title: Behavioral deficits, abnormal corticosterone, and reduced prefrontal metabolites of adolescent rats subject to early life stress.
abstract: The present study investigated the effect of early life stress in adolescent rats on brain metabolites, serum corticosterone, and depressive-like behavior. A group of rats was subject to early life stress from postnatal day (PND) 1 to 14. A matched control group was studied. Behavioral tests, serum corticosterone and high-resolution proton magnetic resonance spectroscopy were conducted between PND 30 and 40. In this study, adolescent rats exposed to early life stress demonstrated depressive-like behavior and increased serum corticosterone during adolescence. They also showed reduced glutamate, glutamine, and N-acetylaspartate (NAA) levels in the prefrontal cortex. A reduced myo-inositol level, consistent with astroglial deficits, was observed but was not statistically significant. Together, these findings characterize the effect of early life stress on adolescent animals and underscore the long-lasting and detrimental effects of childhood adversities.
authors: Mental Health Center, Shantou University Medical College, Shantou, Guangdong, PR China.
authors: Jie
authors: J
authors: Zhang
authors: Chadi G
authors: CG
authors: Abdallah
authors: Yaowen
authors: Y
authors: Chen
authors: Tianhua
authors: T
authors: Huang
authors: Qingjun
authors: Q
authors: Huang
authors: Chongtao
authors: C
authors: Xu
authors: Yeyu
authors: Y
authors: Xiao
authors: Yuzhen
authors: Y
authors: Liu
authors: Yan
authors: Y
authors: Ding
authors: Renhua
authors: R
authors: Wu
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D003863:Depression / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D008297:Male; D008426:Maternal Deprivation; D001523:Mental Disorders / Q000209:etiology / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*
chemical_list: D003345:Corticosterone
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