title: Breast image analysis for risk assessment, detection, diagnosis, and treatment of cancer.
abstract: The role of breast image analysis in radiologists' interpretation tasks in cancer risk assessment, detection, diagnosis, and treatment continues to expand. Breast image analysis methods include segmentation, feature extraction techniques, classifier design, biomechanical modeling, image registration, motion correction, and rigorous methods of evaluation. We present a review of the current status of these task-based image analysis methods, which are being developed for the various image acquisition modalities of mammography, tomosynthesis, computed tomography, ultrasound, and magnetic resonance imaging. Depending on the task, image-based biomarkers from such quantitative image analysis may include morphological, textural, and kinetic characteristics and may depend on accurate modeling and registration of the breast images. We conclude with a discussion of future directions.
authors.affiliation: Department of Radiology, University of Chicago, Chicago, IL 60637, USA. m-giger@uchicago.edu
authors.forename: Maryellen L
authors.initials: ML
authors.lastname: Giger
authors.forename: Nico
authors.initials: N
authors.lastname: Karssemeijer
authors.forename: Julia A
authors.initials: JA
authors.lastname: Schnabel
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D014408:Biomarkers, Tumor; D001696:Biomechanical Phenomena; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007700:Kinetics; D008327:Mammography / Q000379:methods; D009038:Motion; D064847:Multimodal Imaging / Q000379:methods; D010641:Phenotype; D011857:Radiographic Image Interpretation, Computer-Assisted; D012306:Risk; D018570:Risk Assessment
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor