title: Imaging of integrin α(V)β(3) expression using (68)Ga-RGD positron emission tomography in pediatric cerebral infarct.
abstract: Enhanced expression of integrin αvβ3 is commonly used as a biomarker for angiogenesis, which is one of the key pathophysiologic processes in cerebral infarct. Integrin αvβ3 can be imaged with arginine-glycine-aspartic acid (RGD) peptide agents. In this study, characteristics of positron emission tomography (PET) using a 68Ga-labeled RGD were investigated in pediatric cerebral infarct. Pediatric patients with moyamoya disease underwent 68Ga-RGD PET in a research protocol for neovascularization evaluation. In these patients, 17 cerebral infarct lesions of 10 patients were included in the analysis. On 68Ga-RGD PET, the infarct lesion to contralateral brain ratio (LCR) of the infarct lesion was measured and analyzed with regard to postinfarct time interval (PTI) and perfusion single-photon emission computed tomography (SPECT) findings. An increase in 68Ga-RGD uptake was observed in cerebral infarct, particularly in recent lesions. The LCR was significantly higher in the recent than in the chronic lesions, and a significant correlation existed between the LCR and PTI. Additionally, the LCR was significantly higher in the lesions with hyperperfusion on SPECT. This study, as the first human study using an RGD agent for in vivo cerebral infarct imaging, demonstrated that 68Ga-RGD PET has a potential for molecular imaging of integrin αvβ3 expression in cerebral infarct as a biomarker of angiogenesis.
authors: Hongyoon
authors: H
authors: Choi
authors: Ji Hoon
authors: JH
authors: Phi
authors: Jin Chul
authors: JC
authors: Paeng
authors: Seung-Ki
authors: SK
authors: Kim
authors: Yun-Sang
authors: YS
authors: Lee
authors: Jae Min
authors: JM
authors: Jeong
authors: June-Key
authors: JK
authors: Chung
authors: Dong Soo
authors: DS
authors: Lee
authors: Kyu-Chang
authors: KC
authors: Wang
mesh_terms: D000293:Adolescent; D002544:Cerebral Infarction / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism*; D008297:Male; D009842:Oligopeptides / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000379:methods*; D011446:Prospective Studies; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005710:Gallium Radioisotopes; D039302:Integrin alphaVbeta3; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid