title: Reticulated acanthoma with sebaceous differentiation: another sebaceous neoplasm associated with Muir-Torre syndrome?
abstract: Reticulated acanthoma with sebaceous differentiation (RASD) represents a rare benign cutaneous epithelial neoplasm with sebaceous differentiation. There has been much speculation about the relationship between RASD and Muir-Torre syndrome (MTS). We report a 53 year-old man who presented with RASD in addition to a prior history of sebaceous adenomas. Immunohistochemically, the tumour cells in the RASD and sebaceous adenomas showed a significantly reduced MSH6 protein expression, whereas there was no loss of MLH1, MSH2 and PMS2. This benign neoplasm, which can be mistaken for various other cutaneous lesions with sebaceous differentiation, deserves wider recognition for its possible association with MTS.
authors: Division of Dermatopathology and Cutaneous Immunopathology, Mayo Clinic, Rochester, Minnesota, USA; Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
authors: Wonwoo
authors: W
authors: Shon
authors: Michael M
authors: MM
authors: Wolz
authors: Catherine C
authors: CC
authors: Newman
authors: Alina G
authors: AG
authors: Bridges
mesh_terms: D049309:Acanthoma / Q000737:chemistry / Q000473:pathology*; D048868:Adaptor Proteins, Signal Transducing / Q000032:analysis; D000236:Adenoma / Q000737:chemistry / Q000473:pathology*; D000251:Adenosine Triphosphatases / Q000032:analysis; D002454:Cell Differentiation; D045643:DNA Repair Enzymes / Q000032:analysis; D004268:DNA-Binding Proteins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D000070976:Mismatch Repair Endonuclease PMS2; D055653:Muir-Torre Syndrome / Q000378:metabolism / Q000473:pathology*; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein / Q000032:analysis; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000473:pathology*; D009687:Nuclear Proteins / Q000032:analysis; D012627:Sebaceous Glands / Q000473:pathology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein; C501486:MLH1 protein, human; D009687:Nuclear Proteins; D000251:Adenosine Triphosphatases; C094934:PMS2 protein, human; C497172:MSH2 protein, human; D000070976:Mismatch Repair Endonuclease PMS2; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein; D045643:DNA Repair Enzymes
keywords: Muir-Torre syndrome; reticulated acanthoma with sebaceous differentiation; sebaceous neoplasm