title: Rostral anterior cingulate activity in major depressive disorder: state or trait marker of responsiveness to medication?
abstract: High rostral anterior cingulate cortex (rACC) activity has been shown to predict antidepressant treatment response; however, it is unclear whether this is a fixed versus variable marker of responsiveness. The authors measured rACC theta current density in 22 subjects 5 weeks before and again immediately before 5 weeks of blinded treatment with sertraline. Mixed-effects regression analysis found that the relationship between response and rACC activity depended significantly on the timing of the rACC assessment; rACC activity measured immediately before treatment was a significantly better predictor of response. rACC activity may constitute a variable "state" indicator of responsiveness to antidepressants.
authors.affiliation: Laboratory of Brain, Behavior, and Pharmacology, and UCLA Depression Research & Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA. amhunter@ucla.edu
authors.forename: Aimee M
authors.initials: AM
authors.lastname: Hunter
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Korb
authors.forename: Ian A
authors.initials: IA
authors.lastname: Cook
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Leuchter
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D018592:Cross-Over Studies; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000473:pathology*; D004311:Double-Blind Method; D005260:Female; D006179:Gyrus Cinguli / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D013826:Theta Rhythm / Q000187:drug effects / Q000502:physiology*; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents