title: Intravenous flurbiprofen axetil can stabilize the hemodynamic instability due to mesenteric traction syndrome--evaluation with continuous measurement of the systemic vascular resistance index using a FloTrac® sensor.
abstract: OBJECTIVE
  Evaluation of the stabilizing effect of intravenous flurbiprofen axetil against hemodynamic instability due to mesenteric traction syndrome (MTS) by continuous measurement of systemic vascular resistance index (SVRI) using a FloTrac(®) sensor was evaluated.
  
  
  METHODS
  Prospective randomized trial.
  
  
  METHODS
  A single-center study performed in an educational hospital.
  
  
  METHODS
  Two prospective studies were carried out, each with 40 patients scheduled for elective open abdominal surgery.
  
  
  METHODS
  Twenty patients received 50 mg of flurbiprofen axetil after the recognition of MTS by the anesthesiologist (group FT). The remaining patients served as controls (groups CP and CT).
  
  
  RESULTS
  SVRI data was collected every 20 seconds for 1 hour after starting the laparotomy. The average SVRI prior to skin incision was taken as the baseline. Following 3 values were devised to evaluate MTS: the S-value (sum total of changes in SVRI from baseline), the T-value (period during which SVRI remained 20% or more below baseline), and the M-value (maximum change in SVRI from baseline). In group FP, decrease in SVRI was smaller than in group CP, and statistical differences in the 3 values were found. In group FT, SVRI recovered earlier than in group CT, and statistical differences were found in S-value and T-value. However, the M-value had no statistical differences.
  
  
  CONCLUSIONS
  Intravenous flurbiprofen axetil can stabilize the hemodynamic instability due to MTS.
authors: Department of Anesthesia, Daiyukai General Hospital, Ichinomiya, Aichi, Japan. mtakada_md@yahoo.co.jp
authors: Motoshi
authors: M
authors: Takada
authors: Chieko
authors: C
authors: Taruishi
authors: Tomoko
authors: T
authors: Sudani
authors: Akira
authors: A
authors: Suzuki
authors: Hiroki
authors: H
authors: Iida
mesh_terms: D000005:Abdomen / Q000601:surgery; D000368:Aged; D000768:Anesthesia, General; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D002302:Cardiac Output / Q000502:physiology; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005483:Flushing / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007022:Hypotension / Q000188:drug therapy*; D007262:Infusions, Intravenous; D007431:Intraoperative Complications / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D007813:Laparotomy; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D011446:Prospective Studies; D013577:Syndrome; D013610:Tachycardia / Q000188:drug therapy*; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005480:Flurbiprofen; C504422:flurbiprofen axetil
keywords: cardiac output; flurbiprofen axetil; mesenteric traction syndrome; preventive effect; systemic vascular resistance index; therapeutic effect