title: Losartan supports liver regrowth via distinct boost of portal vein pressure in rodents with 90 % portal branch ligation.
abstract: OBJECTIVE
  The study used a model of 90 % portal branch ligation (PBL) in rats to study the effect of losartan on portal vein pressure (PVP) and liver regeneration in rats after PBL.
  
  
  METHODS
  A total of 144 male Sprague-Dawley rats were arbitrarily designated into three treatment method groups: a sham operation group (Sham), a PBL treatment group (PBL), and a PBL plus losartan treatment group (PBL + L). Losartan (2 mg/day) was intragastrically gavaged 3 days before the PBL or sham operation to time points of study.
  
  
  RESULTS
  Both the PBL and PBL + L groups showed an intense surge in PVP after PBL treatment, peaking at 12 h postsurgery, then lessening progressively afterwards. PVP was substantially greater in these two groups compared with the Sham group at 6-72 h postsurgery (p < 0.01). Compared with the PBL group, the PBL + L group showed a noticeable reduction in PVP 6-48 h postsurgery (p < 0.05); the PBL group showed considerably raised levels of plasma ALT and AST 6-72 h postsurgery (p < 0.01). Compared to the PBL group, the PBL + L group showed drastically reduced plasma ALT and AST levels 12-72 h postsurgery (p < 0.05).
  
  
  CONCLUSIONS
  Losartan supports liver regeneration in 90 % of rats that underwent PBL. The mechanism may be related to losartan's ability to regulate PVP and increase serum hepatocyte growth factor levels.
authors: Department of Hepatobiliopancreatic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
authors: Kezhou
authors: K
authors: Li
authors: Xiaohong
authors: X
authors: Qi
authors: Jiaying
authors: J
authors: Yang
authors: Jianping
authors: J
authors: Gong
authors: Chunlu
authors: C
authors: Tan
authors: Qingjie
authors: Q
authors: Xia
authors: Jieran
authors: J
authors: Long
authors: Zhongdin
authors: Z
authors: Wang
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects; D008026:Ligation; D008099:Liver / Q000098:blood supply / Q000473:pathology; D008115:Liver Regeneration / Q000187:drug effects*; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D011169:Portal Vein / Q000187:drug effects* / Q000502:physiology / Q000601:surgery; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D018809:Proliferating Cell Nuclear Antigen; D019808:Losartan
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