title: Resequencing and association analysis of MIR137 with schizophrenia in a Japanese population.
abstract: MicroRNA may play a role in the pathophysiology of schizophrenia. A recent meta-analysis of genome-wide association studies indicated a significant association between schizophrenia and a common intronic variation in MIR137HG (microRNA 137 host gene) encoding the primary microRNA-137. To explore additional risk variations for schizophrenia, we resequenced MIR137 and performed an association analysis in 1321 Japanese individuals. By resequencing, we detected four sequence variations in the 5' and 3' flanking regions. There were no significant associations between these variations and schizophrenia. Our resequencing and association analysis of MIR137 failed to find additional risk variations for schizophrenia.
authors.affiliation: Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Egawa
authors.forename: Ayako
authors.initials: A
authors.lastname: Nunokawa
authors.forename: Masako
authors.initials: M
authors.lastname: Shibuya
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Naoshi
authors.initials: N
authors.lastname: Kaneko
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Igeta
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Someya
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007564:Japan; D035683:MicroRNAs / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C545567:MIRN137 microRNA, human; D035683:MicroRNAs