title: Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection.
abstract: The objective of the study was to investigate the clinical significance of CKAP4 in intrahepatic cholangiocellular carcinoma (ICC). CKAP4 expression was determined in a cohort containing 173 cases of ICC patients. We found that CKAP4 was overexpressed in the majority of ICC cases and was significantly associated with tumor size, distant metastasis, lymph node metastasis, UICC and TNM stage features. Kaplan-Meier and Cox regression data indicated that CKAP4 was correlated with favorable clinical outcome and was an independent predictor for overall survival (HR, 0.646; 95% CI, 0.463-0.900 [p=0.010]). Thus, CKAP4 may serve as a prognostic marker of ICC patients.
authors.affiliation: International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, The Second Military Medical University, Shanghai, PR China.
authors.forename: Min-hong
authors.initials: MH
authors.lastname: Li
authors.forename: Li-wei
authors.initials: LW
authors.lastname: Dong
authors.forename: Shuang-xi
authors.initials: SX
authors.lastname: Li
authors.forename: Gu-sheng
authors.initials: GS
authors.lastname: Tang
authors.forename: Yu-fei
authors.initials: YF
authors.lastname: Pan
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Hua-bang
authors.initials: HB
authors.lastname: Zhou
authors.forename: Ye-xiong
authors.initials: YX
authors.lastname: Tan
authors.forename: He-ping
authors.initials: HP
authors.lastname: Hu
authors.forename: Hong-yang
authors.initials: HY
authors.lastname: Wang
mesh_terms: D001650:Bile Duct Neoplasms; D001653:Bile Ducts, Intrahepatic; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D016009:Chi-Square Distribution; D018281:Cholangiocarcinoma / Q000737:chemistry / Q000235:genetics / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000737:chemistry / Q000235:genetics / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D008565:Membrane Proteins / Q000032:analysis* / Q000235:genetics; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012333:RNA, Messenger / Q000032:analysis; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C081876:CKAP4 protein, human; D008565:Membrane Proteins; D012333:RNA, Messenger
keywords: CKAP4; Disease-free survival; Intrahepatic cholangiocellular carcinomas; Overall survival; Prognosis