title: NSAIDs can have adverse effects on bone healing.
abstract: The science of osteoimmunology, a relatively new field of research, reveals the important interactions between the immune system and skeletal system. Interactions occur between prostaglandin metabolism, inflammatory proteins and bone metabolism. Systemic as well as local sources of inflammation appear to be actively involved in both bone formation and resorption. Non Steroidal Anti-Inflammatory Drugs (NSAIDs) can play a detrimental role in bone fractures, opposing the aim of the intervention, and can have such a negative impact on the synthesis of prostaglandins that they could even promote bone resorption. When used for a prolonged time, NSAIDs can also cause the development of an inflammatory cascade starting from the gastro-intestinal system, possibly resulting in bone resorption. Several studies show that the use of either selective or non-selective NSAIDs are intimately related to disturbances in immunological allostasis, bone metabolism and the inhibition or impediment of bone healing.
authors.affiliation: University of Girona, C Francesc MaciÃ 65, 17190 Salt, Girona, Spain. robert@triastotaal.nl
authors.forename: Robert W
authors.initials: RW
authors.lastname: van Esch
authors.forename: Maurice M
authors.initials: MM
authors.lastname: Kool
authors.forename: Saskia
authors.initials: S
authors.lastname: van As
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D017102:Fracture Healing / Q000187:drug effects*; D006801:Humans; D008962:Models, Theoretical
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal