title: Genetic polymorphisms of HSP70 in age-related cataract.
abstract: Polymorphisms have been identified in several HSP70 genes, which may affect HSP70 repair efficiency. We investigated the association of the polymorphisms in HSPA1A, HSPA1B, and HSPA1L genes in the HSPs repair pathway with the risk of cataract in a Chinese population. The study included 415 cataract patients and 386 controls. Genotyping was done by the polymerase chain reaction-restriction fragment length polymorphism method. HSPA1B 1267 A/A genotype seems to have a protective role against cataract (p = 0.014, odds ratio (OR) = 0.664, 95 % confidence intervals (CI) = 0.480-0.919), and the G allele (p = 0.057, OR = 1.216, 95 % CI = 0.999-1.479) does not seem to have a deleterious role in the development of cataract. Haplotypes with frequencies of GAT were significantly different than those of controls (p = 0.005). In HSPA1A G190C and HSPA1L T2437C polymorphisms, there were no significant differences in frequencies of the variant homozygous in patients compared to controls. We conclude that the A/A genotype of HSPA1B A1267G polymorphism seem to have a protective role against age-related cataract.
authors.affiliation: Eye Hospital, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150001, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: JianYing
authors.initials: J
authors.lastname: Gong
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.forename: DaXi
authors.initials: D
authors.lastname: Xue
authors.forename: HanRuo
authors.initials: H
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D000368:Aged; D000483:Alleles; D002386:Cataract / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: D018840:HSP70 Heat-Shock Proteins; C490786:HSPA1A protein, human; C525621:HSPA1B protein, human; C543454:HSPA1L protein, human