title: CYP19A1 gene polymorphisms and risk of lung cancer.
abstract: OBJECTIVE
  To investigate the association between polymorphisms of aromatase (encoded by the CYP19A1 gene and a key enzyme in biosynthesis of oestradiol) and the risk of lung cancer, and whether there were differences stratified by sex and smoking history.
  
  
  METHODS
  This case-control study included consecutive, nonselected and pathologically-confirmed lung cancer patients and healthy people. Participants were classed as nonsmokers or smokers by questionnaire. Peripheral blood samples from all participants were genotyped for three single-nucleotide polymorphism (SNPs; rs727479, rs730154 and rs10046); allelic frequencies were compared across genotype and clinical records.
  
  
  RESULTS
  A total of 529 patients with lung cancer and 567 age- and sex-matched controls were included. After adjustment for age, sex and smoking history, rs727479 was significantly associated with the incidence of lung cancer (for alleles AC vs AA). There was also a significant difference between patients and controls in haplotype CCA, while haplotype ACA was only significantly associated with nonsmokers and female nonsmokers.
  
  
  CONCLUSIONS
  Polymorphisms of CYP19A1 may be related to the increased risk of lung cancer; in particular, haplotype ACA may contribute to lung-cancer progression in nonsmokers. Further validation with larger populations is required.
authors.affiliation: Department of Thoracic Surgery, Shanghai Cancer Hospital, Fudan University, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Yue
authors.initials: Y
authors.lastname: Yin
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Niu
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.forename: David
authors.initials: D
authors.lastname: Garfield
authors.forename: Su-Feng
authors.initials: SF
authors.lastname: Chen
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Hai-Quan
authors.initials: HQ
authors.lastname: Chen
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000235:genetics*; D000367:Age Factors; D000368:Aged; D000483:Alleles; D001141:Aromatase / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012737:Sex Factors; D055752:Small Cell Lung Carcinoma / Q000209:etiology / Q000235:genetics*; D012907:Smoking / Q000009:adverse effects
chemical_list: D001141:Aromatase; C561410:CYP19A1 protein, human
keywords: CYP19A1; Lung cancer; allele; aromatase; frequency; genotype; haplotype; single-nucleotide polymorphism