title: Plasma fatty acid lipidomics in amnestic mild cognitive impairment and Alzheimer's disease.
abstract: Polyunsaturated fatty acids (PUFA) of the n-3 series have been linked to brain physiology and cognitive decline, but little is known about the other components of the complex fatty acids category. Here, we compared 30 molecular species pertaining to saturated, monounsaturated, polyunsaturated, and trans fatty acids, measured in plasma by gas chromatography, in 14 patients with a diagnosis of amnestic single domain mild cognitive impairment (aMCI), 30 patients with mild Alzheimer's disease (AD), and 30 healthy controls (HC). As no participants showed neuroimaging evidence of cerebrovascular disease, patients could be considered as purely neurodegenerative. We found differences in specific components of almost all fatty acid classes except n-3-polyunsaturated fatty acids. Compared with HC, aMCI and AD patients had higher levels of arachidic (C20:0), erucic (C22:1, n-9), and vaccenic acid (C18:1, n-9) and lower levels of cerotic (C26:0) and linoleic acid (C18:2, n-6). In particular, level of linoleic acid decreased and level of mead acid increased progressively from HC to aMCI to AD patients, and they were also inversely correlated in AD and aMCI patients. In conclusion, we found a previously unrecognized linoleic acid deficiency in the early phase of neurodegeneration that was strongly supported by an increased, compensatory mead acid level. These findings suggest the importance of creating new dietary manipulation strategies to counteract disease progression.
authors: Department of Medico-Surgical Sciences and Biotechnology, Vascular Biology and Mass Spectrometry Laboratory, Sapienza University of Rome, Latina, Italy.
authors: Luigi
authors: L
authors: Iuliano
authors: Antonio
authors: A
authors: Pacelli
authors: Marco
authors: M
authors: Ciacciarelli
authors: Chiara
authors: C
authors: Zerbinati
authors: Sabrina
authors: S
authors: Fagioli
authors: Fabrizio
authors: F
authors: Piras
authors: Maria Donata
authors: MD
authors: Orfei
authors: Paola
authors: P
authors: Bossù
authors: Floriana
authors: F
authors: Pazzelli
authors: Gaetano
authors: G
authors: Serviddio
authors: Carlo
authors: C
authors: Caltagirone
authors: Gianfranco
authors: G
authors: Spalletta
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000175:diagnosis*; D000647:Amnesia / Q000097:blood*; D060825:Cognitive Dysfunction / Q000097:blood*; D018450:Disease Progression; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D005227:Fatty Acids