title: Hexachlorocyclohexanes (HCHs) in placenta and umbilical cord blood and dietary intake for women in Beijing, China.
abstract: Placenta and umbilical cord blood are important media for investigating maternal-fetal exposure to environmental pollutants. Historically hexachlorocyclohexanes (HCHs) were once widely-used in China. In this study, residues of HCHs were measured in placenta and umbilical cord blood samples for 40 women from Beijing. The measured median values of HCHs were 62.0 and 68.8 ng/g fat in placenta and umbilical cord blood, respectively. Concentrations of HCHs in placenta and umbilical cord blood of urban cohort were higher than those of rural group due to enhanced consumption of fish, meat, and milk. Residues of HCHs in placenta were significantly correlated with total food consumption, dietary intake, and maternal age, and could be predicted using the parameters dependent upon ingestion of meat and milk. The transplacental exposure of fetuses to HCHs was revealed by a close association between the residual levels in the paired placenta and the paired umbilical cord blood samples.
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, PR China.
authors.forename: Yanxin
authors.initials: Y
authors.lastname: Yu
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Xilong
authors.initials: X
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Wentao
authors.initials: W
authors.lastname: Wang
authors.forename: Guofeng
authors.initials: G
authors.lastname: Shen
authors.forename: Huizhong
authors.initials: H
authors.lastname: Shen
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Minghong
authors.initials: M
authors.lastname: Wong
authors.forename: Wenxin
authors.initials: W
authors.lastname: Liu
authors.forename: Shu
authors.initials: S
authors.lastname: Tao
mesh_terms: D000328:Adult; D002681:China; D004032:Diet / Q000706:statistics & numerical data*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D001556:Hexachlorocyclohexane / Q000097:blood / Q000378:metabolism*; D006801:Humans; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D004785:Environmental Pollutants; D001556:Hexachlorocyclohexane