title: 2-Amino-6-methyl-5-{5-[(naphthalen-2-yl-oxy)meth-yl]-1,3,4-oxadiazol-2-ylsulfan-yl}-4-(3-nitro-phen-yl)pyridine-3-carbonitrile.
abstract: The asymmetric unit of the title compound, C26H18N6O4S, contains two independent mol-ecules (A and B). The dihedral angles between the oxadiazole ring and naphthalene ring system are 42.59 (14) and 6.88 (14) Å in mol-ecules A and B, respectively. The dihedral angles between the pyridine and benzene rings in A and B are 65.53 (13 )and 87.67 (13) Å, respectively. In the crystal, mol-ecules A and B are linked through a pair of N-H⋯N hydrogen bonds involving one -NH2 group H atom and second pair of N-H⋯N hydrogen bonds involving the other -NH2 group H atom, forming an -ABAB- ribbon along [100] containing R 2 (2)(8) and R 2 (2)(12) ring motifs. These ribbons are further connected by weak C-H⋯N, C-H⋯O and C-H⋯π inter-actions, resulting in a three-dimensional network. The crystal studied was a non-merohedral twin with refined components 0.906 (1):0.094 (1).
authors: X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia ; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia.
authors: Hoong-Kun
authors: HK
authors: Fun
authors: C S
authors: CS
authors: Chidan Kumar
authors: Prescilla
authors: P
authors: Patrao
authors: A M A
authors: AM
authors: Khader
authors: Balakrishna
authors: B
authors: Kalluraya
references: Am J Physiol. 1994 Aug;267(2 Pt 2):H488-93
references: 8067400
references: Bioorg Med Chem. 2008 Feb 15;16(4):1822-31
references: 18248993
references: Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55
references: 19171970
references: Bioorg Med Chem. 1995 Sep;3(9):1241-5
references: 8564416
references: Bioorg Med Chem Lett. 2006 Oct 1;16(19):5036-40
references: 16876405
references: Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22
references: 18156677
references: Br J Haematol. 1995 Oct;91(2):434-44
references: 8547091
references: Jpn J Pharmacol. 1995 Mar;67(3):253-8
references: 7630043