title: [Risk factors of predicting residual disease in women with stage I a1 squamous cervical carcinoma after conization].
abstract: OBJECTIVE
  To evaluate the prevalence and influencing factors of residual disease in women with stage I a1 squamous cervical carcinoma after conization.
  
  
  METHODS
  The medical records and histopathologic slides of 83 women diagnosed with stage I a1 squamous cervical carcinoma after cervical conization undergoing subsequent hysterectomy at our hospital between January 2003 and December 2007 were reviewed. The correlations between the presence of residual lesions and clinicopathological features were analyzed.
  
  
  RESULTS
  Among them, 31 (37.3%) had residual disease in hysterectomy specimens, including CIN1 (n = 5), CIN2-3 (n = 10), microinvasive carcinoma (n = 11) and invasive carcinoma (n = 5). In univariate analysis, menopause, procedure of conization, and status of cone margins were associated with the prevalence of residual disease in stage I a1 cervical carcinoma after conization. However, Logistic regression analysis revealed status of cone margins as an independent risk factor for residual disease in stage I a1 cervical carcinoma after conization.
  
  
  CONCLUSIONS
  Status of cone margins is an independent risk factor for residual disease in stage I a1 cervical carcinoma after conization. Further treatment should be performed in patients with positive or nearing cone margins.
authors: Zhejiang, Fuyang Women's Hospital, 311400, China.
authors: Xin-er
authors: XE
authors: Zhu
authors: Yan
authors: Y
authors: Feng
authors: Yun-feng
authors: YF
authors: Fu
authors: Xiao-dong
authors: XD
authors: Cheng
authors: Xiao-duan
authors: XD
authors: Chen
authors: Xing
authors: X
authors: Xie
authors: Wei-guo
authors: WG
authors: Lü
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D015994:Incidence; D008875:Middle Aged; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000453:epidemiology* / Q000473:pathology; D011184:Postoperative Period; D012189:Retrospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology*