title: Endocrine disruptors and human corpus luteum: in vitro effects of phenols on luteal cells function.
abstract: Endocrine disruptors are well known to impair fertility. The aim of the present study was to investigate the effects of bisphenol A (BPA) and nonylphenol (p-NP) on human luteal function in vitro. In particular, in luteal cells isolated from 21 human corpora lutea progesterone, prostaglandin (PG) F2α, PGE2 and vascular endothelial growth factor (VEGF) release, as well as VEGF expression were evaluated. BPA and p-NP negatively affected both luteal steroidogenesis and luteotrophic/ luteolytic factors balance, without influencing VEGF mRNA expression. Actually, BPA and p-NP impaired human luteal cells function in vitro, underlining the already suggested correlation between phenols and reproductive failure.
authors.affiliation: Istituto di Ginecologia ed Ostetricia, Università Cattolica del Sacro Cuore, Roma, Italy. romani.federica@gmail.com
authors.forename: Federica
authors.initials: F
authors.lastname: Romani
authors.forename: Anna
authors.initials: A
authors.lastname: Tropea
authors.forename: Elisa
authors.initials: E
authors.lastname: Scarinci
authors.forename: Cinzia
authors.initials: C
authors.lastname: Dello Russo
authors.forename: Lucia
authors.initials: L
authors.lastname: Lisi
authors.forename: Stefania
authors.initials: S
authors.lastname: Catino
authors.forename: Antonio
authors.initials: A
authors.lastname: Lanzone
authors.forename: Rosanna
authors.initials: R
authors.lastname: Apa
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000633:toxicity*; D002478:Cells, Cultured; D015237:Dinoprost / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D052244:Endocrine Disruptors / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008184:Luteal Cells / Q000187:drug effects* / Q000378:metabolism*; D010636:Phenols / Q000633:toxicity*; D011374:Progesterone / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D015237:Dinoprost; D015232:Dinoprostone; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D010636:Phenols; D011374:Progesterone; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; C025256:nonylphenol; C006780:bisphenol A; D000098826:Bisphenol A Compounds