title: [Non-high-density-cholesterol as a predictor of non-lipid cardiovascular disease risk factors in obese children].
abstract: OBJECTIVE
  To investigate the role of non-high density lipoprotein cholesterol (non-HDL-C) in the assessment of cardiovascular disease (CVD) risk factors such as hypertension, pre-diabetes and diabetes in obese children.
  
  
  METHODS
  According to the presence of complications (hypertension, pre-diabetes and diabetes), 810 children with central obesity were divided into two groups: one group with complications (n=499) and one group without complications (n=311). One hundred and sixty-four age- and sex-matched children served as the control group. Logistic regression analysis and receiver operating characteristic (ROC) curves were used to analyze the detection of non-lipid CVD risk factors by seven lipid markers.
  
  
  RESULTS
  The prevalence rates of hypertension and pre-diabetes were significantly higher in obese children with high non-HDL-C concentrations (≥3.76 mmol/L). After adjusting for waist circumference Z-scores, the area under the ROC curve for non-HDL-C was 0.680 to detect non-lipid CVD risk factors, while the areas for low-density lipoprotein cholesterol, total cholesterol and apoprotein B were 0.659, 0.669 and 0.647 respectively.
  
  
  CONCLUSIONS
  Compared with the other lipid markers, non-HDL-C is a better predictor for non-lipid CVD risk factors in obese children. Measurement of non-HDL-C concentations is recommended for obese children.
authors.affiliation: Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Lian-Hui
authors.initials: LH
authors.lastname: Chen
authors.forename: Wei-Fen
authors.initials: WF
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Liang
authors.forename: Jun-Fen
authors.initials: JF
authors.lastname: Fu
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Wang
authors.forename: Yan-Lan
authors.initials: YL
authors.lastname: Fang
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D002318:Cardiovascular Diseases / Q000209:etiology*; D002648:Child; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications*; D012307:Risk Factors
chemical_list: D008076:Cholesterol, HDL; D002784:Cholesterol