title: Neural circuits and motivational processes for hunger.
abstract: How does an organism's internal state direct its actions? At one moment an animal forages for food with acrobatic feats such as tree climbing and jumping between branches. At another time, it travels along the ground to find water or a mate, exposing itself to predators along the way. These behaviors are costly in terms of energy or physical risk, and the likelihood of performing one set of actions relative to another is strongly modulated by internal state. For example, an animal in energy deficit searches for food and a dehydrated animal looks for water. The crosstalk between physiological state and motivational processes influences behavioral intensity and intent, but the underlying neural circuits are poorly understood. Molecular genetics along with optogenetic and pharmacogenetic tools for perturbing neuron function have enabled cell type-selective dissection of circuits that mediate behavioral responses to physiological state changes. Here, we review recent progress into neural circuit analysis of hunger in the mouse by focusing on a starvation-sensitive neuron population in the hypothalamus that is sufficient to promote voracious eating. We also consider research into the motivational processes that are thought to underlie hunger in order to outline considerations for bridging the gap between homeostatic and motivational neural circuits.
authors: Janelia Farm Research Campus, Ashburn, VA 20147, USA. sternsons@janelia.hhmi.org
authors: Scott M
authors: SM
authors: Sternson
authors: J
authors: J
authors: Nicholas Betley
authors: Zhen Fang Huang
authors: ZF
authors: Cao
mesh_terms: D000818:Animals; D001519:Behavior / Q000502:physiology*; D004435:Eating / Q000502:physiology / Q000523:psychology; D006801:Humans; D006815:Hunger / Q000502:physiology*; D051379:Mice; D009042:Motivation / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology*
references: Behav Neurosci. 2003 Apr;117(2):202-11
references: 12708516
references: Nat Neurosci. 2011 Nov 13;14(12):1562-8
references: 22081158
references: Science. 1962 Feb 2;135(3501):374-5
references: 14469788
references: Int J Obes (Lond). 2006 Feb;30(2):293-6
references: 16247504
references: Diabetes. 2007 May;56(5):1219-27
references: 17261674
references: Psychopharmacology (Berl). 1996 May;125(2):105-12
references: 8783383
references: Eur J Pharmacol. 1999 May 21;372(3):237-40
references: 10395017
references: Physiol Behav. 1990 May;47(5):881-8
references: 2388944
references: Psychopharmacology (Berl). 1982;77(4):379-82
references: 6813901
references: Nat Neurosci. 2012 Jun 24;15(8):1108-10
references: 22729177
references: Addict Biol. 2006 Mar;11(1):45-54
references: 16759336
references: Am J Physiol Regul Integr Comp Physiol. 2012 Aug 1;303(3):R259-69
references: 22673784
references: Addict Biol. 2007 Mar;12(1):6-16
references: 17407492
references: Pharmacol Biochem Behav. 2001 Apr;68(4):709-20
references: 11526968
references: Physiol Behav. 1981 Jul;27(1):137-42
references: 7267792
references: Cell. 2011 Apr 1;145(1):133-44
references: 21458672
references: Science. 1962 Feb 2;135(3501):375-7
references: 13907995
references: Neuron. 2003 Feb 20;37(4):649-61
references: 12597862
references: Science. 1950 Sep 1;112(2905):256-9
references: 15442325
references: Physiol Behav. 2005 Feb 15;84(2):217-31
references: 15708774
references: Physiol Behav. 1988;42(6):517-28
references: 3166142
references: Science. 2005 Oct 28;310(5748):683-5
references: 16254186
references: Nat Neurosci. 2011 Mar;14(3):351-5
references: 21209617
references: Neurosci Biobehav Rev. 2000 Mar;24(2):173-98
references: 10714382
references: Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15043-8
references: 9844012
references: PLoS One. 2011;6(11):e27180
references: 22076135
references: Proc Natl Acad Sci U S A. 2009 May 5;106(18):7281-8
references: 19342487
references: Physiol Behav. 2006 Nov 30;89(4):611-6
references: 17045623
references: Nat Neurosci. 2010 May;13(5):615-21
references: 20364145
references: Science. 1971 Sep 17;173(4002):1103-7
references: 5098954
references: Curr Opin Neurobiol. 2013 Feb;23(1):68-75
references: 22939570
references: Am J Physiol. 1953 Jan;172(1):162-8
references: 13030733
references: J Clin Invest. 2006 Dec;116(12):3229-39
references: 17060947
references: Eur J Neurosci. 1989 Jan;1(1):53-60
references: 12106174
references: Science. 1961 Sep 29;134(3483):943-4
references: 13714876
references: Eur J Neurosci. 2006 May;23(10):2677-85
references: 16817870
references: Appetite. 2007 Mar;48(2):139-44
references: 17034902
references: Cell. 2012 Feb 3;148(3):583-95
references: 22304923
references: Neuron. 2006 Sep 21;51(6):811-22
references: 16982425
references: Neuropsychopharmacology. 2006 Jul;31(7):1362-70
references: 16319913
references: Nat Neurosci. 2004 May;7(5):493-4
references: 15097991
references: Physiol Behav. 2009 Jun 22;97(3-4):406-13
references: 19303888
references: Nature. 2012 Aug 9;488(7410):172-7
references: 22801496
references: Brain Res. 1985 Nov 11;347(1):85-93
references: 4052808
references: J Neurophysiol. 2009 Jun;101(6):2898-906
references: 19297511
references: Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11044-9
references: 10995460
references: Appetite. 2006 Jan;46(1):63-6
references: 16298017
references: Ann N Y Acad Sci. 1992 Jun 28;654:171-91
references: 1632582
references: Physiol Behav. 1983 Feb;30(2):185-92
references: 6844432
references: Physiol Behav. 2001 May;73(1-2):229-34
references: 11399316
references: J Exp Psychol Anim Behav Process. 2006 Oct;32(4):460-6
references: 17044748
references: J Comp Physiol Psychol. 1957 Oct;50(5):486-90
references: 13481188
references: Physiol Behav. 2004 Apr;81(2):179-209
references: 15159167
references: Nat Neurosci. 2007 May;10(5):663-8
references: 17435752
references: Science. 1997 Oct 3;278(5335):135-8
references: 9311920
references: Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20709-13
references: 23184995
references: J Clin Invest. 2011 Apr;121(4):1424-8
references: 21364278
references: Neurosci Biobehav Rev. 2002 Oct;26(6):713-28
references: 12479844
references: Neuron. 2013 Mar 6;77(5):810-24
references: 23473313
references: Pharmacol Biochem Behav. 1988 Aug;30(4):889-93
references: 3227037
references: Am J Physiol. 1988 Oct;255(4 Pt 2):R672-5
references: 3140680
references: Physiol Behav. 1988;42(3):223-9
references: 3406148
references: Nature. 1974 Feb 1;247(5439):284-6
references: 4818362
references: Appetite. 1991 Apr;16(2):103-20
references: 2064389
references: BMC Neurosci. 2004 Feb 23;5:5
references: 15028115
references: Physiol Behav. 1997 Mar;61(3):461-73
references: 9089767
references: Neuron. 2006 Sep 21;51(6):801-10
references: 16982424
references: Results Probl Cell Differ. 2010;52:115-37
references: 20865376
references: Neuron. 2008 Mar 27;57(6):930-41
references: 18367093