title: Neuromagnetic evidence of abnormal movement-related beta desynchronization in Parkinson's disease.
abstract: Parkinson's disease (PD) is a neurodegenerative disorder associated with debilitating motor, posture, and gait abnormalities. Human studies recording local field potentials within the subthalamic nucleus and scalp-based electroencephalography have shown pathological beta synchronization throughout the cortical-basal ganglia motor network in PD. Suppression of such pathological beta synchronization has been associated with improved motor function, which may explain the effectiveness of deep-brain stimulation. We used magnetoencephalography (MEG) to investigate neural population-level beta responses, and other oscillatory activity, during a motor task in unmedicated patients with PD and a matched group of healthy adults. MEG is a noninvasive neurophysiological technique that permits the recording of oscillatory activity during movement planning, execution, and termination phases. Each of these phases was independently examined using beamforming to distinguish the brain areas and movement phases, where pathological oscillations exist during motor control. Patients with PD exhibited significantly diminished beta desynchronization compared with controls prior to and during movement, which paralleled reduced alpha desynchronization. This study is the first to systematically investigate neural oscillatory responses in PD during distinct stages of motor control (e.g. planning, execution, and termination) and indicates that these patients have significant difficulty suppressing cortical beta synchronization during movement planning, which may contribute to their diminished movement capacities.
authors: Department of Psychology, University of Nebraska, Omaha, NE, USA, Center for Magnetoencephalography.
authors: Elizabeth
authors: E
authors: Heinrichs-Graham
authors: Department of Pharmacology and Experimental Neuroscience, Department of Neurological Sciences, Center for Magnetoencephalography.
authors: Tony W
authors: TW
authors: Wilson
authors: Department of Neurology, Neurology Consultants of Nebraska, Omaha, NE, USA.
authors: Pamela M
authors: PM
authors: Santamaria
authors: Department of Neurological Sciences.
authors: Sheila K
authors: SK
authors: Heithoff
authors: Department of Neurological Sciences.
authors: Diego
authors: D
authors: Torres-Russotto
authors: Department of Pharmacology and Experimental Neuroscience.
authors: Jessica A L
authors: JA
authors: Hutter-Saunders
authors: Department of Pharmacology and Experimental Neuroscience.
authors: Katherine A
authors: KA
authors: Estes
authors: Department of Biostatistics, University of Nebraska Medical Center (UNMC), Omaha, NE, USA and.
authors: Jane L
authors: JL
authors: Meza
authors: Department of Pharmacology and Experimental Neuroscience.
authors: R L
authors: RL
authors: Mosley
authors: Department of Pharmacology and Experimental Neuroscience.
authors: Howard E
authors: HE
authors: Gendelman
mesh_terms: D000368:Aged; D001611:Beta Rhythm; D003344:Cortical Synchronization / Q000502:physiology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology*
keywords: MEG; cortex; magnetoencephalography; motor control; oscillations
references: Neurosci Lett. 2001 Oct 26;312(3):149-52
references: 11602332
references: Clin Neurophysiol. 2005 Aug;116(8):1879-88
references: 15979401
references: Brain. 2004 Apr;127(Pt 4):735-46
references: 14960502
references: Neuroimage. 2011 Mar 15;55(2):616-21
references: 21215806
references: Neurology. 1998 May;50(5):1346-50
references: 9595985
references: Brain. 1997 Jan;120 ( Pt 1):103-10
references: 9055801
references: Neuroimage. 2005 Apr 15;25(3):734-45
references: 15808975
references: Neuroreport. 2001 Dec 4;12(17):3859-63
references: 11726809
references: Neurobiol Aging. 2013 Feb;34(2):408-18
references: 22495052
references: Hum Brain Mapp. 2005 Jun;25(2):199-211
references: 15846771
references: Phys Med Biol. 2006 Apr 7;51(7):1759-68
references: 16552102
references: Neuroimage. 1995 Dec;2(4):237-43
references: 9343608
references: Electroencephalogr Clin Neurophysiol. 1996 Apr;98(4):281-93
references: 8641150
references: Electroencephalogr Clin Neurophysiol. 1992 Jul;83(1):62-9
references: 1376667
references: Clin Neurophysiol. 2006 Mar;117(3):628-36
references: 16427358
references: J Neural Transm (Vienna). 2009 Feb;116(2):193-202
references: 18982241
references: J Neurosci. 2010 Aug 25;30(34):11270-7
references: 20739547
references: Brain. 2000 Feb;123 ( Pt 2):394-403
references: 10648446
references: Int J Psychophysiol. 1997 Jun;26(1-3):121-35
references: 9202999
references: J Neurosci. 2008 Jun 11;28(24):6165-73
references: 18550758
references: J Neurophysiol. 2010 Nov;104(5):2873-85
references: 20884762
references: J Neurol Neurosurg Psychiatry. 1994 May;57(5):567-71
references: 8201325
references: Neuroimage. 2010 Jun;51(2):792-807
references: 20116434
references: IEEE Trans Biomed Eng. 1997 Sep;44(9):867-80
references: 9282479
references: Med Biol Eng Comput. 1997 Mar;35(2):135-40
references: 9136207
references: Mov Disord. 2012 Jun;27(7):864-73
references: 22648508
references: Brain. 2002 Mar;125(Pt 3):491-500
references: 11872607
references: Brain Cogn. 2010 Jul;73(2):75-84
references: 20418003
references: Science. 2009 Apr 17;324(5925):354-9
references: 19299587
references: Neuroimage. 2008 Aug 1;42(1):332-42
references: 18511304
references: J Neural Transm (Vienna). 2010 Apr;117(4):489-98
references: 20217436
references: Neuroepidemiology. 2010;34(3):143-51
references: 20090375
references: Brain Topogr. 2004 Summer;16(4):233-8
references: 15379219
references: Brain. 1997 Jan;120 ( Pt 1):141-57
references: 9055804
references: Brain. 2007 Jul;130(Pt 7):1847-60
references: 17412733
references: Neurosci Lett. 2004 Aug 5;366(1):18-23
references: 15265582
references: J Neurol Neurosurg Psychiatry. 2008 Apr;79(4):368-76
references: 18344392
references: Am J Ind Med. 2010 Mar;53(3):217-23
references: 20025075
references: Occup Environ Med. 2007 Oct;64(10):666-72
references: 17332139
references: Clin Neurophysiol. 2009 May;120(5):910-5
references: 19386543
references: Neuroimage. 2006 Sep;32(3):1281-9
references: 16863693
references: Clin Neurophysiol. 1999 Nov;110(11):1842-57
references: 10576479
references: Arch Neurol. 2005 Jan;62(1):91-5
references: 15642854
references: J Neurosci Methods. 2007 Aug 15;164(1):177-90
references: 17517438
references: Brain. 2002 Jun;125(Pt 6):1235-46
references: 12023312
references: Physiol Rev. 2011 Oct;91(4):1161-218
references: 22013209
references: Clin Neurophysiol. 2006 Nov;117(11):2521-31
references: 16997626
references: J Neurophysiol. 2011 Mar;105(3):1112-21
references: 21177996
references: Parkinsonism Relat Disord. 2007;13 Suppl 3:S440-5
references: 18267280
references: Cereb Cortex. 2009 May;19(5):1055-63
references: 18787234
references: J Neurophysiol. 2009 Aug;102(2):1241-53
references: 19515947
references: J Neurophysiol. 2007 Dec;98(6):3525-37
references: 17928554
references: Curr Opin Neurobiol. 2007 Dec;17(6):656-64
references: 18221864
references: J Neurophysiol. 2006 Dec;96(6):3248-56
references: 17005611
references: Trends Neurosci. 2007 Jul;30(7):357-64
references: 17532060
references: Neuroimage. 2011 Feb 14;54(4):2983-93
references: 21112405
references: Neuroimage. 2006 Feb 1;29(3):685-96
references: 16242346
references: Dev Neuropsychol. 2011;36(5):596-613
references: 21667363
references: Brain. 2003 Feb;126(Pt 2):451-61
references: 12538411
references: Biomed Sci Instrum. 1977 Apr 25-27;13:135-45
references: 871500
references: J Neurol Neurosurg Psychiatry. 2002 Nov;73(5):529-34
references: 12397145
references: Nat Neurosci. 2000 Dec;3(12):1301-6
references: 11100151
references: Neuroimage. 2008 Jun;41(2):212-22
references: 18395468