title: A new method to estimate parameters of the growth model for metastatic tumours.
abstract: OBJECTIVE
  Knowledge of natural tumour growth is valuable for understanding tumour biology, optimising screening programs, prognostication, optimal scheduling of chemotherapy, and assessing tumour spread. However, mathematical modelling in individuals is hampered by the limited data available. We aimed to develop a method to estimate parameters of the growth model and formation rate of metastases in individual patients.
  
  
  METHODS
  Data from one patient with liver metastases from a primary ileum carcinoid and one patient with lung metastases from a primary renal cell carcinoma were used to demonstrate this new method. Metastatic growth models were estimated by direct curve fitting, as well as with the new proposed method based on the relationship between tumour growth rate and tumour volume. The new model was derived from the Gompertzian growth model by eliminating the time factor (age of metastases), which made it possible to perform the calculations using data from all metastases in each patient. Finally, the formation time of each metastasis and, consecutively, the formation rate of metastases in each patient were estimated.
  
  
  RESULTS
  With limited measurements in clinical studies, fitting different growth curves was insufficient to estimate true tumour growth, even if patients were followed for several years. Growth of liver metastases was well described with a general growth model for all metastases. However, the lung metastases from renal cell carcinoma were better described by heterogeneous exponential growth with various growth rates.
  
  
  CONCLUSIONS
  Analysis of the regression of tumour growth rate with the logarithm of tumour volume can be used to estimate parameters of the tumour growth model and metastasis formation rates, and therefore the number and size distribution of metastases in individuals.
authors: Department of Radiation Physics, University of Gothenburg, Sahlgrenska University Hospital, Göteborg, SE - 413 45, Sweden. e.mehrara@radfys.gu.se
authors: Esmaeil
authors: E
authors: Mehrara
authors: Eva
authors: E
authors: Forssell-Aronsson
authors: Viktor
authors: V
authors: Johanson
authors: Lars
authors: L
authors: Kölby
authors: Ragnar
authors: R
authors: Hultborn
authors: Peter
authors: P
authors: Bernhardt
mesh_terms: D002292:Carcinoma, Renal Cell / Q000473:pathology*; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology*; D007680:Kidney Neoplasms / Q000473:pathology*; D008113:Liver Neoplasms / Q000556:secondary*
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