title: The newest member of the VEGF family.
abstract: In this issue of Blood, Singh et al establish the existence of a new soluble isoform of vascular endothelial growth factor receptor 3 (sVEGFR-3), which is synthesized and secreted by corneal epithelial cells; they show that sVEGFR-3 modulates lymphangiogenesis by impounding vascular endothelial growth factor (VEGF) C and rendering it unable to activate its cognate receptors, thereby maintaining the natural alymphatic disposition of the cornea.
authors.affiliation: University of Kentucky.
authors.forename: Romulo J C
authors.initials: RJ
authors.lastname: Albuquerque
mesh_terms: D000818:Animals; D003315:Cornea; D006801:Humans; D042583:Lymphangiogenesis / Q000235:genetics*; D040321:Vascular Endothelial Growth Factor Receptor-3 / Q000502:physiology*
chemical_list: D040321:Vascular Endothelial Growth Factor Receptor-3