title: Voltammetric determination of cyproterone acetate in pharmaceutical preparations.
abstract: The voltammetric behaviour of cyproterone acetate (CPA) was studied using direct current (DCt) and differential pulse polarography (DPP). The drug manifests cathodic waves over the pH range of 4-11.8. In Britton-Robinson buffer (BRb) of pH 10, the diffusion current-concentration relationship was found to be rectilinear over the range 3.2-32 μg/mL and 0.5-14 μg/mL using DCt and DPP modes, respectively, with minimum limits of detection (LOD) of 0.13 μg/mL using the DDP. The diffusion-current constant (Id) was 9.29 ± 0.046 (n=9). The proposed method was successfully applied to the determination of the studied compound in its formulations. The mean percentage recoveries in tablets were 99.48 ± 1.25 and 100.01 ± 1.07 (n=4) using DCt and DPP modes, respectively. The results obtained were in agreement with those of the reference method. A proposal for the electrode reaction was postulated.
authors.affiliation: Department of Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt;
authors.forename: Nahed
authors.initials: N
authors.lastname: El-Enany
authors.forename: Dina
authors.initials: D
authors.lastname: El-Sherbiny
authors.forename: Fathalla
authors.initials: F
authors.lastname: Belal
keywords: Direct Current time controlled (DCt); cyproterone acetate; differential pulse (DPP); pharmaceutical dosage forms