title: Appearance of osteolysis with melorheostosis: redefining the disease or a new disorder? A novel case report with multimodality imaging.
abstract: We present a case report of melorheostosis with the novel radiographic finding of underlying cortical resorption. A number of radiographic patterns of melorheostosis have been described; however, the combination of new bone formation and resorption of the original cortex appears unique. Although the presence of underlying lysis has been postulated in published studies, direct radiographic evidence of bony resorption in melorheostosis has not been reported. These findings can be subtle and might go unnoticed using standard imaging. An in-depth review of the radiographic features is presented, including multimodality imaging with magnetic resonance imaging and computed tomography.
authors.affiliation: Kent State University College of Podiatric Medicine, Independence, OH 44131, USA. losher@kent.edu
authors.forename: Lawrence S
authors.initials: LS
authors.lastname: Osher
authors.forename: Marie Mantini
authors.initials: MM
authors.lastname: Blazer
authors.forename: Kelly
authors.initials: K
authors.lastname: Bumpus
mesh_terms: D005260:Female; D005529:Foot Bones / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008557:Melorheostosis / Q000175:diagnosis*; D008875:Middle Aged; D064847:Multimodal Imaging; D010014:Osteolysis / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed
keywords: 4; SOST; melorheostosis; osteolysis; sclerosing bone dysplasia; sclerotomes