title: Thermal pain and sensory processing in children with sickle cell disease.
abstract: OBJECTIVE
  Early tissue injury and recurrent pain in sickle cell disease (SCD) may alter pain and sensory processing. In this study, we evaluate thermal pain and sensory processing for 27 children aged 10.3 to 18.3 years with SCD and 28 African-American control patients.
  
  
  METHODS
  Outcome measures included heat and cold detection thresholds, heat and cold pain thresholds, and thermal perceptual sensitization at the volar surface of the dominant forearm and thenar eminence of the nondominant hand.
  
  
  RESULTS
  Children with SCD were less sensitive to heat detection (P=0.006) and cold detection (P=0.015) stimuli at the thenar eminence compared with controls. At the forearm, no difference was found between groups for cold (P=0.58) or heat (P=0.07) detection thresholds. Children with SCD had increased sensitivity to cold pain at the forearm (P=0.03) compared with controls, but not when measured at the thenar eminence (P=0.084). There was no evidence that children with SCD had altered heat pain thresholds compared with controls. There was no difference between groups for perceptual sensitization at the thenar eminence (41% vs. 39%) (χ=0.15, P>0.1) or at the forearm (30% vs. 36%) (χ=0.23, P>0.5).
  
  
  CONCLUSIONS
  Three of ten quantitative sensory tests were found to differ between groups. These results suggest that SCD may influence pain and sensory processing in children, but our interpretation is necessarily cautious. Due to the small differences in measures found between groups, further investigation is required to confirm our findings. If confirmed, the development of population-specific reference standards for quantitative sensory testing may emerge as a useful clinical tool for pain physicians in identifying and quantifying pain and sensory processing in children with SCD.
authors: Departments of ‡Pediatrics, Division of Hematology/Oncology *Anesthesia and Pain Medicine, the Hospital for Sick Children §Department of Anaesthesia, Faculty of Medicine, University of Toronto, ON, Canada †Department of Anaesthesia, Faculty of Medicine, University College Cork, Cork, Ireland.
authors: James D
authors: JD
authors: O'Leary
authors: Mark W
authors: MW
authors: Crawford
authors: Isaac
authors: I
authors: Odame
authors: George D
authors: GD
authors: Shorten
authors: Patricia A
authors: PA
authors: McGrath
mesh_terms: D000293:Adolescent; D001741:Black or African American; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000755:Anemia, Sickle Cell / Q000150:complications / Q000503:physiopathology*; D002648:Child; D003080:Cold Temperature; D005260:Female; D005542:Forearm / Q000503:physiopathology*; D006225:Hand / Q000503:physiopathology*; D006358:Hot Temperature; D006801:Humans; D008297:Male; D010146:Pain / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology*; D010812:Physical Stimulation; D012684:Sensory Thresholds / Q000502:physiology*; D013696:Temperature
chemical_list: D000701:Analgesics, Opioid