title: [Frequency of subclinical thyroid problems among women during the first trimester of pregnancy].
abstract: BACKGROUND
  Thyroid hormones play an important role in fetal neural and cognitive development. Therefore thyroid abnormalities should be detected and treated early during pregnancy.
  
  
  OBJECTIVE
  To assess the frequency and risk factors for functional thyroid disorders during the first trimester of pregnancy.
  
  
  METHODS
  A blood sample was obtained from women during their first trimester of pregnancy, consulting in a prenatal care facility. Women with known thyroid diseases were excluded from the study. Thyroid stimulating hormone (TSH), total thyroxine (T4) and free thyroxine (fT4) were measured by electrochemoluminiscence. Antithyroid peroxidase antibodies (anti TPO) were measured by enzyme immunoassay.
  
  
  RESULTS
  Five hundred and ten women aged 25.7 ± 6.6 years were assessed. The frequency of clinical hypothyroidism was 0.6%, subclinical hypothyroidism 35.3% and clinical hyperthyroidism 1%. Five percent of women with hypothyroidism and 3.5% of euthyroid women had positive anti TPO antibodies. There was no association between the frequency of thyroid diseases and risk factors for thyroid diseases.
  
  
  CONCLUSIONS
  There is a high frequency of subclinical thyroid diseases among women consulting in this prenatal care clinic.
authors.affiliation: Departamento de Endocrinología, Hospital Sótero del Río, Chile. mosso@med.puc.cl
authors.forename: Lorena
authors.initials: L
authors.lastname: Mosso
authors.forename: Alejandra
authors.initials: A
authors.lastname: Martínez
authors.forename: María Paulina
authors.initials: MP
authors.lastname: Rojas
authors.forename: Paula
authors.initials: P
authors.lastname: Margozzini
authors.forename: Sandra
authors.initials: S
authors.lastname: Solari
authors.forename: Trinidad
authors.initials: T
authors.lastname: Lyng
authors.forename: Juan Andrés
authors.initials: JA
authors.lastname: Ortíz
authors.forename: Jorge
authors.initials: J
authors.lastname: Carvajal
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D002677:Chile / Q000453:epidemiology; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000453:epidemiology*; D015994:Incidence; D008423:Maternal Age; D009195:Peroxidase / Q000276:immunology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000453:epidemiology*; D011261:Pregnancy Trimester, First / Q000097:blood; D011446:Prospective Studies; D012307:Risk Factors; D013972:Thyrotropin; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D013972:Thyrotropin; D009195:Peroxidase