title: Bone graft substitutes currently available in orthopaedic practice: the evidence for their use.
abstract: We reviewed 59 bone graft substitutes marketed by 17 companies currently available for implantation in the United Kingdom, with the aim of assessing the peer-reviewed literature to facilitate informed decision-making regarding their use in clinical practice. After critical analysis of the literature, only 22 products (37%) had any clinical data. Norian SRS (Synthes), Vitoss (Orthovita), Cortoss (Orthovita) and Alpha-BSM (Etex) had Level I evidence. We question the need for so many different products, especially with limited published clinical evidence for their efficacy, and conclude that there is a considerable need for further prospective randomised trials to facilitate informed decision-making with regard to the use of current and future bone graft substitutes in clinical practice.
authors: Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom
authors: T
authors: T
authors: Kurien
authors: R G
authors: RG
authors: Pearson
authors: B E
authors: BE
authors: Scammell
mesh_terms: D001847:Bone Diseases / Q000601:surgery*; D018786:Bone Substitutes / Q000494:pharmacology / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000000981:diagnostic imaging*; D050723:Fractures, Bone / Q000601:surgery*; D006801:Humans; D007592:Joint Diseases / Q000601:surgery*; D011859:Radiography; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D018786:Bone Substitutes