title: GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis.
abstract: OBJECTIVE
  The present study was undertaken to replicate the association of candidate genes for anti-TNF response in rheumatoid arthritis. Candidate genes were selected from a recent genome-wide association study on anti-TNF response performed in a population from Denmark.
  
  
  METHODS
  Genomic DNA was obtained from 315 Spanish rheumatoid arthritis patients having received an anti-TNF agent as their first biological therapy. SNPs from NR2FR2, MAP2K6, CBLN2 and PDE3A-SLCO1C1 candidate loci were genotyped.
  
  
  RESULTS
  The PDE3A-SLCO1C1 locus rs3794271 SNP showed a highly significant association with anti-TNF treatment response (p = 1.74 × 10⁻⁵). Combining the statistical evidence from the Spanish and Danish rheumatoid arthritis cohorts, the associated rs3794271 SNP reached a genome-wide significance level of association (p = 3.3 × 10⁻¹⁰).
  
  
  CONCLUSIONS
  The present findings establish the PDE3A-SLCO1C1 locus as a strong genetic marker of anti-TNF therapy response.
authors: Vall d'Hebron Hospital Research Institute, Rheumatology Research Group, Pg Vall Hebron 119-129, 08035 Barcelona, Spain.
authors: Isabel
authors: I
authors: Acosta-Colman
authors: Núria
authors: N
authors: Palau
authors: Jesús
authors: J
authors: Tornero
authors: Antonio
authors: A
authors: Fernández-Nebro
authors: Francisco
authors: F
authors: Blanco
authors: Isidoro
authors: I
authors: González-Alvaro
authors: Juan D
authors: JD
authors: Cañete
authors: Joan
authors: J
authors: Maymó
authors: Javier
authors: J
authors: Ballina
authors: Benjamín
authors: B
authors: Fernández-Gutiérrez
authors: Alex
authors: A
authors: Olivé
authors: Héctor
authors: H
authors: Corominas
authors: Alba
authors: A
authors: Erra
authors: Oriol
authors: O
authors: Canela-Xandri
authors: Arnald
authors: A
authors: Alonso
authors: Maria
authors: M
authors: López Lasanta
authors: Raül
authors: R
authors: Tortosa
authors: Antonio
authors: A
authors: Julià
authors: Sara
authors: S
authors: Marsal
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000235:genetics*; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3 / Q000235:genetics*; D003718:Denmark; D005260:Female; D056426:Genetic Loci; D005819:Genetic Markers / Q000235:genetics; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D027361:Organic Anion Transporters / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D018501:Antirheumatic Agents; D005819:Genetic Markers; D027361:Organic Anion Transporters; C473187:SLCO1C1 protein, human; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3; C517287:PDE3A protein, human