title: Differential expression of matrix metalloproteinase-13 in mucinous and nonmucinous colorectal carcinomas.
abstract: Colorectal carcinoma (CRC) is a major health problem all over the world. Mucinous CRCs are known to have a peculiar behavior and genetic derangements. This study aimed to investigate matrix metalloproteinase (MMP)-13 expression in mucinous and nonmucinous CRCs. We studied tumor tissue specimens from 150 patients with mucinous and nonmucinous CRC who underwent radical surgery from January 2007 to January 2012. High-density manual tissue microarrays were constructed using a modified mechanical pencil tip technique, and paraffin sections were submitted for immunohistochemistry using MMP-13. Statistical analysis was performed for clinical and pathological data of all studied cases together with MMP-13 expression in mucinous and nonmucinous groups. Mucinous carcinoma was significantly associated with young age, more depth of invasion, lymph node metastasis, and less peritumoral and intratumoral neutrophils. Nonmucinous carcinomas showed higher MMP-13 expression compared with mucinous carcinomas. Despite the negative or low expression of MMP-13, mucinous carcinomas had more depth of invasion and more frequency of lymph node metastasis than did nonmucinous carcinomas.
authors.affiliation: Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
authors.forename: Abd Al-Rahman Mohammad
authors.initials: AA
authors.lastname: Foda
authors.forename: Amira K
authors.initials: AK
authors.lastname: El-Hawary
authors.forename: Azza
authors.initials: A
authors.lastname: Abdel-Aziz
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D053509:Matrix Metalloproteinase 13 / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D053509:Matrix Metalloproteinase 13
keywords: Carcinoma; Colorectal; MMP-13; Microarray; Mucinous; Nonmucinous