title: Non-Markovian Population Dynamics: Does it Help to Optimize the Chemotherapeutic Strategy?
abstract: A non-Markovian theory of population dynamics is to simulate the anti-cancer drug distribution between malignant and the hosting normal cell pools. The model takes into account both the cell life span and the proliferation rate differences. This new simulation approach looks promising for its potential to optimize a chemotherapeutic strategy by choosing the scheme with a higher degree of the drug-tumor selectivity. The pre-test designed simulation mode fits nicely the experimental data on Porphylleren-MC16 (PMC16) pharmacokinetics patterns including the allometric plots revealed for this novel medicinal nanoparticle possessing some anti-cancer potential and intervening into the oxygen-independent ATP production mechanisms.
authors.affiliation: N.N.Semenov Institute for Chemical Physics, Russian Academy of Sciences, Kosygin St.4, Moscow, Russia; ; Department of Medicinal Nanobiotechnologies, N.I.Pirogov Russian State Medical University, Ostrovityanov St.1, Moscow, Russia;
authors.forename: Dmitry A
authors.initials: DA
authors.lastname: Kuznetsov
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Roumiantsev
authors.forename: Majid
authors.initials: M
authors.lastname: Fallahi
authors.forename: Nima
authors.initials: N
authors.lastname: Amirshahi
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Makarov
authors.forename: Karina S
authors.initials: KS
authors.lastname: Kardashova
keywords: chemotherapeutic strategy; drug-tumor selectivity; population dynamics