title: A Newborn with Congenital Mixed Phenotype Acute Leukemia After In Vitro Fertilization.
abstract: Congenital leukemia is a rare disease. The majority of cases of this disease are acute myelogenous leukemia (AML). Congenital acute lymphoblastic leukemia (ALL) is rare and most often is of B cell lineage. Rarely, some cases have been designated biphenotypic or mixed phenotype acute leukemia (MPAL). Herein, we report a preterm newborn referred to us as a result of the appearance of blue-violaceous dermal nodules on her body at birth. She was a twin and the product of an in vitro fertilization (IVF) pregnancy. Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules. Bone marrow aspiration showed 40% blasts of lymphoid lineage; skin biopsy and its immunohistochemistry revealed myeloblastic infiltration of the dermis. Cytogenetic analysis (46,XX), fluorescence in situ hybridization (FISH) analysis, and cranial magnetic resonance were normal. The patient was diagnosed with congenital MPAL, and an association between IVF and congenital leukemia was suggested.
authors: Department of Pediatrics, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors: Hacer
authors: H
authors: Ergin
authors: Department of Pediatrics, Faculty of Medicine, Pamukkale University, Denizli, Turkey. Electronic address: drozmert@gmail.com.
authors: Özmert M A
authors: ÖM
authors: Özdemir
authors: Department of Pediatrics, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors: Abdullah
authors: A
authors: Karaca
authors: Department of Pathology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors: Nilay Şen
authors: NŞ
authors: Türk
authors: Department of Clinical Genetics, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors: Füsun
authors: F
authors: Düzcan
authors: Department of Dermatology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
authors: Şeniz
authors: Ş
authors: Ergin
authors: Department of Pediatric Hematology-Oncology, Behçet Uz Pediatric Hospital, İzmir, Turkey.
authors: Elif
authors: E
authors: Kazancı
authors: Department of Pediatric Hematology-Oncology, Behçet Uz Pediatric Hospital, İzmir, Turkey.
authors: Canan
authors: C
authors: Vergin
authors: Department of Pediatric Hematology-Oncology, Behçet Uz Pediatric Hospital, İzmir, Turkey.
authors: Ayşe
authors: A
authors: Erbay
mesh_terms: D004200:Diseases in Twins / Q000235:genetics* / Q000276:immunology; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007231:Infant, Newborn; D007234:Infant, Premature; D015456:Leukemia, Biphenotypic, Acute / Q000151:congenital* / Q000276:immunology; D012878:Skin Neoplasms / Q000151:congenital* / Q000276:immunology
keywords: congenital; in vitro fertilization (IVF); leukemia cutis; mixed phenotype acute leukemia (MPAL)