title: Trace amount Cu (ppm)-catalyzed intramolecular cyclization of 2-(gem-dibromovinyl)phenols(thiophenols) to 2-bromobenzofurans(thiophenes).
abstract: An intramolecular cyclization of 2-(gem-dibromovinyl)phenols(thiophenols) to give 2-bromobenzofurans(thiophenes) in the presence of a trace amount of Cu (0.0064 mol%, 25 ppm) has been developed. The reaction provides the desired products in excellent yields under fluoride-free and mild reaction conditions and with a TON (turnover number) of up to 1.5 × 10(4).
authors.affiliation: Department of Chemistry, Anhui Agricultural University, Hefei, Anhui 230036, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ji
authors.forename: Pinhua
authors.initials: P
authors.lastname: Li
authors.forename: Xiuli
authors.initials: X
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010636:Phenols; D013438:Sulfhydryl Compounds; D013876:Thiophenes; D003300:Copper; C042983:thiophenol