title: A first new antimalarial pregnane glycoside fromGongronema napalense.
abstract: As a part of the UIC-based ICBG project in Laos, plants were collected based on ethnomedical interviews and evaluated for antimalarial activity. A CHCl3extract from the vine ofGongronema napalense(Wall.) Decne. (Asclepiadaceae) showed promising anti-malarial activity while exhibiting low levels of cytotoxicity and was thus followed up with further fractionation and biological evaluation. Bioassay-guided fractionation led to the isolation of a new steroidal glycoside, gongroneside A, which showed antimalarial activityin vitrowith an IC50value of 1.60 and 1.39 μM against thePlasmodium falciparumD6 and W2 clones, respectively.
authors: Program for Collaborative Research in the Pharmaceutical Sciences, M/C 781, Department of Medical Chemistry & Pharmacognosy, College of Pharmacy, the University of Illinois, Chicago, Illinois 60612, USA ; Biology Department, Bradly University, Peoria, IL 61625, USA.
authors: Amey
authors: A
authors: Libman
authors: Hongjie
authors: H
authors: Zhang
authors: Cuiying
authors: C
authors: Ma
authors: Bounhong
authors: B
authors: Southavong
authors: Kongmany
authors: K
authors: Sydara
authors: Somsanith
authors: S
authors: Bouamanivong
authors: Ghee T
authors: GT
authors: Tan
authors: Harry H S
authors: HH
authors: Fong
authors: D Doel
authors: DD
authors: Soejarto
keywords: Gongronema napalense; Plasmodium falciparum; antimalarial activity; asclepiadaceae; gongroneside A; steroid glycoside
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