title: Future of the particle replication in nonwetting templates (PRINT) technology.
abstract: Particle replication in nonwetting templates (PRINT) is a continuous, roll-to-roll, high-resolution molding technology which allows the design and synthesis of precisely defined micro- and nanoparticles. This technology adapts the lithographic techniques from the microelectronics industry and marries these with the roll-to-roll processes from the photographic film industry to enable researchers to have unprecedented control over particle size, shape, chemical composition, cargo, modulus, and surface properties. In addition, PRINT is a GMP-compliant (GMP=good manufacturing practice) platform amenable for particle fabrication on a large scale. Herein, we describe some of our most recent work involving the PRINT technology for application in the biomedical and material sciences.
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Dominica H C
authors.initials: DH
authors.lastname: Wong
authors.forename: James D
authors.initials: JD
authors.lastname: Byrne
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.forename: Charles
authors.initials: C
authors.lastname: Bowerman
authors.forename: Joseph M
authors.initials: JM
authors.lastname: DeSimone
mesh_terms: D001702:Biopharmaceutics / Q000379:methods; D015195:Drug Design; D004574:Electromagnetic Fields; D004581:Electronics; D006801:Humans; D008422:Materials Testing; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D011355:Prodrugs / Q000138:chemical synthesis; D034741:RNA, Small Interfering / Q000378:metabolism; D013499:Surface Properties
chemical_list: D011355:Prodrugs; D034741:RNA, Small Interfering