title: Fosphenytoin induced transient pendular nystagmus.
abstract: Pendular nystagmus was seen after intravenous infusion of fosphenytoin for the treatment of breakthrough seizure. The oscillations were conjugate, quasi-sinusoidal, and regular. The nystagmus was resolved within 12h. Phenytoin is known to cause conduction slowing. Such delays in the feedback between the cerebellum and the oculomotor neural integrator may cause instability of the integrator. An improvement in the conduction delay following post-ictal recovery may resolve the pendular nystagmus.
authors: Department of Neurology, Case Western Reserve University, Cleveland, OH, USA. aasefshaikh@gmail.com
authors: Aasef G
authors: AG
authors: Shaikh
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009759:Nystagmus, Pathologic / Q000139:chemically induced*; D010349:Patient Compliance; D010672:Phenytoin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012438:Saccades
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin; C043114:fosphenytoin