title: [Severe delayed drug hypersensitivity reactions].
abstract: Although most delayed drug hypersensitivity reactions are mild and show rapid improvement after drug discontinuation, there are severe systemic and/or cutaneous drug reactions which may be life-threatening. These entities are discussed here, namely DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms), acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN). Early detection of warning signs and symptoms may help to take appropriate measures precociously.
authors.affiliation: Service d'Immunologie et d'Allergie, CHUV, 1011 Lausanne. christa-maria.maniu@chuv.ch
authors.forename: Christa-Maria
authors.initials: CM
authors.lastname: Maniu
authors.forename: Guillaume
authors.initials: G
authors.lastname: Buss
authors.forename: Laurence
authors.initials: L
authors.lastname: Feldmeyer
authors.forename: François
authors.initials: F
authors.lastname: Spertini
authors.forename: Camillo
authors.initials: C
authors.lastname: Ribi
mesh_terms: D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000628:therapy