title: [Epidermal thickness and keratinocyte proliferation after cutaneous application of vitamin D].
abstract: Using light microscopy, morphometry and immunohistochemistry, the epidermis of 72 male and female rats was examined 1 day and 1 month after the completion of daily cutaneous applications of vitamin D3-containing composition lasting for two weeks. It was found that vitamin D3 causes a statistically significant reduction in the thickness of interfollicular epidermis and in the number of Ki-67 positive keratinocytes. The identified effects persisted for 1 month after the last application of the preparation. Modifying influence of vitamin D3 on the morphogenetic processes in the epidermis, which were manifested, in particular, by a decreased proliferative activity of keratinocytes, is discussed in the light of the data on the possibility of the formation of its active metabolite--calcitriol--directly in the skin.
authors: Medical Institute of Oryol State University, Oryol, Russia
authors: S A
authors: SA
authors: Zhuchkov
authors: T A
authors: TA
authors: Belousova
authors: V I
authors: VI
authors: Nosdrin
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects*; D005260:Female; D015603:Keratinocytes / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D051381:Rats; D014807:Vitamin D / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D019394:Ki-67 Antigen; D014807:Vitamin D