title: [Association between APOBEC3G polymorphisms and susceptibility to chronic hepatitis B].
abstract: OBJECTIVE
  To investigate the association between rs185983011 single-nucleotide polymorphisms (SNP) of apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G (APOBEC3G) and the susceptibility to chronic hepatitis B.
  
  
  METHODS
  The blood samples were collected from 186 healthy subjects and 159 patients with chronic hepatitis B. The rs185983011 SNP was detected and genotyped by sequencing with Sanger's method to analyze the relationship between rs185983011 SNP and chronic hepatitis B.
  
  
  RESULTS
  Only C/C and C/T genotypes of the alleles of rs185983011 SNP were found in the tested subjects, and the C/C genotype was predominant (97.7%). The distribution frequencies of rs185983011 SNP genotypes and alleles showed no significant difference between healthy subjects and patients with chronic hepatitis B (P>0.05).
  
  
  CONCLUSIONS
  The predominant genotype of rs185983011 SNP of APOBEC3G is C/C in the tested subjects, and rs185983011 SNP does not appear to associate with the susceptibility to chronic hepatitis B.
authors.affiliation: Department of Epidemiology, Southern Medical University, Guangzhou, China. zhiyiyou@126.com
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: You
authors.forename: Fuyuan
authors.initials: F
authors.lastname: Zhou
authors.forename: Xionghu
authors.initials: X
authors.lastname: Wang
authors.forename: Chuming
authors.initials: C
authors.lastname: Chen
authors.forename: Junhua
authors.initials: J
authors.lastname: Zhou
authors.forename: Dejian
authors.initials: D
authors.lastname: Zhao
authors.forename: Guifang
authors.initials: G
authors.lastname: Hu
mesh_terms: D000071480:APOBEC-3G Deaminase; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D003564:Cytidine Deaminase / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase