title: High tracking of apolipoprotein B levels from the prepubertal age to adolescence in Spanish children.
abstract: OBJECTIVE
  To assess tracking of lipid and apolipoproteins from the prepubertal age (baseline, 6-8 years old) to adolescence (follow-up, 13-16 years old) in Spanish children.
  
  
  METHODS
  The sample population included 385 healthy children (179 boys and 206 girls). Tracking was estimated by correlations between baseline and follow-up levels, multiple regression models in which the follow-up lipid was the dependent variable and analysing the percentage of individuals who remained in the same lipid levels status from prepubertal age to adolescence.
  
  
  RESULTS
  Correlations between baseline and follow-up levels for low density lipoprotein (LDL)-cholesterol and apolipoprotein B (apo B) were stronger in boys and for high density lipoprotein-cholesterol and apo A-I stronger in girls. Regression analyses showed that, after adjusting by body mass index (BMI), baseline LDL-cholesterol and apo B levels explain 23% and 39% of the variation of follow-up LDL-cholesterol and apo B levels, respectively, in boys and 13% and 22%, respectively, in girls. The strength of tracking for LDL-cholesterol and apo B was 79% and 89%, respectively, in boys and 72% and 82%, respectively, in girls.
  
  
  CONCLUSIONS
  Apolipoprotein B showed the strongest tracking in both sexes, stronger than for LDL-cholesterol, which supports the importance of determining apo B levels as a marker of dyslipidaemia in children.
authors.affiliation: Lipid Research Laboratory, IIS-Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: del Villar-Rubín
authors.forename: R
authors.initials: R
authors.lastname: Escorihuela
authors.forename: H
authors.initials: H
authors.lastname: Ortega-Senovilla
authors.forename: M
authors.initials: M
authors.lastname: de Oya
authors.forename: C
authors.initials: C
authors.lastname: Garcés
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000886:Anthropometry; D001055:Apolipoproteins B / Q000032:analysis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000032:analysis / Q000378:metabolism; D008078:Cholesterol, LDL / Q000032:analysis / Q000378:metabolism*; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood* / Q000517:prevention & control*; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D012016:Reference Values; D012044:Regression Analysis; D018570:Risk Assessment; D012737:Sex Factors; D013030:Spain
chemical_list: D001055:Apolipoproteins B; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL