title: Expression and localization of Luman RNA and protein during mouse implantation and decidualization.
abstract: Luman (also known as LZIP and CREB3) is a basic leucine zipper transcription factor of the cAMP response element-binding protein/activating transcription factor gene family. Although Luman had specific roles near termination of Drosophila embryogenesis, the physiological functions of Luman in female mammals have apparently not been reported. Therefore, our objective was to investigate the spatiotemporal expression and regulation of Luman in the mouse uterus during the peri-implantation period. Luman protein was clearly present in the luminal and glandular epithelium on days 1 to 4 of pregnancy (day 1, presence of a vaginal plug) and was observed in decidual cells on day 6 of pregnancy. Expression had progressively increased to day 7 when the second decidual zone was formed. On day 8, apoptosis of the decidualized cells was present, and Luman protein expression was decreased (in close association with decidualization). Luman protein was also present in decidual cells of the artificially decidualized uterus. The expression of Luman was regulated by an activated embryo (according to its expression patterns during pseudopregnancy and delayed implantation). Furthermore, expression of Luman was induced by estrogen in ovariectomized mice. We have concluded that Luman might have important roles in embryo implantation and decidualization.
authors.affiliation: Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A&F University College of Veterinary Medicine, Yangling, Shaanxi, People's Republic of China.
authors.forename: Xiangli
authors.initials: X
authors.lastname: Lan
authors.forename: Yaping
authors.initials: Y
authors.lastname: Jin
authors.forename: Yanzhou
authors.initials: Y
authors.lastname: Yang
authors.forename: Pengfei
authors.initials: P
authors.lastname: Lin
authors.forename: Linyong
authors.initials: L
authors.lastname: Hu
authors.forename: Chenchen
authors.initials: C
authors.lastname: Cui
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.forename: Aihua
authors.initials: A
authors.lastname: Wang
mesh_terms: D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics* / Q000378:metabolism*; D003656:Decidua / Q000502:physiology*; D010064:Embryo Implantation / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D005865:Gestational Age; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D008297:Male; D051379:Mice; D011247:Pregnancy; D011555:Pseudopregnancy / Q000235:genetics / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: C116472:Creb3 protein, mouse; D017362:Cyclic AMP Response Element-Binding Protein; D012739:Gonadal Steroid Hormones