title: Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila.
abstract: Dosage compensation has arisen in response to the evolution of distinct male (XY) and female (XX) karyotypes. In Drosophila melanogaster, the MSL complex increases male X transcription approximately twofold. X-specific targeting is thought to occur through sequence-dependent binding to chromatin entry sites (CESs), followed by spreading in cis to active genes. We tested this model by asking how newly evolving sex chromosome arms in Drosophila miranda acquired dosage compensation. We found evidence for the creation of new CESs, with the analogous sequence and spacing as in D. melanogaster, providing strong support for the spreading model in the establishment of dosage compensation.
authors: Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
authors: Artyom A
authors: AA
authors: Alekseyenko
authors: Christopher E
authors: CE
authors: Ellison
authors: Andrey A
authors: AA
authors: Gorchakov
authors: Qi
authors: Q
authors: Zhou
authors: Vera B
authors: VB
authors: Kaiser
authors: Nick
authors: N
authors: Toda
authors: Zaak
authors: Z
authors: Walton
authors: Shouyong
authors: S
authors: Peng
authors: Peter J
authors: PJ
authors: Park
authors: Doris
authors: D
authors: Bachtrog
authors: Mitzi I
authors: MI
authors: Kuroda
mesh_terms: D000818:Animals; D004303:Dosage Compensation, Genetic; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics* / Q000378:metabolism*; D019143:Evolution, Molecular; D005260:Female; D059785:Karyotype; D008297:Male; D008969:Molecular Sequence Data; D012730:Sex Chromosomes / Q000235:genetics* / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins
references: PLoS Genet. 2012;8(4):e1002646
references: 22570616
references: Genes Dev. 2005 Oct 1;19(19):2284-8
references: 16204179
references: Bioinformatics. 2011 Feb 15;27(4):578-9
references: 21149342
references: Nat Struct Mol Biol. 2008 Dec;15(12):1318-25
references: 19029895
references: EMBO J. 1997 Apr 15;16(8):2054-60
references: 9155031
references: Mol Cell. 2007 Oct 12;28(1):121-33
references: 17936709
references: Genome Res. 2008 Jan;18(1):188-96
references: 18025269
references: Genetics. 1996 Oct;144(2):705-13
references: 8889531
references: Genetics. 2008 Oct;180(2):1123-9
references: 18780755
references: Genome Biol. 2008;9(2):R30
references: 18269752
references: Proc Natl Acad Sci U S A. 1978 Feb;75(2):931-5
references: 273254
references: Cell. 1999 Aug 20;98(4):513-22
references: 10481915
references: Nature. 2002 Mar 21;416(6878):323-6
references: 11907578
references: Mol Cell Biol. 2008 May;28(10):3401-9
references: 18347056
references: Genes Dev. 2006 Apr 1;20(7):858-70
references: 16547172
references: Nature. 1996 Sep 12;383(6596):160-3
references: 8774878
references: Science. 2012 Jul 20;337(6092):341-5
references: 22822149
references: Science. 2004 Feb 20;303(5661):1182-5
references: 14976312
references: PLoS Genet. 2008 Dec;4(12):e1000302
references: 19079572
references: Genome Biol. 2009;10(3):R25
references: 19261174
references: Genetics. 2007 Nov;177(3):1959-62
references: 18039888
references: Nature. 2011 Mar 3;471(7336):115-8
references: 21368835
references: Cell. 1997 Feb 21;88(4):445-57
references: 9038336
references: J Biol Chem. 2001 Aug 24;276(34):31483-6
references: 11445559
references: Proc Natl Acad Sci U S A. 1978 Nov;75(11):5618-22
references: 281711
references: Genes Dev. 2005 Oct 1;19(19):2289-94
references: 16204180
references: EMBO J. 2002 Mar 1;21(5):1084-91
references: 11867536
references: Cell. 2008 Aug 22;134(4):599-609
references: 18724933
references: Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7591-5
references: 1323846
references: Genes Dev. 2006 Apr 1;20(7):848-57
references: 16547173
references: Chromosome Res. 1996 Apr;4(3):185-90
references: 8793201
references: Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15412-7
references: 17878295
references: Genome Biol. 2008;9(9):R137
references: 18798982
references: Science. 1978 Nov 17;202(4369):711-6
references: 715437
references: BMC Bioinformatics. 2007 Feb 26;8:64
references: 17324286
references: Cell. 1992 Apr 17;69(2):375-84
references: 1568251
references: Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1513-8
references: 21187386
references: Nucleic Acids Res. 2009 Jul;37(Web Server issue):W202-8
references: 19458158
references: Genome Res. 2012 Oct;22(10):1864-76
references: 22948768
references: Genes Dev. 1994 Jan;8(1):96-104
references: 8288132