title: Quality of life after management of advanced osteoradionecrosis of the mandible.
abstract: Osteoradionecrosis (ORN) of the mandible is a severe complication of radiation therapy for head and neck cancer. In this case series, the authors analyzed their treatment and quality of life outcomes over the past 6 years. A retrospective chart review of 42 patients treated surgically for advanced ORN was conducted. A telephone survey was conducted and quality of life (QOL) questionnaires were completed in a subset of patients. 30 patients responded to the telephone survey assessing QOL for speech, swallowing and overall functioning correlated with oral nutrition and performance status. Surgery for ORN can result in an improved QOL. Functional outcomes of oral intake, speech intelligibility, and eating in public correlated with patient rated QOL measures. A lack of improvement in QOL, despite the restoration of an intact mandible, relates to the persistent effects of chemoradiotherapy.
authors: Department of Otolaryngology, Head and Neck Surgery, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY, USA. ajacobson@chpnet.org
authors: A S
authors: AS
authors: Jacobson
authors: J
authors: J
authors: Zevallos
authors: M
authors: M
authors: Smith
authors: C L
authors: CL
authors: Lazarus
authors: H
authors: H
authors: Husaini
authors: D
authors: D
authors: Okay
authors: D
authors: D
authors: Buchbinder
authors: M
authors: M
authors: Persky
authors: M L
authors: ML
authors: Urken
mesh_terms: D000368:Aged; D016025:Bone Transplantation / Q000379:methods; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003679:Deglutition / Q000502:physiology; D004435:Eating / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D058752:Free Tissue Flaps / Q000637:transplantation; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D006987:Hypesthesia / Q000209:etiology; D007398:Interpersonal Relations; D008297:Male; D008336:Mandibular Diseases / Q000523:psychology* / Q000601:surgery; D063175:Mandibular Reconstruction / Q000295:instrumentation / Q000379:methods; D008875:Middle Aged; D010025:Osteoradionecrosis / Q000523:psychology* / Q000601:surgery; D010147:Pain Measurement; D010149:Postoperative Pain / Q000209:etiology; D011183:Postoperative Complications; D011788:Quality of Life; D012189:Retrospective Studies; D013060:Speech / Q000502:physiology; D013065:Speech Intelligibility / Q000502:physiology; D016896:Treatment Outcome; D014313:Trismus / Q000209:etiology
keywords: functional outcomes; mandible reconstruction; osteoradionecrosis; quality of life; radiation therapy