title: Disseminated cryptococcosis with hepatic dysfuction as the initial manifestation in an immunocompetent adult.
abstract: Disseminated cryptococcosis is rare in immunocompetent hosts and hepatic manifestations as the presenting feature is further rare. We report a case of disseminated cryptococcosis with hepatic involvement as an initial manifestation in a previously healthy, immunocompetent adult. A young married female presented with progressive jaundice, anorexia, weightloss, cough with expectoration, and hepatosplenomegaly. Biochemical profile showed liver function derangement with increased transaminases, alkaline phosphatase, bilirubin with deranged coagulation assay, and decreased albumin. The patient was treated initially for disseminated tuberculosis with associated sepsis, but she succumbed on the third day. Diagnosis of cryptococcosis was made on the basis of sputum culture, serology, and liver histopathology.
authors: Department of Medicine, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India. anuspng@gmail.com
authors: Anurag
authors: A
authors: Rohtagi
authors: Anuradha
authors: A
authors: Aggarwal
authors: Mukesh Kumar
authors: MK
authors: Chabra
authors: Amol Sonyabapu
authors: AS
authors: Dahale
mesh_terms: D000328:Adult; D003453:Cryptococcosis / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006529:Hepatomegaly / Q000209:etiology*; D006801:Humans; D007121:Immunocompetence; D007565:Jaundice / Q000209:etiology*; D008099:Liver / Q000473:pathology*; D008168:Lung / Q000000981:diagnostic imaging; D011859:Radiography; D013163:Splenomegaly / Q000209:etiology*; D014376:Tuberculosis / Q000175:diagnosis