title: Mauritic acid: a new dammarane triterpene from the roots of Mauritia flexuosa L.f. (Arecaceae).
abstract: A new dammarane triterpene named mauritic acid (1) was isolated from the roots of Mauritia flexuosa L.f. The complete structural assignment of this new compound was elucidated from spectroscopic methods. Moreover, this compound was evaluated for its cytotoxicity against human cancer cell lines (OVCAR-8, PCM3, NCIH358M and different leukaemia cell strains). The mauritic acid presented significant cytotoxicity against OVCAR-8, PCM3 and NCIH358M cell lines with IC50 3.02, 2.39 and 6.19 μM, respectively. The triterpenes 1 and 2 were also tested for their antimicrobial activity against 15 strains of microorganisms, including fungi and bacteria, with the best minimal inhibitory concentration values ranging from 50.8 to 203.5 μM.
authors: a Department of Chemistry , University of Amazonas , Manaus , 69077000 , Brazil.
authors: Hector H F
authors: HH
authors: Koolen
authors: Elzalina R
authors: ER
authors: Soares
authors: Felipe M A
authors: FM
authors: da Silva
authors: Aimêe A
authors: AA
authors: de Oliveira
authors: Antonia Q L
authors: AQ
authors: de Souza
authors: Lívia S
authors: LS
authors: de Medeiros
authors: Edson
authors: E
authors: Rodrigues-Filho
authors: Bruno C
authors: BC
authors: Cavalcanti
authors: Cláudia O
authors: CO
authors: Pessoa
authors: Manoel O
authors: MO
authors: Moraes
authors: Marcos J
authors: MJ
authors: Salvador
authors: Afonso D L
authors: AD
authors: de Souza
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D028023:Arecaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C000590662:mauritic acid