title: Congenital chylothorax and pulmonary hypertension complicated with heart failure and hepatopathy.
abstract: Respiratory difficulty resulting from congenital chylothorax is usually relieved by postnatal thoracentesis, closed chest drainage, and oxygen therapy. However, early occurrence of congenital chylothorax or accumulation of a large amount of chylous fluid sometimes leads to pulmonary hypoplasia or persistent pulmonary hypertension of the newborn, which requires further customized mechanical ventilatory support. In these cases, conventional mechanical ventilation is primarily used during initial treatment and is later replaced by high-frequency ventilation, but the advantages of inhaled nitric oxide treatment have rarely been described. This case suggests the benefits of inhaled nitric oxide in patients with congenital chylothorax, even when mechanical ventilation cannot improve respiratory distress because of severe pulmonary hypertension of the newborn leading to right cardiac dysfunction and possibly cholestasis.
authors.affiliation: Department of Pediatrics Obstetrics, College of Medicine, Catholic University of Korea, Seoul, Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Oh
authors.forename: Guisera
authors.initials: G
authors.lastname: Lee
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000015:Abnormalities, Multiple; D000280:Administration, Inhalation; D002916:Chylothorax / Q000150:complications / Q000151:congenital* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006612:High-Frequency Ventilation; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000151:congenital* / Q000628:therapy; D007231:Infant, Newborn; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D009569:Nitric Oxide / Q000008:administration & dosage*; D010102:Oxygen Inhalation Therapy; D010547:Persistent Fetal Circulation Syndrome / Q000175:diagnosis; D011247:Pregnancy
chemical_list: D009569:Nitric Oxide