title: Raman and surface-enhanced Raman scattering (SERS) studies of the thrombin-binding aptamer.
abstract: Surface-enhanced Raman scattering is used to study the Raman spectra and peak shifts the thrombin-binding aptamer (TBA) on substrates having two different geometries; one with a single stranded sequence and one with double stranded sequence. The Raman signals of the deoxyribonucleic acids on both substrates are enhanced and specific peaks of bases are identified. These results are highly reproducible and have promising applications in low cost nucleic acid detection.
authors.affiliation: Bioengineering Department, University of Illinois, Chicago, IL 60607, USA. f.author@nist.gov
authors.forename: Tsai-Chin
authors.initials: TC
authors.lastname: Wu
authors.forename: Milana
authors.initials: M
authors.lastname: Vasudev
authors.forename: Mitra
authors.initials: M
authors.lastname: Dutta
authors.forename: Michael A
authors.initials: MA
authors.lastname: Stroscio
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D011188:Potassium / Q000737:chemistry; D013059:Spectrum Analysis, Raman
chemical_list: D052157:Aptamers, Nucleotide; C081676:thrombin aptamer; D006046:Gold; D004247:DNA; D011188:Potassium