title: Percutaneous sclerotherapy of sialoceles after parotidectomy with fibrin glue, OK-432, and bleomycin.
abstract: We evaluated the curative effect of fibrin glue combined with OK-432 (streptococcal pyrogenic exotoxin A, Picibanil™) and bleomycin on 9 patients with sialoceles after parotidectomy. The primary lesions included pleomorphic adenomas in 6 cases and Warthin's tumours in 3 cases. After a sialocele had been diagnosed each patient had repeated aspirations and pressure dressings for 3-4 weeks, but these treatments failed. The patients were then treated with percutaneous sclerotherapy with the injection of fibrin glue 8-10 ml combined with OK-432 5 mg and bleomycin 15 mg. All the sialoceles disappeared completely after a single procedure in 2-3 weeks. The patients have been followed up for more than 6 months with no evidence of recurrent sialocele or injury to the facial nerve related to sclerotherapy. This simple, safe technique can be successfully used to treat sialoceles after parotidectomy.
authors: Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address: drchen@vip.163.com.
authors: Wei-liang
authors: WL
authors: Chen
authors: Li-ping
authors: LP
authors: Zhang
authors: Zhi-quan
authors: ZQ
authors: Huang
authors: Bin
authors: B
authors: Zhou
mesh_terms: D000235:Adenolymphoma / Q000601:surgery; D008949:Adenoma, Pleomorphic / Q000601:surgery; D000328:Adult; D001761:Bleomycin / Q000627:therapeutic use*; D003560:Cysts / Q000628:therapy*; D005154:Facial Nerve / Q000473:pathology; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000601:surgery; D010307:Parotid Neoplasms / Q000601:surgery*; D035421:Parotid Region / Q000473:pathology*; D010844:Picibanil / Q000627:therapeutic use*; D011183:Postoperative Complications; D012597:Sclerosing Solutions / Q000627:therapeutic use*; D015911:Sclerotherapy / Q000379:methods*; D013396:Suction / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015718:Fibrin Tissue Adhesive; D012597:Sclerosing Solutions; D001761:Bleomycin; D010844:Picibanil
keywords: Bleomycin; Fibrin glue; OK-432; Parotidectomy; Sialocele