title: [Significance of high sensitivity C-reactive protein level for predicting risk of nonalcoholic fatty liver in type 2 diabetes mellitus patients].
abstract: OBJECTIVE
  To investigate the significance of high sensitivity C-reactive protein (hsCRP) levels in serum for detecting type 2 diabetes mellitus (T2DM) patients at risk of developing nonalcoholic fatty liver (NAFLD).
  
  
  METHODS
  Individuals with T2DM (n = 9489) were recruited from the Kailuan Company between 2006 and 2007 for the first phase of this community-based prospective cohort study. For the second phase of the study, the original cohort was recruited for follow-up (at two years from each subject's original enrollment date (baseline)). The total followed-up subjects (n = 2802; 2344 males, 458 females, 22-88 years old) were categorized into quartiles according to baseline measurements of serum hsCRP levels (less than or equal to 0.30, > 0.30-0.60, > 0.60-1.92 and > 1.92 mg/L) and used to determine the relationship between change in incidence rates of NAFLD and predictive value of baseline serum hsCRP levels by logistic regression analysis.
  
  
  RESULTS
  Twenty-nine percent (n = 813) of the followed-up subjects developed NAFLD. The incidence (%) of NAFLD at the two-year follow-up had increased in conjunction with the level of serum hsCRP detected at baseline (quartile 1: 22.5%, 2: 27.3%, 3: 32.1%, and 4: 34.3%; all, P less than 0.01). It was found that the subjects in the highest quartile had an increased risk of NAFLD (odds ratio (OR) = 1.80, 95% confidence interval (CI): 1.42-2.28, P less than 0.01), as compared with those in the lowest quartile. Moreover, when the regression model was adjusted for baseline factors of age, sex, triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting serum glucose, and body mass index, the risk of NAFLD remained significantly higher for the highest quartile (vs. the lowest quartile; OR = 1.49, 95% CI: 1.16-1.91, P less than 0.01).
  
  
  CONCLUSIONS
  Serum hsCRP levels may be predictive of development of NAFLD in individuals with type 2 diabetes mellitus. The risk of NAFLD increases in parallel with increasing levels of serum hsCRP.
authors.affiliation: Department of Gastroenterology, Affiliated Kailuan Hospital of Hebei United University, Tangshan 063000, China.
authors.forename: Xiao-Zhong
authors.initials: XZ
authors.lastname: Jiang
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Wang
authors.forename: Shou-Ling
authors.initials: SL
authors.lastname: Wu
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Wang
authors.forename: He-Li
authors.initials: HL
authors.lastname: Duan
authors.forename: Guang-Jian
authors.initials: GJ
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein