title: Barrett's esophagus and the risk of obstructive sleep apnea: a case-control study.
abstract: BACKGROUND
  Prior studies suggest that obstructive sleep apnea may be associated with gastroesophageal reflux disease, a strong risk factor for Barrett's esophagus. The goals of this pilot case-control study were to determine whether Barrett's esophagus patients have an increased likelihood of obstructive sleep apnea and to determine whether nocturnal gastroesophageal reflux symptoms affect the relationship between Barrett's esophagus and obstructive sleep apnea risk.
  
  
  METHODS
  Patients with Barrett's esophagus completed the Berlin Questionnaire, a validated survey instrument identifying subjects at high risk for obstructive sleep apnea. Two outpatient control groups were recruited: 1) EGD Group, subjects matched to Barrett's esophagus cases by age, race, and gender with esophagogastroduodenoscopy negative for Barrett's esophagus; and 2) Colonoscopy Group, patients getting colonoscopy. Rates of scoring at high risk for obstructive sleep apnea were compared. Respondents were also questioned regarding severity of their typical gastroesophageal reflux symptoms and presence of nocturnal gastroesophageal reflux symptoms.
  
  
  RESULTS
  The study included 287 patients (54 Barrett's esophagus, 62 EGD, and 171 colonoscopy subjects). Barrett's esophagus patients were slightly older than colonoscopy patients and more obese. 56% (n = 30) of Barrett's esophagus subjects scored at high risk for obstructive sleep apnea, compared with 42% (n = 26) of EGD subjects (OR 1.73, 95% CI [0.83, 3.62]) and 37% (n = 64) of colonoscopy patients (OR 2.08, 95% CI [1.12, 3.88]). The association between Barrett's esophagus and scoring at high risk for obstructive sleep apnea compared with colonoscopy patients disappeared after adjusting for age. Barrett's esophagus patients reported more severe typical heartburn and regurgitation symptoms than either control group. Among all subjects, patients with nocturnal reflux symptoms were more likely to score at high risk for obstructive sleep apnea than patients without nocturnal reflux.
  
  
  CONCLUSIONS
  In this pilot study, a high proportion of Barrett's esophagus subjects scored at high risk for obstructive sleep apnea. Having Barrett's esophagus was associated with more severe gastroesophageal reflux symptoms, and nocturnal reflux symptoms were associated with scoring at high risk for obstructive sleep apnea. The need for obstructive sleep apnea screening in Barrett's esophagus patients with nocturnal gastroesophageal reflux symptoms should be further evaluated.
authors.affiliation: Division of Gastroenterology and Liver Disease, Department of Medicine, University Hospitals Case Medical Center, 1100 Euclid Avenue Mailstop 5066, Cleveland, OH, 44106-5066, USA. linda.cummings@case.edu
authors.forename: Linda C
authors.initials: LC
authors.lastname: Cummings
authors.forename: Ninad
authors.initials: N
authors.lastname: Shah
authors.forename: Santo
authors.initials: S
authors.lastname: Maimone
authors.forename: Wajeeh
authors.initials: W
authors.lastname: Salah
authors.forename: Vijay
authors.initials: V
authors.lastname: Khiani
authors.forename: Amitabh
authors.initials: A
authors.lastname: Chak
mesh_terms: D001471:Barrett Esophagus / Q000453:epidemiology*; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000453:epidemiology*; D006356:Heartburn / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000453:epidemiology / Q000209:etiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010865:Pilot Projects; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology*; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology