title: The Lynch syndrome: a management dilemma.
abstract: The case of a familial Lynch syndrome is reported. The criteria for early diagnosis, management and surveillance are briefly reviewed. A germline mutation of genes responsible for mismatch repair is at the basis of the Lynch syndrome. Carriers are predisposed to colorectal cancer and other tumors. Two members of the presently reported family developed colorectal cancer, whereas two others developed other neoplasms. The syndrome was confirmed in members of the same family with appropriate genetic workup. Clinical examination and endoscopy were consequently scheduled once-a-year. Given the high risk of neoplastic disease, such yearly controls can be proposed as the standard follow-up of this condition.
authors: "R. Paolucci" Department of Surgery, The University of Rome "La Sapienza", Viale del Policlinico 155, 00161 Rome, Italy. piergaspare.palumbo@uniroma1.it.
authors: Piergaspare
authors: P
authors: Palumbo
authors: Chiara
authors: C
authors: Amatucci
authors: Bruno
authors: B
authors: Perotti
authors: Claudia
authors: C
authors: Dezzi
authors: Marco
authors: M
authors: Girolami
authors: Giulio
authors: G
authors: Illuminati
authors: Alberto M
authors: AM
authors: Angelici
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D019468:Disease Management; D005260:Female; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011379:Prognosis
keywords: Lynch syndrome; NNPCC; clinical management; colorectal cancer