title: Soluble mediators of diabetic macular edema: the diagnostic role of aqueous VEGF and cytokine levels in diabetic macular edema.
abstract: Diabetic macular edema (DME) is a significant cause of vision loss and represents an important clinical and public health problem. It is characterized by breakdown of the blood retinal barrier with fluid accumulation in the sub-retinal and intra-retinal spaces. Although several hypotheses exist for the causes of diabetic macular edema, specific molecular mechanisms remain unclear. Current thinking includes the role of vascular endothelial growth factor (VEGF) and inflammatory cytokines in vascular permeability. We review studies showing a relationship between elevated aqueous VEGF, monocyte chemoattractant protein -1, interleukin 6, or interleukin 8 in association with DME and as predictors of DME. The presence of mediators in both the angiogenesis and inflammatory pathways data suggest a multifactorial model for the development of DME. Further studies targeting individual cytokine activity will be important to our understanding of the pathogenesis and treatment.
authors: Department Of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA. Leah.owen@hsc.utah.edu
authors: Leah A
authors: LA
authors: Owen
authors: M Elizabeth
authors: ME
authors: Hartnett
mesh_terms: D016207:Cytokines / Q000378:metabolism*; D003930:Diabetic Retinopathy / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008269:Macular Edema / Q000150:complications / Q000175:diagnosis*; D012995:Solubility; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D016207:Cytokines; D042461:Vascular Endothelial Growth Factor A
references: Neoplasia. 2010 Jul;12(7):539-49
references: 20651983
references: Arch Ophthalmol. 1985 Dec;103(12):1796-806
references: 2866759
references: Ophthalmology. 2003 Sep;110(9):1690-6
references: 13129863
references: Jpn J Ophthalmol. 2003 Sep-Oct;47(5):469-72
references: 12967862
references: Ophthalmology. 2008 Sep;115(9):1447-9, 1449.e1-10
references: 18662829
references: Ophthalmology. 2007 Apr;114(4):743-50
references: 17398322
references: Ophthalmology. 2012 Apr;119(4):789-801
references: 22330964
references: Ophthalmology. 2002 May;109(5):920-7
references: 11986098
references: Retina. 2006 Mar;26(3):262-9
references: 16508424
references: Blood. 2005 Feb 15;105(4):1405-7
references: 15498848
references: Ophthalmology. 2010 Nov;117(11):2146-51
references: 20855114
references: Invest Ophthalmol Vis Sci. 1998 Jun;39(7):1097-106
references: 9620068
references: Clin Exp Pharmacol Physiol. 2007 Oct;34(10):1016-9
references: 17714088
references: Ophthalmology. 1995 Jan;102(1):7-16
references: 7831044
references: Am J Ophthalmol. 2011 Oct;152(4):686-94
references: 21782151
references: Retina. 2010 Oct;30(9):1412-9
references: 20711086
references: Surv Ophthalmol. 2009 Jan-Feb;54(1):1-32
references: 19171208
references: N Engl J Med. 2012 Mar 29;366(13):1227-39
references: 22455417
references: Ophthalmology. 2009 Jan;116(1):73-9
references: 19118698
references: Diabetes Care. 2010 Nov;33(11):2399-405
references: 20980427
references: Cochrane Database Syst Rev. 2008 Jan 23;(1):CD005656
references: 18254088
references: Curr Eye Res. 2010 Dec;35(12):1116-27
references: 21121809
references: Arch Ophthalmol. 1988 Jan;106(1):100-5
references: 3337683
references: Kidney Int Suppl. 2000 Sep;77:S113-9
references: 10997700
references: Br J Ophthalmol. 2012 Nov;96(11):1426-30
references: 22930681
references: Am J Ophthalmol. 2001 Sep;132(3):425-7
references: 11530068
references: J Cell Sci. 1995 Jun;108 ( Pt 6):2369-79
references: 7673356
references: Am J Ophthalmol. 2002 Jan;133(1):70-7
references: 11755841
references: Diabetologia. 2002 Dec;45(12):1617-34
references: 12488951
references: Ophthalmology. 2009 Jan;116(1):80-6
references: 19118699
references: Am J Ophthalmol. 2009 Dec;148(6):895-901.e1
references: 19837384
references: Am J Ophthalmol. 2005 Oct;140(4):695-702
references: 16226521
references: Invest Ophthalmol Vis Sci. 1999 Oct;40(11):2465-70
references: 10509638
references: Ophthalmology. 2010 Jun;117(6):1064-1077.e35
references: 20427088
references: J Cataract Refract Surg. 2002 Aug;28(8):1355
references: 12160804
references: Ophthalmology. 2007 Dec;114(12):2162-7
references: 17459479