title: The role of the bacterial mismatch repair system in SOS-induced mutagenesis: a theoretical background.
abstract: A theoretical study is performed of the possible role of the methyl-directed mismatch repair system in the ultraviolet-induced mutagenesis of Escherichia coli bacterial cells. For this purpose, mathematical models of the SOS network, translesion synthesis and mismatch repair are developed. Within the proposed models, the key pathways of these repair systems were simulated on the basis of modern experimental data related to their mechanisms. Our model approach shows a possible mechanistic explanation of the hypothesis that the bacterial mismatch repair system is responsible for attenuation of mutation frequency during ultraviolet-induced SOS response via removal of the nucleotides misincorporated by DNA polymerase V (the UmuD'2C complex).
authors: Laboratory of Radiation Biology, Joint Institute for Nuclear Research, 6 Joliot-Curie Street, 141980 Dubna, Moscow Region, Russia. dem@jinr.ru
authors: Oleg V
authors: OV
authors: Belov
authors: Ochbadrakh
authors: O
authors: Chuluunbaatar
authors: Mikhail I
authors: MI
authors: Kapralov
authors: Nasser H
authors: NH
authors: Sweilam
mesh_terms: D053843:DNA Mismatch Repair / Q000528:radiation effects*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D016296:Mutagenesis / Q000528:radiation effects*; D009154:Mutation; D013014:SOS Response, Genetics / Q000528:radiation effects*; D014466:Ultraviolet Rays
keywords: Mathematical modeling; Mismatch repair; SOS response; UV mutagenesis