title: Detection of genetic translocations in lymphoma using fluorescence in situ hybridization.
abstract: Certain lymphoma types are characterized by recurring genetic translocations. Detection of these translocations enables confirmation of a suspected diagnosis and provides a genetic marker which can be subsequently monitored and followed. Rapid and reliable identification of these molecular rearrangements is a key component in the workup of lymphoma. While conventional cytogenetics may be a useful tool in this regard, fluorescence in situ hybridization (FISH) offers additional advantages including the ability to use formalin-fixed tissues, no requirement for dividing cells, ability to score many cells, improved sensitivity, and faster turnaround time for results.
authors.affiliation: Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic Rochester, Rochester, MN, USA.
authors.forename: Kaaren K
authors.initials: KK
authors.lastname: Reichard
authors.forename: Sheldon
authors.initials: S
authors.lastname: Robinett
mesh_terms: D003582:Cytogenetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D008223:Lymphoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics*