title: PC3 (BTG2/TIS21) possible role in chromosome instability syndromes.
abstract: Chromosome instability syndromes (CIS) are autosomal recessive genetic disorders associated with defects in cell cycle regulation following DNA damage. Although most of the proteins involved in these syndromes have been identified as part of the MRN complex, little is known about their physiological functions and their interactions with other molecules that might explain the wide clinical presentation found in CIS patients. Here we discuss several observations suggesting that PC3 (BTG2/TIS21) - a protein involved in G1-S checkpoint progression control - might play a role in these pathologies.
authors: Equipe Infections, Genre et Grossesse, URMITE-IRD198, CNRS UMR7278, INSERM U1095, Faculté de Médecine, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France. filippo.conti@gmail.com
authors: Filippo
authors: F
authors: Conti
authors: Eric
authors: E
authors: Ghigo
mesh_terms: D018797:Cell Cycle Proteins / Q000737:chemistry*; D043171:Chromosomal Instability; D004249:DNA Damage; D006801:Humans
chemical_list: D018797:Cell Cycle Proteins