title: Multisensory control of hippocampal spatiotemporal selectivity.
abstract: The hippocampal cognitive map is thought to be driven by distal visual cues and self-motion cues. However, other sensory cues also influence place cells. Hence, we measured rat hippocampal activity in virtual reality (VR), where only distal visual and nonvestibular self-motion cues provided spatial information, and in the real world (RW). In VR, place cells showed robust spatial selectivity; however, only 20% were track active, compared with 45% in the RW. This indicates that distal visual and nonvestibular self-motion cues are sufficient to provide selectivity, but vestibular and other sensory cues present in RW are necessary to fully activate the place-cell population. In addition, bidirectional cells preferentially encoded distance along the track in VR, while encoding absolute position in RW. Taken together, these results suggest the differential contributions of these sensory cues in shaping the hippocampal population code. Theta frequency was reduced, and its speed dependence was abolished in VR, but phase precession was unaffected, constraining mechanisms governing both hippocampal theta oscillations and temporal coding. These results reveal cooperative and competitive interactions between sensory cues for control over hippocampal spatiotemporal selectivity and theta rhythm.
authors: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, 90095.|Department of Physics and Astronomy, University of California at Los Angeles, 90095.
authors: Pascal
authors: P
authors: Ravassard
authors: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, 90095.|Neuroscience Interdepartmental Program, University of California at Los Angeles, 90095.
authors: Ashley
authors: A
authors: Kees
authors: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, 90095.|Department of Physics and Astronomy, University of California at Los Angeles, 90095.
authors: Bernard
authors: B
authors: Willers
authors: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, 90095.|Neuroscience Interdepartmental Program, University of California at Los Angeles, 90095.
authors: David
authors: D
authors: Ho
authors: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, 90095.|Department of Physics and Astronomy, University of California at Los Angeles, 90095.
authors: Daniel A
authors: DA
authors: Aharoni
authors: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, 90095.|Department of Physics and Astronomy, University of California at Los Angeles, 90095.
authors: Jesse
authors: J
authors: Cushman
authors: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, 90095.|Department of Physics and Astronomy, University of California at Los Angeles, 90095.
authors: Zahra M
authors: ZM
authors: Aghajan
authors: W. M. Keck Center for Neurophysics, Integrative Center for Learning and Memory, and Brain Research Institute, University of California at Los Angeles, 90095.|Department of Physics and Astronomy, University of California at Los Angeles, 90095.|Neuroscience Interdepartmental Program, University of California at Los Angeles, 90095.|Departments of Neurology and Neurobiology, University of California at Los Angeles, 90095.
authors: Mayank R
authors: MR
authors: Mehta
mesh_terms: D000818:Animals; D001931:Brain Mapping; D003463:Cues; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D051381:Rats; D020332:Rats, Inbred LEC; D013028:Space Perception; D013037:Spatial Behavior; D013826:Theta Rhythm; D013998:Time Perception; D014584:User-Computer Interface
references: Nature. 1999 Feb 18;397(6720):613-6
references: 10050854
references: Science. 2008 Sep 5;321(5894):1322-7
references: 18772431
references: Hippocampus. 2012 Aug;22(8):1659-80
references: 22367959
references: Nature. 2002 Jun 13;417(6890):741-6
references: 12066185
references: J Neurophysiol. 2012 Apr;107(7):1822-34
references: 22219030
references: Hippocampus. 1993 Jul;3(3):317-30
references: 8353611
references: J Neurosci. 2007 Mar 21;27(12):3211-29
references: 17376982
references: Nat Neurosci. 2010 Nov;13(11):1433-40
references: 20890294
references: Proc Natl Acad Sci U S A. 2007 May 8;104(19):8149-54
references: 17470808
references: Neuron. 2000 Mar;25(3):707-15
references: 10774737
references: Nat Neurosci. 2012 Nov;15(11):1531-8
references: 23042081
references: Neuron. 2012 Feb 23;73(4):814-28
references: 22365553
references: Nature. 2009 Oct 15;461(7266):941-6
references: 19829374
references: J Neurosci. 1994 Nov;14(11 Pt 1):6553-63
references: 7965059
references: J Neurosci. 1996 Jan 15;16(2):823-35
references: 8551362
references: Nat Neurosci. 2006 Nov;9(11):1359-61
references: 17041594
references: J Neurosci. 2012 Jun 27;32(26):8952-68
references: 22745495
references: Nature. 2005 Aug 11;436(7052):801-6
references: 15965463
references: Hippocampus. 1996;6(3):271-80
references: 8841826
references: Hippocampus. 2008;18(12):1157-74
references: 19021256
references: Nature. 2008 Jun 26;453(7199):1248-52
references: 18480753
references: Brain Res. 1971 Nov;34(1):171-5
references: 5124915
references: Hippocampus. 2002;12(3):291-303
references: 12099481
references: J Neurophysiol. 2006 Jul;96(1):4-14
references: 16772515
references: Exp Brain Res. 1983;52(1):41-9
references: 6628596
references: Hippocampus. 2000;10(1):64-76
references: 10706218
references: J Neurosci. 2004 May 12;24(19):4541-50
references: 15140925
references: J Neurosci. 1987 Jul;7(7):1951-68
references: 3612226
references: Front Behav Neurosci. 2011 Oct 28;5:69
references: 22065409
references: Hippocampus. 2007;17(12):1252-71
references: 17924530