title: A metadata-aware application for remote scoring and exchange of tissue microarray images.
abstract: BACKGROUND
  The use of tissue microarrays (TMA) and advances in digital scanning microscopy has enabled the collection of thousands of tissue images. There is a need for software tools to annotate, query and share this data amongst researchers in different physical locations.
  
  
  RESULTS
  We have developed an open source web-based application for remote scoring of TMA images, which exploits the value of Microsoft Silverlight Deep Zoom to provide a intuitive interface for zooming and panning around digital images. We use and extend existing XML-based standards to ensure that the data collected can be archived and that our system is interoperable with other standards-compliant systems.
  
  
  CONCLUSIONS
  The application has been used for multi-centre scoring of TMA slides composed of tissues from several Phase III breast cancer trials and ten different studies participating in the International Breast Cancer Association Consortium (BCAC). The system has enabled researchers to simultaneously score large collections of TMA and export the standardised data to integrate with pathological and clinical outcome data, thereby facilitating biomarker discovery.
authors: Department of Oncology, University of Cambridge and Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, CB2 0RE, UK.
authors: Lorna
authors: L
authors: Morris
authors: Andrew
authors: A
authors: Tsui
authors: Charles
authors: C
authors: Crichton
authors: Steve
authors: S
authors: Harris
authors: Peter H
authors: PH
authors: Maccallum
authors: William J
authors: WJ
authors: Howat
authors: Jim
authors: J
authors: Davies
authors: James D
authors: JD
authors: Brenton
authors: Carlos
authors: C
authors: Caldas
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D020407:Internet; D012984:Software; D046888:Tissue Array Analysis / Q000379:methods*
references: Nat Med. 1998 Jul;4(7):844-7
references: 9662379
references: Br J Cancer. 2013 Feb 19;108(3):602-12
references: 23329232
references: BMC Med Inform Decis Mak. 2003 May 23;3:5
references: 12769826
references: BMC Med Genomics. 2009 Nov 30;2:66
references: 19948017
references: J Pathol Inform. 2011 Mar 15;2:15
references: 21572508
references: Mod Pathol. 1998 Feb;11(2):155-68
references: 9504686
references: BMC Bioinformatics. 2006 May 17;7:256
references: 16707006
references: Hum Mol Genet. 2011 Aug 15;20(16):3289-303
references: 21596841
references: BMC Bioinformatics. 2008 Apr 25;9 Suppl 4:S4
references: 18460177
references: Nucleic Acids Res. 2008 Jan;36(Database issue):D871-7
references: 17989087
references: PLoS Med. 2010 May 25;7(5):e1000279
references: 20520800
references: Nat Genet. 2001 Dec;29(4):365-71
references: 11726920
references: BMC Bioinformatics. 2005 Sep 01;6:218
references: 16137321