title: The effects of angiotensin-converting enzyme-inhibitory peptide LAP on the left common carotid artery remodeling in spontaneously hypertensive rats.
abstract: OBJECTIVE
  To investigate the protective effect of angiotensin-converting enzyme (ACE)-inhibitory peptide LAP on the left common carotid artery remodeling in spontaneously hypertensive rats (SHRs).
  
  
  METHODS
  A cohort of male SHRs were randomly divided into three groups (n = 10 for each group): pseudo-experimental group, enalapril-treated group as a positive control group, ACE-inhibitory peptide LAP-treated group. After the experiment, the left common carotid artery from each rat was removed for morphological evaluation.
  
  
  RESULTS
  It was observed that the vascular medial thickness, media thickness/lumen diameter, medial cross-sectional area and mean nuclear area of smooth muscle cells of the left common carotid artery in the LAP group or enalapril group were significantly lower than those in the pseudo-experimental group, while there was no significant difference in these parameters observed between the LAP group and enalapril group. Additionally, the vascular area percentage of collagen fibers of the left common carotid artery in the LAP group and enalapril group was significantly lower than that of the pseudo-experimental group.
  
  
  CONCLUSIONS
  The protective vessel remodeling effect in SHRs was observed with ACE-inhibitory peptide LAP in SHRs by decreasing blood pressure, inhibiting smooth muscle cell hypertrophy and reducing the proliferation of collagen fibers.
authors: Department of Cardiology, Tongji Hospital Affiliated to Tongji University, Shanghai, 200065, China.
authors: F
authors: F
authors: Hong
authors: H
authors: H
authors: Junling
authors: S
authors: S
authors: Yi
authors: L
authors: L
authors: Chi
authors: Z
authors: Z
authors: Huan
authors: D
authors: D
authors: Yu Qing
authors: L
authors: L
authors: Lingxia
authors: G
authors: G
authors: Yang
authors: L
authors: L
authors: Ming
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D017536:Carotid Artery, Common / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D059168:Carotid Intima-Media Thickness; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D004656:Enalapril / Q000494:pharmacology; D024022:Fibrillar Collagens / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D006984:Hypertrophy; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000473:pathology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D024022:Fibrillar Collagens; D010455:Peptides; D004656:Enalapril
references: Clin Exp Hypertens A. 1989;11 Suppl 2:487-98
references: 2605798
references: J Hypertens. 2008 Feb;26(2):322-33
references: 18192847
references: J Clin Invest. 2000 Jun;105(11):1507-9
references: 10841505
references: Peptides. 2008 Jun;29(6):1062-71
references: 18384915
references: Adv Cardiol. 2007;44:76-95
references: 17075200
references: Peptides. 2010 Jun;31(6):1165-76
references: 20214946
references: Hypertension. 2005 Jun;45(6):1050-5
references: 15851625
references: J Cereb Blood Flow Metab. 2009 Sep;29(9):1547-58
references: 19513084
references: J Dairy Sci. 2010 Jul;93(7):2906-21
references: 20630208
references: Hypertension. 2001 Sep;38(3):439-43
references: 11566919
references: Hypertension. 2001 Apr;37(4):1047-52
references: 11304501
references: Stroke. 2009 Feb;40(2):582-90
references: 19095986
references: Br J Nutr. 2004 Sep;92(3):357-66
references: 15469639
references: Physiol Res. 2006;55 Suppl 1:S81-7
references: 17177629
references: J Renin Angiotensin Aldosterone Syst. 2006 Mar;7(1):31-9
references: 17083071
references: Hypertension. 2005 Mar;45(3):432-7
references: 15655118
references: Handb Exp Pharmacol. 2005;(170):407-42
references: 16596809
references: Hypertension. 2005 Jun;45(6):1194-9
references: 15897362
references: Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1074-9
references: 19407246
references: Biosci Biotechnol Biochem. 2009 Oct;73(10):2203-9
references: 19809178
references: Przegl Lek. 2002;59 Suppl 3:1-8
references: 12652989
references: Hypertension. 2001 Apr;37(4):1101-7
references: 11304510
references: J Exp Med. 1956 Mar 1;103(3):295-9
references: 13295487
references: J Hypertens. 2010 Jul;28(7):1566-73
references: 20589978
references: Int J Cardiol. 2009 May 15;134(2):160-8
references: 19329197
references: Kidney Blood Press Res. 2011;34(5):358-64
references: 21646816
references: Hypertension. 2010 Feb;55(2):494-9
references: 20026758
references: Chin J Physiol. 2006 Apr 30;49(2):67-73
references: 16830788