title: Naming outcome after left or right temporal lobectomy in patients with bilateral language representation by Wada testing.
abstract: OBJECTIVE
  This study aimed to examine language outcome after left or right anterior temporal lobectomy (ATL) in patients with epilepsy with bilateral language representation on intracarotid sodium amobarbital (Wada) testing.
  
  
  METHODS
  Twenty-two patients with epilepsy with bilateral language (Wada laterality index between -50 and 50) underwent right ATL (RATL, n=10) or left ATL (LATL, n=12). All the patients were administered the Boston Naming Test preoperatively and six months postoperatively.
  
  
  RESULTS
  Left anterior temporal lobectomy patients showed greater postoperative naming decline than RATL patients. Group differences were also observed on subtests of the Wada test. Performance on the Wada naming and comprehension subtests was better in the nonsurgical hemisphere than in the surgical hemisphere in the RATL group, but there was no difference between the nonsurgical and the surgical hemisphere naming and comprehension performance in the LATL group.
  
  
  CONCLUSIONS
  Left anterior temporal lobectomy patients with bilateral language are at greater risk for naming decline than RATL patients with bilateral language. This difference may be due to relatively better naming and comprehension abilities in the nonsurgical hemisphere in the RATL group.
authors.affiliation: Department of Neurology and Comprehensive Epilepsy Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA. jjanecek@mcw.edu
authors.forename: Julie K
authors.initials: JK
authors.lastname: Janecek
authors.forename: F Scott
authors.initials: FS
authors.lastname: Winstanley
authors.forename: David S
authors.initials: DS
authors.lastname: Sabsevitz
authors.forename: Manoj
authors.initials: M
authors.lastname: Raghavan
authors.forename: Wade
authors.initials: W
authors.lastname: Mueller
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Binder
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Swanson
mesh_terms: D000328:Adult; D000654:Amobarbital / Q000008:administration & dosage; D038481:Anterior Temporal Lobectomy / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000601:surgery; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007806:Language Disorders / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D007807:Language Tests; D008297:Male; D008875:Middle Aged; D009275:Names; D009483:Neuropsychological Tests; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000654:Amobarbital