title: Papillary meningioma: clinical and histopathological observations.
abstract: Papillary meningioma is a rare subtype of malignant meningiomas, which is classified by the World Health Organization as Grade III. Because of lack of large sample size case studies, many of the specific characteristics of papillary meningioma are unclear. This study investigated by retrospective analysis the clinical, radiological and histopathological findings of 17 papillary meningioma patients who underwent surgical resection or biopsy, to assess the characteristics of papillary meningioma. Eight female and nine male patients were included, with a mean age of 40 (range: 6 to 55) years. Tumors were mostly located in the cerebral convexity and showed irregular margins, absence of a peritumoral rim, heterogeneous enhancement and severe peritumoral brain edema on preoperative images. Brain invasion was often confirmed during the operations, with abundant to exceedingly abundant blood supply. Intratumoral necrosis and mitosis was frequently observed on routinely stained sections. The average MIB-1 labeling index was 6.9%. Seven cases experienced tumor recurrence or progression, while seven patients died 6 to 29 months after operation. Radiation therapy was given in 52.9% of all cases. Univariate analysis showed that only the existence of intratumoral necrosis and incomplete resection correlated with tumor recurrence. The 3-year progression free survival was 66.7% after gross total resection and 63.6% for other cases. The 3-year mortality rate was 50% after gross total resection and 63.6% for other cases. Papillary meningioma has specific clinical and histopathological characteristics. Tumor recurrence (or progression) and mortality are common. Gross total tumor resection resulted in less recurrence and mortality.
authors: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Dai-Jun
authors: DJ
authors: Wang
authors: Ming-Zhe
authors: MZ
authors: Zheng
authors: Ye
authors: Y
authors: Gong
authors: Qing
authors: Q
authors: Xie
authors: Yin
authors: Y
authors: Wang
authors: Hai-Xia
authors: HX
authors: Cheng
authors: Ying
authors: Y
authors: Mao
authors: Ping
authors: P
authors: Zhong
authors: Xiao-Ming
authors: XM
authors: Che
authors: Cheng-Chuan
authors: CC
authors: Jiang
authors: Feng-Ping
authors: FP
authors: Huang
authors: Kang
authors: K
authors: Zheng
authors: Shi-Qi
authors: SQ
authors: Li
authors: Yu-Xiang
authors: YX
authors: Gu
authors: Wei-Min
authors: WM
authors: Bao
authors: Bo-Jie
authors: BJ
authors: Yang
authors: Jing-Song
authors: JS
authors: Wu
authors: Li-Qian
authors: LQ
authors: Xie
authors: Hai-Liang
authors: HL
authors: Tang
authors: Hong-Da
authors: HD
authors: Zhu
authors: Xian-Cheng
authors: XC
authors: Chen
authors: Liang-Fu
authors: LF
authors: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008577:Meningeal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008579:Meningioma / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D019635:Neurosurgical Procedures; D011379:Prognosis; D011878:Radiotherapy; D012189:Retrospective Studies; D055815:Young Adult
keywords: Papillary meningioma; clinical manifestations; histopathology; prognosis
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