title: [Description of a patient with schizophrenia and coexisting megadose lorazepam dependence with slightly expressed withdrawl symptoms during drug reduction. A case report].
abstract: The aim of this article is to present a patient with a megadose lorazepam dependence and slightly marked withdrawal symptoms during detoxication. The authors describe the case of 42 year old man who has been addicted to lorazepam (125 mg/d) for 2 years. On the ground of medical examination, anamnesis and hospital observation paranoid schizophrenia and lorazepam dependence syndrome was recognized. Despite relatively rapid reduction of lorazepam the withdrawal symptoms were slightly expressed. At the beginning of detoxication sleep disorders, feeling of "less looseness" and anxiety was observed. Review of medical database revealed other cases of megadose lorazepam dependence (95-300 mg/d). However in those cases withdrawal symptoms were distinct and the medical intervention was needed.
authors: Katedra i Oddział Kliniczny Psychiatrii, SUM.
authors: Aleksandra
authors: A
authors: Schylla
authors: Piotr
authors: P
authors: Scisło
authors: Karina
authors: K
authors: Badura-Brzoza
authors: Natalia
authors: N
authors: Pasierb
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008140:Lorazepam / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D012563:Schizophrenia, Paranoid / Q000150:complications*; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000209:etiology*
chemical_list: D014151:Anti-Anxiety Agents; D008140:Lorazepam