title: Autophagy in axonal and dendritic degeneration.
abstract: Degeneration of axons and dendrites is a common and early pathological feature of many neurodegenerative disorders, and is thought to be regulated by mechanisms distinct from those determining death of the cell body. The unique structures of axons and dendrites (collectively neurites) may cause them to be particularly vulnerable to the accumulation of protein aggregates and damaged organelles. Autophagy is a catabolic mechanism in which cells clear protein aggregates and damaged organelles. Basal autophagy occurs continuously as a housekeeping function, and can be acutely expanded in response to stress or injury. Emerging evidence shows that insufficient or excessive autophagy contributes to neuritic degeneration. Here, we review the recent progress that has begun to reveal the role of autophagy in neurite function and degeneration.
authors: Department of Pharmacology, Hangzhou Key Laboratory of Medical Neurobiology, School of Medicine, Hangzhou Normal University, Hangzhou 310036, PR China. yyang@hznu.edu.cn
authors: Yi
authors: Y
authors: Yang
authors: Michael
authors: M
authors: Coleman
authors: Lihui
authors: L
authors: Zhang
authors: Xiaoxiang
authors: X
authors: Zheng
authors: Zhenyu
authors: Z
authors: Yue
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D001369:Axons / Q000378:metabolism / Q000473:pathology; D003712:Dendrites / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009410:Nerve Degeneration / Q000378:metabolism / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology
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