title: Surveillance of antibiotic susceptibility of Enterobacteriaceae isolated from urine samples collected from community patients in a large metropolitan area, 2010-2012.
abstract: Antibiotic susceptibilities of large cohorts of Enterobacteriaceae isolated from urine collected in the community are scarce. We report the susceptibilities of Enterobacteriaceae isolated from urine of non-selected community populations in a metropolitan area (Leeds and Bradford, UK) over 2 years. Isolates (n = 6614) were identified as follows: Escherichia coli (n = 5436), Klebsiella spp. (n = 525), Proteus mirabilis (n = 305), and 15 other species (n = 290); 58 isolates were unidentified. Ampicillin resistance was observed in 53% E. coli and 28% P. mirabilis; ≥34% E. coli and P. mirabilis were non-susceptible to trimethoprim compared to 20% Klebsiella spp.; nitrofurantoin resistance was observed in 3% E. coli and 15% Klebsiella spp. The occurrence of extended-spectrum β-lactamases (ESBL) was low (6%), as was non-susceptibility to carbapenems, cefipime and tigecycline (<2%). Further surveillance is required to monitor this level of resistance and additional clinical studies are needed to understand the impact on the outcome of current empirical prescribing decisions.
authors: Leeds Teaching Hospitals NHS Trust, Department of Microbiology, Old Medical School, Leeds General Infirmary, Leeds, UK.
authors: C S
authors: CS
authors: Horner
authors: Leeds Teaching Hospitals NHS Trust, Department of Microbiology, Old Medical School, Leeds General Infirmary, Leeds, UK.
authors: N
authors: N
authors: Abberley
authors: Leeds Teaching Hospitals NHS Trust, Department of Microbiology, Old Medical School, Leeds General Infirmary, Leeds, UK.
authors: M
authors: M
authors: Denton
authors: Leeds Teaching Hospitals NHS Trust, Department of Microbiology, Old Medical School, Leeds General Infirmary, Leeds, UK.
authors: M H
authors: MH
authors: Wilcox
mesh_terms: D000480:Alkynes / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D014505:Urban Population / Q000706:statistics & numerical data*
chemical_list: D000480:Alkynes; C094348:antibiotic 07F275
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