title: Discovering what makes STAT signaling TYK in T-ALL.
abstract: RNA interference screening establishes TYK2 dependence in T-cell acute lymphoblastic leukemia (T-ALL), leading to identification of TYK2-activating mutations and increased IL-10 receptor signaling in T-ALL cell lines. Cancer Discov; 3(5); 494-6. ©2013 AACR.
authors: Department of Medicine and Pharmacology, Weill Cornell Medical College, New York, NY, USA.
authors: Lorena
authors: L
authors: Fontan
authors: Ari
authors: A
authors: Melnick
mesh_terms: D000818:Animals; D006801:Humans; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D050794:STAT1 Transcription Factor / Q000378:metabolism*; D053634:TYK2 Kinase / Q000378:metabolism*
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D053634:TYK2 Kinase