title: [Influence of different tranexamic acid administration methods during and after cardiac surgery on coagulation function and postoperative blood loss].
abstract: OBJECTIVE
  To evaluate the influence of different tranexamic acid administration methods during and after cardiac surgery with cardiopulmonary bypass(CPB) on coagulation function and postoperative bleeding.
  
  
  METHODS
  Patients undergoing elective cardiac surgery with use of CPB (n=60) were randomized in a double-blind fashion to one of two treatment groups:group A(n=30) , administered with tranexamic acid 10 mg/kg (intravenous injection slowly before skin incision) , followed by infusion of normal saline until postoperative 12 hours;and group B(n=30) , administered with tranexamic acid 10 mg/kg(intravenous injection slowly before skin incision) , followed by infusion of tranexamic acid 1 mg/(kg·h) until postoperative 12 hours. Hemoglobin, platelet count, and coagulation function were assessed before anesthesia induction, after surgery, 8am next day and 24 hours after surgery. Bleeding, allogeneic blood transfusion, and fluid infusion during the postoperative 24 hours were recorded.
  
  
  RESULTS
  No differences were found between groups in terms of coagulant function, postoperative bleeding, allogeneic blood transfusion, and fluid infusion(P>0.05) .
  
  
  CONCLUSIONS
  Compared with intraoperative administration alone, prolonged treatment with tranexamic acid after cardiac surgery shows no advantage because it can not further improve coagulant function, reduce bleeding, or reduce allogeneic blood transfusion.
authors: Department of Anesthesiology,PUMC Hospital, CAMS and PUMC, Beijing, China.
authors: Jing-jie
authors: JJ
authors: Wang
authors: Guang-jun
authors: GJ
authors: Chen
authors: Wei
authors: W
authors: Liu
authors: Yu-guang
authors: YG
authors: Huang
authors: Ai-lun
authors: AL
authors: Luo
authors: Qi
authors: Q
authors: Miao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000933:Antifibrinolytic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D059035:Perioperative Period; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D011184:Postoperative Period; D014148:Tranexamic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid