title: Information theory, gene expression, and combinatorial regulation: a quantitative analysis.
abstract: According to a functional definition of the term "gene", a protein-coding gene corresponds to a polypeptide and, hence, a coding sequence. It is therefore as such not yet present at the DNA level, but assembled from possibly heterogeneous pieces in the course of RNA processing. Assembly and regulation of genes require, thus, information about when and in which quantity specific polypeptides are to be produced. To assess this, we draw upon precise biochemical data. On the basis of our conceptual framework, we also develop formal models for the coordinated expression of specific sets of genes through the interaction of transcripts and mRNAs and with proteins via a precise putative regulatory code. Thus, the nucleotides in transcripts and mRNA are not only arranged into amino acid-coding triplets, but at the same time may participate in regulatory oligomotifs that provide binding sites for specific proteins. We can then quantify and compare product and regulatory information involved in gene expression and regulation.
authors.affiliation: , Leipzig, Germany, jjost@mis.mpg.de.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Jost
authors.forename: Klaus
authors.initials: K
authors.lastname: Scherrer
mesh_terms: D000818:Animals; D002645:Chickens; D019295:Computational Biology / Q000379:methods*; D004247:DNA / Q000737:chemistry; D004331:Drosophila melanogaster; D020869:Gene Expression Profiling / Q000379:methods*; D005786:Gene Expression Regulation; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008962:Models, Theoretical; D012313:RNA / Q000737:chemistry; D012333:RNA, Messenger / Q000378:metabolism; D055542:alpha-Globins / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D055542:alpha-Globins; D012313:RNA; D004247:DNA