title: [Study on solid dispersion of copovidone-based tanshinone II(A)].
abstract: OBJECTIVE
  To apply PVP-S630 in the preparation of tanshinone II(A) (TS II(A)) solid dispersion, in order to improve its dissolution in vitro and reduce the moisture absorption of the solid dispersion.
  
  
  METHODS
  Tanshinone II(A) solid dispersion was prepared by spray drying method. Such analytical methods as SEM, DSC, XRD were used to characterize their phases and detect their dissolution, moisture absorption and stability.
  
  
  RESULTS
  In the solid dispersion prepared with tanshinone II(A) and copovidone with proportion of 1:10, tanshinone II(A) was scattered on the surface of the carrier in the amorphous form, with a dissolution in vitro up to 100% at 0.5 h and a lower moisture absorption than PVP-K30 solid dispersion prepared with the same proportion. After a three-month accelerated stability test, it showed no significant change in drug dissolution and content.
  
  
  CONCLUSIONS
  The solid dispersion prepared with copovidone as the carrier can significantly improve the dissolution of tanshinone II(A), with a relatively low moisture absorption and high stability, thereby having a good prospect of application.
authors.affiliation: Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. jyanrong03@163.com
authors.forename: Yan-Rong
authors.initials: YR
authors.lastname: Jiang
authors.forename: Zhen-Hai
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Hai-Jiang
authors.initials: HJ
authors.lastname: Xia
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Jia
mesh_terms: D045784:Abietanes / Q000737:chemistry*; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004337:Drug Carriers / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D012995:Solubility; D013997:Time Factors; D014753:Vinyl Compounds / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D045784:Abietanes; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D004364:Pharmaceutical Preparations; D011759:Pyrrolidines; D014753:Vinyl Compounds; C402301:poly(vinylpyrrolidone-co-vinyl-acetate); C021751:tanshinone; D014867:Water