title: Pseudolymphomatous cutaneous angiosarcoma: a report of 2 new cases arising in an unusual setting.
abstract: Pseudolymphomatous cutaneous angiosarcoma represents a rare, relatively new variant of cutaneous angiosarcoma exhibiting a prominent inflammatory lymphoid infiltrate that can mask the underlying vascular malignant proliferation and mimic a lymphomatous or pseudolymphomatous process. We describe the clinicopathologic characteristics of two new cases of pseudolymphomatous cutaneous angiosarcoma whose originality lies in the unusual setting from which they have arisen. In fact, the first case was an exceedingly lymphocyte-rich recurrence of a typical epithelioid cutaneous angiosarcoma whose primary lesion that was almost devoid of inflammatory infiltrate underwent surgical excision and radiotherapy while the second one was an unexpected histopathological finding associated with a basal cell carcinoma. Immunohistochemically, most of the lymphocytes expressed immunoreactivity for T-cell markers, while the neoplastic endothelial lymphatic cells expressed CD31 and CD34. D2-40 immunoreactivity was observed lining some channels and some neoplastic cells. In the first case a possible relationship between radiotherapy and the pseudolymphomatous reactive pattern is discussed while the second case has been considered as a rare example of collision tumor.
authors: Section of Dermatology, University of Genova, Genova, Italy; Department of Pathology, University of Genova, Genova, Italy. franco.rongioletti@unige.it
authors: Franco
authors: F
authors: Rongioletti
authors: Ann-Flore
authors: AF
authors: Albertini
authors: Valentina
authors: V
authors: Fausti
authors: Elisa
authors: E
authors: Cinotti
authors: Aurora
authors: A
authors: Parodi
authors: Silvie
authors: S
authors: Fraitag
mesh_terms: D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000378:metabolism*; D005260:Female; D006394:Hemangiosarcoma / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy
chemical_list: D018952:Antigens, CD34; D009363:Neoplasm Proteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1
keywords: collision tumor; cutaneous angiosarcoma; vascular neoplasm