title: Klebsiella pneumoniae harbouring OXA-48 carbapenemase in a Libyan refugee in Italy.
abstract: A carbapenem-resistant Klebsiella pneumoniae was isolated from a blood-culture of an inpatient from Libya, hospitalized in the intensive-care unit of Negrar Hospital, Italy. The clinical isolate carried the following β-lactamase genes, bla(TEM -1), bla(SHV -11), bla(OXA -1), bla(CTX -M-15) and bla(OXA -48), respectively. The bla(OXA -48) gene was inserted in the Tn1999.2 transposon type, carried on a conjugative, 60-kilobase plasmid, that presented an L/M backbone, hosted by a multidrug-resistant ST 101 K. pneumoniae strain. Our report highlights the international transfer of bla(OXA -48) gene and the importance of screening measures of multidrug-resistant Enterobacteriaceae.
authors: Department of Pathology and Diagnostics, University of Verona, Verona, Italy.
authors: E
authors: E
authors: Kocsis
authors: C
authors: C
authors: Savio
authors: M
authors: M
authors: Piccoli
authors: G
authors: G
authors: Cornaglia
authors: A
authors: A
authors: Mazzariol
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015780:Carbapenems / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006801:Humans; D007297:Inpatients; D007362:Intensive Care Units; D007558:Italy; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification*; D008002:Libya / Q000208:ethnology; D008297:Male; D008826:Microbial Sensitivity Tests; D012036:Refugees; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D001618:beta-Lactamases; C108449:oxacillinase
keywords: IncL/M-like plasmid; Klebsiella pneumoniae ST 101; OXA-48; Tn1999.2; carbapenem resistance