title: The mechanism of cytostatic effect of a new somatostatin analog cifetrelin on in vitro cultured MCF-7 breast carcinoma cells.
abstract: The mechanisms of antitumor effect of cifetrelin have been studied in vitro on cultured MCF-7 breast carcinoma cells. Cifetrelin exhibits higher cytotoxic activity than native somatostatin. In subthreshold concentrations, cifetrelin boosts the apoptotic effects of drugs, e.g. adriamycin. Cifetrelin-induced apoptosis develops by the p53-independent mechanism and is associated with early suppression of NF-kappaB activity. These data attest to high antitumor activity of cifetrelin.
authors: N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences, Moscow, Russia. meldo@mail.ru
authors: E I
authors: EI
authors: Mikhaevich
authors: M A
authors: MA
authors: Krasil'nikov
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D054697:Cytostatic Agents / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D016328:NF-kappa B / Q000378:metabolism; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D054697:Cytostatic Agents; D016328:NF-kappa B; C586382:cifetrelin; D013004:Somatostatin; D004317:Doxorubicin