title: Sleep and the single neuron: the role of global slow oscillations in individual cell rest.
abstract: Sleep is universal in animals, but its specific functions remain elusive. We propose that sleep's primary function is to allow individual neurons to perform prophylactic cellular maintenance. Just as muscle cells must rest after strenuous exercise to prevent long-term damage, brain cells must rest after intense synaptic activity. We suggest that periods of reduced synaptic input ('off periods' or 'down states') are necessary for such maintenance. This in turn requires a state of globally synchronized neuronal activity, reduced sensory input and behavioural immobility - the well-known manifestations of sleep.
authors: University of Surrey, Faculty of Health and Medical Sciences, Department of Biochemistry and Physiology, Guildford, GU2 7XH, UK. vyazovskiy@gmail.com
authors: Vladyslav V
authors: VV
authors: Vyazovskiy
authors: Kenneth D
authors: KD
authors: Harris
mesh_terms: D000818:Animals; D058256:Brain Waves / Q000502:physiology*; D002468:Cell Physiological Phenomena; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D012146:Rest / Q000502:physiology*; D012890:Sleep / Q000502:physiology*
references: Neuroscience. 2008 Sep 22;156(1):71-80
references: 18694809
references: Cereb Cortex. 2010 Nov;20(11):2660-74
references: 20200108
references: Nat Rev Neurosci. 2011 Aug 10;12(9):509-23
references: 21829219
references: Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15939-44
references: 20696898
references: J Neurochem. 2001 Nov;79(3):463-84
references: 11701750
references: Brain Res Bull. 1993;31(1-2):97-113
references: 8453498
references: Prog Neurobiol. 2008 Nov;86(3):264-80
references: 18809461
references: J Sleep Res. 2000 Dec;9(4):367-71
references: 11123523
references: Am J Physiol. 1997 Aug;273(2 Pt 2):R472-8
references: 9277528
references: Neuron. 2006 Dec 7;52(5):871-82
references: 17145507
references: Sleep. 2010 Dec;33(12):1659-67
references: 21120128
references: J Neurosci. 2013 Jan 2;33(1):227-33
references: 23283336
references: Front Synaptic Neurosci. 2010 Oct 05;2:135
references: 21423521
references: Science. 2012 Aug 17;337(6096):839-42
references: 22859819
references: Sleep. 1995 Dec;18(10):890-4
references: 8746397
references: Nat Neurosci. 2007 Mar;10(3):385-92
references: 17293859
references: Nat Neurosci. 2010 Jan;13(1):9-17
references: 19966841
references: Hum Neurobiol. 1982;1(3):195-204
references: 7185792
references: J Neurosci. 2007 Sep 26;27(39):10597-607
references: 17898231
references: J Biol Chem. 1970 Mar 25;245(6):1388-93
references: 5442826
references: Neuron. 2011 Apr 14;70(1):153-69
references: 21482364
references: Neuropsychopharmacology. 2004 Oct;29(10):1933-9
references: 15257305
references: Prog Brain Res. 2010;185:105-29
references: 21075236
references: J Neurosci. 1999 Jun 1;19(11):4595-608
references: 10341257
references: Physiol Rev. 2008 Oct;88(4):1243-76
references: 18923182
references: Free Radic Biol Med. 1991;11(3):239-46
references: 1937141
references: Dev Neurobiol. 2012 Jan;72(1):134-44
references: 21563316
references: Neurobiol Learn Mem. 2011 Nov;96(4):564-82
references: 21875679
references: Neuroscience. 2002;114(4):1047-60
references: 12379258
references: Nature. 2011 Apr 28;472(7344):443-7
references: 21525926
references: Epilepsia. 2011 Oct;52 Suppl 8:25-7
references: 21967355
references: Brain Res. 2000 Dec 8;885(2):303-21
references: 11102586
references: Nat Rev Neurosci. 2010 Feb;11(2):114-26
references: 20046194
references: Behav Brain Res. 1995 Jul-Aug;69(1-2):91-6
references: 7546322
references: Nature. 2004 Dec 9;432(7018):758-61
references: 15592414
references: Sleep Med Rev. 2006 Feb;10(1):49-62
references: 16376591
references: PM R. 2010 May;2(5):347-58
references: 20656616
references: Brain Res. 2005 Jul 19;1050(1-2):64-71
references: 15975563
references: Am J Physiol. 1991 Jul;261(1 Pt 2):R198-208
references: 1858947
references: Ergeb Physiol. 1972;64:1-165
references: 4340664
references: Neurosci Lett. 1997 Dec 19;239(2-3):121-4
references: 9469671
references: J Gen Physiol. 1960 Jul;43(6)Suppl:177-95
references: 13841952
references: Cereb Cortex. 2006 Mar;16(3):328-36
references: 15901653
references: J Sleep Res. 2013 Jun;22(3):239-50
references: 23607417
references: Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):347-52
references: 17185420
references: Lancet Neurol. 2013 Jan;12(1):105-18
references: 23237905
references: J Cell Physiol. 2002 Jul;192(1):1-15
references: 12115731
references: Sleep Res Online. 1999;2(3):65-9
references: 11382884
references: Exerc Sport Sci Rev. 2002 Jan;30(1):45-9
references: 11800500
references: Prog Brain Res. 2011;193:93-110
references: 21854958
references: J Neurochem. 2005 Mar;92(5):1150-7
references: 15715665
references: Neuroreport. 1996 Dec 20;8(1):123-7
references: 9051765
references: Neuron. 2011 Oct 6;72(1):153-65
references: 21982376
references: Sleep. 2003 Mar 15;26(2):117-26
references: 12683469
references: Neurophysiol Clin. 2010 May;40(2):59-124
references: 20510792
references: Sleep Med. 2007 Jun;8(4):349-72
references: 17470413
references: Nature. 2005 Oct 27;437(7063):1264-71
references: 16251951
references: Science. 1997 May 23;276(5316):1265-8
references: 9157887
references: J Sleep Res. 2012 Dec;21(6):603-11
references: 22676149
references: Science. 2009 Nov 13;326(5955):1005-7
references: 19779148
references: Neuropharmacology. 2012 Oct;63(5):806-17
references: 22722023
references: Sleep. 2011 Mar 01;34(3):283-91A
references: 21358845
references: Electroencephalogr Clin Neurophysiol. 1986 Jul;64(1):74-6
references: 2424723
references: Annu Rev Physiol. 2005;67:225-57
references: 15709958
references: J Neurophysiol. 1970 Sep;33(5):672-84
references: 4318175
references: J Neurophysiol. 2010 Sep;104(3):1314-24
references: 20554835
references: J Neurosci. 2009 Aug 19;29(33):10309-20
references: 19692605
references: Sleep. 2010 Apr;33(4):475-80
references: 20394316
references: Nature. 2012 Nov 22;491(7425):547-53
references: 23172213
references: J Neurophysiol. 2005 Jan;93(1):281-93
references: 15306631
references: Neurochem Res. 1979 Feb;4(1):37-52
references: 450172
references: J Sleep Res. 1992 Mar;1(1):40-44
references: 10607024
references: Neuron. 2009 Sep 24;63(6):865-78
references: 19778514
references: Nat Rev Neurosci. 2008 Dec;9(12):910-9
references: 18985047
references: Nature. 2006 Nov 30;444(7119):610-3
references: 17086200
references: Cell Metab. 2011 Feb 2;13(2):160-9
references: 21284983
references: J Neurosci. 2010 Mar 10;30(10):3745-51
references: 20220008
references: Sleep. 2004 Feb 1;27(1):27-35
references: 14998234
references: Curr Top Med Chem. 2011;11(19):2490-2
references: 21906015
references: Int J Dev Neurosci. 2007 Nov;25(7):455-63
references: 17913437
references: PLoS One. 2012;7(12):e50677
references: 23227197
references: J Neurophysiol. 2007 Jun;97(6):4186-202
references: 17409168
references: J Sleep Res. 2005 Sep;14(3):299-304
references: 16120105
references: Nat Neurosci. 2011 Oct 09;14(11):1418-20
references: 21983682
references: Nature. 2002 May 16;417(6886):287-91
references: 12015603
references: Eur J Neurosci. 2009 May;29(9):1830-41
references: 19473236
references: Neuroscientist. 2006 Oct;12(5):410-24
references: 16957003
references: Front Biosci. 2003 May 01;8:d520-50
references: 12700031
references: J Cell Sci. 2012 May 1;125(Pt 9):2105-14
references: 22627029
references: Physiol Rev. 2008 Jan;88(1):287-332
references: 18195089
references: Nat Rev Neurosci. 2012 May 18;13(6):407-20
references: 22595786
references: Sleep. 2007 Dec;30(12):1643-57
references: 18246974
references: Sleep. 2010 Jul;33(7):879-87
references: 20614848
references: Neuroscience. 2009 Sep 29;163(1):415-29
references: 19540312
references: PLoS One. 2013;8(1):e54491
references: 23359526
references: Clin Neurophysiol. 1999 Dec;110(12):2148-52
references: 10616120
references: Nat Neurosci. 2009 Nov;12(11):1444-9
references: 19801988
references: Sleep Med. 2007 Dec;8 Suppl 4:S27-34
references: 18346674
references: Int Rev Neurobiol. 1993;35:131-60
references: 8096499
references: Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2065-9
references: 12576550
references: J Neurophysiol. 1996 Dec;76(6):4152-68
references: 8985908
references: Am J Physiol. 1995 Feb;268(2 Pt 2):R549-61
references: 7864252
references: Electroencephalogr Clin Neurophysiol. 1971 Feb;30(2):97-112
references: 4100287
references: Brain Res. 1977 Oct 14;134(3):581-4
references: 902119
references: J Neurophysiol. 2009 Apr;101(4):1921-31
references: 19164101
references: Neural Plast. 2012;2012:415250
references: 22619736
references: Rev Neurosci. 2006;17(4):375-92
references: 17139839
references: Trends Neurosci. 2011 Jan;34(1):10-9
references: 21030095
references: J Neurosci. 2007 Sep 5;27(36):9607-22
references: 17804621
references: Nat Neurosci. 2003 Jun;6(6):553-4
references: 12754515
references: Science. 2010 Sep 24;329(5999):1663-7
references: 20798282
references: Physiol Rev. 2012 Jul;92(3):1087-187
references: 22811426
references: J Neurophysiol. 2002 Nov;88(5):2280-6
references: 12424269
references: Prog Neurobiol. 1995 Mar;45(4):347-60
references: 7624482
references: Neuron. 2003 Mar 27;37(6):925-37
references: 12670422
references: Am J Physiol. 1990 Mar;258(3 Pt 2):R634-44
references: 2316711
references: Proc R Soc Lond B Biol Sci. 1979 Dec 31;206(1164):281-91
references: 43974
references: Neuron. 2010 Dec 22;68(6):1023-42
references: 21172606
references: J Physiol. 2006 May 1;572(Pt 3):707-20
references: 16439431
references: Arch Ital Biol. 2001 Apr;139(3):253-67
references: 11330205
references: Science. 1994 Jul 29;265(5172):676-9
references: 8036517
references: J Neurosci. 2010 Mar 24;30(12):4440-8
references: 20335480
references: J Neurosci. 2006 May 24;26(21):5665-72
references: 16723523
references: Science. 1996 Nov 15;274(5290):1133-8
references: 8895456
references: J Neurosci. 2013 Jan 23;33(4):1684-95
references: 23345241
references: Cell Calcium. 2003 Oct-Nov;34(4-5):325-37
references: 12909079
references: Front Physiol. 2012 Jun 01;3:151
references: 22675303
references: Science. 2011 Nov 25;334(6059):1081-6
references: 22116877
references: Neuroscience. 2000;101(3):523-9
references: 11113301
references: J Sleep Res. 2003 Mar;12(1):25-34
references: 12603784
references: Semin Neurol. 2009 Sep;29(4):320-39
references: 19742409
references: Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13638-43
references: 14595013
references: Antioxid Redox Signal. 2011 Nov 1;15(9):2487-99
references: 21375476
references: Nat Neurosci. 2008 May;11(5):535-7
references: 18376400
references: Sleep. 2010 Jul;33(7):889-900
references: 20614849
references: J Neurosci. 2011 Apr 27;31(17):6414-20
references: 21525282
references: Trends Neurosci. 2006 Jul;29(7):414-418
references: 16713634
references: J Sleep Res. 1998;7 Suppl 1:17-23
references: 9682189
references: J Biol Chem. 2005 Oct 7;280(40):33917-25
references: 16107336
references: J Neurosci. 2001 Apr 15;21(8):2610-21
references: 11306614
references: J Neurochem. 2008 Jul;106(2):978-88
references: 18466333
references: J Appl Physiol (1985). 2008 Feb;104(2):551-8
references: 18162480
references: Brain Res. 2001 Sep 21;913(2):220-3
references: 11549390
references: Sleep. 2004 Jun 15;27(4):774-83
references: 15283014
references: Rev Electroencephalogr Neurophysiol Clin. 1971 Jan-Mar;1(1):95-9
references: 5173705
references: Ann N Y Acad Sci. 2001 Mar;933:211-21
references: 12000022
references: Circ Res. 2010 Nov 12;107(10):1185-97
references: 21071716
references: J Neurosci. 2010 Oct 6;30(40):13211-9
references: 20926647
references: J Cell Mol Med. 2011 Oct;15(10):2025-39
references: 21722302
references: Sleep. 2004 Nov 1;27(7):1255-73
references: 15586779
references: Neuron. 2004 Jan 8;41(1):35-43
references: 14715133
references: J Comput Neurosci. 2010 Aug;29(1-2):49-62
references: 20225075
references: J Physiol. 2011 May 1;589(Pt 9):2119-27
references: 21041533
references: J Neurophysiol. 2000 Oct;84(4):1888-93
references: 11024081
references: Nat Neurosci. 2007 Jan;10(1):100-7
references: 17173043
references: J Neurosci. 1995 Oct;15(10):6301-13
references: 7472396
references: Nat Neurosci. 2006 May;9(5):608-10
references: 16617340
references: J Neurophysiol. 2001 May;85(5):1969-85
references: 11353014
references: J Neurosci. 2008 Nov 26;28(48):12614-21
references: 19036955
references: Am J Physiol. 1984 Feb;246(2 Pt 2):R161-83
references: 6696142
references: Neuroreport. 1997 Jul 28;8(11):2557-60
references: 9261826
references: J Neurophysiol. 2004 Dec;92(6):3511-21
references: 15254074
references: Brain Res. 2010 Mar 4;1317:13-23
references: 20045396
references: Nature. 2008 Aug 14;454(7206):881-5
references: 18633351
references: Dev Psychobiol. 2013 Jan;55(1):92-100
references: 22711221
references: Learn Mem. 2004 Nov-Dec;11(6):697-704
references: 15576887
references: J Sleep Res. 1994 Sep;3(3):159-164
references: 10607121
references: Neuroscience. 2004;124(2):481-8
references: 14980397
references: Sleep. 2013 Jan 01;36(1):59-72
references: 23288972
references: Brain Res Bull. 2007 Sep 14;74(1-3):37-44
references: 17683787
references: J Neurosci. 1997 Jun 15;17(12):4800-8
references: 9169538
references: Int J Dev Neurosci. 1986;4(3):209-15
references: 3455586
references: J Physiol. 2012 Aug 15;590(16):3987-4010
references: 22641778
references: PLoS One. 2012;7(9):e45987
references: 23029352
references: Brain Res. 2000 Dec 15;886(1-2):208-223
references: 11119697
references: J Sleep Res. 1993 Jun;2(2):63-69
references: 10607073
references: Neuroscientist. 2012 Oct;18(5):533-46
references: 22572533
references: Neuroscience. 2003;116(1):187-200
references: 12535952
references: Nat Rev Neurosci. 2005 Nov;6(11):841-9
references: 16261178
references: J Neurophysiol. 1994 Jan;71(1):17-32
references: 8158226
references: Neuron. 2011 Mar 24;69(6):1061-8
references: 21435553
references: Mol Cell. 2010 Oct 22;40(2):253-66
references: 20965420
references: Neurosci Bull. 2012 Feb;28(1):25-38
references: 22233887
references: Electroencephalogr Clin Neurophysiol. 1949 Aug;1(3):265-72
references: 18135418
references: PLoS Biol. 2008 Aug 26;6(8):e216
references: 18752355
references: EMBO J. 2011 May 17;30(13):2520-31
references: 21587205
references: Neuron. 2006 Dec 7;52(5):748-9
references: 17145497
references: Sleep. 1992 Apr;15(2):102-18
references: 1579784
references: Sleep Med Clin. 2011 Mar 1;6(1):71-84
references: 21339852
references: Med Hypotheses. 1994 Oct;43(4):231-3
references: 7838006
references: J Neurosci. 2004 Aug 4;24(31):6862-70
references: 15295020
references: J Neurosci. 2012 Sep 5;32(36):12506-17
references: 22956841
references: Neural Plast. 2012;2012:264378
references: 22530156
references: Curr Top Med Chem. 2011;11(19):2414-22
references: 21906023
references: Thalamus Relat Syst. 2005 Dec;3(4):245-259
references: 18185848
references: Nature. 2004 Jul 1;430(6995):78-81
references: 15184907
references: Eur J Neurosci. 2004 Sep;20(5):1363-70
references: 15341608
references: J Neurophysiol. 2008 Feb;99(2):969-75
references: 18077659
references: Brain Res. 1999 Sep 4;840(1-2):184-93
references: 10517970
references: Physiol Genomics. 2007 Nov 14;31(3):441-57
references: 17698924