title: Two new cholinesterase inhibitors asiatoates A and B from Buddleja asiatica.
abstract: Two new benzoates, asiatoate A (1) and asiatoate B (2), have been isolated from the ethyl acetate soluble fraction of Buddleja asiatica whole plant. Their structures were elucidated with the help of spectroscopic data. Both showed significant inhibitory effect on acetylcholinesterase (AChE) and butylcholinesterase (BChE) in a dose-dependent manner. The IC50 values of compounds 1-2 were 5.54 and 8.34 μM against AChE while 30.94 and 35.94 μM against BChE, respectively.
authors: Department of Chemistry, Gomal University, Dera Ismail Khan, 27100, KPK, Pakistan.
authors: Farman
authors: F
authors: Ali
authors: Hidayat Ullah
authors: HU
authors: Khan
authors: Masood
authors: M
authors: Afzal
authors: Abdul
authors: A
authors: Samad
authors: Shafi Ullah
authors: SU
authors: Khan
authors: Irshad
authors: I
authors: Ali
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032861:Buddleja / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010154:Pakistan
chemical_list: D001565:Benzoates; D002800:Cholinesterase Inhibitors; C583109:asiatoate A; C583110:asiatoate B; D000110:Acetylcholinesterase