title: Serum carboxy-terminal telopeptide of type I collagen (ICTP) as a surrogate marker for vulnerable plaques in atherosclerotic patients: a pilot study.
abstract: Evaluation of atherosclerotic plaques depends on invasive intravascular ultrasonography (IVUS). Carboxy-terminal telopeptide of type I collagen (ICTP) is produced by matrix metalloproteinase (MMP)-dependent digestion of type I collagen. Because vulnerable plaques are rich in type I collagen and MMPs from macrophages, we examined the association between serum ICTP and coronary plaques in patients with coronary disease. We recruited 46 men and 17 women without renal failure or bone diseases affecting serum ICTP, who underwent coronary IVUS. Serum ICTP levels were higher in patients with coronary plaques containing more than 10% necrotic core area than in patients with less than 10% necrotic core area. A positive correlation was found between serum ICTP and necrotic core area. Only serum ICTP was positively correlated with necrotic core area by multivariate analysis (p < 0.05). These results suggest that serum ICTP can be used as a non-invasive marker of vulnerable plaques in atherosclerotic patients.
authors: Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
authors: Shuji
authors: S
authors: Kato
authors: Itsuro
authors: I
authors: Endo
authors: Mitsunori
authors: M
authors: Fujimura
authors: Rika
authors: R
authors: Kuriwaka-Kido
authors: Yuichi
authors: Y
authors: Fujinaka
authors: Ken-Ichi
authors: K
authors: Aihara
authors: Takashi
authors: T
authors: Iwase
authors: Daisuke
authors: D
authors: Inoue
authors: Masashi
authors: M
authors: Akaike
authors: Masahiro
authors: M
authors: Abe
authors: Toshio
authors: T
authors: Matsumoto
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000453:epidemiology / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D024042:Collagen Type I / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology* / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008875:Middle Aged; D009017:Morbidity; D009336:Necrosis; D010455:Peptides / Q000097:blood*; D010865:Pilot Projects; D058226:Plaque, Atherosclerotic / Q000097:blood* / Q000453:epidemiology* / Q000473:pathology; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D020782:Matrix Metalloproteinases