title: Fetal and neonatal alloimmune thrombocytopenia.
abstract: Fetomaternal alloimmune thrombocytopenia (FMAIT) is a relatively uncommon disease, but is the leading cause of severe thrombocytopenia in the newborn. It can cause severe complications and long-term disabilities. The main objective of screening is to reduce both the morbidity and mortality associated with FMAIT, primarily by preventing intracranial hemorrhage. However, controversy surrounds both pre- and antenatal management. This article discusses pathogenesis, screening, diagnosis, and both pre- and neonatal management of FMAIT.
authors.affiliation: Department of Obstetrics & Gynaecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de Los Andes, Chile.
authors.forename: J P
authors.initials: JP
authors.lastname: Espinoza
authors.forename: J
authors.initials: J
authors.lastname: Caradeux
authors.forename: Errol R
authors.initials: ER
authors.lastname: Norwitz
authors.forename: S E
authors.initials: SE
authors.lastname: Illanes
keywords: Fetomaternal alloimmune thrombocytopenia; Hemorrhage; Immunization; Platelet antigens