title: [Schizophrenia: research perspectives].
abstract: Current data and perspectives for schizophrenia research were reviewed in this paper. Increased incidence of schizophrenia is correlated to perinatal environmental factors, recent immigration, urban life and cannabis. Determining endophenotypes seems to be a promising strategy in the field of molecular genetics. Side effects and efficacy of treatments for schizophrenia could, now, be better predicted by the use of pharmacogenetic studies. Functional neuroimaging studies have described hypoactivations of certain brain areas supporting the hypothesis of a dysfunction of inner speech during auditory and verbal hallucinations. Dopaminergic and glutamatergic systems are disturbed in schizophrenia. These data contribute to a better understanding of the disease and may help to decrease the stigma that surrounds schizophrenia.
authors.affiliation: Département de psychiatrie, université fédérale du Minas Gerais (UFMG), Belo Horizonte, Brésil. delavenne.heloise@gmail.com
authors.forename: Héloïse
authors.initials: H
authors.lastname: Delavenne
authors.forename: Frederico D
authors.initials: FD
authors.lastname: Garcia
authors.forename: Florence
authors.initials: F
authors.lastname: Thibaut
mesh_terms: D035843:Biomedical Research; D020022:Genetic Predisposition to Disease; D006801:Humans; D012559:Schizophrenia / Q000235:genetics