title: Pharmacology of the new target-specific oral anticoagulants.
abstract: Oral anticoagulation therapy is transforming with the advent of the target specific oral anticoagulants, particularly, the direct thrombin inhibitors and factor Xa inhibitors. These agents have demonstrated clinical efficacy and safety and offer several potential advantages over current standard of care therapy, warfarin. Nevertheless, the pharmacology between the newly approved oral anticoagulants differs and must be considered for appropriate management and patient selection. The pharmacodynamics and pharmacokinetics of dabigatran etexilate, rivaroxaban, apixaban and edoxaban are discussed in detail, which may translate into considerable clinical implications.
authors: Department Pharmacy Practice, Albany College of Pharmacy and Health Sciences, 106 New Scotland Ave., Albany, NY 12208, USA. katherine.cabral@acphs.edu
authors: Katherine P
authors: KP
authors: Cabral
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000925:Anticoagulants / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D065427:Factor Xa Inhibitors; D006801:Humans; D013917:Thrombin / Q000037:antagonists & inhibitors*
chemical_list: D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D013917:Thrombin
references: J Clin Pharmacol. 2010 Jul;50(7):743-53
references: 20081065
references: J Thromb Haemost. 2008 Sep;6(9):1542-9
references: 18624979
references: Drug Metab Dispos. 2008 Feb;36(2):386-99
references: 18006647
references: J Med Chem. 2002 Apr 25;45(9):1757-66
references: 11960487
references: Clin Pharmacokinet. 2003;42(1):59-98
references: 12489979
references: Drugs. 2011 Aug 20;71(12):1503-26
references: 21861537
references: Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1885-9
references: 20671233
references: Drug Metab Dispos. 2009 Jan;37(1):74-81
references: 18832478
references: Am Heart J. 2010 Oct;160(4):635-41
references: 20934556
references: J Thromb Haemost. 2005 Mar;3(3):514-21
references: 15748242
references: N Engl J Med. 2005 Sep 8;353(10):1028-40
references: 16148288
references: Int J Clin Pract. 2010 Jun;64(7):956-67
references: 20584229
references: Br J Clin Pharmacol. 2007 Sep;64(3):292-303
references: 17506785
references: Am J Cardiovasc Drugs. 2005;5(5):279-90
references: 16156684
references: Br J Clin Pharmacol. 2013 Feb;75(2):476-87
references: 22759198
references: Am J Health Syst Pharm. 2008 Aug 15;65(16):1520-9
references: 18693206
references: Eur J Clin Pharmacol. 2005 Dec;61(12):873-80
references: 16328318
references: Clin Pharmacokinet. 2010 Apr;49(4):259-68
references: 20214409
references: Clin Pharmacokinet. 2009;48(1):1-22
references: 19071881
references: Lancet. 2003 Nov 22;362(9397):1691-8
references: 14643116
references: J Clin Pharmacol. 2006 May;46(5):549-58
references: 16638738
references: N Engl J Med. 2011 Sep 15;365(11):981-92
references: 21870978
references: J Clin Pharmacol. 2011 May;51(5):687-94
references: 20534818
references: Am J Kidney Dis. 2013 Mar;61(3):487-9
references: 23219111
references: J Thromb Thrombolysis. 2006 Feb;21(1):67-72
references: 16475045
references: JAMA. 2005 Feb 9;293(6):690-8
references: 15701910
references: Curr Med Chem. 2001 Feb;8(2):101-19
references: 11172669
references: J Thromb Haemost. 2010 Sep;8(9):2069-70
references: 20553377
references: Clin Pharmacokinet. 2008;47(5):285-95
references: 18399711
references: Thromb Haemost. 2010 Mar;103(3):572-85
references: 20135071
references: J Thromb Thrombolysis. 2011 Apr;31(3):326-43
references: 21359645
references: Drug Metab Dispos. 2010 Mar;38(3):448-58
references: 19940026
references: Clin Pharmacokinet. 2008;47(1):47-59
references: 18076218
references: J Pharmacol Exp Ther. 2002 Oct;303(1):323-32
references: 12235267
references: J Thromb Haemost. 2007 Jun;5(6):1237-42
references: 17362226
references: N Engl J Med. 2009 Sep 17;361(12):1139-51
references: 19717844
references: Br J Clin Pharmacol. 2015 May;79(5):838-46
references: 25377242
references: Clin Pharmacol Ther. 2005 Oct;78(4):412-21
references: 16198660
references: J Clin Pharmacol. 2008 Dec;48(12):1411-9
references: 18827075