title: CD147 in regulatory T cells.
abstract: CD147 or EMMPRIN belongs to the immunoglobulin superfamily of membrane receptors and is expressed in epithelial cells, cancer cells and T cells of the immune system. In T cells CD147 functions as a receptor for soluble cyclophilins and is involved in chemotaxis. We recently reported its expression to high levels and association with suppressive function in regulatory T cells. Here, we discuss its potential application as a marker of activated regulatory T cells.
authors.affiliation: Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, P.O. Box 1125 Blindern, N-0318 Oslo, Norway.
authors.forename: Johannes
authors.initials: J
authors.lastname: Landskron
authors.forename: Kjetil
authors.initials: K
authors.lastname: Taskén
mesh_terms: D000818:Animals; D051926:Basigin / Q000276:immunology* / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology* / Q000378:metabolism
chemical_list: D015415:Biomarkers; D053645:Interleukin-2 Receptor alpha Subunit; D051926:Basigin