title: Risk factors of superimposed preeclampsia in women with essential chronic hypertension treated before pregnancy.
abstract: OBJECTIVE
  To determine risk factors of superimposed preeclampsia in women with essential chronic hypertension receiving antihypertensive therapy prior to conception.
  
  
  METHODS
  A retrospective study of 211 patients that analyzed risk factors of superimposed preeclampsia at first prenatal visit. Variables with a p<.1 at univariate analysis were included in a logistic regression analysis. P<.05 was considered as significant.
  
  
  RESULTS
  Superimposed preeclampsia occurred in 49 (23.2%) women. In logistic regression analysis, previous preeclampsia [OR: 4.05 (1.61-10.16)], and mean arterial blood pressure of 95 mmHg or higher [OR: 4.60 (1.94-10.93)] were associated with increased risk of superimposed preeclampsia. When both variables were present, sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratio for superimposed preeclampsia were 43%, 94%, 70%, 85%, and 7.71 (95% CI: 3.20-18.57), respectively.
  
  
  CONCLUSIONS
  In essential chronic hypertensive women, previous preeclampsia and mean arterial blood pressure of 95 mmHg or higher are associated with increased risks of superimposed preeclampsia.
authors.affiliation: University Paris 12, CHI Creteil, Creteil, France.
authors.forename: Edouard
authors.initials: E
authors.lastname: Lecarpentier
authors.forename: Vassilis
authors.initials: V
authors.lastname: Tsatsaris
authors.forename: François
authors.initials: F
authors.lastname: Goffinet
authors.forename: Dominique
authors.initials: D
authors.lastname: Cabrol
authors.forename: Baha
authors.initials: B
authors.lastname: Sibai
authors.forename: Bassam
authors.initials: B
authors.lastname: Haddad
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D011225:Pre-Eclampsia / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy; D011256:Pregnancy Outcome; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents; D001241:Aspirin