title: Targeted drug delivery in cancer cells with red-light photoactivated mesoporous silica nanoparticles.
abstract: Mesoporous nanoparticles for drug delivery would benefit significantly from further improvements in targeting efficiency and endosomal release. We present a system based on colloidal mesoporous silica nanoparticles with targeting-ligands and a red-light photosensitizer. This nanoparticle system provides spatial and temporal control of the release of drugs into the cytosol of cancer cells. Furthermore, the system presents a general platform since it can be loaded with different cargos and adapted for targeting of multiple cell types.
authors.affiliation: Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstrasse 5-13(E), 81377 Munich, Germany.
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Mackowiak
authors.forename: Alexandra
authors.initials: A
authors.lastname: Schmidt
authors.forename: Veronika
authors.initials: V
authors.lastname: Weiss
authors.forename: Christian
authors.initials: C
authors.lastname: Argyo
authors.forename: Constantin
authors.initials: C
authors.lastname: von Schirnding
authors.forename: Thomas
authors.initials: T
authors.lastname: Bein
authors.forename: Christoph
authors.initials: C
authors.lastname: Bräuchle
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D012822:Silicon Dioxide