title: Prognostic factors for outcomes after mechanical thrombectomy with solitaire stent.
abstract: OBJECTIVE
  Endovascular mechanical thrombectomy is emerging as a promising therapeutic approach for acute ischemic stroke. This study was aimed at identifying factors influencing outcomes after thrombectomy with a Solitaire stent device.
  
  
  METHODS
  Forty-five consecutive patients treated with thrombectomy using Solitaire FR were retrospectively included. Clinical, imaging and logistic variables were analyzed. A multivariate logistic regression analysis was used to identify variables influencing clinical outcome, based on discharge NIHSS score change and mRS at 3 months.
  
  
  RESULTS
  Patient mean age and initial NIHSS score was 58 years (range 24-88) and 17 (range 6-32), respectively. An MRI was performed for 80% of patients, showing severe DWI lesion for 28% of patients and associated FLAIR hyperintensity for 58% of patients. Mean time from symptom onset to recanalization was 299min for the 32 ACO and 473min for the 13 PCO. Angiographic efficacy (TICI 2b-3) was achieved for 93% of patients and good clinical outcomes at discharge and at 3 months (mRS≤2) were achieved for 49% and 58% of patients, respectively. Independent prognostic factors for predicting good clinical outcomes at discharge were a short time to recanalization and FLAIR negativity. At 3 months, they were a short time to recanalization and patient age. DWI lesion severity was an associated prognostic factor.
  
  
  CONCLUSIONS
  Two main prognostic factors for predicting a good clinical outcome after thrombectomy at 3 months were short time from symptom onset to recanalization and patient age.
authors.affiliation: CHU Rennes, Department of Neuroradiology, 2, rue Henri-Le-Guilloux, 35000 Rennes, France. Electronic address: helene.raoult@chu-rennes.fr.
authors.forename: Hélène
authors.initials: H
authors.lastname: Raoult
authors.forename: François
authors.initials: F
authors.lastname: Eugène
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Ferré
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Gentric
authors.forename: Thomas
authors.initials: T
authors.lastname: Ronzière
authors.forename: Aymeric
authors.initials: A
authors.lastname: Stamm
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Gauvrit
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery*; D015984:Causality; D015897:Comorbidity; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000706:statistics & numerical data*; D008297:Male; D061185:Mechanical Thrombolysis / Q000401:mortality*; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D017678:Sex Distribution; D015607:Stents / Q000706:statistics & numerical data*; D020521:Stroke / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery*; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
keywords: ACO; ASPECT; Alberta stroke program early CT; DWI; IV; NIHSS; National Institutes of Health Stroke Scale; PCO; Prognostic factors; ROC curves; Receiver Operating Characteristic curves; Stroke; TICI; Thrombectomy; anterior circulation occlusions; diffusion-weighted imaging; intravenous; mRS; modified Rankin Scale; posterior circulation occlusions; thrombolysis in cerebral infarction score