title: The Effect of Dantonic Pill on β -Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy.
abstract: Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. This study was performed to determine the effect of Dantonic Pill (DP) treatment on β -catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control. Including an analysis of the general metabolic index and renal function, immunohistochemical staining and reverse transcription real-time PCR for β -catenin were performed in the renal cortex of the rat models every 4 weeks. After the treatments of DP and irbesartan, the albuminuria level, kidney weight/body weight, and thickness of the glomerular basement membrane were decreased, but the expression of β -catenin was not downregulated in the renal cortex. The effective drug target of DP to ameliorate albuminuria and renal hypertrophy should not inhibit the upregulated expression of β -catenin in rats with STZ-induced early-stage diabetic damage.
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Shuhong
authors.forename: Lv
authors.initials: L
authors.lastname: Hongjun
authors.forename: Cui
authors.initials: C
authors.lastname: Bo
authors.forename: Xu
authors.initials: X
authors.lastname: Li
authors.forename: Shi
authors.initials: S
authors.lastname: Bingyin