title: Surface hydrophilic modification of polyethersulfone membranes by surface-initiated ATRP with enhanced blood compatibility.
abstract: Surface-initiated atom transfer radical polymerization (SI-ATRP) was used to tailor the functionality of polyethersulfone (PES) membranes. A two-step method including nitration reaction and amination reaction was used to synthesize aminated polyethersulfone (PES-NH2) for the preparation of PES/PES-NH2 membranes. Covalently tethered hydrophilic polymer brushes of poly(N-vinylpyrrolidone) (PVP) were prepared via SI-ATRP at low temperature in an aqueous solvent. Attenuated total reflection-Fourier transform infrared (ATR-FTIR), scanning electron microscopy coupled with energy dispersive spectroscopy (SEM-EDS), and water contact angle were used to characterize the modified membranes surfaces. The PVP-grafted PES membranes showed lower protein adsorption and suppressed platelet adhesion compared with the pristine PES membrane. Moreover, the activated partial thromboplastin time (APTT) for the PVP-grafted PES membranes was increased. These results indicated that the surface hydrophilic modification by grafting PVP brushes provided practical application for the PES membranes with good blood compatibility.
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xiang
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Yue
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Su
authors.initials: S
authors.lastname: Liang
authors.forename: Shu-Dong
authors.initials: SD
authors.lastname: Sun
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Zhao
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects; D058105:Polymerization; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D011145:Polyvinyls / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013450:Sulfones / Q000737:chemistry / Q000494:pharmacology*; D013499:Surface Properties; D014914:Whole Blood Coagulation Time
chemical_list: D011108:Polymers; D011145:Polyvinyls; D011759:Pyrrolidines; D013450:Sulfones; C505150:poly(N-vinylpyrrolidine); C022840:polyether sulfone