title: Perirenal fat invasion on renal cell carcinoma: evaluation with multidetector computed tomography-multivariate analysis.
abstract: OBJECTIVE
  The objective of this study was to assess the accuracy of multidetector computed tomography (CT) in diagnosing perinephric (PN) and/or renal sinus (RS) fat invasion in patients with renal cell carcinoma (RCC), with reference to the CT findings predictive for the diagnosis of invasion.
  
  
  METHODS
  This was a retrospective study of 48 RCCs. Examinations were performed on a 16-row CT scanner, including unenhanced and 3-phase contrast-enhanced CT scanning. Unenhanced transverse images and multiplanar reformations of each contrast-enhanced CT phase were evaluated. The predictive value of CT findings in diagnosing PN and/or RS fat invasion was determined using multivariate logistic regression analysis.
  
  
  RESULTS
  The CT findings that were most predictive for the diagnosis of PN fat invasion were the presence of contrast-enhancing nodules in the PN fat and tumoral margins. Invasion of the pelvicaliceal system was the most significant predictor in the diagnosis of RS fat invasion.
  
  
  CONCLUSIONS
  Multidetector CT provides satisfactory results in detecting PN and/or RS fat invasion in RCC.
authors.affiliation: Departments of Clinical Radiology, University Hospital of Ioannina, Ioannina, Greece. a_tsili@yahoo.gr
authors.forename: Athina C
authors.initials: AC
authors.lastname: Tsili
authors.forename: Anna C
authors.initials: AC
authors.lastname: Goussia
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Baltogiannis
authors.forename: Loukas
authors.initials: L
authors.lastname: Astrakas
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Sofikitis
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Malamou-Mitsi
authors.forename: Maria I
authors.initials: MI
authors.lastname: Argyropoulou
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D016009:Chi-Square Distribution; D003287:Contrast Media; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D015999:Multivariate Analysis; D011857:Radiographic Image Interpretation, Computer-Assisted; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D003287:Contrast Media