title: Effect of dopamine on Ehrlich ascites carcinoma cells.
abstract: Morphological studies showed that daily intraperitoneal injections of dopamine in doses of 10(-2)and 10(-1)M down-regulates the general number of cells in the Ehrlich ascites carcinoma in 10 and 30 times and decreases their diameter by 27% and 59%, respectively (as compared to the control animals received physiological saline). According to ultrastructural data these injections were followed by the abnormal changes in microvilluses, forming the specific moire fringes in cytosol, thickening of cortical layer, and a significant increase in filament reticulum density (actin fibers) in tumor cells of treatment group specimens. We concluded that the oncocytotoxic effect of dopamine was related to the induced polymerization of cytosol actin.
authors: Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Pushchino, Moscow Region, Russia. d_moshkov@mail.ru
authors: D A
authors: DA
authors: Moshkov
authors: S P
authors: SP
authors: Romanchenko
authors: E Yu
authors: EY
authors: Parnyshkova
authors: E N
authors: EN
authors: Bezgina
authors: S I
authors: SI
authors: Zaichkina
authors: L L
authors: LL
authors: Pavlik
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology*; D015259:Dopamine Agents / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008871:Microvilli / Q000187:drug effects
chemical_list: D000199:Actins; D015259:Dopamine Agents; D004298:Dopamine