title: Multivariate optimization of capillary electrophoresis methods: a critical review.
abstract: In this article a review on the recent applications of multivariate techniques for optimization of electromigration methods, is presented. Papers published in the period from August 2007 to February 2013, have been taken into consideration. Upon a brief description of each of the involved CE operative modes, the characteristics of the chemometric strategies (type of design, factors and responses) applied to face a number of analytical challenges, are presented. Finally, a critical discussion, giving some practical advices and pointing out the most common issues involved in multivariate set-up of CE methods, is provided.
authors.affiliation: Department of Chemistry "U. Schiff", University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Orlandini
authors.forename: Roberto
authors.initials: R
authors.lastname: Gotti
authors.forename: Sandra
authors.initials: S
authors.lastname: Furlanetto
mesh_terms: D053801:Capillary Electrochromatography / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods; D004867:Equipment Design; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D012107:Research Design
keywords: Electromigration methods; Experimental design; Multivariate optimization; Review