title: Paroxetine hydrochloride.
abstract: Paroxetine hydrochloride (3S-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine hydrochloride (or (-)-(3S,4R)-(4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)-phenoxy]methyl]piperidine hydrochloride), a phenylpiperidine derivative, is a selective serotonin reuptake inhibitor. Paroxetine is indicated for the treatment of depression, generalized anxiety disorder, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, and social anxiety disorder. The physicochemical properties, spectroscopic data (1D and 2D NMR, UV, FT-IR, MS, PXRD), stability, methods of preparation and chromatographic methods of analysis of pharmaceutical, and biological samples of paroxetine are documented in this review. Pharmacokinetics, metabolism, and pharmacological effects are also discussed.
authors.affiliation: Apotex Inc., Toronto, Ontario, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Germann
authors.forename: George
authors.initials: G
authors.lastname: Ma
authors.forename: Feixue
authors.initials: F
authors.lastname: Han
authors.forename: Anna
authors.initials: A
authors.lastname: Tikhomirova
mesh_terms: D000818:Animals; D002845:Chromatography; D004355:Drug Stability; D006801:Humans; D017374:Paroxetine / Q000032:analysis* / Q000737:chemistry / Q000493:pharmacokinetics; D017367:Selective Serotonin Reuptake Inhibitors / Q000032:analysis*; D013057:Spectrum Analysis
chemical_list: D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors