title: Survival analysis of patients with chondrosarcomas of the pelvis.
abstract: BACKGROUND
  Studies for patients with pelvic chondrosarcomas are limited. This study determines the outcome of patients with pelvic chondrosarcomas, and whether there is any association with tumors' grade, type, stage, margins and pelvic location.
  
  
  METHODS
  We retrospectively studied 215 patients with pelvic chondrosarcomas. All patients had biopsy and histological diagnosis of their tumors followed by limb salvage or amputation. We staged patients using the Musculoskeletal Tumor Society system. We performed a univariate and multivariate analysis of the survival to death, local recurrence and metastasis with respect to grade, type (central vs. peripheral), stage, margins, and pelvic location, and the survival to death of patients with and without local recurrence.
  
  
  RESULTS
  Grade was the most important univariate and multivariate predictor of the survival of the patients. Dedifferentiation was associated with significantly lower overall survival. Peripheral chondrosarcomas predicted survival only in the univariate analysis. Surgical margins predicted local recurrence only in the multivariate analysis. Periacetabular location was associated with lower survival to death and local recurrence. The occurrence of local recurrence compromises the overall survival.
  
  
  CONCLUSIONS
  Grade was the most important predictor of the overall survival of patients with chondrosarcomas of the pelvis.
authors.affiliation: Department of Orthopaedics, The Istituto Ortopedico Rizzoli, University of Bologna, Bologna, Italy.
authors.forename: Andreas F
authors.initials: AF
authors.lastname: Mavrogenis
authors.forename: Andrea
authors.initials: A
authors.lastname: Angelini
authors.forename: Gabriele
authors.initials: G
authors.lastname: Drago
authors.forename: Biagio
authors.initials: B
authors.lastname: Merlino
authors.forename: Pietro
authors.initials: P
authors.lastname: Ruggieri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D002813:Chondrosarcoma / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010384:Pelvic Bones / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D055815:Young Adult