title: No association between the intake of marine n-3 PUFA during the second trimester of pregnancy and factors associated with cardiometabolic risk in the 20-year-old offspring.
abstract: The intake of marine n-3 PUFA has been shown to decrease the risk of CVD in a number of studies. Since the development of CVD is often a lifelong process, marine n-3 PUFA intake early in life may also affect the development of later CVD. The aim of the present study was to investigate the association between maternal intake of marine n-3 PUFA during the second trimester of pregnancy and factors associated with cardiometabolic risk in the 20-year-old offspring. The study was based on the follow-up of the offspring of a Danish pregnancy cohort who participated in a study conducted from 1988 to 1989. A total of 965 pregnant women were originally included in the cohort and detailed information about the intake of marine n-3 PUFA during the second trimester was collected. In 2008-9, the offspring were invited to participate in a clinical examination including anthropometric, blood pressure (BP) and short-term heart rate variability measurements. Also, a fasting venous blood sample was drawn from them. Multiple linear regression modelling, using the lowest quintile of marine n-3 PUFA intake as the reference, was used to estimate the association with all outcomes. A total of 443 offspring participated in the clinical examination. No association between the intake of marine n-3 PUFA during the second trimester of pregnancy and offspring adiposity, glucose metabolism, BP or lipid profile was found. In conclusion, no association between the intake of marine n-3 PUFA during the second trimester of pregnancy and the factors associated with cardiometabolic risk in the 20-year-old offspring could be detected.
authors.affiliation: Section for Epidemiology, Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000 Aarhus C, Denmark.
authors.forename: Dorte
authors.initials: D
authors.lastname: Rytter
authors.forename: Bodil H
authors.initials: BH
authors.lastname: Bech
authors.forename: Thorhallur
authors.initials: T
authors.lastname: Halldorsson
authors.forename: Jeppe H
authors.initials: JH
authors.lastname: Christensen
authors.forename: Erik B
authors.initials: EB
authors.lastname: Schmidt
authors.forename: Inge
authors.initials: I
authors.lastname: Danielsen
authors.forename: Tine B
authors.initials: TB
authors.lastname: Henriksen
authors.forename: Sjurdur F
authors.initials: SF
authors.lastname: Olsen
mesh_terms: D000328:Adult; D059001:Aquatic Organisms / Q000378:metabolism*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D019587:Dietary Supplements; D050171:Dyslipidemias / Q000453:epidemiology / Q000517:prevention & control; D015525:Fatty Acids, Omega-3 / Q000378:metabolism / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D044882:Glucose Metabolism Disorders / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000517:prevention & control; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D050177:Overweight / Q000453:epidemiology / Q000517:prevention & control; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D015995:Prevalence; D012307:Risk Factors; D017747:Seafood / Q000032:analysis*; D055815:Young Adult
chemical_list: D015525:Fatty Acids, Omega-3