title: [A new physiopathological classification of diabetic neuropathy].
abstract: Nowadays, Diabetic Neuropathy (DN) is considered the most common cause of peripheral neuropathy in clinical practice. It can affect sensitive, motor or autonomic nerve fibers, with symmetric, asymmetric, acute or chronic presentations. Due to this variability, with multiple physiopathologic mechanisms involved, a complex clinical classification has been used until recently. The aim of this review is to present a new classification of diabetic neuropathy, based on its physiopathology. It is divided in metabolic microvascular and hypoxic, autoimmune and inflammatory, compressive, secondary to complications of diabetes and related to treatment. It must be understood that DN is not just a functional disease, but a complication of diabetes with molecular and pathological substrates caused by hyperglycemia. Therefore, normalization of blood glucose is a fundamental step towards the successful prevention and treatment of DN.
authors.affiliation: Departamento de Ingeniería Eléctrica, Facultad de Ingeniería, Pontificia Universidad Católica de Chile, Chile. polmos@med.puc.cl
authors.forename: Pablo R
authors.initials: PR
authors.lastname: Olmos
authors.forename: Sergio
authors.initials: S
authors.lastname: Niklitschek
authors.forename: Roberto I
authors.initials: RI
authors.lastname: Olmos
authors.forename: Jorge I
authors.initials: JI
authors.lastname: Faúndez
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Quezada
authors.forename: Milan A
authors.initials: MA
authors.lastname: Bozinovic
authors.forename: Ian A
authors.initials: IA
authors.lastname: Niklitschek
authors.forename: Jorge
authors.initials: J
authors.lastname: Acosta
authors.forename: Claudio N
authors.initials: CN
authors.lastname: Valencia
authors.forename: Felipe A
authors.initials: FA
authors.lastname: Bravo
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000145:classification* / Q000503:physiopathology; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology