title: Primary pulmonary adenocarcinoma mimicking papillary thyroid carcinoma.
abstract: We herein reported a primary pulmonary papillary carcinoma with colloid-like luminal content in the glandular cavity and classic nuclear features such as pseudo-inclusions, intranuclear grooves in the tumor cell nuclei and ground glass nuclei which closely mimics papillary thyroid carcinoma. Meanwhile, lymph node in the left pulmonary hilum was involved and showed similar features to the primary pulmonary papillary carcinoma. This specific histopathological presentation caused a diagnostic dilemma.The patient didn't show previous concomitant or subsequent evidence of a thyroid tumor. Immunohistochemistry further confirmed pulmonary origin and excluded a metastasis from the thyroid, as it was thyroglobulin negative, thyroid transcription factor 1 and surfactant apoprotein A positive, which was consistent with the imageology and history.Based on the above features, the diagnosis of primary pulmonary papillary carcinoma was confirmed. Understanding the existence of papillary thyroid carcinoma-like pulmonary papillary carcinoma will avoid misdiagnosis or unnecessary clinical and radiologic investigations in future.
authors.affiliation: Department of Pathology, Guangdong provincial hospital of TCM, Guangzhou, University of Chinese medicine, Guangzhou, China. yayazhu2010@foxmail.com
authors.forename: Ya-Zhen
authors.initials: YZ
authors.lastname: Zhu
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Li
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Wang
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Yang
authors.forename: Qing-Lian
authors.initials: QL
authors.lastname: He
authors.forename: Hong-Guang
authors.initials: HG
authors.lastname: Zhu
authors.forename: Guang-Juan
authors.initials: GJ
authors.lastname: Zheng
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D000369:Aged, 80 and over; D002277:Carcinoma / Q000000981:diagnostic imaging; D002291:Carcinoma, Papillary; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D061865:Hemorrhoidectomy; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D008197:Lymph Node Excision; D008297:Male; D011013:Pneumonectomy; D011859:Radiography; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging; D014463:Ultrasonography