title: [Research progress in aromatic prenyltransferases originated from microorganisms].
abstract: The prenylation of aromatic compounds plays an important role in the natural product research because it not only gives rise to an astounding diversity of primary and secondary metabolites in plants, fungi and bacteria but also enhances the bioactivities and bioavailabilities of these compounds. However, further investigation of prenylated aromatic compounds is frequently hindered due to their low content in nature and difficulties in chemical synthesis. Cloning aromatic prenyltransferase genes followed by heterologous expression would be attractive tools for the chemoenzymatic synthesis of bioactive molecules. This review summarizes the classifications, structural investigations, enzymatic catalysis and other progress in aromatic prenyltransferases originated from microorganisms.
authors.affiliation: State Key Laboratory ofBioactive Substance and Function of Natural Medicines, Institute ofMateria Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.forename: Ri-Dao
authors.initials: RD
authors.lastname: Chen
authors.forename: Dan
authors.initials: D
authors.lastname: Xie
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Li
authors.forename: Rui-Shan
authors.initials: RS
authors.lastname: Wang
authors.forename: Jun-Gui
authors.initials: JG
authors.lastname: Dai
mesh_terms: D001419:Bacteria / Q000201:enzymology*; D004122:Dimethylallyltranstransferase / Q000096:biosynthesis* / Q000737:chemistry / Q000145:classification; D005658:Fungi / Q000201:enzymology*; D015394:Molecular Structure; D013379:Substrate Specificity; D058615:Synthetic Biology
chemical_list: C509554:4-hydroxybenzoic acid oligoprenyltransferase, E coli; D004122:Dimethylallyltranstransferase