title: Left ventricular reverse remodeling after transcatheter aortic valve implantation: a cardiovascular magnetic resonance study.
abstract: BACKGROUND
  In patients with severe aortic stenosis, left ventricular hypertrophy is associated with increased myocardial stiffness and dysfunction linked to cardiac morbidity and mortality. We aimed at systematically investigating the degree of left ventricular mass regression and changes in left ventricular function six months after transcatheter aortic valve implantation (TAVI) by cardiovascular magnetic resonance (CMR).
  
  
  METHODS
  Left ventricular mass indexed to body surface area (LVMi), end diastolic volume indexed to body surface area (LVEDVi), left ventricular ejection fraction (LVEF) and stroke volume (SV) were investigated by CMR before and six months after TAVI in patients with severe aortic stenosis and contraindications for surgical aortic valve replacement.
  
  
  RESULTS
  Twenty-sevent patients had paired CMR at baseline and at 6-month follow-up (N=27), with a mean age of 80.7±5.2 years. LVMi decreased from 84.5±25.2 g/m2 at baseline to 69.4±18.4 g/m2 at six months follow-up (P<0.001). LVEDVi (87.2±30.1 ml /m2vs 86.4±22.3 ml/m2; P=0.84), LVEF (61.5±14.5% vs 65.1±7.2%, P=0.08) and SV (89.2±22 ml vs 94.7±26.5 ml; P=0.25) did not change significantly.
  
  
  CONCLUSIONS
  Based on CMR, significant left ventricular reverse remodeling occurs six months after TAVI.
authors.forename: Alessio
authors.initials: A
authors.lastname: La Manna
authors.forename: Alessandra
authors.initials: A
authors.lastname: Sanfilippo
authors.forename: Davide
authors.initials: D
authors.lastname: Capodanno
authors.forename: Antonella
authors.initials: A
authors.lastname: Salemi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cadoni
authors.forename: Irene
authors.initials: I
authors.lastname: Cascone
authors.forename: Gesualdo
authors.initials: G
authors.lastname: Polizzi
authors.forename: Michele
authors.initials: M
authors.lastname: Figuera
authors.forename: Rosetta
authors.initials: R
authors.lastname: Pittalà
authors.forename: Carmelo
authors.initials: C
authors.lastname: Privitera
authors.forename: Corrado
authors.initials: C
authors.lastname: Tamburino
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D001705:Bioprosthesis; D006328:Cardiac Catheterization / Q000295:instrumentation; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation / Q000379:methods*; D006352:Heart Ventricles / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D013318:Stroke Volume; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling