title: Iridium-catalyzed borylation of secondary benzylic C-H bonds directed by a hydrosilane.
abstract: Most functionalizations of C-H bonds by main-group reagents occur at aryl or methyl groups. We describe a highly regioselective borylation of secondary benzylic C-H bonds catalyzed by an iridium precursor and 3,4,7,8-tetramethyl-1,10-phenanthroline as the ligand. The reaction is directed to the benzylic position by a hydrosilyl substituent. This hydrosilyl directing group is readily deprotected or transformed to other functional groups after the borylation reaction, providing access to a diverse set of secondary benzylboronate esters by C-H borylation chemistry.
authors.affiliation: Department of Chemistry, University of California, Berkeley , California 94270, United States.
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Cho
authors.forename: John F
authors.initials: JF
authors.lastname: Hartwig