title: Cytotoxic constituents from Psoralea corylifolia.
abstract: Bioassay directed isolation of the EtOAc extract from a traditional Chinese medicine Psoralea corylifolia resulted in the purification of two isoflavonoids, corylifols D (1) and E (2), along with four known ones. The structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. When tested against HepG2 and Hep3B hepatocellular carcinoma cell lines, corylifol A (4) displayed IC50 values of 4.6 and 13.5 μg/ml, respectively.
authors: College of Chemistry and Life Sciences, Qinghai University for Nationalities, Xiling 810007, China.
authors: Ping
authors: P
authors: Song
authors: Xin-Zhou
authors: XZ
authors: Yang
authors: Jing-Quan
authors: JQ
authors: Yuan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011564:Furocoumarins / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D029907:Psoralea / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D011564:Furocoumarins; D007529:Isoflavones; C583107:corylifol D; C583108:corylifol E