title: Decreased serum interleukin 27 in Brazilian systemic lupus erythematosus patients.
abstract: The immunological role of interleukin 27 has been reported in various inflammatory diseases, but its importance in systemic lupus erythematosus pathogenesis is not completely established. The aim of this study was to evaluate serum levels of IL-27 in SLE patients and its correlation with clinical manifestations and disease activity. IL-27 levels were assessed in 70 SLE patients and 30 healthy controls by ELISA. Clinical and laboratory parameters were recorded. Statistic analyzes were performed by Graph Prism 3.02 software. The IL-27 serum levels were significantly decreased in SLE patients compared with controls (mean 899.92 and 1,531.22 pg/ml, P=0.0005). There was a correlation between IL-27 levels and C3 levels (P=0.004). Nevertheless, there was no association of serum IL-27 levels with disease activity evaluated by SLEDAI score (P=0.9605). No significant difference was found regarding IL-27 levels between SLE patients with and without nephritis, haematuria, proteinuria and positive anti-dsDNA. Correlation analysis between serum IL-27 levels and SLEDAI, SLICC, proteinuria levels, C4 and CH50 levels also showed no association. These data demonstrated decreased serum levels of IL-27 in SLE patients but further studies are needed to clarify the precise role of this cytokine and its potential use as therapeutic target.
authors: Hospital das Clínicas, Universidade Federal de Pernambuco, Recife, PE, Brazil.
authors: Angela Luzia Branco Pinto
authors: AL
authors: Duarte
authors: Andréa Tavares
authors: AT
authors: Dantas
authors: Henrique
authors: H
authors: de Ataíde Mariz
authors: Flaviana Alves
authors: FA
authors: dos Santos
authors: Juliana Cruz
authors: JC
authors: da Silva
authors: Laurindo Ferreira
authors: LF
authors: da Rocha
authors: Suely Lins
authors: SL
authors: Galdino
authors: Maira
authors: M
authors: Galdino da Rocha Pitta
mesh_terms: D000328:Adult; D001938:Brazil; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
chemical_list: D007378:Interleukins; C464565:MYDGF protein, human
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