title: Cutaneous presentation of chronic lymphocytic leukemia as unique extramedullar involvement in a patient with normal peripheral blood lymphocyte count (monoclonal B-cell lymphocytosis).
abstract: Skin infiltration by chronic lymphocytic leukemia (CLL) is very rare and almost all reported cases occur in advanced stage. We report a patient with no relevant past medical history who presented with cutaneous erythematous plaques. A punch biopsy showed typical CLL morphologic and immunophenotypic features. Subsequent studies revealed a normal lymphocyte count in peripheral blood, and there was no evidence of lymphadenopathy or organomegaly. Flow cytometry demonstrated a clonal B-cell population both in the bone marrow and peripheral blood (1.60 × 10(9)/l) with a CLL phenotype, but it did not fulfill required criteria for CLL diagnosis. Without cutaneous involvement, this case should be classified as monoclonal B-cell lymphocytosis.
authors: Department of Pathology, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain. gustavotapiam@hotmail.com
authors: Gustavo
authors: G
authors: Tapia
authors: José-Luis
authors: JL
authors: Mate
authors: María-José
authors: MJ
authors: Fuente
authors: José-Tomás
authors: JT
authors: Navarro
authors: Maria-Teresa
authors: MT
authors: Fernández-Figueras
authors: Jordi
authors: J
authors: Juncà
authors: Carlos
authors: C
authors: Ferrándiz
authors: Aurelio
authors: A
authors: Ariza
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000473:pathology; D018655:Lymphocyte Count; D008218:Lymphocytosis / Q000097:blood / Q000473:pathology; D008297:Male; D012878:Skin Neoplasms / Q000097:blood / Q000473:pathology
keywords: cutaneous lymphoma; hematopathology; molecular pathology