title: Enzymological evaluation of hepatotropic effect of ozone in a subchronic experiment.
abstract: Hepatotoxicity of ozone in total systems treatment was evaluated by the functioning of hepatic oxidoreductases. Activities of lactate dehydrogenase and alcohol dehydrogenase were measured in liver homogenates of Wistar rats, injected daily with saline with saturating ozone concentrations of 3000, 10,000, and 40,000 μg/liter or placebo for 30 days. Systemic ozone treatment had a two-step effect on the hepatic oxidoreductases. Low doses (0.6 μg) promoted a moderate physiological stimulation of the enzymes, while in doses >2 μg ozone led to progressive tissue hypoxia and accumulation of toxic products in the liver.
authors: Nizhny Novgorod Institute of Traumatology and Orthopedics, Russia.
authors: S P
authors: SP
authors: Peretyagin
authors: A K
authors: AK
authors: Martusevich
authors: A G
authors: AG
authors: Solovyeva
authors: Yu V
authors: YV
authors: Zimin
authors: P V
authors: PV
authors: Peretyagin
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000378:metabolism*; D000818:Animals; D015687:Cell Hypoxia; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D010083:Oxidants, Photochemical / Q000633:toxicity*; D010126:Ozone / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010083:Oxidants, Photochemical; D010126:Ozone; D007770:L-Lactate Dehydrogenase; D000444:Aldehyde Dehydrogenase