title: Protective effect of lawsone on L-Arginine induced acute pancreatitis in rats.
abstract: The efficacy of lawsone against L-arginine induced acute pancreatitis was determined at 24 h by determination of serum levels of amylase, lipase and proinflammatory cytokines [tumor necrosis factor (TNF)-alpha, C-reactive proteins and interleukin (IL)], pancreatic myeloperoxidase (MPO) activity, lipid peroxidation (thiobarbituric acid reactive substances (TBARS)], nitrate/nitrite levels, and the wet weight/body weight ratio. Lawsone and methylprednisolone treatments significantly attenuated the L-arginine- induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-alpha and IL-6 and significantly lowered pancreatic levels of MPO, TBARS, and nitrate/nitrite. The histoimmunological findings further proved the amelioration of pancreatic injury by lawsone and further proved anti-inflammatory and antioxidant agent property of lawsone.
authors.affiliation: Department of Pharmacology, G. Pulla Reddy College of Pharmacy, Hyderabad, India. sandeepbiradar84@gmail.com
authors.forename: Sandeep
authors.initials: S
authors.lastname: Biradar
authors.forename: B
authors.initials: B
authors.lastname: Veeresh
mesh_terms: D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism; D001120:Arginine / Q000009:adverse effects*; D002097:C-Reactive Protein / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D015850:Interleukin-6 / Q000378:metabolism; D007378:Interleukins / Q000378:metabolism; D008297:Male; D009285:Naphthoquinones / Q000494:pharmacology*; D009504:Neutrophils / Q000378:metabolism; D018384:Oxidative Stress; D010179:Pancreas / Q000378:metabolism; D010195:Pancreatitis / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016207:Cytokines; D004791:Enzyme Inhibitors; D015850:Interleukin-6; D007378:Interleukins; D009285:Naphthoquinones; D017392:Thiobarbituric Acid Reactive Substances; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D001120:Arginine; C005090:lawsone