title: [Senile systemic amyloidosis: definition, diagnosis, why thinking about?].
abstract: Senile systemic amyloidosis (SSA) is characterized by infiltration of amyloid transthyretin fibrils in the myocardium. SSA occurs mainly (but not always) in elderly men. SSA leads to hypertrophic and/or restrictive cardiomyopathy complicated by conduction disturbances, atrial arrhythmia and systemic embolization (stroke…). That is why SSA needs a special care and to be diagnosed. Cardiac SSA diagnosis needs to exclude two other forms of cardiac amyloidosis: AL amyloidosis (light chain) and hereditary transthyretin amyloidosis (genetic testing). Scintigraphic 99mTc-DPD heart retention is observed in cardiac amyloidosis. DPD heart retention is more frequent in cardiac transthyretin amyloidosis than in cardiac AL amyloidosis. Specific treatments of cardiac TTR amyloidosis are in development.
authors.affiliation: CHU Henri-Mondor, fédération de cardiologie, 94000 Créteil, France. thibaud.damy@hmn.aphp.fr
authors.forename: Thibaud
authors.initials: T
authors.lastname: Damy
authors.forename: Dania
authors.initials: D
authors.lastname: Mohty
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Deux
authors.forename: Jean
authors.initials: J
authors.lastname: Rosso
authors.forename: Nicole
authors.initials: N
authors.lastname: Benhaiem
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lellouche
authors.forename: Laurent
authors.initials: L
authors.lastname: Sabbah
authors.forename: Soulef
authors.initials: S
authors.lastname: Guendouz
authors.forename: Claire-Marie
authors.initials: CM
authors.lastname: Tissot
authors.forename: Stéphane
authors.initials: S
authors.lastname: Rappeneau
authors.forename: Dionyssis
authors.initials: D
authors.lastname: Pongas
authors.forename: Diane
authors.initials: D
authors.lastname: Bodez
authors.forename: Sébastien
authors.initials: S
authors.lastname: Krypciak
authors.forename: Aziz
authors.initials: A
authors.lastname: Guellich
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Dubois-Randé
authors.forename: Luc
authors.initials: L
authors.lastname: Hittinger
authors.forename: Jean-Pascal
authors.initials: JP
authors.lastname: Lefaucheur
authors.forename: Arnaud
authors.initials: A
authors.lastname: Jaccard
authors.forename: Violaine
authors.initials: V
authors.lastname: Planté-Bordeneuve
mesh_terms: D000367:Age Factors; D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis* / Q000628:therapy; D003663:Decision Trees; D006331:Heart Diseases / Q000175:diagnosis* / Q000628:therapy; D006801:Humans