title: Novel substituted heteroaromatic piperazine and piperidine derivatives as inhibitors of human enterovirus 71 and coxsackievirus a16.
abstract: A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackievirus A16 with low cytotoxicity.
authors: Key Laboratory of Structure-Based Drug Design and Discovery of the Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, Liangning, China.
authors: Xian
authors: X
authors: Zhang
authors: Hongliang
authors: H
authors: Wang
authors: Yuhuan
authors: Y
authors: Li
authors: Ruiyuan
authors: R
authors: Cao
authors: Wu
authors: W
authors: Zhong
authors: Zhibing
authors: Z
authors: Zheng
authors: Gang
authors: G
authors: Wang
authors: Junhai
authors: J
authors: Xiao
authors: Song
authors: S
authors: Li
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D036022:Capsid Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D002522:Chlorocebus aethiops; D029821:Enterovirus A, Human / Q000737:chemistry / Q000254:growth & development* / Q000378:metabolism; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D036022:Capsid Proteins; D010879:Piperazines; D010880:Piperidines
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