title: Determination of phthalates released from paper packaging materials by solid-phase extraction-high-performance liquid chromatography.
abstract: A solid phase extraction (SPE) high-performance liquid chromatography (HPLC) method was developed for the simultaneous determination of 10 phthalic acid esters (dimethyl phthalate, diethyl phthalate, dipropyl phthalate, benzylbutyl phthalate, diisobutyl phthalate, dicyclohexyl phthalate, diamyl phthalate, di-n-hexyl phthalate, di-n-octyl phthalate and di-2-ethylhexyl phthalate) released from food paper packaging materials. The use of distilled water, 3% acetic acid (w/v), 10% ethanol (v/v) and 95% ethanol (v/v) instead of the different types of food simulated the migration of 10 phthalic acid esters from food paper packaging materials; the phthalic acid esters in four food simulants were enriched and purified by a C18 SPE column and nitrogen blowing, and quantified by HPLC with a diode array detector. The chromatographic conditions and extraction conditions were optimized and all 10 of the phthalate acid esters had a maximum absorbance at 224 nm. The method showed limitations of detection in the range of 6.0-23.8 ng/mL the correlation coefficients were greater than 0.9999 in all cases, recovery values ranged between 71.27 and 106.97% at spiking levels of 30, 60 and 90 ng/mL and relative standard deviation values ranged from 0.86 to 8.00%. The method was considered to be simple, fast and reliable for a study on the migration of these 10 phthalic acid esters from food paper packaging materials into food.
authors: 1College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao 266003, China.
authors: Xin
authors: X
authors: Gao
authors: Bofeng
authors: B
authors: Yang
authors: Zhixu
authors: Z
authors: Tang
authors: Xin
authors: X
authors: Luo
authors: Fengmei
authors: F
authors: Wang
authors: Hui
authors: H
authors: Xu
authors: Xue
authors: X
authors: Cai
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000592:standards; D018857:Food Packaging; D006801:Humans; D057230:Limit of Detection; D010209:Paper; D010795:Phthalic Acids / Q000032:analysis / Q000302:isolation & purification*; D012015:Reference Standards; D052616:Solid Phase Extraction / Q000592:standards
chemical_list: D010795:Phthalic Acids