title: Postnatal weight gain in preterm infants with severe bronchopulmonary dysplasia.
abstract: OBJECTIVE
  To characterize postnatal growth failure (PGF), defined as weight < 10th percentile for postmenstrual age (PMA) in preterm (≤ 27 weeks' gestation) infants with severe bronchopulmonary dysplasia (sBPD) at specified time points during hospitalization, and to compare these in subgroups of infants who died/underwent tracheostomy and others.
  
  
  METHODS
  Retrospective review of data from the multicenter Children's Hospital Neonatal Database (CHND).
  
  
  RESULTS
  Our cohort (n = 375) had a mean ± standard deviation gestation of 25 ± 1.2 weeks and birth weight of 744 ± 196 g. At birth, 20% of infants were small for gestational age (SGA); age at referral to the CHND neonatal intensive care unit (NICU) was 46 ± 50 days. PGF rates at admission and at 36, 40, 44, and 48 weeks' PMA were 33, 53, 67, 66, and 79% of infants, respectively. Tube feedings were administered to > 70% and parenteral nutrition to a third of infants between 36 and 44 weeks' PMA. At discharge, 34% of infants required tube feedings and 50% had PGF. A significantly greater (38 versus 17%) proportion of infants who died/underwent tracheostomy (n = 69) were SGA, compared with those who did not (n = 306; p < 0.01).
  
  
  CONCLUSIONS
  Infants with sBPD commonly had progressive PGF during their NICU hospitalization. Fetal growth restriction may be a marker of adverse outcomes in this population.
authors.affiliation: Department of Pediatrics, Wayne State University, Children's Hospital of Michigan, Detroit, Michigan.
authors.forename: Girija
authors.initials: G
authors.lastname: Natarajan
authors.affiliation: Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas.
authors.forename: Yvette R
authors.initials: YR
authors.lastname: Johnson
authors.affiliation: Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Beverly
authors.initials: B
authors.lastname: Brozanski
authors.affiliation: Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
authors.forename: Kathryn N
authors.initials: KN
authors.lastname: Farrow
authors.affiliation: Childrens' Hospital Association, Overland Park, Kansas.
authors.forename: Isabella
authors.initials: I
authors.lastname: Zaniletti
authors.affiliation: Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Padula
authors.affiliation: Children's Hospital Oakland and Research Center, Oakland, California.
authors.forename: Jeanette M
authors.initials: JM
authors.lastname: Asselin
authors.affiliation: Children's Hospital Oakland and Research Center, Oakland, California.
authors.forename: David J
authors.initials: DJ
authors.lastname: Durand
authors.affiliation: Department of Pediatrics, George Washington University School of Medicine, Washington, District of Columbia.
authors.forename: Billie L
authors.initials: BL
authors.lastname: Short
authors.affiliation: Department of Pediatrics, University of Missouri School of Medicine, Kansas City, Missouri.
authors.forename: Eugenia K
authors.initials: EK
authors.lastname: Pallotto
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: Francine D
authors.initials: FD
authors.lastname: Dykes
authors.affiliation: Department of Pediatrics and Center for Perinatal Research, Division of Neonatology; Columbus, Ohio.
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Reber
authors.affiliation: Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Jacquelyn R
authors.initials: JR
authors.lastname: Evans
authors.affiliation: Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
authors.forename: Karna
authors.initials: K
authors.lastname: Murthy
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006130:Growth Disorders / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D012189:Retrospective Studies; D014139:Tracheostomy; D015430:Weight Gain