title: Long term clinical outcomes in DES implantation for unprotected left main disease.
abstract: OBJECTIVE
  Generate a long term follow-up and evaluate the impact of clinical and procedural characteristics on long term events in percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation for unprotected left main coronary artery (ULMCA) disease.
  
  
  METHODS
  Ninety-seven consecutive patients who underwent PCI with DES, either sirolimus (SES) or paclitaxel-eluting stent (PES), for de novo lesions in ULMCA were analyzed. No patients were excluded. Mean follow-up was 3 years (range 1-6.7 years).
  
  
  RESULTS
  Technical and procedural success rate were 100% and 95.9%. According to the Academic Research Consortium definitions, cardiac death occurred in 6.1% of patients, reinfarction, target vessel revascularization (TVR) and target lesion revascularization (TLR) occurred in 6.1%, 17.5% and 4.2% of patients respectively. Definite stent thrombosis (ST) incidence was 1%, whereas possible ST occurred in 4.2% of patients. Postdilation was performed in 49.5% of patients and was, among all clinical and procedural characteristics, the only factor at multivariate analysis significantly related to lower MACE (25% vs. 46.9%, P=0.024, CI: 0.202 to 0.889) and TVR (8.3% vs. 26.5%, P=0.03 CI: 0.096-0.895).
  
  
  CONCLUSIONS
  Long term follow-up in PCI of ULMCA disease shows favorable clinical results. Stent postdilation seems to have a protective role in DES PCI for ULMCA disease.
authors.affiliation: San Giovanni Battista Molinette Hospital, Turin, Italy. federico.conrotto@gmail.com
authors.forename: F
authors.initials: F
authors.lastname: Conrotto
authors.forename: M
authors.initials: M
authors.lastname: D'amico
authors.forename: E
authors.initials: E
authors.lastname: Ebrille
authors.forename: P
authors.initials: P
authors.lastname: Scacciatella
authors.forename: M
authors.initials: M
authors.lastname: Pennone
authors.forename: E
authors.initials: E
authors.lastname: Meliga
authors.forename: S
authors.initials: S
authors.lastname: Marra
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D003324:Coronary Artery Disease / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods; D019919:Prosthesis Implantation; D012008:Recurrence; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome