title: Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling.
abstract: The oestrogen receptor alpha (ESR1) is a transcription factor that potentiates the response to diverse stimuli, including oestrogen and growth factors, in various tissue types. Its recruitment to the DNA is directly regulated by the chromatin landscape, inclusive of chromatin compaction and epigenetic modifications. In this review we discuss our current understanding of the interplay between ESR1 signaling and the chromatin landscape. We present how the chromatin landscape primes the lineage-specific response and contributes to stimuli-specific signaling. Finally, we discuss recent efforts to decipher the relationship between genetic and epigenetic as it relates to ESR1 signaling in breast cancer.
authors.affiliation: Ontario Cancer Institute, Princess Margaret Cancer Centre-University Health Network, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Electronic address: l.magnani@imperial.ac.uk.
authors.forename: Luca
authors.initials: L
authors.lastname: Magnani
authors.affiliation: Ontario Cancer Institute, Princess Margaret Cancer Centre-University Health Network, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Electronic address: mlupien@uhnres.utoronto.ca.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Lupien
mesh_terms: D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D044127:Epigenesis, Genetic; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D002843:Chromatin; D047628:Estrogen Receptor alpha
keywords: Chromatin; Epigenetic; Estrogen receptor; FOXA1; Pioneer factor; Transcriptional regulation