title: Primary Sclerosing Cholangitis: Current and Future Management Strategies.
abstract: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease. The etiology of this disorder is unknown and there are no effective medical therapies. PSC is associated with inflammatory bowel disease and an increased risk for hepatobiliary and colorectal malignancies. The aim of this review is to highlight the clinical features and diagnostic approach to patients with suspected PSC, characterize associated comorbidities, review screening strategies for PSC associated malignancies and review contemporary and future therapies.
authors.affiliation: Cholestatic Liver Diseases Study Group, Department of Gastroenterology and Hepatology, Mayo Clinic College of Medicine.
authors.forename: John E
authors.initials: JE
authors.lastname: Eaton
authors.forename: Jayant A
authors.initials: JA
authors.lastname: Talwalkar
keywords: Diagnosis; Management; Primary sclerosing cholangitis