title: Human papilloma virus and esophageal squamous cell carcinoma.
abstract: Human papilloma virus (HPV) has been suggested as an etiology of esophageal squamous cell carcinoma (SCC). The aim of this study was to investigate the prevalence of HPV infection in esophageal SCCs in our region with strict contamination control to prevent false positive results. Thirty cases of esophageal squamous cell carcinomas were chosen by simple random selection in a period of two years. PCR for target sequence of HPV L1 gene was performed on nucleic acid extracted from samples by means of GP5+/GP6+ primers. All tissue samples in both case and control groups were negative for HPV-DNA. Although the number of cases in this study was limited, the contribution of HPV in substantial number of esophageal SCCs in our region is unlikely.
authors.affiliation: Department of Pathology AND Cancer Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hayedeh
authors.initials: H
authors.lastname: Haeri
authors.forename: Omid
authors.initials: O
authors.lastname: Mardany
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Asadi-Amoli
authors.forename: Reza
authors.initials: R
authors.lastname: Shahsiah
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D016022:Case-Control Studies; D015331:Cohort Studies; D004938:Esophageal Neoplasms / Q000473:pathology / Q000821:virology*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors