title: Extensive diversification is a common feature of Pseudomonas aeruginosa populations during respiratory infections in cystic fibrosis.
abstract: BACKGROUND
  Populations of the Liverpool Epidemic Strain (LES) of Pseudomonas aeruginosa undergo extensive diversification in the cystic fibrosis (CF) lung during long-term chronic infections.
  
  
  METHODS
  We analyzed sets of 40 isolates from the sputa of five CF patients, each chronically infected with a different non-LES strain of P. aeruginosa. For each sample (two per patient), diversity was assessed by characterizing nine phenotypic traits.
  
  
  RESULTS
  All P. aeruginosa populations were highly diverse, with the majority of phenotypic variation being due to within-sample diversity.
  
  
  CONCLUSIONS
  Maintenance of diverse populations in the CF lung is a common feature of P. aeruginosa infections.
authors: Regional Adult Cystic Fibrosis Unit, Liverpool Heart and Chest Hospital, Liverpool L14 3PE, United Kingdom.
authors: Abdul
authors: A
authors: Ashish
authors: Steve
authors: S
authors: Paterson
authors: Eilidh
authors: E
authors: Mowat
authors: Joanne L
authors: JL
authors: Fothergill
authors: Martin J
authors: MJ
authors: Walshaw
authors: Craig
authors: C
authors: Winstanley
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000382:microbiology*; D005260:Female; D006801:Humans; D008168:Lung / Q000382:microbiology*; D008297:Male; D010641:Phenotype; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000145:classification*; D013183:Sputum / Q000382:microbiology; D055815:Young Adult
keywords: Cystic fibrosis; Population biology; Pseudomonas aeruginosa
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