title: Moderate-intensity single exercise session does not induce renal damage.
abstract: BACKGROUND
  The aim of this study was to determine whether a single moderate-intensity exercise session induces renal injury based on various parameters that reflect kidney dysfunction, including urinary L-type fatty acid-binding protein (L-FABP).
  
  
  METHODS
  Adult outpatients (n = 31) with chronic kidney disease (CKD) not receiving renal replacement therapy participated in this study. Urine was collected before and after a single 20-min moderate-intensity exercise session. Urinary levels of L-FABP, albumin, N-acetyl-β-d-glucosaminidase (NAG), and α1-microglobrin (α1MG) were measured. In addition, 12 patients with estimated glomerular filtration fraction less than 30 ml/min/1.73 ml(2) were selected from all patients and evaluated using the same analysis.
  
  
  RESULTS
  Urinary values of L-FABP, albumin, NAG, and α1MG did not increase significantly after exercise compared with before exercise (urinary L-FABP, from 8.3 to 9.4 μg/g of creatinine; urinary albumin, from 293.1 to 333.7 mg/g of creatinine; urinary NAG, from 9.2 to 8.2 U/g of creatinine; urinary α1MG, from 11.4 to 9.8 mg/g of creatinine, not significant). Similar findings were seen in all patients, regardless of degree of renal dysfunction.
  
  
  CONCLUSIONS
  A single session of moderate-intensity exercise was not associated with an increase in renal parameters used to assess renal damage.
authors.affiliation: Department of Rehabilitation Medicine, St. Marianna University School of Medicine Hospital, Kanagawa, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Hiraki
authors.forename: Atsuko
authors.initials: A
authors.lastname: Kamijo-Ikemori
authors.forename: Takashi
authors.initials: T
authors.lastname: Yasuda
authors.forename: Chiharu
authors.initials: C
authors.lastname: Hotta
authors.forename: Kazuhiro P
authors.initials: KP
authors.lastname: Izawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Watanabe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sugaya
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kimura
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000368:Aged; D000510:Alpha-Globulins / Q000652:urine; D015415:Biomarkers / Q000652:urine*; D005080:Exercise Test / Q000009:adverse effects*; D050556:Fatty Acid-Binding Proteins / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology / Q000652:urine*; D018709:Statistics, Nonparametric; D016138:Walking / Q000502:physiology*
chemical_list: D000510:Alpha-Globulins; D015415:Biomarkers; C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins; D000118:Acetylglucosaminidase