title: Identification of brachyspina syndrome carriers in Chinese Holstein cattle.
abstract: Brachyspina syndrome (BS) is a rare monogenic autosomal recessive hereditary disorder identified in the Holstein breed caused by a 3.3-kb deletion in the bovine Fanconi anemia complementation group I (FANCI) gene on chromosome 21. In previous reports, the BS mutant allele was identified in North American and European Holstein populations. Because frozen semen and embryos have been imported into China from such regions during the past few years, BS has potentially spread into the dairy cattle population in China. In the present study, 206 Holstein bulls and 136 Holstein cows were tested for BS, with 10 BS carrier bulls and 3 carrier cows identified. Pedigree analysis showed that all 10 BS carrier bulls could be traced back to a common ancestor, the U.S. Holstein sire Sweet Haven Tradition. It is recommended that effective selection and mating strategies should be carried out to gradually eliminate this recessive gene from the Chinese Holstein population.
authors.affiliation: Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
authors.forename: Lingzhao
authors.initials: L
authors.lastname: Fang
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Dongxiao
authors.initials: D
authors.lastname: Sun
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shengli
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002353:Carrier State / Q000473:pathology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics* / Q000473:pathology; D002681:China; D004247:DNA / Q000737:chemistry / Q000235:genetics; D051856:Fanconi Anemia Complementation Group Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D008297:Male; D010375:Pedigree; D016133:Polymerase Chain Reaction / Q000662:veterinary; D017384:Sequence Deletion / Q000235:genetics*
chemical_list: D051856:Fanconi Anemia Complementation Group Proteins; D004247:DNA
keywords: Brachyspina syndrome; Holstein cattle; genetic defect; polymerase chain reaction