title: Electronic beam steering used with a toroidal HIFU transducer substantially increases the coagulated volume.
abstract: Treatment with high-intensity focused ultrasound is well established but requires extended treatment time. A device composed of 256 elements arranged on a toroidal transducer was developed to increase the coagulated volume. When all the elements are working in phase for 40 s, a volume of 6-8 cm(3) can be ablated. However, the mechanical juxtaposition of single lesions is still necessary for treating one tumor with a diameter of 2 cm. The objective of this study was to combine this toroidal transducer geometry with electronic beam steering to ablate tumors with adequate normal tissue margins and without any mechanical displacement of the high-intensity focused ultrasound device. In vitro tests demonstrated that the coagulated volume obtained from 130 s of total exposure has an average diameter of 41.4 ± 4.0 mm and an average length of 53.3 ± 6.1 mm. This single lesion can be used to treat various size of metastasis, located at depths in the liver ranging 5-45 mm.
authors: Université de Lyon and Inserm, Lyon, France. Jeremy.Vincenot@inserm.fr
authors: Jeremy
authors: J
authors: Vincenot
authors: David
authors: D
authors: Melodelima
authors: Françoise
authors: F
authors: Chavrier
authors: Alexandre
authors: A
authors: Vignot
authors: Anthony
authors: A
authors: Kocot
authors: Jean-Yves
authors: JY
authors: Chapelon
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology* / Q000528:radiation effects*; D002417:Cattle; D004867:Equipment Design; D019544:Equipment Failure Analysis; D019220:High-Energy Shock Waves; D057086:High-Intensity Focused Ultrasound Ablation / Q000295:instrumentation*; D066298:In Vitro Techniques; D008099:Liver / Q000502:physiology* / Q000528:radiation effects*; D014159:Transducers