title: Ultrafast localized two-dimensional magnetic resonance correlated spectroscopy via spatially encoded technique.
abstract: OBJECTIVE
  To speed up acquisition of localized two-dimensional (2D) correlated spectroscopy (LCOSY).
  
  
  METHODS
  A new pulse sequence, dubbed as spatially encoded localized COSY (SLCOSY), based on spatially encoded technique, was developed for localized 2D correlated spectroscopy. It can be used to collect a full 2D spectrum in a single scan and thus on a subsecond timescale.
  
  
  RESULTS
  SLCOSY spectrum of a two-compartment phantom was obtained with a total acquisition time of 773 ms, with its volume localization confirmed. Localized 2D COSY spectrum of a proton magnetic resonance spectroscopy brain phantom within 12 s shows the ability of SLCOSY to detect the metabolites at physiological concentrations. All 10 constituent metabolites in this phantom are reliably detected. SLCOSY spectrum of a sample of pig brain tissue with the acquisition time of 32 s demonstrates the feasibility of SLCOSY for the detection of biological tissues. Twelve pairs of cross peaks are identified.
  
  
  CONCLUSIONS
  The new method proposed herein enables ultrafast collection of a full 2D COSY spectrum, and it can also be used for fast in vivo analysis of metabolites, when signal-to-noise ratio is not a limiting factor.
authors: Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, China.
authors: Yanqin
authors: Y
authors: Lin
authors: Qinta
authors: Q
authors: Zhang
authors: Zhiliang
authors: Z
authors: Wei
authors: Shuhui
authors: S
authors: Cai
authors: Jianhui
authors: J
authors: Zhong
authors: Zhong
authors: Z
authors: Chen
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D013223:Statistics as Topic; D013552:Swine; D014018:Tissue Distribution