title: [Quetiapine].
abstract: Quetiapine is a unique antipsychotic drug characterized by the weakest affinity for dopamine D2 receptors of all the antipsychotics. This drug certainly binds D2 receptors, but rapidly dissociates from them. Therefore, it is necessary to establish how to use quetiapine in the different way from potent and sustained D2 receptor antagonists such as haloperidol. Plenty dose of quetiapine is effective for schizophrenia patients suffered from severe insomnia, catatonia, emotional instability, impulsiveness and aggressiveness. However, in order to avoid metabolic side effects including weight gain and diabetes mellitus, we have to continue a longitudinal blood glucose monitoring in schizophrenia patients treated with quetiapine.
authors.affiliation: Department of Psychiatry, Hokkaido University Graduate School of Medicine.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kusumi
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001786:Blood Glucose / Q000187:drug effects; D003987:Dibenzothiazepines / Q000009:adverse effects / Q000627:therapeutic use*; D065127:Dopamine D2 Receptor Antagonists; D006801:Humans; D000069348:Quetiapine Fumarate; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D001786:Blood Glucose; D003987:Dibenzothiazepines; D065127:Dopamine D2 Receptor Antagonists; D000069348:Quetiapine Fumarate