title: Hepcidin as a predictor of disease severity in acute pancreatitis: a single center prospective study.
abstract: OBJECTIVE
  Predicting the severity of acute pancreatitis is limited to clinical, laboratory and radiological risk factors. Hepcidin levels increase in acute inflammation. We aimed to assess the relationship between hepcidin and C-reactive protein (CRP), white blood cells (WBC) and multi-detector computerized tomography (MDCT) in predicting the severity of pancreatitis.
  
  
  METHODS
  We undertook a prospective review of 59 consecutive patients with acute pancreatitis admitted to our clinic. Biochemical values were measured from blood samples taken within 2 hours of admission and from between 2 and 72 hours related to the time of symptom onset.
  
  
  RESULTS
  In predicting severe acute pancreatitis, hepcidin was superior to CRP and WBC (Area Under the Curve (AUC)=0.79, p=0.003; AUC=0.69, p=NS; AUC=0.53, p=NS, respectively).
  
  
  CONCLUSIONS
  In this study, hepcidin was found to be superior to CRP in predicting the severity of pancreatitis.
authors.affiliation: Department of Gastroenterology, Izmir Katip Celebi University, Atatürk Training and Research Hospital, Izmir, Turkey. mahmutarabul@gmail.com
authors.forename: Mahmut
authors.initials: M
authors.lastname: Arabul
authors.forename: Mustafa
authors.initials: M
authors.lastname: Celik
authors.forename: Ozgur
authors.initials: O
authors.lastname: Aslan
authors.forename: Serkan
authors.initials: S
authors.lastname: Torun
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Beyazit
authors.forename: Emrah
authors.initials: E
authors.lastname: Alper
authors.forename: Altay
authors.initials: A
authors.lastname: Kandemir
authors.forename: Belkis
authors.initials: B
authors.lastname: Ünsal
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016009:Chi-Square Distribution; D005260:Female; D064451:Hepcidins; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D010195:Pancreatitis / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D012720:Severity of Illness Index; D013997:Time Factors; D014421:Turkey; D055815:Young Adult
chemical_list: D023181:Antimicrobial Cationic Peptides; D015415:Biomarkers; C578702:HAMP protein, human; D064451:Hepcidins; D002097:C-Reactive Protein