title: Emerging roles of Cdk8 in cell cycle control.
abstract: Cyclin dependent kinase 8 (Cdk8) is a component of Mediator, an evolutionary conserved multiprotein complex that regulates RNA polymerase II-dependent transcription. Cdk8 has been implicated as a regulator of multiple steps in cell cycle progression. We here discuss recent advances in our understanding of Cdk8 function and a possible role for Mediator as a hub for integrating transcription regulation with cell cycle progression.
authors: Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Sweden. zsolt.szilagyi@medkem.gu.se
authors: Zsolt
authors: Z
authors: Szilagyi
authors: Claes M
authors: CM
authors: Gustafsson
mesh_terms: D002453:Cell Cycle / Q000502:physiology*; D056850:Cyclin-Dependent Kinase 8 / Q000502:physiology*; D012319:RNA Polymerase II / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*
chemical_list: D029701:Saccharomyces cerevisiae Proteins; D056850:Cyclin-Dependent Kinase 8; C498309:SSN3 protein, S cerevisiae; D012319:RNA Polymerase II
keywords: Differentiation; Mediator; Mitosis; Protein stability; Stem cells; Wnt/β-catenin signaling