title: Connecting with an old partner in a new way.
abstract: In this issue of Cancer Cell, Hao and colleagues report a non-canonical interaction between the insulin receptor substrate 1 and certain oncogenic variants of the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K). A cell-penetrant peptide that disrupts this interaction downregulates PI3K signaling and inhibits tumor growth in mice.
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
authors.forename: John E
authors.initials: JE
authors.lastname: Burke
authors.forename: Roger L
authors.initials: RL
authors.lastname: Williams
mesh_terms: D058534:Class I Phosphatidylinositol 3-Kinases; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics*
chemical_list: C526292:IRS1 protein, human; D055504:Insulin Receptor Substrate Proteins; D019869:Phosphatidylinositol 3-Kinases; D058534:Class I Phosphatidylinositol 3-Kinases; C484760:PIK3CA protein, human