title: Two seasons' experience with pandemic A H1N1 influenza infection in neonates.
abstract: There are only a few reports on influenza A H1N1 infection in neonates. In this paper, we present our additional experience on the clinical characteristics, epidemiology and treatment of influenza A H1N1 (2009) infection in 10 newborn infants (aged 9-24 days). Influenza A H1N1 infection was confirmed by real-time reverse transcription-polymerase chain reaction of the nasopharyngeal swab specimens. The majority of neonates presented with fever, respiratory symptoms and lethargy. The respiratory illness ranged from mild symptoms to severe pneumonia requiring mechanical ventilation. Antiviral treatment with oseltamivir was started in five patients (50%). One lethal outcome was observed, while nine patients (90%) had complete recovery. To our knowledge, this is the largest presented series of neonatal cases with different clinical symptoms. We discuss the necessity of initiation of oseltamivir in infants with different clinical features.
authors.affiliation: Mother and Child Health Care Institute "Dr Vukan Cupic", Vaccine and Sera "Torlak", Belgrade, Serbia. jelena@net2yu.net.
authors.forename: Jelena
authors.initials: J
authors.lastname: Martic
authors.forename: Natasa
authors.initials: N
authors.lastname: Savic
authors.forename: Borisav
authors.initials: B
authors.lastname: Jankovic
authors.forename: Jasminka
authors.initials: J
authors.lastname: Nedeljkovic
authors.forename: Zorika
authors.initials: Z
authors.lastname: Rakonjac
authors.forename: Katarina
authors.initials: K
authors.lastname: Pejic
authors.forename: Gordana
authors.initials: G
authors.lastname: Markovic-Sovtic
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology; D008297:Male; D058873:Pandemics; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012621:Seasons; D055771:Serbia / Q000453:epidemiology
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral