title: Correlations between concentrations of interleukin (IL)-17A, IL-17B and IL-17F, and endothelial cells and proangiogenic cytokines in systemic lupus erythematosus patients.
abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease of multifactorial pathoaetiology. Different organs and blood vessels may be affected by chronic inflammation. A direct cause of the disease has not yet been found, so research is being carried out to this effect. The role of the recently identified helper T lymphocyte CD4+, described as Th17, and its dependent cytokines have been of particular interest. The aim of the study was to evaluate IL-17A, IL-17B, IL-17F and IL-23 in 60 SLE patients and 26 age-matched, healthy volunteers and also to investigate the correlation between levels of the investigated cytokines and VEGF, PIGF, as well as number of endothelial cells. IL-17A, IL-17B, IL-17BR and IL-17F levels were found to be higher in SLE patients than in the control group. However, only IL-17F levels showed a statistically significant correlation with the number of endothelial cells (aCEC) and disease activity. Correlations between levels of IL-17F and VEGF and PIGF as well as VEGF and IL-17A and IL-23 were statistically significant. Increased levels of the selected cytokines from the IL-17 family in SLE patients suggest a role for them not only in the inflammatory process but also in angiogenesis. This also highlights the role of IL-17F in activating vascular endothelial cells and consequently blood vessel formation, and in the relationship between the inflammatory reaction and angiogenesis in the development of SLE.
authors: Department of Dermatology and Venereology, Medical University of Lodz, Poland. ewarobak@onet.eu
authors: Ewa
authors: E
authors: Robak
authors: Lilianna
authors: L
authors: Kulczycka-Siennicka
authors: Zofia
authors: Z
authors: Gerlicz
authors: Monika
authors: M
authors: Kierstan
authors: Anna
authors: A
authors: Korycka-Wolowiec
authors: Anna
authors: A
authors: Sysa-Jedrzejowska
mesh_terms: D000328:Adult; D043925:Angiogenesis Inducing Agents / Q000097:blood*; D016022:Case-Control Studies; D042783:Endothelial Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D053759:Interleukin-23 / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D055815:Young Adult
chemical_list: D043925:Angiogenesis Inducing Agents; D020381:Interleukin-17; D053759:Interleukin-23; D008565:Membrane Proteins; C098069:PIGF protein, human; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: IL-17A; IL-17B; IL-17F; SLE; circulating endothelial cells