title: Alpha-7 nicotinic acetylcholine receptor agonists in intracerebral hemorrhage: an evaluation of the current evidence for a novel therapeutic agent.
abstract: Intracerebral hemorrhage (ICH) is the most deadly and least treatable subtype of stroke, and at the present time there are no evidence-based therapeutic interventions for patients with this disease. Secondary injury mechanisms are known to cause substantial rates of morbidity and mortality following ICH, and the inflammatory cascade is a major contributor to this post-ICH secondary injury. The alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonists have a well-established antiinflammatory effect and have been shown to attenuate perihematomal edema volume and to improve functional outcome in experimental ICH. The authors evaluate the current evidence for the use of an α7-nAChR agonist as a novel therapeutic agent in patients with ICH.
authors: Department of Neurological Surgery, Columbia University, New York, New York, USA.
authors: Eric S
authors: ES
authors: Sussman
authors: Christopher P
authors: CP
authors: Kellner
authors: Michael M
authors: MM
authors: McDowell
authors: Samuel S
authors: SS
authors: Bruce
authors: Simon G
authors: SG
authors: Heuts
authors: Zong
authors: Z
authors: Zhuang
authors: Rachel A
authors: RA
authors: Bruce
authors: Jan
authors: J
authors: Claassen
authors: E Sander
authors: ES
authors: Connolly
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000150:complications / Q000188:drug therapy*; D004660:Encephalitis / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D018722:Nicotinic Agonists / Q000627:therapeutic use*; D064569:alpha7 Nicotinic Acetylcholine Receptor / Q000819:agonists* / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D018722:Nicotinic Agonists; D064569:alpha7 Nicotinic Acetylcholine Receptor