title: Primary extraosseous intradural spinal Ewing's sarcoma: report of two cases.
abstract: Two cases of primary extraosseous intradural spinal Ewing's sarcoma are reported with a review of the current literature. This rare neoplasm shares features with cerebral primitive neuroectodermal tumors, complicating a correct diagnosis. Gross total resection seems to be the main treatment, although adjuvant therapies could improve the prognosis. In case 1, a 56-year-old man presented with cauda equina syndrome. MRI showed an intradural tumor from L4 to S2. An emergency laminectomy was performed with gross total resection of a hemorrhagic tumor, followed by adjuvant treatment. In the second case, a 25-year-old female developed leg and lumbar pain. MRI study identified a homogeneously enhancing intradural mass at the L2-L3 level. A laminoplasty was performed, followed by tumor resection; no adjuvant treatment was administered afterwards. Immunohistochemical workup confirmed the diagnosis of Ewing's sarcoma in both cases.
authors.affiliation: Department of Neurological Surgery, Hospital Universitario La Fe, Área Administrativa 5E, c/Bulevar Sur, s/n, 46026, Valencia, Spain. gpancucci@gmail.com
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pancucci
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Simal-Julian
authors.forename: Estela
authors.initials: E
authors.lastname: Plaza-Ramirez
authors.forename: Raul
authors.initials: R
authors.lastname: García-Marcos
authors.forename: Empar
authors.initials: E
authors.lastname: Mayordomo-Aranda
authors.forename: Carlos
authors.initials: C
authors.lastname: Botella-Asunción
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006801:Humans; D007796:Laminectomy / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D018242:Neuroectodermal Tumors, Primitive / Q000473:pathology / Q000601:surgery*; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome