title: An update on antitumor activity of naturally occurring chalcones.
abstract: Chalcones, which have characteristic 1,3-diaryl-2-propen-1-one skeleton, are mainly produced in roots, rhizomes, heartwood, leaves, and seeds of genera Angelica, Sophora, Glycyrrhiza, Humulus, Scutellaria, Parartocarpus, Ficus, Dorstenia, Morus, Artocarpus, and so forth. They have become of interest in the research and development of natural antitumor agents over the past decades due to their broad range of mechanisms including anti-initiation, induction of apoptosis, antiproliferation, antimetastasis, antiangiogenesis, and so forth. This review summarizes the studies on the antitumor activity of naturally occurring chalcones and their underlying mechanisms in detail during the past decades.
authors.affiliation: School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: En-Hui
authors.initials: EH
authors.lastname: Zhang
authors.forename: Ru-Feng
authors.initials: RF
authors.lastname: Wang
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Guo
authors.forename: Bin
authors.initials: B
authors.lastname: Liu