title: Serotonergic genes (5-HTT and HTR1A) and separation life events: gene-by-environment interaction for panic disorder.
abstract: BACKGROUND
  The polymorphisms of serotonergic genes (5-HTTLPR and HTR1A rs6295) and separation life events have been studied to find an association with panic disorder, respectively. However, there are no studies that have yet evaluated the interaction effect between serotonergic genes and separation life events for panic disorder.
  
  
  METHODS
  For this study, 194 panic disorder patients and 172 healthy controls were included for genotyping and environmental factor analysis. Separation life events were assessed using the Stressful Life Events Scale and clinical interviews. To evaluate the potential endophenotypes of panic disorder, the Anxiety Sensitivity Index-revised (ASI-R), harm avoidance in the Temperament and Character Inventory (HA), and neuroticism in the Eysenck Personality Questionnaire (neuroticism) scales were administered.
  
  
  RESULTS
  For 5-HTTLPR and HTR1A rs6295, there was no significant main effect of each genotype on panic disorder alone. However, the number of separation life events and their interaction with 5-HTTLPR showed a statistically significant effect on panic disorder. In addition, the interaction between 5-HTTLPR and the number of separation life events significantly affected the HA for potential endophenotypes.
  
  
  CONCLUSIONS
  This study could suggest the effect of the interaction between 5-HTTLPR and separation life events on panic disorder and its potential endophenotype.
authors: Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
authors: Ah Young
authors: AY
authors: Choe
authors: Borah
authors: B
authors: Kim
authors: Kang Soo
authors: KS
authors: Lee
authors: Ji Eun
authors: JE
authors: Lee
authors: Jun-Yeob
authors: JY
authors: Lee
authors: Tai Kiu
authors: TK
authors: Choi
authors: Sang-Hyuk
authors: SH
authors: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003643:Death; D004243:Divorce; D058068:Endophenotypes; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000235:genetics* / Q000523:psychology*; D010555:Personality Inventory; D011110:Polymorphism, Genetic / Q000235:genetics; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: C583518:HTR1A protein, human; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D044282:Receptor, Serotonin, 5-HT1A