title: CD47 is expressed abnormally on hematopoietic cells in myelodysplastic syndrome.
abstract: The increased LSC in MDS has correlation with the progression to AML, which the mechanism of immune evasion is unclear. Our study showed the expression of CD47 on LSC of the patients in high-risk MDS based on IPSS/WPSS score was higher than that of in low-risk MDS and controls. The level of CD47 on erythroblast of MDS patients had a significant positive correlation with their peripheral RBC count. It suggested that the proportion of CD34(+)CD38(-)CD47(+) cells increased in high-risk MDS which might protect LSC from avoiding phagocytosis, and low-expression of CD47 on erythroblast in MDS might be correlated to anemia.
authors: Hematology Department, General Hospital, Tianjin Medical University, Tianjin, China.
authors: Huijuan
authors: H
authors: Jiang
authors: Rong
authors: R
authors: Fu
authors: Huaquan
authors: H
authors: Wang
authors: Lijuan
authors: L
authors: Li
authors: Hui
authors: H
authors: Liu
authors: Zonghong
authors: Z
authors: Shao
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism; D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood / Q000378:metabolism; D018952:Antigens, CD34 / Q000378:metabolism; D001854:Bone Marrow Cells / Q000378:metabolism; D051928:CD47 Antigen / Q000378:metabolism*; D004900:Erythroblasts / Q000378:metabolism*; D004906:Erythrocyte Count; D005260:Female; D005434:Flow Cytometry; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism; D012307:Risk Factors; D055815:Young Adult
chemical_list: D018952:Antigens, CD34; D051928:CD47 Antigen; D051997:ADP-ribosyl Cyclase 1