title: Analysis of high-altitude de-acclimatization syndrome after exposure to high altitudes: a cluster-randomized controlled trial.
abstract: The syndrome of high-altitude de-acclimatization commonly takes place after long-term exposure to high altitudes upon return to low altitudes. The syndrome severely affects the returnee's quality of life. However, little attention has been paid to careful characterization of the syndrome and their underlying mechanisms. Male subjects from Chongqing (n = 67, 180 m) and Kunming (n = 70, 1800 m) visited a high-altitude area (3650 m) about 6 months and then returned to low-altitude. After they came back, all subjects were evaluated for high-altitude de-acclimatization syndrome on the 3(rd), 50(th), and 100(th). Symptom scores, routine blood and blood gas tests, and myocardial zymograms assay were used for observation their syndrome. The results showed that the incidence and severity of symptoms had decreased markedly on the 50(th) and 100(th) days, compared with the 3(rd) day. The symptom scores and incidence of different symptoms were lower among subjects returning to Kunming than among those returning to Chongqing. On the 3(rd) day, RBC, Hb, Hct, CK, CK-MB, and LDH values were significantly lower than values recorded at high altitudes, but they were higher than baseline values. On the 50(th) day, these values were not different from baseline values, but LDH levels did not return to baseline until the 100(th) day. These data show that, subjects who suffered high-altitude de-acclimatization syndrome, the recovery fully processes takes a long time (≥ 100(th) days). The appearance of the syndrome is found to be related to the changes in RBC, Hb, Hct, CK, CK-MB, and LDH levels, which should be caused by reoxygenation after hypoxia.
authors: Institute of Respiratory Diseases, The Second Affiliated Hospital of the Third Military Medical University, Chongqing, China.
authors: Binfeng
authors: B
authors: He
authors: Jianchun
authors: J
authors: Wang
authors: Guisheng
authors: G
authors: Qian
authors: Mingdong
authors: M
authors: Hu
authors: Xinming
authors: X
authors: Qu
authors: Zhenghua
authors: Z
authors: Wei
authors: Jin
authors: J
authors: Li
authors: Yan
authors: Y
authors: Chen
authors: Huaping
authors: H
authors: Chen
authors: Qiquan
authors: Q
authors: Zhou
authors: Guansong
authors: G
authors: Wang
mesh_terms: D000064:Acclimatization; D000136:Acid-Base Equilibrium; D000293:Adolescent; D000328:Adult; D000531:Altitude; D002245:Carbon Dioxide / Q000097:blood; D016022:Case-Control Studies; D016000:Cluster Analysis; D052279:Creatine Kinase, MB Form / Q000097:blood; D004912:Erythrocytes / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D010100:Oxygen / Q000097:blood; D013577:Syndrome; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D002245:Carbon Dioxide; D007770:L-Lactate Dehydrogenase; D052279:Creatine Kinase, MB Form; D010100:Oxygen
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