title: Memory B cells in mouse models.
abstract: One of the principles behind vaccination, as shown by Edward Jenner in 1796, and host protection is immunological memory, and one of the cells central to this is the antigen-experienced memory B cell that responds rapidly upon re-exposure to the initiating antigen. Classically, memory B cells have been defined as progenies of germinal centre (GC) B cells expressing isotype-switched and substantially mutated B cell receptors (BCRs), that is, membrane-bound antibodies. However, it has become apparent over the last decade that this is not the only pathway to B cell memory. Here, we will discuss memory B cells in mice, as defined by (1) cell surface markers; (2) multiple layers; (3) formation in a T cell-dependent and either GC-dependent or GC-independent manner; (4) formation in a T cell-independent fashion. Lastly, we will touch upon memory B cells in; (5) mouse models of autoimmune diseases.
authors.affiliation: Department of Rheumatology and Inflammation Research, University of Gothenburg, Göteborg, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Bergmann
authors.forename: O
authors.initials: O
authors.lastname: Grimsholm
authors.forename: K
authors.initials: K
authors.lastname: Thorarinsdottir
authors.forename: W
authors.initials: W
authors.lastname: Ren
authors.forename: P
authors.initials: P
authors.lastname: Jirholt
authors.forename: I
authors.initials: I
authors.lastname: Gjertsson
authors.forename: I-L
authors.initials: IL
authors.lastname: Mårtensson
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000473:pathology*; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D015870:Gene Expression / Q000276:immunology; D018858:Germinal Center / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis; D007156:Immunologic Memory; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D007132:Immunoglobulin Isotypes; D011947:Receptors, Antigen, B-Cell