title: Colorectal cancer in inflammatory bowel disease: results of the 3rd ECCO pathogenesis scientific workshop (I).
abstract: Epidemiological studies demonstrate an increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). A detailed literature review was conducted on epidemiology, risk factors, pathophysiology, chemoprevention and outcomes of colorectal cancer (CRC) in IBD as part of the 3rd ECCO scientific pathogenesis workshop.
authors.affiliation: Hull & East Yorkshire Hospitals NHS Trust, Hull York Medical School, Hull, United Kingdom. Electronic address: Shaji.Sebastian@hey.nhs.uk.
authors.forename: Shaji
authors.initials: S
authors.lastname: Sebastian
authors.affiliation: Gastroenterology Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
authors.forename: Vincent
authors.initials: V
authors.lastname: Hernández
authors.affiliation: Division of Surgery, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, County Council of Östergötland, Linköping, Sweden.
authors.forename: Pär
authors.initials: P
authors.lastname: Myrelid
authors.affiliation: Service for Gastrointestinal Malignancies, Department of Gastroenterology & Liver Disease, Tel Aviv Sourasky Medical Center, Israel.
authors.forename: Revital
authors.initials: R
authors.lastname: Kariv
authors.affiliation: University of Ioannina, 1st Division of Internal Medicine and Hepato-Gastroenterology Unit, Greece.
authors.forename: Epameinondas
authors.initials: E
authors.lastname: Tsianos
authors.affiliation: Ankara University Medical School, Ibni Sina Hospital, Division of Gastroenterology, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Toruner
authors.affiliation: Department of Colorectal Surgery, University Hospital of Valle de Hebron, Barcelona, Spain.
authors.forename: Marc
authors.initials: M
authors.lastname: Marti-Gallostra
authors.affiliation: Dipartimento e Cattedra di Chirurgia Generale, Istituto Clinico Humanitas IRCCS, Università degli Studi di Milano, Rozzano, Milano, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Spinelli
authors.affiliation: Leiden University Medical Center, Department of Gastroenterology, Leiden, The Netherlands.
authors.forename: Andrea E
authors.initials: AE
authors.lastname: van der Meulen-de Jong
authors.affiliation: Department of Gastroenterology, Katip Celebi University, Ataturk Research and Teaching Hospital, Izmir, Turkey.
authors.forename: Elif Sarıtas
authors.initials: ES
authors.lastname: Yuksel
authors.affiliation: Christian Doppler Laboratory on Molecular Cancer Chemoprevention, Division of Gastroenterology, Medical University of Vienna, Vienna, Austria.
authors.forename: Christoph
authors.initials: C
authors.lastname: Gasche
authors.affiliation: Chair of Gastroenterology, "L. Sacco" University Hospital, Milan, Italy.
authors.forename: Sandro
authors.initials: S
authors.lastname: Ardizzone
authors.affiliation: Department of Gastroenterology, Istituto Clinico Humanitas, Milan, Italy. Electronic address: sdanese@hotmail.com.
authors.forename: Silvio
authors.initials: S
authors.lastname: Danese
mesh_terms: D017668:Age of Onset; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D015209:Cholangitis, Sclerosing / Q000453:epidemiology; D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D003226:Congresses as Topic; D003424:Crohn Disease / Q000453:epidemiology / Q000378:metabolism*; D005492:Folic Acid / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D019804:Mesalamine / Q000627:therapeutic use; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D016588:Anticarcinogenic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007155:Immunologic Factors; D019804:Mesalamine; D014580:Ursodeoxycholic Acid; D005492:Folic Acid
keywords: 5-ASA; 5-amino salicylic acid; AOM; Azoxymethane; CAC; CD; CIN; CRC; Chemoprevention; Chromosomal instability; Colitis-associated cancer; Colorectal cancer; Crohn's disease; DSS; Dextran sodium sulphate; Epidemiology; IBD; IC; IL; Indeterminate colitis; Inflammatory bowel disease; Interleukins; MRR; MSI; Microsatellite instability; Mortality rate ratio; NF-κB; Nuclear factor-κB; OR; Odds ratio; Outcomes; PSC; Pathogenesis; Primary sclerosing cholangitis; RR; Relative risk; SIR; Standardised incidence ratio; TGFβ; TLR; TNFα; Toll-like receptor; Transforming growth factor-β; Tumour necrosis factor-α; UC; Ulcerative colitis