title: Cardiovascular disease risk factors in women with a history of early-onset preeclampsia.
abstract: OBJECTIVE
  To assess the prevalence of established cardiovascular disease risk factors and to estimate 10-year absolute risk of cardiovascular disease after early-onset preeclampsia.
  
  
  METHODS
  We assessed major cardiovascular disease risk factors in 243 primiparous women with a history of early-onset preeclampsia (delivery at less than 34 weeks of gestation) at least 6 months after delivery; 374 healthy nonpregnant women of similar age served as a reference group.
  
  
  RESULTS
  After adjustment for age, we observed significantly higher means for body mass index, blood pressure, total and low-density lipoprotein cholesterol, triglycerides, glucose, and lower mean high-density lipoprotein cholesterol (all P<.01) in women with previous early-onset preeclampsia compared with the reference group. Prevalence of the metabolic syndrome was 15.2% compared with 4.3% (P<.001), two or more major cardiovascular disease risk factors were present in 51.0% compared with 26.5%, and three or more risk factors were present in 18.9% compared with 6.4%, respectively. Mean estimated 10-year cardiovascular disease risks by the Framingham Risk Score were 1.08% (95% confidence interval 1.04-1.12) and 1.01% (95% CI 1.00-1.01; P<.001) for the difference.
  
  
  CONCLUSIONS
  Women with a history of early-onset preeclampsia have a high prevalence of several major cardiovascular disease risk factors. Although the estimated 10-year cardiovascular disease risk is low (less than 5%) after delivery, cardiovascular disease risk is expected to increase rapidly with increasing age.
  
  
  METHODS
  II.
authors: Division of Perinatology and Gynecology, the Laboratory for Clinical Chemistry and Hematology, and the Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; and the Division of Human Development and Health, University of Southampton, Southamptom, United Kingdom.
authors: Bas B
authors: BB
authors: van Rijn
authors: Marie-Elise
authors: ME
authors: Nijdam
authors: Hein W
authors: HW
authors: Bruinse
authors: Mark
authors: M
authors: Roest
authors: Cuno S
authors: CS
authors: Uiterwaal
authors: Diederick E
authors: DE
authors: Grobbee
authors: Michiel L
authors: ML
authors: Bots
authors: Arie
authors: A
authors: Franx
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia; D011247:Pregnancy; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors
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