title: Increase in left liver lobe function after preoperative right portal vein embolisation assessed with gadolinium-EOB-DTPA MRI.
abstract: OBJECTIVE
  To prospectively evaluate the early development of regional liver function after right portal vein embolisation (PVE) with Gd-EOB-DTPA-enhanced MRI in patients scheduled for extended right hemihepatectomy.
  
  
  METHODS
  Ten patients who received a PVE before an extended hemihepatectomy were examined before and 14 days after PVE using Gd-EOB-DTPA-enhanced MRI of the liver. In these sequences representative region of interest measurements were performed in the embolised right (RLL) and the non-embolised left liver lobe (LLL). The volume as well as hepatic uptake index (HUI) was calculated independently for each lobe.
  
  
  RESULTS
  Relative enhancement 14 days after PVE decreased in the RLL and increased significantly in the LLL (P < 0.05). Average hepatic uptake index (HUI) for RLL was significantly lower 14 days after PVE than before PVE (P < 0.05) and significantly higher for LLL (P < 0.05).
  
  
  CONCLUSIONS
  A significant shift of contrast uptake from the right to the left liver lobe can be depicted as early as 14 days after right PVE by using Gd-EOB-DTPA-enhanced MRI, which could reflect the redirected portal venous blood flow and the rapid utilisation of a hepatic functional reserve.
  
  
  CONCLUSIONS
  • Preoperative portal vein embolisation (PVE) is widely performed before right-sided hepatic resection. • PVE increases intravenous contrast medium uptake in the left lobe of liver. • The hepatic uptake index for the left liver lobe increases rapidly after PVE. • Left liver lobe function increase may be visualised by Gd-EOB-DTPA-enhanced MRI.
authors: Department of Diagnostic and Interventional Radiology, Charité, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany. dominik.geisel@charite.de
authors: Dominik
authors: D
authors: Geisel
authors: Lutz
authors: L
authors: Lüdemann
authors: Thomas
authors: T
authors: Keuchel
authors: Maciej
authors: M
authors: Malinowski
authors: Daniel
authors: D
authors: Seehofer
authors: Martin
authors: M
authors: Stockmann
authors: Bernd
authors: B
authors: Hamm
authors: Bernhard
authors: B
authors: Gebauer
authors: Timm
authors: T
authors: Denecke
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D018281:Cholangiocarcinoma / Q000503:physiopathology*; D003287:Contrast Media / Q000493:pharmacokinetics*; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D019786:Gadolinium DTPA / Q000493:pharmacokinetics*; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008099:Liver / Q000503:physiopathology*; D008113:Liver Neoplasms / Q000503:physiopathology* / Q000556:secondary*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000473:pathology; D011446:Prospective Studies
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
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