title: Early stage epithelial ovarian cancers: a study of morphologic prognostic factors.
abstract: We intended to reevaluate the morphologic prognostic factors for early-stage ovarian carcinomas. We reviewed 111 patients diagnosed with early-stage ovarian cancer who had undergone primary surgery at Hacettepe Hospital between 1984 and 2001, using diagnostic criteria from the WHO-2003 classification. We applied the Universal grading system suggested by Shimizu/Silverberg and noted FIGO-stage, histotype, tumor size, bilaterality, and endometriosis. These features were compared with each other and survival. The survival analysis was carried out by Kaplan-Meier curves. Of the cases, 52 were reclassified as 'borderline tumor' or 'cystadenoma with borderline foci' and 59 as 'invasive carcinoma'. FIGO-stage and mitotic count were significant for survivals of 59 patients with cancer. Mitotic index was also significant for the probability of metastasis. The patients with stage-II cancer had 5.65 times more risk of recurrence than stage-I cancer. The 5-year overall and disease-free survivals rates were 90.6% and 87.5% for stage-I, 54.7% and 39.3% for stage-II, respectively. Universal grade did not reach statistical significance for survivals but it was related to FIGO-stage significantly. In conclusion, FIGO-stage is the most reliable prognosticator. Although prognostic value of universal grade is not significant, mitotic count may provide important prognostic information for early-stage ovarian carcinomas.
authors: Department of Pathology, Baskent University Medical School, Bahcelievler, Ankara, Turkey. aysenterzi@yahoo.co.uk
authors: Aysen
authors: A
authors: Terzi
authors: Isıl Yıldız
authors: IY
authors: Aktaş
authors: Anıl
authors: A
authors: Dolgun
authors: Ali
authors: A
authors: Ayhan
authors: Türkan
authors: T
authors: Küçükali
authors: Alp
authors: A
authors: Usubütün
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D000077216:Carcinoma, Ovarian Epithelial; D016009:Chi-Square Distribution; D003537:Cystadenoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D004715:Endometriosis / Q000473:pathology; D005260:Female; D006785:Hospitals, University; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D008940:Mitotic Index; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden; D014421:Turkey