title: Tetroazolemycins A and B, two new oxazole-thiazole siderophores from deep-sea Streptomyces olivaceus FXJ8.012.
abstract: Two new oxazole/thiazole derivatives, named tetroazolemycins A (1) and B (2), have been isolated from the acetone extract of the mycelium of Streptomyces olivaceus FXJ8.012 derived from deep-sea water, together with three known compounds, spoxazomicins A-C (3-5), isolated from the fermentation supernatant. The planar structure and relative configuration of tetroazolemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques, and showed to be new pyochelin-type antibiotics. Both compounds showed metal ion-binding activity and their Zn²⁺ complexes exhibited weak activity against pathogenic bacteria Klebsiella pneumoniae.
authors.affiliation: State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. fussliu@126.com
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.forename: Fei
authors.initials: F
authors.lastname: Shang
authors.forename: Lijun
authors.initials: L
authors.lastname: Xi
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D009792:Oceans and Seas; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017262:Siderophores / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis; D013302:Streptomyces / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015032:Zinc / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D054659:Diketopiperazines; D010080:Oxazoles; D017262:Siderophores; D013844:Thiazoles; C585411:tetroazolemycin A; C585412:tetroazolemycin B; D015032:Zinc