title: [Analysis of association between the IRF5 gene single nucleotide polymorphism and allergic rhinitis].
abstract: OBJECTIVE
  To study the possible association between interferon regulatory factor 5 (IRF5) gene polymorphism and allergic rhinitis (AR).
  
  
  METHODS
  Six independent single nucleotide polymorphism (SNP, rs729302, rs4728142, rs3807306, rs2070197, rs11770589, rs2280714) were analyzed. The genotype and allele frequencies were detected in 110 AR patients and 101 healthy controls in Singapore Chinese population by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).
  
  
  RESULTS
  Rs729302 was rejected as it was not polymorphic. For others SNP, no statistically significant difference was detected in genotype between AR and healthy control group (χ(2) value were 0.21, 5.02, 0.01, 2.91, 0.37, all P > 0.05). No statistically significant difference was detected in allele frequencies between AR and healthy control group (χ(2) value were 0.00, 2.78, 0.01, 2.31, 0.00, all P > 0.05).
  
  
  CONCLUSIONS
  No association is observed between IRF5 and AR in Singapore Chinese population.
authors: Department of Otorhinolaryngology, People's Hospital of Shanghai Putuo District, Shanghai 200060, China.
authors: Hui-jie
authors: HJ
authors: Feng
authors: Wen-xiu
authors: WX
authors: Li
authors: Su-juan
authors: SJ
authors: Bai
authors: De-yun
authors: DY
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics*; D012846:Singapore; D055815:Young Adult
chemical_list: C431713:IRF5 protein, human; D050835:Interferon Regulatory Factors