title: Late acute myopia syndrome induced by combination of sulfonamide drugs.
abstract: We present a case of late acute myopia syndrome following discontinuation of treatment with a combination of sulphonamide drugs. To the best of our knowledge, this is the first reported case with such a presentation, and suggests that the pathophysiological basis for the acute myopia syndrome is a rapid decrease in serum carbonic anhydrase inhibitors levels which may lead to a rebound increase in the production of aqueous humor and accumulation of suprachoroidal fluid. It is further postulated that there may be a cumulative effect of sulphonamide drug use on carbonic anhydrase activity in the ciliary body epithelium of susceptible individuals.
authors: *Department of Ophthalmology, Hospital Na Bulovce, Prague, Czech Republic †Department of Opthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA.
authors: Pavel
authors: P
authors: Kozner
authors: Katarina
authors: K
authors: Simonova
authors: Bretislav
authors: B
authors: Brozek
authors: Kuldev
authors: K
authors: Singh
mesh_terms: D000208:Acute Disease; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D000927:Anticonvulsants / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008881:Migraine Disorders / Q000517:prevention & control; D009216:Myopia / Q000139:chemically induced* / Q000175:diagnosis; D010612:Pharyngitis / Q000188:drug therapy; D000077236:Topiramate; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
chemical_list: D000890:Anti-Infective Agents; D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose; D015662:Trimethoprim, Sulfamethoxazole Drug Combination