title: Inhibitory activities of Ulva lactuca polysaccharides on digestive enzymes related to diabetes and obesity.
abstract: The aim of this study was to evaluate the effect of alga Ulva lactuca polysaccharides (ULPS) on key enzymes related to diabetes and obesity. This marine natural product, ULPS, exerted potential inhibition on key enzymes related to starch digestion and absorption in both plasma and small intestine mainly α-amylase by 53% and 34% and maltase by 97 and 164% respectively, leading to a significant decrease in blood glucose rate by 297%. Moreover, ULPS potentially inhibited key enzymes of lipid metabolism and absorption as lipase activity in both plasma and small intestine by 235 and 287% respectively, which led to a notable decrease of blood LDL-cholesterol and triglycerides levels, and in the counterpart an increase in HDL-cholesterol level in surviving diabetic rats. Additively, ULPS significantly protected the liver-kidney functions, by decreasing of aspartate transaminase (AST), alanine transaminase (ALT) and gamma-glytamyl transpeptidase (GGT) activities and creatinine, urea and albumin rates in plasma.
authors: Laboratory of Animal Ecophysiology, University of Sfax, Faculty of Sciences of Sfax, PO Box 95, Sfax, Tunisia.
authors: Sahla
authors: S
authors: BelHadj
authors: Olfa
authors: O
authors: Hentati
authors: Abdelfattah
authors: A
authors: Elfeki
authors: Khaled
authors: K
authors: Hamden
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D008078:Cholesterol, LDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology* / Q000503:physiopathology; D004063:Digestion / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D065089:Glycoside Hydrolase Inhibitors; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000201:enzymology; D007668:Kidney / Q000503:physiopathology; D008049:Lipase / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000201:enzymology / Q000503:physiopathology; D008297:Male; D009765:Obesity / Q000201:enzymology* / Q000503:physiopathology; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013213:Starch / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D044445:Ulva / Q000737:chemistry*; D000516:alpha-Amylases / Q000037:antagonists & inhibitors
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D011134:Polysaccharides; D014280:Triglycerides; D013213:Starch; D008049:Lipase; D000516:alpha-Amylases