title: Methylated DNA and microRNA in body fluids as biomarkers for cancer detection.
abstract: Epigenetic alterations including DNA methylation and microRNAs (miRNAs) play important roles in the initiation and progression of human cancers. As the extensively studied epigenetic changes in tumors, DNA methylation and miRNAs are the most potential epigenetic biomarkers for cancer diagnosis. After the identification of circulating cell-free nuclear acids, increasing evidence demonstrated great potential of cell-free epigenetic biomarkers in the blood or other body fluids for cancer detection.
authors.affiliation: Laboratory of Cancer Biology, Department of Medical Oncology, Institute of Clinical Science, Sir Runrun Shaw Hospital, Medical School of Zhejiang University, Hangzhou 310029, China. jinhc@zju.edu.cn.
authors.forename: Yanning
authors.initials: Y
authors.lastname: Ma
authors.forename: Xian
authors.initials: X
authors.lastname: Wang
authors.forename: Hongchuan
authors.initials: H
authors.lastname: Jin
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D001826:Body Fluids / Q000378:metabolism*; D019175:DNA Methylation; D055088:Early Detection of Cancer / Q000379:methods; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*; D015203:Reproducibility of Results; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs