title: Family history of idiopathic REM behavior disorder: a multicenter case-control study.
abstract: OBJECTIVE
  To compare the frequency of proxy-reported REM sleep behavior disorder (RBD) among relatives of patients with polysomnogram-diagnosed idiopathic RBD (iRBD) in comparison to controls using a large multicenter clinic-based cohort.
  
  
  METHODS
  A total of 316 patients with polysomnography-confirmed iRBD were recruited from 12 RBD study group centers, along with 316 controls matched on sex and age group. All subjects completed a self-administered questionnaire that collected proxy-reported information on family history of tremor, gait trouble, balance trouble, Parkinson disease, memory loss, and Alzheimer disease. The questionnaire also included a single question that asked about possible symptoms of RBD among first-degree relatives (siblings, parents, and children).
  
  
  RESULTS
  A positive family history of dream enactment was reported in 13.8% of iRBD cases compared to 4.8% of controls (odds ratio [OR] = 3.9, 95% confidence interval [CI] 2.0-7.7). ORs were increased for both siblings (OR = 6.1, 95% CI 2.1-18.1) and parents (OR = 3.2, 95% CI 1.4-7.8). We found no significant difference in sex, current age (65.3 ± 10.2 vs 66.9 ± 10.2 years), or age at self-reported RBD onset (55.2 ± 11.7 vs 56.6 ± 15.1 years) in possible familial vs sporadic iRBD. No differences were found in family history of tremor, walking and balance troubles, Parkinson disease, memory loss, or Alzheimer disease.
  
  
  CONCLUSIONS
  We found increased odds of proxy-reported family history of presumed RBD among individuals with confirmed iRBD. This suggests the possibility of a genetic contribution to RBD.
authors: Department of Neurology, Hôpital Gui de Chauliac, INSERM U1061, Montpellier, France. ydauvilliers@yahoo.fr
authors: Yves
authors: Y
authors: Dauvilliers
authors: Ronald B
authors: RB
authors: Postuma
authors: Luigi
authors: L
authors: Ferini-Strambi
authors: Isabelle
authors: I
authors: Arnulf
authors: Birgit
authors: B
authors: Högl
authors: Raffaele
authors: R
authors: Manni
authors: Tomoyuki
authors: T
authors: Miyamoto
authors: Wolfgang
authors: W
authors: Oertel
authors: Maria Livia
authors: ML
authors: Fantini
authors: Monica
authors: M
authors: Puligheddu
authors: Poul
authors: P
authors: Jennum
authors: Karel
authors: K
authors: Sonka
authors: Marco
authors: M
authors: Zucconi
authors: Smeranda
authors: S
authors: Leu-Semenescu
authors: Birgit
authors: B
authors: Frauscher
authors: Michele
authors: M
authors: Terzaghi
authors: Masayuki
authors: M
authors: Miyamoto
authors: Marcus
authors: M
authors: Unger
authors: Alex
authors: A
authors: Desautels
authors: Christina
authors: C
authors: Wolfson
authors: Amélie
authors: A
authors: Pelletier
authors: Jacques
authors: J
authors: Montplaisir
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000379:methods; D020187:REM Sleep Behavior Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*
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