title: Catalytic enantioselective carbon insertion into the β-vinyl C-H bond of cyclic enones.
abstract: Chiral oxazaborolidinium ion-catalyzed Csp(2)-H functionalization of enones using diazoacetate has been developed. Various β-substituted cyclic enones were synthesized in high yield (up to 99%) with high to excellent enantioselectivity (up to 99% ee). The synthetic utility of this reaction was demonstrated by the formal synthesis of (+)-epijuvabione.
authors: Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
authors: Sung Il
authors: SI
authors: Lee
authors: Geum-Sook
authors: GS
authors: Hwang
authors: Do Hyun
authors: DH
authors: Ryu