title: Tolosa-hunt syndrome associated with cytomegalovirus infection.
abstract: We herein present the case of a 38-year-old woman with left-sided oculomotor paralysis with ocular pain that developed after a respiratory infection. Her serum was positive for IgM against GM2 and GalNAc-GD1a gangliosides and cytomegalovirus. Thin-slice magnetic resonance imaging revealed enhanced abnormal tissue located primarily in the superolateral part of the left-sided cavernous sinus, which corticosteroids subsequently obscured with immediate resolution of the patient's ocular symptoms. These clinical features were consistent with those of Tolosa-Hunt syndrome (THS). Our findings in the present patient suggest that cytomegalovirus may provoke granuloma formation in the cavernous sinus, as reported in other various organs, thereby leading to the development of THS.
authors.affiliation: Department of Neurology, Akita University Graduate School of Medicine, Japan. sato@doc.med.akita-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okawa
authors.forename: Masashiro
authors.initials: M
authors.lastname: Sugawara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Otani
authors.forename: Manabu
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
authors.forename: Hirohide
authors.initials: H
authors.lastname: Ohnishi
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D002426:Cavernous Sinus / Q000821:virology; D003587:Cytomegalovirus / Q000276:immunology / Q000472:pathogenicity*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000276:immunology; D004172:Diplopia / Q000209:etiology; D005260:Female; D005677:G(M1) Ganglioside / Q000031:analogs & derivatives / Q000276:immunology; D005678:G(M2) Ganglioside / Q000276:immunology; D006099:Granuloma / Q000209:etiology / Q000821:virology; D006801:Humans; D021621:Imaging, Three-Dimensional; D007121:Immunocompetence; D007075:Immunoglobulin M / Q000097:blood; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D011239:Prednisolone / Q000627:therapeutic use; D012141:Respiratory Tract Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D020333:Tolosa-Hunt Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D001323:Autoantibodies; D007075:Immunoglobulin M; C064020:ganglioside GD1alpha; D005678:G(M2) Ganglioside; D005677:G(M1) Ganglioside; D011239:Prednisolone