title: Moderate alcohol consumption predicts long-term mortality in elderly subjects with chronic heart failure.
abstract: OBJECTIVE
  Moderate alcohol consumption is related to a reduction of mortality. However, this phenomenon is not well established in the elderly, especially in the presence of chronic heart failure (CHF). The aim of the study was to verify the effect of moderate alcohol consumption on 12-year mortality in elderly community-dwelling with and without CHF.
  
  
  METHODS
  community-dwelling from 5 regions of Italy.
  
  
  METHODS
  A cohort of 1332 subjects aged 65 and older.
  
  
  METHODS
  Mortality after 12-year follow-up in elderly subjects (≥65 years old) with and without CHF was studied. Moderate alcohol consumption was considered ≤250 ml/day (drinkers).
  
  
  RESULTS
  In the absence of CHF (n=947), mortality was 42.2% in drinkers vs. 53.7% in non-drinker elderly subjects (p=0.021). In contrast, in the presence of CHF (n=117), mortality was 86.5% in drinkers vs. 69.7% in non-drinker elderly subjects (p=0.004). Accordingly, Cox regression analysis shows that a moderate alcohol consumption is protective of mortality in the absence (HR=0.79; CI 95% 0.66-0.95; p<0.01) but it is predictive of mortality in the presence of CHF (HR=1.29; CI 95% 1.05-1.97; p<0.05).
  
  
  CONCLUSIONS
  Our data demonstrates that moderate alcohol consumption is associated with an increased long-term mortality risk in the elderly in the presence of CHF.
authors: Dipartimento di Medicina Clinica e Scienze Cardiovascolari ed Immunologiche, Cattedra di Geriatria, University of Naples Federico II, 80131 Napoli, Italy.
authors: G
authors: G
authors: Gargiulo
authors: G
authors: G
authors: Testa
authors: F
authors: F
authors: Cacciatore
authors: F
authors: F
authors: Mazzella
authors: G
authors: G
authors: Galizia
authors: D
authors: D
authors: Della-Morte
authors: A
authors: A
authors: Langellotto
authors: G
authors: G
authors: Pirozzi
authors: G
authors: G
authors: Ferro
authors: N
authors: N
authors: Ferrara
authors: F
authors: F
authors: Rengo
authors: P
authors: P
authors: Abete
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000401:mortality*; D002908:Chronic Disease; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006333:Heart Failure / Q000401:mortality*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D016016:Proportional Hazards Models
chemical_list: D000431:Ethanol
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