title: Hyperuricemia is an independent risk factor for new onset micro-albuminuria in a middle-aged and elderly population: a prospective cohort study in taiwan.
abstract: BACKGROUND
  Hyperuricemia is now regarded as a risk factor for cardiovascular disease. Micro-albuminuria is associated with increased risk for cardiovascular disease and chronic kidney disease. We hypothesized that elevated serum uric acid (UA) is associated with development of micro-albuminuria in the general population.
  
  
  RESULTS
  We conducted a community-based prospective cohort study. A total of 1862 subjects from southern Taiwan, all older than 40 years, were screened and 993 of these participants without micro-albuminuria were followed for 4 years. Urinary albumin-to-creatinine ratio was measured two times per year. A multiple linear regression model indicated that serum UA was independently associated with ln(ACR) after adjustment for 8 factors (age, sex, and 6 metabolic metrics) (β = 0.194, p<0.01). Logistic regression analysis indicated that each 1 mg/dL increase of UA was associated with a 1.42-fold increased risk of micro-albuminuria after adjustment for the same 8 factors (OR = 1.42, 95% CI: 1.27-1.59, p<0.01). A Cox regression model using subjects with serum UA less than 5 mg/dL as reference group indicated higher hazard ratios (HRs) only found in subjects with serum UA more than 7 mg/dL (HR = 3.54, 95% CI: 2.11-5.93, p<0.01) and not in subjects with serum UA of 5 to 7 mg/dL (HR = 1.30, 95% CI: 0.82-2.07, p = 0.15).
  
  
  CONCLUSIONS
  Hyperuricemia is significantly associated with micro-albuminuria in middle-aged and elderly males and females from a general population in Taiwan. Elevated serum UA is an independent predictor for development of micro-albuminuria in this population.
authors: Department of Nephrology, Chang Gung Memorial Hospital, Chiayi, Taiwan.
authors: Hung-Yu
authors: HY
authors: Chang
authors: Pei-Hsien
authors: PH
authors: Lee
authors: Chen-Chou
authors: CC
authors: Lei
authors: Chun-Wu
authors: CW
authors: Tung
authors: Yung-Chien
authors: YC
authors: Hsu
authors: Tung-Jung
authors: TJ
authors: Huang
authors: Long-Chuan
authors: LC
authors: Lu
authors: Chun-Liang
authors: CL
authors: Lin
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000150:complications*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D016019:Survival Analysis; D013624:Taiwan / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid
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