title: Stromal response in different histological grades of oral squamous cell carcinoma: a histochemical study.
abstract: OBJECTIVE
  The aim of the study is to evaluate the connective tissue changes in different grades of Oral Squamous Cell Carcinoma (OSCC's) and the influence of these changes in predicting the biological behavior of these tumors.
  
  
  METHODS
  A total of 39 cases of OSCC's and 6 sections of controls were examined using seven connective tissue special histochemical stains.
  
  
  RESULTS
  Staining intensity of collagen, reticulin, acid mucins, fibrin, glycoproteins, sulfated mucins, elastic fibers around the tumor islands and within the connective tissue was observed.
  
  
  CONCLUSIONS
  Tumor cells which grow progressively in the host stroma have the capacity to pre-empt and subvert the response of host, which is essential for their growth and spread.
  
  
  CONCLUSIONS
  The reactive changes in the tumor stroma may alter the biological aggressiveness of oral cancer, and by incorporating this concept into a prognostic system, we may help to reflect the biologic diversity of oral cancer and predict its clinical outcomes.
authors: Department of Oral Pathology and Microbiology, Babu Banarasi Das College of Dental Sceinces, Faizabad Road, Lucknow, Uttar Pradesh, India.
authors: Jiji
authors: J
authors: George
authors: Ramandeep Singh
authors: RS
authors: Narang
authors: Nirmala N
authors: NN
authors: Rao
mesh_terms: D000423:Alcian Blue; D001391:Azo Compounds; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003094:Collagen / Q000032:analysis; D004396:Coloring Agents; D003238:Connective Tissue / Q000473:pathology; D004547:Elastic Tissue / Q000473:pathology; D005337:Fibrin / Q000032:analysis; D006023:Glycoproteins / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D009062:Mouth Neoplasms / Q000473:pathology*; D009077:Mucins / Q000032:analysis; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D010503:Periodic Acid-Schiff Reaction; D012155:Reticulin / Q000032:analysis; D012394:Rosaniline Dyes; D016622:Silver Staining; D017154:Stromal Cells / Q000473:pathology*
chemical_list: D001391:Azo Compounds; D004396:Coloring Agents; D006023:Glycoproteins; D009077:Mucins; D012155:Reticulin; D012394:Rosaniline Dyes; D005337:Fibrin; D003094:Collagen; C042643:Martius scarlet blue trichrome; D000423:Alcian Blue