title: Development of nanofibrous cellulose acetate/gelatin skin substitutes for variety wound treatment applications.
abstract: The major component of fibrous extracellular matrix of dermis is composed of a complex combination of proteins and polysaccharides. Electrospun cellulose acetate/gelatin might be an effective simulator of the structure and composition of native skin and during this study, we electrospun cellulose acetate/gelatin membranes in various compositions and their performance as a scaffold for either skin tissue engineering or as a wound dressing was evaluated. Skin treatment products, whether tissue-engineered scaffolds or wound dressings, should be sufficiently hydrophilic to allow for gas and fluid exchange and absorb excess exudates while controlling the fluid loss. However, a wound dressing should be easily removable without causing tissue damage and a tissue-engineered scaffold should be able to adhere to the wound, and support cell proliferation during skin regeneration. We showed that these distinct adherency features are feasible just by changing the composition of cellulose acetate and gelatin in composite cellulose acetate/gelatin scaffolds. High proliferation of human dermal fibroblasts on electrospun cellulose acetate/gelatin 25:75 confirmed the capability of cellulose acetate/gelatin 25:75 nanofibers as a tissue-engineered scaffold, while the electrospun cellulose acetate/gelatin 75:25 can be a potential low-adherent wound dressing.
authors: 1Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran.
authors: Elham
authors: E
authors: Vatankhah
authors: Molamma P
authors: MP
authors: Prabhakaran
authors: Guorui
authors: G
authors: Jin
authors: Laleh Ghasemi
authors: LG
authors: Mobarakeh
authors: Seeram
authors: S
authors: Ramakrishna
mesh_terms: D049109:Cell Proliferation; D002478:Cells, Cultured; D002482:Cellulose / Q000031:analogs & derivatives*; D003094:Collagen / Q000378:metabolism; D005780:Gelatin; D006801:Humans; D057139:Nanofibers; D017768:Skin, Artificial; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering; D017155:Wettability; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: C005062:acetylcellulose; D005780:Gelatin; D002482:Cellulose; D003094:Collagen
keywords: Adherency; electrospun scaffold; gelatin; skin substitute; wound dressing