title: Effect of ultrasonic irradiation on the development of symptoms of depression and anxiety in rats.
abstract: Behavioral reactions of rats were studied under conditions of constant exposure to ultrasonic irradiation at a frequency of 20-45 kHz for 21 days. In rats subjected to ultrasound, impaired behavior in the social interest test and Porsolt forced swimming test was observed; the development of anhedonia in the sucrose preference test was revealed (manifested in the symptoms of depression). The effects of ultrasonic irradiation were abolished by an antidepressant fluoxetine, a selective serotonin reuptake inhibitor. Our results indicate that chronic exposure to ultrasonic radiation produces a modulatory effect on depressive symptoms in rats. These changes satisfy the requirements for experimental animals, which are used as a model of psychopathological processes.
authors: Department of Basic and Applied Neurobiology, V. P. Serbsky State Research Center for Social and Forensic Psychiatry, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia. hakurate77@gmail.com
authors: A Yu
authors: AY
authors: Morozova
authors: E A
authors: EA
authors: Zubkov
authors: Z I
authors: ZI
authors: Storozheva
authors: Z I
authors: ZI
authors: Kekelidze
authors: V P
authors: VP
authors: Chekhonin
mesh_terms: D059445:Anhedonia / Q000187:drug effects; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy / Q000209:etiology*; D001522:Behavior, Animal / Q000187:drug effects; D003863:Depression / Q000188:drug therapy / Q000209:etiology*; D004195:Disease Models, Animal; D005473:Fluoxetine / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity; D051381:Rats; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012919:Social Behavior; D013016:Sound / Q000009:adverse effects*; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors