title: Perennial is more effective than preseasonal subcutaneous immunotherapy in the treatment of seasonal allergic rhinoconjunctivitis.
abstract: BACKGROUND
  Two different regimens of subcutaneous immunotherapy (IT), perennial or preseasonal, may be used in the treatment of seasonal allergy. The aim of this study was to compare the efficacy and safety of perennial IT (PIT) and preseasonal IT (PSIT) in patients suffering from seasonal rhinoconjunctivitis.
  
  
  METHODS
  The study was planned as a randomized, double-blind, comparative study on the efficacy and safety of PIT and PSIT. The study group comprised 120 patients allergic to grass and rye pollen. After the observational season they were randomized to receive PIT or PSIT for 3 years. The effect of IT was assessed based on symptom severity and medication use recorded in diaries.
  
  
  RESULTS
  Ninety-nine patients completed the study. No difference was seen between the groups regarding combined symptom medication score (SMS) in the first season of IT. During the second season, the difference between PIT and PSIT regarding combined SMS was 27.9% (p = 0.063) and reached 42.7% (p = 0.012) in favor of PIT in the third season. Both treatments had a similar safety profile.
  
  
  CONCLUSIONS
  PIT was more effective than PSIT in the treatment of rhinoconjunctivitis in patients allergic to grass and rye pollens.
authors: Divisiont of Internal Diseases, Asthma and Allergy, Barlicki University Hospital, Lodz, Poland. damian.tworek@gmail.com
authors: Damian
authors: D
authors: Tworek
authors: Malgorzata
authors: M
authors: Bochenska-Marciniak
authors: Izabela
authors: I
authors: Kuprys-Lipinska
authors: Maciej
authors: M
authors: Kupczyk
authors: Piotr
authors: P
authors: Kuna
mesh_terms: D000293:Adolescent; D000328:Adult; D003233:Conjunctivitis, Allergic / Q000276:immunology / Q000628:therapy*; D003888:Desensitization, Immunologic / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000187:drug effects; D007167:Immunotherapy / Q000379:methods; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage* / Q000276:immunology; D006109:Poaceae / Q000276:immunology; D011058:Pollen / Q000276:immunology; D011446:Prospective Studies; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*; D012621:Seasons; D012882:Skin Tests; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts; D007073:Immunoglobulin E
references: Allergy. 2011 Jun;66(6):725-32
references: 21466562
references: J Allergy Clin Immunol. 2005 Sep;116(3):608-13
references: 16159631
references: J Allergy Clin Immunol. 1991 Jul;88(1):27-32
references: 2071783
references: Allergy. 2007 Mar;62(3):317-24
references: 17298350
references: J Allergy Clin Immunol. 2006 Feb;117(2):319-25
references: 16461133
references: Allergy. 2006 Feb;61(2):198-201
references: 16409196
references: Clin Exp Allergy. 2001 Sep;31(9):1392-7
references: 11591189
references: J Allergy Clin Immunol. 2002 Feb;109(2):251-6
references: 11842293
references: Allergy. 1995 May;50(5):405-13
references: 7573829
references: Allergy. 2011 Oct;66(10):1345-59
references: 21707645
references: Allergy. 2006;61 Suppl 82:1-20
references: 16930249
references: Allergy. 2002 Apr;57(4):306-12
references: 11906360
references: Allergy Asthma Proc. 2012 Mar-Apr;33(2):122-8
references: 22525388
references: Am J Rhinol Allergy. 2012 Nov-Dec;26(6):469-74
references: 23232197
references: Ann Allergy Asthma Immunol. 2005 Apr;94(4):451-6
references: 15875526