title: Laterality and the evolution of the prefronto-cerebellar system in anthropoids.
abstract: There is extensive evidence for an early vertebrate origin of lateralized motor behavior and of related asymmetries in underlying brain systems. We investigate human lateralized motor functioning in a broad comparative context of evolutionary neural reorganization. We quantify evolutionary trends in the fronto-cerebellar system (involved in motor learning) across 46 million years of divergent primate evolution by comparing rates of evolution of prefrontal cortex, frontal motor cortex, and posterior cerebellar hemispheres along individual branches of the primate tree of life. We provide a detailed evolutionary model of the neuroanatomical changes leading to modern human lateralized motor functioning, demonstrating an increased role for the fronto-cerebellar system in the apes dating to their evolutionary divergence from the monkeys (∼30 million years ago (Mya)), and a subsequent shift toward an increased role for prefrontal cortex over frontal motor cortex in the fronto-cerebellar system in the Homo-Pan ancestral lineage (∼10 Mya) and in the human ancestral lineage (∼6 Mya). We discuss these results in the context of cortico-cerebellar functions and their likely role in the evolution of human tool use and speech.
authors: Department of Anthropology, University College London, London, United Kingdom. j.smaers@ucl.ac.uk
authors: Jeroen B
authors: JB
authors: Smaers
authors: James
authors: J
authors: Steele
authors: Charleen R
authors: CR
authors: Case
authors: Katrin
authors: K
authors: Amunts
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002531:Cerebellum / Q000502:physiology*; D000882:Haplorhini / Q000145:classification / Q000502:physiology*; D006801:Humans; D010802:Phylogeny; D017397:Prefrontal Cortex / Q000502:physiology*; D013045:Species Specificity
references: Philos Trans R Soc Lond B Biol Sci. 1996 Oct 29;351(1346):1473-9
references: 8941959
references: Behav Brain Sci. 2005 Aug;28(4):575-89; discussion 589-633
references: 16209828
references: Philos Trans R Soc Lond B Biol Sci. 2012 Jan 12;367(1585):59-74
references: 22106427
references: J Comp Neurol. 1981 May 1;198(1):155-65
references: 7229138
references: Cereb Cortex. 2006 Jun;16(6):811-8
references: 16120793
references: Behav Brain Res. 1997 Dec;89(1-2):237-42
references: 9475631
references: Folia Primatol (Basel). 1981;35(1):1-29
references: 7014398
references: Neuropsychologia. 1998 Jul;36(7):625-41
references: 9723934
references: Brain Behav Evol. 2012;79(3):205-12
references: 22327843
references: Cereb Cortex. 2005 Jun;15(6):681-95
references: 15342430
references: Neural Netw. 1998 Oct;11(7-8):1317-29
references: 12662752
references: Neuroimage. 2005 Jan 15;24(2):332-8
references: 15627576
references: Evolution. 2009 Dec;63(12):3258-68
references: 19663993
references: Science. 1978 Oct 20;202(4365):324-7
references: 99817
references: Behav Processes. 1994 Dec;33(1-2):41-57
references: 24925239
references: Neuroscientist. 2006 Jun;12(3):211-31
references: 16684967
references: Neuroimage. 2007 Jul 1;36(3):943-54
references: 17468013
references: Neuropsychologia. 2007 Jun 11;45(10):2333-9
references: 17382360
references: Neuropsychologia. 1994 Feb;32(2):257-64
references: 8190249
references: Cortex. 2006 May;42(4):652-8
references: 16881273
references: Science. 1993 Apr 9;260(5105):216-9
references: 17807183
references: Neuroreport. 1998 Oct 5;9(14):3341-4
references: 9831474
references: J Neurophysiol. 1997 Mar;77(3):1313-24
references: 9084599
references: Neuropsychologia. 2000;38(3):304-12
references: 10678696
references: Brain Behav Evol. 2011;77(2):67-78
references: 21335939
references: Philos Trans R Soc Lond B Biol Sci. 2012 Jan 12;367(1585):37-47
references: 22106425
references: J Neurosci. 2003 Sep 10;23(23):8432-44
references: 12968006
references: Microsc Acta. 1982 Nov;86(4):339-46
references: 6759879
references: Neuropsychologia. 1995 Apr;33(4):407-19
references: 7617152
references: Neuroimage. 2009 May 15;46(1):39-46
references: 19457380
references: Neuroimage. 1996 Dec;4(3 Pt 1):216-22
references: 9345512
references: Neurosci Biobehav Rev. 1998 May;22(3):411-26
references: 9579329
references: Ann N Y Acad Sci. 2011 May;1225 Suppl 1:E94-104
references: 21599701
references: Neuroimage. 2009 Jan 15;44(2):489-501
references: 18835452
references: J Neurophysiol. 2011 Nov;106(5):2322-45
references: 21795627
references: Neuropsychologia. 2011 Jun;49(7):2004-12
references: 21447349
references: J Exp Zool. 1971 Jun;177(2):229-61
references: 5571594
references: Nat Rev Neurosci. 2006 Jul;7(7):511-22
references: 16791141
references: Ann N Y Acad Sci. 2002 Dec;978:273-88
references: 12582060
references: Neuroimage. 2010 Feb 1;49(3):2045-52
references: 19857577
references: Cereb Cortex. 2010 Mar;20(3):507-16
references: 19608779
references: J Physiol. 1969 Jun;202(2):437-70
references: 5784296
references: Behav Brain Res. 2010 Apr 2;208(2):436-43
references: 20035802
references: Nature. 1987 Jan 15-21;325(6101):249-51
references: 3808021
references: J Exp Psychol Hum Percept Perform. 2010 Aug;36(4):825-39
references: 20695702
references: J Cogn Neurosci. 2001 Oct 1;13(7):952-66
references: 11595098
references: Biol Lett. 2007 Apr 22;3(2):169-72
references: 17307721
references: Eur J Neurosci. 2011 Apr;33(7):1328-38
references: 21375598
references: Neuropsychologia. 1995 Dec;33(12):1637-46
references: 8745121
references: Ann N Y Acad Sci. 2011 Apr;1225:176-90
references: 21535004
references: Brain Res. 1977 May 27;127(2):279-82
references: 861760
references: PLoS One. 2010 Feb 09;5(2):e9123
references: 20161758
references: Cortex. 2010 Jul-Aug;46(7):821-30
references: 19926082
references: Neuropsychologia. 2003;41(3):252-62
references: 12457751
references: J Neurosci. 1992 Aug;12(8):2918-47
references: 1494940
references: Neuropsychologia. 2006;44(12):2582-6
references: 16730360
references: Bioinformatics. 2004 Jan 22;20(2):289-90
references: 14734327
references: Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18006-11
references: 23071335
references: J Neurophysiol. 2004 Jan;91(1):576-82
references: 12878717
references: Anim Cogn. 2009 Mar;12(2):217-35
references: 18810512
references: Neuroimage. 2001 Oct;14(4):853-61
references: 11554804
references: Cereb Cortex. 2009 Oct;19(10):2485-97
references: 19592571
references: Neuroimage. 2012 Mar;60(1):332-9
references: 22227053
references: Neuroimage. 2006 Aug 15;32(2):821-41
references: 16730195
references: Int Rev Neurobiol. 1997;41:61-82
references: 9378611
references: Curr Opin Neurobiol. 1992 Dec;2(6):802-6
references: 1477543
references: Neuroimage. 2012 Jul 2;61(3):533-41
references: 22504765