title: Patients with metal-on-metal articulation in trapeziometacarpal total joint arthroplasty may have elevated serum chrome and cobalt.
abstract: Serum chrome and cobalt was measured in 50 patients with trapeziometacarpal total joint replacement with metal-on-metal articulation and compared with serum chrome and cobalt values in 23 patients with trapeziometacarpal total joint replacement with metal-on-polyethylene articulation. In 10 of 50 (20%) patients with metal-on-metal articulation, slightly elevated serum chrome or cobalt values were found compared with only one in 23 (4%) patients with metal-on-polyethylene articulation. All metal values were lower than accepted 'normal values' for metal-on-metal hip arthroplasty and so considered not to be a general health risk. However, the mean disabilities of the arm, shoulder and hand (DASH) score was 24 in patients with elevated serum chrome or cobalt compared with 10 in patients with normal metal values (p < 0.05) suggesting a local clinical effect of the elevated serum chrome or cobalt values. We recommend that patients with trapeziometacarpal total joint replacement with metal-on-metal articulation are followed with DASH score and radiological examination every 3-5 years and serum chrome and cobalt should be analysed in symptomatic cases to learn more about possible local complications leading to, or arising from, metal debris.
authors.affiliation: Department of Orthopaedics, Regional Hospital Holstebro, Lægårdvej, Denmark.
authors.forename: T B
authors.initials: TB
authors.lastname: Hansen
authors.forename: L
authors.initials: L
authors.lastname: Dremstrup
authors.forename: M
authors.initials: M
authors.lastname: Stilling
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019643:Arthroplasty, Replacement / Q000295:instrumentation*; D052737:Carpometacarpal Joints; D016022:Case-Control Studies; D002857:Chromium / Q000097:blood*; D003035:Cobalt / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D061825:Metal-on-Metal Joint Prostheses; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood* / Q000601:surgery; D011474:Prosthesis Design; D051222:Trapezium Bone
chemical_list: D002857:Chromium; D003035:Cobalt
keywords: Trapeziometacarpal total joint replacement; metal-on-metal articulation; serum chrome; serum cobalt; trapeziometacarpal joint osteoarthritis