title: [Hypothyroidism incidence and thyrotropin serum levels in newborns].
abstract: BACKGROUND
  congenital hypothyroidism is the third sub-clinic hereditary disease in Mexico. Infants with total or partial underactive thyroid gland presented at birth showed high levels of thyrotropin. This allows identifying patients at risk for developing it through screening tests. The aim was to determinate the incidence of neonatal congenital hypothyroidism in newborns in our hospital as well as set the cut-off value in screening test.
  
  
  METHODS
  samples from 4049 cord blood of newborns were processed. TSH was measurement by ELISA. Probands with high values subsequently underwent to confirmatory testing TSH micro-particle immunoassay.
  
  
  RESULTS
  the results showed incidence of hypothyroidism of 1.2 per 1000 newborns. The cut-off value obtained in the screening test was 26.63 mUI/L.
  
  
  CONCLUSIONS
  TSH values showed a different distribution compared with previous studies in the Mexican population and also a higher hypothyroidism incidence.
authors.affiliation: Laboratorio de Análisis Clínico, Hospital Regional "Dr. Valentín Gómez Farías," Guadalajara, Jalisco, México. sergio7genetica@hotmail.com.
authors.forename: Luz Rosalba
authors.initials: LR
authors.lastname: Topete-González
authors.forename: Sergio Alberto
authors.initials: SA
authors.lastname: Ramirez-Garcia
authors.forename: Griselda Guadalupe
authors.initials: GG
authors.lastname: Macías-López
authors.forename: Rogelio
authors.initials: R
authors.lastname: Troyo-Sanromán
authors.forename: Irma Mirella
authors.initials: IM
authors.lastname: Ramos-Ramírez
authors.forename: María Elizabeth Margarita
authors.initials: ME
authors.lastname: Elizondo-Rueda
authors.forename: Nory
authors.initials: N
authors.lastname: Dávalos-Rodríguez
authors.forename: Jaime Guillermo
authors.initials: JG
authors.lastname: González-Gamez
authors.forename: Carlos Enrique
authors.initials: CE
authors.lastname: Cabrera-Pivaral
mesh_terms: D003409:Congenital Hypothyroidism / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008800:Mexico / Q000453:epidemiology; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013972:Thyrotropin
keywords: hypothyroidism; neonatal screening; thyrotropin