title: The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?
abstract: The immunoglobulin superfamily member EMMPRIN (CD147) plays an important role in a number of organ systems, including the cardiovascular system. Here we review the contemporary understanding of EMMPRIN and EMMPRIN-associated sequelae in the course of atherosclerosis. A significant body of data documents the pivotal role of EMMPRIN in the complex processes of atherogenesis, atheroprogression, and acute atherosclerothrombosis, a role that goes beyond that of a mere marker of inflammation.
authors.affiliation: Deutsches Herzzentrum und I. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Nader
authors.initials: N
authors.lastname: Joghetaei
authors.forename: Andreas
authors.initials: A
authors.lastname: Stein
authors.forename: Robert A
authors.initials: RA
authors.lastname: Byrne
authors.forename: Christian
authors.initials: C
authors.lastname: Schulz
authors.forename: Lamin
authors.initials: L
authors.lastname: King
authors.forename: Andreas E
authors.initials: AE
authors.lastname: May
authors.forename: Roland
authors.initials: R
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D001158:Arteries / Q000276:immunology / Q000473:pathology*; D050197:Atherosclerosis / Q000276:immunology* / Q000473:pathology*; D051926:Basigin / Q000276:immunology*; D017364:Collagenases / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology
chemical_list: D051926:Basigin; D017364:Collagenases