title: Research development of the relationship between thymidine phosphorylase expression and colorectal carcinoma.
abstract: Thymidine phosphorylase (TP) is a key enzyme that contributes to the composition and decomposition of pyrimidine nucleotides. TP seems homologous to platelet-derived endothelial cell growth factor, and its effects on inducing vascularization and anti-apoptosis are closely related to growth and metastasis of colorectal carcinoma. In addition, TP is a key enzyme that catalyzes the transformation from 5-fluorouracil (FU) prodrugs of 5'-deoxy-5-fluorouridine (5'-DFUR) to 5-FU. The activity of TP is closely related to the sensitivity of colorectal carcinoma cells to fluorouracil drugs and targeted therapy. Given the important functions of TP in growth, metastasis, tumor treatment, and prognosis, determining its expression mechanism is significant. This article summarizes the research development of TP expression in colorectal carcinoma, tumor neovascularization, cytotoxicity activation of 5'-DFUR, and colorectal carcinoma therapy.
authors.affiliation: Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
authors.forename: Dian-Jun
authors.initials: DJ
authors.lastname: Ye
authors.forename: Ji-Min
authors.initials: JM
authors.lastname: Zhang
keywords: 5’-deoxy-5-fluorouridine; Thymidine phosphorylase; angiogenesis; colorectal carcinoma