title: Mechanisms underlying modulation of the pharmacological properties of pegylated erythropoietin by pegylated hyaluronate-endo-β-N-acetylhexosaminidase.
abstract: Pegylated hyaluronate-endo-β-N-acetylhexosaminidase was shown to potentiate significantly the hemostimulatory effect of pegylated erythropoietin. It was found that enhanced production of hemopoietin by adherent and non-adherent cells of the hemopoiesis-inducing microenvironment and elevated serum content of endogenous erythropoietin along with increased susceptibility of erythroid precursors to pegylated erythropoietin underlay this phenomenon.
authors: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
authors: A M
authors: AM
authors: Dygai
authors: G N
authors: GN
authors: Zyuz'kov
authors: V V
authors: VV
authors: Zhdanov
authors: E V
authors: EV
authors: Udut
authors: L A
authors: LA
authors: Miroshnichenko
authors: E V
authors: EV
authors: Simanina
authors: R V
authors: RV
authors: Gurto
authors: M Ju
authors: MJ
authors: Minakova
authors: A V
authors: AV
authors: Chaikovsky
authors: T S
authors: TS
authors: Markova
authors: L A
authors: LA
authors: Stavrova
authors: A V
authors: AV
authors: Artamonov
authors: A A
authors: AA
authors: Bekarev
authors: P G
authors: PG
authors: Madonov
authors: D N
authors: DN
authors: Kinsht
mesh_terms: D000740:Anemia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D016190:Carboplatin; D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D041905:Erythroid Cells / Q000187:drug effects; D004921:Erythropoietin / Q000008:administration & dosage / Q000494:pharmacology*; D006397:Hematinics / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D013234:Stem Cells / Q000187:drug effects / Q000502:physiology; D001619:beta-N-Acetylhexosaminidases / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D006397:Hematinics; D011994:Recombinant Proteins; C508174:pegylated erythropoietin; D004921:Erythropoietin; D011092:Polyethylene Glycols; D016190:Carboplatin; D001619:beta-N-Acetylhexosaminidases; C584942:pegylated hyaluronate-endo-beta-N-acetylhexosaminidase