title: Hydroxyapatite/poly-L-lactide acid screws have better biocompatibility and femoral burr hole closure than does poly-L-lactide acid alone.
abstract: Hydroxyapatite (HA)/poly-l-lactide(PLLA) composite biomaterials are available for orthopedic applications, but bioresorption and cell-mediated inflammation in bone cortex are unknown. We conducted an 84-month follow-up study with Beagle dogs that were subjected to implants with either PLLA (left femur) or HA/PLLA (right femur). Histological and radiographic analysis showed that HA/PLLA screws induced significant increases in HA content from 36 months onward and complete burr hole closure at 60 months, whereas PLLA screws did not. Moreover, PLLA screws induced more severe fibrous tissue and histiocyte infiltration. HA/PLLA screws promote earlier burr hole replacement and have superior biocompatibility compared to PLLA screws.
authors.affiliation: 1Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Akagi
authors.forename: Munetaka
authors.initials: M
authors.lastname: Iwata
authors.forename: Tomu
authors.initials: T
authors.lastname: Ichinohe
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Amimoto
authors.forename: Yuuta
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kannno
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ochi
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Fujita
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Harada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tagawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hara
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001863:Bone Screws; D001842:Bone and Bones / Q000000981:diagnostic imaging; D004285:Dogs; D017886:Durapatite; D008297:Male; D011091:Polyesters; D014057:Tomography, X-Ray Computed
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide); D017886:Durapatite
keywords: Biomaterial; foreign body reaction; hydroxyapatite; orthopedics; poly-l-lactide