title: The interaction of antiemetic dose of droperidol with propofol on QT interval during anesthetic induction.
abstract: OBJECTIVE
  We investigated the effect of low-dose droperidol on heart rate-corrected QT (QTc) interval and interaction with propofol.
  
  
  METHODS
  Seventy-two patients undergoing upper limb surgery were included in this study. Patients were randomly allocated to one of three groups: group S (n = 24), which received 1 ml saline; group D1 (n = 24), which received 1.25 mg droperidol; or group D2 (n = 24), which received 2.5 mg droperidol. One minute later, fentanyl (3 μg/kg) was administered. Two minutes after fentanyl administration, anesthesia was induced using propofol (1.5 mg/kg) and vecronium. Tracheal intubation was performed 3 min after the administration of propofol. Heart rate, mean arterial pressure, bispectral index, and QTc interval were recorded at the following time points: immediately before the droperidol injection (baseline); 3 min after the saline or droperidol injection; 3 min after the propofol injection; and 2 min after tracheal intubation.
  
  
  RESULTS
  Compared to baseline, the QTc interval in group S and group D1 was significantly shorter after propofol injection, but recovered after tracheal intubation. In group D2, the QTc interval was significantly prolonged after droperidol injection, but recovered after propofol injection, and was significantly prolonged after tracheal intubation.
  
  
  CONCLUSIONS
  We found that saline or 1.25 mg droperidol did not prolong QTc interval, whereas 2.5 mg droperidol prolonged the QTc interval significantly, and that propofol injection counteracted the prolongation of the QTc interval induced by 2.5 mg droperidol.
authors: Department of Anesthesia, Nagasaki Rosai Hospital, 2-12-5 Setogoe, Sasebo, 857-0134, Japan.
authors: Tomomi
authors: T
authors: Toyoda
authors: Yoshiaki
authors: Y
authors: Terao
authors: Makito
authors: M
authors: Oji
authors: Mai
authors: M
authors: Okada
authors: Makoto
authors: M
authors: Fukusaki
authors: Koji
authors: K
authors: Sumikawa
mesh_terms: D000328:Adult; D000368:Aged; D000758:Anesthesia / Q000379:methods; D000932:Antiemetics / Q000008:administration & dosage*; D062186:Arterial Pressure / Q000187:drug effects; D004329:Droperidol / Q000008:administration & dosage*; D004347:Drug Interactions; D004562:Electrocardiography / Q000187:drug effects / Q000379:methods; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage*; D011446:Prospective Studies
chemical_list: D000932:Antiemetics; D004329:Droperidol; D005283:Fentanyl; D015742:Propofol
references: Anesthesiology. 2006 Feb;104(2):255-60
references: 16436843
references: Anesth Analg. 2006 Nov;103(5):1155-62
references: 17056948
references: Anesthesiology. 2005 Jun;102(6):1101-5
references: 15915020
references: Anesthesiology. 2005 Jun;102(6):1094-100
references: 15915019
references: Anaesthesia. 2010 Jul;65(7):679-83
references: 20528837
references: J Clin Monit Comput. 2013 Jun;27(3):243-8
references: 23242843
references: Am J Cardiol. 1988 Jan 1;61(1):83-7
references: 3337022
references: Anesth Analg. 2002 Oct;95(4):789-90
references: 12351246
references: Anesth Analg. 2008 Apr;106(4):1161-70, table of contents
references: 18349188
references: Anaesthesia. 2008 Oct;63(10):1056-60
references: 18616522
references: Anesth Analg. 2008 May;106(5):1402-6, table of contents
references: 18420851
references: Anesth Analg. 2003 Jul;97(1):62-71, table of contents
references: 12818945
references: Neurocrit Care. 2010 Dec;13(3):347-54
references: 20652444
references: Anesth Analg. 1994 Nov;79(5):983-6
references: 7978420
references: Anesthesiology. 2007 Oct;107(4):531-6
references: 17893447
references: Anaesthesia. 2001 Mar;56(3):248-50
references: 11251432
references: Anesthesiology. 2008 Aug;109(2):206-12
references: 18648229
references: J Pharmacol Sci. 2009 Jul;110(3):334-43
references: 19571462
references: J Clin Pharmacol. 2006 May;46(5):498-507
references: 16638733