title: Polymer-assisted structural modification on nucleosides and nucleotides.
abstract: Nucleosides and their analogues play important roles in biological research and clinical therapeutics. Polymer-assisted structural modifications of nucleosides and nucleotides enable parallel and rapid construction of nucleoside library. For some nucleosides, higher chemical selectivity and regioselectivity can be achieved using solid-phase synthesis when compared to classic solution-phase synthesis.
authors: Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, United States of America. Peng.Zhao@tufts.edu
authors: Peng
authors: P
authors: Zhao
authors: Lihe
authors: L
authors: Zhang
mesh_terms: D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques
chemical_list: D009705:Nucleosides; D009711:Nucleotides; D011108:Polymers