title: Emerging roles for miRNAs in the development, diagnosis, and treatment of diabetic nephropathy.
abstract: Although the causes of diabetic nephropathy are not yet fully known, emerging evidence suggests a role for epigenetic factors in the development of the disease. In particular, microRNAs (miRNAs) are becoming recognized as important mediators of biological processes relevant to diabetic nephropathy. Until recently, investigations of miRNAs in the development of diabetic nephropathy have remained relatively limited; however, the number of reports identifying potential new candidates and mechanisms of impact is presently expanding at a rapid pace. This review seeks to summarize these recent findings, focusing on new candidates and/or novel mechanisms, including the intersection between genetic variation and miRNA function in modulating disease expression, emerging in the field. We also review the latest advances in the diagnostic and therapeutic potential of miRNAs in the treatment of diabetic nephropathy.
authors.affiliation: Diabetes, Cardiovascular and Metabolic Diseases Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA. jdistefano@tgen.org
authors.forename: Johanna K
authors.initials: JK
authors.lastname: DiStefano
authors.forename: Matthew
authors.initials: M
authors.lastname: Taila
authors.forename: M Lucrecia
authors.initials: ML
authors.lastname: Alvarez
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D018450:Disease Progression; D014644:Genetic Variation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs