title: [Localized prostate cancer at high risk of progression].
abstract: Localized prostate tumors have various clinical, biological and histopathological characteristics that lead to different progression profiles. High-risk prostate cancer has been classically defined by clinical examination, PSA levels and histopathological data. High-risk prostate cancer has usually a worse outcome, but classic stratification predictive of outcome for prostate cancer is a matter of debate concerning its accuracy. A great deal of scientific work have been deploy to prove that high-risk prostate cancer should be approached by teamwork including radio-hormone therapy, systemic treatment with long-term use of LH-RH and a radical prostatectomy with adequate lymph node dissection. Selection of patients is essential to define individualized therapeutic strategy and timing for every modality should come as a consensus of medical supported evidence. Accurate patient selection and multimodal treatment offer the best therapeutic option in high-risk prostate cancer.
authors.affiliation: Université Paris-Descartes, 75014 Paris, France. francois.rozet@imm.fr
authors.forename: Francois
authors.initials: F
authors.lastname: Rozet
mesh_terms: D018450:Disease Progression; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*; D018570:Risk Assessment