title: Bimanual motor coordination in older adults is associated with increased functional brain connectivity--a graph-theoretical analysis.
abstract: In bimanual coordination, older and younger adults activate a common cerebral network but the elderly also have additional activation in a secondary network of brain areas to master task performance. It remains unclear whether the functional connectivity within these primary and secondary motor networks differs between the old and the young and whether task difficulty modulates connectivity. We applied graph-theoretical network analysis (GTNA) to task-driven fMRI data in 16 elderly and 16 young participants using a bimanual coordination task including in-phase and anti-phase flexion/extension wrist movements. Network nodes for the GTNA comprised task-relevant brain areas as defined by fMRI activation foci. The elderly matched the motor performance of the young but showed an increased functional connectivity in both networks across a wide range of connectivity metrics, i.e., higher mean connectivity degree, connection strength, network density and efficiency, together with shorter mean communication path length between the network nodes and also a lower betweenness centrality. More difficult movements showed an increased connectivity in both groups. The network connectivity of both groups had "small world" character. The present findings indicate (a) that bimanual coordination in the aging brain is associated with a higher functional connectivity even between areas also activated in young adults, independently from task difficulty, and (b) that adequate motor coordination in the context of task-driven bimanual control in older adults may not be solely due to additional neural recruitment but also to aging-related changes of functional relationships between brain regions.
authors: Motor Control Laboratory, Research Center for Movement Control and Neuroplasticity, Group Biomedical Sciences, KU Leuven, Leuven-Heverlee, Belgium. marcus.heitger@gmail.com
authors: Marcus H
authors: MH
authors: Heitger
authors: Daniel J
authors: DJ
authors: Goble
authors: Thijs
authors: T
authors: Dhollander
authors: Patrick
authors: P
authors: Dupont
authors: Karen
authors: K
authors: Caeyenberghs
authors: Alexander
authors: A
authors: Leemans
authors: Stefan
authors: S
authors: Sunaert
authors: Stephan P
authors: SP
authors: Swinnen
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology; D001696:Biomechanical Phenomena; D001921:Brain / Q000166:cytology / Q000502:physiology*; D054022:Cerebrum / Q000166:cytology / Q000502:physiology; D003196:Computer Graphics; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009043:Motor Activity / Q000502:physiology*; D009415:Nerve Net / Q000166:cytology / Q000502:physiology*
references: Brain. 2003 Apr;126(Pt 4):873-88
references: 12615645
references: PLoS One. 2010 Oct 28;5(10):e13701
references: 21060892
references: Neurobiol Aging. 2008 Sep;29(9):1434-46
references: 17566608
references: Neurobiol Dis. 1997;4(3-4):170-85
references: 9361294
references: Front Syst Neurosci. 2010 Jun 07;4:17
references: 20589101
references: Neuropsychol Rev. 2009 Dec;19(4):504-22
references: 19876740
references: Neuroimage. 2010 Aug 15;52(2):643-57
references: 20434565
references: Neurobiol Aging. 2012 Sep;33(9):1900-12
references: 21872363
references: Neurosci Biobehav Rev. 2010 Apr;34(5):721-33
references: 19850077
references: Annu Rev Clin Psychol. 2011;7:113-40
references: 21128784
references: Neurology. 2002 Feb 26;58(4):630-5
references: 11865144
references: J Psychiatr Res. 1975 Nov;12(3):189-98
references: 1202204
references: PLoS One. 2007 Oct 17;2(10):e1049
references: 17940613
references: Nature. 1998 Jun 4;393(6684):440-2
references: 9623998
references: Neuropsychology. 2003 Jul;17(3):339-52
references: 12959500
references: J Neurosci. 2005 Jul 20;25(29):6787-96
references: 16033888
references: Neuroimage. 2002 Nov;17(3):1394-402
references: 12414279
references: Trends Cogn Sci. 2002 Sep 1;6(9):394
references: 12200182
references: Cereb Cortex. 2005 Sep;15(9):1332-42
references: 15635061
references: Magn Reson Med. 2003 May;49(5):953-61
references: 12704779
references: Nat Rev Neurosci. 2009 Mar;10(3):186-98
references: 19190637
references: Neuroimage. 2009 Oct 1;47(4):1854-62
references: 19539766
references: Curr Opin Neurobiol. 2005 Apr;15(2):245-51
references: 15831410
references: Neurosci Biobehav Rev. 2002 Nov;26(7):819-25
references: 12470693
references: Neurosci Lett. 2007 Aug 23;423(3):189-93
references: 17709202
references: J Neurosci. 2011 Mar 23;31(12):4496-503
references: 21430150
references: J Cogn Neurosci. 2011 Sep;23(9):2171-85
references: 20954936
references: Neuroimage. 2011 Jan 15;54(2):875-91
references: 20817103
references: Rev Neurosci. 2010;21(3):187-221
references: 20879692
references: Neuroimage. 2010 Apr 15;50(3):862-72
references: 20093190
references: J Physiol. 2005 Jan 15;562(Pt 2):605-15
references: 15513939
references: Ageing Res Rev. 2006 Aug;5(3):239-54
references: 16905372
references: Neurosci Lett. 2007 Jul 18;422(3):164-8
references: 17611031
references: Neuroimage. 2002 Dec;17(4):1720-8
references: 12498746
references: Neuroimage. 2010 Sep;52(3):1059-69
references: 19819337
references: Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Nov;70(5 Pt 2):056110
references: 15600695
references: Hum Mov Sci. 2010 Oct;29(5):820-30
references: 19931202
references: J Neurosci. 2008 Jan 2;28(1):91-9
references: 18171926
references: Hum Brain Mapp. 2007 Oct;28(10):967-78
references: 17133390
references: Neuropsychologia. 1971 Mar;9(1):97-113
references: 5146491
references: J Neurosci. 2007 Feb 7;27(6):1334-45
references: 17287508
references: Neuroimage. 2008 Jan 15;39(2):566-77
references: 17951075
references: Neuroimage. 2009 Feb 1;44(3):715-23
references: 19027073
references: Magn Reson Med. 2000 Aug;44(2):259-68
references: 10918325
references: PLoS Comput Biol. 2007 Feb 2;3(2):e17
references: 17274684
references: Neuroimage. 2006 Aug 1;32(1):228-37
references: 16777436
references: Neurobiol Aging. 2011 May;32(5):916-32
references: 19570593
references: Hum Brain Mapp. 2010 Aug;31(8):1281-95
references: 20082331
references: Neuropsychologia. 2010 Mar;48(4):1165-70
references: 19941878
references: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4637-42
references: 15070770
references: Cereb Cortex. 2007 Jan;17(1):92-9
references: 16452642
references: PLoS Comput Biol. 2008 Jun 27;4(6):e1000100
references: 18584043
references: Brain. 2008 Apr;131(Pt 4):945-61
references: 18299296
references: Neurobiol Aging. 2012 Apr;33(4):833.e27-37
references: 22015314
references: Stroke. 2001 Jan;32(1):139-46
references: 11136929
references: Psychol Sci. 2009 Jan;20(1):74-84
references: 19152542
references: Neuroimage. 2010 Jan 1;49(1):32-43
references: 19699804
references: Neuron. 2007 Dec 6;56(5):924-35
references: 18054866