title: Characterization of the temporo-parietal junction by combining data-driven parcellation, complementary connectivity analyses, and functional decoding.
abstract: The right temporo-parietal junction (RTPJ) is consistently implicated in two cognitive domains, attention and social cognitions. We conducted multi-modal connectivity-based parcellation to investigate potentially separate functional modules within RTPJ implementing this cognitive dualism. Both task-constrained meta-analytic coactivation mapping and task-free resting-state connectivity analysis independently identified two distinct clusters within RTPJ, subsequently characterized by network mapping and functional forward/reverse inference. Coactivation mapping and resting-state correlations revealed that the anterior cluster increased neural activity concomitantly with a midcingulate-motor-insular network, functionally associated with attention, and decreased neural activity concomitantly with a parietal network, functionally associated with social cognition and memory retrieval. The posterior cluster showed the exact opposite association pattern. Our data thus suggest that RTPJ links two antagonistic brain networks processing external versus internal information.
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-2), Research Center Jülich, Jülich, Germany; Jülich Aachen Research Alliance (JARA) - Translational Brain Medicine, Aachen, Germany; Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
authors.forename: Danilo
authors.initials: D
authors.lastname: Bzdok
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-2), Research Center Jülich, Jülich, Germany; Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Langner
authors.affiliation: Max-Planck-Institute for Neurological Research, Cologne, Germany; Dept. of Psychiatry, University of Cologne, Cologne, Germany.
authors.forename: Leonhard
authors.initials: L
authors.lastname: Schilbach
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-2), Research Center Jülich, Jülich, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Jakobs
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-2), Research Center Jülich, Jülich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Roski
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-2), Research Center Jülich, Jülich, Germany.
authors.forename: Svenja
authors.initials: S
authors.lastname: Caspers
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Angela R
authors.initials: AR
authors.lastname: Laird
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA; South Texas Veterans Administration Medical Center, San Antonio, TX, USA.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-2), Research Center Jülich, Jülich, Germany; Jülich Aachen Research Alliance (JARA) - Translational Brain Medicine, Aachen, Germany; C. & O. Vogt Institute of Brain Research, University of Düsseldorf, Düsseldorf, Germany.
authors.forename: Karl
authors.initials: K
authors.lastname: Zilles
authors.affiliation: Institute of Neuroscience and Medicine (INM-1, INM-2), Research Center Jülich, Jülich, Germany; Jülich Aachen Research Alliance (JARA) - Translational Brain Medicine, Aachen, Germany; Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany. Electronic address: S.Eickhoff@fz-juelich.de.
authors.forename: Simon B
authors.initials: SB
authors.lastname: Eickhoff
mesh_terms: D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000033:anatomy & histology; D010296:Parietal Lobe / Q000033:anatomy & histology*; D012919:Social Behavior; D013702:Temporal Lobe / Q000033:anatomy & histology*
keywords: Anti-correlation; Attention; Connectivity-based parcellation; Social cognition; Temporo-parietal junction