title: MMP-2 -1306C>T polymorphism in breast cancer: a case-control study in a South European population.
abstract: This case control study aims to investigate the role of MMP-2 -1306C>T polymorphism as a potential risk factor and possible prognostic marker for breast cancer in a South European population. 113 consecutive incident cases of histologically confirmed ductal breast cancer and 124 healthy controls were recruited. MMP-2 -1306C>T polymorphism was genotyped; multivariate logistic regression as well as Cox regression analysis were performed. MMP-2 -1306C>T status was not associated with breast cancer risk either at the total sample or at the subanalyses on premenopausal and postmenopausal women. At the survival analysis, a trend towards a favorable association between MMP-2 -1306C>T allele and disease-free survival as well as overall survival was observed. Regarding subanalyses on ER-negative and ER-positive cases, the favorable association implicating MMP-2 -1306C>T allele was particularly evident among ER-positive cases; no significant associations emerged among ER-negative cases. MMP-2 -1306C>T polymorphism does not seem to be a risk factor for breast cancer in South European population; however, a trend towards a favorable association with survival has been observed.
authors: Department of Clinical Therapeutics, Alexandra Hospital, Medical School, University of Athens, Vas Sofias Ave & Lourou str, 11521, Athens, Greece. florazagouri@yahoo.co.uk
authors: Flora
authors: F
authors: Zagouri
authors: Theodoros N
authors: TN
authors: Sergentanis
authors: Maria
authors: M
authors: Gazouli
authors: Constantine
authors: C
authors: Dimitrakakis
authors: Alexandra
authors: A
authors: Tsigginou
authors: Irene
authors: I
authors: Papaspyrou
authors: Dimosthenis
authors: D
authors: Chrysikos
authors: Maria
authors: M
authors: Lymperi
authors: George C
authors: GC
authors: Zografos
authors: Aris
authors: A
authors: Antsaklis
authors: Meletios-Athanassios
authors: MA
authors: Dimopoulos
authors: Christos A
authors: CA
authors: Papadimitriou
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006115:Greece; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D005819:Genetic Markers; D020778:Matrix Metalloproteinase 2
references: Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1770-6
references: 19454611
references: Mol Biol Rep. 2012 Jun;39(6):6881-6
references: 22307791
references: Carcinogenesis. 2004 Mar;25(3):399-404
references: 14604886
references: Breast Cancer Res Treat. 2007 Mar;102(1):123-4
references: 17260100
references: Mol Biol Rep. 2012 Dec;39(12):10873-9
references: 23065205
references: Clin Chim Acta. 2011 Mar 18;412(7-8):537-40
references: 21130755
references: J Biol Chem. 2001 Mar 9;276(10):7549-58
references: 11114309
references: Breast Cancer Res. 2000;2(4):252-7
references: 11250717
references: Gynecol Obstet Invest. 2008;65(1):68-72
references: 17851253
references: J Biol Chem. 1999 Jul 30;274(31):21491-4
references: 10419448
references: Breast Cancer Res Treat. 2007 May;103(1):61-9
references: 17033924
references: Mol Biol Rep. 2012 Dec;39(12):10859-63
references: 23065203
references: Cancer Res. 2004 Oct 15;64(20):7622-8
references: 15492291
references: Virchows Arch. 1999 Dec;435(6):566-73
references: 10628798
references: Semin Cancer Biol. 2000 Dec;10(6):415-33
references: 11170864
references: Mol Biol Rep. 2012 Jun;39(6):6801-9
references: 22322559
references: Dermatology. 2002;204(4):262-5
references: 12077518
references: Breast Cancer Res Treat. 2004 Dec;88(3):197-204
references: 15609121
references: Mol Pathol. 2002 Oct;55(5):300-4
references: 12354933