title: Impaired learning resulting from respiratory syncytial virus infection.
abstract: Respiratory syncytial virus (RSV) is the major cause of respiratory illness in infants worldwide. Neurologic alterations, such as seizures and ataxia, have been associated with RSV infection. We demonstrate the presence of RSV proteins and RNA in zones of the brain--such as the hippocampus, ventromedial hypothalamic nucleus, and brainstem--of infected mice. One month after disease resolution, rodents showed behavioral and cognitive impairment in marble burying (MB) and Morris water maze (MWM) tests. Our data indicate that the learning impairment caused by RSV is a result of a deficient induction of long-term potentiation in the hippocampus of infected animals. In addition, immunization with recombinant bacillus Calmette-Guérin (BCG) expressing RSV nucleoprotein prevented behavioral disorders, corroborating the specific effect of RSV infection over the central nervous system. Our findings provide evidence that RSV can spread from the airways to the central nervous system and cause functional alterations to the brain, both of which can be prevented by proper immunization against RSV.
authors: Millenium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331010, Chile.
authors: Janyra A
authors: JA
authors: Espinoza
authors: Karen
authors: K
authors: Bohmwald
authors: Pablo F
authors: PF
authors: Céspedes
authors: Roberto S
authors: RS
authors: Gómez
authors: Sebastián A
authors: SA
authors: Riquelme
authors: Claudia M
authors: CM
authors: Cortés
authors: Javier A
authors: JA
authors: Valenzuela
authors: Rodrigo A
authors: RA
authors: Sandoval
authors: Floria C
authors: FC
authors: Pancetti
authors: Susan M
authors: SM
authors: Bueno
authors: Claudia A
authors: CA
authors: Riedel
authors: Alexis M
authors: AM
authors: Kalergis
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D007859:Learning Disabilities / Q000209:etiology* / Q000517:prevention & control / Q000821:virology; D017774:Long-Term Potentiation / Q000502:physiology; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009163:Mycobacterium bovis / Q000276:immunology; D012367:RNA, Viral / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018357:Respiratory Syncytial Virus Infections / Q000150:complications* / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D014764:Viral Proteins / Q000378:metabolism*; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins; D014765:Viral Vaccines
keywords: LTD; LTP; behavior; cognition; inflammation
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