title: Trait pessimism predicts vulnerability to stress-induced anhedonia in rats.
abstract: Depressive disorder is often associated with cognitive biases. In this study, we took a unique opportunity to investigate whether trait pessimism could predict vulnerability to stress-induced anhedonia in an animal model of depression. In a series of ambiguous-cue interpretation (ACI) tests, we identified animals displaying 'pessimistic' and 'optimistic' traits. Subsequently, the rats were subjected to chronic restraint, and the trait differences in response to stress were investigated using sucrose preference and ACI tests before, during and after the stress regime. Although stress resulted in anhedonia in both subgroups, it occurred faster and lasted longer in the 'pessimistic' compared with the 'optimistic' animals. Chronic stress exposure also increased the negative judgment bias in rats, although this effect was not dependent on the 'pessimistic' trait. For the first time, we demonstrated a link between cognitive judgment bias and vulnerability to stress-induced anhedonia in an animal model. We also introduced a cognitive biomarker, which may be of value for etiological depression studies.
authors: Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland.
authors: Rafal
authors: R
authors: Rygula
authors: Justyna
authors: J
authors: Papciak
authors: Piotr
authors: P
authors: Popik
mesh_terms: D059445:Anhedonia; D000818:Animals; D001522:Behavior, Animal; D002755:Choice Behavior; D003071:Cognition; D003216:Conditioning, Operant; D003463:Cues; D003866:Depressive Disorder / Q000150:complications / Q000523:psychology; D008297:Male; D051381:Rats; D013315:Stress, Psychological / Q000150:complications / Q000523:psychology*; D035501:Uncertainty
references: Neuropsychopharmacology. 2004 Nov;29(11):2007-17
references: 15266352
references: Emotion. 2007 Feb;7(1):201-6
references: 17352575
references: Anim Cogn. 2010 Sep;13(5):721-31
references: 20464439
references: Am J Psychiatry. 1978 May;135(5):525-33
references: 645943
references: J Neurosci. 2010 Nov 10;30(45):15007-18
references: 21068306
references: Eur Neuropsychopharmacol. 1992 Mar;2(1):43-9
references: 1638173
references: Psychoneuroendocrinology. 2011 Jan;36(1):28-39
references: 20580164
references: Nature. 2004 Jan 22;427(6972):312
references: 14737158
references: Physiol Behav. 2011 Mar 28;102(5):503-10
references: 21236279
references: Am J Psychiatry. 2005 Nov;162(11):2171-3
references: 16263859
references: J Abnorm Psychol. 1986 Feb;95(1):52-9
references: 3700847
references: Psychopharmacology (Berl). 1987;93(3):358-64
references: 3124165
references: Am J Psychiatry. 2008 Aug;165(8):969-77
references: 18628348
references: PLoS One. 2012;7(8):e44387
references: 22952968
references: Behav Res Ther. 1999 Jun;37(6):503-31
references: 10372466
references: Biol Psychiatry. 1992 May 1;31(9):947-53
references: 1637932
references: Curr Biol. 2011 Jun 21;21(12):1070-3
references: 21636277
references: Eur J Pharmacol. 1996 Mar 28;299(1-3):1-7
references: 8901000
references: Neurosci Biobehav Rev. 1981 Summer;5(2):231-46
references: 7022272
references: Curr Biol. 2010 Oct 12;20(19):R839-40
references: 20937467
references: Behav Pharmacol. 2003 Sep;14(5-6):465-70
references: 14501259
references: J Pers Soc Psychol. 1984 Jul;47(1):193-203
references: 6747815
references: J Abnorm Psychol. 1999 Aug;108(3):483-9
references: 10466272
references: PLoS One. 2012;7(12):e51959
references: 23300582
references: Neurosci Biobehav Rev. 1992 Winter;16(4):525-34
references: 1480349
references: Psychopharmacology (Berl). 1991;104(2):255-9
references: 1876670
references: Cogn Affect Behav Neurosci. 2010 Mar;10(1):50-70
references: 20233955
references: Pharmacol Biochem Behav. 1989 Aug;33(4):755-9
references: 2616594
references: Psychol Med. 1999 Nov;29(6):1307-21
references: 10616937
references: Neuropsychopharmacology. 2010 Mar;35(4):1008-15
references: 20043002