title: Allometric scaling relationship between frequency of intestinal contraction and body size in rodents and rabbits.
abstract: This study aimed to establish an allometric scaling relationship between the frequency of intestinal contractions and body mass of different mammalian species. The frequency of intestinal contractions of rabbit, guinea pig, rat and mouse were measured using an isolated organ system. The isolated rings were prepared from proximal segments of jejunums and the frequency of contractions was recorded by an isometric force procedure. The coefficients of the obtained allometric equation were ascertained by computation of least squares after logarithmic transformation of both body mass and frequency. Significant differences (p less than 0.001) were shown in the frequency of contractions between different species. The highest frequency that corresponded to the mice was 57.7 min-1 and the 95 percent confidence interval (CI) ranged from 45.4 to 70, while rabbits showed the lowest frequency (12.71 min-1, CI: 8.6-16.8). Logarithms of frequency were statistically proportional to logarithms of body mass (r00.99; p less than 0.001). The data fitted an equation F 1/4 18:51B 0:31 and the 95 percent confidence interval of the exponent ranged from -0.30 to -0.32. The results of this study suggest that it is probably possible to extrapolate the intestinal contraction frequency of other mammalian species by the means of allometry scaling.
authors: Department of Pharmacology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran. harab@ut.ac.ir
authors: Hossein-Ali
authors: HA
authors: Arab
authors: Samad
authors: S
authors: Muhammadnejad
authors: Saeideh
authors: S
authors: Naeimi
authors: Attieh
authors: A
authors: Arab
mesh_terms: D000818:Animals; D049628:Body Size; D001835:Body Weight; D005769:Gastrointestinal Motility; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007583:Jejunum / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009119:Muscle Contraction; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
references: J Ethnopharmacol. 2010 Jun 16;129(3):377-80
references: 20420890
references: Science. 1949 Jun 10;109(2841):579-85
references: 17835379
references: J Exp Biol. 2005 May;208(Pt 9):1575-92
references: 15855389
references: World J Gastroenterol. 2010 Jul 14;16(26):3239-48
references: 20614479
references: Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4046-9
references: 12637681
references: J Pharm Sci. 1986 Nov;75(11):1028-40
references: 3820096
references: J Pharmacol Exp Ther. 1997 Oct;283(1):46-58
references: 9336307
references: Neurogastroenterol Motil. 2008 Dec;20(12):1306-16
references: 19019033
references: Gastroenterology. 1994 Mar;106(3):649-57
references: 8119536
references: Am J Physiol Gastrointest Liver Physiol. 2012 Apr;302(7):G684-9
references: 22207580