title: Clinical Outcome of High Risk Gastrointestinal Stromal Tumor in a Meckel's Diverticulum.
abstract: We describe a seven years follow-up of a high risk gastrointestinal stromal tumor in a Meckel's diverticulum in a 68-year-old man with abdominal pain and vomiting. The patient was operated in emergency for peritonitis due to perforation of small intestine and treated with imatinib mesylate. The metastatic progression of the disease demonstrated the value of prognostic indicators (mitotic rate >10/50 high power field, necrosis and 8 cm in maximum diameter) for assessing risk of aggressive behaviour. Computed tomography was a valuable procedure for detection of local recurrence, the distant metastases and for surveillance after surgery in the follow-up. The review of the literature shows that this case has the longest follow up and consents the comparisons of the same neoplasm in other sites most frequent and better described than Meckel's diverticulum.
authors.affiliation: Department of Surgery Radiology, Odontostomatology Science, Section of Diagnostic and Interventional Radiology, University of Perugia, S. Maria della Misericordia Hospital, S. Andrea delle Fratte, 06156 Perugia, Italy;
authors.forename: Michele
authors.initials: M
authors.lastname: Scialpi
authors.forename: Christian
authors.initials: C
authors.lastname: Franzini
authors.forename: Antonio
authors.initials: A
authors.lastname: Cavaliere
authors.forename: Francesco
authors.initials: F
authors.lastname: Barberini
authors.forename: Irene
authors.initials: I
authors.lastname: Piscioli
authors.forename: Ilaria
authors.initials: I
authors.lastname: Franceschetti
authors.forename: Luciano
authors.initials: L
authors.lastname: Lupattelli
keywords: Meckel diverticulum; gastrointestinal stromal tumor; imatinib mesylate