title: Hepatitis C virus genotypes among patients with lichen planus in the Kingdom of Saudi Arabia.
abstract: OBJECTIVE
  This study aimed to determine the prevalence of anti-hepatitis C virus (HCV) antibodies and HCV genotypes/subtypes among patients with lichen planus (LP) in Saudi Arabia.
  
  
  METHODS
  Fifty patients with LP and 50 healthy blood donors were recruited from dermatology outpatient clinics, and blood samples along with demographic and clinical data were collected. Sera were analyzed for aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, bilirubin, hepatitis B virus surface antigen, anti-HCV antibodies, and HCV-RNA. Patients with anti-HCV-positive LP were genotyped and subtyped.
  
  
  RESULTS
  Clinical examination revealed that 26 (55.3%) of our patients had cutaneous LP, and 10 (21.30%) presented with oral LP. Eleven (23.4%) patients with LP had cutaneous as well as oral infection. Twenty-eight (59.6%) of our patients with LP were exposed to a variety of HCV risk factors, including history of intramuscular injections (nine of 47; 19%), blood transfusion (seven of 47; 15%), and exposure to family member with HCV infection (five of 47; 10.6%). Of the 47 patients with LP, six (12.76%) tested positive for anti-HCV antibodies, with two of six (33.33%) being HCV-RNA positive showing HCV genotypes 1b and 4a, respectively. Mean ± SD serum levels of ALT and AST among patients with anti-HCV-positive LP (n = 6) were slightly higher as compared with patients with anti-HCV-negative LP. None of the 50 healthy blood donors tested positive for anti-HCV antibodies, and their liver function test profiles were within normal reference range.
  
  
  CONCLUSIONS
  Our findings are in agreement with earlier reports that HCV infection is associated with LP and recommend the screening of patients with LP for ALT, AST, and anti-HCV antibodies for early diagnosis of HCV infection.
authors.affiliation: Department of Dermatology, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Mona
authors.initials: M
authors.lastname: Halawani
mesh_terms: D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics* / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000097:blood; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000150:complications; D006801:Humans; D008010:Lichen Planus / Q000097:blood* / Q000150:complications; D017676:Lichen Planus, Oral / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012367:RNA, Viral / Q000097:blood*; D012307:Risk Factors; D012529:Saudi Arabia; D012709:Serum Albumin / Q000378:metabolism; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens; D012367:RNA, Viral; D012709:Serum Albumin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin