title: Paucisymptomatic Marchiafava-Bignami disease with relevant diffusion-weighted MRI lesions.
abstract: Marchiafava-Bignami disease (MBD) is a rare alcohol-associated disorder characterized by demyelization and necrosis of the corpus callosum. Diffusion-weighted (DW) MRI may reveal the lesions in patients showing serious clinical manifestations, high mortality rate and severe cognitive sequelae, though some cases with good outcome have been reported. We describe a case of a man with a history of chronic alcohol abuse associated with malabsorption; the man presented mild clinical signs on the first neurological exam, despite the presence of DW-MRI lesions, bilaterally involving entire corpus callosum, that are compatible with MBD diagnosis.
authors: 1Department of Neuroscience, University of Rome Tor Vergata , Rome , Italy.
authors: Maria Giovanna
authors: MG
authors: Sarpa
authors: Davide
authors: D
authors: Ferrazzoli
authors: Roberto
authors: R
authors: Massa
authors: Francesco
authors: F
authors: Garaci
authors: Francesca
authors: F
authors: Izzi
authors: Andrea
authors: A
authors: Romigi
authors: Claudio
authors: C
authors: Liguori
authors: Fabio
authors: F
authors: Placidi
mesh_terms: D000368:Aged; D000437:Alcoholism / Q000150:complications; D003337:Corpus Callosum / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D020233:Gait Disorders, Neurologic / Q000209:etiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008286:Malabsorption Syndromes / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D008297:Male; D054319:Marchiafava-Bignami Disease / Q000188:drug therapy / Q000473:pathology* / Q000523:psychology; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D011379:Prognosis; D016896:Treatment Outcome; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D014815:Vitamins