title: Long-term results of endoscopic sinus surgery-oriented treatment for chronic rhinosinusitis with asthma.
abstract: OBJECTIVE
  The aims of this study were to evaluate the efficacy of functional endoscopic sinus surgery (FESS)-oriented multimodality treatment in chronic rhinosinusitis (CRS) patients with asthma and its impact on asthma.
  
  
  METHODS
  Prospective, nonrandomized cohort.
  
  
  METHODS
  Twenty-seven CRS patients with asthma who underwent FESS with postoperative topical corticosteroid spray were evaluated preoperatively; 25 of them were evaluated 1 year and 3 years postoperatively. CRS was evaluated by visual analogue scale, clinical control of CRS, and objective measurement endoscopy Lund-Kennedy scores. Asthma was assessed by subjective asthma control test and asthma control level, also by objective antiasthma medication use and pulmonary function tests.
  
  
  RESULTS
  VAS scores of general symptoms (8.09 ± 0.87 preoperatively) were significantly improved at 1 year (2.94 ± 2.21) and 3 years (3.77 ± 2.16) postoperation (P = .000). No difference in these items was found between 1 year and 3 years (P = .463). Endoscopy Lund-Kennedy scores at 1 year (4.34 ± 3.09) and 3 years (5.80 ± 3.38) postoperatively were significantly better (9.33 ± 2.03 preoperatively, P = .000), and there was no difference between 1 year and 3 years of follow-up (P > .05). Significantly, asthma control level improved postoperatively (P = .025). However, antiasthma drug and pulmonary function showed no significant change postoperatively (P > .05).
  
  
  CONCLUSIONS
  FESS-oriented multimodality treatment improves CRS with asthma significantly and persistently. Asthma control level improved. Antiasthma medication use and pulmonary function remained stable.
authors.affiliation: Department of Otolaryngology Hospital and Otolaryngology Institute, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
authors.forename: Feng-Hong
authors.initials: FH
authors.lastname: Chen
authors.forename: Ke-Jun
authors.initials: KJ
authors.lastname: Zuo
authors.forename: Yu-Biao
authors.initials: YB
authors.lastname: Guo
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Li
authors.forename: Geng
authors.initials: G
authors.lastname: Xu
authors.forename: Rui
authors.initials: R
authors.lastname: Xu
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Shi
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications* / Q000188:drug therapy*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D059747:Nasal Surgical Procedures / Q000379:methods*; D011446:Prospective Studies; D012220:Rhinitis / Q000150:complications* / Q000601:surgery*; D012852:Sinusitis / Q000150:complications* / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome
keywords: Chronic rhinosinusitis; aspirin intolerance; asthma; nasal polyps; sinus surgery