title: Cardiovascular toxicity and sorafenib: a case report.
abstract: We report a case of a 55-year-old male with chronic hepatitis C virus infection and compensated liver disease treated with sorafenib for advanced hepatocarcinoma (Barcelona Clinic Liver Cancer stage C). At follow-up, the patient developed hypertension, which was well controlled with beta-blocker medication, and an aortic dilation detected by abdominal computerized tomography and echocardiography. There are some reports of the side effects of sorafenib on the cardiovascular system. The patient had no cardiac or aortic pathology before the start of this palliative chemotherapy. There is an article that describes the development of an aortic aneurysm in a patient with uncontrolled hypertension, who received treatment with sorafenib for renal carcinoma. However, our patient had a good control of blood pressure. The adverse vascular effects of Sorafenib may be due to the inhibition of the proliferation of vascular endothelial muscle cells. We believe that this case illustrates a probable relationship between sorafenib and aortic dilatation according to the Karch and Lasagna causality algorithm.
authors.affiliation: Departments of 1Gastroenterology and Hepatology and 2Pharmacy, Hospital General Universitario Gregorio Marañón, Madrid, Spain; and 3Department of Hematology, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: García-Lledó
authors.forename: Lucía
authors.initials: L
authors.lastname: Cortejoso
authors.forename: María
authors.initials: M
authors.lastname: Tenorio Núñez
authors.forename: Alvaro
authors.initials: A
authors.lastname: Giménez-Manzorro
authors.forename: Ana
authors.initials: A
authors.lastname: Matilla-Peña
authors.forename: Magdalena
authors.initials: M
authors.lastname: Salcedo-Plaza
authors.forename: María
authors.initials: M
authors.lastname: Sanjurjo-Sáez
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D001011:Aorta / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000009:adverse effects / Q000031:analogs & derivatives*; D010671:Phenylurea Compounds / Q000009:adverse effects*; D000077157:Sorafenib
chemical_list: D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D009536:Niacinamide; D000077157:Sorafenib