title: Pediatric organ donation and transplantation.
abstract: OBJECTIVE
  There is increasing unmet need for solid organ donation. Alternative donor sources, such as donation after circulatory determination of death (DCDD), are needed. The objective of this study was to examine the impact of DCDD on trends in pediatric organ donation and transplantation.
  
  
  METHODS
  Data were obtained from the Organ Procurement and Transplantation Network for US organ recipients and donors from 2001 to 2010 stratified according to age, organ, and deceased donor type (DCDD or donation after neurologic determination of death). Additional data included transplant wait-list removals due to death.
  
  
  RESULTS
  From 2001 to 2010, pediatric organ transplant recipients increased from 1170 to 1475. Organs from DCDD donors were transplanted into children infrequently but increased from 1 to 31. Pediatric donation after neurologic determination of death decreased by 13% whereas DCDD increased by 174% (50 to 137). Recipients of pediatric grafts decreased from 3042 to 2751. Adults receiving grafts from pediatric donors decreased from 2243 to 1780; children receiving pediatric grafts increased from 799 to 971. Transplant recipients receiving pediatric DCDD grafts were few but increased annually from 50 to 128 adults and 0 to 9 children. Pediatric candidates dying waiting for an organ decreased from 262 to 110.
  
  
  CONCLUSIONS
  From 2001 to 2010, children received more solid organ transplants and fewer children died waiting. Organ recovery from pediatric and adult DCDD donors increased. The number of pediatric recipients of DCDD grafts remains small. Adults primarily receive the direct benefit from pediatric DCDD but other changes in organ allocation have directly benefited children.
authors.affiliation: Pediatric Critical Care Medicine, Salt Lake City, UT 84158, USA. jennifer.workman@hsc.utah.edu
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Workman
authors.forename: Craig W
authors.initials: CW
authors.lastname: Myrick
authors.forename: Rebecka L
authors.initials: RL
authors.lastname: Meyers
authors.forename: Susan L
authors.initials: SL
authors.lastname: Bratton
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Nakagawa
mesh_terms: D000293:Adolescent; D000328:Adult; D001926:Brain Death; D002648:Child; D002675:Child, Preschool; D003643:Death; D006801:Humans; D007223:Infant; D016377:Organ Transplantation / Q000706:statistics & numerical data*; D009927:Tissue and Organ Procurement / Q000706:statistics & numerical data*; D014481:United States
keywords: brain death; circulatory death; end of life; ethics; organ donation; pediatric; transplantation