title: Systems biology in aging: linking the old and the young.
abstract: Aging can be defined as a process of progressive decline in the physiological capacity of an organism, manifested by accumulated alteration and destabilization at the whole system level. Systems biology approaches offer a promising new perspective to examine the old problem of aging. We begin this review by introducing the concepts of systems biology, and then illustrate the application of systems biology approaches to aging research, from gene expression profiling to network analysis. We then introduce the network that can be constructed using known lifespan and aging regulators, and conclude with a look forward to the future of systems biology in aging research. In summary, systems biology is not only a young field that may help us understand aging at a higher level, but also an important platform that can link different levels of knowledge on aging, moving us closer to a more comprehensive control of systematic decline during aging.
authors: Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China ; Center of Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
authors: Lei
authors: L
authors: Hou
authors: Jialiang
authors: J
authors: Huang
authors: Christopher D
authors: CD
authors: Green
authors: Jerome
authors: J
authors: Boyd-Kirkup
authors: Wei
authors: W
authors: Zhang
authors: Xiaoming
authors: X
authors: Yu
authors: Wenxuan
authors: W
authors: Gong
authors: Bing
authors: B
authors: Zhou
authors: Jing-Dong J
authors: JD
authors: Han
keywords: Aging; Genomics; Longevity; Network analysis.; Proteomics; Systems biology
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