title: A novel polymorphism of the CYP2J2 gene is associated with coronary artery disease in Uygur population in China.
abstract: BACKGROUND
  Cytochrome P450 (CYP) 2J2 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs). The EETs are potent endogenous vasodilators and inhibitors of vascular inflammation. The aim of the present study was to assess the association between the human CYP2J2 gene polymorphism and coronary artery disease (CAD) in a Han and Uygur population of China.
  
  
  METHODS
  We use two independent case-control studies: a Han population (206 CAD patients and 262 control subjects) and an Uygur population (336 CAD patients and 448 control subjects). All CAD patients and controls were genotyped for the same three single nucleotide polymorphisms (SNPs) (rs890293, rs11572223 and rs2280275) of CYP2J2 gene by a real-time PCR instrument.
  
  
  RESULTS
  In the Uygur population, for total, the distribution of SNP3 (rs2280275) genotypes showed a significant difference between CAD and control participants (P=0.048). For total and men, the distribution of SNP3 (rs2280275) alleles and the dominant model (CC vs CT+TT) showed a significant difference between CAD and control participants (for allele: P=0.014 and P=0.035, respectively; for dominant model: P=0.014 and P=0.034, respectively). The significant difference in dominant model was retained after adjustment for covariates (OR: 0.279, 95% confidence interval [CI]: 0.176-0.440, P=0.001; OR: 0.240, 95% CI: 0.128-0.457, P=0.001, respectively).
  
  
  CONCLUSIONS
  The CC genotype of rs2280275 in CYP2J2 gene could be a protective genetic marker of CAD and T allele may be a risk genetic marker of CAD in men of Uygur population in China.
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Zhenyan
authors.initials: Z
authors.lastname: Fu
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. Electronic address: myt-xj@163.com.
authors.forename: Yitong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Ding
authors.initials: D
authors.lastname: Huang
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Erdenbat
authors.initials: E
authors.lastname: Cha
mesh_terms: D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics*; D000090762:Cytochrome P-450 CYP2J2; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007438:Introns / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C000717350:CYP2J2 protein, human; D003577:Cytochrome P-450 Enzyme System; D000090762:Cytochrome P-450 CYP2J2
keywords: CYP2J2; Case–control study; Coronary artery disease; Single nucleotide polymorphism