title: Asymmetric Mannich reaction of α-keto imines catalyzed by diarylprolinol silyl ether.
abstract: Synthetic methods: An asymmetric catalytic, desulfonylative Mannich reaction of α-keto imines with aldehydes, as catalyzed by diarylprolinol silyl ether 1, was developed. It gave the Mannich product in good yield with excellent anti and enantioselectivity (see scheme; Boc = tert-butoxycarbonyl, TMS = trimethylsilyl).
authors: Department of Chemistry, Graduate School of Science, Tohoku University, 6-3 Aramaki-Aza Aoba, Aoba-ku, Sendai 980-8578, Japan. yhayashi@m.tohoku.ac.jp
authors: Yujiro
authors: Y
authors: Hayashi
authors: Daisuke
authors: D
authors: Sakamoto
authors: Hiroki
authors: H
authors: Shomura
authors: Daisuke
authors: D
authors: Hashizume