title: Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa.
abstract: Five new quinolone alkaloids, euocarpines A-E (16-20), four new natural products (1, 4, 12, and 14), and eleven known natural products were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth. The structures of the new compounds were elucidated based on spectroscopic evidence. All compounds were evaluated for their antibacterial activity against three strains and for their cytotoxic activity against four human tumor cell lines. The results revealed that 5, 7-11, 13, 14, and 16-20 exhibited moderate antibacterial activities (MIC values: 4-128 μg/mL), and 9, 11, 14, and 17 exhibited moderate cytotoxic activities against HepG-2, Hela, BEL7402, and BEL7403 (IC50 values: 15.85-56.36 μM).
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
authors: Xiao-Xia
authors: XX
authors: Wang
authors: Ke
authors: K
authors: Zan
authors: She-Po
authors: SP
authors: Shi
authors: Ke-Wu
authors: KW
authors: Zeng
authors: Yong
authors: Y
authors: Jiang
authors: Yan
authors: Y
authors: Guan
authors: Chun-Ling
authors: CL
authors: Xiao
authors: Hui-Yuan
authors: HY
authors: Gao
authors: Li-Jun
authors: LJ
authors: Wu
authors: Peng-Fei
authors: PF
authors: Tu
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D032086:Evodia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D015363:Quinolones / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D015363:Quinolones
keywords: Antibacterial activity; Cytotoxic activity; Evodia rutaecarpa; Quinolone alkaloids