title: Clinical implications of microRNAs in cancer.
abstract: MicroRNAs (miRNAs) are endogenously produced non-coding RNAs that serve as micromanagers by negatively regulating gene expression. MiRNAs are implicated in several biological pathways including development of neoplasia. Because altered miRNA expression is implicated in the pathobiology of various cancers, these molecules serve as potential therapeutic targets. Using miRNA mimics to restore levels of aberrantly down-regulated miRNAs or miRNA inhibitors to inactivate over-expressed miRNAs shows promise as the next generation of therapeutic strategies. Manipulation of miRNAs offers an alternative therapeutic approach for chemo- and radiation-resistant tumors. Similarly, miRNA expression patterns can be used for diagnosis and to predict prognosis and efficacy of therapy. We present here an overview of how miRNAs affect cancers, how they may be used as biomarkers, and the clinical implications of miRNAs in cancer.
authors: Department of Pathology, University of Alabama at Birmingham , Birmingham.
authors: L C
authors: LC
authors: Bovell
authors: B D K
authors: BD
authors: Putcha
authors: T
authors: T
authors: Samuel
authors: U
authors: U
authors: Manne
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D059467:Transcriptome
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
references: Br J Cancer. 2009 Aug 18;101(4):699-706
references: 19638978
references: Oncologist. 2010;15(7):673-82
references: 20576643
references: J Breast Cancer. 2011 Dec;14(4):269-75
references: 22323912
references: Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13513-8
references: 17686970
references: Carcinogenesis. 2010 Dec;31(12):2049-57
references: 20876285
references: Int J Cancer. 2013 Apr 1;132(7):1602-12
references: 22927033
references: PLoS One. 2013;8(1):e53582
references: 23301089
references: Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13944-9
references: 16166262
references: Nat Rev Drug Discov. 2010 Oct;9(10):775-89
references: 20885409
references: Med Res Rev. 2012 Mar;32(2):326-48
references: 22383180
references: Mol Cell Proteomics. 2002 Nov;1(11):845-67
references: 12488461
references: Cancer Res. 2005 Aug 15;65(16):7065-70
references: 16103053
references: Clin Cancer Res. 2009 Sep 1;15(17):5473-7
references: 19706812
references: Mol Cancer. 2010 Apr 30;9:96
references: 20433742
references: Clin Pharmacol Ther. 2001 Mar;69(3):89-95
references: 11240971
references: J Pathol. 2012 Jul;227(3):306-14
references: 22294324
references: FEBS J. 2009 Nov;276(22):6689-700
references: 19843160
references: Cancer. 1995 Nov 15;76(10 Suppl):1919-27
references: 8634983
references: Ann Surg Oncol. 2012 Sep;19(9):3065-71
references: 22322955
references: Cancer Epidemiol Biomarkers Prev. 2010 Jul;19(7):1766-74
references: 20551304
references: Biochem Biophys Res Commun. 2005 Sep 9;334(4):1351-8
references: 16039986
references: Proteomics. 2009 Mar;9(5):1374-84
references: 19253296
references: Adv Surg. 2011;45:31-44
references: 21954677
references: Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2999-3004
references: 14973191
references: Urol Oncol. 2010 Nov-Dec;28(6):655-61
references: 19375957
references: Colorectal Dis. 2012 Feb;14(2):133-4
references: 22233118
references: Cancer Genomics Proteomics. 2006 Oct;3(5):317-324
references: 18172508
references: Oncotarget. 2012 Feb;3(2):195-202
references: 22350310
references: Mol Cell Biochem. 2013 Mar;375(1-2):23-30
references: 23291979
references: Cancer Cell. 2006 Mar;9(3):189-98
references: 16530703
references: Pharmacogenomics J. 2011 Dec;11(6):429-36
references: 20585341
references: Cell Cycle. 2008 Jun 1;7(11):1545-9
references: 18469529
references: Nucleic Acids Res. 2009 May;37(8):2584-95
references: 19264808
references: Cell. 2007 Mar 23;128(6):1105-18
references: 17382880
references: Cancer Lett. 2013 Feb 28;329(2):125-36
references: 23196059
references: Oral Dis. 2010 Jan;16(1):34-8
references: 19627513
references: Biomark Insights. 2006;2:113-121
references: 18079988
references: Biomark Med. 2010 Oct;4(5):761-70
references: 20945991
references: Gynecol Oncol. 2009 Sep;114(3):457-64
references: 19501389
references: Carcinogenesis. 2000 Mar;21(3):517-24
references: 10688872
references: Oncogene. 2007 Apr 26;26(19):2799-803
references: 17072344
references: Eur J Cancer. 2011 Mar;47(5):784-91
references: 21112772
references: Oncogene. 2009 Nov 19;28(46):4065-74
references: 19734943
references: Clin Cancer Res. 2001 Jul;7(7):1952-6
references: 11448909
references: Int J Cardiol. 2013 Sep 10;167(6):3028-9
references: 23194784
references: Cancer Res. 2008 Apr 15;68(8):2745-54
references: 18417445
references: Cancer Lett. 2011 Jan 28;300(2):197-204
references: 21067862
references: Br J Haematol. 2008 May;141(5):672-5
references: 18318758
references: J Transl Med. 2012 Jun 20;10:128
references: 22716183
references: PLoS One. 2011;6(8):e23271
references: 21876743
references: BioDrugs. 2007;21(2):97-104
references: 17402793
references: Oncology. 2012;82(4):205-12
references: 22456107
references: J Cell Physiol. 2006 Jun;207(3):571-81
references: 16250021
references: Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3687-92
references: 16505370
references: Clin Cancer Res. 2011 Feb 15;17(4):928-36
references: 21149617
references: Mol Biol Rep. 2013 Mar;40(3):2091-6
references: 23212612
references: Oncogene. 2006 Apr 20;25(17):2537-45
references: 16331254
references: PLoS One. 2012;7(2):e31060
references: 22347428
references: PLoS One. 2008;3(12):e4029
references: 19107213
references: BMC Cancer. 2010 Nov 09;10:616
references: 21062447
references: PLoS One. 2012;7(7):e40634
references: 22815777
references: J Am Chem Soc. 2010 Jun 16;132(23):7976-81
references: 20527935
references: Breast Cancer Res. 2009;11(4):R44
references: 19575807
references: JAMA. 2008 Jan 30;299(4):425-36
references: 18230780
references: Nat Med. 2005 Jul;11(7):712-4
references: 16015356
references: Science. 2007 Dec 21;318(5858):1931-4
references: 18048652
references: J Transl Med. 2013 Jan 09;11:10
references: 23302469
references: Drug Discov Today. 2005 Jul 15;10(14):965-76
references: 16023055
references: Biochim Biophys Acta. 2006 Dec;1766(2):184-96
references: 16973289
references: Trends Mol Med. 2006 Dec;12(12):580-7
references: 17071139
references: Dis Markers. 2002;18(2):41-6
references: 12364809
references: J Clin Oncol. 2006 Oct 10;24(29):4677-84
references: 16966691
references: N Engl J Med. 2008 May 1;358(18):1919-28
references: 18450603
references: Gastroenterology. 2006 Jun;130(7):2113-29
references: 16762633
references: Clin Cancer Res. 2008 Dec 15;14(24):8080-6
references: 19088023
references: Cancer Res. 2007 Nov 1;67(21):10117-22
references: 17974952
references: Genes Chromosomes Cancer. 2008 Sep;47(9):794-802
references: 18521848
references: Carcinogenesis. 2012 Jul;33(7):1294-301
references: 22610076
references: Funct Integr Genomics. 2005 Jul;5(3):129-35
references: 15875226
references: Angew Chem Int Ed Engl. 2008;47(39):7482-4
references: 18712719