title: Influenza evolution navigates stability valleys.
abstract: By reconstructing how an influenza protein collected in 1968 might have evolved into one collected in 2007, researchers have obtained new insights into the interactions between genetic mutations.
authors.affiliation: is at the Department of Ecology and Evolutionary Biology , University of Michigan , Ann Arbor , United States rorick@umich.edu.
authors.forename: Mary M
authors.initials: MM
authors.lastname: Rorick
authors.forename: Mercedes
authors.initials: M
authors.lastname: Pascual
mesh_terms: D004843:Epistasis, Genetic; D019143:Evolution, Molecular; D006801:Humans; D009975:Orthomyxoviridae / Q000378:metabolism*; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D014764:Viral Proteins
keywords: Viruses; epistasis; influenza; protein evolution; protein instability