title: The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas.
abstract: Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.
authors.affiliation: Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Locatelli
authors.forename: Stefano
authors.initials: S
authors.lastname: Ferrero
authors.forename: Filippo
authors.initials: F
authors.lastname: Martinelli Boneschi
authors.forename: Leonardo
authors.initials: L
authors.lastname: Boiocchi
authors.forename: Mario
authors.initials: M
authors.lastname: Zavanone
authors.forename: Sergio
authors.initials: S
authors.lastname: Maria Gaini
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Bello
authors.forename: Sonia
authors.initials: S
authors.lastname: Valentino
authors.forename: Elisa
authors.initials: E
authors.lastname: Barbati
authors.forename: Manuela
authors.initials: M
authors.lastname: Nebuloni
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.forename: Cecilia
authors.initials: C
authors.lastname: Garlanda
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D001932:Brain Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D002097:C-Reactive Protein / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015254:DNA Modification Methylases / Q000235:genetics; D045643:DNA Repair Enzymes / Q000235:genetics; D004660:Encephalitis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005909:Glioblastoma / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D016015:Logistic Models; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009837:Oligodendroglioma / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D000683:Serum Amyloid P-Component / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D012720:Severity of Illness Index; D025521:Tumor Suppressor Proteins / Q000235:genetics; D000099153:Pentraxins; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D002097:C-Reactive Protein; D015254:DNA Modification Methylases; D045643:DNA Repair Enzymes; D000683:Serum Amyloid P-Component; D025521:Tumor Suppressor Proteins; D000099153:Pentraxins; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C515491:MGMT protein, human