title: Plasmon based biosensor for distinguishing different peptides mutation states.
abstract: Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.
authors: Nanostructures, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy. gobind.das@iit.it
authors: Gobind
authors: G
authors: Das
authors: Manohar
authors: M
authors: Chirumamilla
authors: Andrea
authors: A
authors: Toma
authors: Anisha
authors: A
authors: Gopalakrishnan
authors: Remo Proietti
authors: RP
authors: Zaccaria
authors: Alessandro
authors: A
authors: Alabastri
authors: Marco
authors: M
authors: Leoncini
authors: Enzo
authors: E
authors: Di Fabrizio
mesh_terms: D019313:BRCA1 Protein / Q000737:chemistry / Q000235:genetics; D015374:Biosensing Techniques / Q000379:methods*; D006046:Gold / Q000737:chemistry; D009154:Mutation; D009211:Myoglobin / Q000737:chemistry / Q000235:genetics; D049329:Nanostructures / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry; D020349:Surface Plasmon Resonance / Q000379:methods*
chemical_list: D019313:BRCA1 Protein; D009211:Myoglobin; D010455:Peptides; D012235:Rhodamines; C026188:rhodamine 6G; D006046:Gold
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