title: NSAID single-drug-induced reactions.
abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are cyclooxygenase inhibitors with analgesic, anti-inflammatory, antipyretic, and antithrombotic effects. NSAIDs have been implicated in a variety of drug-induced reactions that are proved as or suspected of being mediated through a host immune response. Single-drug-induced reactions are the hallmark of these types of reactions. The types of single-drug-induced reactions are the confluence of 2 variables, the structure of the drug and the specific types of immune responses. This article identifies reactions patterns and the NSAIDs most likely to elicit each immune response.
authors: Scripps Allergy and Immunology Fellowship Program, Division of Allergy and Immunology, Scripps Clinic, San Diego, CA 92130, USA. Woessner.katharine@scrippshealth.org
authors: Katharine M
authors: KM
authors: Woessner
authors: Mariana
authors: M
authors: Castells
mesh_terms: D000707:Anaphylaxis / Q000209:etiology; D000799:Angioedema / Q000209:etiology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D014581:Urticaria / Q000209:etiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal