title: Effect of calcium phosphate materials on multipotent mesenchymal cells from exfoliated deciduous teeth (SHED cells) in vitro.
abstract: Various calcium phosphate ceramic materials were created and their effect on cultured mesenchymal cells from exfoliated deciduous tooth pulp was evaluated. Tricalcium phosphate ceramics provides best cell survival and is an optimal material for bone tissue engineering. Analysis of the effects of tricalcium phosphate ceramics on osteogenic differentiation of SHED cells suggests that this material potentiated dexamethasone-induced osteogenic differentiation, which manifested in the increased number of ossification foci and enhanced extracellular matrix production by cells. Thus, the tricalcium phosphate ceramics created by us is a promising biomedical material that can be used for tissue-engineered bone analogs.
authors.affiliation: Stemma Research-and-Production Complex, Moscow, Russia. vakhrunya@gmail.com
authors.forename: I V
authors.initials: IV
authors.lastname: Vakhrushev
authors.forename: V V
authors.initials: VV
authors.lastname: Smirnov
authors.forename: M A
authors.initials: MA
authors.lastname: Goldberg
authors.forename: P A
authors.initials: PA
authors.lastname: Karalkin
authors.forename: A Yu
authors.initials: AY
authors.lastname: Lupatov
authors.forename: S M
authors.initials: SM
authors.lastname: Barinov
authors.forename: K N
authors.initials: KN
authors.lastname: Yarygin
mesh_terms: D001672:Biocompatible Materials; D001842:Bone and Bones; D002130:Calcium Phosphates / Q000494:pharmacology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002516:Ceramics; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D010012:Osteogenesis; D023822:Tissue Engineering; D054457:Tissue Scaffolds; D014094:Tooth, Deciduous / Q000166:cytology*
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; C018392:tricalcium phosphate