title: Solid-state amorphization of linaprazan by mechanical milling and evidence of polymorphism.
abstract: In this paper, we study the thermodynamic and structural changes of crystalline linaprazan (a proton pump inhibitor) upon high-energy ball milling at room temperature. The investigations have been performed by differential scanning calorimetry and powder X-ray diffraction. The results indicate that this drug undergoes a direct crystal-to-glass transformation upon milling. Moreover, upon heating, the amorphous material obtained by milling is shown to recrystallize toward two different polymorphs that appear to form a monotropic set.
authors.affiliation: Université Lille Nord de France, F-59000 Lille, France. jean-francois.willart@univ-lille1.fr
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Willart
authors.forename: Morgan
authors.initials: M
authors.lastname: Durand
authors.forename: Lars-Erik
authors.initials: LE
authors.lastname: Briggner
authors.forename: Anke
authors.initials: A
authors.lastname: Marx
authors.forename: Florence
authors.initials: F
authors.lastname: Danède
authors.forename: Marc
authors.initials: M
authors.lastname: Descamps
mesh_terms: D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D004339:Drug Compounding; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry*; D010316:Particle Size; D044367:Phase Transition; D033362:Powder Diffraction; D054328:Proton Pump Inhibitors / Q000737:chemistry*; D013816:Thermodynamics; D014961:X-Ray Diffraction
chemical_list: D006574:Heterocyclic Compounds, 2-Ring; D054328:Proton Pump Inhibitors; C585414:linaprazan