title: The vitamin D receptor (VDR) gene polymorphisms in Turkish brain cancer patients.
abstract: Objective. It has been stated that brain cancers are an increasingly serious issue in many parts of the world. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of glioma and meningioma. Methods. We investigated the VDR Taq-I and VDR Fok-I gene polymorphisms in 100 brain cancer patients (including 44 meningioma cases and 56 glioma cases) and 122 age-matched healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism (RF LP). Results. VDR Fok-I ff genotype was significantly increased in meningioma patients (15.9%) compared with controls (2.5%), and carriers of Fok-I ff genotype had a 6.47-fold increased risk for meningioma cases. There was no significant difference between patients and controls for VDR Taq-I genotypes and alleles. Conclusions. We suggest that VDR Fok-I genotypes might affect the development of meningioma.
authors.affiliation: Department of Molecular Medicine, The Institute of Experimental Medicine, İstanbul University, Vakıf Gureba Caddesi, Capa, 34390 Istanbul, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Toptaş
authors.forename: Ali Metin
authors.initials: AM
authors.lastname: Kafadar
authors.forename: Canan
authors.initials: C
authors.lastname: Cacina
authors.forename: Saime
authors.initials: S
authors.lastname: Turan
authors.forename: Leman Melis
authors.initials: LM
authors.lastname: Yurdum
authors.forename: Nihal
authors.initials: N
authors.lastname: Yiğitbaşı
authors.forename: Muhammed Oğuz
authors.initials: MO
authors.lastname: Gökçe
authors.forename: Umit
authors.initials: U
authors.lastname: Zeybek
authors.forename: Ilhan
authors.initials: I
authors.lastname: Yaylım
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D003710:Demography; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008579:Meningioma / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors; D014421:Turkey
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human