title: Nuclear receptor LXR: a new partner for sodium-dependent phosphate cotransporters.
abstract: New pharmaceutical research approaches are focusing on trying to alleviate the perturbed phosphate (Pi) homeostasis associated with the onset of chronic kidney disease; this includes activation of some of the nuclear receptors. We have recently reported the down regulation of the intestinal and renal sodium-phosphate (NaPi) cotransporters by the liver X receptor (LXR) agonists, and the consequent decrease of the serum Pi levels. In this review, we describe our current knowledge of the different proteins involved in the renal and intestinal actions of LXR.
authors: Division of Renal Diseases and Hypertension, University of Colorado-Denver, 12700 East 19th Avenue, Aurora, CO 80045, USA.
authors: Yupanqui
authors: Y
authors: Caldas
authors: Hector
authors: H
authors: Giral
authors: Victor
authors: V
authors: Sorribas
authors: Moshe
authors: M
authors: Levi
mesh_terms: D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D005966:Glucuronidase / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D054559:Hyperphosphatemia / Q000378:metabolism; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D000090265:Klotho Proteins; D000071518:Liver X Receptors; D051379:Mice; D008954:Models, Biological; D009687:Nuclear Proteins / Q000502:physiology*; D057093:Orphan Nuclear Receptors / Q000172:deficiency / Q000502:physiology*; D010758:Phosphorus / Q000378:metabolism*; D051381:Rats; D015398:Signal Transduction; D012964:Sodium / Q000378:metabolism*; D050608:Sodium-Phosphate Cotransporter Proteins / Q000378:metabolism*
chemical_list: D016207:Cytokines; D000071518:Liver X Receptors; D009687:Nuclear Proteins; D057093:Orphan Nuclear Receptors; D050608:Sodium-Phosphate Cotransporter Proteins; D010758:Phosphorus; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002784:Cholesterol; D012964:Sodium; D005966:Glucuronidase; D000090265:Klotho Proteins