title: Butyl methoxy dibenzoylmethane.
abstract: A comprehensive profile on Butyl methoxy dibenzoylmethane, one of the most commonly used ultraviolet (UV) filters in topical sunscreen products, is prepared. This UV filter, often referred to as Avobenzone, has its main absorbance in the UVA I region of the spectrum and is susceptible to photodegradation. The profile contains the following sections: general information, use and mechanism of action, method of preparation, physical characteristics, methods of analysis, stability, and toxicity. The physical characteristics section includes the melting range, differential scanning calorimetry, partition coefficient, ionization constant, solubility, and UV, infrared, nuclear magnetic resonance ((1)H NMR and (13)C NMR) and mass spectrometry and X-ray powder diffractometry. The method of analysis section in addition to compendial identification and purity and assay methods includes thin-layer gas and high-performance liquid chromatography. The photostability and photostabilization of Butyl methoxy dibenzoylmethane, in addition to its toxicity, are also documented.
authors.affiliation: School of Pharmacy and Molecular Science, James Cook University, Townsville, Queensland, Australia.
authors.forename: Jutta
authors.initials: J
authors.lastname: Kockler
authors.forename: Sherryl
authors.initials: S
authors.lastname: Robertson
authors.forename: Michael
authors.initials: M
authors.lastname: Oelgemöller
authors.forename: Murray
authors.initials: M
authors.lastname: Davies
authors.forename: Bruce
authors.initials: B
authors.lastname: Bowden
authors.forename: Harry G
authors.initials: HG
authors.lastname: Brittain
authors.forename: Beverley D
authors.initials: BD
authors.lastname: Glass
mesh_terms: D000473:Alkanes / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D047188:Chalcones / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D004355:Drug Stability; D006801:Humans; D011427:Propiophenones; D013057:Spectrum Analysis; D013473:Sunscreening Agents / Q000737:chemistry*
chemical_list: D000473:Alkanes; D047188:Chalcones; D011427:Propiophenones; D013473:Sunscreening Agents; C049935:avobenzone