title: NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound.
abstract: Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of (195)Pt and (15)N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.
authors.affiliation: Institute for Glycomics, Griffith University, Gold Coast Campus, QLD 4222, Australia.
authors.forename: Louise E
authors.initials: LE
authors.lastname: Wedlock
authors.forename: Matt R
authors.initials: MR
authors.lastname: Kilburn
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: Shaw
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Berners-Price
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Farrell
mesh_terms: D000588:Amines / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D036103:Nanotechnology; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology; D018629:Spectrometry, Mass, Secondary Ion; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds