title: In silico evolution of guiding track designs for molecular shuttles powered by kinesin motors.
abstract: Molecular shuttles powered by kinesin motors require guiding tracks to perform specific tasks in nanoscale devices. Here, using our simulation of molecular shuttle movements, we describe an in silico evolutionary design method that makes it possible to automatically design the guiding tracks in accordance with their functions defined by designers. With this design method, we designed two types of pre-existing guiding track modules with improved performances, as well as one with a novel function.
authors.affiliation: Department of Mathematical and Design Engineering, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Gifu, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Sunagawa
authors.forename: Akihito
authors.initials: A
authors.lastname: Tanahashi
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Downs
authors.forename: Henry
authors.initials: H
authors.lastname: Hess
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nitta
mesh_terms: D000465:Algorithms; D019020:Directed Molecular Evolution; D004867:Equipment Design; D016547:Kinesins / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D008962:Models, Theoretical; D056004:Molecular Dynamics Simulation; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods; D011092:Polyethylene Glycols / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D016547:Kinesins