title: Drug-induced lupus and autoimmune hepatitis secondary to infliximab for psoriasis.
abstract: We describe a case of previously unreported autoimmune hepatitis and lupus-like syndrome induced by infliximab treatment for chronic plaque psoriasis. The condition resolved after withdrawal of infliximab, with the liver injury having been reversed and minimal periportal fibrosis. In a two-part discussion we review the current literature on the pharmacology of infliximab and provide recommendations for management of infliximab side effects.
authors: Dermatology Department, Monash University, Australia; Eastern Health Clinical School, Monash University, Australia.
authors: Lucy J
authors: LJ
authors: Dang
authors: John S
authors: JS
authors: Lubel
authors: Shyamalar
authors: S
authors: Gunatheesan
authors: Patrick
authors: P
authors: Hosking
authors: John
authors: J
authors: Su
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000494:pharmacology; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D019693:Hepatitis, Autoimmune / Q000209:etiology*; D006801:Humans; D000069285:Infliximab; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced*; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D000069285:Infliximab
keywords: adverse drug reaction; dermatology; gastroenterology; hepatitis; psoriasis