title: Delivery of poorly soluble compounds by amorphous solid dispersions.
abstract: Solid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in this area, with focus on the fundamentals, characterization, formulation development and manufacturing of amorphous solid dispersions as well as the new generation amorphization technologies. Additionally, specific applications of amorphous solid dispersion in the formulation of herbal drugs or bioactive natural products are reviewed to reflect the growing interest in this relatively neglected area.
authors: Thomas W Y
authors: TW
authors: Lee
authors: Nathan A
authors: NA
authors: Boersen
authors: H W
authors: HW
authors: Hui
authors: S F
authors: SF
authors: Chow
authors: K Y
authors: KY
authors: Wan
authors: School of Pharmacy, The Chinese University of Hong Kong, Room 801E, Lo Kwee-Seong Integrated Biomedical Sciences Building, Shatin, N.T. Hong Kong. albert-chow@cuhk.edu.hk.
authors: Albert H L
authors: AH
authors: Chow
mesh_terms: D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry* / Q000378:metabolism; D028321:Plant Preparations / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D012995:Solubility; D012996:Solutions; D013816:Thermodynamics
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D028321:Plant Preparations; D012996:Solutions