title: Locked nucleic acid: tighter is different.
abstract: This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first described in a ChemComm paper in 1998. A number of unique applications in oligonucleotide biotechnology have been made possible by the high binding affinity and specificity of LNA, and these provide the main focus of the viewpoint.
authors.affiliation: Department of Chemistry and Institute for Life Sciences, University of Southampton, SO17 1BJ, UK. j.k.watts@soton.ac.uk
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Watts
mesh_terms: D000818:Animals; D004247:DNA / Q000378:metabolism; D020868:Gene Silencing; D006801:Humans; D009841:Oligonucleotides / Q000737:chemistry* / Q000378:metabolism; D012313:RNA / Q000378:metabolism
chemical_list: D009841:Oligonucleotides; C477371:locked nucleic acid; D012313:RNA; D004247:DNA