title: Risk factors for mild cognitive impairment among Mexican Americans.
abstract: BACKGROUND
  Although a great deal of literature has focused on risk factors for mild cognitive impairment (MCI), little published work examines risk for MCI among Mexican Americans.
  
  
  METHODS
  Data from 1628 participants (non-Hispanic n = 1002; Mexican American n = 626) were analyzed from two ongoing studies of cognitive aging and Alzheimer's disease, Project FRONTIER (Facing Rural Obstacles to health Now Through Intervention, Education & Research) and TARCC (Texas Alzheimer's Research & Care Consortium).
  
  
  RESULTS
  When looking at the full cohorts (non-Hispanic and Mexican American), age, education, Apolipoprotein E (APOE) ε4 status and gender were consistently related to MCI diagnosis across the two cohorts. However, when split by ethnicity, advancing age was the only significant risk factor for MCI among Mexican Americans across both cohorts.
  
  
  CONCLUSIONS
  The current data suggest that many of the previously established risk factors for MCI among non-Hispanic cohorts may not be predictive of MCI among Mexican Americans and point to the need for additional work aimed at understanding factors related to cognitive aging among this underserved segment of the population.
authors: Department of Internal Medicine, University of North Texas Health Sciences Center, Fort Worth, TX, USA; Institute for Aging & Alzheimer's Disease Research, University of North Texas Health Sciences Center, Fort Worth, TX, USA. Electronic address: Sid.O'Bryant@unthsc.edu.
authors: Sid E
authors: SE
authors: O'Bryant
authors: Leigh
authors: L
authors: Johnson
authors: Joan
authors: J
authors: Reisch
authors: Melissa
authors: M
authors: Edwards
authors: James
authors: J
authors: Hall
authors: Robert
authors: R
authors: Barber
authors: Michael D
authors: MD
authors: Devous
authors: Donald
authors: D
authors: Royall
authors: Meharvan
authors: M
authors: Singh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics; D060825:Cognitive Dysfunction / Q000453:epidemiology* / Q000208:ethnology* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D017058:Mexican Americans / Q000706:statistics & numerical data*; D008875:Middle Aged; D012307:Risk Factors; D013781:Texas / Q000453:epidemiology; D044465:White People
chemical_list: D001057:Apolipoproteins E
keywords: Alzheimer's disease; Cognition; Cross-cultural; Ethnicity; Mexican American; Mild cognitive impairment; Risk factors
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