title: MRI findings in a rottweiler with leukoencephalomyelopathy.
abstract: A 22 mo old male rottweiler presented with a 1 mo progressive history of general proprioceptive ataxia and upper motor neuron tetraparesis. Neurologic examination was consistent with a lesion affecting the first through fifth cervical spinal cord segments. MRI disclosed bilaterally symmetric hyperintensities on T2-weighted (T2W) images in the crus cerebri and pyramidal tracts of the brain and the dorsal portion of the lateral funiculi of the cervical spinal cord. Fifty days after initial presentation, the dog was euthanized due to disease progression. Pathologic examination of the central nervous system (CNS) revealed a bilaterally symmetric chronic leukoencephalomyelopathy (LEM) consistent with previous reports of LEM in rottweilers. To the authors' knowledge, this is the first report to describe the MRI characteristics of LEM in the rottweiler. The topography of the changes observed with MRI paralleled the pathologic changes, which were widespread loss of myelin, decreased axon numbers, and astroglial proliferation. Consequently, MRI of the CNS of affected rottweilers may aid in establishing a presumptive antemortem diagnosis of LEM.
authors.affiliation: Department of Small Animal Medicine and Surgery, University of Georgia, Athens, GA, USA.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Eagleson
authors.forename: Marc
authors.initials: M
authors.lastname: Kent
authors.forename: Simon R
authors.initials: SR
authors.lastname: Platt
authors.forename: Raquel R
authors.initials: RR
authors.lastname: Rech
authors.forename: Elizabeth W
authors.initials: EW
authors.lastname: Howerth
mesh_terms: D000818:Animals; D001259:Ataxia / Q000209:etiology; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology*; D004285:Dogs; D037901:Euthanasia, Animal; D056784:Leukoencephalopathies / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D008297:Male; D010291:Paresis / Q000209:etiology; D013116:Spinal Cord / Q000473:pathology; D013118:Spinal Cord Diseases / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*