title: Therapeutic potential of curcumin in experimentally induced allergic rhinitis in guinea pigs.
abstract: In the present experiments, the possible role of curcumin in ovalbumin induced allergic rhinitis in guinea pig model was investigated. Various allergic rhinitis symptoms viz sneezing, rubbing frequencies, lacrimation and nasal congestion at various humidity conditions as well as on repeated sensitization were studied. The biochemical changes like serum IgE, IL-4 and nitric oxide (NO) in nasal lavage and eosinophil peroxidase activity in nasal homogenates were determined in allergic rhinitis. Curcumin treatment significantly reduced the symptoms (sneezing, rubbing frequencies, lacrimation and nasal congestion) and improved the histopathological alterations (reduction in inflammatory cells infiltration) of nasal mucosa in allergic rhinitis. Furthermore, curcumin treatment prevented significantly elevation of serum IgE, IL-4, NO in nasal lavage and eosinophil peroxidase in nasal homogenate. In the present experimental findings, we suggest that curcumin is a promising anti-allergic agent that may be useful in the clinical management of allergic rhinitis.
authors.affiliation: Department of Pharmacology, Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Maharashtra, 410401, India.
authors.forename: Vishnu N
authors.initials: VN
authors.lastname: Thakare
authors.forename: M M
authors.initials: MM
authors.lastname: Osama
authors.forename: Suresh R
authors.initials: SR
authors.lastname: Naik
mesh_terms: D000085:Acetates / Q000627:therapeutic use; D000818:Animals; D004205:Cromolyn Sodium / Q000494:pharmacology; D003474:Curcumin / Q000008:administration & dosage / Q000627:therapeutic use*; D003521:Cyclopropanes; D004305:Dose-Response Relationship, Drug; D047209:Eosinophil Peroxidase / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D006168:Guinea Pigs; D006813:Humidity; D015847:Interleukin-4 / Q000235:genetics / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide; D010047:Ovalbumin / Q000276:immunology*; D011804:Quinolines / Q000627:therapeutic use; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000139:chemically induced* / Q000188:drug therapy; D013440:Sulfides
chemical_list: D000085:Acetates; D003521:Cyclopropanes; D011804:Quinolines; D013440:Sulfides; D015847:Interleukin-4; D009569:Nitric Oxide; D010047:Ovalbumin; D047209:Eosinophil Peroxidase; D003474:Curcumin; C093875:montelukast; D004205:Cromolyn Sodium
keywords: Allergic rhinitis; Biochemical alterations; Curcumin; Guinea pig model