title: Assesment life quality of familial Mediterranean fever patients by short form-36 and its relationship with disease parameters.
abstract: BACKGROUND
  Familial Mediterranean fever is an auto-inflammatory disorder. Long term complications of the disease include decreased quality of life. The measurement of quality of life in the patients with chronic disease has become an important research topic during the last years.
  
  
  OBJECTIVE
  We aimed to evaluate life quality of the FMF patients by SF-36, and examine its relationship with the disease parameters.
  
  
  METHODS
  One hundred voluntary patients (69 female, 31 male) admitted to the rheumatology clinic were included in the study. The control group consisted of 100 healthy individuals. All subjects in the study were asked to complete SF-36 questionnaire. Age of onset of FMF, age at diagnosis, age at the beginning of colchicine therapy, number of attacks per month, family history of FMF and dialysis were inquired of patients with FMF. Disease severity was determined using the FMF severity score.
  
  
  RESULTS
  The mean age of the patient group was 31±12 and that of the control group was 29±9. Sixty-nine patients (69%) were female, and 31 patients were male (31%) in both groups. The mean scores of the physical function, physical role function, emotional role function, mental health, and general health parameters of the patients were statistically significantly lower than those of healthy volunteers (p < 0.05). The difference in social function and vitality between two groups was found to be insignificant (p > 0.05).
  
  
  CONCLUSIONS
  We have shown that FMF had a negative impact on SF-36. FMF reduces quality of life both in physical and mental dimensions.
authors: Department of Internal Medicine, Faculty of Medicine, Gazi Osmanpasa University, Tokat, Turkey. drsafaksahin@gmail.com
authors: S
authors: S
authors: Sahin
authors: I
authors: I
authors: Yalcin
authors: S
authors: S
authors: Senel
authors: H
authors: H
authors: Ataseven
authors: Au
authors: A
authors: Uslu
authors: O
authors: O
authors: Yildirim
authors: M
authors: M
authors: Semiz
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003078:Colchicine / Q000627:therapeutic use; D003598:Cytoskeletal Proteins / Q000235:genetics; D010505:Familial Mediterranean Fever / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D000071198:Pyrin; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin; D003078:Colchicine