title: Carotid artery intima-media thickness and the renin-angiotensin system.
abstract: Carotid artery intima-media thickness (IMT) is a biomarker for cardiovascular disease that also predicts the risk of cardiovascular mortality. Angiotensin-converting enzyme (ACE) inhibition is a unique therapeutic modality because it both treats hypertension and improves arterial health and cardiovascular disease outcomes. Controversy exists regarding the role of ACE inhibitors and angiotensin receptor blockers (ARBs) in IMT regression. Our article provides an update on how ACE inhibitors and ARBs could play a role in decreasing IMT.
authors.affiliation: Emory University School of Medicine, Atlanta, GA30322, USA.
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Johnson
authors.forename: Luke P
authors.initials: LP
authors.lastname: Brewster
mesh_terms: D057911:Angiotensin Receptor Antagonists / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D002339:Carotid Arteries / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D012084:Renin-Angiotensin System / Q000187:drug effects*; D018570:Risk Assessment; D017539:Tunica Intima / Q000187:drug effects / Q000473:pathology*
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors