title: Successful treatment of severe iron intoxication with gastrointestinal decontamination, deferoxamine, and hemodialysis.
abstract: Acute iron poisoning is a common and potentially serious problem in the pediatric population. Early recognition and treatment is crucial for a better outcome and to prevent morbidity and mortality. An 18-year-old female, who had accidental ingestion of 50 tablets of ferrous sulfate (100 mg of elemental iron per 335 mg tablet), 100 mg/kg of elemental iron, developed acute gastrointestinal and neurologic signs of toxicity and severe anion gap metabolic acidosis. The patient had received gastrointestinal decontamination, deferoxamine (DFO) infusion, and hemodialysis (HD) resulting in a decrease in serum iron concentration from 2150 to 160 mcg/dL at 24-h post-ingestion and improved mental status. Our cases demonstrate that HD may assist in decreasing serum iron concentration and improving clinical status in patients with massive overdose and life-threatening toxicity.
authors: Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Centre, Dr HL Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India. drmanojgumber@rediffmail.com
authors: Manoj R
authors: MR
authors: Gumber
authors: Vivek B
authors: VB
authors: Kute
authors: Pankaj R
authors: PR
authors: Shah
authors: Aruna V
authors: AV
authors: Vanikar
authors: Himanshu V
authors: HV
authors: Patel
authors: Manish R
authors: MR
authors: Balwani
authors: Pramod P
authors: PP
authors: Ghuge
authors: Hargovind L
authors: HL
authors: Trivedi
mesh_terms: D000293:Adolescent; D003676:Deferoxamine / Q000627:therapeutic use*; D005260:Female; D005751:Gastric Lavage; D000075322:Heavy Metal Poisoning; D006801:Humans; D007501:Iron / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy*; D006435:Renal Dialysis; D017262:Siderophores / Q000627:therapeutic use*
chemical_list: D017262:Siderophores; D007501:Iron; D003676:Deferoxamine