title: Association of rs1800471 polymorphism of TGFB1 gene with chronic kidney disease occurrence and progression and hypertension appearance.
abstract: BACKGROUND
  Transforming growth factor β1 (TGF-β1) is a cytokine involved in the process of pathological tissue sclerosis, which is part of the pathophysiological mechanism of end stage renal disease development. The aim of the study was to evaluate the association of the single nucleotide polymorphism rs1800471 of the TGFB1 gene with chronic kidney disease (CKD) occurrence and progression as well as hypertension appearance.
  
  
  METHODS
  It was a case-control study where 109 patients with CKD and 111 very old people were enrolled. The association of the studied polymorphism with mentioned diseases was assessed in the whole study group as well as in the subgroups stratified according to the underlying etiology of CKD: nephropathy in type 1 diabetes (n = 13), chronic glomerulonephritis (n = 50) and chronic interstitial nephritis (n = 46).
  
  
  RESULTS
  No association of CKD progression with rs1800471 polymorphism was observed. The C allele was identified as the one associated with higher risk of the disease occurrence in the dominant model of inheritance (p = 0.035). The C allele in women, opposite to male gender, was associated with higher risk of CKD development (p = 0.038). GG genotype was associated with elevated risk of hypertension appearance (p = 0,0021).
  
  
  CONCLUSIONS
  Due to the lack of accordance with previously performed studies it is still impossible to state an unequivocal conclusion regarding the association between rs1800471 polymorphism of the TGFB1 gene and risk of CKD occurrence and progression as well as hypertension appearance. That is why it is necessary to perform further studies in this field.
authors.affiliation: Department of Internal Diseases, Diabetology and Nephrology, Medical University of Silesia, Zabrze, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Nabrdalik
authors.forename: Janusz
authors.initials: J
authors.lastname: Gumprecht
authors.forename: Piotr
authors.initials: P
authors.lastname: Adamczyk
authors.forename: Sylwia
authors.initials: S
authors.lastname: Górczyńska-Kosiorz
authors.forename: Joanna
authors.initials: J
authors.lastname: Zywiec
authors.forename: Władysław
authors.initials: W
authors.lastname: Grzeszczak
keywords: case-control study; genetic risk factors; kidney diseases; very old people