title: Colorimetric and fluorometric detection of neomycin based on conjugated polydiacetylene supramolecules.
abstract: Utilizing the colorimetric and fluorogenic changes, a system based on polydiacetylenes (PDAs) is developed for the detection of neomycin. The PDA supramolecules polymerized from the mixed liposome composed of N-(3-hydroxyphenyl)pentacosa-10,12-diynamide (PCDA-AP) and pentacosa-10,12-diynoic acid (PCDA) at an optimized ratio of 1:9 display a unique colorimetric change (blue to red) and fluorescent enhancement in the presence of neomycin. The detection limit for neomycin is estimated to be 2.55 × 10(-7) M by the fluorogenic method. The optical changes induced by neomycin can be attributed to the disruption of the hydrogen bonding between phenol and carboxylic acid from PCDA-AP and PCDA.
authors: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing 210009, China.
authors: Guodong
authors: G
authors: Zhou
authors: Fang
authors: F
authors: Wang
authors: Huilin
authors: H
authors: Wang
authors: Srinivasulu
authors: S
authors: Kambam
authors: Xiaoqiang
authors: X
authors: Chen
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis*; D015374:Biosensing Techniques; D003124:Colorimetry / Q000295:instrumentation / Q000379:methods*; D005470:Fluorometry / Q000295:instrumentation / Q000379:methods*; D008081:Liposomes / Q000737:chemistry; D009355:Neomycin / Q000032:analysis*; D000078789:Polyacetylene Polymer; D011108:Polymers / Q000737:chemistry*; D053279:Polyynes / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D008081:Liposomes; D000078789:Polyacetylene Polymer; D011108:Polymers; D053279:Polyynes; C082361:polydiacetylene; D009355:Neomycin