title: [Diet-induced obesity and GPR120].
abstract: Free fatty acids (FFAs) have been demonstrated to act as ligands of several G-protein-coupled receptors (GPCRs). GPR120 is activated by unsaturated long-chain FFAs and has a crucial role in various physiological homeostasis mechanisms such as incretin hormone secretion and adipogenesis. Recent studies showed that a lipid sensor GPR120 has a key role in sensing dietary fat and in the control of energy homeostasis in both humans and rodents. Dysfunction of GPR120 is identified as a novel risk factor for diet-induced obesity. In this review, I provides recent development in the field and discusses its physiological roles and potential as drug targets.
authors: Division of Molecular Medicine and Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine.
authors: Atsuhiko
authors: A
authors: Ichimura
mesh_terms: D050156:Adipogenesis; D000818:Animals; D004032:Diet / Q000009:adverse effects*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006801:Humans; D009765:Obesity / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism
chemical_list: D005230:Fatty Acids, Nonesterified; D043562:Receptors, G-Protein-Coupled