title: Comparison Study of Airway Reactivity Outcomes due to a Pharmacologic Challenge Test: Impulse Oscillometry versus Least Mean Squared Analysis Techniques.
abstract: The technique of measuring transpulmonary pressure and respiratory airflow with manometry and pneumotachography using the least mean squared analysis (LMS) has been used broadly in both preclinical and clinical settings for the evaluation of neonatal respiratory function during tidal volume breathing for lung tissue and airway frictional mechanical properties measurements. Whereas the technique of measuring respiratory function using the impulse oscillation technique (IOS) involves the assessment of the relationship between pressure and flow using an impulse signal with a range of frequencies, requires less cooperation and provides more information on total respiratory system resistance (chest wall, lung tissue, and airways). The present study represents a preclinical animal study to determine whether these respiratory function techniques (LMS and IOS) are comparable in detecting changes in respiratory resistance derived from a direct pharmacological challenge.
authors.affiliation: Nemours Research Lung Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA ; Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA ; Division of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: Elena
authors.initials: E
authors.lastname: Rodriguez
authors.forename: Charrell M
authors.initials: CM
authors.lastname: Bullard
authors.forename: Milena H
authors.initials: MH
authors.lastname: Armani
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Miller
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Shaffer