title: Levonorgestrel intrauterine system as a treatment option for severe menorrhagia in adolescent with type III von Willebrand disease.
abstract: The authors describe a case of an adolescent with type III von Willebrand disease and severe menorrhagia since menarche. Antifibrinolytic, hormonal (estroprogestative pill in high doses, etonogestrel implant and gonadotropin-releasing hormone agonist goserelin) and Von Willebrand Factor/Factor VIII replacement therapies were prescribed to the patient, but symptomatic control was only obtained with high doses of VWF/FVIII twice a week. In March 2012, a levonorgestrel intrauterine system was inserted in a 14-year-old. At present, the patient is asymptomatic without regular prophylaxis (VWF/FVIII replacement therapy) and has had a remarkable improvement in her quality of life.
authors: Department of Obstetrics and Gynecology, Bissaya Barreto Maternity Hospital, Coimbra, Portugal.
authors: Carla Donato
authors: CD
authors: Silva
authors: Fernanda
authors: F
authors: Geraldes
authors: Isabel Santos
authors: IS
authors: Silva
mesh_terms: D000293:Adolescent; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007434:Intrauterine Devices; D016912:Levonorgestrel / Q000008:administration & dosage / Q000627:therapeutic use*; D008595:Menorrhagia / Q000188:drug therapy* / Q000209:etiology; D014842:von Willebrand Diseases / Q000150:complications*
chemical_list: D003271:Contraceptive Agents, Female; D016912:Levonorgestrel
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