title: What can rheumatologists learn from translational cancer therapy?
abstract: It is well established that an intimate connection exists between inflammation and neoplasia. Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site-specific inflammation are known to increase the probability of the development of specific cancers. Molecular characterisation of these processes has revealed profound similarities in the specific molecules involved in persistence of inflammation and in both the primary induction of neoplastic processes and in specification of the preferred anatomic sites of metastatic spread. The therapeutic importance of these findings is underscored by the remarkable success in the treatment of autoimmune pathology using medications initially developed for use in oncology and this arena is one of considerable therapeutic promise for rheumatologists.
authors: Jonathan P
authors: JP
authors: Sherlock
authors: Andrew D
authors: AD
authors: Filer
authors: John D
authors: JD
authors: Isaacs
authors: Christopher D
authors: CD
authors: Buckley
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology*; D012219:Rheumatology; D057170:Translational Research, Biomedical
references: Lancet. 2012 Apr 28;379(9826):1602-12
references: 22440946
references: Cytokine. 2012 May;58(2):133-47
references: 22349527
references: Gastroenterology. 2012 Sep;143(3):550-563
references: 22796521
references: BMC Cancer. 2011 May 08;11:162
references: 21549007
references: Br J Pharmacol. 2008 Mar;153 Suppl 1:S241-6
references: 17965753
references: J Exp Med. 1999 Nov 15;190(10):1375-82
references: 10562313
references: Carcinogenesis. 2006 May;27(5):1068-73
references: 16407368
references: Am J Hematol. 2012 Nov;87(11):1037-45
references: 23090888
references: Rheumatology (Oxford). 2013 Jan;52(1):91-8
references: 23238979
references: Clin Cancer Res. 2004 Oct 1;10(19):6528-34
references: 15475440
references: Cell. 2004 Aug 6;118(3):285-96
references: 15294155
references: Ann Rheum Dis. 2006 May;65(5):617-22
references: 16249224
references: Nature. 2006 Jul 27;442(7101):461-5
references: 16688182
references: Curr Opin Urol. 2009 Sep;19(5):494-9
references: 19553820
references: J Exp Med. 2001 Mar 19;193(6):727-40
references: 11257139
references: Nat Rev Cancer. 2004 Nov;4(11):839-49
references: 15516957
references: Am J Pathol. 2002 Jan;160(1):123-30
references: 11786406
references: Nat Med. 2012 Jul 01;18(7):1069-76
references: 22772566
references: J Clin Oncol. 2005 Sep 1;23(25):5950-9
references: 16135466
references: J Clin Oncol. 2007 Oct 10;25(29):4542-9
references: 17925549
references: Curr Drug Targets. 2008 May;9(5):375-80
references: 18473765
references: Joint Bone Spine. 2010 Jul;77(4):372-3
references: 20478730
references: Science. 1985 Mar 8;227(4691):1231-3
references: 3975611
references: J Rheumatol. 2009 Jun;36(6):1118-25
references: 19447938
references: Expert Opin Biol Ther. 2012 Sep;12(9):1277-89
references: 22849354
references: Clin Rheumatol. 2003 Oct;22(4-5):329-32
references: 14576993
references: Oncology. 2013;84(1):43-56
references: 23128843
references: Ann Rheum Dis. 2010 Sep;69(9):1629-35
references: 20488885
references: J Biosci. 2012 Jul;37(3):503-17
references: 22750987
references: J Rheumatol. 2008 Aug;35(8):1682
references: 18671330
references: Genes Dev. 2006 Sep 15;20(18):2527-38
references: 16980582
references: Ann Oncol. 2008 Jul;19(7):1340-1346
references: 18325912
references: FASEB J. 2007 Aug;21(10):2359-67
references: 17440118
references: J Intern Med. 2000 Sep;248(3):171-83
references: 10971784
references: Cell Res. 2011 Jan;21(1):159-68
references: 21187858
references: Autoimmun Rev. 2010 Feb;9(4):203-6
references: 19602455
references: Science. 2010 Nov 5;330(6005):827-30
references: 21051638
references: Pharmacol Rev. 2012 Oct;64(4):1027-54
references: 23023033
references: Annu Rev Immunol. 2001;19:163-96
references: 11244034
references: Nat Med. 2007 Oct;13(10):1211-8
references: 17906636
references: Am J Hematol. 2012 Apr;87(4):401-11
references: 22410759
references: Arthritis Rheum. 2010 Dec;62(12):3595-606
references: 20722022
references: Gastroenterology. 1994 Aug;107(2):369-78
references: 8039614
references: Oncogene. 2007 May 28;26(25):3603-13
references: 17530014
references: Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10025-30
references: 12119414
references: Nature. 2001 Mar 1;410(6824):50-6
references: 11242036
references: Cancer Res. 2002 Jun 15;62(12):3395-401
references: 12067981
references: Immunol Rev. 2008 Apr;222:162-79
references: 18364001