title: Penicillin-induced epileptiform activity elevates focal brain temperature in anesthetized rats.
abstract: To elucidate a relationship between changes in focal brain temperature and severity of abnormal brain activity, epileptiform discharges and behavioral seizures were induced by Penicillin G in anesthetized rats, and focal brain-temperature was measured. Penicillin G was injected into the right primary sensorimotor cortex (400IU/μl). After the injection, epileptiform discharges induced a temperature increase gradually by 0.65±0.24°C. Moreover, when behavioral seizures were induced by reducing the anesthesia level, the temperature was raised by 0.26±0.22°C. These results suggest that elevation of the focal brain temperature is associated with the severity of epileptic activity.
authors.affiliation: Department of Brain Science and Engineering, Kyushu Institute of Technology, Kitakyushu, Japan; Consortium of Advanced Epilepsy Treatment (CADET), Japan.
authors.forename: Tatsuji
authors.initials: T
authors.lastname: Tokiwa
authors.forename: Takao
authors.initials: T
authors.lastname: Inoue
authors.forename: Masami
authors.initials: M
authors.lastname: Fujii
authors.forename: Satoru
authors.initials: S
authors.lastname: Ishizuka
authors.forename: Shuji
authors.initials: S
authors.lastname: Aou
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kida
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Maruta
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Yamakawa
authors.forename: Sadahiro
authors.initials: S
authors.lastname: Nomura
authors.forename: Michiyasu
authors.initials: M
authors.lastname: Suzuki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamakawa
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D010406:Penicillins / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013696:Temperature
chemical_list: D010406:Penicillins
keywords: Behavioral seizures; Epileptiform discharges; Focal brain temperature; Penicillin G; Sensorimotor cortex; Thermocouple