title: Novel compound, (2Z,6E)-1-hydroxy-3,7-dimethyl-2,6-octadien-8-oic acid produced from biotransformation of nerol by Spodoptera litura larvae.
abstract: Biotransformation of nerol by larvae of the common cutworm (Spodoptera litura) was investigated. The resulting major metabolites were (2Z,6E)-1-hydroxy-3,7-dimethyl-2,6-octadien-8-oic acid and 8-hydroxynerol, and the minor metabolites were 9-hydroxynerol and (2Z,6E)-1-hydroxy-3,7-dimethyl-2,6-octadien-8-al. (2Z,6E)-1-Hydroxy-3,7-dimethyl-2,6-octadien-8-oic acid is a novel compound. The results indicate that biotransformation of nerol by S. litura larvae involved 2 pathways; the main pathway involved oxidation at the methyl group of the geminal dimethyl at C-8 position followed by carboxylation, and the minor pathway involved oxidation at the methyl group of the geminal dimethyl at C-9 position.
authors: Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Osaka, Japan.
authors: Toshirou
authors: T
authors: Ono
authors: Satoshi
authors: S
authors: Koutari
authors: Shinsuke
authors: S
authors: Marumoto
authors: Mitsuo
authors: M
authors: Miyazawa
mesh_terms: D000080462:Acyclic Monoterpenes; D000818:Animals; D007814:Larva / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D018411:Spodoptera / Q000378:metabolism*; D013729:Terpenes / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D000080462:Acyclic Monoterpenes; D013729:Terpenes; C007836:geraniol