title: Metal contaminated soil from mining area caused metal accumulation and biological responses in rats.
abstract: In order to assess the effects of metal contamination on wildlife, we collected wild black rats (Rattus sp.) from mining areas (Kabwe and Chingola) and a control area (Lusaka) in Zambia and compared metal and metallothionein (MT) levels in their tissues. Furthermore, we exposed metal-contaminated soil from Kabwe to laboratory Wistar rats (Rattus norvegicus) for one year in order to determine the accumulation factors and effects of metals caused by soil exposure. Results of both the field and laboratory studies suggested that metal-contaminated soil caused accumulation and biological responses such as elevation of MT-2 mRNA expression levels in rats.
authors: Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo 060-0818, Japan.
authors: Shouta M M
authors: SM
authors: Nakayama
authors: Yoshinori
authors: Y
authors: Ikenaka
authors: Kaampwe
authors: K
authors: Muzandu
authors: Kennedy
authors: K
authors: Choongo
authors: John
authors: J
authors: Yabe
authors: Takashi
authors: T
authors: Umemura
authors: Mayumi
authors: M
authors: Ishizuka
mesh_terms: D000818:Animals; D000835:Animals, Wild; D001842:Bone and Bones / Q000737:chemistry; D001921:Brain / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D007668:Kidney / Q000737:chemistry / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008168:Lung / Q000737:chemistry / Q000378:metabolism; D053517:Matrix Metalloproteinase 15 / Q000235:genetics / Q000378:metabolism; D008670:Metals / Q000737:chemistry*; D051381:Rats; D012989:Soil Pollutants / Q000378:metabolism* / Q000633:toxicity*; D013977:Tibia
chemical_list: D008670:Metals; D012989:Soil Pollutants; D053517:Matrix Metalloproteinase 15