title: The family that eats together stays together: new p53 family transcriptional targets in autophagy.
abstract: Autophagy is a biological process that is crucial to maintain cellular homeostasis and is regulated by several metabolic pathways, including the p53 tumor suppressor pathway. In this issue of Genes & Development, Kenzelmann Broz and colleagues (pp. 1016-1031) show how the p53 family as a whole, including p63 and p73, collaborate in controlling autophagy to support tumor suppression.
authors: Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
authors: Marco
authors: M
authors: Napoli
authors: Elsa R
authors: ER
authors: Flores
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics*; D005347:Fibroblasts / Q000166:cytology* / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D016159:Tumor Suppressor Protein p53
keywords: ChIP-seq; RNA-seq; autophagy; p53; tumor suppression
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