title: Anti-HIV and NO production inhibition activities of epi-aleuritolic acid derivatives.
abstract: Fifteen epi-aleuritolic acid derivatives were synthesized and evaluated for anti-HIV activity in 293 T cells and NO production inhibition activity. Of the derivatives, 1, 2, 3, 4, 11, and 13 showed relatively potent anti-HIV activity with EC50 values ranging from 5.80 to 13.30 μM. The most potent compound, 3α-2',2'-dimethylsuccinic acyl epi-aleuritolic acid (11), displayed significant anti-HIV activity with an EC50 value of 5.80 μM. Compounds 1, 3, 4, and 11 showed NO inhibition activity, with IC50 values ranging from 3.40 to 7.10 μM and compound 1 inhibited NO production with an IC50 value of 3.40 μM.
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors: Jia-Bao
authors: JB
authors: Liu
authors: Ying
authors: Y
authors: Zhang
authors: Bao-Song
authors: BS
authors: Cui
authors: Ying-Li
authors: YL
authors: Cao
authors: Shao-Peng
authors: SP
authors: Yuan
authors: Ying
authors: Y
authors: Guo
authors: Qi
authors: Q
authors: Hou
authors: Shuai
authors: S
authors: Li
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D010169:Palmitic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C582537:3alpha-2',2'-dimethylsuccinyl-14-taraxeren-28-acid; D019380:Anti-HIV Agents; D010169:Palmitic Acids; D009569:Nitric Oxide; C059860:aleuritolic acid