title: Mechanically tunable, self-adjuvanting nanoengineered polypeptide particles.
abstract: DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elasticity and cargo-loading capacity of the obtained particles can be tuned by the amount of cross-linker used to stabilize the polypeptide particles. The use of polypeptide particles as biocarriers provides a promising method for vaccine delivery.
authors: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors: Jiwei
authors: J
authors: Cui
authors: Robert
authors: R
authors: De Rose
authors: James P
authors: JP
authors: Best
authors: Angus P R
authors: AP
authors: Johnston
authors: Sheilajen
authors: S
authors: Alcantara
authors: Kang
authors: K
authors: Liang
authors: Georgina K
authors: GK
authors: Such
authors: Stephen J
authors: SJ
authors: Kent
authors: Frank
authors: F
authors: Caruso
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D001483:Base Sequence; D018899:CpG Islands; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology; D004337:Drug Carriers / Q000378:metabolism; D006801:Humans; D055595:Mechanical Phenomena; D036103:Nanotechnology; D009841:Oligonucleotides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*; D011099:Polyglutamic Acid / Q000737:chemistry; D015202:Protein Engineering
chemical_list: D000276:Adjuvants, Immunologic; D004337:Drug Carriers; D009841:Oligonucleotides; D010455:Peptides; D011099:Polyglutamic Acid
keywords: CpG; adjuvants; mesoporous silica; nanotechnology; polypeptide particles; vaccine delivery