title: Altered expression of RNA splicing proteins in Alzheimer's disease patients: evidence from two microarray studies.
abstract: OBJECTIVE
  Dysregulation of pre-mRNA splicing from an altered expression of RNA splice-regulatory proteins may act as the convergence point underlying aberrant gene expression changes in Alzheimer's disease (AD).
  
  
  METHODS
  Two microarray datasets from a control/AD postmortem brain cohort of 31 subjects - 9 controls and 22 AD subjects (National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database) - were used.
  
  
  RESULTS
  Between the two microarray studies, the expression of six splice-regulatory protein genes showed concordant changes in AD. These genes were then correlated with gene expression changes of transcripts reported to be altered in AD. Amyloid beta (A4) precursor protein and tropomyosin receptor kinase B transcripts were found to correlate significantly with the same splice-regulatory proteins in the two studies.
  
  
  CONCLUSIONS
  This study highlights a susceptibility network that can potentially link a number of susceptibility genes.
authors: Illawarra Health and Medical Research Institute, and School of Biological Sciences, University of Wollongong, Wollongong, N.S.W., Australia.
authors: Jenny
authors: J
authors: Wong
keywords: Alternative splicing; Alzheimer's disease; Brain tissue, postmortem; Gene expression; Hippocampus; Microarray
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