title: A prospective investigation of fish, meat and cooking-related carcinogens with endometrial cancer incidence.
abstract: BACKGROUND
  There are limited prospective studies of fish and meat intakes with risk of endometrial cancer and findings are inconsistent.
  
  
  METHODS
  We studied associations between fish and meat intakes and endometrial cancer incidence in the large, prospective National Institutes of Health-AARP Diet and Health Study. Intakes of meat mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and benzo(a)pyrene (BaP) were also calculated. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
  
  
  RESULTS
  We observed no associations with endometrial cancer risk comparing the highest to lowest intake quintiles of red (HR=0.91, 95% CI 0.77-1.08), white (0.98, 0.83-1.17), processed meats (1.02, 0.86-1.21) and fish (1.10, 95% CI 0.93-1.29). We also found no associations between meat mutagen intakes and endometrial cancer.
  
  
  CONCLUSIONS
  Our findings do not support an association between meat or fish intakes or meat mutagens and endometrial cancer.
authors.affiliation: Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA. Aremhe2@mail.nih.gov
authors.forename: H
authors.initials: H
authors.lastname: Arem
authors.forename: M J
authors.initials: MJ
authors.lastname: Gunter
authors.forename: A J
authors.initials: AJ
authors.lastname: Cross
authors.forename: A R
authors.initials: AR
authors.lastname: Hollenbeck
authors.forename: R
authors.initials: R
authors.lastname: Sinha
mesh_terms: D000368:Aged; D000818:Animals; D003296:Cooking / Q000706:statistics & numerical data*; D004032:Diet / Q000706:statistics & numerical data*; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005399:Fishes; D005500:Follow-Up Studies; D006801:Humans; D008460:Meat / Q000706:statistics & numerical data*; D008875:Middle Aged; D014481:United States / Q000453:epidemiology