title: Insulin concentrations in cerebellum and body balance in diabetic male rats: aerobic training effects.
abstract: Brain insulin has had widespread metabolic, neurotrophic, and neuromodulatory functions and has been involved in the central regulation of food intake and body weight, learning and memory, neuronal development, and neuronal apoptosis.
  
  
  OBJECTIVE
  The present study investigated the role of swimming training on cerebral metabolism on insulin concentrations in cerebellum and the body balance performance of diabetic rats.
  
  
  METHODS
  Forty Male Wistar rats were divided in four groups: sedentary control (SC), trained control (TC), sedentary diabetic (SD), and trained diabetic (TD). Diabetes was induced by alloxan (32mgkg b.w.), single dose injection. The mean blood glucose of diabetic groups was 367±40mg/dl. Training program consisted in swimming 5days/week, 1h/day, 8weeks, supporting a workload corresponding to 90% of maximal lactate steady state (MLSS). For the body balance testing rats were trained to traverse for 5min daily for 5-7days. All dependent variables were analyzed by one-way analysis of variance (ANOVA) and a significance level of p<0.05 was used for all comparisons.
  
  
  RESULTS
  The body balance testing scores were different between groups. Insulin concentrations in cerebellum were not different between groups.
  
  
  CONCLUSIONS
  It was concluded that in diabetic rats, aerobic training does not induce alterations on cerebellum insulin but induces important metabolic, hormonal and behavioral alterations which are associated with an improvement in glucose homeostasis, serum insulin concentrations and body balance.
authors.affiliation: UNESP - São Paulo State University, Rio Claro, Brazil. umarantes@hotmail.com
authors.forename: Luciana Mendonça
authors.initials: LM
authors.lastname: Arantes
authors.forename: Natalia Oliveira
authors.initials: NO
authors.lastname: Bertolini
authors.forename: Rodrigo Ferreira
authors.initials: RF
authors.lastname: de Moura
authors.forename: Maria Alice Rostom
authors.initials: MA
authors.lastname: de Mello
authors.forename: Eliete
authors.initials: E
authors.lastname: Luciano
mesh_terms: D000332:Aerobiosis; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism*; D003213:Conditioning, Psychological / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000523:psychology*; D006400:Hematocrit; D007328:Insulin / Q000378:metabolism*; D019344:Lactic Acid / Q000097:blood; D007858:Learning / Q000502:physiology; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D004856:Postural Balance / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D057185:Sedentary Behavior
chemical_list: D001786:Blood Glucose; D007328:Insulin; D019344:Lactic Acid
keywords: Aerobic training; Body balance; Insulin