title: Plausible novel ribose metabolism catalyzed by enzymes of the methionine salvage pathway in Bacillus subtilis.
abstract: The methionine salvage pathway (MSP) recycles reduced sulfur from 5-methylthioribose. Here we propose a novel ribose metabolic pathway performed by MSP enzymes of Bacilli. MtnK, an initial catalyst of MSP, had significant ribose kinase activity, with Vmax and Km values of 2.9 µmol min(-1) mg of protein(-1) and 4.8 mM. Downstream enzymes catalyzed the isomerization of ribose-1-phosphate and subsequent dehydration, enolization, dephosphorylation, and dioxygenation.
authors: Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST), Takayama-cho, Ikoma, Nara, Japan. t-nakano1014@yahoo.co.jp
authors: Toshihiro
authors: T
authors: Nakano
authors: Yohtaro
authors: Y
authors: Saito
authors: Akiho
authors: A
authors: Yokota
authors: Hiroki
authors: H
authors: Ashida
mesh_terms: D001412:Bacillus subtilis / Q000201:enzymology*; D055162:Biocatalysis; D008715:Methionine / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D010766:Phosphorylation; D010770:Phosphotransferases / Q000378:metabolism*; D012266:Ribose / Q000378:metabolism*
chemical_list: D012266:Ribose; D008715:Methionine; D010770:Phosphotransferases; D010100:Oxygen