title: CD4 testing at clinics to assess eligibility for antiretroviral therapy.
abstract: BACKGROUND
  In 2011, the Ministry of Health raised the CD4 threshold for antiretroviral therapy (ART) eligibility from <250 cells/µl and <350 cells/µl, but at the same time only 8.8% of facilities in Malawi with HIV services provided CD4 testing. We conducted a record review at 10 rural clinics in Thyolo District to assess the impact of introducing CD4 testing on identifying patients eligible for ART.
  
  
  METHODS
  We abstracted CD4 counts of all ART-naïve, HIV-infected patients with WHO clinical stages 1 and 2 and an initial CD4 test between May 2008 and June 2009. At four clinics, we also abstracted CD4 counts of patients not initially eligible for ART who were retested before April 2010.
  
  
  RESULTS
  Of 1,113 patients tested, the initial CD4 was "≤250 cells/µl" and "≤350 cells/µl" in 534 (48.0%). Of 203 patients with follow-up results, the most recent CD4 was ≤250 cells/µl in 34 (24.5%), and ≤350 cells/µl in 64 (46.0%).
  
  
  CONCLUSIONS
  CD4 testing in rural clinics is feasible and identifies many patients eligible for ART who would not be identified without CD4 testing. CD4 testing needs to be scaled-up to identify patients eligible for ART. ART services need to be scaled-up concurrently to meet the resulting increased demand.
authors: Médecins Sans Frontières, Thyolo, Malawi.
authors: Rumours
authors: R
authors: Lumala
authors: Thomas
authors: T
authors: van den Akker
authors: Carol Ann
authors: CA
authors: Metcalf
authors: Emma
authors: E
authors: Diggle
authors: Bote
authors: B
authors: Zamadenga
authors: Kingsley
authors: K
authors: Mbewa
authors: Ann
authors: A
authors: Akkeson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000553:Ambulatory Care / Q000379:methods; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D004608:Eligibility Determination / Q000379:methods*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D015276:Health Care Rationing / Q000379:methods; D006301:Health Services Needs and Demand; D006801:Humans; D008295:Malawi / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012424:Rural Population; D012959:Socioeconomic Factors; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents
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