title: Adenoid cystic carcinoma of the skull base mimicking temporomandibular disorder.
abstract: BACKGROUND
  Temporomandibular disorder (TMD) involves problems of the temporomandibular joint and its adjacent muscular system. Because TMD prevalence is high among Western populations, complaints in these regions are generally attributed to TMD. However, in rare cases, TMD symptoms are mimicked by malignant tumors of the head.
  
  
  METHODS
  Upon first presentation, an 18-year-old female complained about typical symptoms of TMD. After an initial splint therapy and physiotherapy, painful symptoms increased significantly. Twelve weeks after initial diagnosis, further diagnostic imaging revealed a tumor formation at the skull base with infiltration of the infratemporal fossa. Histological evaluation confirmed the diagnosis of adenoid cystic carcinoma. Two years after resection of the tumor, lung metastases were detected with no option of curative treatment.
  
  
  CONCLUSIONS
  TMD symptoms, which are refractory to treatment or exhibit significant worsening during therapy, should be regarded as warning signals and as an indication that early further diagnostic imaging is warranted.
authors: Department of Oral and Maxillofacial Surgery, Plastic Operations, Klinikum Bremen-Mitte, School of Medicine of the University of Göttingen, Bremen, Germany.
authors: Aynur
authors: A
authors: Sari-Rieger
authors: Stefan
authors: S
authors: Hassfeld
authors: Klaus
authors: K
authors: Junker
authors: Jan
authors: J
authors: Rustemeyer
mesh_terms: D000293:Adolescent; D001706:Biopsy; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000628:therapy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary / Q000628:therapy; D008279:Magnetic Resonance Imaging; D038361:Neuronavigation; D010166:Palliative Care; D019292:Skull Base Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013705:Temporomandibular Joint Disorders / Q000175:diagnosis*
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