title: Many paths to alopecia via compromised regeneration of hair follicle stem cells.
abstract: Alopecia can be caused by defective formation, defective regeneration, or increased destruction of hair follicles. Much work has elucidated the roles of diffusible morphogens in modulating hair follicle stem cell activities. Recent studies have revealed novel molecular events within the nucleus, which are required for the activation and progression of hair stem cells. These studies will provide new clues and targets for designing therapeutic strategies for hair loss.
authors.affiliation: Department of Dermatology, XiangYa Hospital, Central South University, Changsha, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Li
authors.forename: Ting Xin
authors.initials: TX
authors.lastname: Jiang
authors.forename: Cheng Ming
authors.initials: CM
authors.lastname: Chuong
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000505:Alopecia / Q000235:genetics*; D000818:Animals; D018797:Cell Cycle Proteins; D000078404:Epidermal Cells; D004817:Epidermis / Q000254:growth & development*; D005260:Female; D008297:Male; D010750:Phosphoproteins / Q000235:genetics*; D013234:Stem Cells / Q000502:physiology*; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; D010750:Phosphoproteins; D000091102:YAP-Signaling Proteins; C486223:Yap1 protein, mouse