title: Serum bilirubin as a prognostic marker in patients with acute decompensated heart failure.
abstract: OBJECTIVE
  Several prognostic markers for heart failure (HF) have been determined but the importance of liver function tests (LFTs) remains unknown. The aim of this study was to determine the prognostic significance, if any, of abnormal LFTs in acute decompensated HF.
  
  
  METHODS
  All adult patients (> 18 years of age) who were admitted to a community hospital with a diagnosis of acute decompensated HF during the period January 2008 to December 2009 were identified. Exclusion criteria included acute coronary syndrome, active hepatobiliary disease, renal failure (serum creatinine ≥ 2 mg/dL), and malignancy. The primary end point was readmission secondary to acute exacerbation of HF. The Cox proportional hazard model was used for statistical analyses.
  
  
  RESULTS
  Univariate analysis showed that serum total bilirubin (TB, p < 0.01), serum B-type natriuretic peptide (p < 0.05), ejection fraction (EF, p < 0.05), and heart rate (p < 0.05) were significant predictors of hospital readmission secondary to acute decompensated HF. Multivariate analysis showed that high serum TB (> 1.3 mg/dL) on admission was an independent predictor (p < 0.05) of hospital readmission secondary to HF. The 'at-risk' group-patients with serum TB > 1.3 mg/dL and/or EF < 35% on admission-had a readmission rate that was 87% ± 20% (p < 0.05) higher than those with neither criterion.
  
  
  CONCLUSIONS
  In patients with acute decompensated HF, elevated serum TB on admission with or without low EF (< 35%) predicts a worse prognosis and early future readmission, secondary to HF.
authors.affiliation: Department of Internal Medicine, Wright Center for Graduate Medical Education, Scranton, PA, USA. jk_chintanaboina@ yahoo.com
authors.forename: Jayakrishna
authors.initials: J
authors.lastname: Chintanaboina
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Haner
authors.forename: Arjinder
authors.initials: A
authors.lastname: Sethi
authors.forename: Nimesh
authors.initials: N
authors.lastname: Patel
authors.forename: Walid
authors.initials: W
authors.lastname: Tanyous
authors.forename: Alexander
authors.initials: A
authors.lastname: Lalos
authors.forename: Samir
authors.initials: S
authors.lastname: Pancholy
authors.forename: Sameer
authors.initials: S
authors.lastname: Pancholy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001663:Bilirubin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D053208:Kaplan-Meier Estimate; D008111:Liver Function Tests; D008297:Male; D010359:Patient Readmission / Q000706:statistics & numerical data; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D001663:Bilirubin
keywords: Bilirubin; Heart failure; Liver; Prognosis