title: Donor-specific tolerance induction in organ transplantation via mixed splenocytes chimerism.
abstract: We have shown previously that donor-derived splenocytes can replace recipients' bone marrow and induce donor-specific tolerance (DST). We have also shown the usefulness of the chimeric state for the induction of DST. Further analysis of mixed splenocytes chimera, especially the role of each T cells in mixed splenocytes chimera, is indispensable issue for its clinical use. A chimeric state has been shown to achieve long-term survival in major histocompatibility complex (MHC)-mismatched grafts. The donor-derived splenocytes can replace recipients' bone marrow and induce DST. The long-term survival of allogeneic skin grafts was achieved without immunosuppressants. In this study we show the role of each T cell type in a splenocyte mixed chimera. This review provides a short summary of our original work, adding some supplemental interpretations. Mixed chimerism is thus considered an attractive approach for the induction of DST without the use of immunosuppressants. In this paper, we summarize some of the findings on mixed splenocyte chimeras and review mixed chimerism in recent organ transplantation.
authors: Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan. yamazaki-nmed@umin.ac.jp
authors: S
authors: S
authors: Yamazaki
authors: A
authors: A
authors: Kanamoto
authors: T
authors: T
authors: Takayama
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D046528:Chimerism; D006649:Histocompatibility Antigens / Q000378:metabolism; D006801:Humans; D051379:Mice; D016377:Organ Transplantation; D013154:Spleen / Q000276:immunology*; D014019:Tissue Donors; D023001:Transplantation Tolerance
chemical_list: D006649:Histocompatibility Antigens
keywords: bone marrow; chimerism; donor-specific tolerance; skin graft; splenocyte
references: Am J Transplant. 2004 Dec;4(12):2118-25
references: 15575917
references: J Exp Med. 1989 Feb 1;169(2):493-502
references: 2562984
references: J Immunol. 2004 Feb 1;172(3):1444-8
references: 14734720
references: Lancet. 1992 Jun 27;339(8809):1579-82
references: 1351558
references: Transplantation. 1999 Dec 15;68(11):1767-75
references: 10609955
references: Transplantation. 1991 Jan;51(1):70-5
references: 1987708
references: Transplantation. 2004 Sep 27;78(6):825-30
references: 15385800
references: Nature. 1953 Oct 3;172(4379):603-6
references: 13099277
references: Surg Forum. 1969;20:374-6
references: 4192216
references: Bone Marrow Transplant. 1992 Mar;9(3):191-7
references: 1387333
references: Transpl Immunol. 2002 Jun;10(1):37-41
references: 12182463
references: J Immunol. 2001 Sep 15;167(6):3043-8
references: 11544287
references: Dig Liver Dis. 2012 Dec;44(12):988-94
references: 22954489
references: Transplantation. 1993 Jun;55(6):1382-9
references: 8100092
references: Immunol Rev. 2001 Aug;182:18-32
references: 11722621
references: J Immunol. 1995 Aug 1;155(3):1151-64
references: 7636184
references: Transplantation. 1987 May;43(5):641-7
references: 3554655
references: Transplantation. 2007 Nov 15;84(9):1168-73
references: 17998873
references: N Engl J Med. 2008 Jan 24;358(4):353-61
references: 18216355
references: Ann Surg. 1999 Sep;230(3):372-9; discussion 379-81
references: 10493484
references: J Surg Res. 2012 Nov;178(1):133-8
references: 22502904
references: Transplantation. 1991 Jun;51(6):1262-7
references: 1828637
references: Transplantation. 1998 Jul 15;66(1):59-66
references: 9679823
references: J Surg Res. 2012 Jun 1;175(1):62-6
references: 21470627
references: Am J Transplant. 2005 Jun;5(6):1237-47
references: 15888027
references: Clin Exp Nephrol. 2005 Jun;9(2):164-9
references: 15980953
references: N Engl J Med. 1998 Jun 11;338(24):1741-51
references: 9624195
references: Science. 2003 Apr 11;300(5617):339-42
references: 12690202
references: Immunol Rev. 2001 Aug;182:58-67
references: 11722623
references: Am J Transplant. 2004 Sep;4(9):1391-8
references: 15307826
references: Nature. 2005 Mar 3;434(7029):88-93
references: 15744305
references: Transplantation. 2009 Dec 15;88(11):1312-8
references: 19996931
references: Science. 2003 Apr 11;300(5617):337-9
references: 12690201
references: Blood. 2002 May 15;99(10):3493-9
references: 11986199