title: Five new sesquiterpene lactones from Inula hupehensis.
abstract: Four new pseudoguaianolides (1-4), one new guaianolide (5), together with ten known compounds (6-15) were isolated from the aerial parts of Inula hupehensis. Their structures were elucidated mainly on the basis of 1D and 2D spectroscopic methods and circular dichroism analysis. In addition, compounds 1-10 and 13 were tested for their inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Compounds 2, 6, 8 and 9 exhibited significant inhibitory activities with IC50 values in the range of 0.6-6.6 μM.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai Dongchuan Rd 800, Shanghai, 200240, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.forename: Jiang Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Xiang Rong
authors.initials: XR
authors.lastname: Cheng
authors.forename: Shi Kai
authors.initials: SK
authors.lastname: Yan
authors.forename: Hui Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Wei Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D038143:Inula / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D035261:Plant Components, Aerial / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D007783:Lactones; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D009569:Nitric Oxide