title: Case report: profound hypotension after anesthetic induction with propofol in patients treated with rifampin.
abstract: Rifampin is commonly used for the treatment of tuberculosis and staphylococcal infections, as well as for prevention of infection in cardiac valve and bone surgeries. We report a case of profound hypotension after anesthesia induction with propofol in a patient who was treated with two 600 mg doses of rifampin for prophylaxis of infection before surgery. In a retrospective case-control study of 75 patients, we confirmed this potentially serious drug-drug interaction. After rifampin, there was a significant and prolonged arterial blood pressure reduction when patients received propofol, but not thiopental.
authors.affiliation: Department of Anesthesia and Critical Care, Massachusetts General Hospital, GRJ-4-416, 55 Fruit St., Boston, MA 02114-2696, USA.
authors.forename: Hooman
authors.initials: H
authors.lastname: Mirzakhani
authors.forename: Ala
authors.initials: A
authors.lastname: Nozari
authors.forename: Jesse M
authors.initials: JM
authors.lastname: Ehrenfeld
authors.forename: Robert
authors.initials: R
authors.lastname: Peterfreund
authors.forename: Michele
authors.initials: M
authors.lastname: Szabo
authors.forename: John L
authors.initials: JL
authors.lastname: Walsh
authors.forename: Yandong
authors.initials: Y
authors.lastname: Jiang
authors.forename: Warren
authors.initials: W
authors.lastname: Sandberg
authors.forename: Carl
authors.initials: C
authors.lastname: Rosow
authors.forename: Jingping
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D016022:Case-Control Studies; D004347:Drug Interactions / Q000502:physiology; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects*; D012189:Retrospective Studies; D012293:Rifampin / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D000904:Antibiotics, Antitubercular; D012293:Rifampin; D015742:Propofol