title: [Entry mechanism of morbillivirus family].
abstract: The genus Morbillivirus includes measles virus, canine distemper virus and rinderpest virus. These are highly contagious and exhibit high mortality. These viruses have the attachment glycoprotein, hemagglutinin (H), at the virus surface, which bind to signaling lymphocyte activation molecule (SLAM) and Nectin 4 as receptors for the entry. However, the molecular mechanism for this entry has been limitedly understood. Here we summarize the current topics, (1) newly identified receptor, Nectin 4, (2) crystal structures of H-receptor complexes and (3) detail biochemical studies of the H-F communication for the entry. These provide insight on the mechanism of morbillivirus entry event and furthermore drug developments.
authors: Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University.
authors: Hideo
authors: H
authors: Fukuhara
authors: Surui
authors: S
authors: Chen
authors: Shin
authors: S
authors: Takeda
authors: Katsumi
authors: K
authors: Maenaka
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D003460:Crystallization; D015195:Drug Design; D006389:Hemagglutinins, Viral / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008561:Membrane Fusion; D018103:Morbillivirus / Q000235:genetics* / Q000472:pathogenicity*; D018185:Morbillivirus Infections / Q000235:genetics / Q000821:virology*; D011485:Protein Binding; D020836:Protein Structure, Quaternary; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000378:metabolism; D014765:Viral Vaccines; D000075983:Nectins
chemical_list: D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D006389:Hemagglutinins, Viral; D011956:Receptors, Cell Surface; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D014759:Viral Envelope Proteins; D014765:Viral Vaccines; C442228:NECTIN4 protein, human; D000075983:Nectins