title: Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling.
abstract: This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response.In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery of Federal University of São Paulo, Rua Maestro Antão Fernandes, 173, Jd São Bento, São Paulo, SP02526-060, Brazil. pezatobau@ig.com.br.
authors.forename: Rogério
authors.initials: R
authors.lastname: Pezato
authors.forename: Leonardo
authors.initials: L
authors.lastname: Balsalobre
authors.forename: Milena
authors.initials: M
authors.lastname: Lima
authors.forename: Thiago F P
authors.initials: TF
authors.lastname: Bezerra
authors.forename: Richard L
authors.initials: RL
authors.lastname: Voegels
authors.forename: Luis Carlos
authors.initials: LC
authors.lastname: Gregório
authors.forename: Aldo Cassol
authors.initials: AC
authors.lastname: Stamm
authors.forename: Thibaut
authors.initials: T
authors.lastname: van Zele
mesh_terms: D056151:Airway Remodeling / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D020783:Matrix Metalloproteinase 7 / Q000502:physiology; D020780:Matrix Metalloproteinase 9 / Q000502:physiology; D009298:Nasal Polyps / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D012220:Rhinitis / Q000276:immunology / Q000382:microbiology; D012852:Sinusitis / Q000276:immunology / Q000382:microbiology; D013211:Staphylococcus aureus; D018089:Superantigens / Q000502:physiology; D053773:Transforming Growth Factor beta1 / Q000502:physiology
chemical_list: D018089:Superantigens; D053773:Transforming Growth Factor beta1; D007073:Immunoglobulin E; D020783:Matrix Metalloproteinase 7; D020780:Matrix Metalloproteinase 9