title: Cardiorenal syndrome type 5: clinical presentation, pathophysiology and management strategies from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI).
abstract: Cardiorenal syndrome type 5 (CRS-5) includes conditions where there is a simultaneous involvement of the heart and kidney from a systemic disorder. Given the wide spectrum of diseases that contribute to CRS-5, several pathophysiological mechanisms are invoked representing the response of the heart and kidney to the contributing disorder that is ongoing. The nature, duration and the underlying condition of the heart and kidney strongly influence the clinical course of CRS-5. In this paper we discuss the pathophysiology of CRS-5 in the setting of sepsis as a model system for CRS-5 providing a brief overview of strategies for monitoring and therapeutic intervention. We offer a framework for reference for considering other disorders leading to CRS-5 where the development of cardiac and renal dysfunction is more insidious.
authors.affiliation: Department of Medicine, University of California San Diego, San Diego, CA 92103 , USA. rmehta@ucsd.edu
authors.forename: Ravindra L
authors.initials: RL
authors.lastname: Mehta
authors.forename: Hamid
authors.initials: H
authors.lastname: Rabb
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Shaw
authors.forename: Kai
authors.initials: K
authors.lastname: Singbartl
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
authors.forename: Peter A
authors.initials: PA
authors.lastname: McCullough
authors.forename: John A
authors.initials: JA
authors.lastname: Kellum
mesh_terms: D059347:Cardio-Renal Syndrome / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D006321:Heart / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D006435:Renal Dialysis / Q000592:standards*; D012084:Renin-Angiotensin System / Q000502:physiology; D018805:Sepsis / Q000150:complications