title: Hypertrophic Cardiomyopathy After a Single Dose of Dexamethasone in a Preterm Infant.
abstract: Dexamethasone is widely used in preterm infants with severe pulmonary disease. Hypertrophic cardiomyopathy (HCM) is a transient side effect observed after multiple doses of dexamethasone. We report a preterm infant with myocardial hypertrophy after a single dose of dexamethasone (0.5 mg/kg) used to treat laryngeal edema secondary to prolonged intubation. A benign course was observed without left ventricular outflow tract obstruction and with recovery within 4 weeks. Myocardial effects of dexamethasone may be independent of dose and duration of treatment. The risk/benefit ratio must be carefully considered before using even a single dose of dexamethasone in preterm infants.
authors: Department of Neonatology, Etlik Zübeyde Hanım Women's Health Teaching and Research Hospital, Ankara, Turkey.
authors: Yusuf
authors: Y
authors: Kale
authors: Department of Neonatology, Etlik Zübeyde Hanım Women's Health Teaching and Research Hospital, Ankara, Turkey. Electronic address: drozgegenc@yahoo.com.tr.
authors: Ozge
authors: O
authors: Aydemir
authors: Department of Pediatric Cardiology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.
authors: Ozben
authors: O
authors: Ceylan
authors: Department of Neonatology, Etlik Zübeyde Hanım Women's Health Teaching and Research Hospital, Ankara, Turkey.
authors: Ahmet Yagmur
authors: AY
authors: Bas
authors: Department of Neonatology, Etlik Zübeyde Hanım Women's Health Teaching and Research Hospital, Ankara, Turkey.
authors: Nihal
authors: N
authors: Demirel
mesh_terms: D002312:Cardiomyopathy, Hypertrophic / Q000139:chemically induced* / Q000175:diagnosis; D003907:Dexamethasone / Q000009:adverse effects*; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008171:Lung Diseases / Q000188:drug therapy
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone
keywords: dexamethasone; hypertrophic cardiomyopathy; neonate; preterm infant