title: A review of tasquinimod in the treatment of advanced prostate cancer.
abstract: Castration resistant prostate cancer remains a major clinical burden and novel therapeutic options are urgently required to improve survival. Tasquinimod is an orally administered quinoline-3-carboxamide with potent antiangiogenic and antitumorigenic action that has shown promise in the treatment of advanced prostate cancers. This review explores both preclinical and clinical findings to date. In summary, tasquinimod has been shown to demonstrate a potent in vitro and in vivo anticancer action and completed early phase clinical trials have demonstrated good drug tolerance and prolonged progression-free survival. Although Phase III clinical trials are on-going, the findings to date highlight the promise of this drug in the treatment of advanced prostate cancer.
authors: Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK.
authors: Stuart Charles
authors: SC
authors: Williamson
authors: Alice Elizabeth
authors: AE
authors: Hartley
authors: Rakesh
authors: R
authors: Heer
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D002986:Clinical Trials as Topic; D055808:Drug Discovery; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D011804:Quinolines / Q000494:pharmacology / Q000627:therapeutic use*; D015363:Quinolones
chemical_list: D020533:Angiogenesis Inhibitors; D011804:Quinolines; D015363:Quinolones; C516109:tasquinimod
keywords: ABR-215050; HDAC4; S100A9; antiangiogenesis; castration resistant prostate cancer; prostate cancer; quinoline-3-carboximide
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