title: Low intensity ultrasound perturbs cytoskeleton dynamics.
abstract: Therapeutic ultrasound is widely employed in clinical applications but its mechanism of action remains unclear. Here we report prompt fluidization of a cell and dramatic acceleration of its remodeling dynamics when exposed to low intensity ultrasound. These physical changes are caused by very small strains (10-5) at ultrasonic frequencies (106Hz), but are closely analogous to those caused by relatively large strains (10-1) at physiological frequencies (100Hz). Moreover, these changes are reminiscent of rejuvenation and aging phenomena that are well-established in certain soft inert materials. As such, we suggest cytoskeletal fluidization together with resulting acceleration of cytoskeletal remodeling events as a mechanism contributing to the salutary effects of low intensity therapeutic ultrasound.
authors: Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel ; Program in Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, Massachusetts, USA.
authors: Natalya
authors: N
authors: Mizrahi
authors: Enhua H
authors: EH
authors: Zhou
authors: Guillaume
authors: G
authors: Lenormand
authors: Ramaswamy
authors: R
authors: Krishnan
authors: Daphne
authors: D
authors: Weihs
authors: James P
authors: JP
authors: Butler
authors: David A
authors: DA
authors: Weitz
authors: Jeffrey J
authors: JJ
authors: Fredberg
authors: Eitan
authors: E
authors: Kimmel
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