title: The quest for myelin in the adult brain.
abstract: Although myelination largely occurs during early postnatal life, myelinating oligodendrocytes are still generated in the adult brain. Myelin turnover in the adult is necessary for proper neuronal function and is gravely compromised in myelin disorders. The lineage relationship between adult neural stem cells and adult-born oligodendrocytes has been clarified, highlighting molecular pathways that could potentially be targeted to favour de novo myelination in pathological situations.
authors: Emanuela
authors: E
authors: Zuccaro
authors: Paola
authors: P
authors: Arlotta
mesh_terms: D000818:Animals; D019070:Cell Lineage; D005260:Female; D008297:Male; D058953:Neural Stem Cells / Q000166:cytology* / Q000378:metabolism*; D009836:Oligodendroglia / Q000166:cytology* / Q000378:metabolism*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000096:biosynthesis*; D056564:Sirtuin 1 / Q000037:antagonists & inhibitors*
chemical_list: D020796:Receptor, Platelet-Derived Growth Factor alpha; C470545:Sirt1 protein, mouse; D056564:Sirtuin 1
references: Curr Top Microbiol Immunol. 2008;318:193-212
references: 18219819
references: Physiol Rev. 2001 Apr;81(2):871-927
references: 11274346
references: Nat Rev Neurosci. 2008 Nov;9(11):839-55
references: 18931697
references: Adv Exp Med Biol. 2012;724:154-71
references: 22411242
references: Nat Cell Biol. 2013 Jun;15(6):614-24
references: 23644469
references: Nat Cell Biol. 2013 Jun;15(6):602-13
references: 23644466
references: Curr Opin Neurol. 2008 Jun;21(3):235-41
references: 18451704
references: Biochim Biophys Acta. 2013 Feb;1830(2):2435-48
references: 22982587
references: Development. 2011 Mar;138(6):1057-68
references: 21343361
references: Annu Rev Neurosci. 2009;32:149-84
references: 19555289
references: Science. 2007 Jul 20;317(5836):381-4
references: 17615304
references: J Neurochem. 2008 Oct;107(1):1-19
references: 18643793