title: miR-155* mediates suppressive effect of PTEN 3'-untranslated region on AP-1/NF-κB pathway in HTR-8/SVneo cells.
abstract: Among miRNAs, miR-155 is a known regulator of immune system. Accumulating studies have revealed the connections between miR-155 and activator protein 1 (AP-1)/nuclear factor (NF)-κB. However, miR-155*, a miR-155 paralog, has so far been less studied. Here we demonstrated that miR-155*, induced by lipopolysaccharide (LPS) in an AP-1/NF-κB dependent manner, played a positive feedback role in AP-1/NF-κB pathway via targeting interleukin-1 receptor-associated kinase M (IRAKM) and NF-κB inhibitor interacting Ras-like 1 (NKIRAS1) in trophoblasts. Our study further proved that miR-155*-targeted PTEN 3'-untranslated region (3'UTR) increased IRAKM and NKIRAS1 expression by competing for miR-155* binding, thereby suppressing AP-1/NF-κB activation induced by LPS.
authors.affiliation: Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing 210029, China.
authors.forename: P
authors.initials: P
authors.lastname: Xue
authors.forename: M
authors.initials: M
authors.lastname: Zheng
authors.forename: Z
authors.initials: Z
authors.lastname: Diao
authors.forename: L
authors.initials: L
authors.lastname: Shen
authors.forename: M
authors.initials: M
authors.lastname: Liu
authors.forename: P
authors.initials: P
authors.lastname: Gong
authors.forename: H
authors.initials: H
authors.lastname: Sun
authors.forename: Y
authors.initials: Y
authors.lastname: Hu
mesh_terms: D020413:3' Untranslated Regions / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism; D002460:Cell Line; D005260:Female; D006801:Humans; D053592:Interleukin-1 Receptor-Associated Kinases / Q000096:biosynthesis / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D035683:MicroRNAs / Q000502:physiology*; D016328:NF-kappa B / Q000378:metabolism*; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000494:pharmacology*; D018808:Transcription Factor AP-1 / Q000378:metabolism*; D014327:Trophoblasts / Q000502:physiology
chemical_list: D020413:3' Untranslated Regions; D002352:Carrier Proteins; D008070:Lipopolysaccharides; C524942:MIRN155 microRNA, human; D035683:MicroRNAs; D016328:NF-kappa B; C576702:NKIRAS1 protein, human; D018808:Transcription Factor AP-1; C507771:IRAK3 protein, human; D053592:Interleukin-1 Receptor-Associated Kinases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human