title: Molecular evolution of human adenoviruses.
abstract: The recent emergence of highly virulent human adenoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny. Here we report complete high quality genome sequences and analyses for all the previously unsequenced HAdV serotypes (n = 20) within HAdV species D. Analysis of nucleotide sequence variability for these in conjunction with another 40 HAdV prototypes, comprising all seven HAdV species, confirmed the uniquely hypervariable regions within species. The mutation rate among HAdV-Ds was low when compared to other HAdV species. Homologous recombination was identified in at least two of five examined hypervariable regions for every virus, suggesting the evolution of HAdV-Ds has been highly dependent on homologous recombination. Patterns of alternating GC and AT rich motifs correlated well with hypervariable region recombination sites across the HAdV-D genomes, suggesting foci of DNA instability lead to formulaic patterns of homologous recombination and confer agility to adenovirus evolution.
authors: Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.
authors: Christopher M
authors: CM
authors: Robinson
authors: Gurdeep
authors: G
authors: Singh
authors: Jeong Yoon
authors: JY
authors: Lee
authors: Shoaleh
authors: S
authors: Dehghan
authors: Jaya
authors: J
authors: Rajaiya
authors: Elizabeth B
authors: EB
authors: Liu
authors: Mohammad A
authors: MA
authors: Yousuf
authors: Rebecca A
authors: RA
authors: Betensky
authors: Morris S
authors: MS
authors: Jones
authors: David W
authors: DW
authors: Dyer
authors: Donald
authors: D
authors: Seto
authors: James
authors: J
authors: Chodosh
mesh_terms: D000258:Adenovirus Infections, Human / Q000235:genetics / Q000821:virology*; D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics; D019143:Evolution, Molecular; D016679:Genome, Viral; D006801:Humans; D010802:Phylogeny; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral
references: Arch Pathol Lab Med. 2001 Aug;125(8):1042-6
references: 11473454
references: Mol Cell. 2005 Jan 7;17(1):121-35
references: 15629723
references: BMC Genomics. 2006 Jun 13;7:150
references: 16772042
references: Virology. 1987 May;158(1):235-8
references: 3033891
references: J Med Microbiol. 2010 Nov;59(Pt 11):1387-1390
references: 20671084
references: J Virol. 2002 Jan;76(2):755-66
references: 11752165
references: Pathology. 2011 Aug;43(5):488-94
references: 21670723
references: PLoS One. 2010 Jun 25;5(6):e11321
references: 20593015
references: Infect Genet Evol. 2011 Aug;11(6):1208-17
references: 21570490
references: Cell. 1985 Dec;43(3 Pt 2):695-703
references: 3000612
references: Bioinformatics. 2007 Nov 1;23(21):2947-8
references: 17846036
references: Emerg Infect Dis. 2006 Jun;12(6):921-30
references: 16707047
references: Bioinformatics. 2009 Jun 1;25(11):1451-2
references: 19346325
references: J Virol. 2012 Apr;86(8):4693-5
references: 22301156
references: J Clin Virol. 2009 Sep;46(1):80-4
references: 19577957
references: Immunol Rev. 1999 Apr;168:121-30
references: 10399069
references: Bioinformatics. 2008 Dec 1;24(23):2672-6
references: 18845581
references: J Med Virol. 2012 Aug;84(8):1157-65
references: 22711343
references: Nature. 1988 Jul 14;334(6178):124-9
references: 2968522
references: J Virol. 1995 Jan;69(1):131-40
references: 7983703
references: J Mol Biol. 2006 Feb 17;356(2):510-20
references: 16375921
references: Clin Microbiol Rev. 1992 Jul;5(3):262-74
references: 1323383
references: Curr Top Microbiol Immunol. 2004;273:29-85
references: 14674598
references: Virology. 2011 Jan 20;409(2):141-7
references: 21056888
references: J Gen Virol. 2011 Jun;92(Pt 6):1251-1259
references: 21402595
references: J Gen Virol. 2007 Jan;88(Pt 1):298-315
references: 17170463
references: Bioinformatics. 2010 Oct 1;26(19):2462-3
references: 20798170
references: J Virol. 2007 Aug;81(15):8270-81
references: 17522221
references: J Clin Microbiol. 1999 Dec;37(12):3940-5
references: 10565911
references: FEBS J. 2010 Feb;277(3):571-89
references: 20015080
references: Am J Surg Pathol. 1998 Sep;22(9):1101-6
references: 9737243
references: J Clin Microbiol. 2010 Mar;48(3):991-3
references: 20042633
references: J Virol. 2009 Sep;83(17):8980-5
references: 19553309
references: PLoS One. 2009 Jun 03;4(6):e5635
references: 19492050
references: Virology. 1981 Jul 15;112(1):198-209
references: 6264680
references: Mol Biol Evol. 2007 Aug;24(8):1596-9
references: 17488738
references: Cell. 1977 Sep;12(1):1-8
references: 902310
references: Biochem Soc Trans. 2011 Jan;39(1):15-9
references: 21265740
references: Science. 2006 Mar 17;311(5767):1576-80
references: 16439620
references: J Biol Chem. 1991 Apr 15;266(11):6667-9
references: 2016280
references: J Med Virol. 2011 Nov;83(11):1951-8
references: 21915870
references: Virology. 2002 Apr 25;296(1):94-106
references: 12036321
references: J Virol. 1997 May;71(5):3799-810
references: 9094655
references: J Virol. 1996 Mar;70(3):1836-44
references: 8627708
references: Bioinformatics. 2000 Oct;16(10):944-5
references: 11120685
references: J Clin Virol. 2012 Feb;53(2):145-50
references: 22138300
references: J Clin Microbiol. 2005 Nov;43(11):5743-52
references: 16272512
references: Cold Spring Harb Symp Quant Biol. 2009;74:355-62
references: 19717539
references: Trends Microbiol. 2004 Apr;12(4):162-9
references: 15051066
references: Nucleic Acids Res. 1983 Sep 10;11(17):6003-20
references: 6310523
references: Genetics. 2006 Jul;173(3):1705-23
references: 16624913
references: Proc Natl Acad Sci U S A. 1977 Aug;74(8):3171-5
references: 269380