title: Nitroglycerine and sodium trioxodinitrate: from the discovery to the preconditioning effect.
abstract: The history began in the 19th century with Ascanio Sobrero (1812-1888), the discoverer of glycerol trinitrate (nitroglycerine, NTG), and with Angelo Angeli (1864-1931), the discoverer of sodium trioxodinitrate (Angeli's salt). It is likely that Angeli and Sobrero never met, but their two histories will join each other more than a century later. In fact, it has been discovered that both NTG and Angeli's salt are able to induce a preconditioning effect. As NTG has a long history as an antianginal drug its newly discovered property as a preconditioning agent has also been tested in humans. Angeli's salt properties as a preconditioning and inotropic agent have only been tested in animals so far.
authors.affiliation: Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Torino, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Pagliaro
authors.forename: Donatella
authors.initials: D
authors.lastname: Gattullo
authors.forename: Claudia
authors.initials: C
authors.lastname: Penna
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000266:history / Q000378:metabolism / Q000627:therapeutic use*; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000266:history / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D009569:Nitric Oxide / Q000378:metabolism; D020030:Nitric Oxide Donors / Q000266:history / Q000378:metabolism / Q000627:therapeutic use*; D009573:Nitrites / Q000266:history / Q000378:metabolism / Q000627:therapeutic use*; D005996:Nitroglycerin / Q000266:history / Q000378:metabolism / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects; D014665:Vasodilator Agents / Q000266:history / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D002317:Cardiovascular Agents; D020030:Nitric Oxide Donors; D009573:Nitrites; D014665:Vasodilator Agents; C021229:oxyhyponitrite; D009569:Nitric Oxide; D005996:Nitroglycerin