title: The innate immune response during liver inflammation and metabolic disease.
abstract: The role of the inflammatory response is to combat tissue injury and infection. Innate immune cells recognize cell damage or pathogen invasion with intracellular or surface-expressed pattern recognition receptors (PRRs). Activated PRRs subsequently initiate signaling cascades that trigger the release of factors promoting the inflammatory response. Because the liver is a site where foreign antigens from the gastrointestinal tract encounter the immune system, it is particularly enriched with innate immune cells. These cells can modify and disrupt critical processes implicated in metabolic disease. As such, metabolic stress initiates a feedforward cycle of inflammatory responses, resulting in a state of unresolved chronic inflammation in the liver. Accordingly, the crosstalk between these innate immune cells and the resident parenchymal cells plays an important role in the development of acute and chronic liver disease.
authors.affiliation: Department of Internal Medicine III, University Hospital, RWTH-Aachen, Germany. Electronic address: vbieghs@ukaachen.de.
authors.forename: Veerle
authors.initials: V
authors.lastname: Bieghs
authors.forename: Christian
authors.initials: C
authors.lastname: Trautwein
mesh_terms: D000818:Animals; D006505:Hepatitis / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D058847:Inflammasomes / Q000276:immunology* / Q000378:metabolism; D024821:Metabolic Syndrome / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology* / Q000378:metabolism
chemical_list: D058847:Inflammasomes; D051193:Toll-Like Receptors
keywords: IL-1; TNF; Toll-like receptors; inflammasome; innate Immunity; liver Inflammation