title: Anti-reflux surgery for patients with esophageal atresia.
abstract: Gastroesophageal reflux (GER) is almost constant in esophageal atresia and tracheoesophageal fistula (EA/TEF). These patients resist medical treatment and require antireflux surgery quite often. The present review examines why this happens, the long-term consequences of GER and the main indications and results of fundoplication in this particular group of patients. The esophagus of EA/TEF patients is malformed and has abnormal extrinsic and intrinsic innervation and, consequently, deficient sphincter function and dysmotility. These anomalies are permanent. Fifty percent of patients overall have GER, and one-fifth have Barrett's metaplasia. Close to 100%, GER of pure and long-gap cases require fundoplication. In the long run, these patients have 50-fold higher risk of carcinoma than the control population. GER in EA/TEF does not respond well to dietary, antacid, or prokinetic medication. Surgery is necessary in protracted anastomotic stenoses, in pure and long-gap cases, and when there is an associated duodenal atresia. It should be indicated as well in other symptomatic cases when conservative treatment fails. However, confection of a suitable wrap is anatomically difficult in this condition as shown by a failure rate of 30% that is also explained by the persistence for life of the conditions facilitating GER.
authors.affiliation: Department of Pediatric Surgery, La Paz University Hospital, Autonomous University of Madrid, 28046 Madrid, Spain. juan.tovar@salud.madrid.org
authors.forename: J A
authors.initials: JA
authors.lastname: Tovar
authors.forename: A C
authors.initials: AC
authors.lastname: Fragoso
mesh_terms: D004933:Esophageal Atresia / Q000150:complications*; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000601:surgery*; D006801:Humans; D014138:Tracheoesophageal Fistula / Q000150:complications*; D016896:Treatment Outcome