title: Pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: clinical strategies.
abstract: Attention deficit hyperactivity disorder (ADHD) is a common neurobehavioral disorder of childhood that can result in significant functional impairment, and if not adequately treated can lead to impaired quality of life. Pharmacotherapy is considered the first-line treatment for ADHD in children and adolescents. We review both recent literature and seminal studies regarding the pharmacological treatment of ADHD in children and adolescents. There is ample evidence for the efficacy and safety of both stimulants and non-stimulants in the treatment of ADHD. We review important aspects of evaluation and assessment and discuss first-line pharmacological treatments and as well as when to consider using alternative pharmacological agents. Treatment approaches to manage frequently seen comorbid disorders with ADHD are also covered.
authors: Anna C
authors: AC
authors: Shier
authors: Thomas
authors: T
authors: Reichenbacher
authors: Harinder S
authors: HS
authors: Ghuman
authors: Jaswinder K
authors: JK
authors: Ghuman
keywords: ADHD; adolescents; children; clinical strategies; non-stimulants; stimulants
references: Clin Pediatr (Phila). 2000 Jan;39(1):15-25
references: 10660814
references: J Child Adolesc Psychopharmacol. 2008 Oct;18(5):413-47
references: 18844482
references: Biol Psychiatry. 2005 Jun 1;57(11):1313-23
references: 15950004
references: Neurology. 2002 Feb 26;58(4):527-36
references: 11865128
references: Neurosci Biobehav Rev. 2012 Apr;36(4):1093-106
references: 22305957
references: J Child Psychol Psychiatry. 2001 May;42(4):493-502
references: 11383965
references: J Child Adolesc Psychopharmacol. 2006 Oct;16(5):589-98
references: 17069547
references: Bipolar Disord. 2005 Dec;7(6):497-506
references: 16403175
references: J Child Adolesc Psychopharmacol. 2005 Oct;15(5):777-86
references: 16262594
references: Pediatrics. 1999 Aug;104(2):e20
references: 10429138
references: Am J Psychiatry. 2010 Apr;167(4):409-17
references: 20080984
references: Curr Med Res Opin. 2011;27 Suppl 2:13-22
references: 21973228
references: P T. 2009 Dec;34(12):678-94
references: 20140141
references: Am J Psychiatry. 2011 Nov;168(11):1154-63
references: 21865529
references: Child Adolesc Psychiatry Ment Health. 2011 May 11;5:14
references: 21569378
references: Am J Psychiatry. 2001 Jul;158(7):1067-74
references: 11431228
references: J Child Adolesc Psychopharmacol. 2011 Feb;21(1):21-32
references: 21288121
references: J Am Acad Child Adolesc Psychiatry. 2009 Feb;48(2):155-65
references: 19106767
references: J Pediatr. 2008 Mar;152(3):394-9
references: 18280848
references: J Child Adolesc Psychopharmacol. 2009 Oct;19(5):485-92
references: 19877972
references: J Child Adolesc Psychopharmacol. 2012 Jun;22(3):206-14
references: 22612526
references: J Am Acad Child Adolesc Psychiatry. 2011 Jan;50(1):9-21
references: 21156266
references: J Am Acad Child Adolesc Psychiatry. 1997 Apr;36(4):539-44
references: 9100429
references: Arch Intern Med. 1990 Sep;150(9):1881-4
references: 2102668
references: N Engl J Med. 2006 Apr 6;354(14):1445-8
references: 16549404
references: J Child Adolesc Psychopharmacol. 2009 Apr;19(2):155-66
references: 19364293
references: J Clin Psychiatry. 2005 Mar;66(3):294-9
references: 15766294
references: Neuropsychiatr Dis Treat. 2008 Jun;4(3):499-506
references: 18830439
references: J Child Adolesc Psychopharmacol. 2007 Oct;17(5):689-700
references: 17979588
references: Pediatrics. 2009 May;123(5):1273-9
references: 19403491
references: Psychol Med. 2007 Dec;37(12):1743-52
references: 17349106
references: J Am Acad Child Adolesc Psychiatry. 2001 May;40(5):516-24
references: 11349695
references: J Am Acad Child Adolesc Psychiatry. 2007 Aug;46(8):1015-1027
references: 17667480
references: J Child Adolesc Psychopharmacol. 2009 Oct;19(5):501-10
references: 19877974
references: Acta Psychiatr Scand. 2012 Feb;125(2):114-26
references: 22118249
references: J Am Acad Child Adolesc Psychiatry. 2009 May;48(5):484-500
references: 19318991
references: J Psychopharmacol. 2012 Jun;26(6):771-7
references: 22219219
references: CNS Drugs. 2010 Sep;24(9):755-68
references: 20806988
references: J Clin Psychopharmacol. 2004 Feb;24(1):30-5
references: 14709944
references: J Am Acad Child Adolesc Psychiatry. 1999 Dec;38(12):1551-9
references: 10596256
references: Am J Psychiatry. 2009 Jan;166(1):58-63
references: 18794206
references: Semin Pediatr Neurol. 2005 Dec;12(4):217-21
references: 16780292
references: J Am Acad Child Adolesc Psychiatry. 2006 Jun;45(6):642-657
references: 16721314
references: Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19649-54
references: 18024590
references: Arch Pediatr Adolesc Med. 2008 Oct;162(10):916-21
references: 18838643
references: Pediatrics. 2011 Apr;127(4):e862-8
references: 21422081
references: J Am Acad Child Adolesc Psychiatry. 2005 Apr;44(4):349-57
references: 15782082
references: Ann Pharmacother. 2009 Jun;43(6):1084-95
references: 19470858
references: J Am Acad Child Adolesc Psychiatry. 2005 Mar;44(3):240-8
references: 15725968
references: J Pediatr. 2010 Oct;157(4):635-40, 640.e1
references: 20605163
references: J Am Acad Child Psychiatry. 1985 Sep;24(5):617-29
references: 3900182
references: Case Rep Med. 2011;2011:952584
references: 21765848
references: Brain Res Cogn Brain Res. 2001 Aug;12(1):145-52
references: 11489617
references: J Am Acad Child Adolesc Psychiatry. 2009 Dec;48(12):1143-54
references: 19858761
references: Pediatr Clin North Am. 2011 Feb;58(1):99-120, xi
references: 21281851
references: Psychiatry Res. 1991 Feb;36(2):141-55
references: 2017529
references: Curr Psychiatry Rep. 2008 Oct;10(5):412-8
references: 18803915
references: J Child Adolesc Psychopharmacol. 2009 Jun;19(3):215-26
references: 19519256
references: Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):145-9
references: 17765380
references: BMC Psychiatry. 2011 Nov 10;11:176
references: 22074258
references: Am J Psychiatry. 2006 Jul;163(7):1149-52
references: 16816217
references: Int J Neuropsychopharmacol. 2012 Feb;15(1):15-26
references: 22017969
references: J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):188-96
references: 11211367
references: J Am Acad Child Adolesc Psychiatry. 2008 Feb;47(2):180-188
references: 18182963
references: Neurology. 2005 Dec 27;65(12):1941-9
references: 16380617
references: Arch Gen Psychiatry. 1999 Dec;56(12):1073-86
references: 10591283
references: J Am Acad Child Adolesc Psychiatry. 2005 May;44(5):418-27
references: 15843763
references: Psychiatry Res. 2009 Aug 15;168(3):234-7
references: 19439364
references: J Am Acad Child Adolesc Psychiatry. 2001 Mar;40(3):307-14
references: 11288772
references: J Am Acad Child Adolesc Psychiatry. 2008 Sep;47(9):994-1009
references: 18580502
references: J Am Acad Child Adolesc Psychiatry. 2012 Jul;51(7):733-41
references: 22721596
references: J Pediatr Psychol. 2003 Dec;28(8):559-67
references: 14602846
references: Biol Psychiatry. 2011 Aug 1;70(3):255-62
references: 21664605
references: Arch Dis Child. 2005 Aug;90(8):801-6
references: 16040876
references: J Am Acad Child Adolesc Psychiatry. 2004 May;43(5):559-67
references: 15100562
references: Prim Care Companion J Clin Psychiatry. 2006;8(6):352-60
references: 17245457
references: Pediatrics. 2008 Jan;121(1):e73-84
references: 18166547
references: J Am Acad Child Adolesc Psychiatry. 2009 Sep;48(9):884-893
references: 19625978
references: Pediatrics. 2003 Jan;111(1):179-85
references: 12509574
references: Am J Psychiatry. 2005 Jan;162(1):58-64
references: 15625202
references: Neurology. 2006 Sep 26;67(6):1023-7
references: 17000972
references: Evid Based Ment Health. 2012 Aug;15(3):74
references: 22581018
references: J Dev Behav Pediatr. 2006 Feb;27(1):1-10
references: 16511362
references: J Am Acad Child Adolesc Psychiatry. 1999 May;38(5):614-9; discussion 619-22
references: 10230195
references: J Clin Psychiatry. 1998;59 Suppl 7:50-8
references: 9680053
references: Biol Psychiatry. 2012 Mar 1;71(5):458-66
references: 22209640
references: Am J Psychiatry. 2012 Feb;169(2):160-6
references: 22420039
references: J Am Acad Child Adolesc Psychiatry. 2007 Jul;46(7):894-921
references: 17581453
references: J Am Acad Child Adolesc Psychiatry. 1991 Mar;30(2):233-40
references: 2016227
references: J Atten Disord. 2010 Sep;14(2):109-20
references: 20495160
references: Clin Pediatr (Phila). 2009 Sep;48(7):723-33
references: 19420182
references: J Am Acad Child Adolesc Psychiatry. 2006 Nov;45(11):1284-1293
references: 17023867
references: Brain Res Cogn Brain Res. 2001 Oct;12(2):315-20
references: 11587900
references: Annu Rev Med. 2002;53:113-31
references: 11818466
references: Curr Protoc Neurosci. 2011 Jan;Chapter 9:Unit9.35
references: 21207367
references: Biol Psychiatry. 2009 Apr 1;65(7):571-7
references: 19103438
references: Expert Rev Pharmacoecon Outcomes Res. 2006 Aug;6(4):379-90
references: 20528508
references: J Atten Disord. 2014 Aug;18(6):511-20
references: 22653807
references: J Child Adolesc Psychopharmacol. 2005 Apr;15(2):191-202
references: 15910204
references: Lancet. 2005 Jul 16-22;366(9481):237-48
references: 16023516
references: J Atten Disord. 2008 Jan;11(4):470-81
references: 17934184
references: Pharmacotherapy. 2009 Jun;29(6):656-79
references: 19476419
references: Pediatrics. 2003 Jan;111(1):97-109
references: 12509561
references: CNS Drugs. 2009;23 Suppl 1:21-31
references: 19621975
references: Annu Rev Neurosci. 2009;32:209-24
references: 19400723
references: Pharmacol Biochem Behav. 2006 Mar;83(3):380-90
references: 16580713
references: J Pediatr Psychol. 2007 Nov-Dec;32(10):1203-13
references: 17602186
references: J Child Adolesc Psychopharmacol. 2010 Feb;20(1):49-54
references: 20166796
references: J Child Psychol Psychiatry. 2006 Oct;47(10):1051-62
references: 17073984
references: J Am Acad Child Adolesc Psychiatry. 2004 Sep;43(9):1068-9
references: 15322408
references: Pediatrics. 2005 Dec;116(6):e777-84
references: 16322134
references: J Am Acad Child Adolesc Psychiatry. 2011 Feb;50(2):171-9
references: 21241954
references: Pediatrics. 2002 Dec;110(6):e75
references: 12456942
references: Atten Defic Hyperact Disord. 2010 Mar;2(1):1-20
references: 21432586
references: Pediatrics. 2011 Jun;127(6):e1406-13
references: 21555501
references: J Am Acad Child Adolesc Psychiatry. 2007 Sep;46(9):1119-1127
references: 17712235
references: Paediatr Drugs. 2013 Feb;15(1):1-8
references: 23329386
references: J Am Acad Child Adolesc Psychiatry. 1999 Nov;38(11):1442-54
references: 10560232
references: J Child Adolesc Psychopharmacol. 2009 Oct;19(5):493-9
references: 19877973
references: J Am Acad Child Adolesc Psychiatry. 1996 Oct;35(10):1314-21
references: 8885585
references: Psychopharmacol Bull. 1998;34(1):55-60
references: 9564199
references: J Atten Disord. 2002 Jan;5(3):143-54
references: 11911007
references: Drug Saf. 2008;31(4):345-54
references: 18366245
references: J Am Acad Child Adolesc Psychiatry. 2003 Aug;42(8):886-94
references: 12874489
references: Am J Psychiatry. 2008 May;165(5):597-603
references: 18316421
references: BMC Psychiatry. 2005 Jul 26;5:29
references: 16042816
references: J Am Acad Child Adolesc Psychiatry. 2007 Sep;46(9):1128-1137
references: 17712236
references: Pediatrics. 2004 Apr;113(4 Suppl):1133-40
references: 15060210
references: Arch Gen Psychiatry. 1999 Dec;56(12):1088-96
references: 10591284
references: J Child Adolesc Psychopharmacol. 2011 Oct;21(5):495-8
references: 22040197
references: J Am Acad Child Adolesc Psychiatry. 2009 Feb;48(2):176-85
references: 20040824
references: J Child Adolesc Psychopharmacol. 2007 Oct;17(5):563-80
references: 17979578
references: Am J Psychiatry. 2008 May;165(5):604-9
references: 18381904
references: J Child Adolesc Psychopharmacol. 2009 Aug;19(4):329-39
references: 19702485
references: J Consult Clin Psychol. 2003 Jun;71(3):540-52
references: 12795577
references: J Am Acad Child Adolesc Psychiatry. 2007 May;46(5):566-572
references: 17450047