title: Association between GSTM1 and CYP1A1 polymorphisms and survival in oral cancer patients.
abstract: OBJECTIVE
  Cancer patient's inherited genotype may influence his or her survival, but evidence for the role of these genetic differences in oral cancer survival has not yet been explored.
  
  
  METHODS
  The authors evaluated polymorphisms in the GSTM1 and CYP1A1 genes for associations with overall survival in 100 oral squamous cell carcinoma (OSCC) treated patients and 100 controls who were followed up for survival within 2 years of the date of completion of their treatment. Overall survival was evaluated in Kaplan-Meier survival functions and Cox proportional hazards models.
  
  
  RESULTS
  After adjustment for stage and histology, GSTM1null genotype was associated with shorter survival among OSCC patients, compared with GSTM1 present genotype. There was no association between CYP1A1 C genotype and survival in the overall study population.
  
  
  CONCLUSIONS
  The study indicated a potential role for GSTM1 polymorphism in predicting the clinical outcomes of treated oral carcinoma patients.
authors.affiliation: Department of Oral Pathology and Microbiology, Faculty of Dentistry, Jamia Millia Islamia, Delhi, India.
authors.forename: Deepika
authors.initials: D
authors.lastname: Shukla
authors.forename: Alka
authors.initials: A
authors.lastname: Dinesh Kale
authors.forename: Seema
authors.initials: S
authors.lastname: Hallikerimath
authors.forename: Venkatakanthaiah
authors.initials: V
authors.lastname: Yerramalla
authors.forename: Vivekanandhan
authors.initials: V
authors.lastname: Subbiah
authors.forename: Shashwat
authors.initials: S
authors.lastname: Mishra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000401:mortality; D011110:Polymorphism, Genetic; D015996:Survival Rate; D055815:Young Adult
chemical_list: D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase