title: Vitamin D in chronic kidney disease.
abstract: Vitamin D deficiency is highly prevalent in patients with chronic kidney disease (CKD). The low vitamin D status is, to a large extent, caused by dysregulation of vitamin D metabolism as a result of renal insufficiency. Recent studies indicate that vitamin D-deficiency may promote or accelerate the progression of CKD, whereas treatment with low calcemic vitamin D analogs can reduce proteinuria and ameliorate renal damage in animal models of kidney disease and in patients with CKD. The renoprotective activity of vitamin D regulates multiple signaling pathways known to play important roles in renal injury. These findings underscore the importance of correcting vitamin D deficiency with vitamin D supplementation or with activated vitamin D analogs in the management of CKD.
authors: Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. cyan @ medicine.bsd.uchicago.edu
authors: Yan Chun
authors: YC
authors: Li
mesh_terms: D000818:Animals; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000378:metabolism; D018450:Disease Progression; D005786:Gene Expression Regulation; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D007249:Inflammation / Q000378:metabolism; D007668:Kidney / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000378:metabolism; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D050199:Podocytes / Q000378:metabolism; D015995:Prevalence; D011507:Proteinuria / Q000209:etiology / Q000517:prevention & control; D051381:Rats; D006435:Renal Dialysis / Q000009:adverse effects; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism* / Q000401:mortality / Q000517:prevention & control / Q000628:therapy; D012084:Renin-Angiotensin System / Q000502:physiology; D013250:Steroid Hydroxylases / Q000502:physiology; D014807:Vitamin D / Q000819:agonists / Q000502:physiology* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism*; D065668:Vitamin D3 24-Hydroxylase; D060449:Wnt Signaling Pathway
chemical_list: D016328:NF-kappa B; D014807:Vitamin D; D013250:Steroid Hydroxylases; D065668:Vitamin D3 24-Hydroxylase