title: Acute myeloid leukaemia of donor cell origin developing 17 years after allogenic hematopoietic cell transplantation for acute promyelocytic leukaemia.
abstract: Donor cell leukaemia (DCL) is a rare complication of allogenic hematopoietic cell transplantation (HCT). We report the case of a female patient with acute promyelocytic leukaemia (APL), FAB type M3, who developed acute myeloid leukaemia (AML) type M5 of donor origin 17 years after allogenic bone marrow transplantation (BMT) from her HLA-matched sister. Morphology and immunophenotyping showed differences with the initial leukaemia, and short tandem repeat (STR) analysis confirmed donor-type haematopoiesis. Interphase fluorescence in situ hybridisation (FISH) showed an 11q23 deletion. Given that the latency period between transplant and development of leukaemia was the longest reported to date, we discuss the mechanisms underlying delayed leukaemia onset.
authors.affiliation: Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Granada, Spain;
authors.forename: Pilar
authors.initials: P
authors.lastname: Jiménez
authors.forename: J Carlos
authors.initials: JC
authors.lastname: Alvarez
authors.forename: Pilar
authors.initials: P
authors.lastname: Garrido
authors.forename: J Antonio
authors.initials: JA
authors.lastname: Lorente
authors.forename: Jorge
authors.initials: J
authors.lastname: Palacios
authors.forename: Francisco
authors.initials: F
authors.lastname: Ruiz-Cabello
keywords: FISH; MLL; STR; bone marrow transplantation; donor cell leukaemia