title: Role of molecular analysis in the adjuvant treatment of gastrointestinal stromal tumours: it is time to define it.
abstract: Sendur et al pointed out the attention on the importance of mutational analysis for adjuvant treatment of gastrointestinal stromal tumor (GIST) in an article published in World Journal of Gastroenterology. In particular, they suggested that the optimal dose and duration of adjuvant therapy could be defined by the mutational status of the primary disease. This comment would underline the importance of centralised laboratories, given the increasingly important role of molecular analysis in the work-flow of all GIST, and the need of retrospective analyses for subgroups population stratified for the mutational status from the available studies in the adjuvant setting, in order to define the role of mutational analysis in choosing the optimal dose and duration of adjuvant therapy.
authors.forename: Margherita
authors.initials: M
authors.lastname: Nannini
authors.forename: Maria A
authors.initials: MA
authors.lastname: Pantaleo
authors.forename: Guido
authors.initials: G
authors.lastname: Biasco
mesh_terms: D017024:Chemotherapy, Adjuvant / Q000379:methods*; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D009154:Mutation
keywords: Adjuvant treatment; Gastrointestinal stromal tumours; Imatinib; KIT; Molecular analysis; Platelet-derived growth factor receptor alpha; Wild-type