title: Cephalosporin resistant Escherichia coli from cancer patients in Cairo, Egypt.
abstract: Cephalosporin-resistant Escherichia coli has been increasingly reported worldwide. In this study, 32 cephalosporin resistant E. coli isolates identified from cancer patients in Cairo, Egypt in 2009-2010 were analyzed. Twenty-three were of phylogenetic group D, seven A and one each B1 and B2. By rep-PCR 15 phylogroup D isolates were grouped in four clusters, one with sequence type (ST) 405 and three ST68. Seventeen isolates showed single patterns. blaCTX-M-15 and aac(6')-Ib-cr were the most common resistance determinants. blaOXA-48 and blaVIM were also detected. Multidrug resistant E. coli seriously affects healthcare, especially in immunocompromised hosts, such as cancer patients.
authors.affiliation: Department of Microbiology and Immunology, Faculty of Pharmacy, Helwan University, Main Campus, Helwan, Cairo 11795, Egypt.
authors.forename: Mohammed O
authors.initials: MO
authors.lastname: Abdelaziz
authors.forename: Celestino
authors.initials: C
authors.lastname: Bonura
authors.forename: Aurora
authors.initials: A
authors.lastname: Aleo
authors.forename: Teresa
authors.initials: T
authors.lastname: Fasciana
authors.forename: Cinzia
authors.initials: C
authors.lastname: Calà
authors.forename: Caterina
authors.initials: C
authors.lastname: Mammina
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D004269:DNA, Bacterial / Q000235:genetics; D004534:Egypt; D004926:Escherichia coli / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000382:microbiology*; D005798:Genes, Bacterial; D005838:Genotype; D006801:Humans; D058889:Molecular Typing; D009369:Neoplasms / Q000150:complications*; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004269:DNA, Bacterial; D001618:beta-Lactamases