title: A facile synthesis, anti-inflammatory and analgesic activity of isoxazolyl-2,3-dihydrospiro[benzo[f]isoindole-1,3'-indoline]-2',4,9-triones.
abstract: A new series of isoxazolyl-2,3-dihydrospiro[benzo[f]isoindole-1,3'-indoline]-2',4,9-triones (14) were synthesized by reaction of 4-amino-3-methyl-5-styrylisoxazole 10 with chloroacetic acid followed by a three component reaction with substituted isatins 12 and 1,4-naphthoquinone 13 using Ceric ammonium nitrate (CAN) catalyst under aerial oxidation condition. Structures of these compounds were established on the basis of IR, (1)H NMR, (13)C NMR and mass spectral data. The title compounds 14a-j were evaluated for their anti-inflammatory and analgesic activity. Compounds 14d, 14e and 14f exhibited potent anti-inflammatory and analgesic activity as that of standard drugs.
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal, 506 009 AP, India. rajanarendareligeti@gmail.com
authors.forename: E
authors.initials: E
authors.lastname: Rajanarendar
authors.forename: S
authors.initials: S
authors.lastname: Ramakrishna
authors.forename: K
authors.initials: K
authors.lastname: Govardhan Reddy
authors.forename: D
authors.initials: D
authors.lastname: Nagaraju
authors.forename: Y N
authors.initials: YN
authors.lastname: Reddy
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D054833:Isoindoles / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D007555:Isoxazoles / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male; D008968:Molecular Conformation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D054833:Isoindoles; D007555:Isoxazoles; D002351:Carrageenan