title: Extracorporeal membrane oxygenation: beneficial strategy for lung transplant recipients.
abstract: The role of extracorporeal membrane oxygenation (ECMO) as a therapeutic strategy has been very well documented for over a decade now with consistently positive remarks. The aim of the present study was analyzing the outcome of ECMO application in our lung transplant program, especially the feasibility and safety of our ECMO approach. Therefore, we retrospectively analyzed the data of 15 patients recipients requiring ECMO support. We analyzed clinical data, complications, and survival of the lung-transplanted population that needed ECMO support at our institution from 2006-2009. During that period, 19 applications of ECMO were done on 15 adult patients with the following indications: primary graft dysfunction (10 patients), "bridge to transplantation" (five), pulmonary hypertension (three), and severe acute respiratory distress syndrome (one). At 28 days, the overall survival was 93% (14 of 15 patients) and 12 of these patients (80%) survived at least 6 months. Complications included acute renal insufficiency with temporary need of renal replacement therapy (53%), bleeding (33%), critical illness polyneuropathy (66%), and reversible thrombocytopenia (73%). Based on the evaluation of the patients in this analysis, ECMO seems to be a safe therapeutic approach in lung transplant recipients with severe respiratory failure directly after transplantation.
authors.affiliation: Surgical Intensive Care Medicine, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Silvia R
authors.initials: SR
authors.lastname: Cottini
authors.forename: Urs
authors.initials: U
authors.lastname: Wenger
authors.forename: Susanne
authors.initials: S
authors.lastname: Sailer
authors.forename: Paul A
authors.initials: PA
authors.lastname: Stehberger
authors.forename: Reto A
authors.initials: RA
authors.lastname: Schuepbach
authors.forename: Peter
authors.initials: P
authors.lastname: Hasenclever
authors.forename: Markus
authors.initials: M
authors.lastname: Wilhelm
authors.forename: Markus
authors.initials: M
authors.lastname: Béchir
mesh_terms: D000293:Adolescent; D000328:Adult; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary; D053208:Kaplan-Meier Estimate; D016040:Lung Transplantation / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D055031:Primary Graft Dysfunction / Q000453:epidemiology; D012128:Respiratory Distress Syndrome; D012189:Retrospective Studies; D016896:Treatment Outcome