title: Fluoride concentration from dental sealants: a randomized clinical trial.
abstract: A randomized clinical trial was performed in schoolchildren (6-7 yrs) to evaluate fluoride concentration in interproximal fluid after the placement of 3 different sealants. The sample consisted of 2,776 children randomly divided: 926 in the high-viscosity Glass-ionomer Cement group (GIC group), 923 in the fluoride Resin-based group (fluoride-RB group), and 927 in the no-fluoride Resin-based group (RB group). In total, 2,640 children completed the trial. Sealants were applied following manufacturer's instructions. Interproximal fluid samples were collected at baseline and 2, 7, and 21 days after application of sealants, by insertion of a standardized paperpoint into the interproximal mesial space of the sealed tooth for 15 seconds. Fluoride concentration was evaluated by means of a fluoride ion-selective electrode. At 2 days after sealant application, fluoride concentration was significantly higher in GIC and fluoride-RB groups compared with that in the RB group (p < .01). Mean fluoride concentrations after 7 days were 2.54 (SE 0.68) ppm, 0.85 (SE 0.26) ppm, and 0.53 (SE 0.11) ppm for the three groups, respectively. After 21 days, fluoride concentration in the GIC group remained higher than that in the other two groups. High-viscosity GIC sealants increased the fluoride concentrations in interproximal fluid more than did a Resin-based sealant containing fluoride.
authors.affiliation: Department of Surgery, Microsurgery and Medical Science, School of Dentistry, University of Sassari, Italy. gcampus@uniss.it
authors.forename: G
authors.initials: G
authors.lastname: Campus
authors.forename: G
authors.initials: G
authors.lastname: Carta
authors.forename: M G
authors.initials: MG
authors.lastname: Cagetti
authors.forename: M
authors.initials: M
authors.lastname: Bossù
authors.forename: S
authors.initials: S
authors.lastname: Sale
authors.forename: F
authors.initials: F
authors.lastname: Cocco
authors.forename: G
authors.initials: G
authors.lastname: Conti
authors.forename: M
authors.initials: M
authors.lastname: Nardone
authors.forename: G
authors.initials: G
authors.lastname: Sanna
authors.forename: L
authors.initials: L
authors.lastname: Strohmenger
authors.forename: P
authors.initials: P
authors.lastname: Lingström
mesh_terms: D017438:Bisphenol A-Glycidyl Methacrylate / Q000737:chemistry; D002327:Cariostatic Agents / Q000032:analysis / Q000737:chemistry*; D002648:Child; D003188:Composite Resins / Q000737:chemistry; D004245:DMF Index; D005260:Female; D005459:Fluorides / Q000032:analysis / Q000737:chemistry*; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D005899:Glass Ionomer Cements / Q000737:chemistry; D006801:Humans; D017736:Ion-Selective Electrodes; D008297:Male; D010895:Pit and Fissure Sealants / Q000737:chemistry*; D019279:Resin Cements / Q000737:chemistry; D012923:Social Class; D014783:Viscosity
chemical_list: D002327:Cariostatic Agents; D003188:Composite Resins; D005899:Glass Ionomer Cements; C424245:Ketac-Molar Aplicap; D010895:Pit and Fissure Sealants; D019279:Resin Cements; C059908:Helioseal; D017438:Bisphenol A-Glycidyl Methacrylate; D005459:Fluorides
keywords: clinical trial; community dentistry; dental care for children; fluorides; pit and fissure sealants; saliva