title: Inter-subject alignment of human cortical anatomy using functional connectivity.
abstract: Inter-subject alignment of functional MRI (fMRI) data is necessary for group analyses. The standard approach to this problem matches anatomical features of the brain, such as major anatomical landmarks or cortical curvature. Precise alignment of functional cortical topographies, however, cannot be derived using only anatomical features. We propose a new inter-subject registration algorithm that aligns intra-subject patterns of functional connectivity across subjects. We derive functional connectivity patterns by correlating fMRI BOLD time-series, measured during movie viewing, between spatially remote cortical regions. We validate our technique extensively on real fMRI experimental data and compare our method to two state-of-the-art inter-subject registration algorithms. By cross-validating our method on independent datasets, we show that the derived alignment generalizes well to other experimental paradigms.
authors.affiliation: Department of Electrical Engineering, Princeton University, Princeton, NJ, USA; Department of Biomedical Engineering, Columbia University, New York, NY, USA. Electronic address: bc2468@columbia.edu.
authors.forename: Bryan R
authors.initials: BR
authors.lastname: Conroy
authors.affiliation: Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Singer
authors.affiliation: Department of Psychological & Brain Sciences, Dartmouth College, Hanover, NH, USA.
authors.forename: J Swaroop
authors.initials: JS
authors.lastname: Guntupalli
authors.affiliation: Department of Electrical Engineering, Princeton University, Princeton, NJ, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Ramadge
authors.affiliation: Department of Psychological & Brain Sciences, Dartmouth College, Hanover, NH, USA; Center for Mind/Brain Sciences (CIMeC), Universitá degli studi di Trento, Rovereto, Italy.
authors.forename: James V
authors.initials: JV
authors.lastname: Haxby
mesh_terms: D000465:Algorithms; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology*; D055815:Young Adult
keywords: Functional connectivity; Inter-subject registration; Surface-based methods