title: Total synthesis of jadomycins B, S, T, and ILEVS1080.
abstract: Sweetening up jadomycin A: The first total synthesis of jadomycins B, S, T, and ILEVS1080 has been achieved, featuring construction of the unique 8H-benz[b]oxazolo[3,3-f]phenanthridine skeleton by biomimetic condensation of a quinone aldehyde with amino acid sodium salts and elaboration of the glycosides by Mitsunobu condensation (see figure).
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, PR China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Yang
authors.forename: Biao
authors.initials: B
authors.lastname: Yu
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D007532:Isoleucine / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D009005:Monosaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D009285:Naphthoquinones / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; C519266:ILEVS1080; D007546:Isoquinolines; D009005:Monosaccharides; D009285:Naphthoquinones; C506597:jadomycin A; C587310:jadomycin S; C587309:jadomycin T; D007532:Isoleucine; C081750:jadomycin B