title: Localized Statistics for DW-MRI Fiber Bundle Segmentation.
abstract: We describe a method for segmenting neural fiber bundles in diffusion-weighted magnetic resonance images (DWMRI). As these bundles traverse the brain to connect regions, their local orientation of diffusion changes drastically, hence a constant global model is inaccurate. We propose a method to compute localized statistics on orientation information and use it to drive a variational active contour segmentation that accurately models the non-homogeneous orientation information present along the bundle. Initialized from a single fiber path, the proposed method proceeds to capture the entire bundle. We demonstrate results using the technique to segment the cingulum bundle and describe several extensions making the technique applicable to a wide range of tissues.
authors: Georgia Institute of Techology Atlanta, GA, USA 30322.
authors: Shawn
authors: S
authors: Lankton
authors: John
authors: J
authors: Melonakos
authors: James
authors: J
authors: Malcolm
authors: Samuel
authors: S
authors: Dambreville
authors: Allen
authors: A
authors: Tannenbaum
references: Med Image Anal. 2005 Oct;9(5):427-40
references: 16040268
references: Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10422-7
references: 10468624
references: Med Image Comput Comput Assist Interv. 2005;8(Pt 1):180-7
references: 16685844
references: IEEE Trans Image Process. 2001;10(2):266-77
references: 18249617
references: Magn Reson Med. 2006 Aug;56(2):411-21
references: 16788917
references: Proc IEEE Comput Soc Conf Comput Vis Pattern Recognit. 2008;:1-8
references: 23680693
references: Inf Process Med Imaging. 2005;19:591-602
references: 17354728
references: IEEE Trans Pattern Anal Mach Intell. 2008 Mar;30(3):412-23
references: 18195436
references: IEEE Trans Image Process. 2007 Nov;16(11):2787-801
references: 17990755
references: Am J Psychiatry. 2004 Mar;161(3):573-5
references: 14992988
references: Med Image Anal. 2005 Jun;9(3):223-36
references: 15854843
references: IEEE Trans Med Imaging. 2006 Aug;25(8):965-78
references: 16894991
references: Neuroimage. 2001 Sep;14(3):723-35
references: 11506544
references: Med Image Comput Comput Assist Interv. 2007;10(Pt 2):495-502
references: 18044605
references: IEEE Trans Med Imaging. 2002 May;21(5):505-12
references: 12071621
references: Inf Process Med Imaging. 2007;20:346-58
references: 17633712
references: J Magn Reson B. 1996 Jun;111(3):209-19
references: 8661285
references: NMR Biomed. 2002 Nov-Dec;15(7-8):468-80
references: 12489096
references: Biol Psychiatry. 2003 Dec 1;54(11):1171-80
references: 14643084
references: IEEE Trans Med Imaging. 2006 Jun;25(6):685-700
references: 16768234
references: Magn Reson Med. 2000 Oct;44(4):625-32
references: 11025519
references: Proc IEEE Int Conf Comput Vis. 2007;:1-8
references: 23857521
references: Inf Process Med Imaging. 2005;19:52-63
references: 17354684
references: Med Image Comput Comput Assist Interv. 2007;10(Pt 1):36-43
references: 18051041
references: IEEE Trans Med Imaging. 2007 Nov;26(11):1525-36
references: 18041267
references: J Magn Reson Imaging. 2003 Aug;18(2):242-54
references: 12884338
references: Ann Neurol. 1999 Feb;45(2):265-9
references: 9989633