title: Expertise modulates local regional homogeneity of spontaneous brain activity in the resting brain: an fMRI study using the model of skilled acupuncturists.
abstract: Studies on training/expertise-related effects on human brain in context of neuroplasticity have revealed that plastic changes modulate not only task activations but also patterns and strength of internetworks and intranetworks functional connectivity in the resting state. Much has known about plastic changes in resting state on global level; however, how training/expertise-related effect affects patterns of local spontaneous activity in resting brain remains elusive. We investigated the homogeneity of local blood oxygen level-dependent fluctuations in the resting state using a regional homogeneity (ReHo) analysis among 16 acupuncturists and 16 matched nonacupuncturists (NA). To prove acupuncturists' expertise, we used a series of psychophysical tests. Our results demonstrated that, acupuncturists significantly outperformed NA in tactile-motor and emotional regulation domain and the acupuncturist group showed increased coherence in local BOLD signal fluctuations in the left primary motor cortex (MI), the left primary somatosensory cortex (SI) and the left ventral medial prefrontal cortex/orbitofrontal cortex (VMPFC/OFC). Regression analysis displayed that, in the acupuncturists group, ReHo of VMPFC/OFC could predict behavioral outcomes, evidenced by negative correlation between unpleasantness ratings and ReHo of VMPFC/OFC and ReHo of SI and MI positively correlated with the duration of acupuncture practice. We suggest that expertise could modulate patterns of local resting state activity by increasing regional clustering strength, which is likely to contribute to advanced local information processing efficiency. Our study completes the understanding of neuroplasticity changes by adding the evidence of local resting state activity alterations, which is helpful for elucidating in what manner training effect extends beyond resting state.
authors: School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China.
authors: Minghao
authors: M
authors: Dong
authors: Wei
authors: W
authors: Qin
authors: Ling
authors: L
authors: Zhao
authors: Xuejuan
authors: X
authors: Yang
authors: Kai
authors: K
authors: Yuan
authors: Fang
authors: F
authors: Zeng
authors: Jinbo
authors: J
authors: Sun
authors: Dahua
authors: D
authors: Yu
authors: Karen M
authors: KM
authors: von Deneen
authors: Fanrong
authors: F
authors: Liang
authors: Jie
authors: J
authors: Tian
mesh_terms: D026881:Acupuncture; D000328:Adult; D002540:Cerebral Cortex; D063132:Connectome / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009044:Motor Cortex / Q000502:physiology; D009048:Motor Skills / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology; D011361:Professional Competence; D012146:Rest / Q000502:physiology; D000078329:Workforce
keywords: acupuncturist; expertise-related functional plasticity; local modulation; regional homogeneity; resting state functional MRI
references: Dermatology. 2006;212(4):343-53
references: 16707884
references: Neuroimage. 2012 Mar;60(1):539-44
references: 22178814
references: Neuroimage. 2009 Mar 1;45(1):75-82
references: 19100845
references: PLoS Comput Biol. 2007 Feb 2;3(2):e17
references: 17274684
references: Nat Rev Neurosci. 2011 Oct 27;12(12):739-51
references: 22033537
references: Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17558-63
references: 19805061
references: Curr Opin Neurobiol. 2005 Apr;15(2):161-7
references: 15831397
references: Neuroscientist. 2010 Oct;16(5):566-77
references: 20889966
references: Neuroimage. 2011 Sep 1;58(1):226-33
references: 21689765
references: Nat Rev Neurosci. 2006 Oct;7(10):811-7
references: 16988656
references: Trends Neurosci. 2010 Jun;33(6):277-84
references: 20226543
references: Brain Cogn. 2009 Mar;69(2):306-15
references: 18783864
references: Neuroimage. 2004 May;22(1):394-400
references: 15110032
references: Neuroimage. 2011 Jan 1;54(1):32-41
references: 20708692
references: Proc Natl Acad Sci U S A. 2011 May 3;108(18):7641-6
references: 21502525
references: Neuropsychologia. 2005;43(2):199-215
references: 15707905
references: Curr Opin Neurobiol. 2006 Dec;16(6):723-7
references: 17084617
references: Addict Biol. 2013 Jul;18(4):729-31
references: 21812873
references: Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12601-5
references: 16116098
references: Neuroimage. 2007 Oct 1;37(4):1083-90; discussion 1097-9
references: 17719799
references: Neuroimage. 2011 Aug 15;57(4):1492-8
references: 21672633
references: Neuroimage. 2009 Oct 15;48(1):117-25
references: 19520171
references: Neuroreport. 2004 Jun 7;15(8):1279-82
references: 15167549
references: Nat Rev Neurol. 2010 Jan;6(1):15-28
references: 20057496
references: Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17152-6
references: 17940025
references: Neuroimage. 2011 May 1;56(1):290-8
references: 21334442
references: Trends Neurosci. 2002 Jan;25(1):27-31
references: 11801335
references: J Neurosci. 2008 Apr 16;28(16):4210-5
references: 18417700
references: Cereb Cortex. 2005 Aug;15(8):1089-102
references: 15616134
references: NMR Biomed. 2012 May;25(5):806-12
references: 22020869
references: Neuroscientist. 2011 Apr;17(2):185-96
references: 21403182
references: Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82
references: 11209064
references: Psychol Bull. 2000 Nov;126(6):890-909
references: 11107881
references: J Neurosci. 2004 Jan 14;24(2):442-6
references: 14724242
references: Hum Brain Mapp. 2011 Aug;32(8):1290-9
references: 20665717
references: Magn Reson Med. 1995 Oct;34(4):537-41
references: 8524021
references: Soc Cogn Affect Neurosci. 2013 Jan;8(1):4-14
references: 22446298
references: Neuroimage. 2011 Sep 1;58(1):10-5
references: 21704173
references: Brain. 1994 Feb;117 ( Pt 1):149-67
references: 8149208
references: Nature. 2010 Jun 10;465(7299):788-92
references: 20473285
references: Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11483-8
references: 17596341
references: Curr Biol. 2006 Dec 5;16(23):R998-1000
references: 17141608
references: Curr Biol. 2009 May 26;19(10):837-42
references: 19398335
references: Front Syst Neurosci. 2010 May 14;4:13
references: 20577591
references: Neuroimage. 2009 Apr 15;45(3):672-8
references: 19280691
references: Cereb Cortex. 2007 Jan;17(1):192-204
references: 16467562
references: Curr Opin Neurobiol. 1999 Apr;9(2):203-8
references: 10322189
references: Somatosens Mot Res. 1999;16(3):197-206
references: 10527368
references: Neuroimage. 2012 Jan 2;59(1):745-9
references: 21763432
references: J Neurosci. 2003 Apr 15;23(8):3439-45
references: 12716952
references: Neuropsychologia. 1971 Mar;9(1):97-113
references: 5146491
references: Curr Biol. 2007 Oct 9;17(19):1708-13
references: 17900903
references: Neuroimage. 2011 Feb 1;54(3):2492-502
references: 20946964
references: Cereb Cortex. 2009 Nov;19(11):2746-54
references: 19321653
references: Curr Biol. 2009 Jun 23;19(12):1023-7
references: 19427210
references: Hum Brain Mapp. 1997;5(3):206-15
references: 20408216
references: Neuropsychologia. 2003;41(3):252-62
references: 12457751
references: Hum Brain Mapp. 2005 Aug;25(4):370-7
references: 15852384
references: Cereb Cortex. 2010 May;20(5):1144-52
references: 19692631
references: Behav Brain Res. 2008 Sep 1;192(1):137-42
references: 18378330