title: Interhemispheric asymmetry of olfactory input-dependent neuronal specification in the adult brain.
abstract: The vertebrate brain is anatomically and functionally asymmetric. The left and right cerebral hemispheres harbor neural stem cell niches at the ventricular-subventricular zone (V-SVZ) of the ventricular walls, where new neurons are continuously generated throughout life. However, any interhemispheric asymmetry of neural stem cell niches remains unclear. We performed gene-trap screens in adult zebrafish to identify genes that are differentially expressed in the two hemispheres and found that adult-born neurons expressing the neural zinc-finger protein Myt1 exist predominantly in the left V-SVZ. This lateralization could be reversed by left olfactory sensory deprivation-induced inactivation of Notch signaling. The olfactory behavioral preference for attractive amino acids was also impaired by sensory deprivation of the left olfactory system, but not of the right olfactory system. Our findings suggest that olfactory input generates interhemispheric differences in the fate of adult-born neurons in the zebrafish brain.
authors.affiliation: Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Norihito
authors.initials: N
authors.lastname: Kishimoto
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Asakawa
authors.forename: Romain
authors.initials: R
authors.lastname: Madelaine
authors.forename: Patrick
authors.initials: P
authors.lastname: Blader
authors.forename: Koichi
authors.initials: K
authors.lastname: Kawakami
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Sawamoto
mesh_terms: D000367:Age Factors; D000596:Amino Acids / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D030801:Animals, Genetically Modified; D017115:Catheter Ablation; D002552:Cerebral Ventricles / Q000378:metabolism; D004151:Dipeptides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004848:Epithelium / Q000293:injuries / Q000502:physiology; D007839:Functional Laterality / Q000235:genetics / Q000502:physiology*; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D007276:Injections, Intraventricular; D008124:Locomotion / Q000187:drug effects / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000502:physiology*; D009812:Odorants; D009830:Olfactory Bulb / Q000166:cytology* / Q000502:physiology; D009833:Olfactory Pathways / Q000166:cytology / Q000502:physiology*; D015027:Zebrafish; D029961:Zebrafish Proteins / Q000235:genetics
chemical_list: D000596:Amino Acids; D004151:Dipeptides; D004791:Enzyme Inhibitors; D018840:HSP70 Heat-Shock Proteins; C419410:N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester; D009419:Nerve Tissue Proteins; D029961:Zebrafish Proteins; C098463:dolaisoleucine; D049452:Green Fluorescent Proteins