title: Computational aspects in mechanical modeling of the articular cartilage tissue.
abstract: This review focuses on the modeling of articular cartilage (at the tissue level), chondrocyte mechanobiology (at the cell level) and a combination of both in a multiscale computation scheme. The primary objective is to evaluate the advantages and disadvantages of conventional models implemented to study the mechanics of the articular cartilage tissue and chondrocytes. From monophasic material models as the simplest form to more complicated multiscale theories, these approaches have been frequently used to model articular cartilage and have contributed significantly to modeling joint mechanics, addressing and resolving numerous issues regarding cartilage mechanics and function. It should be noted that attentiveness is important when using different modeling approaches, as the choice of the model limits the applications available. In this review, we discuss the conventional models applicable to some of the mechanical aspects of articular cartilage such as lubrication, swelling pressure and chondrocyte mechanics and address some of the issues associated with the current modeling approaches. We then suggest future pathways for a more realistic modeling strategy as applied for the simulation of the mechanics of the cartilage tissue using multiscale and parallelized finite element method.
authors: School of Engineering, Faculty of Applied Science, The University of British Columbia, Okanagan Campus, Kelowna, British Columbia, Canada. hadim74@gmail.com
authors: Hadi
authors: H
authors: Mohammadi
authors: Kibret
authors: K
authors: Mequanint
authors: Walter
authors: W
authors: Herzog
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002356:Cartilage / Q000473:pathology; D002358:Cartilage, Articular / Q000166:cytology / Q000473:pathology*; D019902:Chondrocytes / Q000166:cytology / Q000473:pathology; D002809:Chondroitin Sulfates / Q000737:chemistry; D019245:Compressive Strength; D003198:Computer Simulation; D020342:Finite Element Analysis; D006801:Humans; D007632:Keratan Sulfate / Q000737:chemistry; D007719:Knee Joint / Q000473:pathology; D008954:Models, Biological; D015233:Models, Statistical; D008962:Models, Theoretical; D016062:Porosity; D013314:Stress, Mechanical; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D002809:Chondroitin Sulfates; D007632:Keratan Sulfate
keywords: Articular cartilage; cartilage mechanics; chondrocyte mechanobiology; computational mechanics; continuum model; finite element method; large deformation theory; numerical modeling