title: The relationship between cerebrospinal fluid osteopontin level and central nervous system involvement in childhood acute leukemia.
abstract: The aim of this study was to evaluate the relationship between cerebrospinal fluid (CSF) osteopontin (OPN) levels and central nervous system (CNS) involvement in children with a diagnosis of acute leukemia. The study sample consisted of 62 patients who had been diagnosed with acute leukemia. The control group consisted of 16 patients that had presented and had no malignant disease, CNS infection or chronic disease. CSF OPN levels were studied with enzyme-linked immunosorbent assay (ELISA) method. The mean CSF OPN level was 32.76±49.22 ng/ml in the patients at the time of diagnosis and 14.93±6.84 ng/ml in the control group (p>0.05). The mean CSF OPN level was 27.68±32.73 ng/ml at the time of diagnosis in the group without CNS involvement and 53.48±89.21 ng/ml in the group with CNS involvement (p>0.05). However, the CSF OPN level at the time of CNS relapse in patients who developed CNS involvement during follow-up (127.4±52 ng/ml) was significantly higher than in the group without CNS involvement at diagnosis and follow-up (mean CSF OPN level: 27.68±32.73 ng/ml) (p<0.001). The analysis of CSF OPN levels at the time of diagnosis-before relapse and at the periods of relapse and remission in patients who had CNS involvement at diagnosis and/or follow-up revealed statistically significant differences between the time points (p<0.001). High CSF OPN levels in childhood acute leukemia patients may be used as evidence for CNS involvement, and any increases found in CSF OPN levels may be a preliminary predictor for CNS involvement.
authors.affiliation: Department of Pediatric Oncology, Dr. Sami Ulus Obstetrics and Pediatrics Training and Research Hospital, Ankara, Turkey. sincesoy@yahoo.co.uk
authors.forename: Sonay
authors.initials: S
authors.lastname: Incesoy-Özdemir
authors.forename: Gürses
authors.initials: G
authors.lastname: Sahin
authors.forename: Ceyhun
authors.initials: C
authors.lastname: Bozkurt
authors.forename: Ayşe Ceyda
authors.initials: AC
authors.lastname: Oren
authors.forename: Eda
authors.initials: E
authors.lastname: Balkaya
authors.forename: Ulya
authors.initials: U
authors.lastname: Ertem
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000134:cerebrospinal fluid; D016543:Central Nervous System Neoplasms / Q000134:cerebrospinal fluid*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D015456:Leukemia, Biphenotypic, Acute / Q000134:cerebrospinal fluid / Q000150:complications; D015470:Leukemia, Myeloid, Acute / Q000134:cerebrospinal fluid / Q000150:complications; D008297:Male; D009363:Neoplasm Proteins / Q000134:cerebrospinal fluid; D053495:Osteopontin / Q000134:cerebrospinal fluid*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid* / Q000150:complications; D011446:Prospective Studies; D012074:Remission Induction
chemical_list: D015415:Biomarkers; D009363:Neoplasm Proteins; D053495:Osteopontin