title: [Influence of water fluoride exposure on sex hormone binding globulin and testosterone in adult male].
abstract: OBJECTIVE
  To explore the influence of water fluoride exposure on sex hormone binding globulin (SHBG) and testosterone in adult male.
  
  
  METHODS
  Cross-sectional study was conducted in three villages of Tongxu county including high fluoride group (HFG), defluoridation project group (DFPG) and control group (CG) based on the fluoride concentration in drinking water. Adult male who were born and raised in the village and aged 18 - 50 years old were recruited using cluster sampling. Fasting blood and morning urine samples were collected. The fluoride levels in drinking water and urine were detected by fluoride-ion selective electrode method. Serum SHBG level was determined using enzyme-linked immunosorbent assay (ELISA). The chemical luminescence immune analysis method was used to detect serum testosterone content.
  
  
  RESULTS
  Serum SHBG level was 47.85 nmol/L in CG, 31.37 nmol/L in DFPG and 24.52 nmol/L in HFG respectively. There were significant difference among of three groups (P < 0.05). Serum testosterone level was 3.69 ng/ml in CG, 4.61 ng/ml in DFPG and 4.83 ng/ml in HFG respectively. Serum testosterone level in HFG was significantly higher than that in CG (P < 0.05). Serum SHBG level in HFG has positive correlation with serum testosterone (r = 0.230, P = 0.049), which has not been observed in DFPG and CG.
  
  
  CONCLUSIONS
  Long-time fluorine exposure may affect serum SHBG and testosterone level in adult male.
authors: Department of Environmental Health, College of Public Health in Zhengzhou University, Zhengzhou 450001, China. zhoutong0273@126.com
authors: Tong
authors: T
authors: Zhou
authors: Rupu
authors: R
authors: Yang
authors: Shihong
authors: S
authors: Li
authors: Guoqing
authors: G
authors: Zheng
authors: Yu
authors: Y
authors: Xi
authors: Xuemin
authors: X
authors: Cheng
authors: Jiaxiang
authors: J
authors: Hou
authors: Liuxin
authors: L
authors: Cui
authors: Yue
authors: Y
authors: Ba
mesh_terms: D000293:Adolescent; D000328:Adult; D000727:Androgen-Binding Protein / Q000097:blood; D004305:Dose-Response Relationship, Drug; D060766:Drinking Water / Q000032:analysis*; D004781:Environmental Exposure / Q000009:adverse effects*; D005459:Fluorides / Q000009:adverse effects* / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013739:Testosterone / Q000097:blood*; D055815:Young Adult
chemical_list: D000727:Androgen-Binding Protein; D060766:Drinking Water; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D005459:Fluorides