title: HIF2 and endocrine neoplasia: an evolving story.
abstract: In this issue of Endocrine-Related Cancer, Toledo et al. report the identification of activating mutations in the HIF2 (EPAS1) transcription factor in a subset of sporadic pheochromocytomas and paragangliomas. These findings add significantly to an evolving and complex story of the role of hypoxic gene response pathways in human endocrine neoplasia.
authors: Department of Medical Genetics, University of Cambridge, Cambridge, UK. erm1000@medschl.cam.ac.uk
authors: Eamonn R
authors: ER
authors: Maher
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000235:genetics*; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D010235:Paraganglioma / Q000235:genetics*; D010673:Pheochromocytoma / Q000235:genetics*; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D000099162:Endothelial PAS Domain-Containing Protein 1