title: Early healing of hydroxyapatite-coated implants in grafted bone of zoledronic acid-treated osteoporotic rabbits.
abstract: BACKGROUND
  Resorption of grafted bone and delayed osseointegration of implants are main problems associated with alveolar bone augmentation in dental implantology, especially for patients with osteoporosis. The aim of this study is to investigate the early healing response of implants to systemic treatment of zoledronic acid (ZA) in autogenous grafted iliac bone of osteoporotic rabbits.
  
  
  METHODS
  Ovariectomy (OVX) or sham operation was performed in 46 rabbits, and osteoporotic changes were verified in animals receiving OVX 3 months later. The remaining animals were divided into three groups (n = 12): sham, OVX, and OVX with ZA treatment (ZA group). Autogenous iliac bone grafting was performed in bilateral tibiae, and hydroxyapatite-coated titanium implants were simultaneously placed into the grafted bone. The animals were sacrificed 2 and 8 weeks later for examination.
  
  
  RESULTS
  At both time points, systemic treatment of ZA efficiently promoted bone healing of implants in grafted bone, and all histologic and microcomputed tomography bone indices, including mineralized bone volume, implant-bone contact ratio, connectivity density, trabecular thickness, and trabecular number, were significantly increased in the ZA group compared with the OVX-only group (P <0.01); implant-bone contact rates in the ZA group were even restored to levels similar to those of sham-operated animals (P >0.05). Furthermore, biomechanical testing demonstrated that removal torque of implants was significantly increased in the ZA group compared with the OVX group (P <0.01).
  
  
  CONCLUSIONS
  Systemic treatment with ZA could efficiently promote early bone healing of implants in autogenous grafted bone of osteoporotic rabbits by increasing early osseointegration and fixation of implants.
authors.affiliation: College of Stomatology, Hebei United University, Tangshan City, Hebei Province, China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: Dong
authors.forename: Nan-Nan
authors.initials: NN
authors.lastname: Liao
authors.forename: Meng-Chun
authors.initials: MC
authors.lastname: Qi
authors.forename: Jin-Yuan
authors.initials: JY
authors.lastname: Li
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D064592:Autografts / Q000637:transplantation; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D002113:Calcification, Physiologic / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D015921:Dental Implants; D004164:Diphosphonates / Q000627:therapeutic use*; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D007085:Ilium / Q000601:surgery; D007093:Imidazoles / Q000627:therapeutic use*; D016348:Osseointegration / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy*; D010052:Ovariectomy / Q000379:methods; D011817:Rabbits; D013314:Stress, Mechanical; D013977:Tibia / Q000601:surgery; D013997:Time Factors; D019415:Torque; D060053:Transplant Donor Site / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects; D055114:X-Ray Microtomography / Q000379:methods; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D017886:Durapatite