title: Adsorptive stripping voltammetry determination of methyldopa on the surface of a carboxylated multiwall carbon nanotubes modified glassy carbon electrode in biological and pharmaceutical samples.
abstract: In the present work, a simple carboxylated multiwall carbon nanotubes (CMWCNTs) modified glassy carbon electrode was developed for sensitive determination of methyldopa (MTD). The study of modified electrode and MTD electrochemical behavior at its surface was investigated employing SEM, adsorptive stripping voltammetry, electrochemical impedance spectroscopy and chronocoulometry. These studies show that the oxidation of MTD is facilitated at the surface of GCE which is casted with CMWCNTs and remarkably peak current enhanced comparing to the bare electrode due to its adsorption on the electrode surface. Also, because of the catalytic property of modified electrode onset potential decreased for oxidation of MTD. Under optimized conditions, the calibration curve was linear in two concentration ranges of 0.1-30 and 30.0-300.0 μM with a detection limit of 0.08 μM and relative standard deviation (R.S.D.%) lower than 3.0% (n=5). This modified electrode was used as a sensor for determination of MTD in pharmaceutical and human urine samples with satisfactory results.
authors.affiliation: Department of Chemistry, Isfahan University of Technology, Isfahan, Islamic Republic of Iran. rezaei@cc.iut.ac.ir
authors.forename: Behzad
authors.initials: B
authors.lastname: Rezaei
authors.forename: Neda
authors.initials: N
authors.lastname: Askarpour
authors.forename: Ali A
authors.initials: AA
authors.lastname: Ensafi
mesh_terms: D000327:Adsorption; D002244:Carbon / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D055664:Electrochemical Techniques; D004566:Electrodes; D005898:Glass / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008750:Methyldopa / Q000032:analysis*; D008968:Molecular Conformation; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties
chemical_list: D002264:Carboxylic Acids; D037742:Nanotubes, Carbon; D008750:Methyldopa; D002244:Carbon