title: Diorcinols B-E, new prenylated diphenyl ethers from the marine-derived fungus Aspergillus versicolor ZLN-60.
abstract: Four new prenylated diphenyl ethers (1-4), diorcinols B-E, together with one known diorcinol (5), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures were established on the basis of chemical and spectroscopic data. The absolute configurations of compounds 1 and 2 were determined by Mosher's ester and specific rotation analysis. Their cytotoxicities were evaluated using A-549, Hela, BEL-7402 and K562 cell lines. Compound 3 exhibited moderate cytotoxicities against the Hela and K562 cell lines with the IC50 values of 31.5 and 48.9 μM, respectively, and compound 4 exhibited moderate cytotoxicity only against the Hela cell line with the IC50 value of 36.5 μM.
authors.affiliation: Key laboratory of Marine Drugs, Chinese Ministry of Education, School of Medcine and Pharmacy, Ocean University of China, Qingdao, China.
authors.forename: Huquan
authors.initials: H
authors.lastname: Gao
authors.forename: Lina
authors.initials: L
authors.lastname: Zhou
authors.forename: Shengxin
authors.initials: S
authors.lastname: Cai
authors.forename: Guojian
authors.initials: G
authors.lastname: Zhang
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
authors.forename: Dehai
authors.initials: D
authors.lastname: Li
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000737:chemistry; D001230:Aspergillus / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D015394:Molecular Structure; D010647:Phenyl Ethers / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D000903:Antibiotics, Antineoplastic; D010647:Phenyl Ethers