title: Development of JAK2V617F-positive polycythemia vera after chemotherapy-induced remission of primary central nervous system diffuse large B cell non-Hodgkin's lymphoma: a case report and review of the literature.
abstract: The coexistence or the development of Philadelphia chromosome-negative myeloproliferative neoplasms after a lymphoproliferative disease in the same patient is an extremely rare event. We report the case of a 72-year-old man who developed JAK2V617F polycythemia vera 3 years after the diagnosis and treatment of primary diffuse large B cell non-Hodgkin's lymphoma of the central nervous system. We also review the literature regarding the pathogenesis underlying the association of myeloproliferative and lymphoproliferative chronic disorders.
authors: Hematology Division, Ospedale San Gerardo, Università degli Studi Milano Bicocca, Monza, Italy.
authors: E M
authors: EM
authors: Elli
authors: A
authors: A
authors: Belotti
authors: C
authors: C
authors: Cecchetti
authors: S
authors: S
authors: Realini
authors: M
authors: M
authors: Fedele
authors: M
authors: M
authors: Parma
authors: E M
authors: EM
authors: Pogliani
mesh_terms: D000368:Aged; D019943:Amino Acid Substitution; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D003561:Cytarabine; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D008727:Methotrexate; D020125:Mutation, Missense; D011087:Polycythemia Vera / Q000139:chemically induced* / Q000175:diagnosis / Q000235:genetics*
chemical_list: D003561:Cytarabine; C507924:JAK2 protein, human; D053614:Janus Kinase 2; D008727:Methotrexate