title: Methylated arginines and nitric oxide in end-stage renal disease: impact of inflammation, oxidative stress and haemodialysis.
abstract: OBJECTIVE
  To determine whether inflammation (C-reactive protein, CRP), oxidative stress (malondialdehyde, MDA) or haemodialysis (HD) affect associations between asymmetric (ADMA), symmetric (SDMA) dimethylarginine, NG-monomethyl-L-arginine (L-NMMA) and nitrite/nitrate (NOx) in end-stage renal disease (ESRD).
  
  
  METHODS
  Metabolites were measured pre-HD, after 1 hour and end-HD in 40 ESRD patients (age 63 ± 14 years).
  
  
  RESULTS
  Positive associations between NOx and ADMA (p = 0.04), SDMA (p < 0.001) and L-NMMA (p = 0.04) were observed pre-HD. Associations weakened during HD but were not significantly influenced by CRP or MDA.
  
  
  CONCLUSIONS
  HD, oxidative stress or inflammation did not significantly affect the positive associations between methylated arginines and NOx in ESRD.
authors.affiliation: Cardiology Department, Hospital Universitari Vall d'Hebrón, Barcelona, Spain.
authors.forename: Nadia
authors.initials: N
authors.lastname: Bouteldja
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Woodman
authors.forename: Chris L
authors.initials: CL
authors.lastname: Hewitson
authors.forename: Enric
authors.initials: E
authors.lastname: Domingo
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Barbara
authors.forename: Arduino A
authors.initials: AA
authors.lastname: Mangoni
mesh_terms: D000368:Aged; D001120:Arginine / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D008297:Male; D008745:Methylation; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D018384:Oxidative Stress; D006435:Renal Dialysis
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide; D001120:Arginine