title: The utility of surgical lung biopsy in cancer patients with acute respiratory distress syndrome.
abstract: BACKGROUND
  This retrospective study evaluated the utility and safety of surgical lung biopsy (SLB) in cancer patients with acute respiratory distress syndrome (ARDS).
  
  
  METHODS
  All cases of critically ill patients with cancer and diagnosed with ARDS who underwent SLB in a tertiary care hospital from January 2002 to July 2009 were reviewed. Clinical data including patient baseline characteristics, surgical complications, pathological findings, treatment alterations, and survival outcomes were retrospectively collected and analyzed.
  
  
  RESULTS
  A total of 16 critically ill patients with cancer diagnosed with ARDS who underwent SLB were enrolled. The meantime from ARDS onset to SLB was 3.0 ± 1.5 days. All SLB specimens offered a pathological diagnosis, and specific diagnoses were made in 9 of 16 patients. Biopsy findings resulted in a change in therapy in 11 of 16 patients. Overall, the SLB surgical complication rate was 19% (3/16). SLB did not directly cause the observed operative mortality. The ICU mortality rate was 38% (6/16). Patients who switched therapies after SLB had a trend toward decreased mortality than patients without a change in therapy (27% versus 60%; P = 0.299).
  
  
  CONCLUSIONS
  In selected critically ill cancer patients with ARDS, SLB had a high diagnostic yield rate and an acceptable surgical complication rate.
authors.forename: Chih-Hao
authors.initials: CH
authors.lastname: Chang
authors.forename: Kuo-Chin
authors.initials: KC
authors.lastname: Kao
authors.forename: Han-Chung
authors.initials: HC
authors.lastname: Hu
authors.forename: Chen-Yiu
authors.initials: CY
authors.lastname: Hung
authors.forename: Li-Fu
authors.initials: LF
authors.lastname: Li
authors.forename: Ching-Yang
authors.initials: CY
authors.lastname: Wu
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Wang
authors.forename: Jui-Ying
authors.initials: JY
authors.lastname: Fu
authors.forename: Chung-Chi
authors.initials: CC
authors.lastname: Huang
authors.forename: Ning-Hung
authors.initials: NH
authors.lastname: Chen
authors.forename: Cheng-Ta
authors.initials: CT
authors.lastname: Yang
authors.forename: Ying-Huang
authors.initials: YH
authors.lastname: Tsai
mesh_terms: D001706:Biopsy / Q000706:statistics & numerical data*; D016638:Critical Illness; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000175:diagnosis; D013510:Pulmonary Surgical Procedures / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000150:complications*; D012189:Retrospective Studies