title: Ceftaroline-induced eosinophilic pneumonia.
abstract: We present a case of eosinophilic pneumonia due to ceftaroline used for the treatment of methicillin-resistant Staphylococcus aureus bacteremia associated with a postoperative spinal infection. Our patient developed shortness of breath and hypoxemia on the fifth week of ceftaroline therapy. Chest imaging disclosed diffuse bilateral infiltrates. Laboratory abnormalities included peripheral eosinophilia and eosinophilic predominant bronchoalveolar lavage fluid. The combination of ceftaroline discontinuation plus initiation of steroid treatment resulted in complete resolution of signs, symptoms, and radiologic abnormalities. We speculate about possible mechanisms underlying this adverse event and diagnostic criteria for drug-induced eosinophilic pneumonia.
authors: Miami Valley Hospital, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45409, USA. desaikunalr@hotmail.com
authors: Kunal R
authors: KR
authors: Desai
authors: Steven D
authors: SD
authors: Burdette
authors: Hari M
authors: HM
authors: Polenakovik
authors: Jared
authors: J
authors: Hagaman
authors: Craig M
authors: CM
authors: Pleiman
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002511:Cephalosporins / Q000009:adverse effects* / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D008875:Middle Aged; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy; D000097583:Ceftaroline
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005938:Glucocorticoids; D000097583:Ceftaroline
keywords: adverse event; ceftaroline; eosinophilic pneumonia