title: A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope.
abstract: BACKGROUND
  MiroCam, a capsule endoscope, uses a novel transmission technology, electric-field propagation, which uses the human body as a conduction medium for data transmission.
  
  
  OBJECTIVE
  To compare the ability of the MiroCam (MC) and PillCam (PC) to identify sources of obscure GI bleeding (OGIB).
  
  
  METHODS
  Prospective, multicenter, comparative study.
  
  
  METHODS
  Six academic hospitals.
  
  
  METHODS
  A total of 105 patients with OGIB.
  
  
  METHODS
  Patients ingested both the MC and PC capsules sequentially in a randomized fashion.
  
  
  METHODS
  Concordance of rates in identifying a source of OGIB, operational times, and rates of complete small-bowel examination.
  
  
  RESULTS
  Data analysis resulted in 43 (48%) "abnormal" cases identifying a source of OGIB by either capsule. Twenty-four cases (55.8%) were positive by both capsules. There was negative agreement in 46 of 58 cases (79.3%). The κ index was 0.547 (χ(2) = 1.32; P = .36). In 12 cases, MC positively identified a source that was not seen on PC, whereas in 7 cases, PC positively identified a source that was not seen on MC. MC had a 5.6% higher rate of detecting small-bowel lesions (P = .54). MC captured images at 3 frames per second for 11.1 hours, and PC captured images at 2 frames per second for 7.8 hours (P < .0001). Complete small-bowel examination was achieved in 93.3% for MC and 84.3% for PC (P = .10).
  
  
  CONCLUSIONS
  Readers were not blinded to the particular capsule they were reading.
  
  
  CONCLUSIONS
  A positive diagnostic finding for OGIB was identified by either capsule in 48% of cases. The concordance rate between the 2 capsules was comparable to that of prior studies in identifying sources of small-bowel bleeding. The longer operational time of the MC may result in higher rates of complete small-bowel examination, which may, in turn, translate into a higher rate of detecting small-bowel lesions. (
  
  
  BACKGROUND
  NCT00878982.).
authors.affiliation: Division of Gastroenterology and Hepatology, Riverside Medical Clinic, Riverside, California, USA.
authors.forename: Eric H
authors.initials: EH
authors.lastname: Choi
authors.forename: Klaus
authors.initials: K
authors.lastname: Mergener
authors.forename: Carol
authors.initials: C
authors.lastname: Semrad
authors.forename: Laurel
authors.initials: L
authors.lastname: Fisher
authors.forename: David R
authors.initials: DR
authors.lastname: Cave
authors.forename: Milan
authors.initials: M
authors.lastname: Dodig
authors.forename: Carol
authors.initials: C
authors.lastname: Burke
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Leighton
authors.forename: David
authors.initials: D
authors.lastname: Kastenberg
authors.forename: Peter
authors.initials: P
authors.lastname: Simpson
authors.forename: James
authors.initials: J
authors.lastname: Sul
authors.forename: Kanishka
authors.initials: K
authors.lastname: Bhattacharya
authors.forename: Roger
authors.initials: R
authors.lastname: Charles
authors.forename: Lauren
authors.initials: L
authors.lastname: Gerson
authors.forename: Luke
authors.initials: L
authors.lastname: Weber
authors.forename: Glenn
authors.initials: G
authors.lastname: Eisen
authors.forename: Warren
authors.initials: W
authors.lastname: Reidel
authors.forename: John J
authors.initials: JJ
authors.lastname: Vargo
authors.forename: Jamile
authors.initials: J
authors.lastname: Wakim-Fleming
authors.forename: Simon K
authors.initials: SK
authors.lastname: Lo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053705:Capsule Endoscopes; D053704:Capsule Endoscopy / Q000379:methods*; D004867:Equipment Design; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis*; D006801:Humans; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D055815:Young Adult
keywords: CE; MC; MiroCam; OGIB; PC; PillCam; capsule endoscopy; obscure GI bleeding