title: Association of periodontitis with carotid artery intima-media thickness and arterial stiffness in community-dwelling people in Japan: the Nagasaki Islands study.
abstract: OBJECTIVE
  Recent studies have suggested an association between periodontitis and atherosclerosis; however, the relationship between periodontal status and arterial alterations should be clarified. The purpose of this study was to examine associations between periodontal status and carotid intima-media thickness (cIMT) and arterial stiffness using the cardio-ankle vascular index (CAVI) in community dwellers.
  
  
  METHODS
  A community-based cross-sectional study of 1053 subjects ≥40 years with 10 teeth or more was conducted in Goto, Japan from 2008 to 2010.
  
  
  RESULTS
  In a multiple linear regression analysis adjusted for age, sex, number of present teeth, and other confounders, each 1-mm increase in mean periodontal pocket depth corresponded to a 0.02-mm increase in maximal cIMT (β = 0.018; P = 0.049) and also to a 0.1 increase in mean CAVI (β = 0.133; P = 0.040). In addition, each 1-mm increase in the mean periodontal attachment loss corresponded to a 0.01-mm increase in maximal cIMT (β = 0.013; P = 0.040). A multiple logistic regression analysis revealed that each 1-mm increase in mean periodontal pocket depth was associated with an increased risk of a maximal cIMT >1 mm (adjusted odds ratio [OR], 1.430; 95% confidence interval [CI], 1.067-1.918; P = 0.017) and mean CAVI of ≥8 (OR, 1.323; 95% CI, 1.003-1.743; P = 0.047). Furthermore, each 1-mm increase in mean periodontal attachment loss was associated with an increased risk of a maximal cIMT >1 mm (OR, 1.251; 95% CI, 1.032-1.516; P = 0.022).
  
  
  CONCLUSIONS
  A linear, dose-dependent relationship was found between periodontal pocket depth, cIMT, and arterial stiffness.
authors: Department of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, Japan. hide@nagasaki-u.ac.jp
authors: Hideaki
authors: H
authors: Hayashida
authors: Toshiyuki
authors: T
authors: Saito
authors: Koji
authors: K
authors: Kawasaki
authors: Masayasu
authors: M
authors: Kitamura
authors: Reiko
authors: R
authors: Furugen
authors: Takahiro
authors: T
authors: Iwasaki
authors: Yoshiko
authors: Y
authors: Hayashida
authors: Mio
authors: M
authors: Nakazato
authors: Takaharu
authors: T
authors: Sekita
authors: Noboru
authors: N
authors: Takamura
authors: Takahiro
authors: T
authors: Maeda
mesh_terms: D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000208:ethnology*; D059168:Carotid Intima-Media Thickness; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D062312:Islands / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D016014:Linear Models; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000208:ethnology*; D012111:Residence Characteristics
chemical_list: D008055:Lipids