title: Local treatment failure after globe-conserving therapy for choroidal melanoma.
abstract: Local treatment failure after globe-conserving therapy for choroidal melanoma is a surgical complication with significant morbidity to the vision and eye. Few reports in the literature have addressed this complication exclusively. A review of the published literature with reference to local treatment failure in the management of choroidal melanoma was performed to make known the potential differences in failure rates between treatment modalities and methods. A search of the literature regarding local treatment failure was performed to identify relevant studies using combinations of the following keywords on PubMed: uveal melanoma, choroidal melanoma, local recurrence, local failure, endoresection, gamma knife, radiotherapy, helium, iodine, proton, palladium, ruthenium, trans-scleral resection, transpupillary thermotherapy. Further studies were found by searching the text and references of previously identified studies for articles reporting local treatment failure rates in choroidal melanoma. Among the 49 studies identified, the local treatment failure rate ranged from 0% to 55.6%, with follow-up ranging from 10 to 150 months. The two most widely used forms of radiation therapy, iodine-125 and ruthenium-106 brachytherapy, were both associated with a local recurrence rate of 9.6%. The weighted-average of treatment failure in all radiation therapies was 6.15% compared with 18.6% in surgical and 20.8% in laser therapies. Rates of local treatment failure for globe-conserving therapy of choroidal melanoma varied widely between modalities and between centres using similar modalities. Radiation therapy overall resulted in lower local treatment failures compared with surgical or transpupillary thermotherapy.
authors: Department of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, California 90095, USA.
authors: Melinda Y
authors: MY
authors: Chang
authors: Tara A
authors: TA
authors: McCannel
mesh_terms: D001918:Brachytherapy; D002830:Choroid Neoplasms / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced; D008545:Melanoma / Q000175:diagnosis / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D013508:Ophthalmologic Surgical Procedures; D016634:Radiosurgery; D012307:Risk Factors; D017211:Treatment Failure
keywords: Choroid; Ciliary body; Neoplasia; Pathology
references: Int J Radiat Oncol Biol Phys. 2002 Dec 1;54(5):1438-45
references: 12459367
references: Brachytherapy. 2009 Jul-Sep;8(3):290-6
references: 19428308
references: Klin Monbl Augenheilkd. 2003 Dec;220(12):853-60
references: 14704943
references: Surv Ophthalmol. 1997 Nov-Dec;42(3):215-32
references: 9406368
references: Ophthalmology. 2002 Feb;109(2):225-34
references: 11825800
references: Am J Ophthalmol. 2000 Feb;129(2):199-204
references: 10682973
references: Invest Ophthalmol Vis Sci. 2006 Nov;47(11):4666-73
references: 17065472
references: Br J Ophthalmol. 2011 Feb;95(2):166-70
references: 20889528
references: Br J Ophthalmol. 2010 Apr;94(4):460-6
references: 19965818
references: Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1405-11
references: 16029800
references: Am J Ophthalmol. 1999 Jul;128(1):88-93
references: 10482099
references: Ophthalmology. 2012 Mar;119(3):606-10
references: 22226884
references: Am J Ophthalmol. 1999 May;127(5):579-89
references: 10334352
references: Eur J Ophthalmol. 2009 Jul-Aug;19(4):654-60
references: 19551683
references: Retina. 2007 Sep;27(7):908-14
references: 17891016
references: Arch Ophthalmol. 1997 Aug;115(8):1014-8
references: 9258223
references: Ophthalmology. 1999 Aug;106(8):1579-87
references: 10442907
references: Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):e455-62
references: 21708428
references: Br J Ophthalmol. 1996 Feb;80(2):102-8
references: 8814738
references: Ophthalmology. 1993 Oct;100(10):1547-54
references: 8414414
references: Int J Radiat Oncol Biol Phys. 1993 Jul 15;26(4):613-8
references: 8330990
references: Lancet. 1996 May 4;347(9010):1222-5
references: 8622452
references: Arch Ophthalmol. 2006 Feb;124(2):226-38
references: 16476893
references: JAMA. 1994 Jul 13;272(2):158-62
references: 8015133
references: Int J Radiat Oncol Biol Phys. 2005 Sep 1;63(1):101-8
references: 16111577
references: Am J Ophthalmol. 2004 May;137(5):893-900
references: 15126155
references: Arch Ophthalmol. 2006 Dec;124(12):1684-93
references: 17159027
references: Acta Ophthalmol. 2009 Nov;87(7):789-92
references: 18778335
references: Br J Ophthalmol. 2009 Jan;93(1):40-4
references: 18757470
references: Am J Ophthalmol. 1998 Jan;125(1):81-9
references: 9437317
references: Radiother Oncol. 2000 May;55(2):135-44
references: 10799725
references: Ophthalmology. 2011 Feb;118(2):402-7
references: 20813410
references: Radiother Oncol. 2010 Jun;95(3):332-8
references: 20416963
references: Control Clin Trials. 1993 Oct;14(5):362-91
references: 8222668
references: Ophthalmology. 2012 May;119(5):1073-7
references: 22297030
references: Isr Med Assoc J. 2009 May;11(5):280-5
references: 19637505
references: Br J Ophthalmol. 2008 Jun;92(6):741-6
references: 18296506
references: Int J Radiat Oncol Biol Phys. 2006 Jul 1;65(3):780-7
references: 16647221
references: Br J Ophthalmol. 2008 Aug;92(8):1040-5
references: 18653597
references: Graefes Arch Clin Exp Ophthalmol. 2007 Apr;245(4):522-33
references: 17111148
references: Arch Ophthalmol. 1987 Jun;105(6):763-4
references: 3579705
references: Acta Ophthalmol Scand. 2002 Feb;80(1):25-31
references: 11906300
references: Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):385-91
references: 15913907
references: Int J Radiat Oncol Biol Phys. 2001 Mar 15;49(4):1053-9
references: 11240247
references: Am J Ophthalmol. 2006 May;141(5):840-849
references: 16678505
references: Ophthalmology. 2003 Nov;110(11):2235-44
references: 14597535
references: Brachytherapy. 2011 May-Jun;10(3):228-31
references: 20932809
references: Clin Exp Ophthalmol. 2000 Dec;28(6):409-13
references: 11202462
references: Ophthalmology. 1991 Jun;98(6):984-8
references: 1866154
references: Ophthalmology. 2003 Nov;110(11):2207-14; discussion 2215
references: 14597531
references: Brachytherapy. 2011 Jul-Aug;10(4):331-9
references: 21349775
references: Graefes Arch Clin Exp Ophthalmol. 2013 Jan;251(1):285-94
references: 22944897
references: Trans Am Ophthalmol Soc. 2002;100:43-8; discussion 48-9
references: 12545676
references: Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3703-7
references: 16936076
references: Ophthalmology. 2002 Dec;109(12):2197-206
references: 12466159
references: Int J Radiat Oncol Biol Phys. 2001 Sep 1;51(1):138-47
references: 11516863
references: Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):199-205
references: 20675066
references: J Neurosurg. 2002 Dec;97(5 Suppl):635-9
references: 12507111
references: Br J Radiol. 2008 Oct;81(970):784-9
references: 18628320
references: Trans Am Ophthalmol Soc. 2007;105:54-59; discussion 59-60
references: 18427594
references: Am J Ophthalmol. 2003 May;135(5):657-63
references: 12719073
references: Ophthalmology. 2005 Oct;112(10):1777-83
references: 16095708
references: Br J Ophthalmol. 1998 Oct;82(10):1147-53
references: 9924302