title: Metabolomic analysis of sun exposed skin.
abstract: It is very well known that exposure of skin to sun chronically accelerates the mechanism of aging as well as making it more susceptible toward skin cancer. This aspect of aging has been studied very well through genomics and proteomics tools. In this study we have used a metabolomic approach for the first time to determine the differences in the metabolome from full thickness skin biopsies from sun exposed and sun protected sites. We have primarily investigated the energy metabolism and the oxidative pathway in sun exposed skin. Biochemical pathway analysis revealed that energy metabolism in photoexposed skin is predominantly anaerobic. The study also validated the increased oxidative stress in skin.
authors.affiliation: Johnson & Johnson Consumer Companies Inc., 199 Grandview Road, Skillman, NJ 08558, USA. mrandha1@its.jnj.com
authors.forename: Manpreet
authors.initials: M
authors.lastname: Randhawa
authors.forename: Michael
authors.initials: M
authors.lastname: Southall
authors.forename: Samantha Tucker
authors.initials: ST
authors.lastname: Samaras
mesh_terms: D000328:Adult; D001706:Biopsy; D004734:Energy Metabolism / Q000528:radiation effects*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D055442:Metabolome; D008875:Middle Aged; D018384:Oxidative Stress; D012867:Skin / Q000378:metabolism / Q000528:radiation effects*; D013472:Sunlight