title: Mitochondrial haplogroups are associated with clinical pattern of AIDS progression in HIV-infected patients.
abstract: We performed a cross-sectional study in 469 HIV-infected patients, whose mitochondrial haplogroups were genotyped to study their association with the clinical pattern of AIDS progression. The chance of not having an AIDS progression was 1.45 [95% of confidence interval (CI) = 1.02 to 2.05, P = 0.035) times greater in patients with cluster HV and 1.51 (95% CI = 1.06 to 2.18, P = 0.021) times greater in patients with haplogroup H. However, we only found significant values for haplogroup H (odds ratio = 1.52, 95% CI = 1.01 to 2.32, P = 0.049) in an ordinal logistic regression adjusted by gender, age at HIV infection, intravenous drug users, and hepatitis C virus infection. These data suggest that mitochondrial haplogroups might play a significant role in AIDS progression.
authors.affiliation: Unidad de Coinfección HIV/Hepatitis, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Guzmán-Fulgencio
authors.forename: José Luis
authors.initials: JL
authors.lastname: Jiménez
authors.forename: Mónica
authors.initials: M
authors.lastname: García-Álvarez
authors.forename: José María
authors.initials: JM
authors.lastname: Bellón
authors.forename: Amanda
authors.initials: A
authors.lastname: Fernández-Rodriguez
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Campos
authors.forename: Carmen
authors.initials: C
authors.lastname: Rodríguez
authors.forename: Juan
authors.initials: J
authors.lastname: González-Garcia
authors.forename: Melchor
authors.initials: M
authors.lastname: Riera
authors.forename: Pompeyo
authors.initials: P
authors.lastname: Viciana
authors.forename: Ma Ángeles
authors.initials: MÁ
authors.lastname: Muñoz-Fernández
authors.forename: Salvador
authors.initials: S
authors.lastname: Resino
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D004272:DNA, Mitochondrial / Q000032:analysis / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species