title: Within-host and between-host evolutionary rates across the HIV-1 genome.
abstract: BACKGROUND
  HIV evolves rapidly at the epidemiological level but also at the within-host level. The virus' within-host evolutionary rates have been argued to be much higher than its between-host evolutionary rates. However, this conclusion relies on analyses of a short portion of the virus envelope gene. Here, we study in detail these evolutionary rates across the HIV genome.
  
  
  RESULTS
  We build phylogenies using a relaxed molecular clock assumption to estimate evolutionary rates in different regions of the HIV genome. We find that these rates vary strongly across the genome, with higher rates in the envelope gene (env). Within-host evolutionary rates are consistently higher than between-host rates throughout the HIV genome. This difference is significantly more pronounced in env. Finally, we find weak differences between overlapping and non-overlapping regions.
  
  
  CONCLUSIONS
  We provide a genome-wide overview of the differences in the HIV rates of molecular evolution at the within- and between-host levels. Contrary to hepatitis C virus, where differences are only located in the envelope gene, within-host evolutionary rates are higher than between-host evolutionary rates across the whole HIV genome. This supports the hypothesis that HIV strains that are less adapted to the host have an advantage during transmission. The most likely mechanism for this is storage and then preferential transmission of viruses in latent T-cells. These results shed a new light on the role of the transmission bottleneck in the evolutionary dynamics of HIV.
authors: Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM1, UM2), 911 avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France. samuel.alizon@cnrs.fr
authors: Samuel
authors: S
authors: Alizon
authors: Christophe
authors: C
authors: Fraser
mesh_terms: D019143:Evolution, Molecular; D016679:Genome, Viral; D005838:Genotype; D015658:HIV Infections / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D059645:Mutation Rate; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics
chemical_list: D012367:RNA, Viral
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