title: Intracellular infections in Drosophila melanogaster: host defense and mechanisms of pathogenesis.
abstract: The fruit-fly Drosophila melanogaster has emerged as a powerful model to study innate immunity against intracellular pathogens. To combat infection, the fly relies on multiple lines of defense, many of which are shared with mammals and arthropod vectors of human diseases. In addition to conserved immune pathways, the ease of performing sophisticated genetic screens has allowed the identification of novel host immune factors and novel pathogen virulence factors. Recently, some groups have exploited this to simultaneously analyze the host and pathogen genetics of intracellular infection. This review aims to unravel the Drosophila immune response against intracellular pathogens, highlighting recent discoveries.
authors: Centre for Molecular and Cellular Biology of Inflammation and Peter Gorer Department of Immunobiology, King's College London School of Medicine, London SE1 1UL, UK.
authors: Claire B
authors: CB
authors: Péan
authors: Marc S
authors: MS
authors: Dionne
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000276:immunology*; D004331:Drosophila melanogaster / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D042541:Intracellular Space; D010587:Phagocytosis / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: C495717:AvrA protein, Salmonella enterica; D001426:Bacterial Proteins; D029721:Drosophila Proteins; D051192:Receptors, Pattern Recognition; D037521:Virulence Factors; C439909:imd protein, Drosophila
keywords: Drosophila; Intracellular infections