title: Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals.
abstract: We have developed an integrated microfluidic platform for producing 2-[(18)F]-fluoro-2-deoxy-D-glucose ((18)F-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40-80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals.
authors: National Nanotechnology Laboratory (NNL)-Institute of Nanoscience (NANO), CNR, Lecce, Italy. valentina.arima@nano.cnr.it
authors: Valentina
authors: V
authors: Arima
authors: Giancarlo
authors: G
authors: Pascali
authors: Oliver
authors: O
authors: Lade
authors: Hans R
authors: HR
authors: Kretschmer
authors: Ingo
authors: I
authors: Bernsdorf
authors: Victoria
authors: V
authors: Hammond
authors: Paul
authors: P
authors: Watts
authors: Francesco
authors: F
authors: De Leonardis
authors: Mark D
authors: MD
authors: Tarn
authors: Nicole
authors: N
authors: Pamme
authors: Benjamin Z
authors: BZ
authors: Cvetkovic
authors: Petra S
authors: PS
authors: Dittrich
authors: Nikola
authors: N
authors: Vasovic
authors: Russell
authors: R
authors: Duane
authors: Aleksandar
authors: A
authors: Jaksic
authors: Antonella
authors: A
authors: Zacheo
authors: Alessandra
authors: A
authors: Zizzari
authors: Lucia
authors: L
authors: Marra
authors: Elisabetta
authors: E
authors: Perrone
authors: Piero A
authors: PA
authors: Salvadori
authors: Rosaria
authors: R
authors: Rinaldi
mesh_terms: D004867:Equipment Design; D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D049268:Positron-Emission Tomography; D011312:Pressure; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D012972:Sodium Hydroxide / Q000737:chemistry; D013696:Temperature
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D012972:Sodium Hydroxide