title: Linkage control between molecular and supramolecular chirality in 2₁-helical hydrogen-bonded networks using achiral components.
abstract: Chiral molecules preferentially form one-handed supramolecular assemblies that reflect the absolute configuration of the molecules. Under specific conditions, however, the opposite-handed supramolecular assemblies are also obtained because of flexibility in the bond length and reversibility of non-covalent interactions. The mechanism of the handedness selectivity or switching phenomenon remains ambiguous, and most phenomena are observed by chance. Here we demonstrate the construction of chiral hydrogen-bonded twofold helical assemblies with controlled handedness in the crystalline state based on crystallographic studies. Detailed investigation of the obtained crystal structures enabled us to clarify the mechanism, and the handedness of the supramolecular chirality was successfully controlled by exploiting achiral factors. This study clearly reveals a connection between molecular chirality and supramolecular chirality in the crystalline state.
authors: Department of Material and Life Science, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors: Toshiyuki
authors: T
authors: Sasaki
authors: Ichiro
authors: I
authors: Hisaki
authors: Tetsuya
authors: T
authors: Miyano
authors: Norimitsu
authors: N
authors: Tohnai
authors: Kazuya
authors: K
authors: Morimoto
authors: Hisako
authors: H
authors: Sato
authors: Seiji
authors: S
authors: Tsuzuki
authors: Mikiji
authors: M
authors: Miyata
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