title: Haplotype Based Association Study between t-PA Gene and Essential Hypertension.
abstract: Several previous studies have shown that essential hypertension (EH) is associated with fibrinolysis. Tissue plasminogen activator (t-PA) plays a key role in fibrinolysis. Thus, it is possible that the t-PA gene is a susceptibility gene of EH. However, there have been no reported studies of association between EH and the t-PA gene using single nucleotide polymorphisms (SNPs). The aim of the present haplotype-based case-control study was to investigate whether SNPs in the human t-PA gene are associated with EH. We performed a genetic association study using 3 SNPs (rs7007329, rs8178750, rs4471024). The subjects were 276 EH patients and 283 age-matched normotensive (NT) individuals. There were no significant differences in overall distribution of genotypes or alleles between EH patients and NT subjects. Also, there were no significant differences in the haplotype-based case-control study. The present results do not indicate an association between the t-PA gene and EH.
authors.affiliation: Division of Receptor Biology, Advanced Medical Research Center, Nihon University School of Medicine, Japan; ; Department of Biotechnology and Applied Chemistry, Toyo University Graduate School of Engineering, Japan;
authors.forename: Kosuke
authors.initials: K
authors.lastname: Saito
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakayama
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Sato
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sato
authors.forename: Akihiko
authors.initials: A
authors.lastname: Morita
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Takahashi
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Soma
authors.forename: Ron
authors.initials: R
authors.lastname: Usami
keywords: association study; essential hypertension; genetic; haplotype; single nucleotide polymorphism; tissue plasminogen activator