title: A tale of metabolites: the cross-talk between chromatin and energy metabolism.
abstract: Mitochondrial metabolism influences histone and DNA modifications by retrograde signaling and activation of transcriptional programs. Considering the high number of putative sites for acetylation and methylation in chromatin, we propose in this perspective article that epigenetic modifications might impinge on cellular metabolism by affecting the pool of acetyl-CoA and S-adenosylmethionine.
authors: The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
authors: Barbara
authors: B
authors: Martinez-Pastor
authors: Claudia
authors: C
authors: Cosentino
authors: Raul
authors: R
authors: Mostoslavsky
mesh_terms: D000105:Acetyl Coenzyme A / Q000378:metabolism; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism*; D004734:Energy Metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D012436:S-Adenosylmethionine / Q000378:metabolism
chemical_list: D002843:Chromatin; D000105:Acetyl Coenzyme A; D012436:S-Adenosylmethionine
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