title: Neovascular glaucoma induced by peripheral retinal ischemia in neurofibromatosis type 1: management and imaging features.
abstract: OBJECTIVE
  To report the case of a young patient affected by neurofibromatosis 1 (NF-1) with peripheral retinal ischemia-induced neovascular glaucoma and the peculiar spectral-domain optical coherence tomography (SD-OCT) features.
  
  
  METHODS
  A 13-year-old boy affected by NF-1, as diagnosed according to established criteria, was referred with a diagnosis of hypertensive uveitis in his left eye. He underwent a complete ophthalmic examination and comprehensive blood work with viral and immunological tests. The case was documented with fluorescein angiography (FA) and SD-OCT. When the intraocular pressure (IOP) of the left eye decreased and the cornea cleared, FA revealed retinal ischemia and leakage from pathologic retinal vessels. SD-OCT revealed foveal hypoplasia secondary to the complete absence of the retinal nerve fiber layer.
  
  
  RESULTS
  Peripheral retinal ischemia-induced neovascular glaucoma was diagnosed. The patient underwent Ahmed valve implantation to control his IOP, and subsequent retinal photocoagulation by argon laser and intravitreal bevacizumab injection were performed to control neovascularization.
  
  
  CONCLUSIONS
  Retinal ischemia in NF-1 might lead to neovascular glaucoma: lowering of the IOP with surgical implantation of an Ahmed valve, regression of neovascularization by argon laser panretinal photocoagulation and intravitreal injection of bevacizumab can be a helpful way to control such a complication.
authors.affiliation: University Eye Clinic, San Giuseppe Hospital, Milan, Messina, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pichi
authors.forename: Mariachiara
authors.initials: M
authors.lastname: Morara
authors.forename: Andrea
authors.initials: A
authors.lastname: Lembo
authors.forename: Antonio P
authors.initials: AP
authors.lastname: Ciardella
authors.forename: Alessandro
authors.initials: A
authors.lastname: Meduri
authors.forename: Paolo
authors.initials: P
authors.lastname: Nucci
keywords: Neovascular glaucoma; Neurofibromatosis; Retinal ischemia