title: [Seroprevalence of infectious markers among blood donors in Niamey (Niger)].
abstract: BACKGROUND
  The study aimed to determine the seroprevalence of transfusion-transmitted infectious (TTI) markers for human immunodeficiency virus (HIV), hepatitis B and C viruses (HBV, HCV) and syphilis among blood donors in Niamey (Niger). The association between seroprevalence of ITT markers and sociodemographic characteristics of blood donors was investigated.
  
  
  METHODS
  A cross-sectional study was conducted in 2010 among 3213 blood donors. Data were collected from a pre-donation questionnaire and from laboratory tests results.
  
  
  RESULTS
  The male/female ratio was 4/1. Up to 18.1% of donations had at least one positive marker, in which 2.7% presented a positive test for two or more agents. A seroprevalence of 1.62% (95%CI: 1.21-2.12) was associated with HIV, 15.4% (13.9-16.7) with HBV, 1.18% (0.84-1.62) with HCV, and 0.47% (0.26-0.77) for blood samples reacted with RPR test for syphilis. The HIV seroprevalence was two-fold higher in family than in volunteer donors (OR=2.15, 95%CI: 1.24-3.73). It was also higher in Rhesus D negative donors (OR=2.40, 95%CI: 1.11-5.17). The hepatitis B surface antigen seroprevalence was significantly higher in males than females (OR=1.85, 95%CI: 1.39-2.45) and in first time than in regular donors (P<0.0001). The HCV seroprevalence was significantly higher in male donors (OR=4.41, 95%CI: 1.06-18.4) and in donors from rural areas (OR=4.09, 95%CI: 1.42-11.8). Syphilis marker was significantly associated with the marital status (higher seroprevalence in divorced donors, P=0.0085).
  
  
  CONCLUSIONS
  Prevalence of TTI markers is high and national strategies for safe blood transfusion have to be strengthened. It is essential to recruit and maintain more volunteer donors, while females should be encouraged to donate blood.
authors: Centre national de transfusion sanguine, BP 2399, Niamey, Niger. mzoubeida@yahoo.fr
authors: Z
authors: Z
authors: Mayaki
authors: N
authors: N
authors: Dardenne
authors: R
authors: R
authors: Kabo
authors: M
authors: M
authors: Moutschen
authors: D
authors: D
authors: Sondag
authors: A
authors: A
authors: Albert
authors: C
authors: C
authors: Gérard
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001782:Blood Donors / Q000706:statistics & numerical data*; D003141:Communicable Diseases / Q000097:blood / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009548:Niger / Q000453:epidemiology; D015995:Prevalence; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers