title: The role of counselling and other factors in compliance of postmenopausal osteoporotic patients to alendronate 70 therapy.
abstract: BACKGROUND
  The aim of the study was to assess the role of patient counselling, nurse assistance and effects of biochemical examinations in adherence of women with postmenopausal osteoporosis to alendronate 70 administration over 12 months of therapy.
  
  
  METHODS
  Compliance and persistence to alendronate 70 therapy were assessed in a prospective study of 123 postmenopausal women, followed up for one year. The patients were divided into 4 groups (controls, counselled group, biochemical group and nurse assisted group) with monitoring every 6 months; in the nurse assisted group, additional phone contacts were made after 3 and 9 months of treatment. After 12 months, compliance and persistence were analysed. The medication possession ratio (MPR) was regarded as optimal when its value exceeded 80%.
  
  
  RESULTS
  The compliance to alendronate 70 therapy was 54.03% in the control group and the mean persistence with medication was 197 days. The MPR above 80% was observed in 37.5%, and, after 1 year, 43.75% of patients were found persistent with the therapy. In the remaining groups, both compliance and persistence were higher but not statistically significantly, compared to the control group. Neither patient's age, education, diet, nor physical activity influenced the compliance with prescribed therapy. The most common reason to discontinue therapy was either its side effects or smoking.
  
  
  CONCLUSIONS
  The obtained results suggest that better adherence with medical recommendations is observed in patients who receive additional attention, e.g. counselling, biochemical tests or nursing care. The critical elements for therapy discontinuation were side effects and smoking.
authors.affiliation: Department of Endocrine Disorders and Bone Metabolism, Medical University of Lodz, Poland ; Outpatient Clinic of Osteoporosis, Lodz, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Sewerynek
authors.forename: Hanna
authors.initials: H
authors.lastname: Horst-Sikorska
authors.forename: Wioletta
authors.initials: W
authors.lastname: Stępień-Kłos
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Antkowiak
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Janik
authors.forename: Karol
authors.initials: K
authors.lastname: Cieślak
authors.forename: Michalina
authors.initials: M
authors.lastname: Marcinkowska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Cegłowska
authors.forename: Michał
authors.initials: M
authors.lastname: Stuss
keywords: adherence; alendronate; persistence; reasons for therapy discontinuation