title: Structure of matrix metalloproteinase-3 with a platinum-based inhibitor.
abstract: An X-ray investigation has been performed with the aim of characterizing the binding sites of a platinum-based inhibitor (K[PtCl3(DMSO)]) of matrix metalloproteinase-3 (stromelysin-1). The platinum complex targets His224 in the S1' specificity loop, representing the first step in the selective inhibition process (PDB ID code 4JA1).
authors: Institute of Crystallography, Consiglio Nazionale delle Ricerche, via Amendola 122/o, 70126 Bari, Italy.
authors: Benny Danilo
authors: BD
authors: Belviso
authors: Rocco
authors: R
authors: Caliandro
authors: Dritan
authors: D
authors: Siliqi
authors: Vito
authors: V
authors: Calderone
authors: Fabio
authors: F
authors: Arnesano
authors: Giovanni
authors: G
authors: Natile
mesh_terms: D001665:Binding Sites; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D018360:Crystallography, X-Ray; D019278:Matrix Metalloproteinase 3 / Q000737:chemistry / Q000378:metabolism*; D061965:Matrix Metalloproteinase Inhibitors / Q000737:chemistry* / Q000378:metabolism; D010984:Platinum / Q000737:chemistry*; D011485:Protein Binding; D017434:Protein Structure, Tertiary
chemical_list: D056831:Coordination Complexes; D061965:Matrix Metalloproteinase Inhibitors; D010984:Platinum; D019278:Matrix Metalloproteinase 3