title: Inhaled hypertonic saline+hyaluronic acid in cystic fibrosis with asthma-like symptoms: a new therapeutic chance.
abstract: The aim of the paper is to report the case of a boy affected by cystic fibrosis, with non-ABPA-related recurrent wheezing and frequent pulmonary exacerbation during childhood, who had been  inhaling 7% NaCl+0.1% hyaluronic acid (HA) as a maintenance therapy. We reviewed patient database and, analysing a 7-year follow-up, considered pulmonary exacerbation, antibiotic and steroid courses, pulmonary function (forced expiratory volume in one second; FEV1) and microbiological data. After starting 7% NaCl+0.1% HA treatment, we observed a dramatic decrease of oral antibiotic need (0.55 courses/month during the pretreatment period against 0.10 courses/month in the treatment period), associated with a good initial recovery and a stability of FEV1. In our opinion this case could suggest an extended indication for inhaled 7% NaCl+0.1% HA use in CF, not only in patients who did not tolerate hypertonic saline, but also in patients with coexistent asthma-like symptoms.
authors: Cystic Fibrosis Centre, Pediatric Department, IRCCS G. Gaslini, Genova, Italy.
authors: Federico
authors: F
authors: Cresta
authors: Aldo
authors: A
authors: Naselli
authors: Federica
authors: F
authors: Favilli
authors: Rosaria
authors: R
authors: Casciaro
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D008297:Male; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*; D055675:Viscosupplements / Q000008:administration & dosage*
chemical_list: D012462:Saline Solution, Hypertonic; D055675:Viscosupplements; D006820:Hyaluronic Acid
references: Am J Respir Crit Care Med. 2010 Sep 1;182(5):627-32
references: 20463179
references: Curr Opin Pulm Med. 2006 Nov;12(6):445-52
references: 17053496
references: Adv Ther. 2010 Nov;27(11):870-8
references: 20953746
references: J R Soc Med. 1996 Mar;89(3):172P-3P
references: 8683527
references: J Pediatr. 2006 Jul;149(1):142
references: 17243308
references: Pediatr Pulmonol. 1988;5(3):139-44
references: 2973571
references: Cell. 1993 Jul 2;73(7):1251-4
references: 7686820
references: Pulm Pharmacol Ther. 2003;16(6):335-40
references: 14580924
references: Am J Respir Crit Care Med. 2003 May 1;167(9):1169-75
references: 12714341
references: Pulm Pharmacol Ther. 2006;19(4):286-91
references: 16140028