title: AMPK connects energy stress to PIK3C3/VPS34 regulation.
abstract: The class III phosphatidylinositol (PtdIns)-3 kinase, PIK3C3/VPS34, forms multiple complexes and regulates a variety of cellular functions, especially in intracellular vesicle trafficking and autophagy. Even though PtdIns3P, the product of PIK3C3, is thought to be a critical membrane marker for the autophagosome, it is unclear how PIK3C3 is regulated in response to autophagy-inducing stimuli. A complexity of PIK3C3 biology is due in part to the existence of multiple complexes, of which the ATG14- or UVRAG-containing complexes play important roles in autophagy. We recently discovered differential regulation of distinct PIK3C3 complexes in response to energy starvation and showed a mechanism by which AMPK directly phosphorylates PIK3C3 and BECN1 to regulate non- and pro-autophagic PIK3C3 complexes, respectively.
authors.affiliation: Department of Oral Biochemistry and Molecular Biology; Research Center for Tooth and Periodontal Tissue Regeneration; School of Dentistry; Kyung Hee University; Seoul, Korea.
authors.forename: Joungmok
authors.initials: J
authors.lastname: Kim
authors.forename: Kun-Liang
authors.initials: KL
authors.lastname: Guan
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000818:Animals; D058546:Class III Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000166:cytology; D004734:Energy Metabolism; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D051379:Mice; D008954:Models, Biological; D013312:Stress, Physiological
chemical_list: D058546:Class III Phosphatidylinositol 3-Kinases; D055372:AMP-Activated Protein Kinases
keywords: AMPK; ATG14; BECN1; VPS34 complexes; autophagy