title: Treatment of resistant bacterial infections in children: thinking inside and outside the box.
abstract: Antimicrobial resistance of bacteria causing pediatric infections has become more common and complicated in recent years. Although formerly confined to hospital settings, multi-drug resistant bacteria now also cause community-acquired infections. Treatment of infections caused by resistant pathogens is difficult, necessitating thinking both inside and outside the box. Determination of the precise minimal inhibitory concentration (MIC) is often crucial for selecting the most appropriate antibiotics, their doses, and use of prolonged infusions. For some multiply-resistant bacteria, off-label use of antibiotics, sometimes with no evidence from controlled studies ("salvage therapy") is unavoidable.
authors: Sackler Faculty of Medicine, Department of Pediatrics A, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. gilat@orange.net.il
authors: Gilat
authors: G
authors: Livni
authors: Shai
authors: S
authors: Ashkenazi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology*; D002648:Child; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents