title: Survival advantage of radiofrequency ablation for hepatocellular carcinoma: comparison with ethanol injection.
abstract: OBJECTIVE
  The aims of this study were to compare long-term prognosis of patients with hepatocellular carcinoma (HCC) treated with radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI).
  
  
  METHODS
  Two hundred and thirteen patients with HCC were initially treated with PEI or RFA at Saga University Hospital between 1990 and 2004. The present study included 190 patients: 98 treated with PEI from 1990 to 1999, and 92 with RFA from 2000 to 2004. The association of treatment method with survival prognosis was evaluated by multivariate analysis.
  
  
  RESULTS
  There were no significant differences in gender, etiology, and tumor stage between the two groups. Five-year survival rate in the PEI group was 40% and 51% in the RFA group. According to tumor stage, there were no differences in 5-year survival rate between the two groups for tumor stage I and III. For stage II patients, RFA had better survival than PEI (48% vs. 28%, p = 0.03). Multivariate analysis indicated that RFA was more effective for long-term survival than PEI in patients with tumor stage II (p = 0.04).
  
  
  CONCLUSIONS
  Compared to PEI, RFA improved survival in patients with stage II HCC, indicating a therapeutic advantage of RFA.
authors: Satoshi
authors: S
authors: Oeda
authors: Toshihiko
authors: T
authors: Mizuta
authors: Hiroshi
authors: H
authors: Isoda
authors: Takuya
authors: T
authors: Kuwashiro
authors: Shinji
authors: S
authors: Iwane
authors: Hirokazu
authors: H
authors: Takahashi
authors: Yasunori
authors: Y
authors: Kawaguchi
authors: Yuichiro
authors: Y
authors: Eguchi
authors: Iwata
authors: I
authors: Ozaki
authors: Keitaro
authors: K
authors: Tanaka
authors: Kazuma
authors: K
authors: Fujimoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D017115:Catheter Ablation; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015996:Survival Rate
chemical_list: D000431:Ethanol