title: Aromatase variants modify risk for Alzheimer's disease in a multiethnic female cohort.
abstract: OBJECTIVE
  Few studies of gene variants that affect estrogen activity investigate their association with risk for Alzheimer's disease (AD) in women of different ethnicities. We investigated the influence of CYP19 polymorphisms on risk for AD in a multiethnic cohort of women, with individual ethnicity assessed by genetic population ancestry informative markers (AIMs) as well as by self-identified ethnicity.
  
  
  METHODS
  Among 1,686 women participating in the Washington Heights Inwood Columbia Aging Project, association with risk for AD was assessed for 41 single nucleotide polymorphisms (SNPs) on the CYP19 gene using multivariable logistic regression, adjusting for age, presence of an APOE ε4 allele, years of education, and body mass index.
  
  
  RESULTS
  Risk for AD was associated with 6 SNPs in women of predominantly Caucasian AIMs-defined ancestry. Of these, 2 were also associated with decreased risk of AD in women of admixed/Hispanic AIMs ancestry. Two separate SNPs were found to be protective in women of predominantly African AIMs-based ancestry.
  
  
  CONCLUSIONS
  CYP19 polymorphisms affect risk for AD in women, and risk alleles vary by AIMs-defined ancestry. These effects are possibly due to linkage disequilibrium patterns or differences in the prevalence of comorbid risk factors mediating the SNP effect on risk for AD by group.
authors: Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, N.Y., USA. scj2110@columbia.edu
authors: S C
authors: SC
authors: Janicki
authors: N
authors: N
authors: Park
authors: R
authors: R
authors: Cheng
authors: N
authors: N
authors: Schupf
authors: L N
authors: LN
authors: Clark
authors: J H
authors: JH
authors: Lee
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D001141:Aromatase / Q000235:genetics*; D015331:Cohort Studies; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005006:Ethnicity; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012306:Risk
chemical_list: D001057:Apolipoproteins E; D004247:DNA; D001141:Aromatase
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