title: Ras signal triggers β-amyloid precursor protein (APP) expression.
abstract: It has recently been discovered that the Drosophila β-amyloid protein precursor like (Appl) gene, the ortholog of the human β-Amyloid Precursor Protein (APP) gene, is transcriptionally activated by receptor tyrosine kinase activity that involves Ras/MAPK signaling in vivo. This regulation is specifically controlled in photoreceptor neurons of the Drosophila retina. This suggests that some cases of Alzheimer disease, those which have been associated with high expression of the APP gene, may involve Ras signal transduction.
authors: Departament de Genètica; Facultat de Biologia; Institut de Biomedicina de la Universitat de Barcelona (IBUB); Universitat de Barcelona; Barcelona, Spain; Laboratory of Neurogenetics; Department of Molecular and Developmental Genetics; VIB; Leuven, Belgium.
authors: Natalia
authors: N
authors: Mora
authors: Departament de Genètica; Facultat de Biologia; Institut de Biomedicina de la Universitat de Barcelona (IBUB); Universitat de Barcelona; Barcelona, Spain.
authors: Paula
authors: P
authors: Santa Bárbara Ruiz
authors: Departament de Genètica; Facultat de Biologia; Institut de Biomedicina de la Universitat de Barcelona (IBUB); Universitat de Barcelona; Barcelona, Spain.
authors: Nuno
authors: N
authors: Ferreira
authors: Departament de Genètica; Facultat de Biologia; Institut de Biomedicina de la Universitat de Barcelona (IBUB); Universitat de Barcelona; Barcelona, Spain.
authors: Florenci
authors: F
authors: Serras
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D004330:Drosophila / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D010786:Photoreceptor Cells / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D012160:Retina / Q000378:metabolism; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism*
chemical_list: D016564:Amyloid beta-Protein Precursor; D020794:Receptor Protein-Tyrosine Kinases; D020929:Mitogen-Activated Protein Kinase Kinases; D018631:ras Proteins
keywords: Drosophila; Ras; development; photoreceptor; ß-amyloid
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