title: Identification of blaOXA-₅₁-like, blaOXA-₅₈, blaDIM-₁, and blaVIM carbapenemase genes in hospital Enterobacteriaceae isolates from Sierra Leone.
abstract: We describe the results of a molecular epidemiological survey of 15 carbapenemase-encoding genes from a recent collection of clinical isolates from Mercy Hospital in Bo, Sierra Leone. The most salient findings revealed that (i) 60% of the isolates harbored multiple carbapenemase genes; (ii) the blaDIM-1 gene, which has previously only been reported in The Netherlands, is also circulating in this environment; and (iii) blaOXA-51-like and blaOXA-58 genes, which were thought to reside exclusively in Acinetobacter species, can also be found in members of the Enterobacteriaceae.
authors: Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, District of Columbia, USA.
authors: Tomasz A
authors: TA
authors: Leski
authors: Umaru
authors: U
authors: Bangura
authors: David H
authors: DH
authors: Jimmy
authors: Rashid
authors: R
authors: Ansumana
authors: Stephen E
authors: SE
authors: Lizewski
authors: Robert W
authors: RW
authors: Li
authors: David A
authors: DA
authors: Stenger
authors: Chris R
authors: CR
authors: Taitt
authors: Gary J
authors: GJ
authors: Vora
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology*; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D012807:Sierra Leone / Q000453:epidemiology; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase
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