title: [Changes in pulmonary arteries dilatation reserve during chronic obstructive pulmonary disease model formation].
abstract: Model of chronic obstructive pulmonary disease (COPD) was induced in rats by nitrogen dioxide inhalation for 60 days. The effect of reagents-vasodilators on the isolated pulmonary arteries with a diameter less than 0.5 mm was studied in 15, 30 and 60 days of COPD induction. All vasodilators (beta-adrenoreceptor agonist izopreterenol, nitric oxide donor nitrosorbid, acetylcholine, activator of C-fibers capsaicin, corticosteroid beclometasone) dose-dependently decreased vascular tone of pulmonary arteries isolated from intact rats. On extension nitrogen dioxide exposure pulmonary arteries responded to the impact of all vasodilators by smaller relaxation. Dose-dependence of dilatation reaction disappeared. In the process of COPD model formation functioning of almost all pulmonary arterial wall neurotransmitter systems were broken. This led to decrease in vasodilators influence on vascular tone and could facilitate the development of pulmonary hypertension which is typical of COPD.
authors: N A
authors: NA
authors: Kuzubova
authors: A N
authors: AN
authors: Fedin
authors: E S
authors: ES
authors: Lebedeva
authors: O H
authors: OH
authors: Titova
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage; D000818:Animals; D004106:Dilatation; D004195:Disease Models, Animal; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D009585:Nitrogen Dioxide / Q000633:toxicity; D009924:Organ Culture Techniques; D011651:Pulmonary Artery / Q000187:drug effects* / Q000502:physiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D000109:Acetylcholine; D009585:Nitrogen Dioxide