title: The neural basis of cognitive change: reappraisal of emotional faces modulates neural source activity in a frontoparietal attention network.
abstract: Emotions can be regulated effectively via cognitive change, as evidenced by cognitive behavioural therapy. The neural correlates of cognitive change were investigated using reappraisal, a strategy that involves the reinterpretation of emotional stimuli. Hemodynamic studies revealed cortical structures involved in reappraisal and highlighted the role of the prefrontal cortex in regulating subcortical affective processing. Studies using event-related potentials elucidated the timing of reappraisal by showing effective modulation of the Late Positive Potential (LPP) after 300ms but also even earlier effects. The present study investigated the spatiotemporal dynamics of the cortical network underlying cognitive change via inverse source modelling based on whole-head magnetoencephalography (MEG). During MEG recording, 28 healthy participants saw angry and neutral faces and followed instructions designed to down- or up-regulate emotions via reappraisal. Differences between angry and neutral face processing were specifically enhanced during up-regulation, first in the parietal cortex during M170 and across the whole cortex during LPP-M, with particular involvement of the parietal and dorsal prefrontal cortex regions. Thus, our data suggest that the reappraisal of emotional faces involves specific modulations in a frontoparietal attention network.
authors.affiliation: Department of Child and Adolescent Psychiatry, University Hospital Münster, Schmeddingstr. 50, 48149 Münster, Germany. Electronic address: Ida.Wessing@ukmuenster.de.
authors.forename: Ida
authors.initials: I
authors.lastname: Wessing
authors.affiliation: Institute for Biomagnetism and Biosignalanalysis, University Hospital Münster, Malmedyweg 15, 48149 Münster, Germany. Electronic address: maimu@gmx.de.
authors.forename: Maimu A
authors.initials: MA
authors.lastname: Rehbein
authors.affiliation: Department of Child and Adolescent Psychiatry, University Hospital Münster, Schmeddingstr. 50, 48149 Münster, Germany; Department of Applied Health Sciences, Study Programme Occupational Therapy, University of Applied Sciences, Universitätsstraße 105, 44789 Bochum, Germany. Electronic address: Christian.Postert@ukmuenster.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Postert
authors.affiliation: Department of Child and Adolescent Psychiatry, University Hospital Münster, Schmeddingstr. 50, 48149 Münster, Germany. Electronic address: Furniss@ukmuenster.de.
authors.forename: Tilman
authors.initials: T
authors.lastname: Fürniss
authors.affiliation: Institute for Biomagnetism and Biosignalanalysis, University Hospital Münster, Malmedyweg 15, 48149 Münster, Germany. Electronic address: markus.junghoefer@uni-muenster.de.
authors.forename: Markus
authors.initials: M
authors.lastname: Junghöfer
mesh_terms: D000328:Adult; D001288:Attention; D001931:Brain Mapping / Q000379:methods; D004644:Emotions / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology; D005145:Face; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology*; D010775:Photic Stimulation; D013850:Thinking / Q000502:physiology*; D055815:Young Adult
keywords: Attention; Cognitive change; Emotion; Emotion regulation; Emotional faces; LPP; LPP-M; M170; MEG; Magnetoencephalography; N170; Reappraisal