title: [Values of magnetic resonance spectrum imaging in the diagnosis of hepatic fibrosis of rats].
abstract: OBJECTIVE
  To explore the values of magnetic resonance spectrum (MRS) in early diagnosis, quantization analysis and staging of hepatic fibrosis.
  
  
  METHODS
  A rat model of hepatic fibrosis was established by the method of carbon tetra carbon (CCl4). A total of 47 SD rats were divided into model (n = 40) and control (n = 7) groups. 1H-MRS was performed. The model rats of hepatic fibrosis were grouped according to their pathological stages. The ratio of peak height and peak area of metabolites and lipid (Cho/Lip, Glx/Lip, Lac/Lip and Cr/Lip) were calculated and compared respectively.
  
  
  RESULTS
  The ratios of peak height of metabolites and lipid were as follows: ratio of Cho and Lip: significant differences existed between control and grades 3 and 4 model groups (P < 0.05); ratio of Glx and Lip: significant differences existed between control and grades 2, 3 and 4 model groups (P < 0.05); ratio of Cr and Lip: significant differences existed between control and grade 3 model groups (P < 0.05). The peak area ratio of main metabolites and lipid of liver were as follows: ratio of Cho and Lip: significant differences existed between control and grade 4 model groups (P < 0.05); ratio of Glx and Lip: significant differences existed between control and other groups (P < 0.05); ratio of Cr and Lip: significant differences existed between control and grade 4 model groups (P < 0.05); ratio of Lac and Lip: no significant differences existed between these groups (P > 0.05).
  
  
  CONCLUSIONS
  The ratios of peak height and peak area of Cho/Lip, Glx/Lip and Cr/Lip are important for the staging of hepatic fibrosis.
authors: Department of Radiology, Second Affiliated Hospital, Soochow University, Suzhou, China.
authors: Guo-hua
authors: GH
authors: Fan
authors: Jian-ping
authors: JP
authors: Gong
authors: Jun-kang
authors: JK
authors: Shen
authors: Cai-yuan
authors: CY
authors: Zhang
authors: Xiao-qiu
authors: XQ
authors: Xu
authors: Liang
authors: L
authors: Xu
authors: Ze-yang
authors: ZY
authors: Yu
authors: Wei
authors: W
authors: Zhang
authors: Hao-rong
authors: HR
authors: Wu
mesh_terms: D000818:Animals; D008106:Liver Cirrhosis, Experimental / Q000175:diagnosis* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley