title: Analysis of the BOLD Characteristics in Pass-Band bSSFP fMRI.
abstract: Balanced steady-state free precession (bSSFP) has been proposed as an alternative method to acquire the blood oxygenation level dependent contrast. Particularly, pass-band bSSFP functional magnetic resonance imaging (fMRI) is believed to utilize theT2sensitivity of bSSFP in a relatively wide and flat off-resonance frequency band of the bSSFP profile. The method has a potential to provide higher signal to noise ratio (SNR) efficiency with reduced imaging artifacts compared to conventional approaches. Previous experimental results suggested that the level of the functional contrast and its characteristics are significantly influenced by the sequence parameters. However, few of these contrast characteristics have been investigated systematically. In this study, a computer simulation was performed to investigate the sources of functional contrast and the influence of scan parameters on the functional contrast to elucidate the contrast characteristics of pass-band bSSFP fMRI. Experiments were performed to validate the simulation results.
authors: Electrical Engineering, Stanford University, Stanford, CA.
authors: Taek Soo
authors: TS
authors: Kim
authors: Jongho
authors: J
authors: Lee
authors: Jin Hyung
authors: JH
authors: Lee
authors: Gary H
authors: GH
authors: Glover
authors: John M
authors: JM
authors: Pauly
keywords: BOLD contrast; Monte-Carlo simulation; pass-band bSSFP fMRI
references: Magn Reson Med. 2007 May;57(5):905-17
references: 17457883
references: Magn Reson Med. 2008 May;59(5):1099-110
references: 18421687
references: NMR Biomed. 2001 Nov-Dec;14(7-8):490-6
references: 11746942
references: Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5675-9
references: 1608978
references: Magn Reson Med. 2003 Jun;49(6):1019-27
references: 12768579
references: Magn Reson Med. 2003 Feb;49(2):395-7
references: 12541263
references: Neuroimage. 2007 Oct 1;37(4):1227-36
references: 17706432
references: Magn Reson Med. 2006 May;55(5):1197-201
references: 16598728
references: Radiology. 1997 Jul;204(1):272-7
references: 9205259
references: Magn Reson Med. 1995 May;33(5):624-35
references: 7596266
references: NMR Biomed. 2007 Feb;20(1):1-10
references: 16947639
references: Magn Reson Med. 2008 Sep;60(3):661-73
references: 18727099
references: Magn Reson Med. 2007 Feb;57(2):369-79
references: 17260379
references: Neuroimage. 2011 Sep 1;58(1):168-76
references: 21704713
references: Magn Reson Med. 2007 Jan;57(1):67-73
references: 17191247
references: Magn Reson Med. 2009 Jun;61(6):1500-6
references: 19319895
references: Magn Reson Med. 2006 Jan;55(1):161-70
references: 16345040
references: Neuroimage. 2012 Aug 15;62(2):713-9
references: 22036996
references: Magn Reson Med. 2003 Oct;50(4):675-83
references: 14523951
references: Magn Reson Med. 1995 Jul;34(1):4-10
references: 7674897
references: Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5951-5
references: 1631079
references: NMR Biomed. 1994 Mar;7(1-2):12-20
references: 8068520
references: Magn Reson Med. 2006 Jun;55(6):1372-80
references: 16680697
references: Magn Reson Med. 2001 Apr;45(4):533-42
references: 11283978
references: Magn Reson Med. 2003 Jan;49(1):47-60
references: 12509819
references: Nature. 2010 Jun 10;465(7299):788-92
references: 20473285
references: Magn Reson Med. 2005 Mar;53(3):574-83
references: 15723410
references: Magn Reson Med. 2004 Sep;52(3):612-8
references: 15334582
references: Neuroimage. 2004;23 Suppl 1:S208-19
references: 15501092
references: Magn Reson Med. 2001 Jul;46(1):149-58
references: 11443721
references: Proc Natl Acad Sci U S A. 1990 Dec;87(24):9868-72
references: 2124706