title: Whole genome scanning and association mapping identified a significant association between growth and a SNP in the IFABP-a gene of the Asian seabass.
abstract: BACKGROUND
  Aquaculture is the quickest growing sector in agriculture. However, QTL for important traits have been only identified in a few aquaculture species. We conducted QTL mapping for growth traits in an Asian seabass F(2) family with 359 individuals using 123 microsatellites and 22 SNPs, and performed association mapping in four populations with 881 individuals.
  
  
  RESULTS
  Twelve and nine significant QTL, as well as 14 and 10 suggestive QTL were detected for growth traits at six and nine months post hatch, respectively. These QTL explained 0.9-12.0% of the phenotypic variance. For body weight, two QTL intervals at two stages were overlapped while the others were mapped onto different positions. The IFABP-a gene located in a significant QTL interval for growth on LG5 was cloned and characterized. A SNP in exon 3 of the gene was significantly associated with growth traits in different populations.
  
  
  CONCLUSIONS
  The results of QTL mapping for growth traits suggest that growth at different stages was controlled by some common QTL and some different QTL. Positional candidate genes and association mapping suggest that the IFABP-a is a strong candidate gene for growth. Our data supply a basis for fine mapping QTL, marker-assisted selection and further detailed analysis of the functions of the IFABP-a gene in fish growth.
authors: Molecular Population Genetics Group, Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, 117604 Singapore, Singapore.
authors: Jun Hong
authors: JH
authors: Xia
authors: Grace
authors: G
authors: Lin
authors: Xiaoping
authors: X
authors: He
authors: Peng
authors: P
authors: Liu
authors: Feng
authors: F
authors: Liu
authors: Fei
authors: F
authors: Sun
authors: Rongjian
authors: R
authors: Tu
authors: Gen Hua
authors: GH
authors: Yue
mesh_terms: D000818:Animals; D001492:Bass / Q000235:genetics* / Q000254:growth & development*; D005215:Fasting / Q000502:physiology; D050556:Fatty Acid-Binding Proteins / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D016678:Genome; D008297:Male; D018895:Microsatellite Repeats; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci
chemical_list: D050556:Fatty Acid-Binding Proteins
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