title: Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukopenia in mice.
abstract: The aim of the study is to investigate the effect of recombinant Ganoderma lucidum immunoregulatory protein (rLZ-8) on mouse models of cyclophosphamide-induced leukopenia, which we have established with both single-phase and multi-phase administration methods. Treatment with rLZ-8 had a strong effect on both models of cyclophosphamide-induced leukopenia. In particular, it increased the number of neutrophils, lymphocytes and monocytes. rLZ-8 treatment also increased the percentage of CD4(+) T cells and the levels of secreted IL-3 and IL-4, which contributed to the cyclophosphamide-induced immune dysfunction and immune system imbalance. In conclusion, rLZ-8 treatment benefitted mice with cyclophosphamide-induced leukopenia by improving overall immune function and by specifically increasing the number of white blood cells.
authors: Institute of Frontier Medical Science of Jilin University, Changchun, P.R. China.
authors: Hui
authors: H
authors: Zhou
authors: Fei
authors: F
authors: Sun
authors: Hongrui
authors: H
authors: Li
authors: Shuqin
authors: S
authors: Zhang
authors: Zhiyi
authors: Z
authors: Liu
authors: Jin
authors: J
authors: Pei
authors: Chongyang
authors: C
authors: Liang
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000009:adverse effects*; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D005656:Fungal Proteins / Q000008:administration & dosage / Q000235:genetics / Q000627:therapeutic use*; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology; D007970:Leukopenia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D020940:Reishi / Q000737:chemistry*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D016207:Cytokines; D005656:Fungal Proteins; C061148:LZ-8 protein, Ganoderma lucidum; D003520:Cyclophosphamide