title: Seroprevalence of antipolio antibodies among children <15 years of age in border provinces in China.
abstract: Despite remarkable progression toward polio eradication worldwide, wild poliovirus (WPV) importation has been a great challenge for China, as it shares borders with countries where WPV is endemic. The objective of this study was to estimate poliovirus antibody seroprevalence among children <15 years of age in 3 border provinces (Yunnan Province, Tibet Autonomous Region, and Xinjiang Uygur Autonomous Region) in China. A cross-sectional, hospital-based study was undertaken in 3 border provinces in 2010. Individuals <15 years old who visited hospitals at the prefecture level or above to have their blood drawn for any reason were invited to participate in our study. Neutralizing antibody titers to polio serotypes 1 (P1), P2, and P3 were assayed according to the World Health Organization manual for the virological investigation of polio. Antibody titers of ≥8 were considered positive. Among the 1,360 subjects enrolled, 1,220 (89.7%), 1,259 (92.6%), and 1,112 (81.8%) were seropositive to P1, P2, and P3, respectively, and 1,051 (77.3%) subjects were seropositive to all three serotypes. The highest seropositive rates were observed in Xinjiang Uygur Autonomous Region. By age, 3- to 5-year-old subjects had the highest rate of seropositivity, and seropositivity decreased significantly with increasing age. The risk of WPV importation will continue until WPV transmission has been interrupted worldwide. Consistent with the Global Polio Eradication Initiative's polio endgame strategy, China must maintain its polio-free status by ensuring adequate population immunity against polio. Because immunity wanes with increasing age, a booster dose with bivalent type 1 and 2 oral poliovirus vaccine could be considered for teenagers in China.
authors.affiliation: Chinese Center for Disease Control and Prevention, Xicheng District, Beijing, PR China.
authors.forename: HaiBo
authors.initials: H
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Cui
authors.forename: ZhenGrong
authors.initials: Z
authors.lastname: Ding
authors.forename: Pian
authors.initials: P
authors.lastname: Ba
authors.forename: ShuangLi
authors.initials: S
authors.lastname: Zhu
authors.forename: Ning
authors.initials: N
authors.lastname: Wen
authors.forename: LiXin
authors.initials: L
authors.lastname: Hao
authors.forename: Jing
authors.initials: J
authors.lastname: Ning
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: De
authors.initials: D
authors.lastname: Yang
authors.forename: WenBo
authors.initials: W
authors.lastname: Xu
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: ChunXiang
authors.initials: C
authors.lastname: Fan
authors.forename: WenZhou
authors.initials: W
authors.lastname: Yu
authors.forename: XiaoFeng
authors.initials: X
authors.lastname: Liang
authors.forename: HuiMing
authors.initials: H
authors.lastname: Luo
mesh_terms: D000293:Adolescent; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009500:Neutralization Tests; D017955:Poliovirus / Q000276:immunology*; D016036:Seroepidemiologic Studies
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral