title: [The initial CT findings in patients suffering from invasive pulmonary aspergillosis].
abstract: OBJECTIVE
  To approach the initial CT findings of invasive pulmonary aspergillosis (IPA) in patients with immunosuppression.
  
  
  METHODS
  All consecutive adult patients who met the diagnostic criteria of the 2008 European Organization for Research and Treatment of Cancer/ Mycoses Study Group (EORTC/MSG) for proven or probable IPA were included as of January 2005 to June 2011. The patients were divided into two groups according to patients with or without hematological malignancy. The initial CT findings in our study were retrospectively reviewed by two thoracic radiologists, while patients' demographics and clinical outcomes were blinded. The pattern and number of abnormalities were recorded.
  
  
  RESULTS
  A total of 65 IPA patients were eligible, with 34 hematological malignancy patients and 31 non-hematological patients. Among all IPA patients, the pattern of ground-glass opacity and consolidation or mass formation was most commonly seen (56.9%), followed by macronodules (46.2%); halo sign (32.3%) was relatively uncommon. Ground-glass opacity and consolidation or mass formation were more commonly identified in non-hematological patients than in hematological malignancy patients (54.8%, 45.2% vs. 8.8%, both P<0.05), but macronodules, infarct-shaped macronodules and halo signs were less frequently identified in the non-hematological group (16.1%, 3.2%, 12.9%, respectively) than in the hematological malignancy group (73.5%, 23.5% and 50.0%, respectively, P<0.05 or P<0.01). The airway-invasive form of IPA was more frequently seen in non-hematological patients (67.8%), whereas the angioinvasive form was more common in hematological malignancy patients (64.7%, P<0.01).
  
  
  CONCLUSIONS
  Our data indicate that CT findings of IPA in non-hematological patients more commonly present as the airway-invasive form, manifesting ground-glass opacity and consolidation or mass formation, whereas in patients with hematological malignancy it more likely shows evidence of the angioinvasive form with macronodules and halo signs.
authors: Department of Respiratory Intensive Care Unit, the First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China. xu_sicheng@yahoo.com.cn
authors: Si-cheng
authors: SC
authors: Xu
authors: Xu-nan
authors: XN
authors: Dong
authors: Tuerdi
authors: T
authors: Baihetinisha
authors: Li-jing
authors: LJ
authors: Deng
authors: Xin-hong
authors: XH
authors: Guo
authors: Xiao-hong
authors: XH
authors: Sang
authors: Li-hua
authors: LH
authors: Qiu
authors: Bing-xiu
authors: BX
authors: Ren
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000000981:diagnostic imaging* / Q000209:etiology; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed