title: Medial temporal lobe volume predicts elders' everyday memory.
abstract: Deficits in memory for everyday activities are common complaints among healthy and demented older adults. The medial temporal lobes and dorsolateral prefrontal cortex are both affected by aging and early-stage Alzheimer's disease, and are known to influence performance on laboratory memory tasks. We investigated whether the volume of these structures predicts everyday memory. Cognitively healthy older adults and older adults with mild Alzheimer's-type dementia watched movies of everyday activities and completed memory tests on the activities. Structural MRI was used to measure brain volume. Medial temporal but not prefrontal volume strongly predicted subsequent memory. Everyday memory depends on segmenting activity into discrete events during perception, and medial temporal volume partially accounted for the relationship between performance on the memory tests and performance on an event-segmentation task. The everyday-memory measures used in this study involve retrieval of episodic and semantic information as well as working memory updating. Thus, the current findings suggest that during perception, the medial temporal lobes support the construction of event representations that determine subsequent memory.
authors: Washington University in St. Louis, MO 63130, USA. hroth@artsci.wustl.edu
authors: Heather R
authors: HR
authors: Bailey
authors: Jeffrey M
authors: JM
authors: Zacks
authors: David Z
authors: DZ
authors: Hambrick
authors: Rose T
authors: RT
authors: Zacks
authors: Denise
authors: D
authors: Head
authors: Christopher A
authors: CA
authors: Kurby
authors: Jesse Q
authors: JQ
authors: Sargent
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology; D001931:Brain Mapping; D016022:Case-Control Studies; D018728:Entorhinal Cortex / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D008569:Memory Disorders / Q000473:pathology* / Q000503:physiopathology; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D009929:Organ Size; D020534:Parahippocampal Gyrus / Q000473:pathology; D017397:Prefrontal Cortex / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology*
keywords: aging; cognitive neuroscience; memory; perception
references: Neurobiol Aging. 2010 Jul;31(7):1089-98
references: 18809228
references: Psychol Sci. 2010 Aug;21(8):1123-33
references: 20624934
references: J Cogn Neurosci. 2011 May;23(5):1052-64
references: 20521850
references: Psychol Aging. 1990 Dec;5(4):482-90
references: 2278670
references: Brain. 2005 Apr;128(Pt 4):773-87
references: 15705615
references: J Cogn Neurosci. 2007 Oct;19(10):1690-705
references: 17854282
references: Trends Neurosci. 2009 Jun;32(6):321-8
references: 19446348
references: Trends Cogn Sci. 2009 Mar;13(3):103-9
references: 19223228
references: Neurology. 1996 Mar;46(3):692-700
references: 8618669
references: Behav Brain Sci. 2001 Feb;24(1):87-114; discussion 114-85
references: 11515286
references: Neuroimage. 2006 Jul 1;31(3):968-80
references: 16530430
references: Psychol Bull. 2007 Mar;133(2):273-93
references: 17338600
references: Neuron. 1995 Mar;14(3):477-85
references: 7695894
references: Neurobiol Aging. 2009 Mar;30(3):432-40
references: 17869384
references: Neuropsychology. 1998 Jan;12(1):95-114
references: 9460738
references: Psychol Med. 1989 Nov;19(4):1015-22
references: 2594878
references: Psychol Bull. 2007 Nov;133(6):1038-66
references: 17967093
references: Psychol Aging. 1992 Sep;7(3):376-88
references: 1388858
references: Learn Mem. 2011 Dec 16;19(1):15-25
references: 22180053
references: J Neurosci. 2006 Aug 9;26(32):8352-9
references: 16899730
references: Science. 2008 Feb 29;319(5867):1264-7
references: 18309087
references: Neurology. 2009 Aug 11;73(6):457-65
references: 19667321
references: Mem Cognit. 2011 Jan;39(1):75-91
references: 21264613
references: Psychol Aging. 1992 Mar;7(1):72-82
references: 1558708
references: Ann N Y Acad Sci. 1995 Dec 15;769:337-68
references: 8595036
references: Neuroimage. 2004 Oct;23(2):724-38
references: 15488422
references: Acta Psychol (Amst). 1967;26(2):107-29
references: 6037305
references: Arch Neurol. 1993 Sep;50(9):967-73
references: 8363451
references: Behav Res Methods Instrum Comput. 2003 Feb;35(1):32-48
references: 12723778
references: Neurology. 1993 Nov;43(11):2412-4
references: 8232972
references: Psychol Aging. 2006 Sep;21(3):466-82
references: 16953710
references: Annu Rev Neurosci. 2007;30:123-52
references: 17417939
references: Neuroimage. 2012 Aug 15;62(2):774-81
references: 22248573
references: Science. 2008 Mar 21;319(5870):1640-2
references: 18356518
references: Ann Neurol. 2004 Mar;55(3):306-19
references: 14991808