title: [Physico-chemical features of dinitrosyl iron complexes with natural thiol-containing ligands underlying biological activities of these complexes].
abstract: Current notions and new experimental data of the authors on physico-chemical features of dinitrosyl iron complexes with natural thiol-containing ligands (glutathione or cysteine), underlying the ability of the complexes to act as NO molecule and nitrosonium ion donors, are considered. This ability determines various biological activities of dinitrosyl iron complexes--inducing long-lasting vasodilation and thereby long-lasting hypotension in human and animals, inhibiting pellet aggregation, increasing red blood cell elasticity, thereby stimulating microcirculation, and reducing necrotic zone in animals with myocardial infarction. Moreover, dinitrosyl iron complexes are capable of accelerating skin wound healing, improving the function of penile cavernous tissue, blocking apoptosis development in cell cultures. When decomposed dinitrosyl iron complexes can exert cytotoxic effect that can be used for curing infectious and carcinogenic pathologies.
authors: A F
authors: AF
authors: Vanin
authors: R R
authors: RR
authors: Borodulin
authors: L N
authors: LN
authors: Kubrina
authors: V D
authors: VD
authors: Mikoian
authors: D Sh
authors: DSh
authors: Burbaev
mesh_terms: D003545:Cysteine / Q000737:chemistry; D004548:Elasticity; D004912:Erythrocytes / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry; D006801:Humans; D007501:Iron / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D009589:Nitrogen Oxides / Q000737:chemistry* / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D014664:Vasodilation
chemical_list: D008024:Ligands; D009589:Nitrogen Oxides; D013438:Sulfhydryl Compounds; C073661:dinitrosyl iron complex; D007501:Iron; D005978:Glutathione; D003545:Cysteine