title: Pulse wave velocity and cognitive function in older adults.
abstract: Arterial stiffness may be associated with cognitive function. In this study, pulse wave velocity (PWV) was measured from the carotid to femoral (CF-PWV) and from the carotid to radial (CR-PWV) with the Complior SP System. Cognitive function was measured by 6 tests of executive function, psychomotor speed, memory, and language fluency. A total of 1433 participants were included (mean age 75 y, 43% men). Adjusting for age, sex, education, pulse rate, hemoglobin A1C, high-density lipoprotein cholesterol, hypertension, cardiovascular disease history, smoking, drinking, and depression symptoms, a CF-PWV>12 m/s was associated with a lower Mini-Mental State Examination score (coefficient: -0.31, SE: 0.11, P=0.005), fewer words recalled on Auditory Verbal Learning Test (coefficient: -1.10, SE: 0.43, P=0.01), and lower score on the composite cognition score (coefficient: -0.10, SE: 0.05, P=0.04) and marginally significantly associated with longer time to complete Trail Making Test-part B (coefficient: 6.30, SE: 3.41, P=0.06), CF-PWV was not associated with Trail Making Test-part A, Digit Symbol Substation Test, or Verbal Fluency Test. No associations were found between CR-PWV and cognitive performance measures. Higher large artery stiffness was associated with worse cognitive function, and longitudinal studies are needed to confirm these associations.
authors: Department of Population Health Sciences, University of Wisconsin-Madison, WI.
authors: Wenjun
authors: W
authors: Zhong
authors: Karen J
authors: KJ
authors: Cruickshanks
authors: Carla R
authors: CR
authors: Schubert
authors: Cynthia M
authors: CM
authors: Carlsson
authors: Richard J
authors: RJ
authors: Chappell
authors: Barbara E K
authors: BE
authors: Klein
authors: Ronald
authors: R
authors: Klein
authors: Charles W
authors: CW
authors: Acher
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D025341:Principal Component Analysis; D063177:Pulse Wave Analysis; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology*
references: Am J Hypertens. 2009 May;22(5):525-30
references: 19265790
references: Age Ageing. 2008 Nov;37(6):653-9
references: 18703522
references: Am J Hypertens. 2002 Aug;15(8):743-53
references: 12160200
references: J Hypertens. 2007 Jun;25(6):1105-87
references: 17563527
references: Brain. 2011 Nov;134(Pt 11):3398-407
references: 22075523
references: J Physiol. 2009 Dec 1;587(Pt 23):5541-9
references: 19723776
references: Stroke. 2007 Mar;38(3):888-92
references: 17272780
references: Clin Physiol Funct Imaging. 2007 May;27(3):191-6
references: 17445071
references: Curr Vasc Pharmacol. 2010 Sep;8(5):638-44
references: 20507272
references: Stroke. 2005 Oct;36(10):2193-7
references: 16151027
references: Arch Gerontol Geriatr. 2009 Jul-Aug;49(1):176-9
references: 18786736
references: Hypertension. 2009 Apr;53(4):668-73
references: 19237680
references: J Gerontol A Biol Sci Med Sci. 2005 May;60(5):607-12
references: 15972613
references: Stroke. 2011 Sep;42(9):2672-713
references: 21778438
references: Hypertension. 2005 Jul;46(1):200-4
references: 15911742
references: J Psychiatr Res. 1975 Nov;12(3):189-98
references: 1202204
references: J Gerontol A Biol Sci Med Sci. 2011 Dec;66(12):1336-42
references: 21768503
references: Hypertension. 1995 Sep;26(3):485-90
references: 7649586
references: Eur Radiol. 2010 May;20(5):1132-8
references: 19915847
references: Am J Epidemiol. 1998 Nov 1;148(9):879-86
references: 9801018
references: Hypertens Res. 2008 Jan;31(1):75-81
references: 18360021
references: Arch Neurol. 2003 Aug;60(8):1119-22
references: 12925369
references: J Am Coll Cardiol. 2010 Mar 30;55(13):1318-27
references: 20338492
references: J Hypertens. 2006 Jul;24(7):1231-7
references: 16794467
references: J Hypertens. 2007 May;25(5):1035-40
references: 17414668
references: Am J Hypertens. 2010 Dec;23(12):1265-72
references: 20671719
references: J Am Med Dir Assoc. 2012 Mar;13(3):239-43
references: 21450208
references: J Hypertens. 2002 Sep;20(9):1707-9
references: 12195105
references: Am J Cardiovasc Drugs. 2001;1(5):387-97
references: 14728020
references: Prev Med. 1976 Jun;5(2):207-15
references: 935073
references: Hypertension. 1999 May;33(5):1111-7
references: 10334796
references: Eur Heart J. 2006 Nov;27(21):2588-605
references: 17000623
references: Stroke. 2003 Mar;34(3):806-12
references: 12624314
references: Hypertension. 2008 Jan;51(1):99-104
references: 18025297