title: Copper-catalyzed synthesis of trifluoromethyl-substituted isoxazolines.
abstract: A mild and efficient copper-catalyzed trifluoromethylation reaction which involves the cyclization of oximes has been developed. This method provides a convenient access to a variety of useful CF3-containing 4,5-dihydroisoxazoles by constructing a C-CF3 bond and a C-O bond in one step.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: He
authors.forename: Lian-Hua
authors.initials: LH
authors.lastname: Li
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Yang
authors.forename: Yu-Qi
authors.initials: YQ
authors.lastname: Wang
authors.forename: Jian-Yi
authors.initials: JY
authors.lastname: Luo
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Liu
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007555:Isoxazoles / Q000737:chemistry*; D008745:Methylation; D010091:Oximes / Q000737:chemistry*
chemical_list: D006845:Hydrocarbons, Fluorinated; D007555:Isoxazoles; D010091:Oximes; D003300:Copper