title: Emergence of Klebsiella pneumoniae co-producing NDM-type and OXA-181 carbapenemases.
abstract: The emergence of carbapenemase-producing Enterobacteriaceae is a rapidly evolving threat worldwide. Here, we report the molecular characterization of two Klebsiella pneumoniae isolates carrying both bla(OXA -181) and bla(NDM -1) or bla(NDM -5) isolated from epidemiologically unrelated patients in Singapore. The bla(OXA -181) genes were found existing in different genetic environments.
authors.affiliation: Department of Laboratory Medicine, National University Hospital, Singapore City, Singapore. michelle.balm@gmail.com
authors.forename: M N D
authors.initials: MN
authors.lastname: Balm
authors.forename: M-V
authors.initials: MV
authors.lastname: La
authors.forename: P
authors.initials: P
authors.lastname: Krishnan
authors.forename: R
authors.initials: R
authors.lastname: Jureen
authors.forename: R T P
authors.initials: RT
authors.lastname: Lin
authors.forename: J W P
authors.initials: JW
authors.lastname: Teo
mesh_terms: D000293:Adolescent; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism*; D015373:Bacterial Typing Techniques; D002675:Child, Preschool; D004755:Enterobacteriaceae / Q000235:genetics; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000235:genetics* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D011446:Prospective Studies; D012846:Singapore; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1; C063912:carbapenemase
keywords: Carbapenemases; Enterobacteriaceae; gram-negative resistance; metallo-β-lactamases; oxacillinases