title: Patent ductus arteriosus in preterm infants is associated with cardiac autonomic alteration and predominant parasympathetic stimulation.
abstract: BACKGROUND
  Hemodynamic disorders in patent ductus arteriosus (PDA) may alter the stimulation of the autonomic nervous system.
  
  
  OBJECTIVE
  The objective of this study was to analyze the orthosympathetic-parasympathetic balance in preterm infants with PDA.
  
  
  METHODS
  Patients were included from consecutive admissions to Amiens University Hospital from 2009 to 2011. We defined a PDA group and a Control group (echographic criteria). For each patient, three 4-minutes segments of ECG were recorded during quiet sleep and the RR chronologic series were extracted, and spectral (Fourier Transform) and time-domain analyses were performed. For each parameter of heart rate variability (HRV), average of three measures was determined and analysed.
  
  
  RESULTS
  Forty-four patients were included for analysis. The total HRV power, LF/HF ratio and SDNN were lower in the PDA group (n = 22, gestational age 28.2 w ± 1.9) than in the Control group (n = 22, gestational age 28.8 w ± 2). The decrease in LF power destabilized the autonomic balance in favour of parasympathetic stimulation. After adjustment for postconceptional age, PDA was still associated with parameters of autonomic neural stimulation.
  
  
  CONCLUSIONS
  These results suggest association of PDA with predominance of parasympathetic stimulation in preterm infants. The mechanisms of homeostasis in patients with PDA are very complex and involve both circulatory adaptations and control by autonomic pathway. If confirmed, our results could be interesting for future researches aiming to verify the interest of new targeted therapies for the management of PDA.
authors.affiliation: Department of Paediatrics, Neonatal Intensive Care Unit, Amiens University Hospital, Amiens, France. goudsab2002@yahoo.fr
authors.forename: Sabrina
authors.initials: S
authors.lastname: Goudjil
authors.forename: Fatiha
authors.initials: F
authors.lastname: Imestouren
authors.forename: Christèle
authors.initials: C
authors.lastname: Chazal
authors.forename: Ghida
authors.initials: G
authors.lastname: Ghostine
authors.forename: Fabrice
authors.initials: F
authors.lastname: Wallois
authors.forename: André
authors.initials: A
authors.lastname: Leke
authors.forename: Guy
authors.initials: G
authors.lastname: Kongolo
mesh_terms: D016022:Case-Control Studies; D004374:Ductus Arteriosus, Patent / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000294:innervation; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000503:physiopathology*; D008297:Male; D010275:Parasympathetic Nervous System / Q000503:physiopathology*
keywords: Autonomic nervous system; Heart rate variability; Patent ductus arteriosus; Preterm infant; Spectral analysis