title: Effect of storage conditions on the recrystallization of drugs in solid dispersions with crospovidone.
abstract: The physical stability of amorphous solid dispersions (SDs) is influenced by their storage conditions. The goal of this work was to investigate the factors affecting the recrystallization of drugs in SDs after storage under conditions of high temperature and high humidity. SDs of three drugs (dipyridamole, nifedipine and indomethacin) with different functional groups (amino, carbonyl and hydroxyl) and onset times for crystallization of the amorphous state were prepared using crospovidone (CrosPVP). All of the drugs in the SDs remained in an amorphous state at 25 °C/50% relative humidity (RH) in closed glass bottles for at least six months. Under conditions of high temperature (40 °C/75%RH/closed and 60 °C/open), differences in interactions between the hydrogen bond donors of the drugs and the amide carbonyl group of CrosPVP are essential factors for recrystallization of the drugs in the SDs. On the other hand, under condition of high humidity (40 °C/75%RH/open), in addition to the difference in the interaction between the drug and CrosPVP, the rate of increase in moisture content affects their recrystallization in SDs.
authors.affiliation: Pharmaceutical Research Laboratories, Kissei Pharmaceutical Co, Ltd , Azumino-city, Nagano , Japan and.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Shibata
authors.forename: Makiko
authors.initials: M
authors.lastname: Fujii
authors.forename: Ayako
authors.initials: A
authors.lastname: Suzuki
authors.forename: Naoya
authors.initials: N
authors.lastname: Koizumi
authors.forename: Ken
authors.initials: K
authors.lastname: Kanada
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamada
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D003460:Crystallization; D004176:Dipyridamole / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D004355:Drug Stability; D006358:Hot Temperature; D006813:Humidity; D007213:Indomethacin / Q000737:chemistry*; D009543:Nifedipine / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D004176:Dipyridamole; D011205:Povidone; D009543:Nifedipine; D007213:Indomethacin