title: Discrepant ratios of arterial versus venous thrombosis in hemophilia A as compared with hemophilia B.
abstract: The occurrence of thrombosis in patients with congenital bleeding disorders represents an exceptional event. Hemophilia A and hemophilia B patients have been showed to present both arterial and venous thrombosis (85 cases of arterial thrombosis and 34 cases of venous thrombosis). The great majority of arterial thrombosis are myocardial infarction or other acute coronary syndromes, whereas the majority of venous thrombosis are deep vein thrombosis and/or pulmonary embolisms. However there are discrepancies in the proportion of arterial and venous thrombosis seen in hemophilia A versus hemophilia B. The ratio of arterial versus venous thrombosis in hemophilia A is 3.72 whereas that for hemophilia B is 1.12. This indicates that arterial thrombosis is more frequent in hemophilia A as compared to hemophilia B and the opposite is true for venous thrombosis. The potential significance of this discrepancy is discussed.
authors.affiliation: Department of Medical and Surgical Sciences, Padua University, Via Ospedale, 105, 35128, Padua, Italy, antonio.girolami@unipd.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Girolami
authors.forename: Irene
authors.initials: I
authors.lastname: Bertozzi
authors.forename: Giulia Berti
authors.initials: GB
authors.lastname: de Marinis
authors.forename: Valentina
authors.initials: V
authors.lastname: Tasinato
authors.forename: Luisa
authors.initials: L
authors.lastname: Sambado
mesh_terms: D054058:Acute Coronary Syndrome / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006467:Hemophilia A / Q000150:complications / Q000453:epidemiology; D002836:Hemophilia B / Q000150:complications / Q000453:epidemiology; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000453:epidemiology / Q000209:etiology; D011655:Pulmonary Embolism / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology