title: The impact of prolactin-raising antipsychotics on bone mineral density in patients with schizophrenia: findings from a longitudinal observational cohort.
abstract: To examine the effect of prolactin-raising antipsychotics on bone mineral density (BMD), data of 164 schizophrenia patients who received ≥2 dual-energy x-ray absorptiometry scans were analyzed (49.3% men; mean ± SD age: 58.5 ± 11.0 years; duration of treatment: 26.7 ± 13.8 years). Patients were divided into a prolactin-raising antipsychotic (n=141) or prolactin-sparing (n=23) group, and time x group interaction was examined using mixed effect model. Although the BMD difference did not reach significance over 3.4 ± 1.6 years, a significant antipsychotic-class vs. time interaction was found (p=0.011), indicating a negative impact of prolactin-raising antipsychotics on BMD. Large-scale, randomized-controlled data are required to replicate and extend these findings.
authors.affiliation: Keio University School of Medicine, Department of Neuropsychiatry, Tokyo, Japan.
authors.forename: Tatsuichiro
authors.initials: T
authors.lastname: Takahashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Uchida
authors.forename: Majnu
authors.initials: M
authors.lastname: John
authors.forename: Jinichi
authors.initials: J
authors.lastname: Hirano
authors.forename: Koichiro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Masaru
authors.initials: M
authors.lastname: Mimura
authors.forename: Christoph U
authors.initials: CU
authors.lastname: Correll
authors.forename: Taishiro
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D015519:Bone Density / Q000187:drug effects*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019370:Observation; D011388:Prolactin / Q000378:metabolism*; D012189:Retrospective Studies; D012559:Schizophrenia / Q000188:drug therapy*; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D011388:Prolactin