title: [Twin pregnancy discordant for trisomy 13: three cases].
abstract: BACKGROUND
  The association between Patau's syndrome and multiple pregnancy is extremely rare. This paper reports three cases with different obstetric treatment. CASE 1: Dichorionic diamniotic twin pregnancy with a fetus affected by trisomy 13 diagnosed at 16 weeks of gestation. The pregnancy was managed conservatively resulting in the delivery of twins at 38 weeks. The structurally normal twin was male survived without sequelae, but the female fetus with trisomy 13 died shortly after delivery. CASE 2: Dichorionic diamniotic twin pregnancy. At 14 weeks of pregnancy, one of the fetus affected by trisomy 13 showed an early intrauterine growth restriction and a cystic hygroma. At 16 weeks of pregnancy the abnormal twin died spontaneously. Avaginal delivery occurred at 38 weeks being born a healthy male. CASE 3: Dichorionic diamniotic twin pregnancy. The trisomy 13 fetus had been diagnosed at 17 weeks of pregnancy and showed a cardiopathy. At 32 weeks of gestation a selective fetal reduction was performed. Vaginal delivery occurred at 35 weeks and a healthy newborn was born.
  
  
  CONCLUSIONS
  Patau's syndrome has an unfortunate fetal and neonatal outcome. It is important an early diagnosis to establish the best strategy to minimize the risk of the healthy twin.
authors.affiliation: Servicio de Obstetricia, Hospital Universitario La Paz, Madrid, España.
authors.forename: Nuria
authors.initials: N
authors.lastname: López-Velasco
authors.forename: Laura
authors.initials: L
authors.lastname: Sotillo-Mallo
authors.forename: Begoña
authors.initials: B
authors.lastname: Martínez-Montoro
authors.forename: María de la Calle
authors.initials: Mde L
authors.lastname: Fernández-Miranda
mesh_terms: D000328:Adult; D025063:Chromosome Disorders / Q000000981:diagnostic imaging / Q000628:therapy; D002882:Chromosomes, Human, Pair 13 / Q000000981:diagnostic imaging; D004200:Diseases in Twins / Q000000981:diagnostic imaging / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D014314:Trisomy; D000073839:Trisomy 13 Syndrome; D016216:Ultrasonography, Prenatal