title: Association between the interleukin 6 genotype at position -174 and atopic dermatitis.
abstract: BACKGROUND
  Atopic dermatitis (AD) is a chronic skin disorder of unknown origin that usually manifests for the first time in early infancy. Different types of genetic predisposition and environmental factors seem to be associated with the disease.
  
  
  METHODS
  This study was performed to evaluate the frequency of alleles, genotypes, and haplotypes of interleukin (IL) 6 single-nucleotide polymorphisms (SNPs) at positions -174 and nt565 in 89 Iranian children with AD and 139 healthy controls.
  
  
  RESULTS
  The G allele was significantly more frequent at position -174 in IL6 in atopic patients than in the healthy controls (P < .001; OR, 2.82). Genotype GG was found at the same position in 71% of the patients; this frequency was significantly higher than the frequency of 30% recorded in the controls (P < .001; OR, 5.60). The GG haplotype of IL6 (-174, nt565) was significantly more frequent in the atopic patients than in the healthy controls (P < .001; OR, 2.99).
  
  
  CONCLUSIONS
  A significant increase in the frequency of the G allele and GG genotype at position -174 of IL6 was found in patients with AD, thus suggesting that production of this cytokine is greater in atopic patients.
authors: Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: M
authors: M
authors: Gharagozlou
authors: E
authors: E
authors: Farhadi
authors: M
authors: M
authors: Khaledi
authors: N
authors: N
authors: Behniafard
authors: S
authors: S
authors: Sotoudeh
authors: R
authors: R
authors: Salari
authors: B
authors: B
authors: Darabi
authors: S M
authors: SM
authors: Fathi
authors: M
authors: M
authors: Mahmoudi
authors: A
authors: A
authors: Aghamohammadi
authors: A A
authors: AA
authors: Amirzargar
authors: N
authors: N
authors: Rezaei
mesh_terms: D000293:Adolescent; D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002897:Chromosomes, Human, Pair 7; D003876:Dermatitis, Atopic / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006239:Haplotypes; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007223:Infant; D015850:Interleukin-6 / Q000235:genetics* / Q000276:immunology; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide
chemical_list: D015850:Interleukin-6; D007073:Immunoglobulin E