title: Association between BDNF-196 G>A and BDNF-270 C>T polymorphisms, BDNF concentration, and rTMS-supported long-term rehabilitation outcome after ischemic stroke.
abstract: BACKGROUND
  The efficacy of rehabilitation in ischemic stroke patients likely varies because of brain plasticity. One of the main neurotrophins in the central nervous system is brain-derived neurotrophic factor (BDNF).
  
  
  OBJECTIVE
  This study aimed to determine allelic and genotypic distribution of BDNF-196 G>A and -270 C>T polymorphisms, and to assess the impact of repetitive transcranial magnetic stimulation (rTMS) on serum BDNF concentrations measured before rehabilitation, after the first 6 h of rehabilitation, and after 3 weeks of rehabilitation.
  
  
  METHODS
  Twenty-six patients with hand paresis and 20 with aphasia were randomly assigned to treatment with rTMS or sham stimulation (placebo group).
  
  
  RESULTS
  In men with aphasia, after the first 6 h of rTMS-supported rehabilitation, BDNF concentration was lower among rTMS-treated patients than placebo-treated patients. A similar difference was observed in women with aphasia after 3 weeks of rTMS-supported rehabilitation. No significant differences in serum BDNF concentration were observed in patients with different BDNF-196 G>A or -270 C>T genotypes. During the observation period, BDNF concentration did not differ significantly between patients who improved and those who did not.
  
  
  CONCLUSIONS
  One possible explanation for the observed difference between rTMS-stimulated and sham-stimulated patients is the suppression of BDNF production by rTMS in the healthy brain hemisphere.
authors: Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland.
authors: Dagmara
authors: D
authors: Mirowska-Guzel
authors: Grazyna
authors: G
authors: Gromadzka
authors: Joanna
authors: J
authors: Seniow
authors: Marcin
authors: M
authors: Lesniak
authors: Marta
authors: M
authors: Bilik
authors: Konrad
authors: K
authors: Waldowski
authors: Katarzyna
authors: K
authors: Gruchala
authors: Andrzej
authors: A
authors: Czlonkowski
authors: Anna
authors: A
authors: Czlonkowska
mesh_terms: D000328:Adult; D000368:Aged; D001037:Aphasia / Q000209:etiology / Q000235:genetics / Q000534:rehabilitation; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood / Q000235:genetics*; D004311:Double-Blind Method; D005260:Female; D007839:Functional Laterality; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010291:Paresis / Q000209:etiology / Q000235:genetics / Q000534:rehabilitation; D011110:Polymorphism, Genetic / Q000235:genetics*; D020521:Stroke / Q000150:complications*; D000071939:Stroke Rehabilitation; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome
chemical_list: D019208:Brain-Derived Neurotrophic Factor