title: Three new xanthones from the resin of Garcinia hanburyi.
abstract: Three new xanthones, 22,23-dihydroxydihydrogambogenic acid (1), 12-hydroxygambogefic acid A (2), and hanburixanthone (3), along with thirteen known compounds were isolated from the resin of Garcinia hanburyi. The structures of the new compounds were determined by detailed analysis of 1D and 2D NMR spectra and by comparison with related model compounds. All compounds were tested for their cytotoxicities against A549, HCT116, and MDA-MB-231, and most of them showed significant effects on the cell lines.
authors.affiliation: School of Pharmacy, Fudan University, Shanghai, China.
authors.forename: Yun-Xia
authors.initials: YX
authors.lastname: Deng
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Shao
authors.forename: Hui
authors.initials: H
authors.lastname: Xie
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Pan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D029760:Garcinia / Q000737:chemistry*; D045325:HCT116 Cells / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012116:Resins, Plant / Q000737:chemistry*; D044004:Xanthones / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C585791:12-hydroxygambogefic acid A; C585792:22,23-dihydroxydihydrogambogenic acid; D000972:Antineoplastic Agents, Phytogenic; D012116:Resins, Plant; D044004:Xanthones; C585790:hanburixanthone