title: Collagen triple helix repeat containing-1 (CTHRC1) expression in invasive ductal carcinoma of the breast: the impact on prognosis and correlation to clinicopathologic features.
abstract: CTHRC1 has been known as a regulator of collagen expression and cell migration. The aim of this research was to clarify the clinicopathologic significance of CTHRC1 expression in human breast cancer. 22 cases of breast cancer tissues, randomly selected from clinically diagnosed patients, showed a significant increase of CTHRC1 mRNA expression compared to the normal tissue from the same patients using RT-PCR and real-time PCR. Additionally we investigated breast cancers from 189 patients by immunohistochemistry (IHC). A high level of CTHRC1 expression was observed in 111 (58.7 %) out of 189 breast cancer patients and the expression was significantly correlated with histologic grade (P = 0.026), nodal status (P < 0.001), and TNM pathologic stage (P = 0.002). High CTHRC1 expression was associated with a shorter recurrence free survival (P = 0.008). Taken together, the results showed that CTHRC1 over-expression was significantly associated with clinicopathological factors of poor prognosis in invasive ductal carcinoma. CTHRC1 could be used as a supplementary prognostic biomarker and a potential therapeutic target in breast cancer.
authors: Department of Pathology, Eulji University School of Medicine, Daejeon, 301-070, Republic of Korea.
authors: Joo Heon
authors: JH
authors: Kim
authors: Tae-Hwa
authors: TH
authors: Baek
authors: Hyun Sun
authors: HS
authors: Yim
authors: Kyo Hyun
authors: KH
authors: Kim
authors: Seong-Hoo
authors: SH
authors: Jeong
authors: Ho Bum
authors: HB
authors: Kang
authors: Sang-Seok
authors: SS
authors: Oh
authors: Hee Gu
authors: HG
authors: Lee
authors: Jae Wha
authors: JW
authors: Kim
authors: Kwang Dong
authors: KD
authors: Kim
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis
chemical_list: C502426:CTHRC1 protein, human; D016326:Extracellular Matrix Proteins
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