title: Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II.
abstract: Ca(2+)/calmodulin dependent protein kinase II (CaMKII) is a broadly distributed metazoan Ser/Thr protein kinase that is important in neuronal and cardiac signaling. CaMKII forms oligomeric assemblies, typically dodecameric, in which the calcium-responsive kinase domains are organized around a central hub. We review the results of crystallographic analyses of CaMKII, including the recently determined structure of a full-length and autoinhibited form of the holoenzyme. These structures, when combined with other data, allow informed speculation about how CaMKII escapes calcium-dependence when calcium spikes exceed threshold frequencies.
authors: Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
authors: Margaret M
authors: MM
authors: Stratton
authors: Luke H
authors: LH
authors: Chao
authors: Howard
authors: H
authors: Schulman
authors: John
authors: J
authors: Kuriyan
mesh_terms: D002118:Calcium / Q000737:chemistry / Q000378:metabolism; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D054730:Protein Interaction Domains and Motifs; D055503:Protein Multimerization
chemical_list: D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D002118:Calcium
references: Leukemia. 2009 Mar;23(3):477-85
references: 19039322
references: Gene. 2003 Dec 11;322:17-31
references: 14644494
references: J Clin Invest. 2009 Jul;119(7):1940-51
references: 19603549
references: J Biol Chem. 2007 Nov 30;282(48):35078-87
references: 17923476
references: FEBS Lett. 2000 Jun 16;475(2):107-10
references: 10858498
references: FEBS J. 2006 Feb;273(4):682-94
references: 16441656
references: Nature. 2009 Mar 19;458(7236):299-304
references: 19295602
references: PLoS Biol. 2010 Jul 27;8(7):e1000426
references: 20668654
references: Structure. 2011 Jan 12;19(1):128-40
references: 21220123
references: Eur J Biochem. 1983 Nov 15;136(3):481-7
references: 6315430
references: Cell. 2005 Dec 2;123(5):849-60
references: 16325579
references: Cell. 2011 Sep 2;146(5):732-45
references: 21884935
references: Cell. 1986 Mar 28;44(6):861-70
references: 3006921
references: Science. 1999 Apr 2;284(5411):162-6
references: 10102820
references: Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6369-74
references: 19339497
references: Nat Rev Neurosci. 2002 Mar;3(3):175-90
references: 11994750
references: Trends Biochem Sci. 1999 Jun;24(6):232-6
references: 10366852
references: Science. 1998 Feb 6;279(5352):870-3
references: 9452388
references: J Cell Biol. 1991 Nov;115(4):1049-60
references: 1659571
references: Structure. 2010 May 12;18(5):571-83
references: 20462491
references: Trends Neurosci. 2012 Oct;35(10):607-18
references: 22717267
references: Neuron. 1994 May;12(5):943-56
references: 8185953
references: Nature. 1998 Oct 29;395(6705):863-9
references: 9804419
references: Circ Res. 2011 Sep 16;109(7):729-38
references: 21835909
references: Science. 1998 Jan 9;279(5348):227-30
references: 9422695
references: Mol Cell. 2003 May;11(5):1241-51
references: 12769848
references: Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5855-60
references: 21427228
references: Epilepsia. 2012 Jun;53 Suppl 1:45-52
references: 22612808
references: Trends Biochem Sci. 1994 Nov;19(11):440-4
references: 7855883
references: Neuropharmacology. 2012 Dec;63(8):1298-307
references: 22947307
references: Nature. 2001 Jun 14;411(6839):801-5
references: 11459059
references: Biochem Biophys Res Commun. 2008 May 2;369(2):519-25
references: 18302935
references: Biochemistry. 1997 Apr 15;36(15):4438-48
references: 9109651
references: J Biol Chem. 1992 Aug 25;267(24):17216-24
references: 1324926
references: J Biol Chem. 1993 Apr 5;268(10):7163-70
references: 8385100
references: Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10512-7
references: 12928489
references: J Biol Chem. 2000 May 12;275(19):14354-9
references: 10799516
references: J Mol Cell Cardiol. 2012 May;52(5):1135-44
references: 22326848
references: Structure. 1995 May 15;3(5):467-82
references: 7663944
references: Biophys J. 2008 Sep;95(5):2139-49
references: 18502812
references: Nat Rev Neurosci. 2012 Feb 15;13(3):169-82
references: 22334212
references: Nat Struct Mol Biol. 2010 Mar;17(3):264-72
references: 20139983
references: Circulation. 2012 Oct 23;126(17):2125-39
references: 23091085
references: J Neurosci. 2001 Sep 1;21(17):6694-705
references: 11517259
references: Nature. 1994 Jun 16;369(6481):581-4
references: 8202162
references: Circ Res. 2010 Apr 2;106(6):1134-44
references: 20056922
references: Science. 1992 Jul 10;257(5067):206-11
references: 1321493
references: J Mol Biol. 2001 Apr 20;308(1):1-8
references: 11302701
references: Eur Biophys J. 2008 Nov;38(1):83-98
references: 18769913
references: J Biol Chem. 2001 Aug 3;276(31):29353-60
references: 11384969
references: Nat Methods. 2012 Oct;9(10):1005-12
references: 22961245
references: Nature. 1996 Apr 18;380(6575):636-9
references: 8602266
references: PLoS One. 2012;7(5):e38209
references: 22666486
references: Proc Natl Acad Sci U S A. 1986 Jun;83(12):4253-7
references: 3012560
references: J Cell Biol. 2012 Sep 17;198(6):1055-73
references: 22965911
references: EMBO J. 1996 Dec 16;15(24):6810-21
references: 9003756
references: J Neurophysiol. 2012 Feb;107(4):1058-66
references: 22114157
references: Cell. 1996 Mar 22;84(6):875-87
references: 8601311
references: Cell. 2008 May 2;133(3):462-74
references: 18455987
references: EMBO J. 2011 Apr 6;30(7):1251-62
references: 21343908
references: Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2342-7
references: 19179290
references: Circ Res. 2012 Jun 8;110(12):1661-77
references: 22679140
references: J Neurosci. 2005 Mar 23;25(12):3107-12
references: 15788767