title: Cancer. Silencing a metabolic oncogene.
authors: Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors: Jiyeon
authors: J
authors: Kim
authors: Ralph J
authors: RJ
authors: DeBerardinis
mesh_terms: D000818:Animals; D044482:Benzeneacetamides / Q000494:pharmacology*; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005910:Glioma / Q000201:enzymology* / Q000473:pathology*; D005977:Glutarates / Q000378:metabolism*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007521:Isocitrate Dehydrogenase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D007938:Leukemia / Q000201:enzymology*; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology*; D010671:Phenylurea Compounds / Q000494:pharmacology*; D011393:Procollagen-Proline Dioxygenase / Q000037:antagonists & inhibitors*; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: C581156:AGI-5198; C581155:AGI-6780; D044482:Benzeneacetamides; D004791:Enzyme Inhibitors; D005977:Glutarates; D007093:Imidazoles; D010671:Phenylurea Compounds; D013449:Sulfonamides; C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; D011393:Procollagen-Proline Dioxygenase
references: Science. 2013 Mar 29;339(6127):1621-5
references: 23393090
references: Biochemistry. 2011 May 31;50(21):4804-12
references: 21524095
references: Nature. 2009 Dec 10;462(7274):739-44
references: 19935646
references: J Inherit Metab Dis. 2012 Jul;35(4):571-87
references: 22391998
references: N Engl J Med. 2009 Feb 19;360(8):765-73
references: 19228619
references: Nature. 2012 Feb 15;483(7390):474-8
references: 22343901
references: Cancer Cell. 2010 Dec 14;18(6):553-67
references: 21130701
references: Science. 2013 Apr 12;340(6129):170-3
references: 23470733
references: Nature. 2012 Feb 15;483(7390):479-83
references: 22343889
references: Cancer Cell. 2011 Jan 18;19(1):17-30
references: 21251613