title: Deep tissue flowmetry based on diffuse speckle contrast analysis.
abstract: Diffuse correlation spectroscopy (DCS) is an emerging modality for noninvasive deep tissue blood flow monitoring that is becoming increasingly popular; it conducts an autocorrelation analysis of fast fluctuating photon count signals from a single speckle. In this Letter, we show that the same level of deep tissue flow information can be obtained from a much simpler analysis on the spatial distribution of the speckles that is obtained by a CCD camera, which we named diffuse speckle contrast analysis (DSCA). Both the flow phantom experiment and in vivo cuff occlusion data are presented. DSCA can be considered a new optical modality that combines DCS and laser speckle contrast imaging (LSCI), which exploits simple instrumentation and analysis and yet is sensitive to deep tissue flow.
authors: School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore.
authors: Renzhe
authors: R
authors: Bi
authors: Jing
authors: J
authors: Dong
authors: Kijoon
authors: K
authors: Lee
mesh_terms: D001775:Blood Circulation; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D019047:Phantoms, Imaging; D012212:Rheology; D013057:Spectrum Analysis