title: Large-area versus small-area application of mitomycin C during trabeculectomy.
abstract: OBJECTIVE
  To compare 2 different application methods of mitomycin C (MMC) in patients undergoing trabeculectomy.
  
  
  METHODS
  This retrospective trial compared outcomes of 191 eyes that underwent trabeculectomy with small-area (96 eyes; 50.3%) and large-area (95 eyes; 49.7%) MMC application. Main outcome measures were changes in intraocular pressure (IOP), required glaucoma medications, the frequency of complications, and postsurgical interventions.
  
  
  RESULTS
  Within both treatment groups, a highly significant IOP reduction was seen during follow-up (p < 0.0001). Statistical analyses revealed a significant difference in IOP between both groups. Patients treated with a larger size of surface area had a higher IOP reduction within the first postoperative year. Choroidal detachment, shallow anterior chamber, and bleb leak were seen more often in the large-area group with more aggressive MMC use. In contrast, complications associated with bleb failure such as bleb scarring were higher in the small-area group. Success rate was higher in the large-area MMC application group after 12 months.
  
  
  CONCLUSIONS
  Large-area treatment seems to be a more efficient application method of MMC during trabeculectomy.
authors: Department of Ophthalmology, University of Wuerzburg, Josef-Schneider-Strasse 11, Wuerzburg, Germany. j.matlach@augenklinik.uni-wuerzburg.de
authors: Juliane
authors: J
authors: Matlach
authors: Ermioni
authors: E
authors: Panidou
authors: Franz
authors: F
authors: Grehn
authors: Thomas
authors: T
authors: Klink
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D011183:Postoperative Complications; D012189:Retrospective Studies; D014130:Trabeculectomy / Q000379:methods*
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin