title: Myelodysplastic syndromes and autoimmune diseases--case series and review of literature.
abstract: Our objective was to recognize the association of autoimmune diseases (AD) in patients with myelodysplastic syndromes (MDS) and understand how this association could affect prognosis and management of both diseases. We describe our cohort of 10 patients and 34 patients reported in the English literature in addition to ten cohort studies. Interestingly, four cases showed improvement in AD after 5-azacitidine treatment. The mechanism(s) of the association between AD and MDS are discussed. Treatment could be targeted against AD, MDS or both, though based on recent reports, treating MDS with hypomethylating agents alone could improve the associated AD.
authors.affiliation: Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, USA.
authors.forename: Omar
authors.initials: O
authors.lastname: Al Ustwani
authors.forename: Laurie A
authors.initials: LA
authors.lastname: Ford
authors.forename: Sheila J N
authors.initials: SJ
authors.lastname: Sait
authors.forename: Anne Marie W
authors.initials: AM
authors.lastname: Block
authors.forename: Maurice
authors.initials: M
authors.lastname: Barcos
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Vigil
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Griffiths
authors.forename: James E
authors.initials: JE
authors.lastname: Thompson
authors.forename: Eunice S
authors.initials: ES
authors.lastname: Wang
authors.forename: Julian
authors.initials: J
authors.lastname: Ambrus
authors.forename: Meir
authors.initials: M
authors.lastname: Wetzler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000188:drug therapy; D001374:Azacitidine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000188:drug therapy; D011379:Prognosis; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000964:Antimetabolites, Antineoplastic; D001374:Azacitidine