title: Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions.
abstract: Losing ligands rapidly: Pt(IV) complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH 7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H2(18)O and ESI-MS analysis.
authors.affiliation: Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel.
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Wexselblatt
authors.forename: Eylon
authors.initials: E
authors.lastname: Yavin
authors.forename: Dan
authors.initials: D
authors.lastname: Gibson
mesh_terms: D006868:Hydrolysis; D008024:Ligands; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D009944:Organoplatinum Compounds; D011355:Prodrugs; D010984:Platinum