title: Research on hereditability of gastric cancer in wuwei city.
abstract: OBJECTIVE
  To explore hereditability of gastric cancer in Wuwei city.
  
  
  METHODS
  A case-control study was used to investigate 251 gastric cancer families located in Wuwei city. Li-Mantel-Gan and Falconer regression methods were used to calculate segregation ratios and hereditability.
  
  
  RESULTS
  The segregation ratio in Wuwei families was 0.0774, the hereditability of class I kinfolks and class II kinfolks were respectively 22.91% and 20.07%.
  
  
  CONCLUSIONS
  The segregation ratio of gastric cancer in Wuwei was significantly lower than for mono-genetic diseases (0.25), corresponding better with a model of polygenetic diseases. The genetic susceptibility factor accounted for about 1/5-1/4 in the formation of gastric cancer familial aggregation. Mi DH, Chen XP, Luo HZ Research on hereditability of gastric cancer in Wuwei city.
authors.affiliation: Gansu Wuwei Tumor Hospital, Wuwei, Gansu Province, China.
authors.forename: Deng-Hai
authors.initials: DH
authors.lastname: Mi
authors.forename: Xue-Peng
authors.initials: XP
authors.lastname: Chen
authors.forename: Hao-Zeng
authors.initials: HZ
authors.lastname: Luo
keywords: gastric cancer; hereditability