title: Ventricular enlargement and its clinical correlates in the imaging cohort from the ADCS MCI donepezil/vitamin E study.
abstract: We analyzed the baseline and 3-year T1-weighted magnetic resonance imaging data of 110 amnestic mild cognitive impairment (MCI) participants with minimal hippocampal atrophy at baseline from the Alzheimer's Disease Cooperative Study group MCI Donepezil/Vitamin E trial. Forty-six subjects converted to Alzheimer disease (AD) (MCIc), whereas 64 remained stable (MCInc). We used the radial distance technique to examine the differences in lateral ventricle shape and size between MCIc and MCInc and the associations between ventricular enlargement and cognitive decline. MCIc group had significantly larger frontal and right body/occipital horns relative to MCInc at baseline and significantly larger bilateral frontal, body/occipital, and left temporal horns at follow-up. Global cognitive decline measured with AD Assessment scale cognitive subscale and Mini-Mental State Examination and decline in activities of daily living (ADL) were associated with posterior lateral ventricle enlargement. Decline in AD Assessment scale cognitive subscale and ADL were associated with left temporal and decline in Mini-Mental State Examination with right temporal horn enlargement. After correction for baseline hippocampal volume, decline in ADL showed a significant association with right frontal horn enlargement. Executive decline was associated with right frontal and left temporal horn enlargement.
authors.affiliation: Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA. lapostolova@mednet.ucla.edu
authors.forename: Liana G
authors.initials: LG
authors.lastname: Apostolova
authors.forename: Sona
authors.initials: S
authors.lastname: Babakchanian
authors.forename: Kristy S
authors.initials: KS
authors.lastname: Hwang
authors.forename: Amity E
authors.initials: AE
authors.lastname: Green
authors.forename: Dimitar
authors.initials: D
authors.lastname: Zlatev
authors.forename: Yi-Yu
authors.initials: YY
authors.lastname: Chou
authors.forename: Charlie
authors.initials: C
authors.lastname: DeCarli
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.forename: Paul S
authors.initials: PS
authors.lastname: Aisen
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Cummings
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Toga
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology* / Q000517:prevention & control; D002552:Cerebral Ventricles / Q000473:pathology*; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage*; D060825:Cognitive Dysfunction / Q000188:drug therapy / Q000473:pathology*; D018450:Disease Progression; D000077265:Donepezil; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007189:Indans / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging; D008297:Male; D010880:Piperidines / Q000008:administration & dosage*; D014810:Vitamin E / Q000008:administration & dosage*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D014815:Vitamins; D014810:Vitamin E; D000077265:Donepezil