title: Free Radical Scavenging Potential and Essential Oil Composition of the Dorema glabrum Fisch. C.A. Mey Roots from Iran.
abstract: BACKGROUND
  Dorema glabrum is an endangered species that grow in Transcaucasia and North West of Iran. The plant has extensive uses e.g. as an herbal remedy or food additive in these regions. The chemical composition of hydrodistilled oil of D. glabrum growing in Iran was analyzed by GC-MS for the first time.
  
  
  METHODS
  The essential oil of air-dried roots was obtained by hydrodistillation using a Clevenger type apparatus. The oil was sub-jected to GC-MS analysis and its free radical scavenging properties were determined by DPPH method.
  
  
  RESULTS
  Thirty four constituents were identified that represented 81.6% of the total oil. The main compounds were delta-Cadinene (12.77%), beta-bisabolene (7.48%), alpha-Fenchyl acetate (6.32%), Copaene (5.68%) and Cubenol (5.42%). The essential oil had weak free radical scavenging properties with the RC50 value of 2.24 mg/mL.
  
  
  CONCLUSIONS
  Present work is the first report on chemical composition of the essential oil obtained from D. glabrum roots. GC-MS Analysis showed that the oil was rich in sesquiterpenes. It deems that weak free radical scavenging activity of the oil is due to absence of potent antioxidant compounds.
authors.affiliation: Department Drug Applied Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Solmaz
authors.initials: S
authors.lastname: Asnaashari
authors.forename: Elmira
authors.initials: E
authors.lastname: Dadizadeh
authors.forename: Amir Hossein
authors.initials: AH
authors.lastname: Talebpour
authors.forename: Morteza
authors.initials: M
authors.lastname: Eskandani
authors.forename: Hossein
authors.initials: H
authors.lastname: Nazemiyeh
keywords: DPPH; Dorema glabrum; Essential Oil; Sesquiterpenes