title: Cytotoxic monacolin analogs from Monascus purpureus-fermented rice.
abstract: Two new monacolin analogs, monacolins O (1) and P (2), along with three known analogs, have been isolated from the ethanolic extract of Monascus purpureus-fermented rice. Their structures and absolute configurations were elucidated by spectroscopic methods, especially 2D NMR and CD spectral analyses as well as chemical method. Both 1 and 2 were tested against five tumor cell lines, and compound 1 exhibited selective cytotoxic activity against A2780 and A549 cell lines, with IC50 values of 3.7 and 8.0 μM, respectively.
authors: Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China.
authors: Ming-Tao
authors: MT
authors: Liu
authors: A-Li
authors: AL
authors: Wang
authors: Zhen
authors: Z
authors: Sun
authors: Jin-Jie
authors: JJ
authors: Li
authors: Xiu-Li
authors: XL
authors: Wu
authors: Yan-Xia
authors: YX
authors: Liu
authors: Xiao-Ya
authors: XY
authors: Shang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005285:Fermentation; D006801:Humans; D015394:Molecular Structure; D032741:Monascus / Q000737:chemistry*; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D012275:Oryza / Q000378:metabolism / Q000382:microbiology*
chemical_list: D000970:Antineoplastic Agents; D009281:Naphthalenes; C583100:monacolin O; C583101:monacolin P