title: Introduction of new Tumor Marker Age Score in clinical practice: Validity evaluation for differentiation benign from malignant adnexal masses.
abstract: OBJECTIVE
  The aim of the study was to examine several tumor markers and their correlation with pathohistological findings in patients with adnexal masses.
  
  
  METHODS
  Study involved 139 patients, 84 of them with benign, 47 with malignant and 8 with borderline adnexal tumor. Levels of CA 125, CA 19-9, CEA and CA 15-3 were obtained preoperatively and assessed regarding the specific pathohistological diagnose and the patient's age. Obtaining these results led us to divide the patient's CA 125 levels with age and by doing that we have attained a new Tumor Marker Age score (TMA score).
  
  
  RESULTS
  Patients with malignant adnexal tumors had significantly higher levels of CEA (p<0.05), CA 125, CA 19-9 and CA 15-3 tumor markers (p<0.01), in comparison with patients with benign tumors. TMA score highly statistically correlate with the tumor type (benignant/malignant).
  
  
  CONCLUSIONS
  With the increase of tumor marker levels and the patient's age the malignant nature of adnexal tumors is more often. Results of our study highlight the importance of the use of combined tumor markers (at least CA-125 and CA 19-9) in women with adnexal masses. Those levels along with the patient's age and new TMA score could preoperatively predict malignant nature of the tumor.
authors: Clinical Center of Serbia, Belgrade.
authors: Ivana Likić
authors: IL
authors: Ladjević
authors: Milan
authors: M
authors: Terzić
authors: Nebojsa
authors: N
authors: Ladjević
authors: Jelena
authors: J
authors: Dotlić
authors: Igor
authors: I
authors: Pilić
authors: Jovan
authors: J
authors: Bila
authors: Nebojsa
authors: N
authors: Knezević
authors: Svetlana
authors: S
authors: Milenković
authors: Sanja
authors: S
authors: Maricić
authors: Nebojsa
authors: N
authors: Arsenović
authors: Natasa
authors: N
authors: Brndusić
authors: Branka
authors: B
authors: Nikolić
mesh_terms: D000291:Adnexal Diseases / Q000175:diagnosis*; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D010049:Ovarian Diseases / Q000175:diagnosis*; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor