title: Elevated circulating cytotoxic T lymphocyte-associated antigen-4 levels are related to lung function and inflammation in chronic obstructive pulmonary disease.
abstract: Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is involved in immune and inflammation regulation. The present study aimed to investigate the association between CTLA-4 and COPD. Data revealed that serum levels of CTLA-4 were elevated in COPD patients, inversely correlated with lung function and positively correlated with serum C-reactive protein levels in the COPD group. These findings suggest that CTLA-4 may play a role in COPD.
authors: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China.
authors: Yongchun
authors: Y
authors: Shen
authors: Ting
authors: T
authors: Yang
authors: Tao
authors: T
authors: Wang
authors: Lei
authors: L
authors: Chen
authors: Fuqiang
authors: F
authors: Wen
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D060908:CTLA-4 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000503:physiopathology*; D012044:Regression Analysis
chemical_list: D015415:Biomarkers; D060908:CTLA-4 Antigen; D002097:C-Reactive Protein