title: [Clinical characteristics and antibiotic resistance in children with invasive Acinetobacter baumannii infection].
abstract: OBJECTIVE
  To analyze the clinical characteristics and antibiotic resistance in children with invasive Acinetobacter baumannii infection (IABI).
  
  
  METHODS
  A retrospective analysis was performed on the clinical and drug sensitivity data of 52 children with IABI between January 2004 and December 2011.
  
  
  RESULTS
  Of the 52 children with IABI, 35 (67%) were less than one year old and 35 (67%) had IABI in the summer and autumn, 19 (37%) of these children were clinically diagnosed with septicemia, 16 (31%) with urinary tract infection, and 12 (23%) with skin and soft tissue infection, and 38 (73%) of them suffered from underlying diseases. The incidence rates of hospital-acquired and community-acquired IABIs were 90% and 10% respectively; 44 cases (85%) were cured or showed improvement in symptoms, and 8 cases (15%) died. All the IAB strains isolated from these children were sensitive to amikacin, 82% of them were sensitive to imipenem, more than 70% were sensitive to fluoroquinolone and to cefoperazone/sulbactam, 13% were sensitive to cefoperazone, 8% were sensitive to aztreonam, 21% developed multidrug resistance, and 17% developed pan-drug resistance.
  
  
  CONCLUSIONS
  IABI occurs more frequently in children under one year of age, and most children with IABI have underlying diseases. IABI mainly results in septicemia, urinary tract infection and skin and soft tissue infection and is mostly hospital-acquired. Multi-drug resistance and pan-drug resistance are severe in IAB strains.
authors.affiliation: Department of Respiratory Medicine, Yuying Children's Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang 325027, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Dong
authors.forename: Yue-Bo
authors.initials: YB
authors.lastname: Xu
authors.forename: Zhao-Xing
authors.initials: ZX
authors.lastname: Chen
authors.forename: Jie-Min
authors.initials: JM
authors.lastname: Fan
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy*; D040981:Acinetobacter baumannii; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies