title: Challenges in the development of heteromer-GPCR-based drugs.
abstract: G-protein-coupled receptors are targets of a variety of diseases. Drug screening has been classically performed assuming the occurrence of monomeric receptors. As more and more receptor heteromers are identified, the challenge is now to develop screening assays to select heteromer-specific drugs. These drugs may, for instance, be able to interact preferentially with prerather than with postsynaptic receptors. Heteromer-based drug discovery opens new perspectives in both Academic pursuits and for the Pharmaceutical industry.
authors.affiliation: Applied Medical Research Center (CIMA), University of Navarra, Pamplona, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Franco
authors.forename: Eva
authors.initials: E
authors.lastname: Martínez-Pinilla
authors.forename: Ana
authors.initials: A
authors.lastname: Ricobaraza
authors.forename: Peter J
authors.initials: PJ
authors.lastname: McCormick
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D055808:Drug Discovery; D006801:Humans; D058990:Molecular Targeted Therapy; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D055503:Protein Multimerization; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D004364:Pharmaceutical Preparations; D043562:Receptors, G-Protein-Coupled