title: Perspectives on treatment of metastatic castration-resistant prostate cancer.
abstract: The arrival of several new agents--cabazitaxel, abiraterone acetate, enzalutamide, and radium-223--is changing the treatment options and management of patients with metastatic castration-resistant prostate cancer (mCRPC). Many other novel agents are also being investigated. As new drugs become approved, new treatment strategies and markers to best select which patients will best respond to which drug are needed. This review article is a summary of a European Treatment Practices Meeting, which was convened to discuss these latest data on novel agents and current treatment strategies in the mCRPC setting.
authors.affiliation: Department of Urology and Urologic Oncology, Hannover Medical School, Hannover, Germany. merseburger.axel@mh-hannover.de
authors.forename: Axel S
authors.initials: AS
authors.lastname: Merseburger
authors.forename: Joaquim
authors.initials: J
authors.lastname: Bellmunt
authors.forename: Cheryl
authors.initials: C
authors.lastname: Jenkins
authors.forename: Chris
authors.initials: C
authors.lastname: Parker
authors.forename: John M
authors.initials: JM
authors.lastname: Fitzpatrick
mesh_terms: D000069501:Abiraterone Acetate; D000726:Androgen Antagonists / Q000008:administration & dosage*; D000730:Androstadienes / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001549:Benzamides; D002986:Clinical Trials as Topic; D000077143:Docetaxel; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis / Q000188:drug therapy* / Q000473:pathology; D009570:Nitriles; D010669:Phenylthiohydantoin / Q000008:administration & dosage / Q000031:analogs & derivatives; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy* / Q000473:pathology; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D000726:Androgen Antagonists; D000730:Androstadienes; D001549:Benzamides; D009570:Nitriles; D043823:Taxoids; D000077143:Docetaxel; D010669:Phenylthiohydantoin; C552428:cabazitaxel; C540278:enzalutamide; D000069501:Abiraterone Acetate
keywords: Abiraterone acetate; Cabazitaxel; Docetaxel; Enzalutamide; Metastatic castration-resistant; Prostate cancer; Treatment