title: Association between dopamine Beta-hydroxylase gene polymorphisms and attention-deficit hyperactivity disorder in korean children.
abstract: Attention-deficit hyperactivity disorder (ADHD) is a common disorder of the school-age population. ADHD is familial, and genetic studies estimate heritability at 80%-90%. The aim of the present study was to investigate the association between the genetic type and alleles for the dopamine beta-hydroxylase (DBH) gene in Korean children with ADHD. The sample consisted of 142 ADHD children and 139 control children. We diagnosed ADHD according to DSM-IV. ADHD symptoms were evaluated with the Conners' Parent Rating Scales and Dupaul Parent ADHD Rating Scales. Blood samples were taken from the 281 subjects; DNA was extracted from blood lymphocytes, and polymerase chain reaction was performed for the DBH polymorphism. The alleles and genotype frequencies were compared using the chi-square test. We compared the allele and genotype frequencies of the DBH gene polymorphism in the ADHD and control groups. This study showed that there was a significant correlation among the frequencies of rs1611115 (odds ratio=0.64, 95% confidence interval=0.42-0.97, p=0.034) of the alleles of DBH, but the final conclusions are not definite. Follow-up studies with larger patient or pure subgroups are expected. These results suggested that DBH might be related to ADHD symptoms.
authors.affiliation: Environmental Health Center, Dankook Medical Hospital, Cheonan, South Korea.
authors.forename: Ho Jang
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Lim
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D056910:Republic of Korea / Q000453:epidemiology
chemical_list: D004299:Dopamine beta-Hydroxylase