title: Restorative strategies for the dopaminergic nigrostriatal projection pathway.
abstract: New insights into the mechanism of dopaminergic (DA) nigrostriatal neuron degeneration and regeneration in experimental studies in animal models of Parkinson's disease (PD) have opened up the discussion about novel therapeutic strategies such as cell-based therapies and neuroprotection of DA neurons. These cellular and molecular approaches aim at preventing or slowing down the progressive degeneration of DA neurons and/or replacing the lost ones. Here, a brief overview of basic principles and current strategies of these novel restorative approaches is discussed in light of experimental results and possible clinical applications.
authors: Division of Stereotactic and Functional Neurosurgery, Department of General Neurosurgery, Neurosurgical Clinic, University Medical Center Freiburg, Breisacher Straße 64, Freiburg, D-79106, Germany, guido.nikkhah@uk-erlangen.de.
authors: Guido
authors: G
authors: Nikkhah
mesh_terms: D000818:Animals; D016380:Brain Tissue Transplantation / Q000379:methods*; D003342:Corpus Striatum / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D059290:Dopaminergic Neurons / Q000502:physiology*; D006801:Humans; D009410:Nerve Degeneration / Q000209:etiology / Q000628:therapy*; D009434:Neural Pathways / Q000502:physiology; D018696:Neuroprotective Agents / Q000627:therapeutic use; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy; D013378:Substantia Nigra / Q000378:metabolism / Q000473:pathology*
chemical_list: D018696:Neuroprotective Agents