title: Long Term Persistence of IgE Anti-Varicella Zoster Virus in Pediatric and Adult Serum Post Chicken Pox Infection and after Vaccination with Varicella Virus Vaccine.
abstract: The production of IgE specific to different viruses (HIV-1, Parvovirus B19, RSV), and the ability for IgE anti-HIV-1 to suppress HIV-1 production in vitro, strongly suggest an important role for IgE and/or anti viral specific IgE in viral pathogenesis. Previous studies in our laboratory were the first to report the presence of IgE anti-varicella zoster virus (VZV) in an adolescent patient with shingles. However, the presence and long term persistence of IgE anti VZV antibodies has not been studied in adults. The presence of serum IgE in addition to IgE and IgG anti-VZV antibody in sera were studied in children (N=12) (0-16 y/o) and adults (N=9) (32-76 y/o) with either a past history of (wild type) chicken pox (N=7 children, 9 adults) or 5 years after vaccination with varicella zoster (N=2 children) (Varicella virus vaccine live, Oka/Merck), as well as in non-infected subjects (N=3 children). Of the patients who had a positive history of chicken pox 13 of 16 (81%) contained IgE anti-VZV antibodies; they were both serum IgEHi (>100 IU/ml) and IgELo (<100 IU/ml). Of the patients who were vaccinated, IgE anti-VZV antibodies were undetected. In contrast, serum from the patients without a history of chicken pox or vaccination did not make either IgE or IgG anti-VZV antibodies. This is the first demonstration of the existence of IgE anti-VZV antibodies, and its long-term persistence in serum of previously infected subjects. Future studies regarding the functional role of anti-viral IgE and its relationship to VZV are warranted.
authors.affiliation: Departments of Pediatrics, Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, New York, USA;
authors.forename: Tamar A
authors.initials: TA
authors.lastname: Smith-Norowitz
authors.forename: Joby
authors.initials: J
authors.lastname: Josekutty
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Silverberg
authors.forename: Hadar
authors.initials: H
authors.lastname: Lev-Tov
authors.forename: Yitzchok M
authors.initials: YM
authors.lastname: Norowitz
authors.forename: Stephan
authors.initials: S
authors.lastname: Kohlhoff
authors.forename: Maja
authors.initials: M
authors.lastname: Nowakowski
authors.forename: Helen G
authors.initials: HG
authors.lastname: Durkin
authors.forename: Martin H
authors.initials: MH
authors.lastname: Bluth
keywords: IgE; varicella zoster virus; varicella zoster virus vaccine