title: Interrater reliability of the new criteria for behavioral variant frontotemporal dementia.
abstract: OBJECTIVE
  To evaluate the interrater reliability of the new International Behavioural Variant FTD Criteria Consortium (FTDC) criteria for behavioral variant frontotemporal dementia (bvFTD).
  
  
  METHODS
  Twenty standardized clinical case modules were developed for patients with a range of neurodegenerative diagnoses, including bvFTD, primary progressive aphasia (nonfluent, semantic, and logopenic variant), Alzheimer disease, and Lewy body dementia. Eighteen blinded raters reviewed the modules and 1) rated the presence or absence of core diagnostic features for the FTDC criteria, and 2) provided an overall diagnostic rating. Interrater reliability was determined by κ statistics for multiple raters with categorical ratings.
  
  
  RESULTS
  The mean κ value for diagnostic agreement was 0.81 for possible bvFTD and 0.82 for probable bvFTD ("almost perfect agreement"). Interrater reliability for 4 of the 6 core features had "substantial" agreement (behavioral disinhibition, perseverative/compulsive, sympathy/empathy, hyperorality; κ = 0.61-0.80), whereas 2 had "moderate" agreement (apathy/inertia, neuropsychological; κ = 0.41-0.6). Clinician years of experience did not significantly influence rater accuracy.
  
  
  CONCLUSIONS
  The FTDC criteria show promise for improving the diagnostic accuracy and reliability of clinicians and researchers. As disease-altering therapies are developed, accurate differential diagnosis between bvFTD and other neurodegenerative diseases will become increasingly important.
authors: Memory and Aging Center, Department of Neurology, University of California San Francisco, USA. LaMarreA@radonc.ucsf.edu
authors: Amanda K
authors: AK
authors: Lamarre
authors: Katya
authors: K
authors: Rascovsky
authors: Alan
authors: A
authors: Bostrom
authors: Parnian
authors: P
authors: Toofanian
authors: Sarah
authors: S
authors: Wilkins
authors: Sharon J
authors: SJ
authors: Sha
authors: David C
authors: DC
authors: Perry
authors: Zachary A
authors: ZA
authors: Miller
authors: Georges
authors: G
authors: Naasan
authors: Robert
authors: R
authors: Laforce
authors: Jayne
authors: J
authors: Hagen
authors: Leonel T
authors: LT
authors: Takada
authors: Maria Carmela
authors: MC
authors: Tartaglia
authors: Gail
authors: G
authors: Kang
authors: Douglas
authors: D
authors: Galasko
authors: David P
authors: DP
authors: Salmon
authors: Sarah Tomaszewski
authors: ST
authors: Farias
authors: Berneet
authors: B
authors: Kaur
authors: John M
authors: JM
authors: Olichney
authors: Lovingly
authors: L
authors: Quitania Park
authors: Mario F
authors: MF
authors: Mendez
authors: Po-Heng
authors: PH
authors: Tsai
authors: Edmond
authors: E
authors: Teng
authors: Bradford Clark
authors: BC
authors: Dickerson
authors: Kimiko
authors: K
authors: Domoto-Reilly
authors: Scott
authors: S
authors: McGinnis
authors: Bruce L
authors: BL
authors: Miller
authors: Joel H
authors: JH
authors: Kramer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D057180:Frontotemporal Dementia / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards*; D015588:Observer Variation; D010820:Physicians / Q000592:standards*; D011584:Psychology / Q000592:standards*; D016037:Single-Blind Method
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