title: [Oxidised dextrans influence on reactive oxygen species generation by murine peritoneal exudate phagocytic cells].
abstract: The effects of oxidized dextrans of different molecular weight on reactive oxygen species production and transmembrane mitochondrial potential of macrophages and neutrophils have been studied in vivo and in vitro. Oxidised dextrans demonstrated moderate direct antioxidant ability but induced intracellular oxidative stress through the increase of oxygen radical generation. This effect of the investigated compounds amplifies the cytotoxic and bactericidal potential of phagocytes and can influence isoniazid metabolism, thus increasing its efficiency in therapy of infectious diseases.
authors: V O
authors: VO
authors: Tkachev
authors: M V
authors: MV
authors: Zaĭkovskaia
authors: A V
authors: AV
authors: Troitskiĭ
authors: N G
authors: NG
authors: Luzgina
authors: V A
authors: VA
authors: Shkurupiĭ
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000819:agonists / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy / Q000378:metabolism; D003911:Dextrans / Q000819:agonists / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D007538:Isoniazid / Q000819:agonists / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000473:pathology*; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D051379:Mice; D008970:Molecular Weight; D009504:Neutrophils / Q000166:cytology / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D010952:Plasma Substitutes / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D000995:Antitubercular Agents; D003911:Dextrans; D010952:Plasma Substitutes; D017382:Reactive Oxygen Species; D007538:Isoniazid