title: Cephalothin susceptibility testing as class representative for oral cephalosporins: is it time to move on?
abstract: Based on current epidemiologic and resistance trends, we propose reconsideration of the use of cephalothin susceptibility to predict susceptibility to oral narrow-spectrum cephalosporins among Enterobacteriaceae, particularly in predicting cephalexin susceptibility for urinary tract isolates.
authors.affiliation: Department of Infectious Diseases, Northwest Permanente, Portland, OR, USA. hien.m.nguyen@kp.org
authors.forename: Hien M
authors.initials: HM
authors.lastname: Nguyen
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Graber
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002506:Cephalexin / Q000494:pharmacology*; D002512:Cephalothin / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000254:growth & development; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology; D005189:False Positive Reactions; D006801:Humans; D008826:Microbial Sensitivity Tests; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology; D018440:beta-Lactam Resistance
chemical_list: D000900:Anti-Bacterial Agents; D002506:Cephalexin; D002512:Cephalothin
keywords: Antibiotics; Cephalothin; MIC; Susceptibility; Urinary tract infection