title: Correlation of oxidative stress parameters and inflammatory markers in tunisian coronary artery disease patients.
abstract: BACKGROUND
  Oxidative stress is now recognized as being the cause and the consequence of cardiovascular diseases.
  
  
  OBJECTIVE
  The role that oxidative stress parameters and inflammatory markers may play in diabetes and related cardiovascular disease (CVD) among Tunisian coronary diabetic patients.
  
  
  METHODS
  We measured the erythrocyte glutathione peroxidase (GPX), the superoxide dismutase (SOD) activities and the plasmatic total antioxidant status (TAS) concentration by colorimetric methods, the hs-CRP by immunonephelometry assays.
  
  
  RESULTS
  TAS and GPX were significantly decreased among patients compared to the controls (1.14 ± 0.28 mmol/l vs 1.55 ± 0.35 mmol/l; 59.32 ± 10.72 U/gHb vs 149.19 ± 30.95 U/gHb). For the diabetic patients, TAS is correlated positively with hs-CRP (r=0.01, p<10(-3)). At the not diabetic subjects, TAS is correlated negatively with the hsCRP.
  
  
  CONCLUSIONS
  Determination of antioxidative defense markers contributes to understanding the effect of stress oxidative on the development and the prevention of cardiovascular disease.
authors.affiliation: Department of Clinical Biochemistry, CHU-Farhat Hached, Sousse, Tunisia;
authors.forename: Azza
authors.initials: A
authors.lastname: Dandana
authors.forename: Imen
authors.initials: I
authors.lastname: Gammoudi
authors.forename: Salima
authors.initials: S
authors.lastname: Ferchichi
authors.forename: Hinda
authors.initials: H
authors.lastname: Chahed
authors.forename: Hlima Ben
authors.initials: HB
authors.lastname: Limam
authors.forename: Faouzi
authors.initials: F
authors.lastname: Addad
authors.forename: Abdelhedi
authors.initials: A
authors.lastname: Miled
keywords: cardiovascular diseases; diabetes; glutathione peroxidase (GPX); high sensitivity C reactive protein (hs-CRP); total antioxidant status (TAS)