title: Relevance of bilateral cervical thymectomy in patients with renal hyperparathyroidism: analysis of 161 patients undergoing reoperative parathyroidectomy.
abstract: BACKGROUND
  The most frequent location of ectopic or supernumerary inferior parathyroid is the thymus. Bilateral cervical thymectomy has therefore been recommended as an essential part of the initial surgery for renal hyperparathyroidism (rHPT) to avoid persistent or recurrent cervical disease. The aim of this study was to evaluate how often reoperation might have been avoidable if an appropriate cervical thymectomy had been performed during initial surgery.
  
  
  METHODS
  A prospective database of patients with rHPT was screened for patients on permanent dialysis who underwent reoperative parathyroidectomy (PTX) between 1976 and 2010. Data were retrospectively analyzed for the performance of bilateral cervical thymectomy during previous surgeries and the presence of ectopic and/or supernumerary intrathymic parathyroid glands during reoperative PTX.
  
  
  RESULTS
  Of 161 patients who underwent reoperative PTX, 95 had neck reexploration. Among them were 29 patients with total PTX and autotransplantation, seven with subtotal PTX (3.5 glands resected), and 59 with incomplete PTX during the initial surgery. Bilateral cervical thymectomy during the initial PTX was performed in only 12 of 95 patients (12.6 %). It was revealed to be incomplete in six of them, inheriting an intrathymic parathyroid gland during reoperative interventions. Reoperative PTX revealed intrathymic parathyroid glands in 27 of 95 patients (28.4 %). The intrathymic parathyroid glands were ectopic in 17 (63.0 %) patients and supernumerary in 8 (29.6 %). Both ectopic and supernumerary intrathymic parathyroid glands were found in two patients (7.4 %).
  
  
  CONCLUSIONS
  The risk for persistent and recurrent disease based on intrathymic parathyroid glands is a relevant problem during initial surgery for rHPT. Thus, routine bilateral cervical thymectomy that is as complete as possible is essential during the initial PTX for rHPT.
authors.affiliation: Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany. ralph.schneider@med.uni-marburg.de
authors.forename: Ralph
authors.initials: R
authors.lastname: Schneider
authors.forename: Detlef K
authors.initials: DK
authors.lastname: Bartsch
authors.forename: Katja
authors.initials: K
authors.lastname: Schlosser
mesh_terms: D002118:Calcium / Q000097:blood; D002828:Choristoma / Q000601:surgery*; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000601:surgery*; D008206:Lymphatic Diseases / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands; D016105:Parathyroidectomy / Q000379:methods*; D012086:Reoperation; D012189:Retrospective Studies; D013934:Thymectomy / Q000379:methods*; D013950:Thymus Gland / Q000601:surgery
chemical_list: D002118:Calcium