title: Primary amines as directing groups in the Ru-catalyzed synthesis of isoquinolines, benzoisoquinolines, and thienopyridines.
abstract: Isoquinolines, benzoisoquinolines, thieno[3,2-c]pyridines and fused heteroaryl[2,3-c] pyridines, with a wide variety of substituents at different positions of the aromatic or heteroaromatic rings, have been synthesized by Ru-catalyzed oxidative coupling of a broad range of benzylamines or heterocycles with internal alkynes. All benzylamines and heterocycles have unprotected primary amines as efficient directing groups.
authors: Instituto de Síntesis Quimica y Catálisis Homogénea, CSIC-Universidad de Zaragoza, Pedro Cerbuna 12, 50009 Zaragoza, Spain.
authors: Pedro
authors: P
authors: Villuendas
authors: Esteban P
authors: EP
authors: Urriolabeitia
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D058924:Thienopyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D007546:Isoquinolines; D009942:Organometallic Compounds; D058924:Thienopyridines; D012428:Ruthenium