title: Re-analysis of expression profiles for revealing new potential candidate genes of heart failure.
abstract: BACKGROUND
  Chronic heart failure (HF) is characterized by diminished cardiac output and pooling of blood in the venous system.
  
  
  OBJECTIVE
  We used the GSE1145 microarray data to identify potential genes that related to heart failure to construct a regulation network.
  
  
  METHODS
  In the network, some of transcription factors (TFs) and target genes have been proved to be related to heart failure in previous study. The gene MYC, RELA, HIF1A, NFκB1 and SMAD3 are as hub nodes in our transcriptional network and have a close relationship with heart failure.
  
  
  RESULTS
  The study did not address regulation network but researched for the significant pathways related to chronic heart failure. Besides, RELA and NFκB1 interfere with each other in response to HF.
  
  
  CONCLUSIONS
  It is demonstrated that transcriptional network analysis is useful in identification of the candidate genes in heart failure.
authors: Department of Medical Cardiology, Tongji Hospital, Affiliated to Tongji University, Shanghai, China.
authors: H B
authors: HB
authors: Chen
authors: L
authors: L
authors: Wang
authors: J F
authors: JF
authors: Jiang
mesh_terms: D000943:Antigens, Differentiation / Q000235:genetics; D018932:Chemokine CCL2 / Q000235:genetics; D053263:Gene Regulatory Networks; D016259:Genes, myc; D006333:Heart Failure / Q000235:genetics*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics; D059467:Transcriptome; D000097642:GADD45 Proteins
chemical_list: D000943:Antigens, Differentiation; D018932:Chemokine CCL2; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C111835:CCL2 protein, human; C086470:GADD45B protein, human; D000097642:GADD45 Proteins; C497442:HIF1A protein, human