title: Osteonectin expression in surrounding stroma of craniopharyngiomas: association with recurrence rate and brain infiltration.
abstract: Craniopharyngioma is an epithelial tumor of the sellar region with a high survival rate but a high rate of recurrence, especially in children. Hypothalamic involvement, tumor recurrence, and multiple treatments result in clinical deterioration and impaired quality of life. Using immunohistochemistry, we investigated the expression pattern of osteonectin, a marker of tumor invasion and aggressive behavior, in 43 cases of craniopharyngioma. We observed a positive correlation of osteonectin expression in connective-type stromal tissue surrounding the epithelial tumor cells of craniopharyngioma with the extent of central nervous system infiltration and recurrence rate (P < .001). Given the previous success of chemotherapeutic agents that target the tumor microenvironment, our findings on osteonectin expression in stroma of craniopharyngiomas might, hopefully, be a guide to find newer prognostic markers capable of estimating the risk of progression or recurrence. They may also aid in the development of therapeutics that target tumor microenvironment to improve patient outcome.
authors: 1Division of Immunopathology of the Nervous System.
authors: Azadeh
authors: A
authors: Ebrahimi
authors: Juergen
authors: J
authors: Honegger
authors: Hermann
authors: H
authors: Schluesener
authors: Jens
authors: J
authors: Schittenhelm
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D003397:Craniopharyngioma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology; D015676:Osteonectin / Q000032:analysis / Q000096:biosynthesis*; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology; D046888:Tissue Array Analysis; D059016:Tumor Microenvironment; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D015676:Osteonectin
keywords: craniopharyngioma; osteonectin; secreted protein acidic and rich in cysteine (SPARC)