title: The impact of age on outcomes in chronic obstructive pulmonary disease differs by relationship status.
abstract: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that can lead to early-onset chronic obstructive pulmonary disease (COPD). The objective of this study was to examine the impact of age on psychological and clinical outcomes among individuals with AATD-associated COPD. 468 individuals with AATD-associated COPD (age 32-84 at baseline) completed questionnaires at baseline, 1- and 2-year follow-up. Age was examined as a predictor of depression, anxiety, health-related quality of life, and breathlessness at all three time points using linear mixed models. Age was associated with anxiety (b = -0.09, SE = 0.02, p < 0.001) and health-related quality of life (b = -0.29, SE = 0.09, p < 0.001). Age also had a statistically significant interaction with relationship status when predicting depression, health-related quality of life, and breathlessness. Among individuals who were single, younger age was associated with more symptoms of depression (b = -0.08, SE = 0.03, p < 0.01), worse health-related quality of life (b = -0.61, SE = 0.16, p < 0.001), and more breathlessness (b = -0.023, SE = 0.009, p < 0.01) throughout the 2-year study. Age was not associated with these three outcomes among individuals who were married/part of an unmarried couple. Results suggest that individuals who develop a chronic illness at a young age, particularly those who are single, may be more likely to have worse psychological and clinical outcomes.
authors: Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206, USA, holmk@njhealth.org.
authors: Kristen E
authors: KE
authors: Holm
authors: Melissa R
authors: MR
authors: Plaufcan
authors: Dee W
authors: DW
authors: Ford
authors: Robert A
authors: RA
authors: Sandhaus
authors: Matthew
authors: M
authors: Strand
authors: Charlie
authors: C
authors: Strange
authors: Frederick S
authors: FS
authors: Wamboldt
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology* / Q000523:psychology*; D001007:Anxiety / Q000150:complications / Q000175:diagnosis; D003863:Depression / Q000150:complications / Q000175:diagnosis; D004417:Dyspnea / Q000150:complications; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000235:genetics / Q000523:psychology* / Q000628:therapy*; D011788:Quality of Life / Q000523:psychology; D012042:Registries; D012847:Single Person / Q000523:psychology*; D018454:Spouses / Q000523:psychology*; D016896:Treatment Outcome; D019896:alpha 1-Antitrypsin Deficiency / Q000150:complications / Q000235:genetics / Q000523:psychology*
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