title: Hazardous alcohol consumption is associated with increased levels of B-type natriuretic peptide: evidence from two population-based studies.
abstract: Russia has very high mortality from cardiovascular disease (CVD), with evidence that heavy drinking may play a role. To throw further light on this association we have studied the association of alcohol with predictors of CVD risk including B-type natriuretic peptide (BNP). Levels of BNP increase primarily in response to abnormal cardiac chamber wall stretch which can occur both as a result of atherosclerosis as well as due to other types of damage to the myocardium. No previous population-based studies have investigated the association with alcohol. We analysed cross-sectional data on drinking behaviour in 993 men aged 25-60 years from the Izhevsk Family Study 2 (IFS2), conducted in the Russian city of Izhevsk in 2008-2009. Relative to non-drinkers, men who drank hazardously had an odds ratio (OR) of being in the top 20 % of the BNP distribution of 4.66 (95 % CI 2.13, 10.19) adjusted for age, obesity, waist-hip ratio, and smoking. Further adjustment for class of hypertension resulted in only slight attenuation of the effect, suggesting that this effect was not secondary to the influence of alcohol on blood pressure. In contrast hazardous drinking was associated with markedly raised ApoA1 and HDL cholesterol levels, but had little impact on levels of ApoB and LDL cholesterol. Similar but less pronounced associations were found in the Belfast (UK) component of the PRIME study conducted in 1991. These findings suggest that the association of heavy drinking with increased risk of cardiovascular disease may be partly due to alcohol-induced non-atherosclerotic damage to the myocardium.
authors: London School of Hygiene and Tropical Medicine, London, UK. david.leon@lshtm.ac.uk
authors: David A
authors: DA
authors: Leon
authors: Vladimir M
authors: VM
authors: Shkolnikov
authors: Svetlana
authors: S
authors: Borinskaya
authors: Juan-Pablo
authors: JP
authors: Casas
authors: Alun
authors: A
authors: Evans
authors: Artyom
authors: A
authors: Gil
authors: Frank
authors: F
authors: Kee
authors: Nikolay
authors: N
authors: Kiryanov
authors: Martin
authors: M
authors: McKee
authors: Mark G
authors: MG
authors: O'Doherty
authors: George B
authors: GB
authors: Ploubidis
authors: Olga
authors: O
authors: Polikina
authors: Maxim
authors: M
authors: Vassiliev
authors: Stefan
authors: S
authors: Blankenberg
authors: Hugh
authors: H
authors: Watkins
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects*; D016632:Apolipoprotein A-I / Q000097:blood* / Q000378:metabolism; D001055:Apolipoproteins B / Q000097:blood* / Q000378:metabolism; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood* / Q000378:metabolism; D011159:Population Surveillance; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D020097:Natriuretic Peptide, Brain
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