title: Comparison of CaOH with MTA for direct pulp capping: a PBRN randomized clinical trial.
abstract: This practice-based, randomized clinical trial evaluated and compared the success of direct pulp capping in permanent teeth with MTA (mineral trioxide aggregate) or CaOH (calcium hydroxide). Thirty-five practices in Northwest PRECEDENT were randomized to perform direct pulp caps with either CaOH (16 practices) or MTA (19 practices). Three hundred seventy-six individuals received a direct pulp cap with CaOH (n = 181) or MTA (n = 195). They were followed for up to 2 yrs at regular recall appointments, or as dictated by tooth symptoms. The primary outcomes were the need for extraction or root canal therapy. Teeth were also evaluated for pulp vitality, and radiographs were taken at the dentist's discretion. The probability of failure at 24 mos was 31.5% for CaOH vs. 19.7% for MTA (permutation log-rank test, p = .046). This large randomized clinical trial provided confirmatory evidence for a superior performance with MTA as a direct pulp-capping agent as compared with CaOH when evaluated in a practice-based research network for up to 2 yrs.
authors.affiliation: Oregon Health & Science University, 611 S.W. Campus Drive, Portland, OR 97239, USA. hiltont@ohsu.edu
authors.forename: T J
authors.initials: TJ
authors.lastname: Hilton
authors.forename: J L
authors.initials: JL
authors.lastname: Ferracane
authors.forename: L
authors.initials: L
authors.lastname: Mancl
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017607:Aluminum Compounds / Q000627:therapeutic use*; D017610:Calcium Compounds / Q000627:therapeutic use*; D002126:Calcium Hydroxide / Q000627:therapeutic use*; D002648:Child; D055812:Community-Based Participatory Research; D003782:Dental Pulp / Q000502:physiology; D003785:Dental Pulp Capping / Q000379:methods*; D003789:Dental Pulp Exposure / Q000628:therapy; D017220:Dentin-Bonding Agents / Q000737:chemistry; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005899:Glass Ionomer Cements / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D010087:Oxides / Q000627:therapeutic use*; D057872:Pulp Capping and Pulpectomy Agents / Q000627:therapeutic use*; D011672:Pulpotomy / Q000379:methods; D016300:Radiography, Bitewing; D019279:Resin Cements / Q000737:chemistry; D012390:Root Canal Therapy; D017640:Silicates / Q000627:therapeutic use*; D014081:Tooth Extraction; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D017220:Dentin-Bonding Agents; D004338:Drug Combinations; D005899:Glass Ionomer Cements; D010087:Oxides; D057872:Pulp Capping and Pulpectomy Agents; D019279:Resin Cements; D017640:Silicates; C086631:mineral trioxide aggregate; C067790:Vitrabond; D002126:Calcium Hydroxide
keywords: clinical research; dental cavity liner; dental pulp; dental pulp exposure; pulp-capping agents; sodium hypochlorite