title: Pharmacogenomics and cardiovascular disease.
abstract: Variability in drug responsiveness is a sine qua non of modern therapeutics, and the contribution of genomic variation is increasingly recognized. Investigating the genomic basis for variable responses to cardiovascular therapies has been a model for pharmacogenomics in general and has established critical pathways and specific loci modulating therapeutic responses to commonly used drugs such as clopidogrel, warfarin, and statins. In addition, genomic approaches have defined mechanisms and genetic variants underlying important toxicities with these and other drugs. These findings have not only resulted in changes to the product labels but also have led to development of initial clinical guidelines that consider how to facilitate incorporating genetic information to the bedside. This review summarizes the state of knowledge in cardiovascular pharmacogenomics and considers how variants described to date might be deployed in clinical decision making.
authors.affiliation: Division of Clinical Pharmacology, Vanderbilt University School of Medicine, 1285 Medical Research Building IV, Nashville, TN 37232, USA. peter.e.weeke@vanderbilt.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Weeke
authors.forename: Dan M
authors.initials: DM
authors.lastname: Roden
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000235:genetics*; D000077144:Clopidogrel; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D011110:Polymorphism, Genetic; D017410:Practice Guidelines as Topic; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D002317:Cardiovascular Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014859:Warfarin; D000077144:Clopidogrel; D013988:Ticlopidine