title: Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation.
abstract: Silymarin, the seed extract of Silybium marianum, has preventive effects against Alzheimer's disease-like pathogenesis in vivo. We isolated (+)-taxifolin (4) from silymarin as an inhibitor of aggregation of the 42-residue amyloid β-protein. Structure-activity relationship studies revealed the 3',4'-dihydroxyl groups to be critical to the anti-aggregative ability, whereas the 7-hydroxyl group and the stereochemistry at positions 2 and 3 were not important.
authors: Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
authors: Mizuho
authors: M
authors: Sato
authors: Kazuma
authors: K
authors: Murakami
authors: Mayumi
authors: M
authors: Uno
authors: Haruko
authors: H
authors: Ikubo
authors: Yu
authors: Y
authors: Nakagawa
authors: Sumie
authors: S
authors: Katayama
authors: Ken-Ichi
authors: K
authors: Akagi
authors: Kazuhiro
authors: K
authors: Irie
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry*; D055503:Protein Multimerization / Q000187:drug effects*; D017433:Protein Structure, Secondary; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012838:Silymarin / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D012838:Silymarin; C075222:amyloid beta-protein (1-42); D011794:Quercetin; C003377:taxifolin