title: Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.
abstract: The past decade has witnessed huge advances in our understanding of the genetics underlying Parkinson's disease. Identifying commonalities in the biological function of genes linked to Parkinson's provides an opportunity to elucidate pathways that lead to neuronal degeneration and eventually to disease. We propose that the genetic forms of Parkinson's disease largely associated with α-synuclein-positive neuropathology (SNCA, LRRK2, and GBA) are brought together by involvement in the autophagy/lysosomal pathway and that this represents a unifying pathway to disease in these cases.
authors.affiliation: Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK. c.manzoni@ucl.ac.uk
authors.forename: Claudia
authors.initials: C
authors.lastname: Manzoni
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Lewis
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D008954:Models, Biological; D009410:Nerve Degeneration / Q000235:genetics / Q000378:metabolism*; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism*; D051844:alpha-Synuclein / Q000235:genetics / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein
keywords: GBA; LRRK2; Parkinson's disease