title: Bilateral lesions of the nigrostriatal pathways are associated with chronic mechanical pain hypersensitivity in rats.
abstract: Some patients with Parkinson's disease (PD) suffer from pain before motor symptoms. To model this, we proposed to assess the mechanical hypersensitivity in an animal model of PD with a bilateral lesion of the nigrostriatal pathway. PD model was validated by a decrease of locomotor activity and a 76% dopamine cell loss in the substantia nigra pars compacta. PD animals displayed a decrease of mechanical thresholds, correlated with the degree of the dopamine lesion. This animal model displays nociceptive disorders as found in PD patients and could be useful to assess the effects of new antiparkinsonian drugs.
authors.affiliation: Clermont Université, Université d'Auvergne, EA 7280, BP 38, F-63001 Clermont-Ferrand, France. zengin_yildiz@hotmail.fr
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Zengin-Toktas
authors.forename: Jérémy
authors.initials: J
authors.lastname: Ferrier
authors.forename: Franck
authors.initials: F
authors.lastname: Durif
authors.forename: Pierre-Michel
authors.initials: PM
authors.lastname: Llorca
authors.forename: Nicolas
authors.initials: N
authors.lastname: Authier
mesh_terms: D000818:Animals; D059350:Chronic Pain / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D009043:Motor Activity; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013378:Substantia Nigra / Q000378:metabolism* / Q000473:pathology
chemical_list: D004298:Dopamine
keywords: 6-OHDA; Animal model; Electronic von Frey test; Pain; Parkinson's disease