title: Thiol-ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors.
abstract: Thiol-ene click chemistry has been applied for obtaining sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors incorporating sugar moieties. Most of these new compounds were moderate CA I inhibitors, effective CA II inhibitors, and low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms CA IX and XII.
authors.affiliation: Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM1-UM2, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France.
authors.forename: Mohamed-Chiheb
authors.initials: MC
authors.lastname: Saada
authors.forename: Joanna
authors.initials: J
authors.lastname: Ombouma
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Montero
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Winum
mesh_terms: D002241:Carbohydrates / Q000737:chemistry; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry*; D057930:Click Chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D002257:Carbonic Anhydrase Inhibitors; D013438:Sulfhydryl Compounds; D013449:Sulfonamides