title: Efficient catalysts for asymmetric Mannich reactions.
abstract: Efficient chiral catalysts for direct asymmetric three-component Mannich reactions of ketones, aldehydes and an amine (p-anisidine) have been developed. The corresponding β-amino carbonyl compounds (Mannich adducts) were obtained in good chemical yields and excellent enantio- and diastereoselectivities. The reaction conditions have been optimized by invoking ultrasonication and the influence of some structural moieties of the catalysts on the chemical yield and stereoselectivity of the Mannich products has been evaluated.
authors.affiliation: Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. m.rachwalski@science.ru.nl
authors.forename: Michał
authors.initials: M
authors.lastname: Rachwalski
authors.forename: Tim
authors.initials: T
authors.lastname: Leenders
authors.forename: Sylwia
authors.initials: S
authors.lastname: Kaczmarczyk
authors.forename: Piotr
authors.initials: P
authors.lastname: Kiełbasiński
authors.forename: Stanisław
authors.initials: S
authors.lastname: Leśniak
authors.forename: Floris P J T
authors.initials: FP
authors.lastname: Rutjes
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000814:Aniline Compounds; D007659:Ketones; C013813:4-anisidine