title: Kinetic resolution of β-substituted olefinic carboxylic acids by asymmetric bromolactonization.
abstract: A strategically novel kinetic resolution of β-substituted olefinic carboxylic acids is developed by asymmetric bromolactonization using an organocatalyst, 4-tBuPh-tris 1b. The cyclization stage, which provides δ-lactone, is proposed to be operative for discrimination of each enantiomer of carboxylic acids.
authors: Graduate School of Pharmaceutical Sciences, Osaka University , 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
authors: Kenichi
authors: K
authors: Murai
authors: Tomoyo
authors: T
authors: Matsushita
authors: Akira
authors: A
authors: Nakamura
authors: Norimichi
authors: N
authors: Hyogo
authors: Junki
authors: J
authors: Nakajima
authors: Hiromichi
authors: H
authors: Fujioka
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D007700:Kinetics; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D002264:Carboxylic Acids; D006842:Hydrocarbons, Brominated; D007783:Lactones