title: Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells.
abstract: Our bodies are continuously exposed to various types of infectious pathogens. Vaccinations are the most cost effective way to protect our bodies against a variety of infectious microbes. The efficacy of most vaccines relies on protective antibody production and generation of memory B cells. These two key components develop mostly from B cells that participate in germinal center reactions. Recent efforts have highlighted the critical role of follicular helper CD4 T (Tfh) cells in the generation of germinal centers. Given that Bcl6 is a major transcription factor for Tfh differentiation, here we review recent developments in the understanding of signaling molecules that regulate Bcl6 expression in CD4 T cells, as a potential target for development of more efficacious vaccines.
authors.affiliation: Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, United States.
authors.forename: Youn Soo
authors.initials: YS
authors.lastname: Choi
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Yang
authors.forename: Shane
authors.initials: S
authors.lastname: Crotty
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000276:immunology; D006801:Humans; D051560:Proto-Oncogene Proteins c-bcl-6 / Q000276:immunology*; D015398:Signal Transduction; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D014612:Vaccines / Q000276:immunology
chemical_list: D016207:Cytokines; D051560:Proto-Oncogene Proteins c-bcl-6; D014612:Vaccines