title: Mechanized silica nanoparticles based on pillar[5]arenes for on-command cargo release.
abstract: Mechanized silica nanoparticles, equipped with pillar[5]arene-[2]pseudorotaxane nanovalves, operate in biological media to trap cargos within their nanopores, but release them when the pH is lowered or a competitive binding agent is added. Although cargo size plays an important role in cargo loading, cargo charge-type does not appear to have any significant influence on the amount of cargo loading or its release. These findings open up the possibility of using pillar[n]arene and its derivatives for the formation of robust and dynamic nanosystems that are capable of performing useful functions.
authors: State Key Laboratory of Supramolecular, Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China; Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208-3113, USA.
authors: Yu-Long
authors: YL
authors: Sun
authors: Ying-Wei
authors: YW
authors: Yang
authors: Dai-Xiong
authors: DX
authors: Chen
authors: Guan
authors: G
authors: Wang
authors: Yue
authors: Y
authors: Zhou
authors: Chun-Yu
authors: CY
authors: Wang
authors: J Fraser
authors: JF
authors: Stoddart
keywords: cargo release; drug delivery; pillar[n]enes; silica nanoparticles