title: Acute myelofibrosis and acute lymphoblastic leukemia in an elderly patient with previously treated multiple myeloma.
abstract: Multiple myeloma (MM) is a plasma cell neoplasm involving the bone marrow with organ damage and/or a monoclonal protein (M-spike in the serum and/or urine). This neoplasm typically affects adults over the age of 50. Acute lymphoblastic leukemia (ALL) is a hematological disorder involving at least 20% lymphoblasts in the bone marrow of the B-cell lineage. Acute lymphoblastic leukemia most commonly affects young children with 75% of cases occurring in children less than 6 years old. This case report describes a patient diagnosed with MM in 2000 who achieved a complete remission in 2006 after chemotherapy. Four years later, the patient presented with sudden pancytopenia. A bone marrow biopsy was obtained revealing a B lymphoblastic leukemia in an extensively fibrotic marrow without evidence of MM. A diagnosis of ALL with myelofibrosis is rare in the adult population, acute myelofibrosis (AMF) is more commonly associated with myeloproliferative disorders, and the development of acute leukemia in myeloma is rare. To the best of our knowledge, the presence of MM, ALL, and myelofibrosis in one patient has never been reported.
authors.affiliation: Department of Pathology, University of Texas Health Science Center at Houston, Houston, TX, USA. maria.m.gonzalezmendez@uth.tmc.edu
authors.forename: Maria M
authors.initials: MM
authors.lastname: Gonzalez
authors.forename: Laura
authors.initials: L
authors.lastname: Kidd
authors.forename: Jorge
authors.initials: J
authors.lastname: Quesada
authors.forename: Nghia
authors.initials: N
authors.lastname: Nguyen
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
mesh_terms: D000368:Aged; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D000077269:Lenalidomide; D060046:Maintenance Chemotherapy / Q000009:adverse effects; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology / Q000473:pathology*; D055728:Primary Myelofibrosis / Q000209:etiology / Q000473:pathology*; D013792:Thalidomide / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D013792:Thalidomide; D000077269:Lenalidomide