title: Csi1 illuminates the mechanism and function of Rabl configuration.
abstract: The nuclear envelope not only compartmentalizes the genome but is also home to the SUN-KASH domain proteins, which play essential roles both in genome organization and in linking the nucleus to the cytoskeleton. In interphase fission yeast cells, centromeres are clustered near the nuclear periphery. A recent report demonstrates that the inner nuclear membrane SUN domain protein Sad1 and a novel protein Csi1 connect centromeres to the nuclear envelope and that centromere clustering during interphase is critical for the efficient capture of kinetochores by microtubules during mitosis.
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY, USA.
authors.forename: Haitong
authors.initials: H
authors.lastname: Hou
authors.forename: Scott P
authors.initials: SP
authors.lastname: Kallgren
authors.forename: Songtao
authors.initials: S
authors.lastname: Jia
mesh_terms: D015825:Chromosomes, Fungal; D003599:Cytoskeleton / Q000378:metabolism / Q000648:ultrastructure; D015966:Gene Expression Regulation, Fungal; D007399:Interphase / Q000235:genetics; D018386:Kinetochores / Q000378:metabolism* / Q000648:ultrastructure; D008677:Metaphase; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure; D009685:Nuclear Envelope / Q000378:metabolism* / Q000648:ultrastructure; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D012568:Schizosaccharomyces / Q000235:genetics* / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics* / Q000378:metabolism; D008941:Spindle Apparatus / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D009687:Nuclear Proteins; C093512:SAD1 protein, S pombe; D029702:Schizosaccharomyces pombe Proteins
keywords: Csi1; SPB; Sad1; centromere; kinetochore; nuclear envelope