title: Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2.
abstract: Because stromal cells can regulate the growth and metastasis of tumor cells, a compound that modulates the interaction between the stromal cells and the tumor cells can control the tumor progression. In the course of our screening for such a compound, we have isolated a new compound, intervenolin, from the culture broth of Nocardia sp. ML96-86F2. Intervenolin inhibits the growth of human gastric and colorectal cancer cell lines in the coculture with the respective organ-derived stromal cells more strongly than that of the cancer cells cultured alone. Intervenolin shows antitumor effect against a xenograft model of human colorectal cancer cells in vivo. Furthermore, intervenolin exerts selective anti-Helicobacter pylori effect.
authors: Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu, Shizuoka, Japan.
authors: Manabu
authors: M
authors: Kawada
authors: Hiroyuki
authors: H
authors: Inoue
authors: Shun-Ichi
authors: S
authors: Ohba
authors: Masaki
authors: M
authors: Hatano
authors: Masahide
authors: M
authors: Amemiya
authors: Chigusa
authors: C
authors: Hayashi
authors: Ihomi
authors: I
authors: Usami
authors: Hikaru
authors: H
authors: Abe
authors: Takumi
authors: T
authors: Watanabe
authors: Naoko
authors: N
authors: Kinoshita
authors: Masayuki
authors: M
authors: Igarashi
authors: Tohru
authors: T
authors: Masuda
authors: Daishiro
authors: D
authors: Ikeda
authors: Akio
authors: A
authors: Nomoto
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018920:Coculture Techniques; D015179:Colorectal Neoplasms / Q000188:drug therapy; D004195:Disease Models, Animal; D005260:Female; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000737:chemistry*; D015363:Quinolones / Q000302:isolation & purification / Q000494:pharmacology*; D017154:Stromal Cells / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D015363:Quinolones; C583644:intervenolin