title: [Barrier elements of chromatin domains and nuclear envelope].
abstract: The results of investigating the functions of different barrier elements, including insulators and MARs/SARs and the models of their effect, are described. The functions of neDNA (DNA from the nuclear envelopes) as a barrier element that protects the transgene from position-effect variegation and its interaction with insulators are discussed. The possible mechanisms of the functioning of structural and functional units of eukaryotic chromosomes of different species are suggested.
authors: Koltsov Institute of Developmental Biology, Moscow, Russia
authors: A N
authors: AN
authors: Shabarina
authors: M V
authors: MV
authors: Glazkov
mesh_terms: D000818:Animals; D002843:Chromatin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D055012:Chromosomal Position Effects; D006801:Humans; D038101:Insulator Elements; D009685:Nuclear Envelope / Q000378:metabolism*; D034521:Nuclear Matrix-Associated Proteins / Q000378:metabolism; D019076:Transgenes
chemical_list: D002843:Chromatin; D034521:Nuclear Matrix-Associated Proteins