title: Vitamin D levels during and after resolution of ketoacidosis in children with new onset Type 1 diabetes.
abstract: OBJECTIVE
  To study the effect of ketoacidosis on measured 25-hydroxyvitamin D3 in children with new onset Type 1 diabetes.
  
  
  METHODS
  Measurement of pH and bicarbonate levels was carried out in children with newly diagnosed Type 1 diabetes at presentation with ketoacidosis. 25-hydroxyvitamin D3 estimation was carried out at presentation (timepoint 1) and 1 month later (timepoint 2). There was no significant difference in the mean (±sd) 25-hydroxyvitamin D3 levels [35.39 (±25.79) vs 39.63 (±48.03) nmol/L; P = 0.661) at the two timepoints in the study.
  
  
  RESULTS
  Correlation analysis revealed a positive correlation between bicarbonate levels and timepoint 1, i.e. the lower the bicarbonate levels, the lower were the timepoint 1 levels and vice versa (correlation coefficient 0.538, P = 0.001). Timepoint 2 levels also showed a positive correlation with serum bicarbonate levels with a correlation coefficient of 0.379 (P = 0.032). None of the variables other than bicarbonate,.(age, gender, BMI, pH or time), was found to have the predictive ability for timepoint1 levels. Similarly for predicting timepoint 2 levels, BMI was found to have independent predictive ability in addition to bicarbonate.
  
  
  CONCLUSIONS
  Severe ketoacidosis, as judged by bicarbonate but not pH, may transiently lower 25-hydroxyvitamin D3 levels in children with new onset Type 1 diabetes. Persistence of low 25-hydroxyvitamin D3 levels after resolution of ketoacidosis suggests a state of permanent vitamin D deficiency in our patient population.
authors.affiliation: Department of Paediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. drdevidayal@indiatimes.com
authors.lastname: Devidayal
authors.forename: M K
authors.initials: MK
authors.lastname: Singh
authors.forename: N
authors.initials: N
authors.lastname: Sachdeva
authors.forename: S
authors.initials: S
authors.lastname: Singhi
authors.forename: S V
authors.initials: SV
authors.lastname: Attri
authors.forename: M
authors.initials: M
authors.lastname: Jayashree
authors.forename: A K
authors.initials: AK
authors.lastname: Bhalla
mesh_terms: D001639:Bicarbonates / Q000097:blood; D015992:Body Mass Index; D002112:Calcifediol / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000175:diagnosis; D016883:Diabetic Ketoacidosis / Q000097:blood* / Q000628:therapy*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D008297:Male; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications
chemical_list: D001639:Bicarbonates; D002112:Calcifediol