title: Organelle asymmetry for proper fitness, function, and fate.
abstract: During cellular division, centrosomes are tasked with building the bipolar mitotic spindle, which partitions the cellular contents into two daughter cells. While every cell will receive an equal complement of chromosomes, not every organelle is symmetrically passaged to the two progeny in many cell types. In this review, we highlight the conservation of nonrandom centrosome segregation in asymmetrically dividing stem cells, and we discuss how the asymmetric function of centrosomes could mediate nonrandom segregation of organelles and mRNA. We propose that such a mechanism is critical for insuring proper cell fitness, function, and fate.
authors.affiliation: Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Dorothy A
authors.initials: DA
authors.lastname: Lerit
authors.forename: Jeremy T
authors.initials: JT
authors.lastname: Smyth
authors.forename: Nasser M
authors.initials: NM
authors.lastname: Rusan
mesh_terms: D000818:Animals; D019070:Cell Lineage; D006801:Humans; D022101:Microtubule-Organizing Center / Q000378:metabolism; D015388:Organelles / Q000378:metabolism* / Q000648:ultrastructure; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism