title: Serum magnesium levels in patients with diabetic retinopathy.
abstract: BACKGROUND
  Diabetic retinopathy is one of the leading causes of blindness in the world. Hypomagnesemia has been reported to occur at an increased frequency among patients with type 2 diabetes compared with their counterparts without diabetes. Hypomagnesemia has been linked to poor glycemic control. Many studies have been undergone to find out the precipitated factors of retinopathy such as duration and type of diabetes, hyperglycemia, hypomagnesemia and increased urinary total protein levels.
  
  
  OBJECTIVE
  This study was carried out to study the correlation between serum magnesium levels, glycosylated hemoglobin and urinary total protein levels in diabetic patients with retinopathy.
  
  
  METHODS
  The study population comprised of 30 type 2 diabetic patients without retinopathy as Group 2, 30 type 2 diabetic patients with retinopathy as Group 3 in the age group 45-75 years as cases and 60 age and sex matched healthy individuals as controls (Group 1). Determination of Serum Magnesium (photometric xylidyl blue method), glycosylated hemoglobin, Hb1C (IFCC), fasting blood glucose, postprandial blood glucose (glucose oxidase method) and urine total protein (Pyrogallol red method) was carried out. The statistical software SPSS 11.0 and Systat 8.0 were used for the analysis of the data.
  
  
  RESULTS
  Hypomagnesemia was observed in cases compared with both Group 2 and Group 3. FBS, PPBS, HbA1c, Urine total protein levels were increased in cases (without retinopathy and with retinopathy) compared with controls.
  
  
  CONCLUSIONS
  Hypomagnesemia and albuminuria individually or in conjunction serve as indicators for dysglycemia and could be used as marker for the risk of development of diabetic retinopathy.
authors: Department of Biochemistry, Medical College, Kolkata, West Bengal, India.
authors: Dipankar
authors: D
authors: Kundu
authors: Manish
authors: M
authors: Osta
authors: Tridibeswar
authors: T
authors: Mandal
authors: Ujjwal
authors: U
authors: Bandyopadhyay
authors: Debes
authors: D
authors: Ray
authors: Divyendu
authors: D
authors: Gautam
keywords: Diabetic retinopathy; glycosylated hemoglobin; magnesium; urinary protein
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