title: Lipid peroxidation markers in adult attention deficit hyperactivity disorder: new findings for oxidative stress.
abstract: Malondialdehyde (MDA) is a reliable marker of lipid peroxidation where paraoxonase and arylesterase are two enzymes against it. Although increased MDA has been previously shown in adults with attention deficit/hyperactivity disorder (A-ADHD), levels of paraoxonase and arylesterase enzymes have not been studied yet. We aimed to determine the status of both MDA level and paraoxonase and arylesterase enzyme activities in A-ADHD patients. A total of 35 adults with ADHD diagnosis according to Diagnostic and Statistical Manual of Mental Disorders fourth edition (DSM-IV) criteria and 29 healthy volunteers were included in the study. Serum MDA, paraoxonase and arylesterase levels of the participants were measured. The disease severity of the patients was determined by using Turgay's Adult Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder (ADD/ADHD) DSM IV Based Diagnostic Screening and Rating Scale. The serum MDA level of patients was significantly higher than that of healthy control subjects, whereas their paraoxonase and arylesterase levels were significantly lower. There was no correlation between the levels of biochemical parameters (MDA, paraoxonase and arylesterase) and the disease severity. Sub-types of A-ADHD were similar in terms of these biochemical parameters. Increased lipid peroxidation, a part of oxidative stress, in adults with ADHD appears to be unbuffered by antioxidant enzymes, namely paraoxonase and arylesterase.
authors.affiliation: Dicle University, Faculty of Medicine, Psychiatry Department, Diyarbakir, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Bulut
authors.forename: Salih
authors.initials: S
authors.lastname: Selek
authors.forename: Yasin
authors.initials: Y
authors.lastname: Bez
authors.forename: Mehmet
authors.initials: M
authors.lastname: Cemal Kaya
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gunes
authors.forename: Fatih
authors.initials: F
authors.lastname: Karababa
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.forename: Haluk Asuman
authors.initials: HA
authors.lastname: Savas
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood / Q000503:physiopathology*; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D010554:Personality Disorders / Q000150:complications; D011569:Psychiatric Status Rating Scales; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D008315:Malondialdehyde; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase
keywords: Adult ADHD; Arylesterase; Lipid peroxidation; Malondialdehyde; Oxidative stress; Paraoxonase