title: Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study.
abstract: Pilot studies have indicated that peroral endoscopic myotomy (POEM) might be a safe and effective treatment for achalasia. We performed a prospective, international, multicenter study to determine the outcomes of 70 patients who underwent POEM at 5 centers in Europe and North America. Three months after POEM, 97% of patients were in symptom remission (95% confidence interval, 89%-99%); symptom scores were reduced from 7 to 1 (P < .001) and lower esophageal sphincter pressures were reduced from 28 to 9 mm Hg (P < .001). The percentage of patients in symptom remission at 6 and 12 months was 89% and 82%, respectively. POEM was found to be an effective treatment for achalasia after a mean follow-up period of 10 months.
authors.affiliation: Department of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany. renteln@gmx.net
authors.forename: Daniel
authors.initials: D
authors.lastname: Von Renteln
authors.forename: Karl-Hermann
authors.initials: KH
authors.lastname: Fuchs
authors.forename: Paul
authors.initials: P
authors.lastname: Fockens
authors.forename: Peter
authors.initials: P
authors.lastname: Bauerfeind
authors.forename: Melina C
authors.initials: MC
authors.lastname: Vassiliou
authors.forename: Yuki B
authors.initials: YB
authors.lastname: Werner
authors.forename: Gerald
authors.initials: G
authors.lastname: Fried
authors.forename: Wolfram
authors.initials: W
authors.lastname: Breithaupt
authors.forename: Henriette
authors.initials: H
authors.lastname: Heinrich
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Bredenoord
authors.forename: Jan F
authors.initials: JF
authors.lastname: Kersten
authors.forename: Tessa
authors.initials: T
authors.lastname: Verlaan
authors.forename: Michael
authors.initials: M
authors.lastname: Trevisonno
authors.forename: Thomas
authors.initials: T
authors.lastname: Rösch
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004931:Esophageal Achalasia / Q000601:surgery*; D004945:Esophagoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D057605:Natural Orifice Endoscopic Surgery; D011446:Prospective Studies; D016896:Treatment Outcome
keywords: BTI; EBD; Endoscopic Therapy; Esophageal Motility Disorder; LES; LHM; POEM; PPI; Peroral Endoscopic Myotomy; botulinum toxin injection; endoscopic balloon dilatation; laparoscopic Heller myotomy; lower esophageal sphincter; peroral endoscopic myotomy; proton pump inhibitor