title: Keratocyst of the buccal mucosa: case report and immunohistochemical comparative study with sporadic intraosseous keratocystic odontogenic tumor.
abstract: OBJECTIVE
  Describe a new case of keratocyst of the buccal mucosa and compare its immunohistochemical features with 13 sporadic intraosseous keratocystic odontogenic tumors (KOT).
  A male complaining about an enlargement on the left buccal mucosa was referred to the Stomatology Clinic. Clinical examination revealed a solitary nodule posterior to the parotid papilla. An excisional biopsy was performed following clinical diagnosis of epidermoid cyst. Microscopically, the lesion was characterized by a lining of five cell layers, with columnar basal cells and a corrugated parakeratinized surface. Immunohistochemical reactions for PTCH-1, Smo, Shh, mTOR, bcl-2, Ck17, and Ck19 were performed. PTCH-1 was not expressed in the keratocyst of the buccal mucosa, but was observed in suprabasal layers of eight (61.5%) cases of sporadic intraosseous KOT. Shh, mTOR, bcl-2, Ck17, and Ck19 expression was observed in all the cases investigated.
  
  
  CONCLUSIONS
  The morphology and immunoprofile of this lesion are similar to sporadic intraosseous KOT.
authors.affiliation: Professor, Discipline of Stomatology, Department of Biosciences and Oral Diagnosis. São José dos Campos Dental School, UNESP - Universidade Estadual Paulista, São Paulo, SP, Brazil. Electronic address: estela@fosjc.unesp.br.
authors.forename: E
authors.initials: E
authors.lastname: Kaminagakura
authors.forename: J D
authors.initials: JD
authors.lastname: Almeida
authors.forename: Y R
authors.initials: YR
authors.lastname: Carvalho
authors.forename: R C
authors.initials: RC
authors.lastname: Franco
authors.forename: F A
authors.initials: FA
authors.lastname: Soares
authors.forename: R M
authors.initials: RM
authors.lastname: Rocha
authors.forename: L P
authors.initials: LP
authors.lastname: Kowalski
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology*; D009807:Odontogenic Cysts / Q000473:pathology*; D009808:Odontogenic Tumors / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor