title: The use of steroids to prevent cutaneous reactions to benznidazole in patients with Chagas disease.
abstract: The treatment of Chagas disease is limited by the frequent cutaneous side effects of benznidazole. We tested the use of steroids plus escalating doses of benznidazole to prevent this complication in 17 adult patients with chronic Trypanosoma cruzi infection and found extremely good tolerance. A randomized trial is warranted.
authors.affiliation: Division of Infectious Diseases, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain. mgorgolas@me.com
authors.forename: Miguel
authors.initials: M
authors.lastname: Górgolas
authors.forename: Ignacio
authors.initials: I
authors.lastname: Robles
authors.forename: Alfonso
authors.initials: A
authors.lastname: Cabello
authors.forename: Ramón
authors.initials: R
authors.lastname: Pérez-Tanoira
authors.forename: Concepción Pérez-Jorge
authors.initials: CP
authors.lastname: Peremarch
authors.forename: Ricardo
authors.initials: R
authors.lastname: Fernández-Roblas
authors.forename: Frances
authors.initials: F
authors.lastname: Williams
authors.forename: José Manuel Ramos
authors.initials: JM
authors.lastname: Rincón
mesh_terms: D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D014355:Chagas Disease / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D012871:Skin Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D013256:Steroids / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D009593:Nitroimidazoles; D013256:Steroids; C009999:benzonidazole