title: [Acute, severe liver insufficiency caused by extrahepatic biliary atresia in a newborn].
abstract: A newborn female was hospitalized due to metabolic acidosis and conjugated hyperbilirubinaemia. Extrahepatic biliary atresia (EHBA) was suspected why a (99m)Tc-mebrofenin cholescintigraphy was performed. It showed poor hepatocyte tracer uptake and no drainage to the gut. The hepatocyte dysfunction was caused by an obstructing adrenal gland neuroblastoma later visualised by ultrasound and MRI. The cholescintigraphy is a non-invasive modality to exclude or confirm the suspicion of EHBA. Furthermore neonatal conjugated hyperbilirubinaemia demands the use of a multimodality imaging strategy for differential diagnosis to EHBA.
authors: Klinik for Klinisk Fysiologi, Nuklearmedicin og PET, Righospitalet, Blegdamsvej 9, 2100 København Ø, Denmark. jane.ditlevsen@regionh.dk
authors: Jane
authors: J
authors: Maestri Ditlevsen
authors: Nina
authors: N
authors: Kvist
authors: Lars Søndergaard
authors: LS
authors: Johansen
authors: Marianne Hørby
authors: MH
authors: Jørgensen
authors: Birthe Merete
authors: BM
authors: Henriksen
authors: Catherine
authors: C
authors: Rechnitzer
authors: Ane
authors: A
authors: Lando
authors: Bodil Laub
authors: BL
authors: Petersen
authors: Liselotte
authors: L
authors: Højgaard
authors: Lise
authors: L
authors: Borgwardt
mesh_terms: D000208:Acute Disease; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D001656:Biliary Atresia / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D048550:Hepatic Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000209:etiology; D007231:Infant, Newborn; D009447:Neuroblastoma / Q000150:complications* / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid