title: FGF21 mediates the lipid metabolism response to amino acid starvation.
abstract: Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The hormone fibroblast growth factor 21 (FGF21), which is critical to the adaptive metabolic response to starvation, is also induced under amino acid deprivation. Upon leucine deprivation, we found that FGF21 is needed to repress expression of lipogenic genes in liver and white adipose tissue, and stimulate phosphorylation of hormone-sensitive lipase in white adipose tissue. The increased expression of Ucp1 in brown adipose tissue under these circumstances is also impaired in FGF21-deficient mice. Our results demonstrate the important role of FGF21 in the regulation of lipid metabolism during amino acid starvation.
authors: Departament de Bioquímica i Biologia Molecular, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain.
authors: Ana Luísa
authors: AL
authors: De Sousa-Coelho
authors: Joana
authors: J
authors: Relat
authors: Elayne
authors: E
authors: Hondares
authors: Albert
authors: A
authors: Pérez-Martí
authors: Francesc
authors: F
authors: Ribas
authors: Francesc
authors: F
authors: Villarroya
authors: Pedro F
authors: PF
authors: Marrero
authors: Diego
authors: D
authors: Haro
mesh_terms: D000596:Amino Acids / Q000172:deficiency* / Q000378:metabolism; D000818:Animals; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D056945:Hep G2 Cells; D006801:Humans; D050356:Lipid Metabolism; D051379:Mice; D018345:Mice, Knockout
chemical_list: D000596:Amino Acids; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors
keywords: brown adipose tissue; fibroblast growth factor 21; leucine deprivation; liver; white adipose tissue
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