title: Effects of space mission factors on the morphology and function of endothelial cells.
abstract: The structure and functions of endothelial cells after space mission were studied by electron and laser confocal microscopy, image analysis, and MTT test. The endothelial cells changed significantly (proliferative activity, size, contours, shape, distribution of mitochondria and microtubules) in comparison with controls on the Earth. These changes indicated injuries in the cytoskeleton and impairment of the barrier function of the cells, which presumably contributed to the development of endothelial dysfunction.
authors: Volgograd State Medical University, Russia.
authors: M Yu
authors: MY
authors: Kapitonova
authors: S L
authors: SL
authors: Kuznetsov
authors: G R A
authors: GR
authors: Froemming
authors: S
authors: S
authors: Muid
authors: M N K
authors: MN
authors: Nor-Ashikin
authors: S
authors: S
authors: Otman
authors: A R M
authors: AR
authors: Shahir
authors: H
authors: H
authors: Nawawi
mesh_terms: D002462:Cell Membrane / Q000648:ultrastructure; D049109:Cell Proliferation; D048430:Cell Shape; D048429:Cell Size; D002478:Cells, Cultured; D061307:Human Umbilical Vein Endothelial Cells / Q000502:physiology* / Q000648:ultrastructure; D008928:Mitochondria / Q000378:metabolism; D013026:Space Flight; D014404:Tubulin / Q000378:metabolism; D014893:Weightlessness
chemical_list: D014404:Tubulin