title: Telephone based cognitive behavioral therapy targeting major depression among urban dwelling, low income people living with HIV/AIDS: results of a randomized controlled trial.
abstract: This pilot randomized controlled trial evaluated a previously developed manualized telephone based cognitive behavioral therapy (T-CBT) intervention compared to face-to-face (f2f) therapy among low-income, urban dwelling HIV infected depressed individuals. The primary outcome was the reduction of depressive symptoms as measured by the Hamliton rating scale for depression scale. The secondary outcome was adherence to HAART as measured by random telephone based pill counts. Outcome measures were collected by trained research assistants masked to treatment allocation. Analysis was based on intention-to-treat. Thirty-four participants met eligibility criteria and were randomly assigned to receive T-CBT (n = 16) or f2f (n = 18). There was no statistically significant difference in depression treatment outcomes comparing f2f to T-CBT. Within group evaluation demonstrated that both the T-CBT and the f2f psychotherapy groups resulted in significant reductions in depressive symptoms. Those who received the T-CBT were significantly more likely to maintain their adherence to antiretroviral medication compared to the f2f treatment. None of the participants discontinued treatment due to adverse events. T-CBT can be delivered to low-income, urban dwelling HIV infected depressed individuals resulting in significant reductions in depression symptoms and improved adherence to antiretroviral medication.
  
  
  BACKGROUND
  Clinical Trial.gov identifier: NCT01055158.
authors: Department of Psychiatry, Division of Services Research, University of Maryland School of Medicine, 737 West Lombard St., Room 516, Baltimore, MD, 21212, USA, shimelho@psych.umaryland.edu.
authors: Seth
authors: S
authors: Himelhoch
authors: Deborah
authors: D
authors: Medoff
authors: Jennifer
authors: J
authors: Maxfield
authors: Sarah
authors: S
authors: Dihmes
authors: Lisa
authors: L
authors: Dixon
authors: Charles
authors: C
authors: Robinson
authors: Wendy
authors: W
authors: Potts
authors: David C
authors: DC
authors: Mohr
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015928:Cognitive Behavioral Therapy; D003865:Major Depressive Disorder / Q000208:ethnology / Q000209:etiology / Q000628:therapy*; D004522:Educational Status; D005240:Feasibility Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000523:psychology* / Q000628:therapy; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D010349:Patient Compliance; D017060:Patient Satisfaction; D010865:Pilot Projects; D011203:Poverty; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D013689:Telephone; D016896:Treatment Outcome; D014505:Urban Population
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