title: Phosphate induced crystal acute kidney injury - an under-recognized cause of acute kidney injury potentially leading to chronic kidney disease: case report and review of the literature.
abstract: Acute phosphate nephropathy or nephrocalcinosis is a tubulointerstitial nephropathy characterized by tubular calcium phosphate deposition - crystal nephropathy - and slowly progressive renal insufficiency during or following treatment with preparations containing sodium phosphate. We report a patient who developed nephrocalcinosis (crystal induced acute kidney injury) following the administration of a combination of oral and rectal sodium phosphate for treatment of postoperative constipation. A timely renal replacement therapy procedure may reverse the process of crystallization and the irreversible slope towards chronic dialysis.
authors: Intensive Care Dept, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
authors: S
authors: S
authors: Lochy
authors: R
authors: R
authors: Jacobs
authors: P M
authors: PM
authors: Honoré
authors: E
authors: E
authors: De Waele
authors: O
authors: O
authors: Joannes-Boyau
authors: J
authors: J
authors: De Regt
authors: V
authors: V
authors: Van Gorp
authors: H D
authors: HD
authors: Spapen
keywords: CRRT; acute phosphate nephropathy; crystal induced nephropathy; dialysis; hemofiltration; hyperphosphatemie; worse prognosis
references: Clin Toxicol (Phila). 2009 Nov;47(9):859-69
references: 19852621
references: Arch Intern Med. 2003 Apr 14;163(7):803-8
references: 12695271
references: Neth J Med. 2008 Nov;66(10):438-41
references: 19011271
references: Intern Med. 2008;47(7):643-6
references: 18379152
references: Rev Med Suisse. 2011 Nov 16;7(317):2227-8, 2230-1
references: 22400350
references: Clin Nephrol. 2001 Nov;56(5):398-401
references: 11758013
references: Expert Opin Drug Saf. 2008 Mar;7(2):147-58
references: 18324877
references: Am J Kidney Dis. 2007 Dec;50(6):1053; author reply 1053-4
references: 18037110
references: Clin J Am Soc Nephrol. 2008 Sep;3(5):1494-503
references: 18596115
references: J Am Soc Nephrol. 2005 Nov;16(11):3389-96
references: 16192415
references: Clin Sci (Lond). 2004 Jun;106(6):549-61
references: 15027893