title: Normality index of ventricular contraction based on a statistical model from FADS.
abstract: Radionuclide-based imaging is an alternative to evaluate ventricular function and synchrony and may be used as a tool for the identification of patients that could benefit from cardiac resynchronization therapy (CRT). In a previous work, we used Factor Analysis of Dynamic Structures (FADS) to analyze the contribution and spatial distribution of the 3 most significant factors (3-MSF) present in a dynamic series of equilibrium radionuclide angiography images. In this work, a probability density function model of the 3-MSF extracted from FADS for a control group is presented; also an index, based on the likelihood between the control group's contraction model and a sample of normal subjects is proposed. This normality index was compared with those computed for two cardiopathic populations, satisfying the clinical criteria to be considered as candidates for a CRT. The proposed normality index provides a measure, consistent with the phase analysis currently used in clinical environment, sensitive enough to show contraction differences between normal and abnormal groups, which suggests that it can be related to the degree of severity in the ventricular contraction dyssynchrony, and therefore shows promise as a follow-up procedure for patients under CRT.
authors: Nuclear Cardiology Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1 Colonia Seccion XVI, Tlalpan, 14080 Mexico City, DF, Mexico. luis.jimenez@ieee.org
authors: Luis
authors: L
authors: Jiménez-Ángeles
authors: Raquel
authors: R
authors: Valdés-Cristerna
authors: Enrique
authors: E
authors: Vallejo
authors: David
authors: D
authors: Bialostozky
authors: Verónica
authors: V
authors: Medina-Bañuelos
mesh_terms: D000465:Algorithms; D058406:Cardiac Resynchronization Therapy; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D019295:Computational Biology; D005163:Factor Analysis, Statistical; D005583:Fourier Analysis; D015637:Gated Blood-Pool Imaging / Q000706:statistics & numerical data; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D015233:Models, Statistical; D009200:Myocardial Contraction / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D016276:Ventricular Function / Q000502:physiology*
references: Pacing Clin Electrophysiol. 2003 Sep;26(9):1815-23
references: 12930495
references: J Am Coll Cardiol. 2004 Aug 18;44(4):810-9
references: 15312864
references: J Nucl Med. 2007 Dec;48(12):2001-10
references: 18056333
references: JACC Cardiovasc Imaging. 2008 Sep;1(5):561-8
references: 19356481
references: Int J Cardiovasc Imaging. 2009 Jan;25(1):1-11
references: 18633727
references: J Am Coll Cardiol. 2002 Jun 19;39(12):2026-33
references: 12084604
references: Am J Cardiol. 2004 Jun 15;93(12):1504-9
references: 15194021
references: J Am Coll Cardiol. 2005 Sep 20;46(6):e1-82
references: 16168273
references: Eur J Nucl Med. 1983;8(5):218-22
references: 6603360
references: J Am Coll Cardiol. 2006 May 16;47(10):2042-8
references: 16697323
references: Circ Cardiovasc Imaging. 2011 Mar;4(2):114-21
references: 21239562
references: N Engl J Med. 1994 Dec 8;331(23):1564-75
references: 7969328
references: Int J Cardiovasc Imaging. 2010 Feb;26(2):199-202
references: 20039137
references: J Nucl Cardiol. 2005 Nov-Dec;12(6):687-95
references: 16344231
references: Circulation. 2008 May 20;117(20):2608-16
references: 18458170
references: J Am Coll Cardiol. 2000 Apr;35(5):1221-7
references: 10758964
references: Int J Cardiovasc Imaging. 2008 Oct;24(7):717-25
references: 18373280
references: Am J Cardiol. 1984 Jul 1;54(1):147-52
references: 6741806
references: Circulation. 2003 Nov 25;108(21):2596-603
references: 14638522
references: J Nucl Cardiol. 2005 Mar-Apr;12(2):208-15
references: 15812376
references: J Nucl Cardiol. 2005 Jul-Aug;12(4):441-50
references: 16084433
references: Phys Med Biol. 1980 Mar;25(2):283-92
references: 7384214
references: Int J Cardiovasc Imaging. 2002 Jun;18(3):187-94
references: 12123310
references: Eur Heart J. 2000 Aug;21(15):1246-50
references: 10924314
references: Am J Cardiol. 1996 Jun 1;77(14):1185-90
references: 8651093
references: J Am Coll Cardiol. 2002 Dec 4;40(11):2022-30
references: 12475464
references: Int J Card Imaging. 1995 Dec;11(4):263-72
references: 8596065
references: Circulation. 1982 Mar;65(3):551-60
references: 7055877
references: Europace. 2008 Mar;10(3):336-46
references: 18308754
references: Am J Cardiol. 1993 Mar 15;71(8):720-6
references: 8447272
references: Am J Cardiol. 2003 Aug 1;92(3):341-4
references: 12888151
references: Circulation. 2009 Jan 27;119(3):e21-181
references: 19075105
references: Eur J Echocardiogr. 2004 Oct;5(5):335-46
references: 15341869
references: Int J Cardiovasc Imaging. 2010 Feb;26(2):177-91
references: 19937388
references: Int J Cardiol. 1999 Jul 31;70(2):171-8
references: 10454306
references: Am J Cardiol. 1979 Jun;43(6):1159-66
references: 443176
references: N Engl J Med. 2005 Apr 14;352(15):1539-49
references: 15753115