title: [Perinatal infection by rubella virus in breast-fed babies with congenital heart disease].
abstract: BACKGROUND
  seroepidemiological surveys suggest that approximately 20 % of women of childbearing age are susceptible to rubella. It is necessary to detect congenital rubella cases. Our objective was to determine the frequency of perinatal infection by rubella virus (RV) in infants with congenital heart disease.
  
  
  METHODS
  prospective, cross-sectional study. We studied hospitalized and outpatients from September 2007 to December 2008. Neonates and infants under one year of age with congenital heart disease were included. A blood sample of 3 mL was taken from mother-child binomial and micro-ELISA for IgG and IgM against rubella were performed.
  
  
  RESULTS
  80 patients were studied, 56 % were female, with a median age of 3 months. More frequent congenital heart disease was ventricular septal defect (28.5 %), followed by atrial septal defect (17.5 %). Median maternal age was 28 years old. A history of febrile illness and rash during pregnancy was positive in 1.25 %. 7 cases of perinatal infection by RV were detected, three met the criteria for congenital rubella syndrome, and four had only congenital heart disease.
  
  
  CONCLUSIONS
  the search for cases of congenital rubella syndrome in newborns and infants with heart disease could be used as a strategy to detect non-obvious cases.
authors.affiliation: Dirección Médica, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, México. fortino.solorzano@imss.gob.mx.
authors.forename: Fortino
authors.initials: F
authors.lastname: Solórzano-Santos
authors.forename: Selene Jeannette
authors.initials: SJ
authors.lastname: Bárcenas-López
authors.forename: Gloria C
authors.initials: GC
authors.lastname: Huerta-García
authors.forename: María Guadalupe
authors.initials: MG
authors.lastname: Miranda-Novales
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Alvarez-Y Muñoz
authors.forename: José Guillermo
authors.initials: JG
authors.lastname: Vázquez-Rosales
mesh_terms: D000293:Adolescent; D000328:Adult; D001942:Breast Feeding; D003430:Cross-Sectional Studies; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications / Q000453:epidemiology*; D006331:Heart Diseases / Q000150:complications / Q000151:congenital* / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D012409:Rubella / Q000150:complications / Q000453:epidemiology*; D012410:Rubella Syndrome, Congenital / Q000150:complications / Q000453:epidemiology; D055815:Young Adult
keywords: congenital heart defect; congential rubella syndrome; infant