title: Design, synthesis and structure activity relationships of spirocyclic compounds as potent CCR1 antagonists.
abstract: A series of CCR1 antagonists based upon spirocyclic compounds 1b and 2b were synthesised in which substituted aniline moiety was replaced with substituted benzamides. In vitro data revealed that CCR1 potency could be retained in such compounds.
authors: Department of Medicinal Chemistry, RIA Innovative Medicines, AstraZeneca R&D, Pepparedsleden 1, SE-431 83 Mölndal, Sweden. nafizal.hossain@astrazeneca.com
authors: Nafizal
authors: N
authors: Hossain
authors: Svetlana
authors: S
authors: Ivanova
authors: Jonas
authors: J
authors: Bergare
authors: Marguérite
authors: M
authors: Mensonides-Harsema
authors: Martin E
authors: ME
authors: Cooper
mesh_terms: D015195:Drug Design; D006801:Humans; D054389:Receptors, CCR1 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D054389:Receptors, CCR1; D013141:Spiro Compounds