title: Butyrylcholinesterase (BChE) activity is associated with the risk of preeclampsia: influence on lipid and lipoprotein metabolism and oxidative stress.
abstract: OBJECTIVE
  To determine the butyrylcholinesterase (BChE) activity and phenotypes in preeclampsia and its possible association with lipid and lipoprotein metabolism and oxidative stress in preeclamptic women.
  
  
  METHODS
  In a case-control study, 101 pregnant women with normal pregnancy and 198 women with preeclampsia from Western Iran were studied. The serum BChE activity and phenotypes were measured using spectrophotometric method. The apolipoprotein E (APOE) genotypes were identified using PCR-RFLP. The serum malondialdehyde (MDA) level and total antioxidant capacity (TAC) were determined by HPLC and commercial kits, respectively.
  
  
  RESULTS
  The BChE activity and the frequency of non-usual BChE phenotype in preeclamptic women were significantly lower and higher, respectively compared to controls. There was a higher BChE activity in the presence of APOE ε3ε4 compared to ε3ε3 genotype in preeclamptic women. In addition, there were significant positive correlations between BChE activity and the levels of low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, total cholesterol (TC) and TAC. However, there was a negative but significant correlation between BChE activity and MDA level.
  
  
  CONCLUSIONS
  Our study for the first time indicated that BChE activity might be involved in the pathogenesis of preeclampsia through influence on lipid and lipoprotein metabolism and oxidative stress.
authors: Medical Biology Research Center .
authors: Zohreh
authors: Z
authors: Rahimi
authors: Reza
authors: R
authors: Ahmadi
authors: Asad
authors: A
authors: Vaisi-Raygani
authors: Ziba
authors: Z
authors: Rahimi
authors: Fariborz
authors: F
authors: Bahrehmand
authors: Abbas
authors: A
authors: Parsian
mesh_terms: D000328:Adult; D053318:Apolipoprotein E3 / Q000235:genetics; D002091:Butyrylcholinesterase / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D007492:Iran; D050356:Lipid Metabolism / Q000502:physiology*; D008074:Lipoproteins / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D012307:Risk Factors; D055815:Young Adult
chemical_list: D053318:Apolipoprotein E3; D008074:Lipoproteins; D002091:Butyrylcholinesterase