title: Effect of the administration of Solanum nigrum fruit on blood glucose, lipid profiles, and sensitivity of the vascular mesenteric bed to phenylephrine in streptozotocin-induced diabetic rats.
abstract: BACKGROUND
  Solanum nigrum fruit is traditionally used in Asia to manage, control, and treat diabetes but there is no scientific evidence of the efficacy of Solanum nigrum fruit in treatment of diabetes. We designed this study to investigate the effect of the administration of oral doses of aqueous extract from Solanum nigrum fruit on plasma glucose, lipid profiles, and the sensitivity of the vascular mesenteric bed to Phenylephrine in diabetic and non-diabetic rats.
  
  
  METHODS
  Animals were divided into 5 groups (n=10): 2 groups served as non-diabetic controls (NDC), and the other groups had diabetes induced with a single injection of streptozotocin (STZ). Solanum nigrum-treated chronic diabetic (CD-SNE) and Solanum nigrum-treated controls (ND-SNE) received 1g/l of Solanum nigrum added to drinking water for 8 weeks. The mesenteric vascular beds were prepared using the McGregor method.
  
  
  RESULTS
  Administration of Solanum nigrum caused Ca/Mg ratio, plasma glucose, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), total cholesterol, and triglyceride concentrations to return to normal levels, and was shown to decrease alteration in vascular reactivity to vasoconstrictor agents.
  
  
  CONCLUSIONS
  Our results support the hypothesis that Solanum nigrum could play a role in the management of diabetes and the prevention of vascular complications in STZ-induced diabetic rats.
authors: Department of Physiology, School of Medicine and Research Center for Molecular Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
authors: Shahla
authors: S
authors: Sohrabipour
authors: Fatemah
authors: F
authors: Kharazmi
authors: Nepton
authors: N
authors: Soltani
authors: Mohammad
authors: M
authors: Kamalinejad
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry; D005951:Glucose Tolerance Test; D008055:Lipids / Q000097:blood*; D008274:Magnesium / Q000097:blood; D008297:Male; D008643:Mesentery / Q000098:blood supply* / Q000187:drug effects; D010477:Perfusion; D010656:Phenylephrine / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D032324:Solanum nigrum / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D008055:Lipids; D010936:Plant Extracts; D010656:Phenylephrine; D008274:Magnesium; D002118:Calcium
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