title: Activity of succinate dehydrogenase in the neocortex and hippocampus of Mongolian gerbils with ischemic and reperfusion brain injury.
abstract: We analyzed changes in activity of SDH, one of the most important enzymes of the Krebs cycle, in the cytoplasm of hippocampal and cortical neurons of Mongolian gerbils (Meriones unguiculatus) at the early and delayed reperfusion period after global brain ischemia. The data indicate that SDH activity in pyramidal neurons of various hippocampal areas and in neurons of II, III and V layers of cerebral cortex after 7-min forebrain ischemia depends on both the localization of these neurons and duration of the postischemic reperfusion. SDH activity in neurons significantly increased on days 2 and 7 after reperfusion.
authors.affiliation: I. P. Pavlov St. Petersburg State Medical University, St. Petersburg, Russia. ShcherbakNS@yandex.ru
authors.forename: N S
authors.initials: NS
authors.lastname: Shcherbak
authors.forename: M M
authors.initials: MM
authors.lastname: Galagudza
authors.forename: D A
authors.initials: DA
authors.lastname: Ovchinnikov
authors.forename: A N
authors.initials: AN
authors.lastname: Kuzmenkov
authors.forename: G Yu
authors.initials: GY
authors.lastname: Yukina
authors.forename: E R
authors.initials: ER
authors.lastname: Barantsevich
authors.forename: V V
authors.initials: VV
authors.lastname: Tomson
authors.forename: E V
authors.initials: EV
authors.lastname: Shlyakhto
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D001930:Brain Injuries / Q000201:enzymology; D002545:Brain Ischemia / Q000201:enzymology*; D005849:Gerbillinae; D006624:Hippocampus / Q000201:enzymology*; D008297:Male; D019579:Neocortex / Q000201:enzymology*; D017966:Pyramidal Cells / Q000201:enzymology*; D015427:Reperfusion Injury / Q000201:enzymology*; D013385:Succinate Dehydrogenase / Q000378:metabolism*
chemical_list: D013385:Succinate Dehydrogenase