title: Early skin testing is effective for diagnosis of hypersensitivity reactions occurring during anesthesia.
abstract: Allergic skin tests have to be performed 4-6 weeks after an allergic anesthetic reaction. Patients with allergic reactions during anesthesia were prospectively included (n = 44). Skin tests were performed in two stages: (i) Stage 1 (S1), 0-4 days after the reaction; and (ii) Stage 2 (S2), 4-8 weeks after. Five (11.5%) surgical procedures were suspended due to the reaction. Positive skin tests were obtained in 25/44 patients (57%). Allergic diagnosis was carried out at S1 in 15/25 (60%) and at S2 in 10/25 (40%). Three patients resulted positive only in S1. Overall agreement among S1 and S2 skin tests was 70.45%. The kappa statistic was 0.41 (P-value = 0.002). Odds ratio of obtaining a false negative in S1 (compared with S2) was 3.33. Early allergological study is useful, could minimize false negatives, but should be considered as a complement to late skin tests.
authors: Department of Anesthesia, Medical School, Clínica Universidad de Navarra, Pamplona, Spain.
authors: A
authors: A
authors: Lafuente
authors: G
authors: G
authors: Javaloyes
authors: F
authors: F
authors: Berroa
authors: M J
authors: MJ
authors: Goikoetxea
authors: R
authors: R
authors: Moncada
authors: J M
authors: JM
authors: Núñez-Córdoba
authors: P
authors: P
authors: Cabrera-Freitag
authors: C
authors: C
authors: D'Amelio
authors: M L
authors: ML
authors: Sanz
authors: G
authors: G
authors: Gastaminza
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000707:Anaphylaxis / Q000139:chemically induced / Q000175:diagnosis*; D000758:Anesthesia; D002648:Child; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D042241:Early Diagnosis; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012882:Skin Tests; D055815:Young Adult