title: Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model.
abstract: OBJECTIVE
  To observe the combination effect of doxorubicin and Citrus hystrix (kaffir lime's) peel ethanolic extract (ChEE) on blood serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity and cardio-hepato-histopathology of female Sprague Dawley rats.
  
  
  METHODS
  Doxorubicin and ChEE (5 rats per group) were administered in five groups of 3 rats each for 11 d. Group I: doxorubicin (dox) 4.67 mg/kg body weight; Group II: dox+ChEE 500 mg/kg body weight; Group III: dox+ChEE 1 000 mg/kg body weight; Group IV: ChEE 1 000 mg/kg body weight; Group V: untreated (control).
  
  
  RESULTS
  ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats, but did not repair neither hepatohistopathology profile nor reduce serum activity of ALT and AST.
  
  
  CONCLUSIONS
  ChEE has potency to be developed as cardioprotector agent in chemotherapy.
authors: Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara II, Yogyakarta, Indonesia, 55281.
authors: Herwandhani
authors: H
authors: Putri
authors: Standie
authors: S
authors: Nagadi
authors: Yonika Arum
authors: YA
authors: Larasati
authors: Nindi
authors: N
authors: Wulandari
authors: Adam
authors: A
authors: Hermawan
authors: Agung Endo
authors: AE
authors: Nugroho
mesh_terms: D000410:Alanine Transaminase / Q000097:blood / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D002957:Citrus / Q000737:chemistry*; D004317:Doxorubicin / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D006321:Heart / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D004317:Doxorubicin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Cardiohepatoprotector; Chemoterapy; Citrus hystrix D.C.; Histopathology
references: J Card Fail. 2008 Nov;14(9):724-31
references: 18995176
references: Cardiol J. 2010;17(1):88-91
references: 20104463
references: Redox Rep. 2010;15(5):217-23
references: 21062537
references: Anticancer Drugs. 2006 Jan;17(1):81-7
references: 16317294
references: Molecules. 2012 May 30;17(6):6491-506
references: 22728349
references: Int J Biol Sci. 2009 Jun 28;5(5):466-73
references: 19584954
references: Food Chem Toxicol. 2009 Jul;47(7):1538-44
references: 19358873
references: J Endod. 2012 Feb;38(2):191-5
references: 22244634
references: Biosci Trends. 2012 Feb;6(1):19-25
references: 22426099
references: Toxicol Appl Pharmacol. 2012 May 15;261(1):66-73
references: 22712078
references: Asian Pac J Cancer Prev. 2011;12(10):2697-704
references: 22320977
references: Anticancer Drugs. 2011 Feb;22(2):176-84
references: 21218605
references: J Biol Chem. 2011 Feb 18;286(7):4991-5002
references: 21081502
references: Indian J Exp Biol. 2007 Dec;45(12):1045-9
references: 18254210
references: J Egypt Natl Canc Inst. 2005 Dec;17(4):291-300
references: 17102822
references: Biochim Biophys Acta. 2006 May-Jun;1757(5-6):553-61
references: 16678117
references: Pharmacol Rep. 2009 Jan-Feb;61(1):154-71
references: 19307704
references: Cancer Res. 2009 Apr 1;69(7):3205-12
references: 19318568
references: PLoS One. 2011;6(11):e27397
references: 22087308
references: J Egypt Natl Canc Inst. 2009 Jun;21(2):175-84
references: 21057569
references: Tex Heart Inst J. 2012;39(3):424-7
references: 22719160
references: Fundam Clin Pharmacol. 2011 Dec;25(6):682-9
references: 21105911