title: Chemical constituents of Callicarpa nudiflora and their anti-platelet aggregation activity.
abstract: Two new triterpenoids, 2α,3α,19α,23-tetrahydroxyurs-12,20(30)-dien-28-oic acid (1) and 2α,3α,19α-trihydroxyurs-12-en-28-oic acid-28-O-β-D-xylopyranosyl (1→2)-β-D-glucopyranoside (2), and a new acylated flavone glycoside, luteolin 3'-O-(6″-E-caffeoyl)-β-D-glucopyranoside (3), together with three known compounds (4-6), were isolated from the leaves of Callicarpa nudiflora Hook. Their structures were elucidated on the basis of spectroscopic data and chemical methods. Anti-platelet aggregation activities of these compounds were evaluated in vitro. Compounds 1 and 2 showed inhibitory effects on ADP-induced platelet aggregation with EC50 values of 9.48 μM and 25.31 μM, respectively.
authors.affiliation: Pharmaceutical Department of Nanchang University, Nanchang 330006, PR China; Jiangxi Provincial Institute for Drug and Food Control, Nanchang 330029, PR China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Key Labotatory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, PR China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
authors.affiliation: Jiangxi Provincial Institute for Drug and Food Control, Nanchang 330029, PR China.
authors.forename: Huizheng
authors.initials: H
authors.lastname: Fu
authors.affiliation: Jiangxi Provincial Institute for Drug and Food Control, Nanchang 330029, PR China. Electronic address: emailluo@sohu.com.
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Luo
mesh_terms: D000818:Animals; D032408:Callicarpa / Q000737:chemistry*; D066298:In Vitro Techniques; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D010972:Platelet Activating Factor; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C000594163:2,3,19,23-tetrahydroxyurs-12,20(30)-dien-28-oic acid; C000594164:2,3,19-trihydroxyurs-12-en-28-oic acid-28-O-xylopyranosyl-(1-2)-glucopyranoside; D010936:Plant Extracts; D010972:Platelet Activating Factor; D012503:Saponins; D014315:Triterpenes
keywords: Anti-platelet aggregation; Callicarpa nudiflora Hook; Flavone glycoside; Triterpenoids