title: [Anesthesia-related cardiac arrest in children. Data from a tertiary referral hospital registry].
abstract: OBJECTIVE
  The aim of this study is to analyze the cardiac arrests related to anesthesia in a tertiary children's hospital, in order to identify risk factors that would lead to opportunities for improvement.
  
  
  METHODS
  A 5-year retrospective study was conducted on anesthesia related cardiac arrest occurring in pediatric patients. All urgent and elective anesthetic procedures performed by anesthesiologists were included. Data collected included patient characteristics, the procedure, the probable cause, and outcome of the cardiac arrest. Odds ratio was calculated by univariate analysis to determine the clinical factors associated with cardiac arrest and mortality.
  
  
  RESULTS
  There were a total of 15 cardiac arrests related to anesthesia in 43,391 anesthetic procedures (3.4 per 10,000), with an incidence in children with ASA I-II versus ASA≥III of 0.28 and 19.27 per 10,000, respectively. The main risk factors were children ASA≥III (P<.001), less than one month old (P<.001), less than one year old (P<.001), emergency procedures (P<.01), cardiac procedures (P<.001) and procedures performed in the catheterization laboratory (P<.05). The main causes of cardiac arrest were cardiovascular (53.3%), mainly due to hypovolemia, and cardiovascular depression associated with induction of anesthesia, followed by respiratory causes (20%), and medication causes (20%). The incidence of mortality and neurological injury within the first 24h after the cardiac arrest was 0.92 and 1.38 per 10,000, respectively. The mortality in the first 3 months was 1.6 per 10,000. The main causes of death were ASA≥III, age under one year, pulmonary arterial hypertension, cardiac arrest in areas remote from the surgery area, a duration of cardiopulmonary resuscitation over 20min, and when hypothermia was not applied after cardiac arrest.
  
  
  CONCLUSIONS
  The main risk factors for cardiac arrest were ASA≥III, age under one year, emergency procedures, cardiology procedures and procedures performed in the catheterization laboratory. The main cause of the cardiac arrest was due mainly to cardiovascular hypovolemia. All patients who died or had neurological injury were ASA≥III. Pulmonary arterial hypertension is a risk of anesthesia-related mortality.
authors.affiliation: Servicios de Anestesia, Cuidados Críticos Quirúrgicos y Tratamiento del Dolor en Pediatría, Hospital Infantil Universitario La Paz, Madrid, España. Electronic address: psanabriacarretero@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Sanabria-Carretero
authors.forename: C
authors.initials: C
authors.lastname: Ochoa-Osorio
authors.forename: A
authors.initials: A
authors.lastname: Martín-Vega
authors.forename: A
authors.initials: A
authors.lastname: Lahoz-Ramón
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez-Pérez
authors.forename: F
authors.initials: F
authors.lastname: Reinoso-Barbero
authors.forename: L
authors.initials: L
authors.lastname: Goldman-Tarlovsky
mesh_terms: D000293:Adolescent; D000758:Anesthesia / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006323:Heart Arrest / Q000209:etiology*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D062606:Tertiary Care Centers
keywords: Anestesia; Anestesia pediátrica; Anesthesia; Cardiac arrest; Mortalidad; Mortality; Parada cardiaca; Pediatric anesthesia