title: Scab-inspired cytophilic membrane of anisotropic nanofibers for rapid wound healing.
abstract: This work investigates the influence of cytophilic and anisotropic nanomaterials on accelerated cell attachment and directional migration toward rapid wound healing. Inspired by the anisotropic protein nanofibers in scab, a polyurethane (PU) nanofibrous membrane with an aligned structure was fabricated. The membrane showed good affinity for wound-healing-related cells and could guide cell migration in the direction of PU nanofibers. Also, the morphology and distribution of F-actin and paxillin of attached cells were influenced by the underlying nanofibers. The randomly distributed PU nanofibers and planar PU membrane did not show a distinct impact on cell migration. This scab-inspired cytophilic membrane is promising in applications as functional interfacial biomaterials for rapid wound healing, bone repair, and construction of neural networks.
authors: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors: Yanli
authors: Y
authors: Xi
authors: Hua
authors: H
authors: Dong
authors: Kang
authors: K
authors: Sun
authors: Hongliang
authors: H
authors: Liu
authors: Ruiming
authors: R
authors: Liu
authors: Yuansen
authors: Y
authors: Qin
authors: Zuojun
authors: Z
authors: Hu
authors: Yong
authors: Y
authors: Zhao
authors: Fuqiang
authors: F
authors: Nie
authors: Shutao
authors: S
authors: Wang
mesh_terms: D000818:Animals; D016880:Anisotropy; D001458:Bandages; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D002465:Cell Movement / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology / Q000648:ultrastructure; D006097:Granulation Tissue / Q000378:metabolism* / Q000648:ultrastructure; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007908:Lens, Crystalline / Q000166:cytology; D051379:Mice; D008855:Microscopy, Electron, Scanning; D041681:NIH 3T3 Cells; D057139:Nanofibers / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D012867:Skin / Q000166:cytology / Q000293:injuries*; D014945:Wound Healing / Q000502:physiology*