title: Adaptive transfer of B10 cells: a novel therapy for chronic rejection after solid organ transplantation.
abstract: Chronic rejection occurs between almost all MHC-mismatched donors and recipients after transplantation. Immunosuppressive agents have been administrated indiscriminately to manage potential rejection, but complications from lifelong immunosuppressive therapy threaten transplant recipients. Recent studies demonstrated that a number of regulatory B cells (B10 cells) negatively regulate T cell mediated immune responses without inducing systemic immune suppression. Therefore, we propose that adaptive transfer of B10 cells suppresses alloreactive CD8(+) cytotoxic T cell activation induced by allogeneic solid organ transplantation, reduces T cell mediated rejection and prolongs allograft survival.
authors: Surgical Department of Peking University Third Hospital, China.
authors: Y
authors: Y
authors: Bao
authors: D R
authors: DR
authors: Xiu
mesh_terms: D019264:Adoptive Transfer; D001402:B-Lymphocytes / Q000166:cytology*; D002908:Chronic Disease; D006084:Graft Rejection; D006801:Humans; D016377:Organ Transplantation