title: The superficial glia limitans of mouse and monkey brain and spinal cord.
abstract: Using the double immunostaining method, the glia limitans on the surfaces of mouse and monkey brain and spinal cord were studied systematically. The results showed that the superficial glia limitans of mouse brain and spinal cord comprise a layer of surface astrocytes, while the glia limitans of monkey comprise a layer of foot-plates from marginal regions as described in histology and neuroscience textbooks. These surface astrocytes first appear at embryonic day (E)16 in spinal cord and at E17 on the ventral surface of the brain. At postnatal day (P)1, a layer of astrocytes covered the outermost regions of the spinal cord. At P10, the layer of astrocytes also covered the brain surface. The highest proliferation rates of surface astrocytes were found at E17 in the spinal cord and at E18 in the forebrain.
authors.affiliation: Department of Neurobiology, MOE Key Laboratory of Molecular Neurobiology, Ministry of Education, Neuroscience Research Centre of Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Liu
authors.forename: Zhaohuan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Burnstock
authors.forename: Cheng
authors.initials: C
authors.lastname: He
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Xiang
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000737:chemistry / Q000166:cytology*; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000166:cytology* / Q000196:embryology; D001923:Brain Chemistry; D049109:Cell Proliferation; D005455:Fluorescent Antibody Technique; D005865:Gestational Age; D008252:Macaca fascicularis; D051379:Mice; D008856:Microscopy, Fluorescence; D013116:Spinal Cord / Q000737:chemistry / Q000166:cytology* / Q000196:embryology
chemical_list: D015415:Biomarkers