title: Synthesis and Evaluation of Benzophenone-N-ethyl Morpholine Ethers as Anti-inflammatory Agents.
abstract: The synthesis of hydroxy benzophenones and benzophenone-N-ethyl morpholine ethers and the results of anti-inflammatory activity in vivo are described. The structures of the compounds were elucidated by IR, (1)H-NMR, mass spectroscopy and the elementary analysis. The anti-inflammatory activity of the synthesized compounds were determined by carrageenan-induced hind paw oedema test in rats. Most of the tested compounds exhibited anti-inflammatory activity and some of them were more active than standard drugs. In addition ulcerogenic and cyclooxygenase activities are also described.
authors.affiliation: Department of Chemistry, Yuvaraja college, University of Mysore, Mysore Karnataka, India;
authors.forename: Shaukath A
authors.initials: SA
authors.lastname: Khanum
authors.forename: Bushra A
authors.initials: BA
authors.lastname: Begum
authors.forename: V
authors.initials: V
authors.lastname: Girish
authors.forename: Noor Fatima
authors.initials: NF
authors.lastname: Khanum
keywords: acute toxicity; anti-inflammatory; cyclooxygenase; morpholines; ulcerogenic