title: [Fourth generation oral contraceptives are associated with a higher risk of venous thromboembolism compared to second generation].
abstract: It has been widely discussed whether fourth generation oral contraceptives (OC) are associated with a higher risk of venous thromboembolism (VTE) compared to second generation. Lack of randomized controlled trials, methodological problems and inconsistent criteria for the VTE event has led to conflicting results. Three newly published studies utilising improved methodology show that fourth generation OC are associated with an increased risk of VTE compared to second generation OC. This knowledge has led to a change in recommendation of the first drug of choice, which is now second generation OC.
authors.affiliation: Klinisk Farmakologisk Afdeling, Aarhus Universitetshospital, Denmark. marlenelunddalkrogh@gmail.com
authors.forename: Marlene Lunddal
authors.initials: ML
authors.lastname: Krogh
authors.forename: Birgitte Klindt
authors.initials: BK
authors.lastname: Poulsen
mesh_terms: D000293:Adolescent; D000328:Adult; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D000451:Mineralocorticoid Receptor Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000139:chemically induced*
chemical_list: D003280:Contraceptives, Oral, Synthetic; D000451:Mineralocorticoid Receptor Antagonists