title: Current achievements with topical negative pressure to improve wound healing in dehiscent ischemic stumps of diabetic patients: a case series.
abstract: Negative pressure wound therapy has been increasingly used either as a primary or as an adjunctive therapeutic measure to treat a variety of recalcitrant wounds during the past years. It is thought to act by creating a local environment that promotes cell proliferation, angiogenesis, and granulation tissue formation, leading to accelerated wound healing to the point of spontaneous closure or reducing the wound size to facilitate significantly further surgical reconstruction. This case series presents our preliminary experience with the use of a Topical Negative Pressure system in the treatment of challenging ischemic wounds of diabetic patients. It aims to underscore its beneficial effects and explore its potential role in the management of ischemic amputated stumps to avoid ipsilateral re-amputation at a higher level.
authors.affiliation: Department of Vascular Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, Greece. efstratiosgeorg@gmail.com
authors.forename: Efstratios
authors.initials: E
authors.lastname: Georgakarakos
authors.forename: Dimitris
authors.initials: D
authors.lastname: Charalampidis
authors.forename: Despoina
authors.initials: D
authors.lastname: Kakagia
authors.forename: George S
authors.initials: GS
authors.lastname: Georgiadis
authors.forename: Miltos K
authors.initials: MK
authors.lastname: Lazarides
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papanas
mesh_terms: D000368:Aged; D000672:Amputation Stumps; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D017719:Diabetic Foot / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy; D013529:Surgical Wound Dehiscence / Q000473:pathology / Q000628:therapy*; D014945:Wound Healing
keywords: diabetes; granulation; ischemia; negative pressure treatment; wound healing