title: Novel tetranuclear triarylantimony(V) complexes with (±)-mandelic acid ligands: synthesis, characterization, in vitro cytotoxicity and DNA binding properties.
abstract: Four novel tetranuclear organoantimony(V) complexes [R3SbL]4, in which LH = (±)-mandelic acid and R = phenyl (1), 4-fluorophenyl (2), 3-fluorophenyl (3), 3,4,5-trifluorophenyl (4), were synthesized and characterized. The complexes displayed rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells and efficient CT-DNA binding.
authors.affiliation: Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059, P. R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Jiang
authors.forename: Handong
authors.initials: H
authors.lastname: Yin
authors.forename: Fangli
authors.initials: F
authors.lastname: Wang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Han
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Shuang
authors.initials: S
authors.lastname: Cheng
authors.forename: Min
authors.initials: M
authors.lastname: Hong
mesh_terms: D000965:Antimony / Q000737:chemistry*; D045744:Cell Line, Tumor / Q000187:drug effects; D004247:DNA / Q000737:chemistry; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005449:Fluorenes / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008333:Mandelic Acids / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D011485:Protein Binding; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D005449:Fluorenes; D008024:Ligands; D008333:Mandelic Acids; C041509:fluorene; D004247:DNA; D000965:Antimony; C037938:mandelic acid