title: Pharmacoresistant epilepsy: unmet needs in solving the puzzle(s).
abstract: Pharmacoresistant epilepsy is a significant medical problem. The 2nd Halifax International Epilepsy Conference & Retreat identified crucial needs, which if successfully addressed, will aid in paving the way to improved lives for people with pharmacoresistant epilepsy. These are needs: (1) for an evidence-based and dynamic definition of pharmacoresistant epilepsy; (2) for a comprehensive description of the natural history of pharmacoresistant epilepsy; (3) for a comprehensive description of the complications and comorbidities of pharmacoresistant epilepsy; (4) for a rigorous delineation of the epidemiology and socioeconomic impact of pharmacoresistant epilepsy; (5) for clinically meaningful diagnostic and prognostic physiologically based electroencephalography (EEG) biomarkers; (6) for clinically meaningful diagnostic and prognostic anatomically based (MRI Imaging) biomarkers; (7) for biomolecular/biochemical mechanistic understanding of etiopathogenesis for pharmacoresistant epilepsy; (8) for representative animal models of pharmacoresistant epilepsy; (9) for new and effective drugs or other novel treatments for pharmacoresistant epilepsy; and (10) to promote continuing research and research funding targeting pharmacoresistant epilepsy.
authors: Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada. donald.weaver@dal.ca
authors: Donald F
authors: DF
authors: Weaver
authors: Bernd
authors: B
authors: Pohlmann-Eden
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D015897:Comorbidity; D004351:Drug Resistance; D004569:Electroencephalography / Q000706:statistics & numerical data / Q000639:trends; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D019317:Evidence-Based Medicine / Q000379:methods / Q000639:trends; D006301:Health Services Needs and Demand / Q000639:trends*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents