title: Effect of dietary polyphenols from hop (Humulus lupulus L.) pomace on adipose tissue mass, fasting blood glucose, hemoglobin A1c, and plasma monocyte chemotactic protein-1 levels in OLETF rats.
abstract: Hop (Humulus lupulus L.) pomace contains procyanidin-rich polyphenols, which are large oligomeric compounds of catechin. We studied the effect of high dose (1%) of dietary hop pomace polyphenols (HPs) in Otsuka Long-EvansTokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. By 70 days, the rats fed HPs tended to have a lower body weight and reduced mesenteric white adipose tissue weight than the rats fed a control diet. Triglyceride levels in both plasma and liver tended to be lower in the HPs-fed group than in the control group. Dietary HPs substantially suppressed the activities of hepatic fatty acid synthetase, glucose-6-phosphate dehydrogenase, and malic enzyme, through the suppression of SREBP1c mRNA expression in OLETF rats. Moreover, in the HPs-fed group, monocyte chemotactic protein-1 (MCP-1) expression and fasting blood glucose levels at 40 days, and hemoglobin A1c (HbA1c) levels at 70 days were significantly lower than those in the control group. Thus, dietary HPs may exert an ameliorative function on hepatic fatty acid metabolism, glucose metabolism, and inflammatory response accompanying the increase of the adipose tissue mass in OLETF rats.
authors: Department of Agricultural Chemistry, School of Agriculture, Meiji University, Kanagawa, Japan.
authors: Kazuki
authors: K
authors: Yui
authors: Hiroki
authors: H
authors: Uematsu
authors: Keisuke
authors: K
authors: Muroi
authors: Kazuhiro
authors: K
authors: Ishii
authors: Minako
authors: M
authors: Baba
authors: Kyoichi
authors: K
authors: Osada
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002392:Catechin / Q000737:chemistry / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005215:Fasting / Q000097:blood*; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis; D027582:Humulus / Q000737:chemistry*; D008291:Malate Dehydrogenase / Q000096:biosynthesis; D008297:Male; D051381:Rats; D051780:Sterol Regulatory Element Binding Protein 1 / Q000096:biosynthesis; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; C497389:Srebf1 protein, rat; D051780:Sterol Regulatory Element Binding Protein 1; D014280:Triglycerides; D002392:Catechin; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase