title: Expression of Angiotensin II and Aldosterone in Radiation-induced Lung Injury.
abstract: OBJECTIVE
  Radiation-induced lung injury (RILI) is the most common, dose-limiting complication in thoracic malignancy radiotherapy. Considering its negative impact on patients and restrictions to efficacy, the mechanism of RILI was studied.
  
  
  METHODS
  Wistar rats were locally irradiated with a single dose of 0, 16, and 20 Gy to the right half of the lung to establish a lung injury model. Two and six months after irradiation, the right half of the rat lung tissue was removed, and the concentrations of TGF-β1, angiotensin II, and aldosterone were determined via enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Statistical differences were observed in the expression levels of angiotensin II and aldosterone between the non-irradiation and irradiation groups. Moreover, the expression level of the angiotensin II-aldosterone system increased with increasing doses, and the difference was still observed as time progressed.
  
  
  CONCLUSIONS
  Angiotensin II-aldosterone system has an important pathophysiological function in the progression of RILI.
authors.affiliation: Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Cao
authors.forename: Rong
authors.initials: R
authors.lastname: Wu
keywords: aldosterone; angiotensin II; lung; radiation injury; rats; transforming growth factor-β1