title: In vitro catheter and sorbent-based method for clearance of radiocontrast material during cerebral interventions.
abstract: BACKGROUND
  Contrast-induced acute kidney injury is a severe condition resulting from the use of radiology contrast in patients with predisposing factors.
  
  
  OBJECTIVE
  We hypothesized that a novel system including a device containing polymer resin sorbent beads and a custom-made suctioning catheter could efficiently remove contrast from an in vitro novel model of circulatory system (MOCS) mimicking the cerebral circulation.
  
  
  METHODS
  A custom-made catheter was built and optimized for cerebral venous approach. The efficiency of a system made of a polymer resin sorbent beads column (CST 401, Cytosorbents) and this particular catheter was tested in the MOCS running a solution composed of 0.9% saline and radio-contrast. During two series of 18 cycles of first-pass experiments we assessed the catheter's suctioning efficiency and the system's ability to clear radio-contrast injected into the MOCS's cerebral arterial segment. We also assessed the functioning and reliability of the MOCS.
  
  
  RESULTS
  Mean suctioning efficiency of the catheter was 84% ± 24%. The polymer sorbent column contrast removal rate was initially 96% and gradually decreased with subsequent cycles in a linear fashion during an experiment lasting approximately 90 minutes. The MOCS had a reliability of 0.9946×min(-1) where 1 × min(-1) was the optimum value.
  
  
  CONCLUSIONS
  A system including a polymer resin sorbent beads column and a custom-made suctioning catheter had an excellent initial efficiency in quickly removing contrast from an artificial MOCS mimicking the cerebral circulation. MOCS is an inexpensive and relatively reliable custom-made system that can be used for training or testing purposes.
authors.affiliation: Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. goangheloiu@drmc.org
authors.forename: George O
authors.initials: GO
authors.lastname: Angheloiu
authors.forename: Heribert
authors.initials: H
authors.lastname: Hänscheid
authors.forename: Christoph
authors.initials: C
authors.lastname: Reiners
authors.forename: William D
authors.initials: WD
authors.lastname: Anderson
authors.forename: John A
authors.initials: JA
authors.lastname: Kellum
mesh_terms: D002404:Catheterization / Q000295:instrumentation* / Q000379:methods; D057785:Catheters; D003287:Contrast Media; D006801:Humans; D008955:Models, Cardiovascular; D011108:Polymers; D015203:Reproducibility of Results; D013396:Suction / Q000295:instrumentation / Q000379:methods
chemical_list: D003287:Contrast Media; D011108:Polymers
keywords: Catheter; Contrast; MOCS; Nephropathy; Sorbent