title: Study the effects of zonisamide on fine structure of rabbit basilar artery and hippocampus in rabbit subarachnoid hemorrhage model.
abstract: BACKGROUND
  In this study, we investigated the effect of a novel antiepileptic drug, zonisamide (ZNS), on the basilar artery and hippocampus in a rabbit subarachnoid hemorrhage (SAH) model.
  
  
  METHODS
  Three groups of New Zealand white rabbits were used: a sham (non-SAH) group, an SAH + saline group, and SAH + drug treatment group that received ZNS. In the treatment group, the subjects were given ZNS for 3 days after the SAH. Hippocampal sections were evaluated for neural tissue degeneration. Basilar artery lumen areas and arterial wall thickness were also measured in all groups.
  
  
  RESULTS
  The mean luminal area of the SAH + ZNS was significantly greater than the SAH + saline group. In addition, the arterial wall thickness of SAH + ZNS group was significantly thinner than the SAH + saline group. The neuronal degeneration scores of the hippocampal CA1 regions in the SAH + ZNS group were significantly lower than the SAH + saline treatment animals.
  
  
  CONCLUSIONS
  These results indicate that ZNS has a vasodilatatory effect on the basilar artery and a neuronal protective effect in the CA1 region of the hippocampus in a rabbit SAH model.
authors: Department of Neurosurgery, Ministry of Health, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
authors: Adnan Yalcin
authors: AY
authors: Demirci
authors: Hakan
authors: H
authors: Seckin
authors: Omer
authors: O
authors: Besalti
authors: Ata Turker
authors: AT
authors: Arikok
authors: Tolga
authors: T
authors: Yigitkanli
authors: Murat
authors: M
authors: Caliskan
authors: Kazim
authors: K
authors: Yigitkanli
authors: Murad
authors: M
authors: Bavbek
mesh_terms: D000818:Animals; D001488:Basilar Artery / Q000187:drug effects* / Q000473:pathology; D004195:Disease Models, Animal; D006624:Hippocampus / Q000098:blood supply / Q000187:drug effects*; D007555:Isoxazoles / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy*; D020301:Vasospasm, Intracranial / Q000188:drug therapy*; D000078305:Zonisamide
chemical_list: D007555:Isoxazoles; D000078305:Zonisamide