title: [The nucleolus of the cell is the site of iron accumulation in the substantia nigra neurons of the human brain].
abstract: Distribution of iron in the substantia nigra of the human brain (10 men and women aged 27-78 years) was studied using Perls' histochemical method. Iron ions were demonstrated in the nigral neuropil and melanin-containing neurons. For the first time the nuclei of some neurons were found to contain iron accumulations. The intranuclear iron inclusions correspond to the nucleolus according to their sharp outline and sizes. Detection of iron in the neuronal nucleolus may contribute to the understanding of mechanisms of iron neurotoxicity for nigral dopaminergic neurons.
authors: RAMS North-Western Branch Institute of Experimental Medicine, St. Petersburg, Russia
authors: Ye G
authors: YG
authors: Sukhorukova
authors: I P
authors: IP
authors: Grigoriev
authors: Ye A
authors: YA
authors: Kolos
authors: D E
authors: DE
authors: Korzhenevskiy
mesh_terms: D000328:Adult; D000368:Aged; D002466:Cell Nucleolus / Q000737:chemistry*; D005260:Female; D006801:Humans; D007501:Iron / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000737:chemistry*; D019581:Neuropil / Q000737:chemistry; D013378:Substantia Nigra / Q000737:chemistry* / Q000166:cytology
chemical_list: D007501:Iron