title: Radical vaginal trachelectomy: a fertility-preserving procedure in early cervical cancer in young women.
abstract: BACKGROUND
  Radical vaginal trachelectomy (RVT) is a fertility-preserving operation for young women who have cervical cancer in an early stage and want to have children. The demand for RVT is increasing, because more than 40% of all cases of cervical carcinoma affect women under the age of 44. Women are increasingly having their first child at later ages.
  
  
  METHODS
  We present the results of RVT in more than 300 patients whom we operated on, review pertinent literature retrieved by a selective PubMed search, and evaluate treatment recommendations.
  
  
  RESULTS
  The literature contains data on more than 1000 women treated with RVT and nearly 300 pregnancies after RVT. The 5-year recurrence and mortality rates are 2%-5% and 3%-6%, respectively. RVT is an oncologically safe treatment for women who want to have children. The main criteria for treatment with RVT are that the tumor should be no greater than 2 cm in diameter and that the lymph nodes should be histopathologically free of tumor tissue. The laparoscopic-vaginal technique is the best operative approach to assure a high rate of healing. Only one-third of all patients want to have children a short time after RVT. Their pregnancy rates resemble those of women in the general population. 50% of the children are born prematurely, mainly because of premature rupture of the membranes. Thus, pregnancies after RVT are considered high-risk pregnancies.
  
  
  CONCLUSIONS
  As many as 48% of women with early-stage cervical carcinoma meet the criteria for RVT. RVT is an oncologically safe method that enables women with early-stage cervical carcinoma to become pregnant and have children. Pregnancy after RVT is associated with an elevated risk of preterm birth and should be managed according to standardized procedures.
authors.affiliation: Department of Gynecology and Gynecological Oncology including Breast Center, Charité-Universitätsmedizin Berlin, Germany. dorothee.speiser@charite.de
authors.forename: Dorothee
authors.initials: D
authors.lastname: Speiser
authors.forename: Christhardt
authors.initials: C
authors.lastname: Köhler
authors.forename: Achim
authors.initials: A
authors.lastname: Schneider
authors.forename: Mandy
authors.initials: M
authors.lastname: Mangler
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007045:Hysterectomy, Vaginal / Q000379:methods* / Q000401:mortality*; D007247:Infertility, Female / Q000401:mortality* / Q000517:prevention & control*; D008875:Middle Aged; D059351:Organ Sparing Treatments / Q000401:mortality; D011183:Postoperative Complications / Q000401:mortality*; D011247:Pregnancy; D018873:Pregnancy Rate; D018570:Risk Assessment; D015996:Survival Rate; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000601:surgery*; D055815:Young Adult