title: Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria.
abstract: Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.
authors: University of California, San Diego, La Jolla, CA, USA
authors: A Taylor
authors: AT
authors: Bright
authors: Thamer
authors: T
authors: Alenazi
authors: Sandra
authors: S
authors: Shokoples
authors: Joel
authors: J
authors: Tarning
authors: Giacomo M
authors: GM
authors: Paganotti
authors: Nicholas J
authors: NJ
authors: White
authors: Stanley
authors: S
authors: Houston
authors: Elizabeth A
authors: EA
authors: Winzeler
authors: Stephanie K
authors: SK
authors: Yanow
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D001711:Biotransformation; D002738:Chloroquine / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D004361:Drug Tolerance / Q000235:genetics*; D018503:Genome, Protozoan; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D016780:Malaria, Vivax / Q000188:drug therapy / Q000378:metabolism* / Q000469:parasitology; D008297:Male; D010966:Plasmodium vivax / Q000187:drug effects / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011319:Primaquine / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D012008:Recurrence; D017422:Sequence Analysis, DNA
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D011319:Primaquine
keywords: Plasmodium vivax; genetics; malaria; parasites; primaquine; relapse
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