title: Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study.
abstract: BACKGROUND
  The interplay between genetic susceptibility and carcinogenic exposure is important in the development of haematopoietic malignancies. EPHX1, NQO1 and PON1 are three genes encoding proteins directly involved in the detoxification of potential carcinogens.
  
  
  METHODS
  We have studied the prevalence of three functional polymorphisms affecting these genes rs1051740 EPHX1, rs1800566 NQO1 and rs662 PON1 in 215 patients with lymphoma and 214 healthy controls.
  
  
  RESULTS
  Genotype frequencies for EPHX and NQO1 polymorphisms did not show any correlation with disease. In contrast, the GG genotype in the PON1 polymorphism was found to be strongly associated with the disease (15.3% vs. 4.7%; OR = 3.7 CI (95%): 1.8-7.7; p < 0.001). According to the pathological diagnosis this association was related to follicular (p = 0.004) and diffuse large B-cell (p = 0.016) lymphomas.
  
  
  CONCLUSIONS
  Despite the fact that further confirmation is needed, this study shows that the PON1 GG genotype in rs662 polymorphism could be a risk factor for B-cell lymphomas.
authors: Pathology Department, Santa Lucía General University Hospital (HGUSL), 30202, Cartagena, Spain. pablo.conesa@carm.es
authors: Pablo
authors: P
authors: Conesa-Zamora
authors: Javier
authors: J
authors: Ruiz-Cosano
authors: Daniel
authors: D
authors: Torres-Moreno
authors: Ignacio
authors: I
authors: Español
authors: María D
authors: MD
authors: Gutiérrez-Meca
authors: Javier
authors: J
authors: Trujillo-Santos
authors: Elena
authors: E
authors: Pérez-Ceballos
authors: Rocío
authors: R
authors: González-Conejero
authors: Javier
authors: J
authors: Corral
authors: Vicente
authors: V
authors: Vicente
authors: Miguel
authors: M
authors: Pérez-Guillermo
mesh_terms: D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase / Q000235:genetics*; D016022:Case-Control Studies; D016001:Confidence Intervals; D004851:Epoxide Hydrolases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008223:Lymphoma / Q000235:genetics*; D008224:Lymphoma, Follicular / Q000235:genetics; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics; D008297:Male; D008875:Middle Aged; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; D004851:Epoxide Hydrolases; C522330:EPHX1 protein, human
references: Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1647-53
references: 16985026
references: Cancer Res. 1997 Jul 15;57(14):2839-42
references: 9230185
references: Hum Mol Genet. 2001 Jun 1;10(12):1265-73
references: 11406608
references: Chem Biol Interact. 2005 May 30;153-154:33-41
references: 15935798
references: J Lipid Res. 2005 Jun;46(6):1239-47
references: 15772423
references: Am J Epidemiol. 2005 Nov 1;162(9):849-57
references: 16177143
references: Haematologica. 2007 Nov;92(11):1581-2
references: 18024413
references: Mol Carcinog. 2012 Jun;51(6):508-13
references: 21681823
references: Am J Epidemiol. 2007 Jun 1;165(11):1248-54
references: 17332311
references: Nat Genet. 2009 Aug;41(8):873-5
references: 19620980
references: Cancer Res. 2004 Mar 15;64(6):2264-9
references: 15026372
references: Leuk Res. 2009 Jul;33(7):898-901
references: 19162321
references: Int J Cancer. 2002 Jan 10;97(2):230-6
references: 11774269
references: Chem Biol Interact. 2005 May 30;153-154:231-7
references: 15885679
references: Cancer Causes Control. 2005 Jun;16(5):599-607
references: 15986116
references: Occup Environ Med. 2005 Mar;62(3):195-9
references: 15723885
references: BMC Public Health. 2007 Mar 21;7:40
references: 17376231
references: Environ Mol Mutagen. 2010 Jan;51(1):48-56
references: 19593802
references: Nat Genet. 1993 Jan;3(1):73-6
references: 8098250
references: Cell Res. 2009 Apr;19(4):519-23
references: 19290020
references: PLoS Genet. 2011 Apr;7(4):e1001378
references: 21533074
references: Nat Genet. 2010 Aug;42(8):661-4
references: 20639881
references: Environ Mol Mutagen. 2012 Oct;53(8):619-30
references: 22930568
references: Haematologica. 2005 Nov;90(11):1511-5
references: 16266898
references: Arch Toxicol. 2012 Mar;86(3):431-9
references: 21983886
references: Environ Sci Pollut Res Int. 2009 Mar;16(2):152-61
references: 19104864
references: Toxicology. 2013 May 10;307:12-6
references: 22800774
references: PLoS Genet. 2013;9(1):e1003220
references: 23349640
references: Drug Metab Pharmacokinet. 2006 Aug;21(4):257-76
references: 16946553
references: Hum Mol Genet. 1994 Mar;3(3):421-8
references: 7516776
references: Hematol Oncol. 2011 Sep;29(3):116-23
references: 20824655
references: BMC Public Health. 2006 Jan 27;6:17
references: 16438735
references: Epidemiology. 1999 Sep;10(5):481-7
references: 10468419
references: Am J Epidemiol. 2008 Dec 1;168(11):1221-32
references: 18945694
references: Am J Epidemiol. 2011 Feb 15;173(4):404-13
references: 21228414
references: Br J Haematol. 2002 Aug;118(2):477-81
references: 12139735
references: Pediatr Blood Cancer. 2004 Oct;43(5):568-70
references: 15382274
references: Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8150-5
references: 10393963