title: Prothrombin complex concentrate for warfarin-induced bleeding in a patient with a mechanical aortic valve.
abstract: Reversal of anticoagulation-induced bleeding in the perioperative period can be challenging, particularly with an unstable patient with a mechanical valve. We present a case of life-threatening bleeding successfully managed with a prothrombin complex concentrate as an alternative to fresh frozen plasma.
authors.affiliation: The Ohio State University College of Medicine, OH, USA.
authors.forename: Rahul
authors.initials: R
authors.lastname: Kar
authors.forename: Erik
authors.initials: E
authors.lastname: Abel
authors.forename: Pamela
authors.initials: P
authors.lastname: Burcham
authors.forename: Michael S
authors.initials: MS
authors.lastname: Firstenberg
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D001014:Aortic Aneurysm / Q000601:surgery*; D001021:Aortic Valve / Q000601:surgery*; D001777:Blood Coagulation / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000627:therapeutic use*; D003029:Coagulants / Q000627:therapeutic use*; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation*; D006801:Humans; D019934:International Normalized Ratio; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000139:chemically induced / Q000175:diagnosis / Q000517:prevention & control*; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects*; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D001779:Blood Coagulation Factors; D003029:Coagulants; C025667:prothrombin complex concentrates; D014859:Warfarin
keywords: Bleeding; Blood; Coagulation/anticoagulation