title: Case report of a patient with schizophrenia and a mutation in the insulin receptor substrate-4 gene.
abstract: This report deals with a female patient with schizophrenia who was found to have a mutation in the insulin receptor substrate-4 gene that is located on chromosome Xq22.3. Since this mutation is expected to change amino acid coding from histidine to tyrosine and cause an altered insulin receptor substrate-4 protein, and the insulin receptor substrate-4 protein may be involved in neuronal growth and function in the brain, it is possible that it is this insulin receptor substrate-4 gene mutation that underlies this patient's schizophrenia development.
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Kristina.Melkersson@ki.se.
authors.forename: Kristina
authors.initials: K
authors.lastname: Melkersson
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D041321:Chromosomes, Human, X; D005260:Female; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D012563:Schizophrenia, Paranoid / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics
chemical_list: C107686:IRS4 protein, human; D055504:Insulin Receptor Substrate Proteins