title: Immunohistochemical detection of SATB1 is independent of thyroid cancer differentiation.
abstract: OBJECTIVE
  The association of special AT-rich binding protein 1 (SATB1) with a poor prognosis in various cancers has been reported. However, this association is controversial. SATB1 expression in aggressive types of thyroid cancer has not been reported to date.
  
  
  METHODS
  Retrospective.
  
  
  METHODS
  SATB1 expression was immunohistochemically investigated in 35 papillary thyroid cancers, one follicular thyroid cancer, six poorly differentiated thyroid cancers, and two anaplastic thyroid cancers.
  
  
  RESULTS
  SATB1 expression was observed in none of two anaplastic thyroid cancers, one of six poorly differentiated thyroid cancers, and nine of 36 well-differentiated thyroid cancers. SATB1 expression was not significantly associated with any high-risk group-related clinicopathologic factors in well-differentiated thyroid cancer. Survival was not associated with SATB1 expression.
  
  
  CONCLUSIONS
  SATB1 expression is independent of thyroid cancer differentiation, as well as high-risk-related factors. SATB1 may not play a role in the aggressiveness of thyroid cancer.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Kanazawa University, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Murono
authors.forename: Akira
authors.initials: A
authors.lastname: Tsuji
authors.forename: Kazuhira
authors.initials: K
authors.lastname: Endo
authors.forename: Satoru
authors.initials: S
authors.lastname: Kondo
authors.forename: Naohiro
authors.initials: N
authors.lastname: Wakisaka
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Yoshizaki
mesh_terms: D000230:Adenocarcinoma; D000328:Adult; D006801:Humans; D007150:Immunohistochemistry; D036961:Matrix Attachment Region Binding Proteins / Q000302:isolation & purification*; D008875:Middle Aged; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000737:chemistry* / Q000473:pathology*
chemical_list: D036961:Matrix Attachment Region Binding Proteins; C076189:SATB1 protein, human
keywords: SATB1; aggressiveness; differentiation; high-risk; thyroid cancer