title: Predicting early death after cardiovascular surgery by using the Texas Heart Institute Risk Scoring Technique (THIRST).
abstract: Preoperative risk-prediction models are an important tool in contemporary surgical practice. We developed a risk-scoring technique for predicting in-hospital death for cardiovascular surgery patients. From our institutional database, we obtained data on 21,120 patients admitted from 1995 through 2007. The outcome of interest was early death (in-hospital or within 30 days of surgery). To identify mortality predictors, multivariate logistic regression was performed on data from 14,030 patients from 1995 through 2002 and risk scores were computed to stratify patients (low-, medium-, and high-risk). A recalibrated model was then created from the original risk scores and validated on data from 7,090 patients from 2003 through 2007. Significant predictors of death included urgent surgery within 48 hours of admission, advanced age, renal insufficiency, repeat coronary artery bypass grafting, repeat aortic aneurysm repair, concomitant aortic aneurysm or left ventricular aneurysm repair with coronary bypass or valvular surgery, and preoperative intra-aortic balloon pump support. Because the original model overpredicted death for operations performed from 2003 through 2007, this was adjusted for by applying the recalibrated model. Applying the recalibrated model to the validation set revealed predicted mortality rates of 1.7%, 4.2%, and 13.4% and observed rates of 1.1%, 5.1%, and 13%, respectively. Because our model discriminates risk groups by using preoperative clinical criteria alone, it can be a useful bedside tool for identifying patients at greater risk of early death after cardiovascular surgery, thereby facilitating clinical decision-making. The model can be recalibrated for use in other types of patient populations.
authors.affiliation: Division of Cardiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Sanon
authors.forename: Vei-Vei
authors.initials: VV
authors.lastname: Lee
authors.forename: MacArthur A
authors.initials: MA
authors.lastname: Elayda
authors.forename: Sreedevi
authors.initials: S
authors.lastname: Gondi
authors.forename: James J
authors.initials: JJ
authors.lastname: Livesay
authors.forename: George J
authors.initials: GJ
authors.lastname: Reul
authors.forename: James M
authors.initials: JM
authors.lastname: Wilson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000401:mortality*; D003661:Decision Support Techniques; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012372:ROC Curve; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects / Q000401:mortality*
keywords: Cardiac surgical procedures/mortality; ROC curve; United States/epidemiology; evaluation studies as topic; hospital mortality; logistic models; models, statistical; outcome assessment (health care)/methods; predictive value of tests; regression analysis of tests; risk assessment/classification/methods/statistics & numerical data; risk factors; statistics as topic