title: Central diabetes insipidus in an HHV6 encephalitis patient with a posterior pituitary lesion that developed after tandem cord blood transplantation.
abstract: A 60-year-old myelodysplastic syndrome patient underwent tandem cord blood transplantation. The primary cord blood graft was rejected, and human herpesvirus 6 (HHV6) encephalitis developed after engraftment of secondary cord blood. Polyuria and adipsic hypernatremia were observed during treatment of the encephalitis. The patient died of bacteremia caused by methicillin-resistant Streptococcus epidermis. HHV6 infection in the posterior pituitary was confirmed on autopsy, as was infection of the hippocampus, but not of the hypothalamus. This is the first case report of central diabetes insipidus caused by an HHV6 posterior pituitary infection demonstrated on a pathological examination.
authors.affiliation: Department of Internal Medicine, Rinku General Medical Center, Japan. cli017@poh.osaka-med.ac.jp
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kawamoto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hatanaka
authors.forename: Masami
authors.initials: M
authors.lastname: Imakita
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Tamaki
mesh_terms: D064591:Allografts; D000754:Anemia, Refractory, with Excess of Blasts / Q000601:surgery*; D000998:Antiviral Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000209:etiology / Q000382:microbiology; D036101:Cord Blood Stem Cell Transplantation; D020790:Diabetes Insipidus, Neurogenic / Q000209:etiology*; D018792:Encephalitis, Viral / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D017809:Fatal Outcome; D005260:Female; D006084:Graft Rejection; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications; D010900:Pituitary Diseases / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D010904:Pituitary Gland, Posterior / Q000503:physiopathology / Q000821:virology*; D011183:Postoperative Complications / Q000209:etiology* / Q000382:microbiology / Q000821:virology; D012086:Reoperation; D019349:Roseolovirus Infections / Q000150:complications*; D013203:Staphylococcal Infections / Q000209:etiology / Q000382:microbiology; D057049:Thrombotic Microangiopathies / Q000209:etiology; D019172:Transplantation Conditioning / Q000009:adverse effects
chemical_list: D000998:Antiviral Agents