title: Serum amyloid A as a prognostic marker in cats with various diseases.
abstract: Serum amyloid A (SAA) is reported not only as a marker for the presence of inflammation but also as a prognostic indicator in human beings. In cats, however, there is no report on the association between SAA concentration and prognosis. The objective of the current study was to evaluate SAA concentration as a prognostic marker in diseased cats. A total of 175 cats with neoplastic diseases, inflammatory diseases, and other diseases were retrospectively recruited, and the medical records of these cats, including follow-up data on mortality, were reviewed. Cats were divided into 2 groups according to SAA concentration, and differences in survival between each group were assessed. Median survival time of cats in the elevated SAA (>0.82 mg/l) group was significantly shorter than that in the nonelevated SAA (≤0.82 mg/l) group (P < 0.001). Furthermore, by multivariate analysis, SAA concentration was shown as a significant and independent prognostic marker in cats with various diseases (P = 0.015). Serum amyloid A concentration in diseased cats is a useful predictive indicator of prognosis regardless of diagnosis.
authors: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors: Takashi
authors: T
authors: Tamamoto
authors: Koichi
authors: K
authors: Ohno
authors: Masashi
authors: M
authors: Takahashi
authors: Ko
authors: K
authors: Nakashima
authors: Yasuhito
authors: Y
authors: Fujino
authors: Hajime
authors: H
authors: Tsujimoto
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002371:Cat Diseases / Q000097:blood*; D002415:Cats; D005260:Female; D007249:Inflammation / Q000097:blood / Q000662:veterinary; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000662:veterinary; D012189:Retrospective Studies; D000685:Serum Amyloid A Protein / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D000685:Serum Amyloid A Protein
keywords: Cats; prognostic marker; serum amyloid A