title: New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia.
abstract: The MLLT10 gene, located at 10p13, is a known partner of MLL and PICALM in specific leukemic fusions generated from recurrent 11q23 and 11q14 chromosome translocations. Deep sequencing recently identified NAP1L1/12q21 as another MLLT10 partner in T-cell acute lymphoblastic leukemia (T-ALL). In pediatric T-ALL, we have identified 2 RNA processing genes, that is, HNRNPH1/5q35 and DDX3X/Xp11.3 as new MLLT10 fusion partners. Gene expression profile signatures of the HNRNPH1- and DDX3X-MLLT10 fusions placed them in the HOXA subgroup. Remarkably, they were highly similar only to PICALM-MLLT10-positive cases. The present study showed MLLT10 promiscuity in pediatric T-ALL and identified a specific MLLT10 signature within the HOXA subgroup.
authors.affiliation: Hematology and Bone Marrow Transplantation Unit, University of Perugia, Perugia, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Brandimarte
authors.forename: Valentina
authors.initials: V
authors.lastname: Pierini
authors.forename: Danika
authors.initials: D
authors.lastname: Di Giacomo
authors.forename: Chiara
authors.initials: C
authors.lastname: Borga
authors.forename: Filomena
authors.initials: F
authors.lastname: Nozza
authors.forename: Paolo
authors.initials: P
authors.lastname: Gorello
authors.forename: Marco
authors.initials: M
authors.lastname: Giordan
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cazzaniga
authors.forename: Geertruy
authors.initials: G
authors.lastname: Te Kronnie
authors.forename: Roberta
authors.initials: R
authors.lastname: La Starza
authors.forename: Cristina
authors.initials: C
authors.lastname: Mecucci
mesh_terms: D002648:Child; D053487:DEAD-box RNA Helicases / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014157:Transcription Factors / Q000235:genetics*; D059467:Transcriptome; D014178:Translocation, Genetic
chemical_list: C092513:MLLT10 protein, human; D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors; C119332:DDX3X protein, human; D053487:DEAD-box RNA Helicases