title: Screening for maternal coeliac disease as a potential risk factor for orofacial clefts--a pilot study.
abstract: There is increasing evidence that dietary folic acid deficiency in utero may increase the risk of developing the 'cleft lip with or without cleft palate' (CL±P) variant of orofacial cleft. Coeliac disease is a common cause of folic acid malabsorption, and in the majority of cases remains undiagnosed. This pilot study assessed the seroprevalence of undiagnosed coeliac disease in a cohort of mothers of infants with CL±P in the Hyderabad area of India. The seroprevalence of coeliac disease of 1.15% (95% confidence interval 0.37-2.66%) was little different from the expected figure based on published population studies, making a clinically significant association unlikely.
authors.affiliation: GSR Institute of Craniofacial Surgery, Saidabad, Hyderabad, India.
authors.forename: S G
authors.initials: SG
authors.lastname: Reddy
authors.forename: R R
authors.initials: RR
authors.lastname: Reddy
authors.forename: A
authors.initials: A
authors.lastname: Vaidhyanathan
authors.forename: A
authors.initials: A
authors.lastname: Markus
authors.forename: J
authors.initials: J
authors.lastname: Snook
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D002971:Cleft Lip / Q000209:etiology* / Q000517:prevention & control; D002972:Cleft Palate / Q000209:etiology* / Q000517:prevention & control; D016001:Confidence Intervals; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005494:Folic Acid Deficiency / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D008297:Male; D010865:Pilot Projects; D011247:Pregnancy; D012307:Risk Factors; D011503:Transglutaminases / Q000097:blood
chemical_list: D011503:Transglutaminases
keywords: cleft lip; cleft palate; coeliac disease