title: Perceptual demand modulates activation of human auditory cortex in response to task-irrelevant sounds.
abstract: In the visual modality, perceptual demand on a goal-directed task has been shown to modulate the extent to which irrelevant information can be disregarded at a sensory-perceptual stage of processing. In the auditory modality, the effect of perceptual demand on neural representations of task-irrelevant sounds is unclear. We compared simultaneous ERPs and fMRI responses associated with task-irrelevant sounds across parametrically modulated perceptual task demands in a dichotic-listening paradigm. Participants performed a signal detection task in one ear (Attend ear) while ignoring task-irrelevant syllable sounds in the other ear (Ignore ear). Results revealed modulation of syllable processing by auditory perceptual demand in an ROI in middle left superior temporal gyrus and in negative ERP activity 130-230 msec post stimulus onset. Increasing the perceptual demand in the Attend ear was associated with a reduced neural response in both fMRI and ERP to task-irrelevant sounds. These findings are in support of a selection model whereby ongoing perceptual demands modulate task-irrelevant sound processing in auditory cortex.
authors: Department of Neurology, Medical College of Wisconsin, 8701Watertown Plank Road, Milwaukee, WI 53226, USA. msabri@mcw.edu
authors: Merav
authors: M
authors: Sabri
authors: Colin
authors: C
authors: Humphries
authors: Matthew
authors: M
authors: Verber
authors: Jain
authors: J
authors: Mangalathu
authors: Anjali
authors: A
authors: Desai
authors: Jeffrey R
authors: JR
authors: Binder
authors: Einat
authors: E
authors: Liebenthal
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000704:Analysis of Variance; D001303:Auditory Cortex / Q000098:blood supply / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D004007:Dichotic Listening Tests; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D011571:Psychoacoustics; D011930:Reaction Time / Q000502:physiology; D013016:Sound; D055815:Young Adult
chemical_list: D010100:Oxygen
references: Neuroimage. 2002 Apr;15(4):733-46
references: 11906217
references: J Exp Psychol Hum Percept Perform. 1995 Jun;21(3):451-68
references: 7790827
references: Psychol Rev. 1969 May;76(3):282-99
references: 4893203
references: J Neurosci. 2010 Jun 2;30(22):7604-12
references: 20519535
references: J Cogn Neurosci. 1990 Fall;2(4):344-57
references: 23964759
references: Psychophysiology. 1987 Jul;24(4):375-425
references: 3615753
references: Electroencephalogr Clin Neurophysiol. 1991 Sep;79(3):170-91
references: 1714809
references: Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6809-14
references: 15096618
references: Brain. 1996 Aug;119 ( Pt 4):1239-47
references: 8813286
references: Cereb Cortex. 2010 Dec;20(12):2958-70
references: 20382643
references: Curr Opin Otolaryngol Head Neck Surg. 2009 Oct;17(5):407-11
references: 19633556
references: J Exp Psychol Hum Percept Perform. 2011 Aug;37(4):1140-7
references: 21553997
references: Trends Cogn Sci. 2005 Feb;9(2):75-82
references: 15668100
references: Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):E505-14
references: 22308358
references: Percept Psychophys. 2003 Aug;65(6):888-900
references: 14528898
references: Psychol Rev. 1980 May;87(3):272-300
references: 7384344
references: Cereb Cortex. 2005 Oct;15(10):1621-31
references: 15703256
references: Science. 1997 Nov 28;278(5343):1616-9
references: 9374459
references: J Neurosci. 2003 Apr 15;23(8):3423-31
references: 12716950
references: Psychon Bull Rev. 2005 Aug;12(4):669-74
references: 16447380
references: Magn Reson Med. 1999 Dec;42(6):1014-8
references: 10571921
references: Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4182-7
references: 21368107
references: Open Neuroimag J. 2010;4:187-93
references: 21760872
references: Nat Neurosci. 2004 Sep;7(9):992-6
references: 15286791
references: Comput Biomed Res. 1996 Jun;29(3):162-73
references: 8812068
references: Hum Brain Mapp. 2009 Oct;30(10):3436-44
references: 19347876
references: Vision Res. 2010 Jun 18;50(13):1292-8
references: 20430048
references: Science. 1973 Oct 12;182(4108):177-80
references: 4730062
references: J Exp Psychol Hum Percept Perform. 1992 May;18(2):578-88; discussion 589-93
references: 1593236
references: Nat Neurosci. 2002 Nov;5(11):1203-9
references: 12379861
references: J Exp Psychol Hum Percept Perform. 1979 Feb;5(1):168-75
references: 528926
references: J Cogn Neurosci. 1989 Fall;1(4):336-55
references: 23971985
references: J Exp Psychol Gen. 2004 Sep;133(3):339-54
references: 15355143
references: Neuropsychologia. 1971 Mar;9(1):97-113
references: 5146491
references: Front Hum Neurosci. 2011 Apr 20;5:42
references: 21541252
references: Neuroimage. 2003 Dec;20(4):1944-54
references: 14683700
references: Brain Res Cogn Brain Res. 2002 Jun;14(1):64-74
references: 12063130
references: J Cogn Neurosci. 2006 May;18(5):689-700
references: 16768370
references: Cereb Cortex. 2005 Jun;15(6):770-86
references: 15459076
references: Nature. 1997 Jun 19;387(6635):808-10
references: 9194561
references: Science. 2001 Mar 2;291(5509):1803-6
references: 11230699
references: Biol Psychol. 1983 May-Jun;16(3-4):211-24
references: 6615954
references: Psychol Rev. 1963 Jan;70:80-90
references: 14027390
references: Audiol Neurootol. 1999 Mar-Apr;4(2):64-79
references: 9892757
references: Electroencephalogr Clin Neurophysiol. 1986 Sep;65(5):344-60
references: 2427326
references: Psychol Res. 2002 Nov;66(4):220-33
references: 12466921
references: Neuron. 2001 Jun;30(3):829-41
references: 11430815
references: J Exp Psychol Gen. 1985 Dec;114(4):472-97
references: 2934499
references: Percept Psychophys. 1994 Aug;56(2):183-97
references: 7971119
references: Neuroimage. 2009 Feb 1;44(3):839-48
references: 18976717
references: Brain Res Cogn Brain Res. 1998 Oct;7(2):99-109
references: 9774711