title: Prevalence of and factors associated with sarcopenia in elderly patients with end-stage renal disease.
abstract: OBJECTIVE
  We investigated the prevalence of sarcopenia in elderly patients with end-stage renal disease (ESRD) and its relationship with various markers of nutrition, cognitive function, depressive symptoms, inflammation and β2-microglobulin.
  
  
  METHODS
  A cross-sectional study was conducted with 95 patients having ESRD aged over 50 years. Sarcopenia was defined as a decline in both muscle mass and strength.
  
  
  RESULTS
  The mean age was 63.9 ± 10.0 years; 56.8% were men and 52.6% had diabetes. Sarcopenia was highly prevalent in elderly patients with ESRD (37.0% in men and 29.3% in women). Subjective Global Assessment (SGA), inflammatory markers and β2-microglobulin levels were significantly associated with sarcopenia, even after adjustment for age, gender, diabetes, and body mass index. Additionally, patients with depressive symptoms showed a higher risk of sarcopenia relative to those without depressive symptoms (odds ratio, OR = 6.87, 95% confidence interval, CI = 2.06-22.96) and sarcopenia was more likely to be present in patients with mild cognitive dysfunction (OR = 6.35, 95% CI = 1.62-34.96).
  
  
  CONCLUSIONS
  Sarcopenia is highly prevalent in elderly patients with ESRD and is closely associated with SGA, inflammatory markers, β2-microglobulin, depression and cognitive dysfunction.
authors: Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea.
authors: Jwa-Kyung
authors: JK
authors: Kim
authors: Department of Internal Medicine, Kangnam Sacred Heart Hospital, Seoul, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea.
authors: Sun Ryoung
authors: SR
authors: Choi
authors: Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Seoul, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea.
authors: Myung Jin
authors: MJ
authors: Choi
authors: Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea.
authors: Sung Gyun
authors: SG
authors: Kim
authors: Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Seoul, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea.
authors: Young Ki
authors: YK
authors: Lee
authors: Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Seoul, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea.
authors: Jung Woo
authors: JW
authors: Noh
authors: Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea.
authors: Hyung Jik
authors: HJ
authors: Kim
authors: Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea. Electronic address: yrisong@hanmail.net.
authors: Young Rim
authors: YR
authors: Song
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D015992:Body Mass Index; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000150:complications / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D003863:Depression / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000378:metabolism; D009752:Nutritional Status; D015995:Prevalence; D012307:Risk Factors; D055948:Sarcopenia / Q000150:complications / Q000453:epidemiology*; D001613:beta 2-Microglobulin / Q000097:blood
chemical_list: D015415:Biomarkers; D001613:beta 2-Microglobulin
keywords: Depression; End-stage renal disease; Inflammation; Sarcopenia; β2-microglobulin