title: Enzyme-controlled sensing-actuating nanomachine based on Janus Au-mesoporous silica nanoparticles.
abstract: Novel Janus nanoparticles with Au and mesoporous silica faces on opposite sides were prepared using a Pickering emulsion template with paraffin wax as the oil phase. These anisotropic colloids were employed as integrated sensing-actuating nanomachines for enzyme-controlled stimuli-responsive cargo delivery. As a proof of concept, we demonstrated the successful use of the Janus colloids for controlled delivery of tris(2,2'-bipyridyl) ruthenium(II) chloride from the mesoporous silica face, which was grafted with pH-sensitive gatelike scaffoldings. The release was mediated by the on-demand catalytic decomposition of urea by urease, which was covalently immobilized on the Au face.
authors: Department of Analytical Chemistry, Complutense University of Madrid, 28040, Madrid, Spain. rvillalonga@quim.ucm.es
authors: Reynaldo
authors: R
authors: Villalonga
authors: Paula
authors: P
authors: Díez
authors: Alfredo
authors: A
authors: Sánchez
authors: Elena
authors: E
authors: Aznar
authors: Ramón
authors: R
authors: Martínez-Máñez
authors: José M
authors: JM
authors: Pingarrón
mesh_terms: D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives* / Q000737:chemistry; D016880:Anisotropy; D003102:Colloids / Q000737:chemistry; D056831:Coordination Complexes; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000032:analysis / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D014508:Urea / Q000032:analysis / Q000378:metabolism; D014510:Urease / Q000378:metabolism*; D017975:Ruthenium Compounds
chemical_list: D015082:2,2'-Dipyridyl; D003102:Colloids; D056831:Coordination Complexes; D012822:Silicon Dioxide; D014508:Urea; D014510:Urease; C547232:tris(2,2-bipyridine)-ruthenium(II); D017975:Ruthenium Compounds