title: CD1d expression as a prognostic marker for chronic lymphocytic leukemia.
abstract: We analyzed the expression of CD1d, an antigen-presenting molecule, on peripheral blood leukemic cells of cases of chronic lymphocytic leukemia (CLL) by flow cytometry. We demonstrated variable expression of CD1d on leukemic lymphocytes and an association between high expression of CD1d with shorter time to treatment and overall survival of patients. CD1d was positively associated with CD38 expression, but not with unmutated heavy chain variable (VH) mutational status or adverse cytogenetics of leukemic lymphocytes. Our findings support that CD1d expression is a prognostic marker for CLL.
authors.affiliation: Hematology Department, University Hospital of Alexandroupolis , Alexandroupolis , Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Anastasiadis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kotsianidis
authors.forename: Vasileios
authors.initials: V
authors.lastname: Papadopoulos
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Spanoudakis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Margaritis
authors.forename: Anna
authors.initials: A
authors.lastname: Christoforidou
authors.forename: Stamatoula
authors.initials: S
authors.lastname: Gouliamtzi
authors.forename: Costas
authors.initials: C
authors.lastname: Tsatalas
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055610:Antigens, CD1d / Q000378:metabolism*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002869:Chromosome Aberrations; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D055610:Antigens, CD1d; D014408:Biomarkers, Tumor; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D051997:ADP-ribosyl Cyclase 1