title: Cellular self-defense: how cell-autonomous immunity protects against pathogens.
abstract: Our prevailing view of vertebrate host defense is strongly shaped by the notion of a specialized set of immune cells as sole guardians of antimicrobial resistance. Yet this view greatly underestimates a capacity for most cell lineages-the majority of which fall outside the traditional province of the immune system-to defend themselves against infection. This ancient and ubiquitous form of host protection is termed cell-autonomous immunity and operates across all three domains of life. Here, we discuss the organizing principles that govern cellular self-defense and how intracellular compartmentalization has shaped its activities to provide effective protection against a wide variety of microbial pathogens.
authors: Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, UK. randow@mrc-lmb.cam.ac.uk
authors: Felix
authors: F
authors: Randow
authors: John D
authors: JD
authors: MacMicking
authors: Leo C
authors: LC
authors: James
mesh_terms: D019070:Cell Lineage; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007239:Infections / Q000276:immunology* / Q000382:microbiology* / Q000821:virology; D012261:Ribonucleoproteins / Q000276:immunology; D014122:Toxoplasma / Q000276:immunology; D000099207:SS-A Antigen
chemical_list: D012261:Ribonucleoproteins; D000099207:SS-A Antigen
references: Elife. 2012 Dec 18;1:e00047
references: 23251783
references: Nat Immunol. 2013 Apr;14(4):327-36
references: 23455675
references: Microbes Infect. 2009 Apr;11(5):537-44
references: 19298864
references: Nat Immunol. 2012 Jun 17;13(8):737-43
references: 22706339
references: Nature. 2011 May 22;474(7351):385-9
references: 21602824
references: Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6200-5
references: 17400754
references: Cell Host Microbe. 2008 Nov 13;4(5):458-69
references: 18996346
references: Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19985-90
references: 21045130
references: Cell Host Microbe. 2012 Oct 18;12(4):432-44
references: 23084913
references: Science. 2011 May 6;332(6030):717-21
references: 21551061
references: Science. 2012 Feb 24;335(6071):936-41
references: 22363001
references: Nat Immunol. 2012 Feb 16;13(3):214-22
references: 22344284
references: Science. 2013 May 10;340(6133):697-701
references: 23661751
references: Cell. 2012 Dec 7;151(6):1168-78
references: 23217704
references: Trends Immunol. 2012 Oct;33(10):475-87
references: 22796170
references: Nature. 2011 Sep 14;477(7366):596-600
references: 21918512
references: Cell Host Microbe. 2010 Mar 18;7(3):221-33
references: 20227665
references: Retrovirology. 2011 Jul 01;8:52
references: 21722380
references: Science. 2011 Oct 14;334(6053):255-8
references: 21998396
references: J Immunol. 2009 Nov 1;183(9):5909-16
references: 19812211
references: Cell Host Microbe. 2009 Aug 20;6(2):137-49
references: 19683680
references: Science. 2013 Feb 22;339(6122):975-8
references: 23348507
references: J Cell Biol. 2011 Dec 12;195(6):943-52
references: 22123831
references: Science. 2009 Sep 11;325(5946):1380-4
references: 19745150
references: Immunity. 2012 Aug 24;37(2):302-13
references: 22795875
references: Nature. 2011 Aug 28;477(7366):592-5
references: 21874021
references: Nature. 2010 Nov 18;468(7322):452-6
references: 21085181
references: Nat Rev Immunol. 2010 Feb;10(2):123-30
references: 20098460
references: Science. 2011 Jul 8;333(6039):228-33
references: 21617041
references: Science. 2010 Jan 8;327(5962):167-70
references: 20056882
references: J Virol. 2011 May;85(10):5183-96
references: 21345949
references: Nature. 2012 Jan 15;482(7385):414-8
references: 22246324
references: Cell Host Microbe. 2012 Dec 13;12(6):778-90
references: 23245322
references: Nat Immunol. 2009 Aug;10(8):907-17
references: 19620982
references: Annu Rev Immunol. 2006;24:353-89
references: 16551253
references: Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4622-7
references: 16537383
references: Mol Cell. 2012 Nov 9;48(3):329-42
references: 23022382
references: Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3481-6
references: 22308473
references: Cell. 2012 Aug 17;150(4):803-15
references: 22901810
references: J Virol. 2012 Oct;86(19):10821-8
references: 22855481
references: Cell. 2006 Feb 24;124(4):783-801
references: 16497588
references: Nature. 2008 Jan 24;451(7177):425-30
references: 18200009
references: Nat Rev Immunol. 2013 Mar;13(3):199-206
references: 23411798
references: Sci Signal. 2013 Feb 05;6(261):ra9
references: 23386746
references: Science. 2002 Apr 12;296(5566):298-300
references: 11951031
references: Science. 2013 Feb 15;339(6121):786-91
references: 23258413
references: Nat Rev Immunol. 2012 Apr 25;12(5):367-82
references: 22531325
references: Science. 2010 Nov 19;330(6007):1061-4
references: 21097929
references: Nature. 2011 Jan 20;469(7330):323-35
references: 21248839
references: Nature. 2006 Nov 16;444(7117):323-9
references: 17108957
references: Immunity. 2010 Mar 26;32(3):329-41
references: 20206555
references: Nat Med. 2013 Apr;19(4):458-64
references: 23455712
references: Nat Immunol. 2009 Nov;10(11):1215-21
references: 19820708
references: Cell Host Microbe. 2010 Nov 18;8(5):433-44
references: 21075354
references: Nature. 2011 Nov 06;480(7377):379-82
references: 22056990
references: Insect Biochem Mol Biol. 2005 Jul;35(7):741-54
references: 15894191
references: Cell Host Microbe. 2010 Feb 18;7(2):115-27
references: 20159618
references: Cell. 2007 Oct 5;131(1):46-57
references: 17923087
references: Cell Host Microbe. 2012 Oct 18;12(4):585-97
references: 23084924
references: Nat Struct Mol Biol. 2012 Mar 11;19(4):411-6
references: 22407016