title: [Inhibition of RANK-L in the pathophysiology of osteoporosis. Clinical evidences of its use].
abstract: The increase bone turnover is the most important fact at the physiopathology of postmenopausal osteoporosis. At the molecular level it is the increase of the RANK-L the principal mediator who allows the osteoclasts formation, survival and development of them. Multiple models have been in use in preclinical investigations for evaluating the effects of the inhibition of the RANKL, between which it is included on OPG's over-expression in mice and transgenic mouse and by means of other models that include the treatment with recombinant OPG. The results of these studies show that RANKL's inhibition improves the DMO as well as the geometry and resistance of the bone. Several references clinical trials have investigated the potential of denosumab as antiresorptive drug for the prevention and treatment of bone disease. It is a monoclonal antibody, the first fully human, which were recently published results of randomized clinical trials to eight years for increasing BMD in different locations and five years for the prevention of vertebral and hip fractures. We review the fundamentals of the mechanism of inhibition of RANK-L and the results of several clinical trials of Denosumab.
authors.affiliation: Servicio de Ginecología y Obstetricia, Facultad de Medicina y Odontología, Grupo de trabajo de Osteoporosis de la Associación Española para el Estudio de la Menopausia, Universidad del País Vasco, EUH-UPV. jlneyro@sego.es
authors.forename: José
authors.initials: J
authors.lastname: Luis Neyro
authors.forename: María
authors.initials: M
authors.lastname: Jesús Cancelo
authors.forename: Santiago
authors.initials: S
authors.lastname: Palacios
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000069448:Denosumab; D005260:Female; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D053245:RANK Ligand / Q000037:antagonists & inhibitors / Q000502:physiology*; D016032:Randomized Controlled Trials as Topic
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D053245:RANK Ligand; D000069448:Denosumab