title: Preparation and characterization of OSA/CS core-shell microgel: in vitro drug release and degradation properties.
abstract: Cationic polymers have been widely used as drug delivery systems. Herein, an oxidized sodium alginate/chitosan (OSA/CS) core-shell microgel was prepared via water-in-oil emulsion method. Morphological properties of the resulting microgel were determined by transmission electron microscopy, hydrodynamic diameter of the microgel was characterized by dynamic light scattering. The objective of this work was to achieve the colon-specific delivery of an antiulcerative colitis drug using a fully nontoxic carrier. 5-aminosalicylic acid (5-ASA) was chosen as a model drug, which is rapidly absorbed before entering the colon, thus it is necessary to develop a colon-specific delivery system for it. The in vitro drug release profile was established in buffer solutions with 0.1 M HCl/NaCl (pH 1.2) and 0.1 M phosphate buffered saline (pH 7.4) at 37 °C. The results indicated that this OSA/CS core-shell microgel inhibited the release of 5-ASA in stomach to a certain extent and is degradable in physiological conditions. Due to the excellent biocompatible nature of CS and OSA, this core-shell microgel has good biocompatibility and may have potential applications in oral controlled drug delivery systems.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Chunmei
authors.initials: C
authors.lastname: Gao
authors.forename: Mingzhu
authors.initials: M
authors.lastname: Liu
authors.forename: Shaoyu
authors.initials: S
authors.lastname: L
authors.forename: Chuanming
authors.initials: C
authors.lastname: Yu
authors.forename: Sheng
authors.initials: S
authors.lastname: Ma
authors.forename: Junyan
authors.initials: J
authors.lastname: Wang
authors.forename: Guijia
authors.initials: G
authors.lastname: Cui
mesh_terms: D020341:Absorbable Implants; D000327:Adsorption; D000464:Alginates / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D005782:Gels / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics*; D020723:Glucuronic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D006603:Hexuronic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D008422:Materials Testing; D019804:Mesalamine / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008954:Models, Biological; D054118:Nanospheres / Q000737:chemistry; D010084:Oxidation-Reduction; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000464:Alginates; D004337:Drug Carriers; D005782:Gels; D006603:Hexuronic Acids; D011108:Polymers; D019804:Mesalamine; D020723:Glucuronic Acid; D048271:Chitosan