title: Memory and motor coordination improvement by folic Acid supplementation in healthy adult male rats.
abstract: OBJECTIVE
  Previous studies have shown that vitamin B as well as folate supplementation has been implicated in cognitive and neurodegenerative disorders including Alzheimer's and Parkinson's diseases. The aim of present study was to evaluate the effects of folic acid on passive avoidance task and motor coordination in healthy adult male rats.
  
  
  METHODS
  Animals were randomly divided into five groups with 10 in each. 1) Sham treated (Veh); received same volume of normal saline as folate vehicle, 2-5) Test groups; each received a single dose of folate (5, 10 and 15 mg/ml/kg, IP daily for one week). At the end of the treatment with folic acid or vehicle, motor coordination in rotarod (after 24 hr) and passive avoidance memory in shuttle box (after 2 and 30 days) were evaluated, respectively.
  
  
  RESULTS
  The results showed that folic acid (5, 10, and 15 mg/kg) increased short-term (P<0.05, P<0.001) memory while, long term memory affected significantly with doses 10 and 15 mg/kg (P<0.01, P<0.001). On the other hand, folic acid (5 and 10 mg/kg) had significant improving effect on motor coordination (P<0.001, P<0.01) but with 15 mg/kg dose didn't have any effect on motor coordination.
  
  
  CONCLUSIONS
  Our results suggest that folic acid may improve both short- and long-term memories, dose dependently, although it affects motor balance at lower dose. The mechanism of folic acid effects on cognition and motor coordination is unknown and needs more investigations.
authors: Department of Biology, Faculty of Sciences, Shahid Chamran University, Ahvaz, Iran.
authors: Maryam Khombi
authors: MK
authors: Shooshtari
authors: Ahmad Ali
authors: AA
authors: Moazedi
authors: Gholam Ali
authors: GA
authors: Parham
keywords: Folic acid; Memory; Motor coordination; Rat
references: J Neurochem. 2002 Jan;80(1):101-10
references: 11796748
references: Ageing Res Rev. 2002 Feb;1(1):95-111
references: 12039451
references: Prostaglandins Leukot Essent Fatty Acids. 2008 Jan;78(1):11-9
references: 18054217
references: Neuroscience. 2003;116(4):1131-40
references: 12617954
references: Neuropharmacology. 2008 Feb;54(2):464-73
references: 18078962
references: J Am Coll Nutr. 2006 Dec;25(6):502-8
references: 17229897
references: Am J Clin Nutr. 2007 Jan;85(1):193-200
references: 17209196
references: Ann Neurol. 2004 Aug;56(2):221-7
references: 15293274
references: J Korean Med Sci. 2010 Nov;25(11):1638-45
references: 21060754
references: Br J Pharmacol. 1993 Oct;110(2):753-60
references: 8242248
references: Drug Metab Lett. 2007 Jan;1(1):55-60
references: 19356019
references: Am J Clin Nutr. 2005 Dec;82(6):1346-52
references: 16332669
references: Brain Res Bull. 2006 Apr 14;69(3):318-26
references: 16564428
references: Altern Med Rev. 1998 Jun;3(3):208-20
references: 9630738
references: Prog Neuropsychopharmacol Biol Psychiatry. 2005 Sep;29(7):1152-61
references: 16102882
references: Arch Neurol. 2007 Jan;64(1):86-92
references: 17210813
references: J Neurol Sci. 2007 Jun 15;257(1-2):31-7
references: 17336337
references: Arch Gerontol Geriatr. 2006 Jul-Aug;43(1):127-37
references: 16359741
references: Circulation. 1996 Jan 1;93(1):7-9
references: 8616944
references: Lancet Neurol. 2006 Nov;5(11):949-60
references: 17052662
references: Neurochem Int. 2005 Feb;46(3):221-5
references: 15670638
references: Neurol India. 2004 Sep;52(3):310-8
references: 15472418
references: J Nutr. 2008 Dec;138(12):2502-9
references: 19022979
references: Lancet. 2007 Jan 20;369(9557):208-16
references: 17240287
references: Am J Epidemiol. 2004 Aug 15;160(4):368-75
references: 15286022
references: Am J Clin Nutr. 2007 Sep;86(3):728-34
references: 17823439
references: Am J Clin Nutr. 2005 Sep;82(3):636-43
references: 16155278
references: Neurobiol Aging. 2006 Feb;27(2):334-43
references: 16399216
references: Trends Neurosci. 2003 Mar;26(3):137-46
references: 12591216
references: Am J Clin Nutr. 2005 Sep;82(3):627-35
references: 16155277
references: Brain Res. 2008 Jan 10;1188:122-31
references: 18061153