title: Transfusion-related acute lung injury in the Canadian paediatric population.
abstract: BACKGROUND
  The incidence of transfusion-related acute lung injury (TRALI) in adults is approximately one per 5000 transfusions. The Canadian Paediatric Surveillance Program undertook the present study to determine the incidence of TRALI in the paediatric population and to describe the characteristics and outcomes of children with TRALI.
  
  
  METHODS
  The present surveillance study was conducted over a three-year period.
  
  
  RESULTS
  Four TRALI cases were reported, yielding an incidence rate of 1.8 per 100,000 transfusions. The degree of severity varied: in two patients, only supplemental oxygen was necessary, while the other two required mechanical ventilation.
  
  
  CONCLUSIONS
  TRALI was reported much less often in the present study compared with adult studies; therefore, it needs to be determined whether TRALI occurs less frequently in children, or alternatively, whether TRALI is recognized less often in children. The possibility that neonates who undergo cardiac surgery are at greater risk of TRALI than other patients should be addressed in future studies.
authors: Department of Paediatrics, CHU Sainte-Justine, Université de Montréal;
authors: France
authors: F
authors: Gauvin
authors: Pierre
authors: P
authors: Robillard
authors: Heather
authors: H
authors: Hume
authors: Danielle
authors: D
authors: Grenier
authors: Robin K
authors: RK
authors: Whyte
authors: Kathryn E
authors: KE
authors: Webert
authors: Dean
authors: D
authors: Fergusson
authors: Wendy
authors: W
authors: Lau
authors: Norbert
authors: N
authors: Froese
authors: Gilles
authors: G
authors: Delage
keywords: Acute lung injury; Blood transfusion; Child; Paediatrics; TRALI
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