title: Development of microbial resistant thermosensitive Ag nanocomposite (gelatin) hydrogels via green process.
abstract: In this investigation, an ecofriendly method for the synthesis of silver nanoparticles (AgNPs) using biodegradable gelatin as a stabilizing agent is reported. Here, we prepared thermosensitive silver nanocomposite hydrogels composed of gelatin and N-isopropylacrylamide. In this green process AgNPs were formed from Ag(+) ions and reduced with leaf [Azadirachta indica (neem leaf)] extracts, resulting in a hydrogel network. The Ag(0) nanoparticles affect the hydrogel strength and improved the biological activity (inactivation effect of bacteria) of the biodegradable hydrogels. The resulted hydrogel structure, morphology, thermal, swelling behavior, degradation, and antibacterial properties were systematically investigated. The biodegradable thermosensitive silver nanocomposite hydrogels developed were tested for antibacterial activities. The results indicate that these biodegradable silver nanocomposite hydrogels are suitable potential candidates for antibacterial applications.
authors: Department of Polymer Science & Technology, Synthetic Polymer Laboratory, Sri Krishnadevaraya University, Anantapur, 515003, India.
authors: Bandla
authors: B
authors: Manjula
authors: Kokkarachedu
authors: K
authors: Varaprasad
authors: Rotimi
authors: R
authors: Sadiku
authors: Koduri
authors: K
authors: Ramam
authors: G Venkata Subba
authors: GV
authors: Reddy
authors: Konduru Mohana
authors: KM
authors: Raju
mesh_terms: D000178:Acrylamides / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects; D005780:Gelatin / Q000737:chemistry*; D055772:Green Chemistry Technology / Q000379:methods*; D020100:Hydrogels / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D012834:Silver / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
chemical_list: D000178:Acrylamides; D000900:Anti-Bacterial Agents; D020100:Hydrogels; D012834:Silver; D005780:Gelatin; C067295:N-isopropylacrylamide
keywords: Ag nanoparticles; Azadirachta indica; antibacterial property; biodegradable hydrogels; gelatin