title: [The antiaggregant action of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine in in vitro and ex vivo experiments].
abstract: The influence of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine (H-29) on the platelet aggregation has been studied in experiments on donor plasma in vitro. It is established that H-29 causes a decrease in the platelet interaction induced by ADP and arachidonic acid. The influence of H-29 on platelet aggregation was also studied in ex vivo experiments with intravenous and oral administration, and some parameters of plasmatic hemostasis were evaluated.
authors: Iu S
authors: IuS
authors: Logvinova
authors: V A
authors: VA
authors: Makarov
authors: O N
authors: ON
authors: Chupakhin
authors: L P
authors: LP
authors: Sidorova
authors: N M
authors: NM
authors: Perova
authors: V L
authors: VL
authors: Rusinov
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D009025:Morpholines / Q000138:chemical synthesis / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D010976:Platelet Count; D011817:Rabbits; D013829:Thiadiazines / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: C581723:2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine; D009025:Morpholines; D010975:Platelet Aggregation Inhibitors; D013829:Thiadiazines; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate