title: Hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of thioethers and ethers from quinazolin-4(3H)-ones.
abstract: A hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of quinazoline (thio)ethers from quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, diisopropylethylamine (DIPEA), and thiophenols resulted in formation of the corresponding 4-arylthioquinazoline derivatives in moderate to excellent yields. This method has also been utilized to prepare 4-aryloxyquinazoline and 4-alkoxyquinazoline derivatives using phenols and sodium alkoxides as the nucleophiles.
authors.affiliation: State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Baoxiang
authors.initials: B
authors.lastname: Hu
authors.forename: Xiaochu
authors.initials: X
authors.lastname: Zhang
authors.forename: Lili
authors.initials: L
authors.lastname: Sheng
authors.forename: Ming
authors.initials: M
authors.lastname: Guo
authors.forename: Zhenlu
authors.initials: Z
authors.lastname: Shen
authors.forename: Xinquan
authors.initials: X
authors.lastname: Hu
authors.forename: Nan
authors.initials: N
authors.lastname: Sun
authors.forename: Weimin
authors.initials: W
authors.lastname: Mo
mesh_terms: D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry*; D010753:Phosphoranes / Q000737:chemistry*; D011799:Quinazolines / Q000737:chemistry*
chemical_list: D004987:Ethers; D010753:Phosphoranes; D011799:Quinazolines; C022601:hexachlorocyclotriphosphazene