title: Inhibition of proliferation of cervical and leukemic cancer cells by penicillin G.
abstract: Cancer, despite all the efforts, still causes one in five deaths worldwide. Surgery, chemotherapy and radiotherapy provide inadequate protection and instead affect normal cells along with cancer cells. The search for cancer cures from natural products (plants and animals) has been practice for over a decade and the use of purified chemical to treat cancer still continues. Several studies have been undertaken during last three decades to find the anti-cancerous property of various plant extract and toxins secreted by animals and micro-organism. These lead to the discovery of several promising molecule having anticancer activity, some of which are in clinical trial and may emerged to be a potential future drug in cancer therapy. In this study we have used penicillin to evaluate its anti-cancer activity. It shown significant effects at cellular and molecular levels against growth of HeLa and K562 cell lines.
authors.affiliation: GNOU-I2IT Centre of Excellence for Advanced Education and Research, Pune, Maharashtra, India.
authors.forename: Aditya
authors.initials: A
authors.lastname: Banerjee
authors.forename: Meetu
authors.initials: M
authors.lastname: Dahiya
authors.forename: M T
authors.initials: MT
authors.lastname: Anand
authors.forename: Sudhir
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000235:genetics; D015153:Blotting, Western; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D010400:Penicillin G / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D014709:Vero Cells
chemical_list: D000900:Anti-Bacterial Agents; D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D010400:Penicillin G