title: Tamoxifen citrate loaded ethosomes for transdermal drug delivery system: preparation and characterization.
abstract: Long term tamoxifen citrate therapy is imperative to treat several dermatological and hormonal sensitive disorders. Successful oral and parenteral administration of tamoxifen citrate has been challenging since it undergoes enzymatic degradation and has poor aqueous solubility issues. In the present work, tamoxifen citrate loaded ethosomes were prepared and characterized for transdermal applications. The prepared formulations were characterized for morphological features, particle size distribution, calorimetric attributes, zeta potential and drug entrapment. Permeation profile of prepared ethosomes was compared with liposomes and hydroethonalic solution across cellophane membrane and human cadaver skin. Results of the permeation studies indicate that ethosomes were able to deliver >90% drug within 24 hours of application, while liposomes and hydroethanolic solution delivered only 39.04% and 36.55% respectively. Skin deposition and stability studies are also reported.
authors: University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, India 492010. preetisuresh@ymail.com
authors: Khomendra Kumar
authors: KK
authors: Sarwa
authors: Preeti K
authors: PK
authors: Suresh
authors: Manabendra
authors: M
authors: Debnath
authors: Mohammad Zaki
authors: MZ
authors: Ahmad
mesh_terms: D000279:Administration, Cutaneous; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D004339:Drug Compounding; D004965:Estrogen Antagonists / Q000008:administration & dosage* / Q000737:chemistry; D000431:Ethanol / Q000737:chemistry*; D006801:Humans; D066298:In Vitro Techniques; D008081:Liposomes; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013499:Surface Properties; D013629:Tamoxifen / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D018931:Antineoplastic Agents, Hormonal; D004965:Estrogen Antagonists; D008081:Liposomes; D010713:Phosphatidylcholines; C585968:phospholipon 90G; D013629:Tamoxifen; D000431:Ethanol