title: Cytotoxic 9,11-secosteroids from the South China Sea gorgonian Subergorgia suberosa.
abstract: Ten new 9,11-secosteroids, subergorgols A-J (1-10), including two pairs of epimers (3/4, and 6/7), along with three known analogues (11-13) were isolated from the South China Sea gorgonian Subergorgia suberosa. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses and comparison with the literature data. The cytotoxicities in vitro against three selected human tumor cell lines for all the compounds were evaluated. Compound 9 showed significant cytotoxicities toward both K562 and MDA-MB-231 cell lines with IC50 values of 5.5 and 6.2μM, respectively, and compound 10 also showed inhibitory activity against K562 cell line with an IC50 value of 6.5μM.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhang
authors.forename: Xuli
authors.initials: X
authors.lastname: Tang
authors.forename: Canling
authors.initials: C
authors.lastname: Cheng
authors.forename: Kaikai
authors.initials: K
authors.lastname: Gong
authors.forename: Xingwang
authors.initials: X
authors.lastname: Zhang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhu
authors.forename: Rongcui
authors.initials: R
authors.lastname: Wu
authors.forename: Pinglin
authors.initials: P
authors.lastname: Li
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Li
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002681:China; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009792:Oceans and Seas; D012632:Secosteroids / Q000737:chemistry / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D012632:Secosteroids; D012717:Sesquiterpenes
keywords: 9,11-Secosteroids; Cytotoxicity; Gorgonian; Structural identification; Subergorgia suberosa