title: Body composition, glucose metabolism markers and serum androgens - association in women with polycystic ovary syndrome.
abstract: BACKGROUND
  To evaluate the association between abdominal and gynoid fat, glucose and lipid metabolism markers, and serum androgens in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Anthropometric measurements were performed in 40 women with PCOS aged 19-49 years with body mass index (BMI) 18.7-53.8 kg/m2. Fasting serum glucose, lipids, insulin, leptin, LH, FSH, oestradiol, androgens, SHGB and TSH were estimated. Body composition was measured by DEXA scan.
  
  
  RESULTS
  Four women (10%) were overweight, and 23 (57.5%) were obese. All subjects were hyperandrogenic (in 33 serum androgen levels were increased), and 16 of them were insulin resistant. All of the obese subjects had the abdominal type of obesity. Body weight, BMI, fat mass, fat mass of the trunk, abdominal and gynoidal fat mass correlated with serum triglyceride, glucose and insulin levels, and with HOMA index and blood pressure. Free androgen index (FAI) correlated with body weight (r = 0.43, p 〈 0.01), and BMI (r = 0.46, p 〈 0.05).
  
  
  CONCLUSIONS
  Using the DEXA method, we demonstrated abdominal type of obesity in all our obese subjects. There were positive significant correlations between fatness, lipids and glucose metabolism indices and blood pressure. Direct positive correlations between free androgen index, body weight and BMI were found.
authors: Department of Endocrinology, Medical Centre of Postgraduate Education, Bielański Hospital, Warsaw, Poland. kyaroslaw@tlen.pl
authors: Jarosław
authors: J
authors: Kozakowski
authors: Wojciech
authors: W
authors: Zgliczyński
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D000728:Androgens / Q000097:blood* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood* / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000378:metabolism; D012307:Risk Factors; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D000728:Androgens; D015415:Biomarkers; D001786:Blood Glucose