title: Mesoglycan treatment in Raynaud phenomenon: a case series.
abstract: OBJECTIVE
  Raynaud's phenomenon (RP) is a common clinical disorder without cure or gold standard therapy. Mesoglycan is an well-balanced extract of glycosaminoglycans active on endothelial layers at microcirculatory level. Herein we investigated for the first time the efficacy and tolerability of mesoglycan on vasospastic attacks and videocapillaroscopy patterns in 25 consecutive patients with primary or secondary RP.
  
  
  CONCLUSIONS
  During 12 months of add-on therapy, mesoglycan obtained a remarkable and significant reduction in the frequency of Raynaud attacks and an improvement of the capillaroscopy abnormalities in most patients, without important adverse effects, revealing a good convenience in the management if this condition.
authors.affiliation: Ambulatory of Vascular Diagnostic, Geriatric Medicine Villa Verde, Taranto, Italy. a.dibiase@email.it
authors.forename: A
authors.initials: A
authors.lastname: Di Biase
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005385:Fingers / Q000098:blood supply; D005500:Follow-Up Studies; D006025:Glycosaminoglycans / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D020678:Microscopic Angioscopy; D008875:Middle Aged; D010045:Outpatients; D011928:Raynaud Disease / Q000188:drug therapy*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D006025:Glycosaminoglycans; D014665:Vasodilator Agents; C040617:mesoglycan