title: Predicting sputum eosinophilia in exacerbations of COPD using exhaled nitric oxide.
abstract: Fractional exhaled nitric oxide (FENO) may be a pulmonary biomarker in chronic obstructive pulmonary disease (COPD). In this prospective study, the relationship between FENO and airway inflammation was assessed in COPD exacerbations. FENO and lung function were measured, and sputum was collected from 49 ex-smoking COPD patients, first at the time of hospital admission and again at discharge following treatment. There was a significant positive correlation between the percentage of sputum eosinophils and FENO concentrations, both at exacerbation (r = 0.593, p < 0.001) and discharge (r = 0.337, p = 0.044). The increase in forced expiratory volume in one second (FEV(1)) after treatment was greater in patients with sputum eosinophilia (ΔFEV(1) 0.35 ± 0.12 vs. 0.13 ± 0.04 L, p = 0.046), and FENO was a strong predictor of sputum eosinophilia (area under the receiver operating characteristic curve, 0.89). The optimum cut point was 19 parts per billion (sensitivity: 90 %; specificity: 74 %). Our data suggest that FENO is a good surrogate marker of eosinophilic inflammation in COPD patients with exacerbations.
authors.affiliation: Department of Pulmonology, National Koranyi Institute of TB and Pulmonology, Piheno ut 1, 1121, Budapest, Hungary.
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Soter
authors.forename: Imre
authors.initials: I
authors.lastname: Barta
authors.forename: Balazs
authors.initials: B
authors.lastname: Antus
mesh_terms: D000368:Aged; D015415:Biomarkers; D004802:Eosinophilia / Q000503:physiopathology*; D045853:Exhalation; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007958:Leukocyte Count; D008168:Lung / Q000503:physiopathology*; D008297:Male; D009569:Nitric Oxide / Q000032:analysis*; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012907:Smoking / Q000276:immunology; D016540:Smoking Cessation; D013183:Sputum / Q000166:cytology*
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide