title: Schwannoma in neurofibromatosis type 1: a pitfall for detecting malignancy by metabolic imaging.
abstract: Neurofibromatosis type 1 (NF1) is a neurocutaneous syndrome characterized by the development of multiple peripheral nerve sheath tumors, the majority of which are benign neurofibromas. However, malignant peripheral nerve sheath tumors (MPNSTs) occur with a 10 % lifetime risk in patients with NF1, often developing within a neurofibroma. When clinical suspicion for an MPNST arises, imaging with FDG PET and MRI is performed to characterize a peripheral tumor for potential malignancy. In this report, we describe a patient with NF-1 who had two peripheral tumors with similar features by PET, both suspicious for MPNST, but differing features by MRI, one of which was subsequently determined to be an MPNST and the second to be a schwannoma.
authors: The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 North Wolfe Street, Baltimore, MD 21287, USA. sahlawa1@jhmi.edu
authors: Shivani
authors: S
authors: Ahlawat
authors: Jaishri
authors: J
authors: Blakeley
authors: Elizabeth
authors: E
authors: Montgomery
authors: Rathan M
authors: RM
authors: Subramaniam
authors: Allan
authors: A
authors: Belzberg
authors: Laura M
authors: LM
authors: Fayad
mesh_terms: D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control*; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000378:metabolism; D009456:Neurofibromatosis 1 / Q000175:diagnosis* / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
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