title: Genetic structure of Mexican Mestizos with type 2 diabetes mellitus based on three STR loci.
abstract: BACKGROUND
  The aims of this population genetics study were: 1) to ascertain whether Mexicans with type 2 diabetes mellitus (DM) were genetically homogeneous and 2) to compare the genetic structure of this selected population with the previously reported data of four random populations (Nuevo León, Hispanics, Chihuahua, and Central Region of Mexico).
  
  
  METHODS
  A sample of 103 unrelated individuals with DM and whose 4 grandparents were born in five zones of Mexico was interviewed in 32 Medical Units in the Mexican Institute of Social Security (IMSS). The non-coding STRs D16S539, D7S820, and D13S317 were analyzed.
  
  
  RESULTS
  Genotype distribution was in agreement with Hardy-Weinberg expectations for all three markers. Allele frequencies were found to be similar between the selected population and the four random populations. Gene diversity analysis suggested that more than 99.57% of the total gene diversity could be attributed to variation between individuals within the population and 0.43% between the populations.
  
  
  CONCLUSIONS
  According to the present and previous studies using molecular and non-molecular nuclear DNA markers not associated with any disease, the Mexican Mestizo population is found to be genetically homogeneous and therefore the genetic causes of DM are less heterogeneous, thereby simplifying genetic epidemiological studies as has been found in a previous study with the same design in Mexican women with breast cancer.
authors.affiliation: Universidad Autónoma de Nuevo León, Facultad de Enfermería, Monterrey, Mexico. ricardocerda_mx@yahoo.com.mx
authors.forename: Ricardo M
authors.initials: RM
authors.lastname: Cerda-Flores
authors.forename: Roxana A
authors.initials: RA
authors.lastname: Rivera-Prieto
authors.forename: Benito
authors.initials: B
authors.lastname: Pereyra-Alférez
authors.forename: Ana L
authors.initials: AL
authors.lastname: Calderón-Garcidueñas
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Barrera-Saldaña
authors.forename: Hugo L
authors.initials: HL
authors.lastname: Gallardo-Blanco
authors.forename: Rocío
authors.initials: R
authors.lastname: Ortiz-López
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Flores-Peña
authors.forename: Velia M
authors.initials: VM
authors.lastname: Cárdenas-Villarreal
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivas
authors.forename: Andrés
authors.initials: A
authors.lastname: Figueroa
authors.forename: Gautam
authors.initials: G
authors.lastname: Kshatriya
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D005828:Genetics, Population / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D017058:Mexican Americans / Q000235:genetics*; D018895:Microsatellite Repeats; D008875:Middle Aged; D025341:Principal Component Analysis / Q000379:methods