title: [Pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A in Carthami Flos].
abstract: OBJECTIVE
  To investigate the pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A (HSYA) in Carthami Flos.
  
  
  METHODS
  Concentration of HSYA in rat plasma was detected by RP-HPLC after rats were orally administered with extracts of Carthami Flos or Carthami Flos combined with Sappan Lignum. Pharmacokinetic parameters were calculated by DAS 2.0 pharmacokinetic software.
  
  
  RESULTS
  In vivo pharmacokinetic models of HSYA were two-compartment open models in both of the Carthami Flos group and the Carthami Flos combined with Sappan Lignum group. After compatibility, HSYA showed a significant lower in apparent volumes of distribution of t(1/2Ka), t(1/2alpha) and V1/F, with slight advance in T(max).
  
  
  CONCLUSIONS
  Sappan Lignum can accelerate absorption, distribution and metabolic process of HSYA in vivo and reduce its accumulation in vivo.
authors.affiliation: College of Life Sciences, Northwest University, Xi'an 710069, China. li_xiatcm@126.com
authors.forename: Li
authors.initials: L
authors.lastname: Xia
authors.forename: Xiang-Mei
authors.initials: XM
authors.lastname: Chen
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Peng
authors.forename: Shi-Xiang
authors.initials: SX
authors.lastname: Wang
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zuo
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Qin-She
authors.initials: QS
authors.lastname: Liu
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Zheng
mesh_terms: D000284:Administration, Oral; D000818:Animals; D029911:Caesalpinia / Q000737:chemistry*; D031187:Carthamus tinctorius / Q000737:chemistry*; D002599:Chalcone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005260:Female; D035264:Flowers / Q000737:chemistry; D008297:Male; D011809:Quinones / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013047:Specific Pathogen-Free Organisms; D014934:Wood / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D011809:Quinones; C085278:hydroxysafflor yellow A; D002599:Chalcone