title: Plasma levels of interleukin 18, interleukin 10, and matrix metalloproteinase-9 and -137G/C polymorphism of interleukin 18 are associated with incidence of in-stent restenosis after percutaneous coronary intervention.
abstract: This study aims to investigate the relationship between the levels of IL-18, IL-10, and MMP-9 and -137G/C polymorphism of interleukin 18 with the risk of in-stent restenosis (ISR). The study population consisted of 68 patients with ISR, 173 in non-ISR group, treated with drug-eluting stent and evaluated by coronary angiography post-procedure and at follow-up, and also 109 without angiographic evidence of coronary artery disease (CAD) which formed a reference control group (non-CAD group). The sequential plasma IL-18, IL-10, and MMP-9 levels were assessed at admission, 24 h, and 2 weeks after percutaneous coronary intervention. The -137G/C polymorphism of IL-18 was genotyped by the ligase detection reaction-polymerase chain reaction. Plasma IL-18 and MMP-9 increased significantly from admission, peaking after 24 h and fall after 2 weeks. Compared with the non-ISR group, the ISR group had higher levels of IL-18 and MMP-9, but IL-10 level was the opposite. The -137GG genotype of IL-18 was significantly higher than of the CG and CC genotypes. A significant higher frequency of -137G allele or GG genotype of IL-18 was observed in patients with ISR group compared with the non-ISR group. There is correlation between the changes of IL-18, IL-10, MMP-9, and ISR. IL-18 promoter -137G/C polymorphism influences IL-18 levels and the susceptibility to ISR, suggesting that IL-18-mediated pathways are causally involved in the process of ISR.
authors: Department of Cardiology, Hospital Affiliated to Hubei University of Arts and Science, Jingzhou street 39, Xiangyang, 441021, People's Republic of China, liuwenwei@medmail.com.cn.
authors: Wenwei
authors: W
authors: Liu
authors: Yongsheng
authors: Y
authors: Liu
authors: Hua
authors: H
authors: Jiang
authors: Xiangwu
authors: X
authors: Ding
authors: Rui
authors: R
authors: Zhu
authors: Bin
authors: B
authors: Li
authors: Yuqin
authors: Y
authors: Zhao
mesh_terms: D015984:Causality; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000601:surgery; D005260:Female; D006083:Graft Occlusion, Vascular / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D016753:Interleukin-10 / Q000097:blood*; D020382:Interleukin-18 / Q000097:blood* / Q000235:genetics; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D015607:Stents
chemical_list: C508609:IL10 protein, human; D020382:Interleukin-18; D016753:Interleukin-10; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
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