title: Congenital neuroblastoma in a neonate with isotretinoin embryopathy.
abstract: We describe a neonate with isotretinoin embryopathy and an incidental finding of congenital neuroblastoma. Diffuse liver metastases led to the decision to provide oncologic therapy followed by tumor resection. Despite the possible need for chronic care related to the comorbidities of the isotretinoin embryopathy and oncologic management, the patient remains disease-free. Because of the uncertain etiology of neuroblastoma, it remains unclear whether exposure to isotretinoin during embryogenesis and fetal development had an oncogenic effect on this patient.
authors: *Texas Children's Cancer Center †Department of Pathology, Baylor College of Medicine, Houston, TX.
authors: Shiley
authors: S
authors: Aguilar
authors: Chrystal
authors: C
authors: Louis
authors: John
authors: J
authors: Hicks
authors: Peter
authors: P
authors: Zage
authors: Heidi
authors: H
authors: Russell
mesh_terms: D000014:Abnormalities, Drug-Induced; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000151:congenital* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D015474:Isotretinoin / Q000009:adverse effects*; D009447:Neuroblastoma / Q000150:complications* / Q000151:congenital* / Q000473:pathology
chemical_list: D015474:Isotretinoin