title: The effect of whole body vibration exposure on muscle function in children with cystic fibrosis: a pilot efficacy trial.
abstract: BACKGROUND
  To examine the effects of whole body vibration (WBV) exposure on muscle function in children with Cystic Fibrosis (CF). Non-randomised controlled cross-over trial.
  
  
  METHODS
  The setting was home-based WBV exposure. The participants were children (8 - 15 years) with CF (n = 7).
  
  
  METHODS
  participants served as their own controls for the first four weeks (usual care), then underwent four weeks of parentally-supervised home-based WBV exposure followed by four weeks washout (usual care). The WBV exposure consisted of 20 - 30 minutes of intermittent (1 min vibration:1 min rest) exposure on a Galileo platform (20 - 22Hz, 1 mm amplitude) 3 days/week. The primary outcome measures of absolute and relative lower body (leg extension (LE), leg press (LP)), upper body (chess press (CP)) strength and power, and power were measured at baseline, and weeks 4, 8 and 12. Secondary exploratory outcomes were cardiorespiratory fitness, pulmonary function and health-related quality of life.
  
  
  RESULTS
  Six participants completed the training without adverse events. Muscle function changes following WBV exposure were not statistically significant. However, moderate-to-large relative effect sizes (ES) favouring WBV were evident for leg extension strength (ES = 0.66 (-0.50, 1.82)), LP relative strength (ES = 0.92 (-0.27, 2.11)), leg press peak power (ES = 0.78 (-0.50, 2.07)) and CMJ height (ES = 0.60 (-0.56 to 1.76)).
  
  
  CONCLUSIONS
  The results from this first controlled trial indicate that WBV may be a potentially effective exercise modality to safely increase leg strength and explosive power in children with CF. Potentially clinically relevant changes support continued investigation of the efficacy, mechanism and feasibility of this intervention in future large-scale studies.
authors.affiliation: Exercise, Health and Performance, Faculty Research Group, Faculty of Health Sciences, University of Sydney, Australia.
authors.forename: Kaitlin
authors.initials: K
authors.lastname: O'Keefe
authors.forename: Rhonda
authors.initials: R
authors.lastname: Orr
authors.forename: Peite
authors.initials: P
authors.lastname: Huang
authors.forename: Hiran
authors.initials: H
authors.lastname: Selvadurai
authors.forename: Peter
authors.initials: P
authors.lastname: Cooper
authors.forename: Craig Frank
authors.initials: CF
authors.lastname: Munns
authors.forename: Maria A Fiatarone
authors.initials: MA
authors.lastname: Singh
keywords: Children; Cystic Fibrosis; Muscle function; Muscle power; Vibration