title: Subgrouping the autism "spectrum": reflections on DSM-5.
abstract: DSM-5 has moved autism from the level of subgroups ("apples and oranges") to the prototypical level ("fruit"). But making progress in research, and ultimately improving clinical practice, will require identifying subgroups within the autism spectrum.
authors: Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK. mcl45@cam.ac.uk
authors: Meng-Chuan
authors: MC
authors: Lai
authors: Michael V
authors: MV
authors: Lombardo
authors: Bhismadev
authors: B
authors: Chakrabarti
authors: Simon
authors: S
authors: Baron-Cohen
mesh_terms: D002648:Child; D002659:Child Development Disorders, Pervasive / Q000145:classification* / Q000175:diagnosis; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D012720:Severity of Illness Index
references: J Child Psychol Psychiatry. 2004 Feb;45(2):212-29
references: 14982237
references: J Am Acad Child Adolesc Psychiatry. 2012 Apr;51(4):368-83
references: 22449643
references: PLoS Med. 2012;9(3):e1001190
references: 22427747
references: J Am Acad Child Adolesc Psychiatry. 2012 Apr;51(4):347-9
references: 22449639
references: J Child Psychol Psychiatry. 2007 Dec;48(12):1200-7
references: 18093025
references: Neuropsychol Rev. 2011 Dec;21(4):360-89
references: 21989834
references: J Am Acad Child Adolesc Psychiatry. 2011 Jun;50(6):540-2
references: 21621137
references: Dev Med Child Neurol. 2010 Feb;52(2):130-8
references: 20059518
references: J Am Acad Child Adolesc Psychiatry. 2011 Jun;50(6):583-592.e11
references: 21621142
references: Q J Exp Psychol (Hove). 2012;65(11):2073-92
references: 22906000
references: J Autism Dev Disord. 2013 Nov;43(11):2515-25
references: 23504376
references: Neuron. 2011 Jun 9;70(5):898-907
references: 21658583
references: Am J Psychiatry. 2010 Jul;167(7):748-51
references: 20595427
references: Autism Res. 2009 Jun;2(3):157-77
references: 19598235
references: Mol Psychiatry. 2011 Dec;16(12):1213-20
references: 20877284
references: J Autism Dev Disord. 2013 Aug;43(8):1784-97
references: 23224513
references: Pediatr Res. 2011 May;69(5 Pt 2):55R-62R
references: 21289537
references: Curr Opin Neurol. 2013 Apr;26(2):146-53
references: 23406909
references: J Am Acad Child Adolesc Psychiatry. 2012 Jan;51(1):28-40.e3
references: 22176937
references: Autism Res. 2011 Apr;4(2):121-31
references: 21298812
references: Pediatrics. 2012 Nov;130(5):e1278-84
references: 23090336
references: J Autism Dev Disord. 2005 Jun;35(3):351-60
references: 16119476
references: Lancet. 1997 Dec 13;350(9093):1761-6
references: 9413479
references: Am J Psychiatry. 2013 Jan;170(1):59-70
references: 23111466
references: Am J Med Genet B Neuropsychiatr Genet. 2012 Jan;159B(1):5-12
references: 22095612
references: PLoS One. 2012;7(10):e47198
references: 23094036
references: Am J Psychiatry. 2012 Oct;169(10):1056-64
references: 23032385
references: Mol Psychiatry. 2012 Dec;17(12):1174-9
references: 22869033
references: J Child Psychol Psychiatry. 2012 May;53(5):490-509
references: 22486486
references: J Autism Dev Disord. 2012 Aug;42(8):1549-56
references: 22733300
references: J Child Psychol Psychiatry. 2006 Feb;47(2):167-75
references: 16423148
references: J Am Acad Child Adolesc Psychiatry. 2012 Aug;51(8):788-97
references: 22840550
references: J Autism Dev Disord. 2008 Oct;38(9):1731-9
references: 18408991
references: Dev Neurorehabil. 2012;15(3):185-90
references: 22582849
references: Mol Autism. 2010 Jun 17;1(1):10
references: 20678260
references: AJNR Am J Neuroradiol. 2012 Jan;33(1):83-9
references: 22173769
references: J Autism Dev Disord. 2012 Aug;42(8):1750-6
references: 22677932
references: J Intellect Disabil Res. 2009 Oct;53(10):852-73
references: 19708861
references: Arch Gen Psychiatry. 2011 Nov;68(11):1113-21
references: 22065527
references: Pediatrics. 2012 May;129(5):e1112-20
references: 22473372
references: PLoS Biol. 2011 Jun;9(6):e1001081
references: 21695109
references: J Autism Dev Disord. 2008 Sep;38(8):1414-25
references: 18240013
references: J Med Genet. 2009 Jan;46(1):1-8
references: 18728070
references: Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20195-200
references: 22123952
references: J Child Psychol Psychiatry. 2012 Oct;53(10):1092-4
references: 22970941
references: Arch Gen Psychiatry. 2012 Jan;69(1):46-52
references: 22213788
references: J Autism Dev Disord. 2001 Feb;31(1):5-17
references: 11439754
references: J Autism Dev Disord. 2008 Oct;38(9):1611-24
references: 18327636
references: Aust N Z J Psychiatry. 2002 Dec;36(6):762-70
references: 12406118
references: Curr Psychiatry Rep. 2013 Jan;15(1):334
references: 23250815
references: Curr Opin Neurobiol. 2007 Feb;17(1):103-11
references: 17275283
references: Am J Med Genet B Neuropsychiatr Genet. 2011 Apr;156B(3):255-74
references: 21438136
references: Neuropsychol Rev. 2008 Dec;18(4):305-19
references: 18956241
references: PLoS One. 2011;6(6):e20835
references: 21695147
references: J Autism Dev Disord. 2012 Sep;42(9):1810-7
references: 22806000
references: Curr Opin Genet Dev. 2012 Jun;22(3):229-37
references: 22463983