title: Mechanisms of aspirin desensitization.
abstract: Aspirin-exacerbated respiratory disease is a clinical syndrome characterized by severe, persistent asthma, hyperplastic eosinophilic sinusitis with nasal polyps, and reactions to aspirin and other nonsteroidal antiinflammatory drugs that preferentially inhibit cyclooxygenase 1. The mechanisms behind the therapeutic effects of aspirin desensitization remain poorly understood. Recent studies suggest that the clinical benefits may occur through direct inhibition of tyrosine kinases and the signal transducer and activator of transcription 6 signaling pathway, which results in inhibition of interleukin 4 production. In this article, the current understanding of the mechanisms of aspirin desensitization is reviewed and future areas of investigation are discussed.
authors: Department of Allergy and Immunology, National Jewish Medical and Research Center, University of Colorado, Denver, CO 80206, USA.
authors: Trever
authors: T
authors: Burnett
authors: Rohit
authors: R
authors: Katial
authors: Rafeul
authors: R
authors: Alam
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D016718:Arachidonic Acid / Q000378:metabolism; D001241:Aspirin / Q000009:adverse effects* / Q000494:pharmacology; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D015847:Interleukin-4 / Q000378:metabolism; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism; D018077:Receptors, Leukotriene / Q000235:genetics / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018077:Receptors, Leukotriene; D015847:Interleukin-4; D016718:Arachidonic Acid; C083169:leukotriene D4 receptor; D001241:Aspirin