title: Clinical manifestations of heart failure abate with transcatheter aortic paravalvular leak closure using Amplatzer vascular plug II and III devices.
abstract: OBJECTIVE
  To evaluate the transcatheter paravalvular leak closure (TPVLC) aptitude to reduce manifestations of heart failure caused by aortic paravalvular leak (PVL).
  
  
  BACKGROUND
  TPVLC is a valuable alternative to reoperation. While technical feasibility of the method is well established, data on long-term clinical outcome are less abundant.
  
  
  METHODS
  We launched a prospective registry of patients with clinically significant aortic PVL. They were scheduled for TPVLC with Amplatzer vascular plug (AVP) II and III devices serving as occluders. The efficacy and safety were monitored at 6-month follow-up exam.
  
  
  RESULTS
  The occluder deployment reached a success rate of nearly 90%. Following the procedure, we recorded significant improvement both in terms of patient functional capacity and echocardiographic determinants of left ventricular performance. Simultaneously, NT-proBNP plasma concentration and hemolysis markers decreased. Only local complications related to puncture site occurred.
  
  
  CONCLUSIONS
  Heart failure caused by aortic PVL can be safely and efficiently treated with TPVLC using AVP II and III devices as occluders.
authors: 3rd Division of Cardiology, Medical University of Silesia, Katowice, Poland. gsmolka@me.com
authors: Grzegorz
authors: G
authors: Smolka
authors: Piotr
authors: P
authors: Pysz
authors: Wojciech
authors: W
authors: Wojakowski
authors: Andrzej
authors: A
authors: Ochała
authors: Ewa
authors: E
authors: Peszek-Przybyła
authors: Tomasz
authors: T
authors: Roleder
authors: Marek
authors: M
authors: Jasinski
authors: Zbigniew
authors: Z
authors: Gasior
mesh_terms: D000328:Adult; D000368:Aged; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D004452:Echocardiography; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D005471:Fluoroscopy; D005500:Follow-Up Studies; D006333:Heart Failure / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011446:Prospective Studies; D012042:Registries; D055989:Septal Occluder Device; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain