title: [Neuro-autonomic inhibition and haemodynamics management optimization during cesarean section under spinal anaesthesia in pregnant women with gestosis].
abstract: Results showed that autonomic nervous system (ANS) and blood circulation system (BCS) dysfunction in 3rd trimester pregnant women with gestosis are more pronounced, than in healthy pregnant women, despite the prescribed treatment. The most significant disturbances were vagotonia and hypokinetic haemodynamics type (often iatrogenic). Spinal anaesthesia (SA) during Cesarean section in pregnant women is accompanied by blood pressure decrease to the level demanding on vasopressors use. Considering normal indicators of SI, CI, oxygen transportation and electrocardiogram vasopressor was not introduced Apgar score assessment of newborns was within normal. However, vagotonia and hypokinetic haemodynamics type during anaesthesia that certifies autoregulation reserves insufficiency. Atropine introduction in pregnant women with vagotonia and hypokinetic haemodynamics type (often iatrogenic, owing to irrational therapy) before SA beginning of promoted neurovegetative inhibition optimization and haemodynamics stabilization in eukinetic range. Vagus blockade (elimination of ANS dysfunction) was accompanied by more physiologic sympathicotonia development with smaller decrease of blood pressure (without stroke index reduction!), absence of bradycardia and vomiting. Research showed that the blood pressure cannot be the only objective criterion of vasopressors use.
authors.forename: V A
authors.initials: VA
authors.lastname: Gur'ianov
authors.forename: I V
authors.initials: IV
authors.lastname: Shumov
mesh_terms: D000773:Anesthesia, Obstetrical / Q000009:adverse effects* / Q000379:methods; D000775:Anesthesia, Spinal / Q000009:adverse effects* / Q000379:methods; D001034:Apgar Score; D001285:Atropine / Q000008:administration & dosage / Q000627:therapeutic use*; D001341:Autonomic Nervous System / Q000187:drug effects*; D002585:Cesarean Section / Q000379:methods*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007022:Hypotension / Q000517:prevention & control; D007231:Infant, Newborn; D010276:Parasympatholytics / Q000008:administration & dosage / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000503:physiopathology* / Q000601:surgery; D011247:Pregnancy; D011256:Pregnancy Outcome; D013346:Subarachnoid Space
chemical_list: D010276:Parasympatholytics; D001285:Atropine