title: Adenosine stress thallium-201 myocardial perfusion imaging for detecting coronary artery disease at an early stage.
abstract: The aims of this study were to evaluate the diagnostic value of adenosine thallium-201 myocardial perfusion imaging and to compare it with exercise stress thallium-201 myocardial perfusion imaging for detecting coronary artery disease (CAD) at an early stage. Forty-one patients suspected with CAD were randomly divided into two groups. In Group 1 (n=21) adenosine stress was undertaken; the exercise stress myocardial perfusion imaging was performed in Group 2 (n=20). Coronary angiography (CAG) was performed in each patient within 2 weeks before or after single photon emission computed tomography (SPECT). Adenosine stress group vs. exercise stress group, the sensitivity was 92.86% vs. 100.0%, specificity 57.14% vs. 60.0%, positive predictive value 81.25% vs. 71.43%, negative predictive value 80.0% vs. 100.0%, accuracy 80.95% vs. 80.0% respectively. Detection rates of vessels of coronary artery lesions were 66.67% in Group 1 and 72.22% in Group 2 (P> 0.05). The side effects were mild and transient. Our results demonstrated that adenosine stress myocardial perfusion imaging is a safe and reliable diagnostic method for an early stage of CAD. As a comparative sensitivity and accuracy with exercise stress thallium-201 myocardial perfusion imaging, adenosine stress testing may provide a feasible alternative pharmacological stress method in myocardial SPECT for detection of CAD.
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital, Xiamen University, Xiamen, Fujian, China.
authors.forename: Gui-Bing
authors.initials: GB
authors.lastname: Chen
authors.forename: Hua
authors.initials: H
authors.lastname: Wu
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: He
authors.forename: Jin-Xiong
authors.initials: JX
authors.lastname: Huang
authors.forename: Dan
authors.initials: D
authors.lastname: Yu
authors.forename: Wei-Yi
authors.initials: WY
authors.lastname: Xu
authors.forename: Hao
authors.initials: H
authors.lastname: Yu
mesh_terms: D000241:Adenosine / Q000009:adverse effects; D000368:Aged; D001794:Blood Pressure; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005080:Exercise Test / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes / Q000009:adverse effects
chemical_list: D013794:Thallium Radioisotopes; D000241:Adenosine