title: Quantitative approaches to uncover physical mechanisms of tissue morphogenesis.
abstract: Morphogenesis, the creation of tissue and organ architecture, is a series of complex and dynamic processes driven by genetic programs, microenvironmental cues, and intercellular interactions. Elucidating the physical mechanisms that generate tissue form is key to understanding development, disease, and the strategies needed for regenerative therapies. Advancements in imaging technologies, genetic recombination techniques, laser ablation, and microfabricated tissue models have enabled quantitative descriptions of the cellular motions and tissue deformations and stresses with unprecedented temporal and spatial resolution. Using these data synergistically with increasingly more sophisticated physical, mathematical, and computational models will unveil the physical mechanisms that drive morphogenesis.
authors: Department of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
authors: Jason P
authors: JP
authors: Gleghorn
authors: Sriram
authors: S
authors: Manivannan
authors: Celeste M
authors: CM
authors: Nelson
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002468:Cell Physiological Phenomena; D058948:Cell Tracking; D003198:Computer Simulation; D008954:Models, Biological; D009024:Morphogenesis / Q000235:genetics; D013997:Time Factors
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