title: Plasmablastic lymphoma of the maxillary sinus in an HIV-negative patient: a case report and literature review.
abstract: Plasmablastic lymphoma (PBL) is a rare and aggressive variant of diffuse large B cell lymphoma. The prognosis of PBL patients is poor. The majority of patients succumb to a fulminant disease course, with most dying in the first year after diagnosis. The small number of HIV-negative PBL cases reported in the literature to date is composed of single case reports and small case series. Consequently, the natural history of the disease in HIV-negative individuals and the optimum treatment are not well characterized. Intensive induction chemotherapy has been associated with marked improved overall survival. However the optimal regimen has not been defined. We describe the third case of PBL of the maxillary sinus which occurred in a 24-year old HIV-negative man. We outline the clinicopathological features and report success using a hyper-CVAD regimen with 6 cycles and consolidation radiation therapy yielding a complete remission of four years.
authors.affiliation: Department of Internal Medicine, Lehigh Valley Health Network, 1255 S Cedar Crest Blvd Suite 3200, Allentown, PA 18104 USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Saraceni
authors.forename: Nicole
authors.initials: N
authors.lastname: Agostino
authors.forename: Dennis B
authors.initials: DB
authors.lastname: Cornfield
authors.forename: Ranju
authors.initials: R
authors.lastname: Gupta
keywords: HIV-negative; Maxillary sinus; PBL; Plasmablastic lymphoma