title: Endothelial dysfunction in patients with type 2 diabetes post acute coronary syndrome.
abstract: This single visit study examined whether endothelial function, in addition to cardiovascular (CV) risk factors and plasma microparticle content, was normalised in 15 patients with type 2 diabetes + acute coronary syndrome (ACS) (6 weeks-6 months post cardiac event) undergoing standard clinical care compared to 16 sex- and age-matched healthy controls.
  
  
  RESULTS
  While total and low-density lipoprotein (LDL) cholesterol levels were well controlled in the patients with type 2 diabetes + ACS, residual CV risk profiles such as increased body mass index (BMI), systolic blood pressure, glucose levels and triglycerides and lower high-density lipoprotein (HDL) levels were still apparent. Endothelium-dependent responses to acetylcholine (ACh) were significantly lower in type 2 diabetes + ACS patients compared to controls. Correspondingly, the reactive hyperaemic index (RHI) was lower in the patient cohort. Endothelial microparticle (EMP) levels (CD31(+), CD41(-)) were 40% lower in the patient cohort. Simultaneous analysis of platelet microparticle (PMP) levels (CD41(+)) showed no difference between cohorts.
  
  
  CONCLUSIONS
  Patients with type 2 diabetes suffering from recent ACS exhibit residual CV risk factors despite being on standard clinical care. In addition, these patients continue to present with endothelial dysfunction despite having lower levels of EMPs.
authors.affiliation: Vascular Pharmacology and Heart Failure, Baker IDI Heart and Diabetes Institute, Melbourne, VIC, Australia.
authors.forename: Natalie G
authors.initials: NG
authors.lastname: Lumsden
authors.forename: Karen L
authors.initials: KL
authors.lastname: Andrews
authors.forename: Maria
authors.initials: M
authors.lastname: Bobadilla
authors.forename: Xiao L
authors.initials: XL
authors.lastname: Moore
authors.forename: Amanda K
authors.initials: AK
authors.lastname: Sampson
authors.forename: James A
authors.initials: JA
authors.lastname: Shaw
authors.forename: Jacques
authors.initials: J
authors.lastname: Mizrahi
authors.forename: David M
authors.initials: DM
authors.lastname: Kaye
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Dart
authors.forename: Jaye P F
authors.initials: JP
authors.lastname: Chin-Dusting
mesh_terms: D054058:Acute Coronary Syndrome / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D008078:Cholesterol, LDL
keywords: Type 2 diabetes; acute coronary syndrome; endothelial dysfunction; endothelial microparticles; peripheral arterial tonometry; plethysmography