title: Transcriptional repression of BODENLOS by HD-ZIP transcription factor HB5 in Arabidopsis thaliana.
abstract: In Arabidopsis thaliana, the phytohormone auxin is an important patterning agent during embryogenesis and post-embryonic development, exerting effects through transcriptional regulation. The main determinants of the transcriptional auxin response machinery are AUXIN RESPONSE FACTOR (ARF) transcription factors and AUXIN/INDOLE-3-ACETIC ACID (AUX/IAA) inhibitors. Although members of these two protein families are major developmental regulators, the transcriptional regulation of the genes encoding them has not been well explored. For example, apart from auxin-linked regulatory inputs, factors regulating the expression of the AUX/IAA BODENLOS (BDL)/IAA12 are not known. Here, it was shown that the HOMEODOMAIN-LEUCINE ZIPPER (HD-ZIP) transcription factor HOMEOBOX PROTEIN 5 (HB5) negatively regulates BDL expression, which may contribute to the spatial control of BDL expression. As such, HB5 and probably other class I HD-ZIP proteins, appear to modulate BDL-dependent auxin response.
authors.affiliation: Department of Cell Biology, Max Planck Institute for Developmental Biology, D-72076 Tübingen, Germany.
authors.forename: Ive
authors.initials: I
authors.lastname: De Smet
authors.forename: Steffen
authors.initials: S
authors.lastname: Lau
authors.forename: Jasmin S
authors.initials: JS
authors.lastname: Ehrismann
authors.forename: Ioannis
authors.initials: I
authors.lastname: Axiotis
authors.forename: Martina
authors.initials: M
authors.lastname: Kolb
authors.forename: Marika
authors.initials: M
authors.lastname: Kientz
authors.forename: Dolf
authors.initials: D
authors.lastname: Weijers
authors.forename: Gerd
authors.initials: G
authors.lastname: Jürgens
mesh_terms: D017360:Arabidopsis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D015536:Down-Regulation; D018506:Gene Expression Regulation, Plant; D018398:Homeodomain Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D007210:Indoleacetic Acids / Q000378:metabolism; D016350:Leucine Zippers; D010937:Plant Growth Regulators / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: C473146:ATHB5 protein, Arabidopsis; D029681:Arabidopsis Proteins; D018398:Homeodomain Proteins; C527433:IAA12 protein, Arabidopsis; D007210:Indoleacetic Acids; D010937:Plant Growth Regulators; D012097:Repressor Proteins; D014157:Transcription Factors
keywords: Arabidopsis; BODENLOS (BDL); HOMEOBOX PROTEIN 5 (HB5); auxin; embryo; transcriptional regulation.