title: Investigation of resolution effects using a specialized diffusion tensor phantom.
abstract: OBJECTIVE
  The clinical potential of the diffusion imaging-based analysis of fine brain structures such as fornix or cingulum is high due to the central role of these structures in psychiatric diseases. However, the quantification of diffusion parameters in fine structures is especially prone to partial volume effects (PVEs).
  
  
  METHODS
  In this study, a phantom for the investigation of PVEs and their influence on diffusion parameters in fine structures of different diameter is presented. The phantom is produced by winding wet polyester fibers onto a spindle. The resulting fiber strands have well defined square cross-sections of 1-25 mm(2) and provide a homogeneous and high fractional anisotropy (FA ≈ 0.9).
  
  
  RESULTS
  Several PVEs are demonstrated and analyzed. It is shown that inferred results such as the fiber geometry and diffusion parameters strongly depend on the relative position of the structure of interest to the voxel-grid. Several implications of PVEs on post-processing methods such as Tract-based Spatial Statistics and fiber tractography are demonstrated.
  
  
  CONCLUSIONS
  These results show that the handling of PVEs in common post-processing tasks can be problematic, and that the presented phantom provides a valuable tool for the improvement and evaluation of these effects.
authors: Quantitative Imaging-based Disease Characterization, German Cancer Research Center, Heidelberg, Germany; Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany.
authors: Michael
authors: M
authors: Bach
authors: Klaus H
authors: KH
authors: Fritzsche
authors: Bram
authors: B
authors: Stieltjes
authors: Frederik B
authors: FB
authors: Laun
mesh_terms: D000465:Algorithms; D001921:Brain / Q000166:cytology*; D056324:Diffusion Tensor Imaging / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity