title: Optimization of continuous infusion of piperacillin-tazobactam in children with fever and neutropenia.
abstract: The study through Monte Carlo simulation of β-lactam pharmacokinetic/pharmacodynamic target attainment and determination of subsequent serum concentrations of piperacillin-tazobactam administered through continuous infusion to children treated for fever and neutropenia shows that 400 mg/kg/day has the highest probability of target attainment against Pseudomonas aeurginosa in our oncology ward compared with the standard regimen of 300 mg/kg/day.
authors: From the *Laboratoire de Bactériologie Hygiène, Institut de Microbiologie, Centre de Biologie Pathologie; †Université Lille Nord de France; ‡Hématologie Pédiatrique, Hôpital Jeanne de Flandres; §Réanimation Chirurgicale, Hôpital Claude Huriez, CHRU de Lille; and ¶Pseudomonas aeruginosa Host-pathogen Translational Research Group, Lille School of Medicine, UDSL, Lille North of France University, Lille, France.
authors: Mélanie
authors: M
authors: Delvallée
authors: Françoise
authors: F
authors: Mazingue
authors: Wadi
authors: W
authors: Abouchahla
authors: Mathilde
authors: M
authors: Delebarre
authors: Frédéric
authors: F
authors: Wallet
authors: René
authors: R
authors: Courcol
authors: Eric
authors: E
authors: Kipnis
authors: Rodrigue
authors: R
authors: Dessein
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000494:pharmacology; D002648:Child; D005260:Female; D005335:Fever of Unknown Origin / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D008297:Male; D009503:Neutropenia / Q000188:drug therapy*; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D010878:Piperacillin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D000077725:Piperacillin, Tazobactam Drug Combination; D011552:Pseudomonas Infections / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin