title: A bioassay-driven discovery of an unexpected selenophene and its cytotoxicity.
abstract: During the reaction of methyl 3β-acetoxy-glycyrrhetinate (1) with SeO2 significant amounts of a cytotoxic hitherto unprecedented triterpenoic selenophene 3 are formed. This compound stops cell proliferation and acts by apoptosis.
authors.affiliation: Martin-Luther-Universität Halle-Wittenberg, Organische Chemie, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany. rene.csuk@chemie.uni-halle.de
authors.forename: René
authors.initials: R
authors.lastname: Csuk
authors.forename: Bianka
authors.initials: B
authors.lastname: Siewert
authors.forename: Jana
authors.initials: J
authors.lastname: Wiemann
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001681:Biological Assay; D049109:Cell Proliferation / Q000187:drug effects; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D008856:Microscopy, Fluorescence; D008958:Models, Molecular; D041681:NIH 3T3 Cells; D016566:Organoselenium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D010084:Oxidation-Reduction
chemical_list: D000970:Antineoplastic Agents; D016566:Organoselenium Compounds; D006034:Glycyrrhetinic Acid