title: [Molecular diagnostics in pathology].
abstract: Tissue-based molecular diagnostics is a fast growing diagnostic field, which already complements morphologic classifications in many cases. Pathology based molecular diagnosis is performed almost exclusively on paraffin embedded material and always in conjunction with histopathology. Besides the classic field of tissue based detection of pathogenic organisms such as bacteria, viruses and fungi, molecular diagnostics of tumor tissue is one of the current hot topics in oncology. In this context the detection of predictive molecular biomarkers, such as specific mutations, allows patient stratification for individually tailored treatment strategies and thereby is one of the key components of individualized patient care in oncology. The rapidly growing number of clinically relevant predictive biomarkers together with impressive technical advances, specifically the development of massive parallel sequencing, will modify the care of patients with malignant diseases. Pathology, therefore, has returned in the very center of interdisciplinary patient care.
authors.affiliation: Institut für Pathologie, Universitätsklinikum Heidelberg.
authors.forename: A
authors.initials: A
authors.lastname: Stenzinger
authors.forename: R
authors.initials: R
authors.lastname: Penzel
authors.forename: V
authors.initials: V
authors.lastname: Endris
authors.forename: W
authors.initials: W
authors.lastname: Weichert
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D002869:Chromosome Aberrations; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000379:methods* / Q000639:trends*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D016612:Paraffin Embedding; D057089:Pathology, Molecular / Q000379:methods* / Q000639:trends*; D011379:Prognosis; D017422:Sequence Analysis, DNA / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor