title: Female vulnerability to the development of depression-like behavior in a rat model of intimate partner violence is related to anxious temperament, coping responses, and amygdala vasopressin receptor 1a expression.
abstract: Exposure to violence is traumatic and an important source of mental health disturbance, yet the factors associated with victimization remain incompletely understood. The aim of the present study was to investigate factors related to vulnerability to depression-like behaviors in females. An animal model of intimate partner violence, which was previously shown to produce long-lasting behavioral effects in females as a result of male partner aggression, was used. The associations among the degree of partner aggression, the long-term consequences on depressive-like behavior, and the impact of the anxious temperament of the female were examined. In a separate group, pre-selected neural markers were evaluated in the amygdala and the lateral septum of females. Expression was examined by analyses of targeted candidate genes, serotonin transporter (slc6a4), vasopressin receptor 1a, (avpr1a), and oxytocin receptor (oxtr). Structural equation modeling revealed that the female's temperament moderated depressive-like behavior that was induced by cohabitation aggression from the male partner. More specifically, increased floating in the forced swim test following male aggression was most apparent in females exhibiting more anxiety-like behavior (i.e., less open arm exploration in an elevated plus-maze) prior to the cohabitation. Aggression reduced slc6a4 levels in the lateral septum. However, the interaction between partner aggression and the anxious temperament of the female affected the expression of avpr1a in the amygdala. Although, aggression reduced levels of this marker in females with high anxiety, no such pattern was observed in females with low anxiety. These results identify important characteristics in females that moderate the impact of male aggression. Furthermore, these results provide potential therapeutic targets of interest in the amygdala and the lateral septum to help improve post-stress behavioral pathology and increase resilience to social adversity.
authors: Laboratory of Behavioral Genetics, École Polytechnique Fédérale de Lausanne, Brain Mind Institute Lausanne, Switzerland.
authors: G L
authors: GL
authors: Poirier
authors: M I
authors: MI
authors: Cordero
authors: C
authors: C
authors: Sandi
keywords: anxiety; domestic violence; individual differences; resilience indicators; serotonin; social stress; vasopressin receptor subtype 1a; vulnerability indicators
references: J Neurosci. 2012 Sep 5;32(36):12499-505
references: 22956840
references: Ann N Y Acad Sci. 1999 Jun 29;877:242-57
references: 10415653
references: Neuroscience. 1981;6(4):557-618
references: 7017455
references: Genome Biol. 2007;8(2):R19
references: 17291332
references: Nat Neurosci. 2007 Sep;10(9):1103-9
references: 17726476
references: J Comp Neurol. 1997 Jul 7;383(3):305-25
references: 9205043
references: J Fam Psychol. 2004 Mar;18(1):82-96
references: 14992612
references: Eur J Neurosci. 2010 Mar;31(5):883-91
references: 20374286
references: Neuroscience. 2011 Sep 29;192:524-36
references: 21635938
references: Neurosci Biobehav Rev. 2005 Feb;29(1):3-38
references: 15652252
references: Philos Trans R Soc Lond B Biol Sci. 2013 Feb 25;368(1615):20110375
references: 23440461
references: Lancet. 2002 Apr 6;359(9313):1232-7
references: 11955557
references: Am J Med Genet B Neuropsychiatr Genet. 2007 Jan 5;144B(1):101-5
references: 16958039
references: PLoS One. 2012;7(6):e39501
references: 22745770
references: Trends Neurosci. 2012 Nov;35(11):649-59
references: 22974560
references: J Behav Ther Exp Psychiatry. 2009 Dec;40(4):544-57
references: 19726028
references: J Neurochem. 2010 Jan;112(2):397-409
references: 19878438
references: Biol Psychol. 2012 Oct;91(2):270-4
references: 22820037
references: Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17139-44
references: 18955705
references: Biol Psychiatry. 2010 Sep 1;68(5):405-7
references: 20591416
references: Psychopharmacology (Berl). 1989;97(2):183-8
references: 2498927
references: Depress Anxiety. 2011 Aug;28(8):639-47
references: 21608084
references: Neuropsychopharmacology. 2003 Jan;28(1):140-7
references: 12496950
references: BMC Physiol. 2008 Jul 21;8:16
references: 18644134
references: J Womens Health (Larchmt). 2007 Jul-Aug;16(6):822-32
references: 17678453
references: Science. 2002 Jul 19;297(5580):400-3
references: 12130784
references: Behav Genet. 2012 Jan;42(1):3-18
references: 21761238
references: Trends Neurosci. 2009 Jun;32(6):312-20
references: 19409624
references: J Neurosci. 1994 Sep;14(9):5381-92
references: 8083743
references: Scand J Psychol. 2008 Oct;49(5):447-50
references: 18452503
references: J Pers. 2002 Dec;70(6):925-64
references: 12498360
references: Transl Psychiatry. 2013 Jan 15;3:e216
references: 23321813
references: J Neurosci Methods. 1985 Aug;14(3):149-67
references: 2864480
references: Brain Res Brain Res Rev. 2004 Aug;46(1):71-117
references: 15297155
references: Stress. 2005 Dec;8(4):233-46
references: 16423712
references: J Psychiatry Neurosci. 2006 Jul;31(4):253-62
references: 16862243
references: Transl Psychiatry. 2012 Apr 24;2:e106
references: 22832906
references: J Neuroendocrinol. 2011 Nov;23(11):1113-24
references: 21929717
references: Arch Pediatr Adolesc Med. 2006 Mar;160(3):270-6
references: 16520446
references: Neurosci Biobehav Rev. 1999 Nov;23(7):925-35
references: 10580307
references: Genes Brain Behav. 2012 Apr;11(3):262-8
references: 22288734
references: Neuropharmacology. 2012 Feb;62(2):565-75
references: 21396383
references: Depress Anxiety. 2008;25(3):190-9
references: 17340601
references: Neuropsychopharmacology. 1997 Oct;17(4):284-92
references: 9326754
references: PLoS One. 2010 Jan 08;5(1):e8618
references: 20062812
references: Clin Child Fam Psychol Rev. 2007 Mar;10(1):53-100
references: 17318381
references: Soc Sci Med. 2012 Sep;75(6):959-75
references: 22694991
references: Trends Neurosci. 2012 Jan;35(1):24-35
references: 21798604
references: Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):16033-8
references: 17032778
references: Cell Mol Neurobiol. 2012 Jul;32(5):695-708
references: 22484834
references: Genes Brain Behav. 2007 Jul;6(5):453-64
references: 16965382
references: Neurosci Res. 2008 Jun;61(2):207-18
references: 18423675
references: Brain Res Brain Res Rev. 1997 Sep 19;24(2-3):115-95
references: 9385454
references: Nurs Res. 2005 Jul-Aug;54(4):235-42
references: 16027566
references: Eur J Pharmacol. 1978 Feb 15;47(4):379-91
references: 204499
references: J Pers Soc Psychol. 2003 Mar;84(3):558-68
references: 12635916
references: Front Neuroendocrinol. 2004 Sep-Dec;25(3-4):132-49
references: 15589266
references: Neurosci Biobehav Rev. 2005;29(4-5):829-41
references: 15893820
references: Am J Psychiatry. 2008 Aug;165(8):969-77
references: 18628348