title: Cell Based Autologous Immune Enhancement Therapy (AIET) after Radiotherapy in a Locally Advanced Carcinoma of the Cervix.
abstract: Radiotherapy is the primary form of treatment in patients with locally advanced cervical carcinoma. However for residual disease in the form of the persistent lymph nodes, surgery or chemotherapy is recommended. As surgery is not acceptable by every patient and chemotherapy has associated side effects, we hereby report the positive outcome of in vitro expanded natural killer cell and activated T lymphocyte based autologous immune enhancement therapy (AIET) for the residual lymphadenopathy in a patient with locally advanced cervical cancer after radiation. After six transfusions of AIET, there was complete resolution of residual lymph nodes and there was no evidence of local lesion. The patient also reported improvement in quality of life. As AIET has been reported as the least toxic among the available therapies for cancer, combining AIET with conventional forms of therapy in similar patients might not only improve the outcome but may also help the patients achieve a good quality of life.
authors: Chennai Meenakshi Multispeciality Hospital Limited, New No. 72, Old No. 148, Luz Church Road, Mylapore, Chennai 600 004, India ; Dr. Kamakshi Memorial Hospital, 1 Radial Road, Pallikaranai, Chennai 600100, India.
authors: Sumana
authors: S
authors: Premkumar
authors: Vidyasagar Devaprasad
authors: VD
authors: Dedeepiya
authors: Hiroshi
authors: H
authors: Terunuma
authors: Rajappa
authors: R
authors: Senthilkumar
authors: Thangavelu
authors: T
authors: Srinivasan
authors: Helen C
authors: HC
authors: Reena
authors: Senthilkumar
authors: S
authors: Preethy
authors: Samuel J K
authors: SJ
authors: Abraham
references: Breast Cancer. 2011 Jan;18(1):64-7
references: 20354831
references: Discov Med. 2012 Aug;14(75):125-31
references: 22935209
references: Cancer. 1997 Jul 1;80(1):42-9
references: 9210707
references: Indian J Cancer. 2015 Jul-Sep;52(3):395-6
references: 26905149
references: Lancet. 2000 Sep 2;356(9232):802-7
references: 11022927
references: Clin Cancer Res. 2002 Jun;8(6):1767-71
references: 12060615
references: Br J Cancer. 2010 Aug 24;103(5):613-6
references: 20628380
references: Case Rep Oncol. 2012 Jan;5(1):114-8
references: 22666198
references: Anticancer Res. 2002 Jul-Aug;22(4):2461-4
references: 12174944
references: Gynecol Oncol. 2011 Jun 1;121(3):542-5
references: 21420157
references: Gynecol Oncol. 2006 Jul;102(1):74-9
references: 16406062