title: An opportunistic infection associated with ruxolitinib, a novel janus kinase 1,2 inhibitor.
abstract: We report a case of Cryptococcus neoformans pneumonia in a patient taking ruxolitinib, a janus kinase 1,2 inhibitor approved for the treatment of myelofibrosis. We hypothesize that ruxolitinib contributed to this infection through its effects on cell-mediated immunity. Clinicians should be aware of the potential for intracellular or opportunistic infections associated with this novel drug class.
authors: Department of Internal Medicine, Oregon Health and Science University, Portland, OR.
authors: Nicholas G
authors: NG
authors: Wysham
authors: Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR.
authors: Donald R
authors: DR
authors: Sullivan
authors: Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR. Electronic address: alladag@ohsu.edu.
authors: Gopal
authors: G
authors: Allada
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D003453:Cryptococcosis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D003455:Cryptococcus neoformans; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D053613:Janus Kinase 1 / Q000037:antagonists & inhibitors*; D053614:Janus Kinase 2 / Q000037:antagonists & inhibitors*; D008168:Lung / Q000000981:diagnostic imaging / Q000382:microbiology; D008297:Male; D009570:Nitriles; D009894:Opportunistic Infections / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D018410:Pneumonia, Bacterial / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D055728:Primary Myelofibrosis / Q000188:drug therapy / Q000276:immunology; D011720:Pyrazoles / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D011743:Pyrimidines; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D009570:Nitriles; D011720:Pyrazoles; D011743:Pyrimidines; C540383:ruxolitinib; D015725:Fluconazole; D053613:Janus Kinase 1; D053614:Janus Kinase 2
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