title: Deciphering the role of CA1 inhibitory circuits in sharp wave-ripple complexes.
abstract: Sharp wave-ripples (SWRs) are population oscillatory patterns in hippocampal LFPs during deep sleep and immobility, involved in the replay of memories acquired during wakefulness. SWRs have been extensively studied, but their exact generation mechanism is still unknown. A computational model has suggested that fast perisomatic inhibition may generate the high frequency ripples (~200 Hz). Another model showed how replay of memories can be controlled by various classes of inhibitory interneurons targeting specific parts of pyramidal cells (PC) and firing at particular SWR phases. Optogenetic studies revealed new roles for interneuronal classes and rich dynamic interplays between them, shedding new light in their potential role in SWRs. Here, we integrate these findings in a conceptual model of how dendritic and somatic inhibition may collectively contribute to the SWR generation. We suggest that sharp wave excitation and basket cell (BC) recurrent inhibition synchronises BC spiking in ripple frequencies. This rhythm is imposed on bistratified cells which prevent pyramidal bursting. Axo-axonic and stratum lacunosum/moleculare interneurons are silenced by inhibitory inputs originating in the medial septum. PCs receiving rippling inhibition in both dendritic and perisomatic areas and excitation in their apical dendrites, exhibit sparse ripple phase-locked spiking.
authors: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas Heraklion, Greece.
authors: Vassilis
authors: V
authors: Cutsuridis
authors: Jiannis
authors: J
authors: Taxidis
keywords: hippocampus; inhibition; medial septum; memory consolidation; sharp wave-ripple complexes
references: J Neurosci. 1999 Jul 15;19(14):6191-9
references: 10407055
references: Front Neurosci. 2012 Nov 14;6:165
references: 23162426
references: Neuron. 2008 Mar 27;57(6):917-29
references: 18367092
references: Hippocampus. 2012 May;22(5):995-1017
references: 21452258
references: J Physiol. 2011 Apr 15;589(Pt 8):1875-83
references: 21135049
references: Neuroscience. 1989;31(3):571-91
references: 2687721
references: Neuron. 2000 Nov;28(2):585-94
references: 11144366
references: Nature. 2011 Jan 20;469(7330):397-401
references: 21179088
references: Science. 1996 Mar 29;271(5257):1870-3
references: 8596957
references: Neuroscience. 1989;31(3):551-70
references: 2687720
references: Science. 2008 Jul 4;321(5885):53-7
references: 18599766
references: Nat Neurosci. 2007 Oct;10(10):1241-2
references: 17828259
references: Hippocampus. 1996;6(4):347-470
references: 8915675
references: Nat Neurosci. 2009 Jul;12(7):919-26
references: 19483687
references: J Neurosci. 2012 Aug 22;32(34):11798-811
references: 22915121
references: Neural Netw. 2009 Oct;22(8):1120-8
references: 19647982
references: Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4398-403
references: 23440221
references: J Neurosci. 2000 Mar 15;20(6):2086-93
references: 10704482
references: Nature. 2006 Mar 30;440(7084):680-3
references: 16474382
references: J Neurosci. 2010 Apr 28;30(17):5979-91
references: 20427657
references: Front Comput Neurosci. 2013 Feb 05;7:3
references: 23386827
references: Nat Neurosci. 2012 Nov;15(11):1524-30
references: 23042082
references: J Neurosci. 1999 Jan 1;19(1):274-87
references: 9870957
references: Nat Neurosci. 2012 Jan 15;15(3):423-30, S1-3
references: 22246433
references: Nature. 1995 Nov 2;378(6552):75-8
references: 7477292
references: Nat Neurosci. 2004 Jan;7(1):41-7
references: 14634650
references: Nat Neurosci. 2012 Sep;15(9):1265-71
references: 22864613
references: Nature. 2003 Feb 20;421(6925):844-8
references: 12594513
references: J Neurosci. 1996 May 1;16(9):3056-66
references: 8622135
references: J Neurosci. 1998 May 15;18(10):3919-28
references: 9570819
references: J Neurosci. 2008 Oct 1;28(40):10017-22
references: 18829959
references: J Physiol. 2005 Jan 1;562(Pt 1):9-26
references: 15539390
references: Nat Neurosci. 2009 Oct;12(10):1222-3
references: 19749750
references: Hippocampus. 2010 Mar;20(3):423-46
references: 19489002
references: Nature. 1988 Nov 10;336(6195):170-3
references: 3185735
references: J Neurosci. 1995 Jan;15(1 Pt 1):30-46
references: 7823136
references: Science. 1992 May 15;256(5059):1025-7
references: 1589772
references: Nat Neurosci. 2012 Mar 25;15(5):769-75
references: 22446878