title: Mitochondrial and skeletal muscle health with advancing age.
abstract: With increasing age there is a temporal relationship between the decline of mitochondrial and skeletal muscle volume, quality and function (i.e., health). Reduced mitochondrial mRNA expression, protein abundance, and protein synthesis rates appear to promote the decline of mitochondrial protein quality and function. Decreased mitochondrial function is suspected to impede energy demanding processes such as skeletal muscle protein turnover, which is critical for maintaining protein quality and thus skeletal muscle health with advancing age. The focus of this review was to discuss promising human physiological systems underpinning the decline of mitochondrial and skeletal muscle health with advancing age while highlighting therapeutic strategies such as aerobic exercise and caloric restriction for combating age-related functional impairments.
authors.affiliation: Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota, United States.
authors.forename: Adam R
authors.initials: AR
authors.lastname: Konopka
authors.forename: K
authors.initials: K
authors.lastname: Sreekumaran Nair
mesh_terms: D000375:Aging / Q000502:physiology*; D000975:Antioxidants / Q000378:metabolism; D001842:Bone and Bones / Q000502:physiology; D031204:Caloric Restriction; D015444:Exercise / Q000502:physiology; D006801:Humans; D008931:Mitochondria, Muscle / Q000378:metabolism / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D012333:RNA, Messenger / Q000096:biosynthesis; D000077278:RNA, Mitochondrial; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; D000077278:RNA, Mitochondrial; D017382:Reactive Oxygen Species; C029305:mitochondrial messenger RNA
keywords: Aging; Mitochondria; Protein metabolism; Sarcopenia