title: The antiviral activities of tetherin.
abstract: Tetherin (BST2/CD317) has emerged as a key host cell defense molecule, inhibiting the release and spread of diverse enveloped virions from infected cells. In this chapter, I review the molecular and cellular basis for tetherin's antiviral activities and the function of virally encoded countermeasures that disrupt its function. I further describe recent advances in our understanding of tetherin's associated role in viral pattern recognition and the evidence for its role in limiting viral pathogenesis in vivo.
authors.affiliation: Department of Infectious Disease, King's College London School of Medicine, London, UK. stuart.neil@kcl.ac.uk
authors.forename: Stuart J D
authors.initials: SJ
authors.lastname: Neil
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D058851:GPI-Linked Proteins / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D014780:Viruses / Q000276:immunology*; D000074010:Bone Marrow Stromal Antigen 2
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2