title: Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats.
abstract: Electrophysiological data suggest a dual role of Y2 receptors (Y2 Rs) as autoreceptors regulating neuropeptide Y release and heteroceptors regulating gamma-aminobutyric acid release in the central amygdala (CeA). Here, we report that neither systemic (JNJ-31020028) nor intra-CeA (BIIE0246) Y2 R antagonism altered operant alcohol responding by alcohol-dependent or non-dependent rats. Conversely, BIIE0246 in the CeA reduced anxiety-like behavior in alcohol-dependent and alcohol-naïve rats. The finding that Y2 R antagonism reduces anxiety-like behavior but not alcohol drinking suggests that these two effects may occur via different functions of the Y2 R (e.g. autoreceptor versus heteroceptor function).
authors: Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.
authors: Marsida
authors: M
authors: Kallupi
authors: Leandro F
authors: LF
authors: Vendruscolo
authors: Casey Y
authors: CY
authors: Carmichael
authors: Olivier
authors: O
authors: George
authors: George F
authors: GF
authors: Koob
authors: Nicholas W
authors: NW
authors: Gilpin
mesh_terms: D000428:Alcohol Drinking / Q000517:prevention & control*; D000437:Alcoholism / Q000517:prevention & control*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001007:Anxiety / Q000517:prevention & control*; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001549:Benzamides / Q000494:pharmacology; D001552:Benzazepines / Q000494:pharmacology; D066274:Central Amygdaloid Nucleus / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D017208:Rats, Wistar; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors*; D012055:Reinforcement Schedule; D012054:Reinforcement, Psychology
chemical_list: D014151:Anti-Anxiety Agents; D001549:Benzamides; D001552:Benzazepines; D002492:Central Nervous System Depressants; C547250:JNJ-31020028; D010879:Piperazines; D017476:Receptors, Neuropeptide Y; C095889:neuropeptide Y2 receptor; D000431:Ethanol; D001120:Arginine; C403256:BIIE 0246
keywords: Alcohol dependence; Y2 receptor; anxiety; negative reinforcement; self-administration; vapor model
references: Am J Physiol. 1997 Oct;273(4):H1737-44
references: 9362238
references: Neurosci Biobehav Rev. 2012 Feb;36(2):873-88
references: 22101113
references: Br J Pharmacol. 1994 Nov;113(3):737-40
references: 7858862
references: Alcohol. 2011 Sep;45(6):567-76
references: 21145691
references: Psychopharmacology (Berl). 2010 Feb;208(2):265-77
references: 19953226
references: Neurosci Lett. 2005 Feb 28;375(2):129-33
references: 15670655
references: Biol Psychiatry. 2011 Jun 1;69(11):1091-9
references: 21459365
references: Neuropsychopharmacology. 1993 Jun;8(4):357-63
references: 8099792
references: Pharmacol Biochem Behav. 2002 Mar;71(3):419-23
references: 11830176
references: J Neurosci. 2010 May 5;30(18):6282-90
references: 20445054