title: The impact of age and clinical factors in non-muscle-invasive bladder cancer treated with Bacillus Calmette Guerin therapy.
abstract: BACKGROUND
  Bladder cancer is a disease of older persons, the incidence of which is expected to increase as the population ages. Prognostic factors for local recurrence for patients with non-muscle invasive bladder cancer have not been fully established. The aim of our study was to determine the influence of age on the outcomes of non muscle invasive bladder (NMIBC) cancer treated with intravesical Bacillus Calmette-Guerin (BCG) therapy.
  
  
  METHODS
  We retrospectively reviewed the clinical and pathologic data of primary NMIBC from 112 patients who were treated with transurethral resection followed by BCG-immunotherapy. Time follow-up was 30 months. Clinicopathologic characteristics and response to BCG therapy were correlated with age using univariate and multivariate methods of analysis.
  
  
  RESULTS
  Univariate analysis showed that age analyzed as a categorical variable was not associated with other clinicopathological characteristics. On the other hand, multivariate analysis showed that only multiplicity, stage and tumor size were independent significant prognosticators.
  
  
  CONCLUSIONS
  The results of our study have shown that aging has no impact on the outcomes of high-risk NMIBC treated by BCG immunotherapy.
authors: Laboratory of Human and Experimental Pathology, Pasteur Institute of Tunis, Tunis, Tunisia. Faouziaagili@yahoo.fr
authors: Faouzia
authors: F
authors: Ajili
authors: Amine
authors: A
authors: Darouiche
authors: Mouhamed
authors: M
authors: Chebil
authors: Samir
authors: S
authors: Boubaker
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001500:BCG Vaccine / Q000008:administration & dosage*; D001706:Biopsy; D015653:Cystectomy / Q000379:methods; D004724:Endoscopy; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*
chemical_list: D001500:BCG Vaccine