title: Description of an efficacious behavioral peer-driven intervention to reduce racial/ethnic disparities in AIDS clinical trials.
abstract: AIDS clinical trials (ACTs) are critical to the development of new treatments for HIV infection. However, people of color living with HIV/AIDS are involved in ACTs at disproportionally low rates, with African-Americans experiencing the greatest under-representation. In this article, we describe the core elements and key characteristics of a highly efficacious multi-component peer-driven intervention (PDI) designed to increase rates of screening for and enrollment into ACTs among African-American and Latino/Hispanic individuals, by addressing the main complex, multi-level barriers they experience to ACTs. We discuss the process of developing the intervention, the theoretical models guiding its delivery format and content, and provide an overview of the intervention's components. We then use brief case studies to illustrate a number of key issues that may arise during intervention implementation. Finally, we describe lessons learned and provide recommendations for the PDI's uptake in clinical and clinical trials settings.
authors.affiliation: College of Nursing, New York University, 726 Broadway, 10th Floor, New York, NY 10003, USA. nrl4@nyu.edu
authors.forename: N R
authors.initials: NR
authors.lastname: Leonard
authors.forename: A
authors.initials: A
authors.lastname: Banfield
authors.forename: M
authors.initials: M
authors.lastname: Riedel
authors.forename: A S
authors.initials: AS
authors.lastname: Ritchie
authors.forename: D
authors.initials: D
authors.lastname: Mildvan
authors.forename: G
authors.initials: G
authors.lastname: Arredondo
authors.forename: C M
authors.initials: CM
authors.lastname: Cleland
authors.forename: M V
authors.initials: MV
authors.lastname: Gwadz
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000208:ethnology; D001741:Black or African American / Q000193:education / Q000523:psychology* / Q000706:statistics & numerical data; D001291:Attitude of Health Personnel; D002986:Clinical Trials as Topic / Q000523:psychology* / Q000592:standards / Q000706:statistics & numerical data; D005239:Fear / Q000523:psychology; D005260:Female; D007722:Health Knowledge, Attitudes, Practice / Q000208:ethnology*; D006630:Hispanic or Latino / Q000193:education / Q000523:psychology* / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000523:psychology; D010353:Patient Education as Topic / Q000379:methods; D062526:Patient Navigation / Q000379:methods / Q000458:organization & administration; D018579:Patient Selection; D010379:Peer Group; D015983:Selection Bias; D035502:Trust / Q000523:psychology