title: Radiotherapy for a repeatedly recurrent ameloblastoma with malignant transformation.
abstract: BACKGROUND
  The role of radiation therapy (RT) for ameloblastoma remains controversial and undetermined due to the rarity of the disease.
  
  
  METHODS
  A case of repeatedly recurrent ameloblastoma with malignant transformation is presented. The clinical course and managements are described.
  
  
  RESULTS
  The 63-year-old man had a recurrent ameloblastoma in the left mandible. Five years after the first surgical resection, he underwent 8 more rounds of surgical excision of the recurrent tumors. The malignant transformation occurred and the unresectable tumor invaded the masticator space, parapharyngeal space, and skull base. He received 3-dimensional conformal RT, at the dose of 66 Gray (Gy) in 33 fractions. The ulcerative exophytic mass had regressed gradually. After follow-up of 28 months, the tumor was well controlled.
  
  
  CONCLUSIONS
  RT seems to be a feasible treatment option for recurrent ameloblastoma with malignant transformation.
authors: Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors: Chun-Ming
authors: CM
authors: Huang
authors: Jin-Yi
authors: JY
authors: Chen
authors: Chung-Ho
authors: CH
authors: Chen
authors: Chih-Jen
authors: CJ
authors: Huang
mesh_terms: D000564:Ameloblastoma / Q000473:pathology* / Q000601:surgery; D001707:Biopsy, Needle; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000532:radiotherapy*; D011862:Radiography, Panoramic / Q000379:methods; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
keywords: ameloblastoma; malignant transformation; radiotherapy