title: [Potential role of the angiogenic factor "EG-VEGF" in gestational trophoblastic diseases].
abstract: Gestational trophoblastic disease (MGT) includes a wide spectrum of pathologies of the placenta, ranging from benign precancerous lesions, with gestational trophoblastic tumors. Metastases are the leading causes of death as a result of this tumor. They represent a major problem for obstetrics and for the public health system. To date, there is no predictor of the progression of molar pregnancies to gestational trophoblastic tumor (GTT). Only an unfavorable plasma hCG monitoring after evacuation of hydatidiform mole is used to diagnose a TTG. The causes of the development of this cancer are still poorly understood. Increasing data in the literature suggests a close association between the development of this tumor and poor placental vascularization during the first trimester of pregnancy. The development of the human placenta depends on a coordination between the trophoblast and endothelial cells. A disruption in the expression of angiogenic factors could contribute to uterine or extra-uterine tissue invasion by extravillous trophoblast, contributing to the development of TTG. This review sheds lights on the phenomenon of angiogenesis during normal and abnormal placentation, especially during the MGT and reports preliminary finding concerning, the variability of expression of "Endocrine Gland-Derived Vascular Endothelial Growth Factor" (EG-VEGF), a specific placental angiogenic factor, in normal and molar placentas, and the potential role of differentiated expressions of the main placental angiogenic factors in the scalability of hydatidiform moles towards a recovery or towards the development of gestational trophoblastic tumor. Deciphering the mechanisms by which the angiogenic factor influences these processes will help understand the pathophysiology of MGT and to create opportunities for early diagnosis and treatment of the latter.
authors: 29, lotissement Abdelmoumen, résidence Al Mokhtar, 20340 Casablanca, Maroc; Centre d'études doctorales, formation doctorale en génétique et biologie moléculaire, faculté de médecine et de pharmacie, université Aïn Chok, Casablanca, Maroc; Service de gynécologie-obstétrique « C », faculté de médecine et de pharmacie, université Aïn Chok, CHU Ibn Rochd, Casablanca, Maroc. Electronic address: mohcineb@yahoo.fr.
authors: H
authors: H
authors: Boufettal
authors: J-J
authors: JJ
authors: Feige
authors: M
authors: M
authors: Benharouga
authors: T
authors: T
authors: Aboussaouira
authors: S
authors: S
authors: Nadifi
authors: S
authors: S
authors: Mahdaoui
authors: N
authors: N
authors: Samouh
authors: N
authors: N
authors: Alfaidy
mesh_terms: D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D006828:Hydatidiform Mole / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000502:physiology; D010920:Placenta / Q000098:blood supply; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000503:physiopathology; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / Q000502:physiology*
chemical_list: D006063:Chorionic Gonadotropin; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
keywords: Angiogenesis; Angiogenèse; Chorionic gonadotropin hormones; EG-VEGF; Hormones gonadotrophines chorioniques; Maladies trophoblastiques; Placenta; Prokineticin; Trophoblastic diseases; Trophoblastic tumors; Tumeurs trophoblastiques