title: T helper-17 activation dominates the immunologic milieu of both amyotrophic lateral sclerosis and progressive multiple sclerosis.
abstract: MS (multiple sclerosis) and ALS (amyotrophic lateral sclerosis) differ in important respects, but common pathogenic features seem to be shared in these two diseases. To shed light on such features, immunophenotypic and functional analysis were performed in peripheral monocytes and T lymphocytes of ALS and primary progressive (PP) MS patients and healthy controls (HC). Results showed that TH1-, TH17-, and IL-6-driven inflammation characterize both diseases; this is unsuccessfully hampered by TH2 activation and, possibly, BDNF secretion. Results herein clarify the pathogenic similarities between ALS and PP-MS and could be helpful for the design of novel diagnostic and therapeutic approaches to ALS.
authors.affiliation: Don C. Gnocchi Foundation, ONLUS, Milano, 20148, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Saresella
authors.forename: Federica
authors.initials: F
authors.lastname: Piancone
authors.forename: Paola
authors.initials: P
authors.lastname: Tortorella
authors.forename: Ivana
authors.initials: I
authors.lastname: Marventano
authors.forename: Andrea
authors.initials: A
authors.lastname: Gatti
authors.forename: Domenico
authors.initials: D
authors.lastname: Caputo
authors.forename: Christian
authors.initials: C
authors.lastname: Lunetta
authors.forename: Massimo
authors.initials: M
authors.lastname: Corbo
authors.forename: Marco
authors.initials: M
authors.lastname: Rovaris
authors.forename: Mario
authors.initials: M
authors.lastname: Clerici
mesh_terms: D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000276:immunology*; D016207:Cytokines / Q000097:blood / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000276:immunology*; D018709:Statistics, Nonparametric; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D016207:Cytokines