title: Rejuvenating SIRT1 activators.
abstract: Whether the red wine component resveratrol directly activates the NAD(+)-dependent protein deacetylase SIRT1 has been debated. A recent study by Hubbard et al. (2013) strengthens the case that SIRT1-activating compounds (STACs) function as positive allosteric regulators of SIRT1 and thereby regulate mitochondrial function.
authors.affiliation: Gladstone Institutes, University of California, San Francisco, CA 94158, USA.
authors.forename: Philipp
authors.initials: P
authors.lastname: Gut
authors.forename: Eric
authors.initials: E
authors.lastname: Verdin