title: NS3 of bluetongue virus interferes with the induction of type I interferon.
abstract: Upon infection with Bluetongue virus (BTV), an arthropod-borne virus, type I interferon (IFN-I) is produced in vivo and in vitro. IFN-I is essential for the establishment of an antiviral cellular response, and most if not all viruses have elaborated strategies to counteract its action. In this study, we assessed the ability of BTV to interfere with IFN-I synthesis and identified the nonstructural viral protein NS3 as an antagonist of the IFN-I system.
authors: Maisons-Alfort Laboratory for Animal Health, ANSES, INRA, ENVA, UMR 1161 Virology, Maisons-Alfort, France.
authors: Emilie
authors: E
authors: Chauveau
authors: Virginie
authors: V
authors: Doceul
authors: Estelle
authors: E
authors: Lara
authors: Emmanuel
authors: E
authors: Breard
authors: Corinne
authors: C
authors: Sailleau
authors: Pierre-Olivier
authors: PO
authors: Vidalain
authors: Eliane F
authors: EF
authors: Meurs
authors: Stéphanie
authors: S
authors: Dabo
authors: Isabelle
authors: I
authors: Schwartz-Cornil
authors: Stéphan
authors: S
authors: Zientara
authors: Damien
authors: D
authors: Vitour
mesh_terms: D015153:Blotting, Western; D001820:Bluetongue virus / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D057809:HEK293 Cells; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology*; D007370:Interferon Type I / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008156:Luciferases; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology*; D017361:Viral Nonstructural Proteins / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D007370:Interferon Type I; C075080:S10 protein, Bluetongue virus; D017361:Viral Nonstructural Proteins; D008156:Luciferases
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