title: Long-term survival in elderly patients with stable coronary disease.
abstract: BACKGROUND
  This study aimed to assess long-term prognosis of stable coronary artery disease (sCAD) in patients aged ≥ 75 years and to identify clinical predictors of cardiovascular and overall mortality.
  
  
  METHODS
  From February 2000 to January 2007, 391 outpatients aged ≥ 75 years (median 78 years, interquartile range [IQR] 76-81 years, 66% male) with sCAD were recruited in this prospective cohort study. Associations of baseline variables with long-term cardiovascular and all-cause death were investigated.
  
  
  RESULTS
  After up to 11 years of follow-up (median 4 years, IQR 2-6 years), 89 patients died (23%, 5·45%/year), 35 from cardiovascular causes (9%, 2·14%/year). Multivariate analysis identified family history of coronary disease (HR 4·28, 95% CI 1·22-15·02, P = 0·02), baseline atrial fibrillation (HR 3·18, 95% CI 1·37-7·39, P = 0·007), age (HR 1·61 per 5 year increase, 95% CI 1·04-2·50, P = 0·03), resting heart rate (HR 1·26 per 5 bpm increase, 95% CI 1·09-1·47, P = 0·003) and previous revascularization (HR 0·17, 95% CI 0·04-0·77, P = 0·02) as independent predictors of cardiovascular death, and previous acute coronary syndrome (HR 4·93, 95% CI 1·49-16·30, P = 0·009), baseline atrial fibrillation (HR 1·96, 95% CI 1·12-3·43, P = 0·02), tobacco use (HR 1·69, 95% CI 1·00-2·84, P = 0·049 for ex-smoking and HR 6·78, 95% CI 0·89-51·47, P = 0·06 for active smoking), age (HR 1·58 per 5 year increase, 95% CI 1·18-2·11, P = 0·002), resting heart rate (HR 1·10 per 5 bpm increase, 95% CI 1·00-1·22, P = 0·05) and diastolic blood pressure (HR 0·97, 95% CI 0·94-0·99, P = 0·01) as independent predictors of overall mortality.
  
  
  CONCLUSIONS
  In this study, 4-years overall mortality was 23% among elderly patients with sCAD. Simple clinical variables can identify patients at higher risk of mortality.
authors: Cardiology Department, Reina Sofía University Hospital, Córdoba, Spain. maruor@gmail.com
authors: Martín
authors: M
authors: Ruiz Ortiz
authors: Cristina
authors: C
authors: Ogayar
authors: Elías
authors: E
authors: Romo
authors: Dolores
authors: D
authors: Mesa
authors: Mónica
authors: M
authors: Delgado
authors: Manuel
authors: M
authors: Anguita
authors: Juan C
authors: JC
authors: Castillo
authors: José M
authors: JM
authors: Arizón
authors: José
authors: J
authors: Suárez de Lezo
mesh_terms: D054058:Acute Coronary Syndrome / Q000401:mortality; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000401:mortality; D003324:Coronary Artery Disease / Q000401:mortality*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D009204:Myocardial Revascularization / Q000401:mortality; D011379:Prognosis; D013030:Spain / Q000453:epidemiology
keywords: Elderly; mortality; prognosis; stable coronary artery disease