title: The household contact study design for genetic epidemiological studies of infectious diseases.
abstract: MOST GENETIC EPIDEMIOLOGICAL STUDY DESIGNS FALL INTO ONE OF TWO CATEGORIES: family based and population-based (case-control). However, recent advances in statistical genetics call for study designs that combine these two approaches. We describe the household contact study design as we have applied it in our several years of study of the epidemiology of tuberculosis. Though we highlight its applicability for genetic epidemiological studies of infectious diseases, there are many facets of this design that are appealing for modern genetic studies, including the simultaneous enrollment of related and unrelated individuals, closely and distantly related individuals, collection of extensive epidemiologic and phenotypic data, and evaluation of effects of shared environment and gene by environment interaction. These study design characteristics are particularly appealing for current sequencing studies.
authors: Department of Epidemiology and Biostatistics, Case Western Reserve University Cleveland, OH, USA ; Uganda - Case Western Reserve University Research Collaboration Kampala, Uganda.
authors: Catherine M
authors: CM
authors: Stein
authors: Noémi B
authors: NB
authors: Hall
authors: Lashaunda L
authors: LL
authors: Malone
authors: Ezekiel
authors: E
authors: Mupere
keywords: case-contact; cohort study; extended pedigrees; genetic association; whole genome studies
references: Genet Epidemiol. 2008 Sep;32(6):520-7
references: 18348203
references: Int J Tuberc Lung Dis. 2012 Aug;16(8):1033-9
references: 22692027
references: J Infect Dis. 2003 Jun 1;187(11):1679-85
references: 12751024
references: Ann N Y Acad Sci. 2010 Dec;1214:18-33
references: 21091717
references: Hum Hered. 2005;60(2):109-18
references: 16224188
references: Am Rev Respir Dis. 1982 Mar;125(3 Pt 2):8-15
references: 7073104
references: Hum Hered. 2010;70(4):278-86
references: 21212683
references: BMC Proc. 2011 Nov 29;5 Suppl 9:S76
references: 22373213
references: Hum Genomics. 2009 Oct;4(1):2-20
references: 19951892
references: Am J Epidemiol. 2003 Nov 1;158(9):887-98
references: 14585767
references: Lancet Infect Dis. 2010 Oct;10(10):723-32
references: 20883968
references: PLoS One. 2008;3(12):e4094
references: 19116662
references: Tuberculosis (Edinb). 2010 Mar;90(2):71-83
references: 20206579
references: Am J Public Health Nations Health. 1940 Jul;30(7):816-23
references: 18015266
references: PLoS Pathog. 2008 Mar 28;4(3):e1000034
references: 18369480
references: Biometrics. 2010 Dec;66(4):1024-33
references: 20163402
references: BMC Public Health. 2012 Dec 05;12:1050
references: 23217171
references: Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12183-8
references: 16103355
references: Clin Genet. 2009 Feb;75(2):101-6
references: 18783406
references: Bull World Health Organ. 2003;81(11):799-805
references: 14758406
references: Hum Genet. 2012 Oct;131(10):1555-63
references: 22714655
references: J Infect Dis. 2012 Dec 15;206(12):1809-15
references: 23033147
references: Am Rev Tuberc. 1952 Feb;65(2):111-27
references: 14885714
references: Am J Hum Genet. 2010 Apr 9;86(4):573-80
references: 20346434
references: Hum Immunol. 2011 May;72(5):426-30
references: 21354459
references: Am J Epidemiol. 2002 Jun 1;155(11):1074-9
references: 12034587
references: Am J Respir Crit Care Med. 2003 Aug 15;168(4):448-55
references: 12773322
references: Am J Epidemiol. 2012 Jul 1;176(1):70-9
references: 22573432
references: Hum Hered. 2007;64(2):91-6
references: 17476108
references: PLoS Pathog. 2011 Jan 20;7(1):e1001189
references: 21283783
references: Am J Trop Med Hyg. 2012 Apr;86(4):690-7
references: 22492155
references: Ann Epidemiol. 2012 Jul;22(7):466-73
references: 22575813
references: Nat Rev Genet. 2010 Jun;11(6):415-25
references: 20479773
references: Am J Trop Med Hyg. 2006 Jul;75(1):55-61
references: 16837709
references: Hum Genet. 2012 Oct;131(10):1525-31
references: 22898893
references: Am J Trop Med Hyg. 2013 Jul;89(1):169-73
references: 23629934
references: Hum Genet. 2007 Jul;121(6):663-73
references: 17431682