title: Exercise attenuates PCB-induced changes in the mouse gut microbiome.
abstract: BACKGROUND
  The gut microbiome, a dynamic bacterial community that interacts with the host, is integral to human health because it regulates energy metabolism and immune functions. The gut microbiome may also play a role in risks from environmental toxicants.
  
  
  OBJECTIVE
  We investigated the effects of polychlorinated biphenyls (PCBs) and exercise on the composition and structure of the gut microbiome in mice.
  
  
  METHODS
  After mice exercised voluntarily for 5 weeks, they were treated by oral gavage with a mixture of environmentally relevant PCB congeners (PCB153, PCB138, and PCB180; total PCB dose, 150 µmol/kg) for 2 days. We then assessed the microbiome by determination of 16S rRNA using microarray analysis.
  
  
  RESULTS
  Oral exposure to PCBs significantly altered the abundance of the gut microbiome in mice primarily by decreasing the levels of Proteobacteria. The activity level of the mice correlated with a substantial shift in abundance, biodiversity, and composition of the microbiome. Importantly, exercise attenuated PCB-induced changes in the gut microbiome.
  
  
  CONCLUSIONS
  Our results show that oral exposure to PCBs can induce substantial changes in the gut microbiome, which may then influence their systemic toxicity. These changes can be attenuated by behavioral factors, such as voluntary exercise.
authors: Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33136, USA.
authors: Jeong June
authors: JJ
authors: Choi
authors: Sung Yong
authors: SY
authors: Eum
authors: Evadnie
authors: E
authors: Rampersaud
authors: Sylvia
authors: S
authors: Daunert
authors: Maria T
authors: MT
authors: Abreu
authors: Michal
authors: M
authors: Toborek
mesh_terms: D000818:Animals; D019826:Cholic Acid / Q000494:pharmacology; D004785:Environmental Pollutants / Q000633:toxicity*; D005232:Fatty Acids, Volatile / Q000494:pharmacology; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008297:Male; D054892:Metagenome / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D010805:Physical Conditioning, Animal; D011078:Polychlorinated Biphenyls / Q000633:toxicity*
chemical_list: D004785:Environmental Pollutants; D005232:Fatty Acids, Volatile; D011078:Polychlorinated Biphenyls; D019826:Cholic Acid
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