title: Analysis of genetic variants of dyslexia candidate genes KIAA0319 and DCDC2 in Indian population.
abstract: Developmental dyslexia (DD) is a heritable, complex genetic disorder associated with impairment in reading and writing skills despite having normal intellectual ability and appropriate educational opportunities. Chromosome 6p23-21.3 at DYX2 locus has showed the most consistent evidence of linkage for DD and two susceptible genes KIAA0319 and DCDC2 for DD at DYX2 locus showed significant association. Specific candidate gene-association studies have identified variants, risk haplotypes and microsatellites of KIAA0319 and DCDC2 correlated with wide range of reading-related traits. In this study, we used a case-control approach for analyzing single-nucleotide polymorphisms (SNPs) in KIAA0319 and DCDC2. Our study demonstrated the association of DD with SNP rs4504469 of KIAA0319 and not with any SNPs of DCDC2.
authors.affiliation: Genetics and Genomics Laboratory, Department of Studies in Zoology, University of Mysore, Mysore, India.
authors.forename: Shyamala K
authors.initials: SK
authors.lastname: Venkatesh
authors.forename: Anand
authors.initials: A
authors.lastname: Siddaiah
authors.forename: Prakash
authors.initials: P
authors.lastname: Padakannaya
authors.forename: Nallur B
authors.initials: NB
authors.lastname: Ramachandra
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002675:Child, Preschool; D004410:Dyslexia / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D007194:India; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D008957:Models, Genetic; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide; D011932:Reading
chemical_list: C510451:DCDC2 protein, human; C500377:KIAA0319 protein, human; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins