title: Effects of age, sex, and sertraline administration on seizure-induced respiratory arrest in the DBA/1 mouse model of sudden unexpected death in epilepsy (SUDEP).
abstract: DBA/1 mice are susceptible to audiogenic seizure-induced respiratory arrest (S-IRA), leading to death, which is a model of human sudden unexpected death in epilepsy (SUDEP). Female DBA/1 mice exhibited 71% susceptibility to S-IRA on the third daily test when seizure testing began at postnatal day (PND) 24-30, which was slightly (>10%) but not significantly lower than males. When initial seizure testing was delayed (to >7 weeks of age), DBA/1 mice of both sexes exhibited significantly reduced S-IRA susceptibility, as compared to mice tested initially at PND 24-30. These sex and age issues had not been previously evaluated and may be important for the future use of this SUDEP model. We also observed that 30 min after administering a selective serotonin reuptake inhibitor (SSRI), sertraline (40, 50, or 75 mg/kg i.p.), a significantly reduced S-IRA incidence in DBA/1 mice occurred without blocking seizures, which may be relevant to SUDEP prevention.
authors.affiliation: Department of Pharmacology, Southern Illinois University School of Medicine, P.O. Box 19629, Springfield, IL 62794-9629, USA. cfaingold@siumed.edu
authors.forename: Carl L
authors.initials: CL
authors.lastname: Faingold
authors.forename: Marcus
authors.initials: M
authors.lastname: Randall
mesh_terms: D000161:Acoustic Stimulation / Q000009:adverse effects; D000375:Aging; D000818:Animals; D003645:Death, Sudden; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D020195:Epilepsy, Reflex / Q000150:complications / Q000209:etiology; D005260:Female; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D012131:Respiratory Insufficiency / Q000188:drug therapy* / Q000209:etiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use*; D012727:Sex Characteristics
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline