title: [Familial adenomatous polyposis].
abstract: Familial adenomatous polyposis (FAP) is an autosomally dominant disease characterized by early development of up to thousands of colorectal adenomas and colorectal carcinoma in untreated patients. Extra-colonic manifestations include duodenal adenomatosis and desmoid development. Due to identification of gene carriers by DNA analysis or endoscopy the prognosis is good after early colectomy, but life-long surveillance of the rectum and the duodenum is necessary. The Danish Polyposis Register coordinates prophylactic examination and treatment in the families, and serves as basis for research.
authors.affiliation: Polyposeregistret, Gastroenheden, Hvidovre Hospital, Kettegård Allé 30, 2650 Hvidovre, Denmark. sbulow@dadlnet.dk
authors.forename: Steffen
authors.initials: S
authors.lastname: Bülow
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D003082:Colectomy; D003937:Diagnosis, Differential; D006801:Humans; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D012042:Registries