title: Palliative treatment of presacral recurrence of endometrial cancer using irreversible electroporation: a case report.
abstract: BACKGROUND
  Irreversible electroporation (IRE) is a new minimally invasive tumor ablation technique which induces irreversible disruption of cell membrane integrity by changing the transmembrane potential resulting in cell death. Irreversible electroporation is currently undergoing clinical investigation as local tumor therapy for malignant liver and lung lesions. This is the first case report to describe the successful palliative ablation of a presacral recurrence of an endometrial cancer to achieve locoregional tumor control and pain relief.
  
  
  METHODS
  A 56-year-old Caucasian woman was referred for interventional treatment of an advanced local recurrence of endometrial cancer (11.9 × 11.6 × 14.9cm) with infiltration of the sacral bone and nerve plexus. Due to the immediate proximity to the sacral plexus, the patient could neither undergo surgical therapy nor a second radiation therapy. Due to its ablation mechanism irreversible electroporation was deemed to be the best therapy option.
  
  
  CONCLUSIONS
  We showed in this case that a large tumor mass adjacent to a bundle of neural structures, the sacral plexus, can be widely ablated by irreversible electroporation with only minor temporary impairment of the neural function, even though a large infiltrating tissue volume (941cm3) was ablated.
authors.affiliation: Department of Radiology, University Hospital Regensburg, Franz-Josef Strauss Allee 11, Regensburg, 93042, Germany. christoph.niessen@klinik.uni-regensburg.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Niessen
authors.forename: Ernst-Michael
authors.initials: EM
authors.lastname: Jung
authors.forename: Andreas G
authors.initials: AG
authors.lastname: Schreyer
authors.forename: Walter A
authors.initials: WA
authors.lastname: Wohlgemuth
authors.forename: Benedikt
authors.initials: B
authors.lastname: Trabold
authors.forename: Joachim
authors.initials: J
authors.lastname: Hahn
authors.forename: Michael
authors.initials: M
authors.lastname: Rechenmacher
authors.forename: Christian
authors.initials: C
authors.lastname: Stroszczynski
authors.forename: Philipp
authors.initials: P
authors.lastname: Wiggermann