title: Apheresis-inducible cytokine pattern change in children with homozygous familial hypercholesterolemia.
abstract: Familial hypercholesterolemia is a genetic disorder that leads to severe atherosclerosis related cardiovascular complications in young adults. Extracorporeal elimination is a method of LDL-lowering procedures effective in patients with homozygous or severe heterozygous FH utilized in cases. The recruitment of leucocytes into the arterial intima is dependent on a cascade of events mediated through a diverse family of adhesion molecules. Several pro-inflammatory adhesion molecules are cleared by various lipid apheresis methods. This study showed that, LDL-apheresis led to several changes in circulating inflammatory factors which induced antiinflammatory and antiatherogenic changes in the plasma profile in homozygous familial hypercholesterolemic patients.
authors: Department of Pediatric Metabolism, Gazi University, Turkey. aynurcon@yahoo.com
authors: Aynur
authors: A
authors: Küçükçongar
authors: Idil
authors: I
authors: Yenicesu
authors: Leyla
authors: L
authors: Tümer
authors: Ciğdem Seher
authors: CS
authors: Kasapkara
authors: Fatih Süheyl
authors: FS
authors: Ezgü
authors: Ozge
authors: O
authors: Paşaoğlu
authors: Canan
authors: C
authors: Demirtaş
authors: Bülent
authors: B
authors: Celik
authors: Günter
authors: G
authors: Dilsiz
authors: Alev
authors: A
authors: Hasanoğlu
mesh_terms: D000293:Adolescent; D050197:Atherosclerosis; D001781:Blood Component Removal / Q000379:methods*; D002648:Child; D008078:Cholesterol, LDL / Q000097:blood*; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics* / Q000628:therapy*; D007249:Inflammation; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male
chemical_list: D008078:Cholesterol, LDL; D016207:Cytokines; D008077:Lipoproteins, LDL