title: Bone mineral density, pulmonary function, chronological age, and age at diagnosis in children and adolescents with cystic fibrosis.
abstract: OBJECTIVE
  To assess bone mineral density in patients with cystic fibrosis (CF), and to correlate it with possible intervening variables.
  
  
  METHODS
  Children and adolescents diagnosed with CF, aged 6 to 18 years, followed at the outpatient clinic were included in the study. First, demographic data were collected and, subsequently, patients underwent a spirometric test. All patients answered the Cystic Fibrosis Quality of Life Questionnaire (CFQ) and underwent the six-minute walk test (6MWT) and bone densitometry (DXA).
  
  
  RESULTS
  A total of 25 CF patients were included, of which 56% were males. The mean age was 12.3±3.4 years; mean height was 149.2±14.4 cm; and mean weight was 44.4±13.9 kg. Most results on pulmonary function and bone mineral density (BMD) were within normal limits. The mean forced expiratory volume in one second (FEV) was 92.5±23.6 (% of predicted), mean forced vital capacity (FVC) was 104.4±21.3 (% of predicted), and1 mean BMD z-score was 0.1±1.0. BMD was moderately correlated with FEV (r = 0.43, p = 0.03) and FVC (r = 0.57, p = 0.003). Regarding chronological age and age at diagnosis, a moderate and inverse correlation was also found (r = -0.55, p = 0.004; r = -0.57, p = 0.003, respectively). However, no significant correlations were found with the data from CFQ, 6MWT, and body mass index.
  
  
  CONCLUSIONS
  Most patients had BMD within normal limits and presented a positive correlation with pulmonary function, as well as a negative correlation with chronological age and age at diagnosis.
authors: Programa de Pós-graduação em Pediatria e Saúde da Criança, Faculdade de Enfermagem, Nutrição e Fisioterapia, Pontifícia Universidade Católica do Rio Grande do Sul PUCRS, Porto Alegre, RS, Brazil. mdonadio@pucrs.br
authors: Márcio V F
authors: MV
authors: Donadio
authors: Guilherme C de
authors: GC
authors: Souza
authors: Gabriele
authors: G
authors: Tiecher
authors: João P
authors: JP
authors: Heinzmann-Filho
authors: Taísa F
authors: TF
authors: Paim
authors: Patrícia X
authors: PX
authors: Hommerding
authors: Paulo J C
authors: PJ
authors: Marostica
mesh_terms: D000293:Adolescent; D000367:Age Factors; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D002648:Child; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D011788:Quality of Life; D013147:Spirometry; D013997:Time Factors; D014797:Vital Capacity / Q000502:physiology*