title: Lycospidine A, a new type of Lycopodium alkaloid from Lycopodium complanatum.
abstract: Lycospidine A (1), the first example of a Lycopodium alkaloid which contains an unprecedented five-membered A ring, was isolated from Lycopodium complanatum. The unique five-membered A ring in 1 indicates that carbons 2-5 in 1 are presumably derived from proline instead of the lysine biosynthetically, which suggests that 1 represent a new class of Lycopodium alkaloid. In addition, the unique structural feature and biosynthetic origin of 1 shed new insight into the structural diversity of Lycopodium alkaloid analogue libraries potentially accessible by engineered biosynthesis.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences, Kunming 650201, People's Republic of China, and University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
authors: Jin-Tang
authors: JT
authors: Cheng
authors: Fei
authors: F
authors: Liu
authors: Xiao-Nian
authors: XN
authors: Li
authors: Xing-De
authors: XD
authors: Wu
authors: Liao-Bin
authors: LB
authors: Dong
authors: Li-Yan
authors: LY
authors: Peng
authors: Sheng-Xiong
authors: SX
authors: Huang
authors: Juan
authors: J
authors: He
authors: Qin-Shi
authors: QS
authors: Zhao
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification*; D032502:Lycopodium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D006576:Heterocyclic Compounds, 4 or More Rings; C000588531:lycospidine A