title: Nona-copper(II)-containing 18-tungsto-8-arsenate(III) exhibits antitumor activity.
abstract: The nona-Cu(II)-containing tungstoarsenate(III) [H4{Cu(II)9As(III)6O15(H2O)6}(α-As(III)W9O33)2](8-) (1a) has been synthesized and characterized. Polyanion 1a comprises a unique, cylindrical {Cu(II)9As(III)6O15(H2O)6}(6+) cluster, which forms a large central cavity and is capped on either end by an [α-As(III)W9O33](9-) capping group. It exhibits remarkable activity against K562 leukaemia cells, as well as induces HepG2 cell apoptosis and autophagy.
authors: Henan Key Laboratory of Polyoxometalate Chemistry, Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan, China.
authors: Zhen
authors: Z
authors: Zhou
authors: Dongdi
authors: D
authors: Zhang
authors: Lu
authors: L
authors: Yang
authors: Pengtao
authors: P
authors: Ma
authors: Yanan
authors: Y
authors: Si
authors: Ulrich
authors: U
authors: Kortz
authors: Jingyang
authors: J
authors: Niu
authors: Jingping
authors: J
authors: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001149:Arsenates / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D017973:Tungsten Compounds / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D001149:Arsenates; D017973:Tungsten Compounds; C039606:tungstoarsenate; D003300:Copper