title: Lipid peroxidation in Nigerians affected with haematological malignancies.
abstract: This study investigated Lipid peroxidation status in twenty Nigerians; five (5) healthy subjects and 15 (fifteen) Haematological cancer patients; 5 affected with Chronic Myeloid leukaemia (CML), 5 (five) with Non-Hodgkin's Lymphoma and 5 (five) with Multiple Myeloma. Consents were sought and received from all participants used in the study. 10 mls of blood samples were collected in lithium heparin bottles from all subjects used in the study. Free plasma Malondialdehyde (MDA) quantification was used to assess lipid peroxidation in all subjects. MDA levels were increased in CML and Non-Hodgkin Lymphoma patients compared with that of control subjects at P < 0.001. However, a decreased non-significant free plasma MDA level was observed in multiple myeloma patients compared with control subjects. Increase in lipid peroxidation status in Nigerians affected with Haematological malignancies may be associated with a dysregulation of antioxidant system. Lipid peroxidation status could be used as clinical clue for diagnosis, prognosis and treatment of patients affected with haematological malignancies.
authors.affiliation: Department of Anatomy, University of Ilorin, Ilorin, Kwara State, Nigeria. a3laja@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Akinlolu
authors.forename: T
authors.initials: T
authors.lastname: Akingbola
authors.forename: B
authors.initials: B
authors.lastname: Salau
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000378:metabolism; D015227:Lipid Peroxidation; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood* / Q000378:metabolism; D009101:Multiple Myeloma / Q000175:diagnosis / Q000378:metabolism; D009549:Nigeria; D018384:Oxidative Stress; D011379:Prognosis
chemical_list: D008315:Malondialdehyde