title: Retinol palmitate prevents ischemia-induced cell changes in hippocampal neurons through the Notch1 signaling pathway in mice.
abstract: Retinol palmitate, an analog of vitamin A, plays multiple roles in the nervous system, including neural differentiation, axon outgrowth, and neural patterning, and is also an antioxidative agent and thereby potential neuroprotectant for brain ischemia. The present study aimed at investigating the protective effects of retinol palmitate against ischemia-induced brain injury in a bilateral common carotid artery occlusion (BCCAO) model in mice. Ischemia induced by 20-min BCCAO resulted in significant neuronal morphological changes and reactive astrocyte proliferation in the hippocampus, particularly in the CA1 region, and these changes were accompanied by increased Notch1 expression. Intraperitoneal retinol palmitate administration before ischemia reduced ischemic neurons with Notch1 expression; the differences were statistically significant in both the 1.2mg/kg group and 12 mg/kg group. These results show that retinol palmitate prevents brain ischemia-induced neuronal injury with Notch1 expression and that Notch1 signaling could be involved in the neuroprotective mechanism. Retinol palmitate could be a treatment option for human brain infarction.
authors: Department of Neurology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan.
authors: Jun-Ichiro
authors: J
authors: Shimada
authors: Junko
authors: J
authors: Taniguchi
authors: Masahiro
authors: M
authors: Mori
authors: Yasunori
authors: Y
authors: Sato
authors: Hiroyuki
authors: H
authors: Takuwa
authors: Hiroshi
authors: H
authors: Ito
authors: Satoshi
authors: S
authors: Kuwabara
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001253:Astrocytes / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy / Q000473:pathology*; D004195:Disease Models, Animal; D004224:Diterpenes; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000187:drug effects*; D051881:Receptor, Notch1 / Q000378:metabolism*; D012039:Regional Blood Flow / Q000187:drug effects; D015424:Reperfusion; D000084562:Retinyl Esters; D015398:Signal Transduction / Q000187:drug effects*; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D004224:Diterpenes; D051881:Receptor, Notch1; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate
keywords: Brain infarction; Ischemia; Neuroprotection; Notch1; Retinol palmitate