title: Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination.
abstract: Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies: one or several round basophilic structures of approximately 1 to 10 µm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia.
authors.affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Go Eun
authors.initials: GE
authors.lastname: Bae
authors.forename: Nara
authors.initials: N
authors.lastname: Yoon
authors.forename: Ha Young
authors.initials: HY
authors.lastname: Park
authors.forename: Sang Yun
authors.initials: SY
authors.lastname: Ha
authors.forename: Junhun
authors.initials: J
authors.lastname: Cho
authors.forename: Yunkyung
authors.initials: Y
authors.lastname: Lee
authors.forename: Kyoung-Mee
authors.initials: KM
authors.lastname: Kim
authors.forename: Cheol Keun
authors.initials: CK
authors.lastname: Park
keywords: Colon; Kidney transplantation; Malakoplakia