title: Tomographic and functional findings in severe COPD: comparison between the wood smoke-related and smoking-related disease.
abstract: OBJECTIVE
  Wood smoke exposure is a risk factor for COPD. For a given degree of airway obstruction, the reduction in DLCO is smaller in individuals with wood smoke-related COPD than in those with smoking-related COPD, suggesting that there is less emphysema in the former. The objective of this study was to compare HRCT findings between women with wood smoke-related COPD and women with smoking-related COPD.
  
  
  METHODS
  Twenty-two women with severe COPD (FEV₁/FVC ratio < 70% and FEV₁ < 50%) were divided into two groups: those with wood smoke-related COPD (n = 12) and those with smoking-related COPD (n = 10). The two groups were compared regarding emphysema scores and airway involvement (as determined by HRCT); and functional abnormalities-spirometry results, DLCO, alveolar volume (VA), the DLCO/VA ratio, lung volumes, and specific airway resistance (sRaw).
  
  
  RESULTS
  There were no significant differences between the two groups in terms of FEV₁, sRaw, or lung hyperinflation. Decreases in DLCO and in the DLCO/VA ratio were greater in the smoking-related COPD group subjects, who also had higher emphysema scores, in comparison with the wood smoke-related COPD group subjects. In the wood smoke-related COPD group, HRCT scans showed no significant emphysema, the main findings being peribronchial thickening, bronchial dilation, and subsegmental atelectasis.
  
  
  CONCLUSIONS
  Female patients with severe wood smoke-related COPD do not appear to develop emphysema, although they do show severe airway involvement. The reduction in DLCO and VA, with a normal DLCO/VA ratio, is probably due to severe bronchial obstruction and incomplete mixing of inspired gas during the determination of single-breath DLCO.
authors.affiliation: Research Department, Colombian Pulmonology Foundation, Bogotá, Colombia. mgonzalez@neumologica.org
authors.forename: Mauricio
authors.initials: M
authors.lastname: González-García
authors.forename: Dario
authors.initials: D
authors.lastname: Maldonado Gomez
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Torres-Duque
authors.forename: Margarita
authors.initials: M
authors.lastname: Barrero
authors.forename: Claudia
authors.initials: C
authors.lastname: Jaramillo Villegas
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Pérez
authors.forename: Humberto
authors.initials: H
authors.lastname: Varon
mesh_terms: D000328:Adult; D001982:Bronchial Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D001261:Pulmonary Atelectasis / Q000000981:diagnostic imaging* / Q000209:etiology; D011653:Pulmonary Diffusing Capacity / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging* / Q000209:etiology; D012906:Smoke / Q000009:adverse effects*; D012907:Smoking / Q000009:adverse effects*; D013147:Spirometry; D014057:Tomography, X-Ray Computed; D014934:Wood
chemical_list: D012906:Smoke