title: Factors influencing overall survival specific to adult low-grade astrocytoma: a population-based study.
abstract: OBJECTIVE
  We report a population-based overall survival and prognostic factor analysis specific to adult patients diagnosed with low-grade astrocytoma (LGA).
  
  
  METHODS
  All histologically confirmed cases of LGA diagnosed between 1992 and 1996 in the province of Ontario, Canada, were identified from the Ontario Cancer Registry and reviewed.
  
  
  RESULTS
  In total, 182 patients were identified; the mean age was 50 years and the mean survival time was 4.1 years (standard deviation = 5.1 years). Fifty-four per cent of patients had a surgical excision and 46% were biopsied alone. Both univariate and multivariate analyses showed that patients aged <30 years were significantly more likely to undergo an excision as compared with a biopsy alone (odds ratio = 4.26, 95% confidence interval 1.54-11.77). For the entire cohort, we observed a significant relationship between decreasing survival as a function of increasing age at diagnosis. In the biopsy sub-group, relative to patient's age <30 years, the hazard of dying increased significantly according to age when stratified by decade. However, in those patients having had a primary surgical excision, the hazard of dying relative to patient's age <30 years was similar for those aged 30-49 years and then significantly greater as patient age surpassed 50 years.
  
  
  CONCLUSIONS
  Age is a significant prognostic factor for LGA. Our analysis suggests that in those patients amenable to a primary tumour excision, a survival benefit may be confined to those under age 50 years.
authors.affiliation: Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. Arjun.Sahgal@sunnybrook.ca
authors.forename: A
authors.initials: A
authors.lastname: Sahgal
authors.forename: S A
authors.initials: SA
authors.lastname: Ironside
authors.forename: J
authors.initials: J
authors.lastname: Perry
authors.forename: T
authors.initials: T
authors.lastname: Mainprize
authors.forename: J L
authors.initials: JL
authors.lastname: Keith
authors.forename: N
authors.initials: N
authors.lastname: Laperriere
authors.forename: M
authors.initials: M
authors.lastname: Tsao
authors.forename: L
authors.initials: L
authors.lastname: Paszat
mesh_terms: D000328:Adult; D000367:Age Factors; D001254:Astrocytoma / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D001706:Biopsy; D001932:Brain Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009864:Ontario / Q000453:epidemiology; D011379:Prognosis; D012042:Registries; D015996:Survival Rate