title: Pleiotropic antioxidant potential of rosuvastatin in preventing cardiovascular disorders.
abstract: Rosuvastatin is a promising synthetic hydrophillic statin which provides potential benefits in reducing cardiovascular risk factors. Rosuvastatin has potent ability to diminish low density lipoprotein, very low density lipoprotein, triglycerides and enhance high density lipoprotein level to manage high cholesterol level and associated cardiovascular diseases. Intriguingly, numerous studies demonstrated that rosuvastatin can reverse the cardiac disorders such as hypertension, atherosclerosis, ischemic heart disease, congestive heart failure and cardiomyopathy by reducing reactive oxygen species mediated oxidative stress. Rosuvastatin maintain the balance between oxidant generation and oxidant scavenging by reducing NADPH (nicotinamide adenine dinucleotide phosphate)-dependent production of reactive oxygen species, suppressing endothelial nitric oxide synthase (eNOS) uncoupling, inducing and upregulating antioxidant defense mechanism. This review, summaries pleiotropic antioxidant evidences of rosuvastatin in favor of cardioprotection.
authors: Cardiovascular Pharmacology Division, Department of Pharmacology, Institute of Pharmacy, Rajendra Institute of Technology and Sciences (RITS), Sirsa 125055, India.
authors: Rajkiran
authors: R
authors: Mahalwar
authors: Deepa
authors: D
authors: Khanna
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000201:enzymology / Q000378:metabolism / Q000517:prevention & control*; D005464:Fluorobenzenes / Q000494:pharmacology*; D006801:Humans; D019255:NADPH Oxidases / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D011743:Pyrimidines / Q000494:pharmacology*; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D005464:Fluorobenzenes; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium; D052250:Nitric Oxide Synthase Type III; D019255:NADPH Oxidases