title: Pulse radiolysis studies on the reaction of the reduced vitamin B₁₂ complex Cob(II)alamin with superoxide.
abstract: O₂.- scavenger: The rate constant for the rapid reaction of the ROS superoxide with the reduced vitamin B₁₂ radical complex cob(II)alamin was directly determined to be 3.8×10(8) M⁻¹ s⁻¹. This rate was independent of pH over the range 5.5-8.7. These results have implications for studying the use of B₁₂ supplements to combat diseases associated with oxidative stress.
authors.affiliation: Department of Chemistry & Biochemistry and School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA.
authors.forename: Rohan S
authors.initials: RS
authors.lastname: Dassanayake
authors.forename: Diane E
authors.initials: DE
authors.lastname: Cabelli
authors.forename: Nicola E
authors.initials: NE
authors.lastname: Brasch
mesh_terms: D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010084:Oxidation-Reduction; D013481:Superoxides / Q000737:chemistry*; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D013481:Superoxides; C097751:cob(II)alamin; D014805:Vitamin B 12