title: Physicochemical characterization of the comb-type pyridine-co-poly(ethylene glycol) copolymer at the interface.
abstract: The novel amphiphilic comb-type copolymers were synthesized by copolymerization of a unit A that contains a pyridine (Py) portion and a unit B that contains a poly(ethylene glycol) (PEG) portion. The obtained copolymers consist of methoxy-endend PEG as a hydrophiphilic segment and Py as a hydrophobic and metal affinity segment (Py-co-PEG). Py-co-PEGs formed micelles and their physicochemical properties were intensively investigated in terms of critical micelle concentration, pyrene solubilization, and micelle size distribution. Furthermore, the gold nanoparticles (Au-NPs) were prepared using the Py-co-PEG polymeric micelles. Py-co-PEG has attained the long term interfacial stability by employing the multi-point adsorption of the Py unit on the gold surface, although usually prepared Au-NPs by thiol derivative are well-known to readily lose the dispersion stability under physiological and oxidative condition. It is important to note that Au-NPs protected by Py-co-PEG were drastically enhanced their dispersion stability under high ionic physiological and air oxidative conditions.
authors: Faculty of Science, Department of Applied Chemistry Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
authors: Hidenori
authors: H
authors: Otsuka
authors: Masayuki
authors: M
authors: Fukaishi
authors: Takashi
authors: T
authors: Ishizuka
authors: Yoshihiro
authors: Y
authors: Saito
mesh_terms: D006046:Gold / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D011725:Pyridines; D011092:Polyethylene Glycols; D006046:Gold; C023666:pyridine