title: There is no significant association between death receptor 4 (DR4) gene polymorphisms and lung cancer in Turkish population.
abstract: Death receptor 4 (DR4) gene is a candidate tumor suppressor gene that has a role in apoptotic pathway. It was reported in literature that polymorphisms in DR4 gene lead to susceptibility to many cancers. In accordance with this information, we aimed to investigate the association between G422A, C626G, A683C and A1322G polymorphisms in DR4 gene and lung cancer. We selected 60 patients with lung cancer (LC) and 30 healthy, sex and age matched volunteers randomly. Four polymorhisms, G422A, C626G, A683C and A1322G, in DR4 gene were analyzed with Polymerase Change Reaction (PCR)--Restriction Fragment Lenght Polymorphism (RFLP) and Amplification Refractory Mutation System (ARMS) techniques in both groups. Our results showed that there are no statistically significances between the patients and controls in terms of the G422A, C626G, A683C and A1322G polymorphisms in DR4 gene (p > 0,05). Our findings showed no role of DR4 gene polymorphisms in susceptibility to LC and provide a plausible explanation for DR4 genetic heterogeneity in LC susceptibility.
authors: Vocational School of Health Services, Adıyaman University, TR-02040, Adıyaman, Turkey, deniz-tbio@hotmail.com.
authors: Deniz
authors: D
authors: Taştemir-Korkmaz
authors: Osman
authors: O
authors: Demirhan
authors: Sedat
authors: S
authors: Kuleci
authors: Serap
authors: S
authors: Hastürk
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics*; D014421:Turkey
chemical_list: D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; C105190:TNFRSF10A protein, human
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