title: Antifouling indole alkaloids from two marine derived fungi.
abstract: In order to find non-toxic antifouling natural products from marine microorganisms, the chemical constituents of two marine derived fungi Penicillium sp. and Aspergillus sydowii have been investigated under bio-guided fractionation. A new indolyl diketopiperazine compound, penilloid A (1), together with 15 known ones were isolated from these two strains. The structure of 1 was elucidated on the basis of NMR and mass spectra. Some alkaloids showed significant antifouling and antibacterial activities. The results indicate that indole alkaloids could be a potential antifouling agent resource.
authors.affiliation: Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, The Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, Guangdong, China.
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Han
authors.forename: Jiang
authors.initials: J
authors.lastname: Peng
authors.forename: Pei-Yuan
authors.initials: PY
authors.lastname: Qian
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Qi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D026121:Indole Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010407:Penicillium / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D026121:Indole Alkaloids