title: Morphological and functional changes in colon after coloplasty for management of corrosive esophageal strictures.
abstract: BACKGROUND
  The etiology of corrosive esophageal strictures is different from that reported in Western literature, with acid ingestion being a major cause. This study evaluated functional and morphological changes in the colon used as neoesophagus.
  
  
  METHODS
  Functional changes in the neoesophagus were evaluated by symptom score of dysphagia and manometry. Barium study and fluoroscopy were done to evaluate the flow patterns and endoscopy with histopathological examination to study the adaptive changes in the colon.
  
  
  RESULTS
  Thirty-five patients with corrosive injury presented between 2007 and 2010. Isolated esophageal involvement was seen in 22 patients; 11 of them underwent colonic replacement. The passage of barium was smooth, without any hold up at the upper or lower anastomotic line. Endoscopic biopsy at 6 months and 1 year did not show any change in the mucosal pattern or in the muscularis layer of the transposed colon. Functional evaluation showed relief of dysphagia in all 11 patients after surgery. The mean preoperative dysphagia score was 7.81 (range 5-10), at 1 month was 0.73 (range 0-2), and at 3 months post-surgery was 0.45 (range 0-2). Manometric study at 3 months after the surgery in all 11 patients and in five patients at the end of 6 months showed no evidence of peristalsis in the neoesophagus. Three of the latter five patients demonstrated a 4-5-cm zone with a high pressure in the intraabdominal part of the transposed colon compared with that in the intrathoracic part of the colon. On barium studies, reflux from the stomach into the neoesophagus was not seen in any of the 11 patients.
  
  
  CONCLUSIONS
  Esophagocoloplasty was associated with symptom relief, and the reflux of gastric content was low because of 4-5 cm of the colon being intraabdominal in a positive pressure environment.
authors.affiliation: Department of Surgical Gastroenterology, K E M Hospital and Seth G S Medical College, Parel, Mumbai 400 012, India. ryprabhu@gmail.com
authors.forename: Ramkrishna
authors.initials: R
authors.lastname: Prabhu
authors.forename: Chetan
authors.initials: C
authors.lastname: Kantharia
authors.forename: Ravi
authors.initials: R
authors.lastname: Bapat
authors.forename: Akash
authors.initials: A
authors.lastname: Shukla
authors.forename: Shobna
authors.initials: S
authors.lastname: Bhatia
authors.forename: Avinash
authors.initials: A
authors.lastname: Supe
mesh_terms: D000293:Adolescent; D000714:Anastomosis, Surgical; D001706:Biopsy; D002057:Burns, Chemical / Q000150:complications* / Q000175:diagnosis; D002648:Child; D003106:Colon / Q000473:pathology / Q000503:physiopathology / Q000637:transplantation*; D016099:Endoscopy, Gastrointestinal; D004940:Esophageal Stenosis / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D004944:Esophagoplasty / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D011446:Prospective Studies; D013270:Stomach / Q000601:surgery; D016896:Treatment Outcome