title: Genetic diversity of Mycobacterium tuberculosis isolates from Inner Mongolia, China.
abstract: BACKGROUND
  Tuberculosis (TB) is a serious public health problem in China, and within China, Inner Mongolia has a high prevalence area of TB. Though studies on the genetic diversity of Mycobacterium tuberculosis (MTB) have been reported in many provinces, there are no such studies to date in Inner Mongolia. In this study, we investigated the genetic diversity of MTB in Inner Mongolia.
  
  
  RESULTS
  In this study, we analyzed 372 clinical MTB isolates with 22-loci mycobacterial interspersed repetitive unit and variable-number tandem repeats (MIRU-VNTR), spoligotyping, large sequence polymorphism (LSP), and NTF region analysis to understand the TB genotypes prevalent in Inner Mongolia. We found that the Beijing family was the most prevalent genotype (85.48%, 318/372), and the "modern" sublineage accounted for 76.73% (244/318) of the isolates. Our data also showed that there was no statistically significant association between the two major nationalities and the Beijing genotype (χ(2) = 3.612, P = 0.057; P>0.05).
  
  
  CONCLUSIONS
  The Beijing genotype is the most prevalent family of M. tuberculosis in Inner Mongolia, and we do not find any correlation between the Beijing genotype and the major nationalities.
authors: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control, Beijing, PR China.
authors: Qin
authors: Q
authors: Yu
authors: Yunkai
authors: Y
authors: Su
authors: Bing
authors: B
authors: Lu
authors: Yan
authors: Y
authors: Ma
authors: Xiuqin
authors: X
authors: Zhao
authors: Xiaomin
authors: X
authors: Yang
authors: Haiyan
authors: H
authors: Dong
authors: Yao
authors: Y
authors: Liu
authors: Lulu
authors: L
authors: Lian
authors: Li
authors: L
authors: Wan
authors: Yimou
authors: Y
authors: Wu
authors: Kanglin
authors: K
authors: Wan
mesh_terms: D002681:China; D005260:Female; D005798:Genes, Bacterial; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D058885:Multilocus Sequence Typing; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification; D015995:Prevalence; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000208:ethnology / Q000382:microbiology*
references: PLoS One. 2012;7(6):e38409
references: 22723859
references: BMC Infect Dis. 2008 Dec 22;8:170
references: 19102768
references: Zhonghua Liu Xing Bing Xue Za Zhi. 2007 Aug;28(8):785-8
references: 18080567
references: J Clin Microbiol. 1997 Apr;35(4):907-14
references: 9157152
references: PLoS One. 2012;7(3):e33904
references: 22479472
references: Lancet Infect Dis. 2010 Feb;10(2):103-11
references: 20113979
references: J Clin Microbiol. 2010 Nov;48(11):4102-6
references: 20739484
references: Tuber Lung Dis. 1998;79(1):31-42
references: 10645440
references: J Clin Microbiol. 2005 Jul;43(7):3185-91
references: 16000433
references: J Clin Microbiol. 2011 Apr;49(4):1354-62
references: 21325562
references: J Clin Microbiol. 2008 Aug;46(8):2692-9
references: 18550737
references: Int J Tuberc Lung Dis. 2010 Sep;14(9):1201-4
references: 20819269
references: Am J Respir Crit Care Med. 2004 Mar 1;169(5):610-4
references: 14701710
references: J Med Microbiol. 2010 Oct;59(Pt 10):1191-1197
references: 20576748
references: N Engl J Med. 1994 Jun 16;330(24):1703-9
references: 7910661
references: BMC Infect Dis. 2011 Oct 26;11:288
references: 22026819
references: J Clin Microbiol. 1995 Dec;33(12):3234-8
references: 8586708
references: Emerg Infect Dis. 2002 Aug;8(8):843-9
references: 12141971
references: J Clin Microbiol. 2004 Jun;42(6):2438-44
references: 15184416
references: Genome Res. 2005 Oct;15(10):1357-64
references: 16169923
references: Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1901-6
references: 11172048
references: JAMA. 2005 Jun 8;293(22):2726-31
references: 15941801
references: J Clin Microbiol. 1988 Nov;26(11):2465-6
references: 3069867
references: Chin Med J (Engl). 2007 May 5;120(9):814-9
references: 17531124
references: PLoS One. 2012;7(7):e41318
references: 22844457
references: Jpn J Infect Dis. 2012 Jul;65(4):341-4
references: 22814161
references: N Engl J Med. 2003 Sep 18;349(12):1149-56
references: 13679530