title: Efficacy and safety of computer-assisted stereotactic transplantation of human retinal pigment epithelium cells in the treatment of Parkinson disease.
abstract: OBJECTIVE
  This study explores the efficacy and safety of computer-assisted stereotactic transplantation of human retinal pigment epithelium (hRPE) cells in the treatment of Parkinson disease (PD).
  
  
  METHODS
  Guided by computed tomography and magnetic resonance imaging image mergence, we transplanted 4 × 10 hRPE cells into the putamina and lateral ventricles of 17 PD cases by stereotactic surgery. The transplantation site was located in the contralateral side of the symptoms and signs.
  
  
  RESULTS
  At 3 months after operation, the effective rates of cell transplantation were 82.4% in the contralateral site and 64.7% in the ipsilateral site. Minority of the cases had mild dizziness and hemiparesis, but the durations were short.
  
  
  CONCLUSIONS
  Computer-assisted stereotactic transplantation of hRPE for the treatment of PD is safe and efficient.
authors.affiliation: Department of Neurology, Yishui Central Hospital, Shandong, China. yzplcn@126.com
authors.forename: Yanzhong
authors.initials: Y
authors.lastname: Xue
authors.forename: Xiuxiu
authors.initials: X
authors.lastname: Li
authors.forename: Shouliang
authors.initials: S
authors.lastname: Pang
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Wang
authors.forename: Jinguo
authors.initials: J
authors.lastname: Yao
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zhou
authors.forename: Peilai
authors.initials: P
authors.lastname: Hao
mesh_terms: D000328:Adult; D000368:Aged; D017690:Cell Transplantation / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D053783:Magnetic Resonance Imaging, Interventional; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000601:surgery*; D011183:Postoperative Complications; D015641:Radiography, Interventional; D055213:Retinal Pigment Epithelium / Q000166:cytology* / Q000637:transplantation*; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed