title: In situ expression of heat-shock proteins and 3-nitrotyrosine in brains of young rats exposed to a WiFi signal in utero and in early life.
abstract: The bioeffects of exposure to Wireless High-Fidelity (WiFi) signals on the developing nervous systems of young rodents was investigated by assessing the in vivo and in situ expression levels of three stress markers: 3-Nitrotyrosine (3-NT), an oxidative stress marker and two heat-shock proteins (Hsp25 and Hsp70). These biomarkers were measured in the brains of young rats exposed to a 2450 MHz WiFi signal by immunohistochemistry. Pregnant rats were first exposed or sham exposed to WiFi from day 6 to day 21 of gestation. In addition three newborns per litter were further exposed up to 5 weeks old. Daily 2-h exposures were performed blind in a reverberation chamber and whole-body specific absorption rate levels were 0, 0.08, 0.4 and 4 W/kg. 3-NT and stress protein expression was assayed in different areas of the hippocampus and cortex. No significant difference was observed among exposed and sham-exposed groups. These results suggest that repeated exposure to WiFi during gestation and early life has no deleterious effects on the brains of young rats.
authors.affiliation: Bordeaux University, IMS Laboratory UMR 5218 CNRS, Bioelectronics group, IPB-ENSCBP, France.
authors.forename: Saliha
authors.initials: S
authors.lastname: Aït-Aïssa
authors.forename: Florence Poulletier
authors.initials: FP
authors.lastname: de Gannes
authors.forename: Murielle
authors.initials: M
authors.lastname: Taxile
authors.forename: Bernard
authors.initials: B
authors.lastname: Billaudel
authors.forename: Annabelle
authors.initials: A
authors.lastname: Hurtier
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Haro
authors.forename: Gilles
authors.initials: G
authors.lastname: Ruffié
authors.forename: Axel
authors.initials: A
authors.lastname: Athané
authors.forename: Bernard
authors.initials: B
authors.lastname: Veyret
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lagroye
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000528:radiation effects*; D004622:Embryo, Mammalian / Q000378:metabolism / Q000528:radiation effects; D005260:Female; D005786:Gene Expression Regulation / Q000528:radiation effects*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000378:metabolism; D059015:Wireless Technology
chemical_list: D006360:Heat-Shock Proteins; C002744:3-nitrotyrosine; D014443:Tyrosine