title: Relationship between impaired cardiac sympathetic activity and spatial dyssynchrony in patients with non-ischemic heart failure: assessment by MIBG scintigraphy and tagged MRI.
abstract: BACKGROUND
  Impairment of cardiac sympathetic activity has various detrimental effects on cardiac function. The purpose was to investigate the relationship between left ventricular (LV) dyssynchrony and cardiac sympathetic activity in non-ischemic heart failure (HF).
  
  
  METHODS
  Twenty-seven patients with non-ischemic HF were enrolled. Cardiac sympathetic activity was assessed by heart-to-mediastinum ratio (H/M ratio) on (123)I-Metaiodobenzylguanidine scintigraphy. LV dyssynchrony was assessed by cross-correlation analysis of time curves of myocardial circumferential strains delivered from cine-tagging MR images. Temporal dyssynchrony was defined as contraction delay between septal and lateral segments >110 milliseconds. Spatial dyssynchrony was defined as the negative value of the maximum correlation for the two strain time curves.
  
  
  RESULTS
  H/M ratio was significantly lower for patients with spatial dyssynchrony compared to patients without (1.8 ± 0.3 vs 2.1 ± 0.3, P < .05). There was no difference between patients with and without temporal dyssynchrony (2.0 ± 0.2 vs 2.0 ± 0.3). The incidence of spatial dyssynchrony was significantly higher in patients with H/M ratio <2.0 than those whose ratios were ≥2.0 (75% vs 20%, P = .001). There was no difference in the incidence of temporal dyssynchrony between the two groups (17% vs 20%).
  
  
  CONCLUSIONS
  Impairment of cardiac sympathetic activity was found to be associated with spatial dyssynchrony in patients with non-ischemic HF.
authors: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Masato
authors: M
authors: Yonezawa
authors: Michinobu
authors: M
authors: Nagao
authors: Koichiro
authors: K
authors: Abe
authors: Yoshio
authors: Y
authors: Matsuo
authors: Shingo
authors: S
authors: Baba
authors: Takeshi
authors: T
authors: Kamitani
authors: Takuro
authors: T
authors: Isoda
authors: Yasuhiro
authors: Y
authors: Maruoka
authors: Mikako
authors: M
authors: Jinnouchi
authors: Yuzo
authors: Y
authors: Yamasaki
authors: Kohtaro
authors: K
authors: Abe
authors: Taiki
authors: T
authors: Higo
authors: Takashi
authors: T
authors: Yoshiura
authors: Hiroshi
authors: H
authors: Honda
mesh_terms: D019797:3-Iodobenzylguanidine; D000293:Adolescent; D000328:Adult; D000368:Aged; D058406:Cardiac Resynchronization Therapy; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006353:Heart-Assist Devices; D006801:Humans; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013564:Sympathetic Nervous System / Q000473:pathology*; D013997:Time Factors; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine
references: J Am Coll Cardiol. 1988 Nov;12(5):1252-8
references: 3170968
references: Circulation. 2011 Dec 13;124(24):2761-96
references: 22068435
references: J Nucl Med. 1989 Jul;30(7):1182-91
references: 2661758
references: J Am Soc Echocardiogr. 2007 Dec;20(12):1330-1337.e1
references: 17643956
references: Hypertension. 2004 Jul;44(1):48-54
references: 15173125
references: J Am Coll Cardiol. 2010 May 18;55(20):2212-21
references: 20188504
references: J Am Coll Cardiol. 2005 Dec 20;46(12):2223-8
references: 16360050
references: J Nucl Cardiol. 1998 Nov-Dec;5(6):579-90
references: 9869480
references: J Nucl Med. 1999 Feb;40(2):224-31
references: 10025827
references: Pacing Clin Electrophysiol. 2005 Oct;28(10):1013-7
references: 16221256
references: N Engl J Med. 1991 Aug 29;325(9):656-7
references: 1861701
references: Eur Respir J. 2009 Dec;34(6):1219-63
references: 19749199
references: Eur J Nucl Med Mol Imaging. 2008 Nov;35(11):2074-81
references: 18682936
references: N Engl J Med. 2002 Jun 13;346(24):1845-53
references: 12063368
references: IEEE Trans Med Imaging. 2010 May;29(5):1114-23
references: 20335094
references: J Am Coll Cardiol. 2004 Nov 2;44(9):1834-40
references: 15519016
references: Int J Cardiol. 2002 Dec;86(2-3):225-31
references: 12419560
references: Circulation. 1990 Aug;82(2 Suppl):I103-13
references: 1973640
references: N Engl J Med. 1985 Jan 31;312(5):277-83
references: 2857050
references: J Am Coll Cardiol. 1995 Jan;25(1):146-53
references: 7798493
references: Eur Heart J. 2011 Jan;32(1):93-103
references: 20971745
references: Phys Med Biol. 2000 Jun;45(6):1665-82
references: 10870717
references: J Am Coll Cardiol. 2002 Nov 6;40(9):1615-22
references: 12427414
references: Circ J. 2012;76(2):382-9
references: 22130315
references: Eur J Nucl Med Mol Imaging. 2008 Mar;35(3):535-46
references: 18043919
references: J Nucl Med. 2010 Aug;51(8):1241-9
references: 20679471
references: J Cardiovasc Magn Reson. 2012 Feb 02;14:14
references: 22300290
references: J Nucl Cardiol. 2007 Sep-Oct;14(5):729-44
references: 17826327
references: Circ J. 2006 Jun;70(6):703-9
references: 16723791
references: Eur Radiol. 2010 May;20(5):1139-48
references: 19915846
references: J Nucl Cardiol. 2007 Nov-Dec;14(6):852-9
references: 18022112
references: Eur Heart J. 1999 Jan;20(2):93-102
references: 10099905
references: J Nucl Med. 1983 Dec;24(12):1194-6
references: 6644382
references: Am J Cardiol. 1992 Jun 1;69(17):1458-66
references: 1590237
references: J Nucl Med. 1999 Jun;40(6):917-23
references: 10452306