title: Reversible chemoselective tagging and functionalization of methionine containing peptides.
abstract: Reagents were developed to allow chemoselective tagging of methionine residues in peptides and polypeptides, subsequent bioorthogonal functionalization of the tags, and cleavage of the tags when desired. This methodology can be used for triggered release of therapeutic peptides, or release of tagged protein digests from affinity columns.
authors: Department of Chemistry and Biochemistry, Department of Bioengineering, HS-SEAS, University of California, 5121 Engineering 5, Los Angeles, CA 90095, USA.
authors: Jessica R
authors: JR
authors: Kramer
authors: Timothy J
authors: TJ
authors: Deming
mesh_terms: D000477:Alkylating Agents / Q000737:chemistry*; D000595:Amino Acid Sequence; D006801:Humans; D007202:Indicators and Reagents; D008715:Methionine / Q000032:analysis*; D010455:Peptides / Q000737:chemistry*
chemical_list: D000477:Alkylating Agents; D007202:Indicators and Reagents; D010455:Peptides; D008715:Methionine