title: [Nicotinic acetylcholine receptor in Alzheimer's disease].
abstract: Nicotinic acetylcholine receptor (nAChR) mediates pleiotropic actions in brain not only for nicotinic neurotransmission but also glutamatergic, dopaminergic, norepinephrinergic, GABAergic, and serotonergic transmissions, especially through allosteric potentiating ligand (APL) action. Because nAChR is rich in thalamus, the direct stimulation of nAChR through APL action is expected to show increasing function of cerebral cortex and limbic system through thalamic activation. In fact, a choline esterase inhibitor with this APL action such as galantamine exerts both cognitive and affective improvements which is called dual benefit for Alzheimer's disease patients.
authors.affiliation: Department of Neurology, Okayama University Medical School.
authors.forename: Koji
authors.initials: K
authors.lastname: Abe
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism*; D005702:Galantamine / Q000494:pharmacology; D006801:Humans; D011978:Receptors, Nicotinic / Q000145:classification / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects; D013788:Thalamus / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D011978:Receptors, Nicotinic; D005702:Galantamine