title: Percutaneous transluminal angioplasty for peripheral artery disease confers cardiorenal protection.
abstract: The effects of percutaneous transluminal angioplasty (PTA) on hemodynamic parameters are not established. We tested the hypothesis that PTA would achieve reductions in hemodynamic and target organ damage (TOD) measures in patients with peripheral artery disease (PAD). We enrolled 56 consecutive PAD patients who were scheduled to undergo elective PTA procedures. Brachial blood pressure (BP), central BP, left ventricular mass index (LVMI) and urinary microalbumin excretion ratio (UACR) were assessed at baseline and follow-up. The ankle-brachial index in the diseased leg significantly improved after the PTA (P<0.001). Compared with the pretreatment levels, brachial and central BPs, the carotid augmentation index (AI) and central augmentation pressure (AP) were significantly reduced after the PTA, as were LVMI and UACR. The change in AI in the PTA group was significantly associated with the extent of change in LVMI (P=0.002) and marginally associated with the change in UACR (P=0.07), independently of other covariates. In conclusion, in patients with PAD, significant reductions in carotid AI were observed by PTA treatment; these changes may be attributable to improvements in measures of cardiac and renal target organ damage.
authors: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
authors: K
authors: K
authors: Eguchi
authors: A
authors: A
authors: Murakami
authors: T
authors: T
authors: Horaguchi
authors: M
authors: M
authors: Kato
authors: H
authors: H
authors: Miyashita
authors: K
authors: K
authors: Kario
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000175:diagnosis; D017130:Angioplasty; D055109:Ankle Brachial Index; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging / Q000517:prevention & control*; D015897:Comorbidity; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000517:prevention & control*; D008297:Male; D058729:Peripheral Arterial Disease / Q000628:therapy; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014463:Ultrasonography
references: Eur J Vasc Endovasc Surg. 1996 May;11(4):421-4
references: 8846175
references: Hypertension. 2005 Jul;46(1):200-4
references: 15911742
references: Circulation. 2006 Mar 21;113(11):e463-654
references: 16549646
references: J Hypertens. 2008 May;26(5):1017-24
references: 18398345
references: J Am Coll Cardiol. 2007 Jul 3;50(1):1-13
references: 17601538
references: J Am Coll Cardiol. 2008 Apr 22;51(16):1588-96
references: 18420103
references: Hypertension. 2008 Sep;52(3):478-83
references: 18695144
references: Hypertension. 2000 Nov;36(5):755-9
references: 11082139
references: Hypertens Res. 2009 Jan;32(1):3-107
references: 19300436
references: Circulation. 1998 Jan 6-13;97(1):48-54
references: 9443431
references: Hypertension. 2005 Feb;45(2):198-202
references: 15655123
references: J Hypertens. 2008 Oct;26(10):1928-34
references: 18806616
references: JAMA. 2008 Jul 9;300(2):197-208
references: 18612117
references: Hypertension. 2004 Dec;44(6):e10-1
references: 15492135
references: J Hypertens. 2010 Dec;28(12):2462-7
references: 20720500
references: Diabetes Care. 2011 Jan;34 Suppl 1:S11-61
references: 21193625
references: Physiol Meas. 2007 Sep;28(9):1045-56
references: 17827652
references: Pain. 1983 Sep;17(1):45-56
references: 6226917
references: Nephrology (Carlton). 2006 Feb;11(1):9-14
references: 16509925
references: Atherosclerosis. 1997 May;131(1):115-25
references: 9180252
references: Circulation. 1987 Aug;76(2):254-8
references: 2955954
references: Int J Epidemiol. 1996 Dec;25(6):1172-81
references: 9027521
references: J Am Coll Cardiol. 1993 Dec;22(7):1873-80
references: 8245342
references: Am J Cardiol. 1986 Feb 15;57(6):450-8
references: 2936235
references: J Cardiovasc Pharmacol. 2007 Apr;49(4):221-7
references: 17438407
references: Cerebrovasc Dis. 2010;29(6):546-54
references: 20375496
references: Circulation. 2003 Oct 28;108(17):2154-69
references: 14581387