title: Interaction of tricationic corroles with single/double helix of homopolymeric nucleic acids and DNA.
abstract: In this manuscript a multitechnique approach is proposed to characterize the interaction between new tri-N-methylpyridyl corrole (TMPC) and its germanium(IV) derivative (GeTMPC), with single- and double-stranded nucleic acid homopolymers and calf thymus DNA. The specificity of each spectroscopic technique has been exploited to analyze the different aspects of corrole binding. Noteworthy, this approach allows us to distinguish between H aggregation of TMPC in the presence of polyriboadenilic acid (poly(rA)) and J aggregates in the presence of polyribocytidinic acid (poly(rC)) as well as to identify the formation of GeTMPC dimers in the presence of single-stranded poly(rA) and pseudointercalation with single-stranded poly(rC).
authors.affiliation: Department of Chemical Science, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: D'Urso
authors.forename: Sara
authors.initials: S
authors.lastname: Nardis
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pomarico
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Fragalà
authors.forename: Roberto
authors.initials: R
authors.lastname: Paolesse
authors.forename: Roberto
authors.initials: R
authors.lastname: Purrello
mesh_terms: D002412:Cations / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D005857:Germanium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011131:Polyribonucleotides / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*
chemical_list: D002412:Cations; D009942:Organometallic Compounds; D011131:Polyribonucleotides; D011166:Porphyrins; C431863:corrole; D005857:Germanium; D004247:DNA