title: Incidence of pseudotumor and acute lymphocytic vasculitis associated lesion (ALVAL) reactions in metal-on-metal hip articulations: a meta-analysis.
abstract: We systematically reviewed the peer-reviewed literature to determine a pooled estimate of the incidence of pseudotumor and acute lymphocytic vasculitis associated lesions (ALVAL) in adult patients with primary metal-on-metal (MoM) total hip arthroplasty or resurfacing. Fourteen eligible articles were identified, with a total of 13,898 MoM hips. The incidence of pseudotumor/ALVAL ranged from 0% to 6.5% of hips with a mean follow-up ranging from 1.7 to 12.3 years across the studies. The pooled estimated incidence of pseudotumor/ALVAL is 0.6% (95% CI: 0.3% to 1.2%). The rate of revision for any reason ranged from 0% to 14.3% of hips, with a pooled estimate of 3.9% (95% CI: 2.7% to 5.3%).
authors: University of Oklahoma College of Medicine, Oklahoma City, OK, USA.
authors: Kevin F
authors: KF
authors: Wiley
authors: Kai
authors: K
authors: Ding
authors: Julie A
authors: JA
authors: Stoner
authors: David C
authors: DC
authors: Teague
authors: Khalid M
authors: KM
authors: Yousuf
mesh_terms: D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation*; D005549:Foreign-Body Reaction / Q000453:epidemiology* / Q000209:etiology*; D006104:Granuloma, Plasma Cell / Q000453:epidemiology* / Q000209:etiology*; D006622:Hip Prosthesis; D006801:Humans; D015994:Incidence; D008206:Lymphatic Diseases / Q000453:epidemiology* / Q000209:etiology*; D008670:Metals; D011474:Prosthesis Design; D011475:Prosthesis Failure; D014657:Vasculitis / Q000453:epidemiology* / Q000209:etiology*
chemical_list: D008670:Metals
keywords: ALVAL; hip arthroplasty; hip resurfacing; hypersensitivity; metal-on-metal; pseudotumor