title: [Indications of dexmedetomidine in the current sedoanalgesia tendencies in critical patients].
abstract: Recently, dexmedetomidine has been marketed in Spain and other European countries. The published experience regarding its use has placed dexmedetomidine on current trends in sedo-analgesic strategies in the adult critically ill patient. Dexmedetomidine has sedative and analgesic properties, without respiratory depressant effects, inducing a degree of depth of sedation in which the patient can open its eyes to verbal stimulation, obey simple commands and cooperate in nursing care. It is therefore a very useful drug in patients who can be maintained on mechanical ventilation with these levels of sedation avoiding the deleterious effects of over or infrasedation. Because of its effects on α2-receptors, it's very useful for the control and prevention of tolerance and withdrawal to other sedatives and psychotropic drugs. The use of dexmedetomidine has been associated with lower incidence of delirium when compared with other sedatives. Moreover, it's a potentially useful drug for sedation of patients in non-invasive ventilation.
authors.affiliation: Servicio de Medicina Intensiva, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.
authors.forename: M A
authors.initials: MA
authors.lastname: Romera Ortega
authors.affiliation: Servicio de Medicina Intensiva, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España. Electronic address: carlos.chamorroj@salud.madrid.org.
authors.forename: C
authors.initials: C
authors.lastname: Chamorro Jambrina
authors.affiliation: Servicio de Medicina Intensiva, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.
authors.forename: I
authors.initials: I
authors.lastname: Lipperheide Vallhonrat
authors.affiliation: Servicio de Medicina Intensiva, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.
authors.forename: I
authors.initials: I
authors.lastname: Fernández Simón
mesh_terms: D000698:Analgesia; D000700:Analgesics / Q000627:therapeutic use*; D016292:Procedural Sedation; D016638:Critical Illness; D054810:Deep Sedation; D020927:Dexmedetomidine / Q000627:therapeutic use*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine
keywords: Alfa2-agonistas; Alpha2-agonist; Critically ill patient; Dexmedetomidina; Dexmedetomidine; Mechanical ventilation; Paciente crítico; Sedación; Sedation; Ventilación mecánica