title: [Oxidative stress in Crohn's disease].
abstract: Crohn's disease (CD) is characterized by transmural inflammation that is most frequently located in the region of the terminal ileum. Although the physiopathological mechanisms of the disease are not yet well defined, the unregulated immune response is associated with high production of reactive oxygen species (ROS). These elements are associated with complex systems known as antioxidant defenses, whose function is ROS regulation, thereby preventing the harmful effects of these elements. However, the presence of an imbalance between ROS production and ROS elimination by antioxidants has been widely described and leads to oxidative stress. In this article, we describe the most significant findings on oxidative stress in the intestinal mucosa and peripheral blood.
authors: Instituto de Investigación Sanitaria, Hospital La Fe, Valencia, España; CIBEREHD, España.
authors: Inés
authors: I
authors: Moret
authors: Instituto de Investigación Sanitaria, Hospital La Fe, Valencia, España; Servicio de Medicina Digestiva, Hospital Universitari i Politècnic La Fe, Valencia, España.
authors: Elena
authors: E
authors: Cerrillo
authors: Instituto de Investigación Sanitaria, Hospital La Fe, Valencia, España.
authors: Ana
authors: A
authors: Navarro-Puche
authors: CIBEREHD, España; Servicio de Medicina Digestiva, Hospital Universitari i Politècnic La Fe, Valencia, España.
authors: Marisa
authors: M
authors: Iborra
authors: Instituto de Investigación Sanitaria, Hospital La Fe, Valencia, España; CIBEREHD, España.
authors: Francisco
authors: F
authors: Rausell
authors: Instituto de Investigación Sanitaria, Hospital La Fe, Valencia, España; CIBEREHD, España.
authors: Luis
authors: L
authors: Tortosa
authors: CIBEREHD, España; Servicio de Medicina Digestiva, Hospital Universitari i Politècnic La Fe, Valencia, España. Electronic address: belenbeltranniclos@gmail.com.
authors: Belén
authors: B
authors: Beltrán
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000276:immunology; D002374:Catalase / Q000276:immunology / Q000502:physiology; D003424:Crohn Disease / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D007249:Inflammation; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D007975:Leukotriene B4 / Q000096:biosynthesis; D008214:Lymphocytes / Q000378:metabolism; D019255:NADPH Oxidases / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D018384:Oxidative Stress; D047495:PPAR gamma / Q000819:agonists; D019936:Probiotics / Q000627:therapeutic use; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D001323:Autoantibodies; D047495:PPAR gamma; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D007975:Leukotriene B4; D006861:Hydrogen Peroxide; D002374:Catalase; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II; D019255:NADPH Oxidases
keywords: Catalasa; Catalase; Crohn's disease; Enfermedad de Crohn; Estrés oxidativo; Oxidative stress