title: Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells.
abstract: Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering.
authors.affiliation: Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard medical School, Cambridge, MA 02115, USA.
authors.forename: Akhilesh K
authors.initials: AK
authors.lastname: Gaharwar
authors.forename: Silvia M
authors.initials: SM
authors.lastname: Mihaila
authors.forename: Archana
authors.initials: A
authors.lastname: Swami
authors.forename: Alpesh
authors.initials: A
authors.lastname: Patel
authors.forename: Shilpa
authors.initials: S
authors.lastname: Sant
authors.forename: Rui L
authors.initials: RL
authors.lastname: Reis
authors.forename: Alexandra P
authors.initials: AP
authors.lastname: Marques
authors.forename: Manuela E
authors.initials: ME
authors.lastname: Gomes
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
mesh_terms: D002454:Cell Differentiation; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D010012:Osteogenesis; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D017640:Silicates / Q000737:chemistry*; D023822:Tissue Engineering
chemical_list: D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D017640:Silicates