title: Changing risk behaviours and the HIV epidemic: a mathematical analysis in the context of treatment as prevention.
abstract: BACKGROUND
  Expanding access to highly active antiretroviral therapy (HAART) has become an important approach to HIV prevention in recent years. Previous studies suggest that concomitant changes in risk behaviours may either help or hinder programs that use a Treatment as Prevention strategy.
  
  
  METHODS
  We consider HIV-related risk behaviour as a social contagion in a deterministic compartmental model, which treats risk behaviour and HIV infection as linked processes, where acquiring risk behaviour is a prerequisite for contracting HIV. The equilibrium behaviour of the model is analysed to determine epidemic outcomes under conditions of expanding HAART coverage along with risk behaviours that change with HAART coverage. We determined the potential impact of changes in risk behaviour on the outcomes of Treatment as Prevention strategies. Model results show that HIV incidence and prevalence decline only above threshold levels of HAART coverage, which depends strongly on risk behaviour parameter values. Expanding HAART coverage with simultaneous reduction in risk behaviour act synergistically to accelerate the drop in HIV incidence and prevalence. Above the thresholds, additional HAART coverage is always sufficient to reverse the impact of HAART optimism on incidence and prevalence. Applying the model to an HIV epidemic in Vancouver, Canada, showed no evidence of HAART optimism in that setting.
  
  
  CONCLUSIONS
  Our results suggest that Treatment as Prevention has significant potential for controlling the HIV epidemic once HAART coverage reaches a threshold. Furthermore, expanding HAART coverage combined with interventions targeting risk behaviours amplify the preventive impact, potentially driving the HIV epidemic to elimination.
authors.affiliation: The IRMACS Centre, Simon Fraser University, Burnaby, British Columbia, Canada.
authors.forename: Bojan
authors.initials: B
authors.lastname: Ramadanovic
authors.forename: Krisztina
authors.initials: K
authors.lastname: Vasarhelyi
authors.forename: Ali
authors.initials: A
authors.lastname: Nadaf
authors.forename: Ralf W
authors.initials: RW
authors.lastname: Wittenberg
authors.forename: Julio S G
authors.initials: JS
authors.lastname: Montaner
authors.forename: Evan
authors.initials: E
authors.lastname: Wood
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Rutherford
mesh_terms: D000465:Algorithms; D023241:Antiretroviral Therapy, Highly Active; D001955:British Columbia / Q000453:epidemiology; D058872:Epidemics; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control; D015994:Incidence; D015233:Models, Statistical; D015995:Prevalence; D012309:Risk-Taking