title: Malignant peripheral nerve sheath tumor of non-neurofibromatosis type I metastasized to the cerebrospinal axis.
abstract: A malignant peripheral nerve sheath tumor (MPNST) is a type of sarcoma that arises from peripheral nerves or cells of the associated nerve sheath. This tumor most commonly metastasizes to the lung and metastases to the spinal cord and brain are very rare. We describe a case of young patient with spinal cord and brain metastases resulting from MPNST. An 18-year-old man presented with a 6-month history of low back pain and radiating pain to his anterior thigh. Magnetic resonance imaging showed a paraspinal mass that extended from the central space of L2 to right psoas muscle through the right L2-3 foraminal space. The patient underwent surgery and the result of the histopathologic study was diagnostic for MPNST. Six months after surgery, follow-up images revealed multiple spinal cord and brain metastases. The patient was managed with chemotherapy, but died several months later. Despite complete surgical excision, the MPNST progressed rapidly and aggressively. Thus, patients with MPNST should be followed carefully to identify local recurrence or metastasis as early as possible.
authors: Department of Neurosurgery, Kyungpook National University Hospital, Daegu, Korea.
authors: Man-Kyu
authors: MK
authors: Park
authors: Joo-Kyung
authors: JK
authors: Sung
authors: Kyung-Hun
authors: KH
authors: Nam
authors: Kyoung-Tae
authors: KT
authors: Kim
keywords: Brain metastasis; Malignant peripheral nerve sheath tumors; Spinal cord metastasis
references: Clin Neuropathol. 2004 Sep-Oct;23(5):245-55
references: 15581029
references: Pediatr Dev Pathol. 2005 Mar-Apr;8(2):235-9
references: 15827834
references: J Neurooncol. 2005 Sep;74(2):183-5
references: 16193390
references: Int J Clin Oncol. 2005 Oct;10(5):353-6
references: 16247664
references: J Korean Neurosurg Soc. 2008 Aug;44(2):91-4
references: 19096700
references: J Clin Oncol. 1998 Jan;16(1):197-203
references: 9440743
references: Cancer. 1990 Sep 15;66(6):1253-65
references: 2119249
references: Cancer. 1986 May 15;57(10):2006-21
references: 3082508
references: J Bone Joint Surg Br. 2004 Jan;86(1):113-5
references: 14765877
references: Spine (Phila Pa 1976). 2004 Nov 1;29(21):E506-9
references: 15507791
references: Cancer. 1998 Jun 1;82(11):2191-203
references: 9610699
references: Int J Radiat Oncol Biol Phys. 1998 Sep 1;42(2):351-60
references: 9788415
references: J Neurosurg. 2005 Oct;103(4):760-3
references: 16266062
references: Neurology. 2003 Sep 9;61(5):696-8
references: 12963767