title: MiR-17-92 cluster is a novel regulatory gene of cardiac ischemic/reperfusion injury.
abstract: The miR-17-92 cluster is an important microRNA cluster in the animals. It was mainly investigated as an oncogene in tumors but never studied in cardiovascular disease. On one aspect, miR-17-92 cluster is documented to play anti-apoptotic roles in tumor cells, including hypoxia-induced apoptosis. The families of miR-17, miR-19, and miR-92 promote resistance to apoptosis by directly inhibiting pro-apoptotic protein, and by the two major cell survival signaling pathways-PI3K/AKT, and MAPK/ERK. On the other aspect, the component members of miR-17-92 cluster are high expressed in the hearts of canine and mice, suggesting that there are effect targets of the cluster in the myocardium. So that, we hypothesized that the miR-17-92 cluster may protect the heart by diminishing the apoptosis and alleviating ischemia/reperfusion injury. This may be a new regulating target for patients with myocardial infarction and undergoing cardiac surgery.
authors: Department of Cardiac Surgery, Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China.
authors: Mi
authors: M
authors: Zhou
authors: Junfeng
authors: J
authors: Cai
authors: Yaoliang
authors: Y
authors: Tang
authors: Qiang
authors: Q
authors: Zhao
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D001483:Base Sequence; D005809:Genes, Regulator; D051379:Mice; D035683:MicroRNAs / Q000502:physiology*; D008962:Models, Theoretical; D005810:Multigene Family; D015428:Myocardial Reperfusion Injury / Q000235:genetics*
chemical_list: C575895:MIRN17-92 microRNA, mouse; D035683:MicroRNAs