title: Natural antiband 3 antibodies in patients with sickle cell disease.
abstract: Band 3 oligomers, precociously formed in the membrane of sickle red blood cells (SS RBC) as a result of oxidative damage, induce two significant changes: (1) contribution to the adhesive nature of these cells to endothelial cells; (2) production of recognition sites for natural antiband 3 antibodies (antiband 3 Nabs). The inhibition of the adhesion of SS RBC to endothelial cells by band 3 peptides suggests a participation of antiband 3 Nabs in the etiology and prevention of vaso-occlusive crises (VOC). To address this question, we measured the levels of antiband 3 Nabs in sickle cell anaemia (SCA) patients (45 in steady state, 35 in VOC) and in controls (27 sickle trait, 30 normal AA subjects). A significant decreased of antiband 3 Nabs in the VOC group was demonstrated as compared with the steady state group, the sickle trait and healthy controls. This study provides data suggesting that Antiband 3 Nabs are likely to play a role in the SCA VOC.
authors: Instituto de Hematología e Inmunología, Apartado Postal 8070, 10800 CP, Ciudad de La Habana, Cuba. rinaldo@infomed.sld.cu
authors: Rinaldo
authors: R
authors: Villaescusa
authors: Ada Amalia
authors: AA
authors: Arce
authors: Marie-Laure
authors: ML
authors: Lalanne-Mistrih
authors: Yann
authors: Y
authors: Lamarre
authors: Régine
authors: R
authors: Hierso
authors: Carlos
authors: C
authors: Hernández
authors: Marie-Dominique
authors: MD
authors: Hardy-Dessources
mesh_terms: D059787:Acute Pain / Q000097:blood / Q000209:etiology / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications / Q000276:immunology*; D001457:Anion Exchange Protein 1, Erythrocyte / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000473:pathology; D004903:Erythrocyte Aggregation; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D007511:Ischemia / Q000097:blood / Q000209:etiology / Q000276:immunology; D008297:Male; D018384:Oxidative Stress; D055815:Young Adult
chemical_list: D001457:Anion Exchange Protein 1, Erythrocyte; D001323:Autoantibodies; C454201:SLC4A1 protein, human