title: Risk factors associated with unconjugated neonatal hyperbilirubinemia in Malaysian neonates.
abstract: OBJECTIVE
  To investigate the risk factors associated with neonatal hyperbilirubinemia in Malaysian neonates.
  
  
  METHODS
  A prospective study was conducted to investigate the effects of glucose-6-phosphate dehydrogenase (G6PD) mutation, variant uridine diphosphate glucuronosyltransferase UGT1A1 gene and hepatic organic anion transporter protein (OATP2) gene on a group of neonates. Hyperbilirubinemia was defined as a total serum bilirubin level of ≥250 µmol/l.
  
  
  RESULTS
  Of 318 neonates, 52 (16.4%) had hyperbilirubinemia. The incidence of G6PD mutation was 5.4% (15/280) among these infants. The incidence of G6PD mutation was significantly higher in the male neonates with hyperbilirubinemia (7.8%) when compared with the normal male neonates without hyperbilirubinemia (1.8%; p = 0.03). Logistic regression analysis showed that the significant risk factors for neonatal hyperbilirubinemia were Malay ethnicity [adjusted odds ratio (OR), 2.77; 95% confidence interval (CI): 1.31-5.86; p = 0.007] and G6PD mutation (adjusted OR, 3.29; 95% CI: 1.06-10.1820; p = 0.039). The gender, birth weight and gestation age of neonates, variant c.211G > A and variant of OATP2 gene were not significant.
  
  
  CONCLUSIONS
  Neonates with Malay ethnicity and G6PD mutation were at risk for hyperbilirubinemia.
authors: Unit NICU, Department of Pediatrics, UKMMC, 56000, Kuala Lumpur, Malaysia. feiliang@gmail.com
authors: Feiliang
authors: F
authors: Wong
authors: NemYun
authors: N
authors: Boo
authors: Ainoon
authors: A
authors: Othman
mesh_terms: D044466:Asian People / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000208:ethnology* / Q000235:genetics; D015994:Incidence; D007231:Infant, Newborn; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D009154:Mutation; D027361:Organic Anion Transporters / Q000235:genetics*; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D000099148:UGT1A1 Enzyme
chemical_list: D005954:Glucosephosphate Dehydrogenase; D014453:Glucuronosyltransferase; D027361:Organic Anion Transporters; D000099148:UGT1A1 Enzyme
keywords: G6PD mutation; OATP2; UGT1A1 c.211G > A; neonatal hyperbilirubinemia