title: Prognostic value of serum resistin levels in patients with acute myocardial infarction.
abstract: BACKGROUND
  Resistin is a novel adipokine that is suggested to be involved in inflammatory conditions and atherosclerosis.
  
  
  OBJECTIVE
  To investigate the prognostic importance of resistin in acute myocardial infarction (AMI) patients.
  
  
  METHODS
  Resistin levels were measured in a population of 132 patients with AMI, of whom 72 (54%) had a diagnosis of ST elevation myocardial infarction (STEMI), and 60 (46%) had non-ST elevation myocardial infarction (NSTEMI). Thirty-three consecutive subjects who were referred to elective coronary angiography due to chest pain evaluation with normal coronary angiograms served as controls. All patients were followed-up for the occurrence of major adverse cardiac events (MACE).
  
  
  RESULTS
  There was a significant increase in serum resistin levels in patients with AMI compared to controls (3.71 ± 4.20 vs. 2.00 ± 1.05, p = 0.001, respectively). However, serum resistin levels were similar in patients with STEMI and NSTEMI. (4.26 ± 5.11 vs. 3.06 ± 2.64, p = 0.49, respectively). The patients with MACE had significantly higher levels of serum resistin levels compared to either the AMI or the control group (6.35 ± 5.47, p = 0.005, respectively). Logistic regression analysis revealed that resistin, left ventricular ejection fraction, and coronary artery bypass graft were independent predictors of MACE in AMI patients (OR = 1.11, 95% CI 1.01-1.22, p = 0.03 and OR = 3.84, 95% CI 1.26-11.71, p = 0.018, respectively).
  
  
  CONCLUSIONS
  Serum resistin level was increased in patients with AMI and constituted a risk factor for MACE in this group.
authors: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Centre, Istanbul, Turkey. drhberer@yahoo.com.
authors: Hatice Betul
authors: HB
authors: Erer
authors: Nurten
authors: N
authors: Sayar
authors: Tolga Sinan
authors: TS
authors: Guvenc
authors: Sebahat
authors: S
authors: Aksaray
authors: Hale
authors: H
authors: Yilmaz
authors: Servet
authors: S
authors: Altay
authors: Ayca
authors: A
authors: Turer
authors: Tugba Kemaloglu
authors: TK
authors: Oz
authors: Fatma Ozpamuk
authors: FO
authors: Karadeniz
authors: Dilaver
authors: D
authors: Oz
authors: Ahmet
authors: A
authors: Ekmekci
authors: Aycan Esen
authors: AE
authors: Zencirci
authors: Mehmet
authors: M
authors: Eren
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D011379:Prognosis; D052243:Resistin / Q000097:blood*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D052243:Resistin