title: Neuroimaging markers for the prediction of treatment response to Methylphenidate in ADHD.
abstract: BACKGROUND
  Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent mental disorders of childhood, which often continues into adulthood. Methylphenidate is one the most commonly used medication to treat ADHD, however up to 30% of patients do not respond to it.
  
  
  OBJECTIVE
  This paper aims to review studies, which employed neuroimaging to predict treatment response to Methylphenidate in ADHD.
  
  
  METHODS
  Systematic literature searches were performed using several databases. Selected articles had to describe an original study that identified neuroimaging markers for the prediction of treatment response to Methylphenidate in ADHD.
  
  
  RESULTS
  Eighty-three articles were found, of which twelve were selected for the present review. Several neuroimaging markers to predict response to MPH were suggested including DAT status, size of medial prefrontal cortex and corpus callosum.
  
  
  CONCLUSIONS
  Some promising findings have been identified and they should motivate additional work to establish more reliable neuroimaging markers of treatment response to MPH in ADHD.
authors.affiliation: Department of Psychiatry, Trinity College Dublin, Ireland; Department of Psychiatry and Developmental Psychology, University of Nagoya, Japan; Department of Psychiatry, Children's University Hospital, Dublin, Ireland. Electronic address: N_Skokauskas@yahoo.com.
authors.forename: Norbert
authors.initials: N
authors.lastname: Skokauskas
authors.forename: Kaneko
authors.initials: K
authors.lastname: Hitoshi
authors.forename: Honjo
authors.initials: H
authors.lastname: Shuji
authors.forename: Thomas
authors.initials: T
authors.lastname: Frodl
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D016208:Databases, Factual / Q000706:statistics & numerical data; D006801:Humans; D008774:Methylphenidate / Q000627:therapeutic use*; D059906:Neuroimaging; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate
keywords: ADHD; Methylphenidate; Neuroimaging and treatment response