title: Do socioeconomic inequalities in mortality vary between different Spanish cities? a pooled cross-sectional analysis.
abstract: BACKGROUND
  The relationship between deprivation and mortality in urban settings is well established. This relationship has been found for several causes of death in Spanish cities in independent analyses (the MEDEA project). However, no joint analysis which pools the strength of this relationship across several cities has ever been undertaken. Such an analysis would determine, if appropriate, a joint relationship by linking the associations found.
  
  
  METHODS
  A pooled cross-sectional analysis of the data from the MEDEA project has been carried out for each of the causes of death studied. Specifically, a meta-analysis has been carried out to pool the relative risks in eleven Spanish cities. Different deprivation-mortality relationships across the cities are considered in the analysis (fixed and random effects models). The size of the cities is also considered as a possible factor explaining differences between cities.
  
  
  RESULTS
  Twenty studies have been carried out for different combinations of sex and causes of death. For nine of them (men: prostate cancer, diabetes, mental illnesses, Alzheimer's disease, cerebrovascular disease; women: diabetes, mental illnesses, respiratory diseases, cirrhosis) no differences were found between cities in the effect of deprivation on mortality; in four cases (men: respiratory diseases, all causes of mortality; women: breast cancer, Alzheimer's disease) differences not associated with the size of the city have been determined; in two cases (men: cirrhosis; women: lung cancer) differences strictly linked to the size of the city have been determined, and in five cases (men: lung cancer, ischaemic heart disease; women: ischaemic heart disease, cerebrovascular diseases, all causes of mortality) both kinds of differences have been found. Except for lung cancer in women, every significant relationship between deprivation and mortality goes in the same direction: deprivation increases mortality. Variability in the relative risks across cities was found for general mortality for both sexes.
  
  
  CONCLUSIONS
  This study provides a general overview of the relationship between deprivation and mortality for a sample of large Spanish cities combined. This joint study allows the exploration of and, if appropriate, the quantification of the variability in that relationship for the set of cities considered.
authors.affiliation: Centro Superior de Investigación en Salud Pública, Av. Cataluña, 21, 46020 Valencia, Spain. miguel.a.martinez@uv.es
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Martinez-Beneito
authors.forename: Oscar
authors.initials: O
authors.lastname: Zurriaga
authors.forename: Paloma
authors.initials: P
authors.lastname: Botella-Rocamora
authors.forename: Marc
authors.initials: M
authors.lastname: Marí-Dell'Olmo
authors.forename: Andreu
authors.initials: A
authors.lastname: Nolasco
authors.forename: Joaquín
authors.initials: J
authors.lastname: Moncho
authors.forename: Antonio
authors.initials: A
authors.lastname: Daponte
authors.forename: M Felicitas
authors.initials: MF
authors.lastname: Domínguez-Berjón
authors.forename: Ana
authors.initials: A
authors.lastname: Gandarillas
authors.forename: Carmen
authors.initials: C
authors.lastname: Martos
authors.forename: Imanol
authors.initials: I
authors.lastname: Montoya
authors.forename: Pablo
authors.initials: P
authors.lastname: Sánchez-Villegas
authors.forename: Margarita
authors.initials: M
authors.lastname: Taracido
authors.forename: Carme
authors.initials: C
authors.lastname: Borrell
mesh_terms: D002908:Chronic Disease / Q000453:epidemiology; D002947:Cities / Q000706:statistics & numerical data*; D003430:Cross-Sectional Studies; D005260:Female; D054624:Health Status Disparities; D006801:Humans; D008297:Male; D009026:Mortality / Q000639:trends*; D011610:Psychosocial Deprivation; D012959:Socioeconomic Factors; D013030:Spain / Q000453:epidemiology; D014505:Urban Population