title: Changes in prostaglandin E2 levels in seminal plasma during ejaculation and the effect of exogenous prostaglandin E2 on semen volume in the dog.
abstract: In healthy male dogs, peripheral plasma testosterone (T), prostaglandin E2 (PGE2) and seminal plasma PGE2 levels were measured before, during and after ejaculation, and semen quality was examined after oral administration of PGE2. Plasma T and PGE2 levels did not change during these periods, but the seminal plasma PGE2 level of combined the first and second fractions was significantly higher than those at 0-5 and 5-10 min after the start of ejaculation of the third fraction. Semen volume but not quality increased after PGE2 administration. In conclusion, large amounts of PGE2 are released from the prostate gland during the early part of ejaculation, and PGE2 plays an essential role in secretion of seminal plasma.
authors: Laboratory of Reproduction, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan.
authors: Masanori
authors: M
authors: Kobayashi
authors: Tatsuya
authors: T
authors: Hori
authors: Eiichi
authors: E
authors: Kawakami
mesh_terms: D000818:Animals; D015232:Dinoprostone / Q000032:analysis* / Q000378:metabolism / Q000494:pharmacology; D004285:Dogs; D004542:Ejaculation / Q000502:physiology*; D008297:Male; D011467:Prostate / Q000378:metabolism; D012661:Semen / Q000737:chemistry* / Q000187:drug effects; D055101:Semen Analysis / Q000662:veterinary; D013739:Testosterone / Q000032:analysis
chemical_list: D013739:Testosterone; D015232:Dinoprostone