title: Transmission of Mycobacterium tuberculosis Beijing Strains, Alberta, Canada, 1991-2007.
abstract: Beijing strains are speculated to have a selective advantage over other Mycobacterium tuberculosis strains because of increased transmissibility and virulence. In Alberta, a province of Canada that receives a large number of immigrants, we conducted a population-based study to determine whether Beijing strains were associated with increased transmission leading to disease compared with non-Beijing strains. Beijing strains accounted for 258 (19%) of 1,379 pulmonary tuberculosis cases in 1991-2007; overall, 21% of Beijing cases and 37% of non-Beijing cases were associated with transmission clusters. Beijing index cases had significantly fewer secondary cases within 2 years than did non-Beijing cases, but this difference disappeared after adjustment for demographic characteristics, infectiousness, and M. tuberculosis lineage. In a province that has effective tuberculosis control, transmission of Beijing strains posed no more of a public health threat than did non-Beijing strains.
authors: Deanne
authors: D
authors: Langlois-Klassen
authors: Ambikaipakan
authors: A
authors: Senthilselvan
authors: Linda
authors: L
authors: Chui
authors: Dennis
authors: D
authors: Kunimoto
authors: L Duncan
authors: LD
authors: Saunders
authors: Dick
authors: D
authors: Menzies
authors: Richard
authors: R
authors: Long
mesh_terms: D000328:Adult; D000368:Aged; D002170:Canada / Q000453:epidemiology; D054242:Emigrants and Immigrants / Q000706:statistics & numerical data; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification* / Q000472:pathogenicity / Q000502:physiology; D012042:Registries; D012189:Retrospective Studies; D013183:Sputum / Q000382:microbiology; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission*
keywords: Canada; Mycobacterium tuberculosis and other mycobacteria; bacteria; disease transmission; emigrants and immigrants; epidemiology; infectious; tuberculosis
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