title: Optimizing the relaxivity of GdIII complexes appended to InP/ZnS quantum dots by linker tuning.
abstract: Three bimodal MRI/optical nanosized contrast agents with high per-nanoparticle relaxivity (up to 2523 mM(-1) s(-1) at 35 MHz and 932 mM(-1) s(-1) at 200 MHz) have been prepared connecting up to 115 tris-aqua Gd(III) complexes to fluorescent non-toxic InP/ZnS quantum dots. The structure of the linker has an important effect on the relaxivity of the final multimeric contrast agent.
authors.affiliation: CEA, INAC, SCIB, Laboratoire de Reconnaissance Ionique et Chimie de Coordination, CEA-Grenoble, UJF, LCIB, UMR-E 3 CEA-UJF, 38054 Grenoble Cedex 9, France.
authors.forename: Graeme J
authors.initials: GJ
authors.lastname: Stasiuk
authors.forename: Sudarsan
authors.initials: S
authors.lastname: Tamang
authors.forename: Daniel
authors.initials: D
authors.lastname: Imbert
authors.forename: Christelle
authors.initials: C
authors.lastname: Gateau
authors.forename: Peter
authors.initials: P
authors.lastname: Reiss
authors.forename: Pascal
authors.initials: P
authors.lastname: Fries
authors.forename: Marinella
authors.initials: M
authors.lastname: Mazzanti
mesh_terms: D003287:Contrast Media / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D045663:Quantum Dots; D019287:Zinc Sulfate / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D019287:Zinc Sulfate; D005682:Gadolinium