title: [Precancerous tumors and carcinomas in situ of the skin].
abstract: Precancerous skin lesions and carcinomas in situ of the skin represent the early stages of epithelial skin tumors. There is no invasive tumor growth, so the basement membrane is completely intact. These lesions show a wide variation of clinical and histological appearances on the skin or mucosa. The precancerous and carcinoma in situ lesions that are described in this text are actinic keratosis, actinic cheilitis, cutaneous horns, arsenical keratosis, tar-induced dermatosis, X-ray irradiation-related keratosis, Bowen's disease, erythroplasia of Queyrat, bowenoid papulosis, intraepithelial neoplasia (vulvar, penile and anal). Because they all can progress into invasive carcinoma, therapy is mandatory. Many noninvasive therapeutic approaches exist nowadays in the form of gels, creams, photodynamic therapy and invasive techniques such as laser therapy and cryotherapy, curettage and excision of lesional skin. Depending on the treatment process, different rates of general clearance and recurrence of the lesions are discussed in this article.
authors: Klinik für Dermatologie, Venerologie und Allergologie, Hauttumorcentrum, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland. daniela.krueger-corcoran@charite.de
authors: D
authors: D
authors: Krüger-Corcoran
authors: S
authors: S
authors: Vandersee
authors: E
authors: E
authors: Stockfleth
mesh_terms: D062109:Dermatologic Surgical Procedures / Q000379:methods*; D003937:Diagnosis, Differential; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D011230:Precancerous Conditions / Q000473:pathology* / Q000517:prevention & control*; D063465:Skin Cream / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000473:pathology* / Q000517:prevention & control*
references: J Dtsch Dermatol Ges. 2003 Jul;1(7):569-78; quiz 580-1
references: 16295043
references: Arch Dermatol. 2004 Dec;140(12):1542
references: 15611446
references: Hautarzt. 2010 Mar;61(3):220-9
references: 20165825
references: J Dtsch Dermatol Ges. 2012 Dec;10 Suppl 7:S1-23
references: 23110516
references: Hautarzt. 1989 Sep;40(9):556-8
references: 2807916
references: Br J Dermatol. 2007 May;156 Suppl 3:8-12
references: 17488400
references: J Eur Acad Dermatol Venereol. 2011 Mar;25(3):276-84
references: 20626536
references: Br J Dermatol. 2003 Nov;149 Suppl 66:43-9
references: 14616349
references: J Am Acad Dermatol. 2000 Jul;43(1 Pt 1):138-50
references: 10863242
references: Eur J Obstet Gynecol Reprod Biol. 2003 Aug 15;109(2):224-7
references: 12860347
references: G Ital Dermatol Venereol. 2009 Aug;144(4):459-62
references: 19755950
references: Br J Dermatol. 2007 May;156 Suppl 3:43-6
references: 17488406
references: Lasers Surg Med. 2002;30(4):273-9
references: 11948597
references: Hautarzt. 2001 Jan;52(1):6-17
references: 11220242
references: Acta Derm Venereol. 1988;68(3):236-9
references: 2455417
references: Hautarzt. 2005 May;56(5):430-40
references: 15815888
references: Arch Dermatol. 2002 Nov;138(11):1498-502
references: 12437457
references: Br J Dermatol. 2006 Jul;155(1):9-22
references: 16792746