title: Diffusion tensor imaging of normal-appearing white matter in unilateral cerebral arterial occlusive disease.
abstract: OBJECTIVE
  To use MR with diffusion tensor imaging (DTI) and conventional and high b value to assess diffusion changes in normal-appearing white matter (NAWM) in patients with unilateral, severe stenosis, or occlusion of the middle cerebral artery (MCA).
  
  
  METHODS
  In total, 28 patients with NAWM and unilateral, severe stenosis, or occlusion of the MCA underwent DTI with b values 1000 and 2200 s/mm(2) at 3.0T MR. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), radial diffusivity (eigenvalues λ1 , λ2 ), and axial diffusivity (eigenvalue λ3 ) were measured for the ipsilateral and contralateral corona radiata.
  
  
  RESULTS
  Mean FA was significantly lower for the ipsilateral than contralateral corona radiata with high b value, 2200 s/mm(2) , and ipsilateral corona radiata with conventional low b value, 1000 s/mm(2) (all P < 0.01). Mean ADC, λ1 , λ2 , and λ3 were significantly higher for the ipsilateral than contralateral corona radiata with high b value (all P < 0.05) but not for ipsilateral than contralateral corona radiata with low b value (P > 0.05).
  
  
  CONCLUSIONS
  DTI with a high b value detects diffusion changes in NAWM in patients with unilateral, severe stenosis, or occlusion of the MCA not seen with conventional b value or conventional MRI contrasts.
authors: Department of Radiology, Qi Lu Hospital of Shandong University, Jinan, China.
authors: Xiangshui
authors: X
authors: Meng
authors: Qing
authors: Q
authors: Wang
authors: Jinwen
authors: J
authors: Hou
authors: Xiaoming
authors: X
authors: Zhang
authors: Enguo
authors: E
authors: Wang
authors: Qilu
authors: Q
authors: Li
authors: Qingshi
authors: Q
authors: Zeng
authors: Qian
authors: Q
authors: Wang
authors: Chuanfu
authors: C
authors: Li
authors: Xiangxing
authors: X
authors: Ma
mesh_terms: D000328:Adult; D000368:Aged; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000473:pathology*; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: cerebral arterial occlusion; chronic cerebral ischemia; diffusion tensor imaging; magnetic resonance imaging