title: Prognostic values of VEGF and IL-8 in malignant pleural effusion in patients with lung cancer.
abstract: OBJECTIVE
  The aim of this study was to evaluate the prognostic value of VEGF and IL-8 in pleural effusion in patients with lung cancer.
  
  
  METHODS
  Commercially available ELISA was used to determine VEGF and IL-8 levels.
  
  
  RESULTS
  The level of VEGF showed significant correlations with lymph node metastasis and distant metastasis. But, IL-8 was only correlated with lymph node metastasis. Univariate and multivariate analysis revealed elevated VEGF level was an independent predictor of shorter OS and DFS.
  
  
  CONCLUSIONS
  VEGF could be an important component that contributes to pleural effusion formation, and an important prognostic factor for lung cancer.
authors.affiliation: Department of Transfusion, The First Hospital of China Medical University, Shenyang, Liaoning Province, PR China. dayecheng_cmu@yahoo.cn
authors.forename: Daye
authors.initials: D
authors.lastname: Cheng
authors.forename: Hong
authors.initials: H
authors.lastname: Kong
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016066:Pleural Effusion, Malignant / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D016209:Interleukin-8; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A