title: Evaluation of the immune response of male and female rats vaccinated with cDNA encoding a cysteine proteinase of Fasciola hepatica (FhPcW1).
abstract: Not only do males and females of many species vary in their responses to certain parasitic infections, but also to treatments such as vaccines. However, there are very few studies investigating differences among sexes following vaccination and infection. Here we demonstrate that female Sprague-Dawley rats vaccinated with cDNA encoding a recently discovered cysteine proteinase of Fasciola hepatica (FhPcW1) develop considerably lower liver fluke burdens after F. hepatica infection than their male counterparts. This is accompanied by differences in the course of their immune responses which involve different eosinophil and monocyte responses throughout the study as well as humoral responses. It is evident that host gender influences the outcome of parasitic infections after vaccination and research on both sexes should be considered when developing new treatments against parasites.
authors.affiliation: Department of Molecular Biology, Laboratory of Molecular Parasitology, W. Stefański Institute of Parasitology, Polish Academy of Sciences, 51/55 Twarda St., 00-818, Warsaw, Poland. a.wesolowska@twarda.pan.pl
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wesołowska
authors.forename: Luke J
authors.initials: LJ
authors.lastname: Norbury
authors.forename: Kamil
authors.initials: K
authors.lastname: Januszkiewicz
authors.forename: Luiza
authors.initials: L
authors.lastname: Jedlina
authors.forename: Sławomir
authors.initials: S
authors.lastname: Jaros
authors.forename: Anna
authors.initials: A
authors.lastname: Zawistowska-Deniziak
authors.forename: Wojciech
authors.initials: W
authors.lastname: Zygner
authors.forename: Halina
authors.initials: H
authors.lastname: Wędrychowicz
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth; D057056:Cysteine Proteases / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D018076:DNA, Complementary / Q000008:administration & dosage* / Q000235:genetics; D004804:Eosinophils / Q000276:immunology; D005210:Fasciola hepatica / Q000201:enzymology / Q000276:immunology*; D005211:Fascioliasis / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control*; D005260:Female; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D016896:Treatment Outcome; D014611:Vaccination; D014612:Vaccines / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology
chemical_list: D000909:Antibodies, Helminth; D018076:DNA, Complementary; D014612:Vaccines; D057056:Cysteine Proteases