title: Role of F18-FDG-PET/CT in restaging patients affected by renal carcinoma.
abstract: BACKGROUND
  Renalcancers account for around 3% of all cancers and the most common type of (90%) is renal cell carcinoma Five-year survival rate in renal cancer patients is 68.4%.
  
  
  OBJECTIVE
  The aim of our study was to establish the role of F18-FDG-PET/CT in restaging patients with renal carcinoma who underwent partial or radical nephrectomy. Secondary aim of the study was to identify histological characteristics of the primary tumour that may be responsible for the metabolic behaviour of neoplastic lesions.
  
  
  METHODS
  We retrospectively evaluated 68 patients with renal carcinoma in whom F18-FDG-PET/CT was performed.
  
  
  RESULTS
  Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of F18-FDG PET/CT were 82%, 100%, 100%, 66.7% and 86.8%, respectively.
  
  
  CONCLUSIONS
  The results of our study suggest that F18-FDG PET/CT is characterised by high specificity and positive predictive value and can be useful in restaging patients affected by renal carcinoma. However, due to low negative predictive value, this method cannot be recommended for definitely ruling out suspected disease relapse.
authors.affiliation: Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, Brescia, Italy. francesco.bertagna@med.unibs.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertagna
authors.forename: Federica
authors.initials: F
authors.lastname: Motta
authors.forename: Mattia
authors.initials: M
authors.lastname: Bertoli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Bosio
authors.forename: Simona
authors.initials: S
authors.lastname: Fisogni
authors.forename: Regina
authors.initials: R
authors.lastname: Tardanico
authors.forename: Vittorio
authors.initials: V
authors.lastname: Ferrari
authors.forename: Alessandro
authors.initials: A
authors.lastname: Antonelli
authors.forename: Claudio
authors.initials: C
authors.lastname: Simeone
authors.forename: Sergio
authors.initials: S
authors.lastname: Cosciani Cunico
authors.forename: Raffaele
authors.initials: R
authors.lastname: Giubbini
mesh_terms: D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008297:Male; D064847:Multimodal Imaging; D009367:Neoplasm Staging; D009392:Nephrectomy; D049268:Positron-Emission Tomography; D012015:Reference Standards; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18