title: Key role of lipids in heat stress management.
abstract: Heat stress is a common and, therefore, an important environmental impact on cells and organisms. While much attention has been paid to severe heat stress, moderate temperature elevations are also important. Here we discuss temperature sensing and how responses to heat stress are not necessarily dependent on denatured proteins. Indeed, it is clear that membrane lipids have a pivotal function. Details of membrane lipid changes and the associated production of signalling metabolites are described and suggestions made as to how the interconnected signalling network could be modified for helpful intervention in disease.
authors.affiliation: Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, H-6701 Szeged, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Balogh
authors.forename: Mária
authors.initials: M
authors.lastname: Péter
authors.forename: Attila
authors.initials: A
authors.lastname: Glatz
authors.forename: Imre
authors.initials: I
authors.lastname: Gombos
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Török
authors.forename: Ibolya
authors.initials: I
authors.lastname: Horváth
authors.forename: John L
authors.initials: JL
authors.lastname: Harwood
authors.forename: László
authors.initials: L
authors.lastname: Vígh
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D018869:Heat-Shock Response; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology; D015398:Signal Transduction
chemical_list: D008055:Lipids; D008565:Membrane Proteins