title: Recombinant human thrombopoietin alleviates infection-associated thrombocytopenia: a retrospective study in senile patients.
abstract: OBJECTIVE
  To examine the efficacy and adverse events of recombinant human thrombopoietin (rhTPO) in the treatment of infection-associated thrombocytopenia in senile patients.
  
  
  METHODS
  The current study is a retrospective analysis of the patients receiving rhTPO for infection-associated thrombocytopenia in our hospital.
  
  
  RESULTS
  Forty-nine cases were included in the analysis as rhTPO group. The absolute platelet count after treatment, increase in platelet count, and the overall response rate were considerably higher in the rhTPO group than that in the control group. Improvement in bleeding score was higher in the rhTPO treatment group than that in the control group (2.1 ± 5.4 vs 0.4 ± 1.7). Bleeding event was stopped in 68.2% of the patients after rhTPO treatment and in 35% of the patients in the control group (P = .032). A stratified analysis indicated that the therapeutic efficacy is much better in patients without organ failure.
  
  
  CONCLUSIONS
  Recombinant human TPO is effective in alleviating infection-associated thrombocytopenia and hemorrhage in senile patients, particularly if given prior to the emergence of organ failure.
authors: Department of Geriatric Hematology, Chinese PLA General Hospital, Haidian District, Beijing, China.
authors: Jie
authors: J
authors: Lin
authors: Department of Geriatric Hematology, Chinese PLA General Hospital, Haidian District, Beijing, China linjie.online@163.com.
authors: Hongli
authors: H
authors: Zhu
authors: Department of Geriatric Hematology, Chinese PLA General Hospital, Haidian District, Beijing, China.
authors: Suxia
authors: S
authors: Li
authors: Department of Geriatric Hematology, Chinese PLA General Hospital, Haidian District, Beijing, China.
authors: Hui
authors: H
authors: Fan
authors: Department of Geriatric Hematology, Chinese PLA General Hospital, Haidian District, Beijing, China.
authors: Xuechun
authors: X
authors: Lu
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007239:Infections / Q000097:blood / Q000150:complications; D008297:Male; D009102:Multiple Organ Failure / Q000188:drug therapy / Q000209:etiology; D010976:Platelet Count; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D013926:Thrombopoietin / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D013926:Thrombopoietin
keywords: elderly; infection; thrombocytopenia; thrombopoietin