title: MicroRNAs in myeloid malignancies.
abstract: MicroRNAs (miRNAs) are key to the pathogenesis of human malignancies and increasingly recognized as potential biomarkers and therapeutic targets. Haematological malignancies, being the earliest human malignancies linked to aberrant miRNA expression, have consistently underpinned our understanding of the role that miRNAs play in cancer development. Here, we review the expanding roles attributed to miRNAs in the pathogenesis of different types of myeloid malignancies and highlight key findings.
authors.affiliation: Gene & Stem Cell Therapy Program, Centenary Institute, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
authors.forename: Jane E A
authors.initials: JE
authors.lastname: Gordon
authors.forename: Justin J-L
authors.initials: JJ
authors.lastname: Wong
authors.forename: John E J
authors.initials: JE
authors.lastname: Rasko
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009196:Myeloproliferative Disorders / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: acute myeloid leukaemia; chronic myeloid leukaemia; leukaemia; microRNAs; myeloid