title: [Predictors of adverse effects induced by antipsychotics].
abstract: Atypical antipsychotic drugs are superior to typical antipsychotic drugs in having a lower incidence of extrapyramidal side-effects, so atypical antipsychotic drugs have become the mainstream in the clinic. However, there is growing interest in the effects of antipsychotic treatment on other serious side-effects such as metabolic abnormalities, sexual function and QT prolongation. There is a need for biomarkers that can help in early identification of patients who are at risk for these serious side-effects. Hence, we have conducted psychopharmacological studies using OGTT, measurement of adipokines, holter ECG and genetic methods, aiming to identify key biomarkers to drive personalized medicine and new treatment development.
authors.affiliation: Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences.
authors.forename: Naoki
authors.initials: N
authors.lastname: Fukui
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Someya
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D006801:Humans; D011388:Prolactin / Q000097:blood; D018570:Risk Assessment
chemical_list: D014150:Antipsychotic Agents; D015415:Biomarkers; D011388:Prolactin; D005947:Glucose