title: Clastogenic and anticlastogenic activity of glucocorticoid hormones hydrocortisone and its synthetic analogs prednisolone and dexamethasone.
abstract: Clastogenic and anticlastogenic activity of glucocorticoid hormones hydrocortisone, prednisolone, and dexamethasone was studied by counting chromosome aberrations in Crepis capillaris test system. Hydrocortisone in a concentration of 12.5 mg/ml produced a clastogenic effect and increased the number of chromosome aberrations in comparison with spontaneous level. Hydrocortisone (6.25 and 3.13 mg/ml), prednisolone (15, 7.5, and 3.75 mg/ml), and dexamethasone (1, 0.5, 0.25, and 0.125 mg/ml) exhibited an anticlastogenic effect and reduced ethyl methanesulfonate-induced mutagenesis.
authors.affiliation: Kazan State Medical University, Russia. kelens@mail.ru
authors.forename: E S
authors.initials: ES
authors.lastname: Koshpaeva
authors.forename: V V
authors.initials: VV
authors.lastname: Semenov
mesh_terms: D016587:Antimutagenic Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects*; D027468:Crepis / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology* / Q000633:toxicity; D005020:Ethyl Methanesulfonate / Q000633:toxicity; D006854:Hydrocortisone / Q000494:pharmacology* / Q000633:toxicity; D016296:Mutagenesis / Q000187:drug effects*; D009153:Mutagens / Q000633:toxicity*; D011239:Prednisolone / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D016587:Antimutagenic Agents; D009153:Mutagens; D003907:Dexamethasone; D005020:Ethyl Methanesulfonate; D011239:Prednisolone; D006854:Hydrocortisone