title: Comment on "Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice".
abstract: Giovanoli et al. (Reports, 1 March 2013, p. 1095) applied an immune challenge to pregnant females, and therefore to all offspring, and subsequently applied stress to offspring on a per cage basis. The data, however, were analyzed as a completely randomized design, which is inappropriate given these restrictions on randomization. This will increase both false positives and false negatives.
authors.affiliation: In Silico Lead Discovery, Novartis Institutes for Biomedical Research, Basel, Switzerland. stan.lazic@cantab.net
authors.forename: Stanley E
authors.initials: SE
authors.lastname: Lazic
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D001523:Mental Disorders / Q000276:immunology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology*; D011627:Puberty / Q000276:immunology*; D013312:Stress, Physiological / Q000276:immunology*