title: Evidence for novel aspects of Nox4 oxidase regulation of mitochondrial function and peroxide generation in an endothelial cell model of senescence.
abstract: Observations by Kozieł et al. reported in this issue of the Biochemical Journal suggest the existence of novel regulatory processes associated with new evidence for increased Nox4 (NAPDH oxidase 4) regulation of mitochondrial function in a cultured endothelial cell aging-induced senescence model. Cellular aging appears to promote a Nox4 interaction with mitochondria that disrupts complex I in the electron transport chain and increases the detection of mitochondrial H(2)O(2). Nox4 appears to maintain a highly interconnected mitochondrial network, which may influence mitochondrial fission and/or fusion mechanisms in a manner that could be a contributing factor in the loss of replicative lifespan seen in senescence.
authors.affiliation: Department of Physiology and Pulmonary Hypertension Center, New York Medical College, Valhalla, NY 10595, USA. mike_wolin@nymc.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Wolin
mesh_terms: D042967:Electron Transport Complex I / Q000037:antagonists & inhibitors*; D006801:Humans; D000074663:NADPH Oxidase 4; D019255:NADPH Oxidases / Q000737:chemistry* / Q000502:physiology*
chemical_list: D000074663:NADPH Oxidase 4; D019255:NADPH Oxidases; C498910:NOX4 protein, human; D042967:Electron Transport Complex I