title: Short communication: High prevalence of vitamin D deficiency in HIV-infected and HIV-uninfected pregnant women.
abstract: Vitamin D deficiency is common in HIV-infected populations. In resource-limited settings, vitamin D deficiency has been shown to affect HIV disease progression and mortality in pregnant women, and also increases mother-to-child HIV transmission and mortality in their infants. This study sought to investigate vitamin D status in HIV-infected women compared to healthy controls in a high-income country setting and determine variables associated with vitamin D deficiency. We prospectively enrolled 40 women/infant pairs (16 HIV-infected women/HIV-exposed infant pairs and 24 uninfected/unexposed pairs). In serum cord blood, 25-hydroxyvitamin D [25(OH)D] concentrations were suboptimal (<30 ng/ml) in 100% of subjects from both groups. White race, non-Hispanic ethnicity was the only variable associated with higher serum 25(OH)D concentrations. This high prevalence of vitamin D deficiency, especially among HIV-infected women and their infants, deserves further investigation, as it may have a negative impact on maternal and infant health.
authors.affiliation: Emory University School of Medicine, Atlanta, Georgia 30322, USA. across3@emory.edu
authors.forename: Allison Ross
authors.initials: AR
authors.lastname: Eckard
authors.forename: Traci
authors.initials: T
authors.lastname: Leong
authors.forename: Ann
authors.initials: A
authors.lastname: Avery
authors.forename: Marina Duran
authors.initials: MD
authors.lastname: Castillo
authors.forename: Hector
authors.initials: H
authors.lastname: Bonilla
authors.forename: Norma
authors.initials: N
authors.lastname: Storer
authors.forename: Danielle
authors.initials: D
authors.lastname: Labbato
authors.forename: Alka
authors.initials: A
authors.lastname: Khaitan
authors.forename: Vin
authors.initials: V
authors.lastname: Tangpricha
authors.forename: Grace A
authors.initials: GA
authors.lastname: McComsey
mesh_terms: D018791:CD4 Lymphocyte Count; D005260:Female; D005312:Fetal Blood; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000453:epidemiology*; D015995:Prevalence; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D