title: Radio-UHPLC: a tool for rapidly determining the radiochemical purity of technetium-99m radiopharmaceuticals?
abstract: Determining the radiochemical purity (RCP) of technetium-99m ((99m)Tc) radiopharmaceuticals using the method described in the package insert is a time-consuming process, requiring particular attention in order to achieve accurate RCP results. The purpose of this study was to evaluate whether radio-ultra high performance liquid chromatography (radio-UHPLC) may be an alternative method for RCP testing of (99m)Tc-tetrofosmin, (99m)Tc-MAG3 and (99m)Tc-sestamibi. Results obtained using radio-UHPLC were in excellent agreement with the standard method, with total analysis time being reduced to less than 3 min.
authors.affiliation: LPMCL UMR 5620 CNRS-Université Claude Bernard Lyon 1, Villeurbanne, France. david.kryza@chu-lyon.fr
authors.forename: David
authors.initials: D
authors.lastname: Kryza
authors.forename: Marc
authors.initials: M
authors.lastname: Janier
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods; D004340:Drug Contamination / Q000517:prevention & control*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008832:Microchemistry / Q000295:instrumentation* / Q000379:methods; D019275:Radiopharmaceuticals / Q000032:analysis* / Q000737:chemistry*; D013667:Technetium / Q000032:analysis* / Q000737:chemistry*
chemical_list: D019275:Radiopharmaceuticals; D013667:Technetium