title: The microRNA-148/152 family: multi-faceted players.
abstract: MicroRNAs(miRNA) are noncoding RNAs of about 19-23 nucleotides that are crucial for many biological processes. Members of the microRNA-148/152(miR-148/152) family, which include microRNA-148a(miR-148a), microRNA-148b(miR-148b), and microRNA-152(miR-152), are expressed differently in tumor and nontumor tissues and are involved in the genesis and development of disease. Furthermore, members of the miR-148/152 family are important in the growth and development of normal tissues. Members of the miR-148/152 family regulate target genes and are regulated by methylation of CPG islands. In this review, we report recent studies on the expression of members of the miR-148/152 family, methylation of CPG islands, and their target genes in different diseases, as well as in normal tissues.
authors.affiliation: Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, People's Republic of China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.forename: Yong-Xi
authors.initials: YX
authors.lastname: Song
authors.forename: Zhen-Ning
authors.initials: ZN
authors.lastname: Wang
mesh_terms: D019175:DNA Methylation; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D005810:Multigene Family; D009690:Nucleic Acid Conformation; D009928:Organ Specificity / Q000235:genetics
chemical_list: C550570:MIRN148 microRNA, human; C550856:MIRN152 microRNA, human; D035683:MicroRNAs