title: Mechanisms of heat shock response in mammals.
abstract: Heat shock (HS) is one of the best-studied exogenous cellular stresses. The cellular response to HS utilizes ancient molecular networks that are based primarily on the action of stress-induced heat shock proteins and HS factors. However, in one way or another, all cellular compartments and metabolic processes are involved in such a response. In this review, we aimed to summarize the experimental data concerning all aspects of the HS response in mammalian cells, such as HS-induced structural and functional alterations of cell membranes, the cytoskeleton and cellular organelles; the associated pathways that result in different modes of cell death and cell cycle arrest; and the effects of HS on transcription, splicing, translation, DNA repair, and replication.
authors: Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia.
authors: Artem K
authors: AK
authors: Velichko
authors: Elena N
authors: EN
authors: Markova
authors: Nadezhda V
authors: NV
authors: Petrova
authors: Sergey V
authors: SV
authors: Razin
authors: Omar L
authors: OL
authors: Kantidze
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D016923:Cell Death / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D004261:DNA Replication; D006360:Heat-Shock Proteins / Q000378:metabolism*; D018869:Heat-Shock Response / Q000502:physiology*; D006801:Humans
chemical_list: D006360:Heat-Shock Proteins
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