title: [Manufacturing process of high quality phytopreparation on example of herbal sedative].
abstract: BACKGROUND
  Rational phytotherapy is a modern concept of using plant-originated drugs which has emerged from the need to improve phytotherapy in order to make the use of herbal remedies more efficient and safer. The aim of this study was to give the health-care workers more information on the manufacturing process of high quality phytopreparation following principles of Good Manufacturing Practice and Good Laboratory Practice on the example of herbal sedative, Odoval S capsules.
  
  
  METHODS
  This study was designed to reflect the production process of a high-quality and safe herbal remedy, starting from defining the formulation and the production procedure to the quality control of raw materials, characterization of the final product, and testing stability of active ingredients in the capsules.
  
  
  RESULTS
  Formulation of the phytopreparation, validation of the production process, quality control and stability testing, all together have resulted in the production of capsules with defined valeric acid content (1 mg valeric acid per capsule).
  
  
  CONCLUSIONS
  The preparation is recommended to relieve the symptoms caused by chronic stress (anxiety, irritability, fatigue, lack of concentration, heart palpitations) and for mild insomnia.
  
  
  CONCLUSIONS
  This paper presents the complete cycle of the production of a phytopreparation on the example of a new herbal sedative--Odoval S capsules.
authors: Institut za proucavenje lekovitog bilja Dr Josif Pancić, Klinicki centar Vojvodine, Novi Sad. sdjordjevic@mocbilja.rs
authors: Sofija
authors: S
authors: Dordević
authors: Aleksandra
authors: A
authors: Dickov
authors: Sava
authors: S
authors: Pavkov
authors: Vanja
authors: V
authors: Tadić
authors: Ivana
authors: I
authors: Arsić
authors: Ana
authors: A
authors: Zugić
mesh_terms: D006801:Humans; D006993:Hypnotics and Sedatives / Q000592:standards*; D008517:Phytotherapy; D028321:Plant Preparations / Q000592:standards*; D011786:Quality Control; D014632:Valerian
chemical_list: D006993:Hypnotics and Sedatives; D028321:Plant Preparations