title: Dibenzotetraaza[14]annulene-adenine conjugate recognizes complementary poly dT among ss-DNA/ss-RNA sequences.
abstract: Among three novel DBTAA derivatives only the DBTAA-propyl-adenine conjugate showed recognition of the consecutive oligo dT sequence by increased affinity and specific induced chirooptical response in comparison to other single stranded RNA and DNA; whereby of particular importance is the up until now unique efficient differentiation between dT and rU. At variance, its close analogue DBTAA-hexyl-adenine did not reveal any selectivity between ss-DNA/RNA pointing out the important role of steric factors (linker length); moreover non-selectivity of the reference compound (, lacking adenine) stressed the importance of adenine interactions in the selectivity.
authors.affiliation: Division of Organic Chemistry and Biochemistry, Division of Physical Chemistry, NMR Centre, Ruđer Bošković Institute, Bijenička cesta 54, PO Box 180, HR-10002 Zagreb, Croatia.
authors.forename: Marijana
authors.initials: M
authors.lastname: Radić Stojković
authors.forename: Marko
authors.initials: M
authors.lastname: Škugor
authors.forename: Sanja
authors.initials: S
authors.lastname: Tomić
authors.forename: Marina
authors.initials: M
authors.lastname: Grabar
authors.forename: Vilko
authors.initials: V
authors.lastname: Smrečki
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Dudek
authors.forename: Jarosław
authors.initials: J
authors.lastname: Grolik
authors.forename: Julita
authors.initials: J
authors.lastname: Eilmes
authors.forename: Ivo
authors.initials: I
authors.lastname: Piantanida
mesh_terms: D000225:Adenine / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D011071:Poly T / Q000737:chemistry*; D011726:Pyridinium Compounds / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
chemical_list: D004277:DNA, Single-Stranded; D006575:Heterocyclic Compounds, 3-Ring; D011726:Pyridinium Compounds; D011071:Poly T; D012313:RNA; D000225:Adenine