title: Small intestinal bacterial overgrowth and orocecal transit time in patients of inflammatory bowel disease.
abstract: BACKGROUND
  Inflammatory bowel disease (IBD) consists of Ulcerative colitis (UC) and Crohn's disease (CD). These two conditions share many common features-diarrhea, bloody stools, weight loss, abdominal pain, fever and fatigue. Small intestinal bacterial overgrowth (SIBO) is frequent in patients with CD but it has not been studied in UC Indian patients.
  
  
  OBJECTIVE
  The study was planned to measure orocecal transit time (OCTT) and SIBO in UC and CD patients.
  
  
  METHODS
  One hundred thirty-seven patients of IBD (95 UC and 42 CD) and 115 healthy controls were enrolled. OCTT and SIBO were measured by lactulose and glucose hydrogen breath test respectively. Concentration of hydrogen and methane were measured by SC microlyser from Quintron, USA.
  
  
  RESULTS
  Mean±standard deviation (SD) of OCTT in patients of IBD was significantly higher as compared to controls. Furthermore, OCTT was significantly higher in CD patients as compared to UC patients. It was also observed that occurrence of SIBO was significantly higher in IBD patients as compared to controls. The occurrence of SIBO in CD (45.2%) was significantly higher as compared to patients in UC (17.8%) group. Percentage of methane positive IBD patients (2.9%) was significantly lower as compared to methane positive controls (24.4%).
  
  
  CONCLUSIONS
  OCTT was significantly delayed in IBD patients as compared to controls and in CD patients as compared to UC patients. OCTT was significantly higher in SIBO positive IBD patients as compared to SIBO negative patients. Thus, we can suggest that delayed OCTT would have been the cause of increased SIBO in these patients.
authors: Department of Super Specialty Gastroenterology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India. svrana25@hotmail.com
authors: S V
authors: SV
authors: Rana
authors: S
authors: S
authors: Sharma
authors: A
authors: A
authors: Malik
authors: J
authors: J
authors: Kaur
authors: K K
authors: KK
authors: Prasad
authors: S K
authors: SK
authors: Sinha
authors: K
authors: K
authors: Singh
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000382:microbiology / Q000503:physiopathology*; D003424:Crohn Disease / Q000382:microbiology / Q000503:physiopathology*; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D007421:Intestine, Small / Q000382:microbiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
references: J Neurogastroenterol Motil. 2011 Jul;17(3):312-7
references: 21860825
references: Trop Gastroenterol. 2007 Oct-Dec;28(4):159-61
references: 18416345
references: Gastroenterol Clin North Am. 1995 Sep;24(3):475-507
references: 8809232
references: Am J Gastroenterol. 1997 Jul;92(7):1148-53
references: 9219788
references: Dig Dis Sci. 2008 Jul;53(7):1797-800
references: 18095159
references: Arch Immunol Ther Exp (Warsz). 1998;46(3):143-55
references: 9704146
references: Eur J Gastroenterol Hepatol. 1999 Jan;11(1):27-32
references: 10495168
references: Curr Opin Gastroenterol. 1999 Jul;15(4):308-14
references: 17023963
references: J Clin Invest. 1972 May;51(5):1219-25
references: 5020434
references: Am J Gastroenterol. 1992 May;87(5):584-9
references: 1595644
references: Eur J Surg. 1994 Aug;160(8):409-16
references: 7811826
references: Am J Gastroenterol. 2000 Dec;95(12):3503-6
references: 11151884
references: Drugs. 2005;65(16):2253-86
references: 16266194
references: Indian J Gastroenterol. 2006 Jan-Feb;25(1):6-10
references: 16567886
references: J Clin Gastroenterol. 2000 Jul;31(1):63-6
references: 10914780
references: Dig Dis Sci. 2003 Jan;48(1):86-92
references: 12645795
references: Ann Rheum Dis. 2004 Apr;63(4):450-2
references: 15020342
references: J Gastroenterol Hepatol. 2003 May;18(5):540-7
references: 12702046
references: Trop Gastroenterol. 2008 Jan-Mar;29(1):23-5
references: 18564663
references: Digestion. 2012;85(3):243-7
references: 22472730
references: Gastroenterology. 1998 Jul;115(1):182-205
references: 9649475
references: Altern Med Rev. 2003 Aug;8(3):247-83
references: 12946238