title: The multiple activities of BMPs during spinal cord development.
abstract: Bone morphogenetic proteins (BMPs) are one of the main classes of multi-faceted secreted factors that drive vertebrate development. A growing body of evidence indicates that BMPs contribute to the formation of the central nervous system throughout its development, from the initial shaping of the neural primordium to the generation and maturation of the different cell types that form the functional adult nervous tissue. In this review, we focus on the multiple activities of BMPs during spinal cord development, paying particular attention to recent results that highlight the complexity of BMP signaling during this process. These findings emphasize the unique capacity of these signals to mediate various functions in the same tissue throughout development, recruiting diverse effectors and strategies to instruct their target cells.
authors.affiliation: Instituto de Biología Molecular de Barcelona, CSIC, Parc Científic de Barcelona, C/Baldiri i Reixac 10-15, 08028, Barcelona, Spain, gldbmc@ibmb.csic.es.
authors.forename: Gwenvael
authors.initials: G
authors.lastname: Le Dréau
authors.forename: Elisa
authors.initials: E
authors.lastname: Martí
mesh_terms: D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D002454:Cell Differentiation; D002490:Central Nervous System / Q000378:metabolism; D006801:Humans; D009474:Neurons / Q000378:metabolism; D015398:Signal Transduction; D013116:Spinal Cord / Q000254:growth & development / Q000378:metabolism*
chemical_list: D019485:Bone Morphogenetic Proteins