title: An electrochemical Lab-on-a-CD system for parallel whole blood analysis.
abstract: Lab-on-a-CD, as a main branch of Lab-on-a-chip technology, has led to several very successful commercial products. Most of these existing Lab-on-a-CD systems present complex system designs and thus are relatively expensive. In this work, we have developed a simple but robust Lab-on-a-CD system for parallel whole blood analyses. This Lab-on-a-CD system incorporates electrochemical bioanalysis and a simple blood sample separation mechanism into the centrifugal platform, and thus reduces the system's complexity. To demonstrate the applicability, the system was applied to perform basic metabolic panel tests, for example, the concentrations of glucose, lactate and uric acids of whole blood samples. Using only 16 μL of whole blood, within a few minutes, the Lab-on-a-CD system could produce results that agreed in general with the data by a conventional system. Therefore, this proof-of-concept Lab-on-a-CD system has demonstrated the potential to become a robust and simple-to-use device for parallel blood analyses.
authors: Department of Mechanical and Materials Engineering, The University of Western Ontario, London, Ontario, N6A 5B9, Canada.
authors: Tingjie
authors: T
authors: Li
authors: Yaxi
authors: Y
authors: Fan
authors: Yang
authors: Y
authors: Cheng
authors: Jun
authors: J
authors: Yang
mesh_terms: D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis*; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D006801:Humans; D056656:Lab-On-A-Chip Devices; D019344:Lactic Acid / Q000097:blood*; D046210:Microfluidic Analytical Techniques; D014527:Uric Acid / Q000097:blood*
chemical_list: D001786:Blood Glucose; D014527:Uric Acid; D019344:Lactic Acid