title: mTORC1 signaling aids in CADalyzing pyrimidine biosynthesis.
abstract: Mechanistic target of rapamycin complex 1 (mTORC1) regulates growth and metabolism by integrating signals from the cellular environment. Ben-Sahra et al. (2013) and Robitaille et al. (2013) demonstrate a role for mTORC1 in nucleotide production via S6K1 phosphorylation of CAD, which catalyzes the initial steps of de novo pyrimidine biosynthesis.
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Gwen R
authors.initials: GR
authors.lastname: Buel
authors.forename: Sang Gyun
authors.initials: SG
authors.lastname: Kim
authors.forename: John
authors.initials: J
authors.lastname: Blenis