title: Genetic polymorphism of the kinesin-like protein KIF1B gene and the risk of hepatocellular carcinoma.
abstract: BACKGROUND
  Frequent deletions of the kinesin-like protein gene 1B (KIF1B) have been reported in neural tumors. Recently, a genome-wide association study revealed an association between polymorphisms in the KIF1B gene and the risk of hepatocellular carcinoma (HCC), and several case-control studies have further investigated this relationship. However, these studies have yielded controversial results. We therefore performed a meta-analysis to derive a more precise estimation of the association between the KIF1B gene polymorphisms and HCC risk.
  
  
  RESULTS
  PubMed, EMBASE, the ISI Web of Science and the CNKI databases were systematically searched to identify relevant studies. A total of 5 studies containing 13 cohorts with 5,773 cases and 6,404 controls were included. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the associations. Subgroup analyses were conducted based on ethnicities, sample sizes and quality scores. Overall, the G allele at rs17401966 of the KIF1B gene was associated with a significantly decreased risk for HCC (OR = 0.81, 95%CI: 0.70-0.93; P = 0.003). Furthermore, subgroup analyses showed that the G allele at rs17401966 of the KIF1B gene significantly reduced the risk for HCC in Chinese cohorts (OR = 0.76, 95%CI: 0.64-0.90; P = 0.002), large-sample-size cohorts (OR = 0.80, 95%CI: 0.73-0.88, P<0.01) and high-quality cohorts (OR = 0.78, 95%CI: 0.71-0.87, P<0.01). However, no significant associations were found in small-sample-size cohorts, studies with low-quality scores and when excluding the cohorts from the study reporting the original discovery.
  
  
  CONCLUSIONS
  These findings demonstrate that the presence of the G allele at rs17401966 of the KIF1B gene may decrease the risk for HCC and suggest that KIF1B may play a critical role in the development of HCC. High-quality studies with larger sample sizes and different ethnic populations will be of great value to further confirm these findings.
authors: Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, PR China.
authors: Zhi-Chao
authors: ZC
authors: Wang
authors: Qiang
authors: Q
authors: Gao
authors: Jie-Yi
authors: JY
authors: Shi
authors: Liu-Xiao
authors: LX
authors: Yang
authors: Jian
authors: J
authors: Zhou
authors: Xiao-Ying
authors: XY
authors: Wang
authors: Ying-Hong
authors: YH
authors: Shi
authors: Ai-Wu
authors: AW
authors: Ke
authors: Guo-Ming
authors: GM
authors: Shi
authors: Zhen-Bin
authors: ZB
authors: Ding
authors: Zhi
authors: Z
authors: Dai
authors: Shuang-Jian
authors: SJ
authors: Qiu
authors: Jia
authors: J
authors: Fan
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000201:enzymology* / Q000235:genetics*; D015331:Cohort Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016547:Kinesins / Q000235:genetics*; D008113:Liver Neoplasms / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C091053:KIF1B protein, human; D016547:Kinesins
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