title: Nearby Construction Impedes the Progression to Overt Autoimmune Diabetes in NOD Mice.
abstract: Construction nearby animal houses has sporadically been reported to affect various aspects of animal health. Most of the reports have focussed on the impact on stress hormone levels and the hypersensitivity of animals relative to humans. There has also been an anecdotal report on the impact of construction on autoimmune diabetes in NOD mice. Here, we describe that nearby construction significantly impedes the progression to overt diabetes in female NOD mice offspring. We demonstrate that this was not due to a genetic drift or to particularities associated with our specific mouse colony. Interestingly, although the glycemia levels remained low in mice born from mothers subject to construction stress during gestation, we detected an active autoimmune reaction towards pancreatic islet cells, as measured by both the degree of insulitis and the presence of insulin autoantibody levels in the serum. These results suggest that the external stress imposed during embryonic development does not prevent but significantly delays the autoimmune process. Together, our findings emphasize the impact of surrounding factors during in vivo studies and are in agreement with the hypothesis that both environmental and genetic cues contribute to autoimmune diabetes development.
authors.affiliation: Maisonneuve-Rosemont Hospital Research Center, Montréal, QC, Canada H1T 2M4 ; Department of Microbiology and Immunology, University of Montreal, Montréal, QC, Canada H3C 3J7.
authors.forename: Erin E
authors.initials: EE
authors.lastname: Hillhouse
authors.forename: Roxanne
authors.initials: R
authors.lastname: Collin
authors.forename: Geneviève
authors.initials: G
authors.lastname: Chabot-Roy
authors.forename: Marie-Josée
authors.initials: MJ
authors.lastname: Guyon
authors.forename: Nathalie
authors.initials: N
authors.lastname: Tessier
authors.forename: Maryse
authors.initials: M
authors.lastname: Boulay
authors.forename: Patricia
authors.initials: P
authors.lastname: Liscourt
authors.forename: Sylvie
authors.initials: S
authors.lastname: Lesage