title: Multiple sclerosis and mitochondrial gene variations: a review.
abstract: Multiple sclerosis (MS) is a debilitating disease of the central nervous system. Its etiology is still an unanswered enigma; its symptoms are varied and unpredictable; and there is no cure for it. Genetics has been introduced as a contributing factor to MS. Not only may MS stem from nuclear gene variations/mutations, but also it may arise from mitochondrial gene variations/mutations. The association of mitochondrial DNA variations/mutations with the pathogenesis of MS has, so far, been analyzed by several studies. This paper reviews the literature with regard to MS and corresponding mitochondrial DNA variations.
authors.affiliation: Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. andalibsa@tbzmed.ac.ir
authors.forename: Sasan
authors.initials: S
authors.lastname: Andalib
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Talebi
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Sakhinia
authors.forename: Mehdi
authors.initials: M
authors.lastname: Farhoudi
authors.forename: Homayoun
authors.initials: H
authors.lastname: Sadeghi-Bazargani
authors.forename: Azadeh
authors.initials: A
authors.lastname: Motavallian
authors.forename: Yones
authors.initials: Y
authors.lastname: Pilehvar-Soltanahmadi
mesh_terms: D004272:DNA, Mitochondrial / Q000235:genetics; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial