title: Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis elegans.
abstract: BACKGROUND
  Selenium is an essential micronutrient that has a narrow exposure window between its beneficial and toxic effects. This study investigated the protective potential of selenite (IV) against lead (Pb(II))-induced neurotoxicity in Caenorhabditis elegans.
  
  
  RESULTS
  The results showed that Se(IV) (0.01 µM) pretreatment ameliorated the decline of locomotion behaviors (frequencies of body bends, head thrashes, and reversal ) of C. elegans that are damaged by Pb(II) (100 µM) exposure. The intracellular ROS level of C. elegans induced by Pb(II) exposure was significantly lowered by Se(IV) supplementation prior to Pb(II) exposure. Finally, Se(IV) protects AFD sensory neurons from Pb(II)-induced toxicity.
  
  
  CONCLUSIONS
  Our study suggests that Se(IV) has protective activities against Pb(II)-induced neurotoxicity through its antioxidant property.
authors: Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan.
authors: Wen-Hsuan
authors: WH
authors: Li
authors: Yeu-Ching
authors: YC
authors: Shi
authors: I-Ling
authors: IL
authors: Tseng
authors: Vivian Hsiu-Chuan
authors: VH
authors: Liao
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D019610:Cytoprotection / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism; D007854:Lead / Q000633:toxicity*; D008124:Locomotion / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009498:Neurotoxins / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000378:metabolism; D018038:Sodium Selenite / Q000494:pharmacology*
chemical_list: D029742:Caenorhabditis elegans Proteins; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D009498:Neurotoxins; D012333:RNA, Messenger; D017382:Reactive Oxygen Species; D007854:Lead; D018038:Sodium Selenite
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