title: Can enoxaparin reduce thromboembolism related events after primary TKA in Asian patients?
abstract: The purpose of this study was to investigate the efficacy and safety of enoxaparin in preventing venous and arterial thromboembolism related events after primary total knee arthroplasty (TKA) in Asian patients. Four hundred twenty nine patients (621 TKAs) did not receive thromboprophylaxis after TKA and 907 patients (1,336 TKAs) received enoxaparin after the procedure. We assessed clinically significant venous and arterial thromboembolism related events and bleeding complications. Total thromboembolism related events occurred in 13 patients (3.03%) without thromboprophylaxis and 17 patients (1.87%) with enoxaparin (P = 0.183). Our study showed that the incidence of clinically significant thromboembolism related events after TKA was very low in Asian patients. Enoxaparin had no benefits in reducing thromboembolism related events in Asian patients.
authors.affiliation: Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.
authors.forename: Geon-Hyeong
authors.initials: GH
authors.lastname: Kim
authors.forename: Beom-Yong
authors.initials: BY
authors.lastname: Park
authors.forename: Tae-Yong
authors.initials: TY
authors.lastname: Bae
authors.forename: Jin-Woo
authors.initials: JW
authors.lastname: Kang
authors.forename: Yong
authors.initials: Y
authors.lastname: In
mesh_terms: D000368:Aged; D001168:Arthritis / Q000601:surgery*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D044466:Asian People; D017984:Enoxaparin / Q000627:therapeutic use*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D013923:Thromboembolism / Q000208:ethnology / Q000209:etiology / Q000517:prevention & control*
chemical_list: D017984:Enoxaparin; D005343:Fibrinolytic Agents
keywords: enoxaparin; thromboembolism; thromboprophylaxis; total knee arthroplasty