title: Propofol for adult procedural sedation in a UK emergency department: safety profile in 1008 cases.
abstract: BACKGROUND
  Concerns exist regarding the safe use of propofol by Emergency Physicians for procedural sedation. The World SIVA International Sedation Task Force has recently created an adverse event tool, in an effort to standardize reporting. We present a safety analysis of our use of propofol using this tool.
  
  
  METHODS
  Propofol was given according to a previously published guideline. We analysed our dedicated departmental sedation database between December 2006 and March 2012 and cross-examined the original sedation chart for each case recorded. We stratified the identified adverse events according to consensus agreement.
  
  
  RESULTS
  Of the 1008 consecutive cases, we identified 11 sentinel (5 cases of hypoxia, 6 of hypotension), 34 moderate, 25 minor, and 3 minimal risk adverse events. There were no adverse outcomes.
  
  
  CONCLUSIONS
  Our large series of propofol sedations performed by emergency physicians supports the safety of this practice. The sentinel adverse event rate of 1% that we identify prompts review: we will in future emphasize adherence to the reduced 0.5 mg kg(-1) propofol dose in the elderly, and reconsider our use of metaraminol. We believe that our application of the World SIVA adverse event tool sets a benchmark for further studies.
authors: Emergency Department, Royal Devon & Exeter NHS Foundation Trust, Barrack Road, Exeter EX2 5DW, UK.
authors: B
authors: B
authors: Newstead
authors: S
authors: S
authors: Bradburn
authors: A
authors: A
authors: Appelboam
authors: A
authors: A
authors: Reuben
authors: A
authors: A
authors: Harris
authors: A
authors: A
authors: Hudson
authors: L
authors: L
authors: Jones
authors: C
authors: C
authors: McLauchlan
authors: P
authors: P
authors: Riou
authors: M
authors: M
authors: Jadav
authors: G
authors: G
authors: Lloyd
mesh_terms: D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000369:Aged, 80 and over; D016292:Procedural Sedation / Q000009:adverse effects* / Q000379:methods / Q000592:standards; D004636:Emergency Service, Hospital; D004739:England; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D015742:Propofol / Q000009:adverse effects*; D012189:Retrospective Studies; D018571:Sentinel Surveillance
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol
keywords: anaesthetics i.v.; governance; propofol; sedation