title: STUDY OF THE NEAR INFRARED-MEDIATED HEATING OF DISPERSIONS OF PROTEIN-COATED PRISTINE AND CARBOXYLATED SINGLE-WALLED CARBON NANOTUBES.
abstract: Previously, we demonstrated the selective NIR-mediated ablation of tumor cellsin vitrousing pristine single-walled carbon nanotubes (SWNTs) with adsorbed tumor-targeting ligands and carboxylated SWNTs with covalently-attached ligands. The covalent approach is advantageous in ensuring that protein ligands remain associated with the NIR-absorbing SWNTs in biological matrices and the noncovalent approach has the advantage of enabling SWNT functionalization without perturbation of the SWNT lattice and photothermal properties. Herein, we compare the ability of moderately-carboxylated (~4 at.% carboxylic acid groups) and pristine SWNT materials to absorb 808 nm radiation and convert it to heat. Under conditions of a constant 808 nm laser power density, the approach involved measuring the temperature of aqueous dispersions of protein-coated SWNTs as a function of the irradiation time. Nearly identical temperature profiles were observed for dispersions of moderately-carboxylated and pristine SWNTs possessing matched 808 nm optical densities and equivalent concentrations of carbonaceous species (i.e., SWNTs and amorphous carbon impurities). The results indicate that the amount of carbonaceous species in purified dispersions of protein-coated SWNTs is more important for converting absorbed 808 nm radiation into heat than whether or not the SWNTs were moderately carboxylated, and that moderately-carboxylated SWNTs could be the SWNT-material of choice for the targeted photothermal ablation of tumor cells.
authors: Department of Chemistry, The University of Texas at Dallas, Richardson, TX 75080-3021, USA.
authors: Alex T
authors: AT
authors: Sheardy
authors: Jeremy J
authors: JJ
authors: Taylor
authors: Jennifer L
authors: JL
authors: Chilek
authors: Synyoung
authors: S
authors: Li
authors: Ruhung
authors: R
authors: Wang
authors: Rockford K
authors: RK
authors: Draper
authors: Paul
authors: P
authors: Pantano
keywords: Photothermal therapy; nanoparticle-mediated hyperthermia; oxidized carbon nanotubes; tumor cell ablation
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