title: A case of the large cell neuroendocrine carcinoma of the urinary bladder.
abstract: Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is very rare. Definite treatment strategy has not been established and prognosis of the disease is not clear yet. We report a case of primary LCNEC of the urinary bladder here with some review of the literature. The patient was a 84-year-old man. He underwent transurethral resection of bladder tumor (TURBT). Histological examination revealed a rosette arrangement of the tumor cells by HE staining and immunohistochemical study revealed positive CD 56, synaptophysin, and chromogranin A (LCNEC). After TURBT, he has no sign of recurrence for 8 months. We have to strictly observe the progress because LCNEC is very aggressive.
authors: Department of Urology, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, Beppu City, Oita 874-0011, Japan.
authors: Shinro
authors: S
authors: Hata
authors: Yoshihisa
authors: Y
authors: Tasaki
references: Mod Pathol. 2011 Aug;24(8):1120-7
references: 21499238
references: Am J Surg Pathol. 2006 Jun;30(6):684-93
references: 16723845
references: BJU Int. 2009 Jun;103(11):1464-70
references: 19254281
references: Arch Pathol Lab Med. 2002 Oct;126(10):1229-32
references: 12296766
references: Mod Pathol. 1998 Oct;11(10):1016-20
references: 9796733
references: Arch Pathol Lab Med. 1986 Nov;110(11):1062-6
references: 3778122
references: Int J Urol. 2008 Dec;15(12):1080-3
references: 19120517
references: Pathol Int. 2006 Nov;56(11):688-93
references: 17040293
references: Am J Surg Pathol. 1991 Jun;15(6):529-53
references: 1709558
references: Breast Cancer. 2012 Oct;19(4):360-4
references: 19669861
references: Pathology. 1999 May;31(2):158-61
references: 10399173
references: Arch Esp Urol. 2011 Mar;64(2):105-13
references: 21399243