title: NRAS mutant melanoma--undrugable?
abstract: Mutations in the three rat sarcoma (RAS) family members NRAS (neuroblastoma-RAS), HRAS (Harvey-RAS) and KRAS (Kirsten-RAS) are found in one third of human cancers. Among the first oncogenes discovered in cutaneous melanoma was NRAS, which is mutant in up to 20% of tumors causing aberrant signaling in several downstream cascades. Despite, being a highly relevant therapeutic target, design of small molecules selectively inhibiting mutant NRAS in melanoma, to date, remains an unsolved challenge. The end?
authors: Department for Dermatology, University of California San Francisco, Mt Zion Cancer Research Center, California, USA. poschc@derm
authors: Christian
authors: C
authors: Posch
authors: Susana
authors: S
authors: Ortiz-Urda
mesh_terms: D000818:Animals; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D009154:Mutation; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D016283:Proto-Oncogene Proteins p21(ras)