title: Multivalent alteration of quorum sensing in Staphylococcus aureus.
abstract: Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptide-polymer conjugates. Our results show that by attaching multiple AIP-4' units to macromolecular scaffolds, the agr QS response in S. aureus was affected strongly, while displaying a clear multivalency effect.
authors: Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors: Sarit
authors: S
authors: Melamed Yerushalmi
authors: Maren E
authors: ME
authors: Buck
authors: David M
authors: DM
authors: Lynn
authors: N Gabriel
authors: NG
authors: Lemcoff
authors: Michael M
authors: MM
authors: Meijler
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D053038:Quorum Sensing / Q000187:drug effects*; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D011108:Polymers