title: Opportunities for synthetic biology in antibiotics: expanding glycopeptide chemical diversity.
abstract: Synthetic biology offers a new path for the exploitation and improvement of natural products to address the growing crisis in antibiotic resistance. All antibiotics in clinical use are facing eventual obsolesce as a result of the evolution and dissemination of resistance mechanisms, yet there are few new drug leads forthcoming from the pharmaceutical sector. Natural products of microbial origin have proven over the past 70 years to be the wellspring of antimicrobial drugs. Harnessing synthetic biology thinking and strategies can provide new molecules and expand chemical diversity of known antibiotic scaffolds to provide much needed new drug leads. The glycopeptide antibiotics offer paradigmatic scaffolds suitable for such an approach. We review these strategies here using the glycopeptides as an example and demonstrate how synthetic biology can expand antibiotic chemical diversity to help address the growing resistance crisis.
authors: M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, L8S 4K1 Canada.
authors: Maulik N
authors: MN
authors: Thaker
authors: M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, L8S 4K1 Canada.
authors: Gerard D
authors: GD
authors: Wright
mesh_terms: D000900:Anti-Bacterial Agents; D055808:Drug Discovery; D004352:Drug Resistance, Microbial; D006020:Glycopeptides; D008967:Molecular Biology; D058615:Synthetic Biology
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides
keywords: antibiotic scaffold; glycopeptides; heterologous host; resistance; synthetic biology; tailoring enzymes
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