title: [Pathogenesis of periodontal cell DNA damage during periodontitis].
abstract: Objective of our work: To carry out a comparative assessment of the expression level p53 protein and associate it with the degree of DNA damage in inflammation of periodontal disease. The research was conducted on periodontal tissue with signs of inflammation taken from dead patients of Sumy Regional Hospital. The materials were investigated using immunohistochemistry and DNA comet assay. It was established that acute inflammation in the periodontal tissues develop changes leading to DNA damage Acute inflammation is characterized by high levels of p53 Considerable damage to the nuclear DNA is called p53. p53 in apoptosis may include inability to repair.
authors.forename: E V
authors.initials: EV
authors.lastname: Kuzenko
authors.forename: A N
authors.initials: AN
authors.lastname: Romaniuk
authors.forename: A M
authors.initials: AM
authors.lastname: Politun
authors.forename: R A
authors.initials: RA
authors.lastname: Moskalenko
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000235:genetics; D001344:Autopsy; D004247:DNA / Q000032:analysis*; D004249:DNA Damage / Q000235:genetics; D005260:Female; D005786:Gene Expression Regulation; D005881:Gingiva / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000378:metabolism* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D004247:DNA