title: A combination of a dairy product fermented by lactobacilli and galactooligosaccharides shows additive effects on mineral balances in growing rats with hypochlorhydria induced by a proton pump inhibitor.
abstract: This study aimed to investigate the effects of a combination of a dairy product fermented by lactobacilli (DFL) and galactooligosaccharides (GOS) on mineral balances in growing rats with hypochlorhydria induced by a proton pump inhibitor (PPI). Three-week-old male rats were assigned to receive one of six diets: a control diet, control diets containing 1.6 or 5.0 % GOS, a DFL diet and DFL diets containing 1.6 or 5.0 % GOS for 9 days. From day 5 of the feeding period, half of the rats fed with control diets were subcutaneously administered with saline, whereas the remaining rats were administered with PPI for 5 days. Calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe) and zinc (Zn) balances were determined from days 6 to 9. PPI administration significantly decreased the apparent absorption of Ca and Fe and increased urinary P excretion, resulting in decreased Ca, Fe and P retention. GOS dose-dependently increased the apparent absorption of Ca, Mg and Fe and urinary Mg excretion and decreased urinary P excretion. DFL significantly increased the apparent absorption of Ca and Mg and urinary Mg excretion. The combination of DFL and GOS additively affected these parameters, resulting in increased Ca, P and Fe retention, and it further increased the apparent absorption and retention of Zn at 5.0 % GOS. In conclusion, the combination of DFL and GOS improves Ca, P and Fe retention in an additive manner and increases the Zn retention in growing rats with hypochlorhydria induced by PPI.
authors: Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., 540 Naruda, Odawara, Kanagawa 250-0862, Japan. satoshi.takasugi@meiji.com
authors: Satoshi
authors: S
authors: Takasugi
authors: Kinya
authors: K
authors: Ashida
authors: Suyaka
authors: S
authors: Maruyama
authors: Yukari
authors: Y
authors: Matsukiyo
authors: Tetsuo
authors: T
authors: Kaneko
authors: Taketo
authors: T
authors: Yamaji
mesh_terms: D000126:Achlorhydria / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D015519:Bone Density; D003611:Dairy Products; D005285:Fermentation; D007778:Lactobacillus / Q000378:metabolism*; D008297:Male; D009844:Oligosaccharides / Q000378:metabolism*; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D014057:Tomography, X-Ray Computed
chemical_list: D009844:Oligosaccharides; D054328:Proton Pump Inhibitors