title: Prognostic significance of peripheral monocyte count in patients with extranodal natural killer/T-cell lymphoma.
abstract: BACKGROUND
  Extranodal natural killer/T-cell lymphoma (ENKL) has heterogeneous clinical manifestations and prognosis. This study aims to evaluate the prognostic impact of absolute monocyte count (AMC) in ENKL, and provide some immunologically relevant information for better risk stratification in patients with ENKL.
  
  
  METHODS
  Retrospective data from 163 patients newly diagnosed with ENKL were analyzed. The absolute monocyte count (AMC) at diagnosis was analyzed as continuous and dichotomized variables. Independent prognostic factors of survival were determined by Cox regression analysis.
  
  
  RESULTS
  The AMC at diagnosis were related to overall survival (OS) and progression-free survival (PFS) in patients with ENKL. Multivariate analysis identified AMC as independent prognostic factors of survival, independent of International Prognostic Index (IPI) and Korean prognostic index (KPI). The prognostic index incorporating AMC and absolute lymphocyte count (ALC), another surrogate factor of immune status, could be used to stratify all 163 patients with ENKL into different prognostic groups. For patients who received chemotherapy followed by radiotherapy (102 cases), the three AMC/ALC index categories identified patients with significantly different survivals. When superimposed on IPI or KPI categories, the AMC/ALC index was better able to identify high-risk patients in the low-risk IPI or KPI category.
  
  
  CONCLUSIONS
  The baseline peripheral monocyte count is shown to be an effective prognostic indicator of survival in ENKL patients. The prognostic index related to tumor microenvironment might be helpful to identify high-risk patients with ENKL.
authors: State Key Laboratory of Oncology in South China, Guangzhou, China.
authors: Jia-Jia
authors: JJ
authors: Huang
authors: Ya-Jun
authors: YJ
authors: Li
authors: Yi
authors: Y
authors: Xia
authors: Yu
authors: Y
authors: Wang
authors: Wen-Xiao
authors: WX
authors: Wei
authors: Ying-Jie
authors: YJ
authors: Zhu
authors: Tong-Yu
authors: TY
authors: Lin
authors: Hui-Qiang
authors: HQ
authors: Huang
authors: Wen-Qi
authors: WQ
authors: Jiang
authors: Zhi-Ming
authors: ZM
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007958:Leukocyte Count; D054391:Lymphoma, Extranodal NK-T-Cell / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009000:Monocytes; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment; D055815:Young Adult
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