title: A single compartment model of pacemaking in dissasociated substantia nigra neurons: stability and energy analysis.
abstract: Spontaneous oscillations in the mid-brain dopaminergic neurons are an important feature of motor control. The degeneration of these neurons is involved in movement disorders, particularly Parkinson's Disease. Modelling of this activity is an important part of developing an understanding of the pathogenic process. We develop a mathematical paradigm to describe this activity with a single compartment approach and a CellML version is made publicly available. The model explicitly describes the dynamics of the transmembrane potential with changes in the levels of important cations and is consistent with two major observations in the literature regarding its behaviour in the presence of channel blockers. Stability of the model behaviour is determined from the properties of its Monodromy matrix. We also discuss from the perspective of energy, a pharmacological intervention suggested in the treatment of Parkinson's Disease.
authors.affiliation: Hamilton Institute, NUI Maynooth, Co. Kildare, Ireland.
authors.forename: Febe
authors.initials: F
authors.lastname: Francis
authors.forename: Míriam R
authors.initials: MR
authors.lastname: García
authors.forename: Richard H
authors.initials: RH
authors.lastname: Middleton
mesh_terms: D000465:Algorithms; D001683:Biological Clocks / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002138:Calibration; D002412:Cations / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology; D008959:Models, Neurological; D015233:Models, Statistical; D009474:Neurons / Q000502:physiology*; D013378:Substantia Nigra / Q000166:cytology / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D002121:Calcium Channel Blockers; D002412:Cations; D013779:Tetrodotoxin