title: Endocervical glandular involvement, multicentricity, and extent of the disease are features of high-grade cervical intraepithelial neoplasia.
abstract: This study aimed to evaluate the rate of endocervical glandular involvement, positive surgical margins, multicentricity, and disease extent between low-grade and high-grade cervical intraepithelial lesions after loop electrosurgical excision procedure (LEEP). Pathology medical records of patients who underwent LEEP were reviewed retrospectively. Patients with negative LEEP results were excluded. Loop electrosurgical excision procedure reports of patients with cervical intraepithelial neoplasia (CIN) 1, 2, and 3 were compared. There was no statistically significant difference between patients with CIN 1 (n=24), CIN 2 (n=27), and CIN 3 (n=64) when age and surgical margin positivity were considered. Endocervical glandular involvement, multicentricity, and disease extent were higher in patients with CIN 3 (P=.001, P=.002, and P=.001, respectively). In conclusion, we recommend that patients with endocervical glandular involvement, lesions involving more than two-thirds of the LEEP specimen, and multicentricity be followed up more closely.
authors.affiliation: Department of Obstetrics and Gynecology, İstanbul Bilim University, Istanbul, Turkey. nilgun.kutay@gmail.com
authors.forename: Nilgün
authors.initials: N
authors.lastname: Güdücü
authors.forename: Güliz
authors.initials: G
authors.lastname: Sidar
authors.forename: Nuray
authors.initials: N
authors.lastname: Başsüllü
authors.forename: Ilknur
authors.initials: I
authors.lastname: Türkmen
authors.forename: Ilkkan
authors.initials: I
authors.lastname: Dünder
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000473:pathology* / Q000601:surgery; D004598:Electrosurgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D012307:Risk Factors; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery; D055815:Young Adult
keywords: Disease extent; Endocervical glandular involvement; LEEP; Multicentricity; Positive surgical margins