title: Activity of matrix metalloproteinases during antimycobacterial therapy in mice with simulated tuberculous inflammation.
abstract: Matrix metalloproteinases are shown to be involved in the pathogenesis of tuberculosis inflammation. In the early stages of BCG-granuloma formation in mouse liver and lungs, the serum levels of matrix metalloproteinases 2 and 7 increased by 4.5 times and remained unchanged while the pathology developed. Antimycobacterial therapy with isoniazid reduced enzyme activity almost to the level of intact control. The decrease in activity of matrix metalloproteinases 2 and 7 that play the most prominent role in the development of destructive forms of tuberculosis is of great therapeutic importance.
authors.affiliation: Institute of Biochemistry, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. dinasumenkova@mail.ru
authors.forename: D V
authors.initials: DV
authors.lastname: Sumenkova
authors.forename: G S
authors.initials: GS
authors.lastname: Russkikh
authors.forename: O N
authors.initials: ON
authors.lastname: Poteryaeva
authors.forename: L M
authors.initials: LM
authors.lastname: Polyakov
authors.forename: L E
authors.initials: LE
authors.lastname: Panin
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D007538:Isoniazid / Q000627:therapeutic use*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D020783:Matrix Metalloproteinase 7 / Q000097:blood*; D051379:Mice; D008808:Mice, Inbred CBA; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000201:enzymology* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D020783:Matrix Metalloproteinase 7; D020778:Matrix Metalloproteinase 2; D007538:Isoniazid