title: [An efficacy comparison of betahistin, trimetazidine and ginkgo biloba extract in patients with tinnitus].
abstract: OBJECTIVE
  This study aims to investigate the efficacy of trimetazidine, betahistine and ginkgo biloba extract in the treatment of tinnitus.
  
  
  METHODS
  Complete clinical data of 90 patients (48 males, 42 females; mean age 52.3±15.1 years; range 20 to 61 years) who received betahistine, trimetazidine and ginkgo biloba extract for three months were retrospectively analyzed. The patients were divided into three groups including 30 in each group according to treatments received. Pre-treatment and post-treatment scores of tinnitus disability questionnaire were compared statistically.
  
  
  RESULTS
  There was no statistically significant difference between pre-treatment scores of tinnitus disability questionnaire among all three groups (p>0.05), while there was a statistically significant difference among the groups following treatment (p=0.019, p<0.05). After a-three-month treatment, a decrease of 19.7±15.5 units in trimetazidine group, 12.2±12.7 units in betahistine group, and 3.80±5.9 units in ginkgo biloba extract group were found to be statistically significant, compared to the mean pretreatment tinnitus disability questionnaire scores (p=0.002, p<0.01).
  
  
  CONCLUSIONS
  Our study results suggest that trimetazidine, betahistin and ginkgo biloba extract reduce tinnitus symptoms. However, symptomatic relief can be mostly achieved with trimetazidine treatment.
authors.affiliation: Department of Otolaryngology, Medipol University School of Medicine, İstanbul, Turkey. israfil.orhan@mynet.com
authors.forename: Israfil
authors.initials: I
authors.lastname: Orhan
authors.forename: Salih
authors.initials: S
authors.lastname: Aydın
authors.forename: Gökhan
authors.initials: G
authors.lastname: Altın
authors.forename: Fahrettin
authors.initials: F
authors.lastname: Yılmaz
mesh_terms: D000328:Adult; D001621:Betahistine / Q000627:therapeutic use*; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*; D014012:Tinnitus / Q000188:drug therapy* / Q000453:epidemiology; D014292:Trimetazidine / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D010936:Plant Extracts; D014292:Trimetazidine; D001621:Betahistine