title: Update on genetics of essential tremor.
abstract: Despite the research, few advances in the etiopathogenesis on essential tremor (ET) have been made to date. The high frequency of positive family history of ET and the observed high concordance rates in monozygotic compared with dizygotic twins support a major role of genetic factors in the development of ET. In addition, a possible role of environmental factors has been suggested in the etiology of ET (at least in non-familial forms). Although several gene variants in the LINGO1 gene may increase the risk of ET, to date no causative mutated genes have been identified. In this review, we summarize the studies performed on families with tremor, twin studies, linkage studies, case-control association studies, and exome sequencing in familial ET.
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
authors.forename: H
authors.initials: H
authors.lastname: Alonso-Navarro
authors.forename: E
authors.initials: E
authors.lastname: García-Martín
authors.forename: O
authors.initials: O
authors.lastname: Lorenzo-Betancor
authors.forename: P
authors.initials: P
authors.lastname: Pastor
authors.forename: J A G
authors.initials: JA
authors.lastname: Agúndez
mesh_terms: D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D020329:Essential Tremor / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D009154:Mutation / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D018433:Twin Studies as Topic
chemical_list: C482293:LINGO1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins
keywords: essential tremor; family history; genetic polymorphisms; genetics; linkage studies