title: The presentation and management of mandibular tumors in the pediatric population.
abstract: OBJECTIVE
  To review the presentation and management of malignant tumors of the mandible in children.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Children 0 to 21 years old presenting to a tertiary pediatric hospital with a diagnosis of a malignant tumor involving the mandible were included. Comparison groups included children from the Surveillance, Epidemiology, and End Results database with malignant mandible tumors as well as a group of children with benign mandibular lesions from the same institution. Main outcome measures for the institutional malignant group included presentation, tumor characteristics, treatment modalities, and clinical outcome.
  
  
  RESULTS
  Sixteen patients with malignant and 183 patients with benign lesions were identified at the primary institution. The most common presentation in both groups was mandibular swelling or mass. Malignant tumors included sarcoma (n = 11), leukemia/lymphoma (n = 2), squamous cell carcinoma (n = 1), malignant spindle cell tumor (n = 1), and yolk sac tumor (n = 1). The national database identified 56 malignant cases, of which 71% were sarcomas. Thirteen patients at our institution (81%) underwent mandibulectomy and 12 were reconstructed using free tissue transfer. Eleven of the 13 (85%) were treated with adjuvant therapy. After an average follow-up of 32.8 months, seven (44%) had no evidence of disease, three (19%) were deceased, three (19%) were alive with disease, and three (19%) were lost to follow-up.
  
  
  CONCLUSIONS
  Malignant mandibular tumors in children are most often sarcomas but can include other rare lesions. Free flap reconstruction is a reasonable option for even very young children requiring extensive mandibular surgery.
authors.affiliation: Department of Otolaryngology, Strong Memorial Hospital, University of Rochester Medical Center, Rochester, New York 14642, USA. margo_benoit@urmc.rochester.edu
authors.forename: Margo McKenna
authors.initials: MM
authors.lastname: Benoit
authors.forename: Sara O
authors.initials: SO
authors.lastname: Vargas
authors.forename: Neil
authors.initials: N
authors.lastname: Bhattacharyya
authors.forename: Trevor A
authors.initials: TA
authors.lastname: McGill
authors.forename: Caroline D
authors.initials: CD
authors.lastname: Robson
authors.forename: Nalton
authors.initials: N
authors.lastname: Ferraro
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Didas
authors.forename: Brian I
authors.initials: BI
authors.lastname: Labow
authors.forename: Joseph
authors.initials: J
authors.lastname: Upton
authors.forename: Amir
authors.initials: A
authors.lastname: Taghinia
authors.forename: John G
authors.initials: JG
authors.lastname: Meara
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Marcus
authors.forename: Jennifer
authors.initials: J
authors.lastname: Mack
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodriguez-Galindo
authors.forename: Reza
authors.initials: R
authors.lastname: Rahbar
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008334:Mandible / Q000473:pathology* / Q000601:surgery; D008339:Mandibular Neoplasms / Q000473:pathology* / Q000601:surgery; D019651:Plastic Surgery Procedures / Q000379:methods*; D012509:Sarcoma / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult
keywords: Head and neck malignancy (pediatric); craniomaxillofacial surgery; mandible; mandibular reconstruction; microvascular reconstruction; pediatric cancer