title: A 12-month, prospective, evaluator-blinded study of small gel particle hyaluronic acid filler in the correction of temporal fossa volume loss.
abstract: OBJECTIVE
  The primary objective of this study is to examine the use and persistency of small gel particle hyaluronic acid (SGP-HA) filler (Restylane®; Medicis Aesthetics Inc, Scottsdale, AZ) in the treatment of temporal fossa volumization over a 12-month follow-up, and determine local adverse events (AEs).
  
  
  METHODS
  This is a US Food and Drug Administration-approved, blinded, prospective, single-center, open-label trial enrolling 20 subjects undergoing subcutaneous injection of SGP-HA for rejuvenation of the temples. Primary outcomes were measured using a standardized grading system&mdash;the Hollowness Severity Rating Scale (HSRS)&mdash;at each visit by the treating investigator, a blinded physician assessment of randomized photos using the HSRS, and patient questionnaires over a 12-month period. AEs were monitored by the investigator and via patient diaries.
  
  
  RESULTS
  At weeks 4, 12, and 24, and month 12, all graders (ie, investigator, blinded physician assessor, and patients) reported improvement overall in hollowness. At baseline, temporal fossa hollowness was measured as moderate to severe. At week 4 to month 12, temporal fossa was graded at none or only mild hollowness. No touch-ups were necessary at week 4 on all subjects. All AEs were mild or moderate and resolved within 2 weeks.
  
  
  CONCLUSIONS
  Our study demonstrates clinically significant efficacy and safety in the use of Restylane for temple augmentation and, thus, facial rejuventation.
authors: Moradi MD, Vista, CA, USA. moradimd@gmail.com
authors: Amir
authors: A
authors: Moradi
authors: Azadeh
authors: A
authors: Shirazi
authors: Jeanette
authors: J
authors: Moradi
mesh_terms: D000328:Adult; D000375:Aging; D003357:Cosmetic Techniques / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D011446:Prospective Studies; D012060:Rejuvenation; D012720:Severity of Illness Index; D016037:Single-Blind Method; D011795:Surveys and Questionnaires; D013701:Temporal Bone; D016896:Treatment Outcome
chemical_list: D005782:Gels; D006820:Hyaluronic Acid; C445361:Restylane