title: Arterial stiffness and walk time in patients with end-stage renal disease.
abstract: BACKGROUND
  End-stage renal disease patients experience increased prevalence of cardiovascular disease. Heart-artery interaction may be shifted, impacting blood pressure lability, and exercise tolerance. The coupling ratio consists of the ratio of indexed arterial elastance (EaI, arterial load) to ElvI, a measure of cardiac contractility or stiffness. Our purpose was to explore the relationship between elastances and functional capacity. We hypothesized that arterial stiffness (central pulse wave velocity, PWV) and elastances would be correlated to shuttle walk time.
  
  
  METHODS
  We used applanation tonometry, ultrasonography, and a shuttle walk test to evaluate our hypothesis. Spearman's correlations were used to assess relationships between variables. Block regression was also performed.
  
  
  RESULTS
  Forty-two subjects on maintenance hemodialysis participated. Average age=44±5 years, body surface area=2.01 kg/m(2). Mean EaI=4.45 and mean ElvI=6.89; the coupling ratio=0.82. Mean aortic pulse pressure=51 mmHg and PWV=9.6 m/s. PWV(r=-0.385) and EaI (r=-0.424) were significantly and inversely related to walking time while stroke volume index (SVI) was positively correlated to shuttle walk time (r=0.337), p<0.05 for all.
  
  
  CONCLUSIONS
  We conclude that, like other clinical populations, both arterial and heart function predict walking ability and represent potential targets for intervention; arterial stiffness and SVI are strongly related to shuttle walk time in patients with ESRD.
authors: University of Illinois at Chicago, Chicago, IL, USA. lane14@uic.edu
authors: Abbi D
authors: AD
authors: Lane
authors: Pei-Tzu
authors: PT
authors: Wu
authors: Brandon
authors: B
authors: Kistler
authors: Peter
authors: P
authors: Fitschen
authors: Emily
authors: E
authors: Tomayko
authors: Jin-Hee
authors: JH
authors: Jeong
authors: Hae Ryung
authors: HR
authors: Chung
authors: Huimin
authors: H
authors: Yan
authors: Sushant M
authors: SM
authors: Ranadive
authors: Shane
authors: S
authors: Phillips
authors: Bo
authors: B
authors: Fernhall
authors: Kenneth
authors: K
authors: Wilund
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D001794:Blood Pressure / Q000502:physiology; D048909:Diabetes Complications / Q000503:physiopathology; D004548:Elasticity; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011674:Pulse; D012044:Regression Analysis; D006435:Renal Dialysis; D059289:Vascular Stiffness / Q000502:physiology*; D016138:Walking / Q000502:physiology*
references: Ann Biomed Eng. 1984;12(2):119-34
references: 6439084
references: N Engl J Med. 1990 May 31;322(22):1561-6
references: 2139921
references: Nephrol Dial Transplant. 2002;17 Suppl 1:29-36
references: 11812909
references: Am J Hypertens. 2002 May;15(5):445-52
references: 12022247
references: Clin Exp Pharmacol Physiol. 2009 Apr;36(4):413-8
references: 19018798
references: Pediatr Res. 1997 Sep;42(3):273-81
references: 9284265
references: J Hypertens. 1994 May;12(5):591-600
references: 7930560
references: Heart. 2008 Aug;94(8):1038-43
references: 18308865
references: J Am Soc Echocardiogr. 2009 Nov;22(11):1239-45
references: 19783121
references: Eur Heart J. 2006 May;27(10):1245-50
references: 16611670
references: Heart Fail Rev. 2002 Jan;7(1):51-62
references: 11790922
references: Eur Heart J. 2010 Oct;31(19):2338-50
references: 20530030
references: Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H349-58
references: 22003052
references: Diab Vasc Dis Res. 2010 Jul;7(3):216-24
references: 20605853
references: Eur J Heart Fail. 2011 Dec;13(12):1296-304
references: 21979991
references: Am Heart J. 1993 Jun;125(6):1659-66
references: 8498308
references: J Physiother. 2012;58(2):130
references: 22613246
references: Eur J Echocardiogr. 2009 Jan;10(1):36-43
references: 18799479
references: Hypertension. 2005 Jul;46(1):185-93
references: 15911741
references: J Am Coll Cardiol. 2011 Jul 12;58(3):265-74
references: 21737017
references: Curr Opin Nephrol Hypertens. 2006 Mar;15(2):105-10
references: 16481874
references: J Appl Physiol (1985). 2008 Oct;105(4):1342-51
references: 18617626
references: Nephrol Nurs J. 2011 Mar-Apr;38(2):139-47; quiz 148
references: 21520692
references: Nephron. 1994;66(2):125-8
references: 8139729
references: J Am Soc Echocardiogr. 2009 Nov;22(11):1246-8
references: 19883874
references: Am J Physiol. 1993 May;264(5 Pt 2):H1629-33
references: 8098914
references: Atherosclerosis. 2007 Apr;191(2):384-90
references: 16730015
references: Diabetes Care. 2011 Oct;34(10):2174-9
references: 21873560
references: J Am Coll Cardiol. 2010 Sep 7;56(11):845-54
references: 20813282
references: Am J Kidney Dis. 2010 Jan;55(1):88-99
references: 19932545
references: Nat Immunol. 2009 Jul;10(7):778-85
references: 19483719
references: Am J Hypertens. 2008 Oct;21(10):1100-6
references: 18719622
references: Am J Physiol. 1991 Jun;260(6 Pt 2):H1870-7
references: 1905490
references: Circulation. 1977 Apr;55(4):613-8
references: 138494
references: Adv Chronic Kidney Dis. 2009 Nov;16(6):437-48
references: 19801134
references: Int J Cardiovasc Imaging. 2010 Feb;26(2):151-9
references: 19823943
references: J Hypertens. 2008 May;26(5):1037-42
references: 18398348
references: Circ J. 2009 Jan;73(1):167-73
references: 19039192
references: Nephrol Dial Transplant. 1998 Feb;13(2):250-3
references: 9509430
references: Dtsch Med Wochenschr. 2008 Mar;133(12):586-90
references: 18335390