title: Oxidative status in rat kidney exposed to petroleum hydrocarbons.
abstract: OBJECTIVE
  The study investigates the possible role of oxidative stress on renal tissues in association with petroleum hydrocarbon-induced nephrotoxicity.
  
  
  METHODS
  Rats of comparable weights were randomly distributed into 10 groups: Control and groups exposed to kerosene, petrol, and diesel via inhalation, contamination by food, and contamination by water. The exposure lasted for eight weeks.
  
  
  RESULTS
  Exposure to petroleum hydrocarbon led to significant rise in serum urea and creatinine, and renal tissue malondialdehyde. It also caused significant reduction in urinary urea and creatinine, and reduced glutathione, superoxide dismutase, and catalase activities of renal tissue homogenate. However, serum and urine concentrations of albumin and total protein were comparable in all groups.
  
  
  CONCLUSIONS
  Results from this study shows that exposure to petroleum hydrocarbon led to renal dysfunction via oxidative stress, increasing lipid peroxidation and reducing the antioxidant defense mechanism.
authors: Department of Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Kwara state, Nigeria.
authors: Oyebisi M
authors: OM
authors: Azeez
authors: Roland E
authors: RE
authors: Akhigbe
authors: Chikodi N
authors: CN
authors: Anigbogu
keywords: Diesel; kerosene; oxidative stress; petrol; renal function
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