title: Acidity constant determination of novel drug precursor benzothiazolon derivatives including acyl and piperazine moieties.
abstract: In this study, protonation and deprotonation behaviors of eight new drug precursor benzothiazolon derivatives in all of acidic and basic scale (super acidic, pH, super basic regions) are analyzed by using UV-visible spectrophotometric technique. Acidity constants (pKa), elucidation of the structure and protonation mechanisms of the studied molecules are obtained. Substituent effect on acidity constant values is discussed. These molecules are protonated from oxygen atom of acetamide group in the keto form. The protonation is found to be considerably contributed by the keto form.
authors: Bitlis Eren University, Faculty of Arts & Science, Department of Physics, 13000 Bitlis, Turkey. isidir@bitliseren.edu.tr
authors: İsa
authors: İ
authors: Sıdır
authors: Yadigar
authors: Y
authors: Gülseven Sıdır
authors: Halil
authors: H
authors: Berber
mesh_terms: D000143:Acids / Q000737:chemistry*; D000215:Acylation; D052160:Benzothiazoles / Q000737:chemistry*; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry*; D011522:Protons; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D000143:Acids; D052160:Benzothiazoles; D010879:Piperazines; D011355:Prodrugs; D011522:Protons; D012996:Solutions; D000077489:Piperazine