title: New insights into the machinery of blood digestion by ticks.
abstract: Blood-protein digestion is a key physiological process providing essential nutrients for ticks and is a prerequisite for the transmission of tick-borne pathogens. Recently, substantial progress has been made in determining the proteolytic machinery in tick gut tissue, which is based on a dynamic multienzyme network capable of processing a vast amount of host blood. In this article we summarize our current knowledge of the molecular mechanisms of tick hematophagy and their similarities to those of Platyhelminthes, nematodes, and Plasmodium. Future research perspectives, including the potential for rational control of ticks and transmitted diseases, are also discussed.
authors.affiliation: Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, České Budějovice, CZ 370 05, Czech Republic.
authors.forename: Daniel
authors.initials: D
authors.lastname: Sojka
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Franta
authors.forename: Martin
authors.initials: M
authors.lastname: Horn
authors.forename: Conor R
authors.initials: CR
authors.lastname: Caffrey
authors.forename: Michael
authors.initials: M
authors.lastname: Mareš
authors.forename: Petr
authors.initials: P
authors.lastname: Kopáček
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D004063:Digestion / Q000502:physiology; D041981:Gastrointestinal Tract / Q000201:enzymology; D013987:Ticks / Q000502:physiology*
chemical_list: D001798:Blood Proteins