title: Dynamics of neurotransmitters in the structures of the rat jejunum during chronic alcohol intoxication.
abstract: We studied the effects of ethanol on bioamine-containing structures in the jejunum at different stages of alcohol intoxication. The content of catecholamines, serotonin, and histamine in enterocytes of the villus epithelium, submucosa mast cells, crypt enterocytes, and muscular layer was measured by luminescent microscopy and cytospectrofluorometry. Uneven increase of biogenic amine content was found in rats in the initial period of chronic alcohol intoxication (60 days). Further alcohol intake (up to 180 days) impaired the balance of biogenic amines; catecholamines started to prevail.
authors.affiliation: Department of General and Clinical Pathology with Forensic Medicine Course, I. N. Ulyanov Chuvash State University, Cheboksary, Russia. 28Lybov@mail.ru
authors.forename: L M
authors.initials: LM
authors.lastname: Yakovleva
authors.forename: L A
authors.initials: LA
authors.lastname: Lubovtseva
mesh_terms: D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D002395:Catecholamines / Q000032:analysis; D020895:Enterocytes; D000431:Ethanol / Q000494:pharmacology*; D006632:Histamine / Q000032:analysis; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D007583:Jejunum / Q000294:innervation* / Q000378:metabolism / Q000648:ultrastructure; D008407:Mast Cells; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000032:analysis
chemical_list: D002395:Catecholamines; D018377:Neurotransmitter Agents; D012701:Serotonin; D000431:Ethanol; D006632:Histamine