title: Engineering and Applications of DNA-Grafting Polymer Materials.
abstract: The emergence of hybrid materials combining biomacromolecules and organic polymers has received broad attention based on their potential applications in chemical, biological and materials sciences. Among different coupling strategies, the grafting of oligonucleotides to organic polymers as side chains by covalent bonds provides a novel platform whereby the properties of both oligonucleotides and polymer backbone are integrated, manipulated and optimized for various applications. In this review, we give the perspective on this specific type of DNA polymer hybrid materials , using selected examples with emphasis on bioanalysis, biomedicine and stimuli-responsive materials. It is expected the success of DNA-grafting polymers will not only impact the frabication of novel bimolecule incorporated materials, but also will influence how the properties of synthetic materials are tailored using different functional groups.
authors.affiliation: Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute University of Florida, Gainesville, Florida 32611-7200, United States.
authors.forename: Lu
authors.initials: L
authors.lastname: Peng
authors.forename: Cuichen
authors.initials: C
authors.lastname: Wu
authors.forename: Mingxu
authors.initials: M
authors.lastname: You
authors.forename: Da
authors.initials: D
authors.lastname: Han
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Ting
authors.initials: T
authors.lastname: Fu
authors.forename: Mao
authors.initials: M
authors.lastname: Ye
authors.forename: Weihong
authors.initials: W
authors.lastname: Tan