title: The role of miR-155 in regulatory T cells and rheumatoid arthritis.
abstract: Recently, various micro(mi)RNAs have been found deregulated in the setting of rheumatoid arthritis (RA), but their role in the pathogenesis of this disease remains a matter of debate. In the meanwhile, increasing evidence indicates a defective function of regulatory T cells (Tregs) in RA. This review discusses relevant studies addressing the function of Tregs and Cytotoxic T-Lymphocyte Antigen 4 in RA, provides recent data on the role of miRNAs for Tregs homeostasis, and focuses on the role of miR-155 in Tregs. In a final perspective section we discuss the potential impact of therapeutic miR-155 modulation in RA.
authors: Inserm U844, CHU Saint Eloi, INM, 80 rue Augustin Fliche, 34295 Montpellier cedex 5, France. dspoerl@postmail.ch
authors: D
authors: D
authors: Spoerl
authors: I
authors: I
authors: Duroux-Richard
authors: P
authors: P
authors: Louis-Plence
authors: C
authors: C
authors: Jorgensen
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology*; D060908:CTLA-4 Antigen / Q000276:immunology*; D006801:Humans; D035683:MicroRNAs / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D060908:CTLA-4 Antigen; C524942:MIRN155 microRNA, human; D035683:MicroRNAs