title: Clinical and imaging parameters to predict cardiovascular outcome in asymptomatic subjects.
abstract: We aimed to compare the prognostic power of clinical parameters, biomarkers and imaging parameters in predicting cardiovascular outcome in asymptomatic healthy population. A total of 5,182 asymptomatic patients who visited Health Promotion Center at Seoul National University Bundang Hospital between January 2006 and September 2008 and had coronary computed tomography angiography were evaluated. All cardiovascular events including cardiac death, acute coronary syndrome and stroke were evaluated as outcome. In asymptomatic general Korean population, cardiovascular event was found in 1.3 % during median follow up period of 48 months. Various multivariate analyses including C-reactive protein, Framingham risk score (FRS), coronary artery calcium score and degree of coronary artery stenosis showed that FRS and degree of coronary artery stenosis were independent parameters for future adverse cardiovascular events in asymptomatic population (OR 1.068, 95 % CI 1.023-1.114, p = 0.003 for FRS, OR 1.041, 95 % CI 1.031-1.051, p < 0.001 for stenosis). The C-statistics of FRS, degree of stenosis and FRS with degree of stenosis were 0.72 (95 % CI 0.64-0.80), 0.80 (95 % CI 0.72-0.88) and 0.83 (95 % CI 0.75-0.91), respectively. Among the clinical parameters, biomarkers and imaging parameters of cardiovascular disease, both FRS and degree of coronary artery stenosis are independent parameters to predict adverse outcome in asymptomatic population.
authors: Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea.
authors: Hyo Eun
authors: HE
authors: Park
authors: Eun-Ju
authors: EJ
authors: Chun
authors: Sang-Il
authors: SI
authors: Choi
authors: Seung-Pyo
authors: SP
authors: Lee
authors: Chang-Hwan
authors: CH
authors: Yoon
authors: Hyung-Kwan
authors: HK
authors: Kim
authors: Tae-Jin
authors: TJ
authors: Youn
authors: Yong-Jin
authors: YJ
authors: Kim
authors: Dong-Ju
authors: DJ
authors: Choi
authors: Dae-Won
authors: DW
authors: Sohn
authors: Goo-Yeong
authors: GY
authors: Cho
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D017023:Coronary Angiography / Q000379:methods*; D023921:Coronary Stenosis / Q000097:blood* / Q000000981:diagnostic imaging* / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
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