title: Pallidal stimulation in children: comparison between cerebral palsy and DYT1 dystonia.
abstract: The authors compared the outcomes of 17 children aged 7 to 15 years with DYT1 dystonia or cerebral palsy following deep brain stimulation. While patients with cerebral palsy presented with significantly greater motor disability than the DYT1 cohort at baseline, both groups demonstrated improvement at 1 year (cerebral palsy = 24%; DYT1 = 6%). The group as a whole demonstrated significant improvement on the Barry-Albright Dystonia Scale across time. Gains in motor function were apparent in both axial and appendicular distributions involving both upper and lower extremities. Gains achieved by 6 months were sustained in the cerebral palsy group, whereas the DYT1 group demonstrated continued improvement with ongoing pallidal stimulation beyond 18 months. Young patients with dystonia due to cerebral palsy responded comparably to patients with DYT1 dystonia. The severity of motor impairment in patients with cerebral palsy at baseline and follow-up raises the issue of even earlier intervention with neuromodulation in this population to limit long-term motor impairments due to dystonia.
authors.affiliation: Department of Neurology, Cook Children's Medical Center, Fort Worth, TX 76104, USA. Warren.Marks@cookchildrens.org
authors.forename: Warren
authors.initials: W
authors.lastname: Marks
authors.forename: Laurie
authors.initials: L
authors.lastname: Bailey
authors.forename: Maryann
authors.initials: M
authors.lastname: Reed
authors.forename: Angela
authors.initials: A
authors.lastname: Pomykal
authors.forename: Mary
authors.initials: M
authors.lastname: Mercer
authors.forename: David
authors.initials: D
authors.lastname: Macomber
authors.forename: Fernando
authors.initials: F
authors.lastname: Acosta
authors.forename: John
authors.initials: J
authors.lastname: Honeycutt
mesh_terms: D000293:Adolescent; D002547:Cerebral Palsy / Q000628:therapy*; D002648:Child; D046690:Deep Brain Stimulation / Q000379:methods*; D004185:Disability Evaluation; D004422:Dystonia Musculorum Deformans / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009068:Movement / Q000502:physiology; D016896:Treatment Outcome
keywords: DYT1; cerebral palsy; deep brain stimulation; dystonia; globus pallidus