title: Clinical Significance of CENP-H Expression in Uterine Cervical Cancer.
abstract: OBJECTIVE
  This work aims to investigate the expression pattern and clinicopathologic significance of centromere protein H (CENP-H) in uterine cervical cancer (UCC).
  
  
  METHODS
  The level of CENP-H expression in the paraffin sections of 62 UCC cases was determined by the SP immunohistochemical method, with complete clinicopathologic data in all cases. Statistical analysis was conducted to evaluate the prognostic and diagnostic significance of CENP-H using SPSS13.0 software package.
  
  
  RESULTS
  Immunohistochemical assay showed strong CENP-H expression in 61.29% (38/62) of the paraffin-embedded cervical cancer tissues. Statistical analysis revealed a strong correlation between the CENP-H expression and the clinical classification (P=0.038) of the cervical carcinoma. The expression increased with rise of the stages. The analysis of Cox proportional hazards regression model suggested that CENP-H expression (P=0.002) and tumor stage (P=0.001) were independent prognostic markers for the survival of UCC patients. The survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H (P=0.001).
  
  
  CONCLUSIONS
  CENP-H is likely to be a valuable marker for carcinogenesis and progression of UCC. It might be used as the important diagnostic and prognostic marker for cervical carcinoma patients, especially for those at early stage.
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.
authors.forename: Mei-Ying
authors.initials: MY
authors.lastname: Weng
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Shun-Jia
authors.initials: SJ
authors.lastname: Hong
authors.forename: Shu-Ying
authors.initials: SY
authors.lastname: Feng
keywords: CENP-H; immunohistochemistry; prognosis; tumor staging; uterine cervical cancer; uterine cervix