title: Gene expression of leptin and long leptin receptor isoform in endometriosis: a case-control study.
abstract: In this study, leptin/BMI ratio in serum and peritoneal fluid and gene expression of leptin and long form leptin receptor (OB-RL) were assessed in eutopic and ectopic endometria of women with endometriosis and controls. Increased serum leptin/BMI ratio was found in endometriosis patients. Leptin and OB-RL gene expression was significantly higher in ectopic versus eutopic endometrium of patients and controls. A positive, significant correlation was observed between leptin and OB-RL transcripts in ectopic endometria and also in eutopic endometria in endometriosis and control groups. A negative and significant correlation was found between OB-RL mRNA expression and peritoneal fluid leptin/BMI ratio only in endometriosis. These data suggest that, through a modulatory interaction with its active receptor, leptin might play a role in the development of endometrial implants.
authors: Gynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas de Porto Alegre (HCPA), Rua Ramiro Barcelos 2350, 90035-003 Porto Alegre, RS, Brazil ; Human Reproduction Unit, Hospital Fêmina, Grupo Hospitalar Conceição (GHC), Rua Mostardeiro 17, 90430-001 Porto Alegre, RS, Brazil.
authors: Andrea Prestes
authors: AP
authors: Nácul
authors: Sheila Bunecker
authors: SB
authors: Lecke
authors: Maria Isabel
authors: MI
authors: Edelweiss
authors: Débora Martinho
authors: DM
authors: Morsch
authors: Poli Mara
authors: PM
authors: Spritzer
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