title: [The effect of transmission electron microscopy on diagnosis of acute myeloid leukemia].
abstract: OBJECTIVE
  To analyze coincidence rate of acute myeloid leukemia (AML) sub-typing between transmission electron microscopy (TEM) and clinical discharge diagnosis.
  
  
  METHODS
  Reviewing sub-typing results of TEM, light microscopy, flow cytometric analyzing, molecular biological detection and karyotype in 793 AML cases, comparing their coincidence rates with discharge diagnosis to reveal advantages of AML sub-typing by TEM.
  
  
  RESULTS
  General coincidence rates of TEM, light microscopy, flow cytometric analyzing, molecular biological detection and karyotype on AML sub-typing were 63%, 59%, 52%, 47%, 26% and 23% respectively, and clinical coincidence rates of TEM on M1, M2a, M4 and M5, M6, M7, t (8; 21) and t (15; 17) were 39%, 34%, 17%, 74%, 50%, 73%, 87% and 89% respectively.
  
  
  CONCLUSIONS
  TEM has a higher coincidence rate in general AML sub-typing, especially strong screenings on t (15; 17), t (8; 21), M7, M5 and M6, but lower coincidence rates on M1, M2a and M4 sub-typing than other methods.
authors.affiliation: Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China.
authors.forename: Shu-xu
authors.initials: SX
authors.lastname: Dong
authors.forename: Shi-xuan
authors.initials: SX
authors.lastname: Zhao
authors.forename: Jin-hua
authors.initials: JH
authors.lastname: Liu
authors.forename: Ying-chang
authors.initials: YC
authors.lastname: Mi
authors.forename: Xiao-fan
authors.initials: XF
authors.lastname: Zhu
authors.forename: Yu-mei
authors.initials: YM
authors.lastname: Chen
authors.forename: Zhi-jian
authors.initials: ZJ
authors.lastname: Xiao
authors.forename: Yong-xin
authors.initials: YX
authors.lastname: Ru
authors.forename: Jian-xiang
authors.initials: JX
authors.lastname: Wang
mesh_terms: D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000175:diagnosis*; D046529:Microscopy, Electron, Transmission; D012189:Retrospective Studies