title: New bioactive secondary metabolites from Bornean red alga, Laurencia similis (Ceramiales).
abstract: A Bomean red algal population of Laurencia similis Nam et Saito was analyzed for its secondary metabolite composition. Seven compounds were identified: ent-1(10)-aristolen-9beta-ol (1), (+)-aristolone (2), axinysone B (3), 9-aristolen-1alpha-ol (4), 2,3,5,6-tetrabromoindole (5), 1-methyl-2,3,5,6-tetrabromoindole (6), and 1-methyl-2,3,5-tribromoindole (7). Compound 1 was identified as a new optical isomer of 1(10)-aristolen-9beta-ol. Compounds 1, 4 and 5 exhibited good antibacterial activity against antibiotic resistant clinical bacteria and cytotoxic effects against selected cancer cell lines.
authors.affiliation: Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kamada
authors.forename: Charles Santhanaraju
authors.initials: CS
authors.lastname: Vairappan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D044722:Laurencia / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents