title: Semi-IPN chitosan/polyvinylpyrrolidone microspheres and films: sustained release and property optimisation.
abstract: A set of chitosan-polyvinylpyrrolidone (CH-PVP) microspheres were prepared as semi-inter penetrating networks (semi-IPN) and loaded with 5-fluorouracil. In vitro release studies showed faster release for semi-IPN microspheres compared to pure CH samples, and the total release was achieved in about 20-30 days, depending on the composition. In vitro cell studies were achieved against human breast adenocarcinoma cell line cells where adsorption of cells on microspheres with a significant decrease in their number was obtained. Meanwhile, the CH-PVP films, which were prepared with the same compositions as in the microspheres, demonstrated an increase in strength from 66 to 118 MPa as the PVP content was decreased. It can be concluded that the prepared CH-PVP semi-IPN microspheres are novel promising carriers compared to pure CH microspheres since it becomes possible to adjust stability and hydrophilicity of the microspheres as well as the release rates of the drugs from the microspheres by changing the ratio of CH/PVP composition.
authors: Graduate Department of Polymer Science and Technology, Middle East Technical University , 06800 Ankara , Turkey .
authors: Taylan
authors: T
authors: Ozerkan
authors: Umran
authors: U
authors: Aydemir Sezer
authors: İsmet
authors: İ
authors: Deliloglu Gurhan
authors: Sultan
authors: S
authors: Gulce İz
authors: Nesrin
authors: N
authors: Hasirci
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy; D002460:Cell Line; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D008863:Microspheres; D011205:Povidone / Q000737:chemistry*
chemical_list: D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D048271:Chitosan; D011205:Povidone; D005472:Fluorouracil