title: [Expression of P38 MAPK and MMP-2 mRNA in neonatal rats with hyperoxia-induced lung injury].
abstract: OBJECTIVE
  To observe P38 mitogen-activated protein kinase (P38 MAPK) and matrix metalloproteinase-2 (MMP-2) mRNA expression level changes in neonatal rats with hyperoxia-induced lung injury,and to investigate the influence of P38 MAPK activation on MMP-2 mRNA expression.
  
  
  METHODS
  Thirty-six Sprague-Dawley (SD) rats were randomly divided into three groups: air control, hyperoxia and SB203580-treated hyperoxia (n=12). The rats were sacrificed on the 3rd and 7th days and the lungs were removed. Hematoxylin-eosine staining was used to observe the pathological changes in lung tissues.
  
  
  RESULTS
  Compared with the air and SB203580-treated groups, levels of P38 MAPK and MMP-2 mRNA significantly increased in the hyperoxia group (P<0.01).
  
  
  CONCLUSIONS
  Expression of P38 MAPK increases in neonatal rats with hyperoxia-induced acute lung injury and this may play a role in control of the expression of MMP-2 mRNA.
authors.affiliation: Department of Neonatology, Children's Hospital of Soochow University, Suzhou, Jiangsu 215003, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Pan
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Xiao
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005260:Female; D018496:Hyperoxia / Q000150:complications*; D008168:Lung / Q000473:pathology; D055370:Lung Injury / Q000378:metabolism*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019714:Tissue Inhibitor of Metalloproteinases / Q000235:genetics; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D019714:Tissue Inhibitor of Metalloproteinases; D048051:p38 Mitogen-Activated Protein Kinases; D020778:Matrix Metalloproteinase 2; C522363:Mmp2 protein, rat