title: Toll-like receptor (TLR) and matrix metalloproteinase (MMP) polymorphisms and periodontitis susceptibility: a meta-analysis.
abstract: The aim of this study was to determine whether the toll-like receptor (TLR) and matrix metalloproteinase (MMP) polymorphisms confers susceptibility to periodontitis in ethnically different populations. A literature search using PubMed and Embase provided the data to conduct a meta-analysis on the associations between the TLR2 Arg753Gln, TLR4 Asp299Gly, Thr399Ile, MMP-1 -1607 G1/G2 and MMP-9 -1562 C/T polymorphisms and periodontitis. A total of 32 studies (14 on TLR polymorphisms and 18 on MMP polymorphisms) were considered in the meta-analysis. The meta-analysis showed no association between periodontitis and the TLR2 753Arg allele (Odds ratio [OR]=0.962, 95% confidence interval [CI]=0.662-1.400, p=0.841). Meta-analysis of the TLR4 Asp299Gly and Thr399Ile polymorphisms showed no association between periodontitis and the TLR4 299Asp allele in all study subjects (OR=0.984, 95% CI=0.761-1.271, p=0.900; OR=1.030, 95% CI=0.748-1.418, p=0.854). Meta-analysis showed an association between the MMP-1 -1607 G2G2 genotype and periodontitis in Asians (OR=3.778, 95% CI=1.210-11.80, p=0.022). Meta-analysis containing only studies in Hardy-Weinberg equilibrium revealed no association between chronic periodontitis and the MMP-9 -1562TT genotype (OR=0.638, 95% CI=0.265-1.533, p=0.315). This meta-analysis demonstrates a lack of association between the TLR2 Arg753Gln, TLR4 Asp299Gly, Thr399Ile, MMP-9 -1562 C/T polymorphisms and periodontitis, but shows an association between the MMP-1 -1607 G2G2 genotype and periodontitis in Asians.
authors: Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, South Korea.
authors: Gwan Gyu
authors: GG
authors: Song
authors: Jae-Hoon
authors: JH
authors: Kim
authors: Young Ho
authors: YH
authors: Lee
mesh_terms: D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics* / Q000378:metabolism; D016017:Odds Ratio; D010518:Periodontitis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D039781:PubMed; D051193:Toll-Like Receptors / Q000235:genetics* / Q000378:metabolism
chemical_list: D051193:Toll-Like Receptors; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1
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