title: Lippia alba (Mill.) N. E. Brown hydroethanolic extract of the leaves is effective in the treatment of migraine in women.
abstract: BACKGROUND
  There is no universally accepted and effective prophylaxis of migraine headache episodes. We aimed to investigate the effects of Lippia alba (Mill.) N. E. Brown (chemotype geranial-carvenone) in the treatment of migraine patients.
  
  
  METHODS
  Twenty-one women were enrolled in a prospective, phase 2, non-controlled cohort study to orally receive hydroethanolic extract of L. alba leaves. Symptom intensity and impact were assessed using MIDAS and HIT-6 instruments before and after 2 months of treatment.
  
  
  RESULTS
  We observed a significant decrease on HIT-6 total score, as well as MIDAS number of missed days, number of headache days, and pain intensity. More than 70% of patients experienced a minimum 50% reduction on pain frequency.
  
  
  CONCLUSIONS
  Treatment with L. alba leaves (geranial-carvenone) hydroethanolic extract is a cheap, safe, widely available, highly effective therapy to reduce both the intensity and the frequency of headache episodes of women with migraine. ClinicalTrials.gov Identifier: NCT01259947.
authors: Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; Spiritist Society "Terra de Ismael," Jardinópolis, Brazil. carmona@fmrp.usp.br
authors: Fabio
authors: F
authors: Carmona
authors: Mateus A
authors: MA
authors: Angelucci
authors: Débora S
authors: DS
authors: Sales
authors: Telma M
authors: TM
authors: Chiaratti
authors: Fernando B
authors: FB
authors: Honorato
authors: Randal V
authors: RV
authors: Bianchi
authors: Ana M S
authors: AM
authors: Pereira
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D032411:Lippia; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011446:Prospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts
keywords: Headache; Lippia alba spec.; Medicinal plant; Migraine; Phytotherapy