title: Immunohistochemical analysis of thrombi retrieved during treatment of acute ischemic stroke: does stent-retriever cause intimal damage?
abstract: OBJECTIVE
  To provide evidence whether mechanical thrombectomy with stent-retrievers in the treatment of acute ischemic stroke causes intimal damage.
  
  
  METHODS
  This study analyzed thrombi retrieved by mechanical thrombectomy from cerebral arteries in 48 consecutive patients with acute ischemic stroke for the presence of endothelial cells using CD34 antibodies.
  
  
  RESULTS
  Of 48 thrombi analyzed, CD34-positive cells were absent in 20, present as isolated cells in 21, and found in clusters in 7 thrombi. We did not find any subendothelial vessel wall structures.
  
  
  CONCLUSIONS
  Our findings suggest that mechanical thrombectomy with stent-retrievers does not cause relevant intimal damage in acute ischemic stroke treatment. Clinical Trial Registration- URL: http://www.germanctr.de. Unique identifier: DRKS00004695.
authors.affiliation: Department of Neuroradiology, University Hospital Freiburg, Breisacherstrasse 64, D-79106 Freiburg, Germany.
authors.forename: Paramdeep
authors.initials: P
authors.lastname: Singh
authors.forename: Soroush
authors.initials: S
authors.lastname: Doostkam
authors.forename: Matthias
authors.initials: M
authors.lastname: Reinhard
authors.forename: Vera
authors.initials: V
authors.lastname: Ivanovas
authors.forename: Christian A
authors.initials: CA
authors.lastname: Taschner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000378:metabolism; D002533:Cerebral Angiography; D042783:Endothelial Cells / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D020521:Stroke / Q000209:etiology / Q000628:therapy*; D017131:Thrombectomy / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D016896:Treatment Outcome; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology
chemical_list: D018952:Antigens, CD34
keywords: immunohistochemistry; ischemic stroke; thrombectomy; thrombus