title: Catalytic decarboxylative fluorination for the synthesis of tri- and difluoromethyl arenes.
abstract: Treatment of readily available α,α-difluoro- and α-fluoroarylacetic acids with Selectfluor under Ag(I) catalysis led to decarboxylative fluorination. This operationally simple reaction gave access to tri- and difluoromethylarenes applying a late-stage fluorination strategy. Translation to [(18)F]labeling is demonstrated using [(18)F]Selectfluor bis(triflate), a reagent affording [(18)F]tri- and [(18)F]difluoromethylarenes not within reach with [(18)F]F2.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mizuta
authors.forename: Ida S R
authors.initials: IS
authors.lastname: Stenhagen
authors.forename: Miriam
authors.initials: M
authors.lastname: O'Duill
authors.forename: Jamie
authors.initials: J
authors.lastname: Wolstenhulme
authors.forename: Anna K
authors.initials: AK
authors.lastname: Kirjavainen
authors.forename: Sarita J
authors.initials: SJ
authors.lastname: Forsback
authors.forename: Matthew
authors.initials: M
authors.lastname: Tredwell
authors.forename: Graham
authors.initials: G
authors.lastname: Sandford
authors.forename: Peter R
authors.initials: PR
authors.lastname: Moore
authors.forename: Mickael
authors.initials: M
authors.lastname: Huiban
authors.forename: Sajinder K
authors.initials: SK
authors.lastname: Luthra
authors.forename: Jan
authors.initials: J
authors.lastname: Passchier
authors.forename: Olof
authors.initials: O
authors.lastname: Solin
authors.forename: Véronique
authors.initials: V
authors.lastname: Gouverneur
mesh_terms: D002384:Catalysis; D003979:Diazonium Compounds / Q000737:chemistry*; D005462:Fluorine Radioisotopes; D054879:Halogenation; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure; D012834:Silver / Q000737:chemistry
chemical_list: D003979:Diazonium Compounds; D005462:Fluorine Radioisotopes; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D012834:Silver; C408750:selectfluor