title: Antibacterial and hemocompatibility switchable polypropylene nonwoven fabric membrane surface.
abstract: In this article, a facile approach to fabricate a biofunctional polypropylene nonwoven fabric membrane (PP NWF) with a switchable surface from antibacterial property to hemocompatibility is presented. In the first step, a cationic carboxybetaine ester monomer, [(2-(methacryboxy) ethyl)]-N,N-dimethylamino-ethylammonium bromide, methyl ester (CABA-1-ester) was synthesized. Subsequently, this monomer was introduced on the PP NWF surface via plasma pretreatment and a UV-induced graft polymerization technique. Finally, a switchable surface from antibacterial property to hemocompatibility was easily realized by hydrolysis of poly(CABA-1-ester) moieties on the PP NWF surface under mild conditions. Surface hydrolysis behaviors under different pH conditions were investigated. These PP NWFs grafted with poly(CABA-1-ester) segments can cause significant suppression of S. aureus proliferation; after hydrolysis, these surfaces covered by poly[(2-(methacryloxy) ethyl)] carboxybetaine (poly(CABA)) chains exhibited obvious reduction in protein adsorption and platelet adhesion, and remarkably enhanced antithrombotic properties. This strategy demonstrated that a switchable PP NWF surface from antibacterial property to hemocompatibility was easily developed by plasma pretreatment and UV-induced surface graft polymerization and that this surface may become an attractive platform for a range of biomedical applications.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P R China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Lingjie
authors.initials: L
authors.lastname: Song
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shi
authors.forename: Shifang
authors.initials: S
authors.lastname: Luan
authors.forename: Jinghua
authors.initials: J
authors.lastname: Yin
mesh_terms: D000327:Adsorption; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001622:Betaine / Q000737:chemistry; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D001798:Blood Proteins / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D005343:Fibrinolytic Agents / Q000737:chemistry; D006868:Hydrolysis; D008422:Materials Testing / Q000379:methods*; D008567:Membranes, Artificial; D008956:Models, Chemical; D010973:Platelet Adhesiveness / Q000187:drug effects; D011109:Polymethacrylic Acids / Q000737:chemistry; D011126:Polypropylenes / Q000737:chemistry*; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000187:drug effects*; D014466:Ultraviolet Rays
chemical_list: D000900:Anti-Bacterial Agents; D001798:Blood Proteins; D020099:Coated Materials, Biocompatible; D005343:Fibrinolytic Agents; D008567:Membranes, Artificial; D011109:Polymethacrylic Acids; D011126:Polypropylenes; C517178:polycarboxybetaine methacrylate; D001622:Betaine