title: Triterpene saponins of Genista ulicina Spach.
abstract: From the n-BuOH extract of the aerial parts of Genista ulicina, six triterpene saponins, 3-O-β-D-glucopyranosyl-olean-12-ene-3β,27,28,30-tetraol, 3-O-β-D-glucopyranosyl-olean-12-ene-3β,27,28,29-tetraol, 3,29-di-O-β-D-glucopyranosyl-olean-12-ene-3β,27,28,29-tetraol, 3-O-β-D-glucopyranosyl-olean-12-ene-3β,28,29-triol-27-oic acid, 3-O-β-D-glucopyranosyl-olean-12-ene-3β,27,28-triol-29-oic acid, and 3-O-β-D-glucopyranosyl-14-H-27-nor-olean-12-ene-3β,28,29-triol, were isolated together with eight known triterpene saponins and six flavonoids. Their structures were established mainly by means of spectroscopic methods (1D and 2D-NMR as well as HR-ESI-MS). The n-BuOH extract, investigated for its antitumor growth inhibition of human colon cancer HT-29 cells, presented no significant activity (IC50>100 μg).
authors: Institut de Chimie Moléculaire de Reims (ICMR), CNRS UMR 7312, UFR de Pharmacie, BP 1039, 51687 Reims, France.
authors: Naima
authors: N
authors: Boutaghane
authors: Laurence
authors: L
authors: Voutquenne-Nazabadioko
authors: Dominique
authors: D
authors: Harakat
authors: Alain
authors: A
authors: Simon
authors: Zahia
authors: Z
authors: Kabouche
mesh_terms: D049109:Cell Proliferation; D039761:Genista / Q000737:chemistry*; D019073:HT29 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes
keywords: BJJGORZQELYRDI-KNSQHGMUSA-N; BJJGORZQELYRDI-VROOZBDDSA-N; Cytotoxic activity; Fabaceae; Genista ulicina; HFHHGAGIYCPWEJ-KEKGXROISA-N; MMOWNTHMMVQHSI-POVYRCDXSA-N; Triterpenoid saponins; UTZJXWSFXGRIHE-XHNVEASOSA-N; VUBHEJPEVMGDCH-DNVPAQNPSA-N