title: Coniochaetones E-I, new 4H-chromen-4-one derivatives from the Cordyceps-colonizing fungus Fimetariella sp.
abstract: Five new 4H-chromen-4-one derivatives coniochaetones E-I (1-5), along with the known compounds coniochaetones B (6) and A (7) have been isolated from solid cultures of the Cordyceps-colonizing fungus Fimetariella sp. Their structures were elucidated primarily by NMR spectroscopy and the absolute configurations of compounds 1-3 were assigned using the modified Mosher's method. Compound 4 showed weak cytotoxic activity against HeLa cells with IC50 values of 72.8 μM. The co-isolated known compound 6 showed modest inhibitory effects against Aspergilus fumigates, Fusarium oxysporum and Fusarium nivale.
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Lianwu
authors.initials: L
authors.lastname: Deng
authors.forename: Shubing
authors.initials: S
authors.lastname: Niu
authors.forename: Xingzhong
authors.initials: X
authors.lastname: Liu
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
authors.forename: Erwei
authors.initials: E
authors.lastname: Li
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001203:Ascomycota / Q000737:chemistry*; D001230:Aspergillus / Q000187:drug effects; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D032661:Cordyceps; D005670:Fusarium / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D002867:Chromones; C586570:coniochaetone H; C586571:coniochaetone B
keywords: Antifungal activity; Coniochaetone; Cordyceps-colonizing fungus; Cytotoxic activity; Structure elucidation