title: Regulation of cytoskeletal dynamics by phospholipase D and phosphatidic acid.
abstract: Plants respond to diverse biotic and abiotic stimuli as well as to endogenous developmental cues. Many of these stimuli result in altered activity of phospholipase D (PLD), an enzyme that hydrolyzes structural phospholipids producing phosphatidic acid (PA). PA is a key signaling intermediate in animals, but its targets in plants are relatively uncharacterized. Recent studies have demonstrated that the cytoskeleton is a major target of PLD-PA signaling and identified a positive feedback loop between actin turnover and PLD activity. Moreover, two cytoskeletal proteins, capping protein and MAP65-1, have been identified as PA-binding proteins regulating actin and microtubule organization and dynamics. In this review, we highlight the role of the PLD-PA module as an important hub for housekeeping and stress-induced regulation of membrane-associated cytoskeletal dynamics.
authors.affiliation: Institute of Experimental Botany v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.
authors.forename: Roman
authors.initials: R
authors.lastname: Pleskot
authors.forename: Jiejie
authors.initials: J
authors.lastname: Li
authors.forename: Viktor
authors.initials: V
authors.lastname: Zárský
authors.forename: Martin
authors.initials: M
authors.lastname: Potocký
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Staiger
mesh_terms: D000199:Actins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D010712:Phosphatidic Acids / Q000378:metabolism*; D010739:Phospholipase D / Q000378:metabolism*; D018521:Plant Physiological Phenomena; D010940:Plant Proteins / Q000378:metabolism*; D010944:Plants / Q000201:enzymology*; D011485:Protein Binding; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D000199:Actins; D010712:Phosphatidic Acids; D010940:Plant Proteins; D010739:Phospholipase D
keywords: actin; cytoskeleton; microtubules; phosphatidic acid; phospholipase D; signaling