title: Comparative evaluation of 3-dimensional pseudocontinuous arterial spin labeling with dynamic contrast-enhanced perfusion magnetic resonance imaging in grading of human glioma.
abstract: BACKGROUND
  The study was performed to compare dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) with 3-dimensional (3D) pseudocontinuous arterial spin labeling (PCASL) MRI in gliomas with an aim to see whether arterial spin labeling (ASL)-derived cerebral blood flow (CBF) values can be used as an alternative to DCE-MRI for its grading.
  
  
  METHODS
  Sixty-four patients with glioma (37 male; mean age, 43 years; 38 high grade and 26 low grade) underwent 3D-PCASL and DCE-MRI. The DCE indices (relative cerebral blood volume, rCBV; relative CBF, rCBF; permeability, k and kep; and leakage, ve) and ASL (absolute and rCBF) values were quantified from the tumors. Student independent t test was used to compare ASL and DCE-MRI indices. Pearson correlation was used to see correlation between DCE- and ASL-derived CBF values in tumor and normal parenchyma.
  
  
  RESULTS
  On Student t test, neither ASL-derived absolute CBF (P = 0.78) nor rCBF (P = 0.12) values were found to be significantly different in 2 groups, whereas DCE indices except ve were significantly higher in high-grade gliomas. Arterial spin labeling-derived rCBF values weakly correlated with DCE-derived rCBF values, whereas these did not show correlation in normal grey (P = 0.12, r = 0.2) and white (P = 0.26, r = 0.14) matter regions.
  
  
  CONCLUSIONS
  Three-dimensional pseudocontinuous arterial spin labeling does not appear to be a reliable technique in the current form and may not be a suitable replacement for DCE in grading of glioma.
authors.affiliation: Departments of Radiology & Imaging, Fortis Memorial Research Institute, Gurgaon, India.
authors.forename: Bhaswati
authors.initials: B
authors.lastname: Roy
authors.forename: Rishi
authors.initials: R
authors.lastname: Awasthi
authors.forename: Amit
authors.initials: A
authors.lastname: Bindal
authors.forename: Prativa
authors.initials: P
authors.lastname: Sahoo
authors.forename: Rajan
authors.initials: R
authors.lastname: Kumar
authors.forename: Sanjay
authors.initials: S
authors.lastname: Behari
authors.forename: Bal K
authors.initials: BK
authors.lastname: Ojha
authors.forename: Nuzhat
authors.initials: N
authors.lastname: Husain
authors.forename: Chandra M
authors.initials: CM
authors.lastname: Pandey
authors.forename: Ram K S
authors.initials: RK
authors.lastname: Rathore
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Gupta
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology*; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D005260:Female; D005910:Glioma / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D060787:Neoplasm Grading; D013113:Spin Labels
chemical_list: D003287:Contrast Media; D013113:Spin Labels