title: Solvent-free methallylboration of ketones accelerated by tert-alcohols.
abstract: A solvent- and metal-free process has been developed for the direct methallylboration of ketones employing the stable B-methallylborinane 1, which was accelerated by tertiary alcohols. In the presence of 2.0 equiv of readily available tertiary alcohols such as tert-amyl alcohol, the methallylation products were prepared at room temperature in excellent yields. The salient features of the described process include simple operation, high efficiency, and mild reaction conditions.
authors: Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877-0368, United States. yongda.zhang@boehringer-ingelheim.com
authors: Yongda
authors: Y
authors: Zhang
authors: Ning
authors: N
authors: Li
authors: Navneet
authors: N
authors: Goyal
authors: Guisheng
authors: G
authors: Li
authors: Heewon
authors: H
authors: Lee
authors: Bruce Z
authors: BZ
authors: Lu
authors: Chris H
authors: CH
authors: Senanayake
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry*; D001880:Boranes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000438:Alcohols; D001880:Boranes; D007659:Ketones