title: [Comparison of the efficacy and safety of praziquantel administered in single dose of 40 versus 60 mg/kg for treating urinary schistosomiasis in Mauritania].
abstract: During the last twenty years, praziquantel (PZQ) was the drug of choice for the treatment of schistosomiasis in the majority of national programs. However, a lower rate of cure had been significantly noted on the left bank of the Senegal River. To explain this unusual rate of cure, the assumption of a possible resistance to the drug as well as under-dosing was considered. With an aim of testing this hypothesis of underdosing, we compared the amount of a single dose of 60 mg/kg of PZQ versus the standardized dose of 40 mg/kg used in curing urinary schistosomiasis in Mauritania. One hundred and fifty-one children aged from 10 to 19 years, including 77 in the group of 60 mg/kg and 74 in the group of 40 mg/ kg, were included in the study. The rates of cure were respectively 64.8% for 60 mg/kg and 67.5% for 40 mg/kg three weeks after the administration of the treatment without statistically significant difference. For the majority of the patients, the drug was well tolerated and no serious adverse events were noted; however, clinical signs in the form of abdominal pain associated or not with diarrhea and vomiting were noted. Praziquantel remains an effective and well-tolerated drug: the amount of 40 mg/kg of body weight can still be maintained for the treatment of schistosomiasis in Mauritania.
authors.affiliation: Service de parasitologie-mycologie, Institut national de recherches en santé publique (INRSP), BP 695, Nouakchott, Mauritanie. hmoukah2002@yahoo.fr
authors.forename: M
authors.initials: M
authors.lastname: Ouldabdallahi
authors.forename: B
authors.initials: B
authors.lastname: Ousmane
authors.forename: M
authors.initials: M
authors.lastname: Ouldbezeid
authors.forename: D
authors.initials: D
authors.lastname: Mamadou
authors.forename: L
authors.initials: L
authors.lastname: Konaté
authors.forename: L
authors.initials: L
authors.lastname: Chitsulo
mesh_terms: D000293:Adolescent; D000871:Anthelmintics / Q000008:administration & dosage* / Q000009:adverse effects*; D001835:Body Weight / Q000502:physiology; D002648:Child; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008435:Mauritania / Q000453:epidemiology; D011223:Praziquantel / Q000008:administration & dosage* / Q000009:adverse effects*; D012553:Schistosomiasis haematobia / Q000188:drug therapy* / Q000453:epidemiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000871:Anthelmintics; D011223:Praziquantel