title: The ability of endotoxin adsorption during a longer duration of direct hemoperfusion with a polymyxin B-immobilized fiber column in patients with septic shock.
abstract: The patients' hemodynamic conditions of septic shock due to intra-abdominal infection were improved by the longer duration of direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX), reducing plasma endotoxins measured by the novel endotoxin detection method, named endotoxin scattering photometry (ESP) method; however, turbidimetric method could not detect endotoxins. We also observed the reduction in the endotoxin after passing through column by ESP method even after the longer duration of PMX. ESP method may more sensitively detect endotoxins than the ordinary turbidimetric method. Moreover, we demonstrated the ability of endotoxin adsorption in spite of the longer duration of PMX.
authors.affiliation: Department of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan. Electronic address: tomoharu@belle.shiga-med.ac.jp.
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Shimizu
authors.forename: Toru
authors.initials: T
authors.lastname: Obata
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Sonoda
authors.forename: Hiroya
authors.initials: H
authors.lastname: Akabori
authors.forename: Takahisa
authors.initials: T
authors.lastname: Tabata
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Eguchi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Endo
authors.forename: Tohru
authors.initials: T
authors.lastname: Tani
mesh_terms: D000327:Adsorption; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004731:Endotoxins / Q000097:blood* / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011112:Polymyxin B / Q000008:administration & dosage* / Q000009:adverse effects; D012772:Shock, Septic / Q000097:blood / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D004731:Endotoxins; D011112:Polymyxin B
keywords: Endotoxin; Infection; Polymyxin B-immobilized fiber; Septic shock