title: Fungal arachidonic acid-rich oil: research, development and industrialization.
abstract: Fungal arachidonic acid (ARA)-rich oil is an important microbial oil that affects diverse physiological processes that impact normal health and chronic disease. In this article, the historic developments and technological achievements in fungal ARA-rich oil production in the past several years are reviewed. The biochemistry of ARA, ARA-rich oil synthesis and the accumulation mechanism are first introduced. Subsequently, the fermentation and downstream technologies are summarized. Furthermore, progress in the industrial production of ARA-rich oil is discussed. Finally, guidelines for future studies of fungal ARA-rich oil production are proposed in light of the current progress, challenges and trends in the field.
authors: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology , Nanjing , People's Republic of China.
authors: Xiao-Jun
authors: XJ
authors: Ji
authors: Lu-Jing
authors: LJ
authors: Ren
authors: Zhi-Kui
authors: ZK
authors: Nie
authors: He
authors: H
authors: Huang
authors: Ping-Kai
authors: PK
authors: Ouyang
mesh_terms: D016718:Arachidonic Acid / Q000378:metabolism*; D005658:Fungi / Q000378:metabolism*; D007221:Industry; D009821:Oils / Q000378:metabolism*; D012106:Research
chemical_list: D009821:Oils; D016718:Arachidonic Acid
keywords: Arachidonic acid; Mortierella; industrialization; lipid accumulation; oleaginous fungi; polyunsaturated fatty acid; triacylglycerol