title: Structural diversity of eukaryotic membrane cytochrome p450s.
abstract: X-ray crystal structures are available for 29 eukaryotic microsomal, chloroplast, or mitochondrial cytochrome P450s, including two non-monooxygenase P450s. These structures provide a basis for understanding structure-function relations that underlie their distinct catalytic activities. Moreover, structural plasticity has been characterized for individual P450s that aids in understanding substrate binding in P450s that mediate drug clearance.
authors: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA. johnson@scripps.edu
authors: Eric F
authors: EF
authors: Johnson
authors: C David
authors: CD
authors: Stout
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000378:metabolism; D020134:Catalytic Domain; D002462:Cell Membrane / Q000201:enzymology*; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008658:Inactivation, Metabolic; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D021381:Protein Transport
chemical_list: D002273:Carcinogens; D008565:Membrane Proteins; D003577:Cytochrome P-450 Enzyme System
keywords: Carcinogenesis; Cytochrome P450; Drug Development; Drug Metabolism; Protein structure; Steroidogenesis
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