title: Comparison study of the partial-breast irradiation techniques: dosimetric analysis of three-dimensional conformal radiation therapy, electron beam therapy, and helical tomotherapy depending on various tumor locations.
abstract: The partial-breast irradiation (PBI) technique, an alternative to whole-breast irradiation, is a beam delivery method that uses a limited range of treatment volume. The present study was designed to determine the optimal PBI treatment modalities for 8 different tumor locations. Treatment planning was performed on computed tomography (CT) data sets of 6 patients who had received lumpectomy treatments. Tumor locations were classified into 8 subsections according to breast quadrant and depth. Three-dimensional conformal radiation therapy (3D-CRT), electron beam therapy (ET), and helical tomotherapy (H-TOMO) were utilized to evaluate the dosimetric effect for each tumor location. Conformation number (CN), radical dose homogeneity index (rDHI), and dose delivered to healthy tissue were estimated. The Kruskal-Wallis, Mann-Whitney U, and Bonferroni tests were used for statistical analysis. The ET approach showed good sparing effects and acceptable target coverage for the lower inner quadrant-superficial (LIQ-S) and lower inner quadrant-deep (LIQ-D) locations. The H-TOMO method was the least effective technique as no evaluation index achieved superiority for all tumor locations except CN. The ET method is advisable for treating LIQ-S and LIQ-D tumors, as opposed to 3D-CRT or H-TOMO, because of acceptable target coverage and much lower dose applied to surrounding tissue.
authors: Department of Biomedical Engineering, The Catholic University of Korea, Seoul, Republic of Korea.
authors: Min-Joo
authors: MJ
authors: Kim
authors: So-Hyun
authors: SH
authors: Park
authors: Seok-Hyun
authors: SH
authors: Son
authors: Keum-Seong
authors: KS
authors: Cheon
authors: Byung-Ock
authors: BO
authors: Choi
authors: Tae-Suk
authors: TS
authors: Suh
mesh_terms: D001940:Breast / Q000528:radiation effects*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D004583:Electrons / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000379:methods*; D036542:Tomography, Spiral Computed / Q000379:methods*
keywords: 3D conformal radiation therapy; Electron beam therapy; Partial-breast irradiation; Tumor location