title: Comment on "Evidence of abundant purifying selection in humans for recently acquired regulatory functions".
abstract: Ward and Kellis (Reports, 28 September 2012, p. 1675; published online 5 September 2012) found altered patterns of human polymorphism in biochemically active but non-mammalian-conserved genomic regions relative to control regions and interpreted this as due to lineage-specific purifying selection. We find on closer inspection of their data that the polymorphism trends are primarily attributable to mutational variation and technical artifacts rather than selection.
authors: Genome Sciences Department, University of Washington, Seattle, WA 98195, USA. phg@uw.edu
authors: Phil
authors: P
authors: Green
authors: Brent
authors: B
authors: Ewing
mesh_terms: D005786:Gene Expression Regulation; D014644:Genetic Variation; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D012641:Selection, Genetic