title: Anthropometric, socioeconomic, and maternal health determinants of placental transfer of organochlorine compounds.
abstract: The aim of this study was to relate placental transfer, quantified by the cord to maternal serum concentration ratio (C/M), of five organochlorine pesticides (OCP) hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), γ-hexachlorocyclohexane (γ-HCH) , p,p'-DDT, p,p'-DDE and 15 polychlorinated biphenyl (PCB) congeners (28, 52, 101, 105, 114, 118, 123(+149), 138(+163), 153, 156(+171), 157, 167, 170, 180, and 189) to anthropometric, socioeconomic, and maternal health characteristics. We included into the study 1,134 births during the period 2002-2004 from two districts in eastern Slovakia with high organochlorine concentrations relative to other areas of the world. Only concentrations >LOD were taken into account. Variables as age, weight and height of mothers, parity, ethnicity, alcohol consumption, illness during pregnancy, smoking during pregnancy, hypertension, respiratory diseases, rheumatoid arthritis and diabetes mellitus, and birth weight were related to C/M. Results of regression analyses showed that C/M was predicted by several factors studied. Positive associations were observed for gestational alcohol consumption, fewer illnesses during pregnancy, maternal age, and maternal weight. Caucasians had a greater C/M compared to Romani for wet weight data of congeners 170 and 180 and in contrast C/M for HCB was greater in Romani. Our results show that drinking mothers compared to abstaining expose their fetuses not only to alcohol but to an increased level of several PCB congeners. A straightforward explanation of associations between C/M shifts and factors studied is very difficult, however, with regard to the high lipophilicity of OCPs and PCBs, changes in their kinetics probably reflect lipid kinetics.
authors.affiliation: Department of Environmental Medicine, Slovak Medical University, Limbová 12, 83303, Bratislava, Slovakia.
authors.forename: Henrieta
authors.initials: H
authors.lastname: Patayová
authors.forename: Soňa
authors.initials: S
authors.lastname: Wimmerová
authors.forename: Kinga
authors.initials: K
authors.lastname: Lancz
authors.forename: L'ubica
authors.initials: L
authors.lastname: Palkovičová
authors.forename: Beata
authors.initials: B
authors.lastname: Drobná
authors.forename: Anna
authors.initials: A
authors.lastname: Fabišiková
authors.forename: Ján
authors.initials: J
authors.lastname: Kováč
authors.forename: Irva
authors.initials: I
authors.lastname: Hertz-Picciotto
authors.forename: Todd A
authors.initials: TA
authors.lastname: Jusko
authors.forename: Tomáš
authors.initials: T
authors.lastname: Trnovec
mesh_terms: D000328:Adult; D003634:DDT / Q000097:blood; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006581:Hexachlorobenzene / Q000097:blood; D001556:Hexachlorocyclohexane / Q000097:blood; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D008297:Male; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D008429:Maternal Welfare / Q000706:statistics & numerical data*; D010575:Pesticides / Q000097:blood; D010920:Placenta / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000097:blood; D011247:Pregnancy; D018154:Slovakia; D012959:Socioeconomic Factors; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D003633:Dichlorodiphenyl Dichloroethylene; D006581:Hexachlorobenzene; D001556:Hexachlorocyclohexane; D003634:DDT; D011078:Polychlorinated Biphenyls; C023888:beta-hexachlorocyclohexane