title: Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment.
abstract: To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers induced apoptosis and reduced cell density as a result of cell differentiation and/or apoptosis. Flow cytometry revealed that 9-cis RA induced apoptosis more effectively than ATRA. The expression profile of apoptosis and survival pathways was cell line specific and depended on the isomer used.
authors: Department of Health Sciences, Public University of Navarra, Pamplona, Spain.
authors: Jon
authors: J
authors: Celay
authors: Idoia
authors: I
authors: Blanco
authors: Paula
authors: P
authors: Lázcoz
authors: Mirja
authors: M
authors: Rotinen
authors: Javier S
authors: JS
authors: Castresana
authors: Ignacio
authors: I
authors: Encío
mesh_terms: D000077556:Alitretinoin; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000235:genetics*; D045744:Cell Line, Tumor; D048430:Cell Shape / Q000187:drug effects; D002470:Cell Survival; D019008:Drug Resistance, Neoplasm; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D009447:Neuroblastoma; D059467:Transcriptome / Q000187:drug effects*; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D000077556:Alitretinoin; D014212:Tretinoin
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