title: Prelog and anti-Prelog stereoselectivity of two ketoreductases from Candida glabrata.
abstract: Two ketoreductases from Candida glabrata were used for the asymmetric reduction of prochiral substituted acetophenones displayed different enantiopreference toward para-, meta-substituted and ortho-halogen substituted acetophenones with excellent enantioselectivity. Homology modeling and docking analysis were in conformity with this interested enantiopreference obtained from experimental tests. The reduction of a series of other substituted aryl ketones was also investigated using the two ketoreductases.
authors.affiliation: School of Life Sciences & Biopharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
authors.forename: Bin
authors.initials: B
authors.lastname: Qin
authors.forename: Mao
authors.initials: M
authors.lastname: Mu
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Xian
authors.initials: X
authors.lastname: Jia
authors.forename: Song
authors.initials: S
authors.lastname: You
mesh_terms: D000098:Acetophenones / Q000737:chemistry / Q000378:metabolism*; D041221:Candida glabrata / Q000201:enzymology*; D062105:Molecular Docking Simulation; D010088:Oxidoreductases / Q000378:metabolism*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000098:Acetophenones; D010088:Oxidoreductases