title: The potential and promise of mefenamic acid.
abstract: Clinical use of mefenamic acid has generally declined in an era where other NSAID use has flourished. While having modes of action and general toxicities similar to other NSAIDs, mefenamic acid, as a member of the fenamates, nevertheless possesses some unique in vitro effects that have the potential to distinguish this agent from others. Use of this drug remains relevant for pain syndromes and some gynecological disorders, albeit with considerable competition from other NSAIDs. New basic science has considerably improved the understanding of the biochemistry of mefenamic acid. As well as maintaining its use in traditional settings, there is a tremendous potential for expanding the application of mefenamic acid to niche roles.
authors: Department of Pathology and Laboratory Medicine, Children's and Women's Health Centre of British Columbia, Vancouver, BC, V6H 3V4, Canada. ncimolai@mail.ubc.ca
authors: Nevio
authors: N
authors: Cimolai
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D054361:Fenamates / Q000494:pharmacology; D006801:Humans; D008528:Mefenamic Acid / Q000737:chemistry / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D054361:Fenamates; D008528:Mefenamic Acid