title: Angiotensin III: a physiological relevant peptide of the renin angiotensin system.
abstract: The renin angiotensin system (RAS) is a peptide hormone system that plays an important role in the pathophysiology of various diseases, including congestive heart failure, hypertension, myocardial infarction, and diabetic nephropathy. This has led researchers to focus extensively on this system, leading to the discovery of various peptides, peptidases, receptors and signal transduction mechanisms intrinsic to the RAS. Angiotensinogen (AGT), angiotensin (Ang) II, Ang III, Ang IV, and Ang-(1-7) are the main biologically active peptides of RAS. However, most of the available studies have focused on Ang II as the likely key peptide from the RAS that directly and indirectly regulates physiological functions leading to pathological conditions. However, data from recent studies suggest that Ang III may produce physiologically relevant effects that are similar to those produced by Ang II. Hence, this review focuses on Ang III and the myriad of physiological effects that it produces in the body.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, 3200 South University Drive, Fort Lauderdale, FL 33328, USA.
authors.forename: Vudhya G
authors.initials: VG
authors.lastname: Yugandhar
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Clark
mesh_terms: D000805:Angiotensin III / Q000502:physiology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D002318:Cardiovascular Diseases / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000378:metabolism; D006801:Humans; D051381:Rats; D012084:Renin-Angiotensin System / Q000502:physiology*; D015398:Signal Transduction; D012964:Sodium / Q000502:physiology; D013894:Thirst / Q000502:physiology; D014667:Vasopressins / Q000378:metabolism
chemical_list: D014667:Vasopressins; D000805:Angiotensin III; D009320:Atrial Natriuretic Factor; D012964:Sodium
keywords: Aminopeptidase A; Angiotensin; Blood pressure; Cardiovascular; Renin angiotensin system; Sodium appetite; Vasopressin