title: [Genetic polymorphisms of four SNP loci in D5 gene of dopamine receptor in Northern Chinese Han population].
abstract: OBJECTIVE
  To reveal the genetic polymorphisms of four SNP loci (rs77434921, rs2076907, rs6283, rs1800762) in D5 gene of dopamine receptor (DRD5) in Northern Chinese Han population.
  
  
  METHODS
  Four SNP loci of the DRD5 gene of 206 unrelated individuals in Northern Chinese Han population were separately amplified and sequenced by PCR technique and statistically analyzed by Haploview v4.1 software.
  
  
  RESULTS
  In Northern Chinese Han population, the genotype frequency distribution of rs77434921, rs2076907, rs6283 and rs1800762 loci in the DRD5 gene were all in accordance with Hardy-Weinberg equilibrium. DP value was 0.145, 0.532, 0.602 and 0.159, while PE value was 0.004, 0.079, 0.196 and 0.007. A linkage disequilibrium among these four SNP loci was also demonstrated, which might infer five haplotypes.
  
  
  CONCLUSIONS
  rs2076907 and rs6283 loci of DRD5 gene in the Northern Chinese Han population have high genetic polymorphisms, which can be useful for forensic identification of individuals.
authors: School of Forensic Medicine, China Medical University, Shenyang 110001, China. qigemingdounanai@163.com
authors: Yi
authors: Y
authors: Zhao
authors: Mei
authors: M
authors: Ding
authors: Hao
authors: H
authors: Pang
authors: Jia-Xin
authors: JX
authors: Xing
authors: Jin-Feng
authors: JF
authors: Xuan
authors: Jun
authors: J
authors: Yao
authors: Yi-Hua
authors: YH
authors: Sun
authors: Bao-Jie
authors: BJ
authors: Wang
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D017931:DNA Primers / Q000235:genetics; D053803:Forensic Genetics; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D050641:Receptors, Dopamine D5 / Q000235:genetics*
chemical_list: D017931:DNA Primers; D005819:Genetic Markers; D050641:Receptors, Dopamine D5