title: Neuromodulation device therapy for treatment of hypertensive heart disease.
abstract: Hypertensive heart disease (HHD) is the leading cause of mortality and morbidity in the United States. Despite the availability of medical therapy it remains a challenge to treat. Autonomic nervous system imbalance resulting in overactivity of the sympathetic nervous system and under activity of the parasympathetic nervous system is integral in the development of hypertension and ultimately the development of HHD. Emerging data suggest that neuromodulation device therapy for treatment of HHD is promising.
authors: Division of Cardiology, Medical University of South Carolina, Charleston, SC, USA. todoran@musc.edu
authors: Thomas M
authors: TM
authors: Todoran
authors: Michael R
authors: MR
authors: Zile
mesh_terms: D006331:Heart Diseases / Q000401:mortality / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D006973:Hypertension / Q000401:mortality / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D010275:Parasympathetic Nervous System / Q000473:pathology / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000473:pathology / Q000503:physiopathology; D014481:United States; D055536:Vagus Nerve Stimulation / Q000295:instrumentation* / Q000379:methods*