title: Regulation of pathogenicity by noncoding RNAs in bacteria.
abstract: Regulatory noncoding RNAs (ncRNAs) play important roles in bacterial gene regulation, primarily at the post-transcriptional level. There are four broad categories of regulatory ncRNAs including trans-encoded ncRNAs, cis-encoded ncRNAs, RNA thermometers and riboswitches, and they can influence the translation and/or stability of mRNAs by binding to the base-pairing sites in their target transcripts. In pathogenic bacteria, numerous ncRNAs are involved in the coordinated expression of virulence determinants to facilitate the pathogenicity in a concerted manner. This review discusses the modes of action of different regulatory ncRNAs and, furthermore, exemplifies their roles in regulating bacterial pathogenicity.
authors: State Key Laboratory of Pathogen & Biosecurity, Beijing Institute of Microbiology & Epidemiology, Beijing 100071, China.
authors: Yanping
authors: Y
authors: Han
authors: Lei
authors: L
authors: Liu
authors: Nan
authors: N
authors: Fang
authors: Ruifu
authors: R
authors: Yang
authors: Dongsheng
authors: D
authors: Zhou
mesh_terms: D001419:Bacteria / Q000235:genetics* / Q000472:pathogenicity*; D015964:Gene Expression Regulation, Bacterial; D020871:RNA Stability; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*; D037521:Virulence Factors / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D022661:RNA, Untranslated; D037521:Virulence Factors