title: Synthesis and characterization of thiolated carboxymethyl chitosan-graft-cyclodextrin nanoparticles as a drug delivery vehicle for albendazole.
abstract: A new strategy for the synthesis of thiolated carboxymethyl chitosan-g-cyclodextrin nanoparticles by an ionic-gelation method is presented. The synthetic approach was based on the utilization of 1,6-hexamethylene diisocyanate during cyclodextrin grafting onto carboxymethyl chitosan. The use of the 1,6-hexamethylene diisocyanate resulted in reactions between cyclodextrin and active sites at the C6-position of chitosan, and preserved amino groups of chitosan for subsequent reactions with thioglycolic acid, as the thiolating agent, and tripolyphosphate, as the gelling counterion. Various methods such as scanning electron microscopy, rheology and in vitro release studies were employed to exhibit significant features of the nanoparticles for mucosal albendazole delivery applications. It was found that the thiolated carboxymethyl chitosan-g-cyclodextrin nanoparticles prepared using an aqueous solution containing 1 wt% of tripolyphosphate and having 115.65 (μmol/g polymer) of grafted thiol groups show both the highest mucoadhesive properties and the highest albendazole entrapment efficiency. The latter was confirmed theoretically by calculating the enthalpy of mixing of albendazole in the above thiolated chitosan polymer.
authors.affiliation: Young Researchers Club, South Tehran Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Ghazaleh
authors.initials: G
authors.lastname: Alamdarnejad
authors.forename: Alireza
authors.initials: A
authors.lastname: Sharif
authors.forename: Shahrouz
authors.initials: S
authors.lastname: Taranejoo
authors.forename: Mohsen
authors.initials: M
authors.lastname: Janmaleki
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Kalaee
authors.forename: Mohsen
authors.initials: M
authors.lastname: Dadgar
authors.forename: Mazyar
authors.initials: M
authors.lastname: Khakpour
mesh_terms: D015766:Albendazole / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000871:Anthelmintics / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001826:Body Fluids / Q000378:metabolism; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry; D003505:Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D006801:Humans; D007419:Intestinal Secretions / Q000378:metabolism; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000138:chemical synthesis / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000871:Anthelmintics; D020099:Coated Materials, Biocompatible; D003505:Cyclodextrins; D014677:Pharmaceutical Vehicles; D013438:Sulfhydryl Compounds; C514968:carboxymethyl-chitosan; D048271:Chitosan; D015766:Albendazole