title: Mitochondrial mechanisms of neuroglobin's neuroprotection.
abstract: Neuroglobin (Ngb) is an oxygen-binding globin protein that has been demonstrated to be neuroprotective against stroke and related neurological disorders. However, the underlying mechanisms of Ngb's neuroprotection remain largely undefined. Mitochondria play critical roles in multiple physiological pathways including cell respiration, energy production, free radical generation, and cellular homeostasis and apoptosis. Mitochondrial dysfunction is widely involved in the pathogenesis of stroke and neurodegenerative diseases including Alzheimer's, Parkinson's, and Huntington's diseases. Accumulating evidence showed that elevated Ngb level is associated with preserved mitochondrial function, suggesting that Ngb may play neuroprotective roles through mitochondria-mediated pathways. In this paper we briefly discuss the mitochondria-related mechanisms in Ngb's neuroprotection, especially those involved in ATP production, ROS generation and scavenging, and mitochondria-mediated cell death signaling pathways.
authors: Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA. zyu@partners.org
authors: Zhanyang
authors: Z
authors: Yu
authors: Jessica L
authors: JL
authors: Poppe
authors: Xiaoying
authors: X
authors: Wang
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D005914:Globins / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D000078787:Neuroglobin; D018696:Neuroprotective Agents / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D020521:Stroke / Q000378:metabolism / Q000473:pathology
chemical_list: D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate; D005914:Globins
references: Biochim Biophys Acta. 2009 Sep;1793(9):1508-15
references: 19289147
references: Biochem J. 1999 Jul 15;341 ( Pt 2):233-49
references: 10393078
references: J Neurosci Res. 2012 Jun;90(6):1183-9
references: 22345048
references: N Engl J Med. 2011 Jun 2;364(22):2138-46
references: 21631326
references: FASEB J. 2008 Jun;22(6):1737-47
references: 18198211
references: Pharmacology. 2003 Nov;69(3):150-7
references: 14512702
references: Biochim Biophys Acta. 2007 Aug;1773(8):1341-8
references: 17306896
references: Stroke. 2001 Apr;32(4):1000-4
references: 11283403
references: Stroke. 2004 Nov;35(11 Suppl 1):2726-30
references: 15459442
references: Neurobiol Aging. 2008 Dec;29(12):1815-22
references: 17560688
references: Trends Cell Biol. 2010 Feb;20(2):102-12
references: 20006503
references: Stroke. 2008 Jun;39(6):1869-74
references: 18403737
references: Neuron. 2008 Dec 10;60(5):748-66
references: 19081372
references: Biochem J. 2005 Dec 1;392(Pt 2):399-406
references: 15966870
references: Arch Biochem Biophys. 2009 Apr 1;484(1):87-93
references: 19467633
references: J Cell Biol. 2010 Apr 19;189(2):211-21
references: 20404107
references: Proteins. 2011 Jan;79(1):115-25
references: 20938977
references: Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15306-11
references: 11742077
references: Curr Opin Pharmacol. 2008 Feb;8(1):20-4
references: 17942367
references: PLoS One. 2011;6(6):e20478
references: 21674044
references: FEBS Lett. 2006 Sep 4;580(20):4884-8
references: 16914148
references: AAPS J. 2006 Aug 18;8(3):E521-31
references: 17025271
references: PLoS One. 2011;6(12):e28160
references: 22164238
references: IUBMB Life. 2008 Jul;60(7):448-55
references: 18465792
references: Oncogene. 2001 Mar 26;20(13):1653-60
references: 11313913
references: Int J Mol Sci. 2012;13(6):6995-7014
references: 22837676
references: J Cereb Blood Flow Metab. 1995 Mar;15(2):242-7
references: 7860658
references: Biochim Biophys Acta. 2009 May;1787(5):402-13
references: 18848916
references: Biochim Biophys Acta. 2010 Jan;1802(1):80-91
references: 19751827
references: Neurobiol Dis. 1996 Apr;3(2):149-57
references: 9173922
references: Biochem Biophys Res Commun. 2009 Dec 4;390(1):121-4
references: 19782043
references: J Cereb Blood Flow Metab. 1992 Jan;12(1):25-33
references: 1727140
references: Biochim Biophys Acta. 2006 May-Jun;1763(5-6):450-62
references: 16624426
references: Nat Cell Biol. 2003 Dec;5(12):1051-61
references: 14608362
references: Nature. 2000 Sep 28;407(6803):520-3
references: 11029004
references: Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3497-500
references: 12621155
references: Hum Mol Genet. 2009 Oct 15;18(R2):R169-76
references: 19808793
references: Free Radic Biol Med. 2006 Jun 15;40(12):2223-31
references: 16785036
references: Proc Natl Acad Sci U S A. 1995 May 23;92(11):5057-61
references: 7761448
references: Ann N Y Acad Sci. 2008 Dec;1147:283-92
references: 19076450
references: J Biol Chem. 2003 Feb 14;278(7):4919-25
references: 12480932
references: Am J Pathol. 2011 Dec;179(6):2788-97
references: 21967817
references: IUBMB Life. 2010 Dec;62(12):878-85
references: 21190290
references: Methods Enzymol. 2005;396:207-14
references: 16291234
references: Brain Res Mol Brain Res. 1998 May;56(1-2):186-91
references: 9602121
references: Ann N Y Acad Sci. 2011 Jan;1215:161-9
references: 21261655
references: Br J Pharmacol. 1998 Jun;124(4):756-62
references: 9690868
references: Gene. 2007 Aug 15;398(1-2):114-22
references: 17532579
references: APMIS. 2007 Feb;115(2):81-103
references: 17295675
references: Nat Rev Neurosci. 2008 Jul;9(7):505-18
references: 18568013
references: J Neurosci Res. 2007 Nov 15;85(15):3407-15
references: 17847081
references: Apoptosis. 2010 Apr;15(4):401-11
references: 20091232
references: J Neurochem. 2006 May;97(3):724-36
references: 16606371
references: Free Radic Biol Med. 2000 Aug;29(3-4):222-30
references: 11035250
references: J Bioenerg Biomembr. 2008 Oct;40(5):445-56
references: 18843528
references: J Neurochem. 1999 Sep;73(3):1189-99
references: 10461911
references: Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18314-9
references: 17116881
references: Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19114-9
references: 18025470
references: Oncogene. 2003 Aug 28;22(36):5579-85
references: 12944905
references: J Biol Chem. 2007 Dec 28;282(52):37448-53
references: 17956863
references: Nat Cell Biol. 2010 Feb;12(2):119-31
references: 20098416
references: J Biol Chem. 2001 Oct 12;276(41):37887-94
references: 11483608
references: J Cereb Blood Flow Metab. 2010 Nov;30(11):1874-82
references: 20571522
references: Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8483-8
references: 15932948
references: Biochim Biophys Acta. 2009 May;1787(5):335-44
references: 19268425
references: Neuron. 2005 Aug 4;47(3):379-93
references: 16055062
references: Nat Rev Mol Cell Biol. 2008 Jan;9(1):47-59
references: 18097445
references: Biochim Biophys Acta. 2012 Dec;1823(12):2261-73
references: 23036890
references: Stroke. 2009 Sep;40(9):3149-55
references: 19478227
references: FEBS Lett. 2003 Jun 12;545(1):39-46
references: 12788490
references: Biochem Biophys Res Commun. 2012 Aug 17;425(1):100-6
references: 22820193
references: FASEB J. 2006 Nov;20(13):2192-7
references: 17077295
references: J Cereb Blood Flow Metab. 1998 Mar;18(3):238-47
references: 9498840
references: IUBMB Life. 2004 Nov-Dec;56(11-12):671-9
references: 15804831
references: J Cereb Blood Flow Metab. 2005 Jun;25(6):694-712
references: 15716857
references: Trends Mol Med. 2003 Apr;9(4):169-76
references: 12727143
references: J Cereb Blood Flow Metab. 1998 Feb;18(2):196-205
references: 9469163
references: Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14126-31
references: 11717466
references: Nat Med. 2003 Sep;9(9):1180-6
references: 12937412
references: Brain Res Bull. 2000 Nov 1;53(4):399-407
references: 11136995
references: Arch Biochem Biophys. 2003 Nov 15;419(2):198-206
references: 14592463
references: Neuron. 2002 Dec 19;36(6):1063-77
references: 12495622
references: EMBO J. 2001 Jun 1;20(11):2690-701
references: 11387204
references: Neurobiol Dis. 1997;4(3-4):288-300
references: 9361306
references: J Biol Chem. 2003 Sep 19;278(38):36505-12
references: 12860983
references: Neurosci Lett. 2008 Jan 10;430(2):135-7
references: 18035490
references: Metab Brain Dis. 2002 Sep;17(3):143-51
references: 12322785
references: Nat Rev Mol Cell Biol. 2003 Jul;4(7):552-65
references: 12838338
references: Hum Mol Genet. 2011 May 1;20(9):1726-37
references: 21296869
references: J Neurosci. 2011 Mar 16;31(11):3990-9
references: 21411642
references: PLoS One. 2011;6(6):e20975
references: 21687634
references: Life Sci. 2002 Jun 28;71(6):655-65
references: 12072154
references: J Biol Chem. 2005 May 27;280(21):20493-502
references: 15772080
references: J Neurosci Res. 2009 Jan;87(1):164-70
references: 18711728
references: J Biol Chem. 1992 Mar 15;267(8):5317-23
references: 1312087
references: Expert Rev Neurother. 2012 May;12(5):535-43
references: 22550982
references: Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17944-8
references: 17098866
references: Mol Brain. 2009 Jul 29;2:24
references: 19640278
references: J Neurotrauma. 2011 Oct;28(10):2123-34
references: 21732763
references: Neuron. 1995 Feb;14(2):303-15
references: 7857640
references: Br J Pharmacol. 2002 Jan;135(1):103-12
references: 11786485
references: J Cell Biol. 2006 May 22;173(4):459-61
references: 16717123
references: Int J Mol Sci. 2010 May 27;11(6):2306-21
references: 20640154
references: Physiol Rev. 2007 Jan;87(1):315-424
references: 17237348
references: Free Radic Biol Med. 1999 Nov;27(9-10):1122-32
references: 10569645
references: Neuroscience. 2012 Aug 30;218:235-42
references: 22659017
references: Cell Calcium. 2002 Nov-Dec;32(5-6):413-20
references: 12543100
references: News Physiol Sci. 2004 Jun;19:110-3
references: 15143204
references: J Biol Chem. 2005 Oct 21;280(42):35767-75
references: 16115861
references: EMBO J. 2006 Aug 23;25(16):3900-11
references: 16874299
references: Neuroscience. 2012 Jan 3;200:99-105
references: 22079573
references: J Neurosci Res. 2004 May 15;76(4):519-27
references: 15114624
references: J Comp Neurol. 2010 May 1;518(9):1556-69
references: 20187147
references: J Neurochem. 2009 Mar;108(5):1143-54
references: 19154338
references: Nat Rev Mol Cell Biol. 2008 Mar;9(3):231-41
references: 18073771
references: Antioxid Redox Signal. 2010 Sep 15;13(6):769-81
references: 20367258
references: J Biol Chem. 2003 Jan 17;278(3):1932-5
references: 12409290
references: Science. 1999 Mar 5;283(5407):1488-93
references: 10066163
references: J Cell Sci. 2005 Dec 1;118(Pt 23):5411-9
references: 16306220
references: Gene. 2007 Aug 15;398(1-2):103-13
references: 17555889
references: Stroke. 2008 Feb;39(2):455-62
references: 18174477
references: Traffic. 2007 Dec;8(12):1668-1675
references: 17944806