title: Use of glass ionomer cement containing antibiotics to seal off infected dentin: a randomized clinical trial.
abstract: Dental materials with antibacterial properties can prevent the harmful effects caused by oral cariogenic bacteria. This double-blind controlled clinical trial evaluated the performance of a glass ionomer cement (GIC) added with antibiotics for sealing infected dentin in atraumatic restorations of primary molars. The study enrolled 45 children (45 teeth) between 5 and 8 years of age, of both genders, divided into two groups: GC (n=22), where cavities were lined with a conventional GIC (Vidrion F) and GA (n=23), with cavities lined with Vidrion F added with 1% each of metronidazole, ciprofloxacin and cefaclor antibiotic. Both groups were restored with Ketac Molar Easymix. Molars with carious lesions on the inner half of dentin without clinical or radiographic pulp damage were selected. Patients were evaluated clinically (pain, fistulas or mobility) and radiographically (area of caries, periapical region and furcation) after 1, 3, 6 and 12 months. For statistical analysis, chi-squared or Fisher's exact tests were used with a 5% significance level. GA (82.6-95.7%) had better results than GC (12.5-36.4%) in all evaluations (p<0.05) and the difference in the success rate was 46.2-72.5% higher for GA. The use of the antibiotic-containing GIC liner on infected dentin proved satisfactory when applied in deciduous teeth.
authors: Graduate Program in Dentistry, Dental School, University of Pernambuco, Recife, PE, Brazil. jainara.s@ig.com.br
authors: Jainara Maria Soares
authors: JM
authors: Ferreira
authors: Sérgio Luiz
authors: SL
authors: Pinheiro
authors: Fábio Correia
authors: FC
authors: Sampaio
authors: Valdenice Aparecida de
authors: VA
authors: Menezes
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002327:Cariostatic Agents / Q000737:chemistry* / Q000627:therapeutic use; D002433:Cefaclor / Q000008:administration & dosage; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002939:Ciprofloxacin / Q000008:administration & dosage; D057087:Dental Atraumatic Restorative Treatment / Q000379:methods*; D003731:Dental Caries / Q000628:therapy*; D003736:Dental Cavity Lining; D003804:Dentin / Q000382:microbiology / Q000473:pathology*; D004311:Double-Blind Method; D005260:Female; D005899:Glass Ionomer Cements / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D014094:Tooth, Deciduous
chemical_list: D000900:Anti-Bacterial Agents; D002327:Cariostatic Agents; D005899:Glass Ionomer Cements; C090880:Vidrion F; D008795:Metronidazole; D002939:Ciprofloxacin; D002433:Cefaclor