title: [Current status of epigenetics of schizophrenia].
abstract: The patients with schizophrenia suffer from a lot of severe symptoms; positive symptoms, negative symptoms and cognitive impairment. However, the pathophysiology remains almost unknown, and no curative therapy is available for the patients. Thus, the elucidation of the pathophysiology and development of curative therapy are imperative. Epigenetics is a promising approach in that it can explain the environmental effects as well as gene-environmental interaction. Here, we review the recent progress of epigenetic studies in relation to schizophrenia and discuss the limitation of previous studies. Epigenetic studies applying the recent progress of genomics and neuroscience will contribute to better understanding of schizophrenia pathophysiology and the development of therapeutic strategy.
authors.affiliation: Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo.
authors.forename: Masaki
authors.initials: M
authors.lastname: Nishioka
authors.forename: Miki
authors.initials: M
authors.lastname: Bundo
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
authors.forename: Kazuya
authors.initials: K
authors.lastname: Iwamoto
mesh_terms: D001344:Autopsy / Q000379:methods; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis / Q000235:genetics*