title: Age-dependent alteration in muscle regeneration: the critical role of tissue niche.
abstract: Although adult skeletal muscle is composed of fully differentiated fibers, it retains the capacity to regenerate in response to injury and to modify its contractile and metabolic properties in response to changing demands. The major role in the growth, remodeling and regeneration is played by satellite cells, a quiescent population of myogenic precursor cells that reside between the basal lamina and plasmalemma and that are rapidly activated in response to appropriate stimuli. However, in pathologic conditions or during aging, the complete regenerative program can be precluded by fibrotic tissue formation and resulting in functional impairment of the skeletal muscle. Our study, along with other studies, demonstrated that although the regenerative program can also be impaired by the limited proliferative capacity of satellite cells, this limit is not reached during normal aging, and it is more likely that the restricted muscle repair program in aging is presumably due to missing signals that usually render the damaged muscle a permissive environment for regenerative activity.
authors.affiliation: Institute Pasteur Cenci-Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, IIM, Sapienza University of Rome, Rome, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Barberi
authors.forename: Bianca Maria
authors.initials: BM
authors.lastname: Scicchitano
authors.forename: Manuela
authors.initials: M
authors.lastname: De Rossi
authors.forename: Anne
authors.initials: A
authors.lastname: Bigot
authors.forename: Stephanie
authors.initials: S
authors.lastname: Duguez
authors.forename: Aurore
authors.initials: A
authors.lastname: Wielgosik
authors.forename: Claire
authors.initials: C
authors.lastname: Stewart
authors.forename: Jamie
authors.initials: J
authors.lastname: McPhee
authors.forename: Maria
authors.initials: M
authors.lastname: Conte
authors.forename: Marco
authors.initials: M
authors.lastname: Narici
authors.forename: Claudio
authors.initials: C
authors.lastname: Franceschi
authors.forename: Vincent
authors.initials: V
authors.lastname: Mouly
authors.forename: Gillian
authors.initials: G
authors.lastname: Butler-Browne
authors.forename: Antonio
authors.initials: A
authors.lastname: Musarò
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001706:Biopsy; D049109:Cell Proliferation; D002478:Cells, Cultured; D019941:Cyclin-Dependent Kinase Inhibitor p16; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D009363:Neoplasm Proteins / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D055948:Sarcopenia / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D032496:Satellite Cells, Skeletal Muscle / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D016615:Telomere / Q000648:ultrastructure; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D055815:Young Adult
chemical_list: C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D009363:Neoplasm Proteins; D016159:Tumor Suppressor Protein p53