title: 2-Aminobenzothiazole derivatives: search for new antifungal agents.
abstract: A new series of 6-substituted 2-aminobenzothiazole derivatives were synthesized and screened in vitro as potential antimicrobials. Almost all the compounds showed antifungal activity. In particular, compounds 1n,o, designed on the basis of molecular modeling studies, were the best of the series, showing MIC values of 4-8 μg/mL against Candida albicans, Candida parapsilosis and Candida tropicalis. None of the two compounds did show any cytotoxicity effect on human THP-1 cells.
authors: Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", via E. Orabona n. 4, 70125 Bari, Italy.
authors: Alessia
authors: A
authors: Catalano
authors: Alessia
authors: A
authors: Carocci
authors: Ivana
authors: I
authors: Defrenza
authors: Marilena
authors: M
authors: Muraglia
authors: Antonio
authors: A
authors: Carrieri
authors: Françoise
authors: F
authors: Van Bambeke
authors: Antonio
authors: A
authors: Rosato
authors: Filomena
authors: F
authors: Corbo
authors: Carlo
authors: C
authors: Franchini
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D052160:Benzothiazoles; C523775:aminobenzothiazole compound