title: Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection.
abstract: A setup is proposed that provides perfectly co-registered photoacoustic (PA) and ultrasound (US) section images. Photoacoustic and ultrasound backscatter signals are generated by laser pulses coming from the same laser system, the latter by absorption of some of the laser energy on an optically absorbing target near the imaged object. By measuring both signals with the same optical detector, which is focused into the selected section by use of a cylindrical acoustic mirror, the information for both images is acquired simultaneously. Co-registered PA and US images are obtained after applying the inverse Radon transform to the data, which are gathered while rotating the object relative to the detector. Phantom experiments demonstrate a resolution of 1.1 mm between the sections of both imaging modalities and a in-plane resolution of about 60 µm and 120 µm for the US and PA modes, respectively. The complementary contrast mechanisms of the two modalities are shown by images of a zebrafish.
authors: Department of Physics, Karl-Franzens University Graz, 8010 Graz, Austria. ro.nuster@uni-graz.at
authors: Robert
authors: R
authors: Nuster
authors: Nicole
authors: N
authors: Schmitner
authors: Gerhild
authors: G
authors: Wurzinger
authors: Sibylle
authors: S
authors: Gratt
authors: Willi
authors: W
authors: Salvenmoser
authors: Dirk
authors: D
authors: Meyer
authors: Guenther
authors: G
authors: Paltauf
mesh_terms: D000818:Animals; D005260:Female; D008544:Melanocytes / Q000166:cytology; D064847:Multimodal Imaging / Q000379:methods*; D055620:Optical Phenomena; D061088:Photoacoustic Techniques; D014465:Ultrasonics; D015027:Zebrafish