title: Transcriptional regulation of endothelial cell and vascular development.
abstract: The establishment and maintenance of the vascular system is critical for embryonic development and postnatal life. Defects in endothelial cell development and vessel formation and function lead to embryonic lethality and are important in the pathogenesis of vascular diseases. Here, we review the underlying molecular mechanisms of endothelial cell differentiation, plasticity, and the development of the vasculature. This review focuses on the interplay among transcription factors and signaling molecules that specify the differentiation of vascular endothelial cells. We also discuss recent progress on reprogramming of somatic cells toward distinct endothelial cell lineages and its promise in regenerative vascular medicine.
authors: Department of Pharmacology, Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA.
authors: Changwon
authors: C
authors: Park
authors: Tae Min
authors: TM
authors: Kim
authors: Asrar B
authors: AB
authors: Malik
mesh_terms: D002319:Cardiovascular System / Q000196:embryology*; D002454:Cell Differentiation / Q000502:physiology; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology*; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D014157:Transcription Factors
keywords: angiogenesis; endothelial cells; reprogramming; transcription factors; vasculogenesis
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