title: Comparison of outcomes using AlloDerm versus FlexHD for implant-based breast reconstruction.
abstract: BACKGROUND
  Prosthetic reconstruction using human acellular dermis (ADM) is a common practice in breast reconstruction. AlloDerm and FlexHD are two different forms of ADM, each with unique characteristics. No studies have directly compared the postoperative complications of these 2 products.
  
  
  METHODS
  The outcomes of 547 consecutive implant-based breast reconstructions were reviewed.
  
  
  RESULTS
  Reconstruction was performed in 382 consecutive women (547 total breasts), employing mostly immediate reconstruction (81%). Mean follow-up was 6.4 months. Among immediate reconstructions, 165 used AlloDerm and 97 used FlexHD. Complications were similar by univariate analysis. In multivariate analysis, smoking and higher initial implant fill were risk factors for delayed healing. The use of FlexHD, single-stage reconstruction, and smoking were independent risk factors for implant loss.
  
  
  CONCLUSIONS
  There is no significant difference in the complication rates between AlloDerm and FlexHD in immediate breast reconstruction. Multivariate analysis suggests that FlexHD may be a risk factor for implant loss.
authors: From the Department of Surgery, Division of Plastic Surgery, University of Washington School of Medicine, Seattle, Washington.
authors: Daniel Z
authors: DZ
authors: Liu
authors: David W
authors: DW
authors: Mathes
authors: Peter C
authors: PC
authors: Neligan
authors: Hakim K
authors: HK
authors: Said
authors: Otway
authors: O
authors: Louie
mesh_terms: D062088:Acellular Dermis; D019928:Breast Implantation / Q000379:methods*; D018427:Breast Implants; D002481:Cellulitis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D003094:Collagen / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D019544:Equipment Failure Analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D016462:Mammaplasty / Q000379:methods*; D008408:Mastectomy / Q000379:methods / Q000706:statistics & numerical data; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology; D011475:Prosthesis Failure / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D016038:Skin Transplantation / Q000009:adverse effects* / Q000379:methods; D012907:Smoking / Q000453:epidemiology; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000209:etiology; D015626:Tissue Expansion / Q000295:instrumentation / Q000379:methods; D015625:Tissue Expansion Devices; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: C440568:Alloderm; C582618:FlexHD; D003094:Collagen