title: Predicting risk severity and response of fetal neonatal alloimmune thrombocytopenia.
abstract: Fetal neonatal alloimmune thrombocytopenia (FNAIT) is a devastating bleeding disorder in the fetus or neonate caused by transplacental transport of maternal alloantibodies to paternal-derived antigen on fetal platelets. In Caucasians, up to 80% of FNAIT cases result from maternal immunization to human platelet antigen (HPA)-1a. New methods have developed facilitating detection of common and private antibodies against HPAs triggering FNAIT. Understanding the pathogenesis of FNAIT made it possible to develop a novel strategy to treat this disorder. To date, recombinant monoclonal antibodies directed against the β3 integrin and Fc receptors have been tested in a mouse model of FNAIT, and seem to be promising. Whether those novel treatments will eventually replace the conventional high dose immunoglobulin G in women with FNAIT is yet unknown.
authors.affiliation: Amalia Biron Research Institute of Thrombosis and Haemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel. ophiras@sheba.health.gov.il
authors.forename: Ophira
authors.initials: O
authors.lastname: Salomon
authors.forename: Nurit
authors.initials: N
authors.lastname: Rosenberg
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D016824:Antigens, Human Platelet / Q000235:genetics / Q000276:immunology; D005260:Female; D005315:Fetal Diseases / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D039661:Integrin beta3 / Q000276:immunology; D007518:Isoantibodies / Q000097:blood; D051379:Mice; D011181:Postnatal Care / Q000379:methods; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods; D011961:Receptors, Fc / Q000276:immunology; D018570:Risk Assessment / Q000379:methods; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000235:genetics / Q000276:immunology / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal; D016824:Antigens, Human Platelet; D039661:Integrin beta3; D007518:Isoantibodies; D011961:Receptors, Fc
keywords: fetal blood sampling; human platelet antibodies; human platelet antigen; intracranial haemorrhage; neonatal alloimmune thrombocytopenia