title: Neural networks to identify multiple sclerosis with optical coherence tomography.
abstract: OBJECTIVE
  To compare axonal loss in ganglion cells detected with spectral-domain optical coherence tomography (OCT) in eyes of patients with multiple sclerosis (MS) versus healthy control subjects using an artificial neural network (ANN). To analyse the capability of the ANN technique to improve the detection of retinal nerve fibre layer (RNFL) damage in patients with multiple sclerosis.
  
  
  METHODS
  Patients with multiple sclerosis (n = 106) and age-matched healthy subjects (n = 115) were enrolled. The Spectralis OCT system was used to obtain the circumpapillary RNFL thickness in both eyes. The 768 RNFL thickness measurements provided by the Spectralis OCT were performed to obtain thickness measurements from 24 uniformly divided locations around the peripapillary RNFL. The performance of the ANN technique for identifying RNFL loss in patients with multiple sclerosis was evaluated. Receiver-operating characteristic (ROC) curves were used to display the ability of the test to discriminate between MS and healthy eyes in our population. ROC curves obtained using ANN and parameters provided by OCT (mean and 6 sector thicknesses) were compared.
  
  
  RESULTS
  The capability of the ANN technique to detect RNFL loss in patients with multiple sclerosis compared with healthy subjects was good. The area under the ROC curve was 0.945. Compared with the OCT-provided parameters, the ANN had the largest area under the ROC curve.
  
  
  CONCLUSIONS
  Measurements of RNFL thickness obtained with Spectralis OCT have a good ability to differentiate between healthy and individuals with multiple sclerosis. Based on the area under the ROC curve, the ANN performed better than any single OCT parameter.
authors: Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, SpainAragones Institute of Health Science, Zaragoza, SpainNeurology Department, Miguel Servet University Hospital, Zaragoza, SpainOphthalmology Department, Clinico San Carlos University Hospital, Madrid, Spain.
authors: Elena
authors: E
authors: Garcia-Martin
authors: Luis E
authors: LE
authors: Pablo
authors: Raquel
authors: R
authors: Herrero
authors: Jose R
authors: JR
authors: Ara
authors: Jesus
authors: J
authors: Martin
authors: Jose M
authors: JM
authors: Larrosa
authors: Vicente
authors: V
authors: Polo
authors: Julian
authors: J
authors: Garcia-Feijoo
authors: Javier
authors: J
authors: Fernandez
mesh_terms: D000328:Adult; D000368:Aged; D001369:Axons / Q000473:pathology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis*; D016571:Neural Networks, Computer; D009898:Optic Disk / Q000473:pathology*; D012372:ROC Curve; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D014065:Tonometry, Ocular; D055815:Young Adult
keywords: multiple sclerosis; neural networks; optical coherence tomography; retinal nerve fibre layer