title: Plant-derived natural products as sources of anti-quorum sensing compounds.
abstract: Quorum sensing is a system of stimuli and responses in relation to bacterial cell population density that regulates gene expression, including virulence determinants. Consequently, quorum sensing has been an attractive target for the development of novel anti-infective measures that do not rely on the use of antibiotics. Anti-quorum sensing has been a promising strategy to combat bacterial infections as it is unlikely to develop multidrug resistant pathogens since it does not impose any selection pressure. A number of anti-quorum sensing approaches have been documented and plant-based natural products have been extensively studied in this context. Plant matter is one of the major sources of chemicals in use today in various industries, ranging from the pharmaceutical, cosmetic, and food biotechnology to the textile industries. Just like animals and humans, plants are constantly exposed to bacterial infections, it is therefore logical to expect that plants have developed sophisticated of chemical mechanisms to combat pathogens. In this review, we have surveyed the various types of plant-based natural products that exhibit anti-quorum sensing properties and their anti-quorum sensing mechanisms.
authors.affiliation: Natural Sciences and Science Education AG, National Institute of Education, Nanyang Technological University, Singapore. chonglek.koh@nie.edu.sg
authors.forename: Chong-Lek
authors.initials: CL
authors.lastname: Koh
authors.forename: Choon-Kook
authors.initials: CK
authors.lastname: Sam
authors.forename: Wai-Fong
authors.initials: WF
authors.lastname: Yin
authors.forename: Li Ying
authors.initials: LY
authors.lastname: Tan
authors.forename: Thiba
authors.initials: T
authors.lastname: Krishnan
authors.forename: Yee Meng
authors.initials: YM
authors.lastname: Chong
authors.forename: Kok-Gan
authors.initials: KG
authors.lastname: Chan
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects; D001688:Biological Products / Q000494:pharmacology*; D006801:Humans; D010944:Plants / Q000737:chemistry*; D053038:Quorum Sensing / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D001688:Biological Products