title: Rodent models for investigating the dysregulation of immune responses in type 1 diabetes.
abstract: Type 1 diabetes (T1D) is an autoimmune disease mediated by T cells that selectively destroy the insulin-producing β cells. Previous reports based on epidemiological and animal studies have demonstrated that both genetic factors and environmental parameters can either promote or attenuate the progression of autoimmunity. In recent decades, several inbred rodent strains that spontaneously develop diabetes have been applied to the investigation of the pathogenesis of T1D. Because the genetic manipulation of mice is well developed (transgenic, knockout, and conditional knockout/transgenic), most studies are performed using the nonobese diabetic (NOD) mouse model. This paper will focus on the use of genetically manipulated NOD mice to explore the pathogenesis of T1D and to develop potential therapeutic approaches.
authors.affiliation: Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, R8324, 161, Section 6, MinChuan East Road, Neihu, Taipei 114, Taiwan.
authors.forename: Feng-Cheng
authors.initials: FC
authors.lastname: Chou
authors.forename: Heng-Yi
authors.initials: HY
authors.lastname: Chen
authors.forename: Shyi-Jou
authors.initials: SJ
authors.lastname: Chen
authors.forename: Mei-Cho
authors.initials: MC
authors.lastname: Fang
authors.forename: Huey-Kang
authors.initials: HK
authors.lastname: Sytwu