title: Effects of different exercise protocols on ethanol-induced spatial memory impairment in adult male rats.
abstract: Chronic ethanol consumption is often accompanied by numerous cognitive deficits and may lead to long-lasting impairments in spatial learning and memory. The aim of the present study was to evaluate the therapeutic potential of regular treadmill exercise on hippocampal-dependent memory in ethanol-treated rats. Spatial memory was tested in a Morris Water Maze task. Adult male Wistar rats were exposed to ethanol (4 g/kg, 20% v/v for 4 weeks) and effects of three exercise protocols (pre-ethanol, post-ethanol and pre-to-post-ethanol treatment) were examined. Results showed that ethanol exposure resulted in longer escape latencies during the acquisition phase of the Morris Water Maze task. Moreover, all three exercise protocols significantly decreased the latency to locate the hidden platform. During the probe trial, ethanol led to decreased time spent in the target quadrant. In contrast, performance on the probe trial was significantly better in the rats that had done the post- and pre-to-post-ethanol, but not pre-ethanol, exercises. These findings suggest that treadmill running can attenuate the adverse effects of chronic ethanol exposure on spatial memory, and may serve as a non-pharmacological alcohol abuse treatment.
authors.affiliation: Faculty of Education and Psychology, University of Tabriz, Tabriz 5166614776, Iran.
authors.forename: T
authors.initials: T
authors.lastname: Hashemi Nosrat Abadi
authors.forename: L
authors.initials: L
authors.lastname: Vaghef
authors.forename: S
authors.initials: S
authors.lastname: Babri
authors.forename: M
authors.initials: M
authors.lastname: Mahmood-Alilo
authors.forename: M
authors.initials: M
authors.lastname: Beirami
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects* / Q000503:physiopathology / Q000523:psychology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000633:toxicity*; D003071:Cognition / Q000187:drug effects; D004924:Escape Reaction / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D005081:Exercise Therapy / Q000379:methods*; D006624:Hippocampus / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000209:etiology / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol