title: Role of diffusion-weighted imaging in differentiating benign and malignant pediatric abdominal tumors.
abstract: BACKGROUND
  Solid malignant tumors are more highly cellular than benign lesions and hence have a restricted diffusion of water molecules.
  
  
  OBJECTIVE
  To evaluate whether diffusion-weighted MR imaging (DWI) can differentiate between benign and malignant pediatric abdominal tumors.
  
  
  METHODS
  We retrospectively analyzed DWI scans of 68 consecutive children with 39 benign and 34 malignant abdominal masses. To calculate the apparent diffusion coefficient (ADC) maps and ADC values, we used 1.5-T sequences at TR/TE/b-value of 5,250-7,500/54-64/b = 0, 500 and 3-T sequences at 3,500-4,000/66-73/b = 0, 500, 800. ADC values were compared between benign and malignant and between data derived at 1.5 tesla (T) and at 3 tesla magnetic field strength, using the Mann-Whitney-Wilcoxon test, ANOVA and a receiver operating curve (ROC) analysis.
  
  
  RESULTS
  There was no significant difference in ADC values obtained at 1.5 T and 3 T (P = 0.962). Mean ADC values (× 10(-3) mm(2)/s) were 1.07 for solid malignant tumors, 1.6 for solid benign tumors, 2.9 for necrotic portions of malignant tumors and 3.1 for cystic benign lesions. The differences between malignant and benign solid tumors were statistically significant (P = 0.000025). ROC analysis revealed an optimal cut-off ADC value for differentiating malignant and benign solid tumors as 1.29 with excellent inter-observer reliability (alpha score 0.88).
  
  
  CONCLUSIONS
  DWI scans and ADC values can contribute to distinguishing between benign and malignant pediatric abdominal tumors.
authors.affiliation: Department of Radiology, Stanford University, Stanford, CA, USA.
authors.forename: Rakhee S
authors.initials: RS
authors.lastname: Gawande
authors.forename: Gabriel
authors.initials: G
authors.lastname: Gonzalez
authors.forename: Solomon
authors.initials: S
authors.lastname: Messing
authors.forename: Aman
authors.initials: A
authors.lastname: Khurana
authors.forename: Heike E
authors.initials: HE
authors.lastname: Daldrup-Link
mesh_terms: D000008:Abdominal Neoplasms / Q000145:classification* / Q000473:pathology*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult