title: [Evaluation of factors associated with tuberculosis treatment default in Chad].
abstract: BACKGROUND
  Tuberculosis (TB) treatment default contributes to the perpetuation of the epidemic and increases the risk of emergence of new forms of multidrug-resistant TB. The aim of this study was to identify the factors associated with treatment default in Chad.
  
  
  METHODS
  This prospective study interviewed 286 patients with pulmonary TB in three centers, recruited at the beginning of treatment. We compared patients who completed the treatment to the treatment defaulters. A logistic regression model was fit to identify factors associated with default.
  
  
  RESULTS
  32% of patients defaulted, that is, abandoned treatment. The multivariate analysis demonstrated that a low educational level and ignorance of the contagious nature of TB were associated with treatment interruption.
  
  
  CONCLUSIONS
  TB education, patient assistance, and active tracing of patients who fail to return can help to prevent abandonment of TB treatment.
authors.affiliation: INSERM UMRS 707, Université Pierre et Marie Curie-Paris 6, UMRS 707, 27 rue Chaligny, Paris, France. ndeindo@hotmail.fr
authors.forename: N
authors.initials: N
authors.lastname: Ndeikoundam Ngangro
authors.forename: D
authors.initials: D
authors.lastname: Ngarhounoum
authors.forename: M N
authors.initials: MN
authors.lastname: Ngangro
authors.forename: N
authors.initials: N
authors.lastname: Rangar
authors.forename: V
authors.initials: V
authors.lastname: Halley des Fontaines
authors.forename: P
authors.initials: P
authors.lastname: Chauvin
mesh_terms: D000293:Adolescent; D000328:Adult; D002596:Chad; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D055815:Young Adult; D016903:Drug Monitoring
keywords: Chad; adherence; treatment; tuberculosis