title: De novo CD5-positive diffuse large B-cell lymphomas show high specificity for cyclin D2 expression.
abstract: D cyclins positively regulate the cell cycle and mediate the pathogenesis of some lymphomas. Cyclin D1 overexpression is the hallmark of mantle cell lymphoma, whereas cyclins D2 and D3 are reportedly not as specific to certain lymphomas as cyclin D1. In this study, cyclin D2 was found to be overexpressed in 98% of de novo CD5-positive diffuse large B-cell lymphomas (DLBCLs) (50/51) and in 28% of CD5-negative DLBCLs (14/51). A statistically significant difference was observed between these two groups (p<0.0001). In contrast, no statistical difference was found in the cyclin D3 expression between CD5-positive (18/51) and CD5-negative (24/51) DLBCLs (p=0.23). Based on these findings, cyclin D2 is therefore considered to be closely associated with de novo CD5-positive DLBCLs. This insight may be useful for overcoming the inferior survival of this aggressive lymphoma.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1382856320966453.
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
authors.forename: Takuro
authors.initials: T
authors.lastname: Igawa
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Sato
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Takata
authors.forename: Noriko
authors.initials: N
authors.lastname: Iwaki
authors.forename: Takehiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Naoko
authors.initials: N
authors.lastname: Asano
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Maeda
authors.forename: Yorihisa
authors.initials: Y
authors.lastname: Orita
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakamura
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018956:CD5 Antigens / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology; D056742:Cyclin D2 / Q000378:metabolism*; D056743:Cyclin D3 / Q000378:metabolism; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D018956:CD5 Antigens; D056742:Cyclin D2; D056743:Cyclin D3