title: Saving Implants BMP-2 Application in Revision Total Hip Surgery.
abstract: OBJECTIVE
  Besides others, there are two major problems in total hip replacement surgery which result in implant failure. First there is aseptic loosening due to a lack of implant biocompatibility or micromovements and second periimplant wear debris induced osteolysis which limits the survival rate of an implant. Regarding to recent data there are only limited therapeutic strategies to heal these bony defects without arthroplasty revision surgery. Since the investigation and characterization of adult mesenchymal stem cells (MSCs) from bone marrow, a cell and tissue engineering based therapy might be a promising solution to heal endoprosthesis associated bony defects. Moreover the application of growth factors in bone reconstructive surgery is another treatment concept to promote local bone regeneration.
  
  
  METHODS
  We report about a 73-year old patient with a painful weight bearing and a large, wear debris induced pelvic osteolysis after total hip arthroplasty. To prevent from salvage surgical procedures and preserve bone, a healing attempted was performed by filling the critical bony defect zone with a BMP-2/MSC composit.
  
  
  RESULTS
  Clinical and radiological follow-ups showed a progressive bony healing of the critical size defect area without any complications. Fifteen months after application the patient is still pain free, has no limitations in daily life or sport activities.
  
  
  CONCLUSIONS
  The case embarks on a strategy of non-embryonic stem cell and growth factor application to heal bony defects at patients with total hip endoprosthesis.
authors.affiliation: Department of Orthopedics, Heinrich-Heine University Hospital Dusseldorf (Director: Univ. Prof. Dr. med. R. Krauspe), Moorenstr. 5, D-40225 Dusseldorf, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Jäger
authors.forename: R
authors.initials: R
authors.lastname: Emami
authors.forename: F
authors.initials: F
authors.lastname: Thorey
authors.forename: R
authors.initials: R
authors.lastname: Krauspe
keywords: BMP; arthroplasty; bone defect; stem cells; total hip replacement