title: Pregnancy-induced hypertension is associated with maternal history and a risk of cardiovascular disease in later life: Japanese cross-sectional study.
abstract: OBJECTIVE
  To clarify the associations between pregnancy-induced hypertension (PIH) with heritability of PIH from mother to daughter and the risk of cardiovascular disease in later life in Japanese women.
  
  
  METHODS
  The Japan Nurses' Health Study (JNHS) is a cohort study of Japanese women's health. Data from the JNHS baseline survey between 2001 and 2007 were used to conduct a cross-sectional analysis. Of the 49,927 respondents in the baseline survey, 10,456 parous women who were ≥45 years old at baseline were included in the analysis.
  
  
  METHODS
  The age-adjusted odds ratio (OR) of PIH in women whose mother had a history of PIH, and the age-adjusted OR of PIH in participants for hypertension, hypercholesterolemia and diabetes mellitus (DM).
  
  
  RESULTS
  The age-adjusted OR of PIH was 2.72 (95% confidence interval [CI]: 2.14-3.46) in women whose mother had a history of PIH compared with those whose mother did not have PIH. PIH was a risk factor for hypertension (age adjusted OR: 2.85, 95% CI: 2.45-3.11), hypercholesterolemia (age-adjusted OR: 1.49, 95% CI: 1.29-1.72) and DM (age-adjusted OR: 1.53, 95% CI: 1.11-2.11), as determined by logistic regression analysis.
  
  
  CONCLUSIONS
  In Japanese women, the risk of PIH is approximately 2.7-fold greater in those whose mothers also had PIH compared with those whose mothers did not. PIH is a risk factor for hypertension, hypercholesterolemia, and diabetes mellitus in later life.
authors.affiliation: Department of Obstetrics and Gynecology, Niigata City General Hospital, Niigata, Japan. takumi@hosp.niigata.niigata.jp
authors.forename: Takumi
authors.initials: T
authors.lastname: Kurabayashi
authors.forename: Hideki
authors.initials: H
authors.lastname: Mizunuma
authors.forename: Toshiro
authors.initials: T
authors.lastname: Kubota
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kiyohara
authors.forename: Kazue
authors.initials: K
authors.lastname: Nagai
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Hayashi
mesh_terms: D044466:Asian People; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000209:etiology*; D005260:Female; D006306:Health Surveys; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology*; D006973:Hypertension / Q000209:etiology*; D046110:Hypertension, Pregnancy-Induced / Q000209:etiology*; D007564:Japan; D016015:Logistic Models; D008875:Middle Aged; D009035:Mothers; D016017:Odds Ratio; D011247:Pregnancy; D012307:Risk Factors