title: Family-based genome-wide copy number scan identifies five new genes of dyslexia involved in dendritic spinal plasticity.
abstract: Genome-wide screening for copy number variations (CNVs) in ten Indian dyslexic families revealed the presence of five de novo CNVs in regions harboring GABARAP, NEGR1, ACCN1, DCDC5, and one in already known candidate gene CNTNAP2. These genes are located on regions of chromosomes 17p13.1, 1p31.1, 17q11.21, 11p14.1 and 7q35, respectively, and are implicated in learning, cognition and memory processes through dendritic spinal plasticity, though not formally associated with dyslexia. Molecular network analysis of these and other dyslexia-related module genes suggests them to be associated with synaptic transmission, axon guidance and cell adhesion. Thus, we suggest that dyslexia may also be caused by neuronal disconnection in addition to the earlier view that it is due to neuronal migrational disorder.
authors.affiliation: Genomics Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore, India.
authors.forename: Avinash M
authors.initials: AM
authors.lastname: Veerappa
authors.forename: Marita
authors.initials: M
authors.lastname: Saldanha
authors.forename: Prakash
authors.initials: P
authors.lastname: Padakannaya
authors.forename: Nallur B
authors.initials: NB
authors.lastname: Ramachandra
mesh_terms: D000293:Adolescent; D002648:Child; D019457:Chromosome Breakage; D056915:DNA Copy Number Variations / Q000235:genetics*; D049229:Dendritic Spines / Q000378:metabolism*; D004410:Dyslexia / Q000235:genetics*; D005190:Family; D005260:Female; D063990:Gene Ontology; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D009473:Neuronal Plasticity / Q000235:genetics*; D009483:Neuropsychological Tests; D010641:Phenotype; D011110:Polymorphism, Genetic; D060066:Protein Interaction Maps / Q000235:genetics; D015203:Reproducibility of Results; D015398:Signal Transduction / Q000235:genetics; D055815:Young Adult