title: Replacement of Neisseria meningitidis C cc11/ET-15 variant by a cc103 hypervirulent clone, Brazil 2005-2011.
abstract: Outbreaks caused by serogroup C meningococci in the northeast region of Brazil from 2005 to 2011 were associated to the emergence of variant ET-15 of cc11, which has been replaced by cc103 from 2006 to date. The increase of cc103 should be closely monitored to prevent the spread of this clone to neighbouring regions.
authors.affiliation: Instituto Nacional de Controle de Qualidade em Saude - FIOCRUZ, Rio de Janeiro, Brasil.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Sardinha
authors.forename: Soraia
authors.initials: S
authors.lastname: Cordeiro
authors.forename: Erica
authors.initials: E
authors.lastname: Gomes
authors.forename: Cinthia
authors.initials: C
authors.lastname: Romanelli
authors.forename: Claudia
authors.initials: C
authors.lastname: Andrade
authors.forename: Joice
authors.initials: J
authors.lastname: Reis
authors.forename: Ivano
authors.initials: I
authors.lastname: de Filippis
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D002999:Clone Cells; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D015994:Incidence; D008585:Meningitis, Meningococcal / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D058885:Multilocus Sequence Typing; D038542:Neisseria meningitidis, Serogroup C / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D012703:Serotyping; D014774:Virulence
chemical_list: D000900:Anti-Bacterial Agents
keywords: Brazil; Hypervirulent clone; MLST; Meningococcal disease; Neisseria meningitidis C