title: Low-frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) reverses Aβ(1-42)-mediated memory deficits in rats.
abstract: Accumulating evidence shows the disruption of hippocampal neurotrophins secretion leads to memory deficits in Alzheimer's disease (AD) animal models. Invasive injection of exogenous neurotrophins into hippocampus reverses spatial memory deficits, but its clinical application is limited by traumatic brain injury during the injection procedure. Notably, recent studies have demonstrated that noninvasive repetitive transcranial magnetic stimulation (rTMS) increases endogenous neurotrophins contents in the brain of normal rats. Whether low-frequency rTMS can reverse Aβ(1-42)-mediated decrease in hippocampal neurotrophins contents and spatial memory impairment is still unclear. Here, we reported that severe deficit in long-term potentiation (LTP) and spatial memory were observed in an Aβ(1-42)-induced toxicity rat model. Furthermore, neurotrophins (NGF and BDNF) and NMDA-receptor levels were decreased after Aβ injection. However, low-frequency rTMS markedly reversed the decrease in neurotrophins contents. And the rTMS-induced increment of neurotrophins up-regulated hippocampal NMDA-receptor expression. Moreover, low-frequency rTMS rescued deficits in LTP and spatial memory of rats with Aβ-injection. These results indicate that low-frequency rTMS noninvasively and effectively increases hippocampal neurotrophins and NMDA-receptor contents in Aβ(1-42)-induced toxicity model rats, which helps to enhance hippocampal LTP and reverses Aβ(1-42)-mediated memory deficits.
authors.affiliation: School of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Tan
authors.forename: Jiacun
authors.initials: J
authors.lastname: Xie
authors.forename: Tiaotiao
authors.initials: T
authors.lastname: Liu
authors.forename: Xiaojia
authors.initials: X
authors.lastname: Chen
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zheng
authors.forename: Zhiqian
authors.initials: Z
authors.lastname: Tong
authors.forename: Xin
authors.initials: X
authors.lastname: Tian
mesh_terms: D016229:Amyloid beta-Peptides / Q000009:adverse effects*; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced* / Q000378:metabolism / Q000628:therapy*; D023421:Models, Animal; D020932:Nerve Growth Factor / Q000378:metabolism; D010446:Peptide Fragments / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
chemical_list: D016229:Amyloid beta-Peptides; D019208:Brain-Derived Neurotrophic Factor; D010446:Peptide Fragments; D016194:Receptors, N-Methyl-D-Aspartate; C075222:amyloid beta-protein (1-42); D020932:Nerve Growth Factor
keywords: Alzheimer's disease (AD); Brain-derived neurotrophic factor (BDNF); Long-term potentiation (LTP); NMDA receptor; Nerve growth factor (NGF); Repetitive transcranial magnetic stimulation (rTMS)