title: Association of epicardial adipose tissue thickness by echocardiography and hypertension.
abstract: OBJECTIVE
  Epicardial adipose tissue (EAT) is a component of visceral adiposity with endocrine and paracrine effects. It is also associated with metabolic syndrome (MetS). In this study, we investigated the relationship between EAT thickness and hypertension that is a component of MetS.
  
  
  METHODS
  Enrolled in this study were 140 hypertensive patients and 60 age- and sex-similar normotensive controls. EAT thickness was measured using 2-D echocardiography from the parasternal long- and short-axis views. EAT thicknesses were compared between patients with hypertension and controls. The effects of hypertension on EAT thickness were evaluated like other components of MetS.
  
  
  RESULTS
  EAT thickness was increased in hypertensive patients compared to normotensive controls (6.3 ± 1.7 mm vs. 5.3 ± 1.6 mm; p<0.001). EAT thickness correlated with systolic and diastolic blood pressures (r=0.233, p=0.001; r=0.144, p=0.047, respectively). EAT thickness was further increased in patients with uncontrolled hypertension than in those with controlled hypertension (6.6 ± 1.7 mm vs. 5.9 ± 1.8 mm, p=0.046). When linear regression analysis was performed to assess the effect of hypertension on EAT thickness like the other components of MetS, hypertension (p=0.009, 95% CI 0.236-1.619), waist circumference (p=0.003, 95%CI 0.339-1.640), HDL-cholesterol (p=0.046, 95% CI, -0.054 - 0.001) and blood glucose levels (p=0.007, 95% CI, 0.003-0.002) were found to be independent correlates of EAT thickness.
  
  
  CONCLUSIONS
  EAT thickness is associated with hypertension. Hypertension could be contributing factor for the development of EAT thickness like the other components of MetS.
authors.affiliation: Department of Cardiology, Başkent University Faculty of Medicine, Ankara, Turkey. serpileroglu@gmail.com
authors.forename: Serpil
authors.initials: S
authors.lastname: Eroğlu
authors.forename: Leyla Elif
authors.initials: LE
authors.lastname: Sade
authors.forename: Aylin
authors.initials: A
authors.lastname: Yıldırır
authors.forename: Ozlem
authors.initials: O
authors.lastname: Demir
authors.forename: Haldun
authors.initials: H
authors.lastname: Müderrisoğlu
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000473:pathology*; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D010496:Pericardium / Q000000981:diagnostic imaging* / Q000473:pathology; D015203:Reproducibility of Results