title: In vivo and in vitro antıneoplastic actions of caffeic acid phenethyl ester (CAPE): therapeutic perspectives.
abstract: Cancer prevention and treatment strategies have attracted increasing interest. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, specifically inhibits NF-κB at μM concentrations and shows ability to stop 5-lipoxygenase-catalyzed oxygenation of linoleic acid and arachidonic acid. Previous studies have demonstrated that CAPE exhibits antioxidant, antiinflammatory, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and, most improtantly, antineoplastic properties. The primary goal of the present review is to summarize and critically evaluate the current knowledge regarding the anticancer effect of CAPE in different cancer types.
authors: Turgut Ozal University Vocational School of Medical Sciences, Division of Medical Laboratory Techniques, Ankara, Turkey. sumeyyaak@hotmail.com
authors: Sumeyya
authors: S
authors: Akyol
authors: Gulfer
authors: G
authors: Ozturk
authors: Zeynep
authors: Z
authors: Ginis
authors: Ferah
authors: F
authors: Armutcu
authors: M Ramazan
authors: MR
authors: Yigitoglu
authors: Omer
authors: O
authors: Akyol
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy; D002109:Caffeic Acids / Q000494:pharmacology*; D045744:Cell Line, Tumor; D016543:Central Nervous System Neoplasms / Q000188:drug therapy; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D011429:Propolis / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D002109:Caffeic Acids; D011429:Propolis; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol