title: Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population.
abstract: OBJECTIVE
  Recent genome-wide association studies have indicated 3 new susceptibility loci for Alzheimer disease (AD): complement receptor 1 (CR1), clusterin (CLU), and the phosphatidylinositol-binding clathrin assembly protein (PICALM). We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population.
  
  
  METHODS
  In 253 Caucasian AD patients and 240 controls, analyses identifying the rs6656401, rs3851179 and rs11136000 SNPs and APOE common polymorphisms were performed.
  
  
  RESULTS
  No significant differences were observed in the distribution of the rs6656401 of CR1, rs3851179 of PICALM and rs11136000 of CLU SNPs between AD patients and controls. The APOE ε4 common polymorphism was strongly re-lated to the risk of AD.
  
  
  CONCLUSIONS
  Our results suggest that investigated SNPs are not associated with AD in a Polish population.
authors: Department of Neurology, University Hospital, Jagiellonian University College of Medicine, Botaniczna 3, 31-503 Krakow, Poland. Aleksandra.Klimkowicz@mp.pl
authors: Aleksandra
authors: A
authors: Klimkowicz-Mrowiec
authors: Małgorzata
authors: M
authors: Sado
authors: Anna
authors: A
authors: Dziubek
authors: Tomasz
authors: T
authors: Dziedzic
authors: Joanna
authors: J
authors: Pera
authors: Andrzej
authors: A
authors: Szczudlik
authors: Agnieszka
authors: A
authors: Slowik
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D051152:Clusterin / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D034041:Monomeric Clathrin Assembly Proteins / Q000235:genetics*; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics*
chemical_list: D051152:Clusterin; D034041:Monomeric Clathrin Assembly Proteins; C439003:PICALM protein, human