title: [Sulfonamide allergy and cross-reactivity].
abstract: Beside beta-lactams, sulfonamide antibiotics are among the most common causes of drug allergy. Hypersensitivity to sulfonamides including IgE-mediated immediate, delayed cell-mediated mechanisms, and severe life-threatening reactions are still incompletely understood. Unfounded concerns of cross-reactivity between sulfonamide antibiotics and a variety of non-antibiotic-containing sulfonamide drugs render pharmacotherapy unnecessarily difficult. Here, the history, clinical manifestations, diagnosis and treatment of sulfonamide allergy are briefly reviewed.
authors.affiliation: Service d'Immunologie, et d'allergologie, HUG, 1211 Genève 14. peter.jandus@hcuge.ch
authors.forename: Peter
authors.initials: P
authors.lastname: Jandus
authors.forename: Thomas
authors.initials: T
authors.lastname: Harr
mesh_terms: D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D013449:Sulfonamides / Q000009:adverse effects*
chemical_list: D013449:Sulfonamides