title: Langerhans cell sarcoma in two young children: imaging findings on initial presentation and recurrence.
abstract: Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells with malignant cytological features and multi-organ involvement that typically has a poor prognosis. We experienced 2 cases of LCS in children less than 2 years of age and report them based primarily on CT and MR findings. Both children had findings of hepatosplenomegaly with low-attenuation nodular lesions, had multiple lymphadenopathy, and had shown recurrent lesions invading the skull during follow-up after chemotherapy.
authors.affiliation: Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.
authors.forename: Woong Do
authors.initials: WD
authors.lastname: Chung
authors.forename: Soo Ah
authors.initials: SA
authors.lastname: Im
authors.forename: Nak Gyun
authors.initials: NG
authors.lastname: Chung
authors.forename: Gyeong Sin
authors.initials: GS
authors.lastname: Park
mesh_terms: D005260:Female; D006529:Hepatomegaly / Q000175:diagnosis; D006801:Humans; D007223:Infant; D054752:Langerhans Cell Sarcoma / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008479:Mediastinal Neoplasms / Q000175:diagnosis*; D009364:Neoplasm Recurrence, Local; D012888:Skull Neoplasms / Q000175:diagnosis*; D013163:Splenomegaly / Q000175:diagnosis; D014057:Tomography, X-Ray Computed
keywords: CT; Langerhans cell histiocytosis; Langerhans cell sarcoma; MR