title: Diffusion tensor magnetic resonance histology reveals microstructural changes in the developing rat brain.
abstract: The postnatal period is a remarkably dynamic phase of brain growth and development characterized by large-scale macrostructural changes, as well as dramatic microstructural changes, including myelination and cortical layering. This crucial period of neurodevelopment is uniquely susceptible to a wide variety of insults that may lead to neurologic disease. MRI is an important tool for studying both normal and abnormal neurodevelopmental changes, and quantitative imaging strategies like diffusion tensor imaging (DTI) allow visualization of many of the complex microstructural changes that occur during postnatal life. Diffusion tensor magnetic resonance histology (DT-MRH) provides particularly unique insight into cytoarchitectural changes in the developing brain. In this study, we used DT-MRH to track microstructural changes in the rat brain throughout normal postnatal neurodevelopment. We provide examples of diffusion tensor parameter changes in both white matter and gray matter structures, and correlate these changes with changes in cytoarchitecture. Finally, we provide a comprehensive database of image sets as a foundation for future studies using DT-MRH to characterize abnormal neurodevelopment in rodent models of neurodevelopmental disease.
authors: Center for In Vivo Microscopy, Department of Radiology, Box 3302 Duke University Medical Center, Durham, NC 27710, USA.
authors: Evan
authors: E
authors: Calabrese
authors: G Allan
authors: GA
authors: Johnson
mesh_terms: D000375:Aging / Q000473:pathology* / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D008297:Male; D009415:Nerve Net / Q000033:anatomy & histology* / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
references: J Biophys Biochem Cytol. 1956 Nov 25;2(6):777-84
references: 13398444
references: Autism Res. 2011 Oct;4(5):368-76
references: 21882360
references: Neuropsychol Rev. 2011 Jun;21(2):133-47
references: 21347880
references: Front Neuroinform. 2012 Mar 23;6:6
references: 22470335
references: Conf Proc IEEE Eng Med Biol Soc. 2006;2006:2252-5
references: 17946946
references: Neuroimage. 2007 Aug 1;37(1):82-9
references: 17574443
references: Magn Reson Med. 2001 Dec;46(6):1174-88
references: 11746585
references: Cereb Cortex. 2005 May;15(5):639-45
references: 15342433
references: AJNR Am J Neuroradiol. 2009 Nov;30(10):1907-13
references: 19749219
references: Methods Mol Biol. 1999;117:145-58
references: 10327404
references: J Neurosci. 1992 Dec;12(12):4890-7
references: 1281497
references: NMR Biomed. 2003 Apr;16(2):77-81
references: 12730948
references: AJNR Am J Neuroradiol. 2008 Apr;29(4):632-41
references: 18339720
references: Neuroimage. 2005 Jul 15;26(4):1042-51
references: 15961044
references: J Neurol Sci. 1969 Jan-Feb;8(1):49-60
references: 5790372
references: Annu Rev Neurosci. 1994;17:185-218
references: 8210173
references: J Neurosci Res. 2000 Aug 15;61(4):357-63
references: 10931521
references: Neuroimage. 2013 May 1;71:196-206
references: 23353030
references: Neuroimage. 2006 Sep;32(3):1243-9
references: 16861009
references: Neuropsychol Rev. 2011 Jun;21(2):167-85
references: 21445552
references: J Cogn Neurosci. 2004 Sep;16(7):1227-33
references: 15453975
references: J Neurosci Res. 2008 May 15;86(7):1520-8
references: 18189320
references: J Comp Neurol. 1976 Aug 1;168(3):313-43
references: 950383
references: Neuroimage. 2011 Jan 1;54(1):80-9
references: 20656042
references: J Magn Reson B. 1996 Jun;111(3):209-19
references: 8661285
references: Magn Reson Med. 2001 May;45(5):770-80
references: 11323803
references: Neuroimage. 2009 Feb 1;44(3):611-9
references: 19027864
references: J Comp Neurol. 1972 May;145(1):61-83
references: 4624784
references: Magn Reson Med. 2006 Aug;56(2):411-21
references: 16788917
references: NMR Biomed. 2007 Jun;20(4):413-21
references: 17120295
references: J Neuropathol Exp Neurol. 1996 Jul;55(7):758-73
references: 8965092
references: Acad Radiol. 2008 Nov;15(11):1360-75
references: 18995188
references: Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18465-70
references: 22025710
references: Proc Natl Acad Sci U S A. 2005 May 10;102(19):6978-83
references: 15860588
references: Magn Reson Med. 2001 Jul;46(1):18-23
references: 11443706
references: Nat Neurosci. 2004 Feb;7(2):136-44
references: 14703572
references: AJNR Am J Neuroradiol. 2006 Sep;27(8):1776-81
references: 16971635
references: Neuroimage. 2011 Jun 1;56(3):1235-43
references: 21419226
references: Pediatr Rehabil. 2004 Jul-Sep;7(3):165-71
references: 15204568
references: Cereb Cortex. 2007 Nov;17(11):2609-17
references: 17259644
references: J Comput Assist Tomogr. 2001 Sep-Oct;25(5):805-16
references: 11584245
references: Neuroimage. 2013 Feb 15;67:375-84
references: 23246176
references: Magn Reson Med. 2005 Jun;53(6):1447-51
references: 15906292
references: Neuroscience. 2005;135(3):815-27
references: 16154281
references: NMR Biomed. 2007 May;20(3):375-82
references: 17451176
references: Neuroimage. 2007 Jul 15;36(4):1123-38
references: 17532649
references: Radiology. 2002 Mar;222(3):789-93
references: 11867802
references: NMR Biomed. 1995 Nov-Dec;8(7-8):333-44
references: 8739270