title: [Progress of studies in 20-hydroxyeicosatetraenoic acid on vascular endothelium].
abstract: 20-Hydroxyeicosatetraenoic acid (20-HETE) is an important metabolite of cytochrome P-450 pathway of arachidonic acid (AA). It has been demonstrated recently that 20-HETE played a significant role in physiology and pathophysiology process of vascular endothelium (EC). 20-HETE exerted oxidative stress and pro-inflammation effect through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system and nuclear factor-kappaB (NF-kappaB) pathway; it took part in the modulation of vascular dilation and constriction by mediating dissociation of endothelial nitric oxide synthase (eNOS) and inducing angiotensin converting enzyme in EC; it also promoted the proliferation of EC and angiogenesis. However, the domestic study about 20-HETE is rare. Therefore, the present paper reviewed the recent international studies of 20-HETE on EC.
authors.affiliation: Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000502:physiology*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D014666:Vasomotor System / Q000502:physiology*
chemical_list: D006893:Hydroxyeicosatetraenoic Acids; C055987:20-hydroxy-5,8,11,14-eicosatetraenoic acid