title: Neuropsychiatric side effects of cyclobenzaprine.
abstract: Cyclobenzaprine is commonly used as a muscle relaxant and analgesic. Given its tricyclic properties, serotonin syndrome is a potential side effect of this drug. We report an unusual case of a patient who experienced symptoms of delirium and hyperkinetic movement disorders shortly after initiating treatment with cyclobenzaprine and oxycodone. Symptoms resolved within 48 h of discontinuing cyclobenzaprine. This case serves to remind clinicians to monitor for serotonin syndrome when initiating cyclobenzaprine, and when adding opiate or antidepressant medications to the regimen.
authors: Department of Neurology, University of Utah, Salt Lake City, Utah, USA. david.shprecher@hsc.utah.edu
authors: David
authors: D
authors: Shprecher
authors: Colgan T
authors: CT
authors: Sloan
authors: Benson
authors: B
authors: Sederholm
mesh_terms: D000639:Amitriptyline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003693:Delirium / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology*; D009125:Muscle Relaxants, Central / Q000009:adverse effects* / Q000627:therapeutic use; D010098:Oxycodone / Q000009:adverse effects*; D010146:Pain / Q000188:drug therapy; D020230:Serotonin Syndrome / Q000139:chemically induced*
chemical_list: D000928:Antidepressive Agents; D009125:Muscle Relaxants, Central; D000639:Amitriptyline; C004704:cyclobenzaprine; D010098:Oxycodone
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