title: Free fatty acid oxidation in insulin resistance and obesity.
abstract: The growing worldwide epidemic of obesity and diabetes portends a significant increase in cardiovascular disease. Obesity is associated with insulin resistance, and there is growing evidence that these conditions independently increase the risk of heart failure. Changes in myocardial substrate utilization develop in obesity and insulin resistance, and are characterized by increased fatty acid oxidation and utilization, and decreased glucose utilization. This paper will review the evidence for altered myocardial fatty acid utilization in obesity and insulin resistance, review mechanisms that are responsible, and discuss the relative contributions of systemic and myocardial insulin resistance in the regulation of fatty acid utilization in the heart.
authors: Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
authors: E Dale
authors: ED
authors: Abel
keywords: Fatty acid oxidation; insulin resistance; myocardial substrate utilization; obesity
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