title: Bridges between Cell Cycle Regulation and Self-Renewal Maintenance.
abstract: Stem cells are a unique population that lies at the summit of any, or at least most, biological systems. They can differentiate in a variety of mature cell types, but they also have the ability to self-renew, that is, the capacity to divide and retain all the features of the mother cell. The regulation of self-renewal has been studied for many years, but several aspects of this regulation are still vague. The combined decision to divide and self-renew or differentiate suggests that the mechanisms that regulate self-renewal and cell cycle activity are intermingled. While inactivation of many cell cycle regulators impacts the physiological and pathological biology of stem cells, the exact mechanisms that link the decision to enter the cell cycle and the choice of the cellular fate are poorly understood. The multiplicity of signals and pathways regulating self-renewal add to the complexity of the phenomenon. Here, I will review the described links between the cell cycle and self-renewal and discuss the role of the niche in the regulation of both mechanisms.
authors: Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, USA ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors: Patrick
authors: P
authors: Viatour
keywords: ES cells; HSCs; cell cycle; self-renewal
references: Nat Genet. 2007 Mar;39(3):380-5
references: 17259983
references: Science. 2008 Apr 4;320(5872):97-100
references: 18292307
references: Nat Rev Cancer. 2008 Sep;8(9):671-82
references: 18650841
references: Mol Cell. 2007 Jun 8;26(5):745-52
references: 17540599
references: Cell Stem Cell. 2007 Dec 13;1(6):685-97
references: 18371409
references: Stem Cells. 2011 Feb;29(2):376-85
references: 21732494
references: Cell. 2008 Aug 8;134(3):521-33
references: 18692474
references: Nat Immunol. 2010 Mar;11(3):207-15
references: 20081848
references: Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):69-74
references: 20018659
references: Nat Cell Biol. 2004 May;6(5):436-42
references: 15122268
references: Cell. 2008 Feb 22;132(4):567-82
references: 18295576
references: Stem Cells. 2007 Apr;25(4):836-43
references: 17170062
references: Cell Cycle. 2012 Jun 1;11(11):2063-72
references: 22580472
references: J Exp Med. 2006 Oct 2;203(10):2247-53
references: 16954369
references: Cell. 2008 Jun 27;133(7):1162-74
references: 18585351
references: J Clin Invest. 2010 Jun;120(6):2058-69
references: 20458146
references: Nat Biotechnol. 2011 May;29(5):443-8
references: 21490602
references: Exp Hematol. 2011 May;39(5):511-20
references: 21288477
references: Cell Stem Cell. 2008 Apr 10;2(4):356-66
references: 18397755
references: Nature. 2004 Oct 21;431(7011):1002-7
references: 15457180
references: EMBO J. 2012 May 2;31(9):2067-75
references: 22433839
references: Science. 1998 Nov 6;282(5391):1145-7
references: 9804556
references: Nat Genet. 2008 Dec;40(12):1478-83
references: 18978791
references: Nat Rev Genet. 2008 Feb;9(2):115-28
references: 18202695
references: Cell Stem Cell. 2010 Aug 6;7(2):198-213
references: 20682446
references: Genes Dev. 1998 Jul 1;12(13):2048-60
references: 9649508
references: Cell. 2007 Jan 26;128(2):325-39
references: 17254970
references: Cell Stem Cell. 2011 Sep 2;9(3):262-71
references: 21885021
references: Annu Rev Biochem. 2012;81:737-65
references: 22443931
references: J Exp Med. 2011 Sep 26;208(10):1963-76
references: 21875955
references: Cell Stem Cell. 2012 Jun 14;10(6):690-697
references: 22704509
references: Nature. 2007 Aug 2;448(7153):553-60
references: 17603471
references: Clin Cancer Res. 2011 Aug 1;17(15):4936-41
references: 21593194
references: Cell Stem Cell. 2008 Jun 5;2(6):595-601
references: 18522852
references: Genes Dev. 2012 Jul 1;26(13):1409-20
references: 22751497
references: Cell Stem Cell. 2009 Jan 9;4(1):37-48
references: 19128791
references: Cell Stem Cell. 2008 May 8;2(5):484-96
references: 18462698
references: Nature. 2007 Jul 12;448(7150):196-9
references: 17597760
references: Nature. 2009 Aug 27;460(7259):1132-5
references: 19668191
references: Nature. 2006 Feb 2;439(7076):599-603
references: 16382241
references: Cell. 2003 Oct 31;115(3):281-92
references: 14636556
references: Nature. 2003 May 15;423(6937):255-60
references: 12714970
references: Nat Rev Mol Cell Biol. 2009 Feb;10(2):116-25
references: 19165214
references: Nature. 2009 Dec 3;462(7273):595-601
references: 19898493
references: Plant Cell. 2011 Jul;23(7):2581-91
references: 21742994
references: EMBO J. 2005 Jun 1;24(11):1976-87
references: 15889140
references: Curr Top Dev Biol. 1998;38:133-65
references: 9399078
references: J Clin Invest. 2008 Aug;118(8):2832-44
references: 18618018
references: Cell. 2007 Jun 15;129(6):1081-95
references: 17574022
references: Nat Cell Biol. 2009 Dec;11(12):1487-95
references: 19935649
references: Cell. 1995 May 5;81(3):323-30
references: 7736585
references: J Exp Med. 2011 Feb 14;208(2):251-60
references: 21282380
references: Cancer Cell. 2009 Apr 7;15(4):341-52
references: 19345332
references: Oncogene. 2008 Sep 11;27(40):5277-87
references: 18521083
references: Cell. 2007 Feb 23;128(4):735-45
references: 17320510
references: Biochem Biophys Res Commun. 2008 Feb 8;366(2):335-9
references: 18047833
references: Nature. 2006 Sep 28;443(7110):421-6
references: 16957735
references: Oncogene. 2002 Nov 28;21(54):8320-33
references: 12447695
references: J Exp Med. 2005 Dec 5;202(11):1599-611
references: 16330818
references: Nature. 1988 Dec 15;336(6200):684-7
references: 3143916
references: Exp Cell Res. 2011 Nov 15;317(19):2719-24
references: 21787769
references: Blood. 1998 Jul 1;92(1):4-10
references: 9639492
references: Blood. 2013 Feb 7;121(6):905-17
references: 23115273
references: Cell Stem Cell. 2011 Sep 2;9(3):247-61
references: 21885020
references: Cell Stem Cell. 2010 Jul 2;7(1):31-5
references: 20621047
references: Nat Med. 2006 Apr;12(4):446-51
references: 16565722
references: Cell. 2004 Jul 23;118(2):149-61
references: 15260986
references: J Exp Med. 2011 Mar 14;208(3):421-8
references: 21402747
references: Stem Cells. 2008 Oct;26(10):2496-505
references: 18583537
references: Nat Rev Immunol. 2011 Dec 23;12(1):49-60
references: 22193770
references: Trends Cell Biol. 2002 Sep;12(9):432-8
references: 12220864
references: Exp Cell Res. 2010 Sep 10;316(15):2434-46
references: 20542030
references: Cell Stem Cell. 2011 Sep 2;9(3):187-92
references: 21885016
references: Nature. 2007 Jun 28;447(7148):1130-4
references: 17554337
references: Nat Cell Biol. 2011 Aug 14;13(9):1070-5
references: 21841791
references: Development. 2005 Mar;132(5):885-96
references: 15673569
references: Immunity. 2002 Oct;17(4):437-49
references: 12387738
references: Cell. 2011 Jun 10;145(6):851-62
references: 21663791
references: J Biol Chem. 2009 Mar 20;284(12):7719-32
references: 19147501
references: Cell Stem Cell. 2008 Oct 9;3(4):416-28
references: 18940733
references: Mol Cell Biol. 2008 Oct;28(20):6426-38
references: 18710938
references: Nature. 2012 Jan 25;481(7382):457-62
references: 22281595
references: Cell Stem Cell. 2010 Mar 5;6(3):279-86
references: 20207230
references: Nat Rev Mol Cell Biol. 2007 Feb;8(2):149-60
references: 17245415
references: Genes Dev. 2004 Nov 15;18(22):2747-63
references: 15545632
references: Nat Cell Biol. 2005 Feb;7(2):165-71
references: 15619621
references: Annu Rev Cell Dev Biol. 2009;25:377-406
references: 19575646
references: Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12135-40
references: 16099834
references: Nat Med. 2012 Nov;18(11):1651-7
references: 23086476
references: Science. 2000 Mar 10;287(5459):1804-8
references: 10710306