title: Chitosan-cross-linked osmium polymer composites as an efficient platform for electrochemical biosensors.
abstract: A new family of chitosan-cross-linked osmium polymer composites was prepared and its electrochemical properties were examined. The composites were prepared by quaternization of the poly(4-vinylpyridine) osmium bipyridyl polymer (PVP-Os) which was then cross-linked with chitosan, yielding PVP-Os/chitosan. Films made of the composites showed improved mass and electron transport owing to the porous and hydrophilic structure which is derived from the cross-links between the Os polymer and chitosan. The rate for glucose oxidation was enhanced four times when glucose oxidase (GOx) was immobilized on PVP-Os/chitosan compared immobilization on PVP-Os.
authors.affiliation: Department of Chemistry and Interdisciplinary Program of Integrated Biotechnology, Sogang University, Seoul 121-742, Republic of Korea.
authors.forename: Harishchandra Digambar
authors.initials: HD
authors.lastname: Jirimali
authors.forename: Rajaram Krishna
authors.initials: RK
authors.lastname: Nagarale
authors.forename: Jong Myung
authors.initials: JM
authors.lastname: Lee
authors.forename: Durai
authors.initials: D
authors.lastname: Saravanakumar
authors.forename: Woonsup
authors.initials: W
authors.lastname: Shin
mesh_terms: D015374:Biosensing Techniques; D048271:Chitosan / Q000737:chemistry* / Q000378:metabolism; D055664:Electrochemical Techniques; D005947:Glucose / Q000737:chemistry / Q000378:metabolism; D005949:Glucose Oxidase / Q000737:chemistry / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism; D009992:Osmium / Q000737:chemistry* / Q000378:metabolism; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D016062:Porosity; D013499:Surface Properties
chemical_list: D009942:Organometallic Compounds; D011108:Polymers; D009992:Osmium; D048271:Chitosan; D005949:Glucose Oxidase; D005947:Glucose
keywords: chitosan composites; electron transfer; glucose sensors; polymers; porous films