title: Breast and prostate cancer survivors in a diabetic cohort: results from the Living with Diabetes Study.
abstract: OBJECTIVE
  Diabetes is more common in cancer survivors than in the general population. The objective of the present study was to determine cancer frequency in a cohort of patients with diabetes and to examine demographic, clinical, and quality of life differences between cancer survivors and their cancer-free peers to inform better individualized care.
  
  
  METHODS
  Self-reported survey data from 3,466 registrants with type 2 diabetes from Australia's National Diabetes Services Scheme (NDSS) were analyzed to compare relevant variables between cancer survivors and cancer-free patients. Analyses were focused on breast and prostate cancer to reflect the most common cancers in women and men, respectively.
  
  
  RESULTS
  Five percent of diabetic women reported a history of breast cancer and 4.2% of men reported a history of prostate cancer. Diabetic patients with a history of breast or prostate cancer were older at time of survey and diabetes diagnosis, less likely to report metformin use (women), and more likely to have two or more comorbidities than their cancer-free peers. More diabetic prostate cancer survivors also reported problems with mobility and performing usual tasks. However, cancer-free diabetic subjects reported a lower diabetes-dependent quality of life than diabetic cancer survivors. There was no association between cancer survivorship and duration of diabetes, indices of glycemic control, obesity, or diabetic complications.
  
  
  CONCLUSIONS
  Cancer survivors comprise a significant minority of diabetic patients that are particularly vulnerable and may benefit from interventions to increase screening and treatment of other comorbidities and promote a healthy lifestyle.
authors.affiliation: Corresponding Author: Adedayo A. Onitilo, MSCR, Marshfield Clinic Weston Center, 3501 Cranberry Boulevard, Weston, WI 54476. onitilo.adedayo@marshfieldclinic.org.
authors.forename: Adedayo A
authors.initials: AA
authors.lastname: Onitilo
authors.forename: Maria
authors.initials: M
authors.lastname: Donald
authors.forename: Rachel V
authors.initials: RV
authors.lastname: Stankowski
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Engel
authors.forename: Gail
authors.initials: G
authors.lastname: Williams
authors.forename: Suhail A R
authors.initials: SA
authors.lastname: Doi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000150:complications*; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000150:complications*; D011788:Quality of Life; D012737:Sex Factors; D017741:Survivors; D055815:Young Adult
chemical_list: D008687:Metformin
keywords: Cancer; Cross-sectional survey; Diabetes, Patient characteristics; Metformin