title: Ponatinib in patients with refractory acute myeloid leukaemia: findings from a phase 1 study.
authors.forename: Neil P
authors.initials: NP
authors.lastname: Shah
authors.forename: Moshe
authors.initials: M
authors.lastname: Talpaz
authors.forename: Michael W N
authors.initials: MW
authors.lastname: Deininger
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Mauro
authors.forename: Ian W
authors.initials: IW
authors.lastname: Flinn
authors.forename: Dale
authors.initials: D
authors.lastname: Bixby
authors.forename: Stephanie
authors.initials: S
authors.lastname: Lustgarten
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Gozgit
authors.forename: Tim
authors.initials: T
authors.lastname: Clackson
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Turner
authors.forename: Frank G
authors.initials: FG
authors.lastname: Haluska
authors.forename: Hagop
authors.initials: H
authors.lastname: Kantarjian
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Cortes
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011724:Pyridazines / Q000627:therapeutic use*; D012008:Recurrence; D012074:Remission Induction; D016879:Salvage Therapy; D020080:Tandem Repeat Sequences; D051941:fms-Like Tyrosine Kinase 3 / Q000037:antagonists & inhibitors* / Q000235:genetics
chemical_list: D007093:Imidazoles; D009363:Neoplasm Proteins; D047428:Protein Kinase Inhibitors; D011724:Pyridazines; C545373:ponatinib; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3
keywords: FLT3 internal tandem duplications; FMS-like tyrosine kinase-3; acute myeloid leukaemia; ponatinib; tyrosine kinase inhibitor