title: Urinary PGE-M: a promising cancer biomarker.
abstract: Cancer prevention, early diagnosis, and targeted therapies are the keys to success in better cancer control and treatment. A big challenge remains to identify biomarkers for predicting who may have higher cancer risk and are able to respond to certain chemopreventive agents as well as for assessing a patient's response during treatment. Although a large body of evidence indicates that chronic inflammation is a risk factor for cancer, it is unclear whether inflammatory biomarkers can be used to predict cancer risk, progression, and death. Considering the importance of the proinflammatory COX-2-derived prostaglandin E2 (PGE2) in inflammation and cancer, Morris and colleagues found that urinary PGE-M is positively associated with obesity, smoking, and lung metastases in patients with breast cancer (4). Along the same lines, Kim and colleagues showed a potential association between urinary PGE-M and breast cancer risk in postmenopausal women (beginning on page 511). In agreement with previous reports, their findings indicate that urinary PGE-M may serve as a promising biomarker for prognosticating cancer risk and disease progression.
authors: Center of Inflammation and Cancer, Biodesign Institute of Arizona State University, 727 E. Tyler Street, Tempe, AZ 85287, USA.
authors: Dingzhi
authors: D
authors: Wang
authors: Raymond N
authors: RN
authors: DuBois
mesh_terms: D014408:Biomarkers, Tumor / Q000652:urine*; D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D009765:Obesity / Q000150:complications*; D017698:Postmenopause / Q000187:drug effects*
chemical_list: D014408:Biomarkers, Tumor
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