title: Mortality following bone metastasis and skeletal-related events among patients 65 years and above with lung cancer: A population-based analysis of U.S. Medicare beneficiaries, 1999-2006.
abstract: BACKGROUND
  To quantify the impact of bone metastasis and skeletal-related events (SREs) on mortality among older patients with lung cancer.
  
  
  METHODS
  Using the linked Surveillance, Epidemiology and End Results-Medicare database, we identified patients aged 65 years or older diagnosed with lung cancer between July 1, 1999 and December 31, 2005 and followed them to determine deaths through December 31, 2006. We classified patients as having possible bone metastasis and SREs using discharge diagnoses from inpatient claims and diagnoses paired with procedure codes from outpatient claims. We used Cox regression to estimate mortality hazards ratios (HR) among patients with bone metastasis with or without SRE, compared to patients without bone metastasis.
  
  
  RESULTS
  Among 126,123 patients with lung cancer having a median follow-up of 0.6 years, 24,820 (19.8%) had bone metastasis either at lung cancer diagnosis (9,523, 7.6%) or during follow-up (15,297, 12.1%). SREs occurred in 12,665 (51%) patients with bone metastasis. The HR for death was 2.4 (95% CI = 2.4-2.5) both for patients with bone metastasis but no SRE and for patients with bone metastasis plus SRE, compared to patients without bone metastasis.
  
  
  CONCLUSIONS
  Having a bone metastasis, as indicated by Medicare claims, was associated with mortality among patients with lung cancer. We found no difference in mortality between patients with bone metastasis complicated by SRE and patients with bone metastasis but without SRE.
authors: School of Public Health, University of Alabama at Birmingham. 1665 University Blvd, Birmingham, AL. 35294-0022, USA.
authors: Nalini
authors: N
authors: Sathiakumar
authors: Elizabeth
authors: E
authors: Delzell
authors: Michael A
authors: MA
authors: Morrisey
authors: Carla
authors: C
authors: Falkson
authors: Mellissa
authors: M
authors: Yong
authors: Victoria
authors: V
authors: Chia
authors: Justin
authors: J
authors: Blackburn
authors: Tarun
authors: T
authors: Arora
authors: Meredith L
authors: ML
authors: Kilgore
keywords: Claims; SEER; distant stage; fractures; mortality
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