title: Association between NFKB1 -94 insertion/deletion ATTG polymorphism and risk of intracranial aneurysm.
abstract: OBJECTIVE
  Growing evidence indicates that vascular inflammation is a common phenomenon in the pathogenesis of intracranial aneurysms (IAs). Nuclear factor kappa B is a key molecule that is involved in the vascular inflammation of IA. We hypothesized that an insertion/deletion (ins/del) ATTG polymorphism located between two putative key promoter regulatory elements in the NFKB1 gene may be related to the risk of IA.
  
  
  METHODS
  We performed a case-control study, including 164 patients with IA and 525 healthy controls in a Chinese population using a polymerase chain reaction-polyacrylamide gel electrophoresis assay.
  
  
  RESULTS
  A significantly decreased risk of IA was observed in the ATTG1/ATTG2 and ATTG2/ATTG2 genotypes compared with the ATTG1/ATTG1 genotype (ATTG1/ATTG2 vs. ATTG1/ATTG1: odds ratio [OR]=0.58, 95% confidence interval [95% CI]=0.39-0.87, p=0.007; ATTG2/ATTG2 vs. ATTG1/ATTG1: OR=0.12, 95% CI=0.06-0.23, p<0.001), and also the ATTG2 allele (ATTG2 vs. ATTG1: OR=0.41, 95% CI=0.32-0.54, p<0.001).
  
  
  CONCLUSIONS
  These findings suggest that the NFKB1 -94ins/del ATTG polymorphism may contribute to the risk of IA.
authors.affiliation: Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, People's Republic of China.
authors.forename: Xiutian
authors.initials: X
authors.lastname: Sima
authors.forename: Jianguo
authors.initials: J
authors.lastname: Xu
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: You
mesh_terms: D000328:Adult; D001483:Base Sequence / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D054643:INDEL Mutation; D002532:Intracranial Aneurysm / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D011110:Polymorphism, Genetic; D020218:Response Elements / Q000235:genetics*; D012307:Risk Factors
chemical_list: D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human