title: A squaraine-based red emission off-on chemosensor for biothiols and its application in living cells imaging.
abstract: A new probe based on the squaraine skeleton with a 2,4-dinitrobenzenesulfonyl unit is reported as a fluorescent probe for biothiol. It shows turn-on properties with red emission towards biothiols in acetonitrile-PBS buffer (1 : 9, v/v) solution, and its properties of rapid response, high selectivity and high sensitivity make it a potential probe with real applications. Moreover, the in vitro assays show that the probe can be used in fluorescence imaging for the detection of intracellular biothiol levels.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Material Science, Soochow University, 199 Ren'Ai Road, Suzhou 215123, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Liu
authors.forename: Ru
authors.initials: R
authors.lastname: Sun
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Ge
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.forename: Jian-Mei
authors.initials: JM
authors.lastname: Lu
mesh_terms: D045744:Cell Line, Tumor; D003503:Cyclobutanes / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D018613:Microscopy, Confocal; D057054:Molecular Imaging; D010636:Phenols / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013438:Sulfhydryl Compounds / Q000032:analysis*
chemical_list: D003503:Cyclobutanes; D005456:Fluorescent Dyes; D010636:Phenols; D013438:Sulfhydryl Compounds; C480596:squaraine