title: Long-term cardiac changes in patients with systemic lupus erythematosus.
abstract: BACKGROUND
  The aim of this study was evaluate the late-onset repercussions of heart alterations of patients with systemic lupus erythematosus (SLE) after a 13-year follow up.
  
  
  METHODS
  A historical prospective study was carried out involving the analysis of data from the charts of patients with a confirmed diagnosis of lupus in follow up since 1998. The 13-year evolution was systematically reviewed and tabulated to facilitate the interpretation of the data.
  
  
  RESULTS
  Forty-eight patient charts were analyzed. Mean patient age was 34.5 ± 10.8 years at the time of diagnosis and 41.0 ± 10.3 years at the time of the study (45 women and 3 men). Eight deaths occurred in the follow-up period (two due to heart problems). Among the alterations found on the complementary exams, 46.2% of cases demonstrated worsening at reevaluation and four patients required a heart catheterization. In these cases, coronary angioplasty was performed due to the severity of the obstructions and one case required a further catheterization, culminating in the need for surgical myocardial revascularization.
  
  
  CONCLUSIONS
  The analysis demonstrated progressive heart impairment, with high rates of alterations on conventional complementary exams, including the need for angioplasty or revascularization surgery in four patients. These findings indicate the need for rigorous cardiac follow up in patients with systemic lupus erythematosus.
authors: Departamento de Cardiologia e Cirurgia Cardiovascular, Faculdade de Medicina de São José do Rio Preto, Av, Brigadeiro Faria Lima, 5416, São José do Rio Preto, SP 15090-000, Brazil. mf60204@gmail.com
authors: Moacir Fernandes
authors: MF
authors: de Godoy
authors: Cibele Matsuura
authors: CM
authors: de Oliveira
authors: Vanessa Alves
authors: VA
authors: Fabri
authors: Luiz Carlos
authors: LC
authors: de Abreu
authors: Vitor E
authors: VE
authors: Valenti
authors: Adilson Casemiro
authors: AC
authors: Pires
authors: Rodrigo Daminello
authors: RD
authors: Raimundo
authors: José Luiz
authors: JL
authors: Figueiredo
authors: Glauce Rejane Leonardi
authors: GR
authors: Bertazzi
mesh_terms: D000328:Adult; D004452:Echocardiography; D004562:Electrocardiography; D005080:Exercise Test; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008875:Middle Aged
references: Int J Cardiol. 1990 Jun;27(3):367-75
references: 2351496
references: J Rheumatol. 1994 Nov;21(11):2147-56
references: 7869326
references: Clin Rev Allergy Immunol. 2013 Feb;44(1):1-5
references: 23054981
references: Am Heart J. 1985 Dec;110(6):1257-65
references: 3907317
references: Medicine (Baltimore). 1989 May;68(3):141-50
references: 2785628
references: J Rheumatol. 1984 Oct;11(5):588-90
references: 6239922
references: Arq Bras Cardiol. 1994 Jun;62(6):407-12
references: 7826232
references: N Engl J Med. 1988 Sep 29;319(13):817-23
references: 3412413
references: N Engl J Med. 1996 Nov 7;335(19):1424-30
references: 8875919
references: Int J Cardiol. 1992 Jan;34(1):69-74
references: 1548111
references: Angiology. 1985 Jul;36(7):431-41
references: 4025948
references: Am J Epidemiol. 2012 Oct 15;176(8):708-19
references: 23024137
references: Arthritis Rheum. 1982 Nov;25(11):1271-7
references: 7138600
references: Circulation. 1990 Aug;82(2):369-75
references: 2372888
references: Am J Epidemiol. 1997 Mar 1;145(5):408-15
references: 9048514
references: Ann Rheum Dis. 1992 Feb;51(2):156-9
references: 1550395
references: Acta Pathol Jpn. 1987 Jan;37(1):1-9
references: 3577764
references: J Rheumatol. 1995 Jul;22(7):1259-64
references: 7562755
references: Am J Med. 1975 Feb;58(2):243-64
references: 1115070
references: Rev Med Chir Soc Med Nat Iasi. 2012 Jan-Mar;116(1):83-9
references: 23077877
references: Cardiology. 1994;85(2):129-36
references: 7954564
references: Am J Med. 1976 Feb;60(2):221-5
references: 1251849
references: Arq Bras Cardiol. 1997 Feb;68(2):79-83
references: 9433831
references: Lupus. 2000;9(3):170-5
references: 10805483
references: Am J Med. 1981 Apr;70(4):775-81
references: 7211914
references: ISRN Rheumatol. 2012;2012:463620
references: 23119182
references: Medicine (Baltimore). 1992 Jul;71(4):216-23
references: 1518395
references: Am Heart J. 1987 Apr;113(4):966-71
references: 3565246