title: Scaling the MAPK signaling threshold during CNS patterning.
abstract: Morphogenic gradients originating from signaling centers along the CNS developmental axes contribute to CNS patterning. Reporting in this issue of Developmental Cell, Lanctot et al. (2013) show that the Nde1-Lis1 complex interacts with Brap, a mitogen-activated protein kinase pathway negative regulator, to facilitate position-dependent modulation of neural progenitor fate and CNS patterning.
authors.affiliation: Neuroscience Center and the Department of Cell Biology and Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Plestant
authors.forename: E S
authors.initials: ES
authors.lastname: Anton