title: Nanocarriers for anticancer drugs--new trends in nanomedicine.
abstract: This review provides a brief overview of the variety of carriers employed for targeted drug delivery used in cancer therapy and summarizes advantages and disadvantages of each approach. Particularly, the attention was paid to polymeric nanocarriers, liposomes, micelles, polyethylene glycol, poly(lactic-co-glycolic acid), dendrimers, gold and magnetic nanoparticles, quantum dots, silica nanoparticles, and carbon nanotubes. Further, this paper briefly focuses on several anticancer agents (paclitaxel, docetaxel, camptothecin, doxorubicin, daunorubicin, cisplatin, curcumin, and geldanamycin) and on the influence of their combination with nanoparticulate transporters to their properties such as cytotoxicity, short life time and/or solubility.
authors.affiliation: Department of Microelectronics, Faculty of Electrical Engineering and Communication, Brno University of Technology, Brno, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Drbohlavova
authors.forename: Jana
authors.initials: J
authors.lastname: Chomoucka
authors.forename: Vojtech
authors.initials: V
authors.lastname: Adam
authors.forename: Marketa
authors.initials: M
authors.lastname: Ryvolova
authors.forename: Tomas
authors.initials: T
authors.lastname: Eckschlager
authors.forename: Jaromir
authors.initials: J
authors.lastname: Hubalek
authors.forename: Rene
authors.initials: R
authors.lastname: Kizek
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D050997:Nanomedicine; D053758:Nanoparticles; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy; D012995:Solubility
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers