title: [Bacteriological substantiation of the antituberculosis effect of immunotropic drug tubosan].
abstract: The antituberculosis effect of tubosan registered in the Russian Federation as an immunostimulant drug has been studied on a series of 53 clinical strains of Mycobacterium tuberculosis (MBT). It is established that tubosan produces a bactericidal effect on drug-sensitive MBT strains and a bacteriostatic effect on resistant MBT strains. Use of tubosan for the treatment of 102 patients with drug-resistant destructive tuberculosis showed evident clinical-radiological involution process, with prospects of clinical recovery for 75% of patients. Results of this study show that tubosan possesses both antituberculosis and immunostimulant properties. It is recommended to use tubosan for complex treatment of patients with drug-resistant tuberculosis.
authors: B S
authors: BS
authors: Kibrik
authors: A V
authors: AV
authors: Pavlov
authors: O G
authors: OG
authors: Chelnokova
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D016022:Case-Control Studies; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D012426:Russia; D013450:Sulfones / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology
chemical_list: D000276:Adjuvants, Immunologic; D000995:Antitubercular Agents; D006834:Hydrazines; D011743:Pyrimidines; D013450:Sulfones