title: Robustness of TCA cycle at steady-state: an LMI-based analysis and synthesis framework.
abstract: A novel analysis and synthesis framework is devised for synergism and saturation system, commonly known as S-system, for improving the robustness of the TCA cycle. In order to minimize the perturbation sensitivity, a measure of robustness of the network, a new design framework is proposed. The design constraints are formulated in computationally attractive convex optimization framework. The proposed multi-objective optimization problem, framed as Linear Matrix Inequality (LMI), makes a trade-off between the robustness and the control effort of the synthesized TCA cycle.
authors.affiliation: Department of Electrical Engineering, Indian Institute of Technology, 721302 Kharagpur, WB, India.
authors.forename: Surajit
authors.initials: S
authors.lastname: Panja
authors.forename: Sourav
authors.initials: S
authors.lastname: Patra
authors.forename: Anirban
authors.initials: A
authors.lastname: Mukherjee
authors.forename: Madhumita
authors.initials: M
authors.lastname: Basu
authors.forename: Sanghamitra
authors.initials: S
authors.lastname: Sengupta
authors.forename: Pranab K
authors.initials: PK
authors.lastname: Dutta
mesh_terms: D002952:Citric Acid Cycle; D003198:Computer Simulation; D004023:Dictyostelium / Q000378:metabolism*; D008954:Models, Biological; D049490:Systems Biology