title: A network perspective on unraveling the role of TRP channels in biology and disease.
abstract: Transient receptor potential (TRP) channels are a large family of non-selective cation channels that mediate numerous physiological and pathophysiological processes; however, still largely unknown are the underlying molecular mechanisms. With data generated on an unprecedented scale, network-based approaches have been revolutionizing the way in which we understand biology and disease, discover disease genes, and develop therapeutic strategies. These circumstances have created opportunities to encounter TRP channel research to data-intensive science. In this review, we provide an introduction of network-based approaches in biomedical science, describe the current state of TRP channel network biology, and discuss the future direction of TRP channel research. Network perspective will facilitate the discovery of latent roles and underlying mechanisms of TRP channels in biology and disease.
authors.affiliation: Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, South Korea.
authors.forename: Jung Nyeo
authors.initials: JN
authors.lastname: Chun
authors.forename: Jin Muk
authors.initials: JM
authors.lastname: Lim
authors.forename: Young
authors.initials: Y
authors.lastname: Kang
authors.forename: Eung Hee
authors.initials: EH
authors.lastname: Kim
authors.forename: Young-Cheul
authors.initials: YC
authors.lastname: Shin
authors.forename: Hong-Gee
authors.initials: HG
authors.lastname: Kim
authors.forename: Dayk
authors.initials: D
authors.lastname: Jang
authors.forename: Dongseop
authors.initials: D
authors.lastname: Kwon
authors.forename: Soo-Yong
authors.initials: SY
authors.lastname: Shin
authors.forename: Insuk
authors.initials: I
authors.lastname: So
authors.forename: Ju-Hong
authors.initials: JH
authors.lastname: Jeon
mesh_terms: D030562:Databases, Protein; D006801:Humans; D060066:Protein Interaction Maps; D055503:Protein Multimerization; D050051:Transient Receptor Potential Channels / Q000502:physiology*
chemical_list: D050051:Transient Receptor Potential Channels