title: Improvement of the oral bioavailability of coenzyme Q10 with lecithin nanocapsules.
abstract: Coenzyme Q10-loaded lecithin nanocapsules (CoQ10-LNCs), composed of a CoQ10/lecithin/ GTCC/glycerol aqueous solution, were prepared by high-pressure homogenization. The zeta potential of the CoQ10-LNCs above -60 mV was determined on a Malvern Zetasize 2000 (Malvern Instruments, UK). The spherical shape of the CoQ10-LNCs was observed by using freeze-fracture transmission electron microscopy (FF-TEM), and the particle size was found to be below 100 nm. The supercooled state of the CoQ10-LNCs was observed by differential scanning calorimetry (DSC). In an oral bioavailability study, the CoQ10 plasma level after administering CoQ10-LNCs was higher than that after administering a CoQ10 tablet over 24 hours, and the relative bioavailability of CoQ10 was improved to 176.6% in mice. Based on the above results, the LNC delivery system might be a potential vehicle for improving the oral bioavailability of CoQ10.
authors: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors: Huafeng
authors: H
authors: Zhou
authors: Jing
authors: J
authors: Zhang
authors: Yingfang
authors: Y
authors: Long
authors: Guoqing
authors: G
authors: Liu
authors: Mingxing
authors: M
authors: Duan
authors: Qiang
authors: Q
authors: Xia
mesh_terms: D000818:Animals; D001682:Biological Availability; D054709:Lecithins / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D009055:Mouth / Q000378:metabolism*; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry*; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D054709:Lecithins; D053769:Nanocapsules; D014451:Ubiquinone; C024989:coenzyme Q10