title: Pharmacodynamics modeling to optimize dosage regimens of sulbactam.
abstract: The aim of this study was to reveal population pharmacokinetics and assess the efficacies of various dosage regimens of sulbactam in terms of the probability of target attainment with this agent over a range of MICs. Monte Carlo simulations were performed to determine the probability of attaining specific pharmacodynamic targets. The results indicated that a regimen consisting of a 4-h infusion of 3 g of sulbactam every 8 h would be an alternative treatment option for less-susceptible pathogens.
authors: Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla, Thailand. jasutep@medicine.psu.ac.th
authors: Sutep
authors: S
authors: Jaruratanasirikul
authors: Wibul
authors: W
authors: Wongpoowarak
authors: Nanchanit
authors: N
authors: Aeinlang
authors: Monchana
authors: M
authors: Jullangkoon
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy*; D040981:Acinetobacter baumannii / Q000187:drug effects; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009010:Monte Carlo Method; D013407:Sulbactam / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D013407:Sulbactam
references: Clin Infect Dis. 2003 Jan 15;36(Suppl 1):S42-50
references: 12516029
references: Int J Antimicrob Agents. 2012 Nov;40(5):434-9
references: 22959555
references: Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):89-96
references: 7587056
references: Scand J Infect Dis. 2007;39(1):38-43
references: 17366011
references: Br J Pharmacol Chemother. 1965 Dec;25(3):638-50
references: 4958410
references: Infect Control Hosp Epidemiol. 2002 Aug;23(8):477-9
references: 12186218
references: Emerg Infect Dis. 2002 Aug;8(8):827-32
references: 12141969
references: Drug Dev Ind Pharm. 2002 Mar;28(3):345-51
references: 12026227
references: Antimicrob Agents Chemother. 1986 Aug;30(2):231-3
references: 3021050
references: Int J Antimicrob Agents. 1996 Apr;6 Suppl:S31-4
references: 18611717
references: Clin Infect Dis. 1997 Mar;24(3):494-7
references: 9114205
references: J Infect Dis. 1988 Oct;158(4):831-47
references: 3139779
references: J Antimicrob Chemother. 2001 Apr;47(4):479-82
references: 11266426
references: J Infect. 2008 Jun;56(6):432-6
references: 18501431