title: Egg consumption and risk of cardiovascular diseases and diabetes: a meta-analysis.
abstract: OBJECTIVE
  To assess the dose-response relationship between egg consumption and the risk of cardiovascular diseases (CVD) and diabetes.
  
  
  METHODS
  We systematically searched MEDLINE database through December 2012. Fixed- or random-effects model was used to pool the relative risks (RRs) and their 95% confidence intervals (CIs). Subgroup analyses was performed to explore the potential sources of heterogeneity. Weighted linear regression model was used to estimate the dose-response relationship.
  
  
  RESULTS
  Fourteen studies involving 320,778 subjects were included. The pooled RRs of the risk of CVD, CVD for separated diabetes patients, and diabetes for the highest vs lowest egg intake were 1.19 (95% CI 1.02-1.38), 1.83 (95% CI 1.42-2.37), 1.68 (95% CI 1.41-2.00), respectively. For each 4/week increment in egg intake, the RRs of the risk for CVD, CVD for separated diabetes patients, diabetes was 1.06 (95% CI 1.03-1.10), 1.40 (95% CI 1.25-1.57), 1.29 (95% CI 1.21-1.37), respectively. Subgroup analyses showed that population in other western countries have increased CVD than ones in USA (RR 2.00, 95% CI 1.14 to 3.51 vs 1.13, 95% CI 0.98 to 1.30, P = 0.02 for subgroup difference).
  
  
  CONCLUSIONS
  Our study suggests that there is a dose-response positive association between egg consumption and the risk of CVD and diabetes.
authors: State Key Laboratory of Cardiovascular Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors: Yuehua
authors: Y
authors: Li
authors: Chenghui
authors: C
authors: Zhou
authors: Xianliang
authors: X
authors: Zhou
authors: Lihuan
authors: L
authors: Li
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology*; D004531:Eggs; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008297:Male; D018570:Risk Assessment; D012307:Risk Factors
keywords: Cardiovascular disease; Diabetes; Egg; Meta-analysis