title: Recapitulating atopic dermatitis in three dimensions: cross talk between keratinocytes and nerve fibers.
abstract: Roggenkamp et al. (2013) report a significant advance in the in vitro reconstruction of atopic dermatitis (AD) by coculturing lesional human keratinocytes with sensory nerve fibers. This work has important implications for understanding the interaction between the resident skin cells and the peripheral nervous system in AD, and it sheds light on the pathways leading to the pruritus that typifies this disease.
authors.affiliation: Institute of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Pincelli
authors.forename: Martin
authors.initials: M
authors.lastname: Steinhoff
mesh_terms: D003876:Dermatitis, Atopic / Q000378:metabolism* / Q000503:physiopathology*; D000078404:Epidermal Cells; D004817:Epidermis / Q000294:innervation*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology*; D009479:Neuropeptides / Q000378:metabolism*
chemical_list: D009479:Neuropeptides