title: Appropriateness of blood product transfusion in the Obstetrics and Gynaecology (O&G) department of a tertiary hospital in West Africa.
abstract: BACKGROUND
  Misuse of blood by clinicians was suggested to explain blood shortage in sub-Saharan Africa although based on little evidence. This study evaluated whether routine halving (restricted) of blood requests was justified.
  
  
  METHODS
  On alternated days for 3 months in 2011-2012, restricted or full blood product supply [whole blood (WB), red cell concentrate (RCC)] was provided to the Obstetrics & Gynaecology department (O&G). Patient age, haemoglobin (Hb) level pre- and post-transfusion, clinical condition, blood products request and supply, transfused and returned, clinical outcome were collated.
  
  
  RESULTS
  Five hundred and nineteen patients (249 restricted and 270 full supply) received 1001 blood products (94.6% WB, 6.4% RCC). Clinical conditions were severe peri-partum bleeding (72.4%) requiring emergency transfusion (82%) whilst 27.6% of total transfusion was for anaemia, 18% being moderate (8-10 g dL(-1) ). Pre-transfusion Hb level was <6 g dL(-1) in 36.7%, 6-8 g dL(-1) 29.1% and ≥ 8 g dL(-1) in 33.2% of cases. Fifty-five percent of the transfused blood was stored ≤ 1 week. Restricted supply triggered additional request (40%) compared to 10% in full supply mode. Whether with restricted or full supply, blood requests, supply and units transfused/patient were similar (restricted 2.3 and 2.1 unit patient(-1) and full 2.9 and 2.3 unit patient(-1) , respectively). Fatal clinical outcome was 3.1% evenly distributed between supply modes and transfusion reactions 0.8%.
  
  
  CONCLUSIONS
  O&G clinicians order blood according to clinical need and transfuse 85% of the products supplied. Product supply did not significantly affect use although appropriateness of transfusion was difficult to assess.
authors.affiliation: Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
authors.forename: E N
authors.initials: EN
authors.lastname: Osei
authors.forename: A T
authors.initials: AT
authors.lastname: Odoi
authors.forename: S
authors.initials: S
authors.lastname: Owusu-Ofori
authors.forename: J-P
authors.initials: JP
authors.lastname: Allain
mesh_terms: D000354:Africa, Western; D016913:Blood Component Transfusion / Q000009:adverse effects / Q000592:standards*; D005260:Female; D006801:Humans; D009775:Obstetrics and Gynecology Department, Hospital; D011446:Prospective Studies; D062606:Tertiary Care Centers