title: A new flavonoid C-glycoside from Solanum elaeagnifolium with hepatoprotective and curative activities against paracetamol-induced liver injury in mice.
abstract: A new flavonoid C-glycoside, kaempferol 8-C-beta-galactoside, along with twelve known glycosidic flavonoids was isolated from the aqueous methanolic extract of Solanum elaeagnifolium Cav. (Solanaceae), by conventional chromatographic methods; their structure elucidation was achieved using UV, ESI-MS, and NMR spectral analyses. Groups of six mice were administered S. elaeagnifolium extracts at 25, 50, and 75 mg/kg body weight (BW) prior to or post administration of a single dose of paracetamol (500 mg/kg BW). The extract showed significant hepatoprotective and curative effects against histopathological and histochemical damage induced by paracetamol in liver. The extract also ameliorated the elevation in glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), and alkaline phosphatase (ALP) levels. These findings were accompanied by a nearly normal architecture of the liver in the treated groups, compared to the paracetamol control group. As a positive control, silymarin was used, an established hepatoprotective drug against paracetamol-induced liver injury. This study provides the first validation of the hepatoprotective activity of S. elaeagnifolium.
authors: Marine Chemistry Department, Faculty of Marine Sciences, King Abdulaziz University, PO Box 80207, Jeddah 21589, Kingdom of Saudi Arabia. hawasusama@yahoo.com
authors: Usama W
authors: UW
authors: Hawas
authors: Ghadir M
authors: GM
authors: Soliman
authors: Lamia T
authors: LT
authors: Abou El-Kassem
authors: Abdel Razik H
authors: AR
authors: Farrag
authors: Khaled
authors: K
authors: Mahmoud
authors: Francisco
authors: F
authors: León
mesh_terms: D000082:Acetaminophen / Q000037:antagonists & inhibitors*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000201:enzymology / Q000517:prevention & control; D005419:Flavonoids / Q000302:isolation & purification* / Q000627:therapeutic use; D006027:Glycosides / Q000302:isolation & purification* / Q000627:therapeutic use; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D032322:Solanum / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D005419:Flavonoids; D006027:Glycosides; D000082:Acetaminophen