title: The receptor tyrosine kinase Axl in cancer: biological functions and therapeutic implications.
abstract: The receptor tyrosine kinase Axl has been implicated in the malignancy of different types of cancer. Emerging evidence of Axl upregulation in numerous cancers, as well as reports demonstrating that its inhibition blocks tumor formation in animal models, highlight the importance of Axl as a new potential therapeutic target. Furthermore, recent data demonstrate that Axl plays a pivotal role in resistance to chemotherapeutic regimens. In this review we discuss the functions of Axl and its regulation and role in cancer development, resistance to therapy, and its importance as a potential drug target, focusing on acute myeloid leukemia, breast, prostate and non-small cell lung cancers.
authors: International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa; Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa.
authors: Juliano D
authors: JD
authors: Paccez
authors: Matjaz
authors: M
authors: Vogelsang
authors: M Iqbal
authors: MI
authors: Parker
authors: Luiz F
authors: LF
authors: Zerbini
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology; D002289:Carcinoma, Non-Small-Cell Lung / Q000209:etiology; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000209:etiology; D008175:Lung Neoplasms / Q000209:etiology; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology*; D011471:Prostatic Neoplasms / Q000209:etiology; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D000094963:Axl Receptor Tyrosine Kinase
chemical_list: D011518:Proto-Oncogene Proteins; D020794:Receptor Protein-Tyrosine Kinases; D000094963:Axl Receptor Tyrosine Kinase; C000722289:AXL protein, human
keywords: Axl; cancer; cancer therapy; drug resistance; receptor tyrosine kinases