title: Chromoplexy: a new category of complex rearrangements in the cancer genome.
abstract: Widespread structural alterations of cancer genomes are increasingly observed in a broad spectrum of tumors. In a recent issue of Cell, Baca and colleagues describe large chains of rearrangements that coordinately affect multiple chromosomes in prostate cancer. This phenomenon of chromoplexy may define cancer subtypes and drive punctuated tumor evolution.
authors.affiliation: Departments of Medicine and Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. mshen@columbia.edu
authors.forename: Michael M
authors.initials: MM
authors.lastname: Shen
mesh_terms: D002869:Chromosome Aberrations; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics*