title: GC-MS investigation of Amaryllidaceae alkaloids in Galanthus xvalentinei nothosubsp. subplicatus.
abstract: A GC-MS analysis of alkaloids in the aerial parts and bulbs of Galanthus xvalentinei nothosubsp. subplicatus was performed for the first time. Totally, twenty-six alkaloids were identified, of which tazettine and galanthindole were the major ones. Acetylcholinesterase inhibitory activity of the alkaloidal extracts was determined using modified in vitro Ellman's method. Significant anticholinesterase activity was observed in the tested samples (bulbs: IC50 = 21.3 microg/mL, aerial parts: IC50 = 16.3 microg/mL).
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Ege University, Bornova 35100, Izmir, Turkey. buket.bozkurt@ege.edu.tr
authors.forename: Buket Bozkurt
authors.initials: BB
authors.lastname: Sarikaya
authors.forename: Strahil
authors.initials: S
authors.lastname: Berkov
authors.forename: Jaume
authors.initials: J
authors.lastname: Bastida
authors.forename: Gulen Irem
authors.initials: GI
authors.lastname: Kaya
authors.forename: Mustafa Ali
authors.initials: MA
authors.lastname: Onur
authors.forename: Nehir Unver
authors.initials: NU
authors.lastname: Somer
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D027801:Galanthus / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*
chemical_list: D047151:Amaryllidaceae Alkaloids; D002800:Cholinesterase Inhibitors