title: Deciphering the New Role of the Greatwall/PP2A Pathway in Cell Cycle Control.
abstract: Mitotic division is induced by protein phosphorylation. For a long time the supported hypothesis was that mitotic entry and exit were the exclusive result of cyclin B-Cdk1 kinase activation and inactivation, whereas the phosphatase activity required to dephosphorylate mitotic substrates was thought to be constant during mitosis. Recent data demonstrate that phosphatase activity must also be tightly regulated to promote correct cell division. Here we describe the new pathway involved in phosphatase regulation and the questions that this discovery raises concerning the classic view of cell cycle regulation.
authors: Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoléculaire, CNRS UMR, Montpellier, France.
authors: Thierry
authors: T
authors: Lorca
authors: Anna
authors: A
authors: Castro
keywords: Greatwall; PP2A; mitosis
references: Science. 2010 Dec 17;330(6011):1670-3
references: 21164013
references: Nature. 1990 Apr 5;344(6266):503-8
references: 2138713
references: Cell Cycle. 2004 Jun;3(6):733-7
references: 15136768
references: J Neurochem. 2004 Jun;89(6):1318-24
references: 15189334
references: Cell. 2002 May 3;109(3):275-82
references: 12015977
references: Cancer Cell. 2005 Nov;8(5):355-68
references: 16286244
references: Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12427-31
references: 12221279
references: EMBO J. 2009 Sep 16;28(18):2786-93
references: 19680222
references: EMBO J. 1993 Jan;12(1):53-63
references: 8428594
references: Nat Cell Biol. 2009 May;11(5):644-51
references: 19396163
references: Cell. 2011 Nov 11;147(4):803-14
references: 22078879
references: Cell Cycle. 2010 Sep 1;9(17):3591-601
references: 20818157
references: Biochemistry. 2008 Nov 25;47(47):12357-64
references: 18973346
references: Nat Cell Biol. 2010 Sep;12(9):886-93
references: 20711181
references: Nat Rev Mol Cell Biol. 2007 Nov;8(11):894-903
references: 17912263
references: Nature. 1991 Jan 10;349(6305):132-8
references: 1846030
references: Mol Cell Biol. 2011 Jun;31(11):2262-75
references: 21444715
references: Mol Cell. 2006 Apr 7;22(1):83-91
references: 16600872
references: EMBO J. 2009 Sep 16;28(18):2777-85
references: 19696736
references: Biol Cell. 2001 Sep;93(1-2):15-25
references: 11730318
references: Cell. 1988 Jul 1;54(1):17-26
references: 3289755
references: Curr Opin Cell Biol. 2009 Dec;21(6):806-15
references: 19767188
references: Mol Biol Cell. 1992 Aug;3(8):927-39
references: 1392080
references: Dev Cell. 2011 Sep 13;21(3):506-19
references: 21871841
references: Nature. 1989 Nov 2;342(6245):39-45
references: 2682257
references: J Biol Chem. 2007 Nov 23;282(47):34555-67
references: 17893145
references: J Cell Sci. 2005 Aug 1;118(Pt 15):3523-30
references: 16030137
references: Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6629-33
references: 1631165
references: Mol Cell Biol. 2012 Apr;32(8):1337-53
references: 22354989
references: Neurosci Lett. 2001 Sep 14;310(2-3):77-80
references: 11585571
references: PLoS Genet. 2011 Aug;7(8):e1002225
references: 21852956
references: Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12564-9
references: 20538976
references: Mol Biol Cell. 2009 Nov;20(22):4777-89
references: 19793917
references: Nature. 2004 Dec 23;432(7020):980-7
references: 15616552
references: EMBO J. 1991 Feb;10(2):305-16
references: 1846803
references: Cell. 1987 May 22;49(4):559-67
references: 3032459
references: Cell. 2007 Jul 13;130(1):51-62
references: 17632056
references: Cancer Cell. 2010 Dec 14;18(6):641-54
references: 21156286
references: PLoS Genet. 2011 Aug;7(8):e1002227
references: 21852958
references: J Cell Sci. 2010 Jul 1;123(Pt 13):2281-91
references: 20554897
references: Development. 2008 Nov;135(22):3697-706
references: 18927152
references: Science. 2010 Dec 17;330(6011):1673-7
references: 21164014
references: J Biol Chem. 2010 Jun 4;285(23):17648-61
references: 20356833
references: J Cell Biol. 2004 Feb 16;164(4):487-92
references: 14970188
references: EMBO J. 1990 Mar;9(3):675-83
references: 2155777
references: Mol Biol Cell. 1993 Apr;4(4):397-411
references: 8389619