title: Decrease in irisin in patients with chronic kidney disease.
abstract: Patients with chronic kidney disease have abnormal energy expenditure and metabolism. The mechanisms underlying altered energy expenditure in uremia are unknown and remain to be elucidated. Irisin is a peroxisome proliferator-activated receptor γ coactivator 1-α-dependent myokine, and it increases energy expenditure in the absence of changes in food intake or activity. We hypothesize that chronic kidney disease patients have altered irisin levels. We measured resting irisin levels in 38 patients with stage 5 chronic kidney disease and in 19 age- and sex-matched normal subjects. Plasma irisin levels were significantly decreased in chronic kidney disease patients (58.59%; 95% CI 47.9%-69.2%, p<0.0001). The decrease in irisin levels was inversely correlated with the levels of blood urea nitrogen and creatinine. Further association analysis revealed that irisin level is independently associated with high-density lipoprotein cholesterol level. Our results suggest that chronic kidney disease patients have lower than normal irisin levels at rest. Furthermore, irisin may play a major role in affecting high-density lipoprotein cholesterol levels and abnormal energy expenditure in chronic kidney disease patients.
authors.affiliation: Department of Cardiology, Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan. ocean.laboratory@me.com
authors.forename: Ming-Shien
authors.initials: MS
authors.lastname: Wen
authors.forename: Chao-Yung
authors.initials: CY
authors.lastname: Wang
authors.forename: Shuei-Liong
authors.initials: SL
authors.lastname: Lin
authors.forename: Kuo-Chun
authors.initials: KC
authors.lastname: Hung
mesh_terms: D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D003710:Demography; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D007200:Indican / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D032342:Muscle Cells / Q000187:drug effects / Q000378:metabolism; D018482:Muscle, Skeletal / Q000473:pathology; D051436:Renal Insufficiency, Chronic / Q000097:blood*
chemical_list: C577593:FNDC5 protein, human; D005353:Fibronectins; D003404:Creatinine; D007200:Indican