title: RhoGTPases--NODes for effector-triggered immunity in animals.
abstract: A recent study published in Nature by Keestra and colleagues addresses how the immune system detects the pathogenic potential of microbes and provides evidence that one strategy involves NOD1, which monitors the activation state of the RhoGTPases that are targeted by virulence effectors produced by pathogenic microbes. Interestingly, their findings reveal striking similarities with previous observations made in flies and plants, establishing the evolutionary conservation of this detection system in the innate immune arsenal in many taxa.
authors.affiliation: Developmental Immunology and Center for Computational and Integrative Biology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA. lstuart@partners.org
authors.forename: Lynda M
authors.initials: LM
authors.lastname: Stuart
authors.forename: Laurent
authors.initials: L
authors.lastname: Boyer
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D053474:Nod1 Signaling Adaptor Protein / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000378:metabolism* / Q000472:pathogenicity*; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D053474:Nod1 Signaling Adaptor Protein; D020741:rho GTP-Binding Proteins