title: Effects of cerium oxide nanoparticles on PC12 neuronal-like cells: proliferation, differentiation, and dopamine secretion.
abstract: OBJECTIVE
  Oxidative stress has been found to play a key role in several diseases, that range from cancer to neurodegenerative disorders. Besides traditional anti-oxidant agents, in recent years much attention has been focused on nanotechnological solutions, including cerium oxide nanoparticles (nanoceria).
  
  
  METHODS
  Thanks to its extraordinary catalytic properties, nanoceria mimics the activity of superoxide dismutase and of catalase, therefore acting as a reactive oxygen species (ROS) scavenger in many biological contexts. In this paper, we report on nanoceria interactions with PC12 cell line, that represents a valuable model for many features of central dopaminergic neurons.
  
  
  RESULTS
  Nanoceria confirmed a strong anti-ROS action but, most interestingly, also showed beneficial effects on both cell differentiation and dopamine production.
  
  
  CONCLUSIONS
  Even if deeper examinations will be necessary in order to better clarify the mechanisms at the base of the documented effects, nanoceria demonstrated a significant potential as pharmacological agent in the treatment of neurological disorders.
authors: Istituto Italiano di Tecnologia, Center for Micro-BioRobotics @SSSA, Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy. gianni.ciofani@iit.it
authors: Gianni
authors: G
authors: Ciofani
authors: Giada G
authors: GG
authors: Genchi
authors: Ioannis
authors: I
authors: Liakos
authors: Valentina
authors: V
authors: Cappello
authors: Mauro
authors: M
authors: Gemmi
authors: Athanassia
authors: A
authors: Athanassiou
authors: Barbara
authors: B
authors: Mazzolai
authors: Virgilio
authors: V
authors: Mattoli
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D002563:Cerium / Q000737:chemistry / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry / Q000378:metabolism*; D016716:PC12 Cells; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D002563:Cerium; C030583:ceric oxide; D004298:Dopamine
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