title: Solvent-free synthesis, spectral correlations and antimicrobial activities of some aryl E 2-propen-1-ones.
abstract: Totally 38 aryl E 2-propen-1-ones including nine substituted styryl 4-iodophenyl ketones have been synthesised using solvent-free SiO2-H3PO4 catalyzed Aldol condensation between respective methyl ketones and substituted benzaldehydes under microwave irradiation. The yields of the ketones are more than 80%. The synthesised chalcones were characterized by their analytical, physical and spectroscopic data. The spectral frequencies of synthesised substituted styryl 4-iodophenyl ketones have been correlated with Hammett substituent constants, F and R parameters using single and multi-linear regression analysis. The antimicrobial activities of 4-iodophenyl chalcones have been studied using Bauer-Kirby method.
authors.affiliation: PG & Research Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram 608 102, India.
authors.forename: K
authors.initials: K
authors.lastname: Sathiyamoorthi
authors.forename: V
authors.initials: V
authors.lastname: Mala
authors.forename: S P
authors.initials: SP
authors.lastname: Sakthinathan
authors.forename: D
authors.initials: D
authors.lastname: Kamalakkannan
authors.forename: R
authors.initials: R
authors.lastname: Suresh
authors.forename: G
authors.initials: G
authors.lastname: Vanangamudi
authors.forename: G
authors.initials: G
authors.lastname: Thirunarayanan
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002384:Catalysis; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006801:Humans; D009181:Mycoses / Q000188:drug therapy
chemical_list: D000475:Alkenes; D000890:Anti-Infective Agents; D047188:Chalcones; C013658:propylene