title: [Thymoma-associated myasthenia gravis: Clinical features and surgical results].
abstract: OBJECTIVE
  The aim of this study was to compare the characteristics of myasthenic patients with and without thymoma, and the results of thymectomy in both types of patients.
  
  
  METHODS
  A retrospective study was conducted among 66 patients who underwent thymectomy for myasthenia gravis in our department over a 10-year period (2000-2010). The surgical approach was sternotomy or anterolateral thoracotomy. Patients were divided into two groups according to the presence of thymoma: with (T-MG) and without (NT-MG) thymoma. Complete stable remission (CSR) was the primary endpoint.
  
  
  RESULTS
  Median age was 35.09±9.89 years. The NT-MG group had 38 patients (57.57%) and the T-MG group 28 patients (42.43%). There was no difference between the two groups regarding the surgical approach (P=0.52). T-MG patients were older (40.54±15.16 vs. 31.37±9.46) (P=0.008) and predominantly male. There were more generalized forms (P=0.01) and more bulbar involvement (P=0.02) in the T-MG group. The rate of CSR at 5 years was 7% and 17% in the T-MG and NT-MG patients respectively (P=0.70). At 10 years, it was 36% and 94.73% respectively (P=0.03).
  
  
  CONCLUSIONS
  Thymomatous myasthenia gravis is characterized by the severity of its clinical features. Remission rate at 10 years was significantly lower in the myasthenia with thymoma group.
authors: Service de chirurgie thoracique, CHU Ibn Sina, BP 353, Rabat principale 10001, Maroc; Centre de recherche en épidémiologie clinique et essais thérapeutiques (CRECET), faculté de médecine et de pharmacie de Rabat, université Mohamed V Souissi, Angle avenue Allal El Fassi et Mfadel Cherkaoui, Al Irfane 8007, N.U, Rabat, Maroc. Electronic address: m.bouchikh@um5s.net.ma.
authors: M
authors: M
authors: Bouchikh
authors: H O
authors: HO
authors: El Malki
authors: F
authors: F
authors: Ouchen
authors: A
authors: A
authors: Achir
authors: A
authors: A
authors: Benosman
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000453:epidemiology / Q000209:etiology* / Q000601:surgery*; D012189:Retrospective Studies; D056346:Sternotomy / Q000706:statistics & numerical data; D013908:Thoracotomy / Q000706:statistics & numerical data; D013934:Thymectomy / Q000379:methods / Q000706:statistics & numerical data; D013945:Thymoma / Q000150:complications* / Q000453:epidemiology / Q000601:surgery*; D013953:Thymus Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000601:surgery*; D016896:Treatment Outcome
keywords: Chirurgie; Complete stable remission; Myasthenia gravis; Myasthénie; Rémission complète et stable; Surgery; Thymectomie; Thymectomy; Thymoma; Thymome