title: Keratocystic odontogenic tumor: a retrospective analysis of genetic, immunohistochemical and therapeutic features. Proposal of a multicenter clinical survey tool.
abstract: OBJECTIVE
  In 2005, the World Health Organization reclassified the parakeratinizing odontogenic keratocyst as a neoplasm. This article reviews the research leading to this reclassification, and validates a new survey tool that can be easily used to pool surgical and recurrence data from multiple offices.
  
  
  METHODS
  All odontogenic lesions accessioned in the Iowa Surgical Oral Pathology Laboratory between 1949 and 2010 were identified from the database. A survey tool to assess treatment and follow-up was created. A total of 46 surgeons agreed to participate.
  
  
  RESULTS
  A total of 70 keratocystic odontogenic tumors (KOTs) had documented recurrences at follow-up intervals ranging from 6 months to 5 years. Primary tumors that recurred ranged in size as measured by greatest radiographic diameter from 0.7 to 6 cm.
  
  
  CONCLUSIONS
  This survey tool is recommended as standard allowing treatment of cases by multiple practitioners to be compared retrospectively or prospectively.
authors.affiliation: University of Iowa, College of Dentistry, Iowa City, IA 52242-1001, USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Finkelstein
authors.forename: John W
authors.initials: JW
authors.lastname: Hellstein
authors.forename: Kimberly S
authors.initials: KS
authors.lastname: Lake
authors.forename: Steven D
authors.initials: SD
authors.lastname: Vincent
mesh_terms: D003625:Data Collection / Q000379:methods*; D005260:Female; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D007573:Jaw Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy; D008297:Male; D009364:Neoplasm Recurrence, Local; D009807:Odontogenic Cysts / Q000235:genetics / Q000473:pathology / Q000628:therapy; D012189:Retrospective Studies