title: [Relationship between degree of white matter damage and EEG changes in premature infants early after birth].
abstract: OBJECTIVE
  To study the relationship between the degree of white matter damage and changes in brain function in premature infants early after birth according to amplitude-integrated electroencephalogram (aEEG) and raw EEG (with burst-suppression patterns).
  
  
  METHODS
  Thirty-eight premature infants of less than 32 weeks' gestational age and with white matter damage, including 20 cases of mild white matter damage and 18 cases of severe white matter damage, were included in the study. Forty-two premature infants without white matter damage were selected as a control group. After birth, they were examined using aEEG and brain ultrasound once a week until four weeks after birth or a corrected gestational age of 32 weeks. The white matter damage and control groups were compared in terms of aEEG patterns and amplitudes and burst suppression ratio (BSR) on EEG.
  
  
  RESULTS
  The white matter damage and control groups had highly discontinuous patterns and had no complete sleep cycles. The lower amplitude was significantly smaller in the severe white matter damage subgroup than in the mild white matter damage subgroup and control group. There was alternating burst-suppression activity on the raw EEG in the white matter damage and control groups; and the severe white matter damage subgroup had a significantly longer suppression time and a significantly higher BSR on EEG compared with the mild white matter damage subgroup and control group.
  
  
  CONCLUSIONS
  Brain function monitoring should be performed in premature infants with white matter damage early after birth so as to detect cases of severe white matter damage in time.
authors.affiliation: Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China. liuyunfeng96@163.com
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Liu
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Tong
authors.forename: Cong-Le
authors.initials: CL
authors.lastname: Zhou
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Zhang
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Piao
authors.forename: Zai-Ling
authors.initials: ZL
authors.lastname: Li
mesh_terms: D001921:Brain / Q000473:pathology*; D004569:Electroencephalography; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007969:Leukomalacia, Periventricular / Q000503:physiopathology*