title: Computational fluid dynamic simulations of image-based stented coronary bifurcation models.
abstract: One of the relevant phenomenon associated with in-stent restenosis in coronary arteries is an altered haemodynamics in the stented region. Computational fluid dynamics (CFD) offers the possibility to investigate the haemodynamics at a level of detail not always accessible within experimental techniques. CFD can quantify and correlate the local haemodynamics structures which might lead to in-stent restenosis. The aim of this work is to study the fluid dynamics of realistic stented coronary artery models which replicate the complete clinical procedure of stent implantation. Two cases of pathologic left anterior descending coronary arteries with their bifurcations are reconstructed from computed tomography angiography and conventional coronary angiography images. Results of wall shear stress and relative residence time show that the wall regions more prone to the risk of restenosis are located next to stent struts, to the bifurcations and to the stent overlapping zone for both investigated cases. Considering a bulk flow analysis, helical flow structures are generated by the curvature of the zone upstream from the stent and by the bifurcation regions. Helical recirculating microstructures are also visible downstream from the stent struts. This study demonstrates the feasibility to virtually investigate the haemodynamics of patient-specific coronary bifurcation geometries.
authors.affiliation: Chemistry, Materials and Chemical Engineering Department, Politecnico di Milano, Milan, Italy. claudio.chiastra@polimi.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Chiastra
authors.forename: Stefano
authors.initials: S
authors.lastname: Morlacchi
authors.forename: Diego
authors.initials: D
authors.lastname: Gallo
authors.forename: Umberto
authors.initials: U
authors.lastname: Morbiducci
authors.forename: Rubén
authors.initials: R
authors.lastname: Cárdenes
authors.forename: Ignacio
authors.initials: I
authors.lastname: Larrabide
authors.forename: Francesco
authors.initials: F
authors.lastname: Migliavacca
mesh_terms: D001696:Biomechanical Phenomena; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000503:physiopathology*; D003331:Coronary Vessels / Q000473:pathology*; D006439:Hemodynamics; D006801:Humans; D008953:Models, Anatomic; D008955:Models, Cardiovascular
keywords: computational fluid dynamics; coronary bifurcation; helicity; patient-specific model; stent; wall shear stress