title: IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase.
abstract: Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein-protein interactions, 26 enzyme-substrate reactions, 7 translocation events, and 4 activation/ inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from 'NetPath', a repository for signaling pathways. We believe that this will help in the identification of potential therapeutic targets in IL-11-associated disorders.
authors: Institute of Bioinformatics, Bangalore, India.
authors: Lavanya
authors: L
authors: Balakrishnan
authors: Sowmya
authors: S
authors: Soman
authors: Yatish B
authors: YB
authors: Patil
authors: Jayshree
authors: J
authors: Advani
authors: Joji Kurian
authors: JK
authors: Thomas
authors: Dattatraya Venkatesh
authors: DV
authors: Desai
authors: Urmila
authors: U
authors: Kulkarni-Kale
authors: H C
authors: HC
authors: Harsha
authors: T S Keshava
authors: TS
authors: Prasad
authors: Rajesh
authors: R
authors: Raju
authors: Akhilesh
authors: A
authors: Pandey
authors: Eva
authors: E
authors: Dimitriadis
authors: Aditi
authors: A
authors: Chatterjee
mesh_terms: D006801:Humans; D017370:Interleukin-11 / Q000378:metabolism*; D053703:Interleukin-11 Receptor alpha Subunit / Q000378:metabolism*; D020407:Internet; D051188:Knowledge Bases; D015398:Signal Transduction
chemical_list: C508611:IL11 protein, human; C508428:IL11RA protein, human; D017370:Interleukin-11; D053703:Interleukin-11 Receptor alpha Subunit