title: A novel vitreous substitute of using a foldable capsular vitreous body injected with polyvinylalcohol hydrogel.
abstract: Hydrogels may be the ideal vitreous substitutes due to their wonderful physical features and biocompatibility. However, their drawbacks, short residence time, and biodegradation in vivo, have led to the fact that none of them have been approved for clinical use. In this study, we developed a novel approach of using a foldable capsular vitreous body (FCVB) injected with polyvinylalcohol (PVA) hydrogel as a vitreous substitute for long-term tamponade. The 3% PVA hydrogel that was cross-linked by gamma irradiation showed good rheological and physical properties and had no toxicity in vitro. After 180 days retention, the 3% PVA hydrogel inside FCVB remained transparent and showed good viscoelasticity without biodegradation and showed good biocompatibility and retina support. This new approach may develop into a valuable tool to improve the stability performance of PVA hydrogel as a vitreous substitute and to extend the application function of FCVB for long-term implantation in vitreous cavity.
authors.affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510060, China.
authors.forename: Songfu
authors.initials: S
authors.lastname: Feng
authors.forename: Han
authors.initials: H
authors.lastname: Chen
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Huang
authors.forename: Xuyuan
authors.initials: X
authors.lastname: Sun
authors.forename: Lian
authors.initials: L
authors.lastname: Zhou
authors.forename: Xiaohe
authors.initials: X
authors.lastname: Lu
authors.forename: Qianying
authors.initials: Q
authors.lastname: Gao
mesh_terms: D000818:Animals; D002386:Cataract / Q000188:drug therapy*; D002478:Cells, Cultured; D016503:Drug Delivery Systems; D004596:Electroretinography; D005123:Eye / Q000187:drug effects* / Q000473:pathology; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage / Q000494:pharmacology*; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D012825:Silicon / Q000737:chemistry; D014821:Vitrectomy; D014822:Vitreous Body / Q000187:drug effects* / Q000473:pathology
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011142:Polyvinyl Alcohol; D006820:Hyaluronic Acid; D012825:Silicon