title: Overexpression of IL-9 receptor in diffuse large B-cell lymphoma.
abstract: Interleukin-9 (IL-9) is initially described as a growth factor secreted by helper T cells. It acts on a variety of immune cells via its receptor (IL-9R). Recently, the oncogenic activities of IL-9 and IL-9R were reported in some lymphomas but not diffuse large B-cell lymphoma (DLBCL). The purpose of the present study is to investigate the expression of IL-9R in pathological tissues from patients with DLBCL and to evaluate its correlation with clinical characteristics. Tissue samples from patients with DLBCL and reactive lymphoid hyperplasia were analyzed using RT-PCR, western blot and immunohistochemical staining. There was a higher expression of IL-9R within DLBCL tissues compared with hyperplasic lymph nodes. Immunohistochemical analysis indicated membrane localization of IL-9R in 22 of 36 (61.1%) DLBCL cases. The upregulated IL-9R was correlated to the serum levels of β2 microglobulin and albumin, International Prognostic Index (IPI) score as well as Ki-67 expression within tumor tissues. Our findings suggest that overexpression of IL-9R may contribute to the pathogenesis of DLBCL and is associated with some adverse prognostic parameters.
authors: Department of Hematology, Provincial Hospital affiliated to Shandong University, Jinan, China.
authors: Xiao
authors: X
authors: Lv
authors: Lili
authors: L
authors: Feng
authors: Xiaosheng
authors: X
authors: Fang
authors: Yujie
authors: Y
authors: Jiang
authors: Xin
authors: X
authors: Wang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D015153:Blotting, Western; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D053651:Receptors, Interleukin-9 / Q000032:analysis / Q000096:biosynthesis*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D053651:Receptors, Interleukin-9
keywords: IL-9 receptor; diffuse large B-cell lymphoma; prognosis
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