title: Deja Vu: EGF receptors drive resistance to BRAF inhibitors.
abstract: The promise of personalized medicine is upon us, and in some cancers, targeted therapies are rapidly becoming the mainstay of treatment for selected patients based on their molecular profile. The protein kinase BRAF is a driver oncogene in both thyroid cancer and melanoma, but while drugs that target BRAF and its downstream signaling pathway are effective in melanoma, they are ineffective in thyroid cancer. In this issue of Cancer Discovery, Montero-Conde and colleagues investigate why thyroid cancer is resistant to BRAF inhibitors despite the presence of BRAF mutation.
authors: The University of Manchester, Manchester, UK.
authors: Maria Romina
authors: MR
authors: Girotti
authors: Richard
authors: R
authors: Marais
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors* / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D066246:ErbB Receptors; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
references: N Engl J Med. 2010 Aug 26;363(9):809-19
references: 20818844
references: Cancer Discov. 2013 Jan;3(1):52-67
references: 23239741
references: Nature. 2012 Jan 26;483(7387):100-3
references: 22281684
references: N Engl J Med. 2011 Jun 30;364(26):2507-16
references: 21639808
references: Nature. 2002 Jun 27;417(6892):949-54
references: 12068308
references: Cancer Discov. 2013 May;3(5):520-33
references: 23365119
references: Cancer Discov. 2012 Mar;2(3):227-35
references: 22448344
references: Lancet Oncol. 2012 Aug;13(8):782-9
references: 22805292
references: Lancet. 2012 Jul 28;380(9839):358-65
references: 22735384
references: Cancer Discov. 2013 Feb;3(2):158-67
references: 23242808
references: Clin Cancer Res. 2013 Apr 15;19(8):2257-64
references: 23444215
references: N Engl J Med. 2012 Nov;367(18):1694-703
references: 23020132
references: Clin Cancer Res. 2012 Apr 1;18(7):2056-65
references: 22241789