title: The β-fibrinogen -455G/A gene polymorphism and the risk of ischaemic stroke in a Polish population.
abstract: OBJECTIVE
  Ischaemic stroke is considered to be multifactorial and interactions between environmental and genetic factors play an important role. Although vascular risk factors are well known, the genetic ones are still undiscovered. In the present study, we assessed the significance of the β-fibrinogen -455G/A gene polymorphism and the risk of ischaemic stroke in a Polish population.
  
  
  METHODS
  426 ischaemic stroke patients classified according to stroke aetiologies (small vessel disease, large vessel disease or cardioembolic stroke) and 234 controls were included in the study. The association of the β-fibrinogen genotypes with ischaemic stroke was tested using logistic regression analysis under dominant, recessive or additive models of inheritance.
  
  
  RESULTS
  The allele and genotype distributions of the β-fibrinogen -455G/A gene polymorphism did not differ significantly between patients and controls (patients: G - 75%, GG - 56.6%, GA - 36.8%, AA - 6.6%; controls: G - 73.7%, GG - 57.3%, GA - 32.9%, AA - 9.8%; p > 0.05, χ2). In addition, logistic regression analysis adjusted for the known risk factors, i.e. hypertension, ischaemic heart disease, myocardial infarction, hypercholesterolaemia, diabetes mellitus and smoking, did not show a role of the studied polymorphism in ischaemic stroke.
  
  
  CONCLUSIONS
  The β-fibrinogen -455G/A gene polymorphism is not a risk factor for ischaemic stroke in a Polish population.
authors: Department of Neurology, Jagiellonian University Medical College, ul. Botaniczna 3, 31-503 Krakow, Poland. agolenia@gmail.com
authors: Aleksandra
authors: A
authors: Golenia
authors: Joanna
authors: J
authors: Chrzanowska-Wasko
authors: Jeremiasz
authors: J
authors: Jagiella
authors: Marcin
authors: M
authors: Wnuk
authors: Antoni
authors: A
authors: Ferens
authors: Aleksandra
authors: A
authors: Klimkowicz-Mrowiec
authors: Mateusz
authors: M
authors: Adamski
authors: Irena
authors: I
authors: Ciecko-Michalska
authors: Agnieszka
authors: A
authors: Slowik
mesh_terms: D000368:Aged; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000235:genetics*; D011044:Poland; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D044465:White People
chemical_list: D005340:Fibrinogen