title: Molecular epidemiology of Coxsackievirus A16 strains isolated from children in Yamagata, Japan between 1988 and 2011.
abstract: To clarify the longitudinal molecular epidemiology of coxsackievirus A16, phylogenetic analysis based on the VP1 region of 220 isolates in Yamagata, Japan was performed. The resultant phylogenetic tree indicates that the Yamagata isolates and reference strains can be readily genotyped into three genogroups, and 0, 12 and 208 isolates belonged to the first, second, and third genogroups, respectively. The first genogroup includes only the prototype strain, the second strains that had disappeared by the end of the 20th century and the third comprises those that have been circulating since then in local communities, such as Yamagata.
authors.affiliation: Department of Microbiology, Yamagata Prefectural Institute of Public Health, Tokamachi 1-6-6, Yamagata 990-0031, Japan. mizutak@pref.yamagata.jp
authors.forename: Katsumi
authors.initials: K
authors.lastname: Mizuta
authors.forename: Chieko
authors.initials: C
authors.lastname: Abiko
authors.forename: Yoko
authors.initials: Y
authors.lastname: Aoki
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ikeda
authors.forename: Yoko
authors.initials: Y
authors.lastname: Matsuzaki
authors.forename: Seiji
authors.initials: S
authors.lastname: Hongo
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Itagaki
authors.forename: Noriko
authors.initials: N
authors.lastname: Katsushima
authors.forename: Akira
authors.initials: A
authors.lastname: Ohmi
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Nishimura
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Ahiko
mesh_terms: D002648:Child; D016000:Cluster Analysis; D003384:Coxsackievirus Infections / Q000453:epidemiology* / Q000821:virology*; D004770:Enterovirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007564:Japan / Q000453:epidemiology; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D012367:RNA, Viral