title: Preparation, in vitro and in vivo evaluation of budesonide loaded core/shell nanofibers as oral colonic drug delivery system.
abstract: Budesonide (BUD) loaded ethylcellulose (EC)-core/Eudragit S100-shell nanofibers (BUD-core/shell-NFs) have been successfully prepared using a coaxial electrospinning technique. The drug encapsulation efficiency was 90.48%. SEM and TEM analysis showed that fine core-shell structured nanofibers with an average diameter 190 nm and uniform core diameters 74 nm were prepared. The BUD-loaded Eudragit S100/EC composite nanofibers (BUD-NFs) were prepared using a blend electrospinning method and used as a control. In vitro release tests in HCl 0.1 N, phosphate buffer solutions pH 6.8 and 7.4 were studied. Moreover, the colon-specific characteristics were directly proven in vivo by the content of BUD in different segments of the gastrointestinal (GI) tract in rats after oral administration. Taken together, the results confirmed that BUD-core/shell-NFs had desired pH-dependent drug release profile, displayed a sustained and complete drug release in the colon, as well as protected BUD from being released completely in the upper portion of the GI tract. Compared with BUD-NFs, the BUD-core/shell-NFs have much better potential to be developed as oral colon-specific drug delivery system (OCDDS) to overcome the disadvantages of current oral formulations of BUD.
authors: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Southeast University, Nanjing, 210009, China.
authors: Qian
authors: Q
authors: Xu
authors: Niping
authors: N
authors: Zhang
authors: Wei
authors: W
authors: Qin
authors: Jingjing
authors: J
authors: Liu
authors: Zhangjun
authors: Z
authors: Jia
authors: Hongxiang
authors: H
authors: Liu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019819:Budesonide / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D005260:Female; D041981:Gastrointestinal Tract / Q000378:metabolism*; D008297:Male; D008422:Materials Testing; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry*; D016062:Porosity; D051381:Rats
chemical_list: D003692:Delayed-Action Preparations; D053769:Nanocapsules; D019819:Budesonide