title: A novel multi-component reaction to imidazo[4,5-g]-quinazolines.
abstract: The trace impurities discovered after extended storage of a 5-amino- benzimidazole library were determined as imidazo[4,5-g]quinazoline derivatives by extensive spectroscopic data analysis. The formation of this highly aromatic heterocyclic ring involved a novel multi-component reaction, using which several novel compounds were prepared. Its mechanism was deduced as a cascade of chemical transformations, including the formation of a Schiff's base, intramolecular hetero-Diels-Alder reaction, defluorination and dehydrogenation.
authors.affiliation: Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China. annaleelin@imm.ac.cn
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry*; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D011799:Quinazolines; D012545:Schiff Bases