title: Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking.
abstract: Addiction to cocaine produces long-lasting, stable changes in brain synaptic physiology that might contribute to the vulnerability to relapse. In humans, exposure to environmental contexts previously paired with drug use precipitates relapse, but the neurobiological mechanisms mediating this process are unknown. Initiation of cocaine relapse via re-exposure to a drug-associated context elicited reinstatement of cocaine seeking as well as rapid, transient synaptic plasticity in the nucleus accumbens core (NAcore), measured as an increase in dendritic spine diameter. These results show that rapid context-evoked synaptic potentiation in the NAcore may underpin relapse to cocaine use.
authors: Department of Biology, College of Charleston, Charleston, SC, USA; Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA.
authors: Neringa M
authors: NM
authors: Stankeviciute
authors: Michael D
authors: MD
authors: Scofield
authors: Peter W
authors: PW
authors: Kalivas
authors: Cassandra D
authors: CD
authors: Gipson
mesh_terms: D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000473:pathology / Q000503:physiopathology*; D003463:Cues; D049229:Dendritic Spines / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D058999:Drug-Seeking Behavior / Q000187:drug effects; D005108:Extinction, Psychological / Q000187:drug effects; D017774:Long-Term Potentiation / Q000187:drug effects; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D012008:Recurrence; D012054:Reinforcement, Psychology; D012646:Self Administration
chemical_list: D018765:Dopamine Uptake Inhibitors; D003042:Cocaine
keywords: Cocaine; context-induced relapse; dendritic spines; nucleus accumbens core; synaptic potentiation
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