title: Diffusion tensor imaging predicts the outcome of constraint-induced movement therapy in chronic infarction patients with hemiplegia: A pilot study.
abstract: OBJECTIVE
  To test whether diffusion tensor imaging could evaluate potential motor capability of patients with chronic cerebral infarction.
  
  
  METHODS
  We used constraint-induced movement therapy (CIMT) as a rehabilitation, which reveals potential motor capability. We also investigated the relationship between the outcome of CIMT and the ratio between fractional anisotropy values (rFA) in affected and unaffected sites of the corticospinal tract before CIMT. Imaging was performed in cerebral infarction patients (n = 14) and the rFA of the posterior limb of internal capsule (PLIC) was measured before CIMT. Patients were evaluated before and after CIMT using the Fugl-Meyer (F-M) assessment, Wolf Motor Function Test, Action Research Arm Test, and Motor Activity Log and association between PLIC- rFA and these scores was determined.
  
  
  RESULTS
  All patients showed an improvement in mobility following the 10-day CIMT session. Strong positive correlation was found only between F-M after CIMT and PLIC-rFA (r = 0.8098, p = 0.0004). A strong linear relationship was observed after CIMT.
  
  
  CONCLUSIONS
  These data support PLIC-rFA as a new marker of the CIMT-induced improvement in motor function (F-M).
authors: Department of Physical Medicine and Rehabilitation, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Japan. k.maru5081@gmail.com
authors: Kohei
authors: K
authors: Marumoto
authors: Tetsuo
authors: T
authors: Koyama
authors: Masashi
authors: M
authors: Hosomi
authors: Takashi
authors: T
authors: Takebayashi
authors: Keisuke
authors: K
authors: Hanada
authors: Sayaka
authors: S
authors: Ikeda
authors: Norihiko
authors: N
authors: Kodama
authors: Kazuhisa
authors: K
authors: Domen
mesh_terms: D000328:Adult; D000368:Aged; D016880:Anisotropy; D020520:Brain Infarction / Q000150:complications / Q000534:rehabilitation*; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging; D026241:Exercise Movement Techniques / Q000379:methods*; D005260:Female; D006429:Hemiplegia / Q000150:complications / Q000534:rehabilitation*; D006801:Humans; D020772:Internal Capsule / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010865:Pilot Projects; D011237:Predictive Value of Tests; D020127:Recovery of Function; D012149:Restraint, Physical; D012720:Severity of Illness Index; D055815:Young Adult