title: Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer.
abstract: High-throughput techniques have identified numerous antisense (AS) transcripts and long non-coding RNAs (ncRNAs). However, their significance in cancer biology remains largely unknown. Here, we report an androgen-responsive long ncRNA, CTBP1-AS, located in the AS region of C-terminal binding protein 1 (CTBP1), which is a corepressor for androgen receptor. CTBP1-AS is predominantly localized in the nucleus and its expression is generally upregulated in prostate cancer. CTBP1-AS promotes both hormone-dependent and castration-resistant tumour growth. Mechanistically, CTBP1-AS directly represses CTBP1 expression by recruiting the RNA-binding transcriptional repressor PSF together with histone deacetylases. CTBP1-AS also exhibits global androgen-dependent functions by inhibiting tumour-suppressor genes via the PSF-dependent mechanism thus promoting cell cycle progression. Our findings provide new insights into the functions of ncRNAs that directly contribute to prostate cancer progression.
authors: Department of Anti-Aging Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors: Ken-Ichi
authors: K
authors: Takayama
authors: Kuniko
authors: K
authors: Horie-Inoue
authors: Shintaro
authors: S
authors: Katayama
authors: Takashi
authors: T
authors: Suzuki
authors: Shuichi
authors: S
authors: Tsutsumi
authors: Kazuhiro
authors: K
authors: Ikeda
authors: Tomohiko
authors: T
authors: Urano
authors: Tetsuya
authors: T
authors: Fujimura
authors: Kiyoshi
authors: K
authors: Takagi
authors: Satoru
authors: S
authors: Takahashi
authors: Yukio
authors: Y
authors: Homma
authors: Yasuyoshi
authors: Y
authors: Ouchi
authors: Hiroyuki
authors: H
authors: Aburatani
authors: Yoshihide
authors: Y
authors: Hayashizaki
authors: Satoshi
authors: S
authors: Inoue
mesh_terms: D000368:Aged; D000429:Alcohol Oxidoreductases / Q000096:biosynthesis / Q000235:genetics; D000818:Animals; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006655:Histone Deacetylases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D000072670:PTB-Associated Splicing Factor; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D000072670:PTB-Associated Splicing Factor; D062085:RNA, Long Noncoding; D012334:RNA, Neoplasm; D016601:RNA-Binding Proteins; D011944:Receptors, Androgen; D000429:Alcohol Oxidoreductases; C096794:C-terminal binding protein; D006655:Histone Deacetylases
references: Cell. 2009 Jul 23;138(2):245-56
references: 19632176
references: Cancer Cell. 2010 Jul 13;18(1):11-22
references: 20579941
references: FEBS Lett. 2002 Nov 6;531(2):109-14
references: 12417296
references: Mol Endocrinol. 2012 May;26(5):748-61
references: 22456197
references: Br J Cancer. 1999 Sep;81(2):242-51
references: 10496349
references: RNA Biol. 2009 Jul-Aug;6(3):233-6
references: 19411842
references: Nature. 2009 Mar 12;458(7235):223-7
references: 19182780
references: Neoplasia. 2004 Jan-Feb;6(1):1-6
references: 15068665
references: Cancer Res. 2001 Oct 15;61(20):7544-51
references: 11606392
references: Cancer Res. 2009 Jan 1;69(1):137-42
references: 19117996
references: Mol Cell Biol. 2001 Apr;21(7):2298-311
references: 11259580
references: Cancer Res. 2009 Feb 1;69(3):731-4
references: 19155295
references: Cancer Res. 2001 Mar 1;61(5):2112-8
references: 11280774
references: Nature. 2003 Apr 17;422(6933):735-8
references: 12700765
references: Prostate. 2008 Jun 1;68(8):839-48
references: 18302198
references: Cancer Res. 2006 Mar 1;66(5):2815-25
references: 16510604
references: Nature. 2008 Jan 10;451(7175):202-6
references: 18185590
references: Science. 2005 Sep 2;309(5740):1564-6
references: 16141073
references: Oncogene. 2007 Jun 28;26(30):4453-63
references: 17297473
references: Nature. 2007 Apr 19;446(7138):882-7
references: 17392792
references: Nat Protoc. 2009;4(1):44-57
references: 19131956
references: Mol Cell. 2005 Sep 2;19(5):631-42
references: 16137620
references: Mol Cell Biol. 2009 Aug;29(16):4539-51
references: 19506021
references: Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):621-6
references: 14704271
references: Nature. 2005 Sep 15;437(7057):436-9
references: 16079795
references: Science. 2005 Sep 2;309(5740):1559-63
references: 16141072
references: Nat Biotechnol. 2011 Jul 31;29(8):742-9
references: 21804560
references: Cell. 2007 Jun 29;129(7):1311-23
references: 17604720
references: Nature. 2010 Apr 15;464(7291):1071-6
references: 20393566
references: Methods Enzymol. 2005;400:303-16
references: 16399357
references: Neoplasia. 2012 Oct;14(10):905-14
references: 23097625
references: Nat Med. 2004 Jan;10(1):33-9
references: 14702632
references: J Biol Chem. 2001 Oct 19;276(42):38472-9
references: 11504717
references: EMBO J. 2008 Jun 18;27(12):1694-705
references: 18497743
references: Oncogene. 2005 Oct 13;24(45):6773-84
references: 16007156
references: Cell. 2011 May 13;145(4):622-34
references: 21549415
references: Nucleic Acids Res. 2009 Jan;37(1):1-13
references: 19033363
references: Mod Pathol. 2008 Nov;21(11):1371-8
references: 18552821
references: Nat Biotechnol. 2003 Apr;21(4):379-86
references: 12640466
references: Cancer Cell. 2005 Nov;8(5):393-406
references: 16286247
references: N Engl J Med. 2004 Oct 7;351(15):1488-90
references: 15470210
references: Mol Endocrinol. 2010 Oct;24(10):2019-29
references: 20739403
references: Nat Genet. 1999 Apr;21(4):400-4
references: 10192391
references: Oncogene. 2011 Feb 3;30(5):619-30
references: 20890304
references: Int J Biochem Cell Biol. 2007;39(9):1593-607
references: 17336131