title: Surgical findings in the treatment of Dupuytren's disease after initial treatment with clostridial collagenase (Xiaflex).
abstract: We investigated the difficulty of surgical fasciectomy after previous treatment with clostridial collagenase injection. The 35 clinicians who had participated in the initial trials of this injection were contacted via email. Twenty-eight responded, nine of whom reported on 15 patients. Most (seven of nine) felt there was no significant distortion of anatomy and rated the level of technical difficulty as equivalent to a primary Dupuytren's fasciectomy at the observed degree of contracture (nine of 15 cases). One respondent (four of 15 cases) reported significantly more difficulty and grossly distorted anatomy. One surgical complication, a wound dehiscence, was reported.
authors: Kerlan-Jobe Orthopaedic Clinic, Anaheim, CA, USA.
authors: D C
authors: DC
authors: Hay
authors: Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA, USA.
authors: D L
authors: DL
authors: Louie
authors: Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA, USA.
authors: B E
authors: BE
authors: Earp
authors: Indiana Hand to Shoulder Center, Indianapolis, IN, USA.
authors: F T D
authors: FT
authors: Kaplan
authors: Department of Orthopaedics, Warren Alpert Medical School, Providence, RI, USA.
authors: E
authors: E
authors: Akelman
authors: Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA, USA pblazar@partners.org.
authors: P E
authors: PE
authors: Blazar
mesh_terms: D003131:Combined Modality Therapy; D004387:Dupuytren Contracture / Q000601:surgery*; D000071938:Fasciotomy; D006801:Humans; D003012:Microbial Collagenase / Q000627:therapeutic use*; D019637:Orthopedic Procedures; D012086:Reoperation; D016896:Treatment Outcome
chemical_list: D003012:Microbial Collagenase
keywords: Collagenase Clostridium histolyticum; Dupuytren’s contracture; Xiaflex; surgical fasciectomy