title: A universal biosensor for multiplex DNA detection based on hairpin probe assisted cascade signal amplification.
abstract: A hairpin DNA probe mediated cascade signal amplification method was developed for visual and rapid DNA analysis with a detection limit of 100 aM. The implementation of tag/anti-tag DNA and gold nanoparticle reporters permits a universal platform for multiplex genotyping without instrumentation.
authors: Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
authors: Jie
authors: J
authors: Liu
authors: Lingbo
authors: L
authors: Chen
authors: Puchang
authors: P
authors: Lie
authors: Boying
authors: B
authors: Dun
authors: Lingwen
authors: L
authors: Zeng
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D019921:Biotinylation; D004247:DNA / Q000032:analysis* / Q000235:genetics; D015342:DNA Probes / Q000737:chemistry / Q000235:genetics; D004867:Equipment Design; D060005:Genotyping Techniques / Q000295:instrumentation*; D006046:Gold / Q000737:chemistry; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry
chemical_list: D015342:DNA Probes; D006046:Gold; D004247:DNA