title: Topical application of tranexamic acid after adenoidectomy: a double-blind, prospective, randomized, controlled study.
abstract: OBJECTIVE
  Is to evaluate the efficacy of tranexamic acid when applied locally in children after primary isolated adenoidectomy with respect to intra-operative blood loss and post-operative bleeding.
  
  
  METHODS
  Prospective, double-blind, randomized, controlled trial.
  
  
  METHODS
  Otolaryngology department, Tanta University and Tiba Hospitals, Egypt.
  
  
  METHODS
  Over three years, 400 children underwent primary isolated adenoidectomy followed by topical application of tranexamic acid (tranexamic acid group, 200 children) or saline (Placebo group, 200 children) with at least two weeks' follow up. Intra-operative blood loss and post-operative hemorrhage were monitored.
  
  
  RESULTS
  Both groups were almost equivalent in age and gender. The frequency of primary post-adenoidectomy hemorrhage as well as the rate of postnasal packing and blood transfusion required to manage severe bleeding were higher in placebo group. The volume of blood loss during surgery showed significant reduction in tranexamic acid group.
  
  
  CONCLUSIONS
  Topical application of tranexamic acid after adenoidectomy led to a significant reduction in blood loss during surgery and decreasing in the rate of post-operative bleeding as well as the need for postnasal packing and blood transfusion.
authors.affiliation: Otolaryngology Department, Tanta University Hospital, Egypt. albirmawy@hotmail.com
authors.forename: Osama A
authors.initials: OA
authors.lastname: Albirmawy
authors.forename: Magdy E
authors.initials: ME
authors.lastname: Saafan
authors.forename: Emad M
authors.initials: EM
authors.lastname: Shehata
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Basuni
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Eldaba
mesh_terms: D000233:Adenoidectomy; D000293:Adolescent; D000933:Antifibrinolytic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006488:Hemostasis, Surgical / Q000379:methods; D006801:Humans; D007223:Infant; D008297:Male; D019106:Postoperative Hemorrhage / Q000188:drug therapy*; D011446:Prospective Studies; D014148:Tranexamic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid