title: Honokiol dimers and magnolol derivatives with new carbon skeletons from the roots of Magnolia officinalis and their inhibitory effects on superoxide anion generation and elastase release.
abstract: Two honokiol dimers, houpulins A and B (1 and 2), and two magnolol derivatives, houpulins C and D (3 and 4), were isolated and characterized from an ethanol extract obtained from the roots of Magnolia officinalis. The chemical structures were determined based on spectroscopic and physicochemical analyses, which included 1D and 2D NMR, as well as mass spectrometry data. These four oligomers possess new carbon skeletons postulated to be biosynthesized from the coupling of three or four C6-C3 subunits. In addition, the new oligomers were evaluated for inhibition of superoxide anion generation and elastase release, and houpulin B (2) was identified as a new anti-inflammatory lead compound.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Hung-Cheng
authors.initials: HC
authors.lastname: Shih
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Hung-Chung
authors.initials: HC
authors.lastname: Chen
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.forename: E-Jian
authors.initials: EJ
authors.lastname: Lee
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry / Q000494:pharmacology*; D002244:Carbon / Q000737:chemistry; D019281:Dimerization; D000431:Ethanol / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D031566:Magnolia / Q000737:chemistry*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010196:Pancreatic Elastase / Q000378:metabolism*; D018517:Plant Roots / Q000737:chemistry*; D013481:Superoxides / Q000378:metabolism*; D055815:Young Adult; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001713:Biphenyl Compounds; D002244:Carbon; D000431:Ethanol; D017705:Lignans; D010196:Pancreatic Elastase; D013481:Superoxides; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols