title: Prothrombotic states in migraine.
abstract: The increased risk of cardiovascular and cerebrovascular events in patients with migraine remains unexplained. Prothrombotic states are thought to contribute to this increased risk. The present study aimed to compare the prevalence of prothrombotic states in patients with migraine and headache-free controls. We conducted a case-control study to screen for prothrombotic states protein C, protein S (PS), antithrombin III, factor V Leiden, lupus anticoagulant, anticardiolipin, and anti-β2-glycoprotein 1 antibodies in 101 consecutive patients with migraine and 148 controls. An underlying prothrombotic state was encountered in 11.8% of the patients with migraine, PS deficiency being the most common (4.0%). There was no significant difference in the prevalence of prothrombotic states in patients with migraine compared to controls. Traditional prothrombotic states do not seem to have a higher prevalence in patients with migraine compared to controls.
authors: Department of Neurology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors: Roopa
authors: R
authors: Rajan
authors: Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors: Jasmina
authors: J
authors: Ahluwalia
authors: Department of Neurology, Postgraduate Institute of Medical Education & Research, Chandigarh, India vivekl44@yahoo.com.
authors: Vivek
authors: V
authors: Lal
mesh_terms: D000293:Adolescent; D000328:Adult; D017153:Antibodies, Anticardiolipin; D000990:Antithrombin III / Q000032:analysis; D001778:Blood Coagulation Disorders / Q000209:etiology; D016022:Case-Control Studies; D005165:Factor V / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000150:complications; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis; D053482:beta 2-Glycoprotein I / Q000276:immunology
chemical_list: D017153:Antibodies, Anticardiolipin; D011486:Protein C; D017293:Protein S; D053482:beta 2-Glycoprotein I; C095381:factor V Leiden; D000990:Antithrombin III; D005165:Factor V
keywords: cardiovascular; cerebrovascular; migraine; prothrombotic states; stroke