title: Urinary tract infections: current and emerging management strategies.
abstract: Acute cystitis is one of the most commonly encountered bacterial infections and is responsible for substantial morbidity and high medical costs in the United States and across the globe. Though generally considered to be self-limiting and easily treated with antibiotics, urinary tract infections (UTIs) are often incompletely resolved by antibiotic therapy and frequently recur. This is in part due to the ability of uropathogenic bacteria to invade, replicate, and persist within host epithelial cells. The biological complexity of these infections combined with a dramatic rise in antibiotic-resistant pathogens highlight the need for alternative therapies. In this review we examine current management strategies for UTIs, as well as emerging treatments, including novel compounds that block bacterial interactions with the urothelium and vaccines focused on preventing both acute and recurrent infections.
authors: Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, 15 N Medical Dr E, #2100, Salt Lake City, UT 84112, USA.
authors: Amelia E
authors: AE
authors: Barber
authors: J Paul
authors: JP
authors: Norton
authors: Adam M
authors: AM
authors: Spivak
authors: Matthew A
authors: MA
authors: Mulvey
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D014481:United States; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents
keywords: UPEC; antibiotic resistance; cystitis; recurrent UTI; vaccine
references: Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1333-8
references: 14739341
references: Trends Microbiol. 2009 Oct;17(10):431-2
references: 19758805
references: EMBO J. 2000 Jun 15;19(12):2803-12
references: 10856226
references: J Infect Dis. 2000 Feb;181(2):774-8
references: 10669375
references: Antimicrob Agents Chemother. 2010 May;54(5):1855-63
references: 20231390
references: FEMS Microbiol Rev. 2012 Nov;36(6):1046-82
references: 22545799
references: Bioorg Med Chem. 2012 May 1;20(9):3128-42
references: 22464688
references: Clin Infect Dis. 2011 Mar 1;52(5):e103-20
references: 21292654
references: Can J Microbiol. 2006 Nov;52(11):1093-102
references: 17215901
references: J Med Chem. 2010 Dec 23;53(24):8627-41
references: 21105658
references: Am Fam Physician. 2011 Sep 1;84(5):519-26
references: 21888302
references: J Clin Invest. 1997 Sep 1;100(5):1123-36
references: 9276729
references: Eur J Clin Invest. 2008 Oct;38 Suppl 2:29-38
references: 18826479
references: J Med Chem. 2010 Jun 24;53(12):4779-92
references: 20507142
references: Exp Mol Pathol. 2008 Aug;85(1):11-9
references: 18482721
references: Traffic. 2005 Jan;6(1):18-31
references: 15569242
references: Dtsch Arztebl Int. 2010 May;107(21):361-7
references: 20539810
references: J Clin Microbiol. 2012 Oct;50(10):3202-7
references: 22814460
references: Pharmacoeconomics. 2005;23(11):1123-42
references: 16277548
references: Antimicrob Agents Chemother. 2012 Sep;56(9):4738-45
references: 22733070
references: Expert Rev Anti Infect Ther. 2012 Oct;10(10):1165-76
references: 23199402
references: PLoS Med. 2007 Dec;4(12):e329
references: 18092884
references: Obstet Gynecol Clin North Am. 2008 Jun;35(2):235-48, viii
references: 18486839
references: Cell Microbiol. 2006 Apr;8(4):704-17
references: 16548895
references: J Biomed Biotechnol. 2010;2010:297505
references: 20671958
references: Rev Urol. 2005 Winter;7(1):11-7
references: 16985802
references: Med Clin North Am. 2011 Jan;95(1):27-41
references: 21095409
references: Proc Natl Acad Sci U S A. 2010 May 18;107(20):9072-7
references: 20439758
references: Mol Immunol. 2013 May;54(1):32-9
references: 23220068
references: PLoS Pathog. 2009 Sep;5(9):e1000586
references: 19806177
references: Sci Transl Med. 2011 Nov 16;3(109):109ra115
references: 22089451
references: Nat Rev Urol. 2011 Jul 12;8(8):449-68
references: 21750501
references: Int J Antimicrob Agents. 2010 Apr;35(4):316-21
references: 20060273
references: J Bacteriol. 1985 May;162(2):799-803
references: 2859271
references: Am J Med. 2002 Jul 8;113 Suppl 1A:14S-19S
references: 12113867
references: Cell Microbiol. 2007 Sep;9(9):2230-41
references: 17490405
references: J Urol. 2003 Sep;170(3):867-9
references: 12913718
references: Science. 1997 Apr 25;276(5312):607-11
references: 9110982
references: J Urol. 2007 Apr;177(4):1349-53; quiz 1591
references: 17382730
references: Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17897-902
references: 17098869