title: Acute haemolytic reaction due to anti-Wb: a case report.
abstract: A 73-year-old Greek woman presented with symptomatic anaemia requiring red cell transfusion in the setting of progressive chronic lymphocytic leukaemia (CLL). Based on a negative antibody screen, two units of red blood cells (RBCs) were provided for transfusion. During the transfusion, the patient developed an acute haemolytic transfusion reaction (HTR), but recovered with supportive measures. Subsequent antibody investigation confirmed that the patient had an anti-Wb antibody and that the implicated RBC unit was Wb-positive. This is the first report of an anti-Wb causing a clinically significant acute HTR in the literature.
authors.affiliation: Austin Pathology, Austin Health, Heidelberg, Victoria, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Wright
authors.forename: P
authors.initials: P
authors.lastname: Brown
authors.forename: I
authors.initials: I
authors.lastname: Marais
authors.forename: F S
authors.initials: FS
authors.lastname: Hong
mesh_terms: D000368:Aged; D000740:Anemia / Q000628:therapy; D001789:Blood Group Antigens / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000175:diagnosis / Q000276:immunology*; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D005260:Female; D006461:Hemolysis / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000097:blood* / Q000276:immunology
chemical_list: D001789:Blood Group Antigens; D007518:Isoantibodies
keywords: Gerbich antigens; Wb antigen; acute haemolytic transfusion reaction; anti-Wb