title: Alteration of muscle membrane excitability in sepsis: possible involvement of ciliary nervous trophic factor (CNTF).
abstract: One of the main factor involved neuromyopathy acquired in intensive care unit (ICU) appears to be sepsis. It induces the release of many pro- and anti-inflammatory factors which can directly modulate the muscle excitability. We have studied the effects of one of them: the ciliary nervous trophic factor (CNTF) which is a cytokine released in the early phase of sepsis. CNTF induces a decrease in the sodium current and an increase in resting potential as in sodium inversion potential. These effects could participate to the hypo-excitability observed during sepsis and could be involved in the ICU acquired neuromyopathy. As for TNFα, this early effect is mainly mediated by protein kinase C (PKC) activation and appears to be a reversible post-transcriptional effect.
authors.affiliation: CHRU Brest, Pôle ARSIBOU, Brest F-29200, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Guillard
authors.affiliation: Université de Brest, Faculté de Médecine et des Sciences de la Santé, EA 1274, Laboratoire de Physiologie, Brest F-29200, France; Université Européenne de Bretagne, Rennes F-35000, France; CHRU Brest, Pôle ARSIBOU, Brest F-29200, France.
authors.forename: Gildas
authors.initials: G
authors.lastname: Gueret
authors.affiliation: Université de Brest, Faculté de Médecine et des Sciences de la Santé, EA 1274, Laboratoire de Physiologie, Brest F-29200, France; Université Européenne de Bretagne, Rennes F-35000, France; CHRU Brest, Pôle ARSIBOU, Brest F-29200, France.
authors.forename: Maité
authors.initials: M
authors.lastname: Guillouet
authors.affiliation: Université de Brest, Faculté de Médecine et des Sciences de la Santé, EA 1274, Laboratoire de Physiologie, Brest F-29200, France; Université Européenne de Bretagne, Rennes F-35000, France; CHRU Brest, Pôle ARSIBOU, Brest F-29200, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Vermeersch
authors.affiliation: Université de Brest, Faculté de Médecine et des Sciences de la Santé, EA 1274, Laboratoire de Physiologie, Brest F-29200, France; Université Européenne de Bretagne, Rennes F-35000, France; CHRU Brest, Explorations Fonctionnelles Respiratoires, Brest F-29200, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Rannou
authors.affiliation: Université de Brest, Faculté de Médecine et des Sciences de la Santé, EA 1274, Laboratoire de Physiologie, Brest F-29200, France; Université Européenne de Bretagne, Rennes F-35000, France; CHRU Brest, Explorations Fonctionnelles Respiratoires, Brest F-29200, France.
authors.forename: Marie-Agnès
authors.initials: MA
authors.lastname: Giroux-Metges
authors.affiliation: Université de Brest, Faculté de Médecine et des Sciences de la Santé, EA 1274, Laboratoire de Physiologie, Brest F-29200, France; Université Européenne de Bretagne, Rennes F-35000, France. Electronic address: jpennec@univ-brest.fr.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Pennec
mesh_terms: D000818:Animals; D020934:Ciliary Neurotrophic Factor / Q000378:metabolism*; D005260:Female; D015640:Ion Channel Gating; D008564:Membrane Potentials; D009132:Muscles / Q000378:metabolism* / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000378:metabolism* / Q000503:physiopathology*; D012964:Sodium / Q000378:metabolism
chemical_list: D020934:Ciliary Neurotrophic Factor; D012964:Sodium