title: Novel use of topical dapsone 5% gel for erythema elevatum diutinum: safer and effective.
abstract: We present a case of an otherwise healthy 81-year-old gentleman with multiple asymptomatic, erythematous, indurated papules and plaques, ranging in size from 0.5 to 1.5 cm, involving the dorsal, lateral, and palmar surfaces of the fingers bilaterally. A clinical suspicion of erythema elevatum diutinum (EED) led to initial treatment with topical dapsone 5% gel (ACZONE; Allergan Inc, Irvine, CA). Lesional biopsy demonstrated a dense perivascular infiltration of polymorphonuclear leukocytes and chronic inflammatory cells with perivascular fibrin deposition. Focal neutrophilic infiltration of superficial dermal blood vessel walls was present, suggesting a leukocytoclastic vasculitis. Stains for bacteria and fungi were negative. Clinicopathologic findings were consistent with EED, and in the interim, improvement with topical dapsone 5% gel was noted. Addition of oral dapsone led to complete resolution of the lesions. We present this case to illustrate the subtle, indolent clinical presentation of EED and demonstrate the uncomplicated use of topical dapsone 5% gel for rapid improvement and subsequent successful treatment of localized disease.
authors: Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. gfrielin@bidmc.harvard.edu
authors: Gretchen W
authors: GW
authors: Frieling
authors: Noelle L
authors: NL
authors: Williams
authors: Scott J M
authors: SJ
authors: Lim
authors: Seth I
authors: SI
authors: Rosenthal
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003622:Dapsone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D008297:Male; D020556:Neutrophil Infiltration; D016896:Treatment Outcome; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000890:Anti-Infective Agents; D005782:Gels; D003622:Dapsone