title: Status and trends of diabetes in Chinese children: analysis of data from 14 medical centers.
abstract: BACKGROUND
  Childhood diabetes has become a growing concern. We conducted a study to evaluate the status and trend of diabetes from 14 medical centers in China. Pre-diabetic status among obese children was also noted.
  
  
  METHODS
  Hospital medical records were reviewed, and data of diabetes were collected from 1995 through 2010. We took every five years as a calculation unit to analyze the trend of new-onset diabetes. Data on obesity were collected in the recent five years.
  
  
  RESULTS
  A total of 4 337 836 patients aged 0-18 years were discharged from the 14 centers. The prevalence (per 100 000 persons) of new-onset type 1 diabetes, type 2 diabetes and other types of diabetes were 96.8, 8.0, and 3.3, respectively. The prevalence of type 1 diabetes increased from 90.9 to 92.9 and 101.4, while type 2 diabetes increased from 4.1 to 7.1 and 10.0 in every five years (P<0.0001). The increasing trend was significant from Southwest to East and North China (type 1 diabetes from 59.76 to 80.02 and 120.45, type 2 diabetes from 2.52 to 3.77 and 15.64 (per 100 000 persons) (all P<0.0001). Well developed areas in China had a higher prevalence compared to less developed areas [type 1 diabetes: 151.51 vs. 32.2 (per 100 000 persons); type 2 diabetes: 15.16 vs. 1.64 and others: 7.54 vs. 0.42 (per 100 000 persons)]. Of the 3153 obese children, 18.24% had impaired fasting glucose (IFG), 5.99% had impaired gulose tolerance (IGT), and 4% had combined IFG and IGT.
  
  
  CONCLUSIONS
  The prevalence of childhood diabetes in China has increased dramatically, with type 2 diabetes exceeding type 1 diabetes. The incidence rate of abnormal glucose metabolism in obese children has reached 28.26%.
authors.affiliation: Key Laboratory of Reproductive Genetics, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Jun-Fen
authors.initials: JF
authors.lastname: Fu
authors.forename: Li
authors.initials: L
authors.lastname: Liang
authors.forename: Chun-Xiu
authors.initials: CX
authors.lastname: Gong
authors.forename: Feng
authors.initials: F
authors.lastname: Xiong
authors.forename: Fei-Hong
authors.initials: FH
authors.lastname: Luo
authors.forename: Ge-Li
authors.initials: GL
authors.lastname: Liu
authors.forename: Pin
authors.initials: P
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Xin
authors.forename: Hui
authors.initials: H
authors.lastname: Yao
authors.forename: Lan-Wei
authors.initials: LW
authors.lastname: Cui
authors.forename: Xing
authors.initials: X
authors.lastname: Shi
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.forename: Lin-Qi
authors.initials: LQ
authors.lastname: Chen
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies