title: Nano-BaSO4: a novel antimicrobial additive to pellethane.
abstract: Hospital-acquired infections remain a costly clinical problem. Barium sulfate (BaSO4, in micron particulate form) is a common radiopacifying agent that is added to catheters and endotracheal tubes. Due to the recently observed ability of nanostructured surface features to decrease functions of bacteria without the aid of antibiotics, the objective of this in vitro study was to incorporate nano-barium sulfate into pellethane and determine the antimicrobial properties of the resulting composites. The results demonstrated for the first time that the incorporation of nano-barium sulfate into pellethane enhanced antimicrobial properties (using Staphylococcus aureus and Pseudomonas aeruginosa) compared to currently used pellethane; properties that warrant further investigation for a wide range of clinical applications.
authors: Program in Bioengineering and Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA.
authors: George E
authors: GE
authors: Aninwene
authors: David
authors: D
authors: Stout
authors: Zifan
authors: Z
authors: Yang
authors: Thomas J
authors: TJ
authors: Webster
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001466:Barium Sulfate / Q000737:chemistry* / Q000494:pharmacology; D015169:Colony Count, Microbial; D003287:Contrast Media; D008422:Materials Testing; D050296:Microbial Viability / Q000187:drug effects; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties
chemical_list: D000890:Anti-Infective Agents; D003287:Contrast Media; D011140:Polyurethanes; D001466:Barium Sulfate
keywords: antimicrobial polymer; dynamic contact microbial testing; hospital-acquired infections; radiopaque agent; surface roughness
references: Annu Rev Microbiol. 1995;49:711-45
references: 8561477
references: Int J Nanomedicine. 2011;6:1463-73
references: 21796248
references: Nat Rev Microbiol. 2004 Feb;2(2):95-108
references: 15040259
references: J Gen Microbiol. 1989 May;135(5):1291-303
references: 2516117
references: J Antimicrob Chemother. 2007 Apr;59(4):587-90
references: 17307768
references: Biomaterials. 2010 Feb;31(4):706-13
references: 19879645
references: ASAIO J. 2000 Nov-Dec;46(6):S47-52
references: 11110294
references: N Engl J Med. 2003 Feb 13;348(7):651-6
references: 12584377
references: Acta Biomater. 2010 Jun;6(6):2352-62
references: 20005310
references: Crit Care Med. 2004 Oct;32(10):2014-20
references: 15483409
references: J Hosp Infect. 2005 Mar;59(3):205-14
references: 15694977
references: Int J Nanomedicine. 2012;7:2767-81
references: 22745541