title: Dopamine modulates attentional control of auditory perception: DARPP-32 (PPP1R1B) genotype effects on behavior and cortical evoked potentials.
abstract: Using a specific variant of the dichotic listening paradigm, we studied the influence of dopamine on attentional modulation of auditory perception by assessing effects of allelic variation of a single-nucleotide polymorphism (SNP) rs907094 in the DARPP-32 gene (dopamine and adenosine 3', 5'-monophosphate-regulated phosphoprotein 32 kilodations; also known as PPP1R1B) on behavior and cortical evoked potentials. A frequent DARPP-32 haplotype that includes the A allele of this SNP is associated with higher mRNA expression of DARPP-32 protein isoforms, striatal dopamine receptor function, and frontal-striatal connectivity. As we hypothesized, behaviorally the A homozygotes were more flexible in selectively attending to auditory inputs than any G carriers. Moreover, this genotype also affected auditory evoked cortical potentials that reflect early sensory and late attentional processes. Specifically, analyses of event-related potentials (ERPs) revealed that amplitudes of an early component of sensory selection (N1) and a late component (N450) reflecting attentional deployment for conflict resolution were larger in A homozygotes than in any G carriers. Taken together, our data lend support for dopamine's role in modulating auditory attention both during the early sensory selection and late conflict resolution stages.
authors: Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, D-14195 Berlin, Germany. Shu-Chen.Li@tu-dresden.de
authors: Shu-Chen
authors: SC
authors: Li
authors: Susanne
authors: S
authors: Passow
authors: Wilfried
authors: W
authors: Nietfeld
authors: Julia
authors: J
authors: Schröder
authors: Lars
authors: L
authors: Bertram
authors: Hauke R
authors: HR
authors: Heekeren
authors: Ulman
authors: U
authors: Lindenberger
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001288:Attention / Q000502:physiology*; D001307:Auditory Perception / Q000235:genetics*; D001931:Brain Mapping; D002540:Cerebral Cortex; D004007:Dichotic Listening Tests; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32 / Q000235:genetics*; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011571:Psychoacoustics; D012333:RNA, Messenger / Q000378:metabolism; D011930:Reaction Time / Q000235:genetics; D011954:Receptors, Dopamine / Q000378:metabolism; D055815:Young Adult
chemical_list: D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D012333:RNA, Messenger; D011954:Receptors, Dopamine