title: Endoscopic in vivo cellular imaging of superficial squamous cell carcinoma of the head and neck by using an integrated endocytoscopy system (with video).
abstract: BACKGROUND
  Recently, some patients have been found to have superficial squamous cell carcinoma (SCC) of the head and neck region during GI endoscopy; however, endoscopic biopsy from a lesion in the head and neck region is troublesome. An endocytoscopy system has been reported to enable optical biopsy of an esophageal lesion.
  
  
  OBJECTIVE
  To evaluate the feasibility of in vivo cellular imaging with an integrated endocytoscopy system for patients with superficial SCC of the head and neck.
  
  
  METHODS
  Experimental pilot study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  This study involved 12 patients who were found to have superficial SCC of the head and neck during GI endoscopy.
  
  
  METHODS
  Endocytoscopic images were taken of each lesion and of the surrounding mucosa. The images were later reviewed by 1 pathologist and 2 endoscopists who were unaware of any other findings.
  
  
  METHODS
  Correlation between endocytoscopy diagnosis and histologic diagnosis.
  
  
  RESULTS
  Adequate endocytoscopic images could be obtained in 11 of the 12 patients (15 of 16 lesions). For endocytoscopic images of 15 lesions and 12 areas of surrounding mucosa, the overall accuracy of endocytoscopic diagnosis in differentiating between nonmalignant and malignant histopathology by the pathologist, endoscopist 1, and endoscopist 2 were 96%, 96%, and 96%, respectively. The kappa value for interobserver agreement was 0.77.
  
  
  CONCLUSIONS
  Single-center experience, small number of patients.
  
  
  CONCLUSIONS
  An endocytoscopy system has the potential to be used as an optical biopsy for superficial head and neck lesions.
authors: Department of Gastroenterology, Hokkaido University Hospital, Sapporo, Japan.
authors: Yuichi
authors: Y
authors: Shimizu
authors: Masakazu
authors: M
authors: Takahashi
authors: Takeshi
authors: T
authors: Yoshida
authors: Shouko
authors: S
authors: Ono
authors: Katsuhiro
authors: K
authors: Mabe
authors: Mototsugu
authors: M
authors: Kato
authors: Masahiro
authors: M
authors: Asaka
authors: Kanako
authors: K
authors: Hatanaka
authors: Naoya
authors: N
authors: Sakamoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D004825:Epiglottis / Q000473:pathology; D004945:Esophagoscopy / Q000379:methods*; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology; D008297:Male; D018715:Microscopy, Video / Q000379:methods*; D008875:Middle Aged; D010157:Palatal Neoplasms / Q000473:pathology; D010610:Pharyngeal Neoplasms / Q000473:pathology; D010865:Pilot Projects; D056144:Pyriform Sinus / Q000473:pathology; D000077195:Squamous Cell Carcinoma of Head and Neck
keywords: APC; ECA; NBI; SCC; argon plasma coagulation; endocytoscopic atypia; narrow-band imaging; squamous cell carcinoma