title: Predictors of locoregional recurrence in T1-2N0 tongue cancer patients.
abstract: Locoregional recurrence of oral tongue squamous cell carcinoma (OTSCC) has been considered a poor prognostic entity in terms of survival rate. The purpose of this study was to evaluate the incidence of locoregional recurrence and to identify significant risk factors for locoregional recurrence in early-stage OTSCC. We retrospectively reviewed the records of 58 patients who underwent radical surgery for T1-2N0 OTSCC. The local recurrence and regional recurrence rates were 10.3 % (6/58 patients) and 15.5 % (9/58 patients) in this study, respectively. The survival rate of patients with local recurrence was 66.7 %, which was significantly lower than that (96.2 %) of patients without local recurrence, whereas the survival rates of patients with or without regional recurrence were not significantly difference. Pattern of invasion (POI), neoadjuvant chemotherapy (NAC) and the status of the surgical margin were identified as factors influencing local recurrence. In particular, the status of the deep surgical margin was a high potential independent risk factor. The deep surgical margin was resected closely in many NAC-treated cases, suggesting that NAC may lead to local recurrence and a poor outcome. No efficacy of NAC was observed, suggesting that the standard treatment for early OTSCC is surgery alone.
authors.affiliation: Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan, syana@nagasaki-u.ac.jp.
authors.forename: Souichi
authors.initials: S
authors.lastname: Yanamoto
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Yamada
authors.forename: Hidenori
authors.initials: H
authors.lastname: Takahashi
authors.forename: Goro
authors.initials: G
authors.lastname: Kawasaki
authors.forename: Hisazumi
authors.initials: H
authors.lastname: Ikeda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shiraishi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Fujita
authors.forename: Tohru
authors.initials: T
authors.lastname: Ikeda
authors.forename: Izumi
authors.initials: I
authors.lastname: Asahina
authors.forename: Masahiro
authors.initials: M
authors.lastname: Umeda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D012044:Regression Analysis; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome