title: [Study on synergistic effect of bactericidal effect of chlorine dioxide solution by surfactant].
abstract: OBJECTIVE
  To study the effect of gemini fluorocarbon, sodium p-perfluorous nonenoxybenzene sulfonate and sodium dodecyl sulfate on the chlorine dioxide solution sterilization to object surface.
  
  
  METHODS
  Pure chlorine dioxide solution as the reference disinfectant, carrier quantitative bactericidal test and simulated test on-site were used to carry out laboratory observation according to The disinfection technical specifications (2002).
  
  
  RESULTS
  Carrier quantitative bactericidal test showed that the addition dosage of gemini fluoronates, sodium dodecyl sulfate surfactant and perfluorinated the nonene oxy benzene sulfonate in disinfectant solution were 60, 60 and 40 mg/L respectively, the killing log value of Staphylococcus aureus exposed to the disinfectant solution containing chlorine dioxide 50 mg/L for 10 mm were all more than 3; and the addition dosage of gemini fluorinates, sodium dodecyl sulfate and perfluorinated the nonene oxy benzene sulfonate in disinfectant solution were 60 mg/L, the killing log value of Escherichia coli exposed to the disinfectant solution containing chlorine dixoxide 20 mg/L for 10 min were all more than 3. The bactericidal effect of the mixture use of surfactant and chlorine dioxide was better than the single use of chlorine dioxide. The simulated test on-site showed that the killing log value of Escherichia coli exposed to the disinfectant solution containing perfluorinated the nonene oxy benzene sulfonate 40 mg/L and chlorine dioxide 20 mg/L for 15 min was more than 3.
  
  
  CONCLUSIONS
  Surface active agent on germicidal efficacy of chlorine dioxide solution had synergistic action.
authors: College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Hehei Province Key Laboratory of Molecular Medicinal Chemistry, Hebei Drug Chemical Engineering Technology Research Center, Shijiazhuang 050018, China. xiaoyuan41@126.com
authors: Kuitao
authors: K
authors: Wang
authors: Vuena
authors: V
authors: Tian
authors: Na
authors: N
authors: Gu
authors: Congjing
authors: C
authors: Zhang
authors: Jiajing
authors: J
authors: Niu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002117:Calcitriol / Q000031:analogs & derivatives / Q000494:pharmacology; D017606:Chlorine Compounds / Q000494:pharmacology*; D004357:Drug Synergism; D010087:Oxides / Q000494:pharmacology*; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013501:Surface-Active Agents / Q000494:pharmacology*
chemical_list: C411462:1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3); D000900:Anti-Bacterial Agents; D017606:Chlorine Compounds; D010087:Oxides; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; C025109:chlorine dioxide; D002117:Calcitriol