title: Stable acid-responsive electrospun biodegradable fibers as drug carriers and cell scaffolds.
abstract: Acid-responsive electrospun fibers are fabricated by introducing sodium bicarbonate into PLLA fibers using an emulsion method. This novel electrospun fibrous scaffold exhibits a rapid acid-responsive controlled drug release (early stage) and stable three-dimensional (3D) structure as a tissue engineering scaffold (late stage) for cell growth.
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Zhao
authors.forename: Shen
authors.initials: S
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Huilin
authors.initials: H
authors.lastname: Yang
authors.forename: Cunyi
authors.initials: C
authors.lastname: Fan
authors.forename: Wenguo
authors.initials: W
authors.lastname: Cui
mesh_terms: D001672:Biocompatible Materials; D049109:Cell Proliferation / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D019344:Lactic Acid / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use*; D017693:Sodium Bicarbonate / Q000737:chemistry; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D011108:Polymers; D019344:Lactic Acid; D017693:Sodium Bicarbonate
keywords: acid-responsive; drug delivery systems; electrospun; fibrous scaffolds; tissue engineering