title: Bifidobacterium breve B-3 exerts metabolic syndrome-suppressing effects in the liver of diet-induced obese mice: a DNA microarray analysis.
abstract: We previously reported that supplementation with Bifidobacterium breve B-3 reduced body weight gain and accumulation of visceral fat in a dose-dependent manner, and improved serum levels of total cholesterol, glucose and insulin in a mouse model of diet-induced obesity. In this study, we investigated the expression of genes in the liver using DNA microarray analysis and q-PCR to reveal the mechanism of these anti-obesity effects in this mouse model. Administration of B. breve B-3 led to regulated gene expression of pathways involved in lipid metabolism and response to stress. The results indicate that these regulations in the liver are related to the anti-metabolic syndrome effects of B. breve B-3.
authors.affiliation: Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd., 5-1-83, Higashihara, 252-8583 Kanagawa, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kondo
authors.forename: A
authors.initials: A
authors.lastname: Kamei
authors.forename: J Z
authors.initials: JZ
authors.lastname: Xiao
authors.forename: K
authors.initials: K
authors.lastname: Iwatsuki
authors.forename: K
authors.initials: K
authors.lastname: Abe
mesh_terms: D000818:Animals; D001644:Bifidobacterium / Q000502:physiology*; D001691:Biological Therapy / Q000379:methods*; D004032:Diet / Q000379:methods*; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D008099:Liver / Q000473:pathology*; D024821:Metabolic Syndrome / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008820:Mice, Obese; D046228:Microarray Analysis; D009765:Obesity / Q000150:complications*; D019936:Probiotics / Q000008:administration & dosage*; D060888:Real-Time Polymerase Chain Reaction