title: A Multiphysics Modeling Approach to Develop Right Ventricle Pulmonary Valve Replacement Surgical Procedures with a Contracting Band to Improve Ventricle Ejection Fraction.
abstract: Patients with repaired tetralogy of Fallot account for the majority of cases with late onset right ventricle (RV) failure. A new surgical procedure placing an elastic band in the right ventricle is proposed to improve RV function measured by ejection fraction. A multiphysics modeling approach is developed to combine cardiac magnetic resonance imaging, modeling, tissue engineering and mechanical testing to demonstrate feasibility of the new surgical procedure. Our modeling results indicated that the new surgical procedure has the potential to improve right ventricle ejection fraction by 2-7% which compared favorably with recently published drug trials to treat LV heart failure.
authors.affiliation: Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609.
authors.forename: Dalin
authors.initials: D
authors.lastname: Tang
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.forename: Tal
authors.initials: T
authors.lastname: Geva
authors.forename: Rahul
authors.initials: R
authors.lastname: Rathod
authors.forename: Haruo
authors.initials: H
authors.lastname: Yamauchi
authors.forename: Vasu
authors.initials: V
authors.lastname: Gooty
authors.forename: Alexander
authors.initials: A
authors.lastname: Tang
authors.forename: Mehmet H
authors.initials: MH
authors.lastname: Kural
authors.forename: Kristen L
authors.initials: KL
authors.lastname: Billiar
authors.forename: Glenn
authors.initials: G
authors.lastname: Gaudette
authors.forename: Pedro J
authors.initials: PJ
authors.lastname: Del Nido
keywords: Right ventricle; congenital heart disease; fluid-structural interaction; heart model; multiscale; pulmonary valve replacement