title: [Diagnostics and correction of coagulopathy in pregnant women and puerperas with gestosis].
abstract: INTRODUCTION. Gestosis is a complication of normal pregnancy which for long years takes the 2-3rd place in maternal and perinatal mortality and women morbidity structure. 396 patients with moderate and heavy gestosis from 2007 to 2011 were studied. In 53 women (13.4%) it was accompanied by complex haemostasis disturbances and part of women had sepsis. Therefore the retrospective differential analysis of haemostasis disturbances with algorithm presented in this article was carried out. Haemostasis status, complete blood count, biochemical blood analysis data were analyzed. Correction of haemostasis disturbances in the postnatal period was performed according to legacy recommendations. As a result of retrospective differential diagnostics of haemostasis disturbances, the chronic disseminate intravascular clotting (DIC) syndrome, a HELLP-syndrome, thrombotic thrombocytopenic purpura (TTP) and a haemolytic uremic syndrome (HUS) were revealed. The received results indicate that in obstetrics there are essential difficulties with coagulopathy timely diagnostics, especially, TTP and HUS. The most difficult problem is differential diagnostics between a HELLP-syndrome, TTP and HUS. Clear algorithm of differential diagnostics appeared only in 2010. We analyzed all coagulopathy cases since 2007. TTP and HUS were diagnosed by 3rd days of the postnatal period, also specific therapy of these syndromes was late that was reflected in ICU length-of-stay, frequency of sepsis and need of uterectomy respectively.
authors.forename: I B
authors.initials: IB
authors.lastname: Zabolotskikh
authors.forename: G A
authors.initials: GA
authors.lastname: Penzhoian
authors.forename: S V
authors.initials: SV
authors.lastname: Sin'kov
authors.forename: V P
authors.initials: VP
authors.lastname: Muzychenko
authors.forename: I N
authors.initials: IN
authors.lastname: Kapushchenko
mesh_terms: D001778:Blood Coagulation Disorders / Q000097:blood / Q000628:therapy; D016913:Blood Component Transfusion / Q000379:methods; D003422:Critical Care / Q000379:methods*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011644:Puerperal Disorders / Q000097:blood / Q000628:therapy; D012189:Retrospective Studies; D018805:Sepsis / Q000097:blood / Q000628:therapy; D016060:Sorption Detoxification / Q000379:methods; D016896:Treatment Outcome