title: The neural basis of inhibitory effects of semantic and phonological neighbors in spoken word production.
abstract: Theories of word production and word recognition generally agree that multiple word candidates are activated during processing. The facilitative and inhibitory effects of these "lexical neighbors" have been studied extensively using behavioral methods and have spurred theoretical development in psycholinguistics, but relatively little is known about the neural basis of these effects and how lesions may affect them. This study used voxel-wise lesion overlap subtraction to examine semantic and phonological neighbor effects in spoken word production following left hemisphere stroke. Increased inhibitory effects of near semantic neighbors were associated with inferior frontal lobe lesions, suggesting impaired selection among strongly activated semantically related candidates. Increased inhibitory effects of phonological neighbors were associated with posterior superior temporal and inferior parietal lobe lesions. In combination with previous studies, these results suggest that such lesions cause phonological-to-lexical feedback to more strongly activate phonologically related lexical candidates. The comparison of semantic and phonological neighbor effects and how they are affected by left hemisphere lesions provides new insights into the cognitive dynamics and neural basis of phonological, semantic, and cognitive control processes in spoken word production.
authors: Moss Rehabilitation Research Institute, Elkins Park, PA 19027, USA. dan@danmirman.org
authors: Daniel
authors: D
authors: Mirman
authors: Kristen M
authors: KM
authors: Graziano
mesh_terms: D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D010700:Phonetics; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D012660:Semantics; D014057:Tomography, X-Ray Computed; D014796:Visual Perception; D014825:Vocabulary
references: Psychol Rev. 1982 Jan;89(1):60-94
references: 7058229
references: Brain. 2009 Dec;132(Pt 12):3411-27
references: 19942676
references: Hum Brain Mapp. 2009 Nov;30(11):3596-608
references: 19365800
references: J Neurosci. 2010 Aug 18;30(33):11057-61
references: 20720112
references: J Neuropsychol. 2019 Jun;13(2):183-197
references: 29411521
references: Brain Lang. 2011 Jun;117(3):110-22
references: 20961612
references: Med Image Anal. 2006 Jun;10(3):397-412
references: 15948659
references: Neuroreport. 2006 Aug 21;17(12):1293-6
references: 16951572
references: Nat Rev Neurosci. 2007 May;8(5):393-402
references: 17431404
references: Cortex. 2013 Mar;49(3):658-67
references: 22482693
references: Nat Rev Neurosci. 2012 Jan 05;13(2):135-45
references: 22218206
references: Behav Res Methods. 2005 Nov;37(4):547-59
references: 16629288
references: Cortex. 2009 May;45(5):641-9
references: 19084219
references: J Cogn Neurosci. 2010 Feb;22(2):213-24
references: 19301991
references: J Cogn Neurosci. 2011 Dec;23(12):3778-90
references: 21563885
references: Psychol Rev. 1997 Oct;104(4):801-38
references: 9337631
references: Proc Natl Acad Sci U S A. 2011 May 17;108(20):8520-4
references: 21540329
references: Brain Lang. 2011 Dec;119(3):119-28
references: 21256582
references: J Cogn Neurosci. 2008 Sep;20(9):1698-710
references: 18345989
references: J Cogn Neurosci. 2007 May;19(5):761-75
references: 17488203
references: Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):322-7
references: 19118194
references: J Cogn Neurosci. 2007 Jul;19(7):1067-80
references: 17583984
references: Cogn Sci. 2015 Apr;39(3):538-58
references: 25155249
references: Cortex. 2012 Jul;48(7):826-48
references: 21159333
references: Cogn Affect Behav Neurosci. 2011 Mar;11(1):32-43
references: 21264640
references: Neuropsychologia. 2012 Jul;50(8):1990-7
references: 22571932
references: Exp Brain Res. 2010 Oct;206(2):197-208
references: 20571784
references: J Mem Lang. 2010 Feb 1;62(2):113-134
references: 20161591
references: Neuropsychologia. 2006;44(12):2209-21
references: 16842827
references: Brain. 2012 Dec;135(Pt 12):3799-814
references: 23171662
references: Brain Lang. 1979 Jul;8(1):34-50
references: 476474
references: Neuroimage. 2002 Jan;15(1):273-89
references: 11771995
references: Nat Rev Neurosci. 2004 Oct;5(10):813-9
references: 15378041
references: Nat Rev Neurosci. 2007 Dec;8(12):976-87
references: 18026167
references: J Cogn Neurosci. 2011 Mar;23(3):593-603
references: 20350185
references: Radiology. 1977 Jun;123(3):653-60
references: 860034
references: Ear Hear. 1998 Feb;19(1):1-36
references: 9504270
references: Cogn Sci. 2007 Feb;31(1):133-56
references: 21635290
references: Trends Cogn Sci. 2011 Nov;15(11):527-36
references: 22001867
references: Brain Lang. 2012 Jun;121(3):273-88
references: 22498237
references: Behav Res Methods. 2007 Aug;39(3):445-59
references: 17958156
references: J Comput Assist Tomogr. 1998 Mar-Apr;22(2):324-33
references: 9530404
references: Nat Neurosci. 2009 Apr;12(4):515-22
references: 19252496
references: J Exp Psychol Learn Mem Cogn. 2008 Jan;34(1):65-79
references: 18194055
references: Mem Cognit. 2003 Sep;31(6):842-55
references: 14651293
references: Aphasiology. 2012;26(3-4):338-354
references: 24976669
references: Psychol Rev. 2012 Apr;119(2):417-30
references: 22352357
references: Nature. 1996 Nov 14;384(6605):159-61
references: 8906789
references: Cognition. 2004 May-Jun;92(1-2):179-229
references: 15037130
references: Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1518-23
references: 23300283
references: Soc Cogn Affect Neurosci. 2009 Dec;4(4):417-22
references: 20042432