title: Characterization of the Yoshida sarcoma: a model of cancer cachexia.
abstract: OBJECTIVE
  Cancer cachexia contributes significantly to morbidity and mortality in individuals with cancer. Currently, the mechanisms contributing to the development of cachexia are largely unknown, leading to a paucity of treatment and prevention options. Animal models are necessary in determining causal mechanisms and in testing potential treatments. While the Yoshida sarcoma has been utilized for more than 50 years, the cachexia syndrome produced by this model has not been well characterized in the literature.
  
  
  METHODS
  Tumor allografts were subcutaneously implanted in male Sprague Dawley rats (n = 16) and allowed to grow for 23 days. Control animals (n = 16) received a sham surgery. All rats were monitored daily for the presence of hallmark cachexia symptoms.
  
  
  RESULTS
  The results demonstrate the presence of decreased body weight gain, as well as lower levels of body adiposity and skeletal muscle mass, in tumor-bearing animals, as compared to controls.
  
  
  CONCLUSIONS
  While a large tumor burden was reached, the extent of cachexia was similar to that which is observed in many individuals with cancer cachexia. Future experiments utilizing this model are encouraged to identify mechanisms and effective treatment and prevention strategies.
authors.affiliation: Department of Psychological Sciences and Ingestive Behavior Research Center, Purdue University, 703 Third Street, West Lafayette, IN, 47907, USA, mhonors@purdue.edu.
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Honors
authors.forename: Kimberly P
authors.initials: KP
authors.lastname: Kinzig
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002100:Cachexia / Q000097:blood / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D004195:Disease Models, Animal; D004435:Eating; D064593:Heterografts; D007328:Insulin / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012517:Sarcoma, Yoshida / Q000097:blood / Q000378:metabolism* / Q000473:pathology*; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D007328:Insulin