title: Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes.
abstract: Previous studies show that children who later progress to type 1 diabetes (T1D) have decreased preautoimmune concentrations of multiple phospholipids as compared with nonprogressors. It is still unclear whether these changes associate with development of β-cell autoimmunity or specifically with clinical T1D. Here, we studied umbilical cord serum lipidome in infants who later developed T1D (N = 33); infants who developed three or four (N = 31) islet autoantibodies, two (N = 31) islet autoantibodies, or one (N = 48) islet autoantibody during the follow-up; and controls (N = 143) matched for sex, HLA-DQB1 genotype, city of birth, and period of birth. The analyses of serum molecular lipids were performed using the established lipidomics platform based on ultra-performance liquid chromatography coupled to mass spectrometry. We found that T1D progressors are characterized by a distinct cord blood lipidomic profile that includes reduced major choline-containing phospholipids, including sphingomyelins and phosphatidylcholines. A molecular signature was developed comprising seven lipids that predicted high risk for progression to T1D with an odds ratio of 5.94 (95% CI, 1.07-17.50). Reduction in choline-containing phospholipids in cord blood therefore is specifically associated with progression to T1D but not with development of β-cell autoimmunity in general.
authors: VTT Technical Research Centre of Finland, Espoo, Finland. matej.oresic@vtt.fi
authors: Matej
authors: M
authors: Oresic
authors: Peddinti
authors: P
authors: Gopalacharyulu
authors: Juha
authors: J
authors: Mykkänen
authors: Niina
authors: N
authors: Lietzen
authors: Marjaana
authors: M
authors: Mäkinen
authors: Heli
authors: H
authors: Nygren
authors: Satu
authors: S
authors: Simell
authors: Ville
authors: V
authors: Simell
authors: Heikki
authors: H
authors: Hyöty
authors: Riitta
authors: R
authors: Veijola
authors: Jorma
authors: J
authors: Ilonen
authors: Marko
authors: M
authors: Sysi-Aho
authors: Mikael
authors: M
authors: Knip
authors: Tuulia
authors: T
authors: Hyötyläinen
authors: Olli
authors: O
authors: Simell
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059866:HLA-DQ beta-Chains / Q000235:genetics; D006801:Humans; D007223:Infant; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D011446:Prospective Studies
chemical_list: D001323:Autoantibodies; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D010743:Phospholipids
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