title: A differential pattern of gene expression in skeletal muscle of tumor-bearing rats reveals dysregulation of excitation–contraction coupling together with additional muscle alterations.
abstract: BACKGROUND
  Cachexia is a wasting condition that manifests in several types of cancer. The main characteristic of this condition is a profound loss of muscle mass.
  
  
  METHODS
  By using a microarray system, expression of several hundred genes was screened in skeletal muscle of rats bearing a cachexia-inducing tumor, the AH-130 Yoshida ascites hepatoma. This model induced a strong decrease in muscle mass in the tumor-bearing animals, as compared with their healthy counterparts.
  
  
  RESULTS
  The results show important differences in gene expression in EDL skeletal muscle between tumor-bearing animals with cachexia and control animals.
  
  
  CONCLUSIONS
  The differences observed pertain to genes related to intracellular calcium homeostasis and genes involved in the control of mitochondrial oxidative phosphorylation and protein turnover, both at the level of protein synthesis and proteolysis. Assessment of these differences may be a useful tool for the design of novel therapeutic strategies to fight this devastating syndrome.
authors: Cibely Cristine
authors: CC
authors: Fontes-Oliveira
authors: Sílvia
authors: S
authors: Busquets
authors: Gemma
authors: G
authors: Fuster
authors: Elisabet
authors: E
authors: Ametller
authors: Maite
authors: M
authors: Figueras
authors: Mireia
authors: M
authors: Olivan
authors: Míriam
authors: M
authors: Toledo
authors: Francisco J
authors: FJ
authors: López-Soriano
authors: Xiaoyan
authors: X
authors: Qu
authors: Jeffrey
authors: J
authors: Demuth
authors: Paula
authors: P
authors: Stevens
authors: Alex
authors: A
authors: Varbanov
authors: Feng
authors: F
authors: Wang
authors: Robert J
authors: RJ
authors: Isfort
authors: Josep M
authors: JM
authors: Argilés
mesh_terms: D000818:Animals; D002100:Cachexia / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000502:physiology; D056966:Excitation Contraction Coupling / Q000235:genetics / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D008113:Liver Neoplasms / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D018482:Muscle, Skeletal / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002118:Calcium