title: Acute toxicity of TiO2 nanoparticles to Ceriodaphnia dubia under visible light and dark conditions in a freshwater system.
abstract: The ever increasing industrial and consumer applications of titanium dioxide nanoparticles (TiO2 NPs) raise concern over the possible risk associated with their environmental exposure. Still, the knowledge regarding nanoparticle behavior in a freshwater ecosystem is lacking. The current study focuses on the toxicity of TiO2 NPs towards Ceriodaphnia dubia (a dominant daphnid isolated from the freshwater) under two different conditions; (1) light and dark photoperiod (16:8 h) and (2) continuous dark conditions, for a period of 48 h. An increase in toxicity was observed with an increase in the concentration, until a certain threshold level (under both photoperiod and dark conditions), and beyond which, reduction was noted. The decrease in toxicity would have resulted from the aggregation and settling of NPs, making them less bioavailable. The oxidative stress was one of the major contributors towards cytotoxicity under both photoperiod and dark conditions. The slow depuration of TiO2 NPs under the photoperiod conditions confirmed a higher NP bioaccumulation and thus a higher bioconcentration factor (BCF) compared to dark conditions. The transmission electron micrographs confirmed the bioaccumulation of NPs and damage of tissues in the gut lining.
authors: Centre for Nanobiotechnology, VIT University, Vellore, Tamil Nadu, India.
authors: Swayamprava
authors: S
authors: Dalai
authors: Sunandan
authors: S
authors: Pakrashi
authors: Natarajan
authors: N
authors: Chandrasekaran
authors: Amitava
authors: A
authors: Mukherjee
mesh_terms: D000818:Animals; D033361:Cladocera / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D005618:Fresh Water; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D008027:Light; D053768:Metal Nanoparticles / Q000633:toxicity*; D018384:Oxidative Stress; D017440:Photoperiod; D014025:Titanium / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical; C009495:titanium dioxide; D014025:Titanium
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