title: Malignant diseases and mortality in blood donors infected with human T-lymphotropic virus type 1 in Israel.
abstract: OBJECTIVE
  The natural history of blood donors infected with human T-lymphotropic virus type 1 (HTLV-1) in Israel has never been assessed. The aim of this study was to evaluate the prevalence of malignant disorders and mortality among a cohort of Israelis diagnosed as HTLV-1 carriers during routine blood unit screening.
  
  
  METHODS
  This was an observational retrospective cohort study. All HTLV-1 cases among Israeli blood donors between 1995 and 2009 were included. Data regarding malignant diseases were extracted from the Israel National Cancer Registry. Mortality data were extracted from the Israel Population Registry.
  
  
  RESULTS
  Between January 9, 1995 and December 31, 2009, 1574497 blood donors were screened for HTLV-1 in the central blood bank services. Of these, 90 were found to be HTLV-1 carriers. This cohort of HTLV-1-infected blood donors was followed for an average of 9.2 ± 6 years. Among them six (6.7%) were diagnosed as having malignant diseases, four of them with adult T-cell leukemia/lymphoma (ATLL). The incidence of ATLL was 0.37 (95% confidence interval 0.13-1.08)/100 HTLV-1 carrier-years.
  
  
  CONCLUSIONS
  We found a high rate of malignant diseases among HTLV-1-infected blood donors.
authors: Department of Medicine C, Sheba Medical Center, Tel Hashomer, 52621 Israel; The Center of Geographic Medicine, Sheba Medical Center, Tel Hashomer, Israel; Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel. Electronic address: sshmuel@netvision.net.il.
authors: Shmuel
authors: S
authors: Stienlauf
authors: Vered
authors: V
authors: Yahalom
authors: Eilat
authors: E
authors: Shinar
authors: Yechezkel
authors: Y
authors: Sidi
authors: Gad
authors: G
authors: Segal
authors: Eli
authors: E
authors: Schwartz
mesh_terms: D000328:Adult; D001782:Blood Donors; D002353:Carrier State; D005260:Female; D005500:Follow-Up Studies; D015490:HTLV-I Infections / Q000150:complications*; D015368:Human T-lymphotropic virus 1; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000401:mortality*; D012189:Retrospective Studies
keywords: Adult T-cell leukemia/lymphoma; Blood banks; Epidemiology; HTLV-1 infections; Israel; Mortality