title: Hemophagocytosis by leukemic blasts in B lymphoblastic leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1): a case report.
abstract: Blasts showing hemophagocytosis have been very rarely reported in acute lymphoblastic leukemia. We report a pediatric case of B lymphoblastic leukemia (BLL) with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1) showing erythrophagocytosis and thrombophagocytosis by leukemic blasts. About 4% of the leukemic blasts in marrow aspirate smears showed phagocytosis of erythrocytes, platelets, or nuclear remnants in a 3-year-old Korean boy with a diagnosis of BLL. Conventional cytogenetics and molecular analysis revealed the presence of t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1). The patient responded well to chemotherapy and is in a state of complete remission.
authors.affiliation: Department of Pediatrics, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Jun Eun
authors.initials: JE
authors.lastname: Park
authors.forename: Il Joong
authors.initials: IJ
authors.lastname: Park
authors.forename: Young Ae
authors.initials: YA
authors.lastname: Lim
authors.forename: Wee Gyo
authors.initials: WG
authors.lastname: Lee
authors.forename: Sung Ran
authors.initials: SR
authors.lastname: Cho
mesh_terms: D002675:Child, Preschool; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics*; D020732:Cytogenetic Analysis; D004912:Erythrocytes / Q000502:physiology; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D023461:Myeloid Progenitor Cells / Q000502:physiology*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D010587:Phagocytosis / Q000502:physiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D056910:Republic of Korea; D014178:Translocation, Genetic / Q000235:genetics*; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D015514:Oncogene Proteins, Fusion; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein
keywords: aberration; acute lymphoblastic leukemia; cell phagocytosis; childhood ALL; chromosomal; gene rearrangement