title: Multiple functions of the RNA-binding protein HuR in cancer progression, treatment responses and prognosis.
abstract: The human embryonic lethal abnormal vision-like protein, HuR, is a member of the Hu family of RNA-binding proteins. Over the past decade, this ubiquitously expressed protein has been extensively investigated in cancer research because it is involved in the regulation of mRNA stability and translation in many cell types. HuR activity and function is associated with its subcellular distribution, transcriptional regulation, translational and post-translational modifications. HuR regulation of target mRNAs is based on the interaction between the three specific domains of HuR protein and one or several U- or AU-rich elements (AREs) in the untranslated region of target mRNAs. A number of cancer-related transcripts containing AREs, including mRNAs for proto-oncogenes, cytokines, growth factors, and invasion factors, have been characterized as HuR targets. It has been proposed that HuR has a central tumorigenic activity by enabling multiple cancer phenotypes. In this review, we comprehensively survey the existing evidence with regard to the diverse functions of HuR in caner development and progression. The current data also suggest that HuR might be a novel and promising therapeutic target and a marker for treatment response and prognostic evaluation.
authors.affiliation: Department of Oncology, General Hospital, Jinan Command of the People's Liberation Army, Jinan 250031, China. ggjun2005@126.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Huili
authors.initials: H
authors.lastname: Chu
authors.forename: Yaping
authors.initials: Y
authors.lastname: Guan
authors.forename: Jingwang
authors.initials: J
authors.lastname: Bi
authors.forename: Baocheng
authors.initials: B
authors.lastname: Wang
mesh_terms: D000818:Animals; D000067780:ELAV-Like Protein 1 / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D011379:Prognosis; D021381:Protein Transport; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D000067780:ELAV-Like Protein 1; D012333:RNA, Messenger