title: Study of the efficiency of doxorubicin deposited in microparticles from resorbable Bioplastotane™ on laboratory animals with Ehrlich's solid carcinoma.
abstract: Antitumor efficiency of an experimental form of an experimental form of anthracyclin antibiotic (doxorubicin), resorbable microparticles from Bioplastotane(TM), was studied on laboratory mice with transplanted Ehrlich's solid carcinoma. Use of the experimental form of the cytostatic in polymeric microparticles from resorbable Bioplastotane(TM)in animals with solid tumor led to inhibition of the cancerous process, comparable to that in response to intravenous free doxorubicin, but without negative effects on the blood system.
authors: Institute of Biophysics, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia.
authors: E I
authors: EI
authors: Shishatskaya
authors: A V
authors: AV
authors: Goreva
authors: A M
authors: AM
authors: Kuzmina
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D001672:Biocompatible Materials / Q000737:chemistry; D002214:Capsules / Q000737:chemistry*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D006885:Hydroxybutyrates / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000473:pathology; D009368:Neoplasm Transplantation; D011091:Polyesters / Q000737:chemistry*; D000094122:Polyhydroxybutyrates
chemical_list: D000903:Antibiotics, Antineoplastic; D001672:Biocompatible Materials; D002214:Capsules; D004317:Doxorubicin; D004337:Drug Carriers; D006885:Hydroxybutyrates; D011091:Polyesters; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates