title: Mechanism of one-electron oxidation of metformin in aqueous solution.
abstract: Hydroxyl free radical-induced oxidation of metformin was studied in aqueous solution as a function of the pH. Hydroxyl free radicals were generated by gamma radiolysis of water and the oxidation end-products were quantified by high-performance liquid chromatography coupled to mass spectrometry (HPLC/MS), as a function of the radiation dose. This work is a joint experimental and theoretical (DFT) approach that has paved the way towards a comprehensive rationalization of the one-electron mechanisms of MTF oxidation, as a function of the pH.
authors.affiliation: INSERM UMR-S850, Faculté de Pharmacie, Université de Limoges, Limoges, France. patrick.trouillas@unilim.fr
authors.forename: P
authors.initials: P
authors.lastname: Trouillas
authors.forename: C
authors.initials: C
authors.lastname: Marchetti
authors.forename: D
authors.initials: D
authors.lastname: Bonnefont-Rousselot
authors.forename: R
authors.initials: R
authors.lastname: Lazzaroni
authors.forename: D
authors.initials: D
authors.lastname: Jore
authors.forename: M
authors.initials: M
authors.lastname: Gardès-Albert
authors.forename: F
authors.initials: F
authors.lastname: Collin
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004583:Electrons; D005720:Gamma Rays; D006863:Hydrogen-Ion Concentration; D017665:Hydroxyl Radical / Q000737:chemistry; D013058:Mass Spectrometry; D008687:Metformin / Q000737:chemistry*; D010084:Oxidation-Reduction; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water; D017665:Hydroxyl Radical; D008687:Metformin