title: Chemotherapy-induced prospective memory impairment in patients with breast cancer.
abstract: OBJECTIVE
  This study aimed to investigate the event-based prospective memory (EBPM) and time-based prospective memory (TBPM) in chemotherapy-induced cognitive impairment in patients with breast cancer.
  
  
  METHODS
  Forty patients with breast cancer who underwent adjuvant chemotherapy and 40 age-matched and education-matched healthy women were administered with a battery of neuropsychological tests including EBPM and TBPM tasks.
  
  
  RESULTS
  A significant difference between breast cancer patients and controls was found in the scores on the mini-mental state examination (t = -11.684, p < 0.01), verbal fluency test (t = -7.939, p < 0.01), and digit span (t = -2.538, p < 0.05). Compared with healthy controls, breast cancer patients exhibited a poorer performance on EBPM (t = -7.096, p < 0.01) but not on TBPM (t = -1.921, p > 0.05).
  
  
  CONCLUSIONS
  Our results suggest that breast cancer patients who had undergone adjuvant chemotherapy show deficits in EBPM but not in TBPM.
authors.affiliation: Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Huaidong
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Dong
authors.affiliation: Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Chanjuan
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Mingjun
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Zhonglian
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Neuropsychological Laboratory, Institute of Neurology and Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000523:psychology*; D016022:Case-Control Studies; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D003072:Cognition Disorders / Q000139:chemically induced / Q000523:psychology*; D005260:Female; D006801:Humans; D008569:Memory Disorders / Q000139:chemically induced / Q000523:psychology*; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests
chemical_list: D000970:Antineoplastic Agents
keywords: cancer; chemotherapy; cognitive; oncology; prospective memory