title: Promoters of cancer genes for recombinant protein expression in human cancer cell lines.
abstract: BACKGROUND
  Production of complex human recombinant proteins is an important issue in medical biotechnology. These proteins are mostly expressed in non-human mammalian host cells. This has some problems including non-human post-translational modifications, application of high-cost agents for inducing protein expression and low yields. Thus, it is necessary to use new expression systems to overcome the indicated challenges.
  
  
  METHODS
  In this paper, we hypothesize the application of promoter regions of cancer genes, which have a high rate of transcription in human cancer cell lines, for designing new expression vectors.
  
  
  RESULTS
  After designing, these vectors could be applied to produce complex hu-man recombinant proteins in the human cancer cell lines as production hosts.
  
  
  CONCLUSIONS
  Application of these expression vectors for the production of recombinant human proteins in the human cancer cell lines have some advantages including authentic post-translational modifications, proper-cost of commercialization, and high yields.
authors.affiliation: Department of Medical Biotechnology, School of Advanced Biomedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran ; Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran ; Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Pourhassan-Moghaddam
authors.forename: Behrouz
authors.initials: B
authors.lastname: Farhadi
authors.forename: Kazem
authors.initials: K
authors.lastname: Nejati-Koshki
authors.forename: Tamouchin
authors.initials: T
authors.lastname: Moharrami
keywords: Cancer Genes; Human Cancer Cell Lines; Promoters; Recombinant Protein Expression