title: Improvement of brain uptake for in vivo PET imaging of astrocytic oxidative metabolism using benzyl [1-(11)C]acetate.
abstract: Brain uptake of acetate is insufficient for obtaining a quantitative image of astrocytic oxidative metabolism. To improve the brain uptake of [1-(11)C]acetate, we synthesized benzyl [1-(11)C]acetate ([1-(11)C]BA) and conducted a positron emission tomography (PET) study assessing astrocytic oxidative metabolism. The brain uptake of [1-(11)C]BA was markedly higher compared with [1-(11)C]acetate, and disappeared with a half-life of 20 min in all regions studied. The brain uptake of [1-(11)C]BA was significantly decreased by fluorocitrate. The results indicate that [1-(11)C]BA could be a useful PET probe for assessing astrocytic oxidative metabolism.
authors.affiliation: Molecular Imaging Centre, National Institute of Radiological Sciences, 4-9-1 Anagawa, Chiba 263-8555, Japan. mokada@nirs.go.jp
authors.forename: Maki
authors.initials: M
authors.lastname: Okada
authors.forename: Ryuji
authors.initials: R
authors.lastname: Nakao
authors.forename: Sotaro
authors.initials: S
authors.lastname: Momosaki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yanamoto
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Okamura
authors.forename: Hidekatsu
authors.initials: H
authors.lastname: Wakizaka
authors.forename: Rie
authors.initials: R
authors.lastname: Hosoi
authors.forename: Ming-Rong
authors.initials: MR
authors.lastname: Zhang
authors.forename: Osamu
authors.initials: O
authors.lastname: Inoue
mesh_terms: D000085:Acetates / Q000493:pharmacokinetics*; D000818:Animals; D001253:Astrocytes / Q000000981:diagnostic imaging* / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002244:Carbon / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
chemical_list: D000085:Acetates; D019275:Radiopharmaceuticals; C438206:carbon-11 acetate; D002244:Carbon