title: Profilin 1: do we have a novel proteome-found biomarker predicting response to anticancer therapy?
abstract: About three decades ago, profilin 1 was described as a 15 kDa small protein. It was later shown that profilin 1 is a tumor suppressor in human carcinomas. Recent proteome-based data additionally demonstrated that the levels of profilin 1 expression could help to predict malignant tumor aggressiveness, response to anticancer therapy and risk of recurrence development.
authors.forename: Ira
authors.initials: I
authors.lastname: Skvortsova
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism*; D047628:Estrogen Receptor alpha / Q000737:chemistry* / Q000378:metabolism*; D005260:Female; D006801:Humans; D051304:Profilins / Q000737:chemistry* / Q000378:metabolism*; D020543:Proteome / Q000032:analysis*
chemical_list: D047628:Estrogen Receptor alpha; C495738:PFN1 protein, human; D051304:Profilins; D020543:Proteome
keywords: Cancer treatment; Cell biology; Profilin 1; Proteome approach; Therapy resistance