title: Pancreatic surgery with vascular reconstruction in patients with locally advanced pancreatic neuroendocrine tumors.
abstract: BACKGROUND
  Pancreatic neuroendocrine tumors (PNET) are rare neoplasms with better prognosis than most pancreatic malignancies. Surgery of locally advanced PNET remains controversial, and the role of vascular reconstruction in this patient group has yet to be defined. The aim of this study was to evaluate the feasibility and outcome of pancreatic resections with vascular reconstruction in patients with locally advanced PNET.
  
  
  METHODS
  Retrospective analysis of patients who underwent pancreatic surgery with vascular reconstruction for locally advanced PNET at a single institution. Furthermore, a review of the relevant literature on the topic was performed.
  
  
  RESULTS
  Seven patients who had undergone vascular reconstruction for locally advanced PNET were identified. Four patients had liver metastases at time of surgery. Postoperative complications developed in four patients with no mortality. Median follow-up time of all patients was 21 (range, 3-58) months. Three patients had disease in remission after 58, 42 and 3 months, respectively. One patient died 35 months postoperatively due to progressive disease, whereas three patients had progression of disease after 21, 9, and 4 months postoperatively.
  
  
  CONCLUSIONS
  Pancreatic surgery with vascular reconstruction in patients with locally advanced PNET is feasible with acceptable outcome.
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0372, Oslo, Norway. svhaug@ous-hf.no
authors.forename: Sven-Petter
authors.initials: SP
authors.lastname: Haugvik
authors.forename: Knut Jørgen
authors.initials: KJ
authors.lastname: Labori
authors.forename: Anne
authors.initials: A
authors.lastname: Waage
authors.forename: Pål-Dag
authors.initials: PD
authors.lastname: Line
authors.forename: Øystein
authors.initials: Ø
authors.lastname: Mathisen
authors.forename: Ivar Prydz
authors.initials: IP
authors.lastname: Gladhaug
mesh_terms: D000368:Aged; D005240:Feasibility Studies; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000473:pathology / Q000601:surgery*; D010180:Pancreatectomy / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome; D019043:Vascular Neoplasms / Q000473:pathology / Q000601:surgery*; D014656:Vascular Surgical Procedures