title: A two-dimensional model for studying tumor angiogenesis inhibitors.
abstract: Inhibition of angiogenesis can attenuate tumor growth. Hence, mathematical modeling of tumor-induced angiogenesis can be a tool for predicting outcome of angiogenesis inhibitors. We have generated a two-dimensional cornea model of angiogenesis and have tested the effectiveness of the inhibitor through testing representative examples. The effects of thrombospondin and the way it interacts in the cornea with the endothelial cells and tumor angiogenic factors were examined. We were then able to define the inhibitor's role specific to our benchmark model. Finally, a thorough sensitivity analysis was performed to verify baseline values and determine the precise effects of the different parameters. Our findings can be used to design strategies involving manufacturing inhibitors to regulate the angiogenesis process.
authors: Department of Oncology, General Hospital of Chinese PLA, Beijing, China.
authors: Ping
authors: P
authors: Gao
authors: Jun-Lan
authors: JL
authors: Yang
authors: Huan
authors: H
authors: Wang
authors: Xiao-Dong
authors: XD
authors: Wu
authors: Shun-Chang
authors: SC
authors: Jiao
mesh_terms: D000465:Algorithms; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D042501:Angiogenic Proteins / Q000502:physiology; D001163:Arteriovenous Anastomosis; D003198:Computer Simulation; D003315:Cornea / Q000098:blood supply; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy*
chemical_list: D020533:Angiogenesis Inhibitors; D042501:Angiogenic Proteins