title: Magnetic and photoresponsive theranosomes: translating cell-released vesicles into smart nanovectors for cancer therapy.
abstract: Cell-released vesicles are natural carriers that circulate in body fluids and transport biological agents to distal cells. As nature uses vesicles in cell communication to promote tumor progression, we propose to harness their unique properties and exploit these biogenic carriers as Trojan horses to deliver therapeutic payloads to cancer cells. In a theranostic approach, cell-released vesicles were engineered by a top-down procedure from precursor cells, previously loaded with a photosensitizer and magnetic nanoparticles. The double exogenous cargo provided vesicles with magnetic and optical responsiveness allowing therapeutic and imaging functions. This new class of cell-derived smart nanovectors was named "theranosomes". Theranosomes enabled efficient photodynamic tumor therapy in a murine cancer model in vivo. Moreover the distribution of this biogenic vector could be monitored by dual-mode imaging, combining fluorescence and MRI. This study reports the first success in translating a cell communication mediator into a smart theranostic nanovector.
authors: Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and Université Paris Diderot , 10 Rue Alice Domon et Léonie Duquet, 75205 Paris Cedex 13, France.
authors: Amanda K A
authors: AK
authors: Silva
authors: Jelena
authors: J
authors: Kolosnjaj-Tabi
authors: Stephanie
authors: S
authors: Bonneau
authors: Iris
authors: I
authors: Marangon
authors: Nicole
authors: N
authors: Boggetto
authors: Kelly
authors: K
authors: Aubertin
authors: Olivier
authors: O
authors: Clément
authors: Michel Francis
authors: MF
authors: Bureau
authors: Nathalie
authors: N
authors: Luciani
authors: Florence
authors: F
authors: Gazeau
authors: Claire
authors: C
authors: Wilhelm
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism*; D005260:Female; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008279:Magnetic Resonance Imaging; D059346:Magnets; D008297:Male; D008652:Mesoporphyrins / Q000737:chemistry / Q000627:therapeutic use; D051379:Mice; D049329:Nanostructures; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy
chemical_list: D004337:Drug Carriers; D008652:Mesoporphyrins; D017319:Photosensitizing Agents; C072269:temoporfin