title: Is oxytocin a therapeutic factor for ischemic heart disease?
abstract: Ischemic heart disease (IHD) is among the most important and top ranked causes of death in the world, and its preventive and interventional mechanisms are actively being investigated. Preconditioning may still be beneficial in some situations such as IHD. Development of cardioprotective agents to improve myocardial function, to decrease the incidence of arrhythmias, to delay the onset of necrosis, and to limit the total extent of infarction during IHD is of great clinical importance. In order to reduce morbidity, a new treatment modality must be developed, and oxytocin may indeed be one of the candidates. There is increasing experimental evidence indicating that oxytocin may have cardioprotective effects either by decreasing the extent of reperfusion injury or by pharmacologic preconditioning activity. This review shows that in the presence of oxytocin, the cardioprotective effects may be increased to some extent. The presented board of evidence focuses on the valuable effects of oxytocin on myocardial function and candidates it for future clinical studies in the realm of ischemic heart diseases.
authors: Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran. aalizadeh@razi.tums.ac.ir
authors: Ali Mohammad
authors: AM
authors: Alizadeh
authors: Parasto
authors: P
authors: Mirzabeglo
mesh_terms: D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D003324:Coronary Artery Disease / Q000517:prevention & control; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D009206:Myocardium / Q000473:pathology; D009336:Necrosis / Q000517:prevention & control; D010121:Oxytocin / Q000502:physiology* / Q000627:therapeutic use
chemical_list: D002316:Cardiotonic Agents; D010121:Oxytocin