title: Oligonorbornenes with hammock-like crown ether pendants as artificial transmembrane ion channel.
abstract: Trimeric oligonorbornenes with hammock-like crown ether pendants 3b and 3c were selectively synthesized by cascade metathetical cyclopolymerization upon treatment with the first generation Grubbs catalyst. These crown-ether-containing oligonorbornenes are impregnated in egg yolk phosphatidylcholine (EYPC) liposome as an artificial ion channel. The efficiency of the sodium ion transport properties has been examined. Oligomer 3c having a polar hydroxy end group exhibits the highest transport efficiency, which is comparable with the best efficiencies reported in literature. The orientation of the crown ether moieties in these oligomers may be critical for the ion transport properties.
authors.affiliation: Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
authors.forename: Nai-Ti
authors.initials: NT
authors.lastname: Lin
authors.forename: Chen-Yu
authors.initials: CY
authors.lastname: Xie
authors.forename: Shou-Ling
authors.initials: SL
authors.lastname: Huang
authors.forename: Chung-Hsuan
authors.initials: CH
authors.lastname: Chen
authors.forename: Tien-Yau
authors.initials: TY
authors.lastname: Luh
mesh_terms: D002384:Catalysis; D043844:Crown Ethers / Q000737:chemistry*; D007473:Ion Channels / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry
chemical_list: D043844:Crown Ethers; D007473:Ion Channels; D008081:Liposomes; D010713:Phosphatidylcholines; C030011:carbene; D008697:Methane