title: Anaplastic lymphoma kinase (ALK1) immunohistochemistry in diagnostic dermatopathology; an update.
abstract: The use of anaplastic lymphoma kinase antibodies (ALK1) as a diagnostic aid has expanded since becoming a routinely available immunohistochemical stain. Because the skin may be the site of a wide variety of hematolymphoid and fibroblastic proliferations, dermatopathologists commonly use ALK1 as part of a broader staining panel in diagnosing soft tissue and cutaneous hematolymphoid neoplasms. Furthermore, new entities and differential diagnostic contexts are emerging, which broaden the utility of ALK1 immunohistochemistry. We review the expanding role of ALK1 immunohistochemistry in contemporary dermatopathology.
authors.affiliation: Pathology Section, Eastern Dermatology and Pathology, Greenville, NC, USA. papalas@easternderm.com
authors.forename: John A
authors.initials: JA
authors.lastname: Papalas
authors.forename: Evan
authors.initials: E
authors.lastname: Kulbacki
authors.forename: Endi
authors.initials: E
authors.lastname: Wang
mesh_terms: D030301:Activin Receptors, Type II / Q000032:analysis* / Q000235:genetics; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001706:Biopsy; D003880:Dermatology / Q000379:methods*; D006801:Humans; D007150:Immunohistochemistry; D010336:Pathology / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D012867:Skin / Q000201:enzymology* / Q000473:pathology; D012878:Skin Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C425364:ACVRL1 protein, human; D030301:Activin Receptors, Type II