title: The atrial natriuretic peptide genetic variant rs5068 is associated with a favorable cardiometabolic phenotype in a Mediterranean population.
abstract: OBJECTIVE
  We hypothesized that the minor allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with a favorable cardiometabolic phenotype in a general Mediterranean population.
  
  
  METHODS
  We genotyped a random sample of the residents of Ventimiglia di Sicilia, Sicily, for rs5068.
  
  
  RESULTS
  Genotype frequencies of rs5068 are AA, 93.5%; AG, 6.4%; and GG, 0.1%. All subsequent analyses are AA versus AG+GG. After adjusting for age and sex, the minor G allele is associated with lower BMI (estimate [SE]: -1.7 kg/m(2) [0.8], P = 0.04). In the AG+GG group, males with HDL cholesterol levels <40 mg/dL are less frequent (P = 0.05) and obesity tends to be less prevalent (P = 0.07). Importantly, the G allele is associated with a lower prevalence of metabolic syndrome (P = 0.02). After adjusting for BMI, the above associations were attenuated. Independently of age, sex, and BMI, the minor allele is also associated with lower systolic blood pressure (-6.0 mmHg [2.5], P = 0.02) and lower prevalence of hypertension (odds ratio 0.41 [95% CI 0.20-0.83], P = 0.01).
  
  
  CONCLUSIONS
  The association between the minor allele of rs5068 and a favorable cardiometabolic phenotype that we previously reported in a U.S. population is now replicated in a Mediterranean population in which the G allele of rs5068 is associated with lower blood pressure, BMI, and prevalence of hypertension and metabolic syndrome. These findings may lead to a diagnostic strategy to assess cardiometabolic risk and lay the foundation for the future development of an ANP or ANP-like therapy for metabolic syndrome.
authors: Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA. cannone.valentina@mayo.edu
authors: Valentina
authors: V
authors: Cannone
authors: Angelo Baldassare
authors: AB
authors: Cefalu'
authors: Davide
authors: D
authors: Noto
authors: Christopher G
authors: CG
authors: Scott
authors: Kent R
authors: KR
authors: Bailey
authors: Giovanni
authors: G
authors: Cavera
authors: Michele
authors: M
authors: Pagano
authors: Michelangelo
authors: M
authors: Sapienza
authors: Maurizio R
authors: MR
authors: Averna
authors: John C
authors: JC
authors: Burnett
mesh_terms: D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000235:genetics; D010641:Phenotype
chemical_list: D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor
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