title: Coupling the cell cycle to development and regeneration of the inner ear.
abstract: Cell cycle exit and acquirement of a postmitotic state is essential for the proper development of organs. In the present review, we examine the role of the cell cycle control in the sensory epithelia of the mammalian inner ear. We describe the roles of the core cell cycle regulators in the proliferation of prosensory cells and in the initiation and maintenance of terminal mitosis of the sensory epithelia. We also discuss how other intracellular signalling may influence the cell cycle. Finally, we address the question of whether manipulations of the cell cycle may have the potential to create replacement cells for the damaged inner sensory epithelia.
authors.affiliation: Instituto de Biología y Genética Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Científicas, Valladolid, Spain.
authors.forename: Thomas
authors.initials: T
authors.lastname: Schimmang
authors.forename: Ulla
authors.initials: U
authors.lastname: Pirvola
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D018507:Gene Expression Regulation, Developmental; D006198:Hair Cells, Auditory / Q000166:cytology / Q000502:physiology*; D006801:Humans; D007760:Labyrinth Supporting Cells / Q000166:cytology / Q000502:physiology*; D009024:Morphogenesis / Q000502:physiology; D051880:Receptors, Notch / Q000235:genetics* / Q000378:metabolism; D012038:Regeneration; D015398:Signal Transduction
chemical_list: D018797:Cell Cycle Proteins; D051880:Receptors, Notch