title: The comprehensive antibiotic resistance database.
abstract: The field of antibiotic drug discovery and the monitoring of new antibiotic resistance elements have yet to fully exploit the power of the genome revolution. Despite the fact that the first genomes sequenced of free living organisms were those of bacteria, there have been few specialized bioinformatic tools developed to mine the growing amount of genomic data associated with pathogens. In particular, there are few tools to study the genetics and genomics of antibiotic resistance and how it impacts bacterial populations, ecology, and the clinic. We have initiated development of such tools in the form of the Comprehensive Antibiotic Research Database (CARD; http://arpcard.mcmaster.ca). The CARD integrates disparate molecular and sequence data, provides a unique organizing principle in the form of the Antibiotic Resistance Ontology (ARO), and can quickly identify putative antibiotic resistance genes in new unannotated genome sequences. This unique platform provides an informatic tool that bridges antibiotic resistance concerns in health care, agriculture, and the environment.
authors: M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
authors: Andrew G
authors: AG
authors: McArthur
authors: Nicholas
authors: N
authors: Waglechner
authors: Fazmin
authors: F
authors: Nizam
authors: Austin
authors: A
authors: Yan
authors: Marisa A
authors: MA
authors: Azad
authors: Alison J
authors: AJ
authors: Baylay
authors: Kirandeep
authors: K
authors: Bhullar
authors: Marc J
authors: MJ
authors: Canova
authors: Gianfranco
authors: G
authors: De Pascale
authors: Linda
authors: L
authors: Ejim
authors: Lindsay
authors: L
authors: Kalan
authors: Andrew M
authors: AM
authors: King
authors: Kalinka
authors: K
authors: Koteva
authors: Mariya
authors: M
authors: Morar
authors: Michael R
authors: MR
authors: Mulvey
authors: Jonathan S
authors: JS
authors: O'Brien
authors: Andrew C
authors: AC
authors: Pawlowski
authors: Laura J V
authors: LJ
authors: Piddock
authors: Peter
authors: P
authors: Spanogiannopoulos
authors: Arlene D
authors: AD
authors: Sutherland
authors: Irene
authors: I
authors: Tang
authors: Patricia L
authors: PL
authors: Taylor
authors: Maulik
authors: M
authors: Thaker
authors: Wenliang
authors: W
authors: Wang
authors: Marie
authors: M
authors: Yan
authors: Tennison
authors: T
authors: Yu
authors: Gerard D
authors: GD
authors: Wright
mesh_terms: D000890:Anti-Infective Agents; D001483:Base Sequence; D019295:Computational Biology; D030541:Databases, Genetic; D004352:Drug Resistance, Microbial / Q000235:genetics*; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D020407:Internet; D014584:User-Computer Interface
chemical_list: D000890:Anti-Infective Agents
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