title: Functional connectivity and brain activation: a synergistic approach.
abstract: Traditional functional magnetic resonance imaging (fMRI) studies exploit endogenous brain activity for mapping brain activation during "periodic" cognitive/emotional challenges or brain functional connectivity during the "resting state". Previous studies demonstrated that these approaches provide a limited view of brain function which can be complemented by each other. We hypothesized that graph theory functional connectivity density (FCD) mapping would demonstrate regional FCD decreases between resting-state scan and a continuous "task-state" scan. Forty-five healthy volunteers underwent functional connectivity MRI during resting-state as well as a continuous visual attention task, and standard fMRI with a blocked version of the visual attention task. High-resolution data-driven FCD mapping was used to measure task-related connectivity changes without a priori hypotheses. Results demonstrate that task performance was associated with FCD decreases in brain regions weakly activated/deactivated by the task. Furthermore, a pronounced negative correlation between blood oxygen level-dependent-fMRI activation and task-related FCD decreases emerged across brain regions that also suggest the disconnection of task-irrelevant networks during task performance. The correlation between improved accuracy and stronger FCD decreases further suggests the disconnection of task-irrelevant networks during task performance. Functional connectivity can potentiate traditional fMRI studies and offer a more complete picture of brain function.
authors: National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
authors: Dardo
authors: D
authors: Tomasi
authors: Department of Biosciences, Laboratory of Neuroimaging (LNI/NIAAA), Brookhaven National Laboratory, Upton, NY, USA.
authors: Ruiliang
authors: R
authors: Wang
authors: Department of Biosciences, Laboratory of Neuroimaging (LNI/NIAAA), Brookhaven National Laboratory, Upton, NY, USA Department of Radiology, Stony Brook University, Stony Brook, NY, USA and.
authors: Gene-Jack
authors: GJ
authors: Wang
authors: National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA National Institute on Drug Abuse, Bethesda, MD, USA.
authors: Nora D
authors: ND
authors: Volkow
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012815:Signal Processing, Computer-Assisted; D014796:Visual Perception / Q000502:physiology
keywords: FCD; attention; fMRI; hub; performance
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