title: Changes of choroidal thickness, intraocular pressure and other optical coherence tomographic parameters after haemodialysis.
abstract: BACKGROUND
  The aim was to evaluate changes in choroidal thickness, intraocular pressure (IOP) and other parameters of optical coherence tomography, such as central foveal thickness (CFT), macular volume, peripapillary retinal nerve fibre layer (RNFL) thickness after haemodialysis (HD).
  
  
  METHODS
  Thirty-four eyes of 34 chronic renal failure patients (9 eyes with diabetic patients) who underwent haemodialysis in the Dialysis Unit of Gangneung Asan Hospital were included. CFT, macular volume, peripapillary RNFL and choroidal thickness were measured before and after haemodialysis by optical coherence tomography (OCT, Spectralis; Heidelberg Engineering). Changes in the IOP were evaluated with Goldmann applanation tonometry before and after haemodialysis.
  
  
  RESULTS
  The average choroidal thickness decreased significantly, from 233.1 ± 77.5 μm to 219.1 ± 76.8 μm (paired t-test, p < 0.001). This change correlated with the amount of body weight lost (Pearson's correlation coefficient = 0.348, p = 0.044). The mean IOP decreased from 15.1 ± 2.6 mmHg to 13.9 ± 2.2 mmHg after haemodialysis (paired t-test, p = 0.03). The change in macular volume and the small decrease in CFT (214.0 ± 21.0 μm to 213.8 ± 21.8 μm) were not significant. The measured overall change in RNFL thickness from 93.6 ± 15.5 μm to 94.7 ± 14.6 μm was not significant.
  
  
  CONCLUSIONS
  Haemodialysis can affect various ocular parameters, particularly choroidal thickness and IOP.
authors: Department of Ophthalmology, Gangneung Asan Hospital, University of Ulsan, College of Medicine, Gangwon, South Korea. sungjaeyang@gmail.com
authors: Sung Jae
authors: SJ
authors: Yang
authors: Yang Hee
authors: YH
authors: Han
authors: Gyoung Il
authors: GI
authors: Song
authors: Chung Hyun
authors: CH
authors: Lee
authors: Sae Woon
authors: SW
authors: Sohn
mesh_terms: D000328:Adult; D000368:Aged; D002829:Choroid / Q000473:pathology*; D015862:Choroid Diseases / Q000209:etiology* / Q000473:pathology; D003430:Cross-Sectional Studies; D003930:Diabetic Retinopathy / Q000150:complications / Q000473:pathology; D005260:Female; D005584:Fovea Centralis / Q000473:pathology; D006801:Humans; D007429:Intraocular Pressure; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D006435:Renal Dialysis / Q000009:adverse effects*; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular
keywords: choroidal thickness; haemodialysis; intraocular pressure