title: Random measurements of adiponectin and IL-6 may not be indicative of the 24-h profile in critically ill patients.
abstract: BACKGROUND
  The anti-inflammatory role of adiponectin has prompted interest in a potential role in acute inflammatory conditions associated with critical illness. It is unclear whether a random adiponectin measurement adequately reflects the 24-h profile in critically ill patients.
  
  
  OBJECTIVE
  To assess the temporal profile of total and high molecular weight (HMW) adiponectin and interleukin-6 (IL-6) in 15 critically ill patients.
  
  
  METHODS
  A prospective, observational study.
  
  
  METHODS
  Level II intensive care unit in a metropolitan hospital.
  
  
  METHODS
  Fifteen critically ill patients expected to stay in the ICU for longer than 48 h were eligible for enrolment.
  
  
  METHODS
  None.
  
  
  METHODS
  Serial, hourly measurements of total and HMW adiponectin and IL-6.
  
  
  RESULTS
  Over a 24-h period, total and HMW adiponectin display considerable within-patient variability (coefficient of variation 34% and 87% respectively) and show no trend over time. Averaging 2 or 3 continuous measures reduced within-patient variability of both total and HMW adiponectin by up to 50% compared to one measure. There was a negative correlation between serum glucose and adiponectin (total P = 0·016, HMW P = 0·039). No relationship existed between adiponectin and IL-6 (total P = 0·62, HMW P = 0·35).
  
  
  CONCLUSIONS
  Marked within-patient, hourly variability in total and HMW adiponectin is evident in critically ill patients. A random measurement may not be reflective of the 24-h profile in these patients. A negative correlation exists between adiponectin and blood glucose levels and a positive correlation between adiponectin and oxygen saturation. No clear relationship exists between adiponectin and IL-6.
authors: Intensive Care Unit, The Wesley Hospital, University of Queensland, Brisbane, Australia.
authors: Katherine
authors: K
authors: Robinson
authors: Mark
authors: M
authors: Jones
authors: Jenny
authors: J
authors: Ordonez
authors: Jeffrey
authors: J
authors: Grice
authors: Ben
authors: B
authors: Davidson
authors: John
authors: J
authors: Prins
authors: Bala
authors: B
authors: Venkatesh
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002940:Circadian Rhythm; D016638:Critical Illness; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D011446:Prospective Studies
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6