title: Prediction of HIV drug resistance based on virologic, immunologic, clinical, and/or adherence criteria in the Stratall ANRS 12110/ESTHER trial in Cameroon.
abstract: Our study in Cameroonian rural district hospitals showed that the immunologic and clinical failure criteria had poor performance to identify human immunodeficiency virus drug resistance in a timely manner. Switching to second-line antiretroviral therapy after 2 consecutive viral loads ≥5000 copies/mL, as recommended by the World Health Organization, appeared to be the most appropriate strategy.
authors.affiliation: Institut de Recherche pour le Développement (IRD), University Montpellier 1, UMI 233 TransVIHMI, Montpellier, France. charlotte.boulle@ird.fr
authors.forename: Charlotte
authors.initials: C
authors.lastname: Boullé
authors.forename: Charles
authors.initials: C
authors.lastname: Kouanfack
authors.forename: Gabrièle
authors.initials: G
authors.lastname: Laborde-Balen
authors.forename: Avelin Fobang
authors.initials: AF
authors.lastname: Aghokeng
authors.forename: Sylvie
authors.initials: S
authors.lastname: Boyer
authors.forename: Maria Patrizia
authors.initials: MP
authors.lastname: Carrieri
authors.forename: Serge
authors.initials: S
authors.lastname: Kazé
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Mben
authors.forename: Marlise
authors.initials: M
authors.lastname: Dontsop
authors.forename: Bruno
authors.initials: B
authors.lastname: Spire
authors.forename: Martine
authors.initials: M
authors.lastname: Peeters
authors.forename: Eitel
authors.initials: E
authors.lastname: Mpoudi-Ngolé
authors.forename: Eric
authors.initials: E
authors.lastname: Delaporte
authors.forename: Christian
authors.initials: C
authors.lastname: Laurent
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D002163:Cameroon; D003661:Decision Support Techniques; D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology / Q000821:virology; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D012424:Rural Population; D019562:Viral Load; D016903:Drug Monitoring
chemical_list: D019380:Anti-HIV Agents
keywords: Africa; HIV; failure; resistance; switch