title: [Morphological changes of the colon in patients with irritable bowel syndrome].
abstract: BACKGROUND
  Irritable bowel syndrome (IBS) is a common disease belonging to the group of chronic functional gastrointestinal disorders. Variety of symptoms and lack of macroscopic and structural pathologies in colon, make IBS a challenge both in diagnosis and in medication. According to the last reports, the role of chronic minimal inflammation in colon mucosa is becoming more relevant.
  
  
  OBJECTIVE
  The aim of this study was to verify the microscopic and macroscopic changes in colon mucosa in patients with IBS.
  
  
  METHODS
  A retrospective study of microscopic changes and macroscopic lesions in colon, due to endoscopy biopsies in the group of 89 patients diagnosed with IBS in an average age of 47 years.
  
  
  RESULTS
  Mild inflammation of colonic mucosa in lamina propria was observed in 92% patients, 34% presented other inflammatory cells. No statistical relationship between macroscopic lesions (in 44% cases) and lymphatic infiltration was observed.
  
  
  CONCLUSIONS
  Low grade inflammation of lamina propria in colon was observed among patients with IBS. Beside the edema of the lamina propria, no correlation between macroscopic and microscopic changes was found. Despite the fact that IBS is a functional disorder, in many patients occur morphological changes in colon mucosa. Further studies are necessary.
authors: Oddzial Kliniczny Kliniki Gastroenterologii i Hepatologii oraz Chorób Zakaźnych Szpitala Uniwersyteckiego, Kraków, Polska. igawierzbicka@gmail.com
authors: Iga
authors: I
authors: Wierzbicka-Tutka
authors: Irena
authors: I
authors: Ciećko-Michalska
authors: Konrad
authors: K
authors: Jabłoński
authors: Dariusz
authors: D
authors: Adamek
authors: Tomasz
authors: T
authors: Mach
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D003092:Colitis / Q000150:complications / Q000473:pathology; D003106:Colon / Q000473:pathology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult