title: [Role of GDNF in the behavior and cognitive impairment of mice induced by chronic stress and aging].
abstract: OBJECTIVE
  To investigate the effects of chronic stress on the spatial learning-memory and the role of glial cell line-derived neurotrophic factor (GDNF) of prefrontal cortex (PFC) and hippocampus (HP) in different age mice.
  
  
  METHODS
  The chronic stress model mice in 21 days with multiple chronic unpredictable stressors were applied. The spontaneous behavior and spatial learning-memory ability of mice were tested, using Open field and Morris water maze task, and the expression of GDNF in HP and PFC were detected by immunohistochemical method.
  
  
  RESULTS
  Compared with young mice, the spontaneous behaviors were significantly decreased and the spatial learning-memory function were significantly decreased (P < 0.05, P < 0.01) in aged mice. The GDNF expression in the CA3, DG of HP and PFC were significantly reduced in aged mice (P < 0.05, P < 0.01). After chronic stress, the spontaneous behaviors were remarkably decreased and the ability of spatial learning-memory of the stress group mice were significantly decreased (P < 0.05, P < 0.01) compared with those of the control group mice. The expression of GDNF in HP and PFC were remarkably reduced (P < 0.05, P < 0.01) in stress group mice. The aged stress mice had more serious changes after chronic stress.
  
  
  CONCLUSIONS
  The brain aging and chronic stress in mice causes behavioral changes and the damage of spatial learning-memory function, and which may be nearly related to the expression of GDNF in HP and PFC.
authors: College of Life Sciences, Qufu Normal University, Qufu 273165, China. sdqfly@mail.qfnu.edu.cn
authors: Ya
authors: Y
authors: Li
authors: Ya-Nan
authors: YN
authors: Zhang
authors: Ya-Jing
authors: YJ
authors: Chen
authors: Guan-Xiong
authors: GX
authors: Zhang
authors: Jian-Xun
authors: JX
authors: Shi
mesh_terms: D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D003072:Cognition Disorders / Q000378:metabolism*; D005260:Female; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D018782:Maze Learning; D051379:Mice; D008815:Mice, Inbred Strains; D013312:Stress, Physiological
chemical_list: D051100:Glial Cell Line-Derived Neurotrophic Factor