title: [Current state and vision of the development of new antipsychotic drugs].
abstract: To date, antipsychotic drugs have been developed mainly by targeting dopamine D2 receptors. No significant changes have occurred in this trend despite mental disorders being treated more frequently with so-called "atypical" antipsychotic drugs. The action of antipsychotic drugs on dopamine D2 receptors can play an important role in the development of future antipsychotic drugs. However, there is a growing trend of developing new antipsychotic drugs by targeting new pathways. In this article, we discuss the vision for future antipsychotic drugs through an increase in the number of new antipsychotic drugs that are currently being developed or are already on international markets.
authors.affiliation: Department of Neuropsychiatry, Kansai Medical University.
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Takekita
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kinoshita
mesh_terms: D014150:Antipsychotic Agents / Q000737:chemistry / Q000627:therapeutic use*; D055808:Drug Discovery / Q000639:trends; D015507:Drugs, Investigational / Q000627:therapeutic use*; D005544:Forecasting; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*; D017448:Receptors, Dopamine D2 / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; D015507:Drugs, Investigational; D017448:Receptors, Dopamine D2