title: Amphiphilic poly(L-aspartic acid) copolymer nanoparticles for cyclosporine A delivery.
abstract: In this paper, novel cyclosporine A (CsA)-loaded amphiphilic poly(L-aspartic acid-co-L-lactic acid) (PAL)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) copolymer nanoparticles (NPs) were successfully fabricated using an emulsion/solvent evaporation technique. The CsA-loaded NPs were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The CsA-loaded NPs size, size distribution, encapsulation efficiency (EE) and drug-loading content (LC) were influenced by polyvinyl alcohol (PVA) concentration and the weight ratio of the copolymer to CsA. In vitro release behavior of CsA-loaded NPs showed a sustained release. With the increasing of copolymer/CsA weight ratio, the release of CsA from NPs is rapid. The poly(L-aspartic acid) derivatives NPs have a promising potential in hydrophobic drug delivery system.
authors: National Center for Nanoscience and Technology, China, Beijing 100190, China.
authors: Siyuan
authors: S
authors: Han
authors: Yun
authors: Y
authors: Sun
authors: Shishuai
authors: S
authors: Su
authors: Liming
authors: L
authors: Hu
authors: Yan
authors: Y
authors: Wu