title: Rosa canina L. Fruit Hydro-Alcoholic Extract Effects on Some Immunological and Biochemical Parameters in Rats.
abstract: BACKGROUND
  This research investigates the possible potential of Rosa canina (RC) as an immunomodulator in rats and its effects on some biochemical parameters.
  
  
  METHODS
  In this experiment, 45 male Wistar rats were obtained and divided into three groups (n = 15). These groups received normal saline (10 mg/kg), RC fruit extract (250 mg/kg) and RC fruit extract (500 mg/kg) as oral gavages every day for a period of four weeks, respective-ly. After obtaining blood samples (at the end of each week), differential white blood cell (WBC) counts, phagocyte activity (number), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP) albumin and globulins levels of sam-ples were obtained. The malondialdehyde (MDA) and glutathione (GSH) levels in the se-rum were determined only in day 28 of study. The radical scavenger activity (RSA) of the RC extract was measured spectrophotometrically.
  
  
  RESULTS
  the gamma globulin level, neu-trophil and monocyte counts and phagocyte activity increased significantly in comparison with the normal saline group. ALT, AST and ALP had not significantly differences in compared to control group. RC extract significantly increased thiobarbituric acid reactive substances (TBARS) and also decreased GSH levels in comparing to control group in day 28.
  
  
  CONCLUSIONS
  the data suggest that the RC extract has been used in traditional medicine might have immunomodulatory effects.
authors.affiliation: Department of Molecular Neurobiology, Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Sadigh-Eteghad
authors.forename: Hossein
authors.initials: H
authors.lastname: Tayefi-Nasrabadi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Aghdam
authors.forename: Habib
authors.initials: H
authors.lastname: Zarredar
authors.forename: Dariush
authors.initials: D
authors.lastname: Shanehbandi
authors.forename: Leila
authors.initials: L
authors.lastname: Khayyat
authors.forename: Seyyed-Hamed
authors.initials: SH
authors.lastname: Seyyed-Piran
keywords: Biochemical Parameters; Immunological Parameters; Rats; Rosa canina