title: Inulin-based glycopolymer: its preparation, lectin-affinity and gellation property.
abstract: The glycopolymer composed of an inulin scaffold and pendent β-lactosides was developed from commercially available inulin through sequential chemical modification processes composed of tosylation, azidation, and the subsequent Huisgen cyclocoupling with an alkyne-terminated β-lactoside. The resultant inulin-based glycopolymer has unique dual affinity towards β-galactoside and α-glucoside specific lectins which is attributable to its pendent β-lactosides and terminal α-glucoside. Its gellation property was also accessed to find that the inulin-based glycopolymer forms hydrogels whose critical gellation concentration (CGC) was lower than that required for hydrogels made from native inulin. Drug release properties of the inulin-based glycopolymer were also discussed in this paper.
authors: Graduate School of Life Sciences, Toyo University, 1-1-1 Izumino, Itakura-machi, Ora-gun 374-0193, Japan.
authors: Kazumi
authors: K
authors: Izawa
authors: Kento
authors: K
authors: Akiyama
authors: Haruka
authors: H
authors: Abe
authors: Yosuke
authors: Y
authors: Togashi
authors: Teruaki
authors: T
authors: Hasegawa
mesh_terms: D000480:Alkynes / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D016650:Fluorescein-5-isothiocyanate; D005456:Fluorescent Dyes; D005697:Galactosides / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D007444:Inulin / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D037102:Lectins / Q000737:chemistry*; D012431:Rutin / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D014105:Tosyl Compounds / Q000737:chemistry
chemical_list: D000480:Alkynes; D004337:Drug Carriers; D005456:Fluorescent Dyes; D005697:Galactosides; D020100:Hydrogels; D037102:Lectins; D014105:Tosyl Compounds; C007816:beta-galactoside; C025506:4-toluenesulfonyl chloride; D012431:Rutin; D007444:Inulin; D016650:Fluorescein-5-isothiocyanate