title: Association of CTLA-4 polymorphisms with improved overall survival in melanoma patients treated with CTLA-4 blockade: a pilot study.
abstract: CTLA-4 blockade with monoclonal antibodies can lead to cancer regression in patients with metastatic melanoma (MM). CTLA-4 gene polymorphisms may influence the response to anti-CTLA-4 antibodies although few data are available regarding this issue. We analyzed six CTLA-4 single nucleotide polymorphisms (-1661A > G, -1577G > A, -658C > T, -319C > T, +49A > G, and CT60G > A) in 14 Italian MM patients and 45 healthy subjects. We found a significant association between the -1577G/A and CT60G/A genotypes and improved overall survival (Pc < 0.006, Bonferroni corrected), further confirmed by the diplotype analysis (-1577 & CT60 GG-AA diplotype, p < 0.001). A positive trend toward an association between these genotypes and response to therapy was also observed.
authors: UOC Oncologia Medica A, IRCCS A.O.U. San Martino-IST, Genova, Italy.
authors: P
authors: P
authors: Queirolo
authors: A
authors: A
authors: Morabito
authors: S
authors: S
authors: Laurent
authors: S
authors: S
authors: Lastraioli
authors: P
authors: P
authors: Piccioli
authors: P A
authors: PA
authors: Ascierto
authors: G
authors: G
authors: Gentilcore
authors: M
authors: M
authors: Serra
authors: A
authors: A
authors: Marasco
authors: E
authors: E
authors: Tornari
authors: B
authors: B
authors: Dozin
authors: M P
authors: MP
authors: Pistillo
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015551:Autoimmunity; D001483:Base Sequence; D060908:CTLA-4 Antigen / Q000037:antagonists & inhibitors / Q000235:genetics*; D016022:Case-Control Studies; D017322:Clinical Trials, Phase II as Topic; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D000074324:Ipilimumab; D053208:Kaplan-Meier Estimate; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality / Q000556:secondary; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D060908:CTLA-4 Antigen; D000074324:Ipilimumab