title: Protein folding in the endoplasmic reticulum.
abstract: In this article, we will cover the folding of proteins in the lumen of the endoplasmic reticulum (ER), including the role of three types of covalent modifications: signal peptide removal, N-linked glycosylation, and disulfide bond formation, as well as the function and importance of resident ER folding factors. These folding factors consist of classical chaperones and their cochaperones, the carbohydrate-binding chaperones, and the folding catalysts of the PDI and proline cis-trans isomerase families. We will conclude with the perspective of the folding protein: a comparison of characteristics and folding and exit rates for proteins that travel through the ER as clients of the ER machinery.
authors: Cellular Protein Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. i.braakman@uu.nl
authors: Ineke
authors: I
authors: Braakman
authors: Daniel N
authors: DN
authors: Hebert
mesh_terms: D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006031:Glycosylation; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism / Q000502:physiology; D017510:Protein Folding; D046188:Protein Modification, Translational; D011499:Protein Processing, Post-Translational
chemical_list: D018832:Molecular Chaperones
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