title: [Autologous stem cell transplantation for adult patients with acute lymphoblastic leukemia and related prognostic factors].
abstract: OBJECTIVE
  This study was aimed to observe the efficacy of autologous stem cell transplantation (ASCT) for adult patients with acute lymphoblastic leukemia (ALL), and investigate related prognostic factors.
  
  
  METHODS
  A total of 86 adult ALL patients underwent ASCT in Institute of Hematology and Blood Disease Hospital from November 2001 to January 2012 were followed up. Clinical characteristics and outcomes of all patients were retrospectively analyzed. Survival and univariate prognosis were analyzed by the Kaplan-Meier method and multivariate analysis by COX regression model.
  
  
  RESULTS
  Outcomes were assessed in 81 cases, including 47 standard-risk and 34 high-risk patients. 1-, 3-, 5-, and 10-year leukemia-free survival (LFS) of standard-risk patients were (82.3±5.7)%, (76.9±6.5)%, (74.1±6.8)%, (67.4±8.9)% respectively,and relapse rates (RR) were as of (13.6±5.2)%, (21.6±6.4)%, (24.5±6.8)%, (31.3±9.0)% respectively. 1-, 3-, 5-, and 10-year LFS of high-risk patients were (55.8±8.9)%, (39.8±9.3)%, (39.8±9.3)%, (39.8±9.3)% respectively, and relapse rates (RR) were (38.8±9.2)%, (56.4±10.0)%, (56.4±10.0)%, (56.4±10.0)% respectively. T-ALL, white blood cell count(WBC) more than 30×109/L when first visited, increased LDH, positive fusion gene of TCR and bone marrow transplantation were the adverse prognostic factors. Multivariate analysis showed bone marrow transplantation was an independent adverse prognostic factor.
  
  
  CONCLUSIONS
  ASCT was a choice for adult ALL patients when suitable donors were unavailable.
authors.affiliation: Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC Tianjin,China.
authors.forename: Shu-lian
authors.initials: SL
authors.lastname: Chen
authors.forename: Rong-li
authors.initials: RL
authors.lastname: Zhang
authors.forename: Jian-feng
authors.initials: JF
authors.lastname: Yao
authors.forename: Er-lie
authors.initials: EL
authors.lastname: Jiang
authors.forename: Qiao-ling
authors.initials: QL
authors.lastname: Ma
authors.forename: Ai-ming
authors.initials: AM
authors.lastname: Pang
authors.forename: Si-zhou
authors.initials: SZ
authors.lastname: Feng
authors.forename: Ming-zhe
authors.initials: MZ
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014182:Transplantation, Autologous; D055815:Young Adult