title: Portal Hypertension in Childhood Bilateral Wilms' Tumor Survivor: An Excellent Indication for TIPS.
abstract: Introduction. Increased pressure in portal venous system is relatively a rare complication after chemoradiotherapy for Wilms' tumor (WT). In paediatric population, feasibility and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) in portal hypertension nonresponsive to medical or endoscopic treatment have been recently advocated. We report a case of TIPS positioning in a 15-year-old girl with portal hypertension as a long-term sequel of multimodality therapy in bilateral WT. Case Report. Two-year-old girl was diagnosed for bilateral WT. Right nephrectomy with left heminephrectomy and chemoradiotherapy were performed. At 7 years of age, the first gastrointestinal bleeding appeared, followed by another episode two years later, both were treated successfully with beta-blockers. At 15 years of age, severe unresponsive life-threatening gastroesophageal bleeding without hepatosplenomegaly was managed by TIPS. Reduction of the portosystemic pressure gradient was obtained. Conclusion. TIPS positioning for portal hypertension in long-term tumors' sequel is feasible and could be considered as an additional indication in paediatric patients.
authors: Department of the Mother and Child Health, Pediatric Surgery Unit, IRCCS Policlinico San Matteo Foundation and University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy.
authors: Ghassan
authors: G
authors: Nakib
authors: Valeria
authors: V
authors: Calcaterra
authors: Marco
authors: M
authors: Brunero
authors: Ilaria
authors: I
authors: Goruppi
authors: Pietro
authors: P
authors: Quaretti
authors: Lorenzo Paolo
authors: LP
authors: Moramarco
authors: Raffaele
authors: R
authors: Bruno
authors: Alessandro
authors: A
authors: Raffaele
authors: Gloria
authors: G
authors: Pelizzo
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