title: Brain-derived neurotrophic factor and ciliary neurotrophic factor in maternal plasma and umbilical cord blood from pre-eclamptic and physiological pregnancies.
abstract: The aim of the study was to investigate the circulating levels of ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) in maternal serum and umbilical cord blood from respective pregnancies in pre-eclampsia (PE) cases and a control cohort. A total of 12 pre-eclampsia cases and 34 healthy controls were enrolled and the maternal peripheral blood - umbilical cord blood duos, were examined for BDNF and CNTF levels. BNDF levels were significantly higher in umbilical cord blood from pre-eclamptic pregnancies; there was also significant difference between maternal plasma and umbilical cord blood levels of BDNF (p < 0.001) in the controls. The CNTF levels in umbilical cord blood (CNTF-UCB) were significantly higher in PE cases than in the controls (p = 0.03). Significant differences were observed in expression of BDNF and CNTF proteins in maternal peripheral blood and umbilical cord blood between pre-eclampsia cases and healthy controls.
authors: Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. jbienert@med.muni.cz
authors: J
authors: J
authors: Bienertova-Vasku
authors: P
authors: P
authors: Bienert
authors: F
authors: F
authors: Zlamal
authors: Z
authors: Z
authors: Splichal
authors: J
authors: J
authors: Tomandl
authors: M
authors: M
authors: Tomandlova
authors: Z
authors: Z
authors: Hodicka
authors: P
authors: P
authors: Ventruba
authors: A
authors: A
authors: Vasku
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D016022:Case-Control Studies; D020934:Ciliary Neurotrophic Factor / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005865:Gestational Age; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D020934:Ciliary Neurotrophic Factor; C579455:BDNF protein, human