title: Light sensing in Aspergillus fumigatus highlights the case for establishing new models for fungal photobiology.
abstract: Microbes inhabit diverse environmental locations, and many species need to shift their physiology between different niches. To do this effectively requires the accurate sensing of and response to the environment. For pathogens, exposure to light is one major change between a free-living saprophyte lifestyle and causation of disease within the host. However, how light may act as a signal to influence pathogenesis, on the side of either the host or the pathogen, is poorly understood. Research during the last 2 decades has uncovered aspects about the machinery for light sensing in a small number of fungi. Now, Fuller et al. have initiated studies into the role that light and two photosensor homologs play in the behavior of the ubiquitous fungal pathogen Aspergillus fumigatus [K. K. Fuller, C. S. Ringelberg, J. J. Loros, and J. C. Dunlap, mBio 4(2):e00142-13, 2013, doi:10.1128/mBio.00142-13]. Light represses the germination of A. fumigatus spores and enhances resistance to ultraviolet light, oxidative stresses, and cell wall perturbations. The phenotypes of the strains with mutations in the LreA and FphA homologs revealed that these sensors control some, but not all, responses to light. Furthermore, interactions occur between blue and red light signaling pathways, as has been described for a related saprophytic species, Aspergillus nidulans. Genome-wide transcript analyses found that about 2.6% of genes increase or decrease their transcript levels in response to light. This use of A. fumigatus establishes common elements between model filamentous species and pathogenic species, underscoring the benefits of extending photobiology to new species of fungi.
authors: Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, Missouri, USA.
authors: Alexander
authors: A
authors: Idnurm
mesh_terms: D001232:Aspergillus fumigatus / Q000235:genetics* / Q000528:radiation effects*; D015966:Gene Expression Regulation, Fungal / Q000528:radiation effects*; D008027:Light; D013312:Stress, Physiological / Q000528:radiation effects*
references: mBio. 2011 Nov 22;2(6):
references: 22108383
references: Mol Biol Cell. 2008 Aug;19(8):3254-62
references: 18495868
references: Nat Protoc. 2007;2(4):811-21
references: 17446881
references: Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7095-100
references: 19380729
references: Curr Genet. 2013 May;59(1-2):55-62
references: 23385948
references: PLoS Biol. 2005 Apr;3(4):e95
references: 15760278
references: Curr Biol. 2008 Feb 26;18(4):255-9
references: 18291652
references: Fungal Genet Biol. 2010 Nov;47(11):893-9
references: 20466063
references: Curr Biol. 2005 Oct 25;15(20):1833-8
references: 16243030
references: PLoS Pathog. 2011 Jul;7(7):e1002113
references: 21829344
references: Genetics. 2011 Aug;188(4):809-22
references: 21624998
references: PLoS Pathog. 2011 Jul;7(7):e1002145
references: 21811407
references: Eukaryot Cell. 2008 Jul;7(7):1227-30
references: 18503005
references: mBio. 2013 Mar 26;4(2):
references: 23532976