title: Pd-catalyzed one-pot synthesis of polysubstituted acrylamidines from isocyanides, diazo compounds, and imines.
abstract: A novel and efficient Pd-catalyzed one-pot reaction of ethyl diazoacetate, isocyanides, and imines for the synthesis of acrylamidines was developed. The multicomponent reaction may have occurred through an unpredicted ring-opening process of the ketenimine-imine [2 + 2] intermediate to form the acrylamidine products.
authors: College of Chemistry and Chemical Engineering, Hunan Normal University , No. 36 Lushan Road, Changsha, Hunan, 410081, China, and Key State Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , No. 190 Kaiyuan Avenue, Guangzhou Science Park, Guangzhou, 510530, China.
authors: Xu
authors: X
authors: Yan
authors: Jinxi
authors: J
authors: Liao
authors: Yongzhi
authors: Y
authors: Lu
authors: Jinsong
authors: J
authors: Liu
authors: Youlin
authors: Y
authors: Zeng
authors: Qian
authors: Q
authors: Cai
mesh_terms: D000178:Acrylamides / Q000138:chemical synthesis* / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000178:Acrylamides; D001391:Azo Compounds; D003486:Cyanides; D007097:Imines; D010165:Palladium