title: Molecular targeted therapies in non-GIST soft tissue sarcomas: what the radiologist needs to know.
abstract: Non-gastrointestinal stromal soft tissue sarcomas are uncommon neoplasms that have a dismal prognosis due to a high incidence of metastases and a poor response to conventional chemotherapy. The identification of characteristic genetic alterations in several of these tumors has opened the window for molecular targeted therapies in patients who have failed conventional chemotherapy. Imaging plays a critical role in assessing the response to these novel therapeutic agents. Just like the response of gastrointestinal stromal tumors to imatinib, the response of non-gastrointestinal stromal soft tissue sarcomas to molecular targeted drugs is better evaluated on imaging by alternate tumor response criteria such as the Choi criteria. In addition, these drugs are associated with distinct class-specific drug toxicities that can come to attention for the first time on imaging. The purpose of this article is to provide a primer for the radiologist on the various molecular targeted therapies in advanced/metastatic non-gastrointestinal stromal soft tissue sarcomas with emphasis on the role of imaging in assessing treatment response and complications.
authors: Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA. stirumani@partners.org
authors: Sree Harsha
authors: SH
authors: Tirumani
authors: Jyothi P
authors: JP
authors: Jagannathan
authors: Kevin
authors: K
authors: O'Regan
authors: Kyung Won
authors: KW
authors: Kim
authors: Atul B
authors: AB
authors: Shinagare
authors: Katherine M
authors: KM
authors: Krajewski
authors: Nikhil H
authors: NH
authors: Ramaiya
mesh_terms: D001549:Benzamides / Q000627:therapeutic use; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D010879:Piperazines / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use; D011859:Radiography; D012509:Sarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors
chemical_list: D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D058570:TOR Serine-Threonine Kinases
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