title: Influence of prostaglandin analogue on outcome after combined cataract surgery and trabecular aspiration in pseudoexfoliative glaucoma.
abstract: OBJECTIVE
  The aim of this study was to analyze the postoperative outcome and risk profile after combined clear cornea phacoemulsification and trabecular aspiration in the treatment of pseudoexfoliative glaucoma (PEX) associated with cataract.
  
  
  METHODS
  In this retrospective study, 69 eyes of 60 patients with visually significant cataract and PEX were treated with small-incision cataract surgery combined with trabecular aspiration. The intraocular pressure (IOP), number of antiglaucoma eyedrops before and after surgery, as well as complications were measured at all postoperative visits (1 day, 7 days, 6 weeks, 6 months, 12 months).
  
  
  RESULTS
  There was a statistically significant decrease in postoperative IOP during the follow-up  period. There was no significant difference in the number of medications being used after 6 weeks follow-up. Six months and 12 months after surgery, the number of antiglaucoma eyedrops decreased significantly. Complications were fibrinotic iritis in 4 eyes (5.9%), cystoid macular edema in 3 eyes (4.4%), and hyphema in 1 eye (1.4%). Fibrinotic iritis and macular edema were present in only 37 of  69 eyes that were treated with prostaglandin analogues.
  
  
  CONCLUSIONS
  Small-incision cataract surgery combined with trabecular aspiration in cases of PEX associated with cataract is effective in IOP reduction over a 1-year follow-up. Prostaglandin analogues may increase the risk of postoperative macular edema and fibrinotic iritis. Preoperative medication exchange may be considered.
authors: Department of Ophthalmology, Charité, University Medicine Berlin, Berlin - Germany. johannes.gonnermann@charite.de
authors: Johannes
authors: J
authors: Gonnermann
authors: Matthias K J
authors: MK
authors: Klamann
authors: Anna-Karina B
authors: AK
authors: Maier
authors: Necip
authors: N
authors: Torun
authors: Peter C
authors: PC
authors: Ruokonen
authors: Eckart
authors: E
authors: Bertelmann
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017889:Exfoliation Syndrome / Q000601:surgery*; D005260:Female; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D019654:Lens Implantation, Intraocular; D008297:Male; D009883:Ophthalmic Solutions; D018918:Phacoemulsification; D011184:Postoperative Period; D011465:Prostaglandins, Synthetic / Q000627:therapeutic use*; D012189:Retrospective Studies; D014065:Tonometry, Ocular; D014129:Trabecular Meshwork / Q000601:surgery; D014130:Trabeculectomy; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology
chemical_list: D009883:Ophthalmic Solutions; D011465:Prostaglandins, Synthetic