title: Arthroplasty versus fusion in single-level cervical degenerative disc disease: a Cochrane review.
abstract: METHODS
  A systematic review of randomized controlled trials (RCTs).
  
  
  OBJECTIVE
  To assess the effects of arthroplasty versus fusion in the treatment of radiculopathy or myelopathy, or both, due to single-level cervical degenerative disc disease.
  
  
  BACKGROUND
  There is ongoing debate about whether fusion or arthroplasty is superior in the treatment of single-level cervical degenerative disc disease. Mainly because the intended advantage of arthroplasty compared with fusion, prevention of symptoms due to adjacent segment degeneration in the long term, is not confirmed yet. Until sufficient long-term results become available, it is important to know whether results of 1 of the 2 treatments are superior to the other in the first 1 to 2 years.
  
  
  METHODS
  We searched electronic databases for randomized controlled trials. We included randomized controlled trials that directly compared any type of cervical fusion with any type of cervical arthroplasty, with at least 1 year of follow-up. Study selection was performed independently by 3 review authors, and "risk of bias" assessment and data extraction were independently performed by 2 review authors. In case of missing data, we contacted the study authors or the study sponsor. We assessed the quality of evidence.
  
  
  RESULTS
  Nine studies (2400 participants) were included in this review; 5 of these studies had a low risk of bias. Results for the arthroplasty group were better than the fusion group for all primary comparisons, often statistically significant. For none of the primary outcomes was a clinically relevant difference in effect size shown. Quality of the evidence was low to moderate.
  
  
  CONCLUSIONS
  There is low to moderate quality evidence that results are consistently in favor of arthroplasty, often statistically significant. However, differences in effect size were invariably small and not clinically relevant for all primary outcomes.
  
  
  METHODS
  1.
authors: Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands. T.Boselie@MUMC.nl
authors: Toon F M
authors: TF
authors: Boselie
authors: Paul C
authors: PC
authors: Willems
authors: Henk
authors: H
authors: van Mameren
authors: Rob A
authors: RA
authors: de Bie
authors: Edward C
authors: EC
authors: Benzel
authors: Henk
authors: H
authors: van Santbrink
mesh_terms: D001178:Arthroplasty / Q000379:methods*; D002574:Cervical Vertebrae; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000601:surgery*; D017060:Patient Satisfaction; D016032:Randomized Controlled Trials as Topic; D013123:Spinal Fusion / Q000379:methods*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome