title: [Changing the paradigm of congenital heart disease: from the anatomy to the molecular etiology].
abstract: Heart development consists in a group of complex and specific morfogenetic interactions, that requires the proper activity of each factor implicated in this process. Congenital heart defects (CHD) are a group of multifactorial complex diseases with environmental and genetic factors playing important roles. There is not an exact relation between molecular mechanisms and morphological defects in CHD, because in most of the cases the proper development of an anatomical structure implies the adequate function of several pathways that may depend of the action of different genes. This review summarizes the genetic factors implied in the normal heart development and the most common gene mutations associated with CHD.
authors: Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
authors: Irma Eloísa
authors: IE
authors: Monroy-Muñoz
authors: Nonanzit
authors: N
authors: Pérez-Hernández
authors: Gilberto
authors: G
authors: Vargas-Alarcón
authors: Guillermo
authors: G
authors: Ortiz-San Juan
authors: Alfonso
authors: A
authors: Buendía-Hernández
authors: Juan
authors: J
authors: Calderón-Colmenero
authors: Samuel
authors: S
authors: Ramírez-Marroquín
authors: Jorge Luis
authors: JL
authors: Cervantes-Salazar
authors: Pedro
authors: P
authors: Curi-Curi
authors: Nancy
authors: N
authors: Martínez-Rodríguez
authors: José Manuel
authors: JM
authors: Rodríguez Pérez
mesh_terms: D006321:Heart / Q000033:anatomy & histology; D006330:Heart Defects, Congenital / Q000235:genetics*; D006331:Heart Diseases / Q000151:congenital* / Q000235:genetics*; D006801:Humans