title: [How safe is sedation in gastrointestinal endoscopy? A multicentre analysis of 388,404 endoscopies and analysis of data from prospective registries of complications managed by members of the Working Group of Leading Hospital Gastroenterologists (ALGK)].
abstract: BACKGROUND
  Gastrointestinal endoscopies are increasingly being carried out with sedation. All of the drugs used for sedation are associated with a certain risk of complications. Data currently available on sedation-associated morbidity and mortality rates are limited and in most cases have substantial methodological limitations. The aim of this study was to record severe sedation-associated complications in a large number of gastrointestinal endoscopies.
  
  
  METHODS
  Data on severe sedation-associated complications were collected on a multicentre basis from prospectively recorded registries of complications in the participating hospitals (median documentation period 27 months, range 9 - 129 months).
  
  
  RESULTS
  Data for 388,404 endoscopies from 15 departments were included in the study. Severe sedation-associated complications occurred in 57 patients (0.01 %). Forty-one percent of the complications and 50 % of all complications with a fatal outcome (10/20 patients) occurred during emergency endoscopies. In addition, it was found that 95 % of the complications and 100 % of all fatal complications affected patients in ASA class ≥ 3.
  
  
  CONCLUSIONS
  Including nearly 400,000 endoscopies, this study represents the largest prospective, multicenter record of the complications of sedation worldwide. The analysis shows that sedation is carried out safely in gastrointestinal endoscopy. The morbidity and mortality rates are much lower than previously reported in the literature in similar groups of patients. Risk factors for the occurrence of serious complications include emergency examinations and patients in ASA class ≥ 3.
authors.affiliation: Die Institutsangaben sind am Ende des Beitrags gelistet. angelika.behrens@hskwiesbaden.de
authors.forename: A
authors.initials: A
authors.lastname: Behrens
authors.forename: J
authors.initials: J
authors.lastname: Labenz
authors.forename: A
authors.initials: A
authors.lastname: Schuler
authors.forename: W
authors.initials: W
authors.lastname: Schröder
authors.forename: M
authors.initials: M
authors.lastname: Rünzi
authors.forename: R-U
authors.initials: RU
authors.lastname: Steinmann
authors.forename: C-R
authors.initials: CR
authors.lastname: de Mas
authors.forename: A
authors.initials: A
authors.lastname: Kreuzmayr
authors.forename: K
authors.initials: K
authors.lastname: Barth
authors.forename: M J
authors.initials: MJ
authors.lastname: Bahr
authors.forename: E
authors.initials: E
authors.lastname: Burmester
authors.forename: J F
authors.initials: JF
authors.lastname: Erckenbrecht
authors.forename: T
authors.initials: T
authors.lastname: Frieling
authors.forename: F L
authors.initials: FL
authors.lastname: Dumoulin
authors.forename: B
authors.initials: B
authors.lastname: Pfaffenbach
authors.forename: W
authors.initials: W
authors.lastname: Schepp
authors.forename: A
authors.initials: A
authors.lastname: Schneider
authors.forename: G
authors.initials: G
authors.lastname: Kleber
authors.forename: M
authors.initials: M
authors.lastname: Meiborg
authors.forename: S
authors.initials: S
authors.lastname: Böhm
authors.forename: C
authors.initials: C
authors.lastname: Dietrich
authors.forename: C F
authors.initials: CF
authors.lastname: Dietrich
authors.forename: U
authors.initials: U
authors.lastname: Gottschalk
authors.forename: C
authors.initials: C
authors.lastname: Ell
mesh_terms: D000328:Adult; D000368:Aged; D064420:Drug-Related Side Effects and Adverse Reactions / Q000401:mortality*; D016099:Endoscopy, Gastrointestinal / Q000401:mortality*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D061214:Patient Safety; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D006993:Hypnotics and Sedatives