title: Surgical approach to the management of medullary thyroid cancer: when is lymph node dissection needed?
abstract: OBJECTIVE
  Medullary thyroid cancer (MTC) is a rare and particularly aggressive type of thyroid cancer of neuroendocrine origin. It occurs in hereditary and sporadic forms and its aggressiveness is related to the clinical presentation and the type of RET mutation.
  
  
  METHODS
  In this article, we present the criteria, as reviewed in contemporary literature, regarding lymph node dissection and radical neck dissection in patients with either sporadic or hereditary MTC.
  
  
  RESULTS
  Early diagnosis and treatment remains the key to a 100% cure rate.
  
  
  CONCLUSIONS
  Routine central lymph node dissection is the minimum procedure recommended for all sporadic and hereditary MTCs. Routine lateral lymph node dissection on either side is necessary when lymph node metastases are found in the central neck compartment.
authors.affiliation: Department of Surgery, General Hospital of Karditsa, Karditsa, Greece. mixalislak @ gmail.com
authors.forename: Michael
authors.initials: M
authors.lastname: Stamatakos
authors.forename: Panoraia
authors.initials: P
authors.lastname: Paraskeva
authors.forename: Paraskevas
authors.initials: P
authors.lastname: Katsaronis
authors.forename: Georgia
authors.initials: G
authors.lastname: Tasiopoulou
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Kontzoglou
mesh_terms: D018276:Carcinoma, Medullary / Q000151:congenital* / Q000556:secondary / Q000601:surgery*; D018278:Carcinoma, Neuroendocrine; D006801:Humans; D008207:Lymphatic Metastasis; D018813:Multiple Endocrine Neoplasia Type 2a / Q000601:surgery*; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D013964:Thyroid Neoplasms / Q000473:pathology / Q000601:surgery*