title: Aortic arterial stiffness is a moderate predictor of cardiovascular disease in patients with psoriasis vulgaris.
abstract: Psoriasis is associated with an increased risk of atherosclerosis. Endothelial dysfunction is the critical early step in the process of atherogenesis, and it is commonly investigated by measuring arterial stiffness. We aimed to investigate the relationship between arterial stiffness and high-sensitivity C-reactive protein (hsCRP) in patients with psoriasis. A total of 32 patients with psoriasis and 35 patients with other skin diseases were included in the study. The hsCRP levels and arterial stiffness measurements were compared. Arterial stiffness was significantly different between the 2 groups (P = .01). Arterial stiffness was not associated with the duration of the disease or the disease activity (P = .34 and .64, respectively). In patients with psoriasis, arterial stiffness correlated positively with age, sex, body mass index, diastolic blood pressure, and hsCRP level (P < .05). These findings provide further evidence of a link between inflammation, premature atherosclerosis, and psoriasis.
authors: 1Department of Dermatology, Kecioren Training and Research Hospital, Ankara, Turkey.
authors: Ilknur
authors: I
authors: Balta
authors: Sevket
authors: S
authors: Balta
authors: Sait
authors: S
authors: Demirkol
authors: Turgay
authors: T
authors: Celik
authors: Ozlem
authors: O
authors: Ekiz
authors: Mustafa
authors: M
authors: Cakar
authors: Hakan
authors: H
authors: Sarlak
authors: Pinar
authors: P
authors: Ozoguz
authors: Atila
authors: A
authors: Iyisoy
mesh_terms: D000293:Adolescent; D000328:Adult; D050197:Atherosclerosis / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood / Q000503:physiopathology*; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein
keywords: arterial stiffness; atherosclerosis; endothelial dysfunction; high-sensitivity C-reactive protein; psoriasis