title: Synthesis of N-furoyl chitosan and chito-oligosaccharides and evaluation of their antioxidant activity in vitro.
abstract: N-furoyl chitosan (NF-CS) and N-furoyl chitosan oligosaccharide (NF-COS) were prepared via acylation of chitosan and chitosan oligosaccharide. Their chemical structures and physical properties were characterized by Fourier transform infrared spectroscopy, (1)H NMR, X-ray diffraction, and elemental analysis. Results showed that the degrees of substitution of the derivatives were 0.68 and 0.72, respectively. Their antioxidant activities in vitro were further studied. The inhibition concentration of NF-CS at 50% (IC50) and the scavenging effect of NF-COS on DPPH were 1.3 and 0.76mgmL(-1), respectively. The derivatives also exhibited higher antioxidant activities than chitosan based on the reducing power and hydroxyl radical scavenging activities.
authors.affiliation: Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao 266100, China.
authors.forename: Di
authors.initials: D
authors.lastname: Zhao
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Wang
authors.forename: Liju
authors.initials: L
authors.lastname: Tan
authors.forename: Cuiyu
authors.initials: C
authors.lastname: Sun
authors.forename: Junni
authors.initials: J
authors.lastname: Dong
mesh_terms: D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000037:antagonists & inhibitors; D017665:Hydroxyl Radical / Q000037:antagonists & inhibitors; D009682:Magnetic Resonance Spectroscopy; D009844:Oligosaccharides / Q000737:chemistry*; D010084:Oxidation-Reduction; D010851:Picrates / Q000037:antagonists & inhibitors; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D009844:Oligosaccharides; D010851:Picrates; D017665:Hydroxyl Radical; D048271:Chitosan; C004931:1,1-diphenyl-2-picrylhydrazyl