title: Aspirin desensitization in aspirin-exacerbated respiratory disease.
abstract: Although aspirin desensitization was discovered in 1922, it was not until 1979 that a therapeutic use for aspirin treatment, under the protection of desensitization, was discovered. In the last 33 years, details of aspirin treatment have been refined to the point where it is now recognized and accepted as a major therapeutic intervention in the treatment of aspirin-exacerbated respiratory disease, with therapeutic efficacy in approximately two-thirds of patients. It is only effective in patients who have aspirin-exacerbated respiratory disease and none of the other nonsteroidal anti-inflammatory drugs, despite their cross-reactive inhibition of cyclooxygenase-1, can effectively take the place of aspirin.
authors: Division of Allergy and Immunology, The Scripps Research Institute, Scripps Clinic, San Diego, CA 92130, USA. White.Andrew@scrippshealth.org
authors: Andrew A
authors: AA
authors: White
authors: Donald D
authors: DD
authors: Stevenson
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects / Q000266:history; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects / Q000266:history; D003888:Desensitization, Immunologic / Q000266:history; D004342:Drug Hypersensitivity / Q000188:drug therapy; D049673:History, 20th Century; D006801:Humans; D012140:Respiratory Tract Diseases / Q000139:chemically induced / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin