title: A bioreducible linear poly(β-amino ester) for siRNA delivery.
abstract: Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.
authors: Department of Biomedical Engineering, the Institute for Nanobiotechnology, and the Translational Tissue Engineering Center, The Johns Hopkins University School of Medicine, 400 N. Broadway/Smith Building Room 5017, Baltimore, Maryland 21231, USA.
authors: Kristen L
authors: KL
authors: Kozielski
authors: Stephany Y
authors: SY
authors: Tzeng
authors: Jordan J
authors: JJ
authors: Green
mesh_terms: D045744:Cell Line, Tumor; D049452:Green Fluorescent Proteins / Q000235:genetics; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry / Q000235:genetics
chemical_list: D011108:Polymers; D034741:RNA, Small Interfering; C507253:poly(beta-amino ester); D049452:Green Fluorescent Proteins
references: J Control Release. 2011 Mar 10;150(2):177-86
references: 21130817
references: Parasitol Today. 2000 Aug;16(8):347-9
references: 10900483
references: Biomacromolecules. 2011 Oct 10;12(10):3601-11
references: 21853982
references: Free Radic Biol Med. 1999 Nov;27(9-10):922-35
references: 10569625
references: Int J Nanomedicine. 2011;6:3309-22
references: 22228998
references: Bioconjug Chem. 2008 Feb;19(2):499-506
references: 18205328
references: Adv Healthc Mater. 2013 Mar;2(3):468-80
references: 23184674
references: Biomaterials. 2010 Nov;31(31):8088-96
references: 20674001
references: J Control Release. 2008 Aug 25;130(1):57-63
references: 18599144
references: Nature. 1998 Feb 19;391(6669):806-11
references: 9486653
references: J Control Release. 2011 Apr 10;151(1):35-44
references: 21244853
references: Nano Lett. 2009 Jun;9(6):2402-6
references: 19422265
references: Mol Pharm. 2012 Nov 5;9(11):3375-83
references: 22970908
references: Biomaterials. 2012 Sep;33(27):6495-506
references: 22704597
references: Acc Chem Res. 2012 Jul 17;45(7):1100-12
references: 22129162
references: Acc Chem Res. 2008 Jun;41(6):749-59
references: 18507402
references: Biomaterials. 2012 Nov;33(32):8142-51
references: 22871421
references: Biomaterials. 2011 Aug;32(23):5402-10
references: 21536325