title: Cognitive-behavioural interventions for mood and anxiety disorders in HIV: a systematic review.
abstract: BACKGROUND
  Mood and anxiety disorders are highly prevalent and comorbid with HIV/AIDS. However, there is a paucity of research on the effectiveness of cognitive-behavioural interventions (CBI) for common mental disorders in HIV-infected adults. The present study sought to review the existing literature on the use of CBI for depression and anxiety in HIV-positive adults and to assess the effect size of these interventions.
  
  
  METHODS
  We did duplicate searches of databases (from inception to 17-22 May 2012). The following online databases were searched: PubMed, The Cochrane Central Register of Controlled Trials and PsychArticles.
  
  
  RESULTS
  We identified 20 studies suitable for inclusion. A total of 2886 participants were enroled in these studies, of which 2173 participants completed treatment. The present review of the literature suggests that CBI may be effective in the treatment of depression and anxiety in individuals living with HIV/AIDS. Significant reductions in depression and anxiety were reported in intervention studies that directly and indirectly targeted depression and/or anxiety. Effect sizes ranged from 0.02 to 1.02 for depression and 0.04 to 0.70 for anxiety.
  
  
  CONCLUSIONS
  Some trials included an immediate postintervention assessment but no follow-up assessments of outcome. This omission makes it difficult to determine whether the intervention effects are sustainable over time.
  
  
  CONCLUSIONS
  The present review of the literature suggests that CBI may have a positive impact on the treatment of depression and anxiety in adults living with HIV/AIDS.
authors.affiliation: South African Research Chairs Initiative (SARChI), PTSD program, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa.
authors.forename: G
authors.initials: G
authors.lastname: Spies
authors.forename: L
authors.initials: L
authors.lastname: Asmal
authors.forename: S
authors.initials: S
authors.lastname: Seedat
mesh_terms: D001008:Anxiety Disorders / Q000150:complications / Q000628:therapy*; D002986:Clinical Trials as Topic; D015928:Cognitive Behavioral Therapy; D003863:Depression / Q000150:complications / Q000628:therapy*; D003866:Depressive Disorder; D015658:HIV Infections / Q000150:complications*; D006801:Humans
keywords: Anxiety; Cognitive therapy; Depression; HIV/AIDS; Psychotherapeutic interventions