title: [Improved methods for researching isolated carotid sinus baroreceptors automatically controlling for sinus pressure].
abstract: OBJECTIVE
  To develop a system for automatically controlling carotid sinus pressure in the study on baroreceptors.
  
  
  METHODS
  The preparation containing carotid sinus with parts of the connected vessels and carotid sinus nerve (CS-CSN) were isolated and perfused. A critical pressure controlling component (PRE-U, Hoerbiger, Deutschland) dictated by a computer was integrated into the system to clamp the intrasinus pressure. The pressure command and the relevant intrasinus pressure were compared to evaluate the validity of the pressure controlling system.
  
  
  RESULTS
  A variety of sinus pressure-controlling patterns, including pulsation, ramp and step pressures, could be achieved accurately by using the system, and the pressure-dependent discharge activities of sinus nerve were confirmed.
  
  
  CONCLUSIONS
  This system for clamping carotid sinus pressure could realize multiple pressure-controlling patterns and is a useful and flexible pressure controlling method that could applied in the study on mechano-electric transduction of baroreceptors.
authors: Medical Experiment and Test Center, Capital Medical University, Beijing 100069, China.
authors: Hua
authors: H
authors: Wei
authors: Hai-Yan
authors: HY
authors: Zhao
authors: Ping
authors: P
authors: Liu
authors: Hai-Xia
authors: HX
authors: Huang
authors: Wei
authors: W
authors: Wang
authors: Xiao-Suo
authors: XS
authors: Fu
authors: Wei-Zhen
authors: WZ
authors: Niu
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002346:Carotid Sinus / Q000294:innervation* / Q000502:physiology*; D009412:Nerve Fibers / Q000502:physiology*; D011311:Pressoreceptors / Q000502:physiology*; D011817:Rabbits