title: Pathogen-induced autophagy signaling in innate immunity.
abstract: Innate immunity induces rapid responses to fight invading pathogens. To eliminate intracellular bacteria or viruses, innate cellular responses lead to the production of nuclear factor-κB-dependent inflammatory cytokines, inflammasome activation, type I interferon synthesis, and/or eventually death of the infected cells. Autophagy emerged as another component of innate immunity, as it offers an immediate autonomous cell defense mechanism by degrading intracellular pathogens. In addition, autophagy participates in the regulation of immune and inflammatory cell responses. Instead of providing a comprehensive status of the art that has already been addressed elsewhere, we chose to highlight some recent issues brought up in the field.
authors: International Center for Infectiology Research, Inserm U1111, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon 1, Lyon, France. mathias.faure@inserm.fr
authors: Mathias
authors: M
authors: Faure
authors: Frank
authors: F
authors: Lafont
mesh_terms: D000818:Animals; D001343:Autophagy / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D059748:Proteolysis; D015398:Signal Transduction
references: J Immunol. 2012 Oct 15;189(8):4144-53
references: 22972933
references: Cell. 2005 Sep 23;122(6):927-39
references: 16179260
references: Science. 2011 May 6;332(6030):717-21
references: 21551061
references: Ann Rheum Dis. 2013 Jun;72(6):1044-52
references: 23117241
references: Nature. 2008 Nov 13;456(7219):264-8
references: 18849965
references: PLoS Pathog. 2012;8(5):e1002689
references: 22589721
references: Nat Immunol. 2004 Oct;5(10):1052-60
references: 15334086
references: Cell Death Differ. 2013 Mar;20(3):515-23
references: 23175187
references: Mol Cell Biol. 2009 May;29(10):2594-608
references: 19289499
references: PLoS Pathog. 2009 Nov;5(11):e1000670
references: 19956673
references: PLoS Pathog. 2012 Feb;8(2):e1002517
references: 22319449
references: Mol Cell. 2012 Jul 13;47(1):111-21
references: 22633953
references: Trends Immunol. 2012 Oct;33(10):475-87
references: 22796170
references: Immunity. 2012 Jun 29;36(6):933-46
references: 22749352
references: Cell Cycle. 2012 Jan 1;11(1):194-9
references: 22186785
references: Sci Signal. 2010 May 25;3(123):ra42
references: 20501938
references: PLoS One. 2012;7(6):e40069
references: 22768222
references: Arch Biochem Biophys. 2011 Feb 15;506(2):223-35
references: 21156154
references: PLoS One. 2012;7(6):e38899
references: 22745684
references: Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14050-5
references: 17709747
references: Immunity. 2000 May;12(5):581-90
references: 10843390
references: J Exp Med. 2010 Aug 2;207(8):1745-55
references: 20603313
references: Cell Res. 2006 Nov;16(11):895-901
references: 17088896
references: Cell. 2010 May 14;141(4):656-67
references: 20478256
references: Sci Signal. 2009 Aug 18;2(84):ra47
references: 19690333
references: J Biol Chem. 2011 Mar 18;286(11):9587-97
references: 21228274
references: Oncogene. 2010 Sep 23;29(38):5299-310
references: 20622903
references: Mol Biol Cell. 2010 Mar 15;21(6):1001-10
references: 20089838
references: Immunity. 2012 Jun 29;36(6):947-58
references: 22658522
references: Autophagy. 2011 Mar;7(3):321-30
references: 21217200
references: Nat Immunol. 2011 Mar;12(3):222-30
references: 21151103
references: PLoS Pathog. 2012;8(6):e1002743
references: 22719249
references: Biochim Biophys Acta. 2009 Dec;1793(12):1901-16
references: 19781582
references: J Immunol. 2011 Jan 15;186(2):1248-58
references: 21160040
references: Cell Host Microbe. 2009 Aug 20;6(2):137-49
references: 19683680
references: Oncogene. 2011 Apr 7;30(14):1727-32
references: 21151171
references: Cancer Cell. 2008 Apr;13(4):343-54
references: 18394557
references: Autophagy. 2011 Jan;7(1):17-26
references: 20980813
references: Gastroenterology. 2011 Aug;141(2):674-85, 685.e1-6
references: 21683701
references: Curr Opin Immunol. 2012 Feb;24(1):21-31
references: 22118953
references: Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20842-6
references: 19926846
references: Mol Cell Biol. 2012 May;32(9):1733-44
references: 22354992
references: Science. 2007 Mar 9;315(5817):1398-401
references: 17272685
references: Nature. 2011 Jan 6;469(7328):107-11
references: 21170023
references: Mediators Inflamm. 2008;2008:725854
references: 18566685
references: Cell. 2009 Jun 12;137(6):1001-4
references: 19524504
references: Cell Host Microbe. 2012 Sep 13;12(3):381-9
references: 22980334
references: PLoS Pathog. 2009 May;5(5):e1000430
references: 19436699
references: Nat Cell Biol. 2010 Aug;12(8):747-57
references: 20639872
references: Cell Signal. 2012 Jun;24(6):1150-62
references: 22333395
references: Cell. 2011 Jul 22;146(2):303-17
references: 21784250
references: Cell Microbiol. 2012 Aug;14(8):1149-65
references: 22452336
references: J Clin Invest. 2011 Jan;121(1):37-56
references: 21135505
references: J Innate Immun. 2013;5(5):434-43
references: 23328432
references: J Cell Sci. 2012 Mar 1;125(Pt 5):1141-51
references: 22302993
references: PLoS Pathog. 2007 Aug 10;3(8):e111
references: 17696608
references: Cell Host Microbe. 2012 Sep 13;12(3):334-45
references: 22980330
references: Virology. 2010 Sep 30;405(2):383-9
references: 20605567
references: Immunity. 2012 Aug 24;37(2):223-34
references: 22921120
references: Annu Rev Immunol. 2012;30:611-46
references: 22449030
references: Science. 2011 Jul 8;333(6039):228-33
references: 21617041
references: Nature. 2012 Mar 11;483(7391):623-6
references: 22407319
references: J Cell Biol. 2011 Dec 12;195(6):931-42
references: 22123830
references: J Innate Immun. 2013;5(5):471-9
references: 23445716
references: Mol Cell. 2010 May 28;38(4):524-38
references: 20513428
references: Nature. 2012 Jan 15;482(7385):414-8
references: 22246324
references: Hum Mol Genet. 2008 Jan 15;17(2):170-8
references: 17921520
references: PLoS Pathog. 2012;8(8):e1002844
references: 22876183
references: Nat Immunol. 2008 Aug;9(8):908-16
references: 18604211
references: Gastroenterology. 2010 Nov;139(5):1630-41, 1641.e1-2
references: 20637199
references: Immunity. 2010 May 28;32(5):654-69
references: 20451412
references: Autophagy. 2006 Jan-Mar;2(1):24-9
references: 16874088
references: J Immunol. 2011 Nov 15;187(10):5268-76
references: 21998456
references: Genes Dev. 2011 Jul 15;25(14):1510-27
references: 21764854
references: Cell Microbiol. 2011 Sep;13(9):1429-39
references: 21740499
references: Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3168-76
references: 23093667
references: PLoS Pathog. 2012 Feb;8(2):e1002507
references: 22319448
references: J Biol Chem. 2012 Feb 3;287(6):4323-34
references: 22170068
references: Cell. 2012 Aug 17;150(4):803-15
references: 22901810
references: Protein Cell. 2012 Aug;3(8):581-9
references: 22865346
references: Mol Cell. 2012 Nov 9;48(3):329-42
references: 23022382
references: Autophagy. 2007 Jan-Feb;3(1):21-5
references: 17172799
references: Eur J Immunol. 2013 Jan;43(1):147-58
references: 22996354
references: J Biol Chem. 2012 Jul 20;287(30):25565-76
references: 22665475
references: Cancer Res. 2012 Jun 15;72(12):2970-9
references: 22505650
references: J Immunol. 2012 Jul 1;189(1):15-20
references: 22723639
references: Cell. 2011 Jul 22;146(2):290-302
references: 21784249
references: EMBO J. 2008 Apr 9;27(7):1110-21
references: 18337753
references: Cell. 2012 Dec 7;151(6):1256-69
references: 23217709
references: Cell Microbiol. 2013 Mar;15(3):368-76
references: 23051682
references: J Biol Chem. 2011 Jul 1;286(26):22886-93
references: 21454695
references: Cell Microbiol. 2010 Aug;12(8):1046-63
references: 20148899
references: EMBO J. 2011 Nov 11;30(24):4908-20
references: 22081109
references: Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2770-5
references: 19196953
references: J Infect Dis. 2012 Apr 15;205(8):1258-67
references: 22396599
references: Biol Cell. 2010 Dec;102(12):621-34
references: 21077843
references: Immunol Rev. 2011 Mar;240(1):92-104
references: 21349088
references: Immunity. 2007 Jul;27(1):135-44
references: 17658277
references: Curr Biol. 2012 Jul 10;22(13):R540-5
references: 22790007
references: Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3502-7
references: 17360673
references: J Biol Chem. 2012 Oct 5;287(41):34683-93
references: 22891252
references: J Cell Biol. 2012 May 28;197(5):659-75
references: 22613832
references: Cell. 2009 Jun 12;137(6):1062-75
references: 19524509
references: J Cell Biol. 2010 Sep 6;190(5):881-92
references: 20819940
references: PLoS Pathog. 2011 Dec;7(12):e1002422
references: 22174682
references: Cell Host Microbe. 2009 Oct 22;6(4):354-66
references: 19837375
references: Traffic. 2010 Sep;11(9):1246-61
references: 20545908
references: Cell. 2012 Aug 31;150(5):1029-41
references: 22939626
references: J Biol Chem. 2010 Jul 16;285(29):22666-75
references: 20472552
references: Cell Signal. 2010 Nov;22(11):1645-54
references: 20600852
references: Cell. 2011 Jan 21;144(2):253-67
references: 21241894
references: Immunity. 2010 Mar 26;32(3):329-41
references: 20206555
references: Cell Host Microbe. 2012 Jun 14;11(6):563-75
references: 22704617
references: EMBO J. 2010 Feb 3;29(3):619-31
references: 19959994
references: Oncogene. 2007 Jun 14;26(28):4071-83
references: 17213804
references: Nat Immunol. 2010 Jan;11(1):55-62
references: 19898471
references: Science. 2012 Nov 23;338(6110):1072-6
references: 23112293
references: Cell Host Microbe. 2012 May 17;11(5):457-68
references: 22607799
references: J Immunol. 2011 Oct 15;187(8):3953-61
references: 21911604
references: Cell Res. 2007 Jun;17(6):520-30
references: 17563756
references: J Cell Biol. 2012 Feb 20;196(4):483-96
references: 22351926
references: Nat Immunol. 2012 May;13(5):449-56
references: 22484733
references: Autophagy. 2013 Mar;9(3):317-27
references: 23242206
references: J Immunol. 2011 Feb 1;186(3):1646-55
references: 21209283
references: Cancer Res. 2012 Jun 1;72(11):2791-801
references: 22472122
references: Nat Immunol. 2012 Jan 29;13(3):255-63
references: 22286270
references: Nature. 2011 Dec 1;480(7375):113-7
references: 22020285
references: Nature. 2011 Jan 13;469(7329):221-5
references: 21124315
references: Cell Host Microbe. 2009 Feb 19;5(2):123-36
references: 19218084
references: EMBO J. 2011 Nov 08;30(23):4701-11
references: 22068051
references: Autophagy. 2013 Mar;9(3):287-302
references: 23221969
references: J Biol Chem. 2006 Oct 13;281(41):30373-82
references: 16857678