title: Crystalloid flush with backward unclamping may decrease post-reperfusion cardiac arrest and improve short-term graft function when compared to portal blood flush with forward unclamping during liver transplantation.
abstract: During liver transplant (LT), the release of vasoactive substances into the systemic circulation is associated with severe hemodynamic instability that is injurious to the recipient and/or the post-ischemic graft. Crystalloid flush with backward unclamping (CB) and portal blood flush with forward unclamping (PF) are two reperfusion methods to reduce reperfusion-related cardiovascular perturbations in our center. The primary aim of this study was to compare these two methods. After institutional review board (IRB) approval, cadaveric whole LT cases performed between 2003 and 2008 were reviewed. Patients were divided into two groups based on reperfusion methods: CB or PF. After background matching with propensity score, the effect of each method on post-operative graft function was assessed in detail. In our cohort of 478 patients, CB was used in 313 grafts and PF in 165. Thirty-day graft survival was lower, and risk of retransplantation was higher in PF. Multivariable model showed that CB is an independent factor to reduce primary non-function, cardiac arrest and improve 30-d graft survival. Also, the incidence of ischemic-type biliary lesions was significantly higher in the PF group. Reperfusion methods affect intraoperative hemodynamics and post-transplant outcome. CB allows for control over temperature and composition of the perfusate, perfusion pressure, and the rate of infusion.
authors: Division of Solid Organ Transplantation, Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL 33136, USA. kfukazawa@med.miami.edu
authors: Kyota
authors: K
authors: Fukazawa
authors: Seigo
authors: S
authors: Nishida
authors: Taizo
authors: T
authors: Hibi
authors: Ernesto A
authors: EA
authors: Pretto
mesh_terms: D000328:Adult; D000077324:Crystalloid Solutions; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival / Q000502:physiology*; D006323:Heart Arrest / Q000401:mortality / Q000517:prevention & control; D006439:Hemodynamics; D006801:Humans; D007552:Isotonic Solutions; D017093:Liver Failure / Q000150:complications* / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D015427:Reperfusion Injury / Q000401:mortality* / Q000517:prevention & control; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D000077324:Crystalloid Solutions; D007552:Isotonic Solutions
keywords: cardiac arrest; flush; graft function; liver transplant; portal