title: Ni-catalyzed cascade cyclization-Kumada alkyl-alkyl cross-coupling.
abstract: Suggesting novel disconnections: A powerful Ni-catalyzed cascade reaction involving cyclization followed by cross-coupling allows the formation of up to three alkyl-alkyl bonds in a single operation by using alkene-containing alkyl iodides and Grignard reagents (see scheme; acac = acetylacetonate; TMEDA = N,N',N'-tetramethyl ethylenediamine). Mechanistic experimental and computational studies suggest a Ni(I)-Ni(II)-Ni(III) catalytic cycle and the intermediacy of radicals.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid (UAM), Cantoblanco, 28049, Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Guisán-Ceinos
authors.forename: Rita
authors.initials: R
authors.lastname: Soler-Yanes
authors.forename: Daniel
authors.initials: D
authors.lastname: Collado-Sanz
authors.forename: Vilas B
authors.initials: VB
authors.lastname: Phapale
authors.forename: Elena
authors.initials: E
authors.lastname: Buñuel
authors.forename: Diego J
authors.initials: DJ
authors.lastname: Cárdenas