title: Recent advances in the study of enzyme promiscuity in the tautomerase superfamily.
abstract: Catalytic promiscuity and evolution: Many enzymes exhibit catalytic promiscuity--the ability to catalyze reactions other than their biologically relevant one. These reactions can serve as starting points for both natural and laboratory evolution of new enzymatic functions. Recent advances in the study of enzyme promiscuity in the tautomerase superfamily are discussed.
authors: Department of Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors: Bert-Jan
authors: BJ
authors: Baas
authors: Ellen
authors: E
authors: Zandvoort
authors: Edzard M
authors: EM
authors: Geertsema
authors: Gerrit J
authors: GJ
authors: Poelarends
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D007535:Isomerases / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D013379:Substrate Specificity
chemical_list: D007535:Isomerases