title: The great repression: chromatin and cryptic transcription.
abstract: The eukaryotic chromatin structure is essential in correctly defining transcription units. Impairing this structure can activate cryptic promoters, and lead to the accumulation of aberrant RNA transcripts. Here we discuss critical pathways that are responsible for the repression of cryptic transcription and the maintenance of genome integrity.
authors.affiliation: Biochemistry Center (BZH); Heidelberg University; Heidelberg, Germany.
authors.forename: Bianca P
authors.initials: BP
authors.lastname: Hennig
authors.forename: Tamás
authors.initials: T
authors.lastname: Fischer
mesh_terms: D002843:Chromatin / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D009707:Nucleosomes / Q000378:metabolism; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism; D022661:RNA, Untranslated / Q000378:metabolism; D014158:Transcription, Genetic; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D002843:Chromatin; D005656:Fungal Proteins; D006657:Histones; D009707:Nucleosomes; D022661:RNA, Untranslated; D012319:RNA Polymerase II; D006655:Histone Deacetylases
keywords: chromatin; cryptic promoters; cryptic transcription; histone modifications; ncRNA; nucleosomes