title: Association between EXOC3L2 rs597668 polymorphism and Alzheimer's disease.
abstract: BACKGROUND
  EXOC3L2 gene rs597668 polymorphism was identified to be significantly associated with Alzheimer's disease (AD) in Caucasian population. However, recent studies reported consistent and inconsistent results in Caucasian and Asian populations.
  
  
  OBJECTIVE
  In order to assess this association, we performed a meta-analysis of rs597668 polymorphism using RevMan (v.5.1) software.
  
  
  METHODS
  We searched PubMed and Google scholar databases and selected 4 independent publications, which included 16 independent studies. We conducted sensitivity analysis and evaluated the publication bias. In the end, we calculated the odds ratio (OR) using fixed effect model (Mantel-Haenszel).
  
  
  RESULTS
  We observed significant association between rs597668 polymorphism and AD using allele model (P = 0.006, OR = 1.09, 95% CI 1.03-1.16) and the dominant model (P = 0.008, OR = 1.11, 95% CI 1.03-1.21).
  
  
  CONCLUSIONS
  To our knowledge, this is the first study that assesses the association between rs597668 polymorphism and AD by meta-analysis. We believe that our findings will be very useful for future genetic studies in AD.
authors.affiliation: Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Shang
authors.forename: Jin
authors.initials: J
authors.lastname: Fu
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: Song
authors.forename: Wei-Zhi
authors.initials: WZ
authors.lastname: Wang
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D033921:Vesicular Transport Proteins / Q000235:genetics*; D044465:White People / Q000208:ethnology / Q000235:genetics
chemical_list: C490685:EXOC3 protein, human; D033921:Vesicular Transport Proteins
keywords: Alzheimer's disease; Caucasian; EXOC3L2 rs597668 polymorphism; East Asian; Genome-wide association studies