title: Effect of Daikenchuto (TJ-100) on abdominal bloating in hepatectomized patients.
abstract: OBJECTIVE
  To evaluate the clinical usefulness of Daikenchuto (DKT) in hepatecomized patients.
  
  
  METHODS
  Twenty patients were enrolled with informed consent. Two patients were excluded because of cancelled operations. The remaining 18 patients were randomly chosen for treatment with DKT alone or combination therapy of DKT and lactulose (n = 9, each group). Data were prospectively collected. Primary end points were Visual Analogue Scale (VAS) score for abdominal bloating, total Gastrointestinal Symptoms Rating Scale (GSRS) score for abdominal symptoms, and GSRS score for abdominal bloating.
  
  
  RESULTS
  The VAS score for abdominal bloating and total GSRS score for abdominal symptoms recovered to levels that were not significantly different to preoperative levels by 10 d postoperation. Combination therapy of DKT and lactulose was associated with a significantly poorer outcome in terms of VAS and GSRS scores for abdominal bloating, total GSRS score, and total daily calorie intake, when compared with DKT alone therapy.
  
  
  CONCLUSIONS
  DKT is a potentially effective drug for postoperative management of hepatectomized patients, not only to ameliorate abdominal bloating, but also to promote nutritional support by increasing postoperative dietary intake.
authors.affiliation: Kazuhiro Hanazaki, Kengo Ichikawa, Masaya Munekage, Hiroyuki Kitagawa, Ken Dabanaka, Tsutomu Namikawa, Department of Surgery, Kochi Medical School, Kochi University, Kochi 783-8505, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hanazaki
authors.forename: Kengo
authors.initials: K
authors.lastname: Ichikawa
authors.forename: Masaya
authors.initials: M
authors.lastname: Munekage
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kitagawa
authors.forename: Ken
authors.initials: K
authors.lastname: Dabanaka
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Namikawa
keywords: Abdominal bloating; Daikenchuto; Gastrointestinal symptoms rating scale score; Hepatic resection; Visual analogue scale score