title: SHPing in different directions in platelet production.
abstract: In this issue of Blood, Mazharian and colleagues characterize Shp1 and Shp2 conditional knockout (KO) murine models, underscoring the role of these phosphatases not only on platelet function but also on megakaryocyte development and platelet counts and size.
authors.affiliation: University of Colorado.
authors.forename: Jorge
authors.initials: J
authors.lastname: Di Paola
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D017353:Gene Deletion; D008533:Megakaryocytes / Q000378:metabolism*; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000235:genetics*; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6 / Q000235:genetics*; D034061:Thrombopoiesis / Q000235:genetics*
chemical_list: D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; C516725:Ptpn11 protein, mouse; C509248:Ptpn6 protein, mouse