title: Bioactive dimeric carbazole alkaloids from Murraya koenigii.
abstract: Phytochemical studies on the CHCl3 extract of the fruit pulp of Murraya koenigii afforded three new dimeric carbazole alkaloids, bisgerayafolines A-C (1-3). Bisgerayafolines A-C (1-3) are structurally unique dimeric carbazole alkaloids comprising geranyl moieties incorporated in their structures. Compounds 1-3 exhibited various levels of antioxidant, anti-α-glucosidase, DNA binding, and cytotoxic activities and protein interactions.
authors.affiliation: Department of Chemistry, School of Chemical Sciences, Bharathiar University, Coimbatore, 641 046, Tamil Nadu, India.
authors.forename: Chokkalingam
authors.initials: C
authors.lastname: Uvarani
authors.forename: Mathan
authors.initials: M
authors.lastname: Sankaran
authors.forename: Nanjundan
authors.initials: N
authors.lastname: Jaivel
authors.forename: Kumarasamy
authors.initials: K
authors.lastname: Chandraprakash
authors.forename: Athar
authors.initials: A
authors.lastname: Ata
authors.forename: Palathurai S
authors.initials: PS
authors.lastname: Mohan
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002725:Chloroform / Q000737:chemistry; D004247:DNA / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D065089:Glycoside Hydrolase Inhibitors; D045325:HCT116 Cells; D006367:HeLa Cells; D006801:Humans; D007194:India; D015394:Molecular Structure; D032101:Murraya / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D002227:Carbazoles; D065089:Glycoside Hydrolase Inhibitors; C583829:bisgerayafoline A; C583830:bisgerayafoline B; C583831:bisgerayafoline C; D002725:Chloroform; D004247:DNA