title: Young little mice express a premature cardiovascular aging phenotype.
abstract: To investigate the effect of growth hormone and insulin-like growth factor 1 deficiency on the aging mouse arterial system, we compared the hemodynamics in young (4 months) and old (30 months) growth hormone-releasing hormone receptor null dwarf (Little) mice and their wild-type littermates. Young Little mice had significantly lower peak and mean aortic velocity and significantly higher aortic impedance than young wild-type mice. However, unlike the wild-type mice, there were no significant changes in arterial function with age in the Little mice. Aortic pulse wave velocity estimated using characteristic impedance increased with age in the wild-type mice, but it changed minimally in the Little mouse. We therefore conclude that arterial function in Little mice expresses a premature aging phenotype at young age and may neither enhance nor reduce their longevity.
authors.affiliation: Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, MS BCM620, Houston, TX 77030. areddy@bcm.edu.
authors.forename: Anilkumar K
authors.initials: AK
authors.lastname: Reddy
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Hartley
authors.forename: Thuy T
authors.initials: TT
authors.lastname: Pham
authors.forename: Gretchen
authors.initials: G
authors.lastname: Darlington
authors.forename: Mark L
authors.initials: ML
authors.lastname: Entman
authors.forename: George E
authors.initials: GE
authors.lastname: Taffet
mesh_terms: D000375:Aging / Q000502:physiology*; D019588:Aging, Premature / Q000209:etiology*; D000818:Animals; D001011:Aorta / Q000254:growth & development* / Q000503:physiopathology*; D062186:Arterial Pressure / Q000502:physiology; D001783:Blood Flow Velocity / Q000502:physiology; D013006:Growth Hormone / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains; D010641:Phenotype
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
keywords: Aortic impedance; Cardiovascular function; GH/IGF-1 deficiency; Longevity.; Pulse wave velocity