title: Tramadol hydrochloride.
abstract: A profile of the analgesic tramadol hydrochloride ((1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride) is provided in this chapter and includes a summary of the physical characteristics known for this drug substance (e.g., UV/vis, IR, NMR, and mass spectra). Details regarding the stability of tramadol hydrochloride in the solid state and solution-phase are presented and methods of analysis (compendial and literature) are summarized. Furthermore, an account of biological properties and a description of the chemical synthesis of tramadol hydrochloride are given.
authors.affiliation: Apotex Inc., Toronto, Ontario, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Smyj
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Wang
authors.forename: Feixue
authors.initials: F
authors.lastname: Han
mesh_terms: D000701:Analgesics, Opioid / Q000032:analysis*; D000818:Animals; D004355:Drug Stability; D006801:Humans; D012995:Solubility; D014147:Tramadol / Q000032:analysis* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol