title: Vitreous fluid and circulating levels of soluble lr11, a novel marker for progression of diabetic retinopathy.
abstract: BACKGROUND
  To evaluate the vitreous fluid levels of soluble LR11 (sLR11), a novel circulating marker for proliferative diabetic retinopathy (PDR), in patients with PDR and non-PDR (NPDR) in comparison to those in patients with non-diabetic ocular diseases.
  
  
  METHODS
  Twenty NPDR and 60 PDR cases were included. Twenty-four subjects with a macular hole were served as a control group. The sLR11 levels of vitreous fluid and serum were determined by sandwich enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The serum sLR11 levels in the PDR and NPDR groups were 12.3 ± 5.0 ng/ml and 10.0 ± 2.7 ng/ml, respectively. The sLR11 levels in the vitreous fluid in the PDR (17.8 ± 6.2 ng/ml) and NPDR (17.4 ± 7.1 ng/ml) groups were significantly higher than those in the control subjects (12.3 ± 4.5 ng /ml) (P = 0.0003 and P = 0.006, respectively). The vitreous fluid levels of sLR11 were not significantly different between the PDR and NPDR groups, and the levels were not significantly correlated with the serum levels of sLR11 in the patients with PDR or NPDR.
  
  
  CONCLUSIONS
  Vitreous fluid sLR11 level may be a novel risk factor for the early development of PDR prior to the increase in circulating levels in diabetic patients.
authors: Department of Ophthalmology, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba, 285-8741, Japan, tomoaki-s@sakura.med.toho-u.ac.jp.
authors: Tomoaki
authors: T
authors: Shiba
authors: Hideaki
authors: H
authors: Bujo
authors: Mao
authors: M
authors: Takahashi
authors: Yukihiro
authors: Y
authors: Sato
authors: Meizi
authors: M
authors: Jiang
authors: Yuichi
authors: Y
authors: Hori
authors: Takatoshi
authors: T
authors: Maeno
authors: Kohji
authors: K
authors: Shirai
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D003930:Diabetic Retinopathy / Q000175:diagnosis* / Q000378:metabolism; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000378:metabolism*; D008297:Male; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008875:Middle Aged; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D026502:LDL-Receptor Related Proteins; D026901:Membrane Transport Proteins; C102582:SORL1 protein, human
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