title: A pooled analysis of diagnostic value of (99m)Tc-ubiquicidin (UBI) scintigraphy in detection of an infectious process.
abstract: OBJECTIVE
  Although the data are promising from limited studies with technetium-99m ubiquicidin (Tc-UBI) scintigraphy in detection of infection in humans, these studies have had a limited sample size. This study was conducted to provide a systematic review and meta-analysis of the reported diagnostic accuracy of Tc-UBI scintigraphy in detection of an infectious process.
  
  
  METHODS
  The PubMed/MEDLINE, Web of Science, EMBASE, and Google Scholar literature databases were systematically searched to find the relevant human studies on Tc-UBI scintigraphy. For each eligible study, the true-positive, false-positive, true-negative, and false-negative findings at Tc-UBI scintigraphy were recorded, and the overall statistical parameters were acquired.
  
  
  RESULTS
  Ten studies carried out from 2004 to 2010 were included in the analysis. The pooled data sensitivity was 94.5 % and with a 95% confidence interval of 91.2%-96.8%. The pooled specificity was still as high as about 92.7%. The range of reported specificity was from 80% to 100%. The overall accuracy was 93.7% (95% CI: 91.2%-95.7%).
  
  
  CONCLUSIONS
  The study demonstrated that Tc-UBI scintigraphy can be used to identify an infectious process with admirable accuracy in early views; however, further investigations are recommended.
authors: Department of Infectious Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.
authors: Afshin
authors: A
authors: Ostovar
authors: Mahsan
authors: M
authors: Assadi
authors: Katayoun
authors: K
authors: Vahdat
authors: Iraj
authors: I
authors: Nabipour
authors: Hamid
authors: H
authors: Javadi
authors: Mohammad
authors: M
authors: Eftekhari
authors: Majid
authors: M
authors: Assadi
mesh_terms: D006801:Humans; D007239:Infections / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D010446:Peptide Fragments; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity
chemical_list: D015609:Organotechnetium Compounds; D010446:Peptide Fragments; C485080:technetium 99m ubiquicidin(29-41)