title: Carcinoma of the thyroid with ewing family tumor elements and favorable prognosis: report of a second case.
abstract: The rare reports of primary, nonneuroendocrine small cell carcinomas of the thyroid have not provided enough evidence to support the recognition of these tumors as an entity or to understand their etiopathogenesis. We report the second case of a primary, nonneuroendocrine small cell carcinoma of the thyroid displaying diffuse expression of cytokeratins, CD99, and p63, in the absence of vimentin expression, in a 24-year-old male who is alive without any signs of disease 13 years after total thyroidectomy and radioactive iodine. The tumor disclosed the EWSR1-FLI1 rearrangement, and we propose to designate it as a carcinoma of the thyroid with Ewing family tumor elements.
authors: 1Centro Hospitalar de São João, Porto, Portugal.
authors: Catarina
authors: C
authors: Eloy
authors: Mário
authors: M
authors: Oliveira
authors: Joana
authors: J
authors: Vieira
authors: Manuel R
authors: MR
authors: Teixeira
authors: João
authors: J
authors: Cruz
authors: Manuel
authors: M
authors: Sobrinho-Simões
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C576197:EWSR1-FLI1 fusion protein, human; D015514:Oncogene Proteins, Fusion
keywords: CD99; EWSR-FLI1; small cell tumor; thyroid; thyroid carcinoma