title: Community-acquired CTX-M-15-type ESBL-producing Escherichia coli meningitis: a case report and literature review.
abstract: In this report, a case of community-acquired acute bacterial meningitis (CA-ABM) caused by CTX-M-15-producing Escherichia coli in an elderly male patient was presented in the light of literature. Cultures of cerebrospinal fluid, blood, ear discharge, and stool samples yielded CTX-M-15-producing E. coli in-vitro, which was resistant to the extended-spectrum cephalosporins and ciprofloxacin and susceptible to imipenem, meropenem and amikacin. Meningitis was treated with parenteral meropenem plus parenteral and intraventricular amikacin administration. Since bacterial meningitis is a life-threatening infection, empiric antibiotic therapy with carbapenem can be started before the culture results are obtained, mainly in areas where the ESBL epidemiology is well known.
authors.affiliation: Department of Infectious Diseases and Clinical Bacteriology, Cumhuriyet University, Sivas, Turkey. nelaldi61@yahoo.com
authors.forename: Nazif
authors.initials: N
authors.lastname: Elaldi
authors.forename: Mustafa Gokhan
authors.initials: MG
authors.lastname: Gozel
authors.forename: Fetiye
authors.initials: F
authors.lastname: Kolayli
authors.forename: Aynur
authors.initials: A
authors.lastname: Engin
authors.forename: Cem
authors.initials: C
authors.lastname: Celik
authors.forename: Mustafa Zahir
authors.initials: MZ
authors.lastname: Bakici
authors.forename: Haluk
authors.initials: H
authors.lastname: Vahaboglu
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001769:Blood / Q000382:microbiology; D002555:Cerebrospinal Fluid / Q000382:microbiology; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology*; D004926:Escherichia coli / Q000201:enzymology* / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D006801:Humans; D008297:Male; D020814:Meningitis, Escherichia coli / Q000188:drug therapy / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D010034:Otitis Media with Effusion / Q000382:microbiology; D016896:Treatment Outcome; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000378:metabolism*; D047090:beta-Lactams / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases