title: Atopic diathesis in patients with Kawasaki disease.
abstract: OBJECTIVE
  To determine the association between Kawasaki disease (KD) and atopic diathesis (atopic dermatitis [AD], allergic rhinitis, and asthma) in children younger than 5 years of age.
  
  
  METHODS
  In this nationwide study, we aimed to analyze the association and temporal relationship between KD and atopic diathesis. Data were obtained from the National Health Insurance Research Database of Taiwan from 1997 to 2010. In total, 200 patients with KD younger than 5 years of age and 800 age- and sex-matched control subjects were enrolled.
  
  
  RESULTS
  In the whole study population, an increased risk of any concomitant atopic diseases was observed in patients with KD (OR 1.61, 95% CI 1.15-2.26). The risk of AD was increased in male patients between 1 and 5 years of age (OR 3.02, 95% CI 1.22-7.50). More than 60% of the patients developed atopic diseases after the diagnosis of KD.
  
  
  CONCLUSIONS
  There appears to be an association between KD and risk of AD. Most of the atopic diseases occurred after the episode of KD.
authors: Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, Republic of China.
authors: Chian-Yaw
authors: CY
authors: Hwang
authors: Yu-Ya
authors: YY
authors: Hwang
authors: Yi-Ju
authors: YJ
authors: Chen
authors: Chih-Chiang
authors: CC
authors: Chen
authors: Ming-Wei
authors: MW
authors: Lin
authors: Tzeng-Ji
authors: TJ
authors: Chen
authors: Ding-Dar
authors: DD
authors: Lee
authors: Yun-Ting
authors: YT
authors: Chang
authors: Wen-Jeng
authors: WJ
authors: Wang
authors: Han-Nan
authors: HN
authors: Liu
mesh_terms: D001249:Asthma / Q000453:epidemiology / Q000209:etiology; D016022:Case-Control Studies; D002675:Child, Preschool; D016208:Databases, Factual; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology / Q000209:etiology*; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D015999:Multivariate Analysis; D015995:Prevalence; D012221:Rhinitis, Allergic, Perennial / Q000453:epidemiology / Q000209:etiology; D006255:Rhinitis, Allergic, Seasonal / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D013624:Taiwan
keywords: AD; AR; Allergic rhinitis; Atopic dermatitis; CAA; Coronary artery aneurysm; ICD-9; International Classification of Diseases, Ninth Revision; KD; Kawasaki disease; LHID2000; Longitudinal Health Insurance Database 2000