title: Antitumoral effects of vasoactive intestinal peptide in human renal cell carcinoma xenografts in athymic nude mice.
abstract: We studied antitumor effect of VIP in human renal cell carcinoma (RCC) (A498 cells xenografted in immunosuppressed mice). VIP-treated cells gave resulted in p53 upregulation and decreased nuclear β-catenin translocation and NFκB expression, MMP-2 and MMP-9 activities, VEGF levels and CD-34 expression. VIP led to a more differentiated tubular organization in tumours and less metastatic areas. Thus, VIP inhibits growth of A498-cell tumours acting on the major issues involved in RCC progression such as cell proliferation, microenvironment remodelling, tumour invasion, angiogenesis and metastatic ability. These antitumoral effects of VIP offer new therapeutical possibilities in RCC treatment.
authors.affiliation: Department of Systems Biology, Unit of Biochemistry and Molecular Biology, University of Alcalá, 28871 Alcalá de Henares, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Vacas
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Arenas
authors.forename: Laura
authors.initials: L
authors.lastname: Muñoz-Moreno
authors.forename: Ana M
authors.initials: AM
authors.lastname: Bajo
authors.forename: Manuel
authors.initials: M
authors.lastname: Sánchez-Chapado
authors.forename: Juan C
authors.initials: JC
authors.lastname: Prieto
authors.forename: María J
authors.initials: MJ
authors.lastname: Carmena
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D002292:Carcinoma, Renal Cell / Q000378:metabolism*; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*; D051176:beta Catenin / Q000378:metabolism
chemical_list: D051176:beta Catenin; D014660:Vasoactive Intestinal Peptide