title: Nasal symptoms and clinical findings in adult patients treated for unilateral cleft lip and palate.
abstract: The aim of the study was to investigate self-experienced nasal symptoms among adults treated for UCLP and the association to clinical findings, and to evaluate whether palate closure in one-stage or two-stages affected the symptoms or clinical findings. All people with UCLP born between 1960-1987, treated at Uppsala University Hospital, were considered for participation in this cross-sectional population study with long-term follow-up. Eighty-three patients (76% participation rate) participated, a mean of 37 years after the first operation. Fifty-two patients were treated with one-stage palate closure and 31 with two-stage palate closure. An age-matched group of 67 non-cleft controls completed the same study protocol, which included a questionnaire regarding nasal symptoms, nasal inspection, anterior rhinoscopy, and nasal endoscopy. Patients reported a higher frequency of nasal symptoms compared with the control group, e.g., nasal obstruction (81% compared with 60%) and mouth breathing (20% compared with 5%). Patients also rated their nasal symptoms as having a more negative impact on their daily life and physical activities than controls. Nasal examination revealed higher frequencies of nasal deformities among patients. No positive correlation was found between nasal symptoms and severity of findings at nasal examination. No differences were identified between patients treated with one-stage and two-stage palate closure regarding symptoms or nasal findings. Adult patients treated for UCLP suffer from more nasal symptoms than controls. However, symptoms are not associated with findings at clinical nasal examination or method of palate closure.
authors: Section of Otorhinolaryngology.
authors: Staffan
authors: S
authors: Morén
authors: Maria
authors: M
authors: Mani
authors: Kristina
authors: K
authors: Lundberg
authors: Mats
authors: M
authors: Holmström
mesh_terms: D000328:Adult; D002971:Cleft Lip / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D002972:Cleft Palate / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000503:physiopathology; D009297:Nasal Mucosa / Q000503:physiopathology; D015508:Nasal Obstruction / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D009667:Nose Deformities, Acquired / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D011788:Quality of Life; D019651:Plastic Surgery Procedures / Q000009:adverse effects* / Q000379:methods; D012016:Reference Values; D012189:Retrospective Studies; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D013548:Sweden; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult