title: The role of vitamin C in prevention of preterm premature rupture of membranes.
abstract: BACKGROUND
  Preterm premature rupture of membranes (PPROM) is one of the most important complications of the pregnancy and cause perinatal morbidity and mortality. History of PPROM is a risk factor of recurrent PPROM. Vitamin C plays an important role in collagen metabolism and increases resistance maintenance of the chorioamniotic membranes.
  
  
  OBJECTIVE
  The aim of this study is to evaluate the role of vitamin C supplementation in prevention of PPROM in women with a positive history of PPROM.
  
  
  METHODS
  This clinical trial study was performed on 170 pregnant women with the history of PPROM, with singleton pregnancy and gestational age 14 weeks in Imam-Reza Hospital, Mashhad University of Medical Sciences during 2008 to 2010. They were randomly divided into two groups. The case patients received 100 mg vitamin C daily from 14th weeks of gestation. PPROM occurrence was compared between two groups as an indicator of the protective effect of vitamin C supplements.
  
  
  RESULTS
  PPROM occurred in 44.7% of controls and 31.8% of cases (P &lt; 0.05). PROM occurred in 34.1% of controls and 18.8% of cases (P &lt; 0.05). Pregnancy was terminated at term gestation in 21.2% of controls and 49.4% of cases (P &lt; 0.05). Rupture of membranes was significantly decreased in the case group.
  
  
  CONCLUSIONS
  Vitamin C supplementations after 14th weeks of gestation can prevent from PPROM in women with the history of PPROM.
authors.affiliation: Department of Obstetrics and Gynecology, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
authors.forename: Nayereh
authors.initials: N
authors.lastname: Ghomian
authors.forename: Leili
authors.initials: L
authors.lastname: Hafizi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Takhti
keywords: Ascorbic Acid; Fetal Membranes, Premature Rupture; Pregnancy; Prevention and Control