title: Variation of proteinuria in dogs with leishmaniasis treated with meglumine antimoniate and allopurinol: a retrospective study.
abstract: A retrospective study was performed using 53 client owned dogs with leishmaniasis to determine whether the degree of proteinuria, evaluated by the urine protein/creatinine ratio (UP/C), changes following treatment with meglumine antimoniate and allopurinol. Medical records of dogs with leishmaniasis in clinical stage C (according to the Canine Leishmaniasis Working Group staging system) and either proteinuric or borderline proteinuric (according to the International Renal Interest Society [IRIS] staging system) were reviewed. All dogs were treated with meglumine antimoniate and allopurinol for 4-8 wk. After treatment, UP/C, total protein, and total globulin significantly decreased and albumin and the albumin/globulin ratio (A/G) increased. After treatment, 7 of the 53 dogs (13.4%) became nonproteinuric following either a proteinuric or borderline proteinuric stage. Moreover, 12 of the 53 proteinuric dogs (22.6%) changed their stage to borderline proteinuric. The antileishmaniasis treatment with meglumine antimoniate in combination with allopurinol in dogs significantly reduced the degree of proteinuria in a short period of time. The results of the current study may be useful to the veterinary practitioner in the clinical management of canine leishmaniasis (CanL) in dogs with proteinuric chronic kidney disease.
authors.affiliation: Clinica Veterinaria Pirani, Reggio Emilia, Italy. pierantozzimarco@gmail.com
authors.forename: Marco
authors.initials: M
authors.lastname: Pierantozzi
authors.forename: Xavier
authors.initials: X
authors.lastname: Roura
authors.forename: Saverio
authors.initials: S
authors.lastname: Paltrinieri
authors.forename: Marco
authors.initials: M
authors.lastname: Poggi
authors.forename: Andrea
authors.initials: A
authors.lastname: Zatelli
mesh_terms: D000493:Allopurinol / Q000627:therapeutic use*; D000818:Animals; D003404:Creatinine / Q000652:urine; D004283:Dog Diseases / Q000188:drug therapy* / Q000652:urine; D004285:Dogs; D005260:Female; D007896:Leishmaniasis / Q000150:complications / Q000188:drug therapy / Q000652:urine / Q000662:veterinary*; D008297:Male; D008536:Meglumine / Q000627:therapeutic use*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011507:Proteinuria / Q000209:etiology / Q000662:veterinary*; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis
chemical_list: D009942:Organometallic Compounds; D012709:Serum Albumin; D000493:Allopurinol; D008536:Meglumine; D000077485:Meglumine Antimoniate; D003404:Creatinine