title: The effect of aerobic exercise intensity on attenuation of postprandial lipemia is dependent on apolipoprotein E genotype.
abstract: OBJECTIVE
  To investigate the effect of aerobic exercise intensity on postprandial lipemia according to allelic variants of the apolipoprotein E gene.
  
  
  METHODS
  Three groups of 10 healthy men each were formed based genotyping of the APOE gene, rested or performed 500 Kcal tests in a random sequence separated by a minimum 48 h interval, as follows: (a) no exercise (control), (b) intense intermittent exercise, (c) moderate continuous exercise. Each test series was completed 30-min before ingestion of a high-fat meal (1 g fat/kg). Venous blood was collected before and at 1, 2, 3 and 4 h after the high-fat meal. Postprandial lipemia was assessed using the area under the curve approach as well as the kinetic profile of mean lipid variables. Statistical significance was adopted at P ≤ 0.05 level.
  
  
  RESULTS
  The main results show that, in the moderate continuous exercise, total postprandial cholesterolemia was higher in ɛ4 than in ɛ2 carriers, whereas under intense intermittent exercise, total and LDL cholesterolemia were higher in ɛ4 than in ɛ2 and ɛ3 carriers. There was no difference in the lipemic profile of the subjects across APOE genotypes at baseline.
  
  
  CONCLUSIONS
  Moderate and intense exercise were effective in attenuating PPL in both ɛ2 and ɛ3 subjects, with ɛ2 subjects being more susceptible to the lipid lowering effect of moderate training than ɛ3 subjects. Carriers of the ɛ4 allele, however, showed no attenuation of postprandial lipemia.
authors: Núcleo Interdisciplinar de Pesquisa, Faculdades Integradas Promove, Brasília, DF, Brazil. cidopimentel@yahoo.com.br
authors: Aparecido Pimentel
authors: AP
authors: Ferreira
authors: Cristiane Batisti
authors: CB
authors: Ferreira
authors: Ciro José
authors: CJ
authors: Brito
authors: Vinícius Carolino
authors: VC
authors: Souza
authors: Cláudio
authors: C
authors: Córdova
authors: Otávio Toledo
authors: OT
authors: Nóbrega
authors: Nancí Maria
authors: NM
authors: França
mesh_terms: D000328:Adult; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D019540:Area Under Curve; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage / Q000097:blood; D015444:Exercise / Q000502:physiology*; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000235:genetics* / Q000503:physiopathology*; D008297:Male; D005082:Physical Exertion / Q000502:physiology; D019518:Postprandial Period / Q000502:physiology*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001057:Apolipoproteins E; D004041:Dietary Fats; D014280:Triglycerides; D002784:Cholesterol