title: Guillain-Barré syndrome and variants.
abstract: Guillain-Barré syndrome (GBS) is characterized by rapidly evolving ascending weakness, mild sensory loss, and hyporeflexia or areflexia. Acute inflammatory demyelinating polyneuropathy was the first to be recognized over a century ago and is the most common form of GBS. Axonal motor and sensorimotor variants have been described in the last three decades and are mediated by molecular mimicry targeting peripheral nerve motor axons. Other rare phenotypic variants have been recently described with pure sensory variant, restricted autonomic manifestations, and the pharyngeal-cervical-brachial pattern. It is important to recognize GBS and its variants because of the availability of equally effective therapies in the form of plasmapheresis and intravenous immunoglobulins.
authors: Department of Neurology, University of Kansas Medical Center, 3599 Rainbow Boulevard, Mail Stop 2012, Kansas City, KS 66160, USA. mdimachkie@kumc.edu
authors: Mazen M
authors: MM
authors: Dimachkie
authors: Richard J
authors: RJ
authors: Barohn
mesh_terms: D000328:Adult; D004568:Electrodiagnosis; D005260:Female; D017408:Guidelines as Topic; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D010951:Plasma Exchange / Q000379:methods
chemical_list: D016756:Immunoglobulins, Intravenous
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