title: Structural elucidation of novel degradation product of brotizolam.
abstract: When the drug product of brotizolam (1) is decomposed according to the interview form and patent, hydrolysate (2) is obtained, but its physicochemical data are still missing. To elucidate the structure based on a spectroscopic approach, the above-mentioned degradation product was isolated and applied to the structural analysis. As a result, the structure of decomposed product was found to be different from that of 2. In this report, its isolation and structure elucidation by NMR and MS spectra are described.
authors.affiliation: Sanyo Chemical Laboratory Co., Ltd, Tajii, Sakai-shi, Osaka 587-0012, Japan. sugimoto@sanyokagaku.co.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sugimoto
authors.forename: Aya
authors.initials: A
authors.lastname: Kugimiya
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Yoshimura
authors.forename: Hideo
authors.initials: H
authors.lastname: Naoki
mesh_terms: D001381:Azepines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods
chemical_list: D001381:Azepines; C020960:brotizolam