title: Synthesis and characterization of [M(III)(PS)2(L)] mixed-ligand compounds (M = Re, 99Tc; PS = phosphinothiolate; L = dithiocarbamate) as potential models for the development of new agents for SPECT imaging and radiotherapy.
abstract: The synthesis and characterization of a new series of neutral, six-coordinated mixed-ligand compounds [M(III)(PS)2(L)] (M = Re; (99)Tc), where PS is bis(arylalkyl)- or trialkylphosphinothiolate and L is dithiocarbamate, are reported. Stable [M(III)(PS)2(L)] complexes were easily synthesized, in good yield, starting from precursors where the metal was in different oxidation states (III, V, and VII), involving ligand-exchange and/or redox-substitution reactions. The compounds were characterized by elemental analysis, positive-ion electrospray ionization mass spectrometry, multinuclear NMR spectroscopy, cyclic voltammetry, and X-ray diffraction analysis. All complexes are constituted by the presence of the [M(III)(PS)2](+) moiety, where two phosphinothiolate ligands are tightly bound to the metal and the remaining two positions are saturated by a dithiocarbamate chelate, also carrying bulky bioactive molecules [e.g., (2-methoxyphenyl)piperazine]. X-ray analyses were performed on crystalline specimens of four different Re/(99)Tc compounds sharing a distorted trigonal-prismatic geometry, with a P2S4 coordination donor set. The possibility of easily preparing these [M(III)(PS)2(L)] complexes, starting from the corresponding permetalate anions, in mild reaction conditions and in high yield, lays the first stone to the preparation of a new series of M(III)-based (M = (99m)Tc/(188)Re) compounds potentially useful in theragnostic applications.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università di Padova, Via Marzolo 5, 35131 Padova, Italy. nicola.salvarese@unipd.it
authors.forename: N
authors.initials: N
authors.lastname: Salvarese
authors.forename: N
authors.initials: N
authors.lastname: Morellato
authors.forename: A
authors.initials: A
authors.lastname: Venzo
authors.forename: F
authors.initials: F
authors.lastname: Refosco
authors.forename: A
authors.initials: A
authors.lastname: Dolmella
authors.forename: C
authors.initials: C
authors.lastname: Bolzati
mesh_terms: D002219:Carbamates / Q000737:chemistry; D018360:Crystallography, X-Ray; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry / Q000627:therapeutic use*; D010720:Phosphines / Q000737:chemistry; D012211:Rhenium / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013667:Technetium / Q000737:chemistry; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D002219:Carbamates; D008024:Ligands; D009942:Organometallic Compounds; D010720:Phosphines; D013438:Sulfhydryl Compounds; D012211:Rhenium; D013667:Technetium