title: VCAM1 expression correlated with tumorigenesis and poor prognosis in high grade serous ovarian cancer.
abstract: High expression of vascular cell adhesion molecule 1 (VCAM1) has been shown to be associated with several cancers although its role in ovarian cancer development is largely undefined. The purpose of this study is to investigate its role in ovarian cancer using the epithelial cells and ovarian cancer cell lines and correlate its expression with clinicopathologic parameters in ovarian cancer patients. VCAM1 expression was examined via immunohistochemical staining of 251 high grade serous carcinoma samples using tissue microarray. The expression of VCAM1 was silenced in RAS-transformed ovarian epithelial cell lines and two high grade ovarian cancer cell lines. Cell migration was analyzed in vitro and effect on tumor growth was analyzed in nude mice. High VCAM1 expression was found to be was related with response to surgery and chemotherapy drugs (P = 0.025) and elder age at diagnosis (P = 0.008). Cox regression multivariable analysis showed that VCAM1 expression in tumor cells was an independent prognostic factor. Ovarian cancer cells with VCAM1 overexpression, compared with corresponding control cells, had increased cell migration and enhanced growth of xenograft tumors in mice. Our data provide strong evidence that VCAM1 plays an important role in ovarian tumor growth, and it may be used as a prognostic factor and novel therapeutic target for ovarian cancer.
authors: Department of Pathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA ; Department of Pathology, Affiliated Hospital of Nantong University Nantong, Jiangsu, P. R. China.
authors: Jianfei
authors: J
authors: Huang
authors: Jing
authors: J
authors: Zhang
authors: Hongxia
authors: H
authors: Li
authors: Zhaohui
authors: Z
authors: Lu
authors: Weiwei
authors: W
authors: Shan
authors: Imelda
authors: I
authors: Mercado-Uribe
authors: Jinsong
authors: J
authors: Liu
keywords: Ovarian cancer; VCAM1; overall survival; tumor growth
references: Arthritis Rheum. 2001 May;44(5):985-94
references: 11352261
references: Eur J Cancer. 2011 Sep;47 Suppl 3:S104-15
references: 21943964
references: Clin Cancer Res. 2010 Aug 1;16(15):3875-86
references: 20505188
references: J Clin Oncol. 2010 May 1;28(13):2159-66
references: 20368574
references: Clin Cancer Res. 2011 Apr 15;17(8):2181-94
references: 21339307
references: Oncogene. 2005 Sep 8;24(40):6174-84
references: 15940260
references: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references: 21296855
references: Cancer Res. 2009 Feb 15;69(4):1469-76
references: 19208843
references: Leuk Lymphoma. 2012 Jan;53(1):50-6
references: 21895545
references: Nat Rev Cancer. 2011 Sep 23;11(10):719-25
references: 21941283
references: Cancer Sci. 2010 Aug;101(8):1886-90
references: 20491774
references: Clin Cancer Res. 2012 Oct 15;18(20):5806-15
references: 22912389
references: Int Immunopharmacol. 2006 Apr;6(4):672-7
references: 16504931
references: Int J Gynaecol Obstet. 2006 Nov;95 Suppl 1:S193-203
references: 17161158
references: Exp Hematol. 2009 Jan;37(1):19-30
references: 18951693
references: Anticancer Res. 2005 May-Jun;25(3A):1597-601
references: 16033066
references: Thromb Res. 2012 Apr;129(4):e47-50
references: 22209338
references: Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2292-301
references: 17673705
references: Clin Nucl Med. 2011 Oct;36(10):889-93
references: 21892039
references: Cancer Res. 2012 Mar 1;72(5):1064-9
references: 22282663
references: Eur J Cancer. 2005 Oct;41(15):2355-9
references: 16146689
references: J Clin Oncol. 2009 Dec 10;27(35):6006-11
references: 19826110
references: Anticancer Res. 2004 Mar-Apr;24(2C):1243-7
references: 15154654
references: Cancer Cell. 2011 Dec 13;20(6):701-14
references: 22137794
references: Cancer Res. 2004 Mar 1;64(5):1655-63
references: 14996724
references: Clin Cancer Res. 2004 Nov 1;10(21):7252-9
references: 15534099
references: Int J Oncol. 2006 Jan;28(1):77-85
references: 16327982
references: Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16472-7
references: 17060621
references: Clin Cancer Res. 2012 Feb 1;18(3):869-81
references: 22142828
references: Histopathology. 2000 Jul;37(1):78-83
references: 10931222
references: Cancer Res. 2012 Aug 15;72(16):4060-73
references: 22896685
references: J Natl Cancer Inst. 2010 Jun 2;102(11):812-27
references: 20484106