title: Use of hyperspectral imaging for label-free decoding and detection of biomarkers.
abstract: Detecting the existence of biomarkers is one of the most important issues in molecular diagnosis. This Letter presents a label-free decoding and detection method for biomarker tests based on hyperspectral imaging and interferometry. The decoding and detection results were extracted from a single hyperspectral image with different spectrum-to-thickness reconstructing algorithms, which made the testing procedure extremely fast and simple. The coding capacity of this method is more than 400, and the detection sensitivity can reach 2 ng/mm2 without fluorescent labeling.
authors: Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing 100084, China.
authors: Tongzhou
authors: T
authors: Wang
authors: Qiang
authors: Q
authors: Li
authors: Xin
authors: X
authors: Li
authors: Songmin
authors: S
authors: Zhao
authors: Ying
authors: Y
authors: Lu
authors: Guoliang
authors: G
authors: Huang
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007368:Interferometry; D057054:Molecular Imaging / Q000379:methods*
chemical_list: D015415:Biomarkers; D007074:Immunoglobulin G