title: Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology.
abstract: Advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed by the Maillard chemical process of non- enzymatic glycation of free amino groups of proteins, lipids and nucleic acids. This chemical modification of biomolecules is triggered by endogeneous hyperglycaemic or oxidative stress-related processes. Additionally, AGEs can derive from exogenous, mostly diet-related, sources. Considering that AGE accumulation in tissues correlates with ageing and is a hallmark in several age-related diseases it is not surprising that the role of AGEs in ageing and pathology has become increasingly evident. The receptor for AGEs (RAGE) is a single transmembrane protein being expressed in a wide variety of human cells. RAGE binds a broad repertoire of extracellular ligands and mediates responses to stress conditions by activating multiple signal transduction pathways being mostly responsible for acute and/or chronic inflammation. RAGE activation has been implicated in ageing as well as in a number of age-related diseases, including atherosclerosis, neurodegeneration, arthritis, stoke, diabetes and cancer. Here we present a synopsis of findings that relate to AGEs-reported implication in cell signalling pathways and ageing, as well as in pathology. Potential implications and opportunities for translational research and the development of new therapies are also discussed.
authors.affiliation: Institute for the Application of Nuclear Energy, University of Belgrade, Serbia.
authors.forename: O
authors.initials: O
authors.lastname: Nedić
authors.forename: S I S
authors.initials: SI
authors.lastname: Rattan
authors.forename: T
authors.initials: T
authors.lastname: Grune
authors.forename: I P
authors.initials: IP
authors.lastname: Trougakos
mesh_terms: D000375:Aging / Q000378:metabolism / Q000473:pathology; D050197:Atherosclerosis / Q000378:metabolism / Q000503:physiopathology; D017127:Glycation End Products, Advanced / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D008024:Ligands; D018384:Oxidative Stress; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D017127:Glycation End Products, Advanced; D008024:Ligands