title: Statistic parametric mapping of changes in gene activity in animal brain during acoustic stimulation.
abstract: We analyzed the expression of transcription factor c-Fos induced by neural activity in the mouse brain after acoustic stimulation. The brain sections of the animals subjected to acoustic stimulation and controls were immunohistochemically stained for c-Fos protein. Statistical parametric mapping (SPM) was used to identify group differences in the acquired images. c-Fos expression was significantly higher in the auditory cortex, amygdala, and hippocampus CA3 area after tone presentation. The proposed combination of SPM with molecular-biological approach to visualization of transcription in the nerve cells makes it possible to identify the collaborative activation of distant brain structures assumed to be the components of united functional systems.
authors: Laboratory of Neurobiology of Memory, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Russia. e.amelchenko@gmail.com
authors: E M
authors: EM
authors: Amelchenko
authors: A A
authors: AA
authors: Osokin
authors: S V
authors: SV
authors: Zworikina
authors: S A
authors: SA
authors: Chekhov
authors: A E
authors: AE
authors: Lebedev
authors: P A
authors: PA
authors: Voronin
authors: V V
authors: VV
authors: Galatenko
authors: D P
authors: DP
authors: Vetrov
authors: K V
authors: KV
authors: Anokhin
mesh_terms: D000161:Acoustic Stimulation; D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D001303:Auditory Cortex / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D001931:Brain Mapping; D015870:Gene Expression; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism*
chemical_list: D016760:Proto-Oncogene Proteins c-fos