title: Application of the National Institute on Aging-Alzheimer's Association AD criteria to ADNI.
abstract: OBJECTIVE
  We describe the operationalization of the National Institute on Aging-Alzheimer's Association (NIA-AA) workgroup diagnostic guidelines pertaining to Alzheimer disease (AD) dementia in a large multicenter group of subjects with AD dementia.
  
  
  METHODS
  Subjects with AD dementia from the Alzheimer's Disease Neuroimaging Initiative (ADNI) with at least 1 amyloid biomarker (n = 211) were included in this report. Biomarker data from CSF Aβ42, amyloid PET, fluorodeoxyglucose-PET, and MRI were examined. The biomarker results were assessed on a per-patient basis and the subject categorization as defined in the NIA-AA workgroup guidelines was determined.
  
  
  RESULTS
  When using a requirement that subjects have a positive amyloid biomarker and single neuronal injury marker having an AD pattern, 87% (48% for both neuronal injury biomarkers) of the subjects could be categorized as "high probability" for AD. Amyloid status of the combined Pittsburgh compound B-PET and CSF results showed an amyloid-negative rate of 10% in the AD group. In the ADNI AD group, 5 of 92 subjects fit the category "dementia unlikely due to AD" when at least one neuronal injury marker was negative.
  
  
  CONCLUSIONS
  A large proportion of subjects with AD dementia in ADNI may be categorized more definitively as high-probability AD using the proposed biomarker scheme in the NIA-AA criteria. A minority of subjects may be excluded from the diagnosis of AD by using biomarkers in clinically categorized AD subjects. In a well-defined AD dementia population, significant biomarker inconsistency can be seen on a per-patient basis.
authors: Department of Radiology, Mayo Clinic, Rochester, MN, USA. vlowe@mayo.edu
authors: Val J
authors: VJ
authors: Lowe
authors: Patrick J
authors: PJ
authors: Peller
authors: Stephen D
authors: SD
authors: Weigand
authors: Catalina
authors: C
authors: Montoya Quintero
authors: Nirubol
authors: N
authors: Tosakulwong
authors: Prashanthi
authors: P
authors: Vemuri
authors: Matthew L
authors: ML
authors: Senjem
authors: Lennon
authors: L
authors: Jordan
authors: Clifford R
authors: CR
authors: Jack
authors: David
authors: D
authors: Knopman
authors: Ronald C
authors: RC
authors: Petersen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000145:classification* / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology; D015415:Biomarkers; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D054561:National Institute on Aging (U.S.) / Q000592:standards*; D049268:Positron-Emission Tomography; D012042:Registries / Q000706:statistics & numerical data*; D012955:Societies, Medical / Q000592:standards; D014481:United States
chemical_list: D015415:Biomarkers; D019788:Fluorodeoxyglucose F18
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