title: Use of optical imaging to progress novel therapeutics to the clinic.
abstract: There is an undisputed need for employment and improvement of robust technology for real-time analyses of therapeutic delivery and responses in clinical translation of gene and cell therapies. Over the past decade, optical imaging has become the in vivo imaging modality of choice for many preclinical laboratories due to its efficiency, practicality and affordability, while more recently, the clinical potential for this technology is becoming apparent. This review provides an update on the current state of the art in in vivo optical imaging and discusses this rapidly improving technology in the context of it representing a translation enabler or indeed a future clinical imaging modality in its own right.
authors.affiliation: Cork Cancer Research Centre, BioScience Institute, University College Cork, Cork, Ireland.
authors.forename: William L
authors.initials: WL
authors.lastname: Byrne
authors.forename: Alexandra
authors.initials: A
authors.lastname: DeLille
authors.forename: Chaincy
authors.initials: C
authors.lastname: Kuo
authors.forename: Johannes S
authors.initials: JS
authors.lastname: de Jong
authors.forename: Gooitzen M
authors.initials: GM
authors.lastname: van Dam
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Francis
authors.forename: Mark
authors.initials: M
authors.lastname: Tangney
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000295:instrumentation / Q000379:methods; D055808:Drug Discovery / Q000295:instrumentation / Q000379:methods; D005456:Fluorescent Dyes / Q000032:analysis; D015316:Genetic Therapy / Q000295:instrumentation / Q000379:methods; D006801:Humans; D061848:Optical Imaging / Q000295:instrumentation / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes
keywords: Cell therapy; Gene therapy