title: Sensing of carboxylate drugs in urine by a supramolecular sensor array.
abstract: A supramolecular sensor array consisting of eight chemosensors embedded in a hydrogel matrix was used to sense carboxylate drugs. The discriminatory power of the array has been evaluated using principal component analysis and linear discriminant analysis. The eight-member sensor array has been shown to accurately identify 14 carboxylates in water with 100% classification accuracy. To demonstrate the potential for practical utility in the physiological environment, analysis of carboxylate drugs in human urine was also performed achieving 100% correct classification. In addition, the array performance in semiquantitative identification of nonsteroidal anti-inflammatory drugs has been investigated, and the results show that the sensor array is able to differentiate six typical nonsteroidal anti-inflammatory drugs at concentrations of 0.5-100 ppm. This illustrates the potential utility of the designed sensor array for diagnostic and environmental monitoring applications.
authors: Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA.
authors: Yuanli
authors: Y
authors: Liu
authors: Tsuyoshi
authors: T
authors: Minami
authors: Ryuhei
authors: R
authors: Nishiyabu
authors: Zhuo
authors: Z
authors: Wang
authors: Pavel
authors: P
authors: Anzenbacher
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000652:urine*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D015394:Molecular Structure; D012680:Sensitivity and Specificity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005456:Fluorescent Dyes; D020100:Hydrogels