title: [Mechanism and risk factors of cardiogenic thromboembolism in patients with atrial fibrillation].
abstract: Atrial fibrillation (AF) is well known as one of the cardiogenic causes for thromboembolism. Here, the role of 3 important components as known Virchow's triad, blood coagulability, abnormalities in the blood flow, and the endocardial function of the atria, in thrombus formation in the fibrillating atria are discussed. In the experimental model, rapid atrial pacing acutely downregulated the gene expression of thrombomodulin(TM) and tissue factor pathway inhibitor (TFPI) in the atrial endocardium. In the clinical practice, CHADS2 score had been used for the risk stratification of thromboembolism in patients with AF. High CHADS2 score might be associated with abnormalities of left atrial blood flow or progression of fibrosis in the left atrial wall.
authors: Takayuki
authors: T
authors: Otsuka
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000503:physiopathology*; D001777:Blood Coagulation / Q000502:physiology; D004452:Echocardiography / Q000379:methods; D006801:Humans; D012307:Risk Factors; D020521:Stroke / Q000503:physiopathology; D013923:Thromboembolism / Q000503:physiopathology*