title: G34, another connection between MYCN and a pediatric tumor.
abstract: Recurrent mutations in H3F3A at K27 and G34 are frequent in pediatric glioblastoma, but it is unclear how these mutations promote tumorigenesis. In this issue of Cancer Discovery, Bjerke and colleagues identify mutations at G34 in H3F3A that result in elevated expression of MYCN as a potential mechanism in gliomagenesis.
authors: University of California San Francisco, San Francisco, CA, USA.
authors: Miller
authors: M
authors: Huang
authors: William A
authors: WA
authors: Weiss
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D002648:Child; D005909:Glioblastoma / Q000235:genetics*; D006657:Histones / Q000235:genetics*; D006801:Humans; D009154:Mutation; D000071447:N-Myc Proto-Oncogene Protein; D009687:Nuclear Proteins / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics*; D020033:Protein Isoforms / Q000235:genetics
chemical_list: D006657:Histones; C459801:MYCN protein, human; D000071447:N-Myc Proto-Oncogene Protein; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D020033:Protein Isoforms
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