title: Non-small-cell lung cancer: molecular targeted therapy and personalized medicine - drug resistance, mechanisms, and strategies.
abstract: Targeted therapies for cancer bring the hope of specific treatment, providing high efficacy and in some cases lower toxicity than conventional treatment. Although targeted therapeutics have helped immensely in the treatment of several cancers, like chronic myelogenous leukemia, colon cancer, and breast cancer, the benefit of these agents in the treatment of lung cancer remains limited, in part due to the development of drug resistance. In this review, we discuss the mechanisms of drug resistance and the current strategies used to treat lung cancer. A better understanding of these drug-resistance mechanisms could potentially benefit from the development of a more robust personalized medicine approach for the treatment of lung cancer.
authors.affiliation: Division of Pulmonary Sciences and Critical Care, University of Colorado, Aurora, CO, USA ; Program in Cancer Biology, University of Colorado, Aurora, CO, USA.
authors.forename: Marybeth
authors.initials: M
authors.lastname: Sechler
authors.forename: Amber D
authors.initials: AD
authors.lastname: Cizmic
authors.forename: Sreedevi
authors.initials: S
authors.lastname: Avasarala
authors.forename: Michelle
authors.initials: M
authors.lastname: Van Scoyk
authors.forename: Christine
authors.initials: C
authors.lastname: Brzezinski
authors.forename: Nicole
authors.initials: N
authors.lastname: Kelley
authors.forename: Rama Kamesh
authors.initials: RK
authors.lastname: Bikkavilli
authors.forename: Robert A
authors.initials: RA
authors.lastname: Winn
keywords: NSCLC; drug targets; lung cancer; personalized medicine