title: Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects.
abstract: Excess fructose intake causes hypertriglyceridemia and hepatic insulin resistance in sedentary humans. Since exercise improves insulin sensitivity in insulin-resistant patients, we hypothesized that it would also prevent fructose-induced hypertriglyceridemia. This study was therefore designed to evaluate the effects of exercise on circulating lipids in healthy subjects fed a weight-maintenance, high-fructose diet. Eight healthy males were studied on three occasions after 4 days of 1) a diet low in fructose and no exercise (C), 2) a diet with 30% fructose and no exercise (HFr), or 3) a diet with 30% fructose and moderate aerobic exercise (HFrEx). On all three occasions, a 9-h oral [(13)C]-labeled fructose loading test was performed on the fifth day to measure [(13)C]palmitate in triglyceride-rich lipoprotein (TRL)-triglycerides (TG). Compared with C, HFr significantly increased fasting glucose, total TG, TRL-TG concentrations, and apolipoprotein (apo)B48 concentrations as well as postfructose glucose, total TG, TRL-TG, and [(13)C]palmitate in TRL-TG. HFrEx completely normalized fasting and postfructose TG, TRL-TG, and [(13)C]palmitate concentration in TRL-TG and apoB48 concentrations. In addition, it increased lipid oxidation and plasma nonesterified fatty acid concentrations compared with HFr. These data indicate that exercise prevents the dyslipidemia induced by high fructose intake independently of energy balance.
authors.affiliation: Department of Physiology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Léonie
authors.initials: L
authors.lastname: Egli
authors.forename: Virgile
authors.initials: V
authors.lastname: Lecoultre
authors.forename: Fanny
authors.initials: F
authors.lastname: Theytaz
authors.forename: Vanessa
authors.initials: V
authors.lastname: Campos
authors.forename: Leanne
authors.initials: L
authors.lastname: Hodson
authors.forename: Philippe
authors.initials: P
authors.lastname: Schneiter
authors.forename: Bettina
authors.initials: B
authors.lastname: Mittendorfer
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Patterson
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Fielding
authors.forename: Philipp A
authors.initials: PA
authors.lastname: Gerber
authors.forename: Vittorio
authors.initials: V
authors.lastname: Giusti
authors.forename: Kaspar
authors.initials: K
authors.lastname: Berneis
authors.forename: Luc
authors.initials: L
authors.lastname: Tappy
mesh_terms: D000293:Adolescent; D001786:Blood Glucose; D018592:Cross-Over Studies; D004032:Diet; D004734:Energy Metabolism / Q000187:drug effects; D015444:Exercise / Q000502:physiology*; D005632:Fructose; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D005632:Fructose