title: Translation inhibition and metabolic stress pathways in the host response to bacterial pathogens.
abstract: Activation of most major innate immune signalling cascades relies on the detection of microorganisms or their associated danger signals by host pattern recognition molecules. A flurry of recent studies has now uncovered a role for host translation inhibition in innate immune surveillance and the detection of bacterial pathogens. Here, we present the main findings from these studies and discuss whether translation inhibition is an alarm signal that directly drives innate immune responses to bacterial pathogens, or rather one component of a more general metabolic stress response to infection.
authors.affiliation: Global Health Institute, School of Life Science, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. bruno.lemaitre@epfl.ch
authors.forename: Bruno
authors.initials: B
authors.lastname: Lemaitre
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Girardin
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000276:immunology*; D054884:Host-Pathogen Interactions; D008954:Models, Biological; D014176:Protein Biosynthesis / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D013312:Stress, Physiological / Q000502:physiology*