title: Clinical Significance of Wnt/β-Catenin Signalling and Androgen Receptor Expression in Prostate Cancer.
abstract: OBJECTIVE
  To investigate the relationships among the Wnt/β-catenin pathway, androgen receptor (AR), and clinicopathological factors in hormone-naïve prostate cancer.
  
  
  METHODS
  This study was conducted with132 cases of hormone-naïve prostate cancer treated by prostatectomy and prostate needle biopsy. An immunohistochemical study using antibodies against β-catenin, matrix metalloproteinase-7 (MMP-7), and the AR was performed. For the in vitro study, PC-3, LNCaP, 22Rv1, and DU145 cell lines were used.
  
  
  RESULTS
  The clinical or pathological stage ware a localized cancer in 36 patients (27.3%), locally advanced cancer in 31 (23.5%), and metastatic cancer in 65 (49.2%). We detected increased β-catenin, AR, and MMP-7 expression with a high Gleason grade, disease progression, and increasing serum prostate-specific antigen (PSA) levels (p<0.01). In Spearman's rank correlations, the expression of cytoplasmic β-catenin, MMP-7, and the AR were found to be significantly positively correlated. In addition, the expression of β-catenin, MMP-7, and the AR were significantly correlated with clinicopathological variables indicative of a poor prognosis. Forty-nine patients with primary androgen deprivation had short response durations from hormone therapy to PSA progression with elevated MMP-7 expression on the Kaplan-Meier curve (p=0.0036).
  
  
  CONCLUSIONS
  These data show that an activated Wnt/β-catenin pathway and AR expression in prostate cancer are correlated with metastasis and aggressiveness. In addition, the expression of MMP-7 protein, a target of the Wnt/β-catenin pathway, is associated with PSA progression in prostate cancer patients undergoing primary hormone therapy.
authors: Department of Pathology, Inje University College of Medicine, Busan, Korea.
authors: Soo Jin
authors: SJ
authors: Jung
authors: Sangtaek
authors: S
authors: Oh
authors: Geun Taek
authors: GT
authors: Lee
authors: Jaeil
authors: J
authors: Chung
authors: Kweonsik
authors: K
authors: Min
authors: Jangho
authors: J
authors: Yoon
authors: Wansuk
authors: W
authors: Kim
authors: Dong Soo
authors: DS
authors: Ryu
authors: Isaac Yi
authors: IY
authors: Kim
authors: Dong Il
authors: DI
authors: Kang
keywords: Beta catenin; Matrix metalloproteinases; Prognosis; Prostate neoplasms; Receptors, androgen
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