title: Kinase AKT controls innate immune cell development and function.
abstract: The critical roles of kinase AKT in tumour cell proliferation, apoptosis and protein synthesis have been widely recognized. But AKT also plays an important role in immune modulation. Recent studies have confirmed that kinase AKT can regulate the development and functions of innate immune cells (neutrophil, macrophage and dendritic cell). Studies have shown that different isoforms of kinase AKT have different effects in regulating immunity-related diseases, mainly through the mammalian target of rapamycin-dependent or -independent pathways. The purpose of this review is to illustrate the immune modulating effects of kinase AKT on innate immune cell development, survival and function.
authors.affiliation: Department of Immunology, Shanghai Medical College, Fudan University, Shanghai, China; Shenyang Agriculture University, Shenyang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Huanrong
authors.initials: H
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Lu
authors.forename: Limei
authors.initials: L
authors.lastname: Han
authors.forename: Guangwei
authors.initials: G
authors.lastname: Liu
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D051057:Proto-Oncogene Proteins c-akt / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D051057:Proto-Oncogene Proteins c-akt
keywords: homeostasis; immunity; innate immunity; kinase AKT; modulation; molecular mechanisms