title: Anti-inflammatory and anti-oxidative effects of corilagin in a rat model of acute cholestasis.
abstract: BACKGROUND
  Nowadays, treatments for cholestasis remain largely nonspecific and often ineffective. Recent studies showed that inflammatory injuries and oxidative stress occur in the liver with cholestasis. In this study, we would use corilagin to treat the animal model of acute cholestasis in order to define the activity to interfere with inflammation-related and oxidative stress pathway in cholestatic pathogenesis.
  
  
  METHODS
  Rats were administrated with alpha-naphthylisothiocyanate to establish model of cholestasis and divided into corilagin, ursodeoxycholic acid, dexamethasone, model and normal groups with treatment of related agent. At 24h, 48h and 72h time points after administration, living condition, serum markers of liver damage, pathological changes of hepatic tissue, nuclear factor (NF)-kappaB, myeloperoxidase (MPO), malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) were examined and observed.
  
  
  RESULTS
  Compared to model group, corilagin had remarkable effect on living condition, pathological manifestation of liver tissue, total bilirubin, direct bilirubin, (P<0.01), but no effect on alanine aminotransferase (ALT) and aspartate aminotransferase (AST). With corilagin intervention, levels of MPO, MDA and translocation of NF-κB were notably decreased, and levels of SOD and NO were markedly increased (P<0.05 or P<0.01).
  
  
  CONCLUSIONS
  It is shown that corilagin is a potential component to relieve cholestasis through inflammation-related and oxidation-related pathway.
authors: Department of Neurosurgery, Neuro-oncology Laboratory, Affiliated Hospitalof Jining Medical College, Jining, Shandong 272029, PR China.
authors: Feng
authors: F
authors: Jin
authors: Du
authors: D
authors: Cheng
authors: Jun-Yan
authors: JY
authors: Tao
authors: Shu-Ling
authors: SL
authors: Zhang
authors: Ran
authors: R
authors: Pang
authors: Yuan-Jin
authors: YJ
authors: Guo
authors: Pian
authors: P
authors: Ye
authors: Ji-Hua
authors: JH
authors: Dong
authors: Lei
authors: L
authors: Zhao
mesh_terms: D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D002779:Cholestasis / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D005960:Glucosides / Q000494:pharmacology* / Q000627:therapeutic use*; D047348:Hydrolyzable Tannins; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D016328:NF-kappa B / Q000096:biosynthesis; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D014580:Ursodeoxycholic Acid / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D002756:Cholagogues and Choleretics; D005960:Glucosides; D047348:Hydrolyzable Tannins; D016328:NF-kappa B; D009569:Nitric Oxide; D008315:Malondialdehyde; C049096:corilagin; D014580:Ursodeoxycholic Acid; D003907:Dexamethasone; D009195:Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin
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