title: Neuregulin 3 and erbb signalling networks in embryonic mammary gland development.
abstract: We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have shown that Nrg3 expression profoundly impacts early stages of embryonic mammary development. Network analysis shows how Nrg/Erbb signals could integrate with other major regulators of embryonic mammary development to elicit the morphogenetic processes and cell fate decisions that occur as the mammary lineage is established.
authors: Division of Breast Cancer Research, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK.
authors: Naoko
authors: N
authors: Kogata
authors: Marketa
authors: M
authors: Zvelebil
authors: Beatrice A
authors: BA
authors: Howard
mesh_terms: D000818:Animals; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008321:Mammary Glands, Animal / Q000196:embryology* / Q000378:metabolism*; D042361:Mammary Glands, Human / Q000196:embryology* / Q000378:metabolism*; D020880:Neuregulins / Q000235:genetics / Q000378:metabolism*; D018739:Oncogene Proteins v-erbB / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D020880:Neuregulins; D018739:Oncogene Proteins v-erbB
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