title: Exposure to low dose ionising radiation: molecular and clinical consequences.
abstract: This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HRS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect.
authors.affiliation: Urologic and Radiation Oncology, Applied Radiation Therapy Trinity and Prostate Molecular Oncology Research Group, Discipline of Radiation Therapy and Institute of Molecular Medicine, Trinity College Dublin, Ireland.
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Martin
authors.forename: Brian
authors.initials: B
authors.lastname: Marples
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Lynch
authors.forename: Donal
authors.initials: D
authors.lastname: Hollywood
authors.forename: Laure
authors.initials: L
authors.lastname: Marignol
mesh_terms: D002453:Cell Cycle / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy*; D011836:Radiation Tolerance; D011839:Radiation, Ionizing; D011878:Radiotherapy / Q000379:methods*
keywords: Cell cycle arrest; DNA damage; Hypersensitivity; Ionising radiation; Low dose