title: High rates of metachronous colon cancer or dysplasia after segmental resection or subtotal colectomy in Crohn's colitis.
abstract: BACKGROUND
  In ulcerative colitis, total proctocolectomy is the treatment of choice for patients with colonic dysplasia or cancer because of the high risk for metachronous neoplasia. It is unknown whether patients with Crohn's disease and colon cancer or dysplasia have a similar risk.
  
  
  METHODS
  We retrospectively reviewed the charts of 75 patients treated at our center from 2001 to 2011 with Crohn's disease and colon cancer who underwent segmental resection or subtotal colectomy (STC). We then identified the presence or absence of subsequent colon cancer or dysplasia in these patients during the follow-up (0-19 years).
  
  
  RESULTS
  Of the 64 patients with colon cancer, 25 had at least 1 metachronous cancer (39%). The mean time to a new cancer was 6.8 years. Eighty-five percent of patients (21/25) were undergoing annual screening colonoscopy. Of the 11 patients with dysplasia, 5 (46%) had a new dysplasia. Mean time to a new dysplastic lesion was 5.0 years. Nineteen of the 47 patients (40%) who had a segmental resection for colon cancer developed metachronous cancer and 6/17 patients (35%) with a STC had metachronous cancer. Two of the 4 patients (50%) with STC for dysplasia (50%) had a new dysplasia and 3/7 patients (43%) with segmental resection had a new dysplasia. There was no significant difference (P = 0.61) between recurrence rates in patients with segmental resection versus STC.
  
  
  CONCLUSIONS
  The high rate of metachronous colon cancer after surgical resection suggests that total proctocolectomy should be considered. Larger studies are required to determine if the same is true for dysplasia.
authors.affiliation: The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, The Mount Sinai Hospital, New York, NY 10029, USA. elana.maser@mountsinai.org
authors.forename: Elana A
authors.initials: EA
authors.lastname: Maser
authors.forename: David B
authors.initials: DB
authors.lastname: Sachar
authors.forename: Danielle
authors.initials: D
authors.lastname: Kruse
authors.forename: Noam
authors.initials: N
authors.lastname: Harpaz
authors.forename: Thomas
authors.initials: T
authors.lastname: Ullman
authors.forename: Joel J
authors.initials: JJ
authors.lastname: Bauer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D015331:Cohort Studies; D003082:Colectomy / Q000009:adverse effects*; D003092:Colitis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000209:etiology*; D003113:Colonoscopy; D003424:Crohn Disease / Q000150:complications* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000209:etiology*; D011183:Postoperative Complications; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult