title: Immune-suppressive properties of the tumor microenvironment.
abstract: Solid tumors are more than an accumulation of cancer cells. Indeed, cancerous cells create a permissive microenvironment by exploiting non-transformed host cells. Thus, solid tumors rather resemble abnormal organs composed of the cancerous cells itself and the stroma providing the supportive framework. The stroma can be divided into the extracellular matrix consisting of proteoglycans, hyaluronic acid, and fibrous proteins, as well as stromal cells including mesenchymal and immune cells; moreover, it contains various peptide factors and metabolites. Here, we will focus on immune-modulating capacities of the tumor microenvironment.
authors.affiliation: Department of General Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8010, Graz, Austria. juergen.becker@medunigraz.at
authors.forename: Jürgen C
authors.initials: JC
authors.lastname: Becker
authors.forename: Mads Hald
authors.initials: MH
authors.lastname: Andersen
authors.forename: David
authors.initials: D
authors.lastname: Schrama
authors.forename: Per
authors.initials: P
authors.lastname: Thor Straten
mesh_terms: D001119:Arginase / Q000378:metabolism; D015687:Cell Hypoxia; D005109:Extracellular Matrix; D006801:Humans; D007108:Immune Tolerance; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000096:biosynthesis / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology*; D009389:Neovascularization, Pathologic / Q000378:metabolism; D017154:Stromal Cells / Q000378:metabolism; D014366:Tryptophan Oxygenase / Q000378:metabolism; D059016:Tumor Microenvironment / Q000276:immunology*
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; C527085:KLRK1 protein, human; D055655:NK Cell Lectin-Like Receptor Subfamily K; D014366:Tryptophan Oxygenase; D001119:Arginase