title: Reports of patients and relatives from the CogniCIS study about cognition in clinically isolated syndrome: what are our patients telling us?
abstract: OBJECTIVE
  To assess the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) in patients with clinically isolated syndrome (CIS).
  
  
  METHODS
  130 European CIS patients and 60 relatives completed the MSNQ.
  
  
  RESULTS
  The mean (SD) MSNQ score for CIS patients was 15.5 (10.8) and for their informants 11.3 (9.6). Neither the CIS patient nor relative MSNQ report scores correlated with any of the cognitive test scores in the Brief Repeatable Battery of Neuropsychological Tests, but they were significantly related to psychosocial scales including depression.
  
  
  CONCLUSIONS
  In CIS, patient and relative MSNQ scores are influenced by psychosocial variables rather than actual objective cognitive status. Formal cognitive test assessment is recommended for CIS patients.
authors: Royal Holloway, University of London, London, UK. d.langdon@rhul.ac.uk
authors: D W
authors: DW
authors: Langdon
authors: R H B
authors: RH
authors: Benedict
authors: E M
authors: EM
authors: Wicklein
authors: K
authors: K
authors: Beckmann
authors: S
authors: S
authors: Fredrikson
mesh_terms: D000328:Adult; D003071:Cognition; D003711:Demyelinating Diseases / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011584:Psychology