title: A new bioactive sesquiterpenoid quinone from the Mediterranean Sea marine sponge Dysidea avara.
abstract: Investigation of the marine sponge Dysidea avara, family Dysideidae, afforded a new sesquiterpene (-)-N-methylmelemeleone-A (5), in addition to four known sesquiterpenes (+)-avarol (1), (+)-avarone (2), (-)-3'-methylaminoavarone (3) and (-)-4'-methylaminoavarone (4). The structure elucidation of compound 5 was based on 1D and 2D NMR spectroscopic, and HR-MS studies, as well as by comparison with the literature. Cytotoxicity, proteinkinase inhibition, inhibition of NFkB-activity and insecticidal activity were evaluated for the isolated compounds.
authors.affiliation: Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität, Universitätsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany.
authors.forename: Ashraf Nageeb El-Sayed
authors.initials: AN
authors.lastname: Hamed
authors.forename: Wim
authors.initials: W
authors.lastname: Wätjen
authors.forename: Roland
authors.initials: R
authors.lastname: Schmitz
authors.forename: Yvonni
authors.initials: Y
authors.lastname: Chovolou
authors.forename: RuAngelie
authors.initials: R
authors.lastname: Edrada-Ebel
authors.forename: Diaa T A
authors.initials: DT
authors.lastname: Youssef
authors.forename: Mohammed Salah
authors.initials: MS
authors.lastname: Kamel
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D047088:Dysidea / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008522:Mediterranean Sea; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D012717:Sesquiterpenes