title: Chromatin remodeling, BRCA1, SAHF and cellular senescence.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Tu
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Aird
authors.forename: Rugang
authors.initials: R
authors.lastname: Zhang
mesh_terms: D019313:BRCA1 Protein / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002460:Cell Line; D016922:Cellular Senescence; D042002:Chromatin Assembly and Disassembly; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism; D020868:Gene Silencing; D006570:Heterochromatin / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D019313:BRCA1 Protein; D019941:Cyclin-Dependent Kinase Inhibitor p16; D050759:Cyclin-Dependent Kinase Inhibitor p21; D006570:Heterochromatin; D009687:Nuclear Proteins; D016160:Retinoblastoma Protein; D014157:Transcription Factors; C084108:SMARCA4 protein, human; D004265:DNA Helicases
keywords: BRCA1; BRG1; DNA damage response; oncogene-induced senescence; pRB; pericentromeric heterochromatin; senescence-associated heterochromatin foci (SAHF)