title: ACTN3 R577X polymorphism and explosive leg-muscle power in elite basketball players.
abstract: OBJECTIVE
  To determine the association of the ACTN3 R577X polymorphism with leg-muscle explosive power in Spanish (white) elite basketball players and controls.
  
  
  METHODS
  100 (60 men) elite basketball players (cases) and 283 nonathletic controls.
  
  
  METHODS
  The authors assessed power performance by means of the vertical-squat and countermovement-jump tests.
  
  
  RESULTS
  Genotype distributions did not differ between groups (cases: 37.0% [RR], 42.0% [RX], and 21.0% [XX]; controls: 31.8% [RR], 49.8% [RX], and 18.4% [XX]; P = .353). The authors did not observe any effect of the ACTN3 R577X polymorphism on study phenotypes in either group, including when they performed the analyses separately in men and women. They found no association between the ACTN3 R577X polymorphism and the likelihood of being an elite basketball player using the dominant or the recessive model, and the results remained unaltered when the analyses were adjusted for sex, weight, height, and age or when performed for men and women separately.
  
  
  CONCLUSIONS
  Although the ACTN3 R577X is associated with explosive muscle performance and this phenotype is important in the sport of basketball (ie, during jumps), the authors found no association with leg explosive power in elite basket players or with the status of being this type of athlete.
authors.affiliation: Faculty of Health and Sport Science, University of Zaragoza, Huesca, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Garatachea
authors.forename: Zoraida
authors.initials: Z
authors.lastname: Verde
authors.forename: Alejandro
authors.initials: A
authors.lastname: Santos-Lozano
authors.forename: Thomas
authors.initials: T
authors.lastname: Yvert
authors.forename: Gabriel
authors.initials: G
authors.lastname: Rodriguez-Romo
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Sarasa
authors.forename: Sonsoles
authors.initials: S
authors.lastname: Hernández-Sánchez
authors.forename: Catalina
authors.initials: C
authors.lastname: Santiago
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
mesh_terms: D000185:Actinin / Q000235:genetics*; D000328:Adult; D000704:Analysis of Variance; D054874:Athletic Performance; D001490:Basketball; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D009119:Muscle Contraction / Q000235:genetics*; D053580:Muscle Strength / Q000235:genetics*; D018482:Muscle, Skeletal / Q000502:physiology*; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D013030:Spain; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: C118456:ACTN3 protein, human; D000185:Actinin