title: Bisphenol A significantly modulates long-term depression in the hippocampus as observed by multi-electrode system.
abstract: OBJECTIVE
  Low dose exposure to endocrine disrupters (environmental chemicals) may induce hormone-like effects on wildlife and humans. bisphenol A (BPA) might disturb the neuronal signaling regulated by endogenous estrogens. We investigated the rapid modulation effects of 10nM BPA, a typical endocrine disruptor, on long-term depression (LTD) of adult rat hippocampal slices.
  
  
  METHODS
  LTD was induced by a transient perfusion of 30 µM NMDA for 3 min. And measured with multielectrode probes.
  
  
  RESULTS
  A 30 min perfusion of 10 nM BPA rapidly enhanced LTD in CA1, however, BPA suppressed LTD in dentate gyrus (DG). An ERRγ antagonist, 4-OH-tamoxifen, suppressed LTD in CA1 and DG. Inhibitor of estrogen receptor ICI 182,780 did not disturb BPA effects. On the other hand, tributyltin (TBT), another endocrine disruptor, did not have any effect on LTD in CA1 and DG.
  
  
  CONCLUSIONS
  ERRγ, but not estrogen receptors, is a high affinity BPA receptor in LTD processes, since the effect of BPA on LTD was suppressed by an ERRγ antagonist. A possible mechanisms of BPA-induced enhancement of LTD could be described with ERRγ, MAPK activation and phosphorylation of MMDA receptors.
authors: Department of Biophysics and Life Sciences, University of Tokyo, Tokyo, Japan.
authors: Yoshitaka
authors: Y
authors: Hasegawa
authors: Mari
authors: M
authors: Ogiue-Ikeda
authors: Nobuaki
authors: N
authors: Tanabe
authors: Tetsuya
authors: T
authors: Kimoto
authors: Yasushi
authors: Y
authors: Hojo
authors: Takeshi
authors: T
authors: Yamazaki
authors: Suguru
authors: S
authors: Kawato
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D004566:Electrodes; D052244:Endocrine Disruptors / Q000494:pharmacology*; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D036881:Long-Term Synaptic Depression / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011960:Receptors, Estrogen / Q000187:drug effects*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D011960:Receptors, Estrogen; C006780:bisphenol A; D000098826:Bisphenol A Compounds