title: IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations.
abstract: Genetic variation in immune-related genes, such as IL10 and TNF, have been associated with the development of non-Hodgkin lymphoma (NHL) in Caucasian populations. To test the hypothesis that IL10 and TNF polymorphisms may be associated with NHL risk in Asian populations, we genotyped 20 single nucleotide polymorphisms (SNPs) within the IL10 and TNF/LTA loci in three independent case-control studies (2635 cases and 4234 controls). IL10 rs1800871, rs1800872, and rs1800896 were genotyped in all three studies, while 5 of the remaining SNPs were genotyped in two studies, and 12 in a single study. IL10 rs1800896 was associated with B cell lymphoma [per-allele odds ratio (OR) = 1.25, 95 % confidence interval (CI) 1.08-1.45; p trend = 0.003], specifically diffuse large B cell lymphoma (DLBCL) (per-allele OR = 1.29, 95 % CI 1.08-1.53; p trend = 0.004), as well as T cell lymphoma (per-allele OR = 1.44, 95 % CI 1.13-1.82; p trend = 0.003). TNF rs1800629, which was genotyped in only two of our studies, was also associated with B cell lymphoma (per-allele OR = 0.77, 95 % CI 0.64-0.91; p trend = 0.003), specifically DLBCL (per-allele OR = 0.69, 95 % CI 0.55-0.86; p trend = 0.001). Our findings suggest that genetic variation in IL10 and TNF may also play a role in lymphomagenesis in Asian populations.
authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute,NIH/DHHS, Bethesda, MD, USA. dean.hosgood@einstein.yu.edu
authors: H Dean
authors: HD
authors: Hosgood
authors: Wing-Yan
authors: WY
authors: Au
authors: Hee Nam
authors: HN
authors: Kim
authors: Jie
authors: J
authors: Liu
authors: Wei
authors: W
authors: Hu
authors: Jovic
authors: J
authors: Tse
authors: Bao
authors: B
authors: Song
authors: Kit-Fai
authors: KF
authors: Wong
authors: Je-Jung
authors: JJ
authors: Lee
authors: Stephen J
authors: SJ
authors: Chanock
authors: L P
authors: LP
authors: Siu
authors: Mark P
authors: MP
authors: Purdue
authors: Min-Ho
authors: MH
authors: Shin
authors: Jinming
authors: J
authors: Yu
authors: Raymond
authors: R
authors: Liang
authors: Hyeoung-Joon
authors: HJ
authors: Kim
authors: Nathaniel
authors: N
authors: Rothman
authors: Qing
authors: Q
authors: Lan
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea / Q000453:epidemiology; D012306:Risk; D048069:Tumor Necrosis Factors / Q000235:genetics*
chemical_list: D048069:Tumor Necrosis Factors; D016753:Interleukin-10
references: Hum Immunol. 2002 Nov;63(11):1055-61
references: 12392859
references: Clin Immunol. 2003 Nov;109(2):119-29
references: 14597210
references: Front Oncol. 2012 Jan 10;1:53
references: 22649769
references: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references: 21296855
references: Leuk Lymphoma. 2003 Feb;44(2):251-5
references: 12688341
references: Eur J Haematol. 2010 Dec;85(6):492-5
references: 20731705
references: Ann Hematol. 2005 Jan;84(1):1-12
references: 15480663
references: Lancet Oncol. 2006 Jan;7(1):27-38
references: 16389181
references: Blood. 1998 May 15;91(10):3574-81
references: 9572991
references: Science. 2004 Dec 3;306(5702):1774-6
references: 15576619
references: Blood. 2007 Apr 15;109(8):3479-88
references: 17185468
references: Genes Immun. 2009 Oct;10(7):607-15
references: 19536152
references: Immunogenetics. 2007 Nov;59(11):839-52
references: 17938902
references: Am J Epidemiol. 2010 Feb 1;171(3):267-76
references: 20047977
references: Curr Opin Allergy Clin Immunol. 2002 Dec;2(6):495-506
references: 14752332
references: Blood. 1993 Oct 1;82(7):2169-74
references: 8400266