title: A ratiometric naphthalimide sensor for live cell imaging of copper(I).
abstract: A new naphthalimide derivative bearing a tetrathia-azacrown for high affinity and selective binding to Cu(+) was synthesised. Copper recognition properties in solution were evaluated using (1)H NMR and fluorescence spectroscopy. Live cell imaging by confocal microscopy highlighted the capabilities of the new sensor for the two-wavelength detection of intracellular monovalent copper in neuronal cells.
authors.affiliation: Department of Chemical Sciences, University of Catania, viale Andrea Doria, 6, 95125 Catania, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Satriano
authors.forename: Giuseppe Trusso
authors.initials: GT
authors.lastname: Sfrazzetto
authors.forename: Maria Emanuela
authors.initials: ME
authors.lastname: Amato
authors.forename: Francesco P
authors.initials: FP
authors.lastname: Ballistreri
authors.forename: Agata
authors.initials: A
authors.lastname: Copani
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Giuffrida
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Grasso
authors.forename: Andrea
authors.initials: A
authors.lastname: Pappalardo
authors.forename: Enrico
authors.initials: E
authors.lastname: Rizzarelli
authors.forename: Gaetano A
authors.initials: GA
authors.lastname: Tomaselli
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Toscano
mesh_terms: D045744:Cell Line, Tumor; D003300:Copper / Q000032:analysis*; D006801:Humans; D018613:Microscopy, Confocal; D015394:Molecular Structure; D053644:Naphthalimides / Q000138:chemical synthesis / Q000737:chemistry*; D009474:Neurons / Q000737:chemistry* / Q000473:pathology
chemical_list: D053644:Naphthalimides; D003300:Copper