title: Infra-slow oscillation (ISO) of the pupil size of urethane-anaesthetised rats.
abstract: Multiplicity of oscillatory phenomena in a range of infra-slow frequencies (<0.01 Hz) has been described in mammalian brains at different levels of organisation. The significance and manifestation in physiology and/or behaviour of many brain infra-slow oscillations (ISO) remain unknown. Examples of this phenomenon are two types of ISO observed in the brains of urethane-anaesthetised rats: infra-slow, rhythmic changes in the rate of action potential firing in a few nuclei of the subcortical visual system and a sleep-like cycle of activation/deactivation visible in the EEG signal. Because both of these rhythmic phenomena involve brain networks that can influence autonomic nervous system activity, we hypothesised that these two brain ISOs can be reflected by rhythmic changes of pupil size. Thus, in the present study, we used simultaneous pupillography and ECoG recording to verify the hypothesised existence of infra-slow oscillations in the pupil size of urethane-anaesthetised rats. The obtained results showed rhythmic changes in the size of the pupils and rhythmic eyeball movements in urethane-anaesthetised rats. The observed rhythms were characterised by two different dominant components in a range of infra-slow frequencies. First, the long component had a period of ≈ 29 minutes and was present in both the irises and the eyeball movements. Second, the short component had a period of ≈ 2 minutes and was observed only in the rhythmic constrictions and dilations of the pupils. Both ISOs were simultaneously present in both eyes, and they were synchronised between the left and right eye. The long ISO component was synchronised with the cyclic alternations of the brain state, as revealed by rhythmic changes in the pattern of the ECoG signal. Based on the obtained results, we propose a model of interference of ISO present in different brain systems involved in the control of pupil size.
authors: Department of Neurophysiology and Chronobiology, Institute of Zoology, Jagiellonian University, Krakow, Poland. tomasz.blasiak@uj.edu.pl
authors: Tomasz
authors: T
authors: Blasiak
authors: Artur
authors: A
authors: Zawadzki
authors: Marian Henryk
authors: MH
authors: Lewandowski
mesh_terms: D000758:Anesthesia; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D005133:Eye Movements / Q000187:drug effects; D008297:Male; D008954:Models, Biological; D009929:Organ Size / Q000187:drug effects; D009991:Oscillometry; D011680:Pupil / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D014520:Urethane / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014520:Urethane
references: Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5053-7
references: 15044698
references: J Comp Neurol. 1990 Nov 8;301(2):262-75
references: 1702107
references: Brain Res. 1995 Aug 7;688(1-2):34-46
references: 8542320
references: Neuroscience. 2013 Jan 3;228:315-24
references: 23103793
references: Prog Brain Res. 2011;193:145-62
references: 21854961
references: Eur J Neurosci. 2008 May;27(10):2657-64
references: 18547249
references: J Comp Neurol. 2003 Jun 9;460(4):476-86
references: 12717708
references: Prog Brain Res. 2006;151:379-405
references: 16221595
references: Nature. 1957 May 11;179(4567):957-9
references: 13430746
references: Am J Physiol. 1992 Jul;263(1 Pt 2):R51-8
references: 1636794
references: Brain Res. 2004 May 29;1009(1-2):82-7
references: 15120585
references: PLoS One. 2009;4(2):e4447
references: 19212445
references: Neuroscience. 1994 Sep;62(2):481-96
references: 7830893
references: Nature. 2006 Jun 1;441(7093):589-94
references: 16688184
references: J Hirnforsch. 1992;33(2):151-67
references: 1280294
references: Brain Res. 2007 Feb 16;1133(1):78-86
references: 17196561
references: Neuroimage. 2006 Feb 15;29(4):1359-67
references: 16260155
references: J Comp Neurol. 1989 May 8;283(2):285-302
references: 2738199
references: J Comp Neurol. 2005 Jul 18;488(1):28-47
references: 15912497
references: PLoS One. 2008 Apr 16;3(4):e2004
references: 18414674
references: J Glaucoma. 2004 Apr;13(2):100-7
references: 15097254
references: Anat Embryol (Berl). 1998 Aug;198(2):123-32
references: 9725771
references: Neurosci Biobehav Rev. 1997 Sep;21(5):705-27
references: 9353800
references: Cereb Cortex. 2003 Apr;13(4):422-33
references: 12631571
references: Neurosci Lett. 2005 Jan 3;373(1):51-6
references: 15555776
references: Neuron. 2010 May 13;66(3):417-28
references: 20471354
references: J Glaucoma. 2011 Aug;20(6):331-5
references: 21811135
references: Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13848-53
references: 16945915
references: J Comp Neurol. 1998 Jul 6;396(3):288-309
references: 9624585
references: Acta Neurobiol Exp (Wars). 2004;64(2):277-88
references: 15366259
references: J Neurosci. 2002 Apr 1;22(7):2701-10
references: 11923435
references: Nature. 2007 May 3;447(7140):83-6
references: 17476267
references: Prog Brain Res. 2008;173:31-45
references: 18929100
references: Science. 1975 Jul 4;189(4196):55-8
references: 1094539
references: Neuroscience. 2010 Dec 1;171(2):613-21
references: 20837107
references: J Neurosci Methods. 2010 Jan 15;185(2):199-203
references: 19786049
references: J Neurophysiol. 2009 Jan;101(1):100-11
references: 18971301
references: Vision Res. 1979;19(5):569-88
references: 483586
references: J Neurosci. 2008 Aug 13;28(33):8268-72
references: 18701689
references: Rev Oculomot Res. 1988;2:335-64
references: 3153652
references: Neuroreport. 2002 Dec 20;13(18):2487-92
references: 12499854
references: Nat Rev Neurosci. 2007 Sep;8(9):700-11
references: 17704812
references: J Glaucoma. 2009 Mar;18(3):173-9
references: 19295366
references: Neuroreport. 2000 Feb 7;11(2):317-21
references: 10674478
references: Invest Ophthalmol Vis Sci. 1990 Jul;31(7):1332-8
references: 1973158
references: Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13170-5
references: 17670949
references: Brain Res. 2005 Dec 20;1066(1-2):179-86
references: 16324687
references: J Hirnforsch. 1990;31(2):251-7
references: 2358666
references: Curr Opin Ophthalmol. 2011 Mar;22(2):96-101
references: 21252671
references: J Comp Neurol. 2004 Jun 21;474(2):227-45
references: 15164424
references: Int Rev Neurobiol. 1988;30:225-340
references: 3061969