title: The role of automaticity and attention in neural processes underlying empathy for happiness, sadness, and anxiety.
abstract: Although many studies have examined the neural basis of empathy, relatively little is known about how empathic processes are affected by different attentional conditions. Thus, we examined whether instructions to empathize might amplify responses in empathy-related regions and whether cognitive load would diminish the involvement of these regions. Thirty-two participants completed a functional magnetic resonance imaging session assessing empathic responses to individuals experiencing happy, sad, and anxious events. Stimuli were presented under three conditions: watching naturally, actively empathizing, and under cognitive load. Across analyses, we found evidence for a core set of neural regions that support empathic processes (dorsomedial prefrontal cortex, DMPFC; medial prefrontal cortex, MPFC; temporoparietal junction, TPJ; amygdala; ventral anterior insula, AI; and septal area, SA). Two key regions-the ventral AI and SA-were consistently active across all attentional conditions, suggesting that they are automatically engaged during empathy. In addition, watching vs. empathizing with targets was not markedly different and instead led to similar subjective and neural responses to others' emotional experiences. In contrast, cognitive load reduced the subjective experience of empathy and diminished neural responses in several regions related to empathy and social cognition (DMPFC, MPFC, TPJ, and amygdala). The results reveal how attention impacts empathic processes and provides insight into how empathy may unfold in everyday interactions.
authors: Department of Psychology, Stanford University Stanford, CA, USA.
authors: Sylvia A
authors: SA
authors: Morelli
authors: Matthew D
authors: MD
authors: Lieberman
keywords: anxiety; attention; automaticity; cognitive load; empathy; fMRI; happiness; sadness
references: Nat Rev Neurosci. 2006 Apr;7(4):268-77
references: 16552413
references: Neuroscience. 2006 Apr 28;139(1):317-25
references: 16324799
references: Soc Cogn Affect Neurosci. 2009 Dec;4(4):423-8
references: 20035017
references: Neuroimage. 2003 Aug;19(4):1835-42
references: 12948738
references: Neuroimage. 2005 Feb 1;24(3):771-9
references: 15652312
references: Neuron. 2006 May 18;50(4):531-4
references: 16701204
references: Hum Brain Mapp. 2009 Mar;30(3):829-58
references: 18381770
references: Neuroimage. 2012 Jul 16;61(4):786-97
references: 22542636
references: Neuroimage. 2011 Jan 15;54(2):1735-42
references: 20728544
references: Behav Brain Res. 2002 Apr 1;131(1-2):17-36
references: 11844569
references: Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11382-7
references: 19549849
references: Ann N Y Acad Sci. 2010 Mar;1191:42-61
references: 20392275
references: Trends Cogn Sci. 2009 Aug;13(8):334-40
references: 19643659
references: Soc Cogn Affect Neurosci. 2009 Jun;4(2):127-33
references: 19151376
references: Neuropsychologia. 2007 Jun 11;45(10):2294-306
references: 17403530
references: Cogn Affect Behav Neurosci. 2004 Jun;4(2):270-8
references: 15460933
references: Neurology. 2003 Jan 28;60(2):266-71
references: 12552042
references: Behav Brain Sci. 2012 Jun;35(3):121-43
references: 22617651
references: Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20084-9
references: 18056800
references: Neuropsychologia. 2012 Jan;50(2):219-31
references: 22154962
references: Neuroscientist. 2007 Dec;13(6):580-93
references: 17911216
references: Neuron. 2006 May 18;50(4):655-63
references: 16701214
references: Eur J Neurosci. 2006 Mar;23(6):1658-64
references: 16553630
references: Psychol Bull. 2006 Jan;132(1):73-97
references: 16435958
references: J Cogn Neurosci. 2007 Jan;19(1):42-58
references: 17214562
references: Neuroimage. 2002 Jan;15(1):273-89
references: 11771995
references: Soc Cogn Affect Neurosci. 2014 Jan;9(1):39-47
references: 22887480
references: Psychol Sci. 2008 Jul;19(7):642-4
references: 18727776
references: Science. 2004 Feb 20;303(5661):1157-62
references: 14976305
references: Soc Cogn Affect Neurosci. 2013 Apr;8(4):446-54
references: 22355182
references: Neuroimage. 2003 Jul;19(3):1233-9
references: 12880848
references: J Cogn Neurosci. 2007 Jun;19(6):935-44
references: 17536964
references: Behav Brain Sci. 2002 Feb;25(1):1-20; discussion 20-71
references: 12625087
references: Neuropsychologia. 2008 Jan 15;46(1):160-73
references: 17825852
references: J Neurosci. 2009 Jul 1;29(26):8525-9
references: 19571143
references: Nat Rev Neurosci. 2009 Jan;10(1):59-70
references: 19096369
references: Neuroimage. 2011 Mar 1;55(1):381-8
references: 21122817
references: Eur J Neurosci. 2003 Dec;18(11):3134-44
references: 14656310
references: Neuroimage. 2007 May 15;36(1):256-67
references: 17400480
references: Neuroimage. 2006 May 15;31(1):440-57
references: 16466680
references: J Cogn Neurosci. 2009 Mar;21(3):489-510
references: 18510452
references: J Neurosci. 2009 Jan 28;29(4):1175-90
references: 19176826
references: Neuroimage. 2005 Mar;25(1):312-9
references: 15734365
references: Neuroimage. 2011 Feb 1;54(3):2492-502
references: 20946964
references: Psychosom Med. 2012 Jan;74(1):3-7
references: 22071630
references: Neuroreport. 2001 Aug 8;12(11):2433-8
references: 11496124
references: J Cogn Neurosci. 2012 Jan;24(1):235-45
references: 21878057
references: Neuropsychologia. 2010 Jul;48(9):2658-64
references: 20470808
references: Neuroimage. 2005 Apr 15;25(3):653-60
references: 15808966
references: Neuroimage. 2004 Mar;21(3):868-75
references: 15006653
references: Neurosci Biobehav Rev. 2011 Jan;35(3):903-11
references: 20974173
references: Brain. 2006 Nov;129(Pt 11):2945-56
references: 17008334
references: Neurosci Biobehav Rev. 2009 Sep;33(8):1198-203
references: 19538989
references: Soc Neurosci. 2008;3(2):97-112
references: 18633852
references: Behav Cogn Neurosci Rev. 2005 Jun;4(2):119-35
references: 16251728
references: J Neurosci. 2010 Oct 13;30(41):13906-15
references: 20943931
references: J Cogn Neurosci. 2003 Apr 1;15(3):324-37
references: 12729486
references: Nat Neurosci. 2012 Apr 15;15(5):669-74
references: 22504347
references: Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):523-8
references: 11756669
references: Soc Neurosci. 2007;2(3-4):276-91
references: 18633819