title: The genomics of selection in dogs and the parallel evolution between dogs and humans.
abstract: The genetic bases of demographic changes and artificial selection underlying domestication are of great interest in evolutionary biology. Here we perform whole-genome sequencing of multiple grey wolves, Chinese indigenous dogs and dogs of diverse breeds. Demographic analysis show that the split between wolves and Chinese indigenous dogs occurred 32,000 years ago and that the subsequent bottlenecks were mild. Therefore, dogs may have been under human selection over a much longer time than previously concluded, based on molecular data, perhaps by initially scavenging with humans. Population genetic analysis identifies a list of genes under positive selection during domestication, which overlaps extensively with the corresponding list of positively selected genes in humans. Parallel evolution is most apparent in genes for digestion and metabolism, neurological process and cancer. Our study, for the first time, draws together humans and dogs in their recent genomic evolution.
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, No. 32 Jiaochang Donglu, Kunming 650223, China.
authors.forename: Guo-dong
authors.initials: GD
authors.lastname: Wang
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhai
authors.forename: He-chuan
authors.initials: HC
authors.lastname: Yang
authors.forename: Ruo-xi
authors.initials: RX
authors.lastname: Fan
authors.forename: Xue
authors.initials: X
authors.lastname: Cao
authors.forename: Li
authors.initials: L
authors.lastname: Zhong
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
authors.forename: Lu-guang
authors.initials: LG
authors.lastname: Cheng
authors.forename: Andrei D
authors.initials: AD
authors.lastname: Poyarkov
authors.forename: Nikolai A
authors.initials: NA
authors.lastname: Poyarkov
authors.forename: Shu-sheng
authors.initials: SS
authors.lastname: Tang
authors.forename: Wen-ming
authors.initials: WM
authors.lastname: Zhao
authors.forename: Yun
authors.initials: Y
authors.lastname: Gao
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Lv
authors.forename: David M
authors.initials: DM
authors.lastname: Irwin
authors.forename: Peter
authors.initials: P
authors.lastname: Savolainen
authors.forename: Chung-I
authors.initials: CI
authors.lastname: Wu
authors.forename: Ya-ping
authors.initials: YP
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000235:genetics; D002681:China; D004285:Dogs / Q000235:genetics*; D019143:Evolution, Molecular; D063990:Gene Ontology; D056726:Genetic Association Studies; D014644:Genetic Variation; D005828:Genetics, Population; D023281:Genomics; D005843:Geography; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D011157:Population Dynamics; D025341:Principal Component Analysis; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D019596:Wolves / Q000235:genetics