title: Iranian Registry of Clinical Trials two years on and the timing of registrations.
abstract: The Iranian Registry of Clinical Trials (IRCT) was established as a primary registry on December 4 2008 and has registered over 1350 trials by June 2011. Many researchers are still unaware of the need for registration of trials before recruiting the first patient and the proportion of retrospectively registered trials is likely to grow until this awareness increases. We sought to investigate the timing of the registrations in IRCT and to explore strategies to overcome this. We used all data in the IRCT database and extracted the date of registration, as well as the dates for the start and the end of recruitment. We categorized trials into 4 groups: those registered before the start of patient enrolment, within 30 days of enrolment, after 30 days but before the end of recruitment, and after the end of recruitment. The proportion of trials in each category was calculated by calendar year. The number of registered trials increased from 26 in the 3 months leading to 2009 to 181 in 2009, 772 in 2010 and 376 in the first 5 months of 2011 (estimate by end of year = 947). The proportions of trials registered after the end of patient recruitment were 55%, 58% and 62% in 2009, 2010 and 2011 respectively. On average, 6.4% of trials were registered within 30 days from the start of patient recruitment and 27% in the time between then and the end of recruitment. The rapid increase in the number of registered trials is an indication of strong implementation of the registration policy. This comes partly at the expense of an increased proportion of retrospective registrations. While this may be understandable at the beginning, it is clearly not acceptable and measures should be adopted to increase the proportion of prospectively registered trials and to make trial registration an integral part of the research culture.
authors.affiliation: Minimally Invasive Surgery Research Center, Rassoul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran. msolaymani@tums.ac.ir
authors.forename: Masoud
authors.initials: M
authors.lastname: Solaymani-Dodaran
authors.forename: Davood
authors.initials: D
authors.lastname: Khalili
authors.forename: Hamed
authors.initials: H
authors.lastname: Hosseini
authors.forename: Laily
authors.initials: L
authors.lastname: Najafi
authors.forename: Kourosh
authors.initials: K
authors.lastname: Kamali
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Ranjbar
authors.forename: Hassan
authors.initials: H
authors.lastname: Tavakoli
authors.forename: Afshin
authors.initials: A
authors.lastname: Ostovar
mesh_terms: D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D006801:Humans; D007492:Iran; D012042:Registries / Q000706:statistics & numerical data*; D013997:Time Factors