title: Clinical and immunological features of 888 Brazilian systemic lupus patients from a monocentric cohort: comparison with other populations.
abstract: Epidemiological studies with systemic lupus erythematosus (SLE) patients have been reported worldwide but, until now, a large evaluation had not been performed in Brazil. Therefore, we determined the clinical and immunological features of 888 SLE patients followed at our service from 2008 to 2012. The mean age at SLE onset and the mean disease duration were 29.9 ± 9.5 years old and 14.5 ± 8.4 years, respectively. A predominance of female gender (91.9%) and Caucasian ethnicity (69.9%) were observed. Cumulative mucocutaneous manifestations (90.7%) were most commonly identified (malar rash (83.2%), photosensitivity (76.9%)) followed by articular (87.4%), hematological (44.0%) and renal (36.9%) involvements. Antinuclear antibody was detected in all patients, followed by anti-dsDNA (35.1%), anti-Sm (21.8%) and anti-ribosomal P protein antibodies (19.8%). Additional comparison of clinical and laboratory features between genders revealed that malar rash was observed more in female SLE patients (84.5% vs. 69.4%, p = 0.001). Male lupus patients presented a higher frequency of anti-dsDNA (45.8% vs. 34.2%, p = 0.047) and a trend of more nephritis (47.2% vs. 36.0%, p = 0.059). In conclusion, we identified a high prevalence of mucocutaneous manifestations in this Brazilian SLE cohort compared to other countries, mainly malar rash that was most commonly observed in female patients. Anti-dsDNA and other specific SLE autoantibodies were also identified in a higher frequency, predominantly in the male gender.
authors.affiliation: Division of Rheumatology, Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: E F
authors.initials: EF
authors.lastname: Borba
authors.forename: D B
authors.initials: DB
authors.lastname: Araujo
authors.forename: E
authors.initials: E
authors.lastname: Bonfá
authors.forename: S K
authors.initials: SK
authors.lastname: Shinjo
mesh_terms: D000328:Adult; D017668:Age of Onset; D000974:Antibodies, Antinuclear / Q000276:immunology*; D001938:Brazil / Q000453:epidemiology; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000453:epidemiology*; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology*; D008181:Lupus Nephritis / Q000453:epidemiology*; D008297:Male; D015995:Prevalence; D012737:Sex Factors; D055815:Young Adult
chemical_list: D000974:Antibodies, Antinuclear; D004247:DNA
keywords: Anti-DNA; autoantibody; gender; malar rash; systemic lupus erythematosus