title: Tumor lysis syndrome and malignant melanoma.
abstract: Tumor lysis syndrome (TLS) is an oncological emergency that results from massive cytolysis of malignant cells with a sudden release of their contents into the systemic circulation. TLS was rarely described in patients with malignant melanoma. In this article, we describe two patients with malignant melanoma who developed this syndrome. In one of them, the syndrome occurred spontaneously, and this is the second description of spontaneous tumor lysis in a patient with melanoma. We reviewed the previous patients with melanoma-induced TLS and discussed the manifestations and the pathophysiology of the syndrome in our patients.
authors.affiliation: Department of Medicine E, Sheba Medical Center and Sackler School of Medicine, Tel-Aviv University, Tel-Hashomer 52621, Israel. mouallem@post.tau.ac.il
authors.forename: Meir
authors.initials: M
authors.lastname: Mouallem
authors.forename: Noa
authors.initials: N
authors.lastname: Zemer-Wassercug
authors.forename: Eitan
authors.initials: E
authors.lastname: Kugler
authors.forename: Nadav
authors.initials: N
authors.lastname: Sahar
authors.forename: Ronnie
authors.initials: R
authors.lastname: Shapira-Frommer
authors.forename: Ginette
authors.initials: G
authors.lastname: Schiby
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D008545:Melanoma / Q000150:complications / Q000503:physiopathology*; D015275:Tumor Lysis Syndrome / Q000209:etiology / Q000503:physiopathology*