title: Molecular networks in melanoma invasion and metastasis.
abstract: Metastatic melanoma accounts for approximately 80% of skin cancer-related deaths. Up to now there has been no effective treatment for stage IV melanoma patients due to the complexity and dissemination potential of this disease. Melanomas are heterogeneous tumors in which conventional therapies fail to improve overall survival. Targeted therapies are being developed, but the final outcome can be hampered by the incomplete knowledge of the process of melanoma progression. Even if the intracellular pathways are similar, the interaction of the cells with the surrounding environment should be taken into consideration. This article seeks to highlight some of the advances in the understanding of the molecular mechanisms underlying melanoma dissemination.
authors: Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, Milan, Italy.
authors: Ewa
authors: E
authors: Aladowicz
authors: Leda
authors: L
authors: Ferro
authors: Giulio Cesare
authors: GC
authors: Vitali
authors: Elisabetta
authors: E
authors: Venditti
authors: Lorenzo
authors: L
authors: Fornasari
authors: Luisa
authors: L
authors: Lanfrancone
mesh_terms: D002448:Cell Adhesion / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D002465:Cell Movement / Q000235:genetics; D006801:Humans; D008545:Melanoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology*; D055765:Shc Signaling Adaptor Proteins / Q000235:genetics / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D015815:Cell Adhesion Molecules; C519335:SHC4 protein, human; D055765:Shc Signaling Adaptor Proteins