title: A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite.
abstract: Evolutionary transitions between hermaphroditic and dioecious reproductive states are found in many groups of animals. To understand such transitions, it is important to characterize diverse modes of sex determination utilized by metazoans. Currently, little is known about how simultaneous hermaphrodites specify and maintain male and female organs in a single individual. Here we show that a sex-specific gene, Smed-dmd-1 encoding a predicted doublesex/male-abnormal-3 (DM) domain transcription factor, is required for specification of male germ cells in a simultaneous hermaphrodite, the planarian Schmidtea mediterranea. dmd-1 has a male-specific role in the maintenance and regeneration of the testes and male accessory reproductive organs. In addition, a homologue of dmd-1 exhibits male-specific expression in Schistosoma mansoni, a derived, dioecious flatworm. These results demonstrate conservation of the role of DM domain genes in sexual development in lophotrochozoans and suggest one means by which modulation of sex-specific pathways can drive the transition from hermaphroditism to dioecy.
authors: Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, 601 South Goodwin Avenue, Urbana, Illinois 61801, USA.
authors: Tracy
authors: T
authors: Chong
authors: James J
authors: JJ
authors: Collins
authors: John L
authors: JL
authors: Brubacher
authors: David
authors: D
authors: Zarkower
authors: Phillip A
authors: PA
authors: Newmark
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D012734:Disorders of Sex Development / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D017238:Genes, Helminth / Q000235:genetics; D005837:Genitalia, Male / Q000166:cytology / Q000378:metabolism; D005854:Germ Cells / Q000166:cytology / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D010932:Planarians / Q000166:cytology / Q000235:genetics / Q000378:metabolism*; D012038:Regeneration / Q000235:genetics; D012100:Reproduction, Asexual / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D012727:Sex Characteristics; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors
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