title: Neurovascular factors in resting-state functional MRI.
abstract: There has been growing interest in the use of resting-state functional magnetic resonance imaging (rsfMRI) for the assessment of disease and treatment, and a number of studies have reported significant disease-related changes in resting-state blood oxygenation level dependent (BOLD) signal amplitude and functional connectivity. rsfMRI is particularly suitable for clinical applications because the approach does not require the patient to perform a task and scans can be obtained in a relatively short amount of time. However, the mechanisms underlying resting-state BOLD activity are not well understood and thus the interpretation of changes in resting state activity is not always straightforward. The BOLD signal represents the hemodynamic response to neural activity, and changes in resting-state activity can reflect a complex combination of neural, vascular, and metabolic factors. This paper examines the role of neurovascular factors in rsfMRI and reviews approaches for the interpretation and analysis of resting state measures in the presence of confounding factors.
authors: Center for Functional Magnetic Resonance Imaging, University of California San Diego, 9500 Gilman Drive, MC 0677, La Jolla, CA 92093-0677, USA. ttliu@ucsd.edu
authors: Thomas T
authors: TT
authors: Liu
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D063132:Connectome / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008953:Models, Anatomic; D008959:Models, Neurological; D009415:Nerve Net / Q000098:blood supply / Q000502:physiology*; D010100:Oxygen / Q000097:blood*; D012146:Rest / Q000502:physiology
chemical_list: D010100:Oxygen
keywords: BOLD; Functional connectivity; Neurovascular coupling; fMRI
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