title: Thalamic control of neocortical area formation in mice.
abstract: The mammalian neocortex undergoes dramatic transformation during development, from a seemingly homogenous sheet of neuroepithelial cells into a complex structure that is tangentially divided into discrete areas. This process is thought to be controlled by a combination of intrinsic patterning mechanisms within the cortex and afferent axonal projections from the thalamus. However, roles of thalamic afferents in the formation of areas are still poorly understood. In this study, we show that genetically increasing or decreasing the size of the lateral geniculate nucleus of the mouse thalamus resulted in a corresponding change in the size of the primary visual area. Furthermore, elimination of most thalamocortical projections from the outset of their development resulted in altered areal gene expression patterns, particularly in the primary visual and somatosensory areas, where they lost sharp boundaries with adjacent areas. Together, these results demonstrate the critical roles of thalamic afferents in the establishment of neocortical areas.
authors: Department of Neuroscience, Developmental Biology Center, Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors: Tou Yia
authors: TY
authors: Vue
authors: Melody
authors: M
authors: Lee
authors: Yew Ei
authors: YE
authors: Tan
authors: Zachary
authors: Z
authors: Werkhoven
authors: Lynn
authors: L
authors: Wang
authors: Yasushi
authors: Y
authors: Nakagawa
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics; D002452:Cell Count; D048429:Cell Size; D004622:Embryo, Mammalian; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology*; D053823:Hedgehog Proteins / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D019579:Neocortex / Q000196:embryology* / Q000254:growth & development* / Q000378:metabolism; D011506:Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D022661:RNA, Untranslated; D013788:Thalamus / Q000502:physiology*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins; D011506:Proteins; D012333:RNA, Messenger; D022661:RNA, Untranslated; C513182:Gbx2 protein, mouse; C110853:Gt(ROSA)26Sor non-coding RNA, mouse; C420992:Olig3 protein, mouse; C465570:Shh protein, mouse
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