title: Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects.
abstract: It is known that adipose tissue mass increases with age, and that a number of hormones, collectively called adipokines, are produced by adipose tissue. For most of them it is not known whether their plasmatic levels change with age. Moreover, it is known that adipose tissue infiltration in skeletal muscle is related to sarcopenia and loss of muscle strength. In this study we investigated the age-related changes of representative adipokines and insulin-like growth factor (IGF)-1 and their effect on muscle strength. We studied the association between circulating levels of adiponectin, leptin, resistin and IGF-1 and muscle strength. This cross-sectional study included 412 subjects of different age (152 subjects aged 18-30 years and 260 subjects aged 69-81 years) recruited within the framework of the European research network project "Myoage". The levels of adiponectin (both in male and female subjects) and leptin (only in males) were significantly higher in old subjects compared to young, while those of IGF-1 were lower in old subjects. In old subjects adiponectin, resistin and the resistin/IGF-1 ratio (but not IGF-1 alone) were inversely associated with quadriceps torque, while only adiponectin was inversely associated with handgrip strength independently from percentage of fat mass, height, age, gender and geographical origin. The ratio of leptin to adiponectin was directly associated with handgrip strength in both young and old subjects. These results suggest that in humans the age-associated loss of strength is associated with the levels of representative adipokines and IGF-1.
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine and CIG-Interdepartmental Centre L. Galvani, University of Bologna, via S. Giacomo 12, 40126, Bologna, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Bucci
authors.forename: Stella Lukas
authors.initials: SL
authors.lastname: Yani
authors.forename: Cristina
authors.initials: C
authors.lastname: Fabbri
authors.forename: Astrid Y
authors.initials: AY
authors.lastname: Bijlsma
authors.forename: Andrea B
authors.initials: AB
authors.lastname: Maier
authors.forename: Carel G
authors.initials: CG
authors.lastname: Meskers
authors.forename: Marco V
authors.initials: MV
authors.lastname: Narici
authors.forename: David A
authors.initials: DA
authors.lastname: Jones
authors.forename: Jamie S
authors.initials: JS
authors.lastname: McPhee
authors.forename: Enn
authors.initials: E
authors.lastname: Seppet
authors.forename: Helena
authors.initials: H
authors.lastname: Gapeyeva
authors.forename: Mati
authors.initials: M
authors.lastname: Pääsuke
authors.forename: Sarianna
authors.initials: S
authors.lastname: Sipilä
authors.forename: Vuokko
authors.initials: V
authors.lastname: Kovanen
authors.forename: Lauri
authors.initials: L
authors.lastname: Stenroth
authors.forename: Antonio
authors.initials: A
authors.lastname: Musarò
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Hogrel
authors.forename: Yoann
authors.initials: Y
authors.lastname: Barnouin
authors.forename: Gillian
authors.initials: G
authors.lastname: Butler-Browne
authors.forename: Miriam
authors.initials: M
authors.lastname: Capri
authors.forename: Claudio
authors.initials: C
authors.lastname: Franceschi
authors.forename: Stefano
authors.initials: S
authors.lastname: Salvioli
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D020738:Leptin / Q000097:blood; D008297:Male; D053580:Muscle Strength / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D052243:Resistin / Q000097:blood; D015398:Signal Transduction / Q000502:physiology; D055815:Young Adult
chemical_list: D054392:Adipokines; D052242:Adiponectin; D020738:Leptin; D052243:Resistin; D007334:Insulin-Like Growth Factor I