title: Rab GTPase regulation of membrane identity.
abstract: A fundamental question in cell biology is how cells determine membrane compartment identity and the directionality with which cargoes pass through the secretory and endocytic pathways. The discovery of so-called 'Rab cascades' provides a satisfying molecular mechanism that helps to resolve this paradox. One Rab GTPase has the ability to template the localization of the subsequent acting Rab GTPase along a given transport pathway. Thus, in addition to determining compartment identity and functionality, Rab GTPases are likely able to order the events of membrane trafficking. This review will highlight recent advances in our understanding of Rabs and Rab cascades.
authors: Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive B400, Stanford, CA 94305-5307, USA. pfeffer@stanford.edu
authors: Suzanne R
authors: SR
authors: Pfeffer
mesh_terms: D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D004705:Endocytosis; D006801:Humans; D007425:Intracellular Membranes / Q000737:chemistry / Q000378:metabolism; D021381:Protein Transport; D055571:Secretory Pathway; D015003:Yeasts / Q000201:enzymology / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D020691:rab GTP-Binding Proteins
references: PLoS Comput Biol. 2011 Oct;7(10):e1002217
references: 22022256
references: J Biol Chem. 2012 Dec 7;287(50):42129-37
references: 23091056
references: Nat Cell Biol. 2002 Feb;4(2):124-33
references: 11788822
references: Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1991-6
references: 22308417
references: PLoS One. 2011 May 10;6(5):e19764
references: 21572956
references: Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19614-8
references: 21045128
references: J Biol Chem. 2010 Mar 5;285(10):7794-804
references: 20048159
references: Nat Rev Mol Cell Biol. 2009 Aug;10(8):513-25
references: 19603039
references: J Biol Chem. 2012 Jun 29;287(27):22740-8
references: 22637480
references: Nature. 1994 Mar 10;368(6467):157-60
references: 8139660
references: Nature. 2010 Apr 1;464(7289):778-82
references: 20305638
references: Nature. 2003 Oct 23;425(6960):856-9
references: 14574414
references: Cell. 2004 Feb 6;116(3):445-56
references: 15016378
references: Biosci Rep. 2011 Jun;31(3):159-68
references: 21250943
references: Nat Rev Mol Cell Biol. 2012 Jan 18;13(2):67-73
references: 22251903
references: Curr Biol. 2010 Sep 28;20(18):1654-9
references: 20797862
references: J Mol Biol. 2000 Dec 8;304(4):585-98
references: 11099382
references: Dev Cell. 2012 May 15;22(5):952-66
references: 22595670
references: J Cell Biol. 2002 Feb 4;156(3):511-8
references: 11827983
references: J Mol Biol. 2009 Jun 5;389(2):275-88
references: 19361519
references: Cell. 2010 Apr 30;141(3):404-6
references: 20434982
references: Cell. 2008 Jan 25;132(2):286-98
references: 18243103
references: J Cell Biol. 2000 May 15;149(4):901-14
references: 10811830
references: J Cell Sci. 2012 May 15;125(Pt 10):2500-8
references: 22366452
references: J Cell Biol. 2013 Feb 4;200(3):287-300
references: 23382462
references: Mol Syst Biol. 2008;4:206
references: 18628746
references: J Cell Biol. 2006 Jun 19;173(6):917-26
references: 16769818
references: Curr Biol. 2012 Nov 20;22(22):2135-9
references: 23084991
references: Cell. 1997 Sep 19;90(6):1149-59
references: 9323142
references: J Biol Chem. 2011 Sep 23;286(38):33213-22
references: 21808068
references: J Cell Biol. 2002 Jun 10;157(6):1005-15
references: 12045183
references: Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21348-53
references: 23236136
references: Physiol Rev. 2011 Jan;91(1):119-49
references: 21248164
references: Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18672-7
references: 22065758
references: Cell. 2005 Sep 9;122(5):735-49
references: 16143105
references: Cell. 1987 May 22;49(4):527-38
references: 3552249
references: Nature. 2009 Jun 25;459(7250):1091-7
references: 19458617
references: Mol Biol Cell. 2012 Feb;23(4):669-78
references: 22171327
references: Semin Cell Dev Biol. 2011 Feb;22(1):48-56
references: 20951823
references: Cell. 2010 Apr 30;141(3):497-508
references: 20434987
references: Curr Biol. 2012 Aug 7;22(15):1381-90
references: 22748321
references: Nature. 1994 May 5;369(6475):76-8
references: 8164745
references: EMBO J. 2011 Aug 31;30(17):3481-500
references: 21878991
references: Annu Rev Biochem. 2012;81:637-59
references: 22463690
references: PLoS One. 2012;7(4):e34870
references: 22523562
references: Cell. 1986 Nov 7;47(3):401-12
references: 3094963
references: PLoS Biol. 2005 Jul;3(7):e233
references: 15954801
references: Curr Opin Cell Biol. 2010 Aug;22(4):461-70
references: 20466531
references: Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14408-13
references: 19666511
references: Cell. 1990 Jul 27;62(2):317-29
references: 2115402