title: Directed ortho-lithiation of aminophosphazenes: an efficient route to the stereoselective synthesis of P-chiral compounds.
abstract: Ortho-directed lithiation of P,P-diphenylaminophosphazenes followed by electrophilic quench is described as an efficient process for synthesizing P-chiral ortho-functionalized derivatives in high yields and diastereoselectivities. The method allows the tunable preparation of structurally diverse enantiopure P-chiral compounds including phosphinic and phosphinothioic amides, phosphinic esters, phosphine oxides, and o-aminophosphines.
authors: Área de Química Orgánica, Universidad de Almería , Carretera de Sacramento s/n, 04120 Almería, Spain, and Departamento de Química Física y Analítica, Universidad de Oviedo , C/Julián Clavería 8, 33006 Oviedo, Spain.
authors: María
authors: M
authors: Casimiro
authors: Laura
authors: L
authors: Roces
authors: Santiago
authors: S
authors: García-Granda
authors: María José
authors: MJ
authors: Iglesias
authors: Fernando
authors: F
authors: López Ortiz