title: [Determination of migration of 25 primary aromatic amines from food contact plastic materials by gas chromatography-mass spectrometry].
abstract: A solid phase extraction (SPE) combination with gas chromatography-mass spectrometry (GC-MS) was developed for the determination of the migration of 25 primary aromatic amines (PAAs) from food contact plastic materials and articles. The samples were extracted by deionized water and 30 g/L acetic acid, and the pH value of the solution was adjusted to 8 - 10 with ammonia. The extracts were cleaned up and concentrated on an SPE column, then eluted by equal volume of methyl-tert-butyl ether and ethanol. The analysis of the target compounds was performed by GC-MS. The results indicated that the limits of detection were in the range of 0.4 -2.0 microg/kg for different PAAs. The recoveries and relative standard deviations (n = 7) of 10 microg/kg PAAs ranged from 51.6% -118.4% and 0.5% -9.8%, respectively, except the 2,4-diaminoanisole in the acid simulant. The effects of different experimental conditions such as the pH value and volume ratio of methyl-tert-butyl ether and ethanol were studied. The results showed that the method is accurate and stable, and could meet the requirement of the European Commission Regulation (EU) No 10/2011 for the determination of primary aromatic amines. It can be applied in the analysis of the primary aromatic amines in real food contact plastic material and article samples.
authors.affiliation: Shenzhen Entry-Exit Inspection and Quarantine Bureau, Shenzhen 518045, China. ccibly@126.com
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Chengfa
authors.initials: C
authors.lastname: Li
authors.forename: Daoqing
authors.initials: D
authors.lastname: Xiao
authors.forename: Feng
authors.initials: F
authors.lastname: Liang
authors.forename: Zhinan
authors.initials: Z
authors.lastname: Chen
authors.forename: Xuhui
authors.initials: X
authors.lastname: Schen
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Sun
authors.forename: Yongtao
authors.initials: Y
authors.lastname: Li
mesh_terms: D000588:Amines / Q000032:analysis* / Q000737:chemistry; D000814:Aniline Compounds / Q000032:analysis / Q000737:chemistry; D003297:Cooking and Eating Utensils; D005504:Food Analysis; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D010969:Plastics / Q000032:analysis / Q000737:chemistry*; D011140:Polyurethanes / Q000032:analysis / Q000737:chemistry; D052616:Solid Phase Extraction
chemical_list: D000588:Amines; D000814:Aniline Compounds; D010969:Plastics; D011140:Polyurethanes