title: A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles.
abstract: This report demonstrates a microfluidic origami chip to synthesize monodisperse, doxorubicin-loaded poly(lactic-co-glycolic acid) nanoparticles with diameters of ~100 nm, a size optimized for cellular uptake and anticancer efficacy, but difficult to achieve with existing approaches. This three-dimensional design in a microchannel may allow for the fabrication of polymeric nanoparticles in this size regime with ease.
authors: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China.
authors: Jiashu
authors: J
authors: Sun
authors: Yunlei
authors: Y
authors: Xianyu
authors: Mengmeng
authors: M
authors: Li
authors: Wenwen
authors: W
authors: Liu
authors: Lu
authors: L
authors: Zhang
authors: Dingbin
authors: D
authors: Liu
authors: Chao
authors: C
authors: Liu
authors: Guoqing
authors: G
authors: Hu
authors: Xingyu
authors: X
authors: Jiang
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004317:Doxorubicin