title: Interstitial radiosurgery with iodine-125 seeds in the treatment of brain metastases, glial tumours and benign intracranial lesions.
abstract: In a retrospective single-centre study, we analysed data of 1,378 patients (55 % male, 45 % female) who underwent interstitial radiotherapy with 1,596 implanted Iodine-125 seeds in the Department of Stereotactic and Functional Neurosurgery in Freiburg from January 1990 to December 2011. The medical prerequisites and physical parameters of the treatment with Iodine-125 seeds are given. The method used in Freiburg relying on temporary Iodine-125 seed implants is described in detail and analysed. The survival rates and the peri-operative risk are evaluated. We conclude that interstitial radiosurgery with Iodine-125 seeds is a safe and useful tool, offering a wide range of treatment options for benign and also malignant intracranial lesions, especially if they are small, deep-seated, in eloquent areas, or not suitable for micro-surgery.
authors: Division of Stereotactic and Functional Neurosurgery, Department of Neurosurgery, Neurosurgical Clinic, University Medical Center Freiburg, Breisacher Straße 64, Freiburg, D-79106, Germany, michael.trippel@uniklinik-freiburg.de.
authors: Michael
authors: M
authors: Trippel
authors: Thomas
authors: T
authors: Reithmeier
authors: Guido
authors: G
authors: Nikkhah
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D001921:Brain / Q000473:pathology* / Q000601:surgery; D001932:Brain Neoplasms / Q000178:diet therapy* / Q000401:mortality / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000473:pathology; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes