title: Propranolol-resistant infantile haemangiomas.
abstract: BACKGROUND
  Propranolol is now widely used to treat severe infantile haemangiomas (IHs). Very few cases of propranolol-resistant IH (PRIH) are mentioned in the literature.
  
  
  OBJECTIVE
  To describe the characteristics of PRIHs.
  
  
  METHODS
  A national, multicentre, retrospective, observational study was conducted from February 2011 to December 2011. All patients with PRIH evaluated by the members of the Groupe de Recherche Clinique en Dermatologie Pédiatrique from 1 January 2007 to 1 December 2011 were eligible.
  
  
  RESULTS
  Among 1130 patients treated with propranolol for infantile haemangioma, 10 (0.9%) had PRIHs. Haemangioma propranolol resistance was observed at all ages during early childhood and at any proliferation stage.
  
  
  CONCLUSIONS
  PRIH is a rare phenomenon that raises questions and merits further investigation.
authors: Department of Dermatology, Centre Hospitalier Universitaire Hôtel-Dieu, 1 place Alexis-Ricordeau, 44093 Nantes Cedex 1, France.
authors: S
authors: S
authors: Caussé
authors: H
authors: H
authors: Aubert
authors: M
authors: M
authors: Saint-Jean
authors: E
authors: E
authors: Puzenat
authors: A-C
authors: AC
authors: Bursztejn
authors: C
authors: C
authors: Eschard
authors: E
authors: E
authors: Mahé
authors: A
authors: A
authors: Maruani
authors: J
authors: J
authors: Mazereeuw-Hautier
authors: I
authors: I
authors: Dreyfus
authors: J
authors: J
authors: Miquel
authors: C
authors: C
authors: Chiaverini
authors: O
authors: O
authors: Boccara
authors: S
authors: S
authors: Hadj-Rabia
authors: J-F
authors: JF
authors: Stalder
authors: S
authors: S
authors: Barbarot
mesh_terms: D017668:Age of Onset; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D019008:Drug Resistance, Neoplasm; D005153:Facial Neoplasms / Q000188:drug therapy*; D005260:Female; D006391:Hemangioma / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D009918:Orbital Neoplasms / Q000188:drug therapy*; D011433:Propranolol / Q000627:therapeutic use*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D011433:Propranolol