title: Impact of conization type on the resected cone volume: results of a retrospective multi-center study.
abstract: OBJECTIVE
  The extent of conization seems to influence the risk of preterm birth. The aim of this study was to compare the cone volume after surgical resection with large loop excision of the transformation zone (LLETZ) and cold knife conization (CKC).
  
  
  METHODS
  The present retrospective multi-center study comprises 804 consecutive women, who underwent LLETZ (n = 412) or CKC (n = 392) between 2004 and 2009. Univariate and multivariable analyses were performed to compare cone volumes removed by LLETZ and CKC and identify independent risk factors for large cone volume.
  
  
  RESULTS
  The median resected cone volume after LLETZ was significantly smaller [1.6 cm(3) (0.8-2.9)] than after CKC [2.1 cm(3) (1.4-3.5)] (<0.0001). Complete resection rates were comparable in both groups. Conization method, cone depth, and institution type were independent risk factors for removal of a large cone volume.
  
  
  CONCLUSIONS
  CKC removes larger cone volumes than LLETZ without the advantage of higher complete resection rates.
authors: Gynecologic Cancer Unit, Department of General Gynecology and Gynecologic Oncology, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria, christoph.grimm@meduniwien.ac.at.
authors: Christoph
authors: C
authors: Grimm
authors: Lindsay
authors: L
authors: Brammen
authors: Gerhard
authors: G
authors: Sliutz
authors: Monika
authors: M
authors: Weigert
authors: Paul
authors: P
authors: Sevelda
authors: Sophie
authors: S
authors: Pils
authors: Alexander
authors: A
authors: Reinthaller
authors: Stephan
authors: S
authors: Polterauer
mesh_terms: D000328:Adult; D000367:Age Factors; D002584:Cervix Uteri / Q000473:pathology / Q000601:surgery*; D019092:Conization / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D063728:Secondary Care Centers; D062606:Tertiary Care Centers; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*