title: Development and characterization of propranolol selective molecular imprinted polymer composite electrospun nanofiber membrane.
abstract: Propranolol (PPL) imprinted microspheres (MIP) were successfully prepared via oil/water polymerization using a methyl methacrylate (MMA) monomer, PLL template, and divinylbenzene (DVB) cross-linker and favorably incorporated in a Eudragit-RS100 nanofiber membrane. A non-PPL imprinted polymer (NIP), without a template, was used as a control. The morphology and particle size of the beads were investigated using scanning electron microscopy. The results revealed that both MIP and NIP had a spherical shape with a micron size of approximately 50-100 μm depending on the amounts of DVB and PPL used. NIP2 (MMA/DVB, 75:2.5) and MIP8 (PPL/MMA/DVB, 0.8:75:2.5) were selected for reloading of PPL, and the result indicated that increasing the ratio of PPL to polymer beads resulted in increase PPL reloading (>80%). A total of 10-50% NIP2 or MIP8 was incorporated into a 40% (w/v) Eudragit-RS100 fiber membrane using an electrospinning technique. PPL could be bound to the 50% MIP8 composite fiber membrane with a higher extent and at a higher rate than the control (NIP2). Furthermore, the MIP8 composite fiber membrane showed higher selectivity to PPL than the other β-blockers (atenolol, metoprolol, and timolol). Thus, the MIP8 composite fiber membrane can be further developed for various applications in pharmaceutical and other affinity separation fields.
authors: Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand.
authors: Prasopchai
authors: P
authors: Tonglairoum
authors: Wanita
authors: W
authors: Chaijaroenluk
authors: Theerasak
authors: T
authors: Rojanarata
authors: Tanasait
authors: T
authors: Ngawhirunpat
authors: Prasert
authors: P
authors: Akkaramongkolporn
authors: Praneet
authors: P
authors: Opanasopit
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003432:Cross-Linking Reagents / Q000737:chemistry; D004337:Drug Carriers; D004655:Emulsions; D008567:Membranes, Artificial; D020366:Methylmethacrylate / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers; D036103:Nanotechnology; D010316:Particle Size; D011433:Propranolol / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D014753:Vinyl Compounds / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D000319:Adrenergic beta-Antagonists; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D004655:Emulsions; D008567:Membranes, Artificial; D014753:Vinyl Compounds; D014867:Water; D020366:Methylmethacrylate; C050528:Eudragit RS; D011433:Propranolol; C004985:divinyl benzene
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