title: Dysfunctional co-expression network analysis of familial hypercholesterolemia.
abstract: Familial hypercholesterolemia (FH) is an inherited disorder of blood lipid metabolism characterized by high serum low-density lipoprotein cholesterol levels and premature coronary artery disease. In this study, we used a system biology approach to identify co-expressed gene pairs that were potentially involved in the progression of FH and constructed a conserved co-expression network using these genes. A total of 4232 co-expressed relationships were identified and we verified the significance by random permutation. FH patients showed differences in lipoprotein and cholesterol metabolism in circulating monocytes and lymphocytes compared to healthy controls. We hope our study could aid in understanding of FH and could provide the basis for FH biomarker identification.
authors.affiliation: Department of Cardiovascular Surgery, Affiliated Shanghai 1st People's Hospital, Shanghai Jiaotong University, Shanghai 210008, People's Republic of China.
authors.forename: Yizhou
authors.initials: Y
authors.lastname: Ye
authors.forename: Kefei
authors.initials: K
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Mingqiu
authors.initials: M
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Ruxing
authors.initials: R
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Zou
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
authors.forename: Liuyan
authors.initials: L
authors.lastname: Wei
authors.forename: Guoqing
authors.initials: G
authors.lastname: Jiao
authors.forename: Zhongxiang
authors.initials: Z
authors.lastname: Yuan
mesh_terms: D002784:Cholesterol / Q000097:blood; D015342:DNA Probes; D015870:Gene Expression; D053263:Gene Regulatory Networks; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics* / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood; D008214:Lymphocytes / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism
chemical_list: D015342:DNA Probes; D008074:Lipoproteins; D002784:Cholesterol
keywords: Co-expression network; Differentially expressed genes; Familial hypercholesterolemia