title: Voltage-driven translocation behaviors of IgG molecule through nanopore arrays.
abstract: Nanopore-based biosensing has attracted more and more interests in the past years, which is also regarded as an emerging field with major impact on bio-analysis and fundamental understanding of nanoscale interactions down to single-molecule level. In this work, the voltage-driven translocation properties of goat antibody to human immunoglobulin G (IgG) are investigated using nanopore arrays in polycarbonate membranes. Obviously, the background ionic currents are modulated by IgG molecules for their physical place-holding effect. However, the detected ionic currents do 'not' continuously decrease as conceived; the currents first decrease, then increase, and finally stabilize with increasing IgG concentration. To understand this phenomenon, a simplified model is suggested, and the calculated results contribute to the understanding of the abnormal phenomenon in the actual ionic current changing tendency.
authors.affiliation: Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, School of Mechanics, Southeast University, Nanjing 210096, People's Republic of China. liulei@seu.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Jingjie
authors.initials: J
authors.lastname: Sha
authors.forename: Yue
authors.initials: Y
authors.lastname: Yang
authors.forename: Yaozong
authors.initials: Y
authors.lastname: Hou
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Ni
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Chen