title: Dissemination of the KPC-2 carbapenemase in non-Klebsiella pneumoniae enterobacterial isolates from Colombia.
abstract: Klebsiella pneumoniae carbapenemase (KPC)-type enzymes have largely disseminated worldwide among K. pneumoniae isolates. In this study, 11 non-K. pneumoniae KPC-producing enterobacterial isolates from four hospitals located in different Colombian cities were genetically investigated. All isolates were multidrug-resistant and harboured the bla(KPC-2) gene along with several other acquired β-lactamase genes. The bla(KPC-2) gene was associated with transposon Tn4401b inserted in different loci of plasmids varying in size and replicon type. The presence of KPC-2 in different enterobacterial species from different cities within Colombia underlines the spread of KPC beyond K. pneumoniae.
authors.affiliation: Service de Bactériologie-Virologie, INSERM U914: 'Emerging Resistance to Antibiotics', Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, 94275 Le Kremlin-Bicêtre, Faculté de Médecine Paris-Sud, France.
authors.forename: Gaelle
authors.initials: G
authors.lastname: Cuzon
authors.forename: Thierry
authors.initials: T
authors.lastname: Naas
authors.forename: Adriana
authors.initials: A
authors.lastname: Correa
authors.forename: John P
authors.initials: JP
authors.lastname: Quinn
authors.forename: Maria-Virginia
authors.initials: MV
authors.lastname: Villegas
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D003105:Colombia / Q000453:epidemiology; D004251:DNA Transposable Elements; D024901:Drug Resistance, Multiple, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology; D056426:Genetic Loci; D006761:Hospitals; D006801:Humans; D017720:Molecular Epidemiology; D015995:Prevalence; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases