title: Statin use and peripheral blood progenitor cells mobilization in patients with multiple myeloma.
abstract: OBJECTIVE
  Statins have beneficial effects in patients after myocardial infarction and at least part of the benefit results from mobilization of marrow endothelial progenitors to repopulate damaged myocardial tissues. This study examines if statins may have the same effect in mobilizing marrow progenitors to be harvested and subsequently used in high-dose chemotherapy with progenitor cell rescue in multiple myeloma.
  
  
  METHODS
  From 2006 to 2012, 86 patients with multiple myeloma were mobilized with the use of G-CSF and were retrospectively analyzed. Patients with other malignancies or mobilized with the use of chemotherapy or with plerixafor were excluded.
  
  
  RESULTS
  The median age of the patients was 60 years. 72 patients had received one line of chemotherapy and 14 patients two or more lines of chemotherapy. Twenty patients were taking statins at the time of the harvest while 66 patients were not. In the group of patients taking statins the success rate of first leukapheresis (obtaining the target number of 4 × 10(6) CD34+ cells/kg) was 85 % while in the group not taking statins this rate was 63.6 %. Despite the comparatively small number of patients this difference approached statistical significance (χ (2) = 0.07).
  
  
  CONCLUSIONS
  This retrospective analysis of 86 patients shows for the first time a possible benefit of statins for peripheral blood progenitor cells mobilization in patients with multiple myeloma. Larger studies would be required to clarify the issue. If their effectiveness is confirmed, statins could be a safe and cheaper addition to chemotherapy and plerixafor for peripheral hematopoietic stem cell mobilization.
authors: Department of Medical Oncology, University Hospital of Lausanne, Lausanne, Switzerland.
authors: A
authors: A
authors: Stravodimou
authors: I A
authors: IA
authors: Voutsadakis
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
references: Ann Hematol. 2011 Oct;90(10):1161-6
references: 21698395
references: Circ Res. 2001 Jul 6;89(1):E1-7
references: 11440984
references: Leukemia. 2012 Jan;26(1):23-33
references: 21788948
references: Blood. 2005 Jan 1;105(1):199-206
references: 15345590
references: Atherosclerosis. 2012 Apr;221(2):303-10
references: 22071358
references: PLoS One. 2011 Jan 25;6(1):e16413
references: 21283543
references: Biol Blood Marrow Transplant. 2009 Jun;15(6):718-23
references: 19450756
references: J Clin Oncol. 2006 Jan 20;24(3):431-6
references: 16365178
references: Bone Marrow Transplant. 2011 Nov;46(11):1426-9
references: 21217788
references: J Exp Med. 2011 Mar 14;208(3):421-8
references: 21402747
references: Clin Cancer Res. 2012 Jul 1;18(13):3524-31
references: 22529099
references: Nat Med. 2003 Nov;9(11):1370-6
references: 14556003
references: Kidney Int. 2005 May;67(5):1672-6
references: 15840010
references: Am J Med. 2012 May;125(5):440-6
references: 22387091
references: Am J Physiol Cell Physiol. 2006 Dec;291(6):C1208-12
references: 16885396
references: Biol Blood Marrow Transplant. 2008 Mar;14(3):351-2
references: 18275902
references: Atherosclerosis. 2007 Jun;192(2):413-20
references: 16837000
references: Circ Res. 2009 Jan 30;104(2):255-64, 10p following 264
references: 19096024
references: Blood. 2005 May 15;105(10):3833-40
references: 15292067
references: J Exp Med. 2011 Feb 14;208(2):251-60
references: 21282380
references: Blood. 2009 Aug 27;114(9):1729-35
references: 19561323
references: J Clin Invest. 2001 Aug;108(3):391-7
references: 11489932
references: Cell Stem Cell. 2012 Aug 3;11(2):143-4
references: 22862939
references: Circulation. 2004 Jun 1;109(21 Suppl 1):II34-41
references: 15173061
references: Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):257-66
references: 16322535
references: Nat Rev Immunol. 2010 Mar;10(3):201-9
references: 20182459
references: J Immunol. 2012 Jan 1;188(1):85-102
references: 22140257