title: Analysis of plasma multiplex cytokines for children with febrile seizures and severe acute encephalitis.
abstract: We investigated the plasma cytokine profiles of children with febrile seizures or severe acute encephalitis using multiplex cytometry to evaluate the role of cytokines in these diseases. Interleukin-6, -10, -12p70, -17A, -2, -4, -5, -9, -13, -22, and -1β, interferon-γ, and tumor necrosis factor-α were measured in the plasma from children with febrile seizures (n = 9) or severe acute encephalitis (n = 21). In multivariate analysis, interleukin-6 was significantly increased in the plasma of the febrile seizure patients compared to those with severe acute encephalitis, suggesting that interleukin-6 is activated during the acute stage of a febrile seizure. A lower plasma interleukin-6 concentration was significantly associated with severe acute encephalitis. The cytokine network may be deregulated in severe acute encephalitis via the persistence of an uncontrolled inflammatory state in the brain.
authors.affiliation: 1Department of Pediatrics, Chang Gung Memorial Hospital, Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Hu
authors.forename: Go-Shine
authors.initials: GS
authors.lastname: Huang
authors.forename: Chang-Teng
authors.initials: CT
authors.lastname: Wu
authors.forename: Jainn-Jim
authors.initials: JJ
authors.lastname: Lin
authors.forename: Shao-Hsuan
authors.initials: SH
authors.lastname: Hsia
authors.forename: Huei-Shyong
authors.initials: HS
authors.lastname: Wang
authors.forename: Kuang-Lin
authors.initials: KL
authors.lastname: Lin
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D004660:Encephalitis / Q000097:blood*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D007378:Interleukins / Q000097:blood*; D008297:Male; D015999:Multivariate Analysis; D003294:Seizures, Febrile / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015850:Interleukin-6; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma
keywords: cytokine; febrile seizures; inflammation; interleukin-6; severe acute encephalitis