title: Treatment of severe human metapneumovirus (hMPV) pneumonia in an immunocompromised child with oral ribavirin and IVIG.
abstract: BACKGROUND
  The clinical manifestations of human metapneumovirus (hMPV) infection resemble those of respiratory syncytial virus with the most severe disease occurring in infants, the elderly, chronically ill, and immunocompromised hosts.
  
  
  METHODS
  We present a case of a 2-year-old girl undergoing intensive chemotherapy for Burkitt lymphoma who developed severe hMPV pneumonia. Rapid and complete recovery was observed after treatment with oral ribavirin and intravenous immunoglobulin.
  
  
  CONCLUSIONS
  As hMPV can cause severe pneumonia in immunocompromised patients and due to the reports of effective treatment with ribavirin, clinical studies to elucidate the role of ribavirin in treatment of hMPV pneumonia may be needed.
authors.affiliation: *Division of Pediatrics, Unit of Hematooncology Department of †Pediatric Surgery and Intensive Care ‡Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: Lidija
authors.initials: L
authors.lastname: Kitanovski
authors.forename: Silvester
authors.initials: S
authors.lastname: Kopriva
authors.forename: Marko
authors.initials: M
authors.lastname: Pokorn
authors.forename: Majda B
authors.initials: MB
authors.lastname: Dolničar
authors.forename: Vladan
authors.initials: V
authors.lastname: Rajić
authors.forename: Milica
authors.initials: M
authors.lastname: Stefanović
authors.forename: Janez
authors.initials: J
authors.lastname: Jazbec
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D016756:Immunoglobulins, Intravenous; D029121:Metapneumovirus; D018184:Paramyxoviridae Infections / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D011024:Pneumonia, Viral / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D012254:Ribavirin / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous; D012254:Ribavirin