title: Ovarian stimulation leads to a severe implantation defect in mice.
abstract: The aim of the present study was to evaluate whether ovarian stimulation could induce embryo implantation dysfunction in mice and to explore the possible mechanisms involved. Ovarian stimulation was performed with intraperitoneal injections of 0, 2.5, 5.0, 7.5 and 10.0 IU pregnant mare serum gonadotrophin followed by the same dose of human chorionic gonadotrophin 48h later. A dose-dependent implantation defect in stimulated mice was demonstrated, which can be mainly explained by premature luteolysis and secondary endometrial changes induced by an imbalance in oestradiol and progesterone.
authors.affiliation: Department of Chinese Herbs, Tongji School of Pharmacy, Wuhan 430030, China.
authors.forename: Shaorong
authors.initials: S
authors.lastname: Deng
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Jianwu
authors.initials: J
authors.lastname: Zeng
authors.forename: Linli
authors.initials: L
authors.lastname: Hu
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000009:adverse effects*; D003656:Decidua / Q000187:drug effects / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D010065:Embryo Implantation, Delayed; D004717:Endometrium / Q000187:drug effects* / Q000503:physiopathology; D004958:Estradiol / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000009:adverse effects; D006064:Gonadotropins, Equine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D003341:Luteolysis / Q000187:drug effects*; D051379:Mice; D010062:Ovulation Induction / Q000009:adverse effects*; D010929:Placentation / Q000187:drug effects; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D012720:Severity of Illness Index; D014591:Uterine Diseases / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D006064:Gonadotropins, Equine; D011374:Progesterone; D004958:Estradiol
keywords: corpus luteum; decidua; embryo; implantation dysfunction; mouse; ovarian stimulation