title: [Organization of eukaryotic chromosomes: from Kol'tsov's studies up to present day].
abstract: N. K. Kol'tsov ideas and views on the organization of eukaryotic chromosomes, including the notion of a giant hereditary molecule (genoneme) and its structural functional organization, are considered. Different approaches to chromosome studies are discussed, ranging from the examination of a chromosome as a stained cell organelle and the visualization of individual chromosomes in a living cell to the identification of topological domains of human and murine chromosomes using 3C and 5C technologies. The prospects of studies of chromosome organization using up-to-date methods of cytology, molecular biology, and bioinformatics are discussed.
authors: Institute of Cytology an Genetics, Siberian Branch of RAS, Novosibirsk, Russia
authors: N B
authors: NB
authors: Rubtsov
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000235:genetics* / Q000378:metabolism / Q000648:ultrastructure; D056890:Eukaryota / Q000235:genetics; D006801:Humans