title: The expression of histone deacetylase 1, but not other class I histone deacetylases, is significantly increased in endometriosis.
abstract: Class I histone deacetylases (HDACs-1-3) play an important role in steroid hormone-dependent gene expression and in modulating cell survival and proliferation. We analyzed their expression in a tissue microarray including 74 endometriosis samples and 30 normal endometrium controls. The mean HDAC-1 immunoreactivity score (IRS ± standard deviation) was 7.6 ± 2.5 in endometriosis and 5.3 ± 2.3 in normal endometrium (P < .001). In contrast, the IRSs of HDAC-2 and -3 were 11.7 ± 0.7 and 11.8 ± 1.1 in endometriosis and 11.6 ± 1.0 and 11.9 ± 0.4 in normal endometrium (P = .7 and P = .2), respectively. Significant correlations were found between HDAC-1 and estrogen (-alpha/-beta) and progesterone receptor expression. In conclusion, HDAC-1, but not HDAC-2/-3, was significantly increased in endometriosis and associated with steroid hormone receptor expression that may reflect interdependence. In context with the literature, specific inhibitors of HDAC-1 may have inhibitory activities similar to those of broad-spectrum HDAC inhibitors and may be clinically tolerated, which would increase their chance as an option in the treatment of endometriosis.
authors.affiliation: 1Division of Gynecology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Eleftherios P
authors.initials: EP
authors.lastname: Samartzis
authors.forename: Aurelia
authors.initials: A
authors.lastname: Noske
authors.forename: Nicolas
authors.initials: N
authors.lastname: Samartzis
authors.forename: Daniel
authors.initials: D
authors.lastname: Fink
authors.forename: Patrick
authors.initials: P
authors.lastname: Imesch
mesh_terms: D016022:Case-Control Studies; D004715:Endometriosis / Q000201:enzymology*; D047628:Estrogen Receptor alpha / Q000032:analysis; D047629:Estrogen Receptor beta / Q000032:analysis; D005260:Female; D056284:Histone Deacetylase 1 / Q000032:analysis*; D056464:Histone Deacetylase 2 / Q000032:analysis; D006655:Histone Deacetylases / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D011980:Receptors, Progesterone / Q000032:analysis; D046888:Tissue Array Analysis; D015854:Up-Regulation; D000099186:Histone Deacetylase 3
chemical_list: D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D056284:Histone Deacetylase 1; D056464:Histone Deacetylase 2; D006655:Histone Deacetylases; D011980:Receptors, Progesterone; D000099186:Histone Deacetylase 3; C506487:ESR1 protein, human; C110550:HDAC1 protein, human; C533423:HDAC2 protein, human
keywords: endometriosis; estrogen and progesterone receptor; histone deacetylases class I