title: Effect of IKK-2 inhibitor on local Th1 and Th2 type inflammation.
abstract: We studied the capacity of IKK-2 inhibitor ([5-(p-fluorophenyl)-2-ureido] thiophene-3-carboxamide) and non-steroidal anti-inflammatory drug voltaren to reduce the severity of local inflammation in Th1- and Th2-type immune response. The test substances (inhibitor in concentrations from 2×10(-13)to 2×10(-16)M and 9.8×10(-4)M voltaren) were shown to reduce edema caused by sheep erythrocytes (Th1-type immune response) and local immediate-type hypersensitivity response (Th2-type immune response). The anti-inflammatory effects of IKK-2 inhibitor in Th1-type immune response were similar to those of voltaren.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Ligacheva
authors.forename: A N
authors.initials: AN
authors.lastname: Ivanova
authors.forename: Yu P
authors.initials: YP
authors.lastname: Belsky
authors.forename: N V
authors.initials: NV
authors.lastname: Belska
authors.forename: E S
authors.initials: ES
authors.lastname: Trofimova
authors.forename: M G
authors.initials: MG
authors.lastname: Danilets
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D004008:Diclofenac / Q000494:pharmacology*; D004487:Edema / Q000188:drug therapy; D005260:Female; D006968:Hypersensitivity, Delayed / Q000188:drug therapy* / Q000276:immunology; D006969:Hypersensitivity, Immediate / Q000188:drug therapy* / Q000276:immunology; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000378:metabolism; D010671:Phenylurea Compounds / Q000494:pharmacology*; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology*; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology*; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: C586469:(5-(p-fluorophenyl)-2-ureido)thiophene-3-carboxamide; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016328:NF-kappa B; D010671:Phenylurea Compounds; D013876:Thiophenes; D004008:Diclofenac; D051550:I-kappa B Kinase; C496562:Ikbkb protein, mouse