title: [Research progress of alcohol-induced osteonecrosis of femoral head].
abstract: OBJECTIVE
  To review the research progress of alcohol-induced osteonecrosis of the femoral head (ONFH).
  
  
  METHODS
  Recent literature concerning alcohol-induced ONFH was reviewed and summarized.
  
  
  RESULTS
  Alcohol-induced ONFH accounte for approximately 1/3 of total ONFH. Alcohol intake and the incidence of ONFH has a significant dose-effect relationship. There are some correlations between alcohol-induced ONFH and lipid metabolism, secretion of corticosteroid, and some gene of alcohol or lipid metabolism.
  
  
  CONCLUSIONS
  The relationships between alcohol and lipid metabolism, and between alcohol and steroid are still the main direction of the research of ONFH. Gene level researches can not demonstrate the pathogenesis, therefore further research should be carried on.
authors.affiliation: Department of Orthopedics, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, 200233, P.R. China.
authors.forename: Di
authors.initials: D
authors.lastname: Gan
authors.forename: Changqing
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D000428:Alcohol Drinking / Q000009:adverse effects; D019973:Alcohol-Related Disorders / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000235:genetics / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects*; D005270:Femur Head / Q000473:pathology; D005271:Femur Head Necrosis / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D005938:Glucocorticoids / Q000097:blood / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000097:blood*; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors
chemical_list: D005938:Glucocorticoids; D008055:Lipids; D017395:Plasminogen Activator Inhibitor 1; D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase