title: Role of p21-activated kinases in cardiovascular development and function.
abstract: p21-activated kinases (Paks) are a group of six serine/threonine kinases (Pak1-6) that are involved in a variety of biological processes. Recently, Paks, more specifically Pak1, -2, and -4, have been shown to play important roles in cardiovascular development and function in a range of model organisms including zebrafish and mice. These functions include proper morphogenesis and conductance of the heart, cardiac contractility, and development and integrity of the vasculature. The mechanisms underlying these effects are not fully known, but they likely differ among the various Pak isoforms and include both kinase-dependent and -independent functions. In this review, we discuss aspects of Pak function relevant to cardiovascular biology as well as potential therapeutic implications of small-molecule Pak inhibitors in cardiovascular disease.
authors: Department of Biochemistry, Drexel University School of Medicine, Philadelphia, PA, USA.
authors: Mollie L
authors: ML
authors: Kelly
authors: Artyom
authors: A
authors: Astsaturov
authors: Jonathan
authors: J
authors: Chernoff
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D020033:Protein Isoforms / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000627:therapeutic use; D015398:Signal Transduction; D054462:p21-Activated Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D020033:Protein Isoforms; D047428:Protein Kinase Inhibitors; D054462:p21-Activated Kinases
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