title: NHC-Cu(I) catalysed asymmetric conjugate silyl transfer to unsaturated lactones: application in kinetic resolution.
abstract: The scope of the asymmetric silyl transfer to unsaturated lactones utilising a C2-symmetric NHC-Cu(I) catalyst has been established and kinetic resolutions mediated by silyl transfer have been used to prepare enantiomerically enriched anti-4,5-disubstituted 5-membered lactones. The method has been exploited in an expedient synthesis of (+)-blastmycinone.
authors: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors: Vittorio
authors: V
authors: Pace
authors: James P
authors: JP
authors: Rae
authors: Hassan Y
authors: HY
authors: Harb
authors: David J
authors: DJ
authors: Procter