title: Cytokine gene polymorphism and graft-versus-host disease: a survey in Iranian bone marrow transplanted patients.
abstract: Graft versus host disease (GVHD) is a major complication of bone marrow transplantation (BMT). Numerous studies have shown the potential role of cytokine genotypes in the occurrence of GVHD. In this retrospective, case-control study we aimed to investigate the association between 13 cytokine genes and acute GVHD (aGVHD) after HLA-identical sibling BMT in 91 Iranian subjects. Negative association was found between aGVHD and donor IL-10/GCC haplotype or donor IL-4Ra-A allele in the population study. When compared within the leukemia subgroup, we observed positive association between recipient IL-1α -889/C allele and aGVHD. Also there were negative association between recipient IL-10/CAA haplotype and donor IL-4Ra/A allele and development of aGVHD. Among the different genotypes only donor IL-4Ra and donor IL-12 showed significant association. We conclude that several cytokine polymorphisms are positively and negatively associated with aGVHD in Iranian HLA matched siblings, of which IL-4Ra and IL-12 may play important roles.
authors: Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Poursina Ave, 16 Azar St. Keshavarz BLVD, 1417613151, Tehran, Iran. nooridaloii@sina.tums.ac.ir
authors: Mohammad Reza
authors: MR
authors: Noori-Daloii
authors: Nazanin
authors: N
authors: Jalilian
authors: Pantea
authors: P
authors: Izadi
authors: Maryam
authors: M
authors: Sobhani
authors: Zeinab
authors: Z
authors: Rabii-Gilani
authors: Mir Saeed
authors: MS
authors: Yekaninejad
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D006086:Graft vs Host Disease / Q000453:epidemiology* / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D053582:Interleukin-1alpha / Q000235:genetics*; D007492:Iran / Q000453:epidemiology; D016015:Logistic Models; D011110:Polymorphism, Genetic / Q000235:genetics*; D019948:Receptors, Interleukin-4 / Q000235:genetics; D012189:Retrospective Studies
chemical_list: D053582:Interleukin-1alpha; D019948:Receptors, Interleukin-4; D016753:Interleukin-10
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