title: New coumarin derivatives as carbonic anhydrase inhibitors.
abstract: In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in vitro. Structures of these coumarins were confirmed by FT-IR, (1)H NMR, (13)C NMR and LC-MS analyses. Structure activity relationship study showed that 3d (IC50: 79 μM for hCA I and 88 μM for hCA II) performed higher inhibitory activity than others.
authors: Inonu University, Faculty of Arts and Sciences, Department of Chemistry 44280 , Malatya , Turkey.
authors: Mert Olgun
authors: MO
authors: Karataş
authors: Bülent
authors: B
authors: Alici
authors: Umit
authors: U
authors: Cakir
authors: Engin
authors: E
authors: Cetinkaya
authors: Dudu
authors: D
authors: Demir
authors: Adem
authors: A
authors: Ergün
authors: Nahit
authors: N
authors: Gençer
authors: Oktay
authors: O
authors: Arslan
mesh_terms: D024401:Carbonic Anhydrase I / Q000037:antagonists & inhibitors*; D024402:Carbonic Anhydrase II / Q000037:antagonists & inhibitors*; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D003374:Coumarins; D007527:Isoenzymes; D024401:Carbonic Anhydrase I; D024402:Carbonic Anhydrase II
keywords: benzimidazolium; carbonic anhydrase; coumarin; imidazolium; inhibition