title: Glucocorticosteroids as markers of death from hypothermia.
abstract: In the course of hypothermia, biochemical changes occur that are associated with stimulation of protective thermogenic mechanisms as well as mobilization of internal energy resources mediated by the hormone system. The objective of the investigation was the assessment of validity of determinations of cortisol, cortisone and corticosterone as hypothermia markers in cases of fatal hypothermia combined with concomitant insobriety of the victims. The experimental group consisted of blood samples collected in the course of medico-legal autopsies of 23 hypothermia victims. The controls included blood samples originating from 34 victims of violent sudden deaths (deaths by hanging and traffic road accidents at the scene) and from ten individuals deceased after prolonged agony in consequence of post-traumatic subdural hematomas. In both groups, three subgroups were distinguished that included cases with ethanol levels within the following ranges: 0.0-0.99, 1.0-2.99 and ≥3.0‰. The comparison of determination results showed that irrespectively of blood ethanol concentration, cortisol, cortisone and corticosterone levels seen in hypothermia victims were significantly higher as compared to the controls (P<0.001).
authors.affiliation: Chair and Department of Forensic Medicine, Medical University of Lublin, 20-090 Lublin, Jaczewskiego 8, Poland. krzysztofbanka@wp.pl
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Bańka
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Teresiński
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Buszewicz
authors.forename: Roman
authors.initials: R
authors.lastname: Mądro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002492:Central Nervous System Depressants / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D000431:Ethanol / Q000097:blood; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D006889:Hydroxycorticosteroids / Q000097:blood*; D007035:Hypothermia / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002492:Central Nervous System Depressants; D006889:Hydroxycorticosteroids; D000431:Ethanol