title: Interleukin-1β gene polymorphism and hearing loss related to the history of occupational noise exposure in Brazilian elderly.
abstract: Hearing loss is the most common sensory impairment in older people, and may have social and psychological consequences, such as social isolation, frustration and depression. Noise-induced hearing loss (NIHL) is an interaction of both genetic and environmental factors. Some studies have led to the identification of possible NIHL susceptibility genes. The aim of the present study was to investigate whether the polymorphism of the interleukin (IL)-1β gene at position + 3954 was associated with complaints of hearing loss due to occupational exposure. The sample was composed of elderly people with hearing loss (age ≥ 60 years) divided into two groups: 99 with occupational exposure to noise and 193 without exposure. Information on occupational exposure to noise was obtained through interviews using a semi-structured questionnaire. Hearing acuity was measured from 500 to 6000 Hz and the IL-1β genotype was obtained by the polymerase chain reaction- restriction fragment length polymorphism technique. Differences in allelic and genotypic frequencies, and the association between genotypic frequencies and complaints of hearing loss due to occupational exposure, were analyzed by the Chi-square test at the 5% significance level. Fifty-one percent of the elderly were homozygous for the ancestral allele (C), 17.2% were homozygous for the polymorphic allele (T) and 31.8% were heterozygous. The frequency was found to be 67-33% C to allele T. There was no significant association between polymorphism in gene IL-1β and hearing loss associated with occupational exposure (χ2 = 0.538; P = 0.676). No association was found with the polymorphism of the IL-1β +3954 C/T gene and hearing loss associated with the occupational noise exposure history.
authors.affiliation: Department of Molecular Biology, Centre of Research in Health Sciences, University of Northern Parana, Londrina, PR, Brazil.
authors.forename: Luiz C L
authors.initials: LC
authors.lastname: Carvalho
authors.forename: Luciana L M
authors.initials: LL
authors.lastname: Marchiori
authors.forename: Juliana J
authors.initials: JJ
authors.lastname: Melo
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Maciel
authors.forename: Regina C
authors.initials: RC
authors.lastname: Poli-Frederico
mesh_terms: D000368:Aged; D001299:Audiometry; D001938:Brazil; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006317:Hearing Loss, Noise-Induced / Q000235:genetics*; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009623:Noise, Occupational; D020641:Polymorphism, Single Nucleotide
chemical_list: C508585:IL1B protein, human; D053583:Interleukin-1beta