title: Ligand-inducible formation of RNA pseudoknot.
abstract: Here, we demonstrate that a series of naphthyridine derivatives, naphthyridine carbamate tetramer (NCTn), can bind to the RNA CGG/CGG triad comprised of two single-stranded regions of a hairpin loop and a tail. Complete suppression of the binding by a single mutation indicated simultaneous binding of NCTn between hairpin loop and single stranded tail, leading to the formation of NCTn-induced pseudoknot.
authors.affiliation: Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan.
authors.forename: Saki
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Changfeng
authors.initials: C
authors.lastname: Hong
authors.forename: Takahiro
authors.initials: T
authors.lastname: Otabe
authors.forename: Asako
authors.initials: A
authors.lastname: Murata
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakatani
mesh_terms: D001483:Base Sequence; D002219:Carbamates / Q000737:chemistry*; D053843:DNA Mismatch Repair; D008024:Ligands; D008958:Models, Molecular; D009287:Naphthyridines / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D018911:Trinucleotide Repeats
chemical_list: D002219:Carbamates; D008024:Ligands; D009287:Naphthyridines; D012313:RNA