title: A device for continuous monitoring of true central fixation based on foveal birefringence.
abstract: A device for continuous monitoring of central fixation utilizes birefringence, the property of the Henle fibers surrounding the human fovea, to change the polarization state of light. A circular scan of retinal birefringence, where the scanning circle encompasses the fovea, allows identification of true central fixation-an assessment much needed in various applications in ophthalmology, psychology, and psychiatry. The device allows continuous monitoring for central fixation over an extended period of time in the presence of fixation targets and distracting stimuli, which may be helpful in detecting attention deficit hyperactivity disorder, autism spectrum disorders, and other disorders characterized by changes in the subject's ability to maintain fixation. A proof-of-concept has been obtained in a small study of ADHD patients and normal control subjects.
authors: Division of Pediatric Ophthalmology and Adult Strabismus, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Wilmer 233, 600 N. Wolfe St, Baltimore, MD 21287, USA. bgramat@jhmi.edu
authors: Boris
authors: B
authors: Gramatikov
authors: Kristina
authors: K
authors: Irsch
authors: Marie
authors: M
authors: Müllenbroich
authors: Nicole
authors: N
authors: Frindt
authors: Yinhong
authors: Y
authors: Qu
authors: Ron
authors: R
authors: Gutmark
authors: Yi-Kai
authors: YK
authors: Wu
authors: David
authors: D
authors: Guyton
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D001718:Birefringence; D002659:Child Development Disorders, Pervasive / Q000503:physiopathology*; D005403:Fixation, Ocular; D005584:Fovea Centralis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods*