title: Sorting DNA with asymmetry: a new player in gene regulation?
abstract: In recent years, our views on how DNA and genes are organised and regulated have evolved significantly. One example is provided by reports that single DNA strands in the double helix could carry distinct forms of information. That chromatids carrying old and nascently replicated DNA strands are recognised by the mitotic machinery, then segregated in a concerted way to distinct daughter cells after cell division is remarkable. Notably, this phenomenon in several cases has been associated with the cell fate choice of resulting daughter cells. Here, we review the evidence for asymmetric or template DNA strand segregation in mammals with a focus on skeletal muscle.
authors.affiliation: Institut Pasteur, Stem Cells & Development, Department of Developmental & Stem Cell Biology, CNRS URA 2578, 25 rue du Dr. Roux, Paris 75015, France.
authors.forename: Brendan
authors.initials: B
authors.lastname: Evano
authors.forename: Shahragim
authors.initials: S
authors.lastname: Tajbakhsh
mesh_terms: D000818:Animals; D019070:Cell Lineage; D004247:DNA / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D018482:Muscle, Skeletal / Q000166:cytology / Q000502:physiology; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology
chemical_list: D004247:DNA