title: Planning genomic study in an animal model of depression: a preliminary report.
abstract: BACKGROUND
  Interaction of several genes is responsible for psychiatric diseases such as depression. Despite the numerous microarray studies in this field, findings are controversial and hard to conclude.
  
  
  METHODS
  Male Wistar rats were randomly selected to receive Chronic Mild Stress model for 4 weeks. Different aspects of depression were measured by forced swimming test, open field trial and sucrose preference tests in the experience group and controls.
  
  
  RESULTS
  Sucrose was preferred by 40% of CMS group and 80% of controls (p=0.025). Twenty percent of CMS group and 80% of controls were "active" (p=0.001). Last escape was at minute 238 for CMS group and minute 245 for controls and controls had more escape efforts.
  
  
  CONCLUSIONS
  This paper is a preliminary report of a genomic study on animal model of depression which tries to achieve reliable results by a joint of clinical view with recent techniques. Predicted challenges in this procedure and the solutions as well as the limitations may be helpful for future researches.
authors.affiliation: Research Team for Psychiatry and Behavioral Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Farnam
authors.forename: Ali
authors.initials: A
authors.lastname: Fakhari
authors.forename: Leila
authors.initials: L
authors.lastname: Roshangar
authors.forename: Sajjad
authors.initials: S
authors.lastname: Kahni
authors.forename: Sara
authors.initials: S
authors.lastname: Farhang
keywords: Animal model; Chronic stress; Forced swimming; Major depression; Sucrose preference test