title: Highly stereoselective conjugate addition and α-alkynylation reaction with electron-deficient alkynes catalyzed by chiral scandium(III) complexes.
abstract: The highly Z-selective asymmetric conjugate addition of 3-substituted oxindoles to alkynyl carbonyl compounds has been developed by using scandium complexes of chiral N,N'-dioxides under mild conditions. The thermodynamically unstable Z-olefin derivatives were obtained in excellent yields and high enantiomeric and geometric control. The catalyst was also found to be effective in the asymmetric acetylenic substitution reaction of 3-substituted oxindoles, giving excellent enantioselectivities.
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Zuliang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Yao
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Cai
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng