title: Influence of prophylactic neck dissection on rate of retreatment for papillary thyroid carcinoma.
abstract: BACKGROUND
  Prophylactic neck dissection (PND) for papillary thyroid cancer is controversial. The objective of this study was to analyze the influence of PND on the rate of retreatment.
  
  
  METHODS
  In this retrospective case-control study, papillary thyroid carcinomas >10 mm without ultrasonographic evidence of nodal disease (cN0) were treated with total thyroidectomy (TT) or TT with bilateral central compartment PND. All received postoperative radioactive iodine ((131)I) and were followed for at least 1 year. We compared the rate of retreatment (surgery or (131)I).
  
  
  RESULTS
  Altogether, 246 patients (mean age 46 years, 78 % women) underwent TT (n = 91) or TT + PND (n = 155). The groups were similar in age, sex, tumor size, and follow-up (median 6.3 years) (p > 0.05). Overall, 11 (12 %) of the patients in the TT group underwent reoperation in the central compartment for recurrence versus 3 (2 %) in the TT + PND group (p < 0.001). There were 1.18 administrations of (131)I for the TT group versus 1.08 for the TT + PND group (p = 0.08). The average cumulative dose of (131)I was 3.9 ± 1.8 GBq for the TT group and 3.8 ± 1.3 GBq for the TT + PND group (p = 0.52). Actuarial (Kaplan-Meier) 5-year retreatment rates were 14.7 % in the TT group and 6.5 % in the TT + PND group (p = 0.01, log-rank). The rate of permanent recurrent nerve paralysis was 2 % for the TT group and 1 % for the TT + PND group (p = 0.98). The rates of permanent hypoparathyroidism were 7 versus 3 %, respectively (p = 0.12).
  
  
  CONCLUSIONS
  Five-year retreatment rates were lower in patients treated with PND, with no added permanent morbidity.
authors.affiliation: Department of Head and Neck Oncology, Thyroid Surgery Unit, Institut Gustave Roussy and Paris-Sud University, 114, rue Edouard Vaillant, 94805 Villejuif Cedex, France. dana.hartl@igr.fr
authors.forename: Dana M
authors.initials: DM
authors.lastname: Hartl
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Mamelle
authors.forename: Isabelle
authors.initials: I
authors.lastname: Borget
authors.forename: Sophie
authors.initials: S
authors.lastname: Leboulleux
authors.forename: Haïtham
authors.initials: H
authors.lastname: Mirghani
authors.forename: Martin
authors.initials: M
authors.lastname: Schlumberger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000601:surgery*; D002291:Carcinoma, Papillary; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D019233:Retreatment / Q000706:statistics & numerical data; D012189:Retrospective Studies; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000601:surgery*; D013965:Thyroidectomy; D055815:Young Adult