title: KDOQI US commentary on the 2012 KDIGO clinical practice guideline for management of blood pressure in CKD.
abstract: In response to the 2012 KDIGO (Kidney Disease: Improving Global Outcomes) guideline for blood pressure management in patients with chronic kidney disease not on dialysis, the National Kidney Foundation organized a group of US experts in hypertension and transplant nephrology to review the recommendations and comment on their relevancy in the context of current US clinical practice and concerns. The overriding message was the dearth of clinical trial evidence to provide strong evidence-based recommendations. For patients with CKD with normal to mildly increased albuminuria, goal blood pressure has been relaxed to ≤140/90 mm Hg for both diabetic and nondiabetic patients. In contrast, KDIGO continues to recommend goal blood pressure ≤130/80 mm Hg for patients with chronic kidney disease with moderately or severely increased albuminuria and for all renal transplant recipients regardless of the presence of proteinuria, without supporting data. The expert panel thought the KDIGO recommendations were generally reasonable but lacking in sufficient evidence support and that additional studies are greatly needed.
authors.affiliation: Division of Nephrology and Hypertension, College of Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Taler
authors.forename: Rajiv
authors.initials: R
authors.lastname: Agarwal
authors.forename: George L
authors.initials: GL
authors.lastname: Bakris
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Flynn
authors.forename: Peter M
authors.initials: PM
authors.lastname: Nilsson
authors.forename: Mahboob
authors.initials: M
authors.lastname: Rahman
authors.forename: Paul W
authors.initials: PW
authors.lastname: Sanders
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Textor
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Weir
authors.forename: Raymond R
authors.initials: RR
authors.lastname: Townsend
mesh_terms: D035843:Biomedical Research; D001794:Blood Pressure; D003928:Diabetic Nephropathies / Q000150:complications / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000628:therapy*; D017410:Practice Guidelines as Topic; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000503:physiopathology
keywords: Kidney Disease: Improving Global Outcomes (KDIGO); blood pressure; guideline