title: Patients with neuromyelitis optica have a more severe disease than patients with relapsingremitting multiple sclerosis, including higher risk of dying of a demyelinating disease.
abstract: Although neuromyelitis optica (NMO) is known to be a more severe disease than relapsing-remitting multiple sclerosis (RRMS), few studies comparing both conditions in a single center have been done.
  
  
  METHODS
  Comparison of our previously published cohort of 41 NMO patients with 177 RRMS patients followed in the same center, from 1994 to 2007.
  
  
  RESULTS
  Mean age of onset was 32.6 for NMO and 30.2 for RRMS (p=0.2062) with mean disease duration of 7.4 years for NMO and 10.3 years for RRMS. Patients with NMO had a higher annualized relapse rate (1.0 versus 0.8, p=0.0013) and progression index (0.9 versus 0.6, p<0.0001), with more patients reaching expanded disability status scale (EDSS) 6.0 (39 versus 17%, p=0.0036). The odds ratio for reaching EDSS 6.0 and being deceased due to NMO in comparison to RRMS were, respectively, 3.14 and 12.15.
  
  
  CONCLUSIONS
  Patients with NMO have a more severe disease than patients with RRMS, including higher risk of dying of a demyelinating disease.
authors.affiliation: Setor de Neuroimunologia, Universidade Federal de São Paulo (UNIFESP), São Paulo SP, Brazil. bichuetti@unifesp.br
authors.forename: Denis Bernardi
authors.initials: DB
authors.lastname: Bichuetti
authors.forename: Enedina Maria Lobato de
authors.initials: EM
authors.lastname: Oliveira
authors.forename: Nilton Amorin de
authors.initials: NA
authors.lastname: Souza
authors.forename: Mar
authors.initials: M
authors.lastname: Tintoré
authors.forename: Alberto Alain
authors.initials: AA
authors.lastname: Gabbai
mesh_terms: D000328:Adult; D017668:Age of Onset; D018450:Disease Progression; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000401:mortality / Q000473:pathology / Q000503:physiopathology; D009471:Neuromyelitis Optica / Q000401:mortality / Q000473:pathology / Q000503:physiopathology; D012008:Recurrence; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D055815:Young Adult