title: eXclusion: toward integrating the X chromosome in genome-wide association analyses.
abstract: The X chromosome lags behind autosomal chromosomes in genome-wide association study (GWAS) findings. Indeed, the X chromosome is commonly excluded from GWAS analyses despite being assayed on all current GWAS microarray platforms. This raises the question: why are so few hits reported on the X chromosome? This commentary aims to examine this question through review of the current X chromosome results in the National Human Genome Research Institute Catalog of Published Genome-Wide Association Studies (NHGRI GWAS Catalog). It will also investigate commonly cited reasons for exclusion of the X chromosome from GWAS and review the tools currently available for X chromosome analysis. It will conclude with recommendations for incorporating X chromosome analyses in future studies.
authors: National Human Genome Research Institute (NHGRI), Bethesda, MD, USA. anastasia.wise@nih.gov
authors: Anastasia L
authors: AL
authors: Wise
authors: Lin
authors: L
authors: Gyi
authors: Teri A
authors: TA
authors: Manolio
mesh_terms: D041321:Chromosomes, Human, X / Q000235:genetics*; D030541:Databases, Genetic; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D014481:United States
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