title: Long-term survivor of relapsed stage IV malignant rhabdoid tumor of the kidney.
abstract: The prognosis for metastatic malignant rhabdoid tumor (MRT) is poor, and metastatic (stage IV) MRT was resistant to conventional treatment, with less than 20% of cure rate. Moreover, there have been no reports of patients who have survived relapsed stage IV MRT. Here we report a long-term survivor of relapsed MRT with lung metastasis at diagnosis. He was diagnosed as MRT of the kidney at 5-month-old. After resection of the renal tumor, he was treated with ICE (ifosfamide, carboplatin, and etoposide), total abdominal irradiation 10.8 Gy and high-dose chemotherapy using thiotepa and melphalan. Six months after initial treatment, a relapse in the lung was detected, and he received chemotherapy including doxorubicin/pirarubicin for 78 weeks. He is alive at five years of follow up, without any evidence of disease. Our report suggests the important role of anthracycline in treatment of MRT.
authors.affiliation: Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan. katom-tky@umin.ac.jp
authors.forename: Motohiro
authors.initials: M
authors.lastname: Kato
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Koh
authors.forename: Koichi
authors.initials: K
authors.lastname: Oshima
authors.forename: Eiji
authors.initials: E
authors.lastname: Oguma
authors.forename: Hiroo
authors.initials: H
authors.lastname: Uchida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kishimoto
authors.forename: Akira
authors.initials: A
authors.lastname: Kikuchi
authors.forename: Ryoji
authors.initials: R
authors.lastname: Hanada
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000188:drug therapy*; D009367:Neoplasm Staging; D018335:Rhabdoid Tumor / Q000175:diagnosis* / Q000188:drug therapy; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents