title: Celiac disease and autoimmunity: review and controversies.
abstract: Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. There is a strong linkage between CD and HLA-DQ2 and HLA-DQ8 haplotypes. Multiple case reports and small series suggest concordance between CD and other autoimmune disorders. This paper provides a brief overview of the pathogenesis of CD and reviews the literature regarding associations between CD and other autoimmune diseases, including the potential effects of gluten-free diet therapy on the prevention or amelioration of associated diseases.
authors.affiliation: Nationwide Children's Hospital, The Ohio State University School of Medicine, 700 Children's Drive, Columbus, OH 43205, USA. Jolanda.denham@nationwidechildrens.org
authors.forename: Jolanda M
authors.initials: JM
authors.lastname: Denham
authors.forename: Ivor D
authors.initials: ID
authors.lastname: Hill
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications*; D002446:Celiac Disease / Q000150:complications / Q000235:genetics / Q000276:immunology*; D055050:Diet, Gluten-Free; D006683:HLA-DQ Antigens / Q000235:genetics / Q000378:metabolism; D006801:Humans
chemical_list: D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; C109756:HLA-DQ8 antigen