title: Two new diterpenoids from cell cultures of Salvia miltiorrhiza.
abstract: A new spiroketallactone, epi-danshenspiroketallactone A (1) and a new C18-norditerpenoid, normiltioane (2) along with 21 known compounds, were isolated from cell cultures of Salvia miltiorrhiza. Their structures were elucidated on the basis of extensive spectroscopic analyses. In the in vitro assays, the compounds 9-11, 21-23 exhibited the significant antitumor activity with the IC(50) ranges of 1.0-8.3 µM.
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, P.R. China.
authors: De-Wu
authors: DW
authors: Zhang
authors: Xiao
authors: X
authors: Liu
authors: Dan
authors: D
authors: Xie
authors: Ridao
authors: R
authors: Chen
authors: Xiao-Yu
authors: XY
authors: Tao
authors: Jian-Hua
authors: JH
authors: Zou
authors: Jungui
authors: J
authors: Dai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D027561:Salvia miltiorrhiza / Q000737:chemistry* / Q000166:cytology; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes