title: [Chemical constituents of Nauclea officinalis].
abstract: In order to study the chemical constituents in the water extract of the stem of Nauclea officinalis, column chromatography over D101 macroporous resin and silica gel and an automatic purification system were used to isolate and purify the chemical constituents from the extract. Nine compounds were obtained. By analysis of the physicochemical properties and spectral data, their structures were identified as naucleamide G (1), 3, 4-dimethoxyphenol-beta-D-apiofuranosyl (1-->6)-beta-D-glucopyranoside (2), kelampayoside A (3), 3alpha, 5alpha-tetrahydrodeoxycordifoline lactam (4), naucleamide A-10-O-beta-D-glucopyranoside (5), pumiloside (6), 3-epi-pumiloside (7), strictosamide (8) and vincosamide (9), separately. Among them, compound 1 is a new compound, compound 2 was found in plants of the genus Nauclea for the first time, and compounds 3 and 4 were isolated from this plant for the first time.
authors.affiliation: Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
authors.forename: Fen-Xia
authors.initials: FX
authors.lastname: Zhu
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Song
authors.forename: Shu-Min
authors.initials: SM
authors.lastname: Ding
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Jia
mesh_terms: D002166:Camptothecin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D019666:Rubiaceae / Q000737:chemistry*; D014748:Vinca Alkaloids / Q000737:chemistry / Q000302:isolation & purification
chemical_list: C585594:3,4-dimethoxyphenol-beta-D-apiofuranosyl (1-6)-beta-D-glucopyranoside; C503145:3alpha-5alpha-tetrahydrodeoxycordifoline lactam; D002243:Carbolines; D005960:Glucosides; D026121:Indole Alkaloids; D014748:Vinca Alkaloids; C101212:kelampayoside A; C528626:naucleamide A-10-O-glucopyranoside; C585593:naucleamide G; C530309:pumiloside; C539462:strictosamide; D002166:Camptothecin