title: Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women.
abstract: OBJECTIVE
  The neuropeptide-Y (NP-Y) gene is a strong candidate gene in the pathophysiology of obesity-linked behavior, and several single-nucleotide polymorphisms of NP-Y have already been linked to body weight and appetite. However, the results from current studies remain inconclusive. The aim of the present study was to test whether a certain functional genetic variant (SNP rs16147) in the NP-Y promoter gene is associated with serum leptin levels and body fat distribution.
  
  
  METHODS
  We genotyped and measured the serum leptin levels of the NP-Y rs16147 polymorphism in 1,097 Caucasian subjects in the context of a population-based, case-control multicenter study. We measured weight, height and waist circumference, from which we then calculated BMI and waist-to-hip ratio (WHR).
  
  
  RESULTS
  We found the CT-genotype of the SNP rs16147 to be significantly associated with lower WHRs and higher serum leptin levels in women, compared to homozygote gene carriers. No association between rs16147, WHR and serum leptin levels was found in men.
  
  
  CONCLUSIONS
  Our results provide evidence that the functionally relevant SNP in the NP-Y promoter gene affects body fat distribution and serum leptin levels in women, pointing towards possible behavioral effects of NPY in obesity.
authors: Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany. jochen.mutschler@puk.zh.ch
authors: Jochen
authors: J
authors: Mutschler
authors: Elvira
authors: E
authors: Abbruzzese
authors: Klaus
authors: K
authors: Wiedemann
authors: Christoph
authors: C
authors: von der Goltz
authors: Christina
authors: C
authors: Dinter
authors: Arian
authors: A
authors: Mobascher
authors: Holger
authors: H
authors: Thiele
authors: Amalia
authors: A
authors: Diaz-Lacava
authors: Norbert
authors: N
authors: Dahmen
authors: Jürgen
authors: J
authors: Gallinat
authors: Tomislav
authors: T
authors: Majic
authors: Nadine
authors: N
authors: Petrovsky
authors: Norbert
authors: N
authors: Thuerauf
authors: Johannes
authors: J
authors: Kornhuber
authors: Gerhard
authors: G
authors: Gründer
authors: Lena
authors: L
authors: Rademacher
authors: Juergen
authors: J
authors: Brinkmeyer
authors: Thomas
authors: T
authors: Wienker
authors: Michael
authors: M
authors: Wagner
authors: Georg
authors: G
authors: Winterer
authors: Falk
authors: F
authors: Kiefer
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000235:genetics* / Q000502:physiology; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D012737:Sex Factors; D018709:Statistics, Nonparametric; D049629:Waist-Hip Ratio; D044465:White People / Q000235:genetics
chemical_list: D020738:Leptin; D009478:Neuropeptide Y