title: Relating the bipolar spectrum to dysregulation of behavioural activation: a perspective from dynamical modelling.
abstract: Bipolar Disorders affect a substantial minority of the population and result in significant personal, social and economic costs. Understanding of the causes of, and consequently the most effective interventions for, this condition is an area requiring development. Drawing upon theories of Bipolar Disorder that propose the condition to be underpinned by dysregulation of systems governing behavioural activation or approach motivation, we present a mathematical model of the regulation of behavioural activation. The model is informed by non-linear, dynamical principles and as such proposes that the transition from "non-bipolar" to "bipolar" diagnostic status corresponds to a switch from mono- to multistability of behavioural activation level, rather than an increase in oscillation of mood. Consistent with descriptions of the behavioural activation or approach system in the literature, auto-activation and auto-inhibitory feedback is inherent within our model. Comparison between our model and empirical, observational data reveals that by increasing the non-linearity dimension in our model, important features of Bipolar Spectrum disorders are reproduced. Analysis from stochastic simulation of the system reveals the role of noise in behavioural activation regulation and indicates that an increase of nonlinearity promotes noise to jump scales from small fluctuations of activation levels to longer lasting, but less variable episodes. We conclude that further research is required to relate parameters of our model to key behavioural and biological variables observed in Bipolar Disorder.
authors.affiliation: Systems Biology Group, College of Engineering, Mathematics, and Physical Sciences, University of Exeter, Exeter, United Kingdom. A.Steinacher@exeter.ac.uk
authors.forename: Arno
authors.initials: A
authors.lastname: Steinacher
authors.forename: Kim A
authors.initials: KA
authors.lastname: Wright
mesh_terms: D001519:Behavior; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000503:physiopathology*; D025461:Feedback, Physiological; D008954:Models, Biological; D017711:Nonlinear Dynamics; D013269:Stochastic Processes; D013997:Time Factors