title: Effects of low-dose aspirin and fish oil on platelet function and NF-kappaB in adults with diabetes mellitus.
abstract: BACKGROUND
  Many diabetics are insensitive to aspirin's platelet anti-aggregation effects. The possible modulating effects of co-administration of aspirin and fish oil in subjects with diabetes are poorly characterized.
  
  
  METHODS
  Thirty adults with type 2 diabetes mellitus were treated with aspirin 81 mg/d for 7 days, then with fish oil 4 g/day for 28 days, then the combination of fish oil and aspirin for another 7 days.
  
  
  RESULTS
  Aspirin alone and in combination with fish oil reduced platelet aggregation in most participants. Five of 7 participants classified as aspirin insensitive 1 week after daily aspirin ingestion were sensitive after the combination. Although some platelet aggregation measures correlated positively after aspirin and fish oil ingestion alone and (in combination) in all individuals, correlation was only observed in those who were aspirin insensitive after ingestion of the combination.
  
  
  CONCLUSIONS
  Co-administration of aspirin and fish oil may reduce platelet aggregation more than aspirin alone in adults with diabetes mellitus.
authors.affiliation: Department of Public Health Sciences, The University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. robert_block@urmc.rochester.edu
authors.forename: Robert C
authors.initials: RC
authors.lastname: Block
authors.forename: Amir
authors.initials: A
authors.lastname: Abdolahi
authors.forename: Brian
authors.initials: B
authors.lastname: Smith
authors.forename: N
authors.initials: N
authors.lastname: Meednu
authors.forename: Kelly
authors.initials: K
authors.lastname: Thevenet-Morrison
authors.forename: Xueya
authors.initials: X
authors.lastname: Cai
authors.forename: Huadong
authors.initials: H
authors.lastname: Cui
authors.forename: Shaker
authors.initials: S
authors.lastname: Mousa
authors.forename: J Thomas
authors.initials: JT
authors.lastname: Brenna
authors.forename: S
authors.initials: S
authors.lastname: Georas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism*; D010974:Platelet Aggregation / Q000187:drug effects; D010979:Platelet Function Tests
chemical_list: D005395:Fish Oils; D016328:NF-kappa B; D001241:Aspirin