title: [The effect of berberine administration of evaluation of the functional state of rat liver after ligation of common bile duct].
abstract: On the eighth day after ligation of the common bile duct in rats a significant increase in the serum content of total lipids, cholesterol bilirubin and ALT, alkaline phosphatase, and gamma-glutamyltransferase was observed. In the microsomal fraction there was a marked decrease in the content and activity of microsomal monooxygenases. Introperitoneal injection of berberine (10 mg/kg) for 6 days caused a partial normalization of permeability of hepatocytes plasma membranes and activity microsomal flavin-containing monooxygenases. It is suggested that berberine is a substrate and inducer of flavin-containing monooxygenases. Membrane-stabilizing effect of berberine is probably realized at the level of inhibition of prooxidant status of liver cells.
authors: I V
authors: IV
authors: Zverinskiĭ
authors: N G
authors: NG
authors: Mel'nichenko
authors: V A
authors: VA
authors: Poplavskiĭ
authors: I P
authors: IP
authors: Sut'ko
authors: P G
authors: PG
authors: Telegin
authors: A G
authors: AG
authors: Shliakhtun
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D003135:Common Bile Duct / Q000601:surgery*; D020536:Enzyme Activators / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D008026:Ligation / Q000009:adverse effects; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D020536:Enzyme Activators; D008055:Lipids; D001599:Berberine; D006899:Mixed Function Oxygenases; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase