title: [Nodular cutaneous amyloidosis associated with Sjögren's syndrome].
abstract: BACKGROUND
  Cutaneous nodular amyloidosis is rare, and association with Sjögren's syndrome has been reported. We discuss the possible link between these two diseases based on a case we saw.
  
  
  METHODS
  A 78-year-old woman with Sjögren's syndrome ongoing for 17 years presented for evaluation of a waxy infiltrated lesion on her left leg that had appeared 6 months earlier. Histopathological examination revealed a deposit of homogenous eosinophilic material throughout the dermis consistent with amyloidosis. Immunohistochemical study showed these deposits to be AL immunoglobin light chains.
  
  
  CONCLUSIONS
  The association of cutaneous nodular amyloidosis and Sjögren's syndrome appears to be a distinct disease entity reflecting the polymorphic clinical spectrum of lymphoproliferative diseases related to Sjögren's syndrome.
authors.affiliation: Service d'oncodermatologie, hôpital Ambroise-Paré, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France. fatiza59@hotmail.fr
authors.forename: F Z
authors.initials: FZ
authors.lastname: Elfatoiki
authors.forename: E
authors.initials: E
authors.lastname: Funck Brentano
authors.forename: F
authors.initials: F
authors.lastname: Blanc
authors.forename: T
authors.initials: T
authors.lastname: Clerici
authors.forename: P
authors.initials: P
authors.lastname: Saiag
mesh_terms: D000368:Aged; D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D000974:Antibodies, Antinuclear / Q000097:blood / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001706:Biopsy; D002503:Centromere / Q000276:immunology; D004198:Disease Susceptibility; D004802:Eosinophilia / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D016393:Lymphoma, B-Cell; D010306:Parotid Gland / Q000473:pathology; D012793:Sialadenitis / Q000209:etiology; D012859:Sjogren's Syndrome / Q000150:complications*; D012871:Skin Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D013194:Staining and Labeling
chemical_list: D000682:Amyloid; D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001324:Autoantigens; D007146:Immunoglobulin lambda-Chains; C035356:SS-A antibodies; C035222:amyloid protein AL