title: Vessel-encoded arterial spin labeling (VE-ASL) reveals elevated flow territory asymmetry in older adults with substandard verbal memory performance.
abstract: OBJECTIVE
  To evaluate how flow territory asymmetry and/or the distribution of blood through collateral pathways may adversely affect the brain's ability to respond to age-related changes in brain function. These patterns have been investigated in cerebrovascular disease; however, here we evaluated how flow-territory asymmetry related to memory generally in older adults.
  
  
  METHODS
  A multi-faceted MRI protocol, including vessel-encoded arterial spin labeling capable of flow territory mapping, was applied to assess how flow territory asymmetry; memory performance (CERAD-Immediate Recall); cortical cerebral blood flow (CBF), white matter lesion (WML) count, and cortical gray matter volume were related in older healthy control volunteers (HC; n = 15; age = 64.5 ± 7 years) and age-matched mild cognitive impairment volunteers (MCI; n = 7; age = 62.7 ± 3.7 years).
  
  
  RESULTS
  An inverse relationship was found between memory performance and flow territory asymmetry in HC volunteers (P = 0.04), which reversed in MCI volunteers (P = 0.04). No relationship was found between memory performance and cortical tissue volume in either group (P > 0.05). Group-level differences for HC volunteers performing above versus below average on CERAD-I were observed for flow territory asymmetry (P < 0.02) and cortical volume (P < 0.05) only.
  
  
  CONCLUSIONS
  Findings suggest that flow territory asymmetry may correlate more sensitively with memory performance than CBF, atrophy and WML count in older adults.
authors: Vanderbilt University Institute of Imaging Science, Nashville, Tennessee, USA; Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA; Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Neurology, Vanderbilt School of Medicine, Nashville, Tennessee, USA; Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, USA.
authors: Manus J
authors: MJ
authors: Donahue
authors: Erin
authors: E
authors: Hussey
authors: Swati
authors: S
authors: Rane
authors: Tracy
authors: T
authors: Wilson
authors: Matthias
authors: M
authors: van Osch
authors: Nolan
authors: N
authors: Hartkamp
authors: Jeroen
authors: J
authors: Hendrikse
authors: Brandon A
authors: BA
authors: Ally
mesh_terms: D000328:Adult; D000375:Aging / Q000473:pathology; D001783:Blood Flow Velocity; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D002533:Cerebral Angiography / Q000379:methods; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D008568:Memory; D008569:Memory Disorders / Q000503:physiopathology*; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels; D014705:Verbal Behavior
chemical_list: D013113:Spin Labels
keywords: ageing; cerebral blood flow; dementia; flow territory asymmetry; memory; vessel encoded arterial spin labeling (VE-ASL)
references: J Neurol. 2011 Nov;258(11):2036-42
references: 21544565
references: Neurobiol Aging. 2012 Jan;33(1):75-82
references: 20359779
references: Magn Reson Med. 2010 May;63(5):1357-65
references: 20432306
references: J Vasc Surg. 2007 Jun;45(6):1155-61
references: 17543680
references: Hippocampus. 2013 Mar;23(3):213-20
references: 23109214
references: Ann Neurol. 2011 Jun;69(6):963-74
references: 21437932
references: Neuroimage. 2002 Oct;17(2):825-41
references: 12377157
references: Mov Disord. 2012 Aug;27(9):1169-72
references: 22692677
references: J Cereb Blood Flow Metab. 2012 Jul;32(7):1177-87
references: 22373642
references: Ann Neurol. 2010 Dec;68(6):865-75
references: 21194156
references: J Neurol. 2010 Sep;257(9):1565
references: 20339861
references: Circulation. 2011 May 3;123(17):1900-10
references: 21537006
references: AJNR Am J Neuroradiol. 2012 Feb;33(2):E21-5
references: 21393410
references: Stroke. 2012 Mar;43(3):903-15
references: 22343644
references: Philos Trans R Soc Lond B Biol Sci. 1997 Nov 29;352(1362):1703-9
references: 9415922
references: Epilepsia. 2004 May;45(5):551-4
references: 15101837
references: Psychopharmacol Bull. 1988;24(4):641-52
references: 3249766
references: Neurology. 1997 May;48(5):1473-4
references: 9153504
references: J Magn Reson Imaging. 2013 Nov;38(5):1129-39
references: 23440909
references: Magn Reson Med. 2010 Sep;64(3):777-86
references: 20597127
references: Lancet. 2003 Feb 15;361(9357):605-8
references: 12598159
references: Ann N Y Acad Sci. 1997 Sep 26;826:25-34
references: 9329678
references: N Engl J Med. 2001 Nov 22;345(21):1515-21
references: 11794217
references: Arch Neurol. 1976 Aug;33(8):523-6
references: 942309
references: Neurology. 2004 Oct 26;63(8):1452-6
references: 15505164
references: Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
references: 10984517
references: Magn Reson Med. 2010 Mar;63(3):641-7
references: 20146233
references: J Cereb Blood Flow Metab. 2009 Dec;29(12):1867-78
references: 19724286
references: Biol Pharm Bull. 2000 Jun;23(6):735-7
references: 10864026
references: Neurosurgery. 2005 Sep;57(3):486-94; discussion 486-94
references: 16145527
references: Stroke. 2003 Sep;34(9):2279-84
references: 12881609
references: Magn Reson Med. 2006 Jun;55(6):1334-41
references: 16700025
references: Neurology. 1988 Oct;38(10):1565-8
references: 3419600
references: Neurology. 1977 Oct;27(10):905-10
references: 561903
references: Lancet Neurol. 2004 Mar;3(3):184-90
references: 14980533
references: Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7209-14
references: 19357304
references: Cerebrovasc Brain Metab Rev. 1992 Spring;4(1):1-27
references: 1562450
references: Stroke. 2004 Apr;35(4):882-7
references: 14988567
references: Neuroimage. 2005 May 1;25(4):1325-35
references: 15850749
references: J Neurol Sci. 2007 Mar 15;254(1-2):49-53
references: 17275849
references: J Anat. 1991 Jun;176:45-54
references: 1917674
references: Neuroimage. 2011 Jan 1;54(1):602-10
references: 20705142
references: Cerebrovasc Dis. 2006;22(4):217-24
references: 16788293