title: Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus.
abstract: The Japanese surveillance committee conducted the first nationwide surveillance of antimicrobial susceptibility patterns of uropathogens responsible for female acute uncomplicated cystitis at 43 hospitals throughout Japan from April 2009 to November 2010. In this study, the causative bacteria (Escherichia coli and Staphylococcus saprophyticus) and their susceptibility to various antimicrobial agents were investigated by isolation and culturing of bacteria from urine samples. In total, 387 strains were isolated from 461 patients, including E. coli (n = 301, 77.8 %), S. saprophyticus (n = 20, 5.2 %), Klebsiella pneumoniae (n = 13, 3.4 %), and Enterococcus faecalis (n = 11, 2.8 %). S. saprophyticus was significantly more common in premenopausal women (P = 0.00095). The minimum inhibitory concentrations of 19 antibacterial agents used for these strains were determined according to the Clinical and Laboratory Standards Institute manual. At least 87 % of E. coli isolates showed susceptibility to fluoroquinolones and cephalosporins, and 100 % of S. saprophyticus isolates showed susceptibility to fluoroquinolones and aminoglycosides. The proportions of fluoroquinolone-resistant E. coli strains and extended-spectrum β-lactamase (ESBL)-producing E. coli strains were 13.3 % and 4.7 %, respectively. It is important to confirm the susceptibility of causative bacteria for optimal antimicrobial therapy, and empiric antimicrobial agents should be selected by considering patient characteristics and other factors. However, the number of isolates of fluoroquinolone-resistant or ESBL-producing strains in gram-negative bacilli may be increasing in patients with urinary tract infections (UTIs) in Japan. Therefore, these data present important information for the proper treatment of UTIs and will serve as a useful reference for future surveillance studies.
authors: Urogenital sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JCS), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan. bass@m.kufm.kagoshima-u.ac.jp
authors: Hiroshi
authors: H
authors: Hayami
authors: Satoshi
authors: S
authors: Takahashi
authors: Kiyohito
authors: K
authors: Ishikawa
authors: Mitsuru
authors: M
authors: Yasuda
authors: Shingo
authors: S
authors: Yamamoto
authors: Shinya
authors: S
authors: Uehara
authors: Ryoichi
authors: R
authors: Hamasuna
authors: Tetsuro
authors: T
authors: Matsumoto
authors: Shinichi
authors: S
authors: Minamitani
authors: Akira
authors: A
authors: Watanabe
authors: Aikichi
authors: A
authors: Iwamoto
authors: Kyoichi
authors: K
authors: Totsuka
authors: Junichi
authors: J
authors: Kadota
authors: Keisuke
authors: K
authors: Sunakawa
authors: Junko
authors: J
authors: Sato
authors: Hideaki
authors: H
authors: Hanaki
authors: Taiji
authors: T
authors: Tsukamoto
authors: Hiroshi
authors: H
authors: Kiyota
authors: Shin
authors: S
authors: Egawa
authors: Kazushi
authors: K
authors: Tanaka
authors: Soichi
authors: S
authors: Arakawa
authors: Masato
authors: M
authors: Fujisawa
authors: Hiromi
authors: H
authors: Kumon
authors: Kanao
authors: K
authors: Kobayashi
authors: Akio
authors: A
authors: Matsubara
authors: Seiji
authors: S
authors: Naito
authors: Katsunori
authors: K
authors: Tatsugami
authors: Takamasa
authors: T
authors: Yamaguchi
authors: Shin
authors: S
authors: Ito
authors: Mototsugu
authors: M
authors: Kanokogi
authors: Harunori
authors: H
authors: Narita
authors: Hiromi
authors: H
authors: Kawano
authors: Takahide
authors: T
authors: Hosobe
authors: Kazuo
authors: K
authors: Takayama
authors: Toru
authors: T
authors: Sumii
authors: Akira
authors: A
authors: Fujii
authors: Takashi
authors: T
authors: Sato
authors: Takamine
authors: T
authors: Yamauchi
authors: Masanobu
authors: M
authors: Izumitani
authors: Hirofumi
authors: H
authors: Chokyu
authors: Hideari
authors: H
authors: Ihara
authors: Kikuo
authors: K
authors: Akiyama
authors: Masaru
authors: M
authors: Yoshioka
authors: Satoshi
authors: S
authors: Uno
authors: Koichi
authors: K
authors: Monden
authors: Motonori
authors: M
authors: Kano
authors: Shinichi
authors: S
authors: Kaji
authors: Shuichi
authors: S
authors: Kawai
authors: Kenji
authors: K
authors: Ito
authors: Hisato
authors: H
authors: Inatomi
authors: Hirofumi
authors: H
authors: Nishimura
authors: Toshihiro
authors: T
authors: Ikuyama
authors: Shohei
authors: S
authors: Nishi
authors: Koichi
authors: K
authors: Takahashi
authors: Yukihiro
authors: Y
authors: Kawano
authors: Satoshi
authors: S
authors: Ishihara
authors: Kengo
authors: K
authors: Tsuneyoshi
authors: Shinji
authors: S
authors: Matsushita
authors: Takashi
authors: T
authors: Yamane
authors: Takaoki
authors: T
authors: Hirose
authors: Shigeru
authors: S
authors: Fujihiro
authors: Katsuhisa
authors: K
authors: Endo
authors: Yasuhiko
authors: Y
authors: Oka
authors: Koh
authors: K
authors: Takeyama
authors: Takahiro
authors: T
authors: Kimura
authors: Tetsuji
authors: T
authors: Uemura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000453:epidemiology / Q000382:microbiology*; D003556:Cystitis / Q000453:epidemiology / Q000382:microbiology*; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D062486:Public Health Surveillance; D057790:Staphylococcus saprophyticus / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents