title: A solitary fibrous tumor with giant cells in the lacrimal gland: a case study.
abstract: Orbital solitary fibrous tumor (SFT) has recently been proposed as the encompassing terminology for hemangiopericytoma, giant cell angiofibroma (GCAF), and fibrous histiocytoma of the orbit. The lacrimal gland is a very rare location for both SFT and GCAF. A 39-year-old man presented with a painless left upper eyelid mass. An orbital computed tomography scan identified a 1.1 cm-sized well-defined nodule located in the left lacrimal gland. He underwent a mass excision. Histopathologic examination showed a proliferation of relatively uniform spindle cells with a patternless or focally storiform pattern. Dilated vessels were prominent, but angiectoid spaces lined with giant cells were absent. Floret-type giant cells were mostly scattered in the periphery. The tumor was immunoreactive for CD34 and CD99, but negative for smooth muscle actin and S-100 protein. This is the first Korean case of SFT of the lacrimal gland with overlapping features of GCAF, suggesting a close relationship between the two entities.
authors.affiliation: Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Da Hye
authors.initials: DH
authors.lastname: Son
authors.forename: Su Hyun
authors.initials: SH
authors.lastname: Yoo
authors.forename: Ho-Seok
authors.initials: HS
authors.lastname: Sa
authors.forename: Kyung-Ja
authors.initials: KJ
authors.lastname: Cho
keywords: Giant cells; Lacrimal apparatus; Orbit; Solitary fibrous tumors