title: Manzamenone O, new trimeric fatty acid derivative from a marine sponge Plakortis sp.
abstract: A new structurally unique trimeric fatty acid derivative, manzamenone O (1), was isolated from a marine sponge Plakortis sp. Manzamenone O (1) has a novel skeleton consisting of C-C bonded octahydroindenone and dioxabicyclo[3.3.0]octane moieties and three long aliphatic chains. The structure of 1 was elucidated on the basis of spectroscopic data and conformational analysis. Manzamenone O (1) exhibited antimicrobial activity against Micrococcus luteus, Aspergillis niger, and Trichophyton mentagrophytes.
authors: Graduate School of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan, Mycology Research Center, Chiba University , Chiba 260-0856, Japan, and Western Australian Museum , Locked Bag 49, Weishpool DC, WA 6986, Australia.
authors: Naonobu
authors: N
authors: Tanaka
authors: Miki
authors: M
authors: Asai
authors: Azusa
authors: A
authors: Takahashi-Nakaguchi
authors: Tohru
authors: T
authors: Gonoi
authors: Jane
authors: J
authors: Fromont
authors: Jun'ichi
authors: J
authors: Kobayashi
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005227:Fatty Acids / Q000737:chemistry* / Q000302:isolation & purification; D007192:Indenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D047229:Plakortis / Q000737:chemistry*; D061065:Polyketides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D005227:Fatty Acids; D007192:Indenes; D061065:Polyketides; C000588676:manzamenone O