title: Carvedilol.
abstract: Carvedilol ((2RS)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propan-2-ol), a β1-, β2-, and α1-adrenoreceptor blocker drug with antioxidant and antiproliferative effects, is indicated for treatment of hypertension, stable angina pectoris, and congestive heart failure. A profile of this drug substance is provided in this chapter and includes physical characteristics of Carvedilol (e.g., UV-vis, IR, NMR, and mass spectra). Details regarding the stability of Carvedilol in the solid state and solution phase are presented and methods of analysis (compendial and literature) are summarized. Furthermore, an account of the pharmacokinetics (ADME) and synthesis of Carvedilol are presented.
authors.affiliation: Apotex Inc., Toronto, Ontario, Canada.
authors.forename: Kevin
authors.initials: K
authors.lastname: Beattie
authors.forename: Geeta
authors.initials: G
authors.lastname: Phadke
authors.forename: Jasmina
authors.initials: J
authors.lastname: Novakovic
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry*; D002227:Carbazoles / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D000077261:Carvedilol; D003461:Crystallography; D004355:Drug Stability; D006801:Humans; D011412:Propanolamines / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D012995:Solubility; D013057:Spectrum Analysis
chemical_list: D000959:Antihypertensive Agents; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol