title: Direct catalytic asymmetric Mannich-type reaction of α-sulfanyl lactones.
abstract: Catalytic asymmetric Mannich-type reactions of α-sulfanyl lactones to aldimines were promoted by a chiral Ag complex/DBU binary catalyst. The reaction proceeded in a syn-selective manner in high enantioselectivity. Alkylative activation of the sulfide of the Mannich adduct allowed for the formation of trisubstituted aziridines.
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Tokyo, 3-14-23 Kamiosaki, Tokyo 141-0021, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Takechi
authors.forename: Naoya
authors.initials: N
authors.lastname: Kumagai
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Shibasaki
mesh_terms: D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D001388:Aziridines; D007783:Lactones; D013438:Sulfhydryl Compounds