title: Amyloid-β positron emission tomography imaging probes: a critical review.
abstract: The rapidly rising prevalence and cost of Alzheimer's disease in recent decades has made the imaging of amyloid-β deposits the focus of intense research. Several amyloid imaging probes with purported specificity for amyloid-β plaques are currently at various stages of FDA approval. However, a number of factors appear to preclude these probes from clinical utilization. As the available "amyloid specific" positron emission tomography imaging probes have failed to demonstrate diagnostic value and have shown limited utility for monitoring therapeutic interventions in humans, a debate on their significance has emerged. The aim of this review is to identify and discuss critically the scientific issues contributing to the extensive inconsistencies reported in the literature on their purported in vivo amyloid specificity and potential utilization in patients.
authors: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California-Los Angeles, CA 90095, USA.
authors: Vladimir
authors: V
authors: Kepe
authors: Mateen C
authors: MC
authors: Moghbel
authors: Bengt
authors: B
authors: Långström
authors: Habib
authors: H
authors: Zaidi
authors: Harry V
authors: HV
authors: Vinters
authors: Sung-Cheng
authors: SC
authors: Huang
authors: Nagichettiar
authors: N
authors: Satyamurthy
authors: Doris
authors: D
authors: Doudet
authors: Eyal
authors: E
authors: Mishani
authors: Robert M
authors: RM
authors: Cohen
authors: Poul F
authors: PF
authors: Høilund-Carlsen
authors: Abass
authors: A
authors: Alavi
authors: Jorge R
authors: JR
authors: Barrio
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D016229:Amyloid beta-Peptides; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D011868:Radioisotopes; D012680:Sensitivity and Specificity
chemical_list: D016229:Amyloid beta-Peptides; D011868:Radioisotopes
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