title: Pharmacoeconomics of hematopoietic stem cell mobilization: an overview of current evidence and gaps in the literature.
abstract: Adequate hematopoietic stem cell (HSC) mobilization and collection is required prior to proceeding with high dose chemotherapy and autologous hematopoietic stem cell transplant. Cytokines such as G-CSF, GM-CSF, and peg-filgrastim, alone or in combination with plerixafor, and after chemotherapy have been used to mobilize HSCs. Studies have shown that the efficiency of HSC mobilization and collection may vary when different methods of mobilization are used. No studies have shown that survival is significantly affected by the method of mobilization, but some studies have suggested that cost and resource utilization may be different between different mobilization techniques. After the FDA approval of plerixafor with G-CSF to mobilize HSCs many transplant centers became concerned about the cost of HSC mobilization. A panel of experts was convened ant this paper reviews the current literature on the pharmacoeconomics of HSC mobilization.
authors.affiliation: Texas Transplant Institute, San Antonio, Texas, USA. Paul.Shaughnessy@MHShealth.com
authors.forename: Paul
authors.initials: P
authors.lastname: Shaughnessy
authors.forename: Nelson
authors.initials: N
authors.lastname: Chao
authors.forename: Jamie
authors.initials: J
authors.lastname: Shapiro
authors.forename: Kent
authors.initials: K
authors.lastname: Walters
authors.forename: John
authors.initials: J
authors.lastname: McCarty
authors.forename: Sunil
authors.initials: S
authors.lastname: Abhyankar
authors.forename: Sepideh
authors.initials: S
authors.lastname: Shayani
authors.forename: Pieter
authors.initials: P
authors.lastname: Helmons
authors.forename: Helen
authors.initials: H
authors.lastname: Leather
authors.forename: Amy
authors.initials: A
authors.lastname: Pazzalia
authors.forename: Simon
authors.initials: S
authors.lastname: Pickard
mesh_terms: D017850:Economics, Pharmaceutical; D019650:Hematopoietic Stem Cell Mobilization / Q000191:economics* / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation / Q000191:economics* / Q000379:methods; D006801:Humans
keywords: Autologous; Costs; Failure to mobilize; Mobilization; Pharmacoeconomics; Plerixafor