title: The actin cytoskeleton in presynaptic assembly.
abstract: Dramatic morphogenetic processes underpin nearly every step of nervous system development, from initial neuronal migration and axon guidance to synaptogenesis. Underlying this morphogenesis are dynamic rearrangements of cytoskeletal architecture. Here we discuss the roles of the actin cytoskeleton in the development of presynaptic terminals, from the elaboration of terminal arbors to the recruitment of presynaptic vesicles and active zone components. The studies discussed here underscore the importance of actin regulation at every step in neuronal circuit assembly.
authors: Program in Cellular Neuroscience, Neurodegeneration and Repair; Department of Cell Biology; Yale University; New Haven, CT USA.
authors: Jessica C
authors: JC
authors: Nelson
authors: Andrea K H
authors: AK
authors: Stavoe
authors: Daniel A
authors: DA
authors: Colón-Ramos
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism*; D008954:Models, Biological; D013569:Synapses / Q000378:metabolism*; D013572:Synaptic Vesicles / Q000378:metabolism
chemical_list: D000199:Actins
keywords: actin; active zone; synapse; synaptic adhesion; synaptic vesicle clustering; terminal arborization
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