title: Novel nonsurgical left ventricular assist device and system.
abstract: Treatment options for advanced stages of congestive heart failure remain limited. Left ventricular assist devices (LVADs) have emerged as a means to support failing circulation. However, these devices are not without significant risk such as major open chest surgery. We utilized a novel approach for device placement at the aorto-left atria continuity as a site to create a conduit capable of accommodating a percutaneous LVAD system. We designed and developed an expandable nitinol based device for placement at this site to create a shunt between the LA and aorta. Our experiments support this anatomic location as an accessible and feasible site for accommodation of an entirely percutaneous LVAD. The novelty of this approach would bypass the left ventricle, and thereby minimize complications and morbidities associated with current LVAD placement.
authors.affiliation: Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Juna
authors.initials: J
authors.lastname: Misiri
authors.forename: Christopher V
authors.initials: CV
authors.lastname: DeSimone
authors.forename: Soon J
authors.initials: SJ
authors.lastname: Park
authors.forename: Sudhir S
authors.initials: SS
authors.lastname: Kushwaha
authors.forename: Paul A
authors.initials: PA
authors.lastname: Friedman
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Bruce
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Asirvatham
mesh_terms: D000497:Alloys; D000818:Animals; D006328:Cardiac Catheterization / Q000295:instrumentation*; D004285:Dogs; D006333:Heart Failure / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D023421:Models, Animal; D011474:Prosthesis Design; D016277:Ventricular Function, Left
chemical_list: D000497:Alloys; C013616:nitinol