title: Prospective head and neck cancer research: a four-decade bibliometric perspective.
abstract: BACKGROUND
  It is unknown whether changes in study sponsorship have affected the proportion of prospective research on surgery, radiotherapy, and pharmacotherapy for head and neck squamous cell carcinoma (HNSCC) being published over time.
  
  
  METHODS
  We examined prospective studies from PubMed, Ovid MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials from 1980, 1985, 1990, 1995, 2000, 2005, and 2010. Chi-squared tests were used to identify significant associations between sponsorship and authorship, treatments within study protocols, and presentation of results, whereas time-based trends were analyzed using the Cochran-Armitage test.
  
  
  RESULTS
  Among 309 articles, industry (70, 22.7%) and the U.S. government (65, 21%) were the most common sponsors. There was a significant increase in the proportion of industry-sponsored research (p for trend = .013) and a decline in U.S. government-sponsored research (p for trend = .001) over time. The inclusion of surgery in treatment protocols declined over the past four decades (p for trend = .003). Protocols incorporating pharmacotherapy were more likely to have industry support than those without pharmacotherapy (p = .001), whereas protocols with radiotherapy (p = .003) or surgery (p = .002) were less likely to have industry support.
  
  
  CONCLUSIONS
  Industry is the predominant sponsor of prospective HNSCC research, with an emphasis on pharmacotherapy.
authors: Robert Wood Johnson Foundation Clinical Scholars, University of Michigan, Ann Arbor, Michigan, USA. gordonsu@med.umich.edu
authors: Gordon H
authors: GH
authors: Sun
authors: Jeffrey J
authors: JJ
authors: Houlton
authors: Nicholas M
authors: NM
authors: Moloci
authors: Mark P
authors: MP
authors: MacEachern
authors: Carol R
authors: CR
authors: Bradford
authors: Mark E
authors: ME
authors: Prince
authors: Reshma
authors: R
authors: Jagsi
mesh_terms: D015706:Bibliometrics; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D016239:MEDLINE; D011446:Prospective Studies; D011642:Publications; D011643:Publishing; D012106:Research
keywords: Bibliometrics; Chemotherapy; Funding; Otolaryngology; Radiotherapy; Surgery
references: Ann Surg. 2002 Sep;236(3):277-86; discussion 286-7
references: 12192314
references: Mayo Clin Proc. 2008 Apr;83(4):489-501
references: 18380996
references: Curr Opin Otolaryngol Head Neck Surg. 2004 Apr;12(2):82-7
references: 15167042
references: Head Neck. 2008 Dec;30(12):1636-42
references: 18642286
references: JAMA. 2010 Jan 13;303(2):137-43
references: 20068207
references: JAMA. 2005 Sep 21;294(11):1333-42
references: 16174691
references: N Engl J Med. 2000 May 18;342(20):1539-44
references: 10816196
references: Cancer. 2007 Apr 1;109(7):1239-46
references: 17326054
references: Ann Surg. 2012 Mar;255(3):427-32
references: 22281701
references: Eur J Cancer. 2005 Oct;41(15):2237-40
references: 16214044
references: Laryngoscope. 2006 Sep;116(9 Pt 2 Suppl 111):1-13
references: 16946667
references: J Clin Oncol. 2010 Mar 10;28(8):1316-21
references: 20065190
references: J Clin Oncol. 2007 Jan 10;25(2):180-6
references: 17210937
references: Oncology (Williston Park). 2010 Sep;24(10):915-9, 924
references: 21138172
references: Arch Otolaryngol Head Neck Surg. 1997 May;123(5):475-83
references: 9158393
references: Int J Cancer. 2010 Dec 15;127(12):2893-917
references: 21351269
references: Eur J Cancer. 2010 Mar;46(5):912-9
references: 20064708
references: N Engl J Med. 2000 Feb 24;342(8):586-7
references: 10691499
references: Head Neck. 2013 Oct;35(10):1515-20
references: 22987508
references: Sci Eng Ethics. 2001 Apr;7(2):205-18
references: 11349360
references: Cancer. 2009 Jun 15;115(12):2783-91
references: 19434666
references: Eur J Cancer. 2006 Dec;42(18):3140-8
references: 17079135
references: N Engl J Med. 2006 Jul 20;355(3):281-7
references: 16855268
references: Clin Colorectal Cancer. 2011 Dec;10(4):290
references: 22122894
references: J Surg Oncol. 2007 Feb 1;95(2):161-6
references: 17262723
references: J Clin Oncol. 2008 Nov 20;26(33):5458-64
references: 18955452
references: Ann Surg. 2008 Feb;247(2):217-21
references: 18216525
references: World J Surg. 2005 May;29(5):606-9
references: 15827835
references: Lancet. 1996 Apr 13;347(9007):984-5
references: 8606606