title: Autophagosome formation: tracing the source.
abstract: Although it is well appreciated that autophagy begins with phagophore formation and expansion through lipid acquisition to become the autophagosome, this process remains poorly understood, with the source of autophagosome membrane controversial. Reporting recently in Nature, Hamasaki et al. (2013) suggest that the ER-mitochondria contact sites are involved in phagophore assembly.
authors: Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
authors: Amélie
authors: A
authors: Bernard
authors: Daniel J
authors: DJ
authors: Klionsky
references: Nat Rev Mol Cell Biol. 2012 Oct;13(10):607-25
references: 22992592
references: J Cell Biol. 2008 Aug 25;182(4):685-701
references: 18725538
references: Nature. 2013 Mar 21;495(7441):389-93
references: 23455425
references: Cell. 2012 Dec 7;151(6):1256-69
references: 23217709
references: F1000 Biol Rep. 2011;3:25
references: 22162728
references: Cell. 2010 May 14;141(4):656-67
references: 20478256
references: Nat Cell Biol. 2009 Dec;11(12):1433-7
references: 19898463