title: Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe.
abstract: We propose a microneedle coated with silver (Ag) to detect analytes at low concentrations positioned at a depth of more than 700 μm below the surface of a skin phantom with absorbers and scatterers for mimicking the intradermal surface-enhanced Raman scattering (SERS) measurements. The Ag layer in the Ag-coated microneedle-based probe is found to be the key to the effective detection of analytes buried inside the aforesaid phantom. Glucose concentrations ranging from 5 to 150 mM inside phantoms can be estimated with a root mean square error (RMSE) of 3.3 mM. This work shows the potential of using microneedles for simple in vivo intradermal SERS measurements of analytes with clinical relevance.
authors.affiliation: Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore.
authors.forename: Clement
authors.initials: C
authors.lastname: Yuen
authors.forename: Quan
authors.initials: Q
authors.lastname: Liu
mesh_terms: D005947:Glucose / Q000737:chemistry; D009339:Needles; D019047:Phantoms, Imaging; D012834:Silver; D012867:Skin / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000295:instrumentation*
chemical_list: D012834:Silver; D005947:Glucose
keywords: Raman; intradermal glucose measurement; partial least squares (PLS); surface enhanced Raman scattering (SERS)