title: Enteropathic spondyloarthritis: from diagnosis to treatment.
abstract: Enteropathic arthritis (EA) is a spondyloarthritis (SpA) which occurs in patients with inflammatory bowel diseases (IBDs) and other gastrointestinal diseases. Diagnosis is generally established on the medical history and physical examination. It was, generally, made according to the European Spondyloarthropathy Study Group (ESSG) criteria. Rheumatic manifestations are the most frequent extraintestinal findings of IBD with a prevalence between 17% and 39%, and IBD is associated, less frequently, with other rheumatic disease such as rheumatoid arthritis, Sjogren syndrome, Takayasu arteritis, and fibromyalgia. Although the pathogenesis of EA has not been plainly clarified, the most popular theory supposes that joint inflammation occurs in genetically predisposed subjects with bacterial gut infections, provided an important evidence for a possible relationship between inflammation of the gut mucosa and arthritis. The management of patients with EA requires an active cooperation between the gastroenterologist and rheumatologist.
authors.affiliation: Rheumatology Research Unit, University Federico II, 80131 Naples, Italy. rosario.peluso2@unina.it
authors.forename: Rosario
authors.initials: R
authors.lastname: Peluso
authors.forename: Matteo Nicola Dario
authors.initials: MN
authors.lastname: Di Minno
authors.forename: Salvatore
authors.initials: S
authors.lastname: Iervolino
authors.forename: Francesco
authors.initials: F
authors.lastname: Manguso
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Tramontano
authors.forename: Pasquale
authors.initials: P
authors.lastname: Ambrosino
authors.forename: Carmela
authors.initials: C
authors.lastname: Esposito
authors.forename: Antonella
authors.initials: A
authors.lastname: Scalera
authors.forename: Fabiana
authors.initials: F
authors.lastname: Castiglione
authors.forename: Raffaele
authors.initials: R
authors.lastname: Scarpa
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000276:immunology / Q000473:pathology*; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D015796:HLA-B27 Antigen / Q000235:genetics / Q000276:immunology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000276:immunology / Q000473:pathology*; D007596:Joints / Q000187:drug effects / Q000276:immunology / Q000473:pathology*; D025241:Spondylarthritis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D015796:HLA-B27 Antigen