title: Antinociceptive and antiallodynic effects of Momordica charantia L. in tibial and sural nerve transection-induced neuropathic pain in rats.
abstract: OBJECTIVE
  This study was designed to investigate the ameliorative potential of Momordica charantia L. (MC) in tibial and sural nerve transection (TST)-induced neuropathic pain in rats.
  
  
  METHODS
  TST was performed by sectioning tibial and sural nerve portions (2 mm) of the sciatic nerve, and leaving the common peroneal nerve intact. Acetone drop, pin-prick, hot plate, paint-brush, and walking track tests were performed to assess cold allodynia, mechanical and heat hyperalgesia, and dynamic mechanical allodynia and tibial functional index, respectively. The levels of tumour necrosis factor (TNF)-alpha and thio-barbituric acid reactive substances (TBARS) were measured in the sciatic nerve as an index of inflammation and oxidative stress. MC (all doses, orally, once daily) was administered to the rats for 24 consecutive days.
  
  
  RESULTS
  TST led to significant development of cold allodynia, mechanical and heat hyperalgesia, dynamic mechanical allodynia, and functional deficit in walking along with rise in the levels of TBARS and TNF-alpha. Administration of MC (200, 400, and 800 mg/kg) significantly attenuated TST-induced behavioural and biochemical changes. Furthermore, pretreatment of BADGE (120 mg/kg, intraperitoneally) abolished the protective effect of MC in TST-induced neuropathic pain.
  
  
  CONCLUSIONS
  Collectively, it is speculated that PPAR-gamma agonistic activity, anti-inflammatory, and antioxidative potential is critical for antinociceptive effect of MC in neuropathic pain.
authors.forename: Vivek
authors.initials: V
authors.lastname: Jain
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Pareek
authors.forename: Nishant
authors.initials: N
authors.lastname: Paliwal
authors.forename: Yashumati
authors.initials: Y
authors.lastname: Ratan
authors.forename: Amteshwar Singh
authors.initials: AS
authors.lastname: Jaggi
authors.forename: Nirmal
authors.initials: N
authors.lastname: Singh
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005260:Female; D006930:Hyperalgesia / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D029777:Momordica charantia / Q000737:chemistry*; D009437:Neuralgia / Q000188:drug therapy* / Q000209:etiology; D018384:Oxidative Stress / Q000187:drug effects; D047495:PPAR gamma / Q000819:agonists; D010147:Pain Measurement; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000737:chemistry; D013497:Sural Nerve / Q000601:surgery; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D013979:Tibial Nerve / Q000601:surgery; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D047495:PPAR gamma; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D014409:Tumor Necrosis Factor-alpha
keywords: BADGE; Inflammation; Momordica charantia L.; Neuropathic pain; PPAR-gamma; TNF-alpha