title: Large bilateral foveal cysts in the inner retina of a patient treated with tamoxifen, diagnosed with Fourier-domain optical coherence tomography.
abstract: OBJECTIVE
  To report a case of a patient receiving tamoxifen with visual deterioration and describe the unusual optical coherence tomography (OCT) findings.
  
  
  METHODS
  Observational case report.
  
  
  RESULTS
  A 55-year-old female patient was referred to our department complaining of gradual visual deterioration in both eyes. Medical history was unremarkable apart from breast cancer for which she had received tamoxifen for 10 years (mean dosage 20 mg/day). Best corrected visual acuity was 20/400 in her right eye and 20/40 in her left eye. Fundoscopy in both eyes was without any obvious signs of maculopathy. However, Fourier-domain OCT demonstrated bilateral extensive areas of disruption in inner retinal layers without any signs of crystalline retinopathy. Six months after the cessation of tamoxifen, the situation remains unchanged.
  
  
  CONCLUSIONS
  Patients receiving tamoxifen should be monitored with high-resolution OCT for fundoscopically invisible changes in the inner retinal layers, the progression of which may seriously affect the patient's vision and subsequently their quality of life.
authors: Department of Ophthalmology, "G Gennimatas" Hospital of Athens, NHS, University of Athens, Athens, Greece.
authors: Ilias
authors: I
authors: Georgalas
authors: Theodore
authors: T
authors: Paraskevopoulos
authors: Dimitris
authors: D
authors: Papaconstaninou
authors: Dimitiris
authors: D
authors: Brouzas
authors: Chryssanthi
authors: C
authors: Koutsandrea
keywords: OCT; maculopathy
references: Ophthalmic Surg Lasers Imaging. 2010 Mar 09;:1-5
references: 20337363
references: Ophthalmologe. 2010 Aug;107(8):750-2
references: 20393723
references: J Cancer Res Ther. 2010 Jul-Sep;6(3):313-5
references: 21119261
references: Exp Biol Med (Maywood). 2004 Jul;229(7):607-15
references: 15229354
references: Breast Cancer Res Treat. 2006 Sep;99(1):117-8
references: 16541311
references: Ophthalmologica. 2010;224(6):333-40
references: 20453539
references: Cancer. 2006 Feb 1;106(3):505-13
references: 16369994
references: Am J Ophthalmol. 2005 Oct;140(4):757-8
references: 16226541
references: Am J Ophthalmol. 2010 Jan;149(1):18-31
references: 20103039
references: Curr Eye Res. 2011 Oct;36(10):867-85
references: 21819259