title: Route to pyrazolo[5,1-a]isoquinolines via a copper-catalyzed tandem reaction of 2-alkynylbromobenzene with pyrazole.
abstract: A copper-catalyzed tandem reaction of 2-alkynylbromobenzene and pyrazole is described that provides a facile route to pyrazolo[5,1-a]isoquinolines in good yields. During the reaction process, copper(I)-catalyzed hydroamination and C-H activation are involved.
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Pan
authors.forename: Yong
authors.initials: Y
authors.lastname: Luo
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
mesh_terms: D001969:Bromobenzenes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: D001969:Bromobenzenes; D007546:Isoquinolines; D011720:Pyrazoles; C031280:pyrazole; D003300:Copper