title: Soluble lectin-like oxidized LDL receptor-1 (sLOX-1) as a valuable diagnostic marker for rupture of thin-cap fibroatheroma: verification by optical coherence tomography.
abstract: BACKGROUND
  Relationships between plaque morphology on optical coherence tomography (OCT) and biomarker levels in the patients with acute coronary syndrome (ACS) have not been fully investigated.
  
  
  METHODS
  ACS patients (n=128) were prospectively enrolled and their plasma levels of soluble lectin-like oxidized LDL receptor-1 (sLOX-1), high-sensitivity C-reactive protein (hs-CRP), and high-sensitivity troponin T (hs-TnT) were measured. Another set of 20 patients with stable angina pectoris (SAP) without plaque rupture or erosion served as controls. Among 128 ACS patients, 75 patients underwent OCT procedure to evaluate culprit plaque morphology, and were categorized into two groups; ACS with plaque rupture (ruptured ACS; R-ACS, n=54) and ACS without plaque rupture (non-ruptured ACS; N-ACS, n=21).
  
  
  RESULTS
  Levels of sLOX-1 (p<0.001), hs-CRP (p=0.048) and hs-TnT (p<0.001) were significantly higher in R-ACS than SAP. Levels of sLOX-1 were also significantly higher in R-ACS than in N-ACS (p<0.001); whereas levels of hs-CRP (p=0.675), as well as those of hs-TnT (p=0.055), were comparable between R-ACS and N-ACS. Comparison of receiver operating characteristic (ROC) curves among sLOX-1, hs-CRP and hs-TnT to differentiate R-ACS from N-ACS revealed that the area under the curve (AUC) values of sLOX-1, hs-CRP and hs-TnT were 0.782, 0.531 and 0.643, respectively. ROC curves, generated for these biomarkers, to differentiate ACS with thin-cap fibroatheroma (TCFA) from those without demonstrated that the AUC values of sLOX-1, hs-CRP and hs-TnT were 0.718, 0.506 and 0.524, respectively.
  
  
  CONCLUSIONS
  sLOX-1, but not hs-CRP or hs-TnT, can differentiate ACS with plaque rupture from those without, and ACS with TCFA from those without.
authors: Division of Intensive Care Unit, Chiba-Hokusoh Hospital, Nippon Medical School, Chiba, Japan. Electronic address: s5047@nms.ac.jp.
authors: Nobuaki
authors: N
authors: Kobayashi
authors: Masamichi
authors: M
authors: Takano
authors: Noritake
authors: N
authors: Hata
authors: Noriaki
authors: N
authors: Kume
authors: Masanori
authors: M
authors: Yamamoto
authors: Shinya
authors: S
authors: Yokoyama
authors: Takuro
authors: T
authors: Shinada
authors: Kazunori
authors: K
authors: Tomita
authors: Akihiro
authors: A
authors: Shirakabe
authors: Toshiaki
authors: T
authors: Otsuka
authors: Yoshihiko
authors: Y
authors: Seino
authors: Kyoichi
authors: K
authors: Mizuno
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000097:blood* / Q000175:diagnosis*; D011446:Prospective Studies; D012421:Rupture / Q000097:blood / Q000175:diagnosis; D051127:Scavenger Receptors, Class E / Q000097:blood*; D041623:Tomography, Optical Coherence / Q000379:methods*; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E; D020107:Troponin T; D002097:C-Reactive Protein
keywords: Biomarker; High-sensitivity C-reactive protein; High-sensitivity troponin T; Optical coherence tomography; Plaque rupture; Soluble lectin-like oxidized LDL receptor-1