title: Blood pressure changes associated with periodic leg movements during sleep in healthy subjects.
abstract: OBJECTIVE
  Periodic leg movements during sleep (PLMS) are associated with important blood pressure (BP) increases in restless legs syndrome (RLS) patients. These movements also are highly prevalent in the healthy elderly population. The aims of our study were to evaluate if heart rate (HR) and BP changes associated with PLMS are present in healthy subjects with no report of health concerns and to compare the amplitude of cardiovascular changes in healthy subjects to that of RLS subjects.
  
  
  METHODS
  Fourteen healthy subjects (six men, eight women; 46.6±9.7 y) and 14 RLS subjects (six men, eight women; 47.6±11.8 y) matched for age and gender participated in our study. Beat-to-beat noninvasive BP was continuously recorded during one night of polysomnography. HR, systolic BP (SBP) and diastolic BP (DBP) were measured for 10 beats before and 15 beats after onset of PLMS with and without microarousals (MA).
  
  
  RESULTS
  PLMS were associated with sudden and significant increases of HR, SBP and DBP in both groups; however, cardiovascular increases were more pronounced in RLS subjects than in healthy subjects.
  
  
  CONCLUSIONS
  Because PLMS index increases with age in healthy subjects and aging is associated with higher cardiovascular risk, further studies should investigate the impact of PLMS-related BP changes on the development of cardiovascular diseases in healthy elderly populations.
authors: Center for Advanced Research in Sleep Medicine, Sacre-Cœur Hospital, University of Montreal, Canada.
authors: Marie-Hélène
authors: MH
authors: Pennestri
authors: Jacques
authors: J
authors: Montplaisir
authors: Lorraine
authors: L
authors: Fradette
authors: Gilles
authors: G
authors: Lavigne
authors: Roberto
authors: R
authors: Colombo
authors: Paola A
authors: PA
authors: Lanfranchi
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D064368:Healthy Volunteers; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D017286:Polysomnography; D015995:Prevalence; D012148:Restless Legs Syndrome / Q000453:epidemiology / Q000503:physiopathology*; D012307:Risk Factors; D013564:Sympathetic Nervous System / Q000502:physiology