title: Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy.
abstract: Two new oxanthrone C-glycosides, patientosides A (14) and B (15), together with three known ones (11-13), were isolated from Rumex patientia. Their structures were identified on the basis of spectroscopic methods. The absolute configuration for 14 and 15 were deduced by analysis of their CD spectra and comparison with those of known similar compounds. Compounds 11-15, and 14 known anthraquinones (1-4, 6-10, 16-20) previously isolated from Rumex nepalensis, Rumex hastatus, and endophytic Aspergillus fumigatus, respectively, as well as a commercially available compound rhein (5) were evaluated for their inhibitory effects on IL-6 and extracellular matrix production in mesangial cells.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Yan
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.forename: Lan-Sheng
authors.initials: LS
authors.lastname: Zhang
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Zhou
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Wang
authors.forename: Yong-Xun
authors.initials: YX
authors.lastname: Yang
authors.forename: Yong-Xian
authors.initials: YX
authors.lastname: Cheng
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005109:Extracellular Matrix / Q000187:drug effects* / Q000378:metabolism; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis; D050527:Mesangial Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy*; D031804:Rumex / Q000737:chemistry*; D013329:Structure-Activity Relationship; D000093242:Interleukin-6 Inhibitors
chemical_list: D000880:Anthraquinones; D006027:Glycosides; D015850:Interleukin-6; D009281:Naphthalenes; D000093242:Interleukin-6 Inhibitors; C434025:patientoside A; C434026:patientoside B