title: DNA repair variants, indoor tanning, and risk of melanoma.
abstract: Although ultraviolet radiation (UV) exposure from indoor tanning has been linked to an increased risk of melanoma, the role of DNA repair genes in this process is unknown. We evaluated the association of 92 single nucleotide polymorphisms (SNPs) in 20 DNA repair genes with the risk of melanoma and indoor tanning among 929 patients with melanoma and 817 controls from the Minnesota Skin Health Study. Significant associations with melanoma risk were identified for SNPs in ERCC4, ERCC6, RFC1, XPC, MGMT, and FBRSL1 genes; with a cutoff of P < 0.05. ERCC6 and FBRSL1 gene variants and haplotypes interacted with indoor tanning. However, none of the 92 SNPs tested met the correction criteria for multiple comparisons. This study, based on an a priori interest in investigating the role of DNA repair capacity using variants in base excision and nucleotide excision repair, identified several genes that may play a role in resolving UV-induced DNA damage.
authors: Division of Epidemiology and Biostatistics, University of New Mexico, Albuquerque, NM, USA.
authors: Salina M
authors: SM
authors: Torres
authors: Li
authors: L
authors: Luo
authors: Jenna
authors: J
authors: Lilyquist
authors: Christine A
authors: CA
authors: Stidley
authors: Kristina
authors: K
authors: Flores
authors: Kirsten A M
authors: KA
authors: White
authors: Esther
authors: E
authors: Erdei
authors: Melissa
authors: M
authors: Gonzales
authors: Susan
authors: S
authors: Paine
authors: Rachel I
authors: RI
authors: Vogel
authors: Deann
authors: D
authors: Lazovich
authors: Marianne
authors: M
authors: Berwick
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000235:genetics*; D055108:Sunbathing
keywords: DNA repair; artificial UV; gene-environment interaction; indoor tanning; melanoma; single nucleotide polymorphisms
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