title: Luminescent cell-penetrating pentadecanuclear lanthanide clusters.
abstract: A novel pentadecanuclear lanthanide hydroxy cluster [{Ln15(μ3-OH)20(PepCO2)10(DBM)10Cl}Cl4] (Ln = Eu (1), Tb (2)) featuring the first example with peptoids as supporting ligands was prepared and fully characterized. The solid-state structures of 1 and 2 were established via single-crystal X-ray crystallography. ESI-MS experiments revealed the retention of the cluster core in solution. Although OH groups are present, 1 showed intense red fluorescence with 11(1)% absolute quantum yield, whereas the emission intensity and the quantum yield of 2 were significantly weaker. In vitro investigations on 1 and 2 with HeLa tumor cells revealed an accumulation of the clusters in the endosomal-lyosomal system, as confirmed by confocal microscopy in the TRLLM mode. The cytotoxicity of 1 and 2 toward the HeLa cells is moderate.
authors: Institute of Inorganic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.
authors: Dominique T
authors: DT
authors: Thielemann
authors: Anna T
authors: AT
authors: Wagner
authors: Esther
authors: E
authors: Rösch
authors: Dominik K
authors: DK
authors: Kölmel
authors: Joachim G
authors: JG
authors: Heck
authors: Birgit
authors: B
authors: Rudat
authors: Marco
authors: M
authors: Neumaier
authors: Claus
authors: C
authors: Feldmann
authors: Ute
authors: U
authors: Schepers
authors: Stefan
authors: S
authors: Bräse
authors: Peter W
authors: PW
authors: Roesky
mesh_terms: D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D049449:Luminescence; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds