title: Pegylated IL-10 induces cancer immunity: the surprising role of IL-10 as a potent inducer of IFN-γ-mediated CD8(+) T cell cytotoxicity.
abstract: Recently, the development of several strategies based on immunotherapy has raised hopes for a more promising way to treat cancer patients. Here, we describe how interleukin (IL)-10, a seemingly unlikely candidate, stimulates the immune system in a particularly efficacious way. IL-10, an omnipotent anti-inflammatory cytokine, delivers an equally potent immune stimulation in the context of CD8(+) T cells and tumor immunity. By activation of tumor-resident, tumor-specific CD8(+) T cells, pegylated IL-10 can induce rejection of large and metastasizing tumors in mice. Here, we summarize the mechanisms of action of IL-10, the reasons why the mechanisms may be crucial for the treatment of cancer patients, and the rationale for applying pegylated IL-10 in the clinic.
authors.affiliation: ARMO Biosciences, Redwood City, CA, USA.
authors.forename: John B
authors.initials: JB
authors.lastname: Mumm
authors.forename: Martin
authors.initials: M
authors.lastname: Oft
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007371:Interferon-gamma / Q000276:immunology / Q000378:metabolism*; D016753:Interleukin-10 / Q000494:pharmacology*; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D011092:Polyethylene Glycols / Q000494:pharmacology*
chemical_list: D016753:Interleukin-10; D011092:Polyethylene Glycols; D007371:Interferon-gamma