title: Confirmed efficacy of topical nifedipine in the treatment of facial wrinkles.
abstract: BACKGROUND
  Over the past two decades, there has been increasing demand for aesthetic procedures to reverse the effects of aging, particularly in the facial area. Recently, topical nifedipine has been proposed for its anti-wrinkle efficacy.
  
  
  OBJECTIVE
  To confirm the anti-wrinkle efficacy of a 0.5% nifedipine-based topical formulation.
  
  
  METHODS
  A randomized study was conducted in 20 healthy female volunteers, aged between 45 and 60 years, with moderate to moderately severe facial wrinkles. 10 volunteers applied a 0.5% nifedipine cream and 10 volunteers applied a good moisturizer twice daily for 90 days. The aesthetic improvement was evaluated by a blinded investigator using the Wrinkle Severity Rating Scale (WSRS). Anti-wrinkles effectiveness was also objectively assessed by measuring transepidermal water loss (TEWL), moisture levels of the stratum corneum, skin viscoelasticity and skin folding capacity by instrumental analysis.
  
  
  RESULTS
  Post-treatment WSRS score was significantly lower than the baseline WSRS score only in the nifedipine group. The mean WSRS score at T0 was 3.85 and at T3 1.84 in the nifedipine group, while the mean WSRS score at T0 was 3.78 and at T3 3.36 in the control group. Corneometry showed significant increases in measures of skin hydration and TEWL values decreased in all the patients of both groups, indicating a trend toward improved integrity of skin. Dermolab® recorded significant increases in measures of skin hydration in the nifedipine group and a lower increase in the control group. The colorimetric evaluation showed that use of the tested product resulted in significant overall lightening of the skin during use compared with baseline, while the moisturizer didn't produce any change of skin lightening parameters.
  
  
  CONCLUSIONS
  The tested topical preparation is effective in reducing facial wrinkles' depth and in increasing skin hydration and elasticity.
authors.affiliation: Department of Dermatology, University of Naples Federico II , Naples , Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Calabrò
authors.forename: Valerio
authors.initials: V
authors.lastname: De Vita
authors.forename: Angela
authors.initials: A
authors.lastname: Patalano
authors.forename: Caterina
authors.initials: C
authors.lastname: Mazzella
authors.forename: Viviana
authors.initials: V
authors.lastname: Lo Conte
authors.forename: Carmine
authors.initials: C
authors.lastname: Antropoli
mesh_terms: D000287:Administration, Topical; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005145:Face; D005260:Female; D006801:Humans; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage*; D016037:Single-Blind Method; D012867:Skin / Q000187:drug effects*; D015595:Skin Aging / Q000187:drug effects*; D063465:Skin Cream / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D002121:Calcium Channel Blockers; D003879:Dermatologic Agents; D009543:Nifedipine