title: Obesity and heart failure as a mediator of the cerebrorenal interaction.
abstract: The obesity epidemic is contributing substantially to the burden of cardiovascular disease including heart disease and congestive heart failure, in the United States and the rest of the world. Overnutrition as a driver of obesity, promotes alterations in fatty acid, lipid, and glucose metabolism that influence myocardial function and progression of heart failure from diastolic to systolic failure. The association of progressive heart failure and progressive chronic kidney disease is well documented and often referred to as the cardiorenal syndrome, as well as a prognosticator for cerebrovascular disease (e.g. stroke). Whether the relationship between obesity, heart disease/failure and risk for chronic kidney disease and stroke is direct or a confluence of risk factors is poorly understood.
authors: Department of Internal Medicine, University of Missouri, Columbia, Mo., USA.
authors: Ankur
authors: A
authors: Jindal
authors: Adam
authors: A
authors: Whaley-Connell
authors: James R
authors: JR
authors: Sowers
mesh_terms: D017667:Adipocytes / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001921:Brain / Q000503:physiopathology*; D015984:Causality; D015331:Cohort Studies; D015897:Comorbidity; D004195:Disease Models, Animal; D018450:Disease Progression; D004198:Disease Susceptibility; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006333:Heart Failure / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000503:physiopathology; D007249:Inflammation / Q000453:epidemiology / Q000503:physiopathology; D007333:Insulin Resistance; D007668:Kidney / Q000503:physiopathology*; D008954:Models, Biological; D009206:Myocardium / Q000473:pathology; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology*; D044343:Overnutrition / Q000453:epidemiology; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology / Q000503:physiopathology*; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000503:physiopathology
chemical_list: D005230:Fatty Acids, Nonesterified
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