title: Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis-infected pediatric patients: A single blind, randomized controlled trial.
abstract: OBJECTIVE
  To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion.
  
  
  METHODS
  A single blind, randomized, controlled, pilot clinical study was performed in three government institutions to investigate clinical efficacy of T. cordifolia lotion in sixty-six clinically-diagnosed scabies-infected patients. The patients were treated with T. cordifolia or permethrin lotions for three consecutive days for two weeks and clinical assessment of each patient was performed for five weeks.
  
  
  RESULTS
  T. cordifolia lotion and permethrin significantly reduced the mean global evaluation score after four weeks of treatment. The two lotions showed comparable effects as anti-scabies agent. Moreover, the clearance time (days) and cure rate using the two lotions did not differ. Clinical improvement, mean clearance time and cure rate of T. cordifolia lotion are comparable with permethrin.
  
  
  CONCLUSIONS
  Tinospora cordifolia lotion exhibits anti-scabies activity comparable with permethrin. Its incorporation as therapeutic reagent in Sarcoptes scabiei infections is highly recommended.
authors: Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines.
authors: Agnes L
authors: AL
authors: Castillo
authors: Marina O
authors: MO
authors: Osi
authors: John Donnie A
authors: JD
authors: Ramos
authors: Jean L
authors: JL
authors: De Francia
authors: Marylaine U
authors: MU
authors: Dujunco
authors: Peter F
authors: PF
authors: Quilala
keywords: Anti-scabies; Sarcoptes scabiei; Tinospora cordifolia; scabies
references: J Hosp Infect. 2007 Jan;65(1):9-14
references: 17141368
references: Cancer Lett. 2004 Jan 20;203(2):127-37
references: 14732220
references: Eur J Pharmacol. 2008 Jul 7;588(2-3):141-50
references: 18513715
references: Int J Immunopharmacol. 1996 Oct;18(10):553-61
references: 9080249
references: J Ethnopharmacol. 2004 Jan;90(1):49-55
references: 14698508
references: Phytochemistry. 1999 Nov;52(6):1089-93
references: 10643671
references: Planta Med. 1995 Feb;61(1):98-9
references: 7701011
references: J Ethnopharmacol. 1995 Jan;45(1):43-52
references: 7739226
references: J Ethnopharmacol. 1999 Jan;64(1):53-7
references: 10075122
references: Fitoterapia. 2010 Sep;81(6):485-9
references: 20080155
references: Phytochemistry. 2004 Jul;65(14):2051-5
references: 15279971
references: Int Immunopharmacol. 2007 Oct;7(10):1375-86
references: 17673153
references: J Radiat Res. 2004 Mar;45(1):61-8
references: 15133291
references: Planta Med. 1983 Aug;48(8):275-9
references: 17404996
references: Life Sci. 2002 Dec 27;72(6):645-57
references: 12467905
references: Fitoterapia. 2011 Oct;82(7):976-82
references: 21641970
references: Behav Res Methods. 2007 May;39(2):175-91
references: 17695343
references: Clin Dermatol. 2006 May-Jun;24(3):168-75
references: 16714197
references: Arch Dermatol. 1999 Jun;135(6):651-5
references: 10376691
references: Lancet. 2006 May 27;367(9524):1767-74
references: 16731272
references: J Toxicol Sci. 2002 Aug;27(3):139-46
references: 12238138