title: Neuroprotective compounds from the bulbs of Lycoris radiata.
abstract: Three new alkaloids (1-3) and one new phenolic glycoside (4), together with twenty five known alkaloids (5-29), were isolated from the bulbs of Lycoris radiata collected from Huaihua county of Hunan province, China. Their structures were elucidated on the basis of comprehensive NMR and MS spectroscopic analysis. The isolated alkaloids were evaluated for their neuroprotective activities against CoCl2, H2O2 and Aβ(25-35)-induced SH-SY5Y cell injuries. Compounds 1-3 showed significant neuroprotective effects against H2O2 or CoCl2-induced SH-SY5Y cell death, while compound 3 exhibited significant neuroprotective effects against Aβ(25-35)-induced SH-SY5Y cell injury. The known alkaloids 5-29 also exhibited similar bioactivities of different degrees. These findings highlight the fact that the over 100 Amaryllidaceae alkaloids may have a big potential to neuroprotective activity.
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, China.
authors.forename: Heng-Yi
authors.initials: HY
authors.lastname: Yu
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, China.
authors.forename: Zhuo-Yi
authors.initials: ZY
authors.lastname: Wang
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, China.
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Pi
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, China. Electronic address: ruanhl@mails.tjmu.edu.cn.
authors.forename: Han-Li
authors.initials: HL
authors.lastname: Ruan
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016229:Amyloid beta-Peptides; D016923:Cell Death; D002681:China; D003035:Cobalt; D006801:Humans; D006861:Hydrogen Peroxide; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031426:Lycoris / Q000737:chemistry*; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry
chemical_list: D047151:Amaryllidaceae Alkaloids; D016229:Amyloid beta-Peptides; D026121:Indole Alkaloids; D018696:Neuroprotective Agents; D010936:Plant Extracts; D003035:Cobalt; D006861:Hydrogen Peroxide; C018021:cobaltous chloride
keywords: Amaryllidaceae alkaloids; Lycoris radiata; Neuroprotective activity