title: Unconventional protein secretion: an evolving mechanism.
abstract: The process by which proteins are secreted without entering the classical endoplasmic reticulum (ER)-Golgi complex pathway, in eukaryotic cells, is conveniently called unconventional protein secretion. Recent studies on one such protein called Acb1 have revealed a number of components involved in its secretion. Interestingly, conditions that promote the secretion of Acb1 trigger the biogenesis of a new compartment called CUPS (Compartment for Unconventional Protein Secretion). CUPS form near the ER exit site but lack ER-specific proteins. Other proteins that share some of the features common with the secretion of Acb1 are interleukin-1β and tissue transglutaminase. Here I will review recent advances made in the field and propose a new model for unconventional protein secretion.
authors.affiliation: Centre for Genomic Regulation (CRG), Barcelona, Spain. Vivek.Malhotra@crg.eu
authors.forename: Vivek
authors.initials: V
authors.lastname: Malhotra
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D019143:Evolution, Molecular; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism*; D055571:Secretory Pathway / Q000502:physiology*
chemical_list: C508585:IL1B protein, human; D053583:Interleukin-1beta