title: Effect of nutrient supplementation on atopic dermatitis in children: a systematic review of probiotics, prebiotics, formula, and fatty acids.
abstract: OBJECTIVE
  To identify whether nutrient supplementation with probiotics, prebiotics, formula, or fatty acids prevents the development of atopic dermatitis (AD) or reduces the severity of AD in newborns to children younger than 3 years.
  
  
  METHODS
  We searched MEDLINE, Cochrane Central Register of Controlled Trials, and LILACS (Latin American and Caribbean Health Science Literature) from January 1, 1946, to August 27, 2012, and performed an additional manual search.
  
  
  METHODS
  Randomized controlled trials and cohort studies examining nutritional supplementation in prevention and amelioration of AD among children younger than 3 years.
  
  
  METHODS
  Of 92 articles, 21 met inclusion criteria.
  
  
  RESULTS
  In the 21 studies, a total of 6859 participants received supplements, which included infants or mothers who were either pregnant or breastfeeding;4134 infants or mothers served as controls. Nutritional supplementation was shown to be an effective method in preventing AD (11 of 17 studies) or decreasing its severity(5 of 6 studies). The best evidence lies with probiotics supplementation in mothers and infants in preventing development and reducing severity of AD. Specifically, Lactobacillus rhamnosus GG was effective in long-term prevention of AD development. γ-Linolenic acid reduced severity of AD. Supplementation with prebiotics and black currant seed oil (γ-linolenic acid and ω-3 combination) was effective in reducing the development of AD. Conflicting findings were reported from different research groups that performed supplementation with an amino acid–based formula.
  
  
  CONCLUSIONS
  Certain types of nutrient supplementation are beneficial in preventing AD development and reducing its severity. Future research elucidating the mechanisms underlying the actions of nutritional supplementation on AD is necessary.
authors.affiliation: Department of Dermatology, University of California at Davis School of Medicine, Sacramento, CA 95816, USA.
authors.forename: Negar
authors.initials: N
authors.lastname: Foolad
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Brezinski
authors.forename: Elizabeth P
authors.initials: EP
authors.lastname: Chase
authors.forename: April W
authors.initials: AW
authors.lastname: Armstrong
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage; D001942:Breast Feeding; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*; D019587:Dietary Supplements; D005227:Fatty Acids / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000008:administration & dosage / Q000737:chemistry; D007231:Infant, Newborn; D052201:Lacticaseibacillus rhamnosus; D056692:Prebiotics; D011247:Pregnancy; D019936:Probiotics / Q000627:therapeutic use*; D012720:Severity of Illness Index
chemical_list: D000596:Amino Acids; D005227:Fatty Acids; D056692:Prebiotics