title: [Pharmacology and clinical implication of typical antipsychotics].
abstract: Typical antipsychotic drugs were introduced in 1950's. Atypical antipsychotics developed in 1990's and 2000's have been reported to show superiority over typical antipsychotics. However, when comparison was made with a low dose of a typical drug, the superiority disappeared in some studies. Both types of antipsychotics have in common a pharmacological property to decrease dopamine D2 receptor neurotransmission. Polypharmacy once prevailed in Japan and a high dose therapy once dominated in western countries should not be used anymore. The proper dose of typical antipsychotics is much lower than the dose used previously. Typical as well as atypical antipsychotics should be used as monotherapy with a proper dosage. It is of clinical significance for treatment staffs to become to pay more attention to quality of life and rehabilitation of patients.
authors.affiliation: Department of Psychiatry, School of Medicine, University of Tokushima.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohmori
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D007564:Japan; D017410:Practice Guidelines as Topic; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy*; D014481:United States
chemical_list: D014150:Antipsychotic Agents; D017448:Receptors, Dopamine D2; D004298:Dopamine