title: The influence of social support on hematopoietic stem cell transplantation survival: a systematic review of literature.
abstract: BACKGROUND
  Hematopoietic Stem cell Transplantation (HSCT) can negatively impact the psychosocial well-being of the patient. Social support is a complex term that has been variably used to encompass perceived and objective support, including caregiver presence. Social support has been associated with superior psychosocial outcomes; however the influence of social support on HSCT survival remains unclear. We sought to summarize the literature on the influence of social support on HSCT survival.
  
  
  METHODS
  MEDLINE, EMBASE, COCHRANE, CINAHL, AND PSYCINFO WERE SEARCHED USING THE FOLLOWING SEARCH CATEGORIES/CONCEPTS: 1) HSCT, 2) Social support, 3) Caregiver, 4) Survival, and 5) Treatment outcomes.
  
  
  RESULTS
  We identified 6 relevant studies: 4 publications, 1 dissertation, and 1 abstract. Three studies were retrospective and 3, prospective. Sample size ranged between 92-272 with a mean/median patient age between 30-55 yrs. The duration of follow-up ranged between 13.3-48 months. Social support was measured inconsistently: 2 by retrospective investigator assessment, 2 as patients' perceived support, 1 as caregiver presence, and 1 included caregiver presence and retrospective investigator assessment. The 4 published studies and 1 abstract demonstrate an association between better social support and survival. However, the unpublished dissertation, with the largest sample size found no association.
  
  
  CONCLUSIONS
  There is a paucity of evidence examining social support with HSCT survival. Available studies are older, with the most recent publication in 2005. A heterogeneous group of HSCT patients were studied with variable follow-up times. Further, covariates were variably considered in HSCT survival analyses and we suggest that there may be publication bias, given the negative unpublished study with the largest sample size. Prospective studies using validated scales are necessary to better assess the influence of social support on HSCT mortality. Given the potential for improved HSCT survival with better social support, HSCT centres should routinely provide HSCT recipients and their caregivers with enhanced psychosocial services.
authors: School of Psychology, University of Ottawa, Ottawa, Ontario, Canada. sbeat033@uottawa.ca
authors: Sara
authors: S
authors: Beattie
authors: Sophie
authors: S
authors: Lebel
authors: Jason
authors: J
authors: Tay
mesh_terms: D000328:Adult; D017028:Caregivers / Q000523:psychology; D018380:Hematopoietic Stem Cell Transplantation / Q000523:psychology*; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D012944:Social Support; D016019:Survival Analysis
references: Psychosomatics. 1991 Fall;32(4):420-5
references: 1961856
references: Best Pract Res Clin Haematol. 2007 Jun;20(2):119-24
references: 17448952
references: Psychosom Med. 2011 Nov-Dec;73(9):724-30
references: 22021459
references: Eur J Cancer Care (Engl). 1995 Sep;4(3):127-32
references: 7551422
references: Semin Hematol. 2012 Jan;49(1):104-9
references: 22221790
references: J Clin Oncol. 2000 Apr;18(7):1539-49
references: 10735903
references: Psychooncology. 2011 Nov;20(11):1137-50
references: 21425389
references: Biol Blood Marrow Transplant. 2010 Dec;16(12):1682-92
references: 20685400
references: Ann Intern Med. 1992 Dec 15;117(12):1003-9
references: 1443968
references: J Consult Clin Psychol. 2002 Feb;70(1):235-40
references: 11860050
references: Support Care Cancer. 2007 Jan;15(1):81-7
references: 17004090
references: Bone Marrow Transplant. 1994 May;13(5):589-96
references: 8054912
references: JAMA. 2004 May 19;291(19):2335-43
references: 15150205
references: Psychooncology. 2005 Sep;14(9):759-70
references: 15744779
references: Clin Transplant. 1998 Aug;12(4):320-3
references: 9686326
references: Bone Marrow Transplant. 1993 Apr;11(4):319-27
references: 8485479
references: Soc Work Health Care. 2011;50(10):815-27
references: 22136347
references: Psychol Bull. 1996 May;119(3):488-531
references: 8668748
references: J Clin Oncol. 2012 Aug 10;30(23):2885-90
references: 22802321
references: J Pers Assess. 1990 Winter;55(3-4):610-7
references: 2280326
references: J Psychosoc Oncol. 2007;25(1):87-101
references: 17360317
references: Int J Behav Med. 1999;6(3):241-54
references: 16250678