title: Micronutrients-incorporated calcium phosphate particles with protective effect on osteoporotic bone tissue.
abstract: BACKGROUND
  Supplementation of individual micronutrient is inadequate for maintaining bone function because single micronutrient can not contribute significantly a positive remodeling balance.
  
  
  OBJECTIVE
  We developed the highly integrated, stably dietary multi-micronutrients with good bioavailability and low adverse effect on the improvement of bone consolidation in osteoporosis.
  
  
  METHODS
  The trace element-codoped calcium phosphate (teCaP) particles were prepared in the modified body fluid and carefully evaluated. Rats, aged 3 months, were ovariectomized and when 6 month intervened with the conditioned, low, moderate, and high teCaP diets.
  
  
  RESULTS
  The teCaP particles showed highly dissolvable in stomach juice-mimicing acidic solutions. Three months after intervention, the body weight increase showed remarkable differences among the low teCaP diet (~52 g), moderate teCaP diet (~34 g) and high teCaP diet (~23 g) group. In particular, the intake of moderate teCaP greatly improved the retention of trace elements in femural bone for better protection against the skeletal weakening, and resulted in a significant increase of bone mineral density (104.06%) in comparison with the conventional high calcium plus vitamin D3 diet (Control group).
  
  
  CONCLUSIONS
  These investigations improve our understanding of micronutrient retention on bone consolidation in osteoporotic bone tissue, and also provide new mild wet-chemical approach to prepare potent nutritionally effective edible complements to synergistically relieve bone degeneration and prevent osteoporosis.
authors: Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou 310029, China.
authors: X
authors: X
authors: Chen
authors: L
authors: L
authors: Zhang
authors: X
authors: X
authors: Yang
authors: Z
authors: Z
authors: Li
authors: X
authors: X
authors: Sun
authors: M
authors: M
authors: Lin
authors: G
authors: G
authors: Yang
authors: Z
authors: Z
authors: Gou
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D002136:Calcium, Dietary / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D019587:Dietary Supplements; D016503:Drug Delivery Systems; D005260:Female; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D005750:Gastric Juice; D010024:Osteoporosis / Q000378:metabolism / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D014131:Trace Elements / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D050071:Bone Density Conservation Agents; D002130:Calcium Phosphates; D002136:Calcium, Dietary; D014131:Trace Elements; C020243:calcium phosphate
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