title: Nickel-catalyzed direct alkylation of heterocycles with α-bromo carbonyl compounds: C3-selective functionalization of 2-pyridones.
abstract: Nickel HAS it: A Ni(cod)2/dppp catalyst system promotes the direct alkylation of electron-rich heterocycles with α-bromo carbonyl compounds and involves an alkyl radical intermediate (see scheme; cod = 1,5-cyclooctadiene, dppp = 1,3-bis(diphenylphosphino)propane). This homolytic radical aromatic substitution (HAS)-type reaction enables the C3-selective direct functionalization of 2-pyridones.
authors: Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
authors: Akihiro
authors: A
authors: Nakatani
authors: Koji
authors: K
authors: Hirano
authors: Tetsuya
authors: T
authors: Satoh
authors: Masahiro
authors: M
authors: Miura
mesh_terms: D000478:Alkylation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry; D011407:Propane / Q000031:analogs & derivatives / Q000737:chemistry; D011728:Pyridones / Q000737:chemistry*
chemical_list: D006842:Hydrocarbons, Brominated; D010720:Phosphines; D011728:Pyridones; C467590:1,3-bis(diphenylphosphino)propane; C017679:2-hydroxypyridine; D009532:Nickel; D011407:Propane