title: [Issues associated with sexual development during adolescence: from urological perspectives].
abstract: "Sex" is defined by several factors, such as chromosomes, gonads, and internal and external genitalia. Males basically have a Y chromosome and testes. The testis produces and secretes Mullerian inhibiting substance and testosterone. These two factors induce internal and external genitalia to develop into the male phenotype. The degree of sexual differentiation relates to the levels of Müllerian inhibiting substance and testosterone. The treatment strategy for patients with sexual differentiation should be decided based on the degree of abnormality of internal and external genitalia.
authors.affiliation: Department of Urology, NTT-East Corporation, Sapporo Medical Center.
authors.forename: Naoki
authors.initials: N
authors.lastname: Itoh
authors.forename: Naoya
authors.initials: N
authors.lastname: Masumori
mesh_terms: D000293:Adolescent; D012734:Disorders of Sex Development / Q000175:diagnosis*; D005260:Female; D006066:Gonads / Q000502:physiology*; D006801:Humans; D008297:Male; D012733:Sex Differentiation / Q000235:genetics / Q000502:physiology*; D046468:Sexual Development / Q000235:genetics / Q000502:physiology*; D013739:Testosterone / Q000096:biosynthesis
chemical_list: D013739:Testosterone