title: Social cognitive role of schizophrenia candidate gene GABRB2.
abstract: The occurrence of positive selection in schizophrenia-associated GABRB2 suggests a broader impact of the gene product on population fitness. The present study considered the possibility of cognition-related GABRB2 involvement by examining the association of GABRB2 with psychosis and altruism, respectively representing psychiatric and psychological facets of social cognition. Four single nucleotide polymorphisms (SNPs) were genotyped for quantitative trait analyses and population-based association studies. Psychosis was measured by either the Positive and Negative Syndrome Scale (PANSS) or antipsychotics dosage, and altruism was based on a self-report altruism scale. The minor alleles of SNPs rs6556547, rs1816071 and rs187269 in GABRB2 were correlated with high PANSS score for positive symptoms in a Han Chinese schizophrenic cohort, whereas those of rs1816071 and rs1816072 were associated with high antipsychotics dosage in a US Caucasian schizophrenic cohort. Moreover, strongly significant GABRB2-disease associations were found among schizophrenics with severe psychosis based on high PANSS positive score, but no significant association was observed for schizophrenics with only mild psychosis. Interestingly, in addition to association with psychosis in schizophrenics, rs187269 was also associated with altruism in healthy Han Chinese. Furthermore, parallel to correlation with severe psychosis, its minor allele was correlated with high altruism scores. These findings revealed that GABRB2 is associated with psychosis, the core symptom and an endophenotype of schizophrenia. Importantly, the association was found across the breadth of the psychiatric (psychosis) to psychological (altruism) spectrum of social cognition suggesting GABRB2 involvement in human cognition.
authors: Division of Life Science and Applied Genomics Laboratory, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
authors: Shui Ying
authors: SY
authors: Tsang
authors: Songfa
authors: S
authors: Zhong
authors: Lingling
authors: L
authors: Mei
authors: Jianhuan
authors: J
authors: Chen
authors: Siu-Kin
authors: SK
authors: Ng
authors: Frank W
authors: FW
authors: Pun
authors: Cunyou
authors: C
authors: Zhao
authors: Bingyi
authors: B
authors: Jing
authors: Robin
authors: R
authors: Chark
authors: Jianhua
authors: J
authors: Guo
authors: Yunlong
authors: Y
authors: Tan
authors: Lijun
authors: L
authors: Li
authors: Chuanyue
authors: C
authors: Wang
authors: Soo Hong
authors: SH
authors: Chew
authors: Hong
authors: H
authors: Xue
mesh_terms: D000328:Adult; D000483:Alleles; D000533:Altruism; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003071:Cognition; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D005787:Gene Frequency; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D019655:Quantitative Trait, Heritable; D011963:Receptors, GABA-A / Q000235:genetics* / Q000378:metabolism; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; C495710:GABRB2 protein, human; D011963:Receptors, GABA-A
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