title: Palladium-catalyzed addition of potassium aryltrifluoroborates to aliphatic nitriles: synthesis of alkyl aryl ketones, diketone compounds, and 2-arylbenzo[b]furans.
abstract: A palladium-catalyzed addition of potassium aryltrifluoroborates to aliphatic nitriles has been developed, leading to a wide range of alkyl aryl ketones with moderate to excellent yields. Moreover, several dinitriles (e.g., malononitrile, glutaronitrile, and adiponitrile) were applicable to this process for the construction of 1,3-, 1,5-, or 1,6-dicarbonyl compounds. The scope of the developed approach is successfully explored toward the one-step synthesis of 2-arylbenzo[b]furans via sequential addition and intramolecular annulation reactions. The methodology accepted a wide range of substrates and is applicable to library synthesis.
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
authors.forename: Xingyong
authors.initials: X
authors.lastname: Wang
authors.forename: Miaochang
authors.initials: M
authors.lastname: Liu
authors.forename: Long
authors.initials: L
authors.lastname: Xu
authors.forename: Qingzong
authors.initials: Q
authors.lastname: Wang
authors.forename: Jiuxi
authors.initials: J
authors.lastname: Chen
authors.forename: Jinchang
authors.initials: J
authors.lastname: Ding
authors.forename: Huayue
authors.initials: H
authors.lastname: Wu
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D001881:Borates / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D011188:Potassium / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D001881:Borates; D007659:Ketones; D009570:Nitriles; D009942:Organometallic Compounds; D010165:Palladium; C105430:benzofuran; D011188:Potassium