title: Ontogeny of the long form of leptin receptor gene expression in the porcine ovarian follicles.
abstract: Leptin is a polypeptide hormone produced predominantly in adipocytes. It has been found to be implicated in the regulation of satiety and energy homeostasis. A role for leptin in reproduction was later suggested by findings that this hormone may be involved in the regulation of the hypothalamic-pituitary-gonadal axis via endocrine, paracrine and/or autocrine pathways. The objective of the study was to investigate the ontogeny of the long isoform of leptin receptor (OB-Rb) gene in porcine ovarian follicles. The expression of OB-Rb gene was detected in porcine primordial, primary, secondary and antral follicles by in situ hybridization. In summary, our data suggest that leptin might have a direct effect on porcine follicles and plays an important role in the follicular development.
authors.affiliation: Department of Animal Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719 Olsztyn, Poland. nina.smolinska@uwm.edu.pl
authors.forename: N
authors.initials: N
authors.lastname: Smolinska
authors.forename: T
authors.initials: T
authors.lastname: Kaminski
authors.forename: G
authors.initials: G
authors.lastname: Siawrys
authors.forename: J
authors.initials: J
authors.lastname: Przala
mesh_terms: D000818:Animals; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D006080:Ovarian Follicle / Q000378:metabolism*; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D054411:Receptors, Leptin / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D013552:Swine / Q000378:metabolism*
chemical_list: D020033:Protein Isoforms; D012333:RNA, Messenger; D054411:Receptors, Leptin