title: Percutaneous autologous bone marrow injections for delayed or non-union of bones.
abstract: OBJECTIVE
  To evaluate 12 patients with delayed or nonunion of bones treated with bone marrow injections.
  
  
  METHODS
  6 men and 6 women aged 15 to 70 (mean, 45) years underwent bone marrow injections for delayed union (n=2) or atrophic non-union (n=10) of the ulna (n=6), femur (n=3), humerus (n=2), or metacarpal (n=1). Bone marrow was aspirated from the anterior iliac crest and injected to the delayed and non-union sites. Two injections were given for children and adolescents, and 3 for adults. The interval between the injections was 6 to 8 weeks. The amount of bone marrow injected was 30 to 40 ml for long bones and 20 ml for metacarpals.
  
  
  RESULTS
  Ten of the 12 delayed or non-union of bones healed after bone marrow injections. The mean time for callus formation was 5.8 (range, 3-10) weeks, for clinical union was 7 (range, 4-12) weeks, and for radiological union was 16 (range, 10-24) weeks.
  
  
  CONCLUSIONS
  Multiple injections of low-volume bone marrow can be used for treatment of delayed or non-union of bones.
authors: Department of Trauma and Orthopaedics, King's College Hospital, London, United Kingdom. ashoksingh03@yahoo.co.uk
authors: Ashok K
authors: AK
authors: Singh
authors: Sanat
authors: S
authors: Shetty
authors: Jayadeep J
authors: JJ
authors: Saraswathy
authors: Amit
authors: A
authors: Sinha
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D017102:Fracture Healing; D005599:Fractures, Ununited / Q000601:surgery*; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D055815:Young Adult
keywords: bone marrow; bone matrix; injections; platelet-rich plasma