title: Treatment of periodontitis as a manifestation of neutropenia with or without systemic antibiotics: a systematic review.
abstract: The purposes of this paper were to systematically review the clinical presentations and management of periodontitis patients with neutropenia and present a patient with severe autoimmune neutropenia. Twenty-four case reports describing a total of 33 patients were identified. The reported signs and symptoms occurred in either a generalized or localized pattern. Improvements in periodontal condition were observed in 86% of patients who were administered adjuvant systemic antibiotics compared to 47% of patients who were not given supplemental therapy. Granulocyte-colony stimulating factor was administered to 67% of the neutropenic patients, and both improvement and progression of the hematological condition were monitored. Scaling and root planing, in combination with systemic antibiotics to supplement therapy for the underlying disease, have been successful in most cases.
authors: Department of Periodontology, Cariology, and Endodontology, School of Dentistry, University of Basel, Basel, Switzerland.
authors: Julia C
authors: JC
authors: Schmidt
authors: Clemens
authors: C
authors: Walter
authors: Johannes R
authors: JR
authors: Rischewski
authors: Roland
authors: R
authors: Weiger
mesh_terms: D000293:Adolescent; D016301:Alveolar Bone Loss / Q000188:drug therapy / Q000209:etiology; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000175:diagnosis*; D012534:Dental Scaling / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000188:drug therapy / Q000209:etiology; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D008795:Metronidazole / Q000627:therapeutic use; D009503:Neutropenia / Q000276:immunology*; D009910:Oral Hygiene; D010518:Periodontitis / Q000188:drug therapy* / Q000209:etiology; D016745:Root Planing / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001323:Autoantibodies; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D008795:Metronidazole; D016179:Granulocyte Colony-Stimulating Factor; D019980:Amoxicillin-Potassium Clavulanate Combination