title: The role of arginine methylation in the DNA damage response.
abstract: Post-translational modifications are well-known modulators of DNA damage signaling and epigenetic gene expression. Protein arginine methylation is a covalent modification that results in the addition of methyl groups to the nitrogen atoms of the arginine side chains and is catalyzed by a family of protein arginine methyltransferases (PRMTs). In the past, arginine methylation was mainly observed on abundant proteins such as RNA-binding proteins and histones, but recent advances have revealed a plethora of arginine methylated proteins implicated in a variety of cellular processes including RNA metabolism, epigenetic regulation and DNA repair pathways. Herein, we discuss these recent advances, focusing on the role of PRMTs in DNA damage signaling and its importance for maintaining genomic stability.
authors.affiliation: Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Segal Cancer Centre, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Departments of Oncology and Medicine, McGill University, Montréal, Québec H3T 1E2, Canada.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Auclair
authors.forename: Stéphane
authors.initials: S
authors.lastname: Richard
mesh_terms: D000818:Animals; D001120:Arginine / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D008745:Methylation; D011499:Protein Processing, Post-Translational
chemical_list: D001120:Arginine