title: Reciprocal Homosynaptic and heterosynaptic long-term plasticity of corticogeniculate projection neurons in layer VI of the mouse visual cortex.
abstract: Most neurons in layer VI of the visual cortex project to the dorsal lateral geniculate nucleus (dLGN). These corticogeniculate projection neurons (CG cells) receive top-down synaptic inputs from upper layers (ULs) and bottom-up inputs from the underlying white matter (WM). Use-dependent plasticity of these synapses in layer VI of the cortex has received less attention than in other layers. In the present study, we used a retrograde tracer injected into dLGN to identify CG cells, and, by analyzing EPSPs evoked by electrical stimulation of the UL or WM site, examined whether these synapses show long-term synaptic plasticity. Theta-burst stimulation induced long-term potentiation (LTP) of activated synapses (hom-LTP) and long-term depression (LTD) of nonactivated synapses (het-LTD) in either pathway. The paired-pulse stimulation protocol and the analysis of coefficient variation of EPSPs suggested postsynaptic induction of these changes except UL-induced het-LTD, which may be presynaptic in origin. Intracellular injection of a Ca(2+)-chelator suggested an involvement of postsynaptic Ca(2+) rise in all types of long-term plasticity. Pharmacological analysis indicated that NMDA receptors and type-5 metabotropic glutamate receptors are involved in WM-induced and UL-induced plasticity, respectively. Analysis with inhibitors and/or in transgenic mice suggested an involvement of cannabinoid type 1 receptors and calcineurin in UL-induced and WM-induced het-LTD, respectively. These results suggest that hom-LTP and het-LTD may play a role in switching the top-down or bottom-up regulation of CG cell function and/or in maintaining stability of synaptic transmission efficacy through different molecular mechanisms.
authors: Brain Science Institute RIKEN, Wako, 351-0198 Japan, PRESTO, Japan Science and Technology Agency, Tokyo, 102-0075 Japan.
authors: Masoumeh Kourosh
authors: MK
authors: Arami
authors: Kazuhiro
authors: K
authors: Sohya
authors: Abdolrahman
authors: A
authors: Sarihi
authors: Bin
authors: B
authors: Jiang
authors: Yuchio
authors: Y
authors: Yanagawa
authors: Tadaharu
authors: T
authors: Tsumoto
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002614:Chelating Agents / Q000494:pharmacology; D002772:Cholera Toxin / Q000378:metabolism; D004558:Electric Stimulation; D018683:Excitatory Amino Acid Agents / Q000494:pharmacology; D005260:Female; D005829:Geniculate Bodies / Q000166:cytology* / Q000502:physiology; D005968:Glutamate Decarboxylase / Q000235:genetics; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000235:genetics; D050495:Vesicular Inhibitory Amino Acid Transport Proteins / Q000235:genetics; D014793:Visual Cortex / Q000166:cytology*; D014795:Visual Pathways / Q000502:physiology
chemical_list: D002614:Chelating Agents; D018683:Excitatory Amino Acid Agents; D043884:Receptor, Cannabinoid, CB1; D050495:Vesicular Inhibitory Amino Acid Transport Proteins; C492244:Viaat protein, mouse; D049452:Green Fluorescent Proteins; D002772:Cholera Toxin; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1
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