title: Percutaneous autonomic neural modulation: a novel technique to treat cardiac arrhythmia.
abstract: Ablation and anti-arrhythmic medications have shown promise but have been met with varying success and unwanted side effects such as myocardial injury, arrhythmias, and morbidity from invasive surgical intervention. The answer to improving efficacy of ablation may include modulation of the cardiac aspect of the autonomic nervous system. Our lab has developed a novel approach and device to navigate the oblique sinus and to use DC current and saline/alcohol irrigation to selectively stimulate and block the autonomic ganglia found on the epicardial side of the heart. This novel approach minimizes myocardial damage from thermal injury and provides a less invasive and targeted approach. For feasibility, proof-of-concept, and safety monitoring, we carried out canine studies to test this novel application. Our results suggest a safer and less invasive way of modulating arrhythmogenic substrate that may lead to improved treatment of AF in humans.
authors: Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
authors: Christopher V
authors: CV
authors: DeSimone
authors: Malini
authors: M
authors: Madhavan
authors: Kalpathi L
authors: KL
authors: Venkatachalam
authors: Mark B
authors: MB
authors: Knudson
authors: Samuel J
authors: SJ
authors: Asirvatham
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D004195:Disease Models, Animal; D004285:Dogs; D004599:Electric Stimulation Therapy / Q000379:methods*; D005240:Feasibility Studies; D005725:Ganglia, Autonomic / Q000503:physiopathology*; D006321:Heart / Q000294:innervation*