title: Energy landscapes of ligand-receptor couples probed by dynamic force spectroscopy.
abstract: Playing a dominant role in many biochemical processes are the dynamic properties of molecular linkages; examples include cell adhesion, enzyme-catalyzed reactions, and molecular recognition by antibodies. Dynamic force spectroscopy, namely separating molecular bonds under external force ramps has rapidly become a powerful tool to study the rugged energy landscape of noncovalent ligand-receptor bonds. The picture shows a surface and tip-bound pair being pulled apart and the derived potential energy diagram.
authors.affiliation: Institut für Physikalische Chemie, Johannes-Gutenberg Universität, 55128 Mainz, Germany. janshof@nwz.uni-muenster.de
authors.forename: A
authors.initials: A
authors.lastname: Janshoff
authors.forename: C
authors.initials: C
authors.lastname: Steinem
mesh_terms: D007700:Kinetics; D008024:Ligands; D018625:Microscopy, Atomic Force; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry*
chemical_list: D008024:Ligands; D011506:Proteins