title: [Selective serotonin reuptake inhibitor and gastrointestinal hemorrhage].
abstract: Selective serotonin reuptake inhibitors (SSRI) are widely used antidepressants characterized by less-frequent adverse effects compared with classical anti-depressive agents. On the other hand, SSRI can cause hemorrhagic events more due to impaired platelet aggregation induced by a depletion of serotonin in the peripheral platelet. Epidemiological studies have indicated that patients taking SSRI are predisposed to gastrointestinal hemorrhage, especially in case that nonsteroidal anti-inflammatory drugs are prescribed concomitantly. Here we describe a risk of the gastrointestinal hemorrhage in patients taking SSRI.
authors.affiliation: Department of Internal Medicine, Teikyo University.
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Koichiro
authors.initials: K
authors.lastname: Abe
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kuyama
mesh_terms: D001792:Blood Platelets / Q000187:drug effects; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors