title: Meta-analysis: accuracy of 18FDG PET-CT for distant metastasis staging in lung cancer patients.
abstract: BACKGROUND
  We undertook a meta-analysis to evaluate the accuracy of (18)FDG PET-CT for diagnosis of distant metastases in lung cancer patients.
  
  
  METHODS
  Studies about (18)FDG PET-CT for diagnosis of distant metastases in patients with lung cancer were systematically searched in the MEDLINE and EMBASE databases. We calculated sensitivities, specificities, positive likelihood ratios and negative likelihood ratios, and constructed summary receiver operating characteristic curves using bivariate regression models for (18)FDG PET-CT.
  
  
  RESULTS
  Across 9 studies (780 patients), the sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of (18)FDG PET-CT were 0.93 (95% confidence interval [CI] = 0.88-0.96), 0.96 (95% CI = 0.95-0.96), 28.4 (95% CI = 14.0-57.5), and 0.08 (95% CI = 0.02-0.37), respectively. Overall weighted area under the curve was 0.98 (95% CI = 0.96-0.99).
  
  
  CONCLUSIONS
  (18)FDG PET-CT has excellent diagnostic performance for diagnosis of distant metastases in patients with lung cancer.
authors.affiliation: Department of Oncology, The No. 456 Hospital of People's Liberation Army, Jinan 250031, PR China.
authors.forename: Junkai
authors.initials: J
authors.lastname: Li
authors.forename: Wen
authors.initials: W
authors.lastname: Xu
authors.forename: Fanjun
authors.initials: F
authors.lastname: Kong
authors.forename: Xueling
authors.initials: X
authors.lastname: Sun
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zuo
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification / Q000473:pathology*; D015201:Meta-Analysis as Topic; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D011379:Prognosis; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: (18)FDG PET-CT; Distant metastases; Lung cancer; Meta-analysis