title: Cu(OTf)2-catalyzed asymmetric Friedel-Crafts alkylation reaction of indoles with arylidene malonates using bis(sulfonamide)-diamine ligands.
abstract: A highly efficient Cu-catalyzed asymmetric Friedel-Crafts alkylation reaction of indoles with arylidene malonates using simple, stable, and easily prepared bis-sulfonamide diamine ligands was developed. The desired products were obtained in up to 99% yield with 96% ee.
authors: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
authors: Jing
authors: J
authors: Wu
authors: Dongping
authors: D
authors: Wang
authors: Fan
authors: F
authors: Wu
authors: Boshun
authors: B
authors: Wan
mesh_terms: D000478:Alkylation; D002384:Catalysis; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D008024:Ligands; D008314:Malonates / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003959:Diamines; D007211:Indoles; D008024:Ligands; D008314:Malonates; D008698:Mesylates; D013449:Sulfonamides; C012077:trifluoromethanesulfonic acid