title: Ventral hippocampal neurons are shaped by experience to represent behaviorally relevant contexts.
abstract: Memories can be recalled at different levels of resolution, from a detailed rendition of specific events within a single experience to a broad generalization across multiple related experiences. Here we provide evidence that neural representations reflecting the specificity or generality of memories are differentially represented along the dorsoventral axis of the CA3 area of the rat hippocampus. In dorsal CA3, neurons rapidly associate the identity of events with specific locations whereas, in more ventrally located CA3 regions, neurons gradually accumulate information across extended training to form representations that generalize across related events within a spatial context and distinguish events across contexts.
authors: Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA.
authors: Robert W
authors: RW
authors: Komorowski
authors: Carolyn G
authors: CG
authors: Garcia
authors: Alix
authors: A
authors: Wilson
authors: Shoai
authors: S
authors: Hattori
authors: Marc W
authors: MW
authors: Howard
authors: Howard
authors: H
authors: Eichenbaum
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001245:Association Learning / Q000502:physiology*; D001931:Brain Mapping; D056654:CA3 Region, Hippocampal / Q000166:cytology* / Q000293:injuries / Q000502:physiology*; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity; D005106:Exploratory Behavior / Q000502:physiology; D005793:Generalization, Psychological / Q000502:physiology; D008297:Male; D016202:N-Methylaspartate / Q000633:toxicity; D009474:Neurons / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D012201:Reward
chemical_list: D018690:Excitatory Amino Acid Agonists; D016202:N-Methylaspartate
references: Neurobiol Learn Mem. 2010 Jan;93(1):111-6
references: 19733676
references: Behav Biol. 1974 Dec;12(4):421-44
references: 4217626
references: Behav Neurosci. 2004 Feb;118(1):97-110
references: 14979786
references: J Comp Neurol. 1978 Oct 15;181(4):681-715
references: 690280
references: Neuron. 1999 Jan;22(1):15-7
references: 10027284
references: J Exp Psychol Learn Mem Cogn. 2008 Jul;34(4):769-79
references: 18605867
references: Neurobiol Learn Mem. 2006 Jul;86(1):72-81
references: 16504548
references: J Neurosci. 2010 Feb 3;30(5):1777-87
references: 20130187
references: Science. 2008 Jul 4;321(5885):46-7
references: 18599761
references: J Cogn Neurosci. 2013 Jan;25(1):22-8
references: 23198887
references: Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20942-7
references: 19934062
references: J Neurosci. 1993 Sep;13(9):3916-25
references: 8366351
references: Neuron. 2010 Jan 14;65(1):7-19
references: 20152109
references: Cereb Cortex. 2013 Jan;23(1):80-96
references: 22275474
references: Learn Mem. 2007 Nov 14;14(11):705-13
references: 18007015
references: Neuroreport. 1994 Oct 27;5(16):2045-8
references: 7865741
references: Neural Comput. 1996 Aug 15;8(6):1185-202
references: 8768391
references: J Neurosci. 2011 May 25;31(21):7715-28
references: 21613484
references: Neurobiol Learn Mem. 2011 Sep;96(2):361-6
references: 21742047
references: Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10825-30
references: 12149439
references: Eur J Neurosci. 2004 Feb;19(3):705-12
references: 14984421
references: J Neurosci. 2005 Nov 2;25(44):10074-86
references: 16267214
references: Behav Neurosci. 2008 Jun;122(3):643-50
references: 18513134
references: Hippocampus. 2003;13(5):587-603
references: 12921349
references: J Neurosci. 2013 Jan 16;33(3):1002-13
references: 23325238
references: Philos Trans R Soc Lond B Biol Sci. 1996 Oct 29;351(1346):1515-27
references: 8941963
references: PLoS One. 2012;7(11):e48757
references: 23144957
references: J Neurosci. 2003 Aug 27;23(21):7940-9
references: 12944525
references: Neuron. 2007 May 24;54(4):559-66
references: 17521569
references: J Neurosci. 2009 Aug 5;29(31):9918-29
references: 19657042
references: Science. 2008 Jul 4;321(5885):140-3
references: 18599792
references: Science. 2007 Apr 6;316(5821):76-82
references: 17412951
references: Brain Res. 1981 Jul 27;217(1):150-4
references: 7260612
references: J Comp Neurol. 1998 Aug 17;398(1):25-48
references: 9703026
references: Physiol Behav. 2009 Aug 4;98(1-2):103-7
references: 19394353
references: J Neurosci. 1994 Dec;14(12):7347-56
references: 7996180
references: Neurosci Biobehav Rev. 2004 May;28(3):273-83
references: 15225971
references: Hippocampus. 1998;8(6):608-19
references: 9882018
references: Neuron. 2009 Jan 29;61(2):187-202
references: 19186162
references: Hippocampus. 1997;7(6):624-42
references: 9443059
references: Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9697-701
references: 7568200
references: Science. 1997 Mar 21;275(5307):1805-8
references: 9065407
references: Neurobiol Learn Mem. 2008 Jan;89(1):61-9
references: 17931914