title: Impact of laparoscopic sleeve gastrectomy on upper gastrointestinal symptoms.
abstract: BACKGROUND
  Altered gastric anatomy following laparoscopic sleeve gastrectomy (LSG) is likely to induce upper gastrointestinal (GI) symptoms. Published studies, however, have focused mainly on gastroesophageal reflux disease (GERD). This study aims to evaluate LSG's impact on the prevalence of upper GI symptoms and to assess the effects of time from surgery, weight loss, and proton pump inhibitor (PPI) therapy.
  
  
  METHODS
  The validated Rome III Criteria symptom questionnaire for upper GI symptoms, including quality of life items, has been self-administered to 97 patients who underwent LSG. Symptoms were analyzed either separately or altogether to classify patients in GERD or dyspepsia, subdivided in epigastric pain (EPS) and post-prandial distress (PDS) syndromes.
  
  
  RESULTS
  Before LSG, 52.7% of the patients were asymptomatic, 27.0% had GERD, and 8.1% had dyspepsia (2.7% EPS, 5.4% PDS). After a median follow-up of 13 months, 91.9% of the patients complained of upper GI symptoms, the most prevalent being PDS (59.4 %). GERD prevalence did not differ before and after LSG. The only symptom strongly related to LSG was dysphagia (OR 4.7, 95% CI 1.3-20.4, p = 0.015), which was present in 19.7% of the patients and mainly associated with PDS rather than GERD. GI symptoms, however, did not have a great impact on quality of life. Time from surgery, weight loss after surgery, as well as concomitant PPI, did not influence the symptoms.
  
  
  CONCLUSIONS
  After a median follow-up of 13 months, PDS-like dyspepsia, rather than GERD, was the main complaint, both poorly responding to PPI therapy. A longer follow-up will be necessary to evaluate their future persistency.
authors: Department of Internal Medicine and Medical Specialties, University of Rome "Sapienza", viale del Policlinico 155, 00161, Rome, Italy, mcarabotti@yahoo.it.
authors: Marilia
authors: M
authors: Carabotti
authors: Gianfranco
authors: G
authors: Silecchia
authors: Francesco
authors: F
authors: Greco
authors: Frida
authors: F
authors: Leonetti
authors: Luca
authors: L
authors: Piretta
authors: Marco
authors: M
authors: Rengo
authors: Mario
authors: M
authors: Rizzello
authors: John
authors: J
authors: Osborn
authors: Enrico
authors: E
authors: Corazziari
authors: Carola
authors: C
authors: Severi
mesh_terms: D015746:Abdominal Pain / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D000368:Aged; D004415:Dyspepsia / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D015391:Gastroplasty / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007558:Italy / Q000453:epidemiology; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000453:epidemiology / Q000601:surgery*; D017060:Patient Satisfaction; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D011788:Quality of Life; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D054328:Proton Pump Inhibitors
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