title: Disruption of the blood-brain barrier in pigs naturally infected with Taenia solium, untreated and after anthelmintic treatment.
abstract: Neurocysticercosis is a widely prevalent disease in the tropics that causes seizures and a variety into of neurological symptoms in most of the world. Experimental models are limited and do not allow assessment of the degree of inflammation around brain cysts. The vital dye Evans Blue (EB) was injected to 11 pigs naturally infected with Taenia solium cysts to visually identify the extent of disruption of the blood-brain barrier. A total of 369 cysts were recovered from the 11 brains and classified according to the staining of their capsules as blue or unstained. The proportion of cysts with blue capsules was significantly higher in brains from pigs that had received anthelmintic treatment 48 and 120h before the EB infusion, indicating a greater compromise of the blood-brain barrier due to treatment. The model could be useful for understanding the pathology of treatment-induced inflammation in neurocysticercosis.
authors.affiliation: Laboratorio de Inmunopatología en Neurocisticercosis, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru. cristina.guerra@upch.pe
authors.forename: Cristina
authors.initials: C
authors.lastname: Guerra-Giraldez
authors.forename: Miguel
authors.initials: M
authors.lastname: Marzal
authors.forename: Carla
authors.initials: C
authors.lastname: Cangalaya
authors.forename: Diana
authors.initials: D
authors.lastname: Balboa
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Orrego
authors.forename: Adriana
authors.initials: A
authors.lastname: Paredes
authors.forename: Eloy
authors.initials: E
authors.lastname: Gonzales-Gustavson
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Arroyo
authors.forename: Hector H
authors.initials: HH
authors.lastname: García
authors.forename: Armando E
authors.initials: AE
authors.lastname: González
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Mahanty
authors.forename: Theodore E
authors.initials: TE
authors.lastname: Nash
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use*; D001812:Blood-Brain Barrier / Q000469:parasitology / Q000473:pathology*; D001921:Brain / Q000469:parasitology / Q000473:pathology; D004396:Coloring Agents; D005070:Evans Blue; D005119:Extravasation of Diagnostic and Therapeutic Materials; D020019:Neurocysticercosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011223:Praziquantel / Q000494:pharmacology / Q000627:therapeutic use*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy / Q000469:parasitology / Q000473:pathology*; D041201:Taenia solium / Q000187:drug effects
chemical_list: D000871:Anthelmintics; D004396:Coloring Agents; D005070:Evans Blue; D011223:Praziquantel
keywords: Blood–brain barrier; Neurocysticercosis; Praziquantel; Taenia solium