title: The cost effectiveness of early management of acute appendicitis underlies the importance of curative surgical services to a primary healthcare programme.
abstract: BACKGROUND
  Appendicitis in the developing world is a cause of significant preventable morbidity. This prospective study from a regional hospital in South Africa constructs a robust cost model that demonstrates the cost effectiveness of an efficient curative surgical service in a primary healthcare-orientated system.
  
  
  METHODS
  A prospective audit of all patients with acute appendicitis admitted to Edendale Hospital was undertaken from September 2010 to September 2011. A microcosting approach was used to construct a cost model based on the estimated cost of operative and perioperative interventions together with the associated hospital stay. For cost analysis, patients were divided into the following cohorts: uncomplicated appendicitis, complicated appendicitis with localised intra-abdominal sepsis, complicated appendicitis with generalised intra-abdominal sepsis, with and without intensive care unit admission.
  
  
  RESULTS
  Two hundred patients were operated on for acute appendicitis. Of these, 36% (71/200) had uncomplicated appendicitis and 57% (114/200) had perforation. Pathologies other than appendicitis were present in 8% (15/200) and these patients were excluded. Of the perforated appendices, 45% (51/114) had intra-abdominal contamination that was localised while 55% (63/114) generalised sepsis. The mean cost for each patient was: 6,578 ZAR (£566) for uncomplicated appendicitis; 14,791 ZAR (£1,272) for perforation with localised intra-abdominal sepsis and 34,773 ZAR (£2,990) for perforation with generalised intra-abdominal sepsis without intensive care admission. With intensive care admission it was 77,816 ZAR (£6,692). The total cost of managing acute appendicitis was 4,272,871 ZAR (£367,467). Almost 90% of this total cost was owing to advanced disease with abdominal sepsis and therefore potentially preventable.
  
  
  CONCLUSIONS
  Early uncomplicated appendicitis treated appropriately carries little morbidity and is relatively inexpensive to treat. As the pathology progresses, the cost rises exponentially. An efficient curative surgical service must be regarded as a cost effective component of a primary healthcare orientated system.
authors.affiliation: University of KwaZulu-Natal, South Africa. victorywkong@yahoo.com
authors.forename: V
authors.initials: V
authors.lastname: Kong
authors.forename: C
authors.initials: C
authors.lastname: Aldous
authors.forename: J
authors.initials: J
authors.lastname: Handley
authors.forename: D
authors.initials: D
authors.lastname: Clarke
mesh_terms: D000208:Acute Disease; D019072:Antibiotic Prophylaxis / Q000191:economics; D001062:Appendectomy / Q000191:economics / Q000379:methods; D001064:Appendicitis / Q000191:economics* / Q000601:surgery; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D011446:Prospective Studies; D055815:Young Adult