title: How should I treat a patient with typical angina, typical angiography, negative FFR?
abstract: BACKGROUND
  A 63-year-old man was referred for cardiac catheterisation for typical angina. At angiography, high-grade stenosis of the first diagonal branch, of the proximal circumflex and of an intermediate branch was found. After treatment of the diagonal branch, fractional flow reserve of the circumflex and intermediate branch was negative, but symptoms persisted.
  
  
  METHODS
  Physical examination, laboratory test, stress echocardiography, fractional flow reserve, coronary flow reserve.
  
  
  METHODS
  Complex interaction between epicardial stenosis and microvascular hyporeactivity.
  
  
  RESULTS
  Stenting.
authors.affiliation: Department of Cardiology and Angiology, University Medical Center, Mainz, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Jabs
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hink
authors.forename: Massimo
authors.initials: M
authors.lastname: Fineschi
authors.forename: Thomas
authors.initials: T
authors.lastname: Münzel
authors.forename: Tommaso
authors.initials: T
authors.lastname: Gori
authors.forename: Bon-Kwon
authors.initials: BK
authors.lastname: Koo
authors.forename: Ricardo
authors.initials: R
authors.lastname: Petraco
authors.forename: Sayan
authors.initials: S
authors.lastname: Sen
authors.forename: Sukhjinder
authors.initials: S
authors.lastname: Nijjer
authors.forename: Justin E
authors.initials: JE
authors.lastname: Davies
mesh_terms: D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation; D011237:Predictive Value of Tests; D015607:Stents; D016896:Treatment Outcome