title: Peptide profiling of the route from Mahoney to Sabin, and return.
abstract: In order to define poliovirus (PV) neurovirulence at the molecular level, we comparatively analyze the primary amino acid sequence of Mahoney, a neurovirulent PV strain, versus (i) Sabin, an attenuated PV strain, and (ii) IS1, a PV isolate obtained in temporal association to a paralysis event from a polio vaccinated subject. We identify and describe 12 pentapeptides that, originally present in the Mahoney sequence, are changed in the non-neurovirulent Sabin strain, and, successively, restored in IS1 strain.
authors.affiliation: Department of Biosciences, Biotechnologies and Pharmacological Sciences, University of Bari, Bari, Italy.
authors.forename: Darja
authors.initials: D
authors.lastname: Kanduc
authors.forename: Candida
authors.initials: C
authors.lastname: Fasano
authors.forename: Simona Lucia
authors.initials: SL
authors.lastname: Bavaro
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Novello
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Lucchese
authors.forename: Giovanni
authors.initials: G
authors.lastname: Capone
mesh_terms: D009842:Oligopeptides / Q000032:analysis* / Q000235:genetics; D017955:Poliovirus / Q000737:chemistry* / Q000235:genetics / Q000472:pathogenicity*; D014774:Virulence; D037521:Virulence Factors / Q000032:analysis* / Q000235:genetics
chemical_list: D009842:Oligopeptides; D037521:Virulence Factors
keywords: comparative peptide profiling; peptide matching analysis; poliovirus 1; poliovirus 1 attenuation; poliovirus 1 neurovirulence