title: Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor is associated with the favorable clinicopathologic parameters in small intestinal carcinomas.
abstract: OBJECTIVE
  The insulin-like growth factor (IGF) system has been known to play a critical role in tumor development and progression in many human cancers. However, the role of the IGF system in small intestinal carcinoma (SIC) has not been studied yet.
  
  
  METHODS
  We evaluated the expression of IGF1 and IGF1 receptor (IFG1R) in a total of 194 cases of SIC.
  
  
  RESULTS
  IGF1 expression was associated with well/moderate differentiation, better survival, lower pT, lower stage and no lymph node metastasis. IGF1R was more diffusely and strongly expressed in tumors with lower pT and lower stage.
  
  
  CONCLUSIONS
  IGF1 and IGF1R expression is associated with favorable clinicopathologic parameters and may involve early carcinogenesis of SICs. Target therapy for the IGF1R signaling pathway may not have a major therapeutic role in treating SIC.
authors.affiliation: Department of Pathology, Yeungnam University College of Medicine, Daegu 705-717, Korea.
authors.forename: Hyung Chan
authors.initials: HC
authors.lastname: Shin
authors.forename: Young Kyung
authors.initials: YK
authors.lastname: Bae
authors.forename: Mi Jin
authors.initials: MJ
authors.lastname: Gu
authors.forename: Eun Sun
authors.initials: ES
authors.lastname: Jung
authors.forename: Young-Ha
authors.initials: YH
authors.lastname: Oh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D002454:Cell Differentiation; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007414:Intestinal Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D007421:Intestine, Small / Q000737:chemistry* / Q000473:pathology; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D017526:Receptor, IGF Type 1 / Q000032:analysis*; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C583557:IGF1 protein, human; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1