title: Evaluation of the extent and distribution of diffuse axonal injury from real world motor vehicle crashes - biomed 2013.
abstract: Diffuse axonal injury (DAI) is a common traumatic brain injury (TBI) often seen as a result of motor vehicle crashes (MVC). Twelve (12) cases of DAI were selected from the Crash Injury Research and Engineering Network (CIREN) to determine the extent and distribution of injury with respect to the head contact location. Head computed tomography (CT) scans were collected for each subject and segmented using semi-automated methods to establish the volumes of DAI. The impacted area on the subject's head was approximated from evidence of a soft tissue scalp contusion on the CT scan. This was used in conjunction with subject images and identified internal vehicle contact locations to ascertain a label map of the contact location. A point cloud was developed from the contact location label map and the centroid of the point cloud was calculated as the subject's head impact location. The injury and contact location were evaluated in spherical coordinates and grouped into 0.2 by 0.2 radial increments of azimuth and elevation. The radial increments containing DAI were projected onto a meshed sphere to evaluate the radial distance from the impact location to primary location of DAI and approximate anatomical location. Of the 170 injuries observed, 123 were identified in the frontal lobe and 36 in the parietal lobe. The distribution of the DAI in relation to the change in azimuth from the contact loca y correlated with contact to the head superficial to this lobe. Results from this study provide further insight into the biomechanics of traumatic brain injury and can be used in future work as an aid to validate finite element models of the head.
authors.affiliation: Wake Forest University School of Medicine.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Lillie
authors.forename: Jillian E
authors.initials: JE
authors.lastname: Urban
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Lynch
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Whitlow
authors.forename: Joel D
authors.initials: JD
authors.lastname: Stitzel