title: Coumarin chalcone fibrates: a new structural class of lipid lowering agents.
abstract: In our continuing search for safe and efficacious antidyslipidemic agents, structurally interesting coumarin-chalcone fibrates were synthesized and evaluated in triton WR-1339 induced hyperlipidemic rats. The most active compound 41 decreased the total cholesterol (TC), phospholipids (PL) and triglycerides (TG), of hyperlipidemic rats by 26, 24, and 25% respectively. In addition, the compound 41 significantly reversed the levels of VLDL, LDL HDL and also increased the LPL activity. Altogether, our data suggests that these novel hybrids would be a potential new class of therapeutic agents against dyslipidemia.
authors.affiliation: Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India. sashidhar123@gmail.com
authors.forename: Koneni V
authors.initials: KV
authors.lastname: Sashidhara
authors.forename: Gopala Reddy
authors.initials: GR
authors.lastname: Palnati
authors.forename: Ravi
authors.initials: R
authors.lastname: Sonkar
authors.forename: Srinivasa Rao
authors.initials: SR
authors.lastname: Avula
authors.forename: Chetan
authors.initials: C
authors.lastname: Awasthi
authors.forename: Gitika
authors.initials: G
authors.lastname: Bhatia
mesh_terms: D000818:Animals; D047188:Chalcones / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D050171:Dyslipidemias / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D015394:Molecular Structure; D011092:Polyethylene Glycols; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D047188:Chalcones; D003374:Coumarins; D011092:Polyethylene Glycols; C016811:tyloxapol