title: Functional ribosome biogenesis is a prerequisite for p53 destabilization: impact of chemotherapy on nucleolar functions and RNA metabolism.
abstract: The production and processing of ribosomal RNA is a complex and well-coordinated nucleolar process for ribosome biogenesis. Progress in understanding nucleolar structure and function has lead to the unexpected discovery of the nucleolus as a highly sensitive sensor of cellular stress and an important regulator of the tumor suppressor p53. Inhibition of ribosomal RNA metabolism has been shown to activate a signaling pathway for p53 induction. This review elucidates the potential of classical and recently developed chemotherapeutic drugs to stabilize p53 by inhibiting nucleolar functions.
authors: Department of Molecular Epigenetics, Helmholtz Zentrum München and Center for Integrated Protein Science Munich, Marchioninistrasse 25, 81377 Munich, Germany.
authors: Kaspar
authors: K
authors: Burger
authors: Dirk
authors: D
authors: Eick
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000235:genetics / Q000378:metabolism; D006801:Humans; D014176:Protein Biosynthesis; D012313:RNA / Q000235:genetics / Q000378:metabolism*; D012269:Ribosomal Proteins / Q000235:genetics / Q000378:metabolism*; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D012269:Ribosomal Proteins; D016159:Tumor Suppressor Protein p53; D012313:RNA