title: Clinical significance of serum autoantibodies in idiopathic interstitial pneumonia.
abstract: Although autoantibodies are routinely screened in patients with idiopathic interstitial pneumonia, there are no reliable data on their clinical usefulness. The aim of this study was to investigate the prognostic value of autoantibodies for predicting the development of new connective tissue disease in these patients and also mortality. We conducted retrospective analysis of the baseline, and follow-up data for 688 patients with idiopathic interstitial pneumonia (526 with idiopathic pulmonary fibrosis, 85 with nonspecific interstitial pneumonia, and 77 with cryptogenic organizing pneumonia) at one single tertiary referral center. The median follow-up period was 33.6 months. Antinuclear antibody was positive in 34.5% of all subjects, rheumatoid factor in 13.2%, and other specific autoantibodies were positive between 0.7%-6.8% of the cases. No significant difference in patient survival was found between the autoantibody-positive and -negative groups. However, the presence of autoantibodies, especially antinuclear antibody with a titer higher than 1:320, was a significant predictor for the future development of new connective tissue diseases (relative risk, 6.4), although the incidence was low (3.8% of all subjects during follow-up). In conclusion, autoantibodies are significant predictors for new connective tissue disease development, although they have no prognostic value.
authors.affiliation: Department of Pulmonary and Critical Care Medicine, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Bo Hyoung
authors.initials: BH
authors.lastname: Kang
authors.forename: Jin Kyeong
authors.initials: JK
authors.lastname: Park
authors.forename: Jae Hyung
authors.initials: JH
authors.lastname: Roh
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Song
authors.forename: Chang Keun
authors.initials: CK
authors.lastname: Lee
authors.forename: Miyoung
authors.initials: M
authors.lastname: Kim
authors.forename: Se Jin
authors.initials: SJ
authors.lastname: Jang
authors.forename: Thomas V
authors.initials: TV
authors.lastname: Colby
authors.forename: Dong Soon
authors.initials: DS
authors.lastname: Kim
mesh_terms: D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D015331:Cohort Studies; D003240:Connective Tissue Diseases / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012217:Rheumatoid Factor / Q000097:blood; D012307:Risk Factors; D062606:Tertiary Care Centers; D014057:Tomography, X-Ray Computed
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D012217:Rheumatoid Factor
keywords: Antinuclear Antibody; Autoantibody; Connective Tissue Disease; Cryptogenic Organizing Pneumonia; Idiopathic Interstitial Pneumonias; Idiopathic Pulmonary Fibrosis; Incidence; Nonspecific Interstitial Pneumonia; Predictive Factor; Rheumatoid Factor