title: Human progenitor cells for bone engineering applications.
abstract: In this report, the authors review the human skeleton and the increasing burden of bone deficiencies, the limitations encountered with the current treatments and the opportunities provided by the emerging field of cell-based bone engineering. Special emphasis is placed on different sources of human progenitor cells, as well as their pros and cons in relation to their utilization for the large-scale construction of functional bone-engineered substitutes for clinical applications. It is concluded that, human pluripotent stem cells represent a valuable source for the derivation of progenitor cells, which combine the advantages of both embryonic and adult stem cells, and indeed display high potential for the construction of functional substitutes for bone replacement therapies.
authors: New York Stem Cell Foundation, New York, NY 10032, USA. gmdepeppo@nyscf.org
authors: G M
authors: GM
authors: de Peppo
authors: P
authors: P
authors: Thomsen
authors: C
authors: C
authors: Karlsson
authors: R
authors: R
authors: Strehl
authors: A
authors: A
authors: Lindahl
authors: J
authors: J
authors: Hyllner
mesh_terms: D053687:Adult Stem Cells / Q000637:transplantation*; D000818:Animals; D001851:Bone Diseases, Metabolic / Q000628:therapy; D001861:Bone Regeneration; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000637:transplantation*; D006801:Humans; D010012:Osteogenesis; D044968:Regenerative Medicine; D023822:Tissue Engineering