title: Early Effect of Single-dose Sitagliptin Administration on Gastric Emptying: Crossover Study Using the (13)C Breath Test.
abstract: OBJECTIVE
  The gastrointestinal motility effects of endogenous incretin hormones enhanced by dipeptidyl peptidase-IV (DPP-IV) inhibitors have not yet been sufficiently investigated. The aim of this study was to determine whether single pre-prandial sitagliptin, the DPP-IV inhibitor, administration might have an effect on the rate of liquid gastric emptying using the (13)C-acetic acid breath test.
  
  
  METHODS
  Ten healthy male volunteers participated in this randomized, two-way crossover study. The subjects fasted for overnight and were randomly assigned to receive 50 mg sitagliptin 2 hours before ingestion of the liquid test meal (200 kcal per 200 mL, containing 100 mg (13)C-acetate) or the test meal alone. Under both conditions, breath samples were collected for 150 minutes following the meal. Liquid gastric emptying was estimated by the values of the following parameters: the time required for 50% emptying of the labeled meal (T1/2), the analog to the scintigraphy lag time for 10% emptying of the labeled meal (Tlag), the gastric emptying coefficient and the regression-estimated constants (β and κ), calculated by using the (13)CO2 breath excretion curve using the conventional formulae. The parameters between the 2 test conditions were compared statistically.
  
  
  RESULTS
  No significant differences in the calculated parameters, including T1/2, Tlag, gastric emptying coefficient or β and κ, were observed between the 2 test conditions.
  
  
  CONCLUSIONS
  The present study revealed that single-dose sitagliptin intake had no significant influence on the rate of liquid gastric emptying in asymptomatic volunteers.
authors.affiliation: Gastroenterology Division, Yokohama City University Hospital, Yokohama, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nonaka
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sekino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iida
authors.forename: Eiji
authors.initials: E
authors.lastname: Yamada
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ohkubo
authors.forename: Eiji
authors.initials: E
authors.lastname: Sakai
authors.forename: Takuma
authors.initials: T
authors.lastname: Higurashi
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Hosono
authors.forename: Hiroki
authors.initials: H
authors.lastname: Endo
authors.forename: Tomoko
authors.initials: T
authors.lastname: Koide
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Koji
authors.initials: K
authors.lastname: Fujita
authors.forename: Masato
authors.initials: M
authors.lastname: Yoneda
authors.forename: Ayumu
authors.initials: A
authors.lastname: Goto
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kusakabe
authors.forename: Noritoshi
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Eiji
authors.initials: E
authors.lastname: Gotoh
authors.forename: Shin
authors.initials: S
authors.lastname: Maeda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
authors.forename: Chihiro
authors.initials: C
authors.lastname: Nosaka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Inamori
keywords: Breath tests; Gastric emptying; Sitagliptin