title: Direct electron transfer between Cyt c and heme-Aβ relevant to Alzheimer's disease.
abstract: Partially reduced oxygen species (PROS), produced by reduced heme bound Aβ peptides, can cause oxidative stress and synaptic damage in the brain, which is one of the key pathological features of Alzheimer's disease. In situ oxidation of the heme center by a physiological redox agent like Cytochrome c (Cyt c) can significantly suppress neurotoxic PROS formation. Thus, Cyt c can potentially act as a neuroprotective agent against AD.
authors.affiliation: Indian Association for the Cultivation of Science, Department of Inorganic Chemistry, 2A & 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, India.
authors.forename: Chandradeep
authors.initials: C
authors.lastname: Ghosh
authors.forename: Soumya
authors.initials: S
authors.lastname: Mukherjee
authors.forename: Somdatta Ghosh
authors.initials: SG
authors.lastname: Dey
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D045304:Cytochromes c / Q000737:chemistry* / Q000378:metabolism; D004579:Electron Transport; D004583:Electrons; D006418:Heme / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D017382:Reactive Oxygen Species; D006418:Heme; D045304:Cytochromes c