title: [Prognosis of hepatocellular carcinoma: a study of 832 cases].
abstract: OBJECTIVE
  To investigate the prognostic factors of hepatocellular carcinoma.
  
  
  METHODS
  The purpose of this study was to retrospectively analyze the surgical outcomes of hepatocellular carcinoma (HCC) in 832 patients who underwent hepatic resection between February 2002 and June 2010 in the Cancer Hospital of Chinese Academy of Medical Sciences. Post-resection prognostic factors were assessed using a univariate Kaplan-Meier analysis and a multivariate Cox proportional hazards model.
  
  
  RESULTS
  The overall 1-, 3- and 5-year survival rates were 92.0%, 70.2% and 53.6%, respectively. The disease free survival rates (DFS) were 90.2%, 61.5% and 40.5%, respectively. The univariate analysis showed that a better prognosis for overall survival (OS) was associated with asymptomatic presentation, small tumor, single lesion, high-grade histological differentiation, no vascular tumor embolus, negative serum alpha-fetoprotein (AFP), negative serum alkaline phosphatase (ALP), Child-Pugh class A, no ascites, no/mild cirrhosis, new surgical techniques, no blood transfusion, no regional lymph node metastasis, no major vascular invasion, and no extra-hepatic invasion. The multivariate analysis showed that asymptomatic presentation, small tumor, single lesion, no tumor embolus, negative serum alpha-fetoprotein (AFP), no regional lymph node metastasis, no major vascular invasion, no extra-hepatic invasion, no/mild cirrhosis, and surgical techniques are independent factors for a longer overall survival.
  
  
  CONCLUSIONS
  The prognosis of HCC after resection is influenced by a number of factors. Therefore, regularly screening and early diagnosis, applying surgical techniques to minimize the liver injury, and preventing the aggravation of cirrhosis are important measures to improve the overall survival of HCC patients. For those patients with high risk factors of recurrence, routine follow-up is one of the best methods to be recommended.
authors: Department of Abdominal Surgery, Chinese Academy of Medical Sciences, Beijing, China.
authors: Tao
authors: T
authors: Yan
authors: Jian-jun
authors: JJ
authors: Zhao
authors: Xin-yu
authors: XY
authors: Bi
authors: Hong
authors: H
authors: Zhao
authors: Zhen
authors: Z
authors: Huang
authors: Zhi-yu
authors: ZY
authors: Li
authors: Jian-guo
authors: JG
authors: Zhou
authors: Yuan
authors: Y
authors: Li
authors: Cong
authors: C
authors: Li
authors: Jian-qiang
authors: JQ
authors: Cai
authors: Ping
authors: P
authors: Zhao
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D016063:Blood Loss, Surgical; D001859:Bone Neoplasms / Q000556:secondary; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000473:pathology / Q000601:surgery*; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate; D047368:Tumor Burden; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000509:alpha-Fetoproteins; D000469:Alkaline Phosphatase