title: Embryonal tumor with abundant neuropil and true rosettes with melanotic (retinal) differentiation.
abstract: Embryonal tumor with abundant neuropil and true rosettes (ETANTR) is a rare variant of central nervous system primitive neuroectodermal tumor occurring exclusively in the pediatric population. We report a unique case of a 6-month male child presenting with a large intraventricular lesion. Histological examination revealed a tumor composed of primitive neuroectodermal cells in dense aggregates, interspersed by hypocellular areas containing small round cells widely dispersed in neuropil-like material. Few ependymal and occasional ependymoblastic rosettes were appreciated. Focal melanotic neuroepithelium recapitulating retinal differentiation was also seen. Documentation of such cases may expand the neuroectodermal differentiation spectrum of ETANTR.
authors.affiliation: 1Department of Pathology, GB Pant Hospital, New Delhi, India.
authors.forename: Kaushik
authors.initials: K
authors.lastname: Majumdar
authors.forename: Vineeta Vijay
authors.initials: VV
authors.lastname: Batra
authors.forename: Ila
authors.initials: I
authors.lastname: Tyagi
authors.forename: Ajay
authors.initials: A
authors.lastname: Sharma
mesh_terms: D002454:Cell Differentiation; D002551:Cerebral Ventricle Neoplasms / Q000378:metabolism / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D017600:Neuroectodermal Tumor, Melanotic / Q000378:metabolism / Q000473:pathology*; D018242:Neuroectodermal Tumors, Primitive / Q000378:metabolism / Q000473:pathology*; D016900:Neurofilament Proteins / Q000378:metabolism; D019581:Neuropil / Q000378:metabolism / Q000473:pathology; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D016900:Neurofilament Proteins; C569014:SYP protein, human; D016708:Synaptophysin