title: [Expression of the RT1A molecule of the class I major histocompatibility complex in a Walker 256 tumor after transplantation into Brattleboro rats with a genetic defect of arginine-vasopressin synthesis].
abstract: The dynamics of expression of the RT1A antigen of the class I major histocompatibility complex (MHC) in a Walker 256 tumor after its transplantation into Brattleboro rats with a genetic defect of Arginine-Vasopressin synthesis in the hypothalamus was studied. Expression of the RT1A antigen was detected by means of Western-blotting and flow cytometry in the tumor cells on the 14th-17th days after transplantation. In addition, a simultaneous increase in the portion of cells that express the RT1A antigen and in the level of its expression per cell was observed. It is presupposed that at a deficiency of Arginine-Vasopressin, a renewal of expression of the class I MHC antigens, which results in an increase of immunogenicity of this tumor and regression, occurs in the Walker 256 tumor in the Brattleboro rats.
authors: V I
authors: VI
authors: Mel'nikova
authors: I I
authors: II
authors: Khegaĭ
authors: M A
authors: MA
authors: Afanas'eva
authors: L N
authors: LN
authors: Ivanova
authors: L A
authors: LA
authors: Zakharova
mesh_terms: D000818:Animals; D001120:Arginine / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D002279:Carcinoma 256, Walker / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D005434:Flow Cytometry; D006649:Histocompatibility Antigens / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D011910:Rats, Brattleboro; D014667:Vasopressins / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism
chemical_list: D006649:Histocompatibility Antigens; D015395:Histocompatibility Antigens Class I; C038353:histocompatibility antigens RT, rat; D014667:Vasopressins; D001120:Arginine