title: Polymorphisms in the activin A receptor type 2A gene affect the onset time and severity of preeclampsia in the Turkish population.
abstract: OBJECTIVE
  To investigate the possible roles of selected single nucleotide gene polymorphisms (SNPs) of the activin A receptor type 2A (ACVR2A) gene in the pathogenesis of preeclampsia.
  
  
  METHODS
  Ninety-four patients with preeclampsia and 166 healthy pregnant women were included in this study. Genomic DNA was extracted from venous blood and were stored at -80°C before the analysis. Selected ACVR2A SNPs (rs10497025, rs1128919, rs13430086) were determined in an ABI 7900 HT Real-Time PCR instrument.
  
  
  RESULTS
  For all three SNPs, no statistically significant difference was found between preeclampsia and control groups in terms of genotype and allele frequencies. In the late preeclampsia group, with regard to the rs1128919 SNP, the frequency of GG genotype was found to be significantly lower (P=0.02). Although the frequency of "A" allele was found to be higher (P=0.05; OR=1.54), and the "G" allele was found to be lower (P=0.05; OR=0.65), the results did not reach statistical significance in late preeclamptic patients. For the rs1128919 SNP, the frequency of the AA genotype was found to be significantly higher in both mild (P=0.004) and severe (P=0.0001) preeclampsia groups, whereas the frequency of GG genotype was found to be significantly lower (P=0.008, and P=0.0001, respectively). For the rs13430086 SNP, while the frequency of the AA genotype was found to be significantly lower in both mild (P=0.02) and severe (P=0.0001) preeclamptic patients, the frequency of TT genotype was found to be significantly higher in only severe preeclampsia group (P=0.0001).
  
  
  CONCLUSIONS
  ACVR2A gene polymorphisms may play a role in the development of preeclampsia.
authors: Department of Obstetrics and Gynecology, Ege University School of Medicine, Bornova, Izmir 35100, Turkey. bzeybek@yahoo.com
authors: Burak
authors: B
authors: Zeybek
authors: Handan Ak
authors: HA
authors: Celik
authors: Hikmet Hakan
authors: HH
authors: Aydin
authors: Niyazi
authors: N
authors: Askar
mesh_terms: D030301:Activin Receptors, Type II / Q000235:genetics*; D000328:Adult; D001724:Birth Weight; D001794:Blood Pressure; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D011247:Pregnancy; D012720:Severity of Illness Index; D013997:Time Factors; D014421:Turkey; D055815:Young Adult
chemical_list: D030301:Activin Receptors, Type II; C425585:activin receptor type II-A