title: A microfluidic concentration-gradient droplet array generator for the production of multi-color nanoparticles.
abstract: A microfluidic concentration-gradient droplet array generator (CDrAG) with parallel multi-channels and multi-layers was developed with 64 outlet channels producing 33 droplet gradient concentrations. A droplet production rate of 5 × 10(4) min(-1) was obtained, and the RSD value of droplet diameters in 64 groups is 5.5% (n = 64). Using the concentration gradient droplet array as parallel microreactors, 33 Au/Ag ratio nanoparticles were synthesized. The absorption spectra of the Au/Ag nanoparticles shifted from the spectrum of pure gold to one of pure silver. This demonstrates the CDrAG platform's promising potential to produce specific nanoparticle barcodes for high-throughput screening in chemistry, biology and a broad range of life science applications.
authors.affiliation: Research Center for Analytical Sciences, Northeastern University, Shenyang, 110819, China.
authors.forename: Chun-Guang
authors.initials: CG
authors.lastname: Yang
authors.forename: Zhang-Run
authors.initials: ZR
authors.lastname: Xu
authors.forename: Abraham P
authors.initials: AP
authors.lastname: Lee
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Wang
mesh_terms: D003116:Color; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D004867:Equipment Design; D006046:Gold / Q000737:chemistry*; D057166:High-Throughput Screening Assays / Q000295:instrumentation / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D010316:Particle Size; D012834:Silver / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D004129:Dimethylpolysiloxanes; D012834:Silver; C013830:baysilon; D006046:Gold