title: Deactivation of gold(I) catalysts in the presence of thiols and amines--characterisation and catalysis.
abstract: Thiols and amines, which are common heteroatom nucleophiles in gold-catalysed reactions, are known to dampen the reactivity of gold catalysts. In this article, the identity and activity of gold(I) catalysts in the presence of thiols and amines is investigated. In the presence of thioacid, thiophenol and thiol, digold with bridging thiolate complexes [{Au(L)}2(μ-SR)][SbF6] are formed and have been fully characterised by NMR and X-ray crystallography. In the presence of amines and anilines, complexes [LAu-NH2R][SbF6] are formed instead. All new isolated gold complexes were investigated for their catalytic activity in order to compare the level of deactivation in each species.
authors.affiliation: Institute of Chemical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Young
authors.forename: Samantha L J
authors.initials: SL
authors.lastname: Green
authors.forename: Georgina M
authors.initials: GM
authors.lastname: Rosair
authors.forename: Ai-Lan
authors.initials: AL
authors.lastname: Lee
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D050607:Organogold Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000588:Amines; D050607:Organogold Compounds; D013438:Sulfhydryl Compounds