title: Higher serum uric acid is associated with higher bone mass, lower bone turnover, and lower prevalence of vertebral fracture in healthy postmenopausal women.
abstract: Higher serum uric acid (UA) was associated with higher bone mass, lower bone turnover, and lower prevalence of vertebral fracture in postmenopausal women. Furthermore, UA suppressed osteoclastogenesis and decreased production of reactive oxygen species in osteoclast precursors, indicating UA may have beneficial effects on bone metabolism as an antioxidant.
  
  
  BACKGROUND
  UA is known to play a physiological role as an antioxidant, and oxidative stress has detrimental effects on bone metabolism. In the present study, we investigated the association of serum UA level with the osteoporosis-related phenotypes and its direct effect on bone-resorbing osteoclasts using in vitro systems.
  
  
  METHODS
  This is a large cross-sectional study, including 7,502 healthy postmenopausal women. Bone mineral density (BMD) and serum UA concentrations were obtained from all subjects. Data on bone turnover markers and lateral thoracolumbar radiographs were available for 1,023 and 6,918 subjects, respectively. An in vitro study investigated osteoclastogenesis and reactive oxygen species (ROS) levels according to UA treatment.
  
  
  RESULTS
  After adjusting for multiple confounders, serum UA levels were positively associated with BMD at all sites (all p < 0.001). Compared with the participants in the highest UA quartile, the odds for osteoporosis were 40 % higher in those in the lowest quartile. The serum UA levels were inversely related to both serum C-terminal telopeptide of type I collagen and osteocalcin levels (p < 0.001 and p = 0.004, respectively). Consistently, subjects with vertebral fracture had lower serum UA levels, compared with those without it (p = 0.009). An in vitro study showed that UA decreased osteoclastogenesis in a dose-dependent manner and reduced the production of ROS in osteoclast precursors.
  
  
  CONCLUSIONS
  These results provide epidemiological and experimental evidence that serum UA may have a beneficial effect on bone metabolism as an antioxidant in postmenopausal women.
authors: Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap2-Dong, Songpa-Gu, Seoul, 138-736, Republic of Korea.
authors: S H
authors: SH
authors: Ahn
authors: S H
authors: SH
authors: Lee
authors: B-J
authors: BJ
authors: Kim
authors: K-H
authors: KH
authors: Lim
authors: S J
authors: SJ
authors: Bae
authors: E H
authors: EH
authors: Kim
authors: H-K
authors: HK
authors: Kim
authors: J W
authors: JW
authors: Choe
authors: J-M
authors: JM
authors: Koh
authors: G S
authors: GS
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000886:Anthropometry / Q000379:methods; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D015519:Bone Density / Q000502:physiology*; D001854:Bone Marrow Cells / Q000187:drug effects; D016723:Bone Remodeling / Q000502:physiology*; D002478:Cells, Cultured; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008019:Life Style; D051379:Mice; D008875:Middle Aged; D010010:Osteoclasts / Q000187:drug effects; D058866:Osteoporotic Fractures / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D017698:Postmenopause / Q000097:blood / Q000502:physiology; D015995:Prevalence; D017382:Reactive Oxygen Species / Q000378:metabolism; D056910:Republic of Korea / Q000453:epidemiology; D016103:Spinal Fractures / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D014527:Uric Acid / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D014527:Uric Acid
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