title: Omega-3 fatty acids are related to abnormal emotion processing in adolescent boys with attention deficit hyperactivity disorder.
abstract: BACKGROUND
  In addition to the core symptoms, attention deficit hyperactivity disorder (ADHD) is associated with poor emotion regulation. There is some evidence that children and young adults with ADHD have lower omega-3 levels and that supplementation with omega-3 can improve both ADHD and affective symptoms. We therefore investigated differences between ADHD and non-ADHD children in omega-3/6 fatty acid plasma levels and the relationship between those indices and emotion-elicited event-related potentials (ERPs).
  
  
  METHODS
  Children/adolescents with (n=31) and without ADHD (n=32) were compared in their plasma omega-3/6 indices and corresponding ERPs during an emotion processing task.
  
  
  RESULTS
  Children with ADHD had lower mean omega-3/6 and ERP abnormalities in emotion processing, independent of emotional valence relative to control children. ERP abnormalities were significantly associated with lower omega-3 levels in the ADHD group.
  
  
  CONCLUSIONS
  The findings reveal for the first time that lower omega-3 fatty acids are associated with impaired emotion processing in ADHD children.
authors: Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, United Kingdom. rachel.gow@kcl.ac.uk
authors: Rachel V
authors: RV
authors: Gow
authors: Alexander
authors: A
authors: Sumich
authors: Frederic
authors: F
authors: Vallee-Tourangeau
authors: Michael Angus
authors: MA
authors: Crawford
authors: Kebreab
authors: K
authors: Ghebremeskel
authors: Allain A
authors: AA
authors: Bueno
authors: Joseph R
authors: JR
authors: Hibbeln
authors: Eric
authors: E
authors: Taylor
authors: Daniel A
authors: DA
authors: Wilson
authors: Katya
authors: K
authors: Rubia
mesh_terms: D000293:Adolescent; D019540:Area Under Curve; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood* / Q000503:physiopathology / Q000523:psychology; D016022:Case-Control Studies; D002648:Child; D004566:Electrodes; D004644:Emotions; D005149:Facial Expression; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D043371:Fatty Acids, Omega-6 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6
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