title: Heat shock protein 70 and albuminuria in patients with type 2 diabetes: a matched case control study.
abstract: Here, we aimed to study serum heat shock protein (HSP) 70 levels in diabetic patients with and without albuminuria. We performed a 1:1 matched case control study on 40 diabetic patients with albuminuria as cases and 40 age, sex, body mass index matched diabetic patients without albuminuria (normoalbuminuria) as controls. Normoalbuminuria was defined as urinary albumin excretion rate <15 mg/12 h, and albuminuria was defined as urinary albumin excretion rate between 100-400 mg/12 h. Patients with albuminuria had a higher HSP70 than controls (0.83 ± 0.50 vs. 0.63 ± 0.06; p = 0.02), while they did not differ in any other studied variables. In ten of the studied pairs, the controls had higher HSP70 levels than cases (reverse relationship). Patients in the "direct relationship group" had higher HbA1c values than the patients in the "reverse relationship group" (8.9 ± 0.3 vs. 7.3 ± 0.6, p = 0.04). Cases in the reverse pairs had a lower low density lipoprotein cholesterol levels than their controls. The odds ratio of HSP70 in the prediction of albuminuria was (28.69 (3.2-250.1), p = 0.002). In conclusion, we have shown an increased HSP70 levels in diabetic patients with albuminuria.
authors.affiliation: Endocrinology and Diabetes Division, Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran, aafsaneh03@gmail.com.
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Morteza
authors.forename: Manouchehr
authors.initials: M
authors.lastname: Nakhjavani
authors.forename: Mehrdada
authors.initials: M
authors.lastname: Larry
authors.forename: Arash Aghajani
authors.initials: AA
authors.lastname: Nargesi
authors.forename: Alireza
authors.initials: A
authors.lastname: Esteghamati
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000150:complications*; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism / Q000473:pathology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio
chemical_list: D006442:Glycated Hemoglobin; D018840:HSP70 Heat-Shock Proteins; D008077:Lipoproteins, LDL