title: Histone deacetylase inhibition: an important mechanism in the treatment of lymphoma.
abstract: Lymphomas encompass a group of malignancies that originate in the lymph nodes or other lymphoid tissues. Epigenetic modification, especially by histone deacetylase (HDACs), plays a key role during the occurrence and development of lymphomas. Consequently, HDAC inhibitors (HDACIs), a class of gene expression-modulating drugs, have emerged as promising mechanism-based agents for the treatment of lymphomas. This review presents the rationale of HDAC inhibition, describes the epigenetic-based mechanisms of action of HDACIs, discusses their clinical efficiency, and summarizes the current and future developments in this field.
authors.affiliation: Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, China.
authors.forename: Shan-Qi
authors.initials: SQ
authors.lastname: Guo
authors.forename: Yi-Zhuo
authors.initials: YZ
authors.lastname: Zhang
keywords: epigenomics; histone deacetylases; lymphoma; therapeutics