title: Genome-wide association study identifies possible genetic risk factors for colorectal adenomas.
abstract: BACKGROUND
  Colorectal cancer is the second leading cause of cancer-related death, and most colorectal cancer usually arises from colorectal adenomas. Removal of polyps reduces mortality from colorectal cancer. Colorectal adenomas are known to aggregate in families; however, the genetic determinants for risk of polyps are largely unknown.
  
  
  METHODS
  In this study, we used data from the Tennessee Colorectal Polyp Study and the Tennessee-Indiana Adenoma Recurrence Study to conduct a GWAS of adenoma cases and controls. Our design consisted of discovery and replication phases for a total of 2,551 Caucasian adenoma cases and 3,285 Caucasian controls. We carried out logistic regression to test for association in both the discovery and replication phase and further examined the results with meta-analysis.
  
  
  RESULTS
  No single nucleotide polymorphism (SNP) achieved a genome-wide significant P value; however, the most significantly associated SNPs were either previously associated with colorectal cancer in GWAS, such as rs10505477 in the gene POU5F1 [odds ratio (OR) = 0.87; 95% confidence interval (CI) 0.81-0.94; P = 4.4 × 10(-4)), or have been biologically linked to benign growths in other tissues, such as rs1919314 in the gene histone deacetylase 9 (OR = 1.32; 95% CI, 1.18-1.47; P = 1.1 × 10(-6)).
  
  
  CONCLUSIONS
  This study suggests that several SNPs may be related to adenoma risk and provides clues for future studies.
  
  
  CONCLUSIONS
  These results suggest that some known genetic risk factors of colorectal cancer are necessary but not sufficient for carcinogenesis.
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN 37203, USA. todd.l.edwards@vanderbilt.edu
authors.forename: Todd L
authors.initials: TL
authors.lastname: Edwards
authors.forename: Martha J
authors.initials: MJ
authors.lastname: Shrubsole
authors.forename: Qiuyin
authors.initials: Q
authors.lastname: Cai
authors.forename: Guoliang
authors.initials: G
authors.lastname: Li
authors.forename: Qi
authors.initials: Q
authors.lastname: Dai
authors.forename: Douglas K
authors.initials: DK
authors.lastname: Rex
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Ulbright
authors.forename: Zhenming
authors.initials: Z
authors.lastname: Fu
authors.forename: Ryan H
authors.initials: RH
authors.lastname: Delahanty
authors.forename: Harvey J
authors.initials: HJ
authors.lastname: Murff
authors.forename: Walter
authors.initials: W
authors.lastname: Smalley
authors.forename: Reid M
authors.initials: RM
authors.lastname: Ness
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000235:genetics*; D000368:Aged; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D056915:DNA Copy Number Variations; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013714:Tennessee / Q000453:epidemiology