title: miR-34a sets the "sweet spot" for notch in colorectal cancer stem cells.
abstract: Mechanisms underlying alternative modes of symmetric versus asymmetric stem cell fates are not well understood. In this issue of Cell Stem Cell, Bu et al. (2013) find that miR-34a acts as a toggle switch for Notch signaling that dictates binary symmetric and asymmetric fates in colon cancer stem cells.
authors: Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK. doug.winton@cruk.cam.ac.uk
authors: Douglas J
authors: DJ
authors: Winton