title: Isolated paediatric neurosarcoidosis presenting as epilepsia partialis continua: a case report and review of literature.
abstract: Isolated paediatric neurosarcoidosis (IPN) is exceptionally rare and only seven cases have been reported so far in the literature. We report the clinical and radiological profile of a 7 year-old boy with epilepsia partialis continua (EPC) who was initially thought to have Acute Disseminated Encephalomyelitis (ADEM), but was subsequently found to have isolated neurosarcoidosis. Additionally, we performed a literature search on Medline and Embase and secondary sources of data such as reference list of articles reviewed. Whilst cranial neuropathy is the commonest presenting feature in adults with neurosarcoidosis, paediatric patients are more likely to present with seizures. Diagnosis presents a clinical challenge as a result of its protean manifestations. Due to its rarity, there remains a lack of evidence base to inform the best choice of treatment for these children. Our patient was successfully treated with a combination of various immunomodulants.
authors.affiliation: Department of Paediatric Neurology, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. anandgeetha97@gmail.com
authors.forename: Geetha
authors.initials: G
authors.lastname: Anand
authors.forename: Fang En
authors.initials: FE
authors.lastname: Sin
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Soilleux
authors.forename: Julie
authors.initials: J
authors.lastname: Chandra
authors.forename: Katharine
authors.initials: K
authors.lastname: Piddington
authors.forename: Gerardine
authors.initials: G
authors.lastname: Quaghebeur
authors.forename: Nick
authors.initials: N
authors.lastname: Wilkinson
authors.forename: Zenobia
authors.initials: Z
authors.lastname: Zaiwalla
authors.forename: Robin
authors.initials: R
authors.lastname: Kennett
authors.forename: Tony
authors.initials: T
authors.lastname: McShane
mesh_terms: D002493:Central Nervous System Diseases / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D002648:Child; D003937:Diagnosis, Differential; D004673:Encephalomyelitis, Acute Disseminated / Q000150:complications / Q000175:diagnosis*; D017036:Epilepsia Partialis Continua / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D056747:Immunomodulation / Q000276:immunology; D008297:Male; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D012640:Seizures / Q000150:complications / Q000175:diagnosis*; D016896:Treatment Outcome
keywords: Child; Epilepsia partialis continua; Neurosarcoidosis