title: Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation.
abstract: A swept-source dual-wavelength photothermal (DWP) optical coherence tomography (OCT) system is demonstrated for quantitative imaging of microvasculature oxygen saturation. DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitation. A 1,064-nm OCT probe and 770-nm and 800-nm photothermal excitation beams are combined in a single-mode optical fiber to measure microvasculature hemoglobin oxygen saturation (SO(2)) levels in phantom blood vessels with a range of blood flow speeds (0 to 17  mm/s). A 50-μm-diameter blood vessel phantom is imaged, and SO(2) levels are measured using DWP-OCT and compared with values provided by a commercial oximeter at various blood oxygen concentrations. The influences of blood flow speed and mechanisms of SNR phase degradation on the accuracy of SO(2) measurement are identified and investigated.
authors: University of Texas at Austin, Departments of Electrical and Computer Engineering, Austin, TX 78712, USA.
authors: Biwei
authors: B
authors: Yin
authors: Roman V
authors: RV
authors: Kuranov
authors: Austin B
authors: AB
authors: McElroy
authors: Shams
authors: S
authors: Kazmi
authors: Andrew K
authors: AK
authors: Dunn
authors: Timothy Q
authors: TQ
authors: Duong
authors: Thomas E
authors: TE
authors: Milner
mesh_terms: D055806:Microvessels / Q000502:physiology*; D008955:Models, Cardiovascular; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000737:chemistry; D019047:Phantoms, Imaging; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D010108:Oxyhemoglobins; D010100:Oxygen
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