title: Effect of rhBMP-2 upon maxillary sinus augmentation: a comprehensive review.
abstract: OBJECTIVE
  The purpose of this review was to summarize the recent in vitro and in vivo research findings in areas where rhBMP-2 was used as a grafting material for sinus augmentation.
  
  
  METHODS
  An electronic literature search for relevant articles published in English was conducted in the PubMed database from February 1996 to August 2012. Randomized clinical trials or prospective human clinical and animal trials were included with the primary objective to compare and evaluate the effectiveness of rhBMP-2 for sinus augmentation.
  
  
  RESULTS
  A total of 3 human studies and 4 animal trials qualified the selection criteria that were included in this review. In humans, the selected studies indicated that rhBMP-2 induces new bone formation with comparable bone quality or amount of newly formed bone to that induced by autogenous bone graft. Furthermore, no differences have been reported between new bone induced by rhBMP-2 and native bone. Animal model studies also demonstrated regular bone formation induced by rhBMP-2, followed by normal maturation of new bone.
  
  
  CONCLUSIONS
  All these studies demonstrate the osteoinductive and osteogenic capacity of rhBMP-2 and support it as an alternative for autogenous bone in sinus floor augmentation.
authors: Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Granada, Spain.
authors: Laura
authors: L
authors: Torrecillas-Martinez
authors: Alberto
authors: A
authors: Monje
authors: Michael A
authors: MA
authors: Pikos
authors: Inmaculada
authors: I
authors: Ortega-Oller
authors: Fernando
authors: F
authors: Suarez
authors: Pablo
authors: P
authors: Galindo-Moreno
authors: Hom-Lay
authors: HL
authors: Wang
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000009:adverse effects / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004336:Drug Antagonism; D006801:Humans; D023421:Models, Animal; D011994:Recombinant Proteins; D059546:Sinus Floor Augmentation / Q000379:methods*
chemical_list: D055396:Bone Morphogenetic Protein 2; D018786:Bone Substitutes; D011994:Recombinant Proteins