title: FOXO flips the longevity SWItch.
abstract: FOXO transcription factors promote longevity from worms to mammals, but the mechanisms by which FOXO extends lifespan have remained elusive. In the nematode Caenorhabditis elegans, FOXO is now shown to recruit the nucleosome remodelling complex SWI/SNF to its target genes, which is essential for FOXO to elicit stress resistance and longevity.
authors: Department of Genetics, Stanford University, Stanford, California 94305, USA.
authors: Ashley E
authors: AE
authors: Webb
authors: Anne
authors: A
authors: Brunet
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D051858:Forkhead Transcription Factors; D008136:Longevity; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; D014157:Transcription Factors; C108831:daf-16 protein, C elegans
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