title: Updating clinical endpoint definitions.
abstract: The 6-Minute Walk Distance (6-MWD) has been the most utilized endpoint for judging the efficacy of pulmonary arterial hypertension (PAH) therapy in clinical trials conducted over the past two decades. Despite its simplicity, widespread use in recent trials and overall prognostic value, the 6-MWD has often been criticized over the past several years and pleas from several PAH experts have emerged from the literature to find alternative endpoints that would be more reliable in reflecting the pulmonary vascular resistance as well as cardiac status in PAH and their response to therapy. A meeting of PAH experts and representatives from regulatory agencies and pharmaceutical companies was convened in early 2012 to discuss the validity of current as well as emerging valuable endpoints. The current work represents the proceedings of the conference.
authors: Johns Hopkins University, Baltimore, Maryland, USA.
authors: Paul M
authors: PM
authors: Hassoun
authors: Sylvia
authors: S
authors: Nikkho
authors: Erika B
authors: EB
authors: Rosenzweig
authors: Gail
authors: G
authors: Moreschi
authors: John
authors: J
authors: Lawrence
authors: John
authors: J
authors: Teeter
authors: Christian
authors: C
authors: Meier
authors: Ardeshir H
authors: AH
authors: Ghofrani
authors: Omar
authors: O
authors: Minai
authors: Paula
authors: P
authors: Rinaldi
authors: Evangelos
authors: E
authors: Michelakis
authors: Ronald J
authors: RJ
authors: Oudiz
keywords: clinical trials; end-points; pulmonary arterial hypertension
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