title: [Expression of parodontal tissue matrix metalloproteinases-1,2 in adolescent and their role in gingival pathology].
abstract: Expression of matrix mettaloproteinases-1,2 were determine immunohistochemistry in gingival mucosa cells in Adolescent groups aged 9-13 and 14-17 years. The material was collected in cohort group of 50 persons. Relative data base - stomatological status in 618 school children aged 9-17 years (304 girls and 314 boys). The MMP-1,2 levels were statistically higher in epitheliocytes, macrophages and capillaries endotheliocytes in all instances not depend on the sex and correlate with mucosa disease activity. It was found that MMP-1,2 expression were higher in prepubertal group. Activity of MMP-1, 2 in gingival mucosa was significantly elevated in female 14-17 years group, than those associated with group 9-13 years.
authors.forename: N B
authors.initials: NB
authors.lastname: Khimshiashvili
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D005881:Gingiva / Q000378:metabolism / Q000473:pathology; D005883:Gingival Crevicular Fluid / Q000378:metabolism*; D005891:Gingivitis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis*; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis*
chemical_list: D020778:Matrix Metalloproteinase 2; D020781:Matrix Metalloproteinase 1