title: HDAC6 and ovarian cancer.
abstract: The special class IIb histone deacetylase, HDAC6, plays a prominent role in many cellular processes related to cancer, including oncogenesis, the cell stress response, motility, and myriad signaling pathways. Many of the lessons learned from other cancers can be applied to ovarian cancer as well. HDAC6 interacts with diverse proteins such as HSP90, cortactin, tubulin, dynein, p300, Bax, and GRK2 in both the nucleus and cytoplasm to carry out these cancerous functions. Not all pro-cancer interactions of HDAC6 involve deacetylation. The idea of using HDAC6 as a target for cancer treatment continues to expand in recent years, and more potent and specific HDAC6 inhibitors are required to effectively down-regulate the tumor-prone cell signaling pathways responsible for ovarian cancer.
authors: Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA. xzhang@health.usf.edu.
authors: Joshua
authors: J
authors: Haakenson
authors: Xiaohong
authors: X
authors: Zhang
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000187:drug effects / Q000473:pathology; D002465:Cell Movement / Q000187:drug effects; D005260:Female; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D010051:Ovarian Neoplasms / Q000201:enzymology*; D013312:Stress, Physiological / Q000187:drug effects
chemical_list: D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases
references: J Biol Chem. 2005 Dec 2;280(48):40282-92
references: 16192271
references: Mol Cell Biochem. 2007 Sep;303(1-2):221-30
references: 17516032
references: Curr Opin Genet Dev. 2001 Apr;11(2):162-6
references: 11250139
references: J Biol Chem. 2005 Jul 22;280(29):26729-34
references: 15937340
references: Genes Dev. 2007 Sep 1;21(17):2172-81
references: 17785525
references: Clin Cancer Res. 2004 Oct 15;10(20):6962-8
references: 15501975
references: Immunol Cell Biol. 2012 Jan;90(1):78-84
references: 22124372
references: Oncol Rep. 2012 Mar;27(3):819-24
references: 22089141
references: EMBO J. 2002 Dec 16;21(24):6820-31
references: 12486003
references: EMBO J. 2012 Feb 15;31(4):856-69
references: 22193721
references: Cell. 2009 Sep 4;138(5):1019-31
references: 19698979
references: J Biol Chem. 2011 Mar 18;286(11):9280-6
references: 21220424
references: J Biol Chem. 2009 Oct 30;284(44):30264-74
references: 19744931
references: Biochem Biophys Res Commun. 2006 Mar 3;341(1):45-50
references: 16412385
references: Clin Cancer Res. 2008 Nov 15;14(22):7340-7
references: 19010849
references: Mol Endocrinol. 2009 Dec;23(12):1963-72
references: 19855091
references: Cancer Lett. 2008 Sep 28;269(1):7-17
references: 18462867
references: J Biol Chem. 2004 Nov 12;279(46):48246-54
references: 15347674
references: Science. 2003 Apr 25;300(5619):650-3
references: 12714747
references: Biochem Biophys Res Commun. 2009 May 22;383(1):88-92
references: 19344692
references: Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9633-8
references: 18606987
references: Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13425-30
references: 12354939
references: Trends Genet. 2003 May;19(5):286-93
references: 12711221
references: Arch Gynecol Obstet. 2013 Jun;287(6):1187-204
references: 23503972
references: Biochem Cell Biol. 2001;79(3):337-48
references: 11467747
references: Biochem J. 2003 Mar 15;370(Pt 3):737-49
references: 12429021
references: Biochemistry. 2009 Mar 24;48(11):2377-84
references: 19253956
references: Mol Cell. 2005 May 27;18(5):601-7
references: 15916966
references: Mol Cell Biol. 2002 Nov;22(22):7982-92
references: 12391164
references: Blood. 2008 May 1;111(9):4605-16
references: 18230754
references: ChemMedChem. 2008 Mar;3(3):487-501
references: 18181121
references: Eur J Cell Biol. 2011 Feb-Mar;90(2-3):128-35
references: 20970878
references: Curr Biol. 2006 Nov 7;16(21):2166-72
references: 17084703
references: EMBO J. 2011 Aug 16;30(20):4142-56
references: 21847094
references: Cancer Res. 2009 May 15;69(10):4415-23
references: 19417138
references: J Cell Sci. 2005 Jul 1;118(Pt 13):2901-11
references: 15976449
references: PLoS One. 2012;7(7):e40440
references: 22792322
references: Oncol Rep. 2012 Sep;28(3):867-73
references: 22766642
references: J Biomed Biotechnol. 2011;2011:875824
references: 21076528
references: Structure. 2004 Jul;12(7):1325-34
references: 15242608
references: Dev Cell. 2007 Aug;13(2):161-2
references: 17681125
references: Nat Rev Cancer. 2001 Dec;1(3):194-202
references: 11902574
references: Mol Cell. 2004 Mar 12;13(5):627-38
references: 15023334
references: Cancer Lett. 2009 May 8;277(1):8-21
references: 18824292
references: Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8567-72
references: 15937109
references: Curr Biol. 2005 Jul 26;15(14):1276-85
references: 16051170
references: Am J Physiol Renal Physiol. 2002 Nov;283(5):F904-11
references: 12372765
references: Dev Cell. 2004 Apr;6(4):463-77
references: 15068787
references: J Cell Biol. 1993 Mar;120(6):1417-26
references: 7680654
references: Mol Cell Biol. 2001 Dec;21(23):8035-44
references: 11689694
references: Nature. 2007 Jun 14;447(7146):859-63
references: 17568747
references: Nature. 1999 Sep 9;401(6749):188-93
references: 10490031
references: FASEB J. 2009 Feb;23(2):451-63
references: 18854435
references: Integr Biol (Camb). 2012 May;4(5):540-9
references: 22446682
references: Cell. 2003 Dec 12;115(6):727-38
references: 14675537
references: J Mol Endocrinol. 2002 Oct;29(2):175-92
references: 12370120
references: Cell. 2007 Sep 21;130(6):1005-18
references: 17889646
references: Traffic. 2002 Jun;3(6):388-96
references: 12010457
references: J Neurosci. 2007 Mar 28;27(13):3571-83
references: 17392473
references: Science. 2009 Aug 14;325(5942):834-40
references: 19608861
references: Proc Natl Acad Sci U S A. 1988 Aug;85(16):5946-50
references: 3413068
references: Cancer Res. 2005 May 1;65(9):3883-93
references: 15867388
references: Curr Opin Pharmacol. 2003 Aug;3(4):344-51
references: 12901942
references: Autophagy. 2010 May;6(4):555-7
references: 20404488
references: Eur J Med Chem. 2009 May;44(5):1900-12
references: 19084294
references: EMBO Rep. 2001 Oct;2(10):885-90
references: 11600451
references: Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94
references: 12677000
references: J Cell Biol. 1987 Feb;104(2):289-302
references: 2879846
references: Int J Oncol. 2006 Jul;29(1):117-24
references: 16773191
references: Oncogene. 2005 Jun 30;24(28):4531-9
references: 15806142
references: J Biol Chem. 2012 Mar 30;287(14):10885-93
references: 22334690
references: PLoS One. 2010 May 26;5(5):e10848
references: 20520769
references: J Biol Chem. 2005 Oct 7;280(40):33792-9
references: 16087666
references: Oncogene. 2011 Sep 22;30(38):4050-62
references: 21532619
references: Mol Biol Cell. 2007 Jul;18(7):2603-18
references: 17475769
references: Nat Rev Mol Cell Biol. 2008 Mar;9(3):206-18
references: 18292778
references: Trends Cell Biol. 2000 Dec;10(12):524-30
references: 11121744
references: Mol Cell. 2003 Feb;11(2):437-44
references: 12620231
references: CA Cancer J Clin. 2012 Jul-Aug;62(4):220-41
references: 22700443
references: Biochem Biophys Res Commun. 2006 Oct 6;348(4):1429-35
references: 16919237
references: PLoS One. 2011;6(12):e28563
references: 22174839
references: J Ovarian Res. 2012 Apr 24;5(1):12
references: 22531354
references: J Cell Sci. 2007 Apr 15;120(Pt 8):1469-79
references: 17389687
references: J Exp Med. 2009 Jan 16;206(1):221-32
references: 19124656
references: J Med Chem. 2008 Jun 26;51(12):3437-48
references: 18494463
references: EMBO J. 2006 Jul 26;25(14):3357-66
references: 16810319
references: Cell. 2007 Jun 29;129(7):1351-63
references: 17604723
references: J Cell Biol. 2005 Nov 21;171(4):603-14
references: 16286508
references: Gynecol Oncol. 2010 Dec;119(3):557-63
references: 20825984
references: Sci Signal. 2012 May 15;5(224):pt3
references: 22589388
references: J Biol Chem. 2008 May 9;283(19):12686-90
references: 18356165
references: Trends Cell Biol. 2008 Jun;18(6):291-7
references: 18472263
references: J Med Chem. 2009 Dec 10;52(23):7836-46
references: 19705846
references: J Cell Sci. 2011 May 1;124(Pt 9):1519-32
references: 21486957
references: Br J Cancer. 2007 Nov 19;97(10):1344-53
references: 18000499
references: Mol Cell Proteomics. 2009 Feb;8(2):215-25
references: 18723842
references: Oncogene. 2007 Aug 13;26(37):5468-76
references: 17694087
references: Bioorg Med Chem Lett. 2009 Feb 1;19(3):688-92
references: 19111466
references: Mol Cell Biol. 2008 Mar;28(5):1688-701
references: 18180281
references: Curr Obstet Gynecol Rep. 2012 Mar;1(1):1-9
references: 22506137
references: J Med Chem. 2008 Aug 14;51(15):4370-3
references: 18642892
references: Curr Biol. 2000 Jun 15;10(12):747-9
references: 10873806
references: Nat Med. 2005 Jan;11(1):63-70
references: 15619626
references: J Invest Dermatol. 2002 Aug;119(2):527-31
references: 12190880
references: J Biol Chem. 2006 Feb 3;281(5):2401-4
references: 16272578
references: Cancer Res. 2006 Apr 1;66(7):3773-81
references: 16585204
references: Int J Biochem Cell Biol. 2002 Jul;34(7):746-61
references: 11950592
references: EMBO J. 2011 Sep 27;30(23):4838-49
references: 21952047
references: J Biol Chem. 1997 Dec 26;272(52):32719-22
references: 9407041
references: Mol Cell Biol. 2004 Sep;24(18):8055-68
references: 15340068
references: J Cell Sci. 2004 Jan 15;117(Pt 2):281-92
references: 14657277
references: Biochem Pharmacol. 2012 Sep 15;84(6):756-65
references: 22728920
references: ACS Chem Biol. 2012 Feb 17;7(2):331-9
references: 22047054
references: FEBS J. 2013 Feb;280(3):775-93
references: 23181831
references: Blood. 2012 Nov 15;120(20):4215-8
references: 22955928
references: J Biol Chem. 2012 Aug 17;287(34):29168-74
references: 22778253
references: J Biol Chem. 2010 Apr 9;285(15):11219-26
references: 20133936
references: EMBO J. 1999 Nov 1;18(21):6106-18
references: 10545121
references: J Med Chem. 2010 Dec 9;53(23):8387-99
references: 21073160
references: J Biol Chem. 2010 Nov 12;285(46):36129-37
references: 20826784
references: Cell Motil Cytoskeleton. 1994;27(1):88-96
references: 8194113
references: Cell Death Dis. 2011 Jan 27;2:e117
references: 21368888
references: EMBO J. 2010 Jan 6;29(1):131-44
references: 19893491
references: J Cell Sci. 2009 Oct 1;122(Pt 19):3531-41
references: 19737819
references: Mutat Res. 1999 May 14;434(1):3-15
references: 10377944
references: Genes Dev. 2007 Dec 15;21(24):3381-94
references: 18079183
references: Nat Med. 2011 Jul 24;17(8):968-74
references: 21785432
references: Cancer Res. 2008 Apr 15;68(8):2557-60
references: 18413721
references: Mol Cell. 2007 Jul 20;27(2):197-213
references: 17643370
references: Neoplasia. 2011 Aug;13(8):726-34
references: 21847364
references: Nature. 2002 May 23;417(6887):455-8
references: 12024216
references: Cancer Res. 2008 Sep 15;68(18):7561-9
references: 18794144
references: J Neurosci. 2012 Mar 28;32(13):4400-16
references: 22457490
references: EMBO J. 2003 Mar 3;22(5):1168-79
references: 12606581
references: Blood. 2008 Oct 1;112(7):2917-26
references: 18641367
references: Annu Rev Biochem. 2000;69:277-302
references: 10966460
references: J Neurochem. 2011 Apr;117(1):112-20
references: 21235576
references: Nat Genet. 2004 Jun;36(6):602-6
references: 15122254
references: Mol Cell. 2003 Jan;11(1):139-50
references: 12535528
references: EMBO J. 2010 Mar 3;29(5):969-80
references: 20075865
references: Cell. 2006 Nov 17;127(4):679-95
references: 17110329
references: Leukemia. 2005 Oct;19(10):1751-9
references: 16121216
references: Annu Rev Biochem. 1998;67:425-79
references: 9759494
references: Chem Biol. 2003 May;10(5):383-96
references: 12770821
references: Curr Pharm Des. 2008;14(6):505-28
references: 18336297
references: ChemMedChem. 2009 Feb;4(2):283-90
references: 19090524
references: J Nat Prod. 2011 Oct 28;74(10):2031-8
references: 21793558
references: J Med Chem. 2007 Nov 1;50(22):5425-38
references: 17929798
references: Nat Rev Mol Cell Biol. 2007 Nov;8(11):931-7
references: 17712358