title: A novel CT acquisition and analysis technique for breathing motion modeling.
abstract: To report on a novel technique for providing artifact-free quantitative four-dimensional computed tomography (4DCT) image datasets for breathing motion modeling. Commercial clinical 4DCT methods have difficulty managing irregular breathing. The resulting images contain motion-induced artifacts that can distort structures and inaccurately characterize breathing motion. We have developed a novel scanning and analysis method for motion-correlated CT that utilizes standard repeated fast helical acquisitions, a simultaneous breathing surrogate measurement, deformable image registration, and a published breathing motion model. The motion model differs from the CT-measured motion by an average of 0.65 mm, indicating the precision of the motion model. The integral of the divergence of one of the motion model parameters is predicted to be a constant 1.11 and is found in this case to be 1.09, indicating the accuracy of the motion model. The proposed technique shows promise for providing motion-artifact free images at user-selected breathing phases, accurate Hounsfield units, and noise characteristics similar to non-4D CT techniques, at a patient dose similar to or less than current 4DCT techniques.
authors: UCLA Department of Radiation Oncology, Los Angeles, CA 90095, USA. dlow@mednet.ucla.edu
authors: Daniel A
authors: DA
authors: Low
authors: Benjamin M
authors: BM
authors: White
authors: Percy P
authors: PP
authors: Lee
authors: David H
authors: DH
authors: Thomas
authors: Sergio
authors: S
authors: Gaudio
authors: Shyam S
authors: SS
authors: Jani
authors: Xiao
authors: X
authors: Wu
authors: James M
authors: JM
authors: Lamb
mesh_terms: D016477:Artifacts; D056973:Four-Dimensional Computed Tomography / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D009068:Movement; D012119:Respiration
references: IEEE Trans Med Imaging. 2010 Jan;29(1):196-205
references: 19923044
references: Semin Radiat Oncol. 2004 Jan;14(1):19-26
references: 14752730
references: Phys Med Biol. 2007 Jun 21;52(12):3515-29
references: 17664557
references: J Appl Clin Med Phys. 2009 Oct 07;10(4):132-141
references: 19918227
references: Med Phys. 2010 Mar;37(3):1360-4
references: 20384273
references: IEEE Trans Image Process. 2000;9(12):2083-99
references: 18262946
references: Med Phys. 2003 Jan;30(1):88-97
references: 12557983
references: Int J Radiat Oncol Biol Phys. 2005 Nov 1;63(3):921-9
references: 16140468
references: Med Phys. 2007 Nov;34(11):4098-108
references: 18072476
references: J Appl Clin Med Phys. 2006 Winter;7(1):77-85
references: 16518319
references: Med Phys. 2006 Aug;33(8):2964-74
references: 16964875
references: Med Phys. 2005 Feb;32(2):627-34
references: 15789609