title: Mutational analysis of SKP2 and P27 in Chinese Han women with premature ovarian failure.
abstract: P27 and SKP2, a major regulator of P27, play a crucial role in ovarian function in mice. Both P27-deficient and SKP2-deficient female mice develop premature ovarian failure (POF). The coding regions of SKP2 and P27 were examined in 200 Chinese women with POF and 200 control volunteers. This study is the first to investigate SKP2 in POF. No plausible pathogenic mutations were detected. The results suggest that mutations in SKP2 and P27 are not common in Chinese Han women with POF.
authors.affiliation: Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan 250021, China.
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Zhao
authors.forename: Deying
authors.initials: D
authors.lastname: Wei
authors.forename: Yulan
authors.initials: Y
authors.lastname: Mu
authors.forename: Yingying
authors.initials: Y
authors.lastname: Qin
authors.forename: Guangyu
authors.initials: G
authors.lastname: Li
authors.forename: Linlin
authors.initials: L
authors.lastname: Cui
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D016649:Primary Ovarian Insufficiency / Q000235:genetics*; D044786:S-Phase Kinase-Associated Proteins / Q000235:genetics*
chemical_list: D044786:S-Phase Kinase-Associated Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27