title: Osteomalacia induced by adefovir in patient with hepatitis B.
abstract: Osteomalacia is defined as a defect in mineralization of the bone matrix. We describe the case of a patient with chronic hepatitis B infection in whom treatment with adefovir induced renal phosphate loss with intense and sustained hypophosphatemia which derived in symptomatic osteomalacia.
authors.affiliation: Servicio de Reumatología, Hospital Cruces, Barakaldo, Vizcaya, España. Electronic address: nathali_r17@hotmail.com.
authors.forename: Mayra
authors.initials: M
authors.lastname: Nathali Rivas Zavaleta
authors.affiliation: Servicio de Reumatología, Hospital Cruces, Barakaldo, Vizcaya, España.
authors.forename: Sonia
authors.initials: S
authors.lastname: Guayambuco Romero
authors.affiliation: Servicio de Reumatología, Hospital Cruces, Barakaldo, Vizcaya, España.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Calabozo Raluy
authors.affiliation: Servicio de Reumatología, Hospital Cruces, Barakaldo, Vizcaya, España.
authors.forename: Fernando
authors.initials: F
authors.lastname: Pérez Ruiz
mesh_terms: D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D019694:Hepatitis B, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D063065:Organophosphonates / Q000009:adverse effects* / Q000627:therapeutic use; D010018:Osteomalacia / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; C053001:adefovir; D000225:Adenine
keywords: Adefovir; Hipofosfatemia; Hypophosphatemia; Osteomalacia