title: Radiofluorination using aluminum-fluoride (Al18F).
abstract: Targeted agents are increasingly used for treating cancer and other diseases, but patients may need to be carefully selected to maximize the potential for therapeutic benefit. One way to select patients is to bind an imaging radionuclide to a targeting agent of interest, so that its uptake in specific sites of disease can be visualized by positron-emission tomography (PET) or single-photon emission computed tomography.18F is the most commonly used radionuclide for PET imaging. Its half-life of approximately 2 h is suited for same-day imaging of many compounds that clear quickly from the body to allow visualization of uptake in the intended target. A significant impediment to its use, however, is the challenging coupling of 18F to a carbon atom of the targeting agent. Because fluorine binds to aluminum, we developed a procedure where the Al18F complex could be captured by a chelate, thereby greatly simplifying the way that imaging agents can be fluorinated for PET imaging. This article reviews our experience with this technology.
authors: Immunomedics, Inc,, 300 The American Road, Morris Plains, NJ 07950, USA. bmcbride@immunomedics.com.
authors: William J
authors: WJ
authors: McBride
authors: Robert M
authors: RM
authors: Sharkey
authors: David M
authors: DM
authors: Goldenberg
references: Eur J Nucl Med Mol Imaging. 2008 May;35(5):1008-18
references: 18157531
references: J Nucl Med. 2010 Mar;51(3):454-61
references: 20150268
references: Biochem Biophys Res Commun. 1988 Sep 30;155(3):1194-200
references: 3178801
references: J Nucl Med. 2012 Jun;53(6):947-52
references: 22570329
references: J Med Chem. 2002 Aug 1;45(16):3458-64
references: 12139456
references: Bioconjug Chem. 2011 Sep 21;22(9):1793-803
references: 21805975
references: Nat Med. 2005 Nov;11(11):1250-5
references: 16258537
references: Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12462-7
references: 17626788
references: J Inorg Biochem. 2002 Jan 1;88(1):1-6
references: 11750018
references: J Nucl Med. 2013 May;54(5):691-8
references: 23554506
references: Am J Nucl Med Mol Imaging. 2013;3(1):44-56
references: 23342300
references: Mol Cancer Ther. 2010 Apr;9(4):1019-27
references: 20354120
references: Anal Chem. 2005 Apr 15;77(8):2437-49
references: 15828779
references: Angew Chem Int Ed Engl. 2008;47(47):8998-9033
references: 18988199
references: J Nucl Med. 2000 Oct;41(10):1704-13
references: 11038002
references: Eur J Nucl Med. 1998 Feb;25(2):201-12
references: 9473271
references: Theranostics. 2012;2(5):481-501
references: 22737187
references: Bioorg Med Chem. 2012 Oct 1;20(19):5941-7
references: 22917858
references: Nucl Med Biol. 1994 Nov;21(8):1023-34
references: 9234360
references: J Nucl Med. 2011 Feb;52(2):270-8
references: 21233180
references: Bioconjug Chem. 2006 Sep-Oct;17(5):1294-313
references: 16984141
references: Eur J Nucl Med Mol Imaging. 2012 Mar;39(3):463-73
references: 22170321
references: Theranostics. 2012;2(10):999-1009
references: 23139727
references: PLoS One. 2012;7(5):e37506
references: 22624041
references: Theranostics. 2013;3(3):181-9
references: 23471211
references: J Am Chem Soc. 2012 Oct 24;134(42):17456-8
references: 23061667
references: Theranostics. 2012;2(5):523-40
references: 22737190
references: Eur J Nucl Med Mol Imaging. 2011 Sep;38(9):1732-41
references: 21617974
references: Appl Radiat Isot. 2012 Jan;70(1):200-4
references: 21890371
references: J Nucl Med. 2011 Sep;52(9):1441-8
references: 21852355
references: Bioconjug Chem. 2010 Jul 21;21(7):1331-40
references: 20540570
references: J Nucl Med. 2009 Jun;50(6):991-8
references: 19443594
references: Chem Rev. 2008 May;108(5):1501-16
references: 18426240
references: Curr Top Med Chem. 2010;10(16):1669-79
references: 20583991
references: J Nucl Med. 2012 Jan;53(1):146-53
references: 22173842
references: Dalton Trans. 2011 Jun 21;40(23):6196-205
references: 21499604
references: Crit Rev Oral Biol Med. 2003;14(2):100-14
references: 12764073
references: J Med Chem. 2012 Apr 12;55(7):3155-62
references: 22443100
references: Bioconjug Chem. 2011 May 18;22(5):894-902
references: 21443270
references: Eur J Nucl Med Mol Imaging. 2012 Apr;39(4):683-92
references: 22274731
references: J Biol Chem. 1992 Apr 5;267(10):6710-8
references: 1551879
references: Chem Commun (Camb). 2011 Sep 14;47(34):9732-4
references: 21776539
references: Bioconjug Chem. 2012 Mar 21;23(3):538-47
references: 22273147
references: Tumour Biol. 2012 Apr;33(2):427-34
references: 22009690
references: Contrast Media Mol Imaging. 2013 May-Jun;8(3):238-45
references: 23606427
references: Science. 1982 Mar 19;215(4539):1511-3
references: 7199757
references: Bioconjug Chem. 2011 Dec 21;22(12):2415-22
references: 22026940