title: Activation and involvement of the lateral-posterior nucleus of the thalamus after a single generalized tonic-clonic seizure.
abstract: The lateral-posterior thalamic nuclei (LP) have been shown to play an important role in controlling epileptic activity. In addition, thalamic atrophy and neuronal loss have been observed in epilepsy. The objective of this study was to investigate whether lateral-posterior neuronal activation may be observed shortly after a single generalized seizure in rats submitted to the pilocarpine model of epilepsy. The results showed an increased lateral-posterior activation as soon as the seizure occurred, suggesting that neuronal loss in the thalamus is not only the consequence of chronic epilepsy.
authors.affiliation: Departamento de Neurologia Experimental, Universidade Federal de São Paulo/Escola Paulista de Medicina, São Paulo, Brazil. elizasonoda@gmail.com
authors.forename: Eliza Yumi de Freitas
authors.initials: EY
authors.lastname: Sonoda
authors.forename: Roberta Monterazzo
authors.initials: RM
authors.lastname: Cysneiros
authors.forename: Ricardo Mario
authors.initials: RM
authors.lastname: Arida
authors.forename: Esper Abrão
authors.initials: EA
authors.lastname: Cavalheiro
authors.forename: Fulvio Alexandre
authors.initials: FA
authors.lastname: Scorza
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004829:Epilepsy, Generalized / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D018721:Muscarinic Agonists / Q000633:toxicity; D009474:Neurons / Q000378:metabolism; D010862:Pilocarpine / Q000633:toxicity; D020656:Posterior Thalamic Nuclei / Q000187:drug effects / Q000473:pathology*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018721:Muscarinic Agonists; D016760:Proto-Oncogene Proteins c-fos; D010862:Pilocarpine