title: Dried apple enriched with mandarin juice counteracts tamoxifen-induced oxidative stress in rats.
abstract: The effect of a product made of dehydrated apples enriched with mandarin juice by vacuum impregnation on markers of oxidative stress (plasma antioxidant capacity, carbonyl groups (CGs), 8-hydroxydeoxyguanosine (8OHdG) and α-tocopherol) was tested in rats. Six groups of animals were studied: one group was fed a standard diet; two groups were supplemented with dehydrated apple either impregnated or not with mandarin juice throughout 28 days; and three groups (one unsupplemented and two supplemented) were additionally treated with tamoxifen (TAM) for 21 days used for induction of oxidative stress. The rats treated with TAM showed an increase in aminotransferases, CGs and 8OHdG. All of these effects were significantly decreased in the animals after apple snack consumption; the addition of mandarin juice into the apple mainly accounts for increased levels of α-tocopherol in plasma and liver. These findings suggest that the food product have a protective action against oxidative stress induced by TAM in rats.
authors.affiliation: Department of Pediatrics, Dr. Peset University Hospital , Valencia, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Codoñer-Franch
authors.forename: Ester
authors.initials: E
authors.lastname: Betoret
authors.forename: Ana B
authors.initials: AB
authors.lastname: López-Jaén
authors.forename: Noelia
authors.initials: N
authors.lastname: Betoret
authors.forename: Pedro
authors.initials: P
authors.lastname: Fito
authors.forename: Victoria
authors.initials: V
authors.lastname: Valls-Bellés
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D002957:Citrus; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood; D003890:Desiccation; D019587:Dietary Supplements; D005260:Female; D005638:Fruit; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D027845:Malus; D018384:Oxidative Stress / Q000187:drug effects*; D028321:Plant Preparations / Q000494:pharmacology*; D050050:Protein Carbonylation; D051381:Rats; D017208:Rats, Wistar; D062410:Snacks; D013629:Tamoxifen / Q000009:adverse effects*; D000637:Transaminases / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood / Q000378:metabolism
chemical_list: D000975:Antioxidants; D028321:Plant Preparations; D013629:Tamoxifen; D000080242:8-Hydroxy-2'-Deoxyguanosine; D000637:Transaminases; D003849:Deoxyguanosine; D024502:alpha-Tocopherol