title: [Oral tadalafil on alternate days for erectile dysfunction that fails to respond to on-demand sildenafil: a report of 15 cases].
abstract: OBJECTIVE
  To sum up the experience in administering oral tadalafil on alternate days for the treatment of erectile dysfunction (ED) that fails to respond to on-demand medication.
  
  
  METHODS
  We retrospectively analyzed the clinical data of 15 cases of ED treated with oral tadalafil on alternate days from September 2010 to March 2012. All the patients had failed to respond to on-demand medication of sildenafil previously.
  
  
  RESULTS
  After 4 weeks of tadalafil treatment, 11 (73.3%) of the cases were remarkably improved, with significant difference in IIEF-5 scores before and after treatment (P < 0.05). Transient adverse reactions were observed in the other 4 cases, including mild headache in 2, slight backache in 1, and facial flush in 1.
  
  
  CONCLUSIONS
  Oral tadalafil on alternate days is safe and effective in the treatment of ED that fails to respond to on-demand medication of sildenafil.
authors.affiliation: Center of Reproductive Medicine, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning 110004, China. duqiang912@189.cn
authors.forename: Qiang
authors.initials: Q
authors.lastname: Du
authors.forename: Lian-Xiang
authors.initials: LX
authors.lastname: Gu
authors.forename: Ye
authors.initials: Y
authors.lastname: Miao
authors.forename: Xin
authors.initials: X
authors.lastname: Xing
authors.forename: Bo-Chen
authors.initials: BC
authors.lastname: Pan
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Song
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002243:Carbolines / Q000008:administration & dosage* / Q000627:therapeutic use; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines / Q000627:therapeutic use; D012189:Retrospective Studies; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*; D000068581:Tadalafil; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D002243:Carbolines; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068581:Tadalafil; D000068677:Sildenafil Citrate