title: [Dosimetric comparing between protons beam and photons beam for lung cancer radiotherapy: a meta-analysis].
abstract: OBJECTIVE
  The clinical evidences are not sufficient on the proton beam therapy of lung cancer for lacking of the RCTs on the comparing the proton with the photon beam in lung cancer radiotherapy. The aim of this study is to evaluate the dosimetry superiority of the proton beam and provide more valuable evidences to the clinical researches.
  
  
  METHODS
  Clinical trails of dosimetric comparing between protons beam and photons beam for lung cancer radiotherapy were obtained from the Cochrane library, Pubmed, EMbase, CBM, CNKI, VIP, and Wan Fang databases. The data included in the study were evaluated and analyzed using the Cochrane Collaboration's RevMan 5.2 software.
  
  
  RESULTS
  Six trails were included. Compared to photon therapy (three-dimensional conformal photon radiotherapy, 3D-CRT), the proton therapy had a significantly lower total lung Dmean (MD=-4.15, 95%CI: -5.56--2.74, P<0.001) and V20, V10, V5 (MD=-10.92, 95%CI: -13.23--8.62, P<0.001); The V20, V10, V5 significantly decreased in proton therapy group. Compared to photon therapy (intensity-modulated photon radiotherapy, IMRT), V20, V10, V5 were also significantly lowered in proton therapy group (MD=-3.70, 95%CI: -5.31--2.10, P<0.001; MD=-8.86, 95%CI: -10.74--6.98, P<0.001; MD=-20.13, 95%CI: -27.11--13.14, P<0.001); The esophagus Dmean was not lowered, while the heart Dmean decreased in proton therapy group.
  
  
  CONCLUSIONS
  Comparing to photon beam radiotherapy (3D-CRT and IMRT), proton beam therapy is advantageous in dosimetry of the lung cancer radiotherapy and recommended for clinical applying.
authors.affiliation: Department of Radiation Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Guangwei
authors.initials: G
authors.lastname: Tian
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Guang
authors.initials: G
authors.lastname: Li
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D017785:Photons / Q000009:adverse effects / Q000627:therapeutic use*; D061766:Proton Therapy / Q000009:adverse effects / Q000379:methods*; D011874:Radiometry; D011879:Radiotherapy Dosage