title: Photosensitivity in the elderly-think of late-onset protoporphyria.
abstract: Photosensitivity is the clinical hallmark of both erythropoietic protoporphyria (EPP) and X-linked dominant protoporphyria (XLDPP). Both disorders result from a hereditary dysfunction in heme biosynthesis. Disease onset is usually in early childhood. However, rare patients with late-onset EPP in association with a myeloproliferative disorder or myelodysplastic syndrome have been reported. In this issue, Livideanu et al. describe the first patient with late-onset XLDPP.
authors.affiliation: Department of Dermatology, Heinrich Heine University Duesseldorf, Duesseldorf, Germany. jorge.frank@med.uni-duesseldorf.de
authors.forename: Jorge
authors.initials: J
authors.lastname: Frank
authors.forename: Pamela
authors.initials: P
authors.lastname: Poblete-Gutiérrez
authors.forename: Norbert J
authors.initials: NJ
authors.lastname: Neumann
mesh_terms: D000624:5-Aminolevulinate Synthetase / Q000172:deficiency / Q000235:genetics*; D005260:Female; D040181:Genetic Diseases, X-Linked / Q000235:genetics*; D006801:Humans; D008297:Male; D010787:Photosensitivity Disorders / Q000235:genetics*; D046351:Protoporphyria, Erythropoietic / Q000235:genetics*
chemical_list: D000624:5-Aminolevulinate Synthetase; C480079:ALAS2 protein, human