title: Quantification of the variability in response to propofol administration in children.
abstract: Closed-loop control of anesthesia is expected to decrease drug dosage and wake up time while increasing patient safety and decreasing the work load of the anesthesiologist. The potential of closed-loop control in anesthesia has been demonstrated in several clinical studies. One of the challenges in the development of a closed-loop system that can be widely accepted by clinicians and regulatory authorities is the effect of interpatient variability in drug sensitivity. This system uncertainty may lead to unacceptable performance, or even instability of the closed-loop system for some individuals. The development of reliable models of the effect of anesthetic drugs and characterization of the uncertainty is, therefore, an important step in the development of a closed-loop system. Model identification from clinical data is challenging due to limited excitation and the lack of validation data. In this paper, approximate models are validated for controller design by evaluating the predictive accuracy of the closed-loop behavior. A set of 47 validated models that describe the interpatient variability in the response to propofol in children is presented. This model set can be used for robust linear controller design provided that the experimental conditions are similar to the conditions during data collection.
authors: Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. klaskeh@ece.ubc.ca
authors: Klaske
authors: K
authors: van Heusden
authors: J Mark
authors: JM
authors: Ansermino
authors: Kristian
authors: K
authors: Soltesz
authors: Sara
authors: S
authors: Khosravi
authors: Nicholas
authors: N
authors: West
authors: Guy A
authors: GA
authors: Dumont
mesh_terms: D000293:Adolescent; D000758:Anesthesia / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002648:Child; D005246:Feedback; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D017711:Nonlinear Dynamics; D015742:Propofol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D013813:Therapy, Computer-Assisted
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol