title: Intravenous human umbilical cord blood improves electrophysiological and metabolic properties in ISO induced myocardial necrosis in rats.
abstract: Rats treated with isoproterenol (ISO, 85 mg/kg, sc, twice at an interval of 24 h) showed a significant increase in heart rate, mean arterial blood pressure, pressure rate index, ST elevation on ECG, and a significant increase in the levels of cardiac marker enzymes- lactate dehydrogenase, and creatine kinase in serum and a significant reduction in superoxide dismutase, and catalase and increase in thiobarbituric acid reactive substance activity in heart tissue. Treatment with Human umbilical cord blood (hUCBC; 500 and 1000 microL, iv, via the tail vein; 2 h after the second dose of ISO) significantly restored back to normal levels and showed a lesser degree of cellular infiltration and infarct size in histopathological and planimetry studies respectively. Thus, hUCBC ameliorates cardiotoxic effects of isoproterenol and may be of value in the treatment of myocardial infarction.
authors.affiliation: Department of Pharmacology, M.G.V's Pharmacy College, Nashik, Maharashtra, India. mm_nasik@yahoo.co.in
authors.forename: Mahalaxmi
authors.initials: M
authors.lastname: Mohan
authors.forename: Rahul
authors.initials: R
authors.lastname: Rokade
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kasturet
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D054715:Cardiotoxins / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D004594:Electrophysiology / Q000379:methods*; D005312:Fetal Blood / Q000166:cytology*; D006339:Heart Rate; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D009336:Necrosis / Q000473:pathology / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D000975:Antioxidants; D054715:Cardiotoxins; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D007545:Isoproterenol