title: Consumption of sugary foods and drinks and risk of endometrial cancer.
abstract: Consumption of foods high in sugar promotes insulin production, which has been linked to endometrial carcinogenesis. We evaluated the impact of dietary intake of sugary foods and beverages, as well as added sugar and total sugar on endometrial cancer risk in a population-based case-control study, including 424 cases and 398 controls. Participants completed an interview and food frequency questionnaire, and provided self-recorded waist and hip measurements. Women in the highest quartile of added sugar intake had significantly increased endometrial cancer risk (OR = 1.84, 95% CI 1.16-2.92). Among women with waist-to-hip ratio ≥0.85, risk was significantly higher for the highest versus lowest tertile of added sugar intakes (OR = 2.50, 95% CI 1.38-4.52). The association with added sugar also became stronger when analyses were restricted to never users of hormone replacement therapy (OR = 2.03; 95% CI 1.27-3.26, for highest versus lowest tertile). There was little evidence of effect modification by body mass index or physical activity. Given the high prevalence of intake of sugary foods and drinks in Western populations, additional research is warranted to confirm our findings on endometrial cancer.
authors: The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.
authors: Melony G
authors: MG
authors: King
authors: Urmila
authors: U
authors: Chandran
authors: Sara H
authors: SH
authors: Olson
authors: Kitaw
authors: K
authors: Demissie
authors: Shou-En
authors: SE
authors: Lu
authors: Niyati
authors: N
authors: Parekh
authors: Elisa V
authors: EV
authors: Bandera
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000009:adverse effects; D019422:Dietary Sucrose / Q000008:administration & dosage / Q000009:adverse effects; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D018570:Risk Assessment; D049629:Waist-Hip Ratio
chemical_list: D004040:Dietary Carbohydrates; D019422:Dietary Sucrose
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