title: Rapid quantification of dimethyl methylphosphonate from activated carbon particles by static headspace gas chromatography mass spectrometry.
abstract: Activated carbon (AC) particles are utilized as an adsorbent for binding hazardous vapors in protective equipment. The binding affinity and utilization of these AC particles should be known to ensure effective and efficient use. Therefore, a simple and effective method was developed for the quantification of the chemical warfare agent simulant, dimethyl methylphosphonate (DMMP), from AC particles. Static headspace gas chromatography mass-spectrometry with internal standard, DMMP-d6, was used to perform the analysis. The method produced a linear dynamic range of 2.48-620g DMMP/kg carbon and a detection limit of 1.24g DMMP/kg carbon. Furthermore, the method produced a coefficient of variation of less than 16% for all intra- and inter-assay analyses. The method provided a simple and effective procedure for quantifying DMMP from AC particles and was applied to the analysis of a DMMP-exposed AC protective respirator filter.
authors: Department of Chemistry and Biochemistry, South Dakota State University, Brookings, SD 57007, USA.
authors: Brendan L
authors: BL
authors: Mitchell
authors: Brit G
authors: BG
authors: Billingsley
authors: Brian A
authors: BA
authors: Logue
mesh_terms: D002606:Charcoal / Q000737:chemistry*; D004355:Drug Stability; D008401:Gas Chromatography-Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D016018:Least-Squares Analysis; D057230:Limit of Detection; D009943:Organophosphorus Compounds / Q000032:analysis* / Q000737:chemistry; D015203:Reproducibility of Results; D012134:Respiratory Protective Devices
chemical_list: D009943:Organophosphorus Compounds; D002606:Charcoal; C031116:dimethyl methylphosphonate