title: [Clinical treatment of diabetes mellitus complicated with chronic osteomyelitis].
abstract: OBJECTIVE
  To investigate treatment methods for diabetes complicated with chronic osteomyelitis.
  
  
  METHODS
  The clinical data of 39 diabetic patients with chronic osteomyelitis from 2000 to 2011 were studied. Among the patients, 23 patients were male and 16 patients were female,ranging in age from 21 to 81 years old,with a mean of 45 years old. All the patients had symptoms such as red,swelling,hot and pain to different degrees,and the duration of the disease lasted over more than 3 months,among which,25 patients had preoperative sinus formation. Routine preoperative drainage fluid culture, X-ray and CT examination were performed. Twenty-seven patients underwent debridement, one stage bone grafting and external fixation; 12 patients underwent debridement and antibiotic treatment. The examination results of ESR, CRP and blood routine before and after treatment were compared to evaluate clinical effects.
  
  
  RESULTS
  After treatment, the values of ESR(preoperative 35 patients with higher value, and postoperative 32 patients with normal value), blood routine (preoperative 25 patients with abnormal value,and postoperative 23 patients with normal value), and CRP(preoperative 36 patients with higher value, and postoperative 33 patients with normal value) all improved. The liquor puris cultures were negative after treatment. Among 39 patients, 33 patients had clinical cure; 6 patients recurred within 4 months to 4 years.
  
  
  CONCLUSIONS
  The treatment of diabetes should be paid attention when the chronic osteomyelitis was treated,and the combination treatment can significantly improve the cure rate of diabetes complicated with chronic osteomyelitis.
authors.affiliation: Nanjing University Clinical School of Medicine ,Nanjing General Hospital of Nanjing Military Region, Nanjing 210000, Jiangsu, China.
authors.forename: Cheng-Long
authors.initials: CL
authors.lastname: Liu
authors.forename: Ting
authors.initials: T
authors.lastname: Guo
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Jian-Ning
authors.initials: JN
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002908:Chronic Disease; D003646:Debridement; D048909:Diabetes Complications / Q000628:therapy*; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents; D007328:Insulin