title: Effectiveness of second corticosteroid injections for carpal tunnel syndrome.
abstract: BACKGROUND
  A single local corticosteroid injection is an effective treatment for carpal tunnel syndrome. No study has specifically examined the effectiveness of a second injection on relapse after primary injection.
  
  
  METHODS
  We identified a cohort of patients who had received an initial corticosteroid injection into 1 wrist and then, at a later date, a second injection into the same wrist. We compared the change in the Boston Symptom Severity Scale (SSS) and Functional Status Scale (FSS) between first and second injections.
  
  
  RESULTS
  In 229 patients who received 2 injections the mean improvement on the SSS was 1.2 (SD = 0.8) for the first injection and 1.3 (SD = 0.9) for the second, which was not statistically significant. Improvement in FSS for the first injection was 0.4 (SD = 0.8) and 0.7 (SD = 0.8) for the second, which was statistically significant (P < 0.001).
  
  
  CONCLUSIONS
  Second corticosteroid injections appear to be at least as effective as the first.
authors: Division Physical Medicine and Rehabilitation, University of Alberta, 10230 111 Avenue, Edmonton T5G 0B7, Canada. nigel.ashworth@albertahealthservices.ca
authors: Nigel L
authors: NL
authors: Ashworth
authors: Jeremy D P
authors: JD
authors: Bland
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D002349:Carpal Tunnel Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D015331:Cohort Studies; D016208:Databases, Factual; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones