title: Infective endocarditis caused by Enterococcus faecalis treated with continuous infusion of ampicillin without adjunctive aminoglycosides.
abstract: Aminoglycosides are useful antimicrobial agents for treating infective endocarditis; however, they occasionally cause troublesome side effects, such as nephrotoxicity and ototoxicity. We herein report a case of infective endocarditis caused by Enterococcus faecalis that was treated successfully with continuous infusion of ampicillin without adjunctive aminoglycosides. The serum ampicillin concentrations were higher than the minimal inhibitory concentration for the target strain. Although the use of ampicillin monotherapy is currently avoided because double β-lactam therapy is reportedly more effective, continuous penicillin administration remains an effective therapeutic choice for treating infective endocarditis.
authors.affiliation: Center for Infectious Diseases, Nara Medical University, Japan. t_ogawa@naramed-u.ac.jp
authors.forename: Taku
authors.initials: T
authors.lastname: Ogawa
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Sato
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Yonekawa
authors.forename: Chiyo
authors.initials: C
authors.lastname: Nakagawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Uno
authors.forename: Kei
authors.initials: K
authors.lastname: Kasahara
authors.forename: Koichi
authors.initials: K
authors.lastname: Maeda
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Konishi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Mikasa
mesh_terms: D000368:Aged; D000617:Aminoglycosides / Q000009:adverse effects; D000667:Ampicillin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D000925:Anticoagulants / Q000627:therapeutic use; D019644:Arthroplasty, Replacement, Hip; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy; D000075202:Contraindications; D003937:Diagnosis, Differential; D004697:Endocarditis, Bacterial / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D013293:Enterococcus faecalis / Q000187:drug effects / Q000302:isolation & purification*; D005265:Femoral Neck Fractures / Q000601:surgery; D016908:Gram-Positive Bacterial Infections / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008826:Microbial Sensitivity Tests; D008943:Mitral Valve / Q000382:microbiology; D011183:Postoperative Complications / Q000188:drug therapy / Q000382:microbiology; D017410:Practice Guidelines as Topic; D011704:Pyelonephritis / Q000175:diagnosis; D013307:Streptomycin; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D014859:Warfarin; D000667:Ampicillin; D013307:Streptomycin