title: Seizure severity and health-related quality of life of adult Nigerian patients with epilepsy.
abstract: OBJECTIVE
  There is paucity of information about the association of seizure severity and quality of life in people with epilepsy (PWE) in sub-Saharan Africa. We evaluated the relationship of seizure severity to health-related quality of life of patients with epilepsy being followed up in an outpatient neurology clinic in southwestern Nigeria.
  
  
  METHODS
  Eighty-eight consecutive patients with epilepsy who met the recruitment criteria completed the study questionnaire in company of an eyewitness. The study questionnaire comprised of the National Hospital Seizure Severity Scale (NHS3), the Quality of Life Inventory in Epilepsy (QOLIE-31), and the Beck's Depression Inventory-II (BDI-II).
  
  
  RESULTS
  We found a minute association between seizure severity and QOLIE-31 total score (r = -0.262, P = 0.014). Increased seizure severity predicted a worse QOLIE-31 seizure worry (R(2) = 0.311, β = -0.289; P = 0.003). Of the seven seizure severity items, generalization of seizures and presence of falls were items that predicted a worse QOLIE-31 seizure worry score and time to recover predicted a worse QOLIE-31 total score.
  
  
  CONCLUSIONS
  Reducing seizure severity may be an alternate endpoint in epilepsy care in Nigeria (particularly difficult to control seizures) because of its practical clinical relevance in view of the fact that state-of-the-art epilepsy care is still farfetched.
authors.affiliation: Neurology Unit, Department of Medicine, Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria; Neurology Unit, Department of Medicine, Faculty of Clinical Sciences, Ladoke Akintola Univeristy/Ladoke Akintola University Teaching Hospital, Ogbomoso, Oyo-state, Nigeria.
authors.forename: P B
authors.initials: PB
authors.lastname: Adebayo
authors.forename: R O
authors.initials: RO
authors.lastname: Akinyemi
authors.forename: S A
authors.initials: SA
authors.lastname: Ogun
authors.forename: A
authors.initials: A
authors.lastname: Ogunniyi
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D009549:Nigeria; D011788:Quality of Life; D012640:Seizures / Q000523:psychology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
keywords: African; Nigeria; adult; epilepsy; quality of life; seizure severity