title: Current aspects in the pathophysiology and treatment of chronic wounds in diabetes mellitus.
abstract: Impaired wound healing is a frequent and very severe problem in patients with diabetes mellitus, yet little is known about the underlying pathomechanisms. In this paper we review the biology of wound healing with particular attention to the pathophysiology of chronic wounds in diabetic patients. The standard treatment of diabetic ulcers includes measures to optimize glycemic control as well as extensive debridement, infection elimination by antibiotic therapy based on wound pathogen cultures, the use of moisture dressings, and offloading high pressure from the wound bed. In this paper we discuss novel adjuvant therapies with particular reference to the use of autologous skin transplants for the treatment of diabetic foot ulcers which do not respond to standard care.
authors: Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University Medical Center, 01307 Dresden, Germany.
authors: Elena
authors: E
authors: Tsourdi
authors: Andreas
authors: A
authors: Barthel
authors: Hannes
authors: H
authors: Rietzsch
authors: Andreas
authors: A
authors: Reichel
authors: Stefan R
authors: SR
authors: Bornstein
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000503:physiopathology* / Q000628:therapy*; D017719:Diabetic Foot / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D014945:Wound Healing; D014947:Wounds and Injuries / Q000503:physiopathology* / Q000628:therapy*
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