title: [Advance in studies on effect of paeoniflorin on nervous system].
abstract: Paeoniflorin (PF) is the chief active component of paeonia, with diverse pharmacological actions and wide application. Recently, the effect of PF on nervous system has attracted increasingly more attention. According to current study findings, PF can ameliorate the decline of memory and learning capacities in many dementia model animals, and have effect in protecting the cerebral ischemia injury, treating Parkinson's disease, reliving pain and improving neural synapse plasticity. Thought its mechanism has not been clarified, current findings show that adenosine A1 receptor plays an important role, while M cholinergic receptor, opiate receptor, calcium ion channel and NF-KB may also play a part in paeoniflorin's effect on nervous system.
authors.affiliation: Research Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China.
authors.forename: Zeng-Yao
authors.initials: ZY
authors.lastname: Hu
authors.forename: Lan
authors.initials: L
authors.lastname: Xu
authors.forename: Rong
authors.initials: R
authors.lastname: Yan
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Wen-Xia
authors.initials: WX
authors.lastname: Zhou
authors.forename: Yong-Xiang
authors.initials: YX
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D015220:Calcium Channels / Q000378:metabolism; D005960:Glucosides / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D039821:Monoterpenes; D016328:NF-kappa B / Q000378:metabolism; D009420:Nervous System / Q000187:drug effects* / Q000378:metabolism; D043682:Receptor, Adenosine A1 / Q000378:metabolism; D006027:Glycosides
chemical_list: D001565:Benzoates; D001952:Bridged-Ring Compounds; D015220:Calcium Channels; D005960:Glucosides; D039821:Monoterpenes; D016328:NF-kappa B; D043682:Receptor, Adenosine A1; C015423:peoniflorin; D006027:Glycosides