title: Relationship between serum TGF-β1, OPG levels and osteoporotic risk in native Chinese women.
abstract: BACKGROUND
  Cytokines including transforming growth factor beta 1 (TGF-β1) and osteoprotegerin (OPG) are closely related to bone metabolism. However, the relationships between TGF-β1, OPG and risk of osteoporosis in native Chinese women are unknown. Our research indicated that there is a positive correlation between TGF-β1 and bone mineral density (BMD) T-score, and a negative correlation between OPG and T-score. The risk of osteoporosis is reduced as TGF-β1 increases and increases as OPG was raised. We investigated correlations of BMD T-scores with circulating TGF-β1 and BMD T-scores with circulating OPG in healthy native Chinese women, and to study the effects of changes in TGF-β1 and OPG on osteoporosis.
  
  
  METHODS
  This was a cross-sectional study of 691 healthy native Chinese women aged 20-80 years. Concentrations of serum TGF-β1 and OPG were determined. BMD T-scores at the posteroanterior spine, left hip, and forearm were measured by dual-energy X-ray absorptiometry.
  
  
  RESULTS
  There were positive correlations between serum TGF-β1 and T-scores at the various skeletal sites (r=0.167-0.285, all P=0.000) and negative correlations between serum OPG and T-scores (r=-0.179 to -0.270, all P=0.007-0.000). After adjusting for age and BMI, correlations between TGF-β1 and T-score at the lumbar vertebrae and ultradistal forearm, and between OPG and T-score at the ultradistal forearm in premenopausal subjects, remained statistically significant. Multivariate linear stepwise analysis showed that TGF-β1 could explain 1.9-8.3% of T-score variation at each skeletal site. OPG could explain 2.4-4.4% of T-score variation. When TGF-β1 and OPG concentrations were grouped according to quartile intervals, T-score and the prevalence and risk of osteoporosis varied with changes in the cytokines.
  
  
  CONCLUSIONS
  The risk of osteoporosis in native Chinese women increased as circulating TGF-β1 was reduced and OPG was raised.
authors: Institute of Metabolism and Endocrinology, The Second XiangYa Hospital, of Central South University, 139# Middle Renmin Road, Changsha, Hunan 410011, PR China.
authors: Gen-Qing
authors: GQ
authors: Xie
authors: Dan-Dan
authors: DD
authors: Lei
authors: Hong-Bo
authors: HB
authors: He
authors: Jia-Ji
authors: JJ
authors: Gong
authors: Chao
authors: C
authors: Chen
authors: Peng
authors: P
authors: Chen
authors: Hong
authors: H
authors: Zhang
authors: Xiang-Hang
authors: XH
authors: Luo
authors: Er-Yuan
authors: EY
authors: Liao
authors: Xian-Ping
authors: XP
authors: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D002681:China; D005260:Female; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood*; D053244:Osteoprotegerin / Q000097:blood*; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000097:blood*; D055815:Young Adult
chemical_list: D053244:Osteoprotegerin; D053773:Transforming Growth Factor beta1