title: Association between genetic variants of the VEGFR-2 gene and the risk of developing endometriosis in Northern Chinese Women.
abstract: OBJECTIVE
  To investigate the association of tag single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor receptor 2 (VEGFR-2) gene with susceptibility to endometriosis.
  
  
  METHODS
  This study comprised 571 patients with endometriosis and 580 women in the control group. Five tag SNPs in the VEGFR-2 gene were selected using a Haploview program, and those SNPs were genotyped by a method of polymerase chain reaction and ligase detection reaction.
  
  
  RESULTS
  Statistical results show that there was a significant difference in the genotype and allele distribution of the 1192C/T polymorphism between the disease group and the control group (p = 0.041 and 0.017). The women carrying the T allele (C/T+T/T genotype) had a lower risk of developing endometriosis compared with the women with the C/C genotype (OR 0.75, 95% CI 0.57-0.99). There was no significant difference in the allele and genotype distribution of four other tag SNPs (1719T/A, +31C/T, IVS25-92A/G and IVS6+​54C/T) between the disease group and the control group (all p > 0.05).
  
  
  CONCLUSIONS
  Our results suggested that the 1192C/T polymorphisms on the VEGFR-2 gene might affect the risk of developing endometriosis in Northern Chinese women of Han ethnicity.
authors: Department of Obstetrics and Gynecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China. ksjq62cn@sina.com
authors: Shan
authors: S
authors: Kang
authors: Yuan-yuan
authors: YY
authors: Shi
authors: Yan
authors: Y
authors: Li
authors: Na
authors: N
authors: Wang
authors: Yu-chao
authors: YC
authors: Lu
authors: Rong-miao
authors: RM
authors: Zhou
authors: Xi-wa
authors: XW
authors: Zhao
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004715:Endometriosis / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics*
chemical_list: D004247:DNA; D040301:Vascular Endothelial Growth Factor Receptor-2