title: TRO19622 promotes myelin repair in a rat model of demyelination.
abstract: OBJECTIVE
  Multiple sclerosis is a neurodegenerative autoimmune disease characterized by diffuse oligodendrocyte injury, axonal loss and multifocal demyelination of myelin sheaths in the central nervous system. TRO19622 is a small cholesterol-like compound, which displays remarkable neuroprotective and neuroregenerative properties in neural cell culture and rodent models of nerve trauma. Therefore, the aim of the present study is to evaluate the pharmacological action of TRO19622 on the demyelination/remyelination processes by using a rat model of cuprizone-induced demyelination.
  
  
  METHODS
  Using Female Sprague-Dawley rats models of demyelination, we morphologically and functionally assessed the effect of TRO19622 on myelination in vivo.
  
  
  RESULTS
  In this study, we first provided in vivo proof that cuprizone intoxication contributed to spatial learning and memory ability injury and that TRO19622 restored neurological function. The structure of myelin injury and repair in cuprizone intoxication rats was then measured by T2-weighted magnetic resonance imaging. These magnetic resonance imaging-based results and trends were confirmed by histological, immunohistochemistry and electron microscopy analyses.
  
  
  CONCLUSIONS
  The results clearly showed that TRO19622 promoted myelin formation with consequent functional improvement.
authors.affiliation: 1Central Laboratory, Ningbo Beilun People Hospital , People's Republic of China.
authors.forename: Yiqiao
authors.initials: Y
authors.lastname: Li
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Weiwei
authors.initials: W
authors.lastname: Han
authors.forename: Fengyin
authors.initials: F
authors.lastname: Hu
authors.forename: Yu'e
authors.initials: Y
authors.lastname: Qian
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D002783:Cholestenones / Q000627:therapeutic use*; D003711:Demyelinating Diseases / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002783:Cholestenones; C522838:olesoxime