title: Increased risk of atrial and ventricular arrhythmia in long-lasting psoriasis patients.
abstract: BACKGROUND
  Several reports have demonstrated an association between psoriasis and cardiovascular diseases. P wave dispersion (PWD) is the most important electrocardiographic (ECG) markers used to evaluate the risk of atrial arrhythmias. QT dispersion (QTD) can be used to assess homogeneity of cardiac repolarization and may be a risk for ventricular arrhythmias.
  
  
  OBJECTIVE
  To search PWD and QTD in patients with psoriasis.
  
  
  METHODS
  Ninety-four outpatient psoriasis patients and 51 healthy people were evaluated by physical examination, 12-lead ECG, and transthoracic echocardiography. Severity of the psoriasis was evaluated by psoriasis area and severity index (PASI).
  
  
  RESULTS
  Mean disease duration was 129.4 ± 83.9 (range, 3-360) months and PASI ranged from 0 to 34.0 (mean ± SD; 7.6 ± 6.7). Compared to control group, psoriatic patients had significantly shorter Pmax and Pmin durations, longer QTcmax, and greater PWD and QTcD. Transmitral deceleration time (DT) and isovolumetric relaxation time (IVRT) were significantly longer among psoriasis patients. QTcD and PWD were significantly correlated with disease duration (r = 0.693, P < 0.001, and r = 0.368, P = 0.003, resp.).
  
  
  CONCLUSIONS
  In this study, we found that both PWD and QTcD are increased in psoriasis patients compared to healthy subjects. In addition, they had longer DT and IVRT.
authors: Cardiology Department, Faculty of Medicine, Yuzunci Yil University, 65200 Van, Turkey. dr.hsimsek@hotmail.com
authors: Hakki
authors: H
authors: Simsek
authors: Musa
authors: M
authors: Sahin
authors: Aytac
authors: A
authors: Akyol
authors: Serkan
authors: S
authors: Akdag
authors: Hatice Uce
authors: HU
authors: Ozkol
authors: Hasan Ali
authors: HA
authors: Gumrukcuoglu
authors: Yilmaz
authors: Y
authors: Gunes
mesh_terms: D000328:Adult; D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000453:epidemiology*; D002908:Chronic Disease; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011565:Psoriasis / Q000175:diagnosis* / Q000453:epidemiology*; D018570:Risk Assessment; D014421:Turkey / Q000453:epidemiology; D014693:Ventricular Fibrillation / Q000175:diagnosis* / Q000453:epidemiology*
references: Ann Rheum Dis. 2005 Mar;64 Suppl 2:ii30-6
references: 15708932
references: Pacing Clin Electrophysiol. 1997 Oct;20(10 Pt 2):2625-40
references: 9358510
references: J Eur Acad Dermatol Venereol. 2004 Mar;18(2):180-3
references: 15009298
references: Am J Cardiol. 2008 Apr 15;101(8):1119-26
references: 18394444
references: J Am Coll Cardiol. 1995 Mar 1;25(3):746-52
references: 7860924
references: JAMA. 1980 Jul 25;244(4):363-5
references: 7392130
references: J Am Coll Cardiol. 1995 Aug;26(2):497-502
references: 7608455
references: J Am Acad Dermatol. 2007 Aug;57(2):347-54
references: 17433490
references: Dermatology. 2005;210(3):194-9
references: 15785046
references: Arch Intern Med. 1987 May;147(5):992
references: 3579451
references: J Intern Med. 1998 Feb;243(2):127-32
references: 9566641
references: Acta Cardiol. 2003 Aug;58(4):303-8
references: 12948035
references: Eur Heart J. 2004 Mar;25(5):363-70
references: 15033247
references: Z Hautkr. 1982 May 15;57(10):734-9
references: 7102023
references: Med Hypotheses. 2005;64(6):1237-8
references: 15823725
references: Am J Clin Dermatol. 2005;6(6):383-92
references: 16343026
references: Int J Cardiol. 2010 Oct 8;144(2):322-4
references: 19285738
references: J Int Med Res. 2007 Nov-Dec;35(6):796-802
references: 18034993
references: Am Heart J. 1998 May;135(5 Pt 1):733-8
references: 9588401
references: Int J Cardiol. 2007 Feb 7;115(2):135-43
references: 16764958
references: Hypertension. 2003 Feb;41(2):237-43
references: 12574088
references: Tex Heart Inst J. 2005;32(2):163-7
references: 16107107
references: J Eur Acad Dermatol Venereol. 2003 Jul;17(4):414-7
references: 12834451
references: Pol Arch Med Wewn. 2002 Jul;108(1):647-51
references: 12412409
references: J Am Acad Dermatol. 1995 Jun;32(6):982-6
references: 7751469
references: Acta Derm Venereol. 2006;86(4):340-4
references: 16874421
references: Pacing Clin Electrophysiol. 2000 Nov;23(11 Pt 2):1859-62
references: 11139943
references: J Am Acad Dermatol. 2006 Nov;55(5):829-35
references: 17052489
references: J Am Coll Cardiol. 2007 Apr 17;49(15):1642-1648
references: 17433956
references: J Investig Med. 2011 Feb;59(2):281-6
references: 21200335
references: J Am Acad Dermatol. 2007 Apr;56(4):629-34
references: 17157411
references: Dermatologica. 1974;148(1):1-18
references: 4831963
references: Card Electrophysiol Rev. 2002 Sep;6(3):215-20
references: 12114841
references: Scand J Rheumatol. 2002;31(1):22-6
references: 11922196
references: Pacing Clin Electrophysiol. 2000 Mar;23(3):352-8
references: 10750136
references: Dermatology. 2008;217(1):27-37
references: 18349542
references: Z Kardiol. 2000;89 Suppl 3:24-35
references: 10810782