title: Construction of optically active indolines by formal [4+1] annulation of sulfur ylides and N-(ortho-chloromethyl)aryl amides.
abstract: Get asymmetric! Asymmetric [4+1] annulation of sulfur ylides and N-(ortho-chloromethyl)aryl amides allowed the formation of the desired cycloadduct with moderate to high yields and enantioselectivities (see scheme). The described strategy, taking advantage of chiral sulfur ylides, represents a direct procedure to access chiral 2-substituted indolines.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, PR China.
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Yang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: An
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Chen
authors.forename: Liang-Qiu
authors.initials: LQ
authors.lastname: Lu
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Xiao
mesh_terms: D000577:Amides / Q000737:chemistry*; D018360:Crystallography, X-Ray; D061565:Cycloaddition Reaction; D007211:Indoles / Q000737:chemistry*; D008968:Molecular Conformation; D013237:Stereoisomerism; D013455:Sulfur / Q000737:chemistry*
chemical_list: D000577:Amides; D007211:Indoles; C057812:indoline; D013455:Sulfur