title: Response of human dental pulp capped with biodentine and mineral trioxide aggregate.
abstract: BACKGROUND
  Biodentine is a new bioactive cement that is similar to the widely used mineral trioxide aggregate (MTA). It has dentin-like mechanical properties, which may be considered a suitable material for clinical indications of dentin-pulp complex regeneration such as direct pulp capping. The purpose of the present study was to compare the response of the pulp-dentin complex in human teeth after direct capping with this new tricalcium silicate-based cement with that of MTA.
  
  
  METHODS
  Pulps in 28 caries-free maxillary and mandibular permanent intact human molars scheduled for extraction for orthodontic reasons were mechanically exposed and assigned to 1 of 2 experimental groups, Biodentine or MTA, and 1 control group. Assay of periapical response and clinical examination were performed. After 6 weeks, the teeth were extracted, stained with hematoxylin-eosin, and categorized by using a histologic scoring system.
  
  
  RESULTS
  The majority of specimens showed complete dentinal bridge formation and an absence of inflammatory pulp response. Layers of well-arranged odontoblast and odontoblast-like cells were found to form tubular dentin under the osteodentin. Statistical analysis showed no significant differences between the Biodentine and MTA experimental groups during the observation period.
  
  
  CONCLUSIONS
  Within the limitations of this study, Biodentine had a similar efficacy in the clinical setting and may be considered an interesting alternative to MTA in pulp-capping treatment during vital pulp therapy.
authors.affiliation: Department of Conservative Dentistry, Pomeranian Medical University, Szczecin, Poland. nowicka6@gmail.com
authors.forename: Alicja
authors.initials: A
authors.lastname: Nowicka
authors.forename: Mariusz
authors.initials: M
authors.lastname: Lipski
authors.forename: Mirosław
authors.initials: M
authors.lastname: Parafiniuk
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Sporniak-Tutak
authors.forename: Damian
authors.initials: D
authors.lastname: Lichota
authors.forename: Anita
authors.initials: A
authors.lastname: Kosierkiewicz
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kaczmarek
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Buczkowska-Radlińska
mesh_terms: D000328:Adult; D017607:Aluminum Compounds / Q000627:therapeutic use*; D017610:Calcium Compounds / Q000627:therapeutic use*; D003782:Dental Pulp / Q000033:anatomy & histology / Q000187:drug effects*; D003785:Dental Pulp Capping / Q000379:methods; D003789:Dental Pulp Exposure / Q000628:therapy; D003791:Dental Pulp Test; D003804:Dentin / Q000187:drug effects; D003809:Dentin, Secondary / Q000033:anatomy & histology / Q000187:drug effects; D004338:Drug Combinations; D006801:Humans; D009804:Odontoblasts / Q000166:cytology; D010087:Oxides / Q000627:therapeutic use*; D010147:Pain Measurement; D010486:Periapical Tissue / Q000187:drug effects; D057872:Pulp Capping and Pulpectomy Agents / Q000627:therapeutic use*; D017640:Silicates / Q000627:therapeutic use*; D014098:Toothache / Q000145:classification; D055815:Young Adult
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D057872:Pulp Capping and Pulpectomy Agents; D017640:Silicates; C086631:mineral trioxide aggregate; C506393:tricalcium silicate