacromolecules, and inorganic substances. Fields of clinical application include anticancer therapy, treatment of ischemic myocardium, induction of an immune response, cartilage tissue engineering, transdermal drug delivery, treatment of Huntington's disease, thrombolysis, and disruption of the blood-brain barrier. This review focuses on recent advances in URDDS, and discusses their formulations, clinical application, and problems, as well as a perspective on their potential use in the future.
authors: Wenzhou Medical College, Wenzhou City, Zhejiang Province, People's Republic of China.
authors: Ying-Zheng
authors: YZ
authors: Zhao
authors: Li-Na
authors: LN
authors: Du
authors: Cui-Tao
authors: CT
authors: Lu
authors: Yi-Guang
authors: YG
authors: Jin
authors: Shu-Ping
authors: SP
authors: Ge
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D050997:Nanomedicine / Q000379:methods; D013010:Sonication / Q000379:methods; D014465:Ultrasonics / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods
keywords: clinical application; targeted therapy; ultrasound
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