title: [Influence of phthalates from Shaying river on children's intelligence and secretion of thyroid hormone].
abstract: OBJECTIVE
  To investigate the effect of phthalates exposure from drinking water on children's intelligence and secretion of thyroid hormone.
  
  
  METHODS
  Two villages in S County were selected randomly as polluted area and control area according to the distance from the Shaying river basin. Phthalates including DEP, DBP, DMP, DEHP were measured both in the river water and drinking water using HPLC method. Children aged 8 to 13 years old studying in the village primary school were recruited by cluster sampling (n = 154). The combined Reven Test was used to test children intelligence and ELISA method was used to determined thyroid hormone levels.
  
  
  RESULTS
  The concentrations of phthalates (DEP, DBP) were exceeding standards of surface water quality in any of the three sections of the river. Compared to the control area, the concentration of DEP and DBP in drinking water were significant higher in the polluted area than that in control area (P < 0.05). Children from polluted area had significant higher FT4 concentration compared to children from control area (P < 0.05). Intelligence level in children from polluted area was lower than that from control area (P < 0.05).
  
  
  CONCLUSIONS
  The drinking water has been polluted by Shaying river and thyroid hormones levels of children were affected in the polluted areas. It is necessary to verify if this change is related to the phthalates.
authors: Department of Clinical Medicine, Zhengzhou University, Zhengzhou 450001, China. annieli1990@163.com
authors: Anqi
authors: A
authors: Li
authors: Chunyu
authors: C
authors: Tang
authors: Hui
authors: H
authors: Hang
authors: Xuemin
authors: X
authors: Cheng
authors: Yalin
authors: Y
authors: Gao
authors: Hongyang
authors: H
authors: Cheng
authors: Qi
authors: Q
authors: Huang
authors: Yixin
authors: Y
authors: Luo
authors: Yutang
authors: Y
authors: Xue
authors: Qiting
authors: Q
authors: Zuo
authors: Yue
authors: Y
authors: Ba
authors: Liuxin
authors: L
authors: Cui
mesh_terms: D000293:Adolescent; D002648:Child; D003993:Dibutyl Phthalate / Q000009:adverse effects / Q000032:analysis; D060766:Drinking Water / Q000032:analysis; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007360:Intelligence / Q000187:drug effects*; D008297:Male; D010795:Phthalic Acids / Q000009:adverse effects* / Q000032:analysis / Q000737:chemistry; D045483:Rivers; D013963:Thyroid Hormones / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000009:adverse effects* / Q000032:analysis
chemical_list: D060766:Drinking Water; D010795:Phthalic Acids; D013963:Thyroid Hormones; D014874:Water Pollutants, Chemical; D003993:Dibutyl Phthalate