title: Effects of steroid administration and transcorneal electrical stimulation on the anatomic and electrophysiologic deterioration of nonarteritic ischemic optic neuropathy in a rodent model.
abstract: OBJECTIVE
  To elucidate the effectiveness of steroid administration and transcorneal electrical stimulation (TES) on anatomic changes and visual function in a rodent model of nonarteritic ischemic optic neuropathy (rNAION).
  
  
  METHODS
  Methylprednisolone (20 mg/kg) was injected through a central venous catheter twice a day for 3 days. TES was delivered with biphasic square pulses of 1 ms/phase, 100 μA of current, and 20 Hz of frequency for 60 min 3 h after induction on the 1st, 4th, 7th, 14th, and 28th days.
  
  
  RESULTS
  Intravenous infusion of methylprednisolone significantly decreased the degree of acute disc edema but did not preserve the inner retinal thinning, decreasing the amplitude of scotopic threshold responses (STR) and decreasing retinal ganglion cell (RGC) numbers in rNAION. TES preserved the decreasing STR amplitude and the decreasing RGC numbers in rNAION.
  
  
  CONCLUSIONS
  Steroids are effective for reducing disc edema in the acute stage in rNAION. TES is effective for preserving decreasing RGC numbers and function in the chronic stage of rNAION.
authors: Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, Miyazaki 889-1692, Japan.
authors: Takako
authors: T
authors: Osako
authors: Hideki
authors: H
authors: Chuman
authors: Tomoyuki
authors: T
authors: Maekubo
authors: Michitaka
authors: M
authors: Ishiai
authors: Naoko
authors: N
authors: Kawano
authors: Nobuhisa
authors: N
authors: Nao-I
mesh_terms: D000818:Animals; D003315:Cornea; D004558:Electric Stimulation / Q000379:methods*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008297:Male; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D051381:Rats; D012165:Retinal Ganglion Cells / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids
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