title: Optic nerve tortuosity in children with neurofibromatosis type 1.
abstract: BACKGROUND
  Optic nerve tortuosity is often reported in children with neurofibromatosis type 1 (NF1).
  
  
  OBJECTIVE
  To employ quantitative and subjective criteria to assess optic nerve tortuosity in individuals with NF1.
  
  
  METHODS
  A retrospective study over a period of 8 years was performed on children with NF1, with and without optic pathway glioma, compared with children without NF1. A tortuosity index was computed for the optic nerve in each child using a high-resolution 3-D T1-weighted magnetization-prepared rapid gradient-echo sequence, which was averaged and compared across groups.
  
  
  RESULTS
  The tortuosity index for subjects with NF1, regardless of an optic pathway glioma, was greater than those without NF1. There was no difference in the tortuosity index between NF1 subjects with optic pathway glioma and NF1 subjects without optic pathway glioma. There was also no correlation between subjective measures of tortuosity and the quantitative scoring (tortuosity index) or between the degree of tortuosity and subject age or gender.
  
  
  CONCLUSIONS
  Individuals with NF1 have increased optic nerve tortuosity relative to unaffected individuals. Quantitative tortuosity index is a superior measure to subjective assessment in the evaluation of optic nerve tortuosity in children with NF1.
authors: Department of Neurology, Washington University School of Medicine, Box 8111, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
authors: Joyce
authors: J
authors: Ji
authors: Joshua
authors: J
authors: Shimony
authors: Feng
authors: F
authors: Gao
authors: Robert C
authors: RC
authors: McKinstry
authors: David H
authors: DH
authors: Gutmann
mesh_terms: D002648:Child; D005260:Female; D005910:Glioma / Q000150:complications / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology*; D019574:Optic Nerve Neoplasms / Q000150:complications / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014102:Torsion Abnormality / Q000209:etiology / Q000473:pathology*
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