title: Surgical treatment of impending and pathological fractures of tibia.
abstract: Advances in adjuvant and neoadjuvant therapies have improved the prognosis of cancer patients leading to an increasing incidence of bone metastases and consequent long bone fractures. In the present study the authors consider the indications and the different surgical options of treatment of tibial pathological lesions. 13 patients (14 lesions, 6 pathological fractures), treated according to histotype and lesion localisation, were retrospectively evaluated. Using generic outcome instruments such as the Eastern Cooperative Oncology Group (ECOG) and Quality of life questionnaire of European Organization for Research and Treatment of Cancer (QLQ-C30) pain, mobility and use of analgesics were evaluated before and after surgery. In all patients, mechanical stabilisation of the osteolytic lesion was achieved. There were no pathological fractures, and no implant mechanical failure. All patients reported pain relief, with a relevant reduction in the amount of analgesics used. Surgical treatment of tibial metastases has to be decided taking into consideration the histotype, localisation of the metastases and life expectancy. The treatment has to be all-encompassing in a solitary lesion in patients with a good prognosis but less invasive in plurimetastatic patients with poor prognosis. Acquisition of good mechanical stability is crucial for a successful outcome.
authors: Ortopedia Oncologica, Centro Oncologico di Palazzo Baleani, Azienda Policlinico Umberto I, Rome, Italy. piccioli.andrea@gmail.com
authors: A
authors: A
authors: Piccioli
authors: G
authors: G
authors: Maccauro
authors: L
authors: L
authors: Scaramuzzo
authors: C
authors: C
authors: Graci
authors: M S
authors: MS
authors: Spinelli
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000150:complications / Q000601:surgery*; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods; D059408:Pain Management / Q000379:methods; D011379:Prognosis; D011788:Quality of Life; D011878:Radiotherapy; D012189:Retrospective Studies; D013534:Survival; D013977:Tibia / Q000293:injuries* / Q000601:surgery; D013978:Tibial Fractures / Q000601:surgery*; D016896:Treatment Outcome