title: Immunological Genome Project and systems immunology.
abstract: Immunological studies of single proteins in a single cell type have been complemented in recent years by larger studies, enabled by emerging high-throughput technologies. This trend has recently been exemplified by the discovery of gene networks controlling regulatory and effector αβ T cell subset development and human hematopoiesis. The Immunological Genome Project (ImmGen) aims to decipher the gene networks underpinning mouse hematopoiesis. The first phase, completed in 2012, profiled the transcriptome of 249 immune cell types. We discuss the utilities of the datasets in high-resolution mapping of the hematopoietic system. The immune transcriptome compendium has revealed unsuspected cell lineage relations and the network reconstruction has identified novel regulatory factors of hematopoiesis.
authors: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
authors: Tal
authors: T
authors: Shay
authors: Joonsoo
authors: J
authors: Kang
mesh_terms: D000818:Animals; D019070:Cell Lineage / Q000235:genetics / Q000276:immunology; D053263:Gene Regulatory Networks / Q000235:genetics* / Q000276:immunology*; D006410:Hematopoiesis / Q000235:genetics / Q000276:immunology; D006801:Humans; D015398:Signal Transduction / Q000235:genetics* / Q000276:immunology*; D059467:Transcriptome / Q000235:genetics* / Q000276:immunology*
keywords: hematopoiesis; systems immunology; transcriptional regulation
references: Nat Immunol. 2013 Jan;14(1):90-9
references: 23202270
references: Dev Cell. 2006 Nov;11(5):711-22
references: 17084362
references: Nat Immunol. 2010 Mar;11(3):197-206
references: 20139988
references: Cell. 2011 Oct 28;147(3):565-76
references: 22036565
references: Angew Chem Int Ed Engl. 2006 Mar 13;45(12):1844-54
references: 16470749
references: Dev Biol. 2005 Jul 1;283(1):29-39
references: 15913595
references: Nat Immunol. 2012 Oct;13(10):1000-9
references: 22902830
references: Nat Genet. 2009 May;41(5):553-62
references: 19377474
references: Nat Immunol. 2012 Apr 01;13(5):499-510
references: 22466668
references: Nat Immunol. 2012 Oct;13(10):991-9
references: 22961052
references: Cell. 2012 Oct 12;151(2):289-303
references: 23021777
references: Nat Genet. 2007 Apr;39(4):503-12
references: 17322878
references: J Immunol. 2011 Mar 1;186(5):3047-57
references: 21307297
references: Nat Rev Immunol. 2012 Oct;12(10):734-40
references: 22955842
references: Immunity. 2011 Nov 23;35(5):780-91
references: 22018469
references: Science. 2012 Mar 9;335(6073):1195-200
references: 22345399
references: Nat Immunol. 2013 Apr;14(4):404-12
references: 23396170
references: Dev Cell. 2002 Jul;3(1):137-47
references: 12110174
references: Proc Natl Acad Sci U S A. 2010 May 25;107(21):9777-82
references: 20457902
references: Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20060-5
references: 22109558
references: Nat Rev Immunol. 2008 Jan;8(1):9-21
references: 18097446
references: Blood. 2003 May 15;101(10):4115-21
references: 12531789
references: Nat Immunol. 2013 Jun;14(6):619-32
references: 23644507
references: Bioinformatics. 2007 Nov 1;23(21):2934-41
references: 17893089
references: Immunity. 2011 Dec 23;35(6):972-85
references: 22177921
references: Nat Immunol. 2012 Nov;13(11):1118-28
references: 23023392
references: Science. 2009 Oct 9;326(5950):257-63
references: 19729616
references: Cell. 2011 Jan 21;144(2):296-309
references: 21241896
references: Immunity. 2008 Dec 19;29(6):835-8
references: 19100694
references: Immunity. 2013 Apr 18;38(4):681-93
references: 23562159
references: Eur J Immunol. 2012 May;42(5):1272-81
references: 22539299
references: Nature. 2012 Sep 6;489(7414):57-74
references: 22955616
references: Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2946-51
references: 23382184
references: Science. 2012 Nov 16;338(6109):975-80
references: 22983707
references: Nat Immunol. 2012 Dec;13(12):1145-54
references: 23160217
references: Science. 2011 May 6;332(6030):687-96
references: 21551058
references: Immunity. 1999 Oct;11(4):433-42
references: 10549625
references: Nat Immunol. 2012 Sep;13(9):888-99
references: 22797772
references: Nat Immunol. 2012 Apr 01;13(5):511-8
references: 22473038
references: Immunity. 2001 Sep;15(3):419-34
references: 11567632
references: Nat Immunol. 2008 Oct;9(10):1091-4
references: 18800157
references: J Immunol. 2003 Sep 1;171(5):2413-20
references: 12928388
references: Immunity. 2012 Jul 27;37(1):48-59
references: 22770884
references: Nature. 2011 Aug 03;476(7358):63-8
references: 21814277
references: Nat Immunol. 2012 Oct;13(10):972-80
references: 22961053
references: Nat Immunol. 2013 Jun;14(6):633-43
references: 23624555