title: Molecular understanding of curcumin in diabetic nephropathy.
abstract: Diabetic nephropathy is characterized by a plethora of signaling abnormalities. Recent trials have suggested that intensive glucose-lowering treatment leads to hypoglycemic events, which can be dangerous. Curcumin is the active ingredient of turmeric, which has been widely used in many countries for centuries to treat numerous diseases. The preventive and therapeutic properties of curcumin are associated with its antioxidant and anti-inflammatory properties. Here, we highlight the renoprotective role of curcumin in diabetes mellitus (DM) with an emphasis on the molecular basis of this effect. We also briefly discuss the numerous approaches that have been undertaken to improve the pharmacokinetics of curcumin.
authors: Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City 956-8603, Japan. vivian_09st@yahoo.com
authors: Vivian
authors: V
authors: Soetikno
authors: Kenji
authors: K
authors: Suzuki
authors: Punniyakoti T
authors: PT
authors: Veeraveedu
authors: Somasundaram
authors: S
authors: Arumugam
authors: Arun P
authors: AP
authors: Lakshmanan
authors: Hirohito
authors: H
authors: Sone
authors: Kenichi
authors: K
authors: Watanabe
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000379:methods; D003474:Curcumin / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003474:Curcumin