title: [Influence of magnesium supplementation on insulin receptor affinity in erythrocytes of type 2 diabetes rats].
abstract: OBJECTIVE
  To observe the influence of oral magnesium supplementation on insulin receptor affinity in erythrocytes of type 2 diabetes rats.
  
  
  METHODS
  diabetes rats were induced by high-fat-diet and intraperitoneal injection of streptozocin, and divided into 4 groups. Magnesium was supplemented in high-fat-diet at the dose of 2000, 1000, 200 and 0 mg/kg,respectively. Normal control rats were fed with ordinary diet. Rats were killed after four weeks. Erythrocytes insulin receptor number, combination constants, combined capacity, fasting insulin level and fasting glucose levels were measured, and insulin resistance index and insulin sensitivity index were calculated.
  
  
  RESULTS
  High affinity insulin receptor combination constant, combined capacity and receptor number in high dosage group were (1.24 +/- 0.47) x 10(9) L/mol, (1.26 +/- 0.53) x 10(14)/L and 80.23 +/- 0.47 respectively, significantly higher than diabetes control group. Insulin resistance index decreased and insulin sensitivity index increased in high dosage group than diabetes control.
  
  
  CONCLUSIONS
  Magnesium supplementation could improve erythrocyte insulin receptor affinity and improve insulin resistance in type 2 diabetic rats.
authors: Chinese PLA General Hospital, Beijing 100853, China. chinazhongww@yahoo.com.cn
authors: Wenwen
authors: W
authors: Zhong
authors: Fusheng
authors: F
authors: Fang
authors: Xiaoling
authors: X
authors: Cheng
authors: Chunlin
authors: C
authors: Li
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004912:Erythrocytes / Q000378:metabolism*; D007333:Insulin Resistance; D008274:Magnesium / Q000008:administration & dosage*; D008297:Male; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D011972:Receptor, Insulin / Q000187:drug effects / Q000378:metabolism*
chemical_list: D011972:Receptor, Insulin; D008274:Magnesium