title: Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid.
abstract: Interleukin-22 (IL-22) is mainly produced at barrier surfaces by T cells and innate lymphoid cells and is crucial to maintain epithelial integrity. However, dysregulated IL-22 action leads to deleterious inflammation and is involved in diseases such as psoriasis, intestinal inflammation, and cancer. IL-22 binding protein (IL-22BP) is a soluble inhibitory IL-22 receptor and may represent a crucial regulator of IL-22. We show both in rats and mice that, in the steady state, the main source of IL-22BP is constituted by a subset of conventional dendritic cells (DCs) in lymphoid and non-lymphoid tissues. In mouse intestine, IL-22BP was specifically expressed in lamina propria CD103(+)CD11b(+) DC. In humans, IL-22BP was expressed in immature monocyte-derived DC and strongly induced by retinoic acid but dramatically reduced upon maturation. Our data suggest that a subset of immature DCs may actively participate in the regulation of IL-22 activity in the gut by producing high levels of IL-22BP.
authors: 1] INSERM Center of Research in Transplantation and Immunology, UMR1064, Nantes, France [2] CHU Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France [3] CHU Nantes, Laboratoire d'immunologie, Nantes, France [4] Faculté de Médecine, Université de Nantes, Nantes, France.
authors: J C J
authors: JC
authors: Martin
authors: 1] INSERM Center of Research in Transplantation and Immunology, UMR1064, Nantes, France [2] CHU Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France.
authors: G
authors: G
authors: Bériou
authors: 1] INSERM Center of Research in Transplantation and Immunology, UMR1064, Nantes, France [2] CHU Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France.
authors: M
authors: M
authors: Heslan
authors: 1] INSERM Center of Research in Transplantation and Immunology, UMR1064, Nantes, France [2] CHU Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France.
authors: C
authors: C
authors: Chauvin
authors: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
authors: L
authors: L
authors: Utriainen
authors: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
authors: A
authors: A
authors: Aumeunier
authors: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
authors: C L
authors: CL
authors: Scott
authors: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
authors: A
authors: A
authors: Mowat
authors: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
authors: V
authors: V
authors: Cerovic
authors: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
authors: S A
authors: SA
authors: Houston
authors: Department of Gene and Cell medicine and the Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.
authors: M
authors: M
authors: Leboeuf
authors: 1] INSERM Center of Research in Transplantation and Immunology, UMR1064, Nantes, France [2] CHU Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France [3] Faculté de Médecine, Université de Nantes, Nantes, France.
authors: F X
authors: FX
authors: Hubert
authors: 1] INSERM Center of Research in Transplantation and Immunology, UMR1064, Nantes, France [2] CHU Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France [3] CHU Nantes, Laboratoire d'immunologie, Nantes, France [4] Faculté de Médecine, Université de Nantes, Nantes, France.
authors: C
authors: C
authors: Hémont
authors: Department of Gene and Cell medicine and the Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.
authors: M
authors: M
authors: Merad
authors: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
authors: S
authors: S
authors: Milling
authors: 1] INSERM Center of Research in Transplantation and Immunology, UMR1064, Nantes, France [2] CHU Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France [3] CHU Nantes, Laboratoire d'immunologie, Nantes, France [4] Faculté de Médecine, Université de Nantes, Nantes, France.
authors: R
authors: R
authors: Josien
mesh_terms: D000818:Animals; D015704:CD4 Antigens / Q000378:metabolism; D002454:Cell Differentiation / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D009928:Organ Specificity / Q000235:genetics; D020033:Protein Isoforms; D051381:Rats; D018123:Receptors, Interleukin / Q000235:genetics* / Q000378:metabolism; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D015704:CD4 Antigens; D020033:Protein Isoforms; D018123:Receptors, Interleukin; C415369:interleukin-22 receptor; D014212:Tretinoin
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