title: Cryptosporioptide: a bioactive polyketide produced by an endophytic fungus Cryptosporiopsis sp.
abstract: An antibiotic polyketide, Cryptosporioptide (1) was isolated from the culture extract of the endophytic fungus Cryptosporiopsis sp. The structure of Cryptosporioptide has been established with the help of 1D ((1)H, (13)C), 2D NMR (HSQC, HMBC, COSY, NOESY) techniques and mass spectrometry (FABMS, HRFABMS). The absolute configuration was established by means of electronic circular dichroism (ECD). Cryptosporioptide exhibited both lipoxygenase inhibitory and anti-Bacillus megaterium activities.
authors: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan. drsaleem_kr@yahoo.com
authors: Muhammad
authors: M
authors: Saleem
authors: Muhammad Imran
authors: MI
authors: Tousif
authors: Naheed
authors: N
authors: Riaz
authors: Ishtiaq
authors: I
authors: Ahmed
authors: Barbara
authors: B
authors: Schulz
authors: Muhammad
authors: M
authors: Ashraf
authors: Rumana
authors: R
authors: Nasar
authors: Gennaro
authors: G
authors: Pescitelli
authors: Hidayat
authors: H
authors: Hussain
authors: Abdul
authors: A
authors: Jabbar
authors: Nusrat
authors: N
authors: Shafiq
authors: Karsten
authors: K
authors: Krohn
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001410:Bacillus megaterium / Q000187:drug effects*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008084:Lipoxygenase / Q000378:metabolism*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D016859:Lipoxygenase Inhibitors; D061065:Polyketides; C586992:cryptosporioptide; D008084:Lipoxygenase
keywords: Anti-Bacillus megaterium; Cryptosporiopsis sp.; Endophytic fungus; Lipoxygenase inhibition; Novel polyketide; TDDFT CD calculations