title: Differences in the behavior of advanced glycation end products and advanced oxidation protein products in patients with allergic rhinitis.
abstract: BACKGROUND
  The presence of oxidative stress in patients with asthma is well documented; however, the role of oxidative stress in allergic rhinitis has received less attention, although it is likely to be similar to that observed in patients with asthma. Advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) are compounds formed by the transformation of macromolecules, including proteins, which can serve as densitometric markers of oxidative stress and inflammation in several diseases.
  
  
  OBJECTIVE
  The aim of this study was to investigate the role of AGEs and AOPPs as new markers of oxidative stress and inflammation in patients affected by allergic rhinitis.
  
  
  METHODS
  AGE and AOPP levels were determined in the sera of 25 patients with allergic rhinitis and 64 healthy controls. AGEs and AOPPs were detected using spectrofluorimetry and spectrophotometry, respectively.
  
  
  RESULTS
  AGE levels in patients were significantly higher than those in controls (P < .0001). These levels were not affected by the presence of asthma. No statistically significant differences were found between AOPP levels in patients or controls (P = .38).
  
  
  CONCLUSIONS
  Formation of AGEs and AOPPs may be accelerated in immunological and respiratory disorders such as asthma. Depending on the marker evaluated, the presence or absence of oxidative stress in allergic rhinitis is controversial. To our knowledge, this is the first study showing the possible involvement of AGEs in allergic rhinitis. The different behavior observed for these 2 biomarkers is very likely due to the activation of specific related biochemical pathways (eg, the myeloperoxidase pathway) associated with the condition under study.
authors: Dipartimento BioMedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy.
authors: G
authors: G
authors: Di Lorenzo
authors: P L
authors: PL
authors: Minciullo
authors: M S
authors: MS
authors: Leto-Barone
authors: S
authors: S
authors: La Piana
authors: G
authors: G
authors: La Porta
authors: A
authors: A
authors: Saija
authors: S
authors: S
authors: Gangemi
mesh_terms: D000328:Adult; D062107:Advanced Oxidation Protein Products / Q000097:blood* / Q000276:immunology; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000276:immunology; D009195:Peroxidase / Q000097:blood / Q000276:immunology; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D013050:Spectrometry, Fluorescence; D013053:Spectrophotometry
chemical_list: D062107:Advanced Oxidation Protein Products; D015415:Biomarkers; D017127:Glycation End Products, Advanced; D007073:Immunoglobulin E; D009195:Peroxidase