title: Pomegranate supplementation improves affective and motor behavior in mice after radiation exposure.
abstract: Currently, NASA has plans for extended space travel, and previous research indicates that space radiation can have negative effects on cognitive skills as well as physical and mental health. With long-term space travel, astronauts will be exposed to greater radiation levels. Research shows that an antioxidant-enriched diet may offer some protection against the cellular effects of radiation and may provide significant neuroprotection from the effects of radiation-induced cognitive and behavioral skill deficits. Ninety-six C57BL/6 mice (48 pomegranate fed and 48 control) were irradiated with proton radiation (2 Gy), and two-month postradiation behaviors were assessed using a battery of behavioral tests to measure cognitive and motor functions. Proton irradiation was associated with depression-like behaviors in the tail suspension test, but this effect was ameliorated by the pomegranate diet. Males, in general, displayed worse coordination and balance than females on the rotarod task, and the pomegranate diet ameliorated this effect. Overall, it appears that proton irradiation, which may be encountered in space, may induce a different pattern of behavioral deficits in males than females and that a pomegranate diet may confer protection against some of those effects.
authors: Behavioral Neuroscience Laboratory, Department of Psychology, School of Behavioral Health, Loma Linda University, Suite 106, 11130 Anderson Street, Loma Linda, CA 92350, USA.
authors: Melissa S
authors: MS
authors: Dulcich
authors: Richard E
authors: RE
authors: Hartman
references: In Vitro Cell Dev Biol Anim. 2010 Sep;46(8):718-25
references: 20607620
references: Neuro Endocrinol Lett. 2011;32(1):7-24
references: 21407167
references: Neurobiol Aging. 2005 Dec;26 Suppl 1:128-32
references: 16194581
references: Can J Microbiol. 2005 Jul;51(7):541-7
references: 16175202
references: Afr J Tradit Complement Altern Med. 2008 Oct 25;6(1):49-56
references: 20162041
references: Eur J Pharmacol. 2006 Sep 1;545(1):51-64
references: 16904103
references: J Alzheimers Dis. 2009;18(4):849-65
references: 19661617
references: J Biol Chem. 2008 May 23;283(21):14497-505
references: 18362141
references: Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):265-70
references: 19932727
references: J Ethnopharmacol. 2005 Jan 4;96(1-2):335-9
references: 15588686
references: J Appl Physiol (1985). 2001 Nov;91(5):2374-83
references: 11641383
references: J Nutr. 2001 Aug;131(8):2082-9
references: 11481398
references: Radiat Res. 2008 Dec;170(6):758-64
references: 19138041
references: J Ethnopharmacol. 2004 May;92(1):93-101
references: 15099854
references: Brain Res. 2006 Sep 19;1110(1):102-15
references: 16859659
references: Am J Clin Nutr. 2000 May;71(5):1062-76
references: 10799367
references: Adv Space Res. 1998;22(2):209-16
references: 11541398
references: J Neurosci Methods. 1984 May;11(1):47-60
references: 6471907
references: Exp Anim. 2011;60(2):111-23
references: 21512266
references: Clin Nutr. 2004 Jun;23(3):423-33
references: 15158307
references: Neurobiol Dis. 2006 Dec;24(3):506-15
references: 17010630
references: Surg Neurol Int. 2012;3:19
references: 22439110
references: Auton Neurosci. 2002 Sep 30;100(1-2):66-76
references: 12422962
references: Nature. 2011 Aug 03;476(7361):458-61
references: 21814201
references: Ann N Y Acad Sci. 2007 Apr;1100:470-85
references: 17460212
references: Mech Ageing Dev. 2000 Jul 31;116(2-3):141-53
references: 10996014
references: J Nutr Biochem. 2005 Jun;16(6):360-7
references: 15936648
references: Folia Neuropathol. 2011;49(2):103-8
references: 21845538
references: J Agric Food Chem. 2000 Oct;48(10):4581-9
references: 11052704
references: Psychopharmacology (Berl). 1985;85(3):367-70
references: 3923523
references: Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4896-901
references: 15781875
references: Indian J Exp Biol. 2008 Dec;46(12):811-6
references: 19245177
references: Adv Space Res. 2004;33(8):1334-9
references: 15803624
references: Atherosclerosis. 2006 Sep;188(1):68-76
references: 16332370
references: J Agric Food Chem. 2007 Dec 12;55(25):10405-13
references: 18004807
references: Neurobiol Aging. 2007 Aug;28(8):1187-94
references: 16837106
references: PLoS One. 2010 Sep 16;5(9):
references: 20862278
references: Physiol Behav. 2012 Feb 28;105(4):1092-7
references: 22154805
references: Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):659-63
references: 21376099
references: Behav Brain Res. 2009 Dec 28;205(2):550-8
references: 19703495
references: J Agric Food Chem. 2006 Mar 8;54(5):1928-35
references: 16506855
references: Menopause. 2012 Apr;19(4):426-32
references: 22240636
references: Nutr Neurosci. 2012 Jan;15(1):1-9
references: 22305647