title: Analysis of the application of MMP-9 inhibitor in skin melanoma: experimental study.
abstract: Experiment on C57Bl/6 mice with modeled skin melanoma showed that selective inhibition of matrix metalloproteinase-9 increased lifetime and reduced the number of PCNA(+) tumor cells and intensity of neoangiogenesis. Inhibition of matrix metalloproteinase-9 prevented tumor necrosis. The results suggest that matrix metalloproteinase-9 is involved not only in the regulation of extracellular matrix degradation, but also in the processes of cell proliferation and neoangiogenesis in skin melanoma. Therefore, this enzyme can be considered as a potential therapeutic target.
authors: Prof. V. V. Ivanov Department of Pathological Physiology with the Course of Clinical Pathophysiology, Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Russia.
authors: M B
authors: MB
authors: Aksenenko
authors: T G
authors: TG
authors: Ruksha
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D061965:Matrix Metalloproteinase Inhibitors / Q000627:therapeutic use*; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D011897:Random Allocation
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D018809:Proliferating Cell Nuclear Antigen; D020780:Matrix Metalloproteinase 9