title: The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo.
abstract: Reciprocal inductive interactions between the embryonic and extraembryonic tissues establish the anterior-posterior (AP) axis of the early mouse embryo. The anterior visceral endoderm (AVE) signaling center emerges at the distal tip of the embryo at embryonic day 5.5 and translocates to the prospective anterior side of the embryo. The process of AVE induction and migration are poorly understood. Here we demonstrate that the T-box gene Eomesodermin (Eomes) plays an essential role in AVE recruitment, in part by directly activating the homeobox transcription factor Lhx1. Thus, Eomes function in the visceral endoderm (VE) initiates an instructive transcriptional program controlling AP identity.
authors: Developmental Biology Program, Sloan-Kettering Institute, New York, New York 10065, USA.
authors: Sonja
authors: S
authors: Nowotschin
authors: Ita
authors: I
authors: Costello
authors: Anna
authors: A
authors: Piliszek
authors: Gloria S
authors: GS
authors: Kwon
authors: Chai-an
authors: CA
authors: Mao
authors: William H
authors: WH
authors: Klein
authors: Elizabeth J
authors: EJ
authors: Robertson
authors: Anna-Katerina
authors: AK
authors: Hadjantonakis
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics; D002460:Cell Line; D004622:Embryo, Mammalian; D004707:Endoderm / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D060850:LIM-Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009154:Mutation; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: C491198:Eomes protein, mouse; D060850:LIM-Homeodomain Proteins; C499523:Lhx1 protein, mouse; D020825:T-Box Domain Proteins; D014157:Transcription Factors
keywords: AVE; DVE Lhx1; Eomesodermin; Tbr2; axis formation; visceral endoderm
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