title: Deoxyribonucleic acid damage-associated biomarkers of ionising radiation: current status and future relevance for radiology and radiotherapy.
abstract: Diagnostic and therapeutic radiation technology has developed dramatically in recent years, and its use has increased significantly, bringing clinical benefit. The use of diagnostic radiology has become widespread in modern society, particularly in paediatrics where the clinical benefit needs to be balanced with the risk of leukaemia and brain cancer increasing after exposure to low doses of radiation. With improving long-term survival rates of radiotherapy patients and the ever-increasing use of diagnostic and interventional radiology procedures, concern has risen over the long-term risks and side effects from such treatments. Biomarker development in radiology and radiotherapy has progressed significantly in recent years to investigate the effects of such use and optimise treatment. Recent biomarker development has focused on improving the limitations of established techniques by the use of automation, increasing sensitivity and developing novel biomarkers capable of quicker results. The effect of low-dose exposure (0-100 mGy) used in radiology, which is increasingly linked to cancer incidences, is being investigated, as some recent research challenges the linear-no-threshold model. Radiotherapy biomarkers are focused on identifying radiosensitive patients, determining the treatment-associated risk and allowing for a tailored and more successful treatment of cancer patients. For biomarkers in any of these areas to be successfully developed, stringent criteria must be applied in techniques and analysis of data to reduce variation among reports and allow data sets to be accurately compared. Newly developed biomarkers can then be used in combination with the established techniques to better understand and quantify the individual biological response to exposures associated with radiology tests and to personalise treatment plans for patients.
authors: Biological Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, UK. Grainne.Manning@phe.gov.uk
authors: G
authors: G
authors: Manning
authors: K
authors: K
authors: Rothkamm
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D004247:DNA / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D015870:Gene Expression / Q000528:radiation effects; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000528:radiation effects*; D015162:Micronucleus Tests; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control; D018787:Radiation Oncology; D011839:Radiation, Ionizing; D018570:Risk Assessment
chemical_list: D015415:Biomarkers; D004247:DNA
references: N Engl J Med. 2007 Nov 29;357(22):2277-84
references: 18046031
references: Clin Oncol (R Coll Radiol). 2007 Aug;19(6):397-417
references: 17478086
references: Int J Radiat Biol. 1998 Aug;74(2):207-15
references: 9712549
references: Int J Radiat Biol. 1996 Sep;70(3):301-8
references: 8800201
references: J Clin Oncol. 1999 May;17(5):1339-48
references: 10334517
references: Radiat Oncol. 2011 Jun 07;6:62
references: 21649920
references: Int J Radiat Biol. 2013 Jul;89(7):512-22
references: 23362884
references: Radiat Environ Biophys. 2010 Nov;49(4):685-92
references: 20602108
references: Cancer Res. 2006 Jul 1;66(13):6459-62
references: 16818612
references: Radiat Environ Biophys. 2003 Oct;42(3):175-82
references: 14551783
references: Br J Cancer. 2006 Aug 21;95(4):520-4
references: 16819540
references: Mutat Res. 1999 Sep 15;445(1):105-11
references: 10521696
references: Clin Chem. 2009 Apr;55(4):611-22
references: 19246619
references: PLoS One. 2008 Apr 02;3(4):e1912
references: 18382685
references: Carcinogenesis. 2003 Nov;24(11):1837-45
references: 12951355
references: J Natl Cancer Inst. 1989 Sep 6;81(17):1307-12
references: 2769783
references: Mutagenesis. 2011 Jan;26(1):169-75
references: 21164199
references: Int J Radiat Oncol Biol Phys. 2011 Dec 1;81(5):1465-72
references: 20947264
references: J Pediatr Surg. 2003 Mar;38(3):367-71; discsussion 367-71
references: 12632351
references: Radiat Res. 2009 May;171(5):541-8
references: 19580489
references: Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13761-6
references: 14610281
references: Int J Radiat Biol. 2004 Aug;80(8):559-66
references: 15370967
references: Phys Med Biol. 2009 Oct 21;54(20):6029-39
references: 19779223
references: Cell Cycle. 2011 Apr 1;10(7):1152-61
references: 21389785
references: Radiat Res. 2010 Jan;173(1):71-8
references: 20041761
references: Mutat Res. 2008 Apr 30;652(2):112-21
references: 18337160
references: Int J Radiat Biol. 2007 Oct;83(10):639-52
references: 17729159
references: Radiother Oncol. 2000 May;55(2):173-8
references: 10799729
references: Int J Radiat Oncol Biol Phys. 2010 Oct 1;78(2):359-69
references: 20153123
references: Int J Radiat Oncol Biol Phys. 2006 Mar 15;64(4):1023-30
references: 16446056
references: Int J Radiat Biol. 1992 Jul;62(1):53-63
references: 1353776
references: Radiat Res. 1984 Jul;99(1):140-50
references: 6539927
references: Clin Cancer Res. 2012 Oct 1;18(19):5479-88
references: 22855580
references: Mutagenesis. 2003 Mar;18(2):187-94
references: 12621075
references: Circulation. 2009 Nov 10;120(19):1903-9
references: 19858412
references: Int J Radiat Biol. 2011 Jan;87(1):46-56
references: 21142613
references: Clin Chem. 2003 Sep;49(9):1467-75
references: 12928227
references: N Engl J Med. 1999 Apr 15;340(15):1154-61
references: 10202166
references: Radiother Oncol. 2011 May;99(2):225-30
references: 21620495
references: Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6635-40
references: 15096622
references: Int J Radiat Oncol Biol Phys. 2012 Dec 1;84(5):1078-85
references: 22867894
references: Int J Radiat Oncol Biol Phys. 2001 Feb 1;49(2):547-54
references: 11173153
references: Int J Radiat Biol. 2010 Jan;86(1):2-11
references: 20070210
references: Int J Radiat Oncol Biol Phys. 2007 Jul 15;68(4):1145-50
references: 17418963
references: Br J Cancer. 2008 Jun 3;98(11):1845-51
references: 18493234
references: Int J Cancer. 2011 Dec 15;129(12):2928-34
references: 21491423
references: Lancet Oncol. 2012 Jan;13(1):65-77
references: 22169268
references: Int J Radiat Biol. 1998 Jun;73(6):661-70
references: 9690684
references: Strahlenther Onkol. 2011 Jan;187(1):52-8
references: 21234528
references: Methods Mol Biol. 2005;291:49-57
references: 15502211
references: Nat Rev Cancer. 2009 Feb;9(2):134-42
references: 19148183
references: Radiat Prot Dosimetry. 2011 Nov;147(4):573-92
references: 21183550
references: Radiat Res. 1999 Sep;152(3):225-31
references: 10453082
references: Cell Mol Life Sci. 2005 Jul;62(13):1489-501
references: 15971001
references: Methods. 2010 Apr;50(4):217-26
references: 20025972
references: Nature. 1970 May 23;226(5247):717-22
references: 5443247
references: Radiother Oncol. 2003 Nov;69(2):137-44
references: 14643950
references: Clin Cancer Res. 2008 Oct 15;14(20):6546-55
references: 18927295
references: Radiat Res. 2011 Mar;175(3):282-90
references: 21388271
references: PLoS One. 2011;6(9):e25113
references: 21966430
references: J Radiol Prot. 2003 Dec;23(4):423-30
references: 14750689
references: Curr Biol. 1999 Jul 1;9(13):699-702
references: 10395545
references: PLoS Med. 2006 Oct;3(10):e422
references: 17076557
references: Int J Radiat Biol. 2011 Nov;87(11):1103-12
references: 21797809
references: Oncogene. 1996 Nov 21;13(10):2287-93
references: 8950997
references: Radiat Res. 2003 Mar;159(3):312-9
references: 12600233
references: Radiother Oncol. 2011 Jun;99(3):362-6
references: 21704405
references: Int J Radiat Biol. 1993 Aug;64(2):179-84
references: 8103541
references: Int J Radiat Oncol Biol Phys. 2003 Sep 1;57(1):222-9
references: 12909237
references: Radiat Res. 2008 Sep;170(3):335-44
references: 18763857
references: Int J Radiat Oncol Biol Phys. 2013 Mar 1;85(3):686-92
references: 22795805
references: Radiat Res. 2002 Jan;157(1):99-105
references: 11754647
references: Lancet. 2012 Aug 4;380(9840):499-505
references: 22681860
references: Int J Radiat Oncol Biol Phys. 1996 Dec 1;36(5):1065-75
references: 8985028
references: Int J Radiat Biol. 1999 Apr;75(4):513-7
references: 10331857
references: Nat Genet. 2001 Dec;29(4):365-71
references: 11726920
references: Mutagenesis. 2000 May;15(3):245-9
references: 10792018
references: Health Phys. 2010 Feb;98(2):179-85
references: 20065681
references: Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5057-62
references: 12679524
references: Radiology. 2007 Jan;242(1):244-51
references: 17185671
references: J Radiat Res. 2001 Sep;42 Suppl:S149-55
references: 11791748
references: Clin Cancer Res. 2005 Oct 15;11(20):7426-33
references: 16243816
references: Science. 1999 Oct 15;286(5439):531-7
references: 10521349
references: Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):886-94
references: 20510199
references: Oncol Rep. 2010 Feb;23(2):571-8
references: 20043123
references: PLoS One. 2010 Jul 12;5(7):e11535
references: 20634956
references: Cancer Res. 1997 Oct 15;57(20):4600-7
references: 9377575
references: Int J Radiat Oncol Biol Phys. 1999 Oct 1;45(3):707-14
references: 10524426
references: Radiat Prot Dosimetry. 2005;113(4):396-402
references: 15928034
references: Radiat Res. 2011 May;175(5):631-7
references: 21443424
references: Radiat Res. 2007 Apr;167(4):475-84
references: 17388699
references: Cancer Res. 2008 Jan 15;68(2):605-14
references: 18199558
references: Radiat Res. 2007 Jun;167(6):727-34
references: 17523852
references: Radiat Res. 1991 Feb;125(2):214-22
references: 1996380
references: ScientificWorldJournal. 2006 Sep 25;6:1174-90
references: 17013523
references: J Natl Cancer Inst. 2008 Mar 19;100(6):428-36
references: 18334707
references: PLoS Med. 2007 Apr;4(4):e106
references: 17407386
references: Appl Radiat Isot. 2000 May;52(5):1107-12
references: 10836413
references: Oral Oncol. 2007 Mar;43(3):289-300
references: 16920386
references: Int J Radiat Oncol Biol Phys. 2008 May 1;71(1):256-64
references: 18406889
references: PLoS One. 2012;7(1):e29853
references: 22238667
references: J Biol Chem. 1998 Mar 6;273(10):5858-68
references: 9488723
references: Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8984-9
references: 15956203
references: J Clin Oncol. 2006 Jul 20;24(21):3361-6
references: 16801631
references: Int J Radiat Biol. 2011 Feb;87(2):115-29
references: 21067298
references: Health Phys. 2010 Feb;98(2):234-43
references: 20065688
references: Radiat Res. 2009 Oct;172(4):500-8
references: 19772471
references: Hum Genet. 2008 Jun;123(5):485-93
references: 18437427
references: Cancer Res. 2004 Sep 15;64(18):6368-71
references: 15374940