title: Determination of voriconazole serum concentration by bioassay, a valid method for therapeutic drug monitoring for clinical laboratories.
abstract: We describe here a simple, fast, and reliable bioassay method for therapeutic drug monitoring of voriconazole. Fifty-eight clinical and external quality control samples were evaluated with this microbiological assay, and results were compared with those obtained with a previously validated chromatographic method. A good correlation between both assays was observed. This particular microbiological method was demonstrated to be simple and offers enough precision and accuracy to perform voriconazole therapeutic drug monitoring in laboratories without specialized equipment.
authors: Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors: Emilio
authors: E
authors: Cendejas-Bueno
authors: Manuel
authors: M
authors: Cuenca-Estrella
authors: Alicia
authors: A
authors: Gomez-Lopez
mesh_terms: D000935:Antifungal Agents / Q000097:blood*; D002175:Candida / Q000187:drug effects*; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000097:blood*; D014230:Triazoles / Q000097:blood*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole
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