title: Peculiarities of amnesia development during memory reconsolidation impairment induced by isolated or combined treatment with neurotransmitter receptor antagonists.
abstract: The effects of serotonin and glutamate receptor antagonists on conditioned food aversion memory reconsolidation were studied in experiments on edible snails. Injections of NMDA and AMPA glutamate receptor antagonists to trained snails before the reminder were found to induce the development of "irreversible" amnesia: repeated training of these animals was not followed by memory formation. Administration of serotonin receptor antagonist before the reminder led to the development of "reversible" amnesia, repeated training was followed by memory formation. The combined administration of serotonin receptor antagonist with NMDA and AMPA receptor antagonists partially or completely abolished amnesia development. We hypothesized that both memory reconsolidation and amnesia induction require integration of specific patterns converging to neurons and involving certain types of neuro-transmitter receptors.
authors.affiliation: P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Russia. nikitin.vp@mail.ru
authors.forename: V P
authors.initials: VP
authors.lastname: Nikitin
authors.forename: S V
authors.initials: SV
authors.lastname: Solntseva
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D006372:Helix, Snails; D008568:Memory / Q000187:drug effects*; D023421:Models, Animal; D016202:N-Methylaspartate / Q000187:drug effects; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors*; D012702:Serotonin Antagonists / Q000494:pharmacology; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000494:pharmacology
chemical_list: D018691:Excitatory Amino Acid Antagonists; D017981:Receptors, Neurotransmitter; D012702:Serotonin Antagonists; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid