title: Topical tazarotene for the treatment of ectropion in ichthyosis.
abstract: OBJECTIVE
  Ectropion is a complication of certain subtypes of ichthyosis and is often associated with substantial medical and cosmetic consequences. At present there is no standard of care for the treatment of ectropion in this population. Retinoids cause dyshesion and thinning of stratum corneum, thereby reducing hyperkeratosis that likely underlies ectropion in patients with ichthyosis. As such, retinoids provide a potential effective treatment for ectropion in this group of patients.
  
  
  METHODS
  We describe a patient with recessive ichthyosis for whom daily application of topical tazarotene produced rapid and persistent improvement of bilateral lower eyelid ectropion without adverse effects.
  
  
  CONCLUSIONS
  Additional studies will be necessary to more fully and systematically address the safety and efficacy of topical retinoids for the treatment of ectropion in patients with ichthyosis; however, this case illustrates that topical tazarotene and other retinoids provide a potential treatment option for ectropion in this population. We encourage clinicians to explore medical therapies as alternatives to surgical intervention for the treatment of ectropion in patients with ichthyosis.
authors.affiliation: Department of Dermatology, Yale University School of Medicine, PO Box 208059, New Haven, CT 06520, USA. brittany.craiglow@yale.edu
authors.forename: Brittany G
authors.initials: BG
authors.lastname: Craiglow
authors.forename: Keith A
authors.initials: KA
authors.lastname: Choate
authors.forename: Leonard M
authors.initials: LM
authors.lastname: Milstone
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D004483:Ectropion / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000150:complications*; D007641:Keratolytic Agents / Q000008:administration & dosage*; D009539:Nicotinic Acids / Q000008:administration & dosage*; D012176:Retinoids
chemical_list: D007641:Keratolytic Agents; D009539:Nicotinic Acids; C086827:tazarotene; D012176:Retinoids