title: A facile synthesis of functionalized dispirooxindole derivatives via a three-component 1,3-dipolar cycloaddition reaction.
abstract: An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.
authors: State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Jun
authors: J
authors: He
authors: Guang
authors: G
authors: Ouyang
authors: Zhixiang
authors: Z
authors: Yuan
authors: Rongsheng
authors: R
authors: Tong
authors: Jianyou
authors: J
authors: Shi
authors: Liang
authors: L
authors: Ouyang
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000737:chemistry*; D007510:Isatin / Q000737:chemistry*; D015394:Molecular Structure; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D006573:Heterocyclic Compounds, 1-Ring; D013882:Thiosemicarbazones; C512188:azomethine; D007510:Isatin
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