title: Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma.
abstract: Prevalence of neuropathic pain is high after major surgery. However, effective treatment for preventing neuropathic pain is lacking. Here we report that perisurgical treatment of neuroprotectin D1/protectin D1 (NPD1/PD1), derived from docosahexaenoic acid, prevents nerve injury-induced mechanical allodynia and ongoing pain in mice. Intrathecal post-treatment of NPD1/PD1 also effectively reduces established neuropathic pain and produces no apparent signs of analgesic tolerance. Mechanistically, NPD1/PD1 treatment blocks nerve injury-induced long-term potentiation, glial reaction, and inflammatory responses, and reverses synaptic plasticity in the spinal cord. Thus, NPD1/PD1 and related mimetics might serve as a new class of analgesics for preventing and treating neuropathic pain.
authors.affiliation: Pain Signaling and Plasticity Laboratory, Department of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, NC; Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Zhen-Zhong
authors.initials: ZZ
authors.lastname: Xu
authors.forename: Xing-Jun
authors.initials: XJ
authors.lastname: Liu
authors.forename: Temugin
authors.initials: T
authors.lastname: Berta
authors.forename: Chul-Kyu
authors.initials: CK
authors.lastname: Park
authors.forename: Ning
authors.initials: N
authors.lastname: Lü
authors.forename: Charles N
authors.initials: CN
authors.lastname: Serhan
authors.forename: Ru-Rong
authors.initials: RR
authors.lastname: Ji
mesh_terms: D000818:Animals; D004281:Docosahexaenoic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D009437:Neuralgia / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D010147:Pain Measurement; D059348:Peripheral Nerve Injuries / Q000150:complications* / Q000503:physiopathology; D012584:Sciatic Nerve / Q000293:injuries* / Q000503:physiopathology; D013116:Spinal Cord / Q000187:drug effects
chemical_list: C487679:protectin D1; D004281:Docosahexaenoic Acids