title: Infrared laser thermal fusion of blood vessels: preliminary ex vivo tissue studies.
abstract: Suture ligation of blood vessels during surgery can be time-consuming and skill-intensive. Energy-based, electrosurgical, and ultrasonic devices have recently replaced the use of sutures and mechanical clips (which leave foreign objects in the body) for many surgical procedures, providing rapid hemostasis during surgery. However, these devices have the potential to create an undesirably large collateral zone of thermal damage and tissue necrosis. We explore an alternative energy-based technology, infrared lasers, for rapid and precise thermal coagulation and fusion of the blood vessel walls. Seven near-infrared lasers (808, 980, 1075, 1470, 1550, 1850 to 1880, and 1908 nm) were tested during preliminary tissue studies. Studies were performed using fresh porcine renal vessels, ex vivo, with native diameters of 1 to 6 mm, and vessel walls flattened to a total thickness of 0.4 mm. A linear beam profile was applied normal to the vessel for narrow, full-width thermal coagulation. The laser irradiation time was 5 s. Vessel burst pressure measurements were used to determine seal strength. The 1470 nm laser wavelength demonstrated the capability of sealing a wide range of blood vessels from 1 to 6 mm diameter with burst strengths of 578 ± 154, 530 ± 171, and 426 ± 174  mmHg for small, medium, and large vessel diameters, respectively. Lateral thermal coagulation zones (including the seal) measured 1.0 ± 0.4  mm on vessels sealed at this wavelength. Other laser wavelengths (1550, 1850 to 1880, and 1908 nm) were also capable of sealing vessels, but were limited by lower vessel seal pressures, excessive charring, and/or limited power output preventing treatment of large vessels (>4  mm outer diameter).
authors: University of North Carolina at Charlotte, Department of Physics and Optical Science, Charlotte, NC 28223, USA.
authors: Christopher M
authors: CM
authors: Cilip
authors: Sarah B
authors: SB
authors: Rosenbury
authors: Nicholas
authors: N
authors: Giglio
authors: Thomas C
authors: TC
authors: Hutchens
authors: Gino R
authors: GR
authors: Schweinsberger
authors: Duane
authors: D
authors: Kerr
authors: Cassandra
authors: C
authors: Latimer
authors: William H
authors: WH
authors: Nau
authors: Nathaniel M
authors: NM
authors: Fried
mesh_terms: D000818:Animals; D007259:Infrared Rays; D007668:Kidney / Q000098:blood supply; D017075:Laser Coagulation / Q000295:instrumentation* / Q000379:methods; D007834:Lasers; D008955:Models, Cardiovascular; D012082:Renal Veins / Q000033:anatomy & histology* / Q000473:pathology / Q000528:radiation effects / Q000601:surgery; D013552:Swine