title: Surgery and proton pump inhibitors for treatment of vocal process granulomas.
abstract: The aim of this study was to analyze the outcomes of vocal process granulomas treated with surgery and proton pump inhibitors and to specify related factors of recurrence. The medical records of patients with diagnosis of vocal process granuloma between 2000 and 2012 were reviewed. All patients were treated with surgery and proton pump inhibitors for at least 1 month. Forty-one patients were reviewed; mean follow-up time was 45 months. There was no recurrence among the patients who had a recent history of intubation. The recurrence rates of contact granuloma was 38.7 %, and significantly related to the frequency of surgery (P = 0.042), but was not significantly associated with the history of acid reflux (P = 0.676) and vocal abuse (P = 0.447), lesion size (P = 0.203) or surgical techniques (P = 0.331). Surgery combined with proton pump inhibitors was partially effective for the vocal process granulomas, especially with intubated patients. However, repeat surgery for recurrent contact granuloma should be preceded with caution due to high recurrence rates.
authors.affiliation: Department of Otolaryngology, Affiliated Eye and Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Fen-yang Road 83, Shanghai, China.
authors.forename: Duan
authors.initials: D
authors.lastname: Hong-Gang
authors.forename: Jin
authors.initials: J
authors.lastname: He-Juan
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chun-Quan
authors.forename: Fan
authors.initials: F
authors.lastname: Guo-Kang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy*; D006102:Granuloma, Laryngeal / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects; D007828:Laryngoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014827:Vocal Cords / Q000293:injuries / Q000601:surgery*; D055815:Young Adult
chemical_list: D054328:Proton Pump Inhibitors