title: Chinese herbal medicines for induction of remission in advanced or late gastric cancer.
abstract: BACKGROUND
  Gastric cancer is difficult to cure once it progresses to an advanced or late stage. Although some chemotherapies or bio-therapies have made progress in the remission of this disease, the mortality from gastric cancer remains high. A variety of Chinese medicinal herbs have been used to treat gastric cancer.
  
  
  OBJECTIVE
  To assess the effectiveness of Chinese medicinal herbs in the short-term remission of advanced or late gastric cancer.
  
  
  METHODS
  We searched the The Cochrane Library, MEDLINE, EMBASE, AHMED (Allied and Complementary Medicine Database) and CBM (Chinese Biomedical Database) from the first year of the databases to June 2011. We handsearched a number of journals.
  
  
  METHODS
  All randomised clinical trials of Chinese herbs for advanced or late gastric cancer were included.
  
  
  METHODS
  Two authors independently extracted the data, which were analysed using RevMan 5.1 software (RevMan 2011). For dichotomous data, we estimated the relative risk. For continuous data, we calculated the weighted mean difference.
  
  
  RESULTS
  Eighty-five trials with 6857 advanced or late gastric cancer patients were identified for inclusion, most were of low quality and used traditional Chinese medicinal herbs (TCMHs) plus chemotherapy compared with the same chemotherapy alone (65 trials). Apart from 23 trials of four different kinds of TCMHs, we could not pool the results because no more than two used the same intervention or outcomes.TCMHs with or without chemotherapy, in 57 trials, showed statistically significant differences for the improvement of mortality in nine trials, quality of life in 16 trials, rate of remission in 11 trials, and leukopenia in five trials. The pooled results from the four injected TCMHs, Huachansu, Aidi, Fufangkushen, and Shenqifuzheng showed statistically significant differences for the improvement of leukopenia, but no significant difference in the rate of short-term remission.
  
  
  CONCLUSIONS
  This review did not provide assured evidence concerning the effectiveness of TCMHs in improving quality of life or rate of remission, alleviating the toxicity or side effects of chemotherapy, or reducing short-term mortality. Limited, weak evidence showed that Huachansu, Aidi, Fufangkushen, and Shenqifuzheng improved leukopenia when used together with chemotherapy; and Huachansu, Aidi, and Fufangkushen were of benefit for adverse events in the digestive system caused by chemotherapy. These TCMHs did not improve the rate of short-term remissions. Large, well designed clinical trials are required urgently before any definite conclusions can be drawn about the value of TCMHs for advanced or late stage gastric cancer.
authors: Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China. mouse-577@163.com.
authors: Jinlin
authors: J
authors: Yang
authors: Linlin
authors: L
authors: Zhu
authors: Zongying
authors: Z
authors: Wu
authors: Yiping
authors: Y
authors: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012074:Remission Induction / Q000379:methods; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal
references: Cochrane Database Syst Rev. 2007 Apr 18;(2):CD004921
references: 17443560
references: Digestion. 2008;77(2):87-91
references: 18376129
references: Zhong Xi Yi Jie He Xue Bao. 2006 Sep;4(5):478-81
references: 16965740
references: Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Aug;19(8):470-2
references: 11783226
references: World J Gastroenterol. 2003 Apr;9(4):670-3
references: 12679907
references: Stat Med. 1998 Dec 30;17(24):2815-34
references: 9921604
references: Phytother Res. 2002 Mar;16(2):138-42
references: 11933115
references: Cochrane Database Syst Rev. 2007 Oct 17;(4):CD006054
references: 17943880
references: Cochrane Database Syst Rev. 2005 Jan 25;(1):CD004540
references: 15674951
references: J Ethnopharmacol. 2009 May 4;123(1):91-6
references: 19429345