title: Genome-brain-behavior interdependencies as a framework to understand hormone effects on learned behavior.
abstract: Hormones have profound effects on the maturation and function of the zebra finch song system. Hormones often signal through receptors that directly or indirectly regulate transcription. In this way, hormones and the genome are functionally connected. Genome-brain-behavior interdependencies are often studied on evolutionary timescales but we can now apply and test these relationships on short timescales, relevant to an individual. Here, we begin to place patterns of hormone-related gene expression into the timeframe of an individual's lifespan to consider how hormones contribute to organization of neural systems necessary for learned behavior, and how they might signal during experience in ways that affect future behavior. This framework illustrates both how much investigations into genome and hormone function are intertwined, and how much we still need to learn.
authors.affiliation: Department of Psychology, Institute for Mind and Biology, Committee on Neurobiology, University of Chicago, 129A BPSB, 940 E 57th Street, Chicago, IL 60637, USA. london@uchicago.edu
authors.forename: Sarah E
authors.initials: SE
authors.lastname: London
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D016678:Genome / Q000235:genetics*; D009479:Neuropeptides / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D020308:Songbirds / Q000378:metabolism* / Q000502:physiology
chemical_list: D009479:Neuropeptides; D018377:Neurotransmitter Agents
keywords: Behavior; Genome; Hormone; Neuropeptide; Neurosteroid; Songbird