title: Autophagy in kidney health and disease.
abstract: CONCLUSIONS
  Autophagy is emerging as an important pathway in many biological processes and diseases. This review summarizes the current progress on the role of autophagy in renal physiology and pathology.
  
  
  BACKGROUND
  Studies from renal cells in culture, human kidney tissues, and experimental animal models implicate that autophagy regulates many critical aspects of normal and disease conditions in the kidney, such as diabetic nephropathy and other glomerular diseases, tubular injuries, kidney development and aging, cancer, and genetic diseases associated with the kidney.
  
  
  RESULTS
  The importance of autophagy in the kidney has just started to be elucidated. How the process of autophagy is altered in the pathogenesis of kidney diseases and how this alteration is beneficial or detrimental to kidney functions still need to be fully understood.
  
  
  CONCLUSIONS
  Investigations that uncover the precise mechanism and regulation of autophagy in various kidney diseases may lead to new strategies for therapeutic modulation.
authors: Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts.
authors: Zhibo
authors: Z
authors: Wang
authors: Mary E
authors: ME
authors: Choi
mesh_terms: D000375:Aging / Q000473:pathology; D000818:Animals; D001343:Autophagy / Q000235:genetics*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007674:Kidney Diseases / Q000145:classification / Q000235:genetics* / Q000503:physiopathology
references: J Am Soc Nephrol. 2011 May;22(5):902-13
references: 21493778
references: Clin Exp Nephrol. 2010 Apr;14(2):112-22
references: 20013139
references: Age (Dordr). 2012 Apr;34(2):329-39
references: 21455601
references: PLoS One. 2011;6(8):e23566
references: 21858169
references: Am J Physiol Renal Physiol. 2008 Apr;294(4):F777-87
references: 18256309
references: Trends Cell Biol. 2012 Aug;22(8):407-17
references: 22748206
references: Biochem Biophys Res Commun. 2006 Feb 3;340(1):296-301
references: 16364254
references: Autophagy. 2012 May 1;8(5):826-37
references: 22617445
references: Mol Biol Rep. 2012 Sep;39(9):9085-93
references: 22733486
references: Virchows Arch B Cell Pathol Incl Mol Pathol. 1992;61(6):367-73
references: 1349776
references: J Clin Invest. 2011 Jun;121(6):2197-209
references: 21606591
references: Diabetologia. 2013 Jan;56(1):204-17
references: 23090186
references: J Biomed Sci. 2009 Feb 11;16:19
references: 19272187
references: Am J Nephrol. 2010;31(4):363-74
references: 20332614
references: Nephrology (Carlton). 2012 Feb;17(2):148-59
references: 22085202
references: Am J Physiol Renal Physiol. 2012 Jul 1;303(1):F120-9
references: 22535799
references: Exp Diabetes Res. 2011;2011:908185
references: 21949662
references: Toxicol Sci. 2009 Mar;108(1):124-31
references: 19126599
references: Am J Pathol. 2010 Mar;176(3):1181-92
references: 20075199
references: J Clin Invest. 2011 Jun;121(6):2181-96
references: 21606597
references: Antioxid Redox Signal. 2006 Jan-Feb;8(1-2):152-62
references: 16487049
references: Am J Pathol. 2010 Aug;177(2):632-43
references: 20616344
references: Am J Physiol Renal Physiol. 2012 Apr 1;302(7):F853-64
references: 22160772
references: Am J Physiol Renal Physiol. 2011 Jul;301(1):F110-7
references: 21429968
references: Toxicol Sci. 2011 May;121(1):31-42
references: 21325019
references: Kidney Int. 2005 Aug;68(2):552-61
references: 16014032
references: Cell Biochem Funct. 2013 Jul;31(5):427-33
references: 23086777
references: PLoS One. 2013;8(1):e54918
references: 23349989
references: Virchows Arch B Cell Pathol Incl Mol Pathol. 1992;61(6):359-66
references: 1349775
references: Autophagy. 2012 Apr;8(4):445-544
references: 22966490
references: Transplantation. 2011 Jun 15;91(11):1192-7
references: 21577181
references: J Clin Invest. 2010 Apr;120(4):1043-55
references: 20335657
references: Am J Nephrol. 2007;27(5):495-502
references: 17671379
references: Int J Mol Med. 2013 Mar;31(3):628-36
references: 23314838
references: Antioxid Redox Signal. 2012 Sep 1;17(5):794-802
references: 22077334
references: J Am Soc Nephrol. 2005 Jan;16(1):46-51
references: 15563559
references: J Am Soc Nephrol. 2012 Mar;23(3):412-20
references: 22193387
references: Cancer Cell. 2008 Jul 8;14(1):90-102
references: 18598947
references: J Clin Invest. 2010 Apr;120(4):1084-96
references: 20200449
references: Asian Pac J Cancer Prev. 2012;13(6):2739-44
references: 22938451
references: J Nutr Biochem. 2013 May;24(5):796-802
references: 22898567
references: Science. 2011 May 20;332(6032):966-70
references: 21512002
references: Kidney Blood Press Res. 1997;20(4):258-63
references: 9398032
references: Toxicol Sci. 2008 Nov;106(1):140-52
references: 18632727
references: Life Sci. 2010 Jul 31;87(5-6):147-53
references: 20600147
references: Biochem Biophys Res Commun. 2009 Jul 10;384(4):471-5
references: 19422788
references: J Submicrosc Cytol Pathol. 2006 Jun-Sep;38(2-3):167-74
references: 17784646
references: J Proteomics. 2012 Jul 16;75(13):3866-76
references: 22595305
references: Autophagy. 2008 Aug;4(6):783-91
references: 18628650
references: Transplantation. 2007 Nov 15;84(9):1183-90
references: 17998875
references: Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12455-60
references: 21746920
references: Cancer Cell. 2012 Apr 17;21(4):532-46
references: 22516261
references: Diabetes. 2011 Mar;60(3):981-92
references: 21282369
references: FASEB J. 2003 Jun;17(9):1165-7
references: 12709412
references: J Am Soc Nephrol. 2010 Feb;21(2):272-83
references: 19959713
references: Am J Physiol Renal Physiol. 2008 Mar;294(3):F508-17
references: 18094035
references: Am J Pathol. 2010 Jan;176(1):40-50
references: 20008137
references: Nature. 2010 Jun 17;465(7300):942-6
references: 20526321
references: Pathobiology. 2009;76(5):221-6
references: 19816081
references: Toxicol Appl Pharmacol. 2010 Nov 1;248(3):249-58
references: 20713077
references: J Am Soc Nephrol. 2013 Apr;24(5):727-43
references: 23492732
references: Am J Pathol. 2012 Feb;180(2):517-25
references: 22265049
references: Kidney Int. 2012 Dec;82(12):1271-83
references: 22854643
references: Int J Mol Med. 2012 May;29(5):781-90
references: 22322529
references: Biol Chem. 2012 Jul;393(7):547-64
references: 22944659
references: Mol Biol Cell. 2004 Mar;15(3):1101-11
references: 14699058
references: Toxicol Appl Pharmacol. 2012 Mar 15;259(3):395-401
references: 22015446
references: Diabetes. 2008 Jun;57(6):1446-54
references: 18511445
references: PLoS One. 2012;7(7):e41831
references: 22848625
references: Mech Ageing Dev. 2012 Jun;133(6):387-400
references: 22561310
references: Nat Cell Biol. 2010 Sep;12(9):814-22
references: 20811353
references: N Engl J Med. 2010 Aug 26;363(9):820-9
references: 20581391
references: Kidney Int. 2004 Jun;65(6):2135-44
references: 15149326
references: Am J Physiol Renal Physiol. 2011 May;300(5):F1235-43
references: 21270095
references: Am J Physiol Cell Physiol. 2010 Aug;299(2):C488-96
references: 20484657
references: Cell Mol Life Sci. 2008 Nov;65(22):3640-52
references: 18850067
references: Nature. 2011 Jan 20;469(7330):323-35
references: 21248839
references: Autophagy. 2011 Jul;7(7):673-82
references: 21646866
references: N Engl J Med. 2010 Aug 26;363(9):830-40
references: 20581392
references: J Pharmacol Exp Ther. 2010 May;333(2):454-64
references: 20179157
references: Kidney Int. 2008 Sep;74(5):631-40
references: 18509315
references: Exp Cell Res. 2012 Feb 1;318(3):238-50
references: 22146761
references: Pediatr Nephrol. 2013 Jan;28(1):51-9
references: 22903658
references: J Biomed Sci. 2011 Jun 23;18(1):47
references: 21699681
references: J Biol Chem. 2002 Dec 6;277(49):47257-62
references: 12374793
references: J Am Soc Nephrol. 2006 May;17(5):1395-404
references: 16597691
references: J Biol Chem. 2012 Apr 6;287(15):11677-88
references: 22351764
references: Am J Physiol Renal Physiol. 2012 Feb 1;302(3):F380-9
references: 22049402
references: Eur J Pharmacol. 2010 Dec 15;649(1-3):382-9
references: 20854812
references: J Biol Chem. 2010 Nov 26;285(48):37909-19
references: 20876581
references: Pediatr Nephrol. 2012 Nov;27(11):2137-2144
references: 22714671
references: J Am Soc Nephrol. 2010 Oct;21(10):1702-12
references: 20705711
references: Am J Pathol. 2010 Apr;176(4):1767-78
references: 20150430
references: Am J Physiol Renal Physiol. 2013 Jan 15;304(2):F156-67
references: 23152292
references: Nat Chem Biol. 2011 Jan;7(1):9-17
references: 21164513
references: Am J Physiol Renal Physiol. 2007 May;292(5):F1471-8
references: 17299140
references: J Am Soc Nephrol. 2011 Dec;22(12):2203-12
references: 22052048
references: Diabetes. 2005 Jun;54(6):1615-25
references: 15919781
references: Virchows Arch B Cell Pathol. 1975 Sep 29;19(1):51-67
references: 170735
references: Am J Physiol Renal Physiol. 2007 Feb;292(2):F617-27
references: 17018841
references: Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5466-71
references: 16567633
references: Transplant Proc. 2009 Jan-Feb;41(1):52-4
references: 19249473
references: Life Sci. 2010 Jan 16;86(3-4):115-23
references: 19962996
references: Curr Diab Rep. 2011 Aug;11(4):330-6
references: 21557044
references: Biochem Biophys Res Commun. 2008 Mar 28;368(1):100-6
references: 18222169
references: J Am Soc Nephrol. 2011 Dec;22(12):2193-202
references: 22034640