title: Induction of TNF-α production by metal complexes of γ-globulin fraction proteins and copper and zinc cations.
abstract: Plasma γ-globulin fraction proteins, copper and zinc cations, and metal complexes of these cations and human serum γ-globulin induce the production of TNF-α by human blood cells. The protein modified by zinc cations is by 1.4-1.7 times more potent (p<0.001-0.01) than control γ-globulin in inducing the production of TNF-α, while metal complex formed by γ-globulin and copper is by 1.9-2.2 times more potent that the control protein (p<0.001). Under conditions of experimental induction, TNF-α is produced as a typical early response cytokine. During long-term incubation, copper cations lose the ability to induce TNF-α production, while in combination with γ-globulin these cations produce a synergistic effect with the control protein.
authors: Laboratory of Cell-to-Cell Interactions, N. F. Gamaleya Institute of Epidemiology and Microbiology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia. cheknev@gamaleya.org
authors: S B
authors: SB
authors: Cheknev
authors: I E
authors: IE
authors: Efremova
authors: M A
authors: MA
authors: Apresova
authors: A A
authors: AA
authors: Babajantz
mesh_terms: D002478:Cells, Cultured; D056831:Coordination Complexes / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D015032:Zinc / Q000737:chemistry*; D055545:gamma-Globins / Q000494:pharmacology*
chemical_list: D056831:Coordination Complexes; D014409:Tumor Necrosis Factor-alpha; D055545:gamma-Globins; D003300:Copper; D015032:Zinc