title: Helicobacter pylori infection and atrophic gastritis.
abstract: BACKGROUND
  Helicobacter pylori-infection associated gastritis is known to be a significant risk factor of gastric cancer. Serum levels of Gastrin-17 and Pepsinogen1which are respectively biomarkers of gastric antral and corpus mucosal activity are well known parameters of atrophic gastritis.
  
  
  OBJECTIVE
  To determine the prevalence of Helicobacter pylori and atrophic gastritis amongst dyspeptic patients and to compare the production of PGI and G-17 in the various atrophic stages.
  
  
  METHODS
  A total of 139 dyspeptic patients aged 46.68±15.50 years [females 106 aged47.23±15.51years, males 33 aged 44.48±14.62] were included during the one year period, March 2008-april 2009 at the district hospital Tombel. The degree of atrophy was determined by the levels of serum pepsinogen1, and gastrin-17 and the presence of Helicobacter pylori antibodies detected by an enzyme immunoassay.
  
  
  RESULTS
  The prevalence of Helicobacter pylori was 79.82% and that for atrophic gastritis was 6.6%. A decrease in mean serum levels of gastin-17 along with increasing antral atrophy was observed; the mean serum levels of pepsinogen1 were reduced during progression of corpus atrophy.
  
  
  CONCLUSIONS
  A weak reverse correlation(r =-0.036) was found between Gastrin-17 and Helicobacter pylori antibodies.
authors: Faculty of Medicine and Biomedical Sciences, University of Yaounde 1/The Yaounde Initiative Foundation, Yaounde, Cameroon. alolevo@yahoo.com
authors: I A
authors: IA
authors: Ebule
authors: A N
authors: AN
authors: Longdoh
authors: I L
authors: IL
authors: Paloheimo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D002163:Cameroon / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004415:Dyspepsia / Q000453:epidemiology; D005260:Female; D005755:Gastrins / Q000097:blood*; D005757:Gastritis, Atrophic / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood*; D015995:Prevalence; D012307:Risk Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D005755:Gastrins; C013550:gastrin 17; D020116:Pepsinogen A
keywords: Helicobacter pylori; atrophic gastritis; gastrin; pepsinogen
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