title: Supramolecular hydrogel based on graphene oxides for controlled release system.
abstract: Supramolecular hydrogel drug delivery system that composed of F127 modified small-sized graphene oxide (F127-SGO) and alpha-CD was prepared and the controlled release behavior was studied using doxorubicin hydrochloride (DOX) as a model drug. As compared with native hydrogel formed from F127 and alpha-CD, the SGO-containing hybrid hydrogel system shows multiple binding sites to load drug molecules and a more controllable release process that facilitates to tune the drug delivery system. These properties make the supramolecular hydrogel a potential candidate for controlled drug delivery system.
authors: National Center for Nanoscience and Technology, Beijing 100190, China.
authors: Qian-Yi
authors: QY
authors: Cheng
authors: Bao-Hang
authors: BH
authors: Han
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems; D006108:Graphite / Q000737:chemistry*; D020100:Hydrogels; D018625:Microscopy, Atomic Force; D010087:Oxides / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000970:Antineoplastic Agents; D020100:Hydrogels; D010087:Oxides; D006108:Graphite; D004317:Doxorubicin