title: Deubiquitinases as potential anti-cancer targets for gold(III) complexes.
abstract: A panel of [Au(III)(C^N)(R2NCS2)](+) (HC^N = 2-phenylpyridine) complexes displayed significant deubiquitinases (DUBs) inhibitory activity; one of these complexes showed selective in vitro cytotoxicity towards breast cancer cells correlated to high cellular uptake of gold, and induced cell-cycle arrest, apoptosis, and anti-angiogenic property that could be related to DUB inhibitory activity.
authors: Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors: Jing-Jing
authors: JJ
authors: Zhang
authors: Kwan-Ming
authors: KM
authors: Ng
authors: Chun-Nam
authors: CN
authors: Lok
authors: Raymond Wai-Yin
authors: RW
authors: Sun
authors: Chi-Ming
authors: CM
authors: Che
mesh_terms: D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000201:enzymology; D045744:Cell Line, Tumor; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D050607:Organogold Compounds / Q000737:chemistry* / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D043222:Ubiquitin Thiolesterase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D050607:Organogold Compounds; D011725:Pyridines; C482860:UCHL1 protein, human; C058324:2-phenylpyridine; C509806:UCHL3 protein, human; C421245:UCHL5 protein, human; D043222:Ubiquitin Thiolesterase; D003546:Cysteine Endopeptidases