title: Antiepileptic effect of dimethyl sulfoxide in a rat model of temporal lobe epilepsy.
abstract: Dimethyl sulfoxide (DMSO) is an amphipathic molecule widely used to solubilize water-insoluble compounds. In many studies it was reported that DMSO is capable of affecting several biological processes, thus resulting in a potential cause for the misinterpretation of experimental data. Recent papers showed that DMSO modified the brain bioelectric activity in animal models of epilepsy. In an in vivo model of temporal lobe epilepsy in the rat, we examined the effects of different doses (10%, 50% and 100%) of DMSO on the maximal dentate activation (MDA). The results show that DMSO induced a dose-dependent significant reduction of the electrically induced paroxysmal activity.
authors: Dipartimento di Bio-Medicina sperimentale e Neuroscienze cliniche, Sezione di Fisiologia umana G. Pagano, Università degli Studi di Palermo, Corso Tukory, 129, 90134 Palermo, Italy. fabio.carletti@unipa.it
authors: Fabio
authors: F
authors: Carletti
authors: Giuseppe
authors: G
authors: Ferraro
authors: Valerio
authors: V
authors: Rizzo
authors: Carla
authors: C
authors: Cannizzaro
authors: Pierangelo
authors: P
authors: Sardo
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage*; D002529:Cerebellar Nuclei / Q000187:drug effects* / Q000503:physiopathology*; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy*; D006801:Humans; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D004121:Dimethyl Sulfoxide