title: Platinum(II) complexes containing aminophosphonate esters: Synthesis, characterization, cytotoxicity and action mechanism.
abstract: New platinum(II) complexes containing aminophosphonate ester were synthesized and fully characterized, which were found to possess better solubility in both organic solvents and water than cisplatin. These platinum(II) complexes exhibited considerable cytotoxicity against tumor cells MG-63, SK-OV-3, HepG2, BEL-7404 and low cytotoxicity to normal human liver cells HL-7702. Their antitumor activities were achieved through the induction of cell apoptosis and the cell cycle arrest at G1 phase. The electrophoretic mobility studies and CD spectral analysis revealed that the binding mode of complex 6 to DNA might be different from that of cisplatin.
authors.affiliation: School of Chemistry of Nankai University, Tianjin 300071, PR China.
authors.forename: Ke-Bin
authors.initials: KB
authors.lastname: Huang
authors.forename: Zhen-Feng
authors.initials: ZF
authors.lastname: Chen
authors.forename: Yan-Cheng
authors.initials: YC
authors.lastname: Liu
authors.forename: Zhu-Quan
authors.initials: ZQ
authors.lastname: Li
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Wei
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Xie
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004952:Esters / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D063065:Organophosphonates / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004952:Esters; D009942:Organometallic Compounds; D063065:Organophosphonates; D010984:Platinum