title: GSTT1 null genotype contributes to lung cancer risk in asian populations: a meta-analysis of 23 studies.
abstract: BACKGROUND
  Genetic variation in glutathione S-transferases (GSTs) may contribute to lung cancer risk. Many studies have investigated the correlation between the Glutathione S-transferase T1 (GSTT1) null genotype and lung cancer risk in Asian population but yielded inconclusive results.
  
  
  RESULTS
  We performed a meta-analysis of 23 studies including 4065 cases and 5390 controls. We assessed the strength of the association of GSTT1 with lung cancer risk and performed sub-group analyses by source of controls, smoking status, histological types, and sample size. A statistically significant correlation between GSTT1 null genotype and lung cancer in Asian population was observed (OR = 1.28, 95% CI = 1.10, 1.49; Pheterogeneity<0.001 and I(2) = 62.0%). Sub-group analysis revealed there was a statistically increased lung cancer risk in ever-smokers who carried the GSTT1 null genotype (OR = 1.94, 95% CI = 1.27, 2.96; P heterogeneity = 0.02 and I(2) = 58.1%). It was also indicated that GSTT1 null genotype could increase lung cancer risk among population-based studies (OR = 1.25, 95% CI = 1.04, 1.50; Pheterogeneity = 0.003 and I(2) = 56.8%). The positive association was also found in studies of sample size (≤500 participants) (OR = 1.34, 95% CI = 1.10, 1.62; Pheterogeneity<0.001 and I(2) = 65.4%).
  
  
  CONCLUSIONS
  These meta-analysis results suggest that GSTT1 null genotype is associated with a significantly increased risk of lung cancer in Asian population.
authors: The First Clinical College of Nanjing Medical University, Nanjing, China.
authors: Xin
authors: X
authors: Yang
authors: Man-Tang
authors: MT
authors: Qiu
authors: Jing-Wen
authors: JW
authors: Hu
authors: Xiao-Xiao
authors: XX
authors: Wang
authors: Feng
authors: F
authors: Jiang
authors: Rong
authors: R
authors: Yin
authors: Lin
authors: L
authors: Xu
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D017594:Publication Bias; D018401:Sample Size; D012907:Smoking
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase
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