title: Systemic treatment of liver metastases from colorectal cancer.
abstract: Patients presenting with synchronous or metachronous colorectal cancer liver metastases (CLM) should be evaluated for multimodal management with curative intent. Preoperative systemic chemotherapy shows beneficial impact on adjuvant progression-free survival and also borderline on overall survival, without significantly increasing initially R0 resectable patients postoperative complication rates. Postoperative chemotherapy recommended based on the perioperative trial experience for those patients achieving at least stable disease during preoperative chemotherapy, or based on the adjuvant trials for patients receiving upfront resection. 'Borderline' resectable CLM, preoperative chemotherapy plays an important role in both in achievement of a resectable status and improvement of prognosis. Recent 4 drug combinations demonstrated response rates up to 80% even for advanced disease and are thus promising regimens for further evaluation in patients with resectable or unresectable liver-limited (+/- lung) disease.
authors: Department of Oncology, Hematology, BMT with Section Pneumology, Hubertus Wald Tumour Centre, University Cancer Centre Hamburg, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
authors: Alexander
authors: A
authors: Stein
authors: Hans-Joachim
authors: HJ
authors: Schmoll
keywords: colorectal liver metastases; induction treatment; perioperative; resectability
references: J Clin Oncol. 2009 Feb 10;27(5):672-80
references: 19114685
references: Ann Surg Oncol. 2012 Feb;19(2):435-42
references: 21743977
references: J Clin Oncol. 2006 Nov 1;24(31):4976-82
references: 17075115
references: Dig Surg. 2011;28(2):114-20
references: 21540596
references: Br J Cancer. 2010 Nov 9;103(10):1542-7
references: 20959822
references: Eur J Cancer. 2012 Jul;48(10):1466-75
references: 22446022
references: Ann Oncol. 2009 Jun;20(6):985-92
references: 19153115
references: Eur J Surg Oncol. 2012 Mar;38(3):259-65
references: 22209659
references: J Clin Oncol. 2011 Jul 1;29(19):2675-82
references: 21646616
references: J Clin Oncol. 2008 Aug 1;26(22):3672-80
references: 18669451
references: J Clin Oncol. 2007 May 1;25(13):1670-6
references: 17470860
references: J Clin Oncol. 2008 Oct 20;26(30):4906-11
references: 18794541
references: N Engl J Med. 2009 Jul 2;361(1):98-9
references: 19571295
references: Oncologist. 2011;16(11):1557-64
references: 22016477
references: N Engl J Med. 2004 Jun 3;350(23):2335-42
references: 15175435
references: Lancet. 2008 Mar 22;371(9617):1007-16
references: 18358928
references: J Clin Oncol. 2009 Jul 1;27(19):3117-25
references: 19451425
references: Ann Oncol. 2012 Oct;23(10):2479-2516
references: 23012255
references: Cancer. 2007 Dec 15;110(12):2761-7
references: 17960603
references: J Clin Oncol. 2008 Nov 10;26(32):5254-60
references: 18854565
references: Br J Surg. 2011 Mar;98(3):399-407
references: 21254017
references: Ann Surg. 2008 Oct;248(4):626-37
references: 18936576
references: Hepatogastroenterology. 2008 Jan-Feb;55(81):173-8
references: 18507101
references: Ann Oncol. 2014 Jul;25(7):1346-1355
references: 24718886
references: Cancer. 2011 Mar 15;117(6):1296-301
references: 21381016
references: J Clin Oncol. 2008 Apr 10;26(11):1830-5
references: 18398148
references: Ann Surg. 2009 Sep;250(3):440-8
references: 19730175
references: Ann Oncol. 2007 Feb;18(2):299-304
references: 17060484
references: Ann Oncol. 2011 Jul;22(7):1535-1546
references: 21228335
references: Ann Surg. 1999 Sep;230(3):309-18; discussion 318-21
references: 10493478
references: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references: 21296855
references: J Clin Oncol. 2008 Nov 20;26(33):5344-51
references: 18936472
references: Lancet. 2011 Jun 18;377(9783):2103-14
references: 21641636
references: Int J Cancer. 2010 Dec 15;127(12):2893-917
references: 21351269
references: Br J Surg. 2010 Jul;97(7):1110-8
references: 20632280
references: Ann Oncol. 2011 Sep;22(9):2042-2048
references: 21285134
references: Ann Surg Oncol. 2010 Aug;17(8):2059-65
references: 20177795
references: J Clin Oncol. 2008 Oct 10;26(29):4828-33
references: 18711170
references: Lancet Oncol. 2010 Jan;11(1):38-47
references: 19942479
references: Cancer Chemother Pharmacol. 2008 Jul;62(2):195-201
references: 17901955
references: Ann Surg Oncol. 2009 Sep;16(9):2385-90
references: 19554377
references: Ann Oncol. 2010 Jun;21 Suppl 6:vi1-10
references: 20534623
references: J Clin Oncol. 2009 Aug 1;27(22):3677-83
references: 19470929
references: J Clin Oncol. 2011 Jan 1;29(1):11-6
references: 20940184
references: BMC Cancer. 2010 Oct 19;10:567
references: 20958992
references: J Clin Oncol. 2011 May 20;29(15):2011-9
references: 21502544
references: Ann Surg. 2008 Jan;247(1):118-24
references: 18156931
references: Colorectal Dis. 2012 Jan;14(1):56-61
references: 21176063
references: Surgery. 1986 Aug;100(2):278-84
references: 3526605
references: Ann Oncol. 2009 Apr;20(4):674-80
references: 19179549
references: Cancer. 2013 Dec 1;119(23):4137-44
references: 24104864
references: J Clin Oncol. 2006 May 1;24(13):2065-72
references: 16648507
references: Lancet Oncol. 2010 Sep;11(9):845-52
references: 20702138
references: Lancet. 2007 Jul 14;370(9582):105-107
references: 17630019
references: Eur J Cancer. 2014 Jan;50(1):57-63
references: 24138831
references: J Surg Oncol. 2012 Aug 1;106(2):123-9
references: 22331825
references: BMC Cancer. 2010 Oct 11;10:545
references: 20937118
references: Eur J Surg Oncol. 2011 Apr;37(4):336-43
references: 21277151
references: J Clin Oncol. 2007 Aug 10;25(23):3456-61
references: 17687149
references: N Engl J Med. 2009 Feb 5;360(6):563-72
references: 19196673
references: Ann Oncol. 2009 Dec;20(12):1964-70
references: 19567451
references: Lancet Oncol. 2012 Dec;13(12):1225-33
references: 23168362
references: Ann Surg. 2006 Jan;243(1):1-7
references: 16371728
references: Ann Surg Oncol. 2010 Nov;17(11):2870-6
references: 20567921
references: J Clin Oncol. 2008 Apr 20;26(12):2013-9
references: 18421054
references: J Clin Oncol. 2006 Nov 1;24(31):4983-90
references: 17075116
references: J Clin Oncol. 2006 Aug 20;24(24):3939-45
references: 16921046