title: Human cathelicidin peptide LL37 binds telomeric G-quadruplex.
abstract: Stabilization of G-quadruplex inhibits the activity of the enzyme telomerase in cancer cells. We found LL37, a host defense human cathelicidin antimicrobial peptide, to be a potent binder of G-quadruplex structures.
authors: Biomolecular NMR and Drug Design Laboratory, Department of Biophysics, Bose Institute, P-1/12 CIT Scheme VII M, Kolkata, India.
authors: Jagannath
authors: J
authors: Jana
authors: Rajiv Kumar
authors: RK
authors: Kar
authors: Anirban
authors: A
authors: Ghosh
authors: Atanu
authors: A
authors: Biswas
authors: Surajit
authors: S
authors: Ghosh
authors: Anirban
authors: A
authors: Bhunia
authors: Subhrangsu
authors: S
authors: Chatterjee
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000378:metabolism; D002942:Circular Dichroism; D054856:G-Quadruplexes; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011485:Protein Binding; D016615:Telomere / Q000737:chemistry* / Q000378:metabolism; D054804:Cathelicidins
chemical_list: D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins