title: Sub-10 nm Fe3O4@Cu(2-x)S core-shell nanoparticles for dual-modal imaging and photothermal therapy.
abstract: Photothermal nanomaterials have recently attracted significant research interest due to their potential applications in biological imaging and therapeutics. However, the development of small-sized photothermal nanomaterials with high thermal stability remains a formidable challenge. Here, we report the rational design and synthesis of ultrasmall (<10 nm) Fe3O4@Cu2-xS core-shell nanoparticles, which offer both high photothermal stability and superparamagnetic properties. Specifically, these core-shell nanoparticles have proven effective as probes for T2-weighted magnetic resonance imaging and infrared thermal imaging because of their strong absorption at the near-infrared region centered around 960 nm. Importantly, the photothermal effect of the nanoparticles can be precisely controlled by varying the Cu content in the core-shell structure. Furthermore, we demonstrate in vitro and in vivo photothermal ablation of cancer cells using these multifunctional nanoparticles. The results should provide improved understanding of synergistic effect resulting from the integration of magnetism with photothermal phenomenon, important for developing multimode nanoparticle probes for biomedical applications.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Tian
authors.forename: Junqing
authors.initials: J
authors.lastname: Hu
authors.forename: Yihan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Rujia
authors.initials: R
authors.lastname: Zou
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Chen
authors.forename: Shiping
authors.initials: S
authors.lastname: Yang
authors.forename: Runwei
authors.initials: R
authors.lastname: Li
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Su
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000627:therapeutic use; D003300:Copper / Q000737:chemistry / Q000627:therapeutic use; D005290:Ferric Compounds / Q000737:chemistry / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D060328:Magnetic Phenomena; D008279:Magnetic Resonance Imaging; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D010316:Particle Size; D010789:Phototherapy; D013499:Surface Properties
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide; D003300:Copper; C017846:cupric sulfide