title: Histone deacetylase (HDAC) inhibitors as single agents induce multiple myeloma cell death principally through the inhibition of class I HDAC.
authors.forename: Sridurga
authors.initials: S
authors.lastname: Mithraprabhu
authors.forename: Tiffany
authors.initials: T
authors.lastname: Khong
authors.forename: Simon S
authors.initials: SS
authors.lastname: Jones
authors.forename: Andrew
authors.initials: A
authors.lastname: Spencer
mesh_terms: D000107:Acetylation / Q000187:drug effects; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor / Q000187:drug effects / Q000201:enzymology; D047630:Depsipeptides / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology*; D006657:Histones / Q000378:metabolism; D006801:Humans; D006877:Hydroxamic Acids / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D009101:Multiple Myeloma / Q000201:enzymology / Q000473:pathology*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors*; D000077767:Panobinostat; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D011743:Pyrimidines / Q000494:pharmacology; D014404:Tubulin / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology
chemical_list: C583721:2-((1-(3-fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide; D000970:Antineoplastic Agents; D047630:Depsipeptides; D056572:Histone Deacetylase Inhibitors; D006657:Histones; D006877:Hydroxamic Acids; D007211:Indoles; C583720:N-hydroxy-2-(1-phenylcycloproylamino)pyrimidine-5-carboxamide; D009363:Neoplasm Proteins; D011743:Pyrimidines; D014404:Tubulin; D000077767:Panobinostat; C087123:romidepsin; C572255:ricolinostat
keywords: Class I HDAC; HDAC6; histone deacetylase inhibitors; multiple myeloma