title: The influence of the Val158Met catechol-O-methyltransferase polymorphism on the personality traits of bipolar patients.
abstract: BACKGROUND
  Certain personality traits and genetic polymorphisms are contributing factors to bipolar disorder and its symptomatology, and in turn, this syndrome influences personality. The aim of the present study is to compare the personality traits of euthymic bipolar patients with healthy controls and to investigate the effect of the catechol-O-methyltransferase (COMT) Val158Met genotype on those traits. We recruited thirty seven bipolar I patients in euthymic state following a manic episode and thirty healthy controls and evaluated their personality by means of the Cloninger's Temperament and Character Inventory (version TCI-R-140). We assessed the influence of the polymorphism Val158Met in the COMT gene on the personality of these patients. The patients scored higher than controls in harm avoidance (61.3±12.5 vs. 55.3±8.1) and self-transcendence (45.3±12.8 vs. 32.7±8.2) and scored lower than controls in self-directedness (68.8±13.3 vs. 79.3±8.1), cooperativeness (77.1±9.1 vs. 83.9±6.5) and persistence (60.4±15.1 vs. 67.1±8.9). The novelty seeking dimension associates with the Val158Met COMT genotype; patients with the low catabolic activity genotype, Met/Met, show a higher score than those with the high catabolic activity genotype, Val/Val.
  
  
  CONCLUSIONS
  Suffering from bipolar disorder could have an impact on personality. A greater value in harm avoidance may be a genetic marker for a vulnerability to the development of a psychiatric disorder, but not bipolar disorder particularly, while a low value in persistence may characterize affective disorders or a subgroup of bipolar patients. The association between novelty seeking scores and COMT genotype may be linked with the role dopamine plays in the brain's reward circuits.
authors: AMSA, Bilbao, Spain.
authors: Wendy
authors: W
authors: Dávila
authors: Nieves
authors: N
authors: Basterreche
authors: Aurora
authors: A
authors: Arrue
authors: María I
authors: MI
authors: Zamalloa
authors: Estíbaliz
authors: E
authors: Gordo
authors: Ricardo
authors: R
authors: Dávila
authors: Miguel A
authors: MA
authors: González-Torres
authors: Mercedes
authors: M
authors: Zumárraga
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology*; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010551:Personality / Q000235:genetics*; D011110:Polymorphism, Genetic; D019655:Quantitative Trait, Heritable; D055815:Young Adult
chemical_list: D002394:Catechol O-Methyltransferase
references: Depress Res Treat. 2011;2011:529638
references: 21789279
references: Psychiatr Genet. 2003 Mar;13(1):33-41
references: 12605099
references: Neurosci Lett. 2006 Jun 19;401(1-2):154-8
references: 16584839
references: Am J Med Genet B Neuropsychiatr Genet. 2008 Apr 5;147(3):326-32
references: 18081158
references: Schizophr Res. 2002 Jul 1;56(1-2):137-47
references: 12084428
references: Psychiatry Res. 2010 May 30;177(3):364-6
references: 20399505
references: Br J Soc Clin Psychol. 1967 Dec;6(4):278-96
references: 6080235
references: Psychopathology. 2009;42(5):337-42
references: 19672137
references: Compr Psychiatry. 2012 Feb;53(2):152-66
references: 21565334
references: J Psychiatr Res. 2008 Jun;42(7):569-77
references: 17675066
references: Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3870-5
references: 20133675
references: J Affect Disord. 2005 Mar;85(1-2):153-68
references: 15780686
references: Compr Psychiatry. 2010 Nov-Dec;51(6):607-17
references: 20965308
references: Genes Brain Behav. 2009 Feb;8(1):5-12
references: 18721261
references: Proc Natl Acad Sci U S A. 2003 May 13;100(10):6186-91
references: 12716966
references: Schizophr Bull. 2007 May;33(3):703-14
references: 17478437
references: J Nerv Ment Dis. 2009 Jul;197(7):514-9
references: 19597359
references: Genes Brain Behav. 2008 Nov;7(8):869-76
references: 18826446
references: Compr Psychiatry. 2007 Sep-Oct;48(5):446-51
references: 17707253
references: Neuro Endocrinol Lett. 2006 Dec;27(6):799-802
references: 17187009
references: Curr Psychiatry Rep. 2010 Dec;12(6):505-11
references: 20878275
references: Psychiatry Res. 1995 Sep 29;58(2):139-43
references: 8570765
references: Auton Neurosci. 2004 Nov 30;116(1-2):1-10
references: 15556832
references: Neuropsychopharmacology. 2004 Nov;29(11):1943-61
references: 15305167
references: J Affect Disord. 2002 Sep;71(1-3):113-20
references: 12167507
references: Br J Psychiatry. 1978 Nov;133:429-35
references: 728692
references: Neurosci Biobehav Rev. 2010 Apr;34(5):689-700
references: 19559045
references: J Affect Disord. 2004 Oct 1;82(1):131-4
references: 15465586
references: Pharmacogenetics. 1996 Jun;6(3):243-50
references: 8807664
references: Brain Res. 2010 Jan 11;1307:142-8
references: 19852950
references: Am J Med Genet. 2000 Jun 12;96(3):360-4
references: 10898915
references: Arch Gen Psychiatry. 1993 Dec;50(12):975-90
references: 8250684
references: Arch Gen Psychiatry. 1992 Aug;49(8):624-9
references: 1637252
references: J Psychiatr Res. 2008 Oct;42(13):1131-6
references: 18191148
references: Eur Psychiatry. 2009 Oct;24(7):476-82
references: 19699061
references: J Affect Disord. 2002 Jul;70(2):219-23
references: 12117635
references: Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6917-22
references: 11381111
references: J Affect Disord. 2005 Mar;85(1-2):207-15
references: 15780691
references: Neuropsychobiology. 2004;50(2):153-6
references: 15292670
references: Mol Psychiatry. 2000 Jan;5(1):96-100
references: 10673775
references: J Psychiatr Res. 1999 Jan-Feb;33(1):31-6
references: 10094237
references: Eur Psychiatry. 2007 Oct;22(7):462-5
references: 17761405
references: J Affect Disord. 2010 Sep;125(1-3):341-4
references: 20122740
references: Biol Psychiatry. 2005 May 15;57(10):1117-27
references: 15866551
references: J Affect Disord. 1999 Apr;53(1):87-90
references: 10363670
references: Neuropsychobiology. 2008;58(3-4):111-7
references: 18997477
references: Psychiatry Res. 2008 Aug 15;160(2):175-83
references: 18602163
references: Eur Psychiatry. 2010 Jan;25(1):26-32
references: 19932601
references: Mol Psychiatry. 2003 Apr;8(4):371-2
references: 12740593
references: Neurosci Lett. 2007 Nov 20;428(1):17-20
references: 17945417
references: Psychol Med. 2011 Aug;41(8):1579-91
references: 21223625
references: Biol Psychiatry. 1999 Aug 15;46(4):557-67
references: 10459407
references: Compr Psychiatry. 2008 Sep-Oct;49(5):503-7
references: 18702937
references: Compr Psychiatry. 2010 Sep-Oct;51(5):510-5
references: 20728009
references: Behav Brain Funct. 2007 Jan 11;3:3
references: 17217544
references: J Psychiatr Res. 1996 Sep-Oct;30(5):353-7
references: 8923339
references: Neurosci Behav Physiol. 2007 Jul;37(6):601-6
references: 17657431