title: Increased liver apoptosis and tumor necrosis factor expression in Atlantic bluefin tuna (Thunnus thynnus) reared in the northern Adriatic Sea.
abstract: The Atlantic bluefin tuna Thunnus thynnus (ABFT) is intensely fished in the Mediterranean Sea to supply a prosperous capture-based mariculture industry. Liver apoptotic structures and tumor necrosis factor (TNF) gene expression were determined in: wild ABFT caught in the eastern Atlantic; juvenile ABFT reared in the central Adriatic Sea; juvenile ABFT reared in the northern Adriatic Sea; adult ABFT reared in the western Mediterranean. The highest density of liver apoptotic structures was found in the juveniles from the northern Adriatic. Two partial TNF cDNAs (TNF1 and TNF2) were cloned and sequenced. TNF1 gene expression was higher in juveniles than in adults. The highest expression of TNF2 was found in the juveniles from the northern Adriatic. These findings might be related to the juvenile exposure to environmental pollutants.
authors: Department of Emergency and Organ Transplant (D.E.T.O.), Section of Veterinary Clinics and Animal Production, University of Bari Aldo Moro, 70010 Valenzano, Bari, Italy.
authors: Aldo
authors: A
authors: Corriero
authors: Rosa
authors: R
authors: Zupa
authors: Chrysovalentinos
authors: C
authors: Pousis
authors: Nicoletta
authors: N
authors: Santamaria
authors: Giambattista
authors: G
authors: Bello
authors: Emilio
authors: E
authors: Jirillo
authors: Michele
authors: M
authors: Carrassi
authors: Carla
authors: C
authors: De Giorgi
authors: Letizia
authors: L
authors: Passantino
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004784:Environmental Monitoring / Q000379:methods*; D015870:Gene Expression; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008522:Mediterranean Sea; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism*; D014413:Tuna / Q000378:metabolism*; D014873:Water Pollutants / Q000633:toxicity; D014876:Water Pollution / Q000706:statistics & numerical data
chemical_list: D014409:Tumor Necrosis Factor-alpha; D014873:Water Pollutants