title: Endocytosis of receptor tyrosine kinases.
abstract: Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The canonical model of RTK endocytosis involves rapid internalization of an RTK activated by ligand binding at the cell surface and subsequent sorting of internalized ligand-RTK complexes to lysosomes for degradation. Activation of the intrinsic tyrosine kinase activity of RTKs results in autophosphorylation, which is mechanistically coupled to the recruitment of adaptor proteins and conjugation of ubiquitin to RTKs. Ubiquitination serves to mediate interactions of RTKs with sorting machineries both at the cell surface and on endosomes. The pathways and kinetics of RTK endocytic trafficking, molecular mechanisms underlying sorting processes, and examples of deviations from the standard trafficking itinerary in the RTK family are discussed in this work.
authors: Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
authors: Lai Kuan
authors: LK
authors: Goh
authors: Alexander
authors: A
authors: Sorkin
mesh_terms: D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D020794:Receptor Protein-Tyrosine Kinases / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D054875:Ubiquitination
chemical_list: D020794:Receptor Protein-Tyrosine Kinases
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