title: Investigation of the clinicopathological features of fallopian tube malignancy.
abstract: The present study investigated the clinico-pathological features of fallopian tube malignancy (FTM) and elucidated the biological behavior of this disorder. Data were compiled concerning FTM from 68 patients from 7 institutes. The patients included 60 cases with fallopian tube carcinoma and 8 cases with fallopian tube carcinosarcoma. The clinical stage was stage III or higher in 72% of the cases. A complete response or partial response was achieved in 56 and 10 of the 68 patients with FTM, respectively, indicating a response rate of 97.1%. The median observation period for FTM was 41 months (3 to 126 months). Three of the 19 patients with stage I/II disease (16%) and 31 of the 49 patients with stage III/IV disease (63%) experienced recurrence, with a median progression-free survival of 17.5 months, and a 3-year overall survival of 77.2%. Regarding the site of recurrence, local intraperitoneal recurrence (26.2%) and solitary recurrences in lymph nodes (19.0%) and in the liver (16.7%) were relatively frequent. Secondary debulking surgery (SDS) was performed in 15 patients (44%) out of the 34 recurrent FTMs. Conversely, recurrence was associated with ascites (carcinomatous peritonitis) in 4 of the 34 recurrent patients, but all 4 patients died. The median survival period after recurrence was 28 months: 7.5 and 30 months with and without ascites, respectively (P<0.001). A univariate analysis showed that prognosis was significantly correlated only with whether SDS could be performed. These results suggest that since FTM frequently results in solitary recurrence, aggressive recurrence treatment including SDS could improve prognosis.
authors: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan. yokoyama@cc.hirosaki-u.ac.jp
authors: Yoshihito
authors: Y
authors: Yokoyama
authors: Masayuki
authors: M
authors: Futagami
authors: Toshio
authors: T
authors: Fujimoto
authors: Yukihiro
authors: Y
authors: Terada
authors: Eriko
authors: E
authors: Takatori
authors: Toru
authors: T
authors: Sugiyama
authors: Takeo
authors: T
authors: Otsuki
authors: Nobuo
authors: N
authors: Yaegashi
authors: Takanobu
authors: T
authors: Kojimahara
authors: Hirohisa
authors: H
authors: Kurachi
authors: Hiroshi
authors: H
authors: Nishiyama
authors: Keiya
authors: K
authors: Fujimori
authors: Toru
authors: T
authors: Tase
authors: Hideki
authors: H
authors: Mizunuma
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005185:Fallopian Tube Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D005187:Fallopian Tubes / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome