title: Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation.
abstract: Aggressive chemotherapy/radiotherapy and bone marrow transplantation can cure >90% of girls and young women affected by disorders requiring such treatment. However, the ovaries are very sensitive to cytotoxic drugs, especially to alkylating agents. Several options are currently available to preserve fertility in cancer patients. The present review reports the results of 60 orthotopic reimplantations of cryopreserved ovarian tissue performed by three teams, as well as 24 live births reported in the literature to date. Restoration of ovarian activity occurred in almost all cases in the three series. Among the 60 patients, eleven conceived and six of those had already delivered twelve healthy babies. In the future, we are looking to: 1) improve freezing techniques; and 2) enhance the "vascular bed" before reimplantation to increase pregnancy rates. On the other hand, cryopreservation of ovarian tissue may be combined with removal, via puncture, of small antral follicles, making it possible to freeze both ovarian tissue and isolated immature oocytes.
authors: Infertility Research Unit, Société de Recherche pour l'Infertilité, Brussels, Belgium. jacques.donnez@gmail.com
authors: Jacques
authors: J
authors: Donnez
authors: Marie-Madeleine
authors: MM
authors: Dolmans
authors: Antonio
authors: A
authors: Pellicer
authors: Cesar
authors: C
authors: Diaz-Garcia
authors: Maria
authors: M
authors: Sanchez Serrano
authors: Kristen Tryde
authors: KT
authors: Schmidt
authors: Erik
authors: E
authors: Ernst
authors: Valérie
authors: V
authors: Luyckx
authors: Claus Yding
authors: CY
authors: Andersen
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D015925:Cryopreservation / Q000379:methods / Q000639:trends*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced / Q000601:surgery; D009369:Neoplasms / Q000628:therapy; D010053:Ovary / Q000502:physiology* / Q000601:surgery*; D011247:Pregnancy; D012092:Replantation / Q000379:methods / Q000639:trends*
chemical_list: D000970:Antineoplastic Agents