title: Sensory neuron-derived eph regulates glomerular arbors and modulatory function of a central serotonergic neuron.
abstract: Olfactory sensory neurons connect to the antennal lobe of the fly to create the primary units for processing odor cues, the glomeruli. Unique amongst antennal-lobe neurons is an identified wide-field serotonergic neuron, the contralaterally-projecting, serotonin-immunoreactive deutocerebral neuron (CSDn). The CSDn spreads its termini all over the contralateral antennal lobe, suggesting a diffuse neuromodulatory role. A closer examination, however, reveals a restricted pattern of the CSDn arborization in some glomeruli. We show that sensory neuron-derived Eph interacts with Ephrin in the CSDn, to regulate these arborizations. Behavioural analysis of animals with altered Eph-ephrin signaling and with consequent arborization defects suggests that neuromodulation requires local glomerular-specific patterning of the CSDn termini. Our results show the importance of developmental regulation of terminal arborization of even the diffuse modulatory neurons to allow them to route sensory-inputs according to the behavioural contexts.
authors: National Centre for Biological Sciences, Tata Institute of Fundamental Research, GKVK Campus, Bangalore, India.
authors: Ajeet Pratap
authors: AP
authors: Singh
authors: Rudra Nayan
authors: RN
authors: Das
authors: Gururaj
authors: G
authors: Rao
authors: Aman
authors: A
authors: Aggarwal
authors: Soeren
authors: S
authors: Diegelmann
authors: Jan Felix
authors: JF
authors: Evers
authors: Hrishikesh
authors: H
authors: Karandikar
authors: Matthias
authors: M
authors: Landgraf
authors: Veronica
authors: V
authors: Rodrigues
authors: K
authors: K
authors: Vijayraghavan
mesh_terms: D000818:Animals; D009812:Odorants; D009833:Olfactory Pathways; D018034:Olfactory Receptor Neurons; D011984:Sensory Receptor Cells; D059326:Serotonergic Neurons; D012701:Serotonin
chemical_list: D012701:Serotonin
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