title: Dual enzyme responsive microcapsules simulating an "OR" logic gate for biologically triggered drug delivery applications.
abstract: Hollow microcapsules capable of disintegrating in response to dual biological stimuli have been synthesized from two FDA approved drug molecules. The capsules fabricated from protamine and chondroitin sulphate disintegrate in the presence of either trypsin or hyaluronidase enzymes, which are documented to be simultaneously over-expressed under some pathological conditions.
authors: Department of Materials Engineering, Indian Institute of Science, Bangalore, 560012, India.
authors: Krishna
authors: K
authors: Radhakrishnan
authors: Jasaswini
authors: J
authors: Tripathy
authors: Ashok M
authors: AM
authors: Raichur
mesh_terms: D002119:Calcium Carbonate / Q000737:chemistry; D002214:Capsules; D002809:Chondroitin Sulfates / Q000737:chemistry*; D016503:Drug Delivery Systems; D006821:Hyaluronoglucosaminidase / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry; D011479:Protamines / Q000737:chemistry*; D014357:Trypsin / Q000737:chemistry*
chemical_list: D002214:Capsules; D011137:Polystyrenes; D011479:Protamines; C003321:polystyrene sulfonic acid; D002809:Chondroitin Sulfates; D006821:Hyaluronoglucosaminidase; D014357:Trypsin; D002119:Calcium Carbonate