title: ArtPathDesign: rational heterologous pathway design system for the production of nonnative metabolites.
abstract: In silico platform named ArtPathDesign was developed to design and select heterologous pathways. By integrating previously developed pathway search algorithm and scoring heterologous pathways using codon usage information, we successfully screened heterologous reactions suitable for the production of value-added chemicals by microorganisms.
authors.affiliation: Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Sunisa
authors.initials: S
authors.lastname: Chatsurachai
authors.forename: Chikara
authors.initials: C
authors.lastname: Furusawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimizu
mesh_terms: D000465:Algorithms; D003062:Codon / Q000235:genetics; D019295:Computational Biology; D003198:Computer Simulation; D004798:Enzymes / Q000235:genetics / Q000378:metabolism; D060847:Metabolic Engineering / Q000379:methods*; D053858:Metabolic Networks and Pathways / Q000235:genetics*
chemical_list: D003062:Codon; D004798:Enzymes
keywords: ArtPathDesign; Codon adaptation index; Heterologous enzymes; In silico platform; Metabolic pathway