title: Food restriction-induced autophagy modulates degradation of mutant SOD1 in an amyotrophic lateral sclerosis mouse model.
abstract: Autophagy dysregulation has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). The expression of LC3II and sequestosome 1 (P62) was progressively increased in the lumbar spinal cord of ALS mice. However, whether autophagy is activated or inhibited is still unclear. By treating mice with food restriction, a well-recognized way to induce autophagy, we found that 48 h of food restriction significantly reduced p62 and mutated SOD1 expressions at onset stage but not at pre-end stage in the spinal cord of SOD1-G93A mice. These data indicate that activating autophagy at a certain disease stage may have potential protective effects on ALS.
authors: Department of Neurology, the Second Hospital of Hebei Medical University, 215 Heping West Road, Shijiazhuang, Hebei Province, 050000, China.
authors: Kunxi
authors: K
authors: Zhang
authors: Pengxiao
authors: P
authors: Shi
authors: Ting
authors: T
authors: An
authors: Qian
authors: Q
authors: Wang
authors: Jingjing
authors: J
authors: Wang
authors: Zhongyao
authors: Z
authors: Li
authors: Weisong
authors: W
authors: Duan
authors: Chunyan
authors: C
authors: Li
authors: Yansu
authors: Y
authors: Guo
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000473:pathology / Q000628:therapy; D000704:Analysis of Variance; D000818:Animals; D001343:Autophagy / Q000502:physiology*; D004195:Disease Models, Animal; D005508:Food Deprivation / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000378:metabolism; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D018613:Microscopy, Confocal; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D000071456:Sequestosome-1 Protein; D013116:Spinal Cord / Q000473:pathology*; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism; D013997:Time Factors; D050995:Voltage-Dependent Anion Channel 1 / Q000378:metabolism
chemical_list: D006360:Heat-Shock Proteins; D008869:Microtubule-Associated Proteins; D012333:RNA, Messenger; D000071456:Sequestosome-1 Protein; D013482:Superoxide Dismutase; D050995:Voltage-Dependent Anion Channel 1; C526109:Anxa3 protein, rat; C491079:Sqstm1 protein, rat; C109415:SOD1 G93A protein