title: Associations between vitamin D and self-reported respiratory disease in older people from a nationally representative population survey.
abstract: OBJECTIVE
  To investigate the association between serum 25-hydroxy vitamin D (25(OH)D) concentrations and respiratory diseases in older people.
  
  
  METHODS
  Cross-sectional, nationally representative sample.
  
  
  METHODS
  Community.
  
  
  METHODS
  Two thousand seventy noninstitutionalized adults aged 65 and older taking part in the Health Survey for England 2005.
  
  
  METHODS
  Serum 25(OH)D levels, self-reported long-term respiratory tract diseases, and covariates (age, sex, social class, season of examination, use of vitamin supplements, and physical health status).
  
  
  RESULTS
  Participants with severe deficiency (25(OH)D < 35 nmol/L) had more than twice the risk of respiratory disease than those in the highest quartile of 25(OH)D status (>64 nmol/L), and those with moderate deficiency (second quartile: 25(OH)D 35-48.9 nmol/L) had 1.75 times greater odds of respiratory diseases, even after adjustment with covariates. Adjusted analysis showed that those in the third quartile (25(OH)D 49.0 to 63.9 nmol/L) also had a greater risk of respiratory disease (odds ratio = 1.63, 95% confidence interval = 1.04-2.57).
  
  
  CONCLUSIONS
  Low serum 25(OH)D concentrations are associated with respiratory disease. Ensuring adequate 25(OH)D levels is of public health importance for older populations living in northern latitudes and may be an effective way to prevent concurrent respiratory infections and related complications in older people. Further studies are required to investigate whether vitamin D supplementation may reduce the incidence and exacerbations of respiratory disease.
authors: Department of Epidemiology and Public Health, University College London Medical School, University College London, London, UK.
authors: Vasant
authors: V
authors: Hirani
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D004739:England / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D015994:Incidence; D008297:Male; D011159:Population Surveillance / Q000379:methods*; D012140:Respiratory Tract Diseases / Q000453:epidemiology* / Q000209:etiology; D057566:Self Report; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000453:epidemiology*
chemical_list: D014807:Vitamin D
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