title: Exposure to light at night accelerates aging and spontaneous uterine carcinogenesis in female 129/Sv mice.
abstract: The effect of the constant illumination on the development of spontaneous tumors in female 129/Sv mice was investigated. Forty-six female 129/Sv mice starting from the age of 2 mo were kept under standard light/dark regimen [12 h light (70 lx):12 hr dark; LD, control group], and 46 of 129/Sv mice were kept under constant illumination (24 h a day, 2,500 lx, LL) from the age of 5 mo until to natural death. The exposure to the LL regimen significantly accelerated body weight gain, increased body temperature as well as acceleration of age-related disturbances in estrous function, followed by significant acceleration of the development of the spontaneous uterine tumors in female 129/Sv mice. Total tumor incidence as well as a total number of total or malignant tumors was similar in LL and LD group (p > 0.05). The mice from the LL groups survived less than those from the LD group (χ ( 2) = 8.5; p = 0.00351, log-rank test). According to the estimated parameters of the Cox's regression model, constant light regimen increased the relative risk of death in female mice compared with the control (LD) group (p = 0.0041). The data demonstrate in the first time that the exposure to constant illumination was followed by the acceleration of aging and spontaneous uterine tumorigenesis in female 129/Sv mice.
authors: Laboratory of Carcinogenesis and Aging, N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia.
authors: Irina G
authors: IG
authors: Popovich
authors: Mark A
authors: MA
authors: Zabezhinski
authors: Andrei V
authors: AV
authors: Panchenko
authors: Tatiana S
authors: TS
authors: Piskunova
authors: Anna V
authors: AV
authors: Semenchenko
authors: Maragriata L
authors: ML
authors: Tyndyk
authors: Maria N
authors: MN
authors: Yurova
authors: Vladimir N
authors: VN
authors: Anisimov
mesh_terms: D000375:Aging / Q000528:radiation effects*; D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic; D030762:Estrous Cycle / Q000528:radiation effects; D005260:Female; D008027:Light; D051379:Mice; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000209:etiology* / Q000378:metabolism
keywords: 129/Sv mice; lifespan; light at night; tumorigenesis
references: Cancer Causes Control. 2010 Dec;21(12):2059-68
references: 20680434
references: Cell Cycle. 2011 Dec 1;10(23):4162-9
references: 22101268
references: Aging (Albany NY). 2010 Nov;2(11):760-74
references: 21084729
references: Occup Environ Med. 2011 Feb;68(2):154-62
references: 20962033
references: Sci Aging Knowledge Environ. 2006 Jun 28;2006(10):pe19
references: 16807483
references: Nat Rev Genet. 2005 Jul;6(7):544-56
references: 15951747
references: Aging (Albany NY). 2010 May;2(5):285-97
references: 20519775
references: Methods Mol Biol. 2007;371:227-36
references: 17634585
references: Carcinogenesis. 1997 Aug;18(8):1549-53
references: 9276629
references: IARC Monogr Eval Carcinog Risks Hum. 2010;98:9-764
references: 21381544
references: Neuro Endocrinol Lett. 2001 Dec;22(6):441-7
references: 11781542
references: Braz J Med Biol Res. 2004 Jul;37(7):987-95
references: 15264005
references: Endocr Relat Cancer. 2003 Jun;10(2):153-9
references: 12790777
references: Life Sci. 1999;64(26):2523-34
references: 10403512
references: Int J Epidemiol. 2009 Aug;38(4):963-70
references: 19380369
references: Biochim Biophys Acta. 2006 May-Jun;1757(5-6):573-89
references: 16678784
references: Aging (Albany NY). 2011 May;3(5):479-93
references: 21566258
references: Neuro Endocrinol Lett. 2006 Feb-Apr;27(1-2):35-52
references: 16648818
references: Adv Gerontol. 2007;20(2):70-5
references: 18306692
references: Lancet Oncol. 2007 Dec;8(12):1065-6
references: 19271347
references: Int J Cancer. 2003 Jan 20;103(3):300-5
references: 12471612
references: Chronobiol Int. 2009 Jan;26(1):108-25
references: 19142761
references: Cancer Lett. 2001 Feb 10;163(1):51-7
references: 11163108
references: Aging (Albany NY). 2009 Oct 02;1(10):855-65
references: 20157558
references: J Natl Cancer Inst. 2003 Jun 4;95(11):825-8
references: 12783938
references: Occup Environ Med. 2012 Aug;69(8):551-6
references: 22645325
references: Crit Rev Oncol Hematol. 2003 Jun;46(3):221-34
references: 12791421
references: J Pineal Res. 2003 Oct;35(3):204-11
references: 12932205
references: Nat Rev Neurosci. 2012 Mar 07;13(5):325-35
references: 22395806
references: J Natl Cancer Inst. 2001 Oct 17;93(20):1563-8
references: 11604480
references: Aging (Albany NY). 2010 Mar 20;2(2):76-7
references: 20354267
references: Exp Gerontol. 1979;14(4):161-74
references: 225186
references: Vopr Onkol. 2008;54(3):332-7
references: 18652239
references: Aging (Albany NY). 2011 Aug;3(8):813-7
references: 21869460
references: Aging (Albany NY). 2010 Dec;2(12):936-44
references: 21149897
references: Mol Med. 2012 Dec 06;18:1249-60
references: 22811066