title: Increased acylation stimulating protein levels in young obese males is correlated with systemic markers of oxidative stress.
abstract: OBJECTIVE
  As little is known about relationship between acylation stimulating protein (ASP) and oxidative stress, whether there is any link between ASP and oxidative stress in young obese males were investigated.
  
  
  METHODS
  Forty-five obese (median body mass index (BMI) = 36.99 (IQR = 3.65) kg m(-2)) male subjects (median age = 22 (IQR = 6) years) and 24 age-matched (median age = 22.5 (IQR = 4.8) years) healthy male volunteers (median body mass index (BMI) = 23.67 (IQR = 2.45) kg m(-2)) were recruited into the study. All obese subjects have BMI > 30 kg m(-2), while all controls have BMI < 25 kg m(-2).
  
  
  RESULTS
  Fasting plasma ASP, lipid hydroperoxide, high sensitivity C-reactive protein (hs-CRP), fasting insulin, triglyceride, LDL-cholesterol levels and HOMA-IR were higher, whereas the mean HDL-cholesterol levels and glutathione peroxidase (GPx) enzyme activity were significantly lower in obese subjects than controls. The linear regression analysis showed that lipid hydroperoxide was independently associated with only BMI, while ASP was independently associated with BMI and triglyceride.
  
  
  CONCLUSIONS
  The present data support the concept that obesity occurs under condition of compex interactions by adipokines, insulin, inflammation, and oxidative stress.
authors.affiliation: Division of Internal Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Celik
authors.forename: Fatih
authors.initials: F
authors.lastname: Tangi
authors.forename: Emrah
authors.initials: E
authors.lastname: Kilicaslan
authors.forename: Yavuz S
authors.initials: YS
authors.lastname: Sanisoglu
authors.forename: Cagatay
authors.initials: C
authors.lastname: Oktenli
authors.forename: Cihan
authors.initials: C
authors.lastname: Top
mesh_terms: D000215:Acylation; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D050260:Carbohydrate Metabolism; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003176:Complement C3; D005215:Fasting; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D016014:Linear Models; D050356:Lipid Metabolism; D008297:Male; D009765:Obesity / Q000378:metabolism*; D018384:Oxidative Stress; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; C038245:C3 protein, human; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003176:Complement C3; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D014280:Triglycerides; D002097:C-Reactive Protein; D005979:Glutathione Peroxidase