title: Aceclofenac induced Stevens-Johnson/toxic epidermal necrolysis overlap syndrome.
abstract: The purpose of this paper is to report a rare occurrence of Stevens-Johnson/Toxic epidermal necrolysis (SJS/TEN) overlap syndrome after the use of aceclofenac. A 38 year old healthy adult male presented with rapidly evolving rash over face and upper body with ulceration of buccal mucosa and breathlessness after taking aceclofenac tablet. Naranjo score for this adverse drug event was six, thereby making it a probable adverse drug reaction. Despite aggressive fluid resuscitation and use of antihistamines and systemic steroids, patient's health rapidly worsened and died within six hours of presentation. Aceclofenac induced SJS/TEN overlap is an extremely rare clinical association previously reported only once in medical literature. To the best of our knowledge, this is the first case report of such an association in the Indian population. We are presenting this case to highlight the serious adverse reactions possible from a routinely prescribed drug.
authors: Department of General Medicine, Government Stanley Hospital, Chennai, Tamil Nadu, India.
authors: Kaderthambi Hajamohideen Nooru
authors: KH
authors: Ameen
authors: Rakesh
authors: R
authors: Pinninti
authors: Swathi
authors: S
authors: Jami
keywords: Corticosteroids; Stevens-Johnson syndrome; toxic epidermal necrolysis
references: Arch Dermatol. 1991 Jun;127(6):839-42
references: 2036029
references: J Am Acad Dermatol. 2008 Jan;58(1):33-40
references: 17919775
references: Arch Dermatol. 1993 Jan;129(1):92-6
references: 8420497
references: J Rheumatol. 2003 Oct;30(10):2234-40
references: 14528522
references: Ann Allergy Asthma Immunol. 2005 Apr;94(4):419-36; quiz 436-8, 456
references: 15875523
references: Arch Dermatol. 1987 Sep;123(9):1160-5
references: 3632000
references: Fundam Clin Pharmacol. 2013 Apr;27(2):223-30
references: 21929527
references: Dtsch Med Wochenschr. 2003 Mar 7;128(10):487-90
references: 12627339
references: Arch Dermatol. 2000 Mar;136(3):323-7
references: 10724193