title: Effect of Aggregated β-Amyloid (1-42) on Synaptic Plasticity of Hippocampal Dentate Gyrus Granule Cells in Vivo.
abstract: BACKGROUND
  Alzheimer's disease (AD) is a common neurodegenerative disorder in elderly people with an impairment of cognitive decline and memory loss. β-amyloid (Aβ) as a potent neurotoxic peptide has a pivotal role in the pathogenesis of AD. This disease begins with impairment in synaptic functions before developing into later neuro¬degeneration and neuronal loss. The aim of this study was to evaluate the synaptic plasticity and electrophysiological function of granule cells in hippocampal dentate gyrus (DG) after intracerebroventricular (i.c.v.) administration of aggregated Aβ (1-42) peptide in vivo.
  
  
  METHODS
  Animals were divided to control and Aβ (1-42) groups. Long-term potentia¬tion (LTP) in perforant path-DG synapses was assessed in order to investigate the effect of aggregated Aβ (1-42) on synaptic plasticity. Field excitatory post-synaptic potential (fEPSP) slope and population spike (PS) amplitude were measured.
  
  
  RESULTS
  Administration of Aβ (1-42) significantly decreased fEPSP slope and PS amplitude in Aβ (1-42) group comparing with the control group and had no effect on baseline activity of neurons.
  
  
  CONCLUSIONS
  The present study indicates that administration of aggregated form of Aβ (1-42) into the lateral ventricle effectively inhibits LTP in granular cells of the DG in hippocampus in vivo.
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Babri
authors.forename: Mohammad
authors.initials: M
authors.lastname: Amani
authors.forename: Gisou
authors.initials: G
authors.lastname: Mohaddes
authors.forename: Alireza
authors.initials: A
authors.lastname: Alihemmati
authors.forename: Hadi
authors.initials: H
authors.lastname: Ebrahimi
keywords: Dentate Gyrus; Long-Term Potentiation; Synaptic Plasticity; β-Amyloid