title: Association of apolipoprotein b/apolipoprotein A1 ratio and coronary artery stenosis and plaques detected by multi-detector computed tomography in healthy population.
abstract: Despite the noninvasiveness and accuracy of multidetector computed tomography (MDCT), its use as a routine screening tool for occult coronary atherosclerosis is unclear. We investigated whether the ratio of apolipoprotein B (apoB) to apolipoprotein A1 (apoA1), an indicator of the balance between atherogenic and atheroprotective cholesterol transport could predict occult coronary atherosclerosis detected by MDCT. We collected the data of 1,401 subjects (877 men and 524 women) who participated in a routine health screening examination of Asan Medical Center. Significant coronary artery stenosis defined as > 50% stenosis was detected in 114 subjects (8.1%). An increase in apoB/A1 quartiles was associated with increased percentages of subjects with significant coronary stenosis and noncalcified plaques (NCAP). After adjustment for confounding variables, each 0.1 increase in serum apoB/A1 was significantly associated with increased odds ratios (ORs) for coronary stenosis and NCAP of 1.23 and 1.18, respectively. The optimal apoB/A1 ratio cut off value for MDCT detection of significant coronary stenosis was 0.58, which had a sensitivity of 70.2% and a specificity of 48.2% (area under the curve, 0.61; 95% CI, 0.58-0.63, P < 0.001). Our results indicate that apoB/A1 ratio is a good indicator of occult coronary atherosclerosis detected by coronary MDCT.
authors.affiliation: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Chang Hee
authors.initials: CH
authors.lastname: Jung
authors.forename: Jenie Yoonoo
authors.initials: JY
authors.lastname: Hwang
authors.forename: Mi Seon
authors.initials: MS
authors.lastname: Shin
authors.forename: Ji Hee
authors.initials: JH
authors.lastname: Yu
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Kim
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: Bae
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Yang
authors.forename: Joon-Won
authors.initials: JW
authors.lastname: Kang
authors.forename: Joong-Yeol
authors.initials: JY
authors.lastname: Park
authors.forename: Hong-Kyu
authors.initials: HK
authors.lastname: Kim
authors.forename: Woo Je
authors.initials: WJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D019540:Area Under Curve; D016893:Carotid Stenosis / Q000000981:diagnostic imaging*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012372:ROC Curve; D014057:Tomography, X-Ray Computed
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B
keywords: Apolipoproteins A1; Apolipoproteins B; Coronary Disease; Multidetector Computed Tomography