title: Blood stage of Plasmodium vivax in central China is still susceptible to chloroquine plus primaquine combination therapy.
abstract: In central China, Plasmodium vivax accounts for all of the native reported cases of malaria. Chloroquine (CQ) plus primaquine (PQ) have been used for more than 60 years as the frontline drugs, but the risk of treatment failure remains unknown. To measure the effectiveness and safety of CQ-PQ among vivax malaria patients, a total of 39 subjects with monoinfection vivax malaria was enrolled in a study from 2008 to 2009. There were no recrudescence or danger signs observed within the 28-day follow-up period, showing that blood stage of P. vivax isolates from central China is still susceptible to CQ plus PQ combination therapy. However, the antirelapse efficacy of PQ is difficult to assess because of the high rate of loss to follow-up after 28 days; also, parasites persisted in a single case at 3 days post-antimalarial drug treatment, indicating that continuous annual monitoring is needed in central China.
authors.affiliation: Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, People's Republic of China
authors.forename: Guoding
authors.initials: G
authors.lastname: Zhu
authors.forename: Feng
authors.initials: F
authors.lastname: Lu
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
authors.forename: Huayun
authors.initials: H
authors.lastname: Zhou
authors.forename: Yaobao
authors.initials: Y
authors.lastname: Liu
authors.forename: Eun-Taek
authors.initials: ET
authors.lastname: Han
authors.forename: Qi
authors.initials: Q
authors.lastname: Gao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D002738:Chloroquine / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D016780:Malaria, Vivax / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010966:Plasmodium vivax / Q000187:drug effects; D011319:Primaquine / Q000008:administration & dosage / Q000627:therapeutic use*; D018571:Sentinel Surveillance; D055815:Young Adult
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D011319:Primaquine