title: Leptin in thrombosis and atherosclerosis.
abstract: A world-wide obesity epidemic is threatening to have a major impact on the prevalence of chronic and acute vascular diseases. In addition to weight loss interventions, which have met with modest success to date, it will be important to understand mechanisms by which obesity promotes vascular disease processes. Studies of leptin, a hormone produced by the adipocyte, have supported the concept that adipocyte-specific products may be mediating some of the vascular risk associated with obesity. This mini-review provides an overview of some of the preclinical studies demonstrating causal relationships between leptin and vascular endpoints. Therapeutic strategies designed to block leptin-mediated signaling events in cells contributing to vascular disease may prove beneficial in obese subjects at risk for vascular complications.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Luo
authors.affiliation: University of Michigan Cardiovascular Research Center, 7301A MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0644, USA. deitzman@umich.edu.
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Eitzman
mesh_terms: D000818:Animals; D001158:Arteries / Q000378:metabolism*; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000097:blood / Q000378:metabolism*; D008955:Models, Cardiovascular; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D009765:Obesity / Q000503:physiopathology; D054411:Receptors, Leptin / Q000819:agonists* / Q000378:metabolism; D015398:Signal Transduction; D013927:Thrombosis / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D017539:Tunica Intima / Q000378:metabolism
chemical_list: C515448:LEPR protein, human; D020738:Leptin; D054411:Receptors, Leptin