title: Whole-brain black-blood imaging with magnetization-transfer prepared spin echo-like contrast: a novel sequence for contrast-enhanced brain metastasis screening at 3T.
abstract: In contrast-enhanced (CE) brain metastasis screening, coexistence of enhanced blood vessel suppression and higher tumor-to-parenchyma contrast may improve radiologists' performances in detecting brain metastases compared with conventional sequences. In this study, we propose a new scheme, allowing both suppression of blood signals and improvement of tumor-to-parenchyma contrast, using motion-sensitized driven equilibrium prepared 3D low-refocusing flip-angle turbo spin echo (TSE) ("magnetization transfer prepared spin echo"-like contrast volume examination: MATLVE) for brain metastasis screening at 3.0 T, and we compare MATLVE to conventional three-dimensional (3D)-gradient recalled echo (GRE) and 3D-TSE sequences. With the use of MATLVE, the signal intensity of CE blood decreased substantially. Furthermore, the contrast ratio of tumor-to-white matter was significantly higher than in either conventional 3D-GRE or 3D-TSE. MATLVE can be used for 3D volumetric post-CE black-blood imaging, and it may be effective in detecting small brain metastases by selectively enhancing tumor signals while suppressing blood signals.
authors: Yaesu Clinic, C-road Bldg 4F, 2-1-18 Nihonbashi, Chuo-ku, Tokyo, Japan. yoneyama@m-satellite.jp
authors: Masami
authors: M
authors: Yoneyama
authors: Masanobu
authors: M
authors: Nakamura
authors: Takashi
authors: T
authors: Tabuchi
authors: Atsushi
authors: A
authors: Takemura
authors: Makoto
authors: M
authors: Obara
authors: Satoshi
authors: S
authors: Tatsuno
authors: Seishi
authors: S
authors: Sawano
mesh_terms: D000465:Algorithms; D001932:Brain Neoplasms / Q000097:blood / Q000175:diagnosis*; D003287:Contrast Media; D055088:Early Detection of Cancer; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D009362:Neoplasm Metastasis; D019047:Phantoms, Imaging; D059629:Signal-To-Noise Ratio; D013113:Spin Labels
chemical_list: D003287:Contrast Media; D013113:Spin Labels
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