title: Cutaneous squamous cell carcinoma: defining the high-risk variant.
abstract: With a lifetime incidence of approximately 10% in the general population, cutaneous squamous cell carcinoma (CSCC) is the second most common type of nonmelanoma skin cancer. Most CSCCs are benign and can be completely eradicated by surgery or other dermatological procedures. There is, however, a subgroup associated with an increased likelihood of lymph node metastases and, therefore, with high morbidity and mortality. This article analyzes the various factors that define aggressive CSCC. We propose a method for defining high-risk SCC on the basis of a series of major and minor criteria. This method will allow better prognostic evaluation and enable personalized management of patients with high-risk SCC, possibly leading to improved overall survival.
authors.affiliation: Departamento de Dermatología, Hospital de Manises, Valencia, Spain. antmarto@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Martorell-Calatayud
authors.forename: O
authors.initials: O
authors.lastname: Sanmartín Jimenez
authors.forename: J
authors.initials: J
authors.lastname: Cruz Mojarrieta
authors.forename: C
authors.initials: C
authors.lastname: Guillén Barona
mesh_terms: D000465:Algorithms; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy; D006801:Humans; D011379:Prognosis; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy