title: [Neural respiratory drive and nocturnal hypoventilation in patients with chronic obstructive pulmonary disease].
abstract: OBJECTIVE
  To explore the effects of neural respiratory drive on ventilation in patients with chronic obstructive pulmonary disease (COPD) during sleep.
  
  
  METHODS
  Diaphragm electromyogram (EMG) from a multipair esophageal electrodes and airflow derived from pneumotachography were recorded during overnight polysomnography in 13 patients with stable COPD recruited from outpatient clinic of First Affiliated Hospital of Guangzhou Medical College from May 2010 to May 2011. Changes in diaphragm EMG and ventilation during wakefulness and different sleep stages were observed.
  
  
  RESULTS
  Diaphragm EMG decreased by 26% in non-rapid eye movement sleep (NREM) stage and 39% in rapid eye movement (REM) as compared with wakefulness. Coinciding with change in diaphragm EMG, ventilation (VE) (ml×min(-1)×kg(-1)) significantly decreased from wakefulness (156 ± 53) ml×min(-1)×kg(-1) to steady NREM stage (112 ± 35) ml×min(-1)×kg(-1) (P < 0.05) and further decreased from NREM stage to REM stage (95 ± 27) ml×min(-1)×kg(-1) (P < 0.05). Oxygen saturation also decreased significantly from 97.1% ± 1.8% in wakefulness to REM stage (94.0% ± 3.9%) (P < 0.01).
  
  
  CONCLUSIONS
  Reduced neural respiratory drive contributes to nocturnal hypoventilation in COPD patients.
authors: Department of Respiratory Medicine, Guangzhou Medical College, Guangzhou, China.
authors: Jing
authors: J
authors: Xu
authors: Hong
authors: H
authors: Yuan
authors: Ying-xin
authors: YX
authors: Wu
authors: Si-chang
authors: SC
authors: Xiao
authors: Han-jia
authors: HJ
authors: Zhang
authors: Yuan-ming
authors: YM
authors: Luo
mesh_terms: D000328:Adult; D000368:Aged; D003964:Diaphragm / Q000503:physiopathology*; D004576:Electromyography; D006801:Humans; D007040:Hypoventilation / Q000503:physiopathology; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D020182:Sleep Apnea, Central / Q000503:physiopathology*; D012894:Sleep Stages