title: Viruses and antiviral immunity in Drosophila.
abstract: Viral pathogens present many challenges to organisms, driving the evolution of a myriad of antiviral strategies to combat infections. A wide variety of viruses infect invertebrates, including both natural pathogens that are insect-restricted, and viruses that are transmitted to vertebrates. Studies using the powerful tools in the model organism Drosophila have expanded our understanding of antiviral defenses against diverse viruses. In this review, we will cover three major areas. First, we will describe the tools used to study viruses in Drosophila. Second, we will survey the major viruses that have been studied in Drosophila. And lastly, we will discuss the well-characterized mechanisms that are active against these diverse pathogens, focusing on non-RNAi mediated antiviral mechanisms. Antiviral RNAi is discussed in another paper in this issue.
authors.affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Sara
authors.initials: S
authors.lastname: Cherry
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D001103:Arboviruses / Q000276:immunology*; D029721:Drosophila Proteins / Q000276:immunology / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000276:immunology* / Q000821:virology; D020869:Gene Expression Profiling; D054884:Host-Pathogen Interactions; D006801:Humans; D007109:Immunity; D023421:Models, Animal; D010849:Picornaviridae / Q000276:immunology*; D034622:RNA Interference / Q000276:immunology; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism*
chemical_list: D000956:Antigens, Viral; D029721:Drosophila Proteins; D051193:Toll-Like Receptors; C439909:imd protein, Drosophila
keywords: Antiviral; Arbovirus; Arthropod-borne; Drosophila; Immunity; Virus