title: Coexpression of two mRNA isoforms of insulin-like growth factor-1 gene and mRNA of YB-1 gene in patients with multiple myeloma.
abstract: Coexpression of two mRNA isoforms for insulin-like growth factor-1 (IGF-1A and IGF-1B) and expression of YB-1 mRNA were analyzed in the bone marrow aspirates from 19 patients with multiple myeloma. It was shown that mRNA isoforms for IGF-1A and IGF-1B were mainly expressed in samples with hyperexpression of YB-1 mRNA, and, on the contrary, practically were not expressed (except sporadic cases) in samples with low level of YB-1 mRNA expression. Coexpression of mRNA isoforms for IGF-1A and IGF-1B were observed in 80% patients with multiple myeloma.
authors: N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia. sainHershy@yandex.ru
authors: S S
authors: SS
authors: Shushanov
authors: L G
authors: LG
authors: Mar'ina
authors: T A
authors: TA
authors: Kravtsova
authors: Yu B
authors: YB
authors: Chernykh
authors: E S
authors: ES
authors: Kakpakova
mesh_terms: D000368:Aged; D005260:Female; D015870:Gene Expression; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000378:metabolism*; D059368:RNA Isoforms / Q000096:biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D051840:Y-Box-Binding Protein 1 / Q000235:genetics*
chemical_list: D059368:RNA Isoforms; D012333:RNA, Messenger; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human; D007334:Insulin-Like Growth Factor I