title: Jacaric acid is rapidly metabolized to conjugated linoleic acid in rats.
abstract: We have shown previously that jacaric acid (JA; 8c,10t,12c-18:3), which has a conjugated triene system, has a strong anti-tumor effect. However, the characteristics of absorption and metabolism of JA have yet to be determined in vivo, and the details of absorption and metabolism of JA in the small intestine are particularly unclear. This information is required for effective use of JA in humans. Therefore, in this study we examined absorption and metabolism of JA using cannulation of the thoracic duct in rats. Emulsions of two test oils, jacaranda seed oil and tung oil, which contain JA and α-eleostearic acid (α-ESA; 9c,11t,13t-18:3), respectively, were administered to rats and lymph from the thoracic duct was collected over 24 h. We examined the rate of absorption of JA and possible conversion to a conjugated linoleic acid (CLA)containing a conjugated diene system. The positional isomerism of the CLA produced by JA metabolism was determined using gas chromatography-electron impact/mass spectrometry. The rate of absorption and percentage conversion of JA were compared with those of α-ESA. We found that JA is rapidly absorbed and converted to a CLA in rats and that the percentage conversion of JA was lower than that of α-ESA. This is the first report on the absorption and metabolism of JA and this information may be important for application of JA as a functional food.
authors: Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, Sendai, Japan.
authors: Ryo
authors: R
authors: Kijima
authors: Taro
authors: T
authors: Honma
authors: Junya
authors: J
authors: Ito
authors: Masao
authors: M
authors: Yamasaki
authors: Aya
authors: A
authors: Ikezaki
authors: Chihiro
authors: C
authors: Motonaga
authors: Kazuo
authors: K
authors: Nishiyama
authors: Tsuyoshi
authors: T
authors: Tsuduki
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000378:metabolism*; D008042:Linolenic Acids / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019440:Anti-Obesity Agents; D044243:Linoleic Acids, Conjugated; D008042:Linolenic Acids; C579118:jacaric acid