title: [Cyclosporin A-sensitive mitochondrial pore as a target of cardioprotective action of hydrogen sulfide donor].
abstract: In experiments on a model of ischemia-reperfusion in Langendorff isolated rat hearts and isolated mitochondria we studied the role of hydrogen sulfide donor - sodium hydrosulfide (NaHS, 7.4 mg/kg) in modulating the sensitivity ofmitochondrial permeability transition pore opening. It was shown that NaHS increased the reserves of rat myocardium and had cardioprotective effects from ischemia-reperfusion. In experiments on isolated mitochondria NaHS in concentrations of 10(-6), 10(-5) and 5 x 10(-5) mol/L inhibited Ca(2+)-induced swelling of mitochondria. Preincubation of isolated mitochondria with K+(ATphi)-channels inhibitor 5-hydroxydecanoate (10(-4) mol/L) reduced the protective effect of NaHS (10(-5) mol/L). Thus, we consider that NaHS protective effect from reperfusion disturbances of heart function was realized via inhibition of Ca(2+)-induced mitochondrial permeability transition pore opening.
authors: T V
authors: TV
authors: Shimanskaia
authors: N A
authors: NA
authors: Strutinskaia
authors: G L
authors: GL
authors: Vavilova
authors: Iu V
authors: IuV
authors: Goshovskaia
authors: E N
authors: EN
authors: Semenikhina
authors: V F
authors: VF
authors: Sagach
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002316:Cardiotonic Agents / Q000008:administration & dosage; D016572:Cyclosporine / Q000378:metabolism; D003652:Decanoic Acids / Q000494:pharmacology; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006862:Hydrogen Sulfide / Q000008:administration & dosage*; D006880:Hydroxy Acids / Q000494:pharmacology; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000502:physiology; D033681:Mitochondrial Membrane Transport Proteins / Q000187:drug effects* / Q000502:physiology; D000083162:Mitochondrial Permeability Transition Pore; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000503:physiopathology; D009924:Organ Culture Techniques; D024681:Potassium Channels, Calcium-Activated / Q000037:antagonists & inhibitors; D051381:Rats
chemical_list: D002316:Cardiotonic Agents; D003652:Decanoic Acids; D006880:Hydroxy Acids; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D024681:Potassium Channels, Calcium-Activated; C052853:5-hydroxydecanoic acid; D016572:Cyclosporine; D002118:Calcium; D006862:Hydrogen Sulfide