title: Bilateral common carotid artery occlusion as an adequate preconditioning stimulus to induce early ischemic tolerance to focal cerebral ischemia.
abstract: There is accumulating evidence, that ischemic preconditioning - a non-damaging ischemic challenge to the brain - confers a transient protection to a subsequent damaging ischemic insult. We have established bilateral common carotid artery occlusion as a preconditioning stimulus to induce early ischemic tolerance to transient focal cerebral ischemia in C57Bl6/J mice. In this video, we will demonstrate the methodology used for this study.
authors.affiliation: Department of Neurology, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Germany.
authors.forename: Lukas Julius
authors.initials: LJ
authors.lastname: Speetzen
authors.forename: Matthias
authors.initials: M
authors.lastname: Endres
authors.forename: Alexander
authors.initials: A
authors.lastname: Kunz
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases; D001921:Brain / Q000098:blood supply*; D017536:Carotid Artery, Common / Q000601:surgery; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery; D002546:Ischemic Attack, Transient; D019194:Ischemic Preconditioning / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL