title: Individuals' half-lives for 2,3,4,7,8-penta-chlorodibenzofuran (PeCDF) in blood: correlation with clinical manifestations and laboratory results in subjects with Yusho.
abstract: BACKGROUND
  In 1968, many people developed dioxin poisoning (Yusho) in Japan. Ingestion of 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PeCDF) was considered to be the cause of this poisoning. Although some patients had high concentrations of 2,3,4,7,8-PeCDF in their blood, individuals' half-lives of 2,3,4,7,8-PeCDF were long.
  
  
  OBJECTIVE
  To evaluate the relationship between clinical and laboratory parameters and the individual half-life of 2,3,4,7,8-PeCDF in blood.
  
  
  METHODS
  Clinical and laboratory data were collected during annual check-ups from 2001 to 2008. We enrolled 71 patients, who were measured more than 3 times, and who had 2,3,4,7,8-PeCDF concentrations in blood >50pgg(-1) lipid. The half-life of 2,3,4,7,8-PeCDF for each patient was estimated using linear regression. Moreover, relationships between clinical and laboratory parameters and individual half-life were investigated by linear regression.
  
  
  RESULTS
  A shortened individual half-life for 2,3,4,7,8-PeCDF was significantly correlated with an increased red blood cell count, increased viscous secretions from the meibomian glands, existing black comedones, and severe cedar pollen allergy.
  
  
  CONCLUSIONS
  Symptoms that accelerate excretion of lipids from the body, such as viscous secretions from the meibomian glands, may lead to a shorter half-life of 2,3,4,7,8-PeCDF. Red blood cells are related to the half-life of 2,3,4,7,8-PeCDF. However, further studies are required to investigate the excretory mechanism of 2,3,4,7,8-PeCDF.
authors: Division of Social Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. shinyamatsumoto-tky@umin.ac.jp
authors: Shinya
authors: S
authors: Matsumoto
authors: Manabu
authors: M
authors: Akahane
authors: Yoshiyuki
authors: Y
authors: Kanagawa
authors: Jumboku
authors: J
authors: Kajiwara
authors: Takashi
authors: T
authors: Todaka
authors: Fumiko
authors: F
authors: Yasukawa
authors: Hiroshi
authors: H
authors: Uchi
authors: Masutaka
authors: M
authors: Furue
authors: Tomoaki
authors: T
authors: Imamura
mesh_terms: D000152:Acne Vulgaris / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001572:Benzofurans / Q000097:blood* / Q000493:pharmacokinetics; D004906:Erythrocyte Count; D005221:Fatigue / Q000209:etiology; D005260:Female; D006207:Half-Life; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011164:Porphyrias / Q000097:blood / Q000209:etiology*; D006255:Rhinitis, Allergic, Seasonal / Q000209:etiology
chemical_list: D001572:Benzofurans; C038890:2,3,4,7,8-pentachlorodibenzofuran