title: C1 inhibitor concentrate treatment of multiple laryngeal attacks in a 53-year-old woman with hereditary angioedema.
abstract: This report describes a woman who experienced a high number of laryngeal hereditary angioedema (HAE) attacks during her participation in the IMPACT2 clinical trial of C1-INH concentrate. A 53-year-old caucasian female with a 31-year history of type 1 HAE experienced 16 laryngeal HAE attacks between 3 August 2006 and 23 February 2010, 15 of which were severe. All laryngeal attacks were successfully treated with C1-INH 20 U/kg, with a median onset of relief of 14 min and median time to complete resolution of symptoms of 20 h, and no need for redosing. The reliable success of C1-INH for these potentially fatal events is reassuring for both patients and prescribers.
authors: Family First Medical Center, 3614 Washington Pkwy, Idaho Falls, ID 83404, USA. packer@familyfirstif.com
authors: Flint R
authors: FR
authors: Packer
mesh_terms: D003174:Complement C1 Inactivator Proteins / Q000378:metabolism; D050718:Complement C1 Inhibitor Protein / Q000008:administration & dosage*; D005260:Female; D056829:Hereditary Angioedema Types I and II / Q000188:drug therapy*; D006801:Humans; D007275:Injections, Intravenous; D007818:Laryngeal Diseases / Q000188:drug therapy*; D008875:Middle Aged; D004364:Pharmaceutical Preparations; D016896:Treatment Outcome
chemical_list: D003174:Complement C1 Inactivator Proteins; D050718:Complement C1 Inhibitor Protein; D004364:Pharmaceutical Preparations; C469952:SERPING1 protein, human