title: Feasibility and safety of magnetic-controlled capsule endoscopy system in examination of human stomach: a pilot study in healthy volunteers.
abstract: OBJECTIVE
  To assess the feasibility and safety of magnetic-controlled capsule endoscopy (MCE) system for examination of human stomach.
  
  
  METHODS
  This pilot study enrolled 34 healthy volunteers. All subjects swallowed the MCE and gas-producing powder for gastric distention. An external robot was used to generate magnetic field to manipulate MCE inside the stomach. The primary measurements included safety, gastric preparation, maneuverability and visualization of gastric mucosa.
  
  
  RESULTS
  Gastric preparation and examination was well accepted by subjects and there were no adverse events. The examination in the stomach takes 43.8±10.0min (27-60). The cleanliness was evaluated as good in the 30 (88.2%) subjects and as moderate in 4 (11.8%) subjects. The distention of gastric cavity was evaluated as good in the 29 (85.3%) subjects and moderate in 5 (14.7%) subjects. Maneuverability of the MCE to movements of the guidance magnet robot was graded as good in 29 (85.3%) subjects and moderate in 5 (14.7%) subjects. More than 75% gastric mucosa was visualized in 27 (79.4%) subjects and 50% to 75% in 7 (20.6%) subjects. Visualization of the gastric cardia, fundus, body, angulus, antrum and pylorus was subjectively assessed as complete in 82.4%, 85.3%, 100.0%, 100.0%, 100.0% and 100.0%, respectively. Polyp and erosive lesions were found in 7 subjects.
  
  
  CONCLUSIONS
  Magnetic-controlled capsule endoscopy used for examination of the human stomach is feasible and safe.
authors.affiliation: Digestive Endoscopy Center, Department of Gastroenterology, Chinghai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Zhuan
authors.initials: Z
authors.lastname: Liao
authors.affiliation: University of Shanghai for Science & Technology, Shanghai, China.|Engineering Research Center of Optical Instrument and System, Ministry of Education and Shanghai Key Lab of Modern Optical System.|ANKON Technologies Co. LTD, Wuhan, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Duan
authors.affiliation: Digestive Endoscopy Center, Department of Gastroenterology, Chinghai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xin
authors.affiliation: Digestive Endoscopy Center, Department of Gastroenterology, Chinghai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Lu-Min
authors.initials: LM
authors.lastname: Bo
authors.affiliation: University of Shanghai for Science & Technology, Shanghai, China.|Engineering Research Center of Optical Instrument and System, Ministry of Education and Shanghai Key Lab of Modern Optical System.|ANKON Technologies Co. LTD, Wuhan, China.
authors.forename: Xin-Hong
authors.initials: XH
authors.lastname: Wang
authors.affiliation: University of Shanghai for Science & Technology, Shanghai, China.|Engineering Research Center of Optical Instrument and System, Ministry of Education and Shanghai Key Lab of Modern Optical System.|ANKON Technologies Co. LTD, Wuhan, China.
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Xiao
authors.affiliation: Digestive Endoscopy Center, Department of Gastroenterology, Chinghai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Liang-Hao
authors.initials: LH
authors.lastname: Hu
authors.affiliation: University of Shanghai for Science & Technology, Shanghai, China.|Engineering Research Center of Optical Instrument and System, Ministry of Education and Shanghai Key Lab of Modern Optical System.
authors.forename: Song-Lin
authors.initials: SL
authors.lastname: Zhuang
authors.affiliation: Digestive Endoscopy Center, Department of Gastroenterology, Chinghai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Zhao-Shen
authors.initials: ZS
authors.lastname: Li
keywords: capsule endoscopy; feasibility studies; magnetic-controlled; robot