title: [The role of calmodulin in calcium-dependent signalling in excitable cells].
abstract: Calmodulin (CaM) is a sensor protein, which takes part in calcium-dependent signaling, regulating processes like growth, differentiation, proliferation and motility. Calmodulin binds calcium ions during induction of intracellular signaling. It is also involved in silencing of calcium signal through activation of plasma membrane Ca(2+)-ATPase (directly) or SERCA pump (indirectly). Calmodulin may affect various channels, e.g. voltage gated calcium channels (VGCCs), transient receptor potential channels (TRPCs), NMDA receptors, calcium channels dependent on cyclic nucleotides or these located in endoplasmic reticulum (ryanodine receptors and all isoforms of IP3-dependent receptors).
authors: Zakład Neurochemii Molekularnej, Katedra Biochemii Medycznej, Uniwersytet Medyczny w Łodzi, Łódź. elzbieta.rebas@umed.lodz.pl
authors: Elzbieta
authors: E
authors: Rebas
authors: Tomasz
authors: T
authors: Boczek
authors: Antoni
authors: A
authors: Kowalski
authors: Kinga
authors: K
authors: Kuśmirowska
authors: Malwina
authors: M
authors: Lisek
authors: Ludmiła
authors: L
authors: Zylińska
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D002147:Calmodulin / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000378:metabolism; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D002147:Calmodulin; D053496:Inositol 1,4,5-Trisphosphate Receptors; D019837:Ryanodine Receptor Calcium Release Channel; D050051:Transient Receptor Potential Channels