title: Antioxidant properties and UV absorbance pattern of mycosporine-like amino acids analogs synthesized in an environmentally friendly manner.
abstract: In current study, we report efficient and clean procedure for preparing mycosporine-like amino acids (MMAs) analogs and evaluate their ultraviolet absorbance properties and antioxidant activities. The ultraviolet radiation absorbance patterns of the compounds were recorded and then used to define their molar absorptivities. The antioxidant activities were assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and superoxide radical scavenging assays. Eight of nine compounds showed good activity against superoxide radicals, as only one of the analogs exhibited a measurable IC50 in the DPPH assay.
authors: Department of Clinical Chemistry, Faculty of Pharmaceutical Sciences, University of São Paulo, 05508-900, São Paulo-SP, Brazil. andreguetti@usp.br
authors: Daniel
authors: D
authors: Andreguetti
authors: Erika M
authors: EM
authors: Stein
authors: Claudio M P
authors: CM
authors: Pereira
authors: Ernani
authors: E
authors: Pinto
authors: Pio
authors: P
authors: Colepicolo
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology*; D001713:Biphenyl Compounds; D003510:Cyclohexanes / Q000138:chemical synthesis / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000493:pharmacokinetics; D055772:Green Chemistry Technology / Q000379:methods; D015394:Molecular Structure; D010851:Picrates; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D014466:Ultraviolet Rays
chemical_list: D000596:Amino Acids; D000975:Antioxidants; D001713:Biphenyl Compounds; D003510:Cyclohexanes; D016166:Free Radical Scavengers; D010851:Picrates; D011837:Radiation-Protective Agents; C004931:1,1-diphenyl-2-picrylhydrazyl