title: Atlas-based neuroinformatics via MRI: harnessing information from past clinical cases and quantitative image analysis for patient care.
abstract: With the ever-increasing amount of anatomical information radiologists have to evaluate for routine diagnoses, computational support that facilitates more efficient education and clinical decision making is highly desired. Despite the rapid progress of image analysis technologies for magnetic resonance imaging of the human brain, these methods have not been widely adopted for clinical diagnoses. To bring computational support into the clinical arena, we need to understand the decision-making process employed by well-trained clinicians and develop tools to simulate that process. In this review, we discuss the potential of atlas-based clinical neuroinformatics, which consists of annotated databases of anatomical measurements grouped according to their morphometric phenotypes and coupled with the clinical informatics upon which their diagnostic groupings are based. As these are indexed via parametric representations, we can use image retrieval tools to search for phenotypes along with their clinical metadata. The review covers the current technology, preliminary data, and future directions of this field.
authors: The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. susumu@mri.jhu.edu
authors: Susumu
authors: S
authors: Mori
authors: Kenichi
authors: K
authors: Oishi
authors: Andreia V
authors: AV
authors: Faria
authors: Michael I
authors: MI
authors: Miller
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001921:Brain / Q000473:pathology; D002986:Clinical Trials as Topic; D019295:Computational Biology / Q000379:methods; D016208:Databases, Factual; D003657:Decision Making; D020000:Decision Support Systems, Clinical; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008490:Medical Informatics / Q000379:methods; D009462:Neurology / Q000379:methods*; D010641:Phenotype
references: Med Image Comput Comput Assist Interv. 2007;10(Pt 1):294-301
references: 18051071
references: J Comput Assist Tomogr. 1994 Mar-Apr;18(2):192-205
references: 8126267
references: Neuroimage. 2008 Jun;41(2):448-61
references: 18407524
references: IEEE Trans Inf Technol Biomed. 2010 Jul;14(4):897-903
references: 20064763
references: Comput Med Imaging Graph. 1996 Jul-Aug;20(4):209-17
references: 8954229
references: IEEE Trans Med Imaging. 2010 Dec;29(12):2000-8
references: 20667809
references: Neuroimage. 2010 Feb 1;49(3):2352-65
references: 19857578
references: Neuroimage. 2011 Jan 1;54(1):313-27
references: 20656036
references: Open Med Inform J. 2011;5(Suppl 1):58-72
references: 21892374
references: IEEE Trans Med Imaging. 2004 Jul;23(7):903-21
references: 15250643
references: Med Image Comput Comput Assist Interv. 2006;9(Pt 2):389-96
references: 17354796
references: IEEE Trans Med Imaging. 2002 Aug;21(8):924-33
references: 12472265
references: Brain. 2012 May;135(Pt 5):1508-21
references: 22544901
references: Neuroimage. 2000 Jun;11(6 Pt 1):805-21
references: 10860804
references: J Am Coll Radiol. 2010 Jul;7(7):501-6
references: 20630384
references: Neuroimage. 2009 Jun;46(2):486-99
references: 19385016
references: Neuroimage. 2012 Aug 15;62(2):911-22
references: 22248580
references: Med Image Anal. 2001 Sep;5(3):185-94
references: 11524225
references: Med Inform (Lond). 1994 Jan-Mar;19(1):47-59
references: 7934304
references: Comput Stat Data Anal. 2006 Jan;50(2):551-567
references: 20467574
references: IEEE Trans Med Imaging. 2008 Apr;27(4):442-56
references: 18390342
references: Med Image Anal. 2006 Oct;10(5):764-85
references: 16899392
references: IEEE Trans Med Imaging. 2008 Apr;27(4):495-508
references: 18390346
references: IEEE Trans Med Imaging. 1998 Dec;17(6):1049-62
references: 10048862
references: IEEE Trans Med Imaging. 2001 Jan;20(1):45-57
references: 11293691
references: Radiology. 2004 Jan;230(1):77-87
references: 14645885
references: Stat Methods Med Res. 1997 Sep;6(3):267-99
references: 9339500
references: Neuroimage. 2009 Jul 1;46(3):726-38
references: 19245840
references: IEEE Trans Med Imaging. 2001 Apr;20(4):257-70
references: 11370893
references: Neuroimage. 2006 May 15;31(1):228-39
references: 16466677
references: IEEE Trans Med Imaging. 1997 Dec;16(6):864-77
references: 9533586
references: Trends Neurosci. 1998 Nov;21(11):460-8
references: 9829685
references: Med Image Anal. 2004 Sep;8(3):285-94
references: 15450223
references: IEEE Trans Med Imaging. 2012 Jun;31(6):1181-94
references: 22318484
references: Radiology. 2009 Sep;252(3):852-6
references: 19717755
references: Med Image Comput Comput Assist Interv. 2010;13(Pt 2):290-7
references: 20879327
references: Proc AMIA Annu Fall Symp. 1996;:299-303
references: 8947676
references: Nat Rev Neurosci. 2006 Dec;7(12):952-66
references: 17115077
references: Hum Brain Mapp. 2000 Feb;9(2):81-92
references: 10680765
references: Radiology. 2000 Jul;216(1):291-7
references: 10887264
references: Med Image Anal. 1997 Apr;1(3):225-43
references: 9873908
references: AJNR Am J Neuroradiol. 1997 Apr;18(4):705-10
references: 9127034
references: Radiology. 2009 Oct;253(1):23-5
references: 19789252
references: Neuroimage. 2001 May;13(5):847-55
references: 11304081
references: Neuroimage. 1999 Feb;9(2):179-94
references: 9931268
references: Neuroimage. 2010 Aug 15;52(2):415-28
references: 20420929
references: Neuroimage. 2001 Jul;14(1 Pt 1):21-36
references: 11525331
references: Neuroimage. 1995 Jun;2(2):89-101
references: 9343592
references: Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11944-8
references: 8265653
references: Neuroimage. 2006 Jul 15;31(4):1487-505
references: 16624579
references: Med Image Anal. 2012 Jul;16(5):933-51
references: 22465077
references: IEEE Trans Inf Technol Biomed. 2007 Jan;11(1):58-69
references: 17249404
references: IEEE Trans Med Imaging. 2003 Jan;22(1):105-19
references: 12703764
references: J Comput Assist Tomogr. 1998 Mar-Apr;22(2):324-33
references: 9530404
references: Neuroimage. 2005 Oct 1;27(4):979-90
references: 15990339
references: IEEE Trans Inf Technol Biomed. 2007 Mar;11(2):190-202
references: 17390989
references: IEEE Trans Med Imaging. 1997 Dec;16(6):878-86
references: 9533587
references: Magn Reson Med. 1998 Jun;39(6):935-40
references: 9621917
references: Neuroimage. 2004;23 Suppl 1:S208-19
references: 15501092
references: Proc Natl Acad Sci U S A. 2005 May 10;102(19):6978-83
references: 15860588
references: Hum Brain Mapp. 1999;7(4):254-66
references: 10408769
references: IEEE Trans Med Imaging. 2009 Aug;28(8):1266-77
references: 19228554
references: Philos Trans R Soc Lond B Biol Sci. 2001 Aug 29;356(1412):1293-322
references: 11545704
references: J Comput Assist Tomogr. 1983 Aug;7(4):618-25
references: 6602820
references: Radiographics. 2005 May-Jun;25(3):849-58
references: 15888631
references: Neuroimage. 2006 Oct 15;33(1):115-26
references: 16860573
references: Radiology. 1997 Feb;202(2):504-10
references: 9015081
references: Neuroimage. 2003 Jul;19(3):1033-48
references: 12880830
references: Neuroimage. 2009 Mar;45(1 Suppl):S61-72
references: 19041946
references: J Comput Assist Tomogr. 1997 Jul-Aug;21(4):567-81
references: 9216760
references: Neuroimage. 2007 Oct 15;38(1):95-113
references: 17761438
references: Cortex. 2008 Sep;44(8):1105-32
references: 18619589
references: J Comput Assist Tomogr. 1993 Mar-Apr;17(2):225-36
references: 8454749
references: J Magn Reson Imaging. 2000 Dec;12(6):799-807
references: 11105017
references: Acad Radiol. 2004 Mar;11(3):345-58
references: 15035525
references: Int J Med Inform. 2004 Feb;73(1):1-23
references: 15036075
references: Neuroimage. 2011 Jun 1;56(3):907-22
references: 21352927
references: Magn Reson Imaging. 2009 Oct;27(8):1163-74
references: 19249168
references: J Cogn Neurosci. 1996;8(1):1-28
references: 11539144
references: Comput Med Imaging Graph. 1996 Jul-Aug;20(4):193-207
references: 8954228
references: IEEE Trans Med Imaging. 1999 Sep;18(9):737-52
references: 10571379
references: Med Image Anal. 2010 Feb;14(1):39-49
references: 19897403
references: Neuroimage. 2009 Jan 15;44(2):385-98
references: 18840532
references: Neuroimage. 2005 Jan 15;24(2):261-80
references: 15627570
references: Neuroimage. 2007 Feb 15;34(4):1612-8
references: 17188896
references: Neuron. 2002 Jan 31;33(3):341-55
references: 11832223
references: Neuroimage. 2004 Apr;21(4):1428-42
references: 15050568
references: J Clin Epidemiol. 1996 Jul;49(7):749-54
references: 8691224
references: IEEE Trans Med Imaging. 2003 Jun;22(6):773-6
references: 12872953
references: J Digit Imaging. 2000 May;13(2):70-81
references: 10843252
references: Radiographics. 2001 Mar-Apr;21(2):535-47
references: 11259717
references: Neuroimage. 1999 Feb;9(2):195-207
references: 9931269
references: Neuroinformatics. 2003;1(1):1-2
references: 15055390
references: Neuroimage. 2009 Aug 15;47(2):618-27
references: 19398016
references: Neuroimage. 1995 Dec;2(4):244-52
references: 9343609