title: Plasma NPY concentrations in women with acute ischemic stroke.
abstract: OBJECTIVE
  It has been reported that plasma NPY levels were increased in obesity, type 2 diabetes mellitus and hypertension. The symptoms of metabolic syndrome frequently appear in patients with acute ischemic stroke. The association between plasma NPY levels and metabolic markers in women with acute ischemic stroke was investigated in the current study.
  
  
  METHODS
  Plasma NPY concentrations were determined using radioimmunoassay in 58 women aged 60-85 (mean age: 76.5±0.8) with acute ischemic stroke and in 24 women aged 63-67 (mean age: 65.6±0.6) of the control group. Stroke was defined according to the NIHSS (National Institute of Health Stroke Scale) and was confirmed using CT or MR scan.
  
  
  RESULTS
  The prevalence of type 2 diabetes, hypertension and insulin resistance was higher in the group of patients with stroke. Plasma NPY levels measured during the 1st day and 10 days after the acute phase of stroke were significantly lower (p<0.001) compared to the control group.
  
  
  CONCLUSIONS
  In women with acute ischemic stroke plasma NPY concentrations were decreased in spite of higher frequency of the occurrence of the symptoms of metabolic syndrome.
authors: Department of Neuroendocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland. zncmkp@op.pl
authors: Boguslawa
authors: B
authors: Baranowska
authors: Jan
authors: J
authors: Kochanowski
authors: Mariusz
authors: M
authors: Grudniak
authors: Ewa
authors: E
authors: Wolinska-Witort
authors: Malgorzata
authors: M
authors: Kalisz
authors: Wojciech
authors: W
authors: Bik
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D008875:Middle Aged; D009478:Neuropeptide Y / Q000097:blood*; D009765:Obesity / Q000097:blood; D011863:Radioimmunoassay / Q000379:methods; D020521:Stroke / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D009478:Neuropeptide Y