title: [Orthostatic response of blood pressure in patients with early Parkinson's disease].
abstract: OBJECTIVE
  To evaluate orthostatic blood pressure response in patients with early Parkinson's disease and mild to moderate disease treated at the National Institute of Neurology and Neurosurgery.
  
  
  METHODS
  A cross-sectional study with control group was carried out. Patients with Parkinson's disease with a disease duration of less than 5 years and mild to moderate severity along with healthy controls of the same age group were included. Those subjects with diabetes mellitus, hypertension or diagnosis of dysautonomia were excluded. Blood pressure was measured in supine position as well as after 3 and 5 min of standing.
  
  
  RESULTS
  Seventy subjects with Parkinson's disease and 145 controls were included. There were no statistically significant differences in gender and age between both groups. There was no difference in systolic blood pressure change between groups at 3 minutes but at 5 minutes a statistically significant difference was found (P=.03). For diastolic blood pressure a difference between both groups was present at three and five minutes (P=.02 and P=.007).
  
  
  CONCLUSIONS
  Patients with early Parkinson's disease have differences in orthostatic responses compared to healthy controls, these differences are more relevant at 5 minutes of standing.
authors.affiliation: Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, DF, México; Clínica de Movimientos Anormales, Instituto Nacional de Neurología y Neurocirugía, DF, México. Electronic address: mrodriguez@innn.edu.mx.
authors.forename: Mayela
authors.initials: M
authors.lastname: Rodríguez-Violante
authors.forename: Amin
authors.initials: A
authors.lastname: Cervantes-Arriaga
authors.forename: Daniela
authors.initials: D
authors.lastname: García-Ibarra
authors.forename: Teresa
authors.initials: T
authors.lastname: Corona
mesh_terms: D001794:Blood Pressure; D001795:Blood Pressure Determination; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D056888:Patient Positioning; D012720:Severity of Illness Index