title: Fast prediction of deleterious angiogenin mutations causing amyotrophic lateral sclerosis.
abstract: Certain single nucleotide polymorphisms causing missense mutations in angiogenin result in its loss-of-function and onset of amyotrophic lateral sclerosis (ALS). Although several such associations are reported across diverse ethnic groups, no method is available for predicting if a new mutation is deleterious. We present here a fast molecular dynamics based method for determining the mechanisms of functional loss caused by mutations, and attributes to ascertain whether a mutation causes ALS.
authors.affiliation: Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
authors.forename: Aditya K
authors.initials: AK
authors.lastname: Padhi
authors.forename: Suhas V
authors.initials: SV
authors.lastname: Vasaikar
authors.forename: Bhyravabhotla
authors.initials: B
authors.lastname: Jayaram
authors.forename: James
authors.initials: J
authors.lastname: Gomes
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000201:enzymology* / Q000209:etiology / Q000235:genetics*; D006801:Humans; D056004:Molecular Dynamics Simulation; D009154:Mutation; D011487:Protein Conformation; D012259:Ribonuclease, Pancreatic / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D012997:Solvents / Q000737:chemistry; D013997:Time Factors
chemical_list: D012997:Solvents; C046366:angiogenin; D012259:Ribonuclease, Pancreatic