title: The TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa?
abstract: We report that the metazoan Wnt protease and signaling inhibitor TIKI shares sequence homology with bacterial TraB/PrgY proteins, inhibitors of pheromone signaling essential for propagation of antibiotic resistance. Our analysis suggests that these proteins represent an ancient metalloprotease clan regulating cellular communications across biological kingdoms.
authors.affiliation: 4(th) and Aspen Life Sciences, Stillwater, MN 55082, USA. jfbazan@4thandaspen.com
authors.forename: J Fernando
authors.initials: JF
authors.lastname: Bazan
authors.forename: Bryan T
authors.initials: BT
authors.lastname: Macdonald
authors.forename: Xi
authors.initials: X
authors.lastname: He
mesh_terms: D000818:Animals; D001419:Bacteria / Q000201:enzymology*; D001426:Bacterial Proteins / Q000378:metabolism*; D020134:Catalytic Domain; D002450:Cell Communication; D024881:Drug Resistance, Bacterial / Q000235:genetics; D045726:Metalloproteases / Q000378:metabolism*; D010675:Pheromones / Q000037:antagonists & inhibitors; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D059748:Proteolysis; D017386:Sequence Homology, Amino Acid; D051153:Wnt Proteins / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D010675:Pheromones; D051153:Wnt Proteins; C082576:traB protein, Bacteria; D045726:Metalloproteases