title: Lung toxicities of core-shell nanoparticles composed of carbon, cobalt, and silica.
abstract: We present here comparative assessments of murine lung toxicity (biocompatibility) after in vitro and in vivo exposures to carbon (C-SiO2-etched), carbon-silica (C-SiO2), carbon-cobalt-silica (C-Co-SiO2), and carbon-cobalt oxide-silica (C-Co3O4-SiO2) nanoparticles. These nanoparticles have potential applications in clinical medicine and bioimaging, and thus their possible adverse events require thorough investigation. The primary aim of this work was to explore whether the nanoparticles are biocompatible with pneumatocyte bioenergetics (cellular respiration and adenosine triphosphate content). Other objectives included assessments of caspase activity, lung structure, and cellular organelles. Pneumatocyte bioenergetics of murine lung remained preserved after treatment with C-SiO2-etched or C-SiO2 nanoparticles. C-SiO2-etched nanoparticles, however, increased caspase activity and altered lung structure more than C-SiO2 did. Consistent with the known mitochondrial toxicity of cobalt, both C-Co-SiO2 and C-Co3O4-SiO2 impaired lung tissue bioenergetics. C-Co-SiO2, however, increased caspase activity and altered lung structure more than C-Co3O4-SiO2. The results indicate that silica shell is essential for biocompatibility. Furthermore, cobalt oxide is the preferred phase over the zerovalent Co(0) phase to impart biocompatibility to cobalt-based nanoparticles.
authors: Department of Pediatrics, United Arab Emirates University, Abu Dhabi, United Arab Emirates.
authors: Mohammed T
authors: MT
authors: Al Samri
authors: Rafael
authors: R
authors: Silva
authors: Saeeda
authors: S
authors: Almarzooqi
authors: Alia
authors: A
authors: Albawardi
authors: Aws Rashad Diab
authors: AR
authors: Othman
authors: Ruqayya S M S
authors: RS
authors: Al Hanjeri
authors: Shaikha Km
authors: SK
authors: Al Dawaar
authors: Saeed
authors: S
authors: Tariq
authors: Abdul-Kader
authors: AK
authors: Souid
authors: Tewodros
authors: T
authors: Asefa
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D002244:Carbon / Q000737:chemistry / Q000633:toxicity*; D053148:Caspase 3 / Q000378:metabolism; D003035:Cobalt / Q000737:chemistry / Q000633:toxicity*; D008168:Lung / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D008297:Male; D008422:Materials Testing; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D012119:Respiration / Q000187:drug effects; D012822:Silicon Dioxide / Q000737:chemistry / Q000633:toxicity*; D018709:Statistics, Nonparametric
chemical_list: D003035:Cobalt; D002244:Carbon; D012822:Silicon Dioxide; D053148:Caspase 3
keywords: biocompatibility; carbon nanoparticles; cobalt nanoparticles; cobalt oxide nanoparticles; nanotoxicology; silica nanoparticles
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