title: Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage.
abstract: Delayed cerebral vasospasm is a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). While the cellular mechanisms underlying vasospasm remain unclear, it is believed that inflammation may play a critical role in vasospasm. Matrix metalloproteinasees (MMPs) are a family of extracellular and membrane-bound proteases capable of degrading the blood-rain barrier (BBB). As such, MMP upregulation following SAH may result in a proinflammatory extravascular environment capable of inciting delayed cerebral vasospasm. This paper presents an overview of MMPs and describes existing data pertinent to delayed cerebral vasospasm.
authors.affiliation: Department of Neurosurgery, University of Southern California, 1200 North State Street, Suite 3300, Los Angeles, CA 90033, USA.
authors.forename: Vivek
authors.initials: V
authors.lastname: Mehta
authors.forename: Jonathan
authors.initials: J
authors.lastname: Russin
authors.forename: Alexandra
authors.initials: A
authors.lastname: Spirtos
authors.forename: Shuhan
authors.initials: S
authors.lastname: He
authors.forename: Peter
authors.initials: P
authors.lastname: Adamczyk
authors.forename: Arun P
authors.initials: AP
authors.lastname: Amar
authors.forename: William J
authors.initials: WJ
authors.lastname: Mack