title: Suicide attempts and clinical risk factors in patients with bipolar and unipolar affective disorders.
abstract: BACKGROUND
  Suicide is an important clinical problem in psychiatric patients. The highest risk of suicide attempts is noted in affective disorders.
  
  
  OBJECTIVE
  The aim of the study was to look for suicide risk factors among sociodemographic and clinical factors, family history and stressful life events in patients with diagnosis of unipolar and bipolar affective disorder (597 patients, 563 controls).
  
  
  METHODS
  In the study, the Structured Clinical Interview for DSM-IV Axis I Disorders and the Operational Criteria Diagnostic Checklist questionnaires, a questionnaire of family history, and a questionnaire of personality disorders and life events were used.
  
  
  RESULTS
  In the bipolar and unipolar affective disorders sample, we observed an association between suicidal attempts and the following: family history of psychiatric disorders, affective disorders and psychoactive substance abuse/dependence; inappropriate guilt in depression; chronic insomnia and early onset of unipolar disorder. The risk of suicide attempt differs in separate age brackets (it is greater in patients under 45 years old). No difference in family history of suicide and suicide attempts; marital status; offspring; living with family; psychotic symptoms and irritability; and coexistence of personality disorder, anxiety disorder or substance abuse/dependence with affective disorder was observed in the groups of patients with and without suicide attempt in lifetime history.
authors: Laboratory of Psychiatric Genetics, Department of Psychiatry, University of Medical Sciences, ul Szpitalna 27/33, 60-572 Poznan, Poland. joanna.pawlak@gmail.com
authors: Joanna
authors: J
authors: Pawlak
authors: Monika
authors: M
authors: Dmitrzak-Węglarz
authors: Maria
authors: M
authors: Skibińska
authors: Aleksandra
authors: A
authors: Szczepankiewicz
authors: Anna
authors: A
authors: Leszczyńska-Rodziewicz
authors: Aleksandra
authors: A
authors: Rajewska-Rager
authors: Dorota
authors: D
authors: Zaremba
authors: Piotr
authors: P
authors: Czerski
authors: Joanna
authors: J
authors: Hauser
mesh_terms: D000293:Adolescent; D000328:Adult; D000341:Affective Disorders, Psychotic / Q000453:epidemiology / Q000235:genetics; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001008:Anxiety Disorders / Q000453:epidemiology; D001714:Bipolar Disorder / Q000453:epidemiology* / Q000235:genetics; D015897:Comorbidity; D003866:Depressive Disorder / Q000453:epidemiology* / Q000235:genetics; D005190:Family; D005260:Female; D006167:Guilt; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000453:epidemiology / Q000235:genetics; D010554:Personality Disorders / Q000453:epidemiology; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000235:genetics; D013406:Suicide, Attempted / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires; D055815:Young Adult