title: Dual surface-functionalized Janus nanocomposites of polystyrene/Fe₃O₄@SiO₂ for simultaneous tumor cell targeting and stimulus-induced drug release.
abstract: Folic acid (FA) and doxorubicin (DOX) are coupled separately onto Fe3 O4 @SiO2 and polystyrene surfaces of a unique polystyrene/Fe3 O4 @SiO2 Janus structure. This super-paramagnetic, dual-functionalized Janus nanocomposite enables effective tumor cell targeting and internalization via the folate receptor, and induces significant cancer cell death by controlled, stimulus-induced drug release under acidic conditions in endosomal compartments.
authors.affiliation: Materials Science and Engineering Program, University of Cincinnati, Cincinnati, OH 45221, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Giovanni M
authors.initials: GM
authors.lastname: Pauletti
authors.forename: Juntao
authors.initials: J
authors.lastname: Wang
authors.forename: Jiaming
authors.initials: J
authors.lastname: Zhang
authors.forename: Rodney C
authors.initials: RC
authors.lastname: Ewing
authors.forename: Yilong
authors.initials: Y
authors.lastname: Wang
authors.forename: Donglu
authors.initials: D
authors.lastname: Shi
mesh_terms: D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D011137:Polystyrenes; D012822:Silicon Dioxide; D004317:Doxorubicin; D052203:Ferrosoferric Oxide
keywords: Janus nanocomposites; drug delivery; dual-functionality; targeting