title: Gimme a brake: HPK1 regulates LFA-1 and neutrophil traction.
abstract: In this issue of Blood, Jakob et al report that hematopoietic progenitor kinase 1 (HPK1) participates during signaling of neutrophil recruitment by acting as a regulator of the adhesiveness of the b2-integrin lymphocyte function-associated antigen 1 (LFA-1) during acute inflammation.
authors.affiliation: University of California at Davis.
authors.forename: Scott I
authors.initials: SI
authors.lastname: Simon
mesh_terms: D000210:Acute-Phase Reaction / Q000235:genetics*; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000502:physiology*; D020556:Neutrophil Infiltration / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*
chemical_list: D016169:Lymphocyte Function-Associated Antigen-1; C102102:hematopoietic progenitor kinase 1; D017346:Protein Serine-Threonine Kinases