title: [Research of postoperative quality of life of laryngeal carcinoma patients].
abstract: OBJECTIVE
  To explore and compare the effect of clinical characters on quality of life (QOL) of laryngeal carcinoma postoperative patients.
  
  
  METHODS
  We performed a retrospective cohort follow up study of 303 patients who underwent operation for laryngeal carcinoma. The Chinese version of the general and the head and neck specific quality of life questionnaires of the European Organization for the Research and Treatment of Cancer (EORTC QLQ-C30 and EORTC QLQ-H&H35) were used to measure the quality of life of those patients in the cohort, to study the relationship between QOL and clinical factors.
  
  
  RESULTS
  In the 303 cases, there were 78 cases retaining the permanent tracheostomies (59 total laryngectomy and 19 partial laryngectomy); 4 patient retain the nasal feed pipe. Female patients were worse than male patients in the domain of physical function and global QOL (P<0.05). Older patients were worse than younger patients in the domain of physical function and speech (P<0.05). Patients with glottic tumors experience better global QOL than their peers with under glottic or supraglottic tumors. The patients with supraglottic tumor have more problem with swallowings (P<0.05). Earlier stage patients have better suitation in many domains than later stage patients, but III stage have more difficulty with swallowing than IV stage. Patients who accepted minimally invasive operation and laryngofissure have better QOL than those accepted partial laryngectomy or total laryngectomy; total laryngectomee have more problems with physical, emotion function, global QOL, sense, speech, cough and morbid feeling than patients with partial laryngectomy, but less problem with fatigue, pain, dyspnea, swollowing and dry mouth; Patients with partial horizontal laryngectomy have more difficulty with swallowing. In the multivariable analysis, the operation mode was an independent factor to speech problem. Patients who accepted neck dissction have more negative outcomes than patients without neck dissection. In the univariable analysis, the permanent tracheostomy was a notable factor which affected many domains in the quality of life; multivariable analysis showed that permanent tracheostomy was an important factor which worked on global quality of life.
  
  
  CONCLUSIONS
  The quality of life was affected by many clinical factors. The operation mode was an independent factor which affect speech problem. Decannulation after partial laryngectomy was very important to keep the quality of life.
authors: Department of Otolaryngology-Head and Neck Surgery, Chinese PLA General Hospital, Beijing, 100853, China.
authors: Yueying
authors: Y
authors: Ma
authors: Liangfa
authors: L
authors: Liu
authors: Deliang
authors: D
authors: Huang
authors: Jialing
authors: J
authors: Wang
authors: Wenming
authors: W
authors: Wu
authors: Mingbo
authors: M
authors: Liu
authors: Jiandong
authors: J
authors: Zhao
mesh_terms: D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000523:psychology* / Q000601:surgery; D007825:Laryngectomy / Q000523:psychology*; D008297:Male; D011184:Postoperative Period; D011788:Quality of Life; D012189:Retrospective Studies; D011795:Surveys and Questionnaires