title: Preparation of electrospun fiber mats using siloxane-containing vaterite and biodegradable polymer hybrids for bone regeneration.
abstract: An electrospun fiber mat using a new composite consisting of siloxane-containing vaterite (SiV) and poly(lactic-co-glycolic acid) (PLGA) (denoted by SiPLGVH) was prepared with the aim of applying it as a membrane for use in a guided bone regeneration (GBR) system. Another electrospun fiber mat using a previously described composite consisting of SiV and poly(L-lactic acid) (denoted by SiPVH) was also prepared as a comparative sample. SiPLG VH fiber mats showed superior results in terms of mechanical tensile properties and cellular behavior. Their elongation before failure was about eight times higher than that of SiPVH. The numbers of osteoblast-like cells that proliferated on the SiPLGVH fiber mats, regardless of the hydroxyapatite coating, were comparable to that of SiPVH. The cells spread more, two dimensionally, on the SiPLGVH fiber mats, since the pores between fibers were narrowed down because of swelling of the PLGA matrix during cell culture. This two-dimensional cellular proliferation quality on the SiPLGVH fiber mats is expected to be suitable for materials used in GBR, leading to control of infiltration of the soft tissue and great tissue integration with the surrounding tissue.
authors.affiliation: Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan.
authors.forename: Kie
authors.initials: K
authors.lastname: Fujikura
authors.forename: Sen
authors.initials: S
authors.lastname: Lin
authors.forename: Jin
authors.initials: J
authors.lastname: Nakamura
authors.forename: Akiko
authors.initials: A
authors.lastname: Obata
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kasuga
mesh_terms: D016475:3T3 Cells; D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration / Q000187:drug effects*; D002119:Calcium Carbonate / Q000737:chemistry*; D049109:Cell Proliferation; D002478:Cells, Cultured; D017886:Durapatite / Q000737:chemistry; D048091:Guided Tissue Regeneration / Q000379:methods; D019344:Lactic Acid / Q000737:chemistry; D008422:Materials Testing; D051379:Mice; D010006:Osteoblasts / Q000166:cytology; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry; D012833:Siloxanes / Q000737:chemistry*; D013314:Stress, Mechanical; D013718:Tensile Strength; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D012833:Siloxanes; D019344:Lactic Acid; C033616:poly(lactide); D017886:Durapatite; D002119:Calcium Carbonate; D012825:Silicon
keywords: biodegradable polymer; cellular behavior; electrospinning; mechanical properties; polymer composite