title: Benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine, a prolyl endopeptidase inhibitor, modulates depression-like behavior of rats in forced swimming test and activities of proline-specific peptidases in the brain structures.
abstract: High activities of prolyl endopeptidase and dipeptidylpeptidase IV in the striatum and of prolyl endopeptidase in the frontal cortex were recorded in rats with stress-induced depression-like state (behavioral despair) developed in the Porsolt forced swimming test. Acute injection of benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine (prolyl endopeptidase noncompetitive synthetic inhibitor) in a dose of 1 mg/kg prevented the development of behavioral despair and the increase of prolyl endopeptidase and dipeptidylpeptidase IV activities in the brain structures. In a dose of 2 mg/kg prolyl endopeptidase inhibitor did not modify the development of behavioral despair, but prevented the increase of prolyl endopeptidase and dipeptidylpeptidase IV activities in the striatum.
authors: Laboratory of the Nervous System General Pathology, Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences, Moscow, Russia. krupina-na@yandex.ru
authors: N A
authors: NA
authors: Krupina
authors: N G
authors: NG
authors: Bogdanova
authors: N N
authors: NN
authors: Khlebnikova
authors: N N
authors: NN
authors: Zolotov
authors: G N
authors: GN
authors: Kryzhanovskii
mesh_terms: D000626:Aminopeptidases / Q000378:metabolism; D000818:Animals; D001007:Anxiety / Q000188:drug therapy*; D001921:Brain / Q000201:enzymology*; D002525:Cerebellar Cortex / Q000201:enzymology; D003342:Corpus Striatum / Q000201:enzymology; D003863:Depression / Q000188:drug therapy* / Q000201:enzymology; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D000085822:Prolyl Oligopeptidases; D011759:Pyrrolidines / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012697:Serine Endopeptidases / Q000378:metabolism*; D013315:Stress, Psychological
chemical_list: D011759:Pyrrolidines; C543067:benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine; D008715:Methionine; D000626:Aminopeptidases; D018819:Dipeptidyl Peptidase 4; C545245:Dpp4 protein, mouse; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases