title: [Genetics of schizophrenia].
abstract: Many studies have reported that genetic variants play a major role in the pathogenesis of schizophrenia. In the past five years, the genetics knowledge base of schizophrenia has advanced considerably. These advances have mostly been through genome-wide association studies (GWAS) and copy number variations (CNVs) studies. Moreover, exome sequencing by using the next-generation DNA sequencers is launched in recent years. In the next few years, the high-throughput sequencing is likely to play an important role. These findings have produced new hypotheses about etiology of schizophrenia and they can indicate future research strategies. Therefore, it is expected that further studies will yield deeper insights.
authors.affiliation: Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Jitoku
authors.forename: Takeo
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D056915:DNA Copy Number Variations / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D057089:Pathology, Molecular / Q000379:methods; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods