title: Helicobacter pyloriand Gastric Inflammation: Role of MUC1 Mucin.
abstract: More than half of the world's population is infected withHelicobacter pylori, which is strongly linked to the development of chronic gastric inflammation (gastritis), peptic ulcer disease, and stomach cancer. However, for unknown reasons, the vast majority of infected individuals are asymptomatic beyond histologic inflammation. This review article will summarize current knowledge on the molecular mechanisms ofH. pyloricolonization of the gastric mucosa, with a particular focus on the biochemistry of MUC1 mucin in the host response to bacterial infection.
authors.affiliation: Division of Pulmonology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.
authors.forename: Erik P
authors.initials: EP
authors.lastname: Lillehoj
authors.forename: Wei
authors.initials: W
authors.lastname: Guang
authors.forename: Hua
authors.initials: H
authors.lastname: Ding
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Czinn
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Blanchard
keywords: Helicobacter pylori; MUC1 mucin; epithelium; stomach