title: Glutamic acid and its derivatives: candidates for rational design of anticancer drugs.
abstract: Throughout the history of human civilizations, cancer has been a major health problem. Its treatment has been interesting but challenging to scientists. Glutamic acid and its derivative glutamine are known to play interesting roles in cancer genesis, hence, it was realized that structurally variant glutamic acid derivatives may be designed and developed and, might be having antagonistic effects on cancer. The present article describes the state-of-art of glutamic acid and its derivatives as anticancer agents. Attempts have been made to explore the effectivity of drug-delivery systems based on glutamic acid for the delivery of anticancer drugs. Moreover, efforts have also been made to discuss the mechanism of action of glutamic acid derivatives as anticancer agents, clinical applications of glutamic acid derivatives, as well as recent developments and future perspectives of glutamic acid drug development have also been discussed.
authors.affiliation: Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi-110025, India. drimran_ali@yahoo.com
authors.forename: Imran
authors.initials: I
authors.lastname: Ali
authors.forename: Waseem A
authors.initials: WA
authors.lastname: Wani
authors.forename: Ashanul
authors.initials: A
authors.lastname: Haque
authors.forename: Kishwar
authors.initials: K
authors.lastname: Saleem
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry; D015195:Drug Design; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D013792:Thalidomide / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D018698:Glutamic Acid; D013792:Thalidomide