title: Nutraceutical potential of polyphenolic fractions from Annurca apple (M. pumila Miller cv Annurca).
abstract: The capacities of polyphenolic extracts from Annurca apple peel and flesh to inhibit the glucose and cholesterol uptake by HepG2 cells were evaluated, and compared with those of other conventional cultivars, such as Red Delicious (RD), Pink Lady (PL), Fuji (F) and Golden Delicious (GD). RD peels exhibited the best hypoglycaemic effects, while Annurca flesh appeared the most active in reducing cell cholesterol uptake among the cultivars tested. The influence of the apple polyphenolic extracts on the cell proliferation and oxidative stress was also evaluated. Particularly, RD, Annurca and PL peels decreased proliferation by a 62.5%, 48.0% and 37.5%, respectively, probably due to their prooxidant capacity. Conversely, flesh extracts appeared more protective of cells than peels: Annurca and RD, particularly, proved to be able of increasing proliferation by a 32.2% and 11.1%, respectively, probably due to their capacity of reducing cell physiological radical levels of a 33.3% and 19.9%, respectively.
authors.affiliation: Department of Medicinal Chemistry, Università di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy. giancarlo.tenore@unina.it
authors.forename: Gian Carlo
authors.initials: GC
authors.lastname: Tenore
authors.forename: Pietro
authors.initials: P
authors.lastname: Campiglia
authors.forename: Paola
authors.initials: P
authors.lastname: Stiuso
authors.forename: Alberto
authors.initials: A
authors.lastname: Ritieni
authors.forename: Ettore
authors.initials: E
authors.lastname: Novellino
mesh_terms: D001692:Biological Transport / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D019587:Dietary Supplements / Q000032:analysis*; D005638:Fruit / Q000737:chemistry / Q000145:classification; D005947:Glucose / Q000378:metabolism; D056945:Hep G2 Cells; D006801:Humans; D027845:Malus / Q000737:chemistry* / Q000145:classification; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000032:analysis* / Q000494:pharmacology; D059808:Polyphenols / Q000032:analysis* / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D059808:Polyphenols; D005947:Glucose