title: Effects of high performance inulin supplementation on glycemic control and antioxidant status in women with type 2 diabetes.
abstract: BACKGROUND
  The purpose of this study was to evaluate the effects of high performance inulin supplementation on blood glycemic control and antioxidant status in women with type 2 diabetes.
  
  
  METHODS
  In a randomized, triple-blind controlled trial, 49 females (fiber intake <30 g/day, 25<body mass index <35 kg/m(2)) with type 2 diabetes were recruited from the Iran Diabetes Society and from endocrinology and metabolism clinics associated with the Tabriz University of Medical Science. The participants were divided into one of two groups in which the participants either received 10 g/day of inulin (intervention, n=24) or maltodextrin (control, n=25) for 2 months. Fasting blood samples were obtained and both glycemic control and antioxidant status were determined at baseline and at the end of the study.
  
  
  RESULTS
  At the end of the study period, there were significant decreases in fasting plasma glucose (8.47%), glycosylated hemoglobin (10.43%), and malondialdehyde (37.21%) levels and significant increases in total antioxidant capacity (18.82%) and superoxide dismutase activity (4.36%) in the inulin group when compared to the maltodextrin group (P<0.05). Changes in fasting insulin, homeostasis model assessment of insulin resistance, and catalase activity were not significant in the inulin group when compared with the maltodextrin group. Glutathione peroxidase activity remained unchanged in both groups.
  
  
  CONCLUSIONS
  Inulin supplementation may improve some glycemic and antioxidant indices and decrease malondialdehyde levels in women with type 2 diabetes. Further investigations are needed in order to confirm the positive effects that inulin may have on the glycemic and antioxidant indices of patients with type 2 diabetes.
authors: Department of Biochemistry and Diet Therapy, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Bahram
authors: B
authors: Pourghassem Gargari
authors: Parvin
authors: P
authors: Dehghan
authors: Akbar
authors: A
authors: Aliasgharzadeh
authors: Mohammad
authors: M
authors: Asghari Jafar-Abadi
keywords: Antioxidants; Diabetes mellitus, type 2; Insulin resistance; Inulin; Malondialdehyde
references: PLoS One. 2012;7(3):e32841
references: 22412931
references: Proc Nutr Soc. 2003 Feb;62(1):95-9
references: 12740048
references: Diabetes. 1991 Apr;40(4):405-12
references: 2010041
references: Med Sci Monit. 2006 Jul;12(7):RA130-47
references: 16810145
references: J Nutr Sci Vitaminol (Tokyo). 2008 Oct;54(5):396-401
references: 19001772
references: FEMS Microbiol Ecol. 2009 Aug;69(2):222-30
references: 19496820
references: Br J Nutr. 2007 Feb;97(2):349-56
references: 17298705
references: Clin Chem. 2003 Apr;49(4):690-2
references: 12651835
references: Br J Nutr. 2010 Jul;104(1):40-7
references: 20187988
references: Br J Nutr. 2002 May;87 Suppl 2:S287-91
references: 12088531
references: J Nutr Metab. 2011;2011:983038
references: 21437179
references: Nutr Rev. 2009 Apr;67(4):188-205
references: 19335713
references: PLoS One. 2011;6(10):e26725
references: 22053206
references: Curr Pharm Des. 2010;16(7):825-31
references: 20388093
references: Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2163-9
references: 20478349
references: Diabetes. 2006 May;55(5):1484-90
references: 16644709
references: J Nutr. 2000 Jun;130(6):1572-7
references: 10827212
references: J Diabetes. 2011 Mar;3(1):58-66
references: 21040500
references: Curr Pharm Des. 2009;15(13):1546-58
references: 19442172
references: Am J Clin Nutr. 1999 Jan;69(1):64-9
references: 9925124
references: Acta Diabetol. 2008 Mar;45(1):41-6
references: 17924055
references: J Endocrinol. 2005 Jun;185(3):457-65
references: 15930172
references: Br J Nutr. 1999 Jul;82(1):23-30
references: 10655953
references: Clin Nutr. 2004 Jun;23(3):331-40
references: 15158296
references: Br J Nutr. 2005 Apr;93 Suppl 1:S157-61
references: 15877889
references: Am J Clin Nutr. 2009 Jun;89(6):1751-9
references: 19386741
references: Nutr Metab Cardiovasc Dis. 2005 Aug;15(4):316-28
references: 16054557
references: J Nutr. 2007 Nov;137(11 Suppl):2503S-2506S
references: 17951493
references: Diabetologia. 1985 Jul;28(7):412-9
references: 3899825
references: Methods Enzymol. 1984;105:121-6
references: 6727660
references: Mol Nutr Food Res. 2011 Nov;55(11):1735-9
references: 21936050