title: The maintenance of wakefulness test in pediatric narcolepsy.
abstract: Objective tools are needed to assess the response to treatment in pediatric narcolepsy. This article presents a single-center experience documenting the use of the maintenance of wakefulness test (MWT) in a pediatric series. This study reviewed the charts of children with narcolepsy who had an MWT performed between January 2008 and June 2012. A cutoff was used for mean sleep latency: <8 minutes for inadequate control of hypersomnia, and >20 minutes to indicate adequate control on medications. Thirteen tests were performed on 10 children (median age 15.8 years, range 8.7-20.3 years) with narcolepsy, of which six had cataplexy and three were boys. Comorbid conditions included Prader-Willi syndrome, bipolar affective disorder, and epilepsy (n = 1 each). The median mean sleep latency for all studies was 16 minutes (range 5.8-40 minutes). Sleep-onset rapid eye movement sleep events were seen in three of 13 studies. In seven patients, findings from the MWT resulted in changes in management. These data suggest that the MWT may be a useful and feasible test for assessing response to treatment in children with narcolepsy. Future research is needed to obtain normative MWT data on children with and without narcolepsy.
authors.affiliation: Center for Pediatric Sleep Disorders, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Zandieh
authors.forename: Sriram
authors.initials: S
authors.lastname: Ramgopal
authors.forename: Umakanth
authors.initials: U
authors.lastname: Khatwa
authors.forename: Michelle
authors.initials: M
authors.lastname: Sangiuliano
authors.forename: Michael
authors.initials: M
authors.lastname: Gunnuscio
authors.forename: Marcin
authors.initials: M
authors.lastname: Zarowski
authors.forename: Sanjeev V
authors.initials: SV
authors.lastname: Kothare
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009290:Narcolepsy / Q000503:physiopathology* / Q000523:psychology; D017286:Polysomnography; D011788:Quality of Life; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012895:Sleep, REM / Q000502:physiology*; D011795:Surveys and Questionnaires; D014851:Wakefulness / Q000502:physiology*; D055815:Young Adult