title: Orbital myeloid sarcoma presenting as massive proptosis.
abstract: A 10-year-old boy presented with right proptosis for 8 months. The eyeball was grossly pushed down, with diffuse corneal haze and non-reactive pupil. Systemic examination was normal. Previous investigations in another centre included a computerized tomography scan, which showed a well-defined enhancing retro-bulbar mass, a non-contributory fine needle aspiration cytology and a biopsy showing fibrocollagenous tissue with moderate lympho-monocytic infiltrate suggestive of non-specific inflammation. PET-CT scan revealed the presence of enlarged fluoro-deoxyglucose-avid cervical and mesenteric lymph nodes. Biopsy of the retro-bulbar mass was repeated in our centre. It showed fibrocollagenous and skeletal muscle tissue infiltrated by lymphoid follicles, dispersely lying lymphocytes and plasma cells, and admixed large atypical cells with vesicular nuclei, prominent nucleoli and scanty cytoplasm, strongly positive for myeloperoxidase, CD43 and CD99 immunohistochemistry. Hemogram was normal. Bone marrow aspiration/biopsy and CSF showed no evidence of acute myeloid leukemia. The child received chemotherapy in another centre and is in complete remission 6 months after completion.
authors.affiliation: Pediatric Hematology Oncology & BMT Unit, Department of Pediatrics, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India.
authors.forename: Veronique
authors.initials: V
authors.lastname: Dinand
authors.forename: Satya Prakash
authors.initials: SP
authors.lastname: Yadav
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Grover
authors.forename: Sunita
authors.initials: S
authors.lastname: Bhalla
authors.forename: Anupam
authors.initials: A
authors.lastname: Sachdeva
mesh_terms: D000071443:12E7 Antigen; D015703:Antigens, CD / Q000378:metabolism; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002648:Child; D005094:Exophthalmos / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D051917:Leukosialin / Q000378:metabolism; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D064847:Multimodal Imaging; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D009195:Peroxidase / Q000378:metabolism; D049268:Positron-Emission Tomography; D023981:Sarcoma, Myeloid / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; D000970:Antineoplastic Agents; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D051917:Leukosialin; D009195:Peroxidase