title: Bioinformatic analysis of functional proteins involved in obesity associated with diabetes.
abstract: The twin epidemic of diabetes and obesity pose daunting challenges worldwide. The dramatic rise in obesity-associated diabetes resulted in an alarming increase in the incidence and prevalence of obesity an important complication of diabetes. Differences among individuals in their susceptibility to both these conditions probably reflect their genetic constitutions. The dramatic improvements in genomic and bioinformatic resources are accelerating the pace of gene discovery. It is tempting to speculate the key susceptible genes/proteins that bridges diabetes mellitus and obesity. In this regard, we evaluated the role of several genes/proteins that are believed to be involved in the evolution of obesity associated diabetes by employing multiple sequence alignment using ClustalW tool and constructed a phylogram tree using functional protein sequences extracted from NCBI. Phylogram was constructed using Neighbor-Joining Algorithm a bioinformatic tool. Our bioinformatic analysis reports resistin gene as ominous link with obesity associated diabetes. This bioinformatic study will be useful for future studies towards therapeutic inventions of obesity associated type 2 diabetes.
authors.affiliation: International Center for Bioinformatics, Department of Computer Science and Systems Engineering, Andhra University, India;
authors.forename: Allam Appa
authors.initials: AA
authors.lastname: Rao
authors.forename: N Manga
authors.initials: NM
authors.lastname: Tayaru
authors.forename: Hanuman
authors.initials: H
authors.lastname: Thota
authors.forename: Suresh Babu
authors.initials: SB
authors.lastname: Changalasetty
authors.forename: Lalitha Saroja
authors.initials: LS
authors.lastname: Thota
authors.forename: Srinubabu
authors.initials: S
authors.lastname: Gedela
keywords: bioinformatics; obesity and type two diabetes; resistin