title: Abnormal ghrelin secretion contributes to gastrointestinal symptoms in multiple system atrophy patients.
abstract: Patients with multiple system atrophy (MSA) often have evidence of compromised gastrointestinal motility. Ghrelin is a gut hormone that influences gastrointestinal motility in humans. The aim of this study was to determine whether ghrelin secretion is affected in MSA patients, and to investigate the relation between ghrelin secretion and gastrointestinal symptoms. Plasma levels of active ghrelin and unacylated ghrelin were measured in patients with MSA (n = 30), other atypical parkinsonian disorders including progressive supranuclear palsy-Richardson syndrome and corticobasal syndrome (n = 24), and control subjects (n = 24) using enzyme-linked immunosorbent assays. Gastrointestinal symptoms were quantified in all subjects using a self-report questionnaire. The ratio of active ghrelin to total ghrelin in the plasma (active ghrelin ratio) was lower in patients with MSA (mean: 8.0 %) than in patients with other atypical parkinsonian disorders (mean: 13.7 %, P = 0.001) and control subjects (mean: 13.9 %, P = 0.001). The active ghrelin ratio was correlated with the severity of gastrointestinal symptoms in MSA (r = -0.5, P = 0.004). Our observations indicate that ghrelin secretion is affected in patients with MSA. The low active ghrelin ratio may contribute to gastrointestinal symptoms in MSA.
authors: Department of Neurology, Brain Research Institute, Niigata University, 1 Asahimachi-dori Chuoku, Niigata 951-8585, Japan. ozawa@bri.niigata-u.ac.jp
authors: Tetsutaro
authors: T
authors: Ozawa
authors: Jun
authors: J
authors: Tokunaga
authors: Musashi
authors: M
authors: Arakawa
authors: Atsushi
authors: A
authors: Ishikawa
authors: Ryoko
authors: R
authors: Takeuchi
authors: Naomi
authors: N
authors: Mezaki
authors: Takeshi
authors: T
authors: Miura
authors: Naoko
authors: N
authors: Sakai
authors: Mariko
authors: M
authors: Hokari
authors: Akari
authors: A
authors: Takeshima
authors: Kota
authors: K
authors: Utsumi
authors: Takashi
authors: T
authors: Kondo
authors: Akio
authors: A
authors: Yokoseki
authors: Masatoyo
authors: M
authors: Nishizawa
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001342:Autonomic Nervous System Diseases / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism*; D054439:Ghrelin / Q000097:blood / Q000378:metabolism*; D006728:Hormones / Q000097:blood; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D019578:Multiple System Atrophy / Q000150:complications* / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D000978:Antiparkinson Agents; D054439:Ghrelin; D006728:Hormones; D007980:Levodopa
references: Neurology. 1996 Jul;47(1):1-9
references: 8710059
references: J Sleep Res. 2008 Sep;17(3):331-4
references: 18564298
references: Peptides. 2011 Nov;32(11):2348-51
references: 21835213
references: Clin Endocrinol (Oxf). 2002 Oct;57(4):539-46
references: 12354137
references: Gut. 2006 Mar;55(3):327-33
references: 16216827
references: J Physiol. 2006 Oct 1;576(Pt 1):329-38
references: 16873401
references: J Neurol. 2012 Jul;259(7):1448-52
references: 22218651
references: Ann Neurol. 2003;54 Suppl 5:S15-9
references: 12833363
references: Mov Disord. 2004 Aug;19(8):924-9
references: 15300657
references: Neurogastroenterol Motil. 2010 Oct;22(10):1124-31
references: 20584261
references: Psychoneuroendocrinology. 2005 Jan;30(1):106-10
references: 15358448
references: Neurology. 2006 Feb 14;66(3):378-83
references: 16476936
references: Eur J Endocrinol. 2005 May;152(5):743-7
references: 15879360
references: Eur J Endocrinol. 2005 Oct;153(4):545-9
references: 16189176
references: J Clin Endocrinol Metab. 2004 Aug;89(8):3988-93
references: 15292338
references: J Clin Endocrinol Metab. 2006 Sep;91(9):3296-302
references: 16772353
references: Neurology. 2008 Aug 26;71(9):670-6
references: 18725592
references: Parkinsonism Relat Disord. 2012 Mar;18(3):290-3
references: 22119504
references: Nature. 1999 Dec 9;402(6762):656-60
references: 10604470
references: J Clin Endocrinol Metab. 2004 Sep;89(9):4729-33
references: 15356087
references: Endocrinology. 2011 Jul;152(7):2619-25
references: 21521750
references: J Endocrinol Invest. 2003 Jul;26(7):629-34
references: 14594113
references: Hepatogastroenterology. 2012 Jan-Feb;59(113):62-6
references: 22260823
references: J Endocrinol Invest. 2001 Jun;24(6):RC19-21
references: 11434675
references: Mov Disord. 2004 Nov;19(11):1306-12
references: 15390007