title: cAMP and mitochondria.
abstract: Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial proteins have just started to be investigated, and the presence of cAMP-generating enzymes and PKA inside mitochondria is still controversial. Here, we discuss the role of cAMP in regulating mitochondrial bioenergetics through protein phosphorylation and the evidence for soluble adenylyl cyclase as the source of cAMP inside mitochondria.
authors: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, USA.
authors: Federica
authors: F
authors: Valsecchi
authors: Lavoisier S
authors: LS
authors: Ramos-Espiritu
authors: Jochen
authors: J
authors: Buck
authors: Lonny R
authors: LR
authors: Levin
authors: Giovanni
authors: G
authors: Manfredi
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism; D010766:Phosphorylation; D015290:Second Messenger Systems
chemical_list: D024101:Mitochondrial Proteins; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D000262:Adenylyl Cyclases
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