title: Genetic association between selected cytokine genes and glioblastoma in the Han Chinese population.
abstract: BACKGROUND
  Glioblastoma (GBM) is the most malignant brain tumor. Many abnormal secretion and expression of cytokines have been found in GBM, initially speculated that the occurrence of GBM may be involved in these abnormal secretion of cytokines. This study aims to detect the association of cytokine genes with GBM.
  
  
  METHODS
  We selected seven tag single nucleotide polymorphisms (tSNPs) in six cytokine genes, which previously reported to be associated with brain tumors, and analyzed their association with GBM in a Han Chinese population using χ(2) test and genetic model analysis.
  
  
  RESULTS
  We found two risk tSNPs and one protective tSNP. By χ(2) test, the rs1801275 in IL-4R showed an increased risk of GBM. In the genetic model analysis, the genotype "TC" of rs20541 in IL-13 gene showed an increased risk of GBM in over-dominant model (OR = 2.00; 95% CI, 1.13-3.54, p = 0.015); the genotype "CT" of rs1800871 in the IL-10 gene showed a decrease risk in the over-dominant model (OR = 0.57; 95% CI, 0.33 - 0.97; p = 0.037). The genotype "AG" of rs1801275 in the IL-4R gene showed an increase risk in over-dominant model (OR = 2.29; 95% CI, 1.20 - 4.35; p = 0.0081) We further analyzed whether the six cytokine genes have a different effect on the disease in gender specific population, and found that the allele "G" of rs2243248 in the IL-4 gene showed a decrease risk of GBM in female (OR = 0.35, 95% CI, 0.13 - 0.94, p = 0.0032), but the allele "T" showed a decrease risk in male (OR = 0.30, 95% CI, 0.17 - 0.53, p = 0.0032).
  
  
  CONCLUSIONS
  Our findings, combined with previously reported results, suggest that cytokine genes have potential role in GBM development, which may be useful to early prognostics for GBM in the Han Chinese population.
authors.affiliation: School of Life Sciences, Northwest University, Xi'an 710069, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Li
authors.forename: Jiayi
authors.initials: J
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Tingting
authors.initials: T
authors.lastname: Geng
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Guodong
authors.initials: G
authors.lastname: Gao
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D001932:Brain Neoplasms / Q000235:genetics*; D016009:Chi-Square Distribution; D002681:China; D016001:Confidence Intervals; D016207:Cytokines / Q000235:genetics*; D005260:Female; D005838:Genotype; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10; D018793:Interleukin-13 / Q000235:genetics; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D019948:Receptors, Interleukin-4 / Q000235:genetics; D012737:Sex Factors
chemical_list: D016207:Cytokines; D018793:Interleukin-13; D019948:Receptors, Interleukin-4; D016753:Interleukin-10