title: Correction for misclassification of caries experience in the absence of internal validation data.
abstract: OBJECTIVE
  To quantify the effects of risk factors and/or determinants on disease occurrence, it is important that the risk factors as well as the variable that measures the disease outcome are recorded with the least error as possible. When investigating the factors that influence a binary outcome, a logistic regression model is often fitted under the assumption that the data are collected without error. However, most categorical outcomes (e.g., caries experience) are accompanied by misclassification and this needs to be accounted for. The aim of this research was to adjust for binary outcome misclassification using an external validation study when investigating factors influencing caries experience in schoolchildren.
  
  
  METHODS
  Data from the Signal Tandmobiel(®) study were used. A total of 500 children from the main and 148 from the validation study were included in the analysis. Regression models (with several covariates) for sensitivity and specificity were used to adjust for misclassification in the main data.
  
  
  RESULTS
  The use of sensitivity and specificity modeled as functions of several covariates resulted in a better correction compared to using point estimates of sensitivity and specificity. Age, geographical location of the school to which the child belongs, dentition type, tooth type, and surface type were significantly associated with the prevalence of caries experience.
  
  
  CONCLUSIONS
  Sensitivity and specificity calculated based on an external validation study may resemble those obtained from an internal study if conditioned on a rich set of covariates.
  
  
  CONCLUSIONS
  Main data can be corrected for misclassification using information obtained from an external validation study when a rich set of covariates is recorded during calibration.
authors.affiliation: Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Kapucijnenvoer 35 Blok D, Box 7001, 3000, Leuven, Belgium.
authors.forename: T
authors.initials: T
authors.lastname: Mutsvari
authors.forename: D
authors.initials: D
authors.lastname: Declerck
authors.forename: E
authors.initials: E
authors.lastname: Lesaffre
mesh_terms: D003731:Dental Caries / Q000145:classification*; D006801:Humans