title: Drug precipitation inhibitors in supersaturable formulations.
abstract: Use of supersaturable formulations has been demonstrated as an effective approach to improve solubility and oral absorption of poorly water-soluble compounds. In supersaturable formulations, drug concentration exceeds the equilibrium solubility when the formulations are exposed to the gastrointestinal fluids and drug might precipitate before being absorbed, resulting in delayed response, and reduced efficacy or compromised bioavailability. Polymer based drug precipitation inhibitors have been used to inhibit or retard such precipitation. In this manner one can maintain a drug in the supersaturated concentration for an extended period of time, leading to significantly improved bioavailability of the poorly water-soluble drugs. This review article discusses different types of precipitation inhibitors, working hypotheses, and case studies with improved oral bioavailability.
authors.affiliation: Department of Chemical & Biological Engineering, Drexel University, 3100 Chestnut St., Philadelphia, PA 19104, United States.
authors.forename: Sen
authors.initials: S
authors.lastname: Xu
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Dai
mesh_terms: D011232:Chemical Precipitation; D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D003505:Cyclodextrins; D004364:Pharmaceutical Preparations; D011108:Polymers; D013501:Surface-Active Agents
keywords: Bioavailability; Drug precipitation; Poorly water-soluble compounds; Precipitation inhibitors; Supersaturable formulations