title: Chronic cough in subjects with upper airway diseases - analysis of mechanisms and clinical applications.
abstract: Cough is the commonest respiratory symptom leading to a medical consultation. Although acute cough which is usually associated with respiratory viral infection is not a problem to manage, chronic cough is frequently a diagnostic and therapeutic challenge as it does not respond to usual treatments. Specific group of chronic coughers are considered to have upper airway diseases, lately categorized as having upper airway cough syndrome. There is an increasing pool of evidence that upper airway diseases have significant involvements in the regulation of cough reflex, indicating that they must be taken into considerations as major triggers of coughing in the patients. Here we summarize current literature and experiences on the pathogenesis of upper airway cough syndrome, and discuss further clinical applications.
authors.affiliation: Department of Pathophysiology & Simulation Centre, Jessenius Faculty of Medicine, Comenius University, Martin 036 01, Slovak Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Plevkova
authors.forename: Woo-Jung
authors.initials: WJ
authors.lastname: Song
keywords: Cough; Inflammation; Neuron; Rhinitis; Upper airways