title: Mixture and odorant processing in the olfactory systems of insects: a comparative perspective.
abstract: Natural olfactory stimuli are often complex mixtures of volatiles, of which the identities and ratios of constituents are important for odor-mediated behaviors. Despite this importance, the mechanism by which the olfactory system processes this complex information remains an area of active study. In this review, we describe recent progress in how odorants and mixtures are processed in the brain of insects. We use a comparative approach toward contrasting olfactory coding and the behavioral efficacy of mixtures in different insect species, and organize these topics around four sections: (1) Examples of the behavioral efficacy of odor mixtures and the olfactory environment; (2) mixture processing in the periphery; (3) mixture coding in the antennal lobe; and (4) evolutionary implications and adaptations for olfactory processing. We also include pertinent background information about the processing of individual odorants and comparative differences in wiring and anatomy, as these topics have been richly investigated and inform the processing of mixtures in the insect olfactory system. Finally, we describe exciting studies that have begun to elucidate the role of the processing of complex olfactory information in evolution and speciation.
authors: Department of Biology, University of Washington, Seattle, WA, 98195, USA, cliffmar@u.washington.edu.
authors: Marie R
authors: MR
authors: Clifford
authors: Jeffrey A
authors: JA
authors: Riffell
mesh_terms: D000818:Animals; D005075:Biological Evolution; D007313:Insecta / Q000033:anatomy & histology / Q000502:physiology*; D009812:Odorants; D009833:Olfactory Pathways / Q000502:physiology*; D012903:Smell
references: Cell Mol Life Sci. 2006 Jul;63(14):1579-85
references: 16786219
references: Curr Biol. 2009 Feb 24;19(4):335-40
references: 19230669
references: Cell Tissue Res. 1992 Nov;270(2):205-27
references: 1451169
references: Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):12987-95
references: 21746926
references: J Comp Neurol. 2012 Mar 1;520(4):694-716
references: 21826660
references: Eur J Neurosci. 2007 Sep;26(5):1227-41
references: 17767501
references: Naturwissenschaften. 2010 Dec;97(12):1059-66
references: 20972770
references: Eur J Neurosci. 2012 Jun;35(11):1718-24
references: 22515321
references: Chem Senses. 2009 Nov;34(9):763-74
references: 19770215
references: J Neurosci. 2003 Nov 19;23(33):10495-502
references: 14627633
references: J Neurosci. 2007 Oct 31;27(44):11966-77
references: 17978037
references: Nat Rev Neurosci. 2002 Nov;3(11):884-95
references: 12415296
references: J Chem Ecol. 1986 May;12(5):989-1011
references: 24307043
references: J Comp Physiol A. 1998 Jun;182(6):703-14
references: 9631552
references: PLoS Biol. 2007 May;5(5):e118
references: 17456006
references: Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19219-26
references: 19907000
references: Prog Neurobiol. 2011 Nov;95(3):427-47
references: 21963552
references: Brain Behav Evol. 2001 Jan;57(1):1-17
references: 11359044
references: J Neurosci. 1999 Oct 1;19(19):8172-81
references: 10493719
references: Annu Rev Entomol. 2008;53:523-42
references: 17877458
references: Behav Genet. 2005 May;35(3):279-95
references: 15864443
references: Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5058-63
references: 15037749
references: Brain Res. 1984 May 23;300(2):311-9
references: 6145501
references: Neuron. 2011 Dec 8;72(5):698-711
references: 22153368
references: Physiol Behav. 1997 Jul;62(1):169-74
references: 9226358
references: Curr Opin Plant Biol. 2006 Aug;9(4):428-35
references: 16713328
references: J Neurobiol. 1996 May;30(1):92-109
references: 8727986
references: Chem Senses. 1998 Jun;23(3):269-81
references: 9669040
references: Science. 2003 Oct 17;302(5644):437-8
references: 14564006
references: J Neurophysiol. 2012 Jul;108(2):539-50
references: 22552185
references: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2005 Feb;191(2):105-14
references: 15711966
references: Neuron. 2004 May 13;42(3):437-49
references: 15134640
references: Nature. 2008 Apr 24;452(7190):956-60
references: 18344978
references: J Neurosci. 2009 Jul 1;29(26):8595-603
references: 19571150
references: J Neurophysiol. 2002 Feb;87(2):1106-17
references: 11826074
references: Proc Natl Acad Sci U S A. 2003 Nov 25;100 Suppl 2:14537-42
references: 14608037
references: Annu Rev Entomol. 2008;53:179-90
references: 18067443
references: Dev Neurobiol. 2007 May;67(6):764-77
references: 17443823
references: Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):8022-7
references: 8755596
references: Annu Rev Neurosci. 2006;29:163-201
references: 16776583
references: Microsc Res Tech. 2002 Feb 15;56(4):281-91
references: 11877803
references: J Chem Ecol. 2008 Jul;34(7):837-53
references: 18548311
references: Science. 2002 Jul 19;297(5580):359-65
references: 12130775
references: J Neurophysiol. 2010 Apr;103(4):2185-94
references: 20181736
references: Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5075-80
references: 21383179
references: PLoS One. 2011;6(10):e26443
references: 22028879
references: Chem Senses. 2013 May;38(4):293-304
references: 23315042
references: Curr Opin Neurobiol. 2008 Aug;18(4):408-12
references: 18809492
references: J Neurobiol. 1999 Mar;38(4):521-41
references: 10084687
references: J Exp Biol. 2012 May 15;215(Pt 10):1670-80
references: 22539734
references: PLoS One. 2010 Feb 08;5(2):e9110
references: 20161714
references: Annu Rev Neurosci. 1997;20:595-631
references: 9056726
references: J Neurophysiol. 2008 May;99(5):2077-85
references: 18322001
references: Physiol Behav. 1991 Mar;49(3):591-601
references: 2062938
references: J Neurosci. 2013 Feb 6;33(6):2443-56
references: 23392673
references: J Insect Physiol. 2012 May;58(5):743-9
references: 22414536
references: Science. 1996 Nov 8;274(5289):976-9
references: 8875938
references: J Comp Neurol. 1987 Jan 8;255(2):196-207
references: 3819014
references: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2012 Feb;198(2):159-71
references: 22083110
references: J Insect Physiol. 2007 May;53(5):399-410
references: 17379239
references: Cell Tissue Res. 1994 Jan;275(1):3-26
references: 8118845
references: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2006 Mar;192(3):279-88
references: 16315069
references: J Comp Neurol. 2005 Oct 17;491(2):141-56
references: 16127689
references: PLoS One. 2012;7(3):e33159
references: 22427979
references: Cell Tissue Res. 1998 Mar;291(3):525-36
references: 9477309
references: Annu Rev Neurosci. 2007;30:505-33
references: 17506643
references: Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11490-3
references: 14504399
references: Neuron. 2010 Sep 23;67(6):1034-47
references: 20869599
references: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2013 Nov;199(11):981-96
references: 23609840
references: Annu Rev Entomol. 2010;55:399-420
references: 19737085
references: J Exp Biol. 2010 Apr;213(Pt 8):1272-80
references: 20348339
references: Genome Res. 2006 Nov;16(11):1395-403
references: 17065611
references: J Comp Neurol. 2005 Dec 12;493(2):207-40
references: 16255032
references: J Chem Ecol. 2008 Jul;34(7):882-97
references: 18535862
references: Behav Neurosci. 2003 Apr;117(2):236-45
references: 12708520
references: Med Vet Entomol. 2002 Mar;16(1):91-8
references: 11963986
references: Chem Senses. 2011 Jan;36(2):209-20
references: 21059697
references: Nat Neurosci. 2010 Apr;13(4):439-49
references: 20139975
references: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2006 Mar;192(3):289-300
references: 16315070
references: J Exp Biol. 2010 Oct 1;213(Pt 19):3332-9
references: 20833926
references: Evolution. 2000 Dec;54(6):1995-2006
references: 11209776
references: J Neurosci. 2005 Oct 5;25(40):9069-79
references: 16207866
references: Chem Senses. 2003 May;28(4):325-38
references: 12771019
references: Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11826-31
references: 17596338
references: J Neurosci. 2008 Dec 3;28(49):13075-87
references: 19052198
references: J Neurophysiol. 1991 Jul;66(1):112-30
references: 1919661
references: Acta Biol Hung. 2004;55(1-4):21-9
references: 15270215
references: Science. 2013 Jan 11;339(6116):200-4
references: 23223454
references: Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10476-81
references: 15232007
references: J Chem Ecol. 1985 Dec;11(12):1747-56
references: 24311338
references: J Mol Histol. 2012 Aug;43(4):401-4
references: 22430182
references: Physiol Behav. 2000 Apr 1-15;69(1-2):203-9
references: 10854930
references: Nat Neurosci. 2002 Jun;5(6):557-65
references: 12006983
references: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2002 May;188(4):325-33
references: 12012103
references: Evolution. 2012 Nov;66(11):3632-41
references: 23106724
references: J Exp Biol. 2010 Dec 15;213(Pt 24):4291-303
references: 21113011
references: Science. 2007 Jul 20;317(5836):384-6
references: 17641204
references: Chem Senses. 2011 Sep;36(7):613-21
references: 21486995
references: Neuron. 2009 Dec 10;64(5):692-706
references: 20005825
references: J Exp Biol. 2010 Apr;213(Pt 7):1100-6
references: 20228346
references: PLoS Biol. 2006 Feb;4(2):e20
references: 16402857
references: Neuron. 2007 Apr 5;54(1):89-103
references: 17408580
references: PLoS Comput Biol. 2012;8(7):e1002563
references: 22807661
references: Neuron. 2001 May;30(2):537-52
references: 11395013
references: Annu Rev Entomol. 2008;53:161-78
references: 17803457
references: Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13621-6
references: 12237399
references: Genetics. 1998 Aug;149(4):1899-908
references: 9691045
references: J Exp Biol. 2006 Oct;209(Pt 19):3729-41
references: 16985190
references: J Neurosci. 2006 Aug 23;26(34):8727-33
references: 16928861
references: Proc Biol Sci. 2007 Jun 22;274(1617):1539-46
references: 17439855
references: Nature. 2012 Dec 6;492(7427):66-71
references: 23172146
references: Nat Neurosci. 2007 Nov;10(11):1474-82
references: 17922008
references: J Chem Ecol. 2008 Jul;34(7):915-27
references: 18581181
references: Curr Biol. 2007 Apr 3;17(7):599-605
references: 17363250
references: Chem Senses. 2006 Nov;31(9):845-63
references: 16963500
references: Prog Neurobiol. 2010 Sep;92(1):42-104
references: 20447440
references: Eur J Neurosci. 2006 Aug;24(4):1161-74
references: 16930442
references: J Chem Ecol. 2008 Jul;34(7):971-81
references: 18452043
references: J Neurophysiol. 2005 Jun;93(6):3410-7
references: 15673548
references: BMC Evol Biol. 2010 Sep 16;10:286
references: 20846426
references: Curr Biol. 2006 Jan 10;16(1):101-9
references: 16401429
references: Learn Mem. 2002 May-Jun;9(3):112-21
references: 12074999
references: Front Neural Circuits. 2011 May 11;5:7
references: 21772814
references: Nature. 2006 Nov 16;444(7117):295-301
references: 17108953
references: Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20285-9
references: 18077325
references: J Neurosci. 2011 Feb 23;31(8):2734-45
references: 21414896
references: Nature. 2001 Mar 22;410(6827):466-70
references: 11260713
references: J Exp Biol. 2005 Sep;208(Pt 18):3463-73
references: 16155219
references: Insect Mol Biol. 2010 Feb;19 Suppl 1:121-36
references: 20167023
references: J Chem Ecol. 2005 Nov;31(11):2731-45
references: 16273438
references: J Neurophysiol. 1991 Jul;66(1):131-9
references: 1919663
references: Learn Mem. 2005 Nov-Dec;12(6):636-45
references: 16287720
references: J Chem Ecol. 2003 Feb;29(2):321-36
references: 12737261
references: J Chem Ecol. 2003 Oct;29(10):2347-57
references: 14682516
references: Eur J Neurosci. 1998 Sep;10(9):2964-74
references: 9758166
references: Cell Tissue Res. 1990 Oct;262(1):9-34
references: 2124174
references: Cell Tissue Res. 2011 Feb;343(2):343-55
references: 21170552
references: Curr Opin Neurobiol. 2012 Apr;22(2):236-42
references: 22424844
references: J Neurosci. 2012 Apr 25;32(17):5772-82
references: 22539839
references: J Neurophysiol. 2012 Aug;108(4):1106-21
references: 22572948
references: Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11076-81
references: 12960372
references: Neuron. 2008 May 8;58(3):401-13
references: 18466750
references: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2008 May;194(5):501-15
references: 18389256
references: Chem Senses. 2011 Jul;36(6):497-8
references: 21441366
references: Cell. 2009 Oct 2;139(1):45-59
references: 19804753
references: Cell Tissue Res. 1999 Mar;295(3):383-94
references: 10022959