title: In utero transplantation: Disparate ramifications.
abstract: In utero stem cell transplantation, which promises treatment for a host of genetic disorders early in gestation before disease effect stems from Ray Owen's seminal observation that self-tolerance, is acquired during gestation. To date, in utero transplantation (IUT) has proved useful in characterizing the hematopoietic stem cell. Recent observations support its use as an in vivo method to further understanding of self-tolerance. Preclinical development continues for its application as a treatment for childhood hematolymphoid diseases. In addition, IUT may offer therapeutic options in the treatment of diabetes among other diseases. Thus IUT serves as a technique or system important in both a basic and applied format. This review summarizes these findings.
authors.affiliation: John S Pixley, Rheumatology/Immunology Division, Department of Medicine, VA Sierra Health Care System and the University of Nevada School of Medicine, Reno, NV 89557, United States.
authors.forename: John S
authors.initials: JS
authors.lastname: Pixley
authors.forename: Esmail D
authors.initials: ED
authors.lastname: Zanjani
keywords: Immune ontogeny; Self non-self discrimination; Stem cell transplantation