title: Two-in-One antibodies with dual action Fabs.
abstract: Mechanisms and biological roles of antibody multi-specificity are topics of high interest. Evidence of conformational flexibility in antigen-combining sites and their utility in the recognition of different antigens appeared two decades ago. In the last three years an appreciation has emerged that recognition of very much more diverse protein antigens is within the scope of multi-specificity and also that this is sometimes, but not always, associated with structural plasticity. The ability to invent non-promiscuous, high affinity antibodies which are 'specific' for more than one antigen such as the recently described dual-specific Two-in-One DAF antibodies, provides not only insights into the evolution of antibody specificity but also a promise of powerful medicines fully within the paradigm of targeted therapies.
authors.affiliation: Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Eigenbrot
authors.forename: Germaine
authors.initials: G
authors.lastname: Fuh
mesh_terms: D000818:Animals; D018033:Antibodies, Bispecific / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use; D055808:Drug Discovery; D066246:ErbB Receptors / Q000276:immunology; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use; D016296:Mutagenesis; D020893:Receptor, ErbB-3 / Q000276:immunology
chemical_list: D018033:Antibodies, Bispecific; D007140:Immunoglobulin Fab Fragments; D066246:ErbB Receptors; D020893:Receptor, ErbB-3