title: Immunosenescence and organ transplantation.
abstract: Increasing numbers of elderly transplant recipients and a growing demand for organs from older donors impose pressing challenges on transplantation medicine. Continuous and complex modifications of the immune system in parallel to aging have a major impact on transplant outcome and organ quality. Both, altered alloimmune responses and increased immunogenicity of organs present risk factors for inferior patient and graft survival. Moreover, a growing body of knowledge on age-dependent modifications of allorecognition and alloimmune responses may require age-adapted immunosuppression and organ allocation. Here, we summarize relevant aspects of immunosenescence and their possible clinical impact on organ transplantation.
authors: Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: Timm
authors: T
authors: Heinbokel
authors: Abdallah
authors: A
authors: Elkhal
authors: Guangxiang
authors: G
authors: Liu
authors: Karoline
authors: K
authors: Edtinger
authors: Stefan G
authors: SG
authors: Tullius
mesh_terms: D000368:Aged; D000375:Aging / Q000276:immunology*; D006084:Graft Rejection / Q000453:epidemiology* / Q000276:immunology*; D006801:Humans; D016377:Organ Transplantation / Q000639:trends*; D012307:Risk Factors; D014181:Transplantation Immunology
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