title: Targeting IL-15 in large granular lymphocyte leukemia.
abstract: IL-15 is a cytokine that stimulates the proliferation of NK and T cells. Previous studies have shown that IL-15 is critical to the induction of T-cell large granular lymphocyte (T-LGL) leukemia. A Phase I trial of a humanized antibody (Hu-Mikβ1) to the IL2/IL15Rβ receptor, expressed on T-LGL, is explored in this trial to evaluate the safety, pharmacokinetics, specificity and clinical efficacy of Hu-Mikβ1. The study demonstrated no toxicity and favorable saturation of IL2/IL15Rβ receptor, but no clinical efficacy in this Phase I study.
authors: Penn State Hershey Cancer Institute, 500 University Drive, Hershey, PA 17033, USA.
authors: Steven N
authors: SN
authors: Steinway
authors: Thomas P
authors: TP
authors: Loughran
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