title: New obesity indices and adipokines in normotensive patients and patients with hypertension: comparative pilot analysis.
abstract: We compared the obesity parameters and selected adipokines-leptin, adiponectin, and resistin-in obese patients with hypertension and normotensive patients. A total of 67 nondiabetic obese outpatients were divided into 2 groups: A-hypertensive and B-normotensive. Serum levels of leptin, adiponectin, resistin, and insulin were measured. Weight, height, waist circumference, and hip circumference were measured to calculate waist-to-hip ratio (WHR), weight-to-height ratio, visceral adiposity index, and body adiposity index (BAI). Among patients with hypertension, significant positive correlations were observed between leptin and body mass index and BAI (r = .31 and r = .63, respectively). In normotensive patients, leptin positively correlated with BAI (r = .73, P < .01) and negatively with WHR (r = -.55, P < .0001); adiponectin negatively correlated with WHR (r = .38, P < .01) and BAI (r = .52; P < .0001), and resistin negatively correlated with WHR (r = -.36, P < .05). In conclusion, visceral obesity and leptin are associated with hypertension in obese patients.
authors: 1Department of Nephrology, Hypertension and Family Medicine, WAM University Hospital in Lodz, Medical University of Lodz, Lodz, Poland.
authors: Mariusz
authors: M
authors: Stepien
authors: Anna
authors: A
authors: Stepien
authors: Maciej
authors: M
authors: Banach
authors: Rafal N
authors: RN
authors: Wlazel
authors: Marek
authors: M
authors: Paradowski
authors: Manfredi
authors: M
authors: Rizzo
authors: Peter P
authors: PP
authors: Toth
authors: Jacek
authors: J
authors: Rysz
mesh_terms: D052242:Adiponectin / Q000097:blood; D050154:Adiposity; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D050152:Intra-Abdominal Fat / Q000503:physiopathology; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D010865:Pilot Projects; D011237:Predictive Value of Tests; D052243:Resistin / Q000097:blood; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; C499624:RETN protein, human; D052243:Resistin
keywords: adipokines; hypertension; obesity; obesity indices