title: Relationship between the proteasomal system and autophagy.
abstract: TWO MAJOR PATHWAYS DEGRADE MOST CELLULAR PROTEINS IN EUKARYOTIC CELLS: the ubiquitin-proteasome system (UPS), which usually degrades the majority of proteins, and autophagy, primarily responsible for the degradation of most long-lived or aggregated proteins and cellular organelles. Disruption of these processes can contribute to pathology of a variety of diseases. Further, both pathways are critical for the maintenance of several aspects of cellular homeostasis, but, until recently, were thought to be largely distinct. Recent advances in this field, however, now strongly suggest that their activities are carefully orchestrated through several interfacing elements that are presented and discussed in this review.
authors: Laboratory of Stress and Pathologies of the Cytoskeleton, Unit of Functional and Adaptive Biology (BFA) affiliated with CNRS (EAC4413), University Paris Diderot-Paris 7 75250 Paris Cedex 13, France.
authors: Alain
authors: A
authors: Lilienbaum
keywords: Proteasome; autophagy; homeostasis; ubiquitin
references: Mol Cell. 2009 Feb 27;33(4):505-16
references: 19250911
references: Am J Physiol Gastrointest Liver Physiol. 2000 Nov;279(5):G961-74
references: 11052993
references: Science. 2004 Aug 27;305(5688):1292-5
references: 15333840
references: J Biol Chem. 2005 Dec 2;280(48):40282-92
references: 16192271
references: J Neurochem. 2009 Nov;111(4):1062-73
references: 19765191
references: J Cell Sci. 2011 Jan 15;124(Pt 2):161-70
references: 21187343
references: J Neurochem. 2002 Oct;83(1):176-85
references: 12358741
references: J Biol Chem. 2007 Dec 28;282(52):37298-302
references: 17986448
references: Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14344-9
references: 12374861
references: Mol Cell Biol. 2003 Aug;23(15):5198-207
references: 12861006
references: J Mol Biol. 2004 Aug 27;341(5):1367-79
references: 15321727
references: J Cell Sci. 2012 Feb 1;125(Pt 3):539-48
references: 22389393
references: Oncogene. 2010 Jan 21;29(3):451-62
references: 19881538
references: FASEB J. 1997 Jun;11(7):526-34
references: 9212076
references: Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20567-74
references: 19074260
references: Autophagy. 2010 Jan;6(1):126-37
references: 20061800
references: Cell. 2011 Sep 2;146(5):682-95
references: 21884931
references: Mol Biol Cell. 2008 Aug;19(8):3290-8
references: 18508918
references: Cell. 2010 Nov 24;143(5):677-81
references: 21111228
references: Biochim Biophys Acta. 2012 Jan;1824(1):68-88
references: 22024571
references: Mol Cell. 2008 Jun 20;30(6):678-88
references: 18570871
references: Mol Cell. 2010 Oct 22;40(2):280-93
references: 20965422
references: Curr Opin Cell Biol. 2010 Apr;22(2):192-8
references: 19962293
references: J Biol Chem. 1996 Feb 2;271(5):2823-31
references: 8576261
references: Mol Cell. 2009 Feb 27;33(4):517-27
references: 19250912
references: Biochim Biophys Acta. 2012 Jan;1824(1):3-13
references: 21435401
references: J Mol Cell Cardiol. 2012 Mar;52(3):526-37
references: 22085703
references: Biochemistry (Mosc). 2009 Dec;74(13):1411-42
references: 20210701
references: EMBO J. 2004 May 5;23(9):1977-86
references: 15071506
references: Mol Cell. 2010 Oct 22;40(2):310-22
references: 20965424
references: Circ Res. 2007 Mar 30;100(6):914-22
references: 17332429
references: Nat Rev Mol Cell Biol. 2012 Jan 18;13(2):89-102
references: 22251901
references: J Cell Sci. 2011 Feb 15;124(Pt 4):495-9
references: 21282471
references: Cell. 2008 Jan 11;132(1):27-42
references: 18191218
references: Cell. 2010 Nov 24;143(5):682-5
references: 21111229
references: Cell Death Differ. 2009 Jul;16(7):956-65
references: 19373247
references: Annu Rev Cell Dev Biol. 2011;27:107-32
references: 21801009
references: FEBS Lett. 2010 Apr 2;584(7):1359-66
references: 20146925
references: Cancer Res. 2009 May 15;69(10):4415-23
references: 19417138
references: Cell Death Differ. 2009 Jul;16(7):939-46
references: 19229244
references: FEBS Lett. 2010 Apr 2;584(7):1393-8
references: 20040365
references: J Mol Cell Cardiol. 2011 Oct;51(4):584-93
references: 21723289
references: Nat Rev Mol Cell Biol. 2010 Nov;11(11):777-88
references: 20944667
references: FEBS Lett. 2001 Nov 30;509(1):22-6
references: 11734199
references: Trends Biochem Sci. 1997 Jun;22(6):195-6
references: 9204704
references: J Mol Med (Berl). 2011 Dec;89(12):1175-82
references: 21818581
references: Mech Ageing Dev. 2000 Jan 24;113(1):61-70
references: 10708250
references: EMBO Rep. 2008 Sep;9(9):859-64
references: 18704115
references: J Biol Chem. 1992 May 25;267(15):10515-23
references: 1587832
references: EMBO J. 2002 Jul 1;21(13):3516-25
references: 12093752
references: Gen Comp Endocrinol. 2011 May 15;172(1):39-43
references: 21324320
references: J Cell Sci. 2004 Jun 1;117(Pt 13):2687-97
references: 15138286
references: Cancer Res. 2007 Oct 15;67(20):9677-84
references: 17942897
references: Autophagy. 2008 Feb;4(2):141-50
references: 17986870
references: Nat Cell Biol. 2006 Apr;8(4):398-406
references: 16547522
references: Nat Rev Mol Cell Biol. 2005 Aug;6(8):610-21
references: 16064137
references: Nature. 2007 Jun 14;447(7146):859-63
references: 17568747
references: Mol Cell. 2010 Apr 23;38(2):265-79
references: 20417604
references: J Biol Chem. 1998 Apr 10;273(15):8820-8
references: 9535861
references: Annu Rev Biochem. 2005;74:739-89
references: 15952902
references: J Biol Chem. 2000 Jul 7;275(27):20295-301
references: 10791958
references: Cell. 2003 Dec 12;115(6):727-38
references: 14675537
references: Biochem Biophys Res Commun. 2004 Jan 9;313(2):453-8
references: 14684184
references: J Cell Sci. 2008 Aug 15;121(Pt 16):2685-95
references: 18653543
references: Nat Rev Mol Cell Biol. 2009 Jul;10(7):458-67
references: 19491929
references: EMBO J. 2006 May 3;25(9):1945-56
references: 16619030
references: J Cell Biol. 2000 Oct 30;151(3):551-62
references: 11062257
references: Trends Cell Biol. 2003 Mar;13(3):137-45
references: 12628346
references: Nature. 2006 Jun 15;441(7095):880-4
references: 16625205
references: J Biol Chem. 1998 Jun 5;273(23):14484-94
references: 9603962
references: FEBS Lett. 2010 Apr 2;584(7):1374-8
references: 20153326
references: Science. 2001 May 25;292(5521):1552-5
references: 11375494
references: Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9402-7
references: 10944212
references: J Biol Chem. 2001 Sep 21;276(38):35334-43
references: 11445583
references: Int J Biochem Cell Biol. 2005 Oct;37(10):1933-7
references: 16125107
references: Nature. 2006 Jun 15;441(7095):885-9
references: 16625204
references: EMBO J. 2009 Apr 8;28(7):889-901
references: 19229298
references: Cell Death Differ. 2011 Apr;18(4):571-80
references: 21311563
references: J Biol Chem. 2004 Nov 12;279(46):47704-10
references: 15355958
references: Curr Biol. 1996 Jun 1;6(6):662-5
references: 8793288
references: Cell. 1994 Sep 9;78(5):761-71
references: 8087844
references: Nature. 2010 Sep 9;467(7312):179-84
references: 20829789
references: Eur J Biochem. 1989 Nov 6;185(2):469-74
references: 2555193
references: Cell Metab. 2007 Dec;6(6):472-83
references: 18054316
references: J Cell Sci. 2004 Sep 15;117(Pt 20):4837-48
references: 15340014
references: J Biol Chem. 2008 Jan 18;283(3):1437-1444
references: 18006506
references: EMBO J. 2005 Oct 19;24(20):3602-12
references: 16193061
references: Nat Rev Mol Cell Biol. 2007 Sep;8(9):741-52
references: 17717517
references: Nat Rev Mol Cell Biol. 2009 Oct;10(10):659-71
references: 19773779
references: Nat Rev Mol Cell Biol. 2011 Oct 21;12(11):735-47
references: 22016057
references: J Biol Chem. 2007 Aug 17;282(33):24131-45
references: 17580304
references: Cell Res. 2010 Jul;20(7):748-62
references: 20548331
references: J Biol Chem. 1984 Dec 10;259(23):14835-9
references: 6501319
references: Traffic. 2007 Dec;8(12):1657-1667
references: 17897320
references: Nat Cell Biol. 2006 Jul;8(7):688-99
references: 16799551
references: Drug Resist Updat. 2010 Jun;13(3):87-92
references: 20462785
references: Curr Opin Cell Biol. 1995 Apr;7(2):215-23
references: 7612274
references: EMBO J. 2010 Jun 2;29(11):1792-802
references: 20418806
references: Eur J Biochem. 1995 Feb 1;227(3):792-800
references: 7867640
references: Am J Pathol. 2007 Aug;171(2):513-24
references: 17620365
references: Nature. 2009 Mar 26;458(7237):445-52
references: 19325624
references: Cell Metab. 2007 Dec;6(6):458-71
references: 18054315
references: Panminerva Med. 2010 Mar;52(1):9-25
references: 20228723
references: Cell. 2004 Apr 30;117(3):399-412
references: 15109499
references: Trends Cell Biol. 2010 Jun;20(6):355-62
references: 20356743
references: Hum Mol Genet. 2002 May 1;11(9):1107-17
references: 11978769
references: Biogerontology. 2011 Oct;12(5):377-86
references: 21347677
references: Hum Mol Genet. 2008 Feb 1;17(3):431-9
references: 17981811
references: ScientificWorldJournal. 2010 Aug 03;10:1543-52
references: 20694452
references: Protein Cell. 2010 Oct;1(10):907-15
references: 21204017
references: Autophagy. 2009 Jul;5(5):732-3
references: 19398892
references: Autophagy. 2009 Jul;5(5):663-75
references: 19337030
references: Vet Pathol. 2011 Jan;48(1):245-53
references: 21062910
references: J Cell Sci. 2011 Aug 15;124(Pt 16):2692-701
references: 21771882
references: Mol Cell. 2004 Nov 19;16(4):575-86
references: 15546617
references: Mol Cell Proteomics. 2008 Dec;7(12):2419-28
references: 18687634
references: Semin Cell Dev Biol. 2004 Feb;15(1):3-16
references: 15036202
references: J Biomed Biotechnol. 2006;2006(3):62079
references: 17047309
references: Autophagy. 2010 Apr;6(3):330-44
references: 20168092
references: Autophagy. 2008 Apr;4(3):378-80
references: 18227643
references: Mol Cell Biol. 2004 Sep;24(18):8055-68
references: 15340068
references: Int J Biochem Cell Biol. 2003 May;35(5):606-16
references: 12672453
references: J Biol Chem. 2001 Jan 19;276(3):2083-7
references: 11085977
references: Mol Biol Cell. 2008 May;19(5):2092-100
references: 18321988
references: Ageing Res Rev. 2009 Jul;8(3):199-213
references: 19427410
references: Cell Death Differ. 2007 Feb;14(2):230-9
references: 16794605
references: Cell Stress Chaperones. 2003 Winter;8(4):303-8
references: 15115282
references: Annu Rev Cell Dev Biol. 2002;18:575-99
references: 12142265
references: Cell Mol Life Sci. 2012 Apr;69(7):1125-36
references: 22080117
references: Nat Rev Mol Cell Biol. 2011 Dec 14;13(1):7-12
references: 22166994
references: Biochim Biophys Acta. 2004 Nov 29;1695(1-3):55-72
references: 15571809
references: J Biol Chem. 1995 May 12;270(19):11623-7
references: 7744802
references: Physiol Rev. 2010 Oct;90(4):1383-435
references: 20959619
references: Cell. 1999 Mar 5;96(5):635-44
references: 10089879
references: Cell. 2006 Jul 14;126(1):121-34
references: 16839881
references: J Neurochem. 2009 Nov;111(3):801-7
references: 19712056
references: Mol Cell Biol. 2006 Dec;26(24):9220-31
references: 17030611
references: Nat Rev Mol Cell Biol. 2001 Mar;2(3):211-6
references: 11265251
references: J Exp Med. 1998 Jan 5;187(1):97-104
references: 9419215
references: Autophagy. 2011 Mar;7(3):279-96
references: 21189453
references: J Cell Biol. 1998 Dec 28;143(7):1883-98
references: 9864362
references: Autophagy. 2011 Dec;7(12):1448-61
references: 22082875
references: J Natl Cancer Inst. 2011 Jul 6;103(13):1007-17
references: 21606441
references: J Biol Chem. 2005 Jun 24;280(25):23727-34
references: 15845543
references: Int Rev Cell Mol Biol. 2008;267:59-124
references: 18544497
references: Genes Dev. 1998 Apr 1;12(7):901-7
references: 9531529
references: Cancer Lett. 2010 Jul 1;293(1):15-22
references: 20133049
references: J Biol Chem. 2003 Jul 4;278(27):25009-13
references: 12719433
references: Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a006734
references: 21068151
references: Cell Cycle. 2010 May 15;9(10):1901-6
references: 20495377
references: Cell Mol Life Sci. 2007 Oct;64(19-20):2525-41
references: 17565442
references: Free Radic Biol Med. 2002 Sep 1;33(5):611-9
references: 12208347
references: Annu Rev Biochem. 1998;67:425-79
references: 9759494
references: Mol Cell. 2010 Oct 22;40(2):238-52
references: 20965419