title: Genetics of hypersensitivity to aspirin and nonsteroidal anti-inflammatory drugs.
abstract: Various hypersensitivity reactions have been reported with aspirin and nonsteroidal anti-inflammatory drugs. Hypersensitivity can occur regardless of a chemical drug structure or its therapeutic potency. Allergic conditions include aspirin-exacerbated respiratory disease (AERD or aspirin-induced asthma), aspirin-induced urticaria/angioedema (AIU), and anaphylaxis. Several genetic studies on aspirin hypersensitivity have been performed to discover the genetic predisposition to aspirin hypersensitivity and to gain insight into the phenotypic diversity. This article updates data on the genetic mechanisms that govern AERD and AIU and summarizes recent findings on the molecular genetic mechanism of aspirin hypersensitivity.
authors: Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Youngtonggu, Suwon, Republic of Korea.
authors: Seung-Hyun
authors: SH
authors: Kim
authors: Marek
authors: M
authors: Sanak
authors: Hae-Sim
authors: HS
authors: Park
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000235:genetics* / Q000276:immunology; D006801:Humans
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin