title: Attenuation correction for the HRRT PET-scanner using transmission scatter correction and total variation regularization.
abstract: In the standard software for the Siemens high-resolution research tomograph (HRRT) positron emission tomography (PET) scanner the most commonly used segmentation in the μ -map reconstruction for human brain scans is maximum a posteriori for transmission (MAP-TR). Bias in the lower cerebellum and pons in HRRT brain images have been reported. The two main sources of the problem with MAP-TR are poor bone/soft tissue segmentation below the brain and overestimation of bone mass in the skull.
  
  
  METHODS
  We developed the new transmission processing with total variation (TXTV) method that introduces scatter correction in the μ-map reconstruction and total variation filtering to the transmission processing.
  
  
  RESULTS
  Comparing MAP-TR and the new TXTV with gold standard CT-based attenuation correction, we found that TXTV has less bias as compared to MAP-TR. We also compared images acquired at the HRRT scanner using TXTV to the GE Advance scanner images and found high quantitative correspondence. TXTV has been used to reconstruct more than 4000 HRRT scans at seven different sites with no reports of biases.
  
  
  CONCLUSIONS
  TXTV-based reconstruction is recommended for human brain scans on the HRRT.
authors: Department of Clnical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark. sune@pet.rh.dk
authors: Sune H
authors: SH
authors: Keller
authors: Claus
authors: C
authors: Svarer
authors: Merence
authors: M
authors: Sibomana
mesh_terms: D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging; D019788:Fluorodeoxyglucose F18 / Q000032:analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D059906:Neuroimaging; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000379:methods*; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18