title: Uric acid lowering to prevent kidney function loss in diabetes: the preventing early renal function loss (PERL) allopurinol study.
abstract: Diabetic kidney disease causes significant morbidity and mortality among people with type 1 diabetes (T1D). Intensive glucose and blood pressure control have thus far failed to adequately curb this problem and therefore a major need for novel treatment approaches exists. Multiple observations link serum uric acid levels to kidney disease development and progression in diabetes and strongly argue that uric acid lowering should be tested as one such novel intervention. A pilot of such a trial, using allopurinol, is currently being conducted by the Preventing Early Renal Function Loss (PERL) Consortium. Although the PERL trial targets T1D individuals at highest risk of kidney function decline, the use of allopurinol as a renoprotective agent may also be relevant to a larger segment of the population with diabetes. As allopurinol is inexpensive and safe, it could be cost-effective even for relatively low-risk patients, pending the completion of appropriate trials at earlier stages.
authors: Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA.
authors: David M
authors: DM
authors: Maahs
authors: Luiza
authors: L
authors: Caramori
authors: David Z I
authors: DZ
authors: Cherney
authors: Andrzej T
authors: AT
authors: Galecki
authors: Chuanyun
authors: C
authors: Gao
authors: Diana
authors: D
authors: Jalal
authors: Bruce A
authors: BA
authors: Perkins
authors: Rodica
authors: R
authors: Pop-Busui
authors: Peter
authors: P
authors: Rossing
authors: Michael
authors: M
authors: Mauer
authors: Alessandro
authors: A
authors: Doria
mesh_terms: D000493:Allopurinol / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D000493:Allopurinol
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