title: Finger tapping clinimetric score prediction in Parkinson's disease using low-cost accelerometers.
abstract: The motor clinical hallmarks of Parkinson's disease (PD) are usually quantified by physicians using validated clinimetric scales such as the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). However, clinical ratings are prone to subjectivity and inter-rater variability. The PD medical community is therefore looking for a simple, inexpensive, and objective rating method. As a first step towards this goal, a triaxial accelerometer-based system was used in a sample of 36 PD patients and 10 age-matched controls as they performed the MDS-UPDRS finger tapping (FT) task. First, raw signals were epoched to isolate the successive single FT movements. Next, eighteen FT task movement features were extracted, depicting MDS-UPDRS features and accelerometer specific features. An ordinal logistic regression model and a greedy backward algorithm were used to identify the most relevant features in the prediction of MDS-UPDRS FT scores, given by 3 specialists in movement disorders (SMDs). The Goodman-Kruskal Gamma index obtained (0.961), depicting the predictive performance of the model, is similar to those obtained between the individual scores given by the SMD (0.870 to 0.970). The automatic prediction of MDS-UPDRS scores using the proposed system may be valuable in clinical trials designed to evaluate and modify motor disability in PD patients.
authors.affiliation: Movere Group, Cyclotron Research Centre, University of Liege, Sart Tilman B30, Liège, Belgium. julien.stamatakis@gmail.com
authors.forename: Julien
authors.initials: J
authors.lastname: Stamatakis
authors.forename: Jérome
authors.initials: J
authors.lastname: Ambroise
authors.forename: Julien
authors.initials: J
authors.lastname: Crémers
authors.forename: Hoda
authors.initials: H
authors.lastname: Sharei
authors.forename: Valérie
authors.initials: V
authors.lastname: Delvaux
authors.forename: Benoit
authors.initials: B
authors.lastname: Macq
authors.forename: Gaëtan
authors.initials: G
authors.lastname: Garraux
mesh_terms: D000054:Acceleration; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D019540:Area Under Curve; D003627:Data Interpretation, Statistical; D004185:Disability Evaluation; D004867:Equipment Design; D005260:Female; D005385:Fingers / Q000502:physiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009460:Neurologic Examination; D009462:Neurology / Q000295:instrumentation*; D010300:Parkinson Disease / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011597:Psychomotor Performance / Q000502:physiology*; D012372:ROC Curve