title: Effects of testosterone treatment on bone mineral density in men with testosterone deficiency syndrome.
abstract: The decline in testosterone levels found in men with testosterone deficiency syndrome (TDS) is associated with a decrease in bone mineral density (BMD). To study the safety profile and efficacy of testosterone treatment on BMD in patients with TDS. In this 2-year prospective open-label study, patients were administered 50 mg of testosterone gel daily (adjustable after 3 months up to 75-100 mg or down to 25 mg) for 12 months, followed by treatment with 1000 mg of testosterone undecanoate every 2-3 months from months 12-24. Outcome measures were as follows: (i) Changes in clinical chemistry safety parameters and total testosterone, sex hormone binding globulin and calculated free testosterone (cFT) levels; (ii) Changes in Aging Males' Symptoms Scale (AMS) and International Prostate Symptom Score scores; and (iii) Changes in lumbar spine and hip BMD. A total of 50 men aged 50-65 years with TDS (AMS >26 and cFT <0.250 nmol/mL) took part in the study. There was no significant impact of testosterone on safety. Prostate-specific antigen and haematopoietic parameters increased significantly, although the changes were not clinically significant. Total and cFT increased significantly after 3 months (p < 0.001) and there were significant improvements after 3 months in AMS scores (p < 0.001). BMD improved significantly in L2-L4 (2.90 and 4.5%), total femur (0.74 and 3%) and trochanter (1.09 and 3.2%) at 12 and 24 months respectively. Testosterone treatment in men with TDS has a good safety profile, leads to significant improvement in lumbar spine and hip BMD, and improves symptoms, as assessed by the AMS questionnaire.
authors.affiliation: Department of Urology, Hospital Universitari de Bellvitge, L'Hospitalet, Spain. joseprtol@gmail.com
authors.forename: J
authors.initials: J
authors.lastname: Rodriguez-Tolrà
authors.forename: J
authors.initials: J
authors.lastname: Torremadé
authors.forename: S
authors.initials: S
authors.lastname: di Gregorio
authors.forename: L
authors.initials: L
authors.lastname: Del Rio
authors.forename: E
authors.initials: E
authors.lastname: Franco
mesh_terms: D015502:Absorptiometry, Photon; D000279:Administration, Cutaneous; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000187:drug effects*; D005500:Follow-Up Studies; D005782:Gels; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000187:drug effects*; D020249:Hormone Replacement Therapy / Q000009:adverse effects; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013030:Spain; D011795:Surveys and Questionnaires; D013577:Syndrome; D013739:Testosterone / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000172:deficiency*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D005782:Gels; D013739:Testosterone