title: Bacterial subversion of host innate immune pathways.
abstract: The pathogenesis of infection is a continuously evolving battle between the human host and the infecting microbe. The past decade has brought a burst of insights into the molecular mechanisms of innate immune responses to bacterial pathogens. In parallel, multiple specific mechanisms by which microorganisms subvert these host responses have been uncovered. This Review highlights recently characterized mechanisms by which bacterial pathogens avoid killing by innate host responses, including autophagy pathways and a proinflammatory cytokine transcriptional response, and by the manipulation of vesicular trafficking to avoid the toxicity of lysosomal enzymes.
authors: Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Cambridge, MA 02139, USA.
authors: Leigh A
authors: LA
authors: Baxt
authors: Anna Cristina
authors: AC
authors: Garza-Mayers
authors: Marcia B
authors: MB
authors: Goldberg
mesh_terms: D001343:Autophagy / Q000276:immunology*; D001419:Bacteria / Q000276:immunology* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D058947:Bacterial Secretion Systems; D029968:Escherichia coli Proteins / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D010587:Phagocytosis; D014158:Transcription, Genetic
chemical_list: D058947:Bacterial Secretion Systems; D029968:Escherichia coli Proteins; C429282:EspG protein, E coli