title: The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function.
abstract: The cell-autonomous role of synaptic transmission in the regulation of neuronal structural and electrical properties is unclear. We have now employed a genetic approach to eliminate glutamatergic synaptic transmission onto individual CA1 pyramidal neurons in a mosaic fashion in vivo. Surprisingly, while electrical properties are profoundly affected in these neurons, as well as inhibitory synaptic transmission, we found little perturbation of neuronal morphology, demonstrating a functional segregation of excitatory synaptic transmission from neuronal morphological development.
authors.affiliation: Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Eric A
authors.initials: EA
authors.lastname: Bushong
authors.forename: Tiffany P
authors.initials: TP
authors.lastname: Shih
authors.forename: Mark H
authors.initials: MH
authors.lastname: Ellisman
authors.forename: Roger A
authors.initials: RA
authors.lastname: Nicoll
mesh_terms: D000200:Action Potentials / Q000235:genetics / Q000502:physiology; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D048430:Cell Shape / Q000235:genetics / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000235:genetics / Q000502:physiology*; D018698:Glutamic Acid / Q000502:physiology*; D051379:Mice; D018408:Patch-Clamp Techniques; D017966:Pyramidal Cells / Q000166:cytology / Q000502:physiology*; D013569:Synapses / Q000235:genetics / Q000502:physiology*; D009435:Synaptic Transmission / Q000235:genetics / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid