title: Spontaneous and mitogen-induced cytokine production in lymphoproliferative diseases.
abstract: The levels of spontaneous and mitogen-induced production of pro- and anti-inflammatory cytokines were studied in patients with chronic lymphoid leukemia, non-Hodgkin's lymphocytic lymphomas, and multiple myeloma during the course of chemotherapy. Cytokine concentrations varied within a great range and did not conform to the normal distribution law. The levels of granulocyte and granulocyte-macrophage CSF were high during the debut, progress, and remission of the lymphoproliferative diseases. Imbalance of a wide spectrum of pro- and anti-inflammatory cytokines was observed during the debut and progress of the lymphoproliferative diseases, more often in chronic lymphoid leukemia and non-Hodgkin's lymphocytic lymphomas than in multiple myeloma.
authors: Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Russia. pathol@soramn.ru
authors: N P
authors: NP
authors: Domnikova
authors: T Yu
authors: TY
authors: Dolgikh
authors: Yu A
authors: YA
authors: D'yachkova
authors: E E
authors: EE
authors: Petrusenko
authors: T B
authors: TB
authors: Kuznetsova
authors: O V
authors: OV
authors: Reshetnikov
authors: S L
authors: SL
authors: Ryzhikova
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007945:Leukemia, Lymphoid / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D009101:Multiple Myeloma / Q000097:blood* / Q000188:drug therapy / Q000276:immunology
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D008070:Lipopolysaccharides; D008934:Mitogens; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor