title: The expression of IL-6 and STAT3 might predict progression and unfavorable prognosis in Wilms' tumor.
abstract: OBJECTIVE
  To investigate the expression profiles of IL-6 and STAT3 in Wilms' tumor (WT) and their relationship with disease progression.
  
  
  METHODS
  Immunohistochemistry was used to examine IL-6 and STAT3 expression in 58 primary tumors and 18 invasive/metastatic ones.
  
  
  RESULTS
  Positive expression rate of IL-6/STAT3 was 39.7% (23/58)/29.3% (17/58) in primary WT tissues, while 61.1% (11/18)/33.3% (6/18) in associated invasive/metastatic tissues. The expression rate of IL-6 and STAT3 was higher in primary WT tumors of invasive/metastatic group than that of non-invasive/metastatic group (P=0.033; P=0.012). There was a positive correlation between IL-6 and STAT3 expression in 76 WT tissues (P<0.001, r=0.444). The expression of IL-6 /STAT3 between primary WT and matched invasive/metastatic tissues was concordance (P=0.727; P=0.99). IL-6 expression status and histopathological type were associated with disease-free survival (DFS) and overall survival (OS) (P<0.05), while STAT3 was only correlated with DFS (P<0.05).
  
  
  CONCLUSIONS
  IL-6 and STAT3 expression in WT might be correlated with progression and predict unfavorable prognosis, highlighting a new therapy target for invasive or metastatic WTs.
authors.affiliation: Department of Pediatric Surgery, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, Shandong Province, PR China. shandazlj@163.com
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Ying-Mao
authors.initials: YM
authors.lastname: Gao
authors.forename: Ye-Jun
authors.initials: YJ
authors.lastname: Qin
authors.forename: Rong-De
authors.initials: RD
authors.lastname: Wu
mesh_terms: D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000096:biosynthesis / Q000235:genetics*; D007680:Kidney Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness / Q000235:genetics; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D050796:STAT3 Transcription Factor / Q000096:biosynthesis / Q000235:genetics*; D009396:Wilms Tumor / Q000235:genetics* / Q000473:pathology / Q000556:secondary
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human