title: [Cardiac arrest caused by massive pulmonary embolism during treatment with tranexamic acid].
abstract: Pulmonary embolism (PE) as the direct cause of cardiac arrest is well known but probably under-diagnosed. Treatment of menorrhagia with antifibrinolytics is a well documented treatment modality and it is considered safe although thromboembolic complications have been reported. We describe a case of a 30-year-old otherwise healthy woman, who had been treated with antifibrinolytics for up to six months prior to the event, presenting with fatal acute, massive PE and cardiac arrest, which was treated with prompt resuscitation including thrombolysis with recombinant tissue plasminogen activator and subsequent return of spontaneous circulation.
authors.affiliation: Medicinsk Afdeling, Holbæk Sygehus, Denmark. mgybel@gmail.com
authors.forename: Mikkel
authors.initials: M
authors.lastname: Gybel
authors.forename: Kjeld
authors.initials: K
authors.lastname: Kristensen
authors.forename: Natasha
authors.initials: N
authors.lastname: Roseva-Nielsen
mesh_terms: D000208:Acute Disease; D000328:Adult; D000933:Antifibrinolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016887:Cardiopulmonary Resuscitation; D017809:Fatal Outcome; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006323:Heart Arrest / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008595:Menorrhagia / Q000188:drug therapy; D011655:Pulmonary Embolism / Q000139:chemically induced / Q000150:complications* / Q000000981:diagnostic imaging; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014148:Tranexamic Acid / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000933:Antifibrinolytic Agents; D005343:Fibrinolytic Agents; D014148:Tranexamic Acid; D010959:Tissue Plasminogen Activator