title: GPER-1 expression decreases during breast cancer tumorigenesis.
abstract: GPER-1 protein expression was immunohistochemically examined in 164 primary breast cancer specimens and their matched normal breast epithelium. GPER-1 down-regulation correlated significantly with increased histological grading (p = .015), lymph node metastases (p = .032), and negative estrogen receptor status (p = .018). The decrease of GPER-1 expression in breast cancer tissue, relative to normal tissue, was associated with poor overall survival (p = .043) and disease-free survival (p = .037) and remained a significant unfavorable factor in multivariate analysis for DFS (HR = 1.569; 95% CI, 1.024-2.797; p = .041) and OS (HR = 2.082; 95% CI, 1.248-4.773; p = .039). Thus aberrant GPER-1 expression seems to be an important factor in breast cancer progression.
authors.affiliation: Department of Obstetrics and Gynecology, Otto-von-Guericke University, Magdeburg, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Ignatov
authors.forename: Christine
authors.initials: C
authors.lastname: Weißenborn
authors.forename: Angela
authors.initials: A
authors.lastname: Poehlmann
authors.forename: Antje
authors.initials: A
authors.lastname: Lemke
authors.forename: Andrzej
authors.initials: A
authors.lastname: Semczuk
authors.forename: Albert
authors.initials: A
authors.lastname: Roessner
authors.forename: Serban Dan
authors.initials: SD
authors.lastname: Costa
authors.forename: Thomas
authors.initials: T
authors.lastname: Kalinski
authors.forename: Atanas
authors.initials: A
authors.lastname: Ignatov
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D018572:Disease-Free Survival; D005260:Female; D015870:Gene Expression; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D011960:Receptors, Estrogen / Q000235:genetics* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors
chemical_list: C109584:GPER1 protein, human; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled