title: Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?
abstract: Vitamin B12 is an essential micronutrient required for optimal hemopoetic, neuro-cognitive and cardiovascular function. Biochemical and clinical vitamin B12 deficiency has been demonstrated to be highly prevalent among patients with type 1 and type 2 diabetes mellitus. It presents with diverse clinical manifestations ranging from impaired memory, dementia, delirium, peripheral neuropathy, sub acute combined degeneration of the spinal cord, megaloblastic anemia and pancytopenia. This review article offers a current perspective on the physiological roles of vitamin B12, proposed pathophysiological mechanisms of vitamin B12 deficiency, screening for vitamin B12 deficiency and vitamin B12 supplementation among patients with diabetes mellitus.
authors: Department of Medicine, St, Raphael of St, Francis hospital Nsambya, P,O,BOX 7146, Kampala, Uganda. davouirek@yahoo.co.uk.
authors: Davis
authors: D
authors: Kibirige
authors: Raymond
authors: R
authors: Mwebaze
references: Am J Clin Nutr. 2009 Feb;89(2):702S-6S
references: 19141696
references: Lancet. 2004 Mar 6;363(9411):793-803
references: 15016491
references: J Clin Endocrinol Metab. 2008 Feb;93(2):363-71
references: 18029461
references: J Assoc Physicians India. 2012 Mar;60:58-60
references: 22799121
references: Age Ageing. 2007 Mar;36(2):177-83
references: 17189285
references: J Clin Endocrinol Metab. 2006 Apr;91(4):1210-7
references: 16403820
references: Arch Intern Med. 2002 Oct 28;162(19):2251-2
references: 12390080
references: Indian J Med Res. 2011 Oct;134:432-9
references: 22089603
references: Am Fam Physician. 2003 Mar 1;67(5):979-86
references: 12643357
references: Diabetes. 1982 Dec;31(12):1051-5
references: 7173496
references: CMAJ. 2004 Aug 3;171(3):251-9
references: 15289425
references: Arch Intern Med. 1999 Jun 28;159(12):1289-98
references: 10386505
references: Diabetes Care. 2000 Sep;23(9):1227-31
references: 10977010
references: Age Ageing. 2006 Mar;35(2):200-1
references: 16495296
references: BMJ. 2010 May 20;340:c2181
references: 20488910
references: Arch Intern Med. 2006 Oct 9;166(18):1975-9
references: 17030830
references: Neth J Med. 2009 Dec;67(11):376-87
references: 20009114
references: Int J Food Sci Nutr. 2009;60 Suppl 5:71-6
references: 19212856
references: J Young Pharm. 2010 Oct;2(4):428-9
references: 21264109
references: Diabetes Care. 2010 Jan;33(1):156-61
references: 19846797
references: Rev Assoc Med Bras (1992). 2011 Jan-Feb;57(1):46-9
references: 21390459
references: J Clin Endocrinol Metab. 1999 Nov;84(11):4062-7
references: 10566650
references: Diabet Med. 2000 Aug;17(8):618-22
references: 11073185
references: Diabetes Res Clin Pract. 2012 Sep;97(3):359-67
references: 22770998
references: Endocr Pract. 2012 Mar-Apr;18(2):179-84
references: 21940283
references: Cochrane Database Syst Rev. 2003;(3):CD004326
references: 12918012
references: N Engl J Med. 2004 May 13;350(20):2068-79
references: 15141045
references: Diabetes Care. 2012 Feb;35(2):327-33
references: 22179958
references: Clin Chem. 2000 Aug;46(8 Pt 2):1277-83
references: 10926922
references: J Am Board Fam Med. 2009 Sep-Oct;22(5):528-34
references: 19734399
references: BMC Cardiovasc Disord. 2006 Sep 26;6:38
references: 17002799
references: Clin Med Res. 2006 Sep;4(3):236-41
references: 16988104
references: Fam Pract. 2006 Jun;23(3):279-85
references: 16585128
references: J Intern Med. 2003 Nov;254(5):455-63
references: 14535967
references: Haematologica. 2006 Nov;91(11):1506-12
references: 17043022
references: Food Nutr Bull. 2008 Jun;29(2 Suppl):S116-25
references: 18709886
references: J Neurol Neurosurg Psychiatry. 2000 Aug;69(2):228-32
references: 10896698
references: South Med J. 2010 Mar;103(3):265-7
references: 20134380
references: J Blood Med. 2012;3:97-103
references: 23028239
references: Endocrinol Metab Clin North Am. 2004 Mar;33(1):197-214, xi
references: 15053903
references: Thromb J. 2009 May 13;7:5
references: 19439095
references: J Assoc Physicians India. 2006 Oct;54:775-82
references: 17214273
references: Med Clin North Am. 1975 Sep;59(5):1133-45
references: 1099360
references: J Clin Gastroenterol. 2010 Jan;44(1):4-8
references: 20027009
references: N Engl J Med. 1995 Aug 31;333(9):541-9
references: 7623902
references: Acta Neurol Taiwan. 2005 Jun;14(2):48-54
references: 16008162
references: Diabetes Care. 2012 Jan;35 Suppl 1:S11-63
references: 22187469
references: Indian J Endocrinol Metab. 2012 Mar;16 Suppl 1:S79-82
references: 22701852