title: Glomerulonephritis associated with tuberculosis: a case report and literature review.
abstract: Rapidly progressive glomerulonephritis caused mycobacterium tuberculosis is rare; however, three case have been reported to date. Crescentic glomerulonephritis is a life-threatening disease and together with the presence of tuberculous infection is associated with a poor outcome if treatment is inadequate and delayed. We describe the case of a 31-year-old female patient with nephrotic syndrome and progressive renal failure secondary to pulmonary tuberculosis. Renal biopsy showed crescent formation in 14 out of 27 glomeruli, and there was diffuse linear staining of immunoglobulin G deposits. Treatment included corticosteroids in combination with antituberculosis drugs for 2 months, and resulted in a significant improvement in renal function, the disappearance of proteinuria and pulmonary symptoms. We also present a review of the pertinent literature and discuss the pathophysiology of tuberculosis-related acute postinfectious glomerulonephritis.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Meram School of Medicine, Konya University, Meram, Konya, Turkey. yalcinsolakmd@gmail.com
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Solak
authors.forename: Abduzhappar
authors.initials: A
authors.lastname: Gaipov
authors.forename: Melih
authors.initials: M
authors.lastname: Anil
authors.forename: Huseyin
authors.initials: H
authors.lastname: Atalay
authors.forename: Orhan
authors.initials: O
authors.lastname: Ozbek
authors.forename: Kultigin
authors.initials: K
authors.lastname: Turkmen
authors.forename: Ilker
authors.initials: I
authors.lastname: Polat
authors.forename: Suleyman
authors.initials: S
authors.lastname: Turk
mesh_terms: D000328:Adult; D001706:Biopsy; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology*; D006760:Hospitalization; D006801:Humans; D007668:Kidney / Q000473:pathology; D013902:Radiography, Thoracic; D014376:Tuberculosis / Q000150:complications*