title: Frovatriptan plus dexketoprofen in the treatment of menstrually related migraine: an open study.
abstract: At least 50 % of female migraineurs experience migraine associated with the perimenstrual period, even though they may also suffer from attacks at other times of the cycle (menstrually related migraine, MRM). MRM attacks tend to be longer and more intense than those arising in other phases of the menstrual cycle, and are often aggravated by more pronounced vegetative phenomena. In this open preliminary trial, we tested the efficacy of associating frovatriptan and dexketoprofen for the treatment of an acute attack of MRM, diagnosed according to the criteria of the International Headache Society, in 24 patients between 19 and 45 years of age (mean 31.33 ± 7.33). Twenty-one of them completed the study. Pain relief was achieved by 76 % of patients at 2 h and by 86 % at 4 h. A pain-free state was achieved by 48 % at 2 h and by 62 % at 4 h from taking the product. A pain-free state at 24 h was present in 76 % of MRM sufferers, 33 % of whom showed a sustained pain-free state at 24 h. A rescue medication was needed by eight patients. While decidedly encouraging, the data of this study obviously need confirmation with double blind studies involving a greater number of patients.
authors.affiliation: Women's Headache Center, Department of Gynecology and Obstetrics, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy. gb.allais@tiscali.it
authors.forename: Gianni
authors.initials: G
authors.lastname: Allais
authors.forename: Sara
authors.initials: S
authors.lastname: Rolando
authors.forename: Paola
authors.initials: P
authors.lastname: Schiapparelli
authors.forename: Gisella
authors.initials: G
authors.lastname: Airola
authors.forename: Paola
authors.initials: P
authors.lastname: Borgogno
authors.forename: Ornella
authors.initials: O
authors.lastname: Mana
authors.forename: Chiara
authors.initials: C
authors.lastname: Benedetto
mesh_terms: D000328:Adult; D002227:Carbazoles / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D008597:Menstrual Cycle; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy* / Q000209:etiology; D014325:Tromethamine / Q000008:administration & dosage* / Q000009:adverse effects; D014363:Tryptamines / Q000008:administration & dosage* / Q000009:adverse effects; D055815:Young Adult
chemical_list: D002227:Carbazoles; D014363:Tryptamines; D014325:Tromethamine; D007660:Ketoprofen; C108128:frovatriptan; C118296:dexketoprofen trometamol