title: Carotid body tumors are not associated with an increased risk for sleep-disordered breathing.
abstract: OBJECTIVE
  Tumors in the carotid bodies may interfere with their function as peripheral chemoreceptors. An altered control of ventilation may predispose to sleep-disordered breathing. This study aimed to assess whether patients with unilateral or bilateral carotid body tumors (uCBT or bCBT, respectively) or bilateral CBT resection (bCBR) display sleep-disordered breathing and to evaluate the global contribution of the peripheral chemoreceptor to the hypercapnic ventilatory response.
  
  
  METHODS
  Eight uCBT, eight bCBT, and nine bCBR patients and matched controls underwent polysomnography. The peripheral chemoreflex drive was assessed using euoxic and hyperoxic CO2 rebreathing tests. Daytime sleepiness and fatigue were assessed with the Epworth Sleepiness Scale and the Multidimensional Fatigue Index.
  
  
  RESULTS
  All patient groups reported significant fatigue-related complaints, but no differences in excessive daytime sleepiness (EDS) were found. The apnea/hypopnea index (AHI) did not differ significantly between patient groups and controls. Only in bCBT patients, a trend towards a higher AHI was observed, but this did not reach significance (p=0.06). No differences in the peripheral chemoreflex drive were found between patients and controls.
  
  
  CONCLUSIONS
  Patients with (resection of) CBTs have more complaints of fatigue but are not at risk for EDS. The presence or resection of CBTs is neither associated with an altered peripheral chemoreflex drive nor with sleep-disordered breathing.
authors: Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, the Netherlands, L.T.van_Hulsteijn@lumc.nl.
authors: L T
authors: LT
authors: van Hulsteijn
authors: N
authors: N
authors: van Duinen
authors: M K
authors: MK
authors: Ninaber
authors: J A
authors: JA
authors: Romijn
authors: J G
authors: JG
authors: van Dijk
authors: K W
authors: KW
authors: van Kralingen
authors: B
authors: B
authors: Havekes
authors: L
authors: L
authors: Smid
authors: G J
authors: GJ
authors: Lammers
authors: J C
authors: JC
authors: Jansen
authors: J W
authors: JW
authors: Smit
authors: R D
authors: RD
authors: Thijs
authors: E P M
authors: EP
authors: Corssmit
mesh_terms: D000328:Adult; D000368:Aged; D002345:Carotid Body Tumor / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery; D002628:Chemoreceptor Cells / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D012018:Reflex / Q000502:physiology; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology
chemical_list: D010100:Oxygen
references: Clin Cancer Res. 2011 Jan 15;17(2):247-54
references: 21224366
references: Science. 2000 Feb 4;287(5454):848-51
references: 10657297
references: J Clin Endocrinol Metab. 2006 Mar;91(3):827-36
references: 16317055
references: Respir Physiol. 1982 Dec;50(3):311-33
references: 6819618
references: Head Neck. 2004 Dec;26(12):1058-63
references: 15459923
references: J Appl Physiol Respir Environ Exerc Physiol. 1981 May;50(5):1052-5
references: 6785263
references: Chest. 1978 May;73(5):667-9
references: 648224
references: Eur Respir J. 2005 Oct;26(4):720-35
references: 16204605
references: J Physiol. 2003 Nov 15;553(Pt 1):3-11
references: 14528027
references: Can J Appl Physiol. 1997 Aug;22(4):368-83
references: 9263620
references: Annu Rev Physiol. 2001;63:259-87
references: 11181957
references: J Appl Physiol (1985). 1986 Jun;60(6):1894-9
references: 3087935
references: Prog Cardiovasc Dis. 2009 Mar-Apr;51(5):434-51
references: 19249449
references: Ann Thorac Surg. 1973 Dec;16(6):648-59
references: 4585917
references: J Appl Physiol Respir Environ Exerc Physiol. 1980 Nov;49(5):801-8
references: 6776078
references: Sleep. 1997 Oct;20(10):844-9
references: 9415943
references: PLoS Med. 2007 Jul 24;4(7):e239
references: 17676946
references: Prog Biophys Mol Biol. 2006 Jul;91(3):249-86
references: 16137743
references: J Physiol. 1990 Sep;428:485-99
references: 2121961
references: J Appl Physiol (1985). 1995 Feb;78(2):696-701
references: 7759442
references: Hum Mol Genet. 2010 Aug 1;19(15):3011-20
references: 20484225
references: Nat Genet. 2000 Nov;26(3):268-70
references: 11062460
references: Sleep. 1995 Jan;18(1):53-4
references: 7761743
references: Eur Respir J. 2005 Aug;26(2):319-38
references: 16055882
references: Clin Endocrinol (Oxf). 2011 Nov;75(5):650-5
references: 21561462
references: Sleep Breath. 2012 Jun;16(2):527-34
references: 21614574
references: J Physiol. 2004 Oct 1;560(Pt 1):1-11
references: 15284345
references: J Psychosom Res. 1995 Apr;39(3):315-25
references: 7636775
references: Sleep Med. 2003 Sep;4(5):459-63
references: 14592289
references: J Hypertens. 2003 Mar;21(3):591-9
references: 12640254
references: Am J Hum Genet. 2001 Jul;69(1):49-54
references: 11404820
references: Chest. 2000 Jan;117(1):205-25
references: 10631221
references: Sleep. 1991 Dec;14(6):540-5
references: 1798888
references: JAMA. 2004 Aug 25;292(8):943-51
references: 15328326
references: Am J Surg. 1996 Aug;172(2):196-9
references: 8795531
references: J Appl Physiol (1985). 1993 Nov;75(5):2209-16
references: 8307881