title: Pharmacokinetics of linezolid in the mediastinum and pleural space.
abstract: The purpose of this study was to investigate the penetration of linezolid into the mediastinum and pleural space by comparing its concentration in the serum, mediastinum, and pleural space. The linezolid area under the concentration-versus-time curve from zero to 12h (AUC)(mediastinum fluid/serum) and AUC(pleural fluid/serum) ratio were 1.32 and 1.64, respectively. The results suggest that the linezolid concentration in the mediastinum varies as in the serum, and that the concentration in the mediastinum is the same as or greater than that in the serum.
authors.affiliation: Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. Electronic address: ytsuji@pha.u-toyama.ac.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Wataru
authors.initials: W
authors.lastname: Hashimoto
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Taniguchi
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiraki
authors.forename: Akiko
authors.initials: A
authors.lastname: Mizoguchi
authors.forename: Eiji
authors.initials: E
authors.lastname: Yukawa
authors.forename: Hideto
authors.initials: H
authors.lastname: To
mesh_terms: D000081:Acetamides / Q000493:pharmacokinetics*; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D045604:Extracellular Fluid / Q000378:metabolism; D006801:Humans; D000069349:Linezolid; D008297:Male; D008480:Mediastinitis / Q000175:diagnosis / Q000378:metabolism / Q000382:microbiology; D008482:Mediastinum; D023303:Oxazolidinones / Q000493:pharmacokinetics*; D010539:Permeability; D035422:Pleural Cavity / Q000378:metabolism*; D010996:Pleural Effusion / Q000378:metabolism
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid
keywords: Cardiovascular surgery; Linezolid; Mediastinitis; Penetration to mediastinum; Pharmacokinetics