title: Single vertebra tuberculosis presenting with solitary localized osteolytic lesion in young adult lumbar spines.
abstract: OBJECTIVE
  To describe the clinical and imaging findings in young adults with single vertebra tuberculosis presenting with solitary osteolytic lesions.
  
  
  METHODS
  Six patients with proven tuberculosis of a single vertebra of the lumbar spine presenting with solitary osteolytic lesion were retrospectively evaluated. There were four male and two female patients with a mean age of 27.6 years (range, 22-38 years). The clinical and imaging features (plain radiographs, CT and MRI) were studied in all six patients.
  
  
  RESULTS
  Involvement occurred from L1 to L5 vertebral levels. The patients presented with local back pain and tenderness but without any obvious deformity of spine or cold abscess. In each case, imaging demonstrated a well-defined, solitary, lytic lesion of average diameter 1.6 cm with thin sclerotic margins within a vertebral body. There were no fragments within the lesions and no paravertebral soft tissue extension around the affected vertebral bodies. The tuberculous eitology was confirmed by CT-guided biopsy in two patients and by curettage of the lesion in four.
  
  
  CONCLUSIONS
  Tuberculosis affecting a single vertebral body presenting with a localized solitary osteolytic lesion is an unusual form of single vertebra tuberculosis. MRI combined with CT scan of the vertebral body can be very helpful for precisely defining the location of the lesion and extent of osseous destruction. Such small, solitary, osteolytic lesions are often confused with other single vertebra diseases that can have similar appearances on imaging.
authors: Department of Orthopaedics, The General Hospital of PLA, Lanzhou, China. zhenpingok@163.com
authors: Ping
authors: P
authors: Zhen
authors: Xu-sheng
authors: XS
authors: Li
authors: Hao
authors: H
authors: Lu
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000209:etiology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014399:Tuberculosis, Spinal / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D055815:Young Adult
references: Am J Roentgenol Radium Ther Nucl Med. 1957 Aug;78(2):195-212
references: 13444513
references: Skeletal Radiol. 1984;12(3):178-86
references: 6494935
references: AJR Am J Roentgenol. 1989 Aug;153(2):399-405
references: 2750627
references: Clin Orthop Relat Res. 2002 May;(398):11-9
references: 11964626
references: Eur Radiol. 2001;11(4):575-9
references: 11354749
references: Yonsei Med J. 2000 Oct;41(5):657-61
references: 11079627
references: Acta Neurochir (Wien). 1987;88(1-2):26-33
references: 3425410
references: Spinal Cord. 1996 Dec;34(12):716-9
references: 8961428
references: Clin Orthop Relat Res. 2002 May;(398):32-9
references: 11964629
references: Clin Orthop Relat Res. 2002 May;(398):67-74
references: 11964633
references: J Bone Joint Surg Br. 1994 Nov;76(6):863-9
references: 7983108
references: J Neuroradiol. 2000 Dec;27(4):247-52
references: 11223616
references: Radiology. 1993 Nov;189(2):489-93
references: 8210378
references: Spine (Phila Pa 1976). 1997 Aug 1;22(15):1741-6
references: 9259785
references: Ann Surg. 1940 Jul;112(1):138-49
references: 17857618
references: J Bone Joint Surg Am. 1996 Feb;78(2):288-98
references: 8609123
references: Clin Radiol. 1993 Mar;47(3):196-9
references: 8472484
references: J Bone Joint Surg Br. 1984 Mar;66(2):239-42
references: 6707060
references: J Clin Neurosci. 2008 Dec;15(12):1398-400
references: 18952436
references: AJR Am J Roentgenol. 1992 Jun;158(6):1333-45
references: 1590137
references: J Neurosurg. 2002 Jul;97(1 Suppl):151
references: 12120643
references: J Med Assoc Thai. 2007 Aug;90(8):1581-9
references: 17926988
references: Clin Radiol. 2003 Jul;58(7):545-50
references: 12834638
references: J Bone Joint Surg Br. 1980 May;62-B(2):162-5
references: 7364827
references: Neuroradiology. 1996 May;38 Suppl 1:S97-104
references: 8811692
references: Radiology. 1969 May;92(6):1192-5
references: 5790626
references: Spine (Phila Pa 1976). 1998 Jan 1;23(1):47-53
references: 9460152
references: Spine (Phila Pa 1976). 1990 Jun;15(6):605-7
references: 2205932
references: AJR Am J Roentgenol. 1992 Jun;158(6):1275-9
references: 1590123