title: Previous history of chronic stress changes the transcriptional response to glucocorticoid challenge in the dentate gyrus region of the male rat hippocampus.
abstract: Chronic stress is a risk factor for several neuropsychiatric diseases, such as depression and psychosis. In response to stress glucocorticoids (GCs) are secreted that bind to mineralocorticoid and glucocorticoid receptors, ligand-activated transcription factors that regulate the transcription of gene networks in the brain necessary for coping with stress, recovery, and adaptation. Chronic stress particularly affects the dentate gyrus (DG) subregion of the hippocampus, causing several functional and morphological changes with consequences for learning and memory, which are likely adaptive but at the same time make DG neurons more vulnerable to subsequent challenges. The aim of this study was to investigate the transcriptional response of DG neurons to a GC challenge in male rats previously exposed to chronic restraint stress (CRS). An intriguing finding of the current study was that having a history of CRS had profound consequences for the subsequent response to acute GC challenge, differentially affecting the expression of several hundreds of genes in the DG compared with challenged nonstressed control animals. This enduring effect of previous stress exposure suggests that epigenetic processes may be involved. In line with this, CRS indeed affected the expression of several genes involved in chromatin structure and epigenetic processes, including Asf1, Ash1l, Hist1h3f, and Tp63. The data presented here indicate that CRS alters the transcriptional response to a subsequent GC injection. We propose that this altered transcriptional potential forms part of the molecular mechanism underlying the enhanced vulnerability for stress-related disorders like depression caused by chronic stress.
authors: Division of Medical Pharmacology, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands. n.datson@prosensa.nl
authors: Nicole A
authors: NA
authors: Datson
authors: Jessica M E
authors: JM
authors: van den Oever
authors: Oksana B
authors: OB
authors: Korobko
authors: Ana Maria
authors: AM
authors: Magarinos
authors: E Ronald
authors: ER
authors: de Kloet
authors: Bruce S
authors: BS
authors: McEwen
mesh_terms: D052636:Allostasis; D000818:Animals; D002908:Chronic Disease; D018891:Dentate Gyrus / Q000378:metabolism / Q000503:physiopathology*; D003863:Depression / Q000209:etiology; D004198:Disease Susceptibility; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects*; D005938:Glucocorticoids; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D011618:Psychotic Disorders / Q000209:etiology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D013312:Stress, Physiological; D013315:Stress, Psychological / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D005938:Glucocorticoids; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger
references: Psychoneuroendocrinology. 2007 May;32(4):376-84
references: 17383826
references: Neuropharmacology. 2012 Jan;62(1):3-12
references: 21807003
references: Nat Neurosci. 2009 Dec;12(12):1559-66
references: 19898468
references: J Neurosci. 1995 Jan;15(1 Pt 1):61-9
references: 7823152
references: Behav Brain Res. 2011 Nov 20;225(1):135-41
references: 21767575
references: Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1774-9
references: 21635931
references: Eur J Neurosci. 2004 Jan;19(1):131-44
references: 14750971
references: Cell Stem Cell. 2011 Feb 4;8(2):164-76
references: 21295273
references: Mol Cell Biol. 2007 Dec;27(24):8466-79
references: 17923682
references: Neuroscience. 1998 Jan;82(2):349-54
references: 9466447
references: J Biol Chem. 2012 Apr 13;287(16):12723-35
references: 22375010
references: Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13806-11
references: 21808001
references: Mol Psychiatry. 2008 Jul;13(7):717-28
references: 17700577
references: Mol Psychiatry. 2013 Sep;18(9):993-1005
references: 22925833
references: Synapse. 2000 Feb;35(2):151-9
references: 10611641
references: Eur J Neurosci. 2003 May;17(9):1928-34
references: 12752792
references: Eur J Neurosci. 2006 Jun;23(11):3051-5
references: 16819994
references: Cereb Cortex. 2014 Jan;24(1):222-31
references: 23042735
references: Biol Psychiatry. 1999 Dec 1;46(11):1472-9
references: 10599477
references: J Neurochem. 2007 May;101(3):815-28
references: 17250652
references: Endocrinology. 2012 Sep;153(9):4317-27
references: 22778218
references: Brain Res. 2006 May 17;1089(1):10-20
references: 16678802
references: Arch Gen Psychiatry. 2006 Nov;63(11):1209-16
references: 17088501
references: Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:240-5
references: 22889863
references: Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20912-7
references: 19934035
references: Behav Brain Res. 2006 Dec 15;175(2):278-84
references: 17014917
references: Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):751-6
references: 18178625
references: J Pediatr Surg. 2010 Oct;45(10):2030-5
references: 20920724
references: J Circadian Rhythms. 2009 Jan 23;7:2
references: 19166596
references: J Neurosci. 1995 Mar;15(3 Pt 1):1768-77
references: 7891134
references: Life Sci. 2011 Feb 14;88(7-8):322-34
references: 21167182
references: Nat Rev Neurosci. 2005 Jun;6(6):463-75
references: 15891777
references: Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):582-7
references: 22184247
references: Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W741-8
references: 15980575
references: Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17657-62
references: 23043114
references: Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10045-50
references: 9294160
references: Eur J Neurosci. 2007 Dec;26(12):3395-401
references: 18052970
references: Endocrinology. 1985 Dec;117(6):2505-11
references: 2998738
references: Eur J Pharmacol. 2008 Apr 7;583(2-3):272-89
references: 18295201
references: Science. 2010 Aug 20;329(5994):959-64
references: 20724638
references: J Neuroendocrinol. 2006 Oct;18(10):732-41
references: 16965291
references: Front Neurosci. 2012 Oct 18;6:135
references: 23087602
references: CNS Neurol Disord Drug Targets. 2006 Oct;5(5):531-46
references: 17073656
references: J Neurosci. 2008 Sep 3;28(36):9055-65
references: 18768700
references: Neuropsychopharmacology. 2009 Oct;34(11):2376-89
references: 19606083
references: Trends Neurosci. 2012 May;35(5):315-24
references: 22386641
references: Hippocampus. 2012 Feb;22(2):359-71
references: 21184481
references: J Biol Chem. 2012 Jul 13;287(29):24195-206
references: 22628545
references: Science. 2009 Oct 16;326(5951):391-5
references: 19833959
references: Neuroscience. 2013 Jun 3;239:214-27
references: 22922121
references: Eur J Neurosci. 2004 Nov;20(10):2541-54
references: 15548198
references: Eur Neuropsychopharmacol. 2011 Sep;21 Suppl 4:S676-82
references: 21835597
references: Mol Cell Neurosci. 1992 Feb;3(1):44-8
references: 19912844
references: Nat Neurosci. 2004 Aug;7(8):847-54
references: 15220929
references: Curr Biol. 2003 Dec 16;13(24):2148-58
references: 14680630
references: Neuroscience. 2005;131(3):647-59
references: 15730870
references: Science. 2003 Dec 5;302(5651):1760-5
references: 14615545
references: Eur Neuropsychopharmacol. 2010 Jan;20(1):1-17
references: 19748235
references: Mol Cell Biol. 2012 Nov;32(22):4628-41
references: 22966208
references: J Neurosci. 2010 Nov 10;30(45):15298-303
references: 21068334
references: Methods. 2001 Dec;25(4):402-8
references: 11846609
references: Nat Neurosci. 2006 Jun;9(6):723-7
references: 16732202
references: Hippocampus. 2006;16(3):233-8
references: 16411244
references: Am J Physiol. 1998 Aug;275(2):L407-13
references: 9700103
references: J Neurochem. 2001 Nov;79(4):826-34
references: 11723175
references: J Cell Biol. 2011 Sep 19;194(6):825-39
references: 21930775
references: Endocrinology. 2012 Nov;153(11):5334-45
references: 22962255
references: PLoS One. 2008 Apr 09;3(4):e1959
references: 18509506
references: Int J Neuropsychopharmacol. 2009 May;12(4):561-78
references: 19224657
references: Neurobiol Learn Mem. 2007 Feb;87(2):303-7
references: 17005423
references: Eur Arch Psychiatry Clin Neurosci. 2007 Aug;257(5):250-60
references: 17401728
references: Prog Neurobiol. 2009 Aug;88(4):246-63
references: 19427352
references: Endocr J. 1995 Oct;42(5):629-36
references: 8574285
references: Eur J Neurosci. 2005 Oct;22(7):1691-700
references: 16197509
references: Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):467-72
references: 11756682
references: Exp Neurol. 2012 Jan;233(1):102-11
references: 22101006
references: Eur J Neurosci. 2001 Aug;14(4):675-89
references: 11556892
references: Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12796-801
references: 11675510
references: Gene. 2007 Aug 1;397(1-2):161-8
references: 17544230
references: J Neurophysiol. 2003 Jan;89(1):625-33
references: 12522207