title: Risk factors and outcome of atypical acute post-streptococcal glomerulonephritis in pediatrics.
abstract: We conducted this study to identify the clinical features and risk factors for atypical acute post-streptococcal glomerulonephritis (APSGN). Thirty-five cases of atypical APSGN treated at Srinagarind Hospital during 2002-2009 were compared with 27 typical cases. The clinical symptoms, anti-streptococcal antibody titers, and laboratory data at the first hospital visit were compared between the two groups. A marked elevation in anti-streptolysin O (ASO) titer was seen more commonly in the atypical APSGN group than in the typical APSGN group (p=0.025). Significantly more patients in the atypical APSGN group had a high urine specific gravity, hematuria and pyuria than patients in the typical APSGN group (p<0.01, p<0.031, and p<0.046, respectively). A high ASO titer, high urine specific gravity, severe hematuria and pyuria early in the illness were suggestive of a higher risk for an atypical presentation.
authors.affiliation: Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: Satoru
authors.initials: S
authors.lastname: Takeno
authors.forename: Suwannee
authors.initials: S
authors.lastname: Wisanuyotin
authors.forename: Apichat
authors.initials: A
authors.lastname: Jiravuttipong
authors.forename: Chukiat
authors.initials: C
authors.lastname: Sirivichayakul
authors.forename: Kriengsak
authors.initials: K
authors.lastname: Limkittikul
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000453:epidemiology*; D006403:Hematologic Tests; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D012307:Risk Factors; D013290:Streptococcal Infections / Q000453:epidemiology*; D016482:Urinalysis
chemical_list: D000907:Antibodies, Bacterial; D018836:Inflammation Mediators