title: Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature.
abstract: Pleomorphic liposarcoma (PLPS) is a rare, high-grade sarcoma defined by the presence of pleomorphic lipoblasts. Constituting 5% of all liposarcomas, PLPS usually arises in deep soft tissues of the extremities, with rare occurrences in the dermis and subcutis. We describe a unique case of an 85-year-old Caucasian gentleman with a 1 year history of a pedunculated, pink, non-tender papule on the dorsum of his left arm, measuring 1.0 cm in maximum dimension. Biopsy revealed a dermal collection of atypical epithelioid and spindle cells superimposed on a sclerotic background, resembling a pleomorphic fibroma on low power. On high power, a central focus of discrete adipocytic differentiation with pleomorphic lipoblasts was present. Tumor cells were positive for S-100 and negative for desmin, actin, CD68, keratin, MART-1 and CD34. Clinicopathologic findings were consistent with PLPS and the diagnosis was made. PLPS is rarely localized to the dermis and one with low power features resembling a pleomorphic fibroma has not been previously described in the literature.
authors: Department of Pathology, Tufts Medical Center, Boston, MA, USA.
authors: Tariq
authors: T
authors: Al-Zaid
authors: Gretchen
authors: G
authors: Frieling
authors: Seth
authors: S
authors: Rosenthal
mesh_terms: D000369:Aged, 80 and over; D001706:Biopsy; D020405:Dermis / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005350:Fibroma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008080:Liposarcoma / Q000378:metabolism / Q000473:pathology; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D009363:Neoplasm Proteins
keywords: S100; atypical features; cutaneous neoplasm; soft tissue tumors