title: [Synthetic biology toward microbial secondary metabolites and pharmaceuticals].
abstract: Microbial secondary metabolites are one of the major sources of anti-bacterial, anti-fungal, antitumor, anti-virus and immunosuppressive agents for clinical use. Present challenges in microbial pharmaceutical development are the discovery of novel secondary metabolites with significant biological activities, improving the fermentation titers of industrial microbial strains, and production of natural product drugs by re-establishing their biosynthetic pathways in suitable microbial hosts. Synthetic biology, which is developed from systematic biology and metabolic engineering, provides a significant driving force for microbial pharmaceutical development. The review describes the major applications of synthetic biology in novel microbial secondary metabolite discovery, improved production of known secondary metabolites and the production of some natural drugs in genetically modified or reconstructed model microorganisms.
authors.affiliation: Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China.
authors.forename: Lin-Zhuan
authors.initials: LZ
authors.lastname: Wu
authors.forename: Bin
authors.initials: B
authors.lastname: Hong
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D001688:Biological Products / Q000378:metabolism*; D055808:Drug Discovery; D005285:Fermentation; D005658:Fungi / Q000378:metabolism*; D018014:Gene Transfer Techniques; D060847:Metabolic Engineering; D058615:Synthetic Biology
chemical_list: D001688:Biological Products