title: [Development of hemostatic sealant for arterial anastomosis; clinical application].
abstract: For the purpose of examining the clinical applicability of a newly developed surgical sealant, animal experiments were performed, and clinical trial was followed. In animal experiments, several animal models, including carotid artery anastomosis model and coronary artery bypass grafting model were undertaken. In each model, complete hemostasis of the anastomoses using four simple interrupted sutures, was obtained. In addition, elastomeric property of the sealant prevented thinning of the arterial wall. The clinical trial performed in patients with thoracic aortic surgery showed significantly better hemostasis even under heparinized condition. Based on these excellent results, clinical usage of the sealant was approved.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Saga University, Saga, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Morita
authors.forename: Takehisa
authors.initials: T
authors.lastname: Matsuda
authors.forename: Masataka
authors.initials: M
authors.lastname: Eto
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Oda
authors.forename: Ryuji
authors.initials: R
authors.lastname: Tominaga
mesh_terms: D000818:Animals; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery; D001158:Arteries / Q000601:surgery*; D004285:Dogs; D006489:Hemostatic Techniques / Q000295:instrumentation*; D006801:Humans; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D014014:Tissue Adhesives