title: Fabrication and characterization of photoluminescent silicon nanoparticles for drug delivery applications.
abstract: Photoluminescent silicon nanoparticles containing camptothecin (CPT) were fabricated by using a CPT-derivatized porous silicon (PSi). PSi samples displaying red photoluminescence (PL) were prepared by an electrochemical etch of n-type silicon under the illumination with a 300 W tungsten filament bulb for the duration of etch. For the drug-derivatized PSi, luminescent PSi was oxidized and derivatized with CPT. Silicon nanoparticles containing CPT were obtained by fracturing of luminescent PSi with ultrasono-method. Optical characteristic of drug-derivatized silicon particles were investigated in aqueous buffer solution. The release of CPT was measured by UV-vis spectrometer. The intensity of fluorescence of the silicon nanoparticles was measured with a drug release. The concentration of released drug exhibited non-linear relationship with a release time.
authors: Department of Chemistry, Chosun University, Gwangju 501-759, Korea.
authors: Jeongkwan
authors: J
authors: Ryu
authors: Bomin
authors: B
authors: Cho
authors: Hee-Gweon
authors: HG
authors: Woo
authors: Sungdong
authors: S
authors: Cho
authors: Honglae
authors: H
authors: Sohn
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry; D002166:Camptothecin / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000528:radiation effects; D004058:Diffusion / Q000528:radiation effects; D008027:Light; D008163:Luminescent Measurements / Q000379:methods*; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure*; D010316:Particle Size; D012825:Silicon / Q000737:chemistry* / Q000528:radiation effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D002166:Camptothecin; D012825:Silicon