title: Not reinventing the wheel: applying the 3Rs concepts to viral vector gene therapy biodistribution studies.
authors.affiliation: Department of Preclinical Safety, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA. timothy.maclachlan@novartis.com
authors.forename: Timothy K
authors.initials: TK
authors.lastname: MacLachlan
authors.forename: Maritza
authors.initials: M
authors.lastname: McIntyre
authors.forename: Kyriacos
authors.initials: K
authors.lastname: Mitrophanous
authors.forename: James
authors.initials: J
authors.lastname: Miskin
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Jolly
authors.forename: Joy A
authors.initials: JA
authors.lastname: Cavagnaro
mesh_terms: D004353:Drug Evaluation, Preclinical; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000235:genetics / Q000378:metabolism*; D017408:Guidelines as Topic; D006801:Humans; D014018:Tissue Distribution; D019076:Transgenes; D014780:Viruses / Q000235:genetics*