title: Cytoskeletal disease: a role in the etiology of adult periodontitis.
abstract: All cells and organisms across the evolutionary spectrum, from the most primitive to the most complex, are mechanosensitive. As the cytoskeleton is a key in controlling the normal basal prestress of cells and therefore is involved in virtually all physiological cellular processes, abnormalities in this essential cellular characteristic may result in diseases. Indeed, many diseases have now been associated with abnormalities in cytoskeletal and nucleoskeletal proteins. We propose that adult periodontitis is, at least in part, such a cytoskeletal disease. It is well established that adult periodontitis starts by bacterial invasion at the interface between the tooth surface and marginal gingiva that induces a local inflammatory response. The inflammatory cells release metalloproteinases which degrade gingival collagenous fibrous tissue and loss of local tissue integrity that reduces the normal prestressed cell-extracellular matrix network. This is a major signaling trigger that induces a local and rapid release of ATP, which then activates P2X receptors and stimulates a calcium influx, further activating osteoclastic resorption of the alveolar bone. As periodontitis is a chronic disease, it seems reasonable to suggest that agents that maintain cytoskeletal tensegrity, for example, inhibitors of ATP receptors, may diminish the bone loss and may have a role in future periodontal therapy.
authors.affiliation: Department of Oral Biology, Sackler Faculty of Medicine, Maurice and Gabriela Goldschleger, School of Dental Medicine, Tel Aviv, Israel; Department of Bio-Medical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Binderman
authors.forename: N
authors.initials: N
authors.lastname: Gadban
authors.forename: A
authors.initials: A
authors.lastname: Yaffe
mesh_terms: D001862:Bone Resorption / Q000209:etiology; D055113:Chronic Periodontitis / Q000150:complications / Q000209:etiology* / Q000473:pathology; D003598:Cytoskeletal Proteins; D005881:Gingiva / Q000473:pathology; D006801:Humans
chemical_list: D003598:Cytoskeletal Proteins
keywords: alveolar bone resorption; disruption of fibrous tissue; periodontitis; prestressed marginal gingiva; reduction of tensile strains in cytoskeleton