title: Enantioselective, desymmetrizing bromolactonization of alkynes.
abstract: Asymmetric bromolactonizations of alkynes are possible using a desymmetrization approach. The commercially available catalyst (DHQD)2PHAL promotes these cyclizations in combination with cheap NBS as a bromine source to give bromoenol lactones in high yield and with high enantioselectivity. The bromoenol lactone products, containing a tetrasubstituted alkene and a quaternary stereocenter, are valuable building blocks for synthetic chemistry.
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster , Corrensstrasse 40, 48149 Münster, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Wilking
authors.forename: Christian
authors.initials: C
authors.lastname: Mück-Lichtenfeld
authors.forename: Constantin G
authors.initials: CG
authors.lastname: Daniliuc
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hennecke