title: A new chromosome translocation t(7;16)(q31,q22) change during an acute promyelocytic leukemia relapse.
abstract: The translocation t(15;17), which results in the PML-RARα fusion gene, is a characteristic chromosomal translocation in acute promyelocytic leukemia (APL). But additional chromosome aberrations in APL are increasingly recognized. Here, we report on a 16-year-old APL patient who had an fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) and a 46,XY,t(15;17)(q22;q21)-16+mar karyotype at diagnosis. The patient achieved complete remission after induction therapy with all-trans retinoic acid and chemotherapy. But he soon relapsed presenting distinctive APL features in the bone marrow and leptomeninges and showing a chromosome translocation change involving chromosomes 7 and 16 besides t(15;17)(q22;q21). The new karyotype 46,XY,t(7;16)(q31;q22),t(15;17)(q22;q21) was determined. To the best of our knowledge, this is the first report of a de novo APL with a chromosome translocation t(7;16)(q31,q22) together with a t(15;17)(q22;q21) and FLT3-ITD mutation.
authors: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
authors: Y
authors: Y
authors: Cao
authors: R
authors: R
authors: Yuan
authors: Y
authors: Y
authors: Wang
authors: R
authors: R
authors: Chen
authors: M
authors: M
authors: Huang
authors: J
authors: J
authors: Zhou
mesh_terms: D059786:Abnormal Karyotype; D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D009154:Mutation; D011859:Radiography; D012008:Recurrence; D014178:Translocation, Genetic; D014212:Tretinoin / Q000627:therapeutic use; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics
chemical_list: D014212:Tretinoin; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3