title: Genetic studies of IgA nephropathy: what have we learned from genome-wide association studies.
abstract: Primary IgA nephropathy (IgAN) is the most common glomerulonephritis in the world. It is most common in Asian populations, followed by Caucasians, yet relatively infrequent amongst African populations. The striking difference in the prevalence of IgAN between world populations, together with the known familial aggregation of disease, suggests an inherited mechanism. Recently three genome-wide association studies (GWAS) of IgAN have identified seven susceptibility loci, providing initial insight into the genetic architecture of this trait. While genetic studies of complex traits are challenging, applying new techniques and methods of analysis, especially Next-Generation Sequencing, will push the genetic studies of IgAN forward.
authors.affiliation: Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, PR China.
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Xie
authors.forename: Samantha
authors.initials: S
authors.lastname: Shapiro
authors.forename: Ali
authors.initials: A
authors.lastname: Gharavi
mesh_terms: D017242:Complement Factor H / Q000235:genetics; D055106:Genome-Wide Association Study; D005922:Glomerulonephritis, IGA / Q000209:etiology / Q000235:genetics*; D059868:HLA-DP beta-Chains / Q000235:genetics; D059811:HLA-DRB1 Chains / Q000235:genetics; D006801:Humans; D054558:Protein Tyrosine Phosphatases, Non-Receptor / Q000235:genetics; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000235:genetics; D023084:alpha-Defensins / Q000235:genetics
chemical_list: D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D059811:HLA-DRB1 Chains; C114631:TNFSF13 protein, human; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13; D023084:alpha-Defensins; D017242:Complement Factor H; C444436:MTMR3 protein, human; D054558:Protein Tyrosine Phosphatases, Non-Receptor