title: Adverse metabolic risk profiles in Greenlandic Inuit children compared to Danish children.
abstract: OBJECTIVE
  During recent decades, the prevalence of metabolic morbidity has increased rapidly in adult Greenlandic Inuit. To what extent this is also reflected in the juvenile Inuit population is unknown. The objective was, therefore, in the comparison with Danish children, to evaluate metabolic profiles in Greenlandic Inuit children from the capital in the southern and from the northern most villages
  
  
  METHODS
  187 Inuit and 132 Danish children were examined with anthropometrics, pubertal staging, fasting blood samples, and a maximal aerobic test.
  
  
  RESULTS
  Both Inuit children living in Nuuk and the northern villages had significantly higher glucose, total cholesterol, apolipoprotein A1 levels, and diastolic blood pressure compared with Danish children after adjustment for differences in adiposity and aerobic fitness levels. The Inuit children living in Nuuk had significantly higher BMI, body fat %, HbA1 c, and significantly lower aerobic fitness and ApoA1 levels than northern living Inuit children.
  
  
  CONCLUSIONS
  Greenlandic Inuit children had adverse metabolic health profile compared to the Danish children, the differences where more pronounced in Inuit children living in Nuuk. The tendencies toward higher prevalence of diabetes and metabolic morbidity in the adult Greenlandic Inuit population may also be present in the Inuit children population.
authors.affiliation: Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. thormunchandersen@gmail.com
authors.forename: T
authors.initials: T
authors.lastname: Munch-Andersen
authors.forename: K
authors.initials: K
authors.lastname: Sorensen
authors.forename: L B
authors.initials: LB
authors.lastname: Andersen
authors.forename: N J
authors.initials: NJ
authors.lastname: Aachmann-Andersen
authors.forename: L
authors.initials: L
authors.lastname: Aksglaede
authors.forename: A
authors.initials: A
authors.lastname: Juul
authors.forename: J W
authors.initials: JW
authors.lastname: Helge
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D050154:Adiposity / Q000502:physiology; D000293:Adolescent; D016632:Apolipoprotein A-I / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001823:Body Composition; D002648:Child; D002784:Cholesterol / Q000097:blood; D003718:Denmark / Q000453:epidemiology; D005215:Fasting; D005260:Female; D006116:Greenland / Q000453:epidemiology; D006801:Humans; D004930:Inuit; D016014:Linear Models; D008297:Male; D055442:Metabolome; D009765:Obesity / Q000097:blood / Q000208:ethnology*; D050177:Overweight / Q000097:blood / Q000208:ethnology*; D015995:Prevalence; D012307:Risk Factors; D044465:White People
chemical_list: D016632:Apolipoprotein A-I; D001786:Blood Glucose; D002784:Cholesterol