title: Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation.
abstract: We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation.
authors: Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA.
authors: Sang-Min
authors: SM
authors: Lee
authors: De-Hao
authors: DH
authors: Tsai
authors: Vincent A
authors: VA
authors: Hackley
authors: Martin W
authors: MW
authors: Brechbiel
authors: Robert F
authors: RF
authors: Cook
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002945:Cisplatin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D010984:Platinum / Q000737:chemistry; D011839:Radiation, Ionizing; D008063:Thioctic Acid / Q000737:chemistry; D056928:X-Ray Absorption Spectroscopy
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D004337:Drug Carriers; D010984:Platinum; C006903:carbopol 940; D008063:Thioctic Acid; D006046:Gold; D002945:Cisplatin
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