title: Plasma surface modification of fibroporous polycarbonate urethane membrane by polydimethyl siloxane: structural characterization, mechanical properties, and in vitro cytocompatibility evaluation.
abstract: This article reports the surface modification of electrospun polycarbonate urethane membrane with polydimethyl siloxane (PDMS) using plasma-induced grafting technique for biomedical applications. The nonwoven membranes were characterized for their structure, performance, and compatibility with cells. The surface modification was confirmed by means of attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and energy dispersive X-ray analysis (EDXA). ATR-FTIR and EDXA analyses displayed characteristic absorption peaks of PDMS for the membrane. The structure and morphology of the developed membranes were studied using scanning electron microscope and microcomputed tomography (µCT). Scanning electron microscopy and µCT revealed the fibrous morphology and percentage porosity of the membranes before and after plasma modification. Static mechanical tests showed that the tensile strength was greater than 8 MPa. Physical characterization of the membranes after immersion in hydrolytic and oxidative media supports their biostability. Cytotoxicity of the membrane was evaluated using L929 fibroblast cells, and the results indicated that the membrane is cytocompatible. Accordingly, these results highlight the potential of this fibrous membrane for biomedical applications.
authors: Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojappura, Thiruvananthapuram, 695012, India.
authors: G N
authors: GN
authors: Arjun
authors: Girish
authors: G
authors: Menon
authors: P
authors: P
authors: Ramesh
mesh_terms: D000818:Animals; D016923:Cell Death; D002460:Cell Line; D002470:Cell Survival; D002555:Cerebrospinal Fluid / Q000737:chemistry; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D008422:Materials Testing / Q000379:methods*; D055595:Mechanical Phenomena; D008567:Membranes, Artificial; D051379:Mice; D008855:Microscopy, Electron, Scanning; D058626:Plasma Gases / Q000737:chemistry*; D011076:Polycarboxylate Cement / Q000737:chemistry*; D016062:Porosity; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014520:Urethane / Q000737:chemistry*; D017155:Wettability
chemical_list: D004129:Dimethylpolysiloxanes; D008567:Membranes, Artificial; D058626:Plasma Gases; D011076:Polycarboxylate Cement; C005506:polycarbonate; D014520:Urethane; C013830:baysilon
keywords: electrospinning; in vitro cytotoxicity; polycarbonate urethane; polydimethyl siloxane