title: A new biphenyl and other constituents from the wood of Garcinia schomburgkiana.
abstract: A new biphenyl, named schomburgbiphenyl (1), and 14 known compounds were isolated from the wood of Garcinia schomburgkiana. The known constituents were identified as follows: three xanthones (2, 8 and 9), two benzophenones (3 and 4), three biphenyls (5-7), three biflavonoids (10-12) and three steroids. Compounds 3 and 4 were highly cytotoxic to SW620 cell line (100 times more than the positive control, doxorubicin) and were also strongly active against KATO-III, HepG2 and CHAGO cell lines. Compound 6 was specifically cytotoxic towards SW620 cells, whereas compound 8 displayed strong cytotoxicity against all five cell lines tested.
authors.affiliation: a Department of Pharmacognosy and Pharmaceutical Botany , Faculty of Pharmaceutical Sciences, Chulalongkorn University , Bangkok , 10330 , Thailand.
authors.forename: Chutichot
authors.initials: C
authors.lastname: Mungmee
authors.forename: Supotchana
authors.initials: S
authors.lastname: Sitthigool
authors.forename: Anumart
authors.initials: A
authors.lastname: Buakeaw
authors.forename: Rutt
authors.initials: R
authors.lastname: Suttisri
mesh_terms: D001577:Benzophenones / Q000737:chemistry / Q000494:pharmacology; D044946:Biflavonoids / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D029760:Garcinia / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology; D013256:Steroids / Q000737:chemistry / Q000494:pharmacology; D014934:Wood / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000494:pharmacology
chemical_list: D001577:Benzophenones; D044946:Biflavonoids; D001713:Biphenyl Compounds; D010936:Plant Extracts; D013256:Steroids; D044004:Xanthones; C010574:biphenyl