title: Fibrosis in hepatitis C patients predicts complications after elective total joint arthroplasty.
abstract: Effects of Hepatitis C on total hip (THA) and total knee arthroplasty (TKA) outcomes are poorly understood. Seventy-two hepatitis C patients underwent 77 primary THA or TKA and were retrospectively identified, stratified by fibrosis and thrombocytopenia and compared to matched controls. Overall, Hepatitis C and control patients had similar outcomes. After TKA, fibrotic hepatitis C patients demonstrated a greater average hemoglobin drop than non-fibrotic hepatitis C patients (4.9 versus 3.8, P=0.023), greater deep infection rate (21% versus 0%, P=0.047), and rate of cellulitis (21% versus 0%, P=0.047). Thrombocytopenia showed a trend toward greater infections. Prior to fibrosis, Hepatitis C patients appear to be at no increased risk of complication after joint arthroplasty. Evaluation of fibrosis may predict poor outcome in Hepatitis C patients.
authors: Jefferson Medical College, Dept. of Orthopaedic Surgery, Philadelphia, Pennsylvania.
authors: Fabio
authors: F
authors: Orozco
authors: Zachary D
authors: ZD
authors: Post
authors: Omkar
authors: O
authors: Baxi
authors: Adam
authors: A
authors: Miller
authors: Alvin
authors: A
authors: Ong
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D005260:Female; D005355:Fibrosis / Q000209:etiology; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007592:Joint Diseases / Q000150:complications / Q000601:surgery*; D008103:Liver Cirrhosis; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000209:etiology
keywords: Outcomes; complications; fibrosis; hepatitis C; total joint arthroplasty