title: Chemical constituents from Nelumbo nucifera leaves and their anti-obesity effects.
abstract: Nelumbo nucifera Gaertn. (Nymphaeaceae), commonly called lotus, is widely distributed throughout Eastern Asia. It has been used for food and medicine for a long time. A phytochemical investigation of N. nucifera leaves led to the isolation of 13 megastigmanes (1-13), including a new megastigmane, nelumnucifoside A (1), and a new eudesmane sesquiterpene, nelumnucifoside B (14), eight alkaloids (15-22), and 11 flavonoids (23-33). Their chemical structures were determined based on spectroscopic methods including 1D, 2D NMR and MS spectrometry. The relative and absolute stereochemistry of the compounds was determined by NOESY and CD spectrometry, respectively. Compounds 19 and 22 significantly inhibited pancreatic lipase, whereas compounds 15 and 16 showed a strong inhibitory effect on adipocyte differentiation. Therefore, the leaves of N. nucifera have potential as an anti-obesity agent by inhibiting pancreatic lipase and adipocyte differentiation.
authors: College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
authors: Jong Hoon
authors: JH
authors: Ahn
authors: Eun Sil
authors: ES
authors: Kim
authors: Chul
authors: C
authors: Lee
authors: Soonok
authors: S
authors: Kim
authors: Soo-Hyun
authors: SH
authors: Cho
authors: Bang Yeon
authors: BY
authors: Hwang
authors: Mi Kyeong
authors: MK
authors: Lee
mesh_terms: D019440:Anti-Obesity Agents / Q000737:chemistry* / Q000494:pharmacology*; D031653:Nelumbo / Q000737:chemistry*; D009765:Obesity / Q000188:drug therapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D019440:Anti-Obesity Agents; D010936:Plant Extracts