title: Shortened blood coagulation times in genetically obese rats and diet-induced obese mice.
abstract: The aim of this study was to investigate blood coagulation times in genetically obese rats and diet-induced obese (DIO) mice in order to clarify the relationship between visceral obesity and blood coagulation. WBN/Kob-Lepr(fa) (fa/fa) rats, a genetically obese model, exhibited a significantly shorter activated partial thromboplastin time (aPTT) and prothrombin time (PT) than age-matched Wistar rats. C57BL/6J mice fed a high-fat diet (60%), a DIO model, exhibited significantly shorter aPTT, PT and thrombin time than lean mice fed a standard diet. Higher body weight, visceral fat weight and insulin resistance were also shared by fa/fa rats and DIO mice. These results suggest that visceral obesity is related to accelerated blood coagulation in addition to disrupted metabolism of glucose and lipids.
authors: Department of Pharmacology, Azabu University School of Veterinary Medicine, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
authors: Noriyuki
authors: N
authors: Kaji
authors: Dai
authors: D
authors: Nagakubo
authors: Shin-Ichi
authors: S
authors: Hashida
authors: Saya
authors: S
authors: Takahashi
authors: Motoi
authors: M
authors: Kuratani
authors: Norihiko
authors: N
authors: Hirai
authors: Mitsuyuki
authors: M
authors: Shirai
authors: Fumitoshi
authors: F
authors: Asai
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D056128:Obesity, Abdominal / Q000209:etiology / Q000503:physiopathology*; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose