title: The C-kit receptor-mediated signal transduction and tumor-related diseases.
abstract: As an important member of tyrosine kinase family, c-kit receptor causes specific expression of certain genes, regulates cell differentiation and proliferation, resists cell apoptosis, and plays a key role in tumor occurrence, development, migration and recurrence through activating the downstream signaling molecules following interaction with stem cell factor (SCF). The abnormality of SCF/c-kit signaling pathway is closely related to some certain tumors. The discovery of c-kit receptor-targeted drugs has promoted clinical-related cancer's diagnosis and treatment. In this paper, we review recent research progress on c-kit receptor-mediated signal transduction and its potential therapeutic application as a target in tumor-related diseases.
authors.affiliation: Department of Biopharmaceutical Science, College of Pharmaceutical Sciences, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou, 310014, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liang
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Wu
authors.forename: Bing-Jia
authors.initials: BJ
authors.lastname: Chen
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D003001:Cloning, Molecular; D019281:Dimerization; D016503:Drug Delivery Systems; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics*; D015723:Gene Library; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008954:Models, Biological; D008958:Models, Molecular; D015394:Molecular Structure; D019009:Proto-Oncogene Proteins c-kit / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D019089:Stem Cell Factor / Q000378:metabolism*
chemical_list: D019089:Stem Cell Factor; D019009:Proto-Oncogene Proteins c-kit
keywords: c-kit receptor; signal transduction; targeted therapy; tumor