title: Neuropsychological indicators of preclinical Alzheimer's disease among depressed older adults.
abstract: Older adults with major depressive disorder (MDD) may also have preclinical Alzheimer's disease (AD). Differential diagnosis is quite challenging due to the overlapping symptoms of MDD and AD. In the current study, we predicted that impaired long-term memory (an area most affected in early AD), but not executive function (an area affected in MDD and AD), would distinguish older depressed patients who developed AD from those who did not. Patients (N = 120) assessed as having MDD but not dementia at baseline were administered tests of cognitive function and followed longitudinally for subsequent diagnosis of AD. Using structural equation modeling we found a latent construct of long-term memory to be associated with AD to a greater extent than executive functioning. Additional analyses to enhance clinical utility of findings indicated that individual tests of episodic memory were most predictive of AD status. Tests of long-term memory can be utilized by the clinician when assessing for preclinical AD among depressed elderly.
authors: a Department of Psychology , Florida State University , Tallahassee , FL , USA.
authors: Nicole C
authors: NC
authors: Rushing
authors: Natalie
authors: N
authors: Sachs-Ericsson
authors: David C
authors: DC
authors: Steffens
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis*; D001288:Attention; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D003863:Depression / Q000150:complications*; D018450:Disease Progression; D056344:Executive Function; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D008960:Models, Psychological; D009483:Neuropsychological Tests; D009949:Orientation; D011237:Predictive Value of Tests
references: Neuropsychology. 2005 Jul;19(4):520-31
references: 16060827
references: Neurology. 2005 Jun 14;64(11):1853-9
references: 15955933
references: J Neuropsychiatry Clin Neurosci. 2006 Winter;18(1):117-20
references: 16525080
references: Eur Arch Psychiatry Clin Neurosci. 2000;250(4):186-93
references: 11009071
references: Acta Neurol Scand Suppl. 2003;179:34-41
references: 12603249
references: Neuroimage. 2006 Nov 15;33(3):969-79
references: 17010646
references: Acta Psychiatr Scand. 2009 Apr;119(4):252-65
references: 19236314
references: Am J Geriatr Psychiatry. 2005 Nov;13(11):968-75
references: 16286440
references: J Psychiatr Res. 2003 Mar-Apr;37(2):99-108
references: 12842163
references: Am J Psychiatry. 1993 Nov;150(11):1693-9
references: 8105707
references: J Int Neuropsychol Soc. 2006 Sep;12(5):707-35
references: 16961952
references: Int Psychogeriatr. 2005 Jun;17(2):289-301
references: 16050437
references: Ann Neurol. 2008 Nov;64(5):492-8
references: 19067364
references: J Psychiatr Res. 1975 Nov;12(3):189-98
references: 1202204
references: Br J Psychiatry. 2001 Mar;178:200-6
references: 11230029
references: J Am Geriatr Soc. 2000 May;48(5):479-84
references: 10811539
references: Arch Neurol. 1994 Dec;51(12):1198-204
references: 7986174
references: Neurology. 1989 Sep;39(9):1159-65
references: 2771064
references: Am J Psychiatry. 2000 Jan;157(1):89-95
references: 10618018
references: Arch Gen Psychiatry. 1985 Jul;42(7):657-66
references: 4015307
references: Neurology. 1996 Mar;46(3):661-5
references: 8618663
references: Am J Psychiatry. 1994 Jul;151(7):957-70
references: 8010381
references: Eur J Neurol. 2005 Oct;12 Suppl 3:11-6
references: 16144532
references: Neuropsychopharmacology. 2008 Oct;33(11):2566-72
references: 18075490
references: Am J Psychiatry. 2000 Dec;157(12):1949-54
references: 11097959
references: J Geriatr Psychiatry Neurol. 2004 Dec;17(4):202-11
references: 15533991
references: Am J Geriatr Psychiatry. 2007 Oct;15(10):839-49
references: 17623814
references: Stroke. 2007 Dec;38(12):3182-5
references: 17962598
references: J Int Neuropsychol Soc. 1997 Nov;3(6):631-51
references: 9448376
references: J Neurol Neurosurg Psychiatry. 2007 Jun;78(6):638-40
references: 17210630
references: Neurology. 1993 Feb;43(2):250-60
references: 8094895
references: Acta Neuropathol. 2000 Aug;100(2):189-95
references: 10963367
references: Int J Geriatr Psychiatry. 2006 Oct;21(10):911-6
references: 16927401
references: Int J Geriatr Psychiatry. 2003 Feb;18(2):123-30
references: 12571820
references: Psychol Aging. 2009 Jun;24(2):373-84
references: 19485655
references: Arch Neurol. 1999 Oct;56(10):1233-9
references: 10520939
references: Int Psychogeriatr. 2007 Feb;19(1):125-35
references: 16834811
references: Aust N Z J Psychiatry. 2001 Dec;35(6):776-81
references: 11990888
references: Neurobiol Aging. 2008 Jan;29(1):31-8
references: 17097769
references: Psychiatry Res. 1992 Nov;44(2):93-106
references: 1480682
references: J Neuropsychiatry Clin Neurosci. 2007 Fall;19(4):373-82
references: 18070839
references: Neuropsychopharmacology. 2004 Dec;29(12):2266-71
references: 15340392
references: Br J Psychiatry. 1999 Sep;175:252-8
references: 10645327
references: Brain. 2001 Jan;124(Pt 1):96-102
references: 11133790
references: Neurology. 1984 Jul;34(7):939-44
references: 6610841
references: Int J Geriatr Psychiatry. 2008 Mar;23(3):257-65
references: 17668419
references: Neuropsychol Rev. 2008 Mar;18(1):73-90
references: 18347989
references: Arch Neurol. 2000 Jun;57(6):839-44
references: 10867781
references: Arch Neurol. 2001 Dec;58(12):1985-92
references: 11735772
references: Brain. 2000 Apr;123 ( Pt 4):770-80
references: 10734008
references: BMJ. 1995 Apr 15;310(6985):970-3
references: 7728032
references: Psychol Bull. 1973 Jun;79(6):380-5
references: 4707457
references: Neurology. 1997 Jan;48(1):132-8
references: 9008508
references: Arch Gen Psychiatry. 1981 Apr;38(4):381-9
references: 6260053
references: Endocr Rev. 1986 Aug;7(3):284-301
references: 3527687
references: J Neurol Neurosurg Psychiatry. 2008 Dec;79(12):1386-91
references: 19010949