title: Correlations between the level of high-sensitivity C-reactive protein and cardiovascular risk factors in Korean adults with cardiovascular disease or diabetes mellitus: the CALLISTO study.
abstract: OBJECTIVE
  We assessed the relationship between the level of high-sensitivity C-reactive protein (hsCRP) and cardiovascular risk factors in Korean adults.
  
  
  METHODS
  We reviewed 1,561 patients with cardiovascular disease or diabetes mellitus with hsCRP levels measured within the past year. Four cardiovascular risk groups were determined: low (<10%, 0-1 risk), moderate (<10%, >2 risk), high (10-20%) and very high (>20%) risk, according to the number of risk factors and the Framingham/NCEP ATP III risk score. The correlations between the hsCRP level and cardiovascular risk factors (age, smoking, hypertension, lipid profiles and familial history of premature coronary heart disease) were investigated.
  
  
  RESULTS
  The mean and median hsCRP (mg/L) levels were 1.32 ± 9.69 and 0.29 (range: 0.01-7.48), respectively. Men had a higher median level of hsCRP than women (p<0.001). The levels of hs CRP significantly increased from the low to the very high risk group (0.15, 0.23, 0.27 and 0.47, respectively) and were significantly correlated with age, the level of glycosylated hemoglobin, body mass index (BMI), the level of high-density lipoprotein cholesterol (HDL-C), the low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio, the LDL-C/total cholesterol (TC) ratio, the HDL-C/TC ratio, the HDL-C/triglyceride (TG) ratio and the TC/TG ratio. Neither smoking, the LDL-C level nor the TG level affected the hsCRP level. In a multivariate regression analysis, age, the HDL-C level, the LDL-C/TC ratio and BMI were found to be independently correlated with the hsCRP level.
  
  
  CONCLUSIONS
  There is a significant relationship between the degree of cardiovascular risk and the hsCRP level in Korean adults with cardiovascular disease or diabetes mellitus. Assessing the hsCRP levels may thus provide additive value in predicting cardiovascular risks.
authors.affiliation: Division of Cardiovascular Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Suk Min
authors.initials: SM
authors.lastname: Seo
authors.forename: Sang Hong
authors.initials: SH
authors.lastname: Baek
authors.forename: Hui Kyung
authors.initials: HK
authors.lastname: Jeon
authors.forename: Seok-Min
authors.initials: SM
authors.lastname: Kang
authors.forename: Dong-Soo
authors.initials: DS
authors.lastname: Kim
authors.forename: Woo-Shik
authors.initials: WS
authors.lastname: Kim
authors.forename: Hyung Seop
authors.initials: HS
authors.lastname: Kim
authors.forename: Seung Woon
authors.initials: SW
authors.lastname: Rha
authors.forename: Jong Seon
authors.initials: JS
authors.lastname: Park
authors.forename: In Whan
authors.initials: IW
authors.lastname: Seong
authors.forename: Young Keun
authors.initials: YK
authors.lastname: Ahn
authors.forename: Jung Han
authors.initials: JH
authors.lastname: Yoon
authors.forename: Tae Joon
authors.initials: TJ
authors.lastname: Cha
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000737:chemistry*; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000175:diagnosis; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000737:chemistry; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D056910:Republic of Korea; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D008055:Lipids