title: Chlamydial intracellular survival strategies.
abstract: Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and the causative agent of blinding trachoma. Although Chlamydia is protected from humoral immune responses by residing within remodeled intracellular vacuoles, it still must contend with multilayered intracellular innate immune defenses deployed by its host while scavenging for nutrients. Here we provide an overview of Chlamydia biology and highlight recent findings detailing how this vacuole-bound pathogen manipulates host-cellular functions to invade host cells and maintain a replicative niche.
authors: Department of Molecular Genetics and Microbiology, Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC 27710, USA.
authors: Robert J
authors: RJ
authors: Bastidas
authors: Cherilyn A
authors: CA
authors: Elwell
authors: Joanne N
authors: JN
authors: Engel
authors: Raphael H
authors: RH
authors: Valdivia
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology; D002690:Chlamydia Infections / Q000276:immunology / Q000382:microbiology* / Q000503:physiopathology; D002692:Chlamydia trachomatis / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D016207:Cytokines / Q000502:physiology; D004847:Epithelial Cells / Q000382:microbiology; D006056:Golgi Apparatus / Q000382:microbiology; D054884:Host-Pathogen Interactions / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D008018:Life Cycle Stages; D026901:Membrane Transport Proteins / Q000502:physiology
chemical_list: D016207:Cytokines; D026901:Membrane Transport Proteins
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