title: Acute Renal Failure due to Thrombotic Microangiopathy in Patient with Scleroderma: Autopsy Case Report.
abstract: This study presents a patient who died of acute renal failure (ARF) as a complication of scleroderma. The patient remained normotensive throughout the clinical course. Myeloperoxidase-anti-neutrophil cytoplasmic antibody was negative. Autopsy revealed fibrin thrombi in the glomerular capillaries and afferent arterioles, mesangiolysis, and double contour of the glomerular basement membrane. Contrarily, "onionskin lesions" of renal interlobular arteries, the histological hallmark of scleroderma renal crisis, were not discovered. These findings suggested that thrombotic microangiopathy (TMA) was the cause of ARF. Although the frequency is not high, close monitoring should be given to TMA in scleroderma because of possible mortality.
authors: Faculty of Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
authors: Akihiro
authors: A
authors: Ishizu
authors: Shinji
authors: S
authors: Fukaya
authors: Utano
authors: U
authors: Tomaru
authors: Kazuaki
authors: K
authors: Katsumata
authors: Akira
authors: A
authors: Suzuki
authors: Yuka
authors: Y
authors: Umemoto
authors: Akira
authors: A
authors: Furusaki
authors: Yoshiharu
authors: Y
authors: Amasaki
keywords: acute renal failure; cleroderma; thrombotic microangiopathy
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