title: New trends in cytochrome p450 research at the half-century mark.
abstract: Cytochrome P450 enzymes have major roles in the metabolism of steroids, drugs, carcinogens, eicosanoids, and numerous other chemicals. The P450s are collectively considered the most diverse catalysts known in biochemistry, although they operate from a basic structural fold and catalytic mechanism. The four minireviews in this thematic series deal with the unusual aspects of catalytic reactions and electron transfer pathway organization, the structural diversity of P450s, and the expanding roles of P450s in disease and medicine.
authors: Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA. f.guengerich@vanderbilt.edu
authors: F Peter
authors: FP
authors: Guengerich
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008658:Inactivation, Metabolic; D008967:Molecular Biology / Q000639:trends; D010084:Oxidation-Reduction; D013256:Steroids / Q000096:biosynthesis
chemical_list: D013256:Steroids; D003577:Cytochrome P-450 Enzyme System
keywords: Carcinogenesis; Cytochrome P450; Cytochromes; Drug Metabolism; Oxidase; Oxidation-Reduction; Steroidogenesis
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