title: Intravenous levetiracetam for treatment of neonatal seizures.
abstract: In this case series we report on eight neonates with refractory seizures who received intravenous levetiracetam when seizures did not respond to two or more conventional anticonvulsants. Six of the eight neonates had an excellent response with either cessation, or reduction in seizures by at least 80%. One neonate showed a partial response while one did not have any reduction in seizure frequency. We did not encounter any adverse effects that could be attributable to levetiracetam.
authors.affiliation: Department of Neonatal Paediatrics, Princess Margaret Hospital for Children and King Edward Memorial Hospital for Women, Perth, Australia.
authors.forename: Abhijeet
authors.initials: A
authors.lastname: Rakshasbhuvankar
authors.forename: Shripada
authors.initials: S
authors.lastname: Rao
authors.forename: Rolland
authors.initials: R
authors.lastname: Kohan
authors.forename: Karen
authors.initials: K
authors.lastname: Simmer
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Nagarajan
mesh_terms: D061605:Administration, Intravenous; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D004569:Electroencephalography / Q000295:instrumentation / Q000379:methods; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D000077287:Levetiracetam; D010889:Piracetam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D012640:Seizures / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam
keywords: Anticonvulsants; Levetiracetam; Newborn; Seizures