title: Bioactivity of selenium-enriched exopolysaccharides produced by Enterobacter cloacae Z0206 in broilers.
abstract: To investigate effects of Se-enriched exopolysaccharides (Se-ECZ-EPS) produced by Enterobacter cloacae Z0206 on growth performance, antioxidant status and immune function, 240 broilers were randomly assigned into five groups: the control group was fed a basal diet supplemented with 0.15 mg/kg Se (Na2SeO3), and the other four groups were fed with diets supplemented with Se-ECZ-EPS at 280, 560, 840 and 1120 mg/kg, respectively. Administration of Se-ECZ-EPS (840 and 1120 mg/kg) significantly increased average daily gain, decreased feed/gain ratio and enhanced antioxidant enzyme activities. Serum cytokine concentrations showed positive responses in birds treated with 560 and 1120 mg/kg Se-ECZ-EPS. Serum antibody titers against Newcastle disease virus in birds treated with 840 mg/kg Se-ECZ-EPS were significantly increased. These results suggested that Se-ECZ-EPS could enhance antioxidant status and immune function, and could be developed to a potentiator of the immune response in broilers, with the 840 mg/kg addition level being the most effective.
authors.affiliation: National Engineering Laboratory of Bio-feed Safety and Pollution Prevention, Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Institute of Feed Science, Zhejiang University, Hangzhou 310058, PR China.
authors.forename: Zeqing
authors.initials: Z
authors.lastname: Lu
authors.forename: Mingliang
authors.initials: M
authors.lastname: Jin
authors.forename: Ming
authors.initials: M
authors.lastname: Huang
authors.forename: Youming
authors.initials: Y
authors.lastname: Wang
authors.forename: Yizhen
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000975:Antioxidants / Q000494:pharmacology*; D002645:Chickens / Q000097:blood*; D016207:Cytokines / Q000097:blood; D016972:Enterobacter cloacae; D005979:Glutathione Peroxidase / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D009522:Newcastle disease virus / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D012643:Selenium / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D000975:Antioxidants; D016207:Cytokines; D011135:Polysaccharides, Bacterial; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium