title: Primary breast lymphoma: a single institution's experience.
abstract: OBJECTIVE
  Primary breast lymphoma is a very rare disease, accounting for 0.4-0.5% of all breast malignancies. Due to the rarity, there are only limited reports of this disease in Korean women. In this reason, we report the experience of a single institution in Korea with primary breast lymphoma (PBL).
  
  
  METHODS
  We retrospectively reviewed the medical records of 9 patients with PBL and evaluated the clinicopathologic characteristics and treatment outcomes.
  
  
  RESULTS
  All nine patients were female and had diffuse large B-cell lymphoma (DLBL). The median age at diagnosis was 47.9 years and the median tumor size was 3.8 cm in diameter. The most common symptom was a painless palpable mass. Five patients were classified as stage IEA and four patients were IIEA according to the Ann Arbor staging system. Four patients underwent excisional biopsy and one patient underwent a lumpectomy with sentinel lymph node biopsy due to uncertain histology of the preoperative core needle biopsy. Nine patients received anthracycline containing combined chemotherapy; among them, five patients were treated with a rituximab containing regimen. Four patients received radiotherapy combined with chemotherapy. A complete response was achieved in eight patients. During the 44 months of the median follow-up period, three cases of relapse occurred, and among them, two patients died due to disease progression.
  
  
  CONCLUSIONS
  Most PBLs are B-cell origin, with DLBL being the most common histologic type. A combined treatment modality has been known to have positive effects on prognosis, and surgery should be limited to a diagnostic purpose.
authors: Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ; Division of Breast and Endocrine Surgery, Department of Surgery, Korea University Hospital, Korea University College of Medicine, Seoul, Korea.
authors: Seung Pil
authors: SP
authors: Jung
authors: Minkuk
authors: M
authors: Kim
authors: Kang Min
authors: KM
authors: Han
authors: Jung-Han
authors: JH
authors: Kim
authors: Jee Soo
authors: JS
authors: Kim
authors: Seok Jin
authors: SJ
authors: Nam
authors: Jeoung Won
authors: JW
authors: Bae
authors: Jeong Eon
authors: JE
authors: Lee
keywords: Breast; Combined modality therapy; Diffuse large B-cell lymphoma; Treatment outcome
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