title: Upconversion nanophosphors Naluf₄:Yb,Tm for lymphatic imaging in vivo by real-time upconversion luminescence imaging under ambient light and high-resolution X-ray CT.
abstract: Lanthanide upconversion nanophosphor (UCNP) has attracted increasing attention for potential applications in bioimaging due to its excellence in deep and high contrast imaging. To date, most upconversion imaging applications were demonstrated in dark surroundings without ambient light for higher signal-to-noise ratio, which hindered the application of optical imaging guided surgery. Herein, the new established NaLuF₄-based UCNP (NaLuF₄:Yb,Tm, ~17 nm) with bright upconversion emission around 800 nm as imaging signal was used to realize imaging under ambient light to provide more convenient for clinician. Moreover, due to the existance of heavy element lutetium (Lu) in the host lattice, the NaLuF₄:Yb,Tm nanoparticles can also be used as an X-ray CT imaging agent to enhance the imaging depth and in vivo imaging resolution.
authors: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, P.R. China.
authors: Yun
authors: Y
authors: Sun
authors: Juanjuan
authors: J
authors: Peng
authors: Wei
authors: W
authors: Feng
authors: Fuyou
authors: F
authors: Li
mesh_terms: D000818:Animals; D005459:Fluorides / Q000633:toxicity; D007091:Image Processing, Computer-Assisted; D049449:Luminescence; D008187:Lutetium / Q000633:toxicity; D042601:Lymphatic Vessels / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D013050:Spectrometry, Fluorescence; D013932:Thulium; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D015018:Ytterbium
chemical_list: D008187:Lutetium; D013932:Thulium; D015018:Ytterbium; D005459:Fluorides
keywords: Lanthanide; bioimaging; computed tomography; lutetium; upconversion luminescence
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