title: Association between MDM2 SNP309 T>G and risk of gastric cancer: a meta-analysis.
abstract: BACKGROUND
  As a negative regulator of P53, MDM2 plays an important role in carcinogenesis; a polymorphism in its promoter region. SNP309 T>G, is known to increase the expression of MDM2, thus being considered related to higher susceptibility to neoplasia. However, no agreement has been achieved regarding its effects on gastric cancer.
  
  
  METHODS
  The present systematic meta-analysis was performed based on comprehensive literature search from Pubmed, Web of science and CBM databases.
  
  
  RESULTS
  It was suggested from 6 independent studies that the GG genotype is associated with a significantly increased risk of gastric cancer (Recessive: OR = 1.43, 95% CI = 1.08-1.91, P = 0.013), and subgroup analysis also confirmed the relationship (English publications-recessive model: OR = 1.45, 95% CI = 1.10-1.91, P = 0.009; Studies in China-recessive model: OR = 1.58, 95% CI = 1.08-2.30, P = 0.017). No publication bias was detected.
  
  
  CONCLUSIONS
  The meta-analysis indicated a significant inverse association between GG genotype carriage and elevated risk of gastric cancer. However, more studies and detailed information are needed to fully address the topic.
authors.affiliation: Molecular Oncology Department of Cancer Research Institute, the First Affiliated Hospital, China Medical University, Shenyang, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Tian
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Ping
authors.initials: P
authors.lastname: Ma
authors.forename: Cheng-Guang
authors.initials: CG
authors.lastname: Sui
authors.forename: Fan-Dong
authors.initials: FD
authors.lastname: Meng
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Li-Ye
authors.initials: LY
authors.lastname: Fu
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Fu-Jian
authors.initials: FJ
authors.lastname: Ji
authors.forename: Xue-Dong
authors.initials: XD
authors.lastname: Fang
authors.forename: You-Hong
authors.initials: YH
authors.lastname: Jiang
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology*
chemical_list: C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2