title: [Glucose tolerance status and risk of dementia in the community: the Hisayama study].
abstract: The association between diabetes mellitus and the risk of developing dementia has received much attention in epidemiological studies. However, the results from these studies are still inconclusive. An accurate population-based prospective cohort study of dementia was begun in 1985 in the town of Hisayama, Japan. To examine the association between the glucose tolerance status and development of dementia, a total of 1,017 community-dwelling dementia-free subjects aged > or = 60 years who underwent a 75-g oral glucose tolerance test were followed up for 15 years. We demonstrated that people with diabetes were at an increasing risk of Alzheimer's disease (AD) and vascular dementia (VaD). Moreover, 2-hour post-load glucose levels were closely associated with an increased risk of AD and VaD, but no such associations were observed for fasting plasma glucose levels.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ohara
mesh_terms: D017677:Age Distribution; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications*; D001786:Blood Glucose / Q000032:analysis*; D015140:Dementia, Vascular / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D001786:Blood Glucose