title: [Evaluating adaptogenic properties of Rhodiola rosea extract in human mononuclear cell culture and rat tissues].
abstract: The administration of various doses of Rhodiola rosea roots and rhizome spissum with known concentrations of salidroside, n-tyrosol, and rosavine leads to an increase in stress proteins 70 content in human mononuclear cell culture and in tissues of Wistar rats. A one-week peroral administration of Rh. Rosea preparation increases the content of constitutive Hsc70 in liver and the amount of hepatocytes with low succinate dehydrogenase activity. A two-week administration of Rh. Rosea extract leads to an increase in the levels of inducible Hsp70 and constitutive Hsc70 proteins in liver, hippocampus and left heart ventricle. These results are indicative of an increase in nonspecific resistance and the activation of adaptogenic processes.
authors: L I
authors: LI
authors: Andreeva
authors: A A
authors: AA
authors: Boĭkova
authors: D V
authors: DV
authors: Nikiforova
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D015870:Gene Expression / Q000187:drug effects; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D006352:Heart Ventricles / Q000187:drug effects / Q000378:metabolism; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D029771:Rhodiola / Q000737:chemistry*; D013385:Succinate Dehydrogenase / Q000235:genetics / Q000378:metabolism
chemical_list: D018840:HSP70 Heat-Shock Proteins; D010936:Plant Extracts; D013385:Succinate Dehydrogenase