title: Case experience of 308-nm excimer laser therapy compatibility with PUVA and oral bexarotene for the treatment of cutaneous lesions in mycosis fungoides.
abstract: Little is known about the safety and effectiveness of excimer laser therapy when used in conjunction with other therapies in the treatment of mycosis fungoides (MF) lesions. We describe the use of adjunctive excimer laser therapy in combination with psoralen plus ultraviolet A (PUVA) and oral bexarotene for the treatment of recalcitrant and sanctuary plaques in a patient with MF. In our patient, this regimen successfully induced clinical and histologic resolution in MF plaques with minimal side effects limited to mild, short-lived tenderness and, rarely, local erythema. Our experience suggests that adjunctive excimer laser therapy with PUVA and oral bexarotene has the potential to be a safe, well-tolerated, and effective focal treatment regimen for cutaneous MF lesions.
authors: Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA.
authors: Jing
authors: J
authors: Huang
authors: Shawn
authors: S
authors: Cowper
authors: Jeremy
authors: J
authors: Moss
authors: Michael
authors: M
authors: Girardi
mesh_terms: D000284:Administration, Oral; D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000077610:Bexarotene; D003131:Combined Modality Therapy; D005363:Ficusin / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D054018:Lasers, Excimer / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000473:pathology / Q000628:therapy*; D011701:PUVA Therapy / Q000009:adverse effects / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D013764:Tetrahydronaphthalenes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D016588:Anticarcinogenic Agents; D017319:Photosensitizing Agents; D013764:Tetrahydronaphthalenes; D000077610:Bexarotene; D005363:Ficusin