title: Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population.
abstract: OBJECTIVE
  Obstructive sleep apnea (OSA) contributes to the development of systemic hypertension, and hypertension strongly predicts the development of white matter change (WMC). Thus, it is plausible that OSA mediates WMC. The goal of the current study is to determine whether a contextual relationship exists between OSA and cerebral WMC.
  
  
  METHODS
  Cross-sectional analyses conducted in a population-based study.
  
  
  METHODS
  Korean community-based sample from the Korean Genome and Epidemiology Study (KoGES) who attended examinations in 2011 at a medical center.
  
  
  METHODS
  There were 503 individuals (mean ± SD, age 59.63 ± 7.48 y) who were free of previously diagnosed cardiovascular and neurologic diseases.
  
  
  RESULTS
  Participants underwent 1-night polysomnography and were classified as no OSA (obstructive apnea-hypopnea index [AHI] < 5, n = 289), mild OSA (AHI 5-15, n = 161), and moderate to severe OSA (AHI ≥ 15, n = 53). WMC was identified with brain magnetic resonance imaging (MRI) and was found in 199 individuals (39.56%). Multivariate logistic regression analyses adjusted for covariates revealed that moderate to severe OSA was significantly associated with the presence of WMC (odds ratio [OR] 2.08, 95%, confidence interval [CI] 1.05-4.13) compared with no OSA. Additional adjustment of hypertension to the model did not alter the significance of the association (OR 2.03, 95% CI 1.02-4.05).
  
  
  CONCLUSIONS
  Moderate to severe OSA is an independent risk factor for WMC in middle-aged and older individuals. Thus, early recognition and treatment of OSA could reduce the risk of stroke and vascular dementia.
authors: Institute of Human Genomic Study, School of Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.
authors: Hyun
authors: H
authors: Kim
authors: Chang-Ho
authors: CH
authors: Yun
authors: Robert Joseph
authors: RJ
authors: Thomas
authors: Seung Hoon
authors: SH
authors: Lee
authors: Hyung Suk
authors: HS
authors: Seo
authors: Eo Rin
authors: ER
authors: Cho
authors: Seung Ku
authors: SK
authors: Lee
authors: Dae Wui
authors: DW
authors: Yoon
authors: Sooyeon
authors: S
authors: Suh
authors: Chol
authors: C
authors: Shin
mesh_terms: D000367:Age Factors; D000368:Aged; D001921:Brain / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D056910:Republic of Korea; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000473:pathology*
keywords: General population; obstructive sleep apnea; stroke; white matter change
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