title: A double signal amplification platform for ultrasensitive and simultaneous detection of ascorbic acid, dopamine, uric acid and acetaminophen based on a nanocomposite of ferrocene thiolate stabilized Fe₃O₄@Au nanoparticles with graphene sheet.
abstract: A double signal amplification platform for ultrasensitive and simultaneous detection of ascorbic acid (AA), dopamine (DA), uric acid (UA) and acetaminophen (AC) was fabricated by a nanocomposite of ferrocene thiolate stabilized Fe₃O₄@Au nanoparticles with graphene sheet. The platform was constructed by coating a newly synthesized phenylethynyl ferrocene thiolate (Fc-SAc) modified Fe₃O₄@Au NPs coupling with graphene sheet/chitosan (GS-chitosan) on a glassy carbon electrode (GCE) surface. The Fe₃O₄@Au-S-Fc/GS-chitosan modified GCE exhibits a synergistic catalytic and amplification effect toward AA, DA, UA and AC oxidation. The oxidation peak currents of the four compounds on the electrode were linearly dependent on AA, DA, UA and AC concentrations in the ranges of 4-400 μM, 0.5-50 μM, 1-300 μM and 0.3-250 μM in the individual detection of each component, respectively. By simultaneously changing the concentrations of AA, DA, UA and AC, their electrochemical oxidation peaks appeared at -0.03, 0.15, 0.24 and 0.35 V, and good linear current responses were obtained in the concentration ranges of 6-350, 0.5-50, 1-90 and 0.4-32 μM with the detection limits of 1, 0.1, 0.2 and 0.05 μM (S/N=3), respectively.
authors: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, China, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.
authors: Meiling
authors: M
authors: Liu
authors: Qiong
authors: Q
authors: Chen
authors: Cailang
authors: C
authors: Lai
authors: Youyu
authors: Y
authors: Zhang
authors: Jianhui
authors: J
authors: Deng
authors: Haitao
authors: H
authors: Li
authors: Shouzhuo
authors: S
authors: Yao
mesh_terms: D000082:Acetaminophen / Q000032:analysis* / Q000097:blood / Q000652:urine; D001205:Ascorbic Acid / Q000032:analysis* / Q000097:blood / Q000652:urine; D015374:Biosensing Techniques / Q000379:methods; D004298:Dopamine / Q000032:analysis* / Q000097:blood / Q000652:urine; D055664:Electrochemical Techniques / Q000379:methods; D052203:Ferrosoferric Oxide / Q000737:chemistry; D005296:Ferrous Compounds / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D006108:Graphite / Q000737:chemistry; D006801:Humans; D057230:Limit of Detection; D000075163:Metallocenes; D053761:Nanocomposites / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D014527:Uric Acid / Q000032:analysis* / Q000097:blood / Q000652:urine
chemical_list: D005296:Ferrous Compounds; D000075163:Metallocenes; D013438:Sulfhydryl Compounds; D014527:Uric Acid; D000082:Acetaminophen; D006046:Gold; D006108:Graphite; D001205:Ascorbic Acid; C004998:ferrocene; D004298:Dopamine; D052203:Ferrosoferric Oxide