title: The time-course of hindbrain neuronal activity varies according to location during either intraperitoneal or subcutaneous tumor growth in rats: single Fos and dual Fos/dopamine β-hydroxylase immunohistochemistry.
abstract: Neuronal activity in the nucleus of the solitary tract, ventrolateral medulla, area postrema, and parabrachial nucleus was studied in rats with intraperitoneal or subcutaneous tumors on the 7th, 14th, 21st, and 28th day after injection of fibrosarcoma tumor cells. We found that the number of Fos and dopamine β-hydroxylase immunopositive neurons differs between animals with intraperitoneal and subcutaneous tumors and also between tumor-bearing rats at different times following injection. Our data indicate that responses of the brainstem structures to peripheral tumor growth depend on the localization as well as the stage of the tumor growth.
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 83306 Bratislava, Slovakia.
authors.forename: Lubica
authors.initials: L
authors.lastname: Lackovicova
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Gaykema
authors.forename: Lucia
authors.initials: L
authors.lastname: Banovska
authors.forename: Alexander
authors.initials: A
authors.lastname: Kiss
authors.forename: Lisa E
authors.initials: LE
authors.lastname: Goehler
authors.forename: Boris
authors.initials: B
authors.lastname: Mravec
mesh_terms: D000818:Animals; D031608:Area Postrema / Q000201:enzymology / Q000503:physiopathology; D015415:Biomarkers / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D005354:Fibrosarcoma / Q000473:pathology / Q000503:physiopathology*; D007150:Immunohistochemistry; D053583:Interleukin-1beta / Q000097:blood; D008297:Male; D008526:Medulla Oblongata / Q000201:enzymology / Q000503:physiopathology; D009368:Neoplasm Transplantation; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000503:physiopathology*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012249:Rhombencephalon / Q000201:enzymology / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000503:physiopathology*; D017552:Solitary Nucleus / Q000201:enzymology / Q000503:physiopathology; D040521:Subcutaneous Tissue / Q000473:pathology / Q000503:physiopathology*; D013997:Time Factors; D047368:Tumor Burden; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D053583:Interleukin-1beta; D016760:Proto-Oncogene Proteins c-fos; D014409:Tumor Necrosis Factor-alpha; D004299:Dopamine beta-Hydroxylase