title: The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.
abstract: Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of tumours carry activating mutations in GNAS (encoding Gαs), and that oncogenic activating mutations in genes encoding Gαq family members (GNAQ or GNA11) are present in ~66% and ~6% of melanomas arising in the eye and skin, respectively. Furthermore, nearly 20% of human tumours harbour mutations in GPCRs. Many human cancer-associated viruses also express constitutively active viral GPCRs. These studies indicate that G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment.
authors: Oral and Pharyngeal Cancer Branch, Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
authors: Morgan
authors: M
authors: O'Hayre
authors: José
authors: J
authors: Vázquez-Prado
authors: Irina
authors: I
authors: Kufareva
authors: Eric W
authors: EW
authors: Stawiski
authors: Tracy M
authors: TM
authors: Handel
authors: Somasekar
authors: S
authors: Seshagiri
authors: J Silvio
authors: JS
authors: Gutkind
mesh_terms: D000818:Animals; D015870:Gene Expression; D005787:Gene Frequency; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D043562:Receptors, G-Protein-Coupled; D020962:Heterotrimeric GTP-Binding Proteins
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