title: Longitudinal comparison of quality of life after real-time tumor-tracking intensity-modulated radiation therapy and radical prostatectomy in patients with localized prostate cancer.
abstract: The purpose of this study was to compare the quality of life (QOL) in patients with localized prostate cancer (PC) after intensity-modulated radiation therapy assisted with a fluoroscopic real-time intensity-modulated radiation therapy (RT-IMRT) tumor-tracking system versus the QOL after radical prostatectomy (RP). Between 2003 and 2006, 71 patients were enrolled in this longitudinal prospective study. Each patient was allowed to decide which treatment modality they would receive. Of the 71 patients, 23 patients underwent RT-IMRT, while 48 opted for RP. No patient received neo-adjuvant or adjuvant hormone therapy. The global QOL and disease-specific-QOL were evaluated before treatment and again at 1, 3 and 5 years after treatment. There was no significant difference in the background characteristics between the two groups. The 5-year biochemical progression-free survival was 90% in the RT-IMRT and 79% in the RP group. In the RT-IMRT group, there was no significant deterioration of the global QOL or disease-specific QOL through 5 years post-treatment. In the RP group, the urinary function, sexual function, and sexual bother indicators significantly deteriorated after treatment. Urinary and sexual function was significantly better in the RT-IMRT group at 1, 3 and 5 years post-treatment compared to the RP group. RT-IMRT may be a preferable treatment for localized PC because of similar efficacy to RP but better post-treatment QOL.
authors: Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, North-15, West-7, Kitaku, Sapporo 060-8638, Japan.
authors: Nobuo
authors: N
authors: Shinohara
authors: Satoru
authors: S
authors: Maruyama
authors: Shinichi
authors: S
authors: Shimizu
authors: Kentaro
authors: K
authors: Nishioka
authors: Takashige
authors: T
authors: Abe
authors: Kanako
authors: K
authors: C-Hatanaka
authors: Koji
authors: K
authors: Oba
authors: Katsuya
authors: K
authors: Nonomura
authors: Hiroki
authors: H
authors: Shirato
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy / Q000401:mortality; D003199:Computer Systems; D018572:Disease-Free Survival; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction / Q000706:statistics & numerical data*; D015995:Prevalence; D011468:Prostatectomy / Q000401:mortality*; D011471:Prostatic Neoplasms / Q000401:mortality* / Q000628:therapy*; D011788:Quality of Life; D020266:Radiotherapy, Conformal / Q000379:methods / Q000401:mortality*; D061089:Radiotherapy, Image-Guided / Q000401:mortality*; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome
keywords: QOL; image-guided radiotherapy; intensity-modulated radiation; radical prostatectomy; real-time tumor-tracking
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