title: Rapid antidepressant effects: moving right along.
abstract: Available treatments for depression have significant limitations, including low response rates and substantial lag times for response. Reports of rapid antidepressant effects of a number of compounds, including the glutamate N-methyl-D-aspartate receptor antagonist ketamine, have spurred renewed translational neuroscience efforts aimed at elucidating the molecular and cellular mechanisms of action that result in rapid therapeutic response. This perspective provides an overview of recent advances utilizing compounds with rapid-acting antidepressant effects, discusses potential mechanism of action and provides a framework for future research directions aimed at developing safe, efficacious antidepressants that achieve satisfactory remission not only by working rapidly but also by providing a sustained response.
authors.affiliation: Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
authors.forename: K
authors.initials: K
authors.lastname: Martinowich
authors.forename: D V
authors.initials: DV
authors.lastname: Jimenez
authors.forename: C A
authors.initials: CA
authors.lastname: Zarate
authors.forename: H K
authors.initials: HK
authors.lastname: Manji
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007649:Ketamine / Q000494:pharmacology* / Q000627:therapeutic use*; D008959:Models, Neurological; D015398:Signal Transduction / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D018691:Excitatory Amino Acid Antagonists; D007649:Ketamine