title: Human dendritic cells subsets as targets and vectors for therapy.
abstract: The skin immune system includes a complex network of dendritic cells (DCs). In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms that maintain immune homeostasis and in pathogenic chronic inflammation in which immune responses are unrestrained. Harnessing DC function by directly targeting DC-derived molecules or by selectively modulating DC subsets is a novel strategy for ameliorating inflammatory diseases. In this short review, we discuss recent advances in understanding the functional specialization of skin DCs and the potential implication for future DC-based therapeutic strategies.
authors: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. eklechevsky@path.wustl.edu
authors: Eynav
authors: E
authors: Klechevsky
authors: Jacques
authors: J
authors: Banchereau
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006706:Homeostasis; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism; D019409:Interleukin-15 / Q000378:metabolism; D007801:Langerhans Cells / Q000166:cytology; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology
chemical_list: D019409:Interleukin-15; D018950:Lipopolysaccharide Receptors; D016753:Interleukin-10