title: The role of prestimulus activity in visual extinction.
abstract: Patients with visual extinction following right-hemisphere damage sometimes see and sometimes miss stimuli in the left visual field, particularly when stimuli are presented simultaneously to both visual fields. Awareness of left visual field stimuli is associated with increased activity in bilateral parietal and frontal cortex. However, it is unknown why patients see or miss these stimuli. Previous neuroimaging studies in healthy adults show that prestimulus activity biases perceptual decisions, and biases in visual perception can be attributed to fluctuations in prestimulus activity in task relevant brain regions. Here, we used functional MRI to investigate whether prestimulus activity affected perception in the context of visual extinction following stroke. We measured prestimulus activity in stimulus-responsive cortical areas during an extinction paradigm in a patient with unilateral right parietal damage and visual extinction. This allowed us to compare prestimulus activity on physically identical bilateral trials that either did or did not lead to visual extinction. We found significantly increased activity prior to stimulus presentation in two areas that were also activated by visual stimulation: the left calcarine sulcus and right occipital inferior cortex. Using dynamic causal modelling (DCM) we found that both these differences in prestimulus activity and stimulus evoked responses could be explained by enhanced effective connectivity within and between visual areas, prior to stimulus presentation. Thus, we provide evidence for the idea that differences in ongoing neural activity in visually responsive areas prior to stimulus onset affect awareness in visual extinction, and that these differences are mediated by fluctuations in extrinsic and intrinsic connectivity.
authors.affiliation: UCL Institute of Cognitive Neuroscience, London WC1N 3AR, UK. maren.urner.09@ucl.ac.uk
authors.forename: Maren
authors.initials: M
authors.lastname: Urner
authors.forename: Margarita
authors.initials: M
authors.lastname: Sarri
authors.forename: Jessica
authors.initials: J
authors.lastname: Grahn
authors.forename: Tom
authors.initials: T
authors.lastname: Manly
authors.forename: Geraint
authors.initials: G
authors.lastname: Rees
authors.forename: Karl
authors.initials: K
authors.lastname: Friston
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001930:Brain Injuries / Q000150:complications* / Q000473:pathology; D005108:Extinction, Psychological / Q000502:physiology*; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D009483:Neuropsychological Tests; D017711:Nonlinear Dynamics; D010100:Oxygen; D010468:Perceptual Disorders / Q000209:etiology*; D010775:Photic Stimulation; D013997:Time Factors; D014793:Visual Cortex / Q000098:blood supply / Q000503:physiopathology; D014794:Visual Fields / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*
chemical_list: D010100:Oxygen