title: Non-invasive imaging of acute allograft rejection after rat renal transplantation using 18F-FDG PET.
abstract: The number of patients with end-stage renal disease, and the number of kidney allograft recipients continuously increases. Episodes of acute cellular allograft rejection (AR) are a negative prognostic factor for long-term allograft survival, and its timely diagnosis is crucial for allograft function (1). At present, AR can only be definitely diagnosed by core-needle biopsy, which, as an invasive method, bares significant risk of graft injury or even loss. Moreover, biopsies are not feasible in patients taking anticoagulant drugs and the limited sampling site of this technique may result in false negative results if the AR is focal or patchy. As a consequence, this gave rise to an ongoing search for new AR detection methods, which often has to be done in animals including the use of various transplantation models. Since the early 60s rat renal transplantation is a well-established experimental method for the examination and analysis of AR (2). We herein present in addition small animal positron emission tomography (PET) using (18)F-fluorodeoxyglucose (FDG) to assess AR in an allogeneic uninephrectomized rat renal transplantation model and propose graft FDG-PET imaging as a new option for a non-invasive, specific and early diagnosis of AR also for the human situation (3). Further, this method can be applied for follow-up to improve monitoring of transplant rejection (4).
authors: Department of Internal Medicine D, Experimental Nephrology, University of Münster. alexander.grabner@ukmuenster.de
authors: Alexander
authors: A
authors: Grabner
authors: Dominik
authors: D
authors: Kentrup
authors: Uta
authors: U
authors: Schnöckel
authors: Gert
authors: G
authors: Gabriëls
authors: Rita
authors: R
authors: Schröter
authors: Hermann
authors: H
authors: Pavenstädt
authors: Otmar
authors: O
authors: Schober
authors: Eberhard
authors: E
authors: Schlatter
authors: Michael
authors: M
authors: Schäfers
authors: Stefan
authors: S
authors: Reuter
mesh_terms: D000818:Animals; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006084:Graft Rejection / Q000000981:diagnostic imaging*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D051381:Rats; D011917:Rats, Inbred Lew; D019737:Transplants / Q000000981:diagnostic imaging
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
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