title: Dehydroepiandrosterone in women with premature ovarian failure and Hashimoto's thyroiditis.
abstract: We evaluated dehydroepiandrosterone sulfate (DHEAS) levels in premature ovarian failure (POF) patients with and without Hashimoto's thyroiditis, and the impact of DHEA supplementation on thyroid autoantibodies. In a retrospective case series, we included 67 women with spontaneous POF who received estrogen/gestagen replacement with or without DHEA (30 mg/day) for 3 months. Women who were seropositive for thyroglobulin antibodies and/or thyroperoxidase autoantibodies (n = 30) revealed lower pretherapeutic DHEAS levels (1.2 μg/ml, range 0.4-2.9 μg/ml vs. 1.9 μg/ml, range 0.2-3.9 μg/ml; p < 0.001). DHEAS showed an inverse correlation with both thyroglobulin antibodies (r = -0.426, p < 0.001) and thyroperoxidase autoantibodies (r = -0.362, p = 0.002). When treated with additional DHEA, significant decreases were found for thyroperoxidase autoantibodies (median 85.0 IU/ml, range 41-600 IU/ml vs. median 51.0 IU/ml, range 20-589 IU/ml; p = 0.005) but not for thyroglobulin antibodies.
authors: * Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna , Vienna.
authors: J
authors: J
authors: Ott
authors: P
authors: P
authors: Pecnik
authors: R
authors: R
authors: Promberger
authors: S
authors: S
authors: Pils
authors: R
authors: R
authors: Seemann
authors: M
authors: M
authors: Hermann
authors: P
authors: P
authors: Frigo
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D003687:Dehydroepiandrosterone / Q000008:administration & dosage*; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D015914:Estrogen Replacement Therapy; D005260:Female; D050031:Hashimoto Disease / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D016649:Primary Ovarian Insufficiency / Q000097:blood* / Q000188:drug therapy / Q000276:immunology*; D012189:Retrospective Studies
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D007453:Iodide Peroxidase