title: Molecular profiling of sinonasal undifferentiated carcinoma.
abstract: BACKGROUND
  Sinonasal undifferentiated carcinoma (SNUC) remains a poorly characterized malignancy at both the clinical and molecular level, and, consequently, the optimal treatment strategy remains undefined.
  
  
  METHODS
  We used a mass spectroscopy-based approach (Sequenom) to evaluate 95 hallmark single nucleotide variations (SNVs) within 12 oncogenes or tumor suppressor genes (AKT, BRAF, CDK4, Beta-catenin, epidermal growth factor receptor [EGFR], FBXW7, JAK2, c-KIT, KRAS, PDGFR, PI3K, and vascular endothelial growth factor [VEGF]) in 13 histologically confirmed SNUC cases.
  
  
  RESULTS
  None of the samples demonstrated activating mutations in any of the 95 SNVs.
  
  
  CONCLUSIONS
  Select clinically relevant activating genomic mutations were not identified in the 13 patient samples. However, polymorphisms were noted within the promoter region of VEGF. These may merit future studies as predictive biomarkers for treatment response or overall survival. Additionally, future studies focusing on larger tumor sets and utilizing whole genome or exome sequencing may help define genetic aberrations in SNUC that can be clinically targeted with available or emerging biological agents.
authors: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas; Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery Baylor College of Medicine, Houston, Texas.
authors: Alexander
authors: A
authors: Gelbard
authors: Katherine S
authors: KS
authors: Hale
authors: Yoko
authors: Y
authors: Takahashi
authors: Michael
authors: M
authors: Davies
authors: Michael E
authors: ME
authors: Kupferman
authors: Adel K
authors: AK
authors: El-Naggar
authors: Jeffrey N
authors: JN
authors: Myers
authors: Ehab Y
authors: EY
authors: Hanna
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D013058:Mass Spectrometry; D008444:Maxillary Sinus Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis
chemical_list: D004273:DNA, Neoplasm
keywords: Sequenom; paranasal sinus tumors; sinonasal undifferentiated carcinoma (SNUC); vascular endothelial growth factor (VEGF)
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