title: Electrochemically controlled stiffness of multilayers for manipulation of cell adhesion.
abstract: Stimuli-responsive thin films attract considerable attention in different fields. Herein, an electrochemical redox multilayers with tunable stiffness is constructed through the layer-by-layer self-assembly method. The redox ferrocene modified poly(ethylenimine) play an essential role to induce multilayers' swelling/shrinking under an electrochemical stimulus, resulting reversible change of elastic modulus of the multilayers. The adhesion of fibroblast cells can be thus controlled from well spreading to round shape. Such soft multilayers with electrochemically controlled stiffness could have potentials for cell-based applications.
authors.forename: Yi-xin
authors.initials: YX
authors.lastname: Sun
authors.forename: Ke-feng
authors.initials: KF
authors.lastname: Ren
authors.forename: Jin-lei
authors.initials: JL
authors.lastname: Wang
authors.forename: Guo-xun
authors.initials: GX
authors.lastname: Chang
authors.forename: Jian
authors.initials: J
authors.lastname: Ji
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects*; D004563:Electrochemistry; D005296:Ferrous Compounds / Q000737:chemistry / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects*; D008567:Membranes, Artificial; D000075163:Metallocenes; D051379:Mice; D018625:Microscopy, Atomic Force; D041681:NIH 3T3 Cells; D011094:Polyethyleneimine / Q000737:chemistry / Q000494:pharmacology*; D058525:Quartz Crystal Microbalance Techniques
chemical_list: D005296:Ferrous Compounds; D008567:Membranes, Artificial; D000075163:Metallocenes; D011094:Polyethyleneimine; C004998:ferrocene