title: Bifunctional titanocene catalysis in multicomponent couplings: a convergent assembly of β-alkynyl ketones.
abstract: Herein is described a titanium-catalyzed three-component coupling to assemble β-alkynyl ketones in a single operation. Treatment of an aryl aldehyde with an acetylide and silyl enol ether in the presence of a bifunctional titanocene catalyst enables the highly convergent assembly of β-alkynyl ketones in good to excellent yields.
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Campos
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Gianino
authors.forename: Brandon L
authors.initials: BL
authors.lastname: Ashfeld