title: Luring BRCA1 to the scene of the crime.
abstract: To preserve genome stability, BRCA1 must be recruited to sites of DNA damage, where BRCA1 facilitates repair of double-strand DNA breaks (DSBs). In this issue of Cancer Cell, Li and Yu report that BRCA1 recruitment involves a novel interaction between its partner protein BARD1 and poly(ADP-ribose) chains at the DSB.
authors.affiliation: Institute for Cancer Genetics, Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA. rb670@columbia.edu
authors.forename: Richard
authors.initials: R
authors.lastname: Baer
mesh_terms: D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D044767:Ubiquitin-Protein Ligases / Q000502:physiology*
chemical_list: C111164:BRAP protein, human; D044767:Ubiquitin-Protein Ligases