title: Potential therapeutic effects of pigment epithelium-derived factor for treatment of diabetic retinopathy.
abstract: Diabetic retinopathy (DR), a major micro-vascular complication of diabetes, has emerged as a leading cause of visual impairment and blindness among working adults in the worldwide. The pathobiology of DR involves multiple molecular pathways and is characterized chronic neurovascular degeneration. Current approaches to prevent or to treat DR are still far from satisfactory. Therefore, it is important to develop new therapeutic strategies for the prevention and treatment to DR. Pigment epithelium-derived factor (PEDF), a 50-kDa secreted glycoprotein, has been described as a multi-functional protein. Some emerging evidences indicate that PEDF are able to target multiple pathways exerting neurotropic, neuroprotective, anti-angiogenic, antivasopermeability, anti-inflammation, anti-thrombogenic and anti-oxidative effects in DR. In this review, we addressed the functions of PEDF in different pathways, which could lead to potential therapeutics on the treatment to DR.
authors: Department of Ophthalmology, Institution of Ophthalmic Center, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha 410011, Hunan Province, China.
authors: Xiao
authors: X
authors: Liu
authors: Hui-Hui
authors: HH
authors: Chen
authors: Li-Wei
authors: LW
authors: Zhang
keywords: diabetic retinopathy; molecular therapeutics; pigment epithelium derived factor; pleiotropic functions
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