title: Route to destruction: autophagosomes SNARE lysosomes.
abstract: Autophagy allows cells to encapsulate parts of their cytosol into unique double-membrane structures. These autophagosomes mature to fuse with lysosomes and deliver the enclosed contents for degradation. Three recent papers, including one by Takáts et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201211160), have taken different routes to discover a role for Syntaxin 17 in the maturation of autophagosomes.
authors.affiliation: Department of Neuroscience and 2 Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Helmut
authors.initials: H
authors.lastname: Krämer
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology*; D008247:Lysosomes / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D010588:Phagosomes / Q000502:physiology*; D050765:Qa-SNARE Proteins / Q000378:metabolism*; D050683:R-SNARE Proteins / Q000378:metabolism*; D050600:SNARE Proteins / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D050765:Qa-SNARE Proteins; D050683:R-SNARE Proteins; D050600:SNARE Proteins; C582206:Snap29 protein, Drosophila; C582207:VAMP7 protein, Drosophila