title: High-resolution computed tomography and health-related quality of life in Mycobacterium avium complex disease.
abstract: METHODS
  Kyoto, Japan.
  
  
  OBJECTIVE
  To validate the St George's Respiratory Questionnaire (SGRQ) in pulmonary Mycobacterium avium-intracellulare complex disease and to analyse the significance of high-resolution computed tomography (HRCT) findings as determinants of health-related quality of life (HRQoL) after adjusting for clinical and physiological parameters.
  
  
  METHODS
  Eighty-five patients completed the SGRQ, pulmonary function tests and other patient-reported measurements. HRCT findings were assessed using an established computed tomography (CT) scoring method.
  
  
  RESULTS
  The SGRQ was validated with good internal consistency, test-retest reliability and significant correlations with most physiological variables and other patient-reported measurements. White blood cell counts, C-reactive protein levels, sputum culture results, treatment history, total CT scores, and consolidation, cavity and lobar volume-decrease CT component scores were significantly correlated with the SGRQ total and component scores. Stepwise multiple regression analyses revealed that the consolidation, cavity and lobar volume-decrease component scores were correlated with the SGRQ total and/or component scores. The total CT scores had the strongest relationships with the SGRQ total scores among the various clinical parameters tested, including microbiological, radiological, physiological and laboratory findings (32.8% of variance).
  
  
  CONCLUSIONS
  HRCT findings, particularly consolidation, cavity and lobar volume-decreases, were the most significant clinical parameters related to patient HRQoL.
authors.affiliation: Department of Respiratory Medicine, Kyoto University, Kyoto, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Maekawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Oga
authors.forename: T
authors.initials: T
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: S
authors.initials: S
authors.lastname: Imai
authors.forename: A
authors.initials: A
authors.lastname: Niimi
authors.forename: K
authors.initials: K
authors.lastname: Chin
authors.forename: S
authors.initials: S
authors.lastname: Ichiyama
authors.forename: K
authors.initials: K
authors.lastname: Togashi
authors.forename: M
authors.initials: M
authors.lastname: Mishima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D007564:Japan; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015270:Mycobacterium avium-intracellulare Infection / Q000503:physiopathology*; D011446:Prospective Studies; D011788:Quality of Life; D012044:Regression Analysis; D015203:Reproducibility of Results; D012129:Respiratory Function Tests; D013183:Sputum / Q000382:microbiology; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D002097:C-Reactive Protein