title: On the respiratory mechanics measured by forced oscillation technique in patients with systemic sclerosis.
abstract: BACKGROUND
  Pulmonary complications are the most common cause of death and morbidity in systemic sclerosis (SSc). The forced oscillation technique (FOT) offers a simple and detailed approach to investigate the mechanical properties of the respiratory system. We hypothesized that SSc may introduce changes in the resistive and reactive properties of the respiratory system, and that FOT may help the diagnosis of these abnormalities.
  
  
  RESULTS
  We tested these hypotheses in controls (n = 30) and patients with abnormalities classified using spirometry (n = 52) and pulmonary volumes (n = 29). Resistive data were interpreted with the zero-intercept resistance (Ri) and the slope of the resistance (S) as a function of frequency. Reactance changes were evaluated by the mean reactance between 4 and 32 Hz (Xm) and the dynamic compliance (Crs,dyn). The mechanical load was evaluated using the absolute value of the impedance in 4 Hz (Z4Hz). A compartmental model was used to obtain central (R) and peripheral (Rp) resistances, and alveolar compliance (C). The clinical usefulness was evaluated by investigating the area under the receiver operating characteristic curve (AUC). The presence of expiratory flow limitation (EFL) was also evaluated. For the groups classified using spirometry, SSc resulted in increased values in Ri, R, Rp and Z4Hz (p<0.003) and reductions in Crs,dyn, C and Xm (p<0.004). Z4Hz, C and Crs,dyn exhibited a high diagnostic accuracy (AUC>0.90). In groups classified by pulmonary volume, SSc resulted in reductions in S, Xm, C and Crs,dyn (p<0.01). Xm, C and Crs,dyn exhibited adequate diagnostic accuracy (AUC>0.80). It was also observed that EFL is not common in patients with SSc.
  
  
  CONCLUSIONS
  This study provides evidence that the respiratory resistance and reactance are changed in SSc. This analysis provides a useful description that is of particular significance for understanding respiratory pathophysiology and to ease the diagnosis of respiratory abnormalities in these patients.
authors: Biomedical Instrumentation Laboratory, Institute of Biology and Faculty of Engineering, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors: Ingrid Almeida
authors: IA
authors: Miranda
authors: Alvaro Camilo
authors: AC
authors: Dias Faria
authors: Agnaldo José
authors: AJ
authors: Lopes
authors: José Manoel
authors: JM
authors: Jansen
authors: Pedro
authors: P
authors: Lopes de Melo
mesh_terms: D000328:Adult; D000886:Anthropometry; D019540:Area Under Curve; D017097:Electric Impedance; D005260:Female; D005540:Forced Expiratory Flow Rates / Q000502:physiology; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D012015:Reference Standards; D012129:Respiratory Function Tests / Q000379:methods*; D015656:Respiratory Mechanics / Q000502:physiology*; D012595:Scleroderma, Systemic / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D013147:Spirometry
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