title: [Cutaneous adverse reactions of EGFR (epidermal growth factor receptor)-inhibitors: therapeutic algorithm of the French PROCUR group].
abstract: The epidermal growth factor receptors (EGFR)-inhibitors are frequently responsible for cutaneous adverse drug reactions that may alter the patients' quality of life and hamper the continuation of treatment. We present here the experience of a group of French multidisciplinary experts - the PROCUR group (PRise en charge de la tOxicité CUtanée des anti-EGFR) - created in order to establish a therapeutic algorithm. It was built in three steps under the responsibility of a steering committee: (1) a systematic literature review was performed by a group of three dermatologists and one oncologist; (2) regional meetings evaluated practical aspect of the treatments in France; (3) a final meeting confrontating the practices in France and the evidence-based medicine including the steering committee, the bibliographic group, and oncologists, radiotherapists, dermatologists and hepato-gastroenterologists involved in regional scientific committees, resulted in a therapeutic algorithm, resulting in the collegial writing of this algorithm. This multidisciplinary study should facilitate the standardised, optimised management of skin toxicity associated with EGFR-inhibitors.
authors.affiliation: Assistance publique-Hôpitaux de Paris, hôpital Tenon, service de médecine interne, 4, rue de la Chine, 75020 Paris, France. claude.bachmeyer@tnn.aphp.fr
authors.forename: Claude
authors.initials: C
authors.lastname: Bachmeyer
authors.forename: Ziad
authors.initials: Z
authors.lastname: Reguiaï
authors.forename: Lucie
authors.initials: L
authors.lastname: Peuvrel
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Bachet
authors.forename: René-Jean
authors.initials: RJ
authors.lastname: Bensadoun
authors.forename: Marc
authors.initials: M
authors.lastname: Ychou
authors.forename: Thierry
authors.initials: T
authors.lastname: André
authors.forename: Olivier
authors.initials: O
authors.lastname: Bouché
authors.forename: Brigitte
authors.initials: B
authors.lastname: Dréno
mesh_terms: D000465:Algorithms; D003875:Drug Eruptions / Q000145:classification / Q000209:etiology / Q000628:therapy*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D019317:Evidence-Based Medicine; D005499:Folliculitis / Q000209:etiology / Q000628:therapy; D005602:France; D006801:Humans; D011855:Radiodermatitis / Q000209:etiology / Q000628:therapy
chemical_list: D066246:ErbB Receptors
keywords: EGFR-inhibitors; cutaneous adverse drug reactions; therapeutic algorithm