title: Carbaryl-induced histopathologic alterations on testes of levantine frog, Pelophylax bedriagae (Anura: Ranidae).
abstract: The aim of the study was to investigate for the first time histopathologic effects of carbaryl on the testes of adult frog, Pelophylax bedriagae. Frogs were exposed to carbaryl once by oral gavage in concentrations of 0.05, 0.1 and 0.2 mg/g. After 96 h, frogs were euthanized and dissected. Histopathological changes were more prominent in medium- (0.1 mg/g) and high-dose (0.2 mg/g) groups than in the low-dose (0.05 mg/g) group. In the low-dose group, shrinkage of some seminiferous tubules was observed. In the medium-dose group, an enlargement of interstitial spaces and germ cell necrosis were detected. In the high-dose group, prominent tubule deformation was determined. Germ cell necrosis in seminiferous tubules was frequently seen. In addition, congestion, hemorrhage, cellular infiltration and fibrosis were detected. According to these findings, it is clear that carbaryl affects male fertility in P. bedriagae.
authors.affiliation: Zoology Section, Biology Department, Science Faculty, Ege University, Bornova-İzmir 35100, Turkey. ozlem.cakici@ege.edu.tr
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Çakıcı
mesh_terms: D000818:Animals; D012721:Carbaryl / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005298:Fertility / Q000187:drug effects; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D011897:Random Allocation; D011898:Ranidae / Q000378:metabolism*; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D023382:Toxicity Tests, Acute; D014421:Turkey; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D007306:Insecticides; D014874:Water Pollutants, Chemical; D012721:Carbaryl