title: The two faces of potent antitumor duocarmycin-based drugs: a structural dissection reveals disparate motifs for DNA versus aldehyde dehydrogenase 1 affinity.
authors.affiliation: Department Chemie, Center for Integrated Protein Science, Institute of Advanced Studies, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Wirth
authors.forename: Galina F
authors.initials: GF
authors.lastname: Pestel
authors.forename: Vanessa
authors.initials: V
authors.lastname: Ganal
authors.forename: Thomas
authors.initials: T
authors.lastname: Kirmeier
authors.forename: Ingrid
authors.initials: I
authors.lastname: Schuberth
authors.forename: Theo
authors.initials: T
authors.lastname: Rein
authors.forename: Lutz F
authors.initials: LF
authors.lastname: Tietze
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Sieber
mesh_terms: D000080924:Aldehyde Dehydrogenase 1 Family; D000477:Alkylating Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001688:Biological Products; D004247:DNA / Q000737:chemistry*; D000080890:Duocarmycins; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology*; D007527:Isoenzymes / Q000737:chemistry*; D040901:Proteomics; D011760:Pyrrolidinones / Q000008:administration & dosage / Q000494:pharmacology; D050697:Retinal Dehydrogenase / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000477:Alkylating Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D000080890:Duocarmycins; D007211:Indoles; D007527:Isoenzymes; D011760:Pyrrolidinones; D004247:DNA; D000080924:Aldehyde Dehydrogenase 1 Family; D050697:Retinal Dehydrogenase; C058289:duocarmycin A