title: Schiff bases attached L-glutamine and L-asparagine: first investigation on antimutagenic and antimicrobial analyses.
abstract: This study was conducted to evaluate the antimutagenic and antimicrobial activities of Schiff bases attached L-glutamine and L-asparagine. Antibacterial activities of the compounds against S. aureus, Sh. dys. typ 7, L. monocytogenes 4b, E. coli, S. typhi H, S. epidermis, Br. abortus, M. luteus, B. cereus, P. putida, and antifungal activity against Candida albicans were studied. These compounds were investigated for antimutagenic properties against Aflatoxin Bı (AFBı) using micronuclei (MN) assay in human lymphocyte cell culture in vitro. The protective role of these compounds against AFBı-induced MN is probably related to its doses.
authors.affiliation: Department of Chemistry, Ankara University , Ankara , Türkiye.
authors.forename: Iffet
authors.initials: I
authors.lastname: Sakiyan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Anar
authors.forename: Hatice
authors.initials: H
authors.lastname: Oğütcü
authors.forename: Guleray
authors.initials: G
authors.lastname: Agar
authors.forename: Nurşen
authors.initials: N
authors.lastname: Sarı
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology; D001216:Asparagine / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005260:Female; D005973:Glutamine / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000737:chemistry; D015162:Micronucleus Tests; D012545:Schiff Bases / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D016587:Antimutagenic Agents; D012545:Schiff Bases; D005973:Glutamine; D008345:Manganese; D001216:Asparagine
keywords: Aflatoxin Bı; L-Asparagine; L-Glutamine; Mn(III) complexes; Mutagenicity; antimicrobial properties