title: Evaluation of bioactivities of chlorokojic acid derivatives against dermatophytes couplet with cytotoxicity.
abstract: In an attempt to find novel antifungal agents with improved activity, a series of compounds bearing 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one moiety were synthesized and examined for their cytotoxic evaluation and antifungal activities against both standard and isolated dermatophytic fungal species Microsporum gypseum, Trichophyton mentagrophytes var. erinacei and Epidermophyton floccosum.
authors.affiliation: Dept. Pharm. Chem., Fac. Pharm., Hacettepe University, 06100 Ankara, Turkey. mutlud@hacettepe.edu.tr
authors.forename: Mutlu Dilsiz
authors.initials: MD
authors.lastname: Aytemir
authors.forename: Berrin
authors.initials: B
authors.lastname: Ozçelik
authors.forename: Gülşah
authors.initials: G
authors.lastname: Karakaya
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects* / Q000302:isolation & purification; D011753:Pyrones / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D011753:Pyrones; C116986:2-chloromethyl-5-hydroxy-4-pyranone