title: Total and high molecular weight adiponectin levels and risk of cardiovascular disease in individuals with high blood glucose levels.
abstract: OBJECTIVE
  The association of adiponectin levels with cardiovascular disease (CVD) may vary by age and health condition. It is unknown whether adiponectin predicts CVD events among individuals with high blood glucose levels.
  
  
  METHODS
  We conducted a nested case-control study among 15,566 men and women aged 40-85 years from four communities, who were free of CVD at baseline. During 192,181 person-years of follow-up, 117 individuals subsequently developed coronary heart disease or ischemic stroke and had high plasma glucose concentrations (fasting/nonfasting ≥ 5.6/7.2 mmol/L or treated) at baseline. Controls were randomly selected at a 2:1 ratio and matched for sex, age, blood glucose, year of survey, fasting conditions, and community (n = 234). Baseline total and high molecular weight (HMW) adiponectin and their ratio were examined for total subjects and the association with CVD was compared between ages of 40-69 and 70-85 years.
  
  
  RESULTS
  After adjustment for matched variables and traditional risk factors, total and HMW adiponectin and their ratio were not associated with overall risk of CVD. However, significant interactions of the associations between the age groups were found. The highest quartile for HMW adiponectin and HMW/total adiponectin ratio decreased risk of CVD compared with the lowest quartile among middle-aged individuals (multivariable-adjusted odds ratio = 0.33 [95%CI, 0.13-0.83] and 0.47 [0.22-0.98], respectively), while this association was not seen among the elderly.
  
  
  CONCLUSIONS
  High HMW adiponectin levels may decrease the risk of CVD in middle-aged adults with high blood glucose.
authors.affiliation: Department of Basic Nursing and Health Science, Ehime University Graduate School of Medicine, Toon, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Saito
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yamagishi
authors.forename: Choy-Lye
authors.initials: CL
authors.lastname: Chei
authors.forename: Renzhe
authors.initials: R
authors.lastname: Cui
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ohira
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kitamura
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kiyama
authors.forename: Hironori
authors.initials: H
authors.lastname: Imano
authors.forename: Takeo
authors.initials: T
authors.lastname: Okada
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Kato
authors.forename: Shinichi
authors.initials: S
authors.lastname: Hitsumoto
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose