title: Intraoperative corneal thickness measurements during corneal collagen cross-linking with isotonic riboflavin solution without dextran in corneal ectasia.
abstract: Abstract Objective: To monitor the changes in corneal thickness during the corneal collagen cross-linking procedure by using isotonic riboflavin solution without dextran in ectatic corneal diseases.
  
  
  METHODS
  The corneal thickness measurements were obtained before epithelial removal, after epithelial removal, following the instillation of isotonic riboflavin solution without dextran for 30 min, and after 10 min of ultraviolet A irradiation.
  
  
  RESULTS
  Eleven eyes of eleven patients with progressive keratoconus (n = 10) and iatrogenic corneal ectasia (n = 1) were included in this study. The mean thinnest pachymetric measurements were 391.82 ± 30.34 µm (320-434 µm) after de-epithelialization of the cornea, 435 ± 21.17 µm (402-472 µm) following 30 min instillation of isotonic riboflavin solution without dextran and 431.73 ± 20.64 µm (387-461 µm) following 10 min of ultraviolet A irradiation to the cornea.
  
  
  CONCLUSIONS
  Performing corneal cross-linking procedure with isotonic riboflavin solution without dextran might not induce corneal thinning but a little swelling throughout the procedure.
authors.affiliation: Department of Ophthalmology, School of Medicine, Dicle University, Diyarbakir , Turkey.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Cınar
authors.forename: Abdullah Kürşat
authors.initials: AK
authors.lastname: Cingü
authors.forename: Alparslan
authors.initials: A
authors.lastname: Sahin
authors.forename: Fatih Mehmet
authors.initials: FM
authors.lastname: Türkcü
authors.forename: Harun
authors.initials: H
authors.lastname: Yüksel
authors.forename: Ihsan
authors.initials: I
authors.lastname: Caca
mesh_terms: D003094:Collagen / Q000378:metabolism*; D003316:Corneal Diseases / Q000188:drug therapy / Q000601:surgery*; D003319:Corneal Stroma / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D019781:Corneal Topography; D003432:Cross-Linking Reagents / Q000627:therapeutic use*; D003911:Dextrans / Q000737:chemistry; D004108:Dilatation, Pathologic / Q000188:drug therapy / Q000601:surgery*; D019573:Epithelium, Corneal / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D007430:Intraoperative Care; D007552:Isotonic Solutions; D007640:Keratoconus / Q000188:drug therapy / Q000601:surgery; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012256:Riboflavin / Q000627:therapeutic use*; D014466:Ultraviolet Rays
chemical_list: D003432:Cross-Linking Reagents; D003911:Dextrans; D007552:Isotonic Solutions; D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin