title: Effects of probiotics in periodontal diseases: a systematic review.
abstract: OBJECTIVE
  This study was designed to determine the effects of probiotics in prevention and/or treatment of periodontal diseases.
  
  
  METHODS
  We performed broad searches in the MEDLINE, Embase, and Cochrane databases and selected articles that satisfied the description of randomized clinical trials comparing the administration of probiotics versus placebo or another intervention to prevent or treat periodontal diseases in adult patients.
  
  
  RESULTS
  Four randomized clinical trials were analyzed in the final review process. For the primary outcome, probing pocket depth, there would be no clinical beneficial effect of probiotics. For secondary outcomes, probiotics have shown small benefits on plaque index and gingival inflammation.
  
  
  CONCLUSIONS
  Based on the results of this review, the effectiveness of probiotics on the prevention and treatment of periodontal diseases is questionable. There is currently insufficient evidence demonstrating the benefits of systematic preventative use of probiotics in patients with periodontal diseases.
  
  
  CONCLUSIONS
  The use of probiotics are described to prevent or treat periodontal diseases in some clinical trials; therefore, a systematic review of the evidence for the effect of periodontal diseases is needed.
authors: Evidence Based Dentistry Unit, School of Dentistry, Universidad de Chile, Sergio Livingstone 943 Independencia, Santiago, Chile. nyanine@u.uchile.cl
authors: Nicolás
authors: N
authors: Yanine
authors: Ignacio
authors: I
authors: Araya
authors: Romina
authors: R
authors: Brignardello-Petersen
authors: Alonso
authors: A
authors: Carrasco-Labra
authors: Almudena
authors: A
authors: González
authors: Arelis
authors: A
authors: Preciado
authors: Julio
authors: J
authors: Villanueva
authors: Mariano
authors: M
authors: Sanz
authors: Conchita
authors: C
authors: Martin
mesh_terms: D003774:Dental Plaque Index; D005891:Gingivitis / Q000188:drug therapy; D006801:Humans; D010510:Periodontal Diseases / Q000188:drug therapy*; D019936:Probiotics / Q000627:therapeutic use*
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