title: Wnt signalling in pituitary development and tumorigenesis.
abstract: Wnt signalling is activated in both pituitary organogenesis and its mature function. Wnt ligands and Wnt signalling pathways are critical for the regulation of the formation of the pituitary. In the mature pituitary, Wnt signalling pathways control cell activity and may stimulate cell proliferation in both physiological and pathological processes. This review compares Wnt signalling pathways active in the developing and mature pituitary and explores how this gives us further insight into the development of pituitary adenomas.
authors.affiliation: Endocrinology and Diabetes Group, Faculty of Medical and Human Sciences, Centre for Endocrinology and Diabetes, Institute of Human Development, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
authors.forename: T J G
authors.initials: TJ
authors.lastname: Chambers
authors.forename: A
authors.initials: A
authors.lastname: Giles
authors.forename: G
authors.initials: G
authors.lastname: Brabant
authors.forename: J R E
authors.initials: JR
authors.lastname: Davis
mesh_terms: D000818:Animals; D003397:Craniopharyngioma / Q000378:metabolism; D006801:Humans; D038081:Organogenesis; D010902:Pituitary Gland / Q000196:embryology / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway
chemical_list: D051153:Wnt Proteins
keywords: Wnt; adenoma; development; pituitary; tumorigenesis