title: Effect of normal saline administration on circulation stability during general anesthesia induction with propofol in gynecological procedures - randomised-controlled study.
abstract: OBJECTIVE
  To compare the effect of prophylactic administration of normal saline against the hypotensive effect of propofol in female patients booked for gynecological procedures.
  
  
  METHODS
  Sixty nine ASA (I, II) patients were randomly allocated into two groups, group 1 received 5mL.kg(-1) of 0.9% normal saline 10 minutes before induction, whereas group 2 received nothing (control). Anesthesia was induced with propofol and fentanyl then maintained with propofol and remifentanil. We measured hemodynamic variables pre and post general anesthesia induction.
  
  
  RESULTS
  Both groups had significant drops in post induction mean arterial blood pressure (P<0.001). Also both groups had significant drops in post induction heart rate ((P<0.02 in sample group and P<0.001 in control group), and 35% of patients in the control group had more than 25% drop in the pre induction mean arterial blood pressure, compared with only 17% of patients in the saline group (P<0.04).
  
  
  CONCLUSIONS
  The prophylactic administration of normal saline could decrease the percentage of patients who had a significant drop in their blood pressure after propofol induction of general anesthesia.
authors.affiliation: Department of Anesthesiology, Jordan University of Science & Technology, Irbid, Jordan. daherrabadi@yahoo.com.au
authors.forename: Daher
authors.initials: D
authors.lastname: Rabadi
mesh_terms: D000768:Anesthesia, General; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000517:prevention & control*; D015742:Propofol / Q000009:adverse effects*; D011446:Prospective Studies; D016037:Single-Blind Method; D012965:Sodium Chloride / Q000627:therapeutic use*
chemical_list: D018686:Anesthetics, Intravenous; D012965:Sodium Chloride; D015742:Propofol