title: Rapid re-infection with soil-transmitted helminths after triple-dose albendazole treatment of school-aged children in Yunnan, People's Republic of China.
abstract: Post-treatment soil-transmitted helminth re-infection patterns were studied as part of a randomized controlled trial among school-aged children from an ethnic minority group in Yunnan province, People's Republic of China. Children with a soil-transmitted helminth infection (N = 194) were randomly assigned to triple-dose albendazole or placebo and their infection status monitored over a 6-month period using the Kato-Katz and Baermann techniques. Baseline prevalence of Trichuris trichiura, Ascaris lumbricoides, hookworm, and Strongyloides stercoralis were 94.5%, 93.3%, 61.3%, and 3.1%, respectively, with more than half of the participants harboring triple-species infections. For the intervention group (N = 99), the 1-month post-treatment cure rates were 96.7%, 91.5%, and 19.6% for hookworm, A. lumbricoides, and T. trichiura, respectively. Egg reduction rates were above 88% for all three species. Rapid re-infection with A. lumbricoides was observed: the prevalence 4 and 6 months post-treatment was 75.8% and 83.8%, respectively. Re-infection with hookworm and T. trichiura was considerably slower.
authors.affiliation: Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
authors.forename: Peiling
authors.initials: P
authors.lastname: Yap
authors.forename: Zun-Wei
authors.initials: ZW
authors.lastname: Du
authors.forename: Fang-Wei
authors.initials: FW
authors.lastname: Wu
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Jiang
authors.forename: Ran
authors.initials: R
authors.lastname: Chen
authors.forename: Xiao-Nong
authors.initials: XN
authors.lastname: Zhou
authors.forename: Jan
authors.initials: J
authors.lastname: Hattendorf
authors.forename: Jürg
authors.initials: J
authors.lastname: Utzinger
authors.forename: Peter
authors.initials: P
authors.lastname: Steinmann
mesh_terms: D015766:Albendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D000723:Ancylostomatoidea; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D001196:Ascariasis / Q000188:drug therapy / Q000453:epidemiology; D017164:Ascaris lumbricoides; D002648:Child; D002681:China / Q000453:epidemiology; D004311:Double-Blind Method; D005243:Feces / Q000469:parasitology; D005260:Female; D006373:Helminthiasis / Q000188:drug therapy* / Q000453:epidemiology; D006725:Hookworm Infections / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D008297:Male; D010270:Parasite Egg Count; D015995:Prevalence; D012987:Soil / Q000469:parasitology; D017171:Strongyloides stercoralis; D013322:Strongyloidiasis / Q000188:drug therapy / Q000453:epidemiology; D016896:Treatment Outcome; D014257:Trichuriasis / Q000188:drug therapy / Q000453:epidemiology; D014258:Trichuris
chemical_list: D000871:Anthelmintics; D012987:Soil; D015766:Albendazole