title: Asymmetric synthesis of tetrahydro-β-carbolines via chiral phosphoric acid catalyzed transfer hydrogenation reaction.
abstract: Chiral phosphoric acid catalyzed enantioselective transfer hydrogenation of hydroxylactams has been realized to provide enantioenriched tetrahydro-β-carbolines in dioxane at room temperature (up to 94% yield, 90% ee).
authors.affiliation: State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Yin
authors.forename: Shou-Guo
authors.initials: SG
authors.lastname: Wang
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You
mesh_terms: D002243:Carbolines / Q000138:chemical synthesis*; D002384:Catalysis; D006865:Hydrogenation; D007769:Lactams / Q000737:chemistry*; D015394:Molecular Structure; D010756:Phosphoric Acids / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002243:Carbolines; D007769:Lactams; D010756:Phosphoric Acids