title: Electro-assisted solid-phase microextraction based on poly(3,4-ethylenedioxythiophen) combined with GC for the quantification of tricyclic antidepressants.
abstract: In this study, a platinum wire coated with poly(3,4-ethylenedioxythiophen) was used as an electro-assisted solid-phase microextraction fiber for the quantification of tricyclic antidepressant drugs in biological samples by coupling to GC employing a flame ionization detector. In this study, an electric field increased the extraction rate and recovery. The fiber used as a solid phase was synthesized by the electropolymerization of 3,4-ethylenedioxythiophen monomers onto a platinum wire. The ability of this fiber to extract imipramine, desipramine, and clomipramine by using the electro-assisted solid-phase microextraction technique was evaluated. The effect of various parameters that influence the extraction efficiency, which include solution temperature, extraction time, stirring rate, ionic strength, time and temperature of desorption, and thickness of the fiber, was optimized. Under optimized conditions, the linear ranges and regression coefficients of calibration curves were in the range of 0.5-250 and 0.990-0.998 ng/mL, respectively. Detection limits were in the range of 0.15-0.45 ng/mL. Finally, this method was applied to the determination of drugs in urine and wastewater samples and recoveries were 4.8-108.9%.
authors: Faculty of Chemistry, Shahid Beheshti University, Tehran, Iran. ss-hosseiny@cc.sbu.ac.ir
authors: Saied Saeed Hosseiny
authors: SS
authors: Davarani
authors: Saeed
authors: S
authors: Nojavan
authors: Roghayeh
authors: R
authors: Asadi
authors: Mohammad Hossein
authors: MH
authors: Banitaba
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000302:isolation & purification* / Q000652:urine*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D002849:Chromatography, Gas / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D011108:Polymers / Q000737:chemistry; D052617:Solid Phase Microextraction / Q000295:instrumentation / Q000379:methods*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011108:Polymers; C121383:poly(3,4-ethylene dioxythiophene)
keywords: Elecro-asissted solid-phase microextraction; Poly(3,4-ethylenedio-xythiophene); Tricyclic antidepressants; Urine; Wastewater