title: Cryptococcus neoformans constitutes an ideal model organism to unravel the contribution of cellular aging to the virulence of chronic infections.
abstract: Aging affects all organisms, from unicellular yeasts to multicellular humans. Studies in model organisms demonstrate that the pathways that mediate the two forms of aging, replicative and chronological, are highly conserved. Most studies are focused on the effect of aging on an individual cell rather than a whole population. Complex longevity regulation, however, makes aging a highly adaptive trait that is subject to natural selection. Recent studies have shed light on the potential relevance of aging in fungal pathogens, which undergo replicative aging when they expand in the host environment. Hence, pathogens causing chronic infections can constitute ideal model organisms in unraveling the contribution of selection to aging within a population and help elucidate the contribution of aging itself to the virulence of infections.
authors: Department of Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
authors: Tejas
authors: T
authors: Bouklas
authors: Bettina C
authors: BC
authors: Fries
mesh_terms: D016922:Cellular Senescence; D002908:Chronic Disease; D003453:Cryptococcosis / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000472:pathogenicity / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D014774:Virulence
references: PLoS Genet. 2010 Jul 15;6(7):e1001024
references: 20657825
references: Nature. 2010 Mar 25;464(7288):513-9
references: 20336133
references: Microbiology (Reading). 2002 Jan;148(Pt 1):191-201
references: 11782511
references: Eukaryot Cell. 2003 Feb;2(1):49-61
references: 12582122
references: Genes Dev. 1999 Oct 1;13(19):2570-80
references: 10521401
references: Yeast. 1995 Apr 15;11(4):361-9
references: 7785337
references: Antimicrob Agents Chemother. 2001 Nov;45(11):3162-70
references: 11600372
references: Cell Cycle. 2011 Jan 1;10(1):144-55
references: 21248481
references: J Clin Microbiol. 1999 Oct;37(10):3204-9
references: 10488178
references: Infect Immun. 2011 Dec;79(12):4990-5000
references: 21968999
references: J Infect Dis. 2002 Aug 15;186(4):522-30
references: 12195380
references: Science. 2012 Jan 6;335(6064):100-4
references: 22174129
references: Aging Cell. 2008 Oct;7(5):746-57
references: 18691183
references: Science. 2005 Nov 18;310(5751):1193-6
references: 16293764
references: Eukaryot Cell. 2011 Apr;10(4):502-11
references: 21335533
references: Curr Genet. 2004 Nov;46(5):247-55
references: 15503029
references: Cell Cycle. 2011 Jan 1;10(1):156-65
references: 21191185
references: Aging Cell. 2010 Dec;9(6):1084-97
references: 20883526
references: Annu Rev Cell Dev Biol. 2008;24:29-54
references: 18616424
references: Cell Host Microbe. 2010 Jul 22;8(1):86-99
references: 20638645
references: Antimicrob Agents Chemother. 2008 Sep;52(9):3259-66
references: 18625775
references: Cell Death Differ. 2009 Jan;16(1):94-102
references: 19079287
references: Methods Mol Biol. 2007;371:89-95
references: 17634576
references: Eukaryot Cell. 2004 Oct;3(5):1076-87
references: 15470236
references: Exp Gerontol. 2011 Nov;46(11):915-22
references: 21871551
references: J Bacteriol. 1999 Oct;181(20):6339-46
references: 10515923
references: FEBS Lett. 2004 Jan 16;557(1-3):136-42
references: 14741356
references: J Med Microbiol. 2011 Oct;60(Pt 10):1523-1529
references: 21596904
references: Adv Genet. 2007;57:143-73
references: 17352904
references: Eukaryot Cell. 2007 Dec;6(12):2169-74
references: 17951515
references: Autophagy. 2008 Nov;4(8):982-8
references: 18927489
references: Infect Immun. 2000 Jul;68(7):4225-37
references: 10858240
references: Nature. 2002 Jul 18;418(6895):344-8
references: 12124627
references: Exp Gerontol. 2013 Oct;48(10):1006-13
references: 23235143
references: Mech Ageing Dev. 2007 Jan;128(1):106-11
references: 17126379
references: PLoS Genet. 2012 Jul;8(7):e1002810
references: 22792079
references: Eukaryot Cell. 2009 Jun;8(6):858-66
references: 19411622
references: Nature. 1959 Jun 20;183(4677):1751-2
references: 13666896
references: J Cell Biol. 1994 Dec;127(6 Pt 2):1985-93
references: 7806576
references: Exp Gerontol. 2006 Apr;41(4):448-56
references: 16516427
references: Aging Cell. 2007 Oct;6(5):649-62
references: 17711561
references: Lab Invest. 1996 Dec;75(6):759-70
references: 8973471
references: Ann N Y Acad Sci. 2010 Jun;1197:19-27
references: 20536828
references: FEMS Yeast Res. 2007 Sep;7(6):848-59
references: 17506834
references: Microbiology (Reading). 2001 Aug;147(Pt 8):2355-2365
references: 11496012
references: Genetics. 2006 Apr;172(4):2025-32
references: 16636111
references: Aging Cell. 2006 Aug;5(4):345-57
references: 16822282
references: Cell. 1996 Feb 23;84(4):633-42
references: 8598049
references: Neurosurgery. 1986 Mar;18(3):373-5
references: 3517675
references: J Bioenerg Biomembr. 2008 Aug;40(4):381-8
references: 18704665
references: Infect Immun. 2005 Oct;73(10):6350-62
references: 16177306
references: Genetics. 2009 Oct;183(2):413-22, 1SI-13SI
references: 19652178
references: Trends Microbiol. 2004 May;12(5):243-9
references: 15120144
references: PLoS One. 2008;3(11):e3802
references: 19030232
references: Cell. 2005 Nov 18;123(4):655-67
references: 16286010
references: Mech Ageing Dev. 2005 Jan;126(1):17-21
references: 15610758
references: Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9100-5
references: 10430902
references: Cell Microbiol. 2012 Dec;14(12):1819-27
references: 22966777
references: Yeast. 1999 Oct;15(14):1511-8
references: 10514568
references: Aging Cell. 2003 Apr;2(2):73-81
references: 12882320
references: J Clin Invest. 2008 Mar;118(3):1186-97
references: 18259613
references: J Vis Exp. 2009 Jun 25;(28):
references: 19556967