title: Changes in sex and non-sex hormones and distribution of erythrocyte antigens in reproductive age women with tumors of body of uterus in Adjara.
abstract: The aim the research was to study the hormonal state of reproductive age women with tumors of body of uterus. The quantitative changes of sex steroid hormones: progesterone (P), estradiol (E), testosterone (T), gonadotropine -Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH) were investigated. Distribution of ABO blood group antigens and Rh-Hr systems genetic variants in the blood of women living in Adjara Region was also studied. For study was used reproductive age women's blood with benign (fibromioma) and malignant (endometrial cancer) tumors of body of uterus (the middle age was 20-45 years). The determination of hormones was made by the enzymatic analysis method (ELAIZA). For the research of blood groups, were used the immunoserologic methods. The study have revealed that in blood of reproductive age women with benign and malignant tumors of body of uterus, level of estradiol was increased while levels of progesterone and testosterone were sharply reduced. Amount of Follicle-stimulating hormone and Luteinizing hormone were also increased. It's significant that, both hormones were sharply increased in case of cancer of body of uterus, in comparison with control group and benign tumor. According to distribution of ABO blood group phenotypes - O (I) phenotypic group of ABO system has its highest frequency in blood of women with cancer of body of uterus. Cancer of body of uterus is associated with O (I) phenotypic groups; benign tumor of body of uterus - with A(II) and AB(IV) phenotypic groups. Women with cc and EE genetic variants of Rh-Hr system have sensitivity to the development of benign and malignant tumors of body of uterus; women with ee genetic variant have lower sensitivity towards body of uterus cancer and sharply expressed sensitivity to uterus benign tumors. In women with malignant tumors of body of uterus the frequency of distribution of Rh-Hr system CC genetic variant was sharply reduced.
authors.affiliation: Batumi Shota Rustaveli State University, Faculty of Education and Sciences, Department of Biology, Batumi, Georgia.
authors.forename: I
authors.initials: I
authors.lastname: Nakashidze
authors.forename: N
authors.initials: N
authors.lastname: Kotrikadze
authors.forename: A
authors.initials: A
authors.lastname: Diasamidze
authors.forename: M
authors.initials: M
authors.lastname: Nagervadze
authors.forename: L
authors.initials: L
authors.lastname: Ramishvili
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics* / Q000276:immunology; D000328:Adult; D000483:Alleles; D000941:Antigens / Q000097:blood; D016889:Endometrial Neoplasms / Q000097:blood* / Q000235:genetics / Q000473:pathology; D004912:Erythrocytes / Q000276:immunology* / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone; D005846:Georgia (Republic); D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D011374:Progesterone / Q000097:blood; D012098:Reproduction; D013739:Testosterone / Q000097:blood; D014594:Uterine Neoplasms / Q000097:blood* / Q000235:genetics / Q000473:pathology
chemical_list: D000017:ABO Blood-Group System; D000941:Antigens; D006062:Gonadotropins; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone