title: CEACAM1 expression in oligodendrocytes of the developing rat brain shows a spatiotemporal relation to myelination and is altered in a model of encephalopathy of prematurity.
abstract: CEACAM1 is the founder molecule of the family of 'carcinoembryonic antigen-related cell adhesion molecules' and part of the immunoglobulin superfamily. Due to its role as a coreceptor to many other receptors (e.g. Toll-like receptor 2, Toll-like receptor 4, T-cell receptor, B-cell receptor, epidermal growth factor receptor and vascular endothelial growth factor receptor) and its different isoforms, CEACAM1 is a multifunctional protein with an impact on proliferation and differentiation of multiple cell types. Although different modes of action in other tissues are described, the role of CEACAM1 in the developing brain remains elusive. Here we report for the first time that CEACAM1 is expressed ontogenetically in oligodendrocytes of the developing rat brain, and that CEACAM1 expression has a spatiotemporal relation to myelination. In addition, CEACAM1 expression is altered in a model of hyperoxia- and inflammation-induced encephalopathy of prematurity, a myelination disorder of children born preterm. Furthermore, primary oligodendrocytes stimulated with CEACAM1 show increased myelination. Therefore, we postulate that CEACAM1 is, at least in part, involved in hyperoxia- and inflammation-induced disruption of myelination, but may also play a role in intact myelination as it is ontogenetically expressed in myelinating oligodendrocytes.
authors: Department of Pediatrics 1, Neonatology, University Hospital Essen, Essen, Germany. sebastian.prager@uk-essen.de
authors: Sebastian
authors: S
authors: Prager
authors: Bernhard B
authors: BB
authors: Singer
authors: Ivo
authors: I
authors: Bendix
authors: Gerald W
authors: GW
authors: Schlager
authors: Frederik
authors: F
authors: Bertling
authors: Burcin
authors: B
authors: Ceylan
authors: Matthias
authors: M
authors: Keller
authors: Ursula
authors: U
authors: Felderhoff-Mueser
authors: Süleyman
authors: S
authors: Ergün
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis*; D001921:Brain / Q000254:growth & development* / Q000378:metabolism*; D001927:Brain Diseases / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D004195:Disease Models, Animal; D005455:Fluorescent Antibody Technique; D015151:Immunoblotting; D009836:Oligodendroglia / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D015703:Antigens, CD; C069847:CD66 antigens; D015815:Cell Adhesion Molecules