title: Supplementation with selenium-enriched yeast attenuates brain metastatic growth.
abstract: Metastases are the leading cause of cancer mortality and their development may be affected by diet. The aim of this study was to compare the effects of dietary supplementation with different selenium (Se) compounds on the dynamics of brain metastasis development in a novel mouse model. Mice were fed experimental diets enriched (1 mg/kg) with sodium selenite (Se-S), seleno-1-methionine (Se-Meth), a yeast-derived organic form of selenium (Se-Yeast), or a control diet (Se < 0.05 mg/kg) for 20 wk. At the end of the feeding period, animals were injected with luciferase-tagged K1735 (K1735-Luc) melanoma cells into the brain vasculature. The development of brain metastatic tumors was monitored for 2 wk following injection. Mice bearing brain metastatic tumors and fed Se-Yeast- or Se-S-enriched diets displayed a higher survival rate compared with other experimental and control groups. Importantly, Se-Yeast supplementation decreased the growth of brain metastatic tumors as determined by the measurement of the intensity of the bioluminescent signal emitted by K1735-Luc cells upon reaction with luciferin. Different chemical forms of Se have distinct effects on the development of brain metastases. Organic Se in the form of Se-Yeast may be a valuable agent in suppression of brain metastatic disease.
authors: Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33136, USA.
authors: Jagoda K
authors: JK
authors: Wrobel
authors: Melissa J
authors: MJ
authors: Seelbach
authors: Lei
authors: L
authors: Chen
authors: Ronan F
authors: RF
authors: Power
authors: Michal
authors: M
authors: Toborek
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D001932:Brain Neoplasms / Q000178:diet therapy* / Q000401:mortality / Q000473:pathology*; D002465:Cell Movement / Q000187:drug effects; D019587:Dietary Supplements; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000178:diet therapy / Q000473:pathology; D012643:Selenium / Q000494:pharmacology*; D015002:Yeast, Dried / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D012643:Selenium