title: Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis.
abstract: Heavy neurofilaments (NFH) released from neurons during axonal injury induce a humoral immune response. We measured CSF and serum levels of NFH proteins and anti-NFH IgG antibodies in 19 patients with clinically isolated syndrome (CIS) converting to multiple sclerosis, in 20 stable CIS patients, 23 patients with multiple sclerosis (MS) and 32 control subjects using ELISA. CSF and intrathecal levels and CSF/serum ratios of anti-NFH antibodies were increased in the CIS patients early developing MS while NFH protein concentrations were similar among the groups. Changes associated with NFH are more pronounced for antibodies than for protein itself and may aid in prediction of CIS patients.
authors: Charles University in Prague, First Faculty of Medicine and General Teaching Hospital, Institute of Medical Biochemistry and Laboratory Diagnostics, Kateřinská 32, 121 08 Prague 2, Czech Republic.
authors: Lenka
authors: L
authors: Fialová
authors: Ales
authors: A
authors: Bartos
authors: Jana
authors: J
authors: Švarcová
authors: Denisa
authors: D
authors: Zimova
authors: Jolana
authors: J
authors: Kotoucova
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000276:immunology; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D008137:Longitudinal Studies; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology*; D016900:Neurofilament Proteins / Q000276:immunology*; D011379:Prognosis; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D016900:Neurofilament Proteins; C051774:neurofilament protein H