title: [Epidemiology of febrile neutropenia in adult patients with hematologic neoplasms in a period of 26 months in Hospital Pablo Tobón Uribe, Colombia].
abstract: BACKGROUND
  Febrile neutropenia (FN) is a significant adverse effect post-chemotherapy due to its high morbidity and mortality. There are few studies in our country with these kind of patients.
  
  
  OBJECTIVE
  To describe the characteristics and mortality in patients with hematologic neoplasms who developed FN post-chemotherapy.
  
  
  METHODS
  A descriptive case series in patients with hematologic neoplasms who developed FN post-chemotherapy in Hospital Pablo Tobón Uribe.
  
  
  RESULTS
  101 episodes of FN in 43 patients. The median age was 44 years. 63.5% of patients had no apparent clinical focus of infection at admission, 11.8% had soft tissue compromise and 8.9% urinary tract infection. Bacteremia was documented in 41.5% and catheter-associated bacteremia in 3.9%. The most common organisms were Escherichia coli 43.4%, Klebsiella pneumoniae 17.3% and Staphylococcus aureus 8.6%. Of those isolated in blood 84.7% were Gram negative rods and 15.2% were Gram positive bacteria. Piperacillin/tazobactam was the most common empirically prescribed antibiotic (81.1%). Mortality of FN episodes occurred in 8 (7.92%) patients, 5 (62.5%) attributable to infection and 3 (37.5%) due to progression of hematologic malignancy with a resolution of FN.
  
  
  CONCLUSIONS
  In our case series of FN the microbiological characteristics differed significantly from developed countries, but a similar mortality rate per episode was observed.
authors.affiliation: Facultad de Medicina, Universidad Pontificia Bolivariana, Medellín, Colombia. camilomadrid@yahoo.com
authors.forename: Camilo
authors.initials: C
authors.lastname: Madrid
authors.forename: Laura
authors.initials: L
authors.lastname: Díaz
authors.forename: Juan
authors.initials: J
authors.lastname: Combariza
authors.forename: Kenny
authors.initials: K
authors.lastname: Gálvez
authors.forename: Viviana
authors.initials: V
authors.lastname: Olaya
authors.forename: Isabel
authors.initials: I
authors.lastname: Ramírez
authors.forename: Jorge
authors.initials: J
authors.lastname: Donado
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000453:epidemiology*; D003105:Colombia / Q000453:epidemiology; D005260:Female; D005334:Fever / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D019337:Hematologic Neoplasms / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D000970:Antineoplastic Agents