title: Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells.
abstract: Altered cytokine profiles and imbalanced frequencies of CD4(+) T helper cell subsets are thought to be linked with HIV-1/AIDS pathogenesis, but the causes need to be further clarified. Histamine, a biogenic amine with many functions, shows enhancement in HIV-1 infected individuals, which are considered to link with disease progression, but is poorly understood. This study investigated histamine-assisted HIV-1 modulation of dendritic cell (DC) functions. Histamine and HIV-1 showed a synergistic role in induction of interleukin-10; histamine inhibited HIV-1-induced IL-12 production from MDDCs (monocyte-derived DCs); notably, histamine augmented HIV-1-induced MDDC functional polarization and skewed naïve T cell differentiation toward regulatory T cells (Tregs). The results indicate the novel role of histamine in HIV-1-induced DC functional regulation, which promoted Treg cell differentiation and up-regulated immunosuppressive factors. These findings help to bridge the correlation between elevated histamine and increased Treg cell frequency in HIV-1 infected individuals, and add to our understanding of HIV-1-induced immunosuppression.
authors: Research Division of Clinical Pharmacology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors: Rong-Rong
authors: RR
authors: Zhai
authors: Ai-Ping
authors: AP
authors: Jiang
authors: Hai-Bo
authors: HB
authors: Wang
authors: Li
authors: L
authors: Ma
authors: Xiao-Xin
authors: XX
authors: Ren
authors: Jin-Feng
authors: JF
authors: Jiang
authors: Li
authors: L
authors: Wu
authors: Ji-Fu
authors: JF
authors: Wei
authors: Jian-Hua
authors: JH
authors: Wang
mesh_terms: D002478:Cells, Cultured; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006632:Histamine / Q000378:metabolism*; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism*; D016753:Interleukin-10 / Q000378:metabolism; D018664:Interleukin-12 / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D007155:Immunologic Factors; D016753:Interleukin-10; D018664:Interleukin-12; D006632:Histamine