title: Influence of coffee brew in metabolic syndrome and type 2 diabetes.
abstract: This study aimed to evaluate the effect of coffee drinking on clinical markers of diabetes and metabolic syndrome in Zucker rats. Diabetic Zucker rats with metabolic syndrome and control Zucker rats were used for in vivo tests. The animals received daily doses of coffee drink by gavage for 30 days. After the treatment, the levels of glucose, triglycerides, total cholesterol and fractions, creatinine, uric acid, activity of aspartate aminotransferase and alanine aminotransferase were evaluated. Urea and creatinine levels were also analyzed in urine. By collaborating in the modulation of the metabolic syndrome and diabetes mellitus type 2, coffee drink helped in reducing serum glucose, total cholesterol and triglycerides. The results demonstrate that treatment with roasted coffee drink, because of its hypoglycemic and hypolipidemic effect, is efficient in the protection of animals with metabolic syndrome and diabetes mellitus type 2.
authors: Fluminense Federal Institute, Bom Jesus do Itabapoana, RJ, Brazil. sheilanutri@yahoo.com.br
authors: Sheila Andrade
authors: SA
authors: Abrahão
authors: Rosemary Gualberto Fonseca Alvarenga
authors: RG
authors: Pereira
authors: Raimundo Vicente
authors: RV
authors: de Sousa
authors: Adriene Ribeiro
authors: AR
authors: Lima
authors: Gabriela Previatti
authors: GP
authors: Crema
authors: Bianca Sacramento
authors: BS
authors: Barros
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003069:Coffee; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000178:diet therapy*; D051381:Rats; D011924:Rats, Zucker; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003069:Coffee; D007004:Hypoglycemic Agents; D014280:Triglycerides; D014508:Urea; D002784:Cholesterol; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
references: Plant Foods Hum Nutr. 2011 Jun;66(2):114-21
references: 21523414
references: Plant Foods Hum Nutr. 2012 Mar;67(1):82-7
references: 22173821
references: J Nutr Biochem. 2002 Dec;13(12):717-726
references: 12550056
references: Nephrol Dial Transplant. 2002 Jul;17(7):1157-9
references: 12105233
references: J Clin Invest. 2004 Jul;114(2):147-52
references: 15254578
references: Ann Intern Med. 2004 Jan 6;140(1):1-8
references: 14706966
references: Am J Clin Nutr. 1995 Jan;61(1):149-54
references: 7825527
references: Diabetes. 2001 Oct;50(10):2349-54
references: 11574419
references: Plant Foods Hum Nutr. 2012 Mar;67(1):64-70
references: 22210166
references: Br J Pharmacol. 1998 Oct;125(4):767-70
references: 9831913
references: Food Chem Toxicol. 2002 Aug;40(8):1155-63
references: 12067578
references: JAMA. 2004 Mar 10;291(10):1213-9
references: 15010442
references: Plant Foods Hum Nutr. 2012 Sep;67(3):277-82
references: 22766993
references: Plant Foods Hum Nutr. 2008 Dec;63(4):176-82
references: 18726160