title: Insulin-like growth factor-1 bioactivity plays a prosurvival role in older participants.
abstract: The aim of this study was to address the intriguing issue of the role of the insulin-like growth factor (IGF)-1 system in longevity looking at the role of different components of IGF system. Vital status was ascertained in 1,197 men and women aged greater than or equal to 65 years from the InCHIANTI study. Hormonal levels were categorized into quartiles, and ratio of IGF-1 to IGF-binding protein (IGFBP)-1 was calculated. The relationship between hormones and mortality was tested by Cox proportional hazard models adjusted for age, sex, and confounders. During the 8-year follow-up period, 240 died and 957 survived. Lowest quartiles of IGF-1 and IGFBP-1 were considered as reference. Compared with the lowest quartiles, IGF-1 in upper quartiles was a negative predictor of mortality independent of age and sex (p = .01) but not independent of IGFBP-1 and other confounders. IGFBP-1 in second-third quartiles was negatively associated and that in the fourth quartiles was positively associated with risk of death. IGF-1/IGFBP-1 ratio in the lowest quartiles was a strong positive predictor of mortality, in age- and sex-adjusted model (p = .005), and independent of additional confounders (p = .037). High IGFBP-1 and low IGF-1/IGFBP-1 ratio are associated with all-cause mortality in older population.
authors.affiliation: Section of Geriatrics, Department of Clinical and Experimental Medicine, University of Parma, via Gramsci 14, 43100 Parma, Italy. marcellomaggio2001@yahoo.it.
authors.forename: Marcello
authors.initials: M
authors.lastname: Maggio
authors.forename: Chiara
authors.initials: C
authors.lastname: Cattabiani
authors.forename: Fulvio
authors.initials: F
authors.lastname: Lauretani
authors.forename: Stefania
authors.initials: S
authors.lastname: Bandinelli
authors.forename: Francesca
authors.initials: F
authors.lastname: De Vita
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Dall'Aglio
authors.forename: Andrea
authors.initials: A
authors.lastname: Corsonello
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Lattanzio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolisso
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Ceda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000401:mortality; D002423:Cause of Death; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000502:physiology*; D008136:Longevity / Q000502:physiology*; D008297:Male; D016016:Proportional Hazards Models
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I
keywords: IGF-1 bioactivity; IGF-binding proteins; Mortality; Older participants.