title: Amide bond formation through iron-catalyzed oxidative amidation of tertiary amines with anhydrides.
abstract: A general and efficient method for amide bond synthesis has been developed. The method allows for synthesis of tertiary amides from readily available tertiary amines and anhydrides in the presence of FeCl2 as catalyst and tert-butyl hydroperoxide in water (T-Hydro) as oxidant. Mechanistic studies indicated that the in situ-generated α-amino peroxide of tertiary amine and iminium ion act as key intermediates in this oxidative transformation.
authors.affiliation: Department of Chemistry, Renmin University of China, Beijing 100872, China.
authors.forename: Yuanming
authors.initials: Y
authors.lastname: Li
authors.forename: Lina
authors.initials: L
authors.lastname: Ma
authors.forename: Fan
authors.initials: F
authors.lastname: Jia
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Li
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D000812:Anhydrides / Q000737:chemistry*; D002384:Catalysis; D005296:Ferrous Compounds / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000577:Amides; D000588:Amines; D000812:Anhydrides; D005296:Ferrous Compounds; C029451:ferrous chloride