title: The in vitro effect of commercially available noble metal nanocolloids on the rainbow trout (Oncorhynchus mykiss) leukocyte and splenocyte activity.
abstract: The growing popularity of nanotechnology in the past decade has increased nanomaterial concentrations in the environment and the risk of their toxicity for aquatic organisms. Metal nanoparticles, which are easily absorbed and accumulated by fish, are probably able to interact directly with their immunocompetent cells. The objective of this study was to evaluate the in vitro effect of commercially available silver, gold and copper nanocolloids on the rainbow trout leukocyte and splenocyte activity. At high concentrations, all of the nanocolloids studied had adverse effects on the proliferative response of trout lymphocytes, and the most toxic of them, silver, decreased also the respiratory burst activity of splenocytes. Low concentrations of silver nanocolloid, however, had a stimulating effect on the lymhocyte proliferation.
authors.affiliation: Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine University of Warmia and Mazury, Oczapowskiego 13, 10-718 Olsztyn, Poland. j.malaczewska7@wp.pl
authors.forename: J
authors.initials: J
authors.lastname: Małaczewska
authors.forename: A K
authors.initials: AK
authors.lastname: Siwicki
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D003102:Colloids / Q000737:chemistry; D007962:Leukocytes / Q000187:drug effects*; D053768:Metal Nanoparticles; D017686:Oncorhynchus mykiss; D013154:Spleen / Q000166:cytology*
chemical_list: D003102:Colloids