title: A randomised clinical trial to assess the effect of a dual treatment on myopia progression: the Cambridge Anti-Myopia Study.
abstract: OBJECTIVE
  To evaluate the effect of a dual treatment modality for myopia, by improving accommodative functions, on myopia progression.
  
  
  METHODS
  A double blind randomised control trial was conducted on 96 subjects. The treatment modality for the trial employed custom designed contact lenses which control spherical aberration in an attempt to optimise static accommodation responses during near-work, and a vision-training programme to improve accommodation dynamics. Myopia progression was assessed over a 2 year period using cycloplegic autorefraction and biometry.
  
  
  RESULTS
  The mean progression was found to be -0.33 Dioptres (D) over the 2 years of the study. There was no interaction between contact lens treatment and vision training treatment at 24 months (p = 0.72). There was no significant treatment effect of either Vision Training or Contact Lens Spherical Aberration control on myopia progression.
  
  
  CONCLUSIONS
  This study is unable to demonstrate that the progression of myopia can be reduced over a 2 year period by either of the two treatments aimed at improving accommodative function. Neither treatment group (contact lens or vision training) progressed at a slower rate over the 2 years of the study than did the appropriate control group.
authors.affiliation: Vision and Eye Research Unit, Department of Vision and Hearing Sciences, Postgraduate Medical Institute, Anglia Ruskin University, Cambridge, UK. peter.allen@anglia.ac.uk
authors.forename: Peter M
authors.initials: PM
authors.lastname: Allen
authors.forename: Hema
authors.initials: H
authors.lastname: Radhakrishnan
authors.forename: Holly
authors.initials: H
authors.lastname: Price
authors.forename: Sheila
authors.initials: S
authors.lastname: Rae
authors.forename: Baskar
authors.initials: B
authors.lastname: Theagarayan
authors.forename: Richard I
authors.initials: RI
authors.lastname: Calver
authors.forename: Ananth
authors.initials: A
authors.lastname: Sailoganathan
authors.forename: Keziah
authors.initials: K
authors.lastname: Latham
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: O'Leary
mesh_terms: D000065:Accommodation, Ocular / Q000502:physiology*; D000293:Adolescent; D000704:Analysis of Variance; D003131:Combined Modality Therapy; D003261:Contact Lenses; D057108:Corneal Wavefront Aberration / Q000503:physiopathology; D018450:Disease Progression; D004311:Double-Blind Method; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D009216:Myopia / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult