title: Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican inter-institutional group for the identification of the causes of childhood leukaemia.
abstract: BACKGROUND
  Allergies have been described as protective factors against the development of childhood acute leukaemia (AL). Our objective was to investigate the associations between allergy history and the development of AL and acute lymphoblastic leukaemia (ALL) in children with Down syndrome (DS).
  
  
  METHODS
  A case-control study was performed in Mexico City. The cases (n=97) were diagnosed at nine public hospitals, and the controls (n=222) were recruited at institutions for children with DS. Odds ratios (OR) were calculated.
  
  
  RESULTS
  Asthma was positively associated with AL development (OR=4.18; 95% confidence interval (CI): 1.47-11.87), whereas skin allergies were negatively associated (OR=0.42; 95% CI: 0.20-0.91).
  
  
  CONCLUSIONS
  Our findings suggest that allergies and AL in children with DS share biological and immune mechanisms. To our knowledge, this is the first study reporting associations between allergies and AL in children with DS.
authors.affiliation: Unidad de Investigación Médica en Epidemiologia Clínica, Hospital de Pediatría, Centro Médico Nacional (CMN) Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauhtémoc 330, Delegación Cuauhtémoc, México D.F. 06720, México. juan.mejiaa@imss.gob.mx
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authors.initials: JC
authors.lastname: Núñez-Enríquez
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authors.lastname: Fajardo-Gutiérrez
authors.forename: E P
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authors.lastname: Buchán-Durán
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authors.lastname: Bernáldez-Ríos
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authors.lastname: Medina-Sansón
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authors.lastname: Jiménez-Hernández
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authors.lastname: Amador-Sanchez
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authors.initials: JG
authors.lastname: Peñaloza-Gonzalez
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authors.lastname: Paredes-Aguilera
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authors.initials: FJ
authors.lastname: Alvarez-Rodriguez
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authors.lastname: Bolea-Murga
authors.forename: J
authors.initials: J
authors.lastname: de Diego Flores-Chapa
authors.forename: J
authors.initials: J
authors.lastname: Flores-Lujano
authors.forename: V C
authors.initials: VC
authors.lastname: Bekker-Mendez
authors.forename: R
authors.initials: R
authors.lastname: Rivera-Luna
authors.forename: M
authors.initials: M
authors.lastname: Del Carmen Rodriguez-Zepeda
authors.forename: A
authors.initials: A
authors.lastname: Rangel-López
authors.forename: E M
authors.initials: EM
authors.lastname: Dorantes-Acosta
authors.forename: N
authors.initials: N
authors.lastname: Núñez-Villegas
authors.forename: M M
authors.initials: MM
authors.lastname: Velazquez-Aviña
authors.forename: J R
authors.initials: JR
authors.lastname: Torres-Nava
authors.forename: N C
authors.initials: NC
authors.lastname: Reyes-Zepeda
authors.forename: R
authors.initials: R
authors.lastname: Cárdenas-Cardos
authors.forename: L V
authors.initials: LV
authors.lastname: Flores-Villegas
authors.forename: A
authors.initials: A
authors.lastname: Martinez-Avalos
authors.forename: F
authors.initials: F
authors.lastname: Salamanca-Gómez
authors.forename: C
authors.initials: C
authors.lastname: Gorodezky
authors.forename: J
authors.initials: J
authors.lastname: Arellano-Galindo
authors.forename: J M
authors.initials: JM
authors.lastname: Mejía-Aranguré
mesh_terms: D016022:Case-Control Studies; D002648:Child; D004314:Down Syndrome / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D008800:Mexico / Q000453:epidemiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology*