title: Modeling cell-in-cell structure into its biological significance.
abstract: Although cell-in-cell structure was noted 100 years ago, the molecular mechanisms of 'entering' and the destination of cell-in-cell remain largely unclear. It takes place among the same type of cells (homotypic cell-in-cell) or different types of cells (heterotypic cell-in-cell). Cell-in-cell formation affects both effector cells and their host cells in multiple aspects, while cell-in-cell death is under more intensive investigation. Given that cell-in-cell has an important role in maintaining homeostasis, aberrant cell-in-cell process contributes to the etiopathology in humans. Indeed, cell-in-cell is observed in many pathological processes of human diseases. In this review, we intend to discuss the biological models of cell-in-cell structures under physiological and pathological status.
authors.affiliation: The Institute of Life Sciences, Chinese PLA General Hospital and SCUT, the State Key Laboratory of Kidney Disease, Beijing 100853, China.
authors.forename: M-f
authors.initials: MF
authors.lastname: He
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: X-n
authors.initials: XN
authors.lastname: Wang
mesh_terms: D002459:Cell Fusion; D002467:Cell Nucleus / Q000378:metabolism; D057686:Cell-in-Cell Formation; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000502:physiology; D008954:Models, Biological; D011123:Polyploidy