title: Intraocular penetration of intravenous micafungin in inflamed human eyes.
abstract: Eight eyes of 7 patients with fungal disease received intravenous injections of 150 to 300 mg micafungin, and samples of blood, cornea, retina-choroid, aqueous humor, and vitreous humor were collected. The micafungin levels in all collected samples exceeded the MICs; however, the levels in the vitreous and aqueous humors were lower. Our findings suggest that intravenous micafungin should be given in combination with intravitreal antifungal agents after vitrectomy in severe cases of intraocular fungal diseases.
authors.affiliation: Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan. mochi-gif@umin.ac.jp
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Akira
authors.initials: A
authors.lastname: Sawada
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Suemori
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kawakami
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Niwa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kondo
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Ohkusu
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yamada
authors.forename: Shinji
authors.initials: S
authors.lastname: Ogura
authors.forename: Takashi
authors.initials: T
authors.lastname: Yaguchi
authors.forename: Kazuko
authors.initials: K
authors.lastname: Nishimura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kishino
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001082:Aqueous Humor / Q000378:metabolism; D001230:Aspergillus / Q000187:drug effects / Q000302:isolation & purification; D002175:Candida / Q000187:drug effects / Q000302:isolation & purification; D003315:Cornea / Q000187:drug effects / Q000382:microbiology*; D054714:Echinocandins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D009877:Endophthalmitis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D056965:Injections, Intraocular / Q000379:methods; D055666:Lipopeptides / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D000077551:Micafungin; D014821:Vitrectomy / Q000379:methods; D014822:Vitreous Body / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin