title: Factors affecting the healing of the perineum following surgery.
abstract: BACKGROUND
  The aim of this study was to establish patient and procedural factors associated with the development of an unhealed perineum in patients undergoing a proctectomy or excision of an ileoanal pouch.
  
  
  METHODS
  A review of 194 case notes for procedures performed between 1997 and 2009 was carried out. All patients had at least 12 months' follow-up. Univariate and multivariate analyses were performed in 16 parameters. For those patients who developed an unhealed perineum, Cox regression analysis was performed to establish healing over a 12-month period.
  
  
  RESULTS
  Two hundred patients were included in the study, of which six had unknown wound status and were subsequently excluded. This left 194 study patients. Of these, 86 (44%) achieved primary wound healing with a fully healed perineum and 108 (56%) experienced primary wound failure. With reference to the latter, 63 (58%) healed by 12 months. Comparing patients with an initially intact perineum with those with initial wound failure showed pre-existing sepsis was highly relevant (odds ratio: 4.32, 95% confidence interval [CI]: 2.16-8.62, p<0.001). In patients who had an unhealed perineum initially, perineal sepsis and surgical treatment were both significantly associated with time to healing (hazard ratio [HR]: 0.54, 95% CI: 0.31-0.93, p=0.03; and HR: 0.42, 95% CI: 0.21-0.84, p=0.01).
  
  
  CONCLUSIONS
  The presence of pre-existing perineal sepsis is associated with an unhealed perineum following proctectomy in inflammatory bowel disease (IBD) and non-IBD surgery. Further studies are indicated to establish perineal sepsis as a causative factor.
authors.affiliation: North West London Hospitals NHS Trust, UK. brianip@nhs.net
authors.forename: B
authors.initials: B
authors.lastname: Ip
authors.forename: M
authors.initials: M
authors.lastname: Jones
authors.forename: P
authors.initials: P
authors.lastname: Bassett
authors.forename: R
authors.initials: R
authors.lastname: Phillips
mesh_terms: D003108:Colonic Diseases / Q000503:physiopathology / Q000601:surgery; D039021:Colonic Pouches / Q000502:physiology*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010502:Perineum / Q000502:physiology* / Q000601:surgery; D011183:Postoperative Complications / Q000503:physiopathology*; D012007:Rectum / Q000601:surgery*; D012189:Retrospective Studies; D018805:Sepsis / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology*