title: A noncanonical NF-κB pathway through the p50 subunit regulates Bcl-2 overexpression during an oxidative-conditioning hormesis response.
abstract: Cells can respond to damage and stress by activating various repair and survival pathways. One of these responses can be induced by preconditioning the cells with sublethal stress to provoke a prosurvival response that will prevent damage and death, and which is known as hormesis. Bcl-2, an antiapoptotic protein recognized by its antioxidant and prosurvival functions, has been documented to play an important role during oxidative-conditioning hormesis. Using an oxidative-hormetic model, which was previously established in the L929 cell line by subjecting the cells to a mild oxidative stress of 50 μM H₂O₂ for 9 h, we identified two different transductional mechanisms that participate in the regulation of Bcl-2 expression during the hormetic response. These mechanisms converge in activating the nuclear transcription factor NF-κB. Interestingly, the noncanonical p50 subunit of the NF-κB family is apparently the subunit that participates during the oxidative-hormetic response.
authors: Instituto Nacional de Geriatría, SSA, México, DF 10200, México.
authors: Armando
authors: A
authors: Luna-López
authors: Viridiana Y
authors: VY
authors: González-Puertos
authors: Jacqueline
authors: J
authors: Romero-Ontiveros
authors: José L
authors: JL
authors: Ventura-Gallegos
authors: Alejandro
authors: A
authors: Zentella
authors: Luis E
authors: LE
authors: Gomez-Quiroz
authors: Mina
authors: M
authors: Königsberg
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D059165:Hormesis; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D051379:Mice; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D052002:NF-kappa B p50 Subunit / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D019253:Proto-Oncogene Proteins c-bcl-2; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D016328:NF-kappa B; D052002:NF-kappa B p50 Subunit; D019253:Proto-Oncogene Proteins c-bcl-2; D006861:Hydrogen Peroxide
keywords: Adaptive response; Akt; Bcl-2; Free radicals; Hormesis; Hydrogen peroxide; NF-κB; Oxidative stress; PI3K; PKC