title: Platelet monoamine oxidase-A activity and aging: effect of carnosine.
abstract: Platelet mitochondrial MAO-A activity of male albino rats (Wistar strain) was significantly inhibited with an inhibition of its only V max during aging. This age-induced inhibition of platelet MAO-A activity became reversed following the application of higher dosages (2.0-2.5 μg/kg/day, i.t. for 21 consecutive days) of carnosine. Though carnosine at lower dosage (0.5 μg/kg/day, i.t. for 21 consecutive days) was ineffective to platelet mitochondrial MAO-A activity in both young and aged rats, at higher dosages (2.0-2.5 μg/kg/day, i.t. for 21 consecutive days) under similar condition this enzyme activity was significantly enhanced. Carnosine at 1.0 μg/kg/day, i.t. for 21 consecutive days significantly enhanced MAO-A activity only in aged (18 and 24 months) rats. These results suggest that carnosine withdraws the aging-induced inhibition of mammalian blood platelet MAO-A activity and restores its activity towards that (MAO-A activity) observed in young mammalian blood platelets.
authors: Department of Biochemistry, University of Calcutta, 35, B.C. Road, Kolkata 700 019, India.
authors: S
authors: S
authors: Banerjee
authors: M K
authors: MK
authors: Poddar
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D001792:Blood Platelets / Q000201:enzymology*; D002336:Carnosine / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood* / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000008:administration & dosage
chemical_list: D012701:Serotonin; D002336:Carnosine; D008995:Monoamine Oxidase
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