title: Phenylethanoid glycosides with anti-inflammatory activities from the stems of Cistanche deserticola cultured in Tarim desert.
abstract: Five new phenylethanoid glycosides, cistanosides J-N (1-5), together with 15 known ones (6-20) were isolated from the stems of Cistanche deserticola cultured in Tarim desert, China. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR) and chemical degradation. All the compounds obtained were examined for their inhibitory effect on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse microglial cells (BV-2 cells), and compounds 2 and 8 showed potent inhibition on the NO production with IC50 values of 14.94 μM and 14.32 μM, respectively.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Ze-dong
authors.initials: ZD
authors.lastname: Nan
authors.forename: Ke-wu
authors.initials: KW
authors.lastname: Zeng
authors.forename: She-po
authors.initials: SP
authors.lastname: Shi
authors.forename: Ming-bo
authors.initials: MB
authors.lastname: Zhao
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.forename: Peng-fei
authors.initials: PF
authors.lastname: Tu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D002681:China; D031671:Cistanche / Q000737:chemistry*; D017753:Ecosystem; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides; D051379:Mice; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D005960:Glucosides; D006027:Glycosides; D008070:Lipopolysaccharides; D010936:Plant Extracts; C586578:cistanoside K; C111523:tubuloside B; D009569:Nitric Oxide
keywords: Anti-inflammatory activity; Cistanche deserticola; Cistanoside; Phenylethanoid glycoside