title: Synthesis and antitumor activity of substituted succinamides using a potato disc tumor induction assay.
abstract: In view of potential biological activities of some succinic acid derivatives, we synthesized some novel N-[4-(4-morpholinosulfonyl)-phenyl]-succinamides (6a, c; 7a, c) and N-[4-(benzylaminosulfonyl) phenyl]-succinamides (6b, d; 7b, d) derivatives as antitumor agents. The antitumor activity of compounds was studied using the potato disk bioassay technique. Vincristine at 0.25 mg/ml was employed as positive control and caused -67.24% inhibitions. Compound 7b at 1 mg/ml caused -80.50% tumor inhibitions with highest activity among compounds tested.
authors.affiliation: Biotechnology & Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; ; Pharmacy Faculty, Mashhad Univesrsity of Medical Sciences, Mashhad, Iran.
authors.forename: Farzin
authors.initials: F
authors.lastname: Hadizadeh
authors.forename: Alireza
authors.initials: A
authors.lastname: Moradi
authors.forename: Goli
authors.initials: G
authors.lastname: Naghibi
authors.forename: Mojgan
authors.initials: M
authors.lastname: Vojdani
authors.forename: Javad
authors.initials: J
authors.lastname: Behravan
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ramezani
keywords: antitumor; potato disc; succinamides