title: Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old.
abstract: Inherited genetic variation of mitochondrial DNA (mtDNA) could account for the missing heritability of human longevity and healthy aging. Here, we show no robust association between common genetic variants of mtDNA and frailty (an "unhealthy aging" phenotype) or mortality in 700, more than 85-year-old, participants of the Newcastle 85+ study. Conflicting data from different populations underscore our conclusion that there is currently no compelling link between inherited mtDNA variants and aging.
authors: Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
authors: Joanna
authors: J
authors: Collerton
authors: Deepthi
authors: D
authors: Ashok
authors: Carmen
authors: C
authors: Martin-Ruiz
authors: Angela
authors: A
authors: Pyle
authors: Gavin
authors: G
authors: Hudson
authors: Mohammad
authors: M
authors: Yadegarfar
authors: Karen
authors: K
authors: Davies
authors: Carol
authors: C
authors: Jagger
authors: Thomas
authors: T
authors: von Zglinicki
authors: Thomas B L
authors: TB
authors: Kirkwood
authors: Patrick F
authors: PF
authors: Chinnery
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D015331:Cohort Studies; D004272:DNA, Mitochondrial / Q000235:genetics*; D016330:Frail Elderly; D014644:Genetic Variation; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008136:Longevity / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial
keywords: Aging; Frailty; Genetics; Mitochondrial DNA
references: BMJ. 2009 Dec 22;339:b4904
references: 20028777
references: Mech Ageing Dev. 2011 Oct;132(10):496-502
references: 21864562
references: Lancet. 1998 Jan 17;351(9097):185-6
references: 9449878
references: Am J Hum Genet. 2000 Mar;66(3):1017-26
references: 10712215
references: J Gerontol A Biol Sci Med Sci. 2007 Jul;62(7):722-7
references: 17634318
references: J Gerontol A Biol Sci Med Sci. 2009 Oct;64(10):1049-57
references: 19567825
references: Exp Gerontol. 2011 Dec;46(12):987-93
references: 21945877
references: Am J Hum Genet. 2008 Aug;83(2):254-60
references: 18674747
references: Mech Ageing Dev. 2012 Jun;133(6):456-66
references: 22663935
references: Mol Biol Rep. 2012 Sep;39(9):9123-31
references: 22729909
references: Circulation. 2008 May 13;117(19):2492-501
references: 18458168
references: Eur J Hum Genet. 2004 Dec;12(12):1080-2
references: 15470367
references: Trends Genet. 2011 Oct;27(10):387-8
references: 21824675
references: FASEB J. 1999 Sep;13(12):1532-6
references: 10463944
references: J Med Genet. 2007 Jun;44(6):e80
references: 17551080
references: Hum Genet. 2003 Jan;112(1):29-33
references: 12483296
references: Nat Rev Genet. 2012 Dec;13(12):878-90
references: 23154810
references: Hum Genet. 2012 Feb;131(2):201-8
references: 21750925
references: Biogerontology. 2009 Aug;10(4):435-42
references: 18931934
references: Mech Ageing Dev. 2000 Jul 31;116(2-3):65-76
references: 10996007
references: Aging Cell. 2013 Apr;12(2):184-93
references: 23286790
references: Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1116-21
references: 12538859
references: Genetics. 1996 Dec;144(4):1835-50
references: 8978068
references: Exp Gerontol. 2001 Jul;36(7):1161-78
references: 11404057
references: Gerontology. 1998;44(6):349
references: 9813436
references: Eur J Hum Genet. 2005 Feb;13(2):166-70
references: 15483642