title: Real-time handheld multispectral optoacoustic imaging.
abstract: Multispectral optoacoustic tomography (MSOT) of functional and molecular contrast has the potential to find broad deployment in clinical practice. We have developed the first handheld MSOT imaging device with fast wavelength tuning achieving a frame rate of 50 Hz. In this Letter, we demonstrate its clinical potential by dynamically resolving multiple disease-relevant tissue chromophores, including oxy-/deoxyhemoglobin, and melanin, in human volunteers.
authors: Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg 85764, Germany. andreas.buehler@helmholtz‑muenchen.de
authors: Andreas
authors: A
authors: Buehler
authors: Marcin
authors: M
authors: Kacprowicz
authors: Adrian
authors: A
authors: Taruttis
authors: Vasilis
authors: V
authors: Ntziachristos
mesh_terms: D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007259:Infrared Rays; D010108:Oxyhemoglobins / Q000378:metabolism; D061088:Photoacoustic Techniques / Q000295:instrumentation*; D013997:Time Factors; D041622:Tomography, Optical / Q000295:instrumentation*; D014953:Wrist / Q000098:blood supply
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin