title: RB goes mitochondrial.
abstract: The retinoblastoma tumor suppressor RB is well known for its capacity to restrict cell cycle progression at the G1/S transition of the cell cycle by controlling the transcription of cell cycle genes. In this issue of Genes & Development, Hilgendorf and colleagues (pp. 1003-1015) have identified a novel tumor suppressor function for RB independent of its role as a transcriptional regulator, in which RB directly activates the apoptosis regulator Bax at the mitochondria to promote cell death.
authors: Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA.
authors: Laura D
authors: LD
authors: Attardi
authors: Julien
authors: J
authors: Sage
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D016160:Retinoblastoma Protein / Q000378:metabolism*
chemical_list: D016160:Retinoblastoma Protein
keywords: MOMP; apoptosis; cancer; pRB; retinoblastoma protein
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