title: The role of pentraxin 3 as diagnostic value in classification of patients with heart failure.
abstract: OBJECTIVE
  Pentraxin 3 (PTX3) is a new inflammatory marker that is the prototype of the long pentraxin group, while C-reactive protein (CRP) is the short pentraxin group. The aim of the present study was to investigate the clinical significance of plasma PTX3 and CRP levels in heart failure (HF).
  
  
  METHODS
  The study included 22 male and 37 female patients with HF, and 23 healthy volunteers as the control group. Patients were divided into 4 groups (class I, II, III and IV) according to New York Heart Association functional class.
  
  
  RESULTS
  Plasma PTX3 and CRP levels were significantly elevated in HF patients compared to healthy controls. Comparing PTX3 levels in patient groups, statistically significant difference was found between class-I and class-II, class-III and class-IV patients (p=0.009, p=0.001, p<0.001, respectively). There was a positive correlation between PTX3 and CRP levels (r=0.369, p=0.004). In receiver-operating characteristic (ROC) curves, area under the curve (AUC) values for PTX3 and CRP were 0.928 (p=0.001) and 0.834 (p=0.001), respectively.
  
  
  CONCLUSIONS
  Plasma PTX3 levels are elevated in HF and might be used as diagnostic value in classification of patients with HF. It is still debated whether inflammation may be just a cause or a consequence of the disease. Therefore further work is needed to better understand in large populations of patients with HF.
authors: Umraniye Education and Research Hospital, Medical Biochemistry Laboratory, Istanbul, Turkey.
authors: Sermin
authors: S
authors: Duran
authors: Department of Medical Biochemistry, Goztepe Education and Research Hospital, University of Medeniyet, Istanbul, Turkey.
authors: Ilyas
authors: I
authors: Duran
authors: Dr. Lutfi Kırdar Kartal Training And Research Hospital, Medical Biochemistry Laboratory, Istanbul, Turkey.
authors: Fatma Asuman Orçun
authors: FAO
authors: Kaptanagası
authors: Department of Medical Biochemistry, Goztepe Education and Research Hospital, University of Medeniyet, Istanbul, Turkey.
authors: Filiz
authors: F
authors: Nartop
authors: Department of Internal Medicine, Goztepe Education and Research Hospital, University of Medeniyet, Istanbul, Turkey.
authors: Hilmi
authors: H
authors: Ciftci
authors: Kırklareli University, School of Health, Kırklareli, Turkey. Electronic address: gulcanguntas@gmail.com.
authors: Gulcan Guntas
authors: GG
authors: Korkmaz
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D006333:Heart Failure / Q000145:classification* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D012372:ROC Curve; D012680:Sensitivity and Specificity; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins
keywords: C-reactive protein; Heart failure; Left ventricular end-diastolic diameter; Left ventricular end-systolic diameter; Pentraxin 3