title: In vitro and in vivo evaluation of the antitumor efficiency of resveratrol against lung cancer.
abstract: Lung cancer remains a deadly disease with unsatisfactory overall survival. Resveratrol (Res) has the potential to inhibit growth of several types of cancer such as prostate and colorectal examples. In the current study, we evaluated in vitro and in vivo anticancer efficiency of Res in a xenograft model with A549 cells. Cell inhibition effects of Res were measured by MTT assay. Apoptotis of A549 cells was assessed with reference to caspase-3 activity and growth curves of tumor volume and bodyweight of the mice were measured every two days. In vitro cytotoxicity evaluation indicated Res to exert dose-dependent cell inhibition effects against A549 cells with activation of caspase-3. In vivo evaluation showed Res to effectively inhibit the growth of lung cancer in a dose- dependent manner in nude mice. Therefore, we believe that Res might be a promising phytomedicine for cancer therapy and further efforts are needed to explore this potential therapeutic strategy.
authors.affiliation: Department of Radiotherapy, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University, Xuzhou, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Yin
authors.forename: Qing-Zhong
authors.initials: QZ
authors.lastname: Tian
authors.forename: Luan
authors.initials: L
authors.lastname: Guan
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhou
authors.forename: Xin-En
authors.initials: XE
authors.lastname: Huang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D047368:Tumor Burden; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; D053148:Caspase 3; D000077185:Resveratrol