title: Circulating secreted frizzled-related protein 5 (Sfrp5) and wingless-type MMTV integration site family member 5a (Wnt5a) levels in patients with type 2 diabetes mellitus.
abstract: BACKGROUND
  Secreted frizzled-related protein 5 (Sfrp5), an endogenous inhibitor of wingless-type MMTV integration site family (Wnt) signalling, is an anti-inflammatory adipokine whose expression is perturbed in models of obesity and type 2 diabetes mellitus (T2DM). Wnt member 5a (Wnt5a) is a representative ligand, and recent reports suggest that Wnt5a is involved in inflammatory diseases and metabolic disorders. The aim of this study was to investigate whether plasma Wnt5a and Sfrp5 levels are altered in patients with T2DM.
  
  
  METHODS
  Plasma Sfrp5 and Wnt5a concentrations were measured through enzyme-linked immunosorbent assay in type 2 diabetic and nondiabetic subjects.
  
  
  RESULTS
  A total of 82 patients with T2DM and 42 nondiabetic subjects were studied. Plasma Sfrp5 levels were found to be elevated in patients with T2DM (9.4 ± 9.0 vs 7.4 ± 10.9 ng/mL, p = 0.006). In contrast, Wnt5a levels were decreased (6.8 ± 12.6 vs 9.1 ± 4.0 ng/dL, p < 0.001). Increasing concentrations of Sfrp5 were independently and significantly associated with T2DM. Multiple logistic regression analysis revealed Sfrp5 as an independent association factor for T2DM, even after full adjustment of known biomarkers. In a multiple linear regression analysis, only the fasting glucose level was positively associated with the plasma Sfrp5 level.
  
  
  CONCLUSIONS
  Our results indicate that Sfrp5 may play a role in the pathogenesis of T2DM.
authors: Division of Endocrinology and Metabolism, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; Department of Medical Nutrition, Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan.
authors: Yung-Chuan
authors: YC
authors: Lu
authors: Chao-Ping
authors: CP
authors: Wang
authors: Chia-Chang
authors: CC
authors: Hsu
authors: Cheng-An
authors: CA
authors: Chiu
authors: Teng-Hung
authors: TH
authors: Yu
authors: Wei-Chin
authors: WC
authors: Hung
authors: Li-Fen
authors: LF
authors: Lu
authors: Fu-Mei
authors: FM
authors: Chung
authors: I-Ting
authors: IT
authors: Tsai
authors: Hsien-Chang
authors: HC
authors: Lin
authors: Yau-Jiunn
authors: YJ
authors: Lee
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D005136:Eye Proteins / Q000097:blood* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood* / Q000502:physiology; D008875:Middle Aged; D015999:Multivariate Analysis; D011518:Proto-Oncogene Proteins / Q000097:blood*; D051153:Wnt Proteins / Q000097:blood*; D000071818:Wnt-5a Protein; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D005136:Eye Proteins; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; C118511:SFRP5 protein, human; D000094742:Secreted Frizzled-Related Proteins; C085389:WNT5A protein, human
keywords: Wnt5a; anti-inflammatory; secreted frizzled-related protein 5; type 2 diabetes mellitus