title: Maintenance of the remission stage of Crohn's disease with adalimumab therapy during pregnancy.
abstract: A 25-year-old pregnant woman complained of abdominal pain and diarrhea. Total colonoscopy provided a diagnosis of Crohn's disease (CD) of the large intestine (Crohn's colitis). Because the patient was allergic to mesalazine, adalimumab (ADA) was used as maintenance therapy during pregnancy, following prednisolone as remission induction therapy. Remission of the patient's CD was maintained with ADA, and the patient delivered a baby girl without any difficulties. Remission of the patient's CD continued to be maintained with the administration of ADA after childbirth. We believe that this is the first report of the use of ADA therapy in a pregnant CD patient in Japan.
authors.affiliation: Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan. tmizoshi@med.nagoya-cu.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Mizoshita
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanida
authors.forename: Hironobu
authors.initials: H
authors.lastname: Tsukamoto
authors.forename: Keiji
authors.initials: K
authors.lastname: Ozeki
authors.forename: Takahito
authors.initials: T
authors.lastname: Katano
authors.forename: Masahide
authors.initials: M
authors.lastname: Ebi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Mori
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kataoka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamiya
authors.forename: Takashi
authors.initials: T
authors.lastname: Joh
mesh_terms: D000068879:Adalimumab; D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D001781:Blood Component Removal; D003113:Colonoscopy; D003131:Combined Modality Therapy; D003424:Crohn Disease / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000628:therapy; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D060046:Maintenance Chemotherapy; D019804:Mesalamine / Q000009:adverse effects / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000628:therapy; D012074:Remission Induction
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D019804:Mesalamine; D011239:Prednisolone; D000068879:Adalimumab