title: Single-nucleotide polymorphisms in genes encoding for CC chemokines were not associated with the risk of non-Hodgkin lymphoma.
abstract: BACKGROUND
  Chemokines play a pivotal role in immune regulation and response, and previous studies suggest an association between immune deficiency and non-Hodgkin lymphoma (NHL).
  
  
  METHODS
  We evaluated the association between NHL and polymorphisms in 18 genes (CCL1, CCL2, CCL5, CCL7, CCL8, CCL11, CCL13, CCL18, CCL20, CCL24, CCL26, CCR1, CCR3, CCR4, CCR6, CCR7, CCR8, and CCR9) encoding for the CC chemokines using data from a population-based case-control study of NHL conducted in Connecticut women.
  
  
  RESULTS
  CCR8 was associated with diffuse large B-cell lymphoma (DLBCL; P = 0.012), and CCL13 was associated with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL; P = 0.003) at gene level. After adjustment for multiple comparisons, none of the genes or single-nucleotide polymorphisms (SNP) were associated with risk of overall NHL or NHL subtypes.
  
  
  CONCLUSIONS
  Our results suggest that the genes encoding for CC chemokines are not significantly associated with the risk of NHL, and further studies are needed to verify these findings.
  
  
  CONCLUSIONS
  Our data indicate that CC chemokine genes were not associated with NHL risk.
authors: Henan Province Cancer Hospital, Office for Cancer Control and Prevention, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.
authors: Qiong
authors: Q
authors: Chen
authors: Tongzhang
authors: T
authors: Zheng
authors: Qing
authors: Q
authors: Lan
authors: Catherine
authors: C
authors: Lerro
authors: Nan
authors: N
authors: Zhao
authors: Qin
authors: Q
authors: Qin
authors: Xiaobin
authors: X
authors: Hu
authors: Huang
authors: H
authors: Huang
authors: Jiaxin
authors: J
authors: Liang
authors: Theodore
authors: T
authors: Holford
authors: Brian
authors: B
authors: Leaderer
authors: Peter
authors: P
authors: Boyle
authors: Stephen J
authors: SJ
authors: Chanock
authors: Nathaniel
authors: N
authors: Rothman
authors: Yawei
authors: Y
authors: Zhang
mesh_terms: D016022:Case-Control Studies; D019742:Chemokines, CC / Q000235:genetics* / Q000276:immunology; D003237:Connecticut / Q000453:epidemiology; D004273:DNA, Neoplasm / Q000097:blood / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D019742:Chemokines, CC; D004273:DNA, Neoplasm
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