title: Bithorax-complex genes sculpt the pattern of leucokinergic neurons in the Drosophila central nervous system.
abstract: Although the Hox genes are the main factors involved in the generation of diversity along the anterior/posterior body axis of segmented organisms, it is still largely unknown how these genes act in single cells to determine specific traits at precise developmental stages. The aim of this study was to understand the mechanisms by which Hox genes of the Bithorax complex (Bx-C) of Drosophila act to define segmental differences in the ventral nerve cord of the central nervous system. To achieve this, we have focused on the specification of the leucokinin-expressing neurons. We find that these neurons are specified from the same progenitor neuroblast at two different developmental stages: embryonic and larval neurogenesis. We show that genes of the Bx-C acted in postmitotic cells to specify the segment-specific appearance of leucokinergic cells in the larval and adult ventral nerve cord.
authors: Centro de Biología Molecular-Severo Ochoa (CSIC-UAM), c/Nicolas Cabrera 1,Universidad Autónoma, 28049 Madrid, Spain.
authors: Alicia
authors: A
authors: Estacio-Gómez
authors: Marta
authors: M
authors: Moris-Sanz
authors: Anne-Kathrin
authors: AK
authors: Schäfer
authors: Daniel
authors: D
authors: Perea
authors: Pilar
authors: P
authors: Herrero
authors: Fernando J
authors: FJ
authors: Díaz-Benjumea
mesh_terms: D000818:Animals; D019521:Body Patterning; D019070:Cell Lineage; D002490:Central Nervous System / Q000196:embryology / Q000378:metabolism; D003433:Crosses, Genetic; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D005838:Genotype; D018398:Homeodomain Proteins / Q000378:metabolism*; D007150:Immunohistochemistry; D009420:Nervous System / Q000196:embryology*; D009479:Neuropeptides / Q000378:metabolism; D010641:Phenotype; D013234:Stem Cells / Q000166:cytology; D013997:Time Factors
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D009479:Neuropeptides; C088629:leucokinin 1