title: Central corneal regularization--optimization of uncorrected visual acuity in keratoconus patients.
abstract: BACKGROUND
  Combined excimer laser correction and corneal cross-linking is a promising concept in treating keratoconus patients. Central corneal regularization represents advanced topography-guided custom ablation for ectatic corneas, aiming at correcting irregular astigmatism and at increasing the optical regularity of the corneal surface.
  
  
  METHODS
  In a prospective single centre study, 10 keratoconus patients underwent combined treatment with corneal cross-linking and central corneal regularization by an iRES-Laser. Uncorrected visual acuity at 1 and 3 months postoperatively represented the primary endpoint.
  
  
  RESULTS
  Mean preoperative uncorrected decimal visual acuity was 0.15 (± 0.28 standard deviation). Mean postoperative visual acuity was 0.28 (± 0.47) at one month and 0.24 (± 0.25) at three months, respectively.
  
  
  CONCLUSIONS
  Combined corneal cross-linking and central corneal regularization treatment has the potential to achieve a clinically significant improvement of uncorrected visual acuity.
authors: Dept. of Ophthalmology, Cantonal Hospital Lucerne, Lucerne, Switzerland. claude.kaufmann@luks.ch
authors: C
authors: C
authors: Kaufmann
authors: F
authors: F
authors: Bochmann
authors: P
authors: P
authors: Baenninger
authors: M A
authors: MA
authors: Thiel
mesh_terms: D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy / Q000379:methods; D019781:Corneal Topography / Q000379:methods*; D003432:Cross-Linking Reagents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D020731:Keratomileusis, Laser In Situ / Q000379:methods*; D054018:Lasers, Excimer / Q000627:therapeutic use*; D008297:Male; D013813:Therapy, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D003432:Cross-Linking Reagents