title: Identification of micromonolactam, a new polyene macrocyclic lactam from two marine Micromonospora strains using chemical and molecular methods: clarification of the biosynthetic pathway from a glutamate starter unit.
abstract: Through a combination of chemical and molecular analysis, a new polyene macrolactam named micromonolactam was obtained from two marine-derived Micromonospora species. This new polyene metabolite is a constitutional isomer of salinilactam A but contains a different polyene pattern and one cis double bond, in contrast to the all trans structure reported for salinilactam A. The molecular analysis data also established that micromonolactam is a hybrid polyketide derived from 11 polyketide units and a modified glutamate starter unit.
authors.affiliation: Center for Marine Science, UNC Wilmington, Wilmington, NC, USA.
authors.forename: Elizabeth Julia
authors.initials: EJ
authors.lastname: Skellam
authors.forename: Allison Kathleen
authors.initials: AK
authors.lastname: Stewart
authors.forename: Wendy Karen
authors.initials: WK
authors.lastname: Strangman
authors.forename: Jeffrey Lawson Cameron
authors.initials: JL
authors.lastname: Wright
mesh_terms: D059001:Aquatic Organisms / Q000737:chemistry / Q000378:metabolism; D053898:Biosynthetic Pathways / Q000235:genetics*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D018698:Glutamic Acid / Q000378:metabolism; D047029:Lactams, Macrocyclic / Q000032:analysis* / Q000737:chemistry; D008847:Micromonospora / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011090:Polyenes / Q000032:analysis* / Q000737:chemistry; D017422:Sequence Analysis, DNA
chemical_list: D004269:DNA, Bacterial; D047029:Lactams, Macrocyclic; D011090:Polyenes; D018698:Glutamic Acid