title: Cell and tissue mechanics in cell migration.
abstract: Migrating cells generate traction forces to counteract the movement-resisting forces arising from cell-internal stresses and matrix adhesions. In the case of collective migration in a cell colony, or in the case of 3-dimensional migration through connective tissue, movement-resisting forces arise also from external stresses. Although the deformation of a stiffer cell or matrix causes larger movement-resisting forces, at the same time a larger stiffness can also promote cell migration due to a feedback between forces, deformations, and deformation speed that is mediated by the acto-myosin contractile machinery of cells. This mechanical feedback is also important for stiffness sensing, durotaxis, plithotaxis, and collective migration in cell colonies.
authors.affiliation: Department of Physics, University of Erlangen-Nuremberg, Erlangen 91052, Germany.
authors.forename: Janina R
authors.initials: JR
authors.lastname: Lange
authors.forename: Ben
authors.initials: B
authors.lastname: Fabry
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D005246:Feedback; D006801:Humans; D040542:Mechanotransduction, Cellular; D032342:Muscle Cells / Q000502:physiology; D009119:Muscle Contraction; D009218:Myosins / Q000378:metabolism*; D013314:Stress, Mechanical
chemical_list: D009218:Myosins
keywords: Acto-myosin interaction; Cell mechanics; Cell migration; Hill-curve; Mechanotransduction; Tissue mechanics