title: Nutritional supplements and plasma antioxidants in childhood asthma.
abstract: OBJECTIVE
  This study investigated the relationship of plasma antioxidants to airway inflammation and systemic oxidative stress in children suffering from atopic asthma with consideration of the intake of nutritional supplements.
  A total of 35 asthmatic children (AG) and 21 healthy controls (CG) participated in this study. Plasma levels of vitamins A and E, β-carotene, coenzyme Q10 and malondialdehyde (MDA) were analyzed with high-performance liquid chromatography (HPLC); the total antioxidant capacity (TAC) was measured photometrically, and selenium was determined by atomic absorption spectroscopy (AAS). The volume of fractionated exhaled nitric oxide (FeNO) was measured with the NIOX nitric oxide monitoring system.
  
  
  RESULTS
  The plasma antioxidants vitamins A and E, selenium, and coenzyme Q10 but not β-carotene were significantly (p < 0.05) lower in asthmatics than in controls. Further, asthmatic children had significantly reduced plasma concentrations of TAC (p < 0.01), significantly enhanced levels of MDA (p < 0.001), and exhaled a significantly (p < 0.001) higher mean volume of FENO than healthy children. Regular intake of supplements had a significant positive influence on plasma vitamin E (p < 0.01), selenium (p < 0.01), TAC (p < 0.05), MDA (p < 0.01), and FENO (p < 0.01) in asthmatics but not in controls. Additionally, significant negative associations of vitamin E and MDA (AG: p < 0.01; CG: p < 0.05), and vitamin E and FENO (AG: p < 0.05; CG: p > 0.05) were identified.
  
  
  CONCLUSIONS
  These results indicate that nutritional supplements beneficially modulate plasma antioxidants and thus might have a positive influence on systemic redox balance and subsequently, pulmonary inflammation in asthmatic children.
authors: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. elisabeth.fabian@medunigraz.at
authors: Elisabeth
authors: E
authors: Fabian
authors: Peter
authors: P
authors: Pölöskey
authors: Lajos
authors: L
authors: Kósa
authors: Ibrahim
authors: I
authors: Elmadfa
authors: Lajos Attila
authors: LA
authors: Réthy
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D001249:Asthma / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism*; D002648:Child; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011014:Pneumonia / Q000150:complications / Q000378:metabolism* / Q000517:prevention & control*; D017382:Reactive Oxygen Species
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species
references: Epidemiol Rev. 2001;23(2):268-87
references: 12192737
references: Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L246-55
references: 12114185
references: J Asthma. 2011 May;48(4):351-7
references: 21401389
references: Clin Exp Allergy. 2000 May;30(5):615-27
references: 10792352
references: Ann Clin Lab Sci. 2007 Winter;37(1):96-101
references: 17311877
references: J Asthma. 2005 Feb;42(1):45-50
references: 15801328
references: Antioxid Redox Signal. 2008 Apr;10(4):785-97
references: 18177234
references: J Immunol. 2007 Sep 1;179(5):3258-67
references: 17709542
references: Allergy. 2001 Jan;56(1):43-9
references: 11167351
references: J Appl Physiol (1985). 2009 Oct;107(4):1285-92
references: 19628725
references: Antioxid Redox Signal. 2008 Apr;10(4):769-83
references: 18179361
references: Am J Respir Crit Care Med. 2002 Sep 1;166(5):703-9
references: 12204869
references: Biochim Biophys Acta. 2006 Aug;1762(8):732-41
references: 16919916
references: Atherosclerosis. 1995 Jan 6;112(1):91-9
references: 7772072
references: Pharmacol Ther. 2006 Aug;111(2):476-94
references: 16458359
references: Free Radic Biol Med. 2003 Nov 1;35(9):1018-27
references: 14572605
references: Free Radic Biol Med. 2005 Aug 15;39(4):520-31
references: 16043023
references: Immunol Today. 1998 Aug;19(8):342-5
references: 9709500
references: Methods Enzymol. 1994;234:279-93
references: 7808295
references: Clin Chem Lab Med. 2003 Feb;41(2):200-2
references: 12667007
references: Am J Respir Crit Care Med. 2002 Dec 15;166(12 Pt 2):S31-7
references: 12471086
references: Inflammation. 2008 Dec;31(6):428-33
references: 18989765
references: Free Radic Biol Med. 2002 Aug 1;33(3):379-86
references: 12126760
references: Am J Respir Cell Mol Biol. 2006 May;34(5):592-9
references: 16399954
references: Am J Epidemiol. 2004 Feb 15;159(4):351-7
references: 14769638
references: J Allergy Clin Immunol. 2008 Jul;122(1):78-85
references: 18485467
references: Curr Opin Cell Biol. 1998 Apr;10(2):248-53
references: 9561849
references: Am J Clin Nutr. 1993 Aug;58(2):192-7
references: 8338047
references: Bratisl Lek Listy. 2002;103(10):353-6
references: 12583504
references: Eur J Clin Invest. 2010 Jan;40(1):35-53
references: 20055895
references: J Asthma. 2004 Apr;41(2):179-87
references: 15115170
references: Lancet. 2000 Nov 4;356(9241):1573-4
references: 11075775
references: Free Radic Biol Med. 2003 Aug 1;35(3):213-25
references: 12885584
references: Science. 2003 May 30;300(5624):1439-43
references: 12775843
references: Cell Mol Life Sci. 2005 Nov;62(21):2414-37
references: 16231092
references: Thorax. 2004 Feb;59(2):170-3
references: 14760161
references: Ther Adv Respir Dis. 2008 Aug;2(4):215-35
references: 19124374
references: Curr Opin Cell Biol. 2005 Apr;17(2):183-9
references: 15780595
references: Am J Respir Crit Care Med. 1994 Jun;149(6):1518-25
references: 8004308
references: J Allergy Clin Immunol. 2002 Sep;110(3):349-56
references: 12209079
references: Biol Trace Elem Res. 2004 Jan;97(1):31-41
references: 14742898
references: Am J Clin Nutr. 2003 Sep;78(3):414-21
references: 12936923
references: J Immunol. 2003 Mar 1;170(5):2670-9
references: 12594296
references: Eur Respir J. 2001 Mar;17(3):436-43
references: 11405522
references: J Asthma. 2009 Sep;46(7):699-702
references: 19728208
references: Eur J Pharmacol. 2006 Mar 8;533(1-3):240-52
references: 16464450
references: Am J Respir Crit Care Med. 2004 Feb 1;169(3):393-8
references: 14630617
references: Br J Nutr. 2001 May;85 Suppl 2:S67-74
references: 11509092