title: Synthesis and characterization of poly(glycerol-co-sebacate-co-ε-caprolactone) elastomers.
abstract: In this study, poly(glycerol-co-sebacate-co-ε-caprolactone) (PGSCL) elastomers were synthesized for the first time from the respective monomers. The structural analysis of PGSCL elastomers by nuclear magnetic resonance ((1)H-NMR) and Fourier transform infrared spectroscopy (FTIR) revealed that the elastomers have a high number of hydrogen bonds and crosslinks. X-ray diffraction (XRD) and thermal analysis indicated an amorphous state. Differential scanning calorimetry (DSC) analysis showed that the elastomers has a glass transition temperature (T(g)) of -36.96°C. The Young's modulus and compression strength values were calculated as 46.08 MPa and 3.192 MPa, respectively. Calculations based on acid number and end groups analysis revealed a number average molecular weight of 148.15 kDa. Even though the foaming studies conducted by using supercritical CO2 resulted in a porous structure; the obtained morphology tended to disappear after 48 h, leaving small cracks on the surface. This phenomenon was interpreted as an indication of self-healing due to the high number of hydrogen bonds. The PGSCL elastomers synthesized in this study are flexible, robust to compression forces and have self-healing capacity. Thanks to good biocompatibility and poor cell-adhesion properties, the elastomers may find diverse applications where a postoperative adhesion barrier is required.
authors.affiliation: Institute of Science, Bioengineering Division, Hacettepe University, Ankara, Turkey.
authors.forename: H M
authors.initials: HM
authors.lastname: Aydin
authors.affiliation: Chemical Engineering Department and Bioengineering Division, Centre for Bioengineering and Biyomedtek, Hacettepe University, Ankara, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Salimi
authors.affiliation: Institute of Science, Bioengineering Division, Hacettepe University, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Yilmaz
authors.affiliation: Biology Department, Kirikkale University, Yahsihan, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Turk
authors.affiliation: Institute of Science, Nanotechnology and Nanomedicine Division, Hacettepe University, Ankara, Turkey.
authors.forename: Z M O
authors.initials: ZM
authors.lastname: Rzayev
authors.affiliation: Institute of Science, Bioengineering Division, Hacettepe University, Ankara, Turkey.|Chemical Engineering Department and Bioengineering Division, Centre for Bioengineering and Biyomedtek, Hacettepe University, Ankara, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Pişkin
mesh_terms: D002152:Calorimetry, Differential Scanning; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D019245:Compressive Strength / Q000187:drug effects; D003651:Decanoates / Q000138:chemical synthesis* / Q000737:chemistry* / Q000633:toxicity; D020724:Elastomers / Q000138:chemical synthesis* / Q000737:chemistry*; D005990:Glycerol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008970:Molecular Weight; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry* / Q000633:toxicity; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D003651:Decanoates; D020724:Elastomers; D011108:Polymers; C469892:poly(glycerol-sebacate); D005990:Glycerol
keywords: elastomers; glycerol; sebacic acid; self-healing; supercritical CO2; ε-caprolactone