title: Efficient access to 1,4-benzothiazine: palladium-catalyzed double C-S bond formation using Na2S2O3 as sulfurating reagent.
abstract: A novel Pd-catalyzed double C-S bond formation coupling reaction has been developed. This protocol, in which Na2S2O3 was used as sulfurating reagent in metal-catalyzed reactions, provides an efficient method for the synthesis of substituted 1,4-benzothiazine derivates, which are structural elements of numerous bioactivity molecules rendering this protocol attractive to both synthetic and medicinal chemistry.
authors: Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, PR China.
authors: Zongjun
authors: Z
authors: Qiao
authors: Hui
authors: H
authors: Liu
authors: Xiao
authors: X
authors: Xiao
authors: Yana
authors: Y
authors: Fu
authors: Jianpeng
authors: J
authors: Wei
authors: Yuxue
authors: Y
authors: Li
authors: Xuefeng
authors: X
authors: Jiang
mesh_terms: D002384:Catalysis; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013461:Sulfur Oxides / Q000737:chemistry*; D013843:Thiazines / Q000737:chemistry*
chemical_list: C446962:1,4-benzothiazine; D007202:Indicators and Reagents; D013461:Sulfur Oxides; D013843:Thiazines; D010165:Palladium