title: Phenotypic features of the dynamics of HIF-1α levels in rat neocortex in different hypoxia regimens.
abstract: There are tissue-specific and phenotypic differences in the basal levels of HIF-1α under normoxic conditions. Induction of short-term adaptation to hypoxia and formation of long-term adaptation are genetically determined. These phenomena are observed only in animals with low resistance to hypoxia and are associated with biphasic expression of HIF-1α in the neocortex only during hypoxic preconditioning. Severe hypoxia disorders HIF-1α expression and impairs the formation of short-term and long-term resistance. In animals with high resistance to hypoxia, neither short-term nor long-term resistance develops in response to hypoxic exposure, and this correlates with the absence of changes in post-hypoxic HIF-1α levels in the neocortex.
authors: Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors: Yu I
authors: YI
authors: Kirova
authors: E L
authors: EL
authors: Germanova
authors: L D
authors: LD
authors: Lukyanova
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D021461:Animals, Outbred Strains; D015687:Cell Hypoxia; D005786:Gene Expression Regulation; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D008297:Male; D019579:Neocortex / Q000378:metabolism*; D009928:Organ Specificity; D010641:Phenotype; D051381:Rats
chemical_list: C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit