title: Adipokines and endothelial dysfunction in obesity WHO°III.
abstract: Obesity is closely associated with the metabolic syndrome (MetS) and subsequent low-grade inflammation links to endothelial dysfunction (ED) and cardiovascular disease. The impact of adipokines on retinal ED is not fully understood, in particular not in severe obesity. The aim of the study was to identify the association of the MetS and prespecified adipokines on retinal ED in obesity WHO°III. 92 obese patients (obesity WHO°III) were assessed for the MetS (IDF), neck circumference, adipokines and inflammatory markers (hsCRP, TNFα, Il-6, MCP-1, sICAM, sVCAM, IGF-BP3, RBP 4 and adiponectin). Retinal ED as determined by the arterio-venous-ratio (AVR) and retinal vessel diameters (CRAE, CRVE) was measured using retinal photographs. Obese subjects with MetS (MetS+ group) differed from the MetS- by neck circumference, fasting plasma glucose, insulin, HOMA-IR, triglycerides and HDL-C. Importantly, IL-6, sICAM and adiponectin were significantly different between groups, while measures of retinal ED showed no differences. Univariate linear regression revealed a significant association between neck circumference and ED for patients with MetS, and a significant association between adiponectin and CRAE for patients without MetS. This study shows that ED in obesity WHO°III is independent of MetS or inflammation and that neck circumference has an impact on ED in obesity WHO°III.
authors: Universitätsmedizin Mannheim, 5th Medical Department, University of Heidelberg, Germany.
authors: Christine
authors: C
authors: Bachmayer
authors: Anne
authors: A
authors: Kemmer
authors: Nadine
authors: N
authors: Ehrmann
authors: Till
authors: T
authors: Hasenberg
authors: Alexander
authors: A
authors: Lammert
authors: Hans-Peter
authors: HP
authors: Hammes
mesh_terms: D054392:Adipokines / Q000097:blood / Q000378:metabolism*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D001160:Arterioles / Q000473:pathology; D001835:Body Weight; D004730:Endothelium, Vascular / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D008875:Middle Aged; D009765:Obesity; D012044:Regression Analysis; D012160:Retina / Q000473:pathology*
chemical_list: D054392:Adipokines; D052242:Adiponectin
keywords: AVR; Arterio-venous-ratio; CRAE; CRVE; Central retinal artery equivalent; Central retinal vein equivalent; ED; Endothelial dysfunction; High sensitive CRP; IGF-BP 3; IL-6; Insulin like growth factor binding protein 3; Interleukin 6; MCP-1; MOS; Mannheim Obesity Study; MetS; Metabolic syndrome; Monocyte chemotactic protein 1; RBP4; Retinol binding protein 4; Soluble intercellular adhesion molecule; Soluble vascular cell adhesion molecule; TNFα; Tumor necrosis factor alpha; hsCRP; sICAM; sVCAM