title: Large-cell neuroendocrine carcinoma of prostate. Case report.
abstract: OBJECTIVE
  To report a case of a neuroendocrine differentiation in a prostate cancer patient, a rare subtype.
  
  
  METHODS
  We describe the case of a patient diagnosed with adenocarcinoma of the prostate initially, who presented hematuria due to disease progression with neuroendocrine differentiation despite androgen-deprivation therapy (ADT ).
  
  
  CONCLUSIONS
  Prostate cancer is the most common tumor in men. Histologically they are diagnosed as adenocarcinomas, which followed by ADT for a long time, develop neuroendocrine differentiation (NED ).
  
  
  CONCLUSIONS
  The prognostic significance of NED remains controversial. We must think in neuroendocrine differentiation in ADT-treated patient with disease progression and low PSA.
authors.affiliation: Service of Urology, Hospital Universitario Dr. Peset, Valencia, Spain. luzmoratalla@comv.es
authors.forename: Luz Maria
authors.initials: LM
authors.lastname: Moratalla Charcos
authors.forename: Teresa
authors.initials: T
authors.lastname: Pastor Navarro
authors.forename: Virginia
authors.initials: V
authors.lastname: Cortes Vizcaino
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Osca Garcia
authors.forename: Manuel
authors.initials: M
authors.lastname: Gil Salom
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D003131:Combined Modality Therapy; D000077143:Docetaxel; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D043823:Taxoids / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin; D017430:Prostate-Specific Antigen