title: Role of the hippocampus and orbitofrontal cortex during the disambiguation of social cues in working memory.
abstract: Human social interactions are complex behaviors requiring the concerted effort of multiple neural systems to track and monitor the individuals around us. Cognitively, adjusting our behavior on the basis of changing social cues such as facial expressions relies on working memory and the ability to disambiguate, or separate, the representations of overlapping stimuli resulting from viewing the same individual with different facial expressions. We conducted an fMRI experiment examining the brain regions contributing to the encoding, maintenance, and retrieval of overlapping identity information during working memory using a delayed match-to-sample task. In the overlapping condition, two faces from the same individual with different facial expressions were presented at sample. In the nonoverlapping condition, the two sample faces were from two different individuals with different expressions. fMRI activity was assessed by contrasting the overlapping and nonoverlapping conditions at sample, delay, and test. The lateral orbitofrontal cortex showed increased fMRI signal in the overlapping condition in all three phases of the delayed match-to-sample task and increased functional connectivity with the hippocampus when encoding overlapping stimuli. The hippocampus showed increased fMRI signal at test. These data suggest that lateral orbitofrontal cortex helps encode and maintain representations of overlapping stimuli in working memory, whereas the orbitofrontal cortex and hippocampus contribute to the successful retrieval of overlapping stimuli. We suggest that the lateral orbitofrontal cortex and hippocampus play a role in encoding, maintaining, and retrieving social cues, especially when multiple interactions with an individual need to be disambiguated in a rapidly changing social context in order to make appropriate social responses.
authors: Center for Memory and Brain, Boston University, Boston, MA, 02215, USA, bross@bu.edu.
authors: Robert S
authors: RS
authors: Ross
authors: Matthew L
authors: ML
authors: LoPresti
authors: Karin
authors: K
authors: Schon
authors: Chantal E
authors: CE
authors: Stern
mesh_terms: D000293:Adolescent; D003463:Cues; D004193:Discrimination Learning / Q000502:physiology*; D005149:Facial Expression; D005260:Female; D006624:Hippocampus / Q000098:blood supply / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D010364:Pattern Recognition, Visual; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000098:blood supply / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D055815:Young Adult
chemical_list: D010100:Oxygen
references: Eur J Neurosci. 2013 Feb;37(4):668-78
references: 23167976
references: Hippocampus. 2001;11(4):337-46
references: 11530838
references: Brain Res. 2011 Nov 14;1423:53-66
references: 22000080
references: J Neurosci. 2006 Apr 26;26(17):4596-601
references: 16641239
references: J Neurosci. 2010 Dec 15;30(50):16868-75
references: 21159958
references: Neuroimage. 2012 Apr 2;60(2):1316-30
references: 22266411
references: Neuroimage. 2004 Oct;23(2):752-63
references: 15488425
references: Behav Neurosci. 1992 Oct;106(5):762-75
references: 1445656
references: J Neurosci. 2009 Jan 28;29(4):1052-960
references: 19176814
references: J Cogn Neurosci. 2004 Apr;16(3):463-78
references: 15072681
references: Brain Cogn. 2004 Jun;55(1):11-29
references: 15134840
references: Brain. 2003 Aug;126(Pt 8):1830-7
references: 12821528
references: Hippocampus. 2009 Sep;19(9):790-9
references: 19219919
references: J Neurosci. 2006 Aug 9;26(32):8352-9
references: 16899730
references: Neuroimage. 2008 Jan 15;39(2):857-72
references: 17950623
references: J Cogn Neurosci. 2005 Jul;17(7):994-1010
references: 16102232
references: J Neurosci Methods. 2002 Apr 15;115(2):137-43
references: 11992665
references: Hippocampus. 1995;5(6):511-33
references: 8646279
references: Neuroimage. 2003 Oct;20(2):1371-83
references: 14568506
references: J Neurosci. 2004 Dec 8;24(49):11088-97
references: 15590925
references: J Neurosci. 2002 Jul 1;22(13):5760-8
references: 12097529
references: J Neurosci. 2005 Oct 5;25(40):9112-23
references: 16207870
references: Cereb Cortex. 2007 Jul;17(7):1650-63
references: 16968868
references: J Cogn Neurosci. 2006 Jul;18(7):1087-97
references: 16839283
references: J Neurosci. 2009 Sep 23;29(38):11880-90
references: 19776274
references: Neuron. 2006 Feb 16;49(4):617-29
references: 16476669
references: Hippocampus. 2007;17(1):34-48
references: 17143905
references: J Neurosci. 2011 Feb 16;31(7):2706-11
references: 21325539
references: J Neurosci. 1996 Jul 1;16(13):4207-21
references: 8753882
references: Hippocampus. 2006;16(7):604-16
references: 16770797
references: J Neurosci. 2003 Sep 24;23(25):8771-80
references: 14507977
references: Neuropsychologia. 2003;41(3):341-56
references: 12457759
references: Cereb Cortex. 2009 Nov;19(11):2561-71
references: 19224975
references: J Neurosci. 2007 Aug 8;27(32):8517-24
references: 17687029
references: J Neurosci. 2005 Feb 9;25(6):1313-23
references: 15703385
references: J Neurosci. 2008 Aug 13;28(33):8338-43
references: 18701696
references: Cereb Cortex. 1996 Jan-Feb;6(1):39-49
references: 8670637
references: Neuroimage. 2000 May;11(5 Pt 1):380-91
references: 10806025
references: J Neurosci. 2010 May 26;30(21):7414-22
references: 20505108
references: Int J Psychophysiol. 2005 Jul;57(1):15-23
references: 15935259
references: J Neurosci. 2010 Oct 13;30(41):13624-9
references: 20943903
references: Neuropsychologia. 2007 Jan 7;45(1):124-43
references: 16797609
references: Learn Mem. 2003 Mar-Apr;10(2):129-40
references: 12663751
references: Philos Trans R Soc Lond B Biol Sci. 2005 Apr 29;360(1456):781-95
references: 15937012
references: Behav Brain Res. 2003 Nov 30;146(1-2):97-103
references: 14643463
references: Brain Res Cogn Brain Res. 2003 Jun;17(1):75-82
references: 12763194
references: Neuron. 2008 Oct 23;60(2):378-89
references: 18957228
references: J Comp Neurol. 2007 May 1;502(1):86-112
references: 17335041
references: Neuron. 2000 Sep;27(3):623-33
references: 11055443
references: J Comp Neurol. 2003 Jun 2;460(3):425-49
references: 12692859
references: J Neurosci. 2008 Apr 30;28(18):4818-22
references: 18448658
references: Eur J Neurosci. 2001 Aug;14(3):435-51
references: 11553294
references: Neuropsychologia. 1997 Jul;35(7):999-1015
references: 9226661
references: Brain. 2004 May;127(Pt 5):1108-26
references: 14985269
references: J Neurosci. 2006 May 10;26(19):5098-108
references: 16687501
references: Cereb Cortex. 2008 Sep;18(9):2141-57
references: 18245042
references: Hippocampus. 2013 Jun;23(6):467-75
references: 23504938
references: Cereb Cortex. 1996 Jul-Aug;6(4):571-84
references: 8670683
references: Nat Rev Neurosci. 2000 Oct;1(1):41-50
references: 11252767
references: J Neurosci. 2008 Apr 2;28(14):3718-28
references: 18385330
references: Neuron. 2010 Mar 25;65(6):927-39
references: 20346766
references: Neuropsychologia. 2008 Jan 31;46(2):614-23
references: 18023459
references: Neuron. 2001 Sep 13;31(5):865-73
references: 11567623
references: Cereb Cortex. 2000 Mar;10(3):220-42
references: 10731218