title: Trikatu, a herbal compound that suppresses monosodium urate crystal-induced inflammation in rats, an experimental model for acute gouty arthritis.
abstract: Gout is an inflammatory joint disorder characterized by hyperuricaemia and precipitation of monosodium urate crystals in the joints. In the present study, we aimed to investigate the anti-inflammatory effect of trikatu, a herbal compound in monosodium urate crystal-induced inflammation in rats, an experimental model for acute gouty arthritis. Paw volume and levels/activities of lysosomal enzymes, lipid peroxidation, anti-oxidant status and histopathological examination of ankle joints were determined in control and monosodium urate crystal-induced rats. In addition, analgesic (acetic acid-induced writhing response), anti-pyretic (yeast-induced pyrexia) and gastric ulceration effects were tested. The levels of lysosomal enzymes, lipid peroxidation and paw volume were significantly increased, and anti-oxidant status was found to be reduced in monosodium urate crystal-induced rats, whereas the biochemical changes were reverted to near normal levels upon trikatu (1000 mg/kg b.wt) administration. The trikatu has also been found to exhibit significant analgesic and anti-pyretic effects with the absence of gastric damage. In conclusion, the present results clearly indicated that trikatu exert a potent anti-inflammatory effect against monosodium urate crystal-induced inflammation in rats in association with analgesic and anti-pyretic effects in the absence of gastrointestinal damage.
authors.affiliation: Immunopathology Lab, School of Bio Sciences and Technology, VIT University, Vellore, India.
authors.forename: Vachana
authors.initials: V
authors.lastname: Murunikkara
authors.forename: Mahaboobkhan
authors.initials: M
authors.lastname: Rasool
mesh_terms: D000208:Acute Disease; D000475:Alkenes / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D015210:Arthritis, Gouty / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005638:Fruit; D020939:Zingiber officinale; D006074:Gout Suppressants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D007213:Indomethacin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D015227:Lipid Peroxidation; D008297:Male; D031701:Piper; D010880:Piperidines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014527:Uric Acid
chemical_list: D000475:Alkenes; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006074:Gout Suppressants; D010880:Piperidines; C540456:trikatu; D014527:Uric Acid; D007213:Indomethacin
keywords: MSU-induced inflammation; gouty arthritis; trikatu