title: Transplant rejection and paradigms lost.
abstract: During transplant rejection, migrating T cells infiltrate the grafted organ, but the signals that direct this migration are incompletely understood. In this issue of the JCI, Walch et al. debunk two classical paradigms concerning transplant rejection, with important consequences for the design of antirejection therapeutics.
authors.affiliation: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. tstrom@bidmc.harvard.edu
authors.forename: Terry B
authors.initials: TB
authors.lastname: Strom
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D016027:Heart Transplantation / Q000276:immunology*; D016030:Kidney Transplantation / Q000276:immunology*; D057705:Transendothelial and Transepithelial Migration / Q000276:immunology*