title: Signaling networks of Rho GTPases in cell motility.
abstract: The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In this review, we summarize the upstream and downstream players from Rho GTPases that are mainly involved in actin polymerization leading to cell motility and potentially playing a role in cancer cell metastasis.
authors.affiliation: Department of Natural Science, The Lebanese American University, Beirut 1102 2801, Lebanon.
authors.forename: Samer
authors.initials: S
authors.lastname: Hanna
authors.forename: Mirvat
authors.initials: M
authors.lastname: El-Sibai
mesh_terms: D000199:Actins / Q000737:chemistry / Q000378:metabolism*; D002465:Cell Movement / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000235:genetics; D020741:rho GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D000199:Actins; D020741:rho GTP-Binding Proteins
keywords: Actin; Cancer; Motility; PI3K; Rho GTPases