title: Anosmia and an uncommon nonsteroidal anti-inflammatory drug reaction in a 38-year-old man.
abstract: Anosmia with asthma and nasal polyposis raises suspicion for aspirin-exacerbated respiratory disease (AERD). Guidelines for desensitization of patients with AERD to prevent recurrent nasal polyposis and improve upper and lower respiratory symptoms are well established. We present a patient with an uncommon reaction to acetylsalicylic acid (ASA) and nonsteroidal anti-inflammatory drugs who required deviation from the standard ASA desensitization approach.
authors.affiliation: Department of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, MI, USA. aleyton@med.umich.edu
authors.forename: Aimee L
authors.initials: AL
authors.lastname: Speck
authors.forename: James L
authors.initials: JL
authors.lastname: Baldwin
mesh_terms: D000328:Adult; D000799:Angioedema / Q000139:chemically induced / Q000150:complications; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D055963:Asthma, Aspirin-Induced / Q000150:complications / Q000175:diagnosis; D004342:Drug Hypersensitivity / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D000857:Olfaction Disorders / Q000139:chemically induced* / Q000150:complications; D012220:Rhinitis / Q000139:chemically induced / Q000150:complications; D014581:Urticaria / Q000139:chemically induced / Q000150:complications
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin