title: Effects of hearing loss on the subcortical representation of speech cues.
abstract: Individuals with sensorineural hearing loss often report frustration with speech being loud but not clear, especially in background noise. Despite advanced digital technology, hearing aid users may resort to removing their hearing aids in noisy environments due to the perception of excessive loudness. In an animal model, sensorineural hearing loss results in greater auditory nerve coding of the stimulus envelope, leading to a relative deficit of stimulus fine structure. Based on the hypothesis that brainstem encoding of the temporal envelope is greater in humans with sensorineural hearing loss, speech-evoked brainstem responses were recorded in normal hearing and hearing impaired age-matched groups of older adults. In the hearing impaired group, there was a disruption in the balance of envelope-to-fine structure representation compared to that of the normal hearing group. This imbalance may underlie the difficulty experienced by individuals with sensorineural hearing loss when trying to understand speech in background noise. This finding advances the understanding of the effects of sensorineural hearing loss on central auditory processing of speech in humans. Moreover, this finding has clinical potential for developing new amplification or implantation technologies, and in developing new training regimens to address this relative deficit of fine structure representation.
authors: Northwestern University, Auditory Neuroscience Laboratory, Communication Sciences, 2240 North Campus Drive, Evanston, Illinois 60208, USA.
authors: Samira
authors: S
authors: Anderson
authors: Alexandra
authors: A
authors: Parbery-Clark
authors: Travis
authors: T
authors: White-Schwoch
authors: Sarah
authors: S
authors: Drehobl
authors: Nina
authors: N
authors: Kraus
mesh_terms: D000161:Acoustic Stimulation; D000368:Aged; D000369:Aged, 80 and over; D001309:Auditory Threshold; D001933:Brain Stem / Q000503:physiopathology*; D016022:Case-Control Studies; D003463:Cues; D004569:Electroencephalography; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009622:Noise / Q000009:adverse effects; D010470:Perceptual Masking; D019986:Persons with Hearing Disabilities / Q000523:psychology*; D013018:Sound Spectrography; D013061:Speech Acoustics; D013065:Speech Intelligibility; D013067:Speech Perception; D013997:Time Factors
references: Neuroimage. 2006 Oct 15;33(1):180-94
references: 16901722
references: Hear Res. 2011 Oct;280(1-2):30-7
references: 21354285
references: PLoS One. 2011 May 11;6(5):e18082
references: 21589653
references: Hear Res. 2003 Apr;178(1-2):35-43
references: 12684175
references: Ann N Y Acad Sci. 2009 Jul;1169:518-33
references: 19673835
references: J Acoust Soc Am. 2009 May;125(5):3328-45
references: 19425674
references: Clin Neurophysiol. 2003 May;114(5):851-9
references: 12738430
references: Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18866-9
references: 17116863
references: Curr Biol. 2012 Aug 7;22(15):1417-22
references: 22727697
references: J Acoust Soc Am. 2009 Jan;125(1):27-30
references: 19173391
references: J Speech Hear Res. 1980 Sep;23(3):646-69
references: 7421164
references: J Assoc Res Otolaryngol. 2010 Dec;11(4):657-73
references: 20556628
references: J Acoust Soc Am. 2011 Jul;130(1):334-49
references: 21786903
references: Ear Hear. 2011 Nov-Dec;32(6):750-7
references: 21730859
references: Brain Res. 2010 Jun 25;1342:24-32
references: 20438718
references: J Acoust Soc Am. 2009 May;125(5):3358-72
references: 19425676
references: Eur J Neurosci. 2002 Dec;16(12):2394-404
references: 12492434
references: J Assoc Res Otolaryngol. 2006 Mar;7(1):71-81
references: 16408166
references: Hear Res. 2011 Oct;280(1-2):177-91
references: 21669269
references: J Acoust Soc Am. 1986 Nov;80(5):1364-74
references: 3782615
references: Cereb Cortex. 2006 Jul;16(7):941-8
references: 16151174
references: Ear Hear. 2012 Jan-Feb;33(1):144-50
references: 21760513
references: Ear Hear. 2010 Dec;31(6):755-60
references: 20592614
references: Hear Res. 2005 Jul;205(1-2):172-83
references: 15953526
references: Front Aging Neurosci. 2012 Nov 23;4:30
references: 23189051
references: J Assoc Res Otolaryngol. 2008 Dec;9(4):399-406
references: 18855069
references: J Acoust Soc Am. 2009 Aug;126(2):568-71
references: 19640020
references: J Neurosci. 2005 Apr 13;25(15):3908-18
references: 15829643
references: J Acoust Soc Am. 2011 Jul;130(1):473-88
references: 21786913
references: J Assoc Res Otolaryngol. 2009 Sep;10(3):407-23
references: 19365691
references: J Acoust Soc Am. 1983 Sep;74(3):739-43
references: 6630729
references: Ear Hear. 1986 Aug;7(4):257-65
references: 3743918
references: Hear Res. 2006 Jan;211(1-2):74-84
references: 16289579
references: J Neurosci. 2012 Oct 10;32(41):14156-64
references: 23055485
references: Hear Res. 2008 Nov;245(1-2):35-47
references: 18765275
references: J Acoust Soc Am. 2011 Nov;130(5):2928-38
references: 22087921
references: J Acoust Soc Am. 2009 Jun;125(6):4023-33
references: 19507983
references: Ear Hear. 1997 Jun;18(3):189-201
references: 9201454
references: Curr Opin Otolaryngol Head Neck Surg. 2004 Oct;12(5):444-8
references: 15377959
references: Acta Otolaryngol. 2009 Sep;129(9):988-91
references: 19052929
references: Acta Otolaryngol. 2007 Dec;127(12):1298-303
references: 17851892
references: Int J Audiol. 2010 Nov;49(11):823-31
references: 20666687
references: Eur Arch Otorhinolaryngol. 2013 Mar;270(4):1223-9
references: 22766835
references: Psychophysiology. 2010 Mar 1;47(2):236-46
references: 19824950
references: J Neurosci. 2012 Feb 1;32(5):1747-56
references: 22302814
references: Otolaryngol Clin North Am. 2012 Feb;45(1):129-40
references: 22115686
references: Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8081-6
references: 10884432
references: J Am Acad Audiol. 2000 Jul-Aug;11(7):390-406
references: 10976500
references: Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4357-62
references: 23401541
references: Nat Neurosci. 2012 Oct;15(10):1362-4
references: 22960931
references: Acta Otolaryngol Suppl. 1990;476:153-5; discussion 156
references: 2087956
references: J Physiol. 2006 Oct 1;576(Pt 1):37-42
references: 16873410