title: Prevalence of HPV-DNA in Pap smears containing ASC and AGC performed within Population Programme of Prophylaxis and Early Detection of Early Cervical Cancer.
abstract: OBJECTIVE
  to assess the incidence of HPV -DNA in women with ASC/AGC compared to patients with normal Pap smears.
  
  
  METHODS
  The study group consisted of 242 women (207 ASC and 35 AGC cases). The control group counted 200 age-matched women with negative Pap smears. Cervical samples collected from all the participants were tested for the presence of HPV-DNA using the Hybrid Capture-2 test.
  
  
  RESULTS
  Total HPV infection was significantly higher in the study than in the control group (43.0% vs.14.0%) (p=0.005). There was no difference in the incidence of HPV -DNA between ASC and AGC groups. Prevalence of HPV-DNA ASC-H was significantly higher in ASC-US group (83.3% vs. 40.5%) (p=0.004). HPV positive endometrial AGC significantly outnumbered HPV positive endocervical AGC (88.9% vs. 26.9%) (p=0.003). Similar trends were observed for the high-risk type of HPV (p<0.001).
  
  
  CONCLUSIONS
  The significant difference in HPV -DNA incidence between the study and control groups suggests that HPV plays a role in the development of ASC and AGC. The implementation of HPV testing in all women diagnosed with ASC or AGC can lead to tailored therapeutic management and more careful follow-up care.
authors: Katedra Połoznictwa i Ginekologii, Klinika Ginekologii i Onkologii, Uniwersytet Jagielloński, Collegium Medicum, Kraków.
authors: Artur
authors: A
authors: Ludwin
authors: Inga
authors: I
authors: Ludwin
authors: Kazimierz
authors: K
authors: Pityński
authors: Robert
authors: R
authors: Jach
authors: Tomasz
authors: T
authors: Banaś
authors: Klaudia
authors: K
authors: Stangel-Wojcikiewicz
authors: Anna
authors: A
authors: Horbaczewska
authors: Miłosz
authors: M
authors: Pietrus
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015897:Comorbidity; D015344:DNA Probes, HPV / Q000032:analysis; D004279:DNA, Viral / Q000302:isolation & purification*; D042241:Early Diagnosis; D004717:Endometrium / Q000473:pathology* / Q000821:virology; D005260:Female; D061809:Human Papillomavirus DNA Tests; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D065006:Papanicolaou Test; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology*; D015995:Prevalence; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000517:prevention & control / Q000821:virology; D014626:Vaginal Smears / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D015344:DNA Probes, HPV; D004279:DNA, Viral