title: [Research progress of Th17 cells and glomerulonephritis].
abstract: T helper (Th) 17 cells are a kind of Th cell subset, and are distinct from the Th1 and Th2 cells and produce interleukin-17A (IL-17A, IL-17). Th17 cells have a mechanism of independent differentiation and developmental regulation. The differentiation and cytokine secretion of Th17 cells are regulated by TGF-β, IL-6, IL-23 and orphan nuclear receptor (RORγt). IL-17A induces pro-inflammatory cytokines and chemokines, mediating neutrophil recruitment. Increasing evidence implicated involvement of Th17 cells in anti-glomerular basement membrane disease, lupus nephritis and pauciimmune glomerulonephritis. In this review, we discussed the discovery of Th17 subset, its properties, its relationship with other Th subsets and involvement of Th17 cells in glomerulonephritis.
authors: Second Xiangya Hospital, Central South University, Changsha, China.
authors: Letian
authors: L
authors: Zhou
authors: Fuyou
authors: F
authors: Liu
mesh_terms: D000818:Animals; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism* / Q000502:physiology; D053760:Interleukin-23 Subunit p19 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000502:physiology; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: C508717:IL17A protein, human; C508840:IL23A protein, human; C508600:IL6 protein, human; D020381:Interleukin-17; D053760:Interleukin-23 Subunit p19; D015850:Interleukin-6; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; C539900:RORC protein, human; D016212:Transforming Growth Factor beta