title: Gene-expression differences in peripheral blood between lithium responders and non-responders in the Lithium Treatment-Moderate dose Use Study (LiTMUS).
abstract: This study was designed to identify genes whose expression in peripheral blood may serve as early markers for treatment response to lithium (Li) in patients with bipolar disorder. Although changes in peripheral blood gene-expression may not relate directly to mood symptoms, differences in treatment response at the biochemical level may underlie some of the heterogeneity in clinical response to Li. Subjects were randomized to treatment with (n=28) or without (n=32) Li. Peripheral blood gene-expression was measured before and 1 month after treatment initiation, and treatment response was assessed after 6 months. In subjects treated with Li, 62 genes were differentially regulated in treatment responders and non-responders. Of these, BCL2L1 showed the greatest difference between Li responders and non-responders. These changes were specific to Li responders (n=9), and were not seen in Li non-responders or patients treated without Li, suggesting that they may have specific roles in treatment response to Li.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Beech
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Leffert
authors.affiliation: Keck Foundation Biotechnology Biostatistics Resource, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: A
authors.initials: A
authors.lastname: Lin
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: L G
authors.initials: LG
authors.lastname: Sylvia
authors.affiliation: Center for Genome Analysis, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: S
authors.initials: S
authors.lastname: Umlauf
authors.affiliation: Center for Genome Analysis, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: S
authors.initials: S
authors.lastname: Mane
authors.affiliation: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Departments of Psychiatry and Pharmacology, University of Texas Health Science, San Antonio, TX, USA.
authors.forename: C
authors.initials: C
authors.lastname: Bowden
authors.affiliation: Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Calabrese
authors.affiliation: Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Friedman
authors.affiliation: Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Ketter
authors.affiliation: Departments of Psychiatry and Neuroscience, Mount Sinai Medical Center, New York, NY, USA.
authors.forename: D V
authors.initials: DV
authors.lastname: Iosifescu
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: N A
authors.initials: NA
authors.lastname: Reilly-Harrington
authors.affiliation: Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Ostacher
authors.affiliation: Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Thase
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Nierenberg
mesh_terms: D001714:Bipolar Disorder / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D001798:Blood Proteins / Q000096:biosynthesis; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D008094:Lithium / Q000008:administration & dosage*; D008297:Male; D051020:bcl-X Protein / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C494811:BCL2L1 protein, human; D001798:Blood Proteins; D051020:bcl-X Protein; D008094:Lithium