title: 5S rRNA: Structure and Function from Head to Toe.
abstract: 5S rRNA is uniquely positioned so as to link together all of the functional centers of the ribosome. Previous studies have supported the hypothesis that 5S rRNA acts as a physical transducer of information, facilitating communication between the different functional centers and coordinating of the multiple events catalyzed by the ribosome. Here, we present a synthesis of both structural and genetic information to construct a more detailed picture of how 5S rRNA may act to transmit and coordinate all of the functional centers of the ribosome.
authors.affiliation: Department of Chemistry, Moscow State University, Building A, Room 608, Vorobievy Gory, Moscow, Russia;
authors.forename: Olga A
authors.initials: OA
authors.lastname: Dontsova
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Dinman
keywords: 5S; Ribosome; fidelity; frameshifting; rRNA; translation; virus