title: The effect of ultraviolet radiation on the anti-inflammatory effect of filters.
abstract: A certain number of filters have notable anti-inflammatory properties with percentage inhibition of PMA-induced edema in mice at over 70%. The question arose as to whether this effect was likely to continue after UV irradiation. It can be noted that 7 filters retain an equivalent anti-inflammatory effect before and after 2h of irradiation in a Suntest device (650 W/m(2)). For 9 filters, the anti-inflammatory effect decreases and for 5 filters, the anti-inflammatory effect increases. Various behaviors should be noted. 3 groups of substances can be distinguished: such as phenylbenzimidazole sulfonic acid which loses its anti-inflammatory character after irradiation (the percentage inhibition falls from 80 to 44%), oxybenzone which retains a constant anti-inflammatory character (89% inhibition before and after irradiation and also octyl methoxycinnamate which becomes very anti-inflammatory (with a percentage inhibition of 93%). The same phenomenon is observed in the case of commercial products. This should be made known as it can have a considerable impact on the results which are displayed on the packaging of sun products.
authors: Université de Nantes, Nantes Atlantique Universités, GEP3, MMS, EA 2160, Faculty of Pharmacy, 9 rue Bias, Nantes, F-44000, France.
authors: C
authors: C
authors: Couteau
authors: O
authors: O
authors: Couteau
authors: C
authors: C
authors: Chauvet
authors: E
authors: E
authors: Paparis
authors: L J M
authors: LJ
authors: Coiffard
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000528:radiation effects*; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004655:Emulsions; D008297:Male; D051379:Mice; D013473:Sunscreening Agents / Q000008:administration & dosage* / Q000528:radiation effects*; D013755:Tetradecanoylphorbol Acetate; D014466:Ultraviolet Rays; D015034:Zinc Oxide / Q000008:administration & dosage / Q000528:radiation effects
chemical_list: D000893:Anti-Inflammatory Agents; D004655:Emulsions; D013473:Sunscreening Agents; D013755:Tetradecanoylphorbol Acetate; D015034:Zinc Oxide