title: IL2/IL21 region polymorphism influences response to rituximab in systemic lupus erythematosus patients.
abstract: To determine whether the IL2/IL21 region, a general autoimmunity locus, contributes to the observed variation in response to rituximab in patients with systemic lupus erythematosus as well as to analyze its influence in a cohort including other autoimmune diseases. rs6822844 G/T polymorphism at the IL2-IL21 region was analyzed by TaqMan assay in 84 systemic lupus erythematosus (SLE) and 60 different systemic autoimmune diseases Spanish patients receiving rituximab. Six months after the first infusion patients were classified, according to the EULAR criteria, as good responders, partial responders and non-responders. A statistically significant difference was observed in GG genotype frequency between responder (total and partial response) (83.56%) and non-responder (45.45%) SLE patients (p=0.010, odds ratio (OR)=6.10 [1.28-29.06]). No association with the response was evident in the group of patients with autoimmune diseases other than lupus. Furthermore, when both groups of patients were pooled in a meta-analysis, a reduced statistical significance of the association was observed (p=0.024, OR=3.53 [1.06-11.64]). Our results show for a first time that IL2-IL21 region seems to play a role in the response to rituximab in SLE patients but not in other autoimmune diseases.
authors: Instituto de Parasitología y Biomedicina López-Neyra (IPBLN), CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s/n, 18100, Armilla, Granada, Spain. anamaort@ipb.csic.es
authors: Ana
authors: A
authors: Márquez
authors: Cristina Lucía
authors: CL
authors: Dávila-Fajardo
authors: Gema
authors: G
authors: Robledo
authors: José Luis Callejas
authors: JL
authors: Rubio
authors: Enrique
authors: E
authors: de Ramón Garrido
authors: Francisco J
authors: FJ
authors: García-Hernández
authors: Rocío
authors: R
authors: González-León
authors: Raquel
authors: R
authors: Ríos-Fernández
authors: José Cabeza
authors: JC
authors: Barrera
authors: Ma Francisca
authors: MF
authors: González-Escribano
authors: Ma Teresa Camps
authors: MT
authors: García
authors: Ma Jesús Castillo
authors: MJ
authors: Palma
authors: Ma
authors: M
authors: del Mar Ayala
authors: Norberto
authors: N
authors: Ortego-Centeno
authors: Javier
authors: J
authors: Martín
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000494:pharmacology* / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D005838:Genotype; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics*; D007378:Interleukins / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D016017:Odds Ratio; D010597:Pharmacogenetics / Q000379:methods*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D000069283:Rituximab; D013030:Spain; D000098546:Interleukin-21
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; C508594:IL2 protein, human; D007376:Interleukin-2; D007378:Interleukins; D000069283:Rituximab; D000098546:Interleukin-21
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