title: Parathyroid hormone, vitamin D levels and urine albumin excretion in older persons: the 2011 Korea National Health and Nutrition Examination Survey (KNHANES).
abstract: OBJECTIVE
  Persistent elevation of urinary albumin excretion (UAE), even within normal range, is an independent predictor for cardiovascular disease. Accumulating research suggests that low levels of vitamin D and high levels of parathyroid hormone (PTH) also increase cardiovascular disease risk. This study is intended to investigate the relationship between PTH, vitamin D levels and UAE.
  
  
  METHODS
  We examined 2897 adults aged 50 and above, participating in the second year of the fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2). Anthropometric and laboratory measurements were performed. Elevated UAE was defined as spot urinary albumin creatinine ratio equal or above 10.
  
  
  RESULTS
  The proportion of elevated UAE (21·8%, 23·2%, 23·2%, 31·8%; P for trend = 0·002) rose with increasing quartiles of PTH. The odds ratio for elevated UAE in the highest quartile of PTH was 72% higher than the lowest quartile group. There was no relationship between vitamin D and elevated UAE.
  
  
  CONCLUSIONS
  Elevated PTH levels are associated with elevated UAE in Korean adults aged 50 and above. Additional studies are needed to clarify this relationship.
authors.affiliation: Department of Family Medicine, Daegu Medical Center, Daegu, South Korea.
authors.forename: Hyun-Woo
authors.initials: HW
authors.lastname: Kim
authors.forename: Hyunkyoung
authors.initials: H
authors.lastname: Park
authors.forename: Kyung Hwan
authors.initials: KH
authors.lastname: Cho
authors.forename: Kyungdo
authors.initials: K
authors.lastname: Han
authors.forename: Byung-Joon
authors.initials: BJ
authors.lastname: Ko
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000378:metabolism*; D000419:Albuminuria; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D014807:Vitamin D / Q000097:blood*
chemical_list: D000418:Albumins; D010281:Parathyroid Hormone; D014807:Vitamin D