title: Synthesis and cytotoxicity of some novel 21E-benzylidene steroidal derivatives.
abstract: A series of novel derivatives of 21E-benzylidene-pregn-1,4-diene-3,20-dione 7a-g and 21E-benzylidene-4-chloro-pregn-1,4-diene-3,20-dione 8a-g was synthesized from the commercially available progesterone. These title compounds were evaluated for their cytotoxic activity against brine shrimp (Artemia salina) and murine Lewis lung carcinoma cells (LLC). It was found that compounds 7a-g exhibited stronger activities than 8a-g against the brine shrimps, and some of the tested compounds possessed weak inhibition of LLC cells.
authors.affiliation: Shaanxi Engineering Center of Bio-Resource Chemistry & Sustainable Utilization, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Ning-Juan
authors.initials: NJ
authors.lastname: Fan
authors.forename: Yu-Bin
authors.initials: YB
authors.lastname: Bai
authors.forename: Fei-Yu
authors.initials: FY
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Luo
authors.forename: Jiang-Jiang
authors.initials: JJ
authors.lastname: Tang
authors.forename: Qiang-Zhe
authors.initials: QZ
authors.lastname: Zhang
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Gao
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001156:Artemia; D018827:Carcinoma, Lewis Lung; D045744:Cell Line, Tumor; D051379:Mice; D011374:Progesterone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D011374:Progesterone
keywords: Aldol reaction; Benzylidene steroidal derivatives; Cytotoxicity; Progesterone