title: Dilated cardiomyopathy as a presenting feature of Cushing's syndrome.
abstract: Cardiovascular complications, including cardiomegaly, myocardial ischemia and left ventricular hypertrophy, are some of the major determinants of the mortality rate in patients with Cushing's syndrome. We herein report the case of a patient with Cushing's syndrome caused by an adrenal adenoma who presented with congestive heart failure secondary to dilated cardiomyopathy. Follow-up echocardiography showed a marked improvement in the left ventricular cardiac function, and the plasma B-type natriuretic peptide (BNP) levels regressed after successful treatment. "Reversible" dilated cardiomyopathy is rarely associated with Cushing's syndrome; however, it should be recognized. Administering appropriate treatment in a timely manner can reverse this cardiomyopathy along with the other symptoms of Cushing's syndrome.
authors.affiliation: Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan. nshibu@gunma-u.ac.jp
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Shibusawa
authors.forename: Masanobu
authors.initials: M
authors.lastname: Yamada
authors.forename: Tetsu
authors.initials: T
authors.lastname: Hashida
authors.forename: Koshi
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Tetsurou
authors.initials: T
authors.lastname: Satoh
authors.forename: Jun
authors.initials: J
authors.lastname: Horiguchi
authors.forename: Tetsunari
authors.initials: T
authors.lastname: Oyama
authors.forename: Izumi
authors.initials: I
authors.lastname: Takeyoshi
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000601:surgery; D000306:Adrenal Cortex Neoplasms / Q000150:complications* / Q000601:surgery; D000315:Adrenalectomy; D000368:Aged; D015415:Biomarkers; D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000209:etiology*; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002940:Circadian Rhythm; D003480:Cushing Syndrome / Q000150:complications* / Q000175:diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D020097:Natriuretic Peptide, Brain / Q000097:blood; D012074:Remission Induction
chemical_list: D015415:Biomarkers; D002317:Cardiovascular Agents; D006442:Glycated Hemoglobin; D006854:Hydrocortisone; D020097:Natriuretic Peptide, Brain