title: Atypical presentation of verrucous carcinoma: a case study and review of the literature.
abstract: Verrucous carcinoma is a slow-growing lesion that is most often found on the weight-bearing surface of the foot and should be considered in the differential diagnosis for chronic nonhealing wounds in the diabetic neuropathic population. Accurate diagnosis may be difficult initially and often requires repeat histopathologic evaluation by an experienced pathologist. Verrucous carcinoma can invade deeper tissues; however, extension to bone is a rare occurrence. The authors present a case report of an atypical verrucous carcinoma on the dorsal aspect of the foot and a review of the literature. Studies suggest that multiple therapies exist and recurrence does occur; however, this is less likely with wide excision and more so with Mohs' surgery. With a high clinical suspicion and thorough histopathologic exam, bone involvement and amputation may be avoided.
  
  
  METHODS
  Therapeutic, Level IV.
authors.affiliation: College of Podiatric Medicine, Western University of Health Sciences, Pomona, California 91766, USA. kpenera@gmail.com
authors.forename: Keith E
authors.initials: KE
authors.lastname: Penera
authors.forename: Karim A
authors.initials: KA
authors.lastname: Manji
authors.forename: Alex B
authors.initials: AB
authors.lastname: Craig
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Grootegoed
authors.forename: Troy R
authors.initials: TR
authors.lastname: Leaming
authors.forename: Garrett A
authors.initials: GA
authors.lastname: Wirth
mesh_terms: D000328:Adult; D018289:Carcinoma, Verrucous / Q000175:diagnosis* / Q000601:surgery; D017719:Diabetic Foot / Q000175:diagnosis; D003937:Diagnosis, Differential; D005528:Foot / Q000601:surgery*; D006801:Humans; D008297:Male; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000601:surgery
keywords: chronic wound; epithelioma cuniculatum; human papillomavirus (HPV); squamous cell carcinoma; verrucous carcinoma