title: Treatment of tularemia in patient with chronic graft-versus-host disease.
abstract: We describe a case of human tularemia caused by Francisella tularensis subsp. holarctica in a stem cell transplant recipient with chronic graft-versus-host disease who was receiving levofloxacin prophylaxis. The infection was characterized by pneumonia with septic complications. The patient was successfully treated with doxycycline.
authors: Heart and Diabetes Centre North Rhine–Westphalia, Bad Oeynhausen, Germany. jweile@hdz-nrw.de
authors: Jan
authors: J
authors: Weile
authors: Erik
authors: E
authors: Seibold
authors: Cornelius
authors: C
authors: Knabbe
authors: Martin
authors: M
authors: Kaufmann
authors: Wolf
authors: W
authors: Splettstoesser
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004318:Doxycycline / Q000627:therapeutic use*; D005604:Francisella tularensis / Q000302:isolation & purification; D006086:Graft vs Host Disease / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D064704:Levofloxacin; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000627:therapeutic use; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D014406:Tularemia / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin; D004318:Doxycycline
keywords: Francisella tularensis ssp. holarctica; bacteria; chronic graft-versus-host disease; immunocompromised host; tularemia; vector-borne infections
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