title: TGFβ1 microenvironment determines dendritic cell development.
abstract: We have recently described two types of Langerhans cells (LCs), which develop via separate pathways in steady-state conditions and during inflammation. Here, we propose that these two types of LCs differ in their requirement for transforming growth factor β1 (TGFβ1), and we discuss how TGFβ1 impacts on the development of other dendritic cell subtypes.
authors.affiliation: Institute for Biomedical Engineering; Department of Cell Biology; RWTH Aachen University Medical School; Aachen, Germany ; Helmholtz Institute for Biomedical Engineering; RWTH Aachen University; Aachen, Germany.
authors.forename: Kristin
authors.initials: K
authors.lastname: Seré
authors.forename: Piritta
authors.initials: P
authors.lastname: Felker
authors.forename: Thomas
authors.initials: T
authors.lastname: Hieronymus
authors.forename: Martin
authors.initials: M
authors.lastname: Zenke
keywords: Id2; Langerhans cells; TGFβ1; cell differentiation; dendritic cells