title: Characterization of xanthatin: anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo.
abstract: Anti-cancer investigations on Xanthatin mainly focus on in vitro experiments. We herein reported the anti-tumor effects of Xanthatin both in vitro and in vivo. MTS assay results showed that Xanthatin had a remarkable anti-proliferative effect on B16-F10 cells. Moreover, the expression of β-catenin was up-regulated both in vitro and in vivo. Animal studies further revealed that Xanthatin killed the tumor cells around the blood vessels which contributes to reduce microvascular density extremely. All these results indicate that Xanthatin inhibited murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt/β-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis.
authors.affiliation: Nanjing University of Chinese Medicine, Nanjing 210046, China.
authors.forename: Wei D
authors.initials: WD
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Ling G
authors.initials: LG
authors.lastname: Yan
authors.forename: Fang Z
authors.initials: FZ
authors.lastname: Yin
authors.forename: Jun S
authors.initials: JS
authors.lastname: Ruan
authors.forename: Zhi P
authors.initials: ZP
authors.lastname: Chen
authors.forename: Guang M
authors.initials: GM
authors.lastname: Yang
authors.forename: Cui P
authors.initials: CP
authors.lastname: Yan
authors.forename: Ding
authors.initials: D
authors.lastname: Zhao
authors.forename: Yin
authors.initials: Y
authors.lastname: Lu
authors.forename: Bao C
authors.initials: BC
authors.lastname: Cai
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008546:Melanoma, Experimental / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D011897:Random Allocation; D031210:Xanthium / Q000737:chemistry*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; C022186:xanthatin
keywords: Apoptosis; Melanoma; Wnt/β-catenin signaling; Xanthatin