title: NK/T-cell lymphoma of the nasal cavity causing contralateral dacryoadenitis.
abstract: OBJECTIVE
  To report a case of NK/T-cell lymphoma of the nasal cavity with contralateral lacrimal gland involvement.
  
  
  METHODS
  Observational case report.
  
  
  RESULTS
  A 39-year-old woman with a 5-month history of right fungal rhinosinusitis was referred to our hospital. A nasal mucosal biopsy performed before referral was consistent with Aspergillus sp. Despite surgical and parenteral antifungal treatment, the symptoms continued to deteriorate. On admission, the ophthalmic evaluation showed inflammation over the left lacrimal gland area. The fundus examination revealed bilateral subretinal infiltration. Computed tomography scans of the orbits and sinuses showed mucosal thickening of the right nasal mucosa and sinuses. There was heterogeneous enhancement and infiltration of the left lacrimal gland. Lacrimal gland biopsy and repeated biopsies of the nasal cavity and sinus tissue were performed. Immunohistopathology of the lacrimal glands and nasal mucosa showed extranodal nasal-type NK/T-cell lymphoma. The patient was treated with cyclophosphamide, vincristine, adriamycin, prednisolone (3 cycles), and intrathecal methotrexate. The patient developed sepsis and died 2 months after initiation of chemotherapy.
  
  
  CONCLUSIONS
  Dacryoadenitis can be a clinical manifestation of NK/T-cell lymphoma. To our knowledge, this is the first reported case of nasal NK/T-cell lymphoma with contralateral dacryoadenitis.
authors.affiliation: Department of Ophthalmology, Siriraj Hospital, Mahidol University, Bangkok, Thailand. paniteel@gmail.com
authors.forename: Panitee
authors.initials: P
authors.lastname: Luemsamran
authors.forename: Kanograt
authors.initials: K
authors.lastname: Pornpanich
authors.forename: Mongkol
authors.initials: M
authors.lastname: Uiprasertkul
authors.forename: Natta
authors.initials: N
authors.lastname: Sakolsatayadorn
authors.forename: Sumalee
authors.initials: S
authors.lastname: Vangveeravong
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000175:diagnosis*; D001706:Biopsy; D003607:Dacryocystitis / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000150:complications* / Q000175:diagnosis*; D009296:Nasal Cavity / Q000473:pathology*; D012852:Sinusitis / Q000382:microbiology*