title: Highly accelerated cardiac cine phase-contrast MRI using an undersampled radial acquisition and temporally constrained reconstruction.
abstract: OBJECTIVE
  To evaluate a method to enable single-slice or multiple-slice cine phase contrast (cine-PC) acquisition during a single breath-hold using a highly sparsified radial acquisition ordering and temporally constrained image reconstruction with a spatially varying temporal constraint.
  
  
  METHODS
  Simulated and in vivo cine-PC datasets of the proximal ascending aorta were obtained at different acceleration factors using a view projection acquisition order optimized for temporally constrained reconstruction (TCR). Reconstruction of the sparse cine-PC data performed with TCR was compared to reconstructions using zero-filled regridding and temporal interpolation.
  
  
  RESULTS
  TCR resulted in more accurate velocity measurements than regridding or temporal interpolation. In one dataset, TCR of undersampled in vivo data (16 views per cardiac phase) resulted in a peak systolic velocity within 3.3% of the value measured by Doppler ultrasound while shortening the scan time to 13 seconds. High temporal-resolution undersampled TCR was also compared lower temporal-resolution, more highly sampled, regridding in three normal volunteers.
  
  
  CONCLUSIONS
  TCR proved to be an effective method for reconstructing undersampled radial PC data. Although TCR utilizes a temporal constraint, temporal blurring was minimized by using appropriate constraint weights in addition to a spatially varying temporal constraint. TCR allowed for the acquisition time to be reduced to the duration of a breath-hold, while still resulting in accurate velocity measurements.
authors: Biomedical Informatics, University of Utah, Salt Lake City, Utah, USA; Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah, USA.
authors: Jordan P
authors: JP
authors: Hulet
authors: Andreas
authors: A
authors: Greiser
authors: Jason K
authors: JK
authors: Mendes
authors: Chris
authors: C
authors: McGann
authors: Gerald
authors: G
authors: Treiman
authors: Dennis L
authors: DL
authors: Parker
mesh_terms: D000465:Algorithms; D001011:Aorta / Q000473:pathology*; D016477:Artifacts; D062485:Breath Holding; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D018401:Sample Size; D012680:Sensitivity and Specificity
keywords: constrained reconstruction; iterative reconstruction; phase-contrast
references: Circulation. 1995 Aug 1;92(3):579-86
references: 7634472
references: Magn Reson Med. 2008 Nov;60(5):1169-77
references: 18958854
references: Magn Reson Med. 2010 Aug;64(2):472-80
references: 20665791
references: Radiology. 1989 Oct;173(1):255-63
references: 2781017
references: Magn Reson Med. 2007 Jun;57(6):1027-36
references: 17534924
references: Radiology. 1996 Mar;198(3):745-50
references: 8628864
references: J Comput Assist Tomogr. 1987 Sep-Oct;11(5):751-6
references: 3655038
references: Magn Reson Med. 1999 Mar;41(3):544-9
references: 10204878
references: Magn Reson Imaging. 2005 Sep;23(7):795-9
references: 16214610
references: J Cardiovasc Magn Reson. 2011 Jan 14;13:7
references: 21235751
references: Magn Reson Med. 2005 Dec;54(6):1430-8
references: 16276492
references: Magn Reson Med. 1988 Sep;8(1):25-34
references: 3050356
references: Magn Reson Med. 2001 Oct;46(4):638-51
references: 11590639
references: J Magn Reson Imaging. 2009 Feb;29(2):466-73
references: 19161204
references: J Magn Reson Imaging. 2009 Apr;29(4):817-24
references: 19306404