title: Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci.
abstract: The rearrangement of T and B lymphocyte Ag receptor loci occurs within a highly complex chromosomal environment and is orchestrated through complex mechanisms. During the past decade, a large body of literature has highlighted the significance of chromatin architecture at Ag receptor loci in supporting the genomic assembly process: in preparation for recombination, these loci tend to contract and form multiple loops that shorten the distances between gene segments and facilitate recombination events. CCCTC-binding factor, CTCF, has received much attention in this regard since it has emerged as an important regulator of chromatin organization and transcription. In this review, we summarize recent work outlining conformational dynamics at Ag receptor loci during lymphocyte development and we discuss the role of CTCF in Ag receptor locus conformation and repertoire development.
authors: Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
authors: Han-Yu
authors: HY
authors: Shih
authors: Michael S
authors: MS
authors: Krangel
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D000076246:CCCTC-Binding Factor; D002843:Chromatin / Q000235:genetics*; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000235:genetics*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D012097:Repressor Proteins / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D060152:V(D)J Recombination / Q000276:immunology*
chemical_list: D000076246:CCCTC-Binding Factor; C000619697:CTCF protein, human; D002843:Chromatin; C000619698:Ctcf protein, mouse; D018398:Homeodomain Proteins; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; D012097:Repressor Proteins; C064658:RAG-1 protein
references: J Exp Med. 2005 Aug 15;202(4):467-72
references: 16087716
references: Eur J Immunol. 2001 Jul;31(7):2080-6
references: 11449361
references: Science. 2002 Apr 5;296(5565):158-62
references: 11935030
references: Nature. 2008 Feb 14;451(7180):796-801
references: 18235444
references: Cell. 2007 Mar 23;128(6):1231-45
references: 17382889
references: Semin Immunol. 2010 Dec;22(6):313-22
references: 20829065
references: PLoS Genet. 2009 Nov;5(11):e1000739
references: 19956766
references: Cell. 2008 Feb 8;132(3):422-33
references: 18237772
references: Curr Opin Cell Biol. 2011 Jun;23(3):318-24
references: 21169003
references: Nature. 2011 Sep 11;477(7365):424-30
references: 21909113
references: Science. 2009 Oct 9;326(5950):289-93
references: 19815776
references: Cell. 2009 Jun 26;137(7):1194-211
references: 19563753
references: Nucleic Acids Res. 2012 Sep;40(16):7753-65
references: 22718969
references: Curr Opin Immunol. 2009 Apr;21(2):133-9
references: 19362456
references: Nat Genet. 2006 Nov;38(11):1348-54
references: 17033623
references: Nat Immunol. 2005 Jan;6(1):31-41
references: 15580273
references: Cell. 2010 Apr 30;141(3):419-31
references: 20398922
references: Genes Dev. 2005 Feb 1;19(3):322-7
references: 15687256
references: Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9566-71
references: 21606361
references: J Immunol. 2011 May 1;186(9):5356-66
references: 21441452
references: Annu Rev Genet. 2011;45:167-202
references: 21854230
references: Nat Immunol. 2007 Apr;8(4):378-87
references: 17334367
references: Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):E3493-502
references: 23169622
references: Nature. 2010 Sep 23;467(7314):430-5
references: 20720539
references: J Exp Med. 2007 Dec 24;204(13):3247-56
references: 18056289
references: Nat Rev Genet. 2010 Jun;11(6):391-404
references: 20442714
references: Immunity. 1996 Oct;5(4):331-42
references: 8885866
references: Nucleic Acids Res. 2008 Sep;36(16):5221-31
references: 18684996
references: Annu Rev Immunol. 2012;30:337-56
references: 22224771
references: Nat Immunol. 2002 May;3(5):469-76
references: 11967541
references: Genes Dev. 2007 May 15;21(10):1179-89
references: 17504937
references: Curr Opin Genet Dev. 2012 Apr;22(2):79-85
references: 22169023
references: Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):903-7
references: 17210914
references: Immunity. 2011 Feb 25;34(2):175-87
references: 21349430
references: Cell. 2011 Oct 14;147(2):332-43
references: 21982154
references: Annu Rev Immunol. 2006;24:541-70
references: 16551259
references: Genome Res. 2010 May;20(5):578-88
references: 20219941
references: Immunity. 2011 Oct 28;35(4):501-13
references: 22035845
references: Genes Dev. 2004 Feb 15;18(4):411-22
references: 15004008
references: Immunity. 2006 Apr;24(4):405-15
references: 16618599
references: Adv Exp Med Biol. 2009;650:82-92
references: 19731803
references: Curr Opin Immunol. 2009 Apr;21(2):173-8
references: 19359154
references: Nat Genet. 2011 Jun 19;43(7):630-8
references: 21685913
references: Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17004-9
references: 23027941
references: Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3651-6
references: 20133600
references: J Biol Chem. 2011 May 20;286(20):17870-8
references: 21454523
references: Nat Rev Immunol. 2011 Apr;11(4):251-63
references: 21394103
references: Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7145-50
references: 17442748
references: Curr Opin Genet Dev. 2013 Apr;23(2):89-95
references: 23270812
references: Nature. 2012 Aug 2;488(7409):116-20
references: 22763441
references: Mol Cell Biol. 2005 Feb;25(4):1511-25
references: 15684400
references: J Immunol. 2012 Mar 15;188(6):2556-66
references: 22345664
references: Genome Res. 2009 Jan;19(1):24-32
references: 19056695
references: EMBO J. 2012 Apr 4;31(7):1666-78
references: 22373576
references: J Exp Med. 2002 Nov 4;196(9):1163-73
references: 12417627
references: J Immunol. 2013 Feb 15;190(4):1819-26
references: 23296705
references: Genes Dev. 2012 Jan 1;26(1):11-24
references: 22215806
references: Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8309-14
references: 18550811
references: Nature. 2012 Apr 11;485(7398):376-80
references: 22495300
references: Science. 2002 Feb 15;295(5558):1306-11
references: 11847345
references: Nat Genet. 2006 Nov;38(11):1341-7
references: 17033624
references: Nat Immunol. 2008 Aug;9(8):927-36
references: 18568028
references: Cell. 2009 Aug 7;138(3):435-48
references: 19665968
references: Nature. 2012 Sep 6;489(7414):109-13
references: 22955621
references: Trends Genet. 2007 Mar;23(3):126-33
references: 17280735
references: J Immunol. 2010 Jun 1;184(11):5964-8
references: 20435935
references: J Immunol. 2009 Jan 1;182(1):44-8
references: 19109133
references: PLoS Comput Biol. 2010 Feb 19;6(2):e1000682
references: 20174554
references: J Exp Med. 2010 Aug 30;207(9):1835-41
references: 20696701
references: Cell. 2008 Apr 18;133(2):265-79
references: 18423198
references: Nat Immunol. 2012 Dec;13(12):1196-204
references: 23064439
references: Nature. 2011 Aug 10;476(7361):467-71
references: 21832993