title: Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
abstract: The excellent biocompatibility and unique inclusion capability as well as powerful functionalization capacity of cyclodextrins and their derivatives make them especially attractive for engineering novel functional materials for biomedical applications. There has been increasing interest recently to fabricate supramolecular systems for drug and gene delivery based on cyclodextrin materials. This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery. First, we introduce cyclodextrin materials utilized for self-assembly. The fabrication technologies of supramolecular systems including nanoplatforms and hydrogels as well as their applications in nanomedicine and pharmaceutical sciences are then highlighted. At the end, the future directions of this field are discussed.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.
authors.forename: Jianxiang
authors.initials: J
authors.lastname: Zhang
authors.forename: Peter X
authors.initials: PX
authors.lastname: Ma
mesh_terms: D000818:Animals; D003505:Cyclodextrins / Q000737:chemistry*; D016503:Drug Delivery Systems; D050997:Nanomedicine
chemical_list: D003505:Cyclodextrins
keywords: Amphiphile; Cyclodextrin; Drug delivery; Gene therapy; Hydrogel; Nanomedicine; Nanoparticle; Self-assembly; Supramolecular system