title: A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.
abstract: A series of benzazepinones were synthesized and evaluated for block of Nav1.7 sodium channels. Compound 30 from this series displayed potent channel block, good selectivity versus other targets, and dose-dependent oral efficacy in a rat model of neuropathic pain.
authors: Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. scott_hoyt@merck.com
authors: Scott B
authors: SB
authors: Hoyt
authors: Clare
authors: C
authors: London
authors: Catherine
authors: C
authors: Abbadie
authors: John P
authors: JP
authors: Felix
authors: Maria L
authors: ML
authors: Garcia
authors: Nina
authors: N
authors: Jochnowitz
authors: Bindhu V
authors: BV
authors: Karanam
authors: Xiaohua
authors: X
authors: Li
authors: Kathryn A
authors: KA
authors: Lyons
authors: Erin
authors: E
authors: McGowan
authors: Birgit T
authors: BT
authors: Priest
authors: McHardy M
authors: MM
authors: Smith
authors: Vivien A
authors: VA
authors: Warren
authors: Brande S
authors: BS
authors: Thomas-Fowlkes
authors: Gregory J
authors: GJ
authors: Kaczorowski
authors: Joseph L
authors: JL
authors: Duffy
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D004195:Disease Models, Animal; D009437:Neuralgia / Q000188:drug therapy*; D051381:Rats; D026941:Sodium Channel Blockers / Q000494:pharmacology*
chemical_list: D001552:Benzazepines; D026941:Sodium Channel Blockers