title: Thrombelastographic evaluation of the influence of 2-RBC apheresis on donor's coagulation system.
abstract: Rotation thrombelastogram (ROTEM®/TEG®) assays allow rapid global assessment of hemostatic function using whole blood. Since published data about the effects of automated red cell collection on coagulation system are scarce, we aimed to investigate the effects of 2-RBC apheresis on donor's coagulation system using ROTEM® assays. In INTEM assay, CFT was significantly shortened 24h after apheresis compared with baseline value (p<0.05) and MCF was significantly prolonged immediately after apheresis and 24h after apheresis compared with baseline value (p<0.05 and p<0.01, respectively). In EXTEM assay, CFT was significantly prolonged immediately after apheresis and 24h after apheresis compared with baseline value (p=0.001 and p<0.001, respectively) and MCF was significantly prolonged 24h after apheresis compared with baseline value (p<0,001). Our results demonstrate thromboelastographic signs of hypercoagulability in donors undergoing 2-RBC apheresis.
authors: Department of Hematology, Eskişehir Osmangazi University Medical School, Eskisehir 26480, Turkey. olga.akay@hotmail.com
authors: Olga Meltem
authors: OM
authors: Akay
authors: Mustafa
authors: M
authors: Karagulle
authors: Gokhan
authors: G
authors: Kus
authors: Fezan Sahın
authors: FS
authors: Mutlu
authors: Eren
authors: E
authors: Gunduz
mesh_terms: D000328:Adult; D001331:Automation; D001777:Blood Coagulation; D001781:Blood Component Removal / Q000379:methods*; D001782:Blood Donors; D004912:Erythrocytes / Q000166:cytology*; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012306:Risk; D013916:Thrombelastography / Q000379:methods*; D019851:Thrombophilia / Q000097:blood; D013927:Thrombosis; D013997:Time Factors; D055815:Young Adult