title: A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.
abstract: We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules.
authors.affiliation: Dipartimento di Studi di Chimica e Tecnologie del Farmaco, Università Sapienza, Piazzale Aldo Moro 5, I-00185 Roma, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Battilocchio
authors.forename: Giovanna
authors.initials: G
authors.lastname: Poce
authors.forename: Salvatore
authors.initials: S
authors.lastname: Alfonso
authors.forename: Giulio Cesare
authors.initials: GC
authors.lastname: Porretta
authors.forename: Sara
authors.initials: S
authors.lastname: Consalvi
authors.forename: Lidia
authors.initials: L
authors.lastname: Sautebin
authors.forename: Simona
authors.initials: S
authors.lastname: Pace
authors.forename: Antonietta
authors.initials: A
authors.lastname: Rossi
authors.forename: Carla
authors.initials: C
authors.lastname: Ghelardini
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Di Cesare Mannelli
authors.forename: Silvia
authors.initials: S
authors.lastname: Schenone
authors.forename: Antonio
authors.initials: A
authors.lastname: Giordani
authors.forename: Luigia
authors.initials: L
authors.lastname: Di Francesco
authors.forename: Paola
authors.initials: P
authors.lastname: Patrignani
authors.forename: Mariangela
authors.initials: M
authors.lastname: Biava
mesh_terms: D000700:Analgesics / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D002460:Cell Line; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D011758:Pyrroles