title: Sesquiterpenoids from the herb of Leonurus japonicus.
abstract: Two new sesquiterpenoids, (-)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (-)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3-8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP.
authors: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China.
authors: Liang
authors: L
authors: Xiong
authors: Qin-Mei
authors: QM
authors: Zhou
authors: Cheng
authors: C
authors: Peng
authors: Xiao-Fang
authors: XF
authors: Xie
authors: Li
authors: L
authors: Guo
authors: Xiao-Hong
authors: XH
authors: Li
authors: Juan
authors: J
authors: Liu
authors: Zhao-Hua
authors: ZH
authors: Liu
authors: Ou
authors: O
authors: Dai
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000254:growth & development*; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D031332:Leonurus / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes; D000244:Adenosine Diphosphate
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