title: Nebulized salbutamol for asthma: effects on serum potassium and phosphate levels at the 60 min.
abstract: OBJECTIVE
  We conducted this prospective study to expand available information in relation to serum phosphate levels in treatment of acute asthma. A β-adrenergic agonist, salbutamol, was used for this purpose.
  
  
  METHODS
  Twenty-six patients who met the inclusion criteria as; age over 16 years, asthma history, and an acute exacerbation were included. Serum blood urea nitrogen, creatinine, glucose were within normal limits in all the patients. None of the patients were on chronic theophylline therapy. Baseline serum phosphate and potassium levels were measured. Nebulized salbutamol (2.5mg) was used three times at every hour. After 60 min, serum phosphate and potassium levels were measured.
  
  
  RESULTS
  Serum phosphate levels decreased from 3.7±0.9 mg/dL (baseline) to 3.6±0.9 mg/dL at 60 min. This decrease was not statistically significant (p=0.373). Serum potassium levels decreased significantly (p<0.001) from 4.6±0.7 mmol/L (baseline) to 4.3±0.7 mmol/L (60 min).
  
  
  CONCLUSIONS
  Administration of nebulized salbutamol during the emergency treatment of acute exacerbation of asthma is not associated with a statistical decrease in serum phosphate. There was significant hypokalemia. This study indicates that a further study is needed to elucidate the clinical significance of nebulized salbutamol on serum phosphate.
authors: Department of Emergency Medicine, Elazig Training & Education Hospital, Elazig, Turkey.
authors: M
authors: M
authors: Sahan
authors: M
authors: M
authors: Yılmaz
authors: Y
authors: Y
authors: Gokel
authors: E S
authors: ES
authors: Erden
authors: A
authors: A
authors: Karakus
mesh_terms: D000328:Adult; D000368:Aged; D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000097:blood* / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D010710:Phosphates / Q000097:blood*; D011188:Potassium / Q000097:blood*; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D001993:Bronchodilator Agents; D010710:Phosphates; D000420:Albuterol; D011188:Potassium
keywords: Asma; Asthma; Fosfato; Phosphate; Salbutamol