title: Lewis acid-catalyzed cyclization of enaminones with propargylic alcohols: regioselective synthesis of multisubstituted 1,2-dihydropyridines.
abstract: A highly efficient BF3·Et2O-catalyzed cascade reaction of enaminones with propargylic alcohols under mild reaction conditions has been developed. This methodology offers regioselective access to multisubstituted 1,2-dihydropyridines in good to excellent yields.
authors: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, People's Republic of China.
authors: Yushang
authors: Y
authors: Shao
authors: Kai
authors: K
authors: Zhu
authors: Zhengchen
authors: Z
authors: Qin
authors: Ende
authors: E
authors: Li
authors: Yanzhong
authors: Y
authors: Li
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry; D058116:Lewis Acids / Q000737:chemistry*; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D000588:Amines; D004095:Dihydropyridines; D058116:Lewis Acids; D020005:Propanols; C028255:propargyl alcohol