title: [The effect of catheter based renal synthetic denervation on renin-angiotensin-aldosterone system in patients with resistant hypertension].
abstract: OBJECTIVE
  to explore the effect of catheter based renal synthetic denervation on renin-angiotensin-aldosterone system (RAAS) and blood pressure reduction in patients with resistant hypertension. and assess the validity and security of the treatment.
  
  
  METHODS
  Ten patients with resistant hypertension from June 2011 to December 2011 were retrospectively reviewed, and then all of 10 patients screened for eligibility were allocated to renal denervation. Primary endpoints were changes of office blood pressure at 1 week, 1, 3 and 6 months after procedure. We assessed the effectiveness of renal sympathetic denervation with heart rate (HR), renin activity (PRA), angiotensin II (AngII), aldosterone (Ald), and creatinine (Cr) before and 2 weeks after procedure.
  
  
  RESULTS
  Office blood pressure after catheter-based renal denervation decreased by 22.8/9.1 mm Hg (1 mm Hg = 0.133 kPa), 34.8/14.7 mm Hg, 42.6/20.7 mm Hg, 43.2/21.6 mm Hg, at 1 week, 1, 3 and 6 months, respectively (P < 0.001). Meanwhile, the level of PRA, AngII, Ald decreased by (1.11 ± 0.89) ng×ml(-1)×h(-1) (P = 0.003), (17.06 ± 13.82) ng/L (P = 0.004), (404.5 ± 285.8) ng/L (P = 0.002), respectively; and heart rate decreased by 5.1 bpm (P = 0.002). However, the Cr level and eGFR did not change significantly (P > 0.05).
  
  
  CONCLUSIONS
  Catheter-based renal sympathetic denervation can reduce the level of renin activity, angiotensin II and aldosterone, and causes substantial and sustained blood-pressure reduction.
authors: Department of Cardiology of Tianjin First Center Hospital, Tianjin, China.
authors: Li
authors: L
authors: Wang
authors: Cheng-zhi
authors: CZ
authors: Lu
authors: Xin
authors: X
authors: Zhang
authors: Di
authors: D
authors: Luo
authors: Bin
authors: B
authors: Zhao
authors: Xiang
authors: X
authors: Yu
authors: Da-sheng
authors: DS
authors: Xia
authors: Xin
authors: X
authors: Chen
authors: Xiang-dong
authors: XD
authors: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D007668:Kidney / Q000294:innervation / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012084:Renin-Angiotensin System; D013562:Sympathectomy / Q000379:methods*