title: Diagnosing chronic rhinosinusitis: comparing questionnaire-based and clinical-based diagnosis.
abstract: BACKGROUND
  The European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) incorporates symptomatic and endo- scopic criteria in the clinical diagnosis of chronic rhinosinusitis (CRS), while in epidemiological studies the definition is based on symptoms only. The aim of this study was to evaluate the correlation between questionnaire-based and clinical-based CRS.
  
  
  METHODS
  Based on the GA2LEN postal survey data a total of 366 persons participated at the follow-up at the Danish centre and provided information on questionnaire-based CRS. At the same occasion the 366 participants underwent clinical inter- view and examination by an otorhinolaryngologist to provide information for a clinical-based CRS diagnosis. The association between questionnaire-based and clinical-based CRS diagnosis was determined using logistic regression models and kappa statistics.
  
  
  RESULTS
  Mean age of respondents to the postal questionnaire was 45.3 years and 52.9% were female. Persons with asthma were 8.4 % and 26.2 % were actual smokers. There was moderate agreement between questionnaire-based and clinical-based CRS. Sensitivity was [corrected] low comparing questionnaire-based CRS with clinical-based CRS. Incorporation of self reported CRS and medical history in diagnosing CRS by questionnaire increased increased [corrected] the agreement and sensitivity while specificity stayed at a high level. [corrected]
  
  
  CONCLUSIONS
  Evaluating the correlation between questionnaire-based and clinical-based CRS showed only moderate agree- ment and questions whether they evaluate the same disease. It brings into consideration that adjustments are needed to justify correlation between questionnaire-based and clinical-based diagnosis of CRS.
authors.affiliation: Department of Otorhinolaryngology, University of Southern Denmark, Odense, Denmark. Bibi.lange@ouh.regionsyddanmark.dk
authors.forename: B
authors.initials: B
authors.lastname: Lange
authors.forename: T
authors.initials: T
authors.lastname: Thilsing
authors.forename: J
authors.initials: J
authors.lastname: Baelum
authors.forename: R
authors.initials: R
authors.lastname: Holst
authors.forename: A
authors.initials: A
authors.lastname: Kjeldsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003718:Denmark; D003937:Diagnosis, Differential; D004724:Endoscopy; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012220:Rhinitis / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D012852:Sinusitis / Q000175:diagnosis*; D011795:Surveys and Questionnaires