title: Successful combination therapy with corticosteroids, biweekly intravenous pulse cyclophosphamide and cyclosporin A for acute interstitial pneumonia in patients with dermatomyositis : report of three cases.
abstract: We report three patients with dermatomyositis (DM) complicated with acute interstitial pneumonia (AIP). All of them complained of fever and acutely worsening dyspnea and were treated immediately by combination therapies with pulse therapy with methylprednisone (mPSL) followed by corticosteroids, biweekly intravenous pulse cyclophosphamide (IVCY) and cyclosporine A (CSA). They recovered rapidly soon after an initiation of this combination regimen. Early intervention with aggressive combination therapy is life-saving for the treatment of AIP in patients with DM.
authors: Center for Rheumatology and Joint Surgery, Kawakita General Hospital.
authors: Akitake
authors: A
authors: Suzuki
authors: Norikazu
authors: N
authors: Shoji
authors: Eigo
authors: E
authors: Kikuchi
authors: Kazuaki
authors: K
authors: Uekubo
authors: Naoko
authors: N
authors: Aoki
authors: Yui
authors: Y
authors: Sonoda
authors: Hideyuki
authors: H
authors: Torigai
authors: Hiroyuki
authors: H
authors: Yamashita
authors: Kentaro
authors: K
authors: Fujita
authors: Takahiro
authors: T
authors: Okai
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000368:Aged; D003520:Cyclophosphamide / Q000008:administration & dosage*; D016572:Cyclosporine / Q000008:administration & dosage*; D003882:Dermatomyositis / Q000150:complications*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D020551:Pulse Therapy, Drug
chemical_list: D000305:Adrenal Cortex Hormones; D016572:Cyclosporine; D003520:Cyclophosphamide