title: Amide-transforming activity of Streptomyces: possible application to the formation of hydroxy amides and aminoalcohols.
abstract: To develop an efficient bioconversion process for amides, we screened our collection of Streptomyces strains, mostly obtained from soil, for effective transformers. Five strains, including the SY007 (NBRC 109343) and SY435 (NBRC 109344) of Streptomyces sp., exhibited marked conversion activities from the approximately 700 strains analyzed. These strains transformed diverse amide compounds such as N-acetyltetrahydroquinoline, N-benzoylpyrrolidine, and N-benzoylpiperidine into alcohols or N,O-acetals with high activity and regioselectivity. N,O-acetal was transformed into alcohol by serial tautomerization and reduction reactions. As such, Streptomyces spp. can potentially be used for the efficient preparation of hydroxy amides and aminoalcohols.
authors.affiliation: Life Science Research Center, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252-0880, Japan. shinya_yamada@takasago.com
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamada
authors.forename: Taka-Aki
authors.initials: TA
authors.lastname: Miyagawa
authors.forename: Ren
authors.initials: R
authors.lastname: Yamada
authors.forename: Hatsumi
authors.initials: H
authors.lastname: Shiratori-Takano
authors.forename: Noboru
authors.initials: N
authors.lastname: Sayo
authors.forename: Takao
authors.initials: T
authors.lastname: Saito
authors.forename: Hideaki
authors.initials: H
authors.lastname: Takano
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Beppu
authors.forename: Kenji
authors.initials: K
authors.lastname: Ueda
mesh_terms: D000577:Amides / Q000737:chemistry / Q000378:metabolism*; D000605:Amino Alcohols / Q000737:chemistry / Q000378:metabolism*; D001711:Biotransformation; D015394:Molecular Structure; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000577:Amides; D000605:Amino Alcohols