title: Synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphates via activation of cyclic trimetaphosphate.
abstract: A procedure for the synthesis of dinucleoside 5'-pentaphosphates (Np5N) and nucleoside 5'-tetraphosphates (Np4) is described. The procedure relies on the activation of cyclic trimetaphosphate followed by a reaction with a nucleoside 5'-monophosphate (NMP) to give intermediates of type 3. Reaction of 3 with water or an NMP gives the desired products in yields ranging from 77 to 86%.
authors.affiliation: Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada, N2L 3G1.
authors.forename: Samy
authors.initials: S
authors.lastname: Mohamady
authors.forename: Scott D
authors.initials: SD
authors.lastname: Taylor
mesh_terms: D015226:Dinucleoside Phosphates / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D011122:Polyphosphates / Q000737:chemistry*
chemical_list: D015226:Dinucleoside Phosphates; D009705:Nucleosides; D009711:Nucleotides; D011122:Polyphosphates; C009293:trimetaphosphoric acid