title: [Infectious properties of protein aggregates involved in neurodegenerative diseases].
abstract: Several progressive neurodegenerative disorders, e.g. Alzheimer, Parkinson and Huntington diseases, cerebro-spinal ataxia and amyotrophic lateral sclerosis, are the consequence of protein misfolding and aggregation. Recent data indicates that some of these diseases are not cell autonomous as previously thought. We and others have shown that protein assemblies involved in the aforementioned diseases propagate from cell to cell in a manner akin prion high molecular weight assemblies propagation in Creutzfeldt-Jacob disease. The mechanism of propagation and amplification of protein assemblies involved in neurodegenerative diseases and its physiopathological consequences are discussed hereafter.
authors.affiliation: Laboratoire d'Enzymologie et Biochimie Structurale, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Bousset
authors.forename: Ronald
authors.initials: R
authors.lastname: Melki
mesh_terms: D002450:Cell Communication; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D017510:Protein Folding; D055503:Protein Multimerization; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins