title: Nanotechnology in diagnostics and therapeutics for gastrointestinal disorders.
abstract: This review describes the state of the art in nanoparticle and nanodevice applications for medical diagnosis and disease treatment. Nanodevices, such as cantilevers, have been integrated into high-sensitivity disease marker diagnostic detectors and devices, are stable over long periods of time, and display reliable performance properties. Nanotechnology strategies have been applied to therapeutic purposes as well. For example, nanoparticle-based delivery systems have been developed to protect drugs from degradation, thereby reducing the required dose and dose frequency, improving patient comfort and convenience during treatment, and reducing treatment expenses. The main objectives for integrating nanotechnologies into diagnostic and therapeutic applications in the context of intestinal diseases are reviewed.
authors: Department of Biology, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USA. Electronic address: hlaroui@gsu.edu.
authors: Hamed
authors: H
authors: Laroui
authors: Poonam
authors: P
authors: Rakhya
authors: Bo
authors: B
authors: Xiao
authors: Emilie
authors: E
authors: Viennois
authors: Didier
authors: D
authors: Merlin
mesh_terms: D015179:Colorectal Neoplasms / Q000175:diagnosis; D050091:Dendrimers / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy; D008081:Liposomes / Q000627:therapeutic use; D050997:Nanomedicine; D057145:Nanoshells / Q000627:therapeutic use; D049329:Nanostructures / Q000627:therapeutic use*; D053770:Nanowires; D045663:Quantum Dots
chemical_list: D050091:Dendrimers; D008081:Liposomes
keywords: Diagnostics; Gastroenterology; Nanotechnology; Therapeutics
references: Trends Biotechnol. 1998 Jul;16(7):307-21
references: 9675915
references: Anal Bioanal Chem. 2006 Jan;384(2):322-35
references: 16132132
references: PLoS One. 2012;7(8):e43100
references: 22937015
references: Mol Pharm. 2013 Mar 4;10(3):857-66
references: 23110457
references: Nanomedicine (Lond). 2012 Sep;7(9):1425-42
references: 22994959
references: Korean J Gastroenterol. 2007 May;49(5):271-9
references: 17525514
references: Gastroenterology. 2010 Mar;138(3):843-53.e1-2
references: 19909746
references: Adv Drug Deliv Rev. 2005 Dec 14;57(15):2106-29
references: 16305813
references: Biomaterials. 2007 Nov;28(31):4717-32
references: 17686516
references: Int J Nanomedicine. 2012;7:511-26
references: 22334781
references: Am J Physiol Gastrointest Liver Physiol. 2011 Mar;300(3):G371-83
references: 21148398
references: ACS Nano. 2011 Mar 22;5(3):1685-92
references: 21322534
references: Acc Chem Res. 2002 Dec;35(12):1096-104
references: 12484798
references: J Hazard Mater. 2012 Apr 15;211-212:427-35
references: 22226052
references: Biomacromolecules. 2007 Dec;8(12):3879-85
references: 18039001
references: N Engl J Med. 2003 Jun 19;348(25):2491-9
references: 12815134
references: Science. 2003 May 30;300(5624):1434-6
references: 12775841
references: Chem Rec. 2010 Dec;10(6):366-76
references: 20836092
references: Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):586-91
references: 21220299
references: Langmuir. 2010 May 18;26(10):6883-6
references: 20405859
references: Phys Rev Lett. 1985 Nov 25;55(22):2455-2458
references: 10032149
references: J Natl Cancer Inst. 2004 May 5;96(9):703-8
references: 15126607
references: Nanoscale. 2013 Feb 21;5(4):1678-86
references: 23340972
references: Small. 2011 Jul 18;7(14):2032-6
references: 21656907
references: ACS Nano. 2012 Apr 24;6(4):3346-55
references: 22463104
references: Biochem Soc Trans. 2007 Feb;35(Pt 1):61-7
references: 17233602
references: Trends Biotechnol. 2007 Apr;25(4):145-52
references: 17316852
references: J Biomed Mater Res A. 2012 Aug;100(8):1954-62
references: 22528961
references: Mol Cancer Ther. 2003 May;2(5):489-96
references: 12748311
references: Neoplasia. 2005 Nov;7(11):984-91
references: 16331884
references: Int J Nanomedicine. 2011;6:2963-79
references: 22162655
references: Toxicology. 2011 Apr 11;282(3):94-103
references: 21291946
references: Nanoscale Res Lett. 2012 Feb 21;7(1):144
references: 22348683
references: Int J Nanomedicine. 2012;7:4391-408
references: 22927757
references: J Nucl Med. 2008 Jun;49 Suppl 2:113S-28S
references: 18523069
references: Nat Biotechnol. 2005 Nov;23(11):1418-23
references: 16244656
references: J Am Chem Soc. 2003 Aug 27;125(34):10192-3
references: 12926940
references: ACS Nano. 2011 Jan 25;5(1):413-23
references: 21138323
references: J Am Chem Soc. 2004 May 19;126(19):5932-3
references: 15137735
references: Analyst. 2013 Mar 21;138(6):1794-802
references: 23373062
references: J Phys Chem C Nanomater Interfaces. 2011 Aug 18;115(32):15933-15937
references: 21927639
references: Neuropathol Appl Neurobiol. 2004 Oct;30(5):456-71
references: 15488022
references: Biomaterials. 2008 Aug-Sep;29(24-25):3477-96
references: 18499247
references: Anal Chem. 2013 Jan 15;85(2):1058-64
references: 23215018
references: Biomaterials. 2012 Feb;33(5):1238-44
references: 22078811
references: Dis Markers. 2002;18(4):167-74
references: 12590170
references: Methods Enzymol. 2012;509:101-25
references: 22568903
references: Nat Rev Cancer. 2003 Apr;3(4):243-52
references: 12671663
references: Int J Nanomedicine. 2012;7:1749-59
references: 22619525
references: Nat Rev Cancer. 2005 Mar;5(3):161-71
references: 15738981
references: Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):4995-5000
references: 12704236
references: J Am Chem Soc. 2005 Aug 3;127(30):10676-85
references: 16045355
references: Int J Nanomedicine. 2012;7:2833-42
references: 22745546
references: Bioorg Med Chem. 2010 Feb 15;18(4):1599-609
references: 20097081
references: J Am Chem Soc. 2004 Oct 20;126(41):13216-7
references: 15479063
references: Anal Bioanal Chem. 2006 Jun;385(3):452-68
references: 16568294
references: Biomaterials. 2012 Nov;33(33):8486-94
references: 22906608
references: Cancer Res. 2007 Sep 1;67(17):8156-63
references: 17804728
references: Biomaterials. 2011 Feb;32(4):1218-28
references: 20970849
references: Bioconjug Chem. 1996 Nov-Dec;7(6):703-14
references: 8950489
references: Inflamm Bowel Dis. 2011 May;17(5):1163-76
references: 20872832
references: Biomaterials. 2012 Oct;33(28):6793-807
references: 22721724
references: Nat Biotechnol. 1999 Apr;17(4):375-8
references: 10207887
references: Trends Biotechnol. 1997 Jun;15(6):217-24
references: 9183864
references: Anal Chim Acta. 2012 Oct 24;749:1-15
references: 23036462
references: Biomaterials. 2012 May;33(15):4002-9
references: 22377325
references: Macromolecules. 1998 Jul 28;31(15):5084-93
references: 9680449
references: Nanotechnol Sci Appl. 2008 Sep 19;1:17-32
references: 24198458
references: Nat Nanotechnol. 2010 Feb;5(2):138-42
references: 20010825
references: Nat Biotechnol. 2005 Oct;23(10):1294-301
references: 16170313
references: Nat Biotechnol. 2004 Aug;22(8):969-76
references: 15258594
references: J Ocul Pharmacol Ther. 2013 Mar;29(2):151-65
references: 23410062
references: Angew Chem Int Ed Engl. 2009;48(30):5418-29
references: 19562807
references: Cancer Res. 2003 Dec 1;63(23):8122-5
references: 14678964