title: The diagnostic and prognostic significance of SCUBE1 levels in Crimean-Congo hemorrhagic fever.
abstract: BACKGROUND
  The new biochemical marker, signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1), is secreted and cell surface glycoprotein expressed during early embryogenesis. The protein is found in platelet and endothelial cells. Crimean-Congo hemorrhagic fever (CCHF), which is caused by a tick-borne virus belonging to the Bunyaviridae family, may present with a mild clinical course or may exhibit a severe profile with potentially fatal hemorrhaging. The aim of this study was to determine the diagnostic and prognostic significance of SCUBE1 levels in CCHF.
  
  
  METHODS
  This study was conducted with patients with CCHF. SCUBE1 levels in patients with CCHF were determined using an ELISA.
  
  
  RESULTS
  SCUBE1 titers of CCHF patients were significantly higher compared to those of the control group (p=0.0001). SCUBE1 levels of patients with hemorrhage were significantly higher than those of patients without hemorrhage (p=0.0001). SCUBE1 values of patients who died were significantly higher than those of the survivors (p=0.012).
  
  
  CONCLUSIONS
  SCUBE1 levels are a new biomarker that can be used in the differential diagnosis and monitoring of patients hospitalized with suspected CCHF. These levels are also significant as potential predictors of mortality.
authors: Medical Laboratory Program, Vocational School of Health Sciences, Karadeniz Technical University, Trabzon, Turkey; Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. Electronic address: amentese28@gmail.com.
authors: Ahmet
authors: A
authors: Menteşe
authors: Gürdal
authors: G
authors: Yilmaz
authors: Ayşegül
authors: A
authors: Sümer
authors: Mustafa
authors: M
authors: Arslan
authors: Süleyman Caner
authors: SC
authors: Karahan
authors: Iftihar
authors: I
authors: Köksal
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002135:Calcium-Binding Proteins; D005260:Female; D003225:Hemorrhagic Fever Virus, Crimean-Congo; D006479:Hemorrhagic Fever, Crimean / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D012016:Reference Values; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D002135:Calcium-Binding Proteins; D008565:Membrane Proteins; C469998:SCUBE1 protein, human
keywords: Biomarker; CCHF; Hemorrhagic fever; Prognostic significance; SCUBE1