title: A change in SHATTERPROOF protein lies at the origin of a fruit morphological novelty and a new strategy for seed dispersal in medicago genus.
abstract: Angiosperms are the most diverse and numerous group of plants, and it is generally accepted that this evolutionary success owes in part to the diversity found in fruits, key for protecting the developing seeds and ensuring seed dispersal. Although studies on the molecular basis of morphological innovations are few, they all illustrate the central role played by transcription factors acting as developmental regulators. Here, we show that a small change in the protein sequence of a MADS-box transcription factor correlates with the origin of a highly modified fruit morphology and the change in seed dispersal strategies that occurred in Medicago, a genus belonging to the large legume family. This protein sequence modification alters the functional properties of the protein, affecting the affinities for other protein partners involved in high-order complexes. Our work illustrates that variation in coding regions can generate evolutionary novelties not based on gene duplication/subfunctionalization but by interactions in complex networks, contributing also to the current debate on the relative importance of changes in regulatory or coding regions of master regulators in generating morphological novelties.
authors: Instituto de Biología Molecular y Celular de Plantas, Universidad Politécnica de Valencia-Consejo Superior de Investigaciones Científicas, 46022 Valencia, Spain.
authors: Chloé
authors: C
authors: Fourquin
authors: Carolina
authors: C
authors: del Cerro
authors: Filipe C
authors: FC
authors: Victoria
authors: Aurélie
authors: A
authors: Vialette-Guiraud
authors: Antonio C
authors: AC
authors: de Oliveira
authors: Cristina
authors: C
authors: Ferrándiz
mesh_terms: D019143:Evolution, Molecular; D005638:Fruit / Q000502:physiology; D029902:Medicago / Q000502:physiology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*; D011110:Polymorphism, Genetic; D058614:Seed Dispersal / Q000502:physiology*; D012639:Seeds / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D010940:Plant Proteins; D014157:Transcription Factors
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