title: Pathogenic and protective role of macrophages in kidney disease.
abstract: Macrophages (MΦ) are located throughout kidney tissue, where they play important roles in homeostasis, surveillance, tolerance, and cytoprotection. MΦ are highly heterogeneous cells and exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease type and stage. Recent studies have identified a dual role for MΦ in several murine models of kidney disease. In this review, we discuss the pathogenic and protective roles of the various MΦ subsets in experimental and human kidney diseases and summarize current progress toward the therapeutic use of MΦ in kidney diseases.
authors: Centre for Transplantation and Renal Research, Westmead Millennium Institute, University of Sydney, Darcy Rd., Westmead, Sydney, NSW, Australia. qi.cao@sydney.edu.au
authors: Qi
authors: Q
authors: Cao
authors: Yiping
authors: Y
authors: Wang
authors: David C H
authors: DC
authors: Harris
mesh_terms: D000818:Animals; D060833:Cellular Microenvironment; D004195:Disease Models, Animal; D006801:Humans; D007668:Kidney / Q000276:immunology / Q000473:pathology*; D007674:Kidney Diseases / Q000276:immunology / Q000473:pathology* / Q000517:prevention & control; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D010641:Phenotype
keywords: cell therapy; kidney disease; macrophages
references: J Clin Invest. 2007 May;117(5):1155-66
references: 17476345
references: Kidney Int. 2004 Dec;66(6):2264-78
references: 15569315
references: Semin Nephrol. 2010 May;30(3):334-44
references: 20620676
references: J Leukoc Biol. 2011 Nov;90(5):845-54
references: 21628332
references: J Immunol. 2001 Apr 1;166(7):4728-36
references: 11254734
references: Int Immunol. 2007 May;19(5):635-43
references: 17446211
references: J Clin Invest. 2012 Dec;122(12):4519-32
references: 23143303
references: Nephrol Dial Transplant. 2001;16 Suppl 5:3-7
references: 11509677
references: J Immunol. 2005 Nov 15;175(10):6257-63
references: 16272275
references: Kidney Int. 2012 May;81(10):969-982
references: 22278021
references: Kidney Int. 2011 Jan;79(2):189-98
references: 20962742
references: Am J Physiol Renal Physiol. 2005 Apr;288(4):F722-31
references: 15561971
references: Arthritis Rheum. 2012 Oct;64(10):3119-28
references: 22614743
references: J Pharmacol Exp Ther. 2008 Jan;324(1):111-7
references: 17932247
references: Kidney Int. 2011 Nov;80(9):915-925
references: 21814171
references: J Am Soc Nephrol. 2006 Feb;17(2):465-74
references: 16396966
references: Kidney Int. 2008 Aug;74(4):405-6
references: 18670402
references: Nephrol Dial Transplant. 2009 Oct;24(10):3012-20
references: 19474282
references: J Immunol. 2008 Dec 1;181(11):8018-26
references: 19017994
references: Lab Invest. 2011 Jul;91(7):978-91
references: 21519331
references: J Clin Invest. 2009 Aug;119(8):2330-42
references: 19587445
references: Lupus. 1998;7(9):597-603
references: 9884096
references: Nat Rev Immunol. 2011 Oct 25;11(11):750-61
references: 22025054
references: J Am Soc Nephrol. 2011 Jan;22(1):21-7
references: 21209251
references: Am J Pathol. 2011 Sep;179(3):1243-56
references: 21762674
references: J Immunol. 2008 Feb 1;180(3):1938-47
references: 18209092
references: J Am Soc Nephrol. 2004 Apr;15(4):940-8
references: 15034096
references: Nat Immunol. 2012 May 20;13(7):642-50
references: 22610140
references: Mediators Inflamm. 2012;2012:146154
references: 22969168
references: Nat Rev Immunol. 2008 Dec;8(12):958-69
references: 19029990
references: Kidney Int. 2007 Sep;72(6):698-708
references: 17597698
references: J Am Soc Nephrol. 2011 Jul;22(7):1229-39
references: 21719780
references: Front Immunol. 2012 Aug 20;3:254
references: 22934094
references: Nat Rev Immunol. 2003 Jan;3(1):23-35
references: 12511873
references: Nephron Exp Nephrol. 2003;94(4):e113-8
references: 12972709
references: J Am Soc Nephrol. 2003 Apr;14(4):888-98
references: 12660323
references: J Immunol. 2002 Jul 15;169(2):1058-67
references: 12097414
references: Nephron Exp Nephrol. 2011;117(3):e47-52
references: 20814218
references: Kidney Int. 2005 Aug;68(2):437-55
references: 16014021
references: Drug Dev Ind Pharm. 1999 May;25(5):591-6
references: 10219527
references: J Pharmacol Sci. 2009 Nov;111(3):285-92
references: 19893275
references: J Am Soc Nephrol. 2004 Jul;15(7):1775-84
references: 15213265
references: Biochem Biophys Res Commun. 2005 Jun 24;332(1):11-6
references: 15896292
references: J Immunol. 2008 May 1;180(9):6270-8
references: 18424750
references: Kidney Int. 2008 Aug;74(4):495-504
references: 18528327
references: Am J Pathol. 2010 Mar;176(3):1256-70
references: 20075196
references: Nephrol Dial Transplant. 2010 Sep;25(9):2908-21
references: 20388633
references: PLoS One. 2012;7(3):e33626
references: 22470459
references: Am J Pathol. 2009 Aug;175(2):580-91
references: 19590041
references: J Am Soc Nephrol. 2005 Dec;16(12):3592-601
references: 16267157
references: Kidney Int. 2003 Jan;63(1):83-95
references: 12472771
references: Transplant Proc. 2004 Nov;36(9):2662-3
references: 15621117
references: Am J Physiol Renal Physiol. 2013 Jan 1;304(1):F68-76
references: 23097468
references: J Immunol. 2011 Apr 15;186(8):4994-5003
references: 21411733
references: Kidney Int. 2001 Jan;59(1):304-16
references: 11135084
references: Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3012-7
references: 20133703
references: Nephrol Dial Transplant. 2005 Dec;20(12):2704-13
references: 16169862
references: Lab Invest. 1984 Aug;51(2):172-80
references: 6611452
references: J Am Soc Nephrol. 2007 Aug;18(8):2350-8
references: 17625118
references: Nat Rev Immunol. 2009 Apr;9(4):259-70
references: 19282852
references: Semin Nephrol. 2010 May;30(3):268-77
references: 20620671
references: J Am Soc Nephrol. 2010 Jun;21(6):933-42
references: 20299353
references: Am J Pathol. 2008 Jun;172(6):1491-9
references: 18467704
references: Nephrology (Carlton). 2005 Oct;10(5):470-7
references: 16221097
references: Front Biosci. 2008 Jan 01;13:453-61
references: 17981560
references: Nat Immunol. 2010 Oct;11(10):936-44
references: 20729857
references: Kidney Int. 1998 Jul;54(1):143-51
references: 9648072
references: Lancet. 1976 Apr 17;1(7964):830-2
references: 56649
references: Transpl Int. 2008 Aug;21(8):728-41
references: 18573142
references: Nephrol Dial Transplant. 2008 Mar;23(3):842-52
references: 17984109
references: Biochem Biophys Res Commun. 2007 Mar 2;354(1):133-9
references: 17210124
references: J Pathol. 2008 Jan;214(1):104-13
references: 17973244
references: Am J Pathol. 2005 Jul;167(1):27-37
references: 15972949
references: J Am Soc Nephrol. 2003 May;14(5):1234-53
references: 12707393
references: Exp Nephrol. 1995 Mar-Apr;3(2):76-9
references: 7773640
references: Kidney Int. 2010 Dec;78(11):1100-9
references: 20463654
references: Kidney Int. 2006 Apr;69(7):1189-97
references: 16609683
references: Kidney Int. 2004 Aug;66(2):542-57
references: 15253705
references: J Clin Invest. 2008 Nov;118(11):3522-30
references: 18982158
references: Immunobiology. 2009;214(3):197-209
references: 19215802
references: Am J Physiol Renal Physiol. 2005 Jul;289(1):F166-74
references: 15701814
references: Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4194-9
references: 20160075
references: Am J Pathol. 2004 Jul;165(1):237-46
references: 15215179
references: J Clin Invest. 2002 Dec;110(12):1859-68
references: 12488436
references: J Clin Invest. 1981 Sep;68(3):686-98
references: 7276168
references: Nephron Exp Nephrol. 2007;105(1):e1-9
references: 17106213
references: J Am Soc Nephrol. 2005 Apr;16(4):977-85
references: 15716328
references: Hum Gene Ther. 1999 Nov 1;10(16):2673-8
references: 10566895
references: J Pathol. 2009 May;218(1):40-7
references: 19156777
references: J Am Soc Nephrol. 2011 Feb;22(2):317-26
references: 21289217
references: J Am Soc Nephrol. 2009 Dec;20(12):2581-92
references: 19926892
references: Lab Invest. 2009 Apr;89(4):470-84
references: 19188913
references: J Am Soc Nephrol. 2005 Dec;16(12):3623-30
references: 16221872
references: Nat Rev Immunol. 2005 Dec;5(12):953-64
references: 16322748
references: Nephrol Dial Transplant. 2006 Aug;21(8):2096-105
references: 16728429
references: J Immunol. 2001 Jan 1;166(1):609-16
references: 11123344
references: Transpl Int. 2008 Aug;21(8):742-54
references: 18573141
references: Nephrol Dial Transplant. 2006 May;21(5):1212-22
references: 16421158
references: Mol Ther. 2002 Dec;6(6):710-7
references: 12498767
references: Kidney Int. 2007 Aug;72(3):290-9
references: 17440493
references: Semin Nephrol. 2010 May;30(3):234-54
references: 20620669
references: Nephron Exp Nephrol. 2011;118(4):e87-99
references: 21311199
references: Kidney Int. 2005 Jun;67(6):2178-86
references: 15882261
references: Nephrol Dial Transplant. 2006 May;21(5):1231-9
references: 16410269