title: The activity of valproic Acid in the treatment of refractory hyperleukocytosis in a child with acute lymphoblastic leukemia.
abstract: Hyperleukocytosis may be associated with an early morbidity and mortality due to leukostasis. Cytoreductive therapies-such as steroids, hydroxiurea, exchange transfusion, and leukapheresis-have been used for the prevention of leukostasis. Herein, the valproic acid used for the treatment of the hyperleukocytosis did not respond to known therapies in a child; lymphoblastic lymphoma developed bone marrow relapse under the treatment is discussed.
authors: Dogan
authors: D
authors: Kose
authors: Yavuz
authors: Y
authors: Koksal
mesh_terms: D002648:Child; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007964:Leukocytosis / Q000150:complications / Q000188:drug therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000517:prevention & control*; D012008:Recurrence; D014635:Valproic Acid / Q000008:administration & dosage*
chemical_list: D004791:Enzyme Inhibitors; D014635:Valproic Acid