title: Orbital metastasis secondary to merkel cell carcinoma: case report and literature review.
abstract: BACKGROUND
  Merkel cell carcinoma is an aggressive malignancy often associated with metastatic spread, but has never been reported to metastasize to the orbit.
  
  
  METHODS
  An 80 year old male with metastatic Merkel cell carcinoma presented with ptosis and extraocular movement abnormalities, and was found to have a lesion of the orbit consistent with metastatic spread. The lesion responded favorably to radiation therapy.
  
  
  CONCLUSIONS
  Although the orbit is a frequent site of metastatic disease, this is the first reported case of presumed Merkel cell carcinoma metastasizing to the orbit.
authors.affiliation: Department of Ophthalmology, Queen's University, Kingston, Ontario. davin.johnson@queensu.ca
authors.forename: Davin
authors.initials: D
authors.lastname: Johnson
authors.forename: Daniel
authors.initials: D
authors.lastname: Warder
authors.forename: Marc-Emile
authors.initials: ME
authors.lastname: Plourde
authors.forename: Michael
authors.initials: M
authors.lastname: Brundage
authors.forename: Martin
authors.initials: M
authors.lastname: ten Hove
mesh_terms: D000369:Aged, 80 and over; D001706:Biopsy; D015266:Carcinoma, Merkel Cell / Q000556:secondary* / Q000628:therapy; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009918:Orbital Neoplasms / Q000556:secondary* / Q000628:therapy; D012878:Skin Neoplasms / Q000473:pathology*