title: Link between cancer and Alzheimer disease via oxidative stress induced by nitric oxide-dependent mitochondrial DNA overproliferation and deletion.
abstract: Nitric oxide- (NO-) dependent oxidative stress results in mitochondrial ultrastructural alterations and DNA damage in cases of Alzheimer disease (AD). However, little is known about these pathways in human cancers, especially during the development as well as the progression of primary brain tumors and metastatic colorectal cancer. One of the key features of tumors is the deficiency in tissue energy that accompanies mitochondrial lesions and formation of the hypoxic smaller sized mitochondria with ultrastructural abnormalities. We speculate that mitochondrial involvement may play a significant role in the etiopathogenesis of cancer. Recent studies also demonstrate a potential link between AD and cancer, and anticancer drugs are being explored for the inhibition of AD-like pathology in transgenic mice. Severity of the cancer growth, metastasis, and brain pathology in AD (in animal models that mimic human AD) correlate with the degree of mitochondrial ultrastructural abnormalities. Recent advances in the cell-cycle reentry of the terminally differentiated neuronal cells indicate that NO-dependent mitochondrial abnormal activities and mitotic cell division are not the only important pathogenic factors in pathogenesis of cancer and AD, but open a new window for the development of novel treatment strategies for these devastating diseases.
authors.affiliation: GALLY International Biomedical Research Consulting LLC, 7733 Louis Pasteur Drive, No. 328, San Antonio, TX 78229, USA. aliev03@gmail.com
authors.forename: Gjumrakch
authors.initials: G
authors.lastname: Aliev
authors.forename: Mark E
authors.initials: ME
authors.lastname: Obrenovich
authors.forename: Shams
authors.initials: S
authors.lastname: Tabrez
authors.forename: Nasimudeen R
authors.initials: NR
authors.lastname: Jabir
authors.forename: V Prakash
authors.initials: VP
authors.lastname: Reddy
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Burnstock
authors.forename: Ramon
authors.initials: R
authors.lastname: Cacabelos
authors.forename: Mohammad Amjad
authors.initials: MA
authors.lastname: Kamal
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology*; D000818:Animals; D004272:DNA, Mitochondrial / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D009569:Nitric Oxide / Q000378:metabolism*; D018384:Oxidative Stress; D017384:Sequence Deletion
chemical_list: D004272:DNA, Mitochondrial; D009569:Nitric Oxide