title: Long-term efficacy of stereotactic bilateral anterior cingulotomy and bilateral anterior capsulotomy as a treatment for refractory obsessive-compulsive disorder.
abstract: OBJECTIVE
  To investigate the long-term efficacy and adverse effects of stereotactic bilateral anterior cingulotomy (BACI) and bilateral anterior capsulotomy (BACA) as a treatment for refractory obsessive-compulsive disorder (OCD) patients.
  
  
  METHODS
  Seven patients suffering from refractory OCD underwent stereotactic surgery and were followed for 12 months. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was used to assess the efficacy. The test was taken before and 6 and 12 months after surgery.
  
  
  RESULTS
  The mean Y-BOCS scores decreased signiﬁcantly from 32.9 ± 4.7 at baseline to 20.6 ± 5.3 after 12 months. Five out of the 7 patients showed a decrease of more than 35%. During the 12-month follow-up, the effective rate had increased from 28.6 to 71.4%. There were no significant adverse effects observed after surgery.
  
  
  CONCLUSIONS
  The BACI and BACA were effective for the treatment of refractory OCD, and no significant adverse effects on long-term follow-up were found.
authors: Department of Neurosurgery, The Affiliated Southeast Hospital of Xiamen University, Zhangzhou, China.
authors: Q J
authors: QJ
authors: Zhang
authors: W H
authors: WH
authors: Wang
authors: X P
authors: XP
authors: Wei
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006179:Gyrus Cinguli / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D019635:Neurosurgical Procedures / Q000379:methods* / Q000639:trends; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000523:psychology / Q000601:surgery*; D011612:Psychosurgery / Q000379:methods* / Q000639:trends; D013238:Stereotaxic Techniques / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome