title: Communication of genome regulatory elements in a folded chromosome.
abstract: The most popular model of gene activation by remote enhancers postulates that the enhancers interact directly with target promoters via the looping of intervening DNA fragments. This interaction is thought to be necessary for the stabilization of the Pol II pre-initiation complex and/or for the transfer of transcription factors and Pol II, which are initially accumulated at the enhancer, to the promoter. The direct interaction of enhancer(s) and promoter(s) is only possible when these elements are located in close proximity within the nuclear space. Here, we discuss the molecular mechanisms for maintaining the close proximity of the remote regulatory elements of the eukaryotic genome. The models of an active chromatin hub (ACH) and an active nuclear compartment are considered, focusing on the role of chromatin folding in juxtaposing remote DNA sequences. The interconnection between the functionally dependent architecture of the interphase chromosome and nuclear compartmentalization is also discussed.
authors: Institute of Gene Biology of the Russian Academy of Sciences, 119334 Moscow, Russia. sergey.v.razin@inbox.ru
authors: Sergey V
authors: SV
authors: Razin
authors: Alexey A
authors: AA
authors: Gavrilov
authors: Elena S
authors: ES
authors: Ioudinkova
authors: Olga V
authors: OV
authors: Iarovaia
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D002877:Chromosomes, Human / Q000378:metabolism*; D004843:Epistasis, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D008957:Models, Genetic; D009690:Nucleic Acid Conformation
chemical_list: D002843:Chromatin