title: Effect of intracerebral transplantation of mesenchymal stem cells on pial microcirculation in rats.
abstract: We studied the effect of intracerebral transplantation of bone marrow mesenchymal stem cells on microcirculation (density of microvascular network and reactivity of arterioles) in the pia mater of 2-3-month-old rats. It was found that after transplantation of mesenchymal stem cells, the density of pial microcirculatory network in the contralateral hemisphere significantly increased (by 1.7 times; p<0.05) in comparison with both intact animals and controls. The number of arterioles in the studied area increased most markedly (by ≈2.5 times; p<0.05) in comparison with other groups. Intracerebral transplantation of mesenchymal stem cells or conditioned culture medium (α-MEM) had no effect on reactivity of pial arterioles.
authors.affiliation: Laboratory of Physiology of Circulation, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, Russia. sib@kolt.infran.ru
authors.forename: I B
authors.initials: IB
authors.lastname: Sokolova
authors.forename: I V
authors.initials: IV
authors.lastname: Sergeev
authors.forename: A A
authors.initials: AA
authors.lastname: Bilibina
authors.forename: S V
authors.initials: SV
authors.lastname: Anisimov
authors.forename: D P
authors.initials: DP
authors.lastname: Dvoretsky
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells; D008833:Microcirculation; D055806:Microvessels / Q000166:cytology*; D018919:Neovascularization, Physiologic; D010841:Pia Mater / Q000098:blood supply*; D051381:Rats