title: [Clinical and serological analyses of 70 erythrocyte allo-antibodies to MNS blood group system].
abstract: OBJECTIVE
  To explore the occurrence and clinical significance of erythrocyte allo-antibodies to MNS blood group system among hospitalized patients in China.
  
  
  METHODS
  The specificity and clinical features of erythrocyte allo-antibodies detected from August 2009 to July 2012 were retrospectively analyzed.
  
  
  RESULTS
  A total of 187 erythrocyte allo-antibodies were detected from 66 042 hospitalized patients (0.28%) among which 70 (37.4%) were specific to MNS blood group system. Antibody frequencies were as follows: anti-M, 18.2%; anti-Mi(a), 18.2%; anti-S, 1.1%. Anti-Mi(a) was more frequent among transfused patients (16/34 vs 5/34, P = 0.004), and tended to be accompanied by other allo-antibodies.
  
  
  CONCLUSIONS
  Antibodies to MNS blood group system are second only to Rh system as the most common erythrocyte allo-antibodies in China. And anti-Mi(a) is an important transfusion-related allo-antibody among the patients of southern ancestry.
authors.affiliation: Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Bo-ting
authors.initials: BT
authors.lastname: Wu
authors.forename: Ding-gen
authors.initials: DG
authors.lastname: Yao
authors.forename: Rui-ming
authors.initials: RM
authors.lastname: Rong
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001787:Blood Group Incompatibility / Q000276:immunology; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000097:blood / Q000276:immunology*; D008951:MNSs Blood-Group System / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012204:Rh-Hr Blood-Group System / Q000276:immunology; D065227:Transfusion Reaction
chemical_list: D007518:Isoantibodies; D008951:MNSs Blood-Group System; D012204:Rh-Hr Blood-Group System