title: Role of the gustatory thalamus in taste learning.
abstract: The present study re-examined the involvement of the gustatory thalamus (GT) in the acquisition of drug- and toxin-induced conditioned taste aversions (CTAs) using a standardized procedure involving 15-min taste trials in rats injected with morphine (Experiment 1), lithium chloride (Experiment 2) or amphetamine (Experiment 3). Contrary to previous results, GT lesions did not eliminate drug-induced CTAs. Rather, GT-lesioned rats acquired aversions of comparable magnitude to non-lesioned subjects but from an elevated intake on the first conditioning trial. A similar pattern of lesion effects was found in the acquisition of an illness-induced CTA. Thus, we conclude that GT lesions do not differentially influence CTAs conditioned with drugs or toxins. The lesion-induced elevated intake of a novel tastant confirms an unappreciated role for the GT in taste neophobia.
authors: University of Illinois at Chicago, IL 60607,United States.
authors: Joe
authors: J
authors: Arthurs
authors: Steve
authors: S
authors: Reilly
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000661:Amphetamine / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D018692:Antimanic Agents / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology*; D004326:Drinking / Q000187:drug effects; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity; D005508:Food Deprivation / Q000502:physiology; D018021:Lithium Chloride / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology; D016202:N-Methylaspartate / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013649:Taste / Q000187:drug effects / Q000502:physiology*; D013788:Thalamus / Q000187:drug effects / Q000293:injuries / Q000502:physiology*
chemical_list: D000701:Analgesics, Opioid; D018692:Antimanic Agents; D000697:Central Nervous System Stimulants; D018690:Excitatory Amino Acid Agonists; D016202:N-Methylaspartate; D009020:Morphine; D000661:Amphetamine; D018021:Lithium Chloride
references: Behav Neurosci. 1996 Aug;110(4):737-45
references: 8864265
references: Behav Neurosci. 1992 Feb;106(1):217-28
references: 1554433
references: Physiol Behav. 2006 Mar 30;87(3):542-51
references: 16458940
references: Behav Brain Res. 2002 Oct 17;136(1):143-50
references: 12385799
references: Brain Res Bull. 2003 Dec 15;62(2):117-28
references: 14638385
references: Behav Neurosci. 2008 Oct;122(5):1051-60
references: 18823162
references: Am J Physiol. 1996 Apr;270(4 Pt 2):R793-800
references: 8967409
references: Ann N Y Acad Sci. 1989;575:106-19; discussion 120-1
references: 2699182
references: Neurosci Res. 1995 Mar;22(1):31-49
references: 7792081
references: Behav Neurosci. 1993 Apr;107(2):317-26
references: 8484896
references: Behav Neurosci. 1998 Jun;112(3):678-94
references: 9676983
references: Behav Neurosci. 1991 Dec;105(6):933-43
references: 1663764
references: Physiol Behav. 1981 Jun;26(6):1031-5
references: 6792637
references: Physiol Behav. 1978 May;20(5):653-5
references: 684100
references: Nat Rev Neurosci. 2011 Oct 05;12(11):685-700
references: 21971065
references: Physiol Behav. 2001 Apr;72(5):735-42
references: 11337006
references: Behav Brain Res. 2006 Jun 3;170(1):34-40
references: 16530861
references: Ann N Y Acad Sci. 1985;443:1-441
references: 3860067
references: Behav Neurosci. 1996 Aug;110(4):746-59
references: 8864266
references: Neurosci Res. 2000 Apr;36(4):297-309
references: 10771108
references: Br J Psychol. 1958 Aug;49(3):195-201
references: 13572791
references: Brain Res. 2011 Apr 12;1384:80-8
references: 21300039
references: Behav Brain Res. 2012 Dec 1;235(2):182-8
references: 22884404
references: J Comp Physiol Psychol. 1981 Aug;95(4):565-87
references: 7276281
references: J Comp Physiol Psychol. 1974 Oct;87(4):622-43
references: 4426986
references: Physiol Behav. 2012 Jun 25;106(4):515-9
references: 22484563
references: Brain Res. 2009 Jan 28;1251:195-203
references: 19059225
references: Brain Res. 2000 Mar 10;858(2):327-37
references: 10708684
references: Brain Res. 2012 Apr 11;1448:82-8
references: 22405689
references: Behav Neurosci. 2007 Feb;121(1):90-9
references: 17324053
references: Brain Res. 2009 Mar 9;1259:68-73
references: 19150440
references: Physiol Behav. 1981 Sep;27(3):397-400
references: 7335779
references: Eur J Neurosci. 2007 Nov;26(9):2627-32
references: 17970726
references: Brain Res Bull. 1999 Feb;48(3):239-54
references: 10229331
references: Behav Neurosci. 2012 Jun;126(3):423-32
references: 22428901
references: J Comp Physiol Psychol. 1977 Jun;91(3):498-507
references: 874118
references: Q J Exp Psychol (Hove). 2009 Jan;62(1):9-17
references: 18622888
references: Prog Neurobiol. 1998 Jun;55(3):257-332
references: 9643556
references: J Comp Neurol. 1998 Oct 5;399(4):440-68
references: 9741477
references: Brain Res. 1986 Aug 6;379(2):329-41
references: 3742225
references: Neurosci Biobehav Rev. 1998 Oct;22(6):883-901
references: 9809317
references: Brain Res. 2009 Oct 6;1292:52-60
references: 19631620
references: Behav Neurosci. 1999 Oct;113(5):1008-19
references: 10571483
references: Behav Neurosci. 2012 Jun;126(3):433-44
references: 22409482
references: Behav Neurosci. 2005 Aug;119(4):983-1003
references: 16187827
references: Behav Neurosci. 1991 Dec;105(6):944-54
references: 1777107
references: Behav Neurosci. 1997 Jun;111(3):633-45
references: 9189278
references: Am J Physiol. 1998 Jun;274(6):R1687-703
references: 9608024
references: Behav Neurosci. 2003 Jun;117(3):606-15
references: 12802888
references: Q J Exp Psychol (Hove). 2012;65(3):371-94
references: 22404646