title: Serum HMGB1 as a diagnostic marker for malignant peritoneal mesothelioma.
abstract: BACKGROUND
  Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to cytoreductive surgery along with intraperitoneal chemotherapy. Therefore, early diagnosis of DMPM is very important. Some researchers have previously reported that high-mobility group box 1 (HMGB1) was correlated with pulmonary fibrosis. DMPM involves the malignant transformation of mesothelial cells, which originate from mesenchymal cells, similar to lung fibroblasts. Here, we investigated serum levels of HMGB1 in patients with MPM and compared them with those of a population that had been exposed to asbestos without developing MPM.
  
  
  METHODS
  The serum concentrations of HMGB1 were measured in 13 DMPM patients and 45 individuals with benign asbestos-related diseases.
  
  
  RESULTS
  We demonstrated that the patients with DMPM had significantly higher serum levels of HMGB1 compared with the population who had been exposed to asbestos but did not develop DMPM.
  
  
  CONCLUSIONS
  Our data suggest that serum HMGB1 concentration is a useful serum marker for DMPM.
authors.affiliation: Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan. ctabata@hyo-med.ac.jp
authors.forename: Chiharu
authors.initials: C
authors.lastname: Tabata
authors.forename: Shingo
authors.initials: S
authors.lastname: Kanemura
authors.forename: Rie
authors.initials: R
authors.lastname: Tabata
authors.forename: Eriko
authors.initials: E
authors.lastname: Masachika
authors.forename: Eisuke
authors.initials: E
authors.lastname: Shibata
authors.forename: Tai-Ichiro
authors.initials: T
authors.lastname: Otsuki
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Nishizaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakano
mesh_terms: D000368:Aged; D001194:Asbestos / Q000633:toxicity; D001195:Asbestosis / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D024243:HMGB1 Protein; D001194:Asbestos