title: Five new flavonoid glycosides from Nervilia fordii.
abstract: Five new flavonoid glycosides, namely nervilifordins F-J (1-5), were isolated from the 60% EtOH extract of the aerial parts of Nervilia fordii, along with three first isolated flavonoids (7, 8, and 13) and five known flavonoids (6, 9-12). The structures of new compounds were elucidated on the basis of 1D and 2D NMR and MS studies. Their anti-inflammatory activities were tested by measuring their inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages. Compounds 2 and 5 showed interesting inhibition effects with their EC50 values of 15.15 μM and 14.80 μM, respectively.
authors: Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China.
authors: Li
authors: L
authors: Qiu
authors: Yang
authors: Y
authors: Jiao
authors: Ji-Zhao
authors: JZ
authors: Xie
authors: Gui-Kun
authors: GK
authors: Huang
authors: Shao-Ling
authors: SL
authors: Qiu
authors: Jian-Hua
authors: JH
authors: Miao
authors: Xin-Sheng
authors: XS
authors: Yao
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D029595:Orchidaceae / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D006027:Glycosides; D008070:Lipopolysaccharides; D009569:Nitric Oxide; C041477:3-hydroxyflavone