title: Synthesis of densely functionalized 3a,4-dihydro-1H-pyrrolo[1,2-b]pyrazoles via base mediated domino reaction of vinyl malononitriles with 1,2-diaza-1,3-dienes.
abstract: A domino reaction of vinyl malononitriles (VMs) with 1,2-diaza-1,3-dienes (DDs) produce unprecedented 3a,4-dihydro-1H-pyrrolo[1,2-b]pyrazole systems in a chemo-, regio-, and stereoselective fashion. This base promoted (DIPEA) one-pot transformation involving multiple steps constructs one new C-C bond, two C-N bonds, and two new fused heterocyclic rings with total atom economy.
authors.affiliation: Department of Biomolecular Sciences, Section of Organic Chemistry and Organic Natural Compounds, University of Urbino Carlo Bo, Via I Maggetti 24, 61029 Urbino (PU), Italy.
authors.forename: Orazio A
authors.initials: OA
authors.lastname: Attanasi
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Favi
authors.forename: Athina
authors.initials: A
authors.lastname: Geronikaki
authors.forename: Fabio
authors.initials: F
authors.lastname: Mantellini
authors.forename: Giada
authors.initials: G
authors.lastname: Moscatelli
authors.forename: Aliki
authors.initials: A
authors.lastname: Paparisva
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D018360:Crystallography, X-Ray; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D009570:Nitriles; D011720:Pyrazoles; D014753:Vinyl Compounds; C000945:dicyanmethane