title: Synthesis of new conjugated coumarin-benzimidazole hybrids and their anticancer activity.
abstract: A series of novel coumarin-benzimidazole hybrids, 3-(1H-benzo[d]imidazol-2-yl)-7-(substituted amino)-2H-chromen-2-one derivatives of biological interest were synthesized. Six out of the newly synthesized compounds were screened for in vitro antitumor activity against preliminary 60 tumor cell lines panel assay. A significant inhibition for cancer cells was observed with compound 8 (more than 50% inhibition) compared with other compounds and active known drug 5-fluorouracil (in some cell lines) as positive control. Compound 8 displayed appreciable anticancer activities against leukemia, colon cancer and breast cancer cell lines.
authors: School of Chemistry and Biochemistry, Thapar University, Patiala 147004, India. kpaul@thapar.edu
authors: Kamaldeep
authors: K
authors: Paul
authors: Shweta
authors: S
authors: Bindal
authors: Vijay
authors: V
authors: Luxami
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D062105:Molecular Docking Simulation
chemical_list: D000970:Antineoplastic Agents; D001562:Benzimidazoles; D003374:Coumarins