title: Successful treatment of recurrent pediatric inflammatory myofibroblastic tumor in a single patient with a novel chemotherapeutic regimen containing celecoxib.
abstract: Inflammatory myofibroblastic tumors are rare tumors characterized as low-to-intermediate grade sarcomas. This is a case of a 7-year-old male with a 5-cm lung mass, which recurred 11 months after complete resection. The recurrence manifested as multifocal metastatic disease involving the ipsilateral parietal and visceral pleura. A novel chemotherapeutic regimen, which included vincristine, ifosfamide, doxorubicin, and celecoxib was utilized for the disease recurrence. The patient had complete and durable remission of the disease and has been disease-free for >4 years. This novel regimen including a cyclooxygenase 2 inhibitor may be an effective regimen for metastatic inflammatory myofibroblastic tumors.
authors.affiliation: Department of General Surgery, Mayo Clinic, Rochester, MN, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Johnson
authors.forename: David M
authors.initials: DM
authors.lastname: Notrica
authors.forename: David
authors.initials: D
authors.lastname: Carpentieri
authors.forename: Dawn
authors.initials: D
authors.lastname: Jaroszewski
authors.forename: Michael M
authors.initials: MM
authors.lastname: Henry
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068579:Celecoxib; D002648:Child; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D011720:Pyrazoles / Q000008:administration & dosage; D012509:Sarcoma / Q000188:drug therapy*; D013449:Sulfonamides / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D011720:Pyrazoles; D013449:Sulfonamides; D014750:Vincristine; D000068579:Celecoxib; D007069:Ifosfamide