title: 350-μm side-view optical probe for imaging the murine brain in vivo from the cortex to the hypothalamus.
abstract: Miniature endoscopic probes offer a solution for deep brain imaging by overcoming the limited depth of intravital microscopy. We describe a small-diameter (350 μm) graded-index optical probe with a side-view design for in vivo cellular imaging of the mammalian brain. The side-view probe provides a unique view of the vertical network of neurons and penetrating blood vessels. At a given insertion site, the translational and rotational scanning of the probe provides access to a large tissue area (>1  mm(2)) across the cortex, hippocampus, thalamus, and hypothalamus.
authors: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
authors: Jun Ki
authors: JK
authors: Kim
authors: Jin Woo
authors: JW
authors: Choi
authors: Seok Hyun
authors: SH
authors: Yun
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000473:pathology; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D002560:Cerebrovascular Circulation; D019723:Endoscopes; D006651:Histocytochemistry; D007031:Hypothalamus / Q000033:anatomy & histology*; D051379:Mice; D008822:Mice, Transgenic; D008904:Miniaturization / Q000295:instrumentation*; D059906:Neuroimaging / Q000295:instrumentation*