title: Cytological diagnosis of Langerhans cell histiocytosis with cutaneous involvement.
abstract: Langerhans cell histiocytosis (LCH) is a rare disease affecting predominantly children. The course of the disease varies, from spontaneous resolution to a progressive multisystem disorder with organ dysfunction and potential life-threatening complications. Diagnosis of LCH is often difficult and may be delayed because of its rarity and especially so if it occurs with unusual presentation. Fine needle aspiration cytology of a 4 year old male child, a case of LCH is presented with a purpose of highlighting the characteristic cytological features. A high index of suspicion, awareness of characteristic cytological features of LCH and its differential diagnoses is necessary. This can obviate the need of biopsy and electron microscopy. Immunohistochemistry if available can be performed on cytology smear and cell block.
authors: Department of Pathology, Topiwala National Medical College and B. Y. L. Nair Charitable Hospital, Mumbai, Maharashtra, India.
authors: Sushama A
authors: SA
authors: Chandekar
authors: Vinaya B
authors: VB
authors: Shah
authors: Vikas
authors: V
authors: Kavishwar
keywords: CD1a; Langerhans cell histiocytosis; nuclear grooves
references: Head Neck Pathol. 2010 Dec;4(4):343-6
references: 21088940
references: Dis Model Mech. 2009 Sep-Oct;2(9-10):436-9
references: 19726802
references: J Bone Joint Surg Am. 1980 Dec;62(8):1284-90
references: 6254994
references: World J Pediatr. 2010 Aug;6(3):255-9
references: 20549416
references: An Bras Dermatol. 2009 Jul-Aug;84(4):405-9
references: 19851674
references: Indian Pediatr. 2008 Aug;45(8):685-8
references: 18723913
references: Patholog Res Int. 2011 Jan 20;2011:439518
references: 21331166
references: Korean J Hematol. 2011 Sep;46(3):186-91
references: 22065974
references: Acta Derm Venereol. 2009;89(3):299-301
references: 19479131