title: [Risk factors analysis of nonalcoholic fatty liver disease in Chinese men].
abstract: OBJECTIVE
  To explore risk factors of nonalcoholic fatty liver disease (NAFLD) in men in order to provide a theoretical basis for developing more effective NAFLD prevention and control strategies.
  
  
  METHODS
  One-hundred-and-two male patients (37.3+/-11.4 years old) hospitalized with NAFLD at the Dongnan Affiliated Hospital of Xiamen University between January 2009 and December 2010 were enrolled in the study, along with 23 age-matched healthy men (34.4+/-16.7 years old) to serve as the control group. The correlation(s) of body mass index (BMI; overweight defined as more than or equal to 22.717 kg/m2), waist circumference (WC), waist-to-hip ratio (WHR; central obesity defined as more than or equal to 0.866), fasting plasma glucose (FPG), triglyceride (TG), and total cholesterol (TC) with NAFLD was analyzed by univariate and multivariate logistic regression analyses. Receiver operating characteristic (ROC) curves were used to select proper thresholds for classification.
  
  
  RESULTS
  BMI, WC, WHR, FPG, TG, and TC were significantly different between the cases and controls (P less than 0.01). BMI, WC, WHR, TG and TC were identified as risk factors of NAFLD in these male cases (P less than 0.01). Relative to WC, TG and TC, both BMI and WHR had significant predictive value for NAFLD (odds ratio (OR) = 10.819 and 10.588, respectively). In addition, BMI had the highest diagnostic value for the prediction of NAFLD (area under the curve (AUC) = 0.931) followed by WHR (AUC = 0.879).
  
  
  CONCLUSIONS
  BMI, WC, WHR, TG, and TC are risk factors of NAFLD in Chinese men. BMI and WHR are effective anthroposomatology indices of NAFLD and may be useful factors on which to base future prevention and early diagnosis strategies for NAFLD in males.
authors.affiliation: Research and Therapy Center for Liver Disease, the Affiliated Dongnan Hospital of Xiamen University, Zhangzhou 363000, China.
authors.forename: Rui-Dan
authors.initials: RD
authors.lastname: Zheng
authors.forename: Qun-Ying
authors.initials: QY
authors.lastname: Zhuang
authors.forename: Jian-Neng
authors.initials: JN
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Lu
mesh_terms: D015992:Body Mass Index; D006801:Humans; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease; D012307:Risk Factors; D055105:Waist Circumference; D049629:Waist-Hip Ratio