title: The tale of a person and a peptide: Wylie W. Vale Jr. and the role of corticotropin-releasing factor in the stress response.
abstract: The studies reviewed in this article certainly do not constitute the entire body of research conducted by Wylie Vale's group and his collaborators, they might constitute turning points in CRF research. In addition, the studies reviewed here show that, over the course of 31 years (from 1981 to 2012), Wylie tirelessly pursued the answers to fundamental questions regarding CRF. He was a man whose drive never seemed to falter.
authors.affiliation: Laboratory of Chemical Neuroanatomy, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 2415, Ed. B-III, Lab 106, 05508-000 São Paulo, SP, Brazil; Center of Neuroscience and Behavior, Institute of Psychology, University of São Paulo, Av. Prof. Mello Moraes, 1721, Bloco C, 05508-030 São Paulo, SP, Brazil. Electronic address: jcbitten@icb.usp.br.
authors.forename: Jackson C
authors.initials: JC
authors.lastname: Bittencourt
mesh_terms: D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000266:history*; D004704:Endocrinology / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009462:Neurology / Q000266:history*; D013312:Stress, Physiological; D014481:United States
chemical_list: D003346:Corticotropin-Releasing Hormone
keywords: ACTH; CRF; CRFR1; CRFR2; Corticotropin-releasing factor; Corticotropin-releasing factor receptors; Corticotropin-releasing factor-binding protein; HPA; LNSF; Laboratories for Peptide Biology (Clayton Foundation, Salk Institute for Biological Studies); Laboratory of Neuronal Structure and Function; PBL; Stress response; Urocortin; Wylie Vale; adrenocorticotropic hormone; corticotropin-releasing factor; corticotropin-releasing factor receptor type 1; corticotropin-releasing factor receptor type 2; hypothalamic-pituitary-adrenal