title: Severe thrombocytopenia complicating transcatheter occlusion of a patent ductus arteriosus.
abstract: Transcatheter closure of a patent ductus arteriosus (PDA) is a well-established technique that may occasionally be complicated by severe thrombocytopenia. We report herein 6 cases of PDA in which circulating platelet counts were notably reduced within 18-48 hours following the procedure. A number of interventions, including blood-pressure control, protection against hemorrhage, and eradication of residual flow, were performed. Platelet counts in all patients were restored to preprocedural levels through intravenous infusion of dexamethasone and human gamma globulin.
authors: Department of Congenital Heart Disease, Cardiovascular Research Institute of PLA, General Hospital of Shenyang Military Command, Shenyang City, Liaoning Province, China.
authors: Po
authors: P
authors: Zhang
authors: Xian-yang
authors: XY
authors: Zhu
mesh_terms: D000328:Adult; D006328:Cardiac Catheterization / Q000009:adverse effects* / Q000379:methods*; D002675:Child, Preschool; D003907:Dexamethasone / Q000627:therapeutic use; D004374:Ductus Arteriosus, Patent / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010976:Platelet Count; D012307:Risk Factors; D055989:Septal Occluder Device; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D016896:Treatment Outcome; D005719:gamma-Globulins / Q000627:therapeutic use
chemical_list: D005719:gamma-Globulins; D003907:Dexamethasone