title: Regional cerebral perfusion alterations in patients with mild cognitive impairment and Alzheimer disease using dynamic susceptibility contrast MRI.
abstract: OBJECTIVE
  The purpose of this study was to assess regional cerebral perfusion distribution in patients with Alzheimer disease (AD) or mild cognitive impairment (MCI) using dynamic susceptibility contrast magnetic resonance imaging.
  
  
  METHODS
  Regional changes of perfusion were evaluated in 34 patients with AD, 51 patients with MCI, and 23 healthy controls (HCs). Using region of interest analyses, regional cerebral blood flow (CBF), cerebral blood volume, and mean transit time were measured bilaterally in the hippocampus; the temporal, temporoparietal, frontal, and sensomotoric cortices; the anterior and posterior cingulate gyri; the lentiform nucleus; and the cerebellum.
  
  
  RESULTS
  A significant reduction of CBF in patients with AD compared to HCs was shown in the frontal and temporoparietal cortices bilaterally, the lentiform nuclei bilaterally, the left posterior cingulate gyrus, and the cerebellum. Compared with patients with MCI, patients with AD presented a reduction of CBF in the frontal cortices bilaterally, the left temporoparietal cortex, and the left anterior and posterior cingulate gyrus. In both hippocampi and the posterior cingulate gyrus, a trend to a slight increase of CBF in patients with MCI was noticed with a decrease in patients with AD.
  
  
  CONCLUSIONS
  Using dynamic susceptibility contrast magnetic resonance imaging, pathologic alterations of regional brain perfusion can be demonstrated in patients with AD compared to patients with MCI or HCs.
authors.affiliation: Department of Radiology E010, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. t.hauser@dkfz.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Hauser
authors.forename: Peter
authors.initials: P
authors.lastname: Schönknecht
authors.forename: Philipp A
authors.initials: PA
authors.lastname: Thomann
authors.forename: Lars
authors.initials: L
authors.lastname: Gerigk
authors.forename: Johannes
authors.initials: J
authors.lastname: Schröder
authors.forename: Romy
authors.initials: R
authors.lastname: Henze
authors.forename: Alexander
authors.initials: A
authors.lastname: Radbruch
authors.forename: Marco
authors.initials: M
authors.lastname: Essig
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001921:Brain / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D005682:Gadolinium