title: Oral administration of the CCR5 inhibitor, maraviroc, blocks HIV ex vivo infection of Langerhans cells within the epithelium.
authors: Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
authors: Takamitsu
authors: T
authors: Matsuzawa
authors: Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan. Electronic address: tkawa@yamanashi.ac.jp.
authors: Tatsuyoshi
authors: T
authors: Kawamura
authors: Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
authors: Youichi
authors: Y
authors: Ogawa
authors: Department of Pharmacy, Nagoya Medical Center, Aichi, Japan.
authors: Masaaki
authors: M
authors: Takahashi
authors: Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
authors: Rui
authors: R
authors: Aoki
authors: Department of Microbiology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
authors: Kohji
authors: K
authors: Moriishi
authors: Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, Japan.
authors: Yoshio
authors: Y
authors: Koyanagi
authors: AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan.
authors: Hiroyuki
authors: H
authors: Gatanaga
authors: Oregon Medical Research Center, Portland, Oregon, USA.
authors: Andrew
authors: A
authors: Blauvelt
authors: Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
authors: Shinji
authors: S
authors: Shimada
mesh_terms: D000284:Administration, Oral; D000328:Adult; D065100:CCR5 Receptor Antagonists; D002853:Chromatography, Liquid; D018920:Coculture Techniques; D003510:Cyclohexanes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004334:Drug Administration Schedule; D004848:Epithelium / Q000187:drug effects*; D023581:HIV Fusion Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D007801:Langerhans Cells / Q000187:drug effects*; D008297:Male; D000077592:Maraviroc; D013058:Mass Spectrometry; D019713:Receptors, CCR5; D013997:Time Factors; D014230:Triazoles / Q000008:administration & dosage* / Q000493:pharmacokinetics; D055815:Young Adult
chemical_list: D065100:CCR5 Receptor Antagonists; C584933:CCR5 protein, human; D003510:Cyclohexanes; D023581:HIV Fusion Inhibitors; D019713:Receptors, CCR5; D014230:Triazoles; D000077592:Maraviroc