title: Role of neuroinflammation in adult neurogenesis and Alzheimer disease: therapeutic approaches.
abstract: Neuroinflammation, a specialized immune response that takes place in the central nervous system, has been linked to neurodegenerative diseases, and specially, it has been considered as a hallmark of Alzheimer disease, the most common cause of dementia in the elderly nowadays. Furthermore, neuroinflammation has been demonstrated to affect important processes in the brain, such as the formation of new neurons, commonly known as adult neurogenesis. For this, many therapeutic approaches have been developed in order to avoid or mitigate the deleterious effects caused by the chronic activation of the immune response. Considering this, in this paper we revise the relationships between neuroinflammation, Alzheimer disease, and adult neurogenesis, as well as the current therapeutic approaches that have been developed in the field.
authors.affiliation: Department of Molecular Neurobiology, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
authors.forename: Almudena
authors.initials: A
authors.lastname: Fuster-Matanzo
authors.forename: María
authors.initials: M
authors.lastname: Llorens-Martín
authors.forename: Félix
authors.initials: F
authors.lastname: Hernández
authors.forename: Jesús
authors.initials: J
authors.lastname: Avila
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology*; D055495:Neurogenesis / Q000276:immunology*; D009474:Neurons / Q000276:immunology* / Q000378:metabolism