title: [Systems of genes and proteins affecting mycobacteria virulence and their homologs participation in conjugation of mycobacterium smegmatis].
abstract: This review describes and summarizes the data of ESX secretory system peculiarities characteristic of mainly mycobacteria. This system is involved in the secretion of small proteins of the WXG100 family. Some of these proteins represent virulence factors of Mycobacterium tuberculosis and other pathogenic mycobacteria. The role of these proteins in pathogenesis apparently consists of protecting mycobacteria from lysis in the macrophages that absorb them; the cytolysis of macrophages; and, hence, mycobacterium output into the surrounding tissue. A number of proteins that make up this secretory system are homologs of proteins involved in the conjugation process in saprophytic Mycobacterium smegmatis.
authors: Vavilov Institute of General Genetics, RAS, Moscow Russia
authors: A A
authors: AA
authors: Prozorov
authors: M V
authors: MV
authors: Zaichikova
authors: V N
authors: VN
authors: Danilenko
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics*; D005089:Exocytosis / Q000235:genetics; D005798:Genes, Bacterial; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D009161:Mycobacterium / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity; D020102:Mycobacterium smegmatis / Q000235:genetics; D014774:Virulence / Q000235:genetics
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins