title: Maternal and perinatal factors associated with subsequent meningococcal, Haemophilus or enteroviral meningitis in children: database study.
abstract: We used a database of 248 659 births, with follow-up to subsequent disease, in the Oxford record linkage archive (1979-1999) to study the influence of family, maternal, and perinatal factors on subsequent hospital admission for meningococcal, Haemophilus, and enteroviral meningitis in the children. In this summary, we report key findings that were significant in multivariate analysis. Meningococcal meningitis was significantly associated with maternal smoking [odds ratio (OR) 2·1, 95% confidence interval (CI) 1·2-3·7]. Haemophilus meningitis was associated with having older siblings (e.g. second child compared to first-born, OR 3·3, 95% CI 2·0-5·6). Enteroviral meningitis was associated with low birth weight (OR 2·2, 95% CI 1·3-3·6) and male sex (OR 1·7, 95% CI 1·2-2·3). The mothers of six of the 312 children with enteroviral meningitis had previously had enteroviral meningitis themselves. We concluded that several maternal characteristics influence the risk of these types of meningitis.
authors: Unit of Health-Care Epidemiology, Department of Public Health, University of Oxford, Old Road Campus, Oxford, UK.
authors: M J
authors: MJ
authors: Goldacre
authors: Unit of Health-Care Epidemiology, Department of Public Health, University of Oxford, Old Road Campus, Oxford, UK.
authors: C J
authors: CJ
authors: Wotton
authors: Unit of Health-Care Epidemiology, Department of Public Health, University of Oxford, Old Road Campus, Oxford, UK.
authors: J J
authors: JJ
authors: Maisonneuve
mesh_terms: D000293:Adolescent; D001724:Birth Weight; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure / Q000706:statistics & numerical data; D008583:Meningitis, Haemophilus / Q000453:epidemiology / Q000209:etiology*; D008585:Meningitis, Meningococcal / Q000453:epidemiology / Q000209:etiology*; D008587:Meningitis, Viral / Q000453:epidemiology / Q000209:etiology*; D015999:Multivariate Analysis; D018812:Paternal Exposure / Q000706:statistics & numerical data; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D035781:Siblings; D012907:Smoking / Q000009:adverse effects
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