title: Population-level antibody estimates to novel influenza A/H7N9.
abstract: There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.
authors.affiliation: Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam. mboni@oucru.org
authors.forename: Maciej F
authors.initials: MF
authors.lastname: Boni
authors.forename: Nguyen Van Vinh
authors.initials: NV
authors.lastname: Chau
authors.forename: Nguyen
authors.initials: N
authors.lastname: Dong
authors.forename: Stacy
authors.initials: S
authors.lastname: Todd
authors.forename: Nguyen Thi Duy
authors.initials: NT
authors.lastname: Nhat
authors.forename: Erwin
authors.initials: E
authors.lastname: de Bruin
authors.forename: Janko
authors.initials: J
authors.lastname: van Beek
authors.forename: Nguyen Tran
authors.initials: NT
authors.lastname: Hien
authors.forename: Cameron P
authors.initials: CP
authors.lastname: Simmons
authors.forename: Jeremy
authors.initials: J
authors.lastname: Farrar
authors.forename: Marion
authors.initials: M
authors.lastname: Koopmans
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology*; D011446:Prospective Studies; D040081:Protein Array Analysis; D016036:Seroepidemiologic Studies; D014744:Vietnam / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral
keywords: H7N9; influenza; microarray; pandemic; serology