title: One-pot synthesis of 2,5-disubstituted pyrimidines from nitriles.
abstract: A practical, one-step process for the synthesis of 2,5-disubstituted pyrimidines is presented. The protocol proved to be general for the synthesis of a variety of pyrimidine-containing compounds bearing an assortment of functional groups.
authors: Chemical Development US, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States. rogelio.frutos@boehringer-ingelheim.com
authors: Rogelio P
authors: RP
authors: Frutos
authors: Xudong
authors: X
authors: Wei
authors: Nitinchandra D
authors: ND
authors: Patel
authors: Thomas G
authors: TG
authors: Tampone
authors: Jason A
authors: JA
authors: Mulder
authors: Carl A
authors: CA
authors: Busacca
authors: Chris H
authors: CH
authors: Senanayake
mesh_terms: D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009570:Nitriles; D011743:Pyrimidines