title: Adverse skin effects of imatinib, a tyrosine kinase inhibitor.
abstract: Imatinib mesylate is a tyrosine kinase inhibitor that targets the BCR-ABL, c-kit, and PDGF (platelet-derived growth factor) receptors. Imatinib is mainly indicated for chronic myeloid leukemia and gastrointestinal stromal tumors but is also prescribed by dermatologists for dermatofibrosarcoma protuberans, systemic sclerosis, and systemic mastocytosis, among other conditions. Most adverse effects are mild or moderate and therapy is generally well tolerated. Adverse skin effects are very common and include nonspecific manifestations such as edema and maculopapular rashes or eruptions of diverse types (lichenoid or psoriasiform lesions, acute generalized exanthematic pustulosis, Stevens-Johnson syndrome, and more). Identifying and properly treating these reactions can help optimize adherence to treatment and improve the prognosis of the underlying disease.
authors: Departamento de Dermatología, Clínica Universidad de Navarra, Pamplona, España. Electronic address: mpretel@unav.es.
authors: M
authors: M
authors: Pretel-Irazabal
authors: Departamento de Dermatología, Hospital de Donostia, San Sebastián, España.
authors: A
authors: A
authors: Tuneu-Valls
authors: Departamento de Dermatología, Hospital de Donostia, San Sebastián, España.
authors: N
authors: N
authors: Ormaechea-Pérez
mesh_terms: D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D000068877:Imatinib Mesylate / Q000009:adverse effects*; D011505:Protein-Tyrosine Kinases / Q000009:adverse effects*
chemical_list: D000068877:Imatinib Mesylate; D011505:Protein-Tyrosine Kinases
keywords: Adverse effect; Efecto adverso; Imatinib; Piel; Skin