title: Drug-loaded fluorescent cubosomes: versatile nanoparticles for potential theranostic applications.
abstract: In this work, monoolein-based cubosomes were doped with two fluorescent probes, namely, fluorescein and dansyl, properly modified with a hydrocarbon chain to increase their encapsulation efficiency within the monoolein palisade. The same nanocarriers were also loaded with quercetin, a hydrophobic molecule with potential anticancer activity. Particularly, the cubosomes doped with the modified fluorescein probe were successfully exploited for single living cell imaging. The physicochemical and photophysical characterizations reported here, along with the well-known ability of cubosomes in hosting molecules with pharmaceutical interest, strongly encourage the use of these innovative fluorescent nanocarriers for theranostic purposes.
authors: Dipartimento di Scienze Chimiche e Geologiche, Università di Cagliari, Monserrato (CA), Italy. murgias@unica.it
authors: Sergio
authors: S
authors: Murgia
authors: Sara
authors: S
authors: Bonacchi
authors: Angela M
authors: AM
authors: Falchi
authors: Sandrina
authors: S
authors: Lampis
authors: Vito
authors: V
authors: Lippolis
authors: Valeria
authors: V
authors: Meli
authors: Maura
authors: M
authors: Monduzzi
authors: Luca
authors: L
authors: Prodi
authors: Judith
authors: J
authors: Schmidt
authors: Yeshayahu
authors: Y
authors: Talmon
authors: Claudia
authors: C
authors: Caltagirone
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004339:Drug Compounding / Q000379:methods; D019793:Fluorescein; D005456:Fluorescent Dyes; D005989:Glycerides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008856:Microscopy, Fluorescence; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010713:Phosphatidylcholines; D057285:Precision Medicine; D011794:Quercetin / Q000494:pharmacology; D059010:Single-Cell Analysis
chemical_list: C496906:1-myristoyl-2-(12-((5-dimethylamino-1-naphthalenesulfonyl)amino)dodecanoyl)-sn-glycero-3-phosphocholine; D000972:Antineoplastic Agents, Phytogenic; D005456:Fluorescent Dyes; D005989:Glycerides; D010713:Phosphatidylcholines; D011794:Quercetin; C005953:monoolein; D019793:Fluorescein