title: Aceclofenac-induced acute tubulointerstitial nephritis in a patient with diabetes.
abstract: We describe a case of a 40-year-old lady diabetic and hypertensive, who presented with increasing fatigue and decreased physical endurance attributable to deterioration in renal function. The renal biopsy revealed drug-induced acute tubulointerstitial nephritis and the chronology of the events suggested the aetiology to be a recent intake of aceclofenac for knee pain. The patient improved with oral corticosteroids and the renal functions returned to baseline in 3 weeks. We did not come across a case of aceclofenac-induced acute tubulointerstitial nephritis on extensive electronic search of literature. This is probably the first case report of acute tubulointerstitial nephritis associated with the use of aceclofenac, a newer potent non-steroidal anti-inflammatory drug.
authors.affiliation: Department of Medicine, Government Medical College and Hospital, Chandigarh, India. monicamanish2001@gmail.com
authors.forename: Monica
authors.initials: M
authors.lastname: Gupta
authors.forename: Sanjay D
authors.initials: SD
authors.lastname: Cruz
authors.forename: Ritambhara
authors.initials: R
authors.lastname: Nada
authors.forename: Purnima
authors.initials: P
authors.lastname: Aggarwal
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D048909:Diabetes Complications; D003920:Diabetes Mellitus; D004008:Diclofenac / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000150:complications
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; C056498:aceclofenac