title: [Primary bone marrow CD8 cytotoxic T-cell lymphoma coexpressed CD20: a case report and literatures review].
abstract: OBJECTIVE
  To report the diagnosis, differential diagnosis and treatment of a rare case of primary bone marrow CD8+ cytotoxic T-cell lymphoma coexpressed CD20.
  
  
  METHODS
  The clinical characteristics, therapeutic course and the outcome of this patient were reviewed. Meanwhile, a series of examinations including morphology, flow cytometry, immunohistochemistry and molecular biology of bone marrow and skin samples were also performed.
  
  
  RESULTS
  Bone marrow biopsy showed an extensive involvement by abnormal T lymphocytes. Flow cytometry and immunohistochemistry showed weakly positive CD20, CD8(+), CD2(+), CD3(+), CD5(+), TIA(+), PAX-5(-), CD4(-), CD56(-), CD57(-), CD30(-), ALK-1(-), P53(-), TdT(-), Ki-67≈5%. A final diagnosis of primary bone marrow CD8+ cytotoxic T-cell lymphoma coexpressed CD20 was made. The patient initially presented a relatively indolent course was, but he was expired in the end 3 years later due to extensive involvements of skin and other organs though timely therapy was administrated.
  
  
  CONCLUSIONS
  Primary bone marrow CD8 cytotoxic T-cell lymphoma coexpressed CD20 was encountered rarely in clinical practice, which might be a challenging in terms of diagnosis and differential diagnosis. Further investigation of pathogenesis and therapeutic strategies of this rare disease was warranted.
authors.affiliation: Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
authors.forename: Ya-Qin
authors.initials: YQ
authors.lastname: Zhi
authors.forename: Yong
authors.initials: Y
authors.lastname: Yu
authors.forename: Yi-zhuo
authors.initials: YZ
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
mesh_terms: D018951:Antigens, CD20 / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D006801:Humans; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013602:T-Lymphocytes, Cytotoxic / Q000378:metabolism / Q000473:pathology
chemical_list: D018951:Antigens, CD20