title: Comparison of the efficacy and tolerability of ivabradine and ranolazine in patients of chronic stable angina pectoris.
abstract: BACKGROUND
  To compare the efficacy and tolerability of Ivabradine (IVA) and Ranolazine (RAN) in chronic angina patients.
  
  
  METHODS
  This was a follow-on, open-label trial conducted in a tertiary care hospital of Uttarakhand. Thirty patients each taking IVA 5 mg twice daily or RAN 500 mg twice daily were distributed to the respective groups. Patients were asked to fill a pretested questionnaire on frequency of anginal attacks and adverse reactions before and 2, 4 and 8 weeks after taking the respective medicines. Their blood pressure, heart rate and routine hematological and biochemical estimations were performed at baseline and after intervention. Results were statistically analyzed using different statistical tests, with P < 0.05 considered as significant.
  
  
  RESULTS
  There was no significant difference in the frequency of anginal attacks per week between the groups. The adverse drug reactions (ADRs) reported in the IVA group were dizziness (30%), headache (16.6%), backache (16.6%), vertigo (13.3%), blurred vision (13.3%), muscle cramps (10%), arthralgia (10%), cough and dyspnea (6.6%), hypersensitivity rash (6.6%), fever (3.3%) and nausea (3.3%). The ADRs in the RAN group were nausea (26.6%), dizziness (23.3%), vomiting (3.3%), constipation (3.3%) and vertigo (3.3%). The blood pressure, heart rate and routine hematological and biochemical evaluations did not show any significant difference in the pre-post values. IVA significantly decreased the resting heart rate after eight weeks of intervention.
  
  
  CONCLUSIONS
  Both antianginal agents appeared equiactive. However, RAN had a better safety and tolerability profile than IVA. Serum sickness-like reaction was an adverse event noticed with IVA, which needs causality establishment.
authors: Department of Pharmacology, Veer Chandra Singh Garhwali Government Medical Sciences and Research Institute, Srikot, Uttarakhand, India.
authors: Aditi
authors: A
authors: Chaturvedi
authors: Yogendra
authors: Y
authors: Singh
authors: Harish
authors: H
authors: Chaturvedi
authors: Vijay
authors: V
authors: Thawani
authors: Sakshi
authors: S
authors: Singla
authors: Deepak
authors: D
authors: Parihar
keywords: Antianginals; dizziness; equiefficacious; nausea; serum sickness-like reaction
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