title: Post-retrieval late process contributes to persistence of reactivated fear memory.
abstract: Several studies have demonstrated the mechanisms involved in memory persistence after learning. However, little is known about memory persistence after retrieval. In this study, a protein synthesis inhibitor, anisomycin, was infused into the basolateral amygdala of mice 9.5 h after retrieval of contextual conditioned fear. Anisomycin attenuated fear memory after 7 d, but not after 2 d. In contrast, infusion of anisomycin 5- or 24-h post-retrieval was ineffective. These findings indicate that anisomycin attenuates the persistence of reactivated fear memory in a time-dependent manner. We propose that late protein synthesis is required for memory persistence after retrieval.
authors.affiliation: Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakayama
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Norio
authors.initials: N
authors.lastname: Matsuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nomura
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D003213:Conditioning, Psychological; D005239:Fear; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology
chemical_list: D011500:Protein Synthesis Inhibitors; D000841:Anisomycin