title: Inhibition of mortalin expression reverses cisplatin resistance and attenuates growth of ovarian cancer cells.
abstract: The heat shock protein mortalin is frequently overexpressed in human malignancies. In this study, an assessment of mortalin expression using ovarian cancer tissue microarrays suggested that mortalin overexpression might be related to drug resistance. Using a short hairpin (sh) RNA approach, we evaluated the effect of reducing mortalin expression in vitro and in vivo. The results of our study show that elevated levels of mortalin expression increase cancer cell resistance to cisplatin-induced cytotoxicity and identify mortalin as a potential therapeutic target for improved treatment of drug-resistant ovarian cancer.
authors.affiliation: Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Li
authors.forename: Yizhou
authors.initials: Y
authors.lastname: Jiang
authors.forename: Ji
authors.initials: J
authors.lastname: Zuo
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D017209:Apoptosis; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism; D049109:Cell Proliferation; D002945:Cisplatin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000378:metabolism*
chemical_list: D018840:HSP70 Heat-Shock Proteins; C080352:mortalin; D002945:Cisplatin