title: Copeptin concentrations are not elevated in gestational diabetes mellitus.
abstract: OBJECTIVE
  To investigate copeptin levels in women with GDM and women with uncomplicated pregnancies.
  
  
  METHODS
  This case-control study was conducted on 45 women with GDM and 40 women with uncomplicated pregnancies. The maternal serum levels of copeptin were measured with enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Copeptin levels were not different among groups (0.93 ± 0.75 vs. 1.15 ± 0.93 ng/ml, p: 0.24). HOMA-IR and insulin levels were significantly higher in woman with GDM when compared with control group (2.90 ± 1.88 vs. 1.91 ± 0.50, p: 0.002; 11.74 ± 6.43 vs. 8.52 ± 2.28, p: 0.004, respectively). The copeptin concentrations were significantly correlated with insulin levels and HOMA-IR values (r = 0.329 p = 0.002, r = 0.289 p = 0.007, respectively).
  
  
  CONCLUSIONS
  The present study shows that serum copeptin concentrations did not differ in woman with GDM and non-GDM patients. However, we found a significant correlation between copeptin and HOMA-IR. Future studies are needed with larger populations in gestational diabetic patients on copeptin secretion, metabolism and action.
authors.affiliation: Department of Obstetrics and Gynecology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Oncul
authors.forename: Abdullah
authors.initials: A
authors.lastname: Tuten
authors.forename: Mine
authors.initials: M
authors.lastname: Kucur
authors.forename: Metehan
authors.initials: M
authors.lastname: Imamoglu
authors.forename: Ozlem Balcı
authors.initials: OB
authors.lastname: Ekmekci
authors.forename: Abdullah Serdar
authors.initials: AS
authors.lastname: Acıkgoz
authors.forename: Rıza
authors.initials: R
authors.lastname: Madazlı
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D006020:Glycopeptides / Q000097:blood*; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D011247:Pregnancy
chemical_list: D006020:Glycopeptides; D007328:Insulin; C048197:copeptins