title: Association between waking electroencephalography and cognitive event-related potentials in patients with obstructive sleep apnea.
abstract: OBJECTIVE
  Sleepiness, cognitive deficits, abnormal event-related potentials (ERP), and slowing of the waking electroencephalography (EEG) activity have been reported in patients with obstructive sleep apnea (OSA). Our study aimed at evaluating if an association exists between the severity of ERP abnormalities and EEG slowing to better understand cerebral dysfunctions in OSA.
  
  
  METHODS
  Twelve OSA patients and 12 age-matched controls underwent an overnight polysomnographic recording, an EEG recording of 10 min of wakefulness, and an auditory ERP protocol known to specifically recruit attention. P300 and P3a ERP components were measured as well as the spectral power in each frequency band of the waking EEG. Pearson product moment correlations were used to measure associations between ERP characteristics and EEG spectral power in OSA patients and control subjects.
  
  
  RESULTS
  A positive correlation between the late P300 amplitude and θ power in the occipital region was observed in OSA subjects (P<.01). A positive correlation was also found between P3a amplitude and β1 power in central region in OSA subjects (P<.01). No correlation was observed for control subjects.
  
  
  CONCLUSIONS
  ERP abnormalities observed in an attention task are associated with a slowing of the waking EEG recorded at rest in OSA.
authors.affiliation: Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Montreal, Québec, Canada.
authors.forename: Andrée-Ann
authors.initials: AA
authors.lastname: Baril
authors.forename: Katia
authors.initials: K
authors.lastname: Gagnon
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Gagnon
authors.forename: Jacques
authors.initials: J
authors.lastname: Montplaisir
authors.forename: Nadia
authors.initials: N
authors.lastname: Gosselin
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology; D004569:Electroencephalography / Q000379:methods*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*; D012894:Sleep Stages / Q000502:physiology; D014851:Wakefulness / Q000502:physiology*
keywords: Attention; Cognition; Event-related potentials; Obstructive sleep apnea; P300; P3a; Quantitative electroencephalography; Vigilance