title: The effects of 15 Hz trans-spinal magnetic stimulation on locomotor control in mice with chronic contusive spinal cord injury.
abstract: The effects of repetitive trans-spinal magnetic stimulation (rTSMS), combined with acrobatic exercise on functional locomotor recovery in chronic spinal-contused mice were tested. The exposure to magnetic stimulation was initiated 3 weeks after injury, when the animals entered chronic stage. The rTSMS was applied for a total of 4 weeks over a 9-week duration trial. Seventeen mice with the spinal cord contusion injured at level T13 were separated into two groups. While one group consisting of 10 animals was exposed to rTSMS (15 Hz), the other seven animals served as controls. Functional recovery measured with Basso mouse scale and horizontal ladder scale showed significantly better functional recovery in rTSMS-treated animals. The progress in recovery continued even after cessation of magnetic stimulation. In vitro experiments revealed that the release of glutamate analog, radioactive D-aspartate from the segments of the spinal cord exposed to rTSMS was significantly elevated. In conclusion, the exposure to rTSMS, applied to injured spinal cord during chronic post-surgery stage remarkably improves the functional recovery. This recovery may be correlated by magnetically induced elevation in the release of major excitatory neurotransmitter, glutamate from injured tissue.
authors.affiliation: Department of Physical Therapy, the College of Staten Island, Staten Island, NY 10314, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Leydeker
authors.forename: Stanley
authors.initials: S
authors.lastname: Delva
authors.forename: Igor
authors.initials: I
authors.lastname: Tserlyuk
authors.forename: Joseph
authors.initials: J
authors.lastname: Yau
authors.forename: Mekhael
authors.initials: M
authors.lastname: Wagdy
authors.forename: Ahmed
authors.initials: A
authors.lastname: Hawash
authors.forename: Salim
authors.initials: S
authors.lastname: Bendaoud
authors.forename: Salah
authors.initials: S
authors.lastname: Mohamed
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wieraszko
authors.forename: Zaghloul
authors.initials: Z
authors.lastname: Ahmed
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D002908:Chronic Disease; D026603:D-Aspartic Acid / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D008124:Locomotion; D055909:Magnetic Field Therapy; D008297:Male; D051379:Mice; D020127:Recovery of Function; D013116:Spinal Cord / Q000378:metabolism / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000503:physiopathology* / Q000628:therapy*; D013131:Spine
chemical_list: D018698:Glutamic Acid; D026603:D-Aspartic Acid