title: Multifunctional Fe3O4@P(St/MAA)@chitosan@Au core/shell nanoparticles for dual imaging and photothermal therapy.
abstract: Merging different components into a single nanoparticle can exhibit profound impact on various biomedical applications including diagnostics, imaging, and therapy. However, retaining the unique properties of each component after integration has proven to be a significant challenge. Our previous research demonstrated that gold nanoshells on polystyrene spheres have potential in photohermal therapy. Here, we report a facile and green strategy to synthesize a multifunctional nanocomposite with Fe3O4 core coated gold nanoshells as dual imaging probes and photothermal agents. The as-prepared nanoparticles exhibit well-defined structure and excellent physical properties such as magnetic and plasmonic activities. Therefore, they were applied as contrast agents in magnetic resonance imaging (MRI) and dark field imaging (DFI). Besides, we demonstrated their potential application in photothermal therapy. Moreover, the obtained multifunctional nanoparticles have shown excellent biocompatibility for their low cytotoxicity and hemolyticity.
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Xuandong
authors.initials: X
authors.lastname: Wang
authors.forename: Huiyu
authors.initials: H
authors.lastname: Liu
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.forename: Xianwei
authors.initials: X
authors.lastname: Meng
authors.forename: Tianlong
authors.initials: T
authors.lastname: Liu
authors.forename: Changhui
authors.initials: C
authors.lastname: Fu
authors.forename: Nanjing
authors.initials: N
authors.lastname: Hao
authors.forename: Yanqi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wu
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
authors.forename: Fangqiong
authors.initials: F
authors.lastname: Tang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D005354:Fibrosarcoma; D006046:Gold / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D010789:Phototherapy / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D006046:Gold; D048271:Chitosan; D052203:Ferrosoferric Oxide