title: Efficacy and toxicity of factor Xa inhibitors.
abstract: Venous thromboembolism (VTE) is a serious disease that is often neglected, and effective and safe antithrombotic treatments are a public health priority. New antithrombotics such as rivaroxaban, apixaban, betrixaban, edoxaban, darexaban, TAK-442, LY517717, eribaxaban, otamixaban are being developed to overcome current therapeutic limitations. The new oral anticoagulants and parenteral otamixaban are under evaluation in clinical trials for VTE treatment, for VTE prevention in orthopedic surgery, for stroke prevention in patients with atrial fibrillation and for cardiovascular event prevention in patients with acute coronary syndrome. These antithrombotic agents directly and selectively inhibit factor Xa, and do not require coagulation monitoring and dose adjustment. Several of these drugs have shown promising results and have the potential to either replace or act as alternatives to traditional anticoagulants (heparins, vitamin K antagonists).
authors.affiliation: Assistance Publique-Hôpitaux de Marseille, Service de la Pharmacie à Usage Intérieur de l'Hôpital Nord,Marseille, France.
authors.forename: Maryna
authors.initials: M
authors.lastname: Bondarenko
authors.forename: Christophe
authors.initials: C
authors.lastname: Curti
authors.forename: Marc
authors.initials: M
authors.lastname: Montana
authors.forename: Pascal
authors.initials: P
authors.lastname: Rathelot
authors.forename: Patrice
authors.initials: P
authors.lastname: Vanelle
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D065427:Factor Xa Inhibitors; D006801:Humans; D016896:Treatment Outcome; D054556:Venous Thromboembolism / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D065427:Factor Xa Inhibitors