title: Mitochondrial changes in adenocarcinoma of the pancreas.
abstract: The aim of our study was to analyse the mitochondrial ultrastructure in primary ductal adenocarcinomas of the pancreas and to compare it with normal pancreatic cells. 52 samples of adenocarcinoma of the pancreas obtained by surgical resection or by endosonographic biopsy were examined. Compared to normal mitochondrial ultrastructure in non-tumorous cells, the mitochondria in cancer cells had a dense matrix and condensed configuration or with lucent-swelling matrix associated with disarrangement and distortion of cristae and partial or total cristolysis. Functionally, these structural alterations presume the presence of hypoxia-tolerant and hypoxia-sensitive cancer cells.
authors: Laboratory of Microscopic Methods, Faculty of Medicine and Dentistry, Palacký University in Olomouc, Hněvotínská 3, Olomouc, Czech Republic. rnovot@centrum.cz
authors: Radko
authors: R
authors: Novotný
authors: Jiří
authors: J
authors: Ehrmann
authors: Igor
authors: I
authors: Tozzi di Angelo
authors: Vlastimil
authors: V
authors: Procházka
authors: Dušan
authors: D
authors: Klos
authors: Martin
authors: M
authors: Loveček
authors: Jiří
authors: J
authors: Kysučan
authors: Roman
authors: R
authors: Havlík
mesh_terms: D001706:Biopsy; D021441:Carcinoma, Pancreatic Ductal / Q000648:ultrastructure*; D019160:Endosonography; D006801:Humans; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure*; D010190:Pancreatic Neoplasms / Q000648:ultrastructure*