title: N-(guanidinoethyl)-2'-deoxy-5-methylisocytidine exhibits selective recognition of a CG interrupting site for the formation of anti-parallel triplexes.
abstract: The development of novel nucleoside analogues for the formation of triplex DNA containing pyrimidine-purine inversion sites has been a challenging field. In this paper, we describe the design and synthesis of non-natural nucleoside analogues, N-substituted-2'-deoxy-5-methylisocytidine derivatives, and their evaluation for triplex formation. It has been shown that N-(guanidinoethyl)-2'-deoxy-5-methylisocytidine exhibits selective recognition of a CG interrupting site and potentiates the formation of anti-parallel triplexes.
authors: Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Higashiku Maidashi 3-1-1, Japan.
authors: Hidenori
authors: H
authors: Okamura
authors: Yosuke
authors: Y
authors: Taniguchi
authors: Shigeki
authors: S
authors: Sasaki
mesh_terms: D001483:Base Sequence; D003562:Cytidine / Q000138:chemical synthesis / Q000378:metabolism*; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D006146:Guanidines / Q000138:chemical synthesis / Q000378:metabolism*; D009841:Oligonucleotides / Q000235:genetics / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D006146:Guanidines; D009841:Oligonucleotides; C051802:triplex DNA; D003841:Deoxycytidine; D003562:Cytidine; D004247:DNA