title: [DAZL gene polymorphisms and astheno-teratozoospermia].
abstract: OBJECTIVE
  To investigate the association between single nucleotide polymorphism (SNP) of the DZAL gene in infertile Han Chinese males with astheno-teratozoospermia.
  
  
  METHODS
  We collected semen samples from 173 infertile Han Chinese men with astheno-teratozoospermia (case group) and 175 age-matched normal male volunteers (control group) for semen routine and morphological analyses. We obtained genomic DNA, genotyped the polymorphisms of the DAZL gene A260G and A386G via the Sequenom MassARRAY system, and compared the frequencies of the genotypes between the case and control groups.
  
  
  RESULTS
  The AA nucleotide variant was found in the A260G and A386G polymorphisms of the DZAL gene in both the cases and controls, but the heterozygous AG variant in neither.
  
  
  CONCLUSIONS
  The A260G and A386G polymorphisms of the DAZL gene are not correlated with astheno-teratozoospermia-induced male infertility in the Han Chinese population, and therefore could not be considered as molecular markers of male infertility.
authors.affiliation: Department of Urology, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Lu-Wei
authors.initials: LW
authors.lastname: Ye
authors.forename: Qing-Feng
authors.initials: QF
authors.lastname: Yu
authors.forename: Xue-Xi
authors.initials: XX
authors.lastname: Yang
authors.forename: Jing-Ping
authors.initials: JP
authors.lastname: Li
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Wu
authors.forename: Yong-Hai
authors.initials: YH
authors.lastname: Zhang
authors.forename: Xiang-Ming
authors.initials: XM
authors.lastname: Mao
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005838:Genotype; D006801:Humans; D007248:Infertility, Male / Q000235:genetics; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D016601:RNA-Binding Proteins / Q000235:genetics*
chemical_list: C101358:DAZL protein, human; D016601:RNA-Binding Proteins