title: Molecular motors and apical CFTR traffic in epithelia.
abstract: Intracellular protein traffic plays an important role in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channels. Microtubule and actin-based motor proteins direct CFTR movement along trafficking pathways. As shown for other regulatory proteins such as adaptors, the involvement of protein motors in CFTR traffic is cell-type specific. Understanding motor specificity provides insight into the biology of the channel and opens opportunity for discovery of organ-specific drug targets for treating CFTR-mediated diseases.
authors: Department of Pediatrics/Gastroenterology & Hepatology, School of Medicine, Yale University, New Haven, CT 06520, USA. nadia.ameen@yale.edu.
authors: Dmitri V
authors: DV
authors: Kravtsov
authors: Nadia A
authors: NA
authors: Ameen
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000032:analysis / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism*; D021381:Protein Transport
chemical_list: D000199:Actins; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D009218:Myosins
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