title: Triterpenoid saponins with anti-myocardial ischemia activity from the whole plants of Clematis tangutica.
abstract: Four new triterpenoid saponins named clematangosides A-D (1-4) along with six known saponins (5-10) were isolated from the whole plants of Clematis tangutica. Their structures were determined by extensive spectral analysis and chemical evidences. All saponins were evaluated for their protective effects in hypoxia-induced myocardial injury model. Compounds 2-4, 6, and 10 exhibited anti-myocardial ischemia activities with ED50 values in the range of 75.77-127.22 µM.
authors.affiliation: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Min-Na
authors.initials: MN
authors.lastname: Yao
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Tang
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Tian
authors.forename: Min-Chang
authors.initials: MC
authors.lastname: Wang
authors.forename: Lan-Ju
authors.initials: LJ
authors.lastname: Ji
authors.forename: Miao-Miao
authors.initials: MM
authors.lastname: Xi
mesh_terms: D002236:Carbohydrate Conformation; D039324:Clematis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D017202:Myocardial Ischemia / Q000188:drug therapy*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*
chemical_list: D012503:Saponins; D014315:Triterpenes