title: Nonsteroidal anti-inflammatory drug-induced severe hyponatremia.
abstract: Hyponatremia (serum sodium level, <135 mmol/L) occasionally may develop in the course of treatment with nonsteroidal anti-inflammatory drugs, which are usually used in daily clinical practice. Nonsteroidal anti-inflammatory drugs diminish the normal inhibitory effect of prostaglandins on the activity of antidiuretic hormone and can therefore reduce free water excretion, leading to water retention and induction or exacerbation of hyponatremia. In this report, we present a case of hyponatremia in a 78-year-old man who had received meloxicam, a nonsteroidal anti-inflammatory drug.
authors: Department of Nephrology, School of Medicine, Harran University, 63300 Şanliurfa, Turkey. demirmehmetemin@hotmail.com
authors: Mehmet Emin
authors: ME
authors: Demir
authors: Mehmet
authors: M
authors: Horoz
authors: Turgay
authors: T
authors: Ulas
authors: Mehmet Ali
authors: MA
authors: Eren
authors: Zafer
authors: Z
authors: Ercan
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001416:Back Pain / Q000188:drug therapy*; D059350:Chronic Pain / Q000188:drug therapy*; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D000077239:Meloxicam; D012964:Sodium / Q000097:blood; D013843:Thiazines / Q000008:administration & dosage / Q000009:adverse effects*; D013844:Thiazoles / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D012964:Sodium; D000077239:Meloxicam