title: Long-term neurodevelopmental and cardiovascular outcome after intrauterine transfusions for fetal anaemia: a review.
abstract: Perinatal survival rates after intrauterine transfusions (IUT) for red cell alloimmunisation now exceed 90%, which demonstrates the safety and efficacy of one of the most successful procedures in fetal therapy. However, improved perinatal survival could lead to an increased number of children with long-term disabilities. The importance of long-term follow-up studies in fetal therapy lies in both the necessity of evaluation of antenatal management as well as in evidence-based preconceptional and prenatal counselling. This review describes the possible long-term cardiovascular and neurodevelopmental sequelae after IUT treatment for different indications including red cell alloimmunisation, parvovirus B19 infection, fetomaternal haemorrhage and twin anaemia-polycythaemia sequence.
authors: Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands. i.t.m.lindenburg@lumc.nl
authors: Irene T M
authors: IT
authors: Lindenburg
authors: Jeanine M
authors: JM
authors: van Klink
authors: Vivianne E H J
authors: VE
authors: Smits-Wintjens
authors: Inge L
authors: IL
authors: van Kamp
authors: Dick
authors: D
authors: Oepkes
authors: Enrico
authors: E
authors: Lopriore
mesh_terms: D000740:Anemia / Q000151:congenital / Q000628:therapy*; D001805:Blood Transfusion, Intrauterine / Q000009:adverse effects; D002320:Cardiovascular Physiological Phenomena; D002648:Child; D002657:Child Development / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D002658:Developmental Disabilities / Q000453:epidemiology / Q000209:etiology; D004899:Erythroblastosis, Fetal / Q000628:therapy; D005260:Female; D005315:Fetal Diseases / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D016896:Treatment Outcome