title: Influence of micro- and nano-hydroxyapatite coatings on the osteointegration of metallic (Ti6Al4 V) and bioabsorbable interference screws: an in vivo study.
abstract: The purpose of this study is to show and compare the fixation and osteointegration capability of metallic and bioabsorbable interference screws. For this, 8×20-mm interference screws were implanted into the bone tunnel in the proximal tibial metaphysis of sheep. The nano- (25 nm±0.8) and microscale (25 μm±0.5) hydroxyapatite were both dip-coated on Ti6Al4 V interference screws via an in vivo study. After the initial 12 weeks of postoperative, the pullout test, histopathology, X-ray diffraction and scanning electron microscopy examinations were performed. This multidisiplined work showed that the coated screws particularly those with nano-sized-HA coating and the bioabsorbable screws enhanced fixation and provided better stabilization, bone ingrowth and osteointegration than that of uncoated and microscale HA-coated screws. The bioabsorbable screws showed better histopathologic results.
authors.affiliation: Department of Materials and Metallurgical Engineering, Faculty of Chemistry and Metallurgy, Yildiz Technical University, Istanbul, Turkey, baksakal@yildiz.edu.tr.
authors.forename: B
authors.initials: B
authors.lastname: Aksakal
authors.forename: M
authors.initials: M
authors.lastname: Kom
authors.forename: H B
authors.initials: HB
authors.lastname: Tosun
authors.forename: M
authors.initials: M
authors.lastname: Demirel
mesh_terms: D020341:Absorbable Implants; D000497:Alloys; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001863:Bone Screws; D017886:Durapatite / Q000494:pharmacology*; D004867:Equipment Design; D005593:Fracture Fixation, Internal / Q000379:methods; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D016348:Osseointegration / Q000502:physiology*; D012756:Sheep; D013977:Tibia / Q000601:surgery* / Q000648:ultrastructure; D014025:Titanium
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; C031462:titanium alloy (TiAl6V4); D017886:Durapatite; D014025:Titanium