title: Correlation between aerial insecticide spraying to interrupt west nile virus transmission and emergency department visits in Sacramento County, California.
abstract: OBJECTIVE
  Insecticides reduce vector-borne pathogen transmission but also pose health risks. In August 2005, Sacramento County, California, underwent emergency aerial ultralow-volume (ULV) application of pyrethrin insecticide to reduce the population of West Nile virus (WNV)-infected mosquitoes and thereby interrupt enzootic and tangential transmission. We assessed the association between aerially applied pyrethrin insecticide and patterns of emergency department (ED) visit diagnoses.
  
  
  METHODS
  We used geographic information systems software to determine ZIP Code-level exposure to pyrethrin. We used logistic regression models to examine the relationship between exposure status and three-digit International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9-CM) codes (785 in total) for all ED visits (n=253,648) within Sacramento County in 2005 and for specific diagnostic clusters (e.g., respiratory, gastrointestinal, skin, eye, and neurologic). All models were adjusted for age, gender, race/ethnicity (individual level), median income, ozone, and temperature (ZIP Code level).
  
  
  RESULTS
  Exposure to aerially applied insecticide was not associated with clusters of respiratory, gastrointestinal, skin, eye, and neurologic complaints in adjusted models but was inversely associated with ICD-9-CM code 799 ("other ill-defined morbidity and mortality"), with adjusted odds ratios (AORs) ranging from 0.31 to 0.36 for 0-3 lag days (95% confidence interval 0.17, 0.68). Spraying was also directly associated with ICD-9-CM code 553 ("other abdominal hernia"), with AORs ranging from 2.34 to 2.96 for 2-3 lag days.
  
  
  CONCLUSIONS
  The observed significant ICD-9-CM code associations likely represented chance findings. Aerial ULV pyrethrin applications were not associated with ED visits for specific diagnoses or clusters of diagnoses.
authors: University of California, Davis, Division of General Medicine, Sacramento, CA 95817, USA. estella.geraghty@ucdmc.ucdavis.edu
authors: Estella M
authors: EM
authors: Geraghty
authors: Helene G
authors: HG
authors: Margolis
authors: Anne
authors: A
authors: Kjemtrup
authors: William
authors: W
authors: Reisen
authors: Peter
authors: P
authors: Franks
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002140:California; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D004781:Environmental Exposure; D005260:Female; D040362:Geographic Information Systems; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D007306:Insecticides / Q000008:administration & dosage*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009032:Mosquito Control / Q000379:methods; D011722:Pyrethrins / Q000008:administration & dosage*; D014901:West Nile Fever / Q000175:diagnosis / Q000635:transmission*; D014902:West Nile virus / Q000187:drug effects*; D055815:Young Adult
chemical_list: D007306:Insecticides; D011722:Pyrethrins
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