title: Incidence and associated factors of HIV drug resistance in Chinese HIV-infected patients receiving antiretroviral treatment.
abstract: BACKGROUND
  A critical indicator of the future success of highly active antiretroviral therapy (HAART) is the incidence of HIV drug resistance, which has not been studied in China on the national scale.
  
  
  METHODS
  HIV drug resistance baseline survey was conducted in the eight provinces with the largest numbers of patients on HAART in 2009, and a prospective cohort study with 12-month follow-up was completed in 2010. Patients completed an interviewer-administrated questionnaire and provided blood for CD4+ T-lymphocyte count (CD4 count), HIV viral load (VL), and HIV drug resistance genotyping. Factors associated with incidence of HIVDR were identified by Cox regression analysis.
  
  
  RESULTS
  The overall prevalence of HIV RNA ≥ 1000 copies/ml and HIVDR at baseline was 12.4% and 5.6%, respectively. Incidence of HIVDR in the one year follow-up was 3.5 per 100 person years. Independently associated factors were started treatment with a didanosine-based regimen, received care at township hospital or village clinic, low baseline CD4 counts, and high baseline VL.
  
  
  CONCLUSIONS
  The incidence of HIVDR in China was higher than that of some developed countries. China urgently needs to provide comprehensive education and training to doctors at village clinics and township hospitals to improve quality community-based care and treatment.
authors: State Key Laboratory for Infectious Disease Prevention and Control, and National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors: Hui
authors: H
authors: Xing
authors: Xia
authors: X
authors: Wang
authors: Lingjie
authors: L
authors: Liao
authors: Yanling
authors: Y
authors: Ma
authors: Bin
authors: B
authors: Su
authors: Jihua
authors: J
authors: Fu
authors: Jianmei
authors: J
authors: He
authors: Lin
authors: L
authors: Chen
authors: Xiaohong
authors: X
authors: Pan
authors: Yonghui
authors: Y
authors: Dong
authors: Wei
authors: W
authors: Liu
authors: Jenny H
authors: JH
authors: Hsi
authors: Liting
authors: L
authors: Yang
authors: Yuhua
authors: Y
authors: Ruan
authors: Yiming
authors: Y
authors: Shao
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology; D015497:HIV-1 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D009154:Mutation; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents
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