title: Prediction of individuals prone to suffer from early onset of hypertension.
abstract: The present study was undertaken to predict the persons prone to suffer from early onset of hypertension. Healthy sedentary volunteers (age 18-25 years) having normal blood pressure were asked about their history of familial hypertension, smoking-habit, alcohol consumption, existing worries/anxieties; these being the predisposing factors of hypertension. The blood pressure of them was recorded (casual baseline blood pressure). Maximum voluntary contraction (MVC) was noted as maximum pressure (in Kg) sustained during 3 sec of handgrip using a handgrip dynamometer. Thereafter, the participant was asked to sustain isometric handgrip at one third of MVC for one minute with the same instrument (isometric handgrip-test). Then, blood pressure was measured and the subject was allowed to rest. Three minutes after the handgrip test, the blood pressure was noted again (recovery blood pressure). Handgrip-test produced a rise in systolic blood pressure in all male volunteers. Amongst them, with predisposing factors of hypertension, diastolic blood pressure remained significantly higher than casual baseline diastolic blood pressure even after 3 minutes of withdrawal of stressor. Whereas, in males with no predisposing factors of hypertension, the diastolic blood pressure approached almost the baseline casual blood pressure. In all female participants, no significant difference was noted between the casual baseline blood pressure and blood pressure after recovery. Results indicated that the young men who presented prolonged elevated diastolic blood pressure, in response to handgrip test would be at high risk of early onset of hypertension, as sympathetic over-activity prevails in them for longer time.
authors.affiliation: Department of Physiology, Nepal Medical College, Jorpati, Kathmandu, Nepal.
authors.forename: M T
authors.initials: MT
authors.lastname: Sherpa
authors.forename: R
authors.initials: R
authors.lastname: Shrestha
authors.forename: T
authors.initials: T
authors.lastname: Pramanik
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000503:physiopathology; D001007:Anxiety / Q000503:physiopathology; D001794:Blood Pressure; D005080:Exercise Test; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D011237:Predictive Value of Tests; D012307:Risk Factors; D057185:Sedentary Behavior; D012907:Smoking / Q000503:physiopathology; D055815:Young Adult