title: Signet ring lobular carcinoma in situ as a part of the "Rosen Triad" (tubular carcinoma, columnar cell hyperplasia, and lobular carcinoma in situ).
abstract: OBJECTIVE
  The association of tubular carcinoma, columnar cell lesions and lobular carcinoma in situ, also known as the "Rosen Triad", may be encountered in breast biopsies performed for evaluation of mammographically detected microcalcifications.
  
  
  METHODS
  A case in which tubular carcinoma and columnar cell hyperplasia were associated with a histologically unusual form of signet ring lobular carcinoma in situ is presented. Signet ring non-invasive lobular carcinoma is classified as high-grade lobular carcinoma in situ, but herein is associated with changes that belong to the molecular pathway of low-grade mammary neoplasia.
  
  
  CONCLUSIONS
  We reported the case of lobular carcinoma in situ associated with columnar cell hyperplasia and tubular carcinoma, in which the lobular carcinoma in situ was presented in a histologically unexpected form comprised predominantly of signet ring cells.
authors: Clinical Hospital Split, Institute of Pathology, Split, Croatia. jbezic@mefst.hr
authors: Josko
authors: J
authors: Bezic
authors: Dijana
authors: D
authors: Gugic
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D001706:Biopsy; D001943:Breast Neoplasms / Q000473:pathology*; D002278:Carcinoma in Situ / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000473:pathology*; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D060787:Neoplasm Grading