title: Invariant NKT cells induce plasmacytoid dendritic cell (DC) cross-talk with conventional DCs for efficient memory CD8+ T cell induction.
abstract: A key goal of vaccine immunotherapy is the generation of long-term memory CD8(+) T cells capable of mediating immune surveillance. We discovered a novel intercellular pathway governing the development of potent memory CD8(+) T cell responses against cell-associated Ags that is mediated through cross-presentation by XCR1(+) dendritic cells (DCs). Generation of CD8(+) memory T cells against tumor cells pulsed with an invariant NKT cell ligand depended on cross-talk between XCR1(+) and plasmacytoid DCs that was regulated by IFN-α/IFN-αR signals. IFN-α production by plasmacytoid DCs was stimulated by an OX40 signal from the invariant NKT cells, as well as an HMGB1 signal from the dying tumor cells. These findings reveal a previously unknown pathway of intercellular collaboration for the generation of tumor-specific CD8(+) memory T cells that can be exploited for strategic vaccination in the setting of tumor immunotherapy.
authors: Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology, The Institute of Physical and Chemical Research, RIKEN, Yokohama, Kanagawa 230-0045, Japan.
authors: Kanako
authors: K
authors: Shimizu
authors: Miki
authors: M
authors: Asakura
authors: Jun
authors: J
authors: Shinga
authors: Yusuke
authors: Y
authors: Sato
authors: Shuji
authors: S
authors: Kitahara
authors: Katsuaki
authors: K
authors: Hoshino
authors: Tsuneyasu
authors: T
authors: Kaisho
authors: Stephen P
authors: SP
authors: Schoenberger
authors: Taichi
authors: T
authors: Ezaki
authors: Shin-ichiro
authors: S
authors: Fujii
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology*; D045744:Cell Line, Tumor; D002633:Chemotaxis / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D007156:Immunologic Memory; D007370:Interferon Type I / Q000276:immunology / Q000378:metabolism; D018664:Interleukin-12 / Q000096:biosynthesis; D008024:Ligands; D051379:Mice; D055611:Natural Killer T-Cells / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology; D015398:Signal Transduction
chemical_list: D007370:Interferon Type I; D008024:Ligands; D018664:Interleukin-12