title: Correlation between eight-gene expression profiling and response to therapy of newly diagnosed multiple myeloma patients treated with thalidomide-dexamethasone incorporated into double autologous transplantation.
abstract: We performed a molecular study aimed at identifying a gene expression profile (GEP) signature predictive of attainment of at least near complete response (CR) to thalidomide-dexamethasone (TD) as induction regimen in preparation for double autologous stem cell transplantation in 112 younger patients with newly diagnosed multiple myeloma. A GEP supervised analysis was performed on a training set of 32 patients, allowing to identify 157 probe sets differentially expressed in patients with CR versus those failing CR to TD. We then generated an eight-gene GEP signature whose performance was subsequently validated in a training set of 80 patients. A correct prediction of response to TD was found in 71 % of the cases analyzed. The eight genes were downregulated in patients who achieved CR to TD. Comparisons between post-autotransplantation outcomes of the 44 non-CR-predicted patients and of the 36 CR-predicted patients showed that this latter subgroup had a statistically significant benefit in terms of higher rate of CR after autotransplant(s) and longer time to progression, event-free survival, and overall survival. These results can be an important first step to identify at diagnosis those patients who will respond more favourably to a particular treatment strategy.
authors: Istituto di Ematologia Seràgnoli, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale (DIMES), Università degli Studi di Bologna, Via Massarenti, 9-40138, Bologna, Italy. carolina.terragna@unibo.it
authors: Carolina
authors: C
authors: Terragna
authors: Matteo
authors: M
authors: Renzulli
authors: Daniel
authors: D
authors: Remondini
authors: Enrico
authors: E
authors: Tagliafico
authors: Francesco
authors: F
authors: Di Raimondo
authors: Francesca
authors: F
authors: Patriarca
authors: Giovanni
authors: G
authors: Martinelli
authors: Enrica
authors: E
authors: Roncaglia
authors: Luciano
authors: L
authors: Masini
authors: Patrizia
authors: P
authors: Tosi
authors: Elena
authors: E
authors: Zamagni
authors: Paola
authors: P
authors: Tacchetti
authors: Antonio
authors: A
authors: Ledda
authors: Annamaria
authors: A
authors: Brioli
authors: Emanuele
authors: E
authors: Angelucci
authors: Nicoletta
authors: N
authors: Testoni
authors: Giulia
authors: G
authors: Marzocchi
authors: Piero
authors: P
authors: Galieni
authors: Alessandro
authors: A
authors: Gozzetti
authors: Marina
authors: M
authors: Martello
authors: Flores
authors: F
authors: Dico
authors: Katia
authors: K
authors: Mancuso
authors: Michele
authors: M
authors: Cavo
mesh_terms: D000328:Adult; D000368:Aged; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D015996:Survival Rate / Q000639:trends; D013792:Thalidomide / Q000627:therapeutic use*; D014182:Transplantation, Autologous / Q000379:methods; D016896:Treatment Outcome
chemical_list: D013792:Thalidomide; D003907:Dexamethasone