title: A rare case with typical acute promyelocytic leukemia morphology associated with isolated isochromosome 17q without RARα rearrangement.
abstract: Isolated isochromosome 17q has rarely been reported in hematologic tumor patients. A 37-year-old man was admitted with fever and weakness. Blood routine test showed anemia and thrombocytopenia. The morphology and immunology of bone marrow cells conform to classic acute promyelocytic leukemia (APL). But the karyotype showed isolated isochromosome 17q without t(15;17) (q22;q12). Rverse transcriptase polymerase chain reaction (RT-PCR) for PML -RARa was negative and fluorescence in situ hybridization (FISH) analysis showed no RARa gene rearrangements.The patient responded poorly to all trans retinoic acid and traditional chemotherapy with daunorubicin and cytarabine and survived only 43 days after diagnosis. The pathogenesis and the best treatment choice for this kind of patients are not clear currently.
authors.affiliation: Affiliated Hospital of Taishan Medical University, Taian, Shandong, China. duansuper@yahoo.cn
authors.forename: Yanchao
authors.initials: Y
authors.lastname: Duan
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Hongbo
authors.initials: H
authors.lastname: Zhu
authors.forename: Wenqing
authors.initials: W
authors.lastname: Shang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002886:Chromosomes, Human, Pair 17; D003561:Cytarabine / Q000627:therapeutic use; D003630:Daunorubicin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018404:Isochromosomes; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D018168:Receptors, Retinoic Acid / Q000235:genetics*; D000072482:Retinoic Acid Receptor alpha
chemical_list: D000903:Antibiotics, Antineoplastic; C000607071:RARA protein, human; D018168:Receptors, Retinoic Acid; D000072482:Retinoic Acid Receptor alpha; D003561:Cytarabine; D003630:Daunorubicin