title: Impact of low- or high-flux haemodialysis and online haemodiafiltration on inflammatory markers and lipid profile in chronic haemodialysis patients.
abstract: OBJECTIVE
  We aimed to evaluate the impact of low- or high-flux haemodialysis (HD) and online haemodiafiltration (OL-HDF) on inflammation and the lipid profile in HD patients.
  
  
  METHODS
  50 HD patients were assigned to two groups for HD with low-flux (n = 25) or high-flux (n = 25) polysulphone dialysers for 6 weeks. Subsequently, all patients were haemodialysed with a low-flux polysulphone dialyser for 6 weeks, then transferred to OL-HDF for another 6 weeks. Blood samples for lipids and inflammatory markers (IL-6, IL-8, TNF-α, hs-CRP) were obtained at baseline and every 6 weeks.
  
  
  RESULTS
  Changes in inflammatory markers and lipids from baseline to the 6-week dialysis period did not differ between low- and high-flux groups. When patients were transferred from low-flux HD to OL-HDF, IL-6, IL-8, and TNF-α levels significantly decreased whereas HDL and LDL cholesterol significantly increased.
  
  
  CONCLUSIONS
  Low- and high-flux polysulphone membranes had similar effects on lipids and inflammatory markers, whereas OL-HDF potently reduced pro-inflammatory cytokines.
authors.affiliation: Department of Nephrology, Ankara Numune Research and Education Hospital, Ankara, Turkey. drakomd@yahoo.com
authors.forename: Hadim
authors.initials: H
authors.lastname: Akoglu
authors.forename: Fatih
authors.initials: F
authors.lastname: Dede
authors.forename: Serhan
authors.initials: S
authors.lastname: Piskinpasa
authors.forename: Mesude Y
authors.initials: MY
authors.lastname: Falay
authors.forename: Ali Riza
authors.initials: AR
authors.lastname: Odabas
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016207:Cytokines / Q000097:blood*; D005260:Female; D017583:Hemodiafiltration; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000628:therapy; D018836:Inflammation Mediators / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011108:Polymers; D013450:Sulfones
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators; D008055:Lipids; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D002097:C-Reactive Protein