title: Genomic diversity of Bombyx mori nucleopolyhedrovirus strains.
abstract: Bombyx mori nucleopolyhedrovirus (BmNPV) is a baculovirus that selectively infects the domestic silkworm. In this study, six BmNPV strains were compared at the whole genome level. We found that the number of bro genes and the composition of the homologous regions (hrs) are the two primary areas of divergence within these genomes. When we compared the ORFs of these BmNPV variants, we noticed a high degree of sequence divergence in the ORFs that are not baculovirus core genes. This result is consistent with the results derived from phylogenetic trees and evolutionary pressure analyses of these ORFs, indicating that ORFs that are not core genes likely play important roles in the evolution of BmNPV strains. The evolutionary relationships of these BmNPV strains might be explained by their geographic origins or those of their hosts. In addition, the total number of hr palindromes seems to affect viral DNA replication in Bm5 cells.
authors: Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou 310018, China.
authors: Yi-Peng
authors: YP
authors: Xu
authors: Ruo-Lin
authors: RL
authors: Cheng
authors: Yu
authors: Y
authors: Xi
authors: Chuan-Xi
authors: CX
authors: Zhang
mesh_terms: D000818:Animals; D012831:Bombyx / Q000235:genetics* / Q000821:virology; D014644:Genetic Variation; D016679:Genome, Viral; D055029:Inverted Repeat Sequences / Q000235:genetics; D017924:Nucleopolyhedroviruses / Q000235:genetics*; D016366:Open Reading Frames / Q000235:genetics; D010802:Phylogeny; D012689:Sequence Homology, Nucleic Acid; D014764:Viral Proteins / Q000235:genetics*; D014779:Virus Replication / Q000235:genetics
chemical_list: D014764:Viral Proteins