title: Unbiased segregation of yeast chromatids in Saccharomyces cerevisiae.
abstract: The budding yeast Saccharomyces cerevisiae is characterized by asymmetric cell division and the asymmetric inheritance of spindle components during normal vegetative growth and during certain specialized cell divisions. There has been a longstanding interest in the possibility that yeast chromosomes segregate non-randomly during mitosis and that some of the differences between mother and daughter cells could be explained by selective chromatid segregation. This review traces the history of the experiments to determine if there is biased chromatid segregation in yeast. The special aspects of spindle morphogenesis and behavior in yeast that could accommodate a mechanism for biased segregation are discussed. Finally, a recent experiment demonstrated that yeast chromatids segregate randomly without mother-daughter bias in a common laboratory strain grown under routine laboratory conditions.
authors.affiliation: Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, The University of Virginia, Charlottesville, VA 22908-0733, USA. dburke@virginia.edu
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Burke
mesh_terms: D002842:Chromatids / Q000378:metabolism*; D020090:Chromosome Segregation; D008938:Mitosis; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics*