title: Effect of treatment with atenolol on 5-year survival in cats with preclinical (asymptomatic) hypertrophic cardiomyopathy.
abstract: OBJECTIVE
  To investigate the effect of treatment with atenolol on 5-year survival in cats with preclinical hypertrophic cardiomyopathy (HCM).
  
  
  METHODS
  63 Client-owned cats with preclinical HCM and 31 healthy control cats.
  
  
  METHODS
  Prospective, observational, open-label, clinical cohort study. Cats with HCM were diagnosed by echocardiography, treated with atenolol (6.25-12.5 mg q12h, PO; n = 42) or untreated (n = 21), and were observed for 5 years after enrollment. The study end point was death from any cause. Cats of similar body weight, age, gender, and breed without evidence of heart disease were studied concurrently and served as controls.
  
  
  RESULTS
  During the observational period, 27 cats with HCM died; 14 (22%) due to cardiac disease and 13 (21%) due to non-cardiac disease. Ten control cats (32%) died of non-cardiac disease. There was no significant difference (P = 0.307) in all-cause mortality between control and HCM. Cardiac mortality was higher in cats with HCM compared to control cats (P = 0.005). There was no significant difference in all-cause mortality (P = 0.729) and cardiac mortality (P = 0.897) between cats with HCM treated or untreated with atenolol. Age and left atrial size at diagnosis were the only predictors of 5-year outcome.
  
  
  CONCLUSIONS
  Our study failed to demonstrate an effect of atenolol on 5-year survival in cats with preclinical HCM.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L Tharp Street, Columbus, OH 43210, USA. schober.4@osu.edu
authors.forename: Karsten E
authors.initials: KE
authors.lastname: Schober
authors.forename: Jillian
authors.initials: J
authors.lastname: Zientek
authors.forename: Xiaobai
authors.initials: X
authors.lastname: Li
authors.forename: Virginia Luis
authors.initials: VL
authors.lastname: Fuentes
authors.forename: John D
authors.initials: JD
authors.lastname: Bonagura
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001262:Atenolol / Q000008:administration & dosage / Q000627:therapeutic use*; D002312:Cardiomyopathy, Hypertrophic / Q000188:drug therapy / Q000662:veterinary*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004334:Drug Administration Schedule; D005260:Female; D008297:Male
chemical_list: D000889:Anti-Arrhythmia Agents; D001262:Atenolol