title: Rh-catalyzed direct enantioselective alkynylation of α-ketiminoesters.
abstract: A green way to amino acids: α-Tetrasubstituted α-amino acid derivatives are formed in high yield and enantioselectivity by using a Rh-catalyzed enantioselective alkynylation of α-ketiminoesters. This reaction, which involves a proton transfer and can be conducted at room temperature, has high substrate scope (see scheme; Cbz = benzyloxycarbonyl, Fmoc = 9-fluorenylmethyloxycarbonyl).
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, CREST, Maidaashi Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Morisaki
authors.forename: Masanao
authors.initials: M
authors.lastname: Sawa
authors.forename: Jun-ya
authors.initials: JY
authors.lastname: Nomaguchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Morimoto
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Kazushi
authors.initials: K
authors.lastname: Mashima
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohshima
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D004952:Esters; D010293:Pargyline / Q000031:analogs & derivatives / Q000737:chemistry; D011437:Propylamines / Q000737:chemistry; D011522:Protons; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D000596:Amino Acids; D056831:Coordination Complexes; D004952:Esters; D011437:Propylamines; D011522:Protons; C009054:propargylamine; D010293:Pargyline; D012238:Rhodium