title: Jejunoileal bypass as the main procedure in the onset of immune-related conditions: the model of BADAS.
abstract: Bariatric surgery represents a common approach for the control of severe morbid obesity, reducing caloric intake by modifying the anatomy of the gastrointestinal tract. Following jejunoileal bypass, a large spectrum of complications has been described, with rheumatic manifestation present in up to 20% of cases. Although bowel bypass syndrome, also called blind loop syndrome, is a well-recognized complication of jejunoileal bypass, the same syndrome was recognized in patients who had not had intestinal bypass surgery, and the term the 'bowel-associated dermatosis-arthritis syndrome' (BADAS) was coined. The pathogenesis of BADAS is as yet poorly understood and only few data concerning this issue have been published in the literature. The aim of the present paper is to review the literature and to discuss putative pathogenic mechanisms of BADAS, focusing on the immune system.
authors: Department of Clinical Science and Biotechnology, Rheumatology Unit, University of L'Aquila, L'Aquila, Italy. francescocarubbi@libero.it
authors: Francesco
authors: F
authors: Carubbi
authors: Piero
authors: P
authors: Ruscitti
authors: Ilenia
authors: I
authors: Pantano
authors: Saverio
authors: S
authors: Alvaro
authors: Paola Di
authors: PD
authors: Benedetto
authors: Vasiliki
authors: V
authors: Liakouli
authors: Antonio
authors: A
authors: Giuliani
authors: Federica
authors: F
authors: Piccione
authors: Francesco
authors: F
authors: Ciccia
authors: Gianfranco
authors: G
authors: Amicucci
authors: Giovanni
authors: G
authors: Triolo
authors: Roberto
authors: R
authors: Giacomelli
authors: Paola
authors: P
authors: Cipriani
mesh_terms: D001168:Arthritis / Q000276:immunology / Q000503:physiopathology; D001765:Blind Loop Syndrome / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007581:Jejunoileal Bypass / Q000009:adverse effects*; D012778:Short Bowel Syndrome / Q000276:immunology / Q000503:physiopathology; D012871:Skin Diseases / Q000276:immunology / Q000503:physiopathology