title: IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers.
abstract: Objectives. To investigate insulin-like growth factor I (IGF-1) levels in response to hyperbaric oxygen therapy (HBOT) for diabetic foot ulcers and to determine whether IGF-1 is a predictive indicator of wound healing in patients with diabetic foot ulcers. Design and Methods. We treated 48 consecutive patients with diabetic foot ulcers with HBOT. Alterations of IGF-1 levels in patients whose wound healed with HBOT were compared with those in patients who did not benefit from HBOT. Results. There was no significant difference in initial IGF-1 levels between the two groups (P = 0.399). The mean IGF-1 level increased with HBOT (P < 0.05). In the healed group, the mean IGF-1 increase and the final values were significantly higher (P < 0.05). In the nonhealed group, the mean IGF-1 increase was minus and the final values were not significantly different (P < 0.05). The increase in IGF-1 level with HBOT was significantly higher in the healed group (P < 0.001). Conclusions. IGF-1 increased significantly in the healed group. We believe that HBOT is effective in the treatment of diabetic foot ulcers, with an elevation of IGF-1. This alteration seems to be a predictive factor for wound healing in diabetic foot ulcers treated with HBOT.
authors.affiliation: Neoks Hyperbaric Oxygen Therapy Center, Bornova, 35560 Izmir, Turkey ; Underwater and Hyperbaric Medicine, Yeni Girne Bulvari No. 211, Karsiyaka, 35550 Izmir, Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Aydin
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kaya
authors.forename: Levent
authors.initials: L
authors.lastname: Karapinar
authors.forename: Mert
authors.initials: M
authors.lastname: Kumbaraci
authors.forename: Ahmet
authors.initials: A
authors.lastname: Imerci
authors.forename: Hasan
authors.initials: H
authors.lastname: Karapinar
authors.forename: Cengiz
authors.initials: C
authors.lastname: Karakuzu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Incesu