title: Chelation of chromium(VI) by combining deferasirox and deferiprone in rats.
abstract: The present research is aimed to characterize the potential efficiency of two chelators after chromium(VI) administration for 60 days following two doses of 15 and 30 mg/kg chromium(VI) per body weight daily to male rats. However, the hypothesis that the two chelators might be more efficient as combined therapy than as single therapy in removing chromium(VI) from rat organs was considered. In this way, two known chelators deferasirox and deferiprone were chosen and given orally as a single or combined therapy for a period of 1 week. Chromium(VI) and iron concentrations in tissues were determined by flame atomic absorption spectroscopy. The combined chelation therapy results show that deferasirox and deferiprone are able to remove chromium(VI) ions from various tissues while iron concentration returned to normal levels and symptoms also decreased.
authors.affiliation: Chemistry Department, Shahid Bahonar University of Kerman, 22 Bahman Blvd, PO BOX 76961, Kerman, Iran. mzh_iranmanesh@yahoo.com
authors.forename: Marzieh
authors.initials: M
authors.lastname: Iranmanesh
authors.forename: S Jamil A
authors.initials: SJ
authors.lastname: Fatemi
authors.forename: Roza
authors.initials: R
authors.lastname: Ebrahimpour
authors.forename: Faezeh
authors.initials: F
authors.lastname: Dahooee Balooch
mesh_terms: D000818:Animals; D001565:Benzoates / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects; D002614:Chelating Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015913:Chelation Therapy; D002857:Chromium / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000633:toxicity; D000077588:Deferasirox; D000077543:Deferiprone; D008297:Male; D015394:Molecular Structure; D011728:Pyridones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution / Q000187:drug effects; D014230:Triazoles / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D001565:Benzoates; D002614:Chelating Agents; D011728:Pyridones; D014230:Triazoles; D002857:Chromium; D000077543:Deferiprone; D000077588:Deferasirox