title: [Development of technology, of rheological and biopharmaceutical properties of new gel].
abstract: The purpose of this research is the development of technology for preparation of hydrogel Glysotrical and study its rheological and biopharmaceutical characteristics. Based on gel-forming chitosan, PEG-400, glycerol and Tween-80 a new composition of hydrogel - Glysotrical was developed. Rheological properties of Glysotrical, as well as biopharmaceutical properties of artificial (cellophane) and natural membrane (chicken and pork skin) were investigated by dialysis. Rheological properties of different concentrations of chitosan solution and gel Glysotrical prepared on their basis were studied. It was determined that gel derived from the 5% solution of chitosan meets the technological requirements (pH-5,5-6,0, melting point-75,0±1,07°C, dynamic viscosity - 890,6 ± 3,57 cps). Rheological properties of the hydrogel Glysotrical, prepared on the basis of a multi-component composition in different temperatures (20, 40, 60°C) were identified. It was found that shear of helium drug (458 H/m2, 355 H/m2) at 20° and 40°C is lower, and the value of dynamic viscosity (912spz, 602spz) higher than that of chitosan gel; the hydrogel is stable at 20° and 40°C. High kinetic activity of hydrogel with Tween-80 is observed. During 5 hours membrane maximum quantity of routine diffusion from helium mass into dialysate in cellophane is 57,54 ±0,51%; in normal skin chicken - 20,04±0,55%; in the skin of chicken treated with 2% citric acid - 23,14±0,45%; normal pig skin - 12,64±0,09%; in the skin of pigs, treated with acid - 15,08± 0,11%. The study showed that the gel Glysotrical at 10-22°C is maintained for 2 years. Physico-chemical, rheological, technological and biopharmaceutical research showed that 4% gel Glysotrical was good in treatment of dermatological diseases.
authors.forename: S Dzh
authors.initials: SD
authors.lastname: Mekhralieva
mesh_terms: D000818:Animals; D002645:Chickens; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology; D005990:Glycerol / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology; D011136:Polysorbates / Q000737:chemistry; D012212:Rheology / Q000379:methods*; D013552:Swine; D014783:Viscosity
chemical_list: D011136:Polysorbates; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D048271:Chitosan; D005990:Glycerol