title: High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards.
abstract: OBJECTIVE
  To examine the correlation in genes expressed in paired umbilical cord blood (UCB) and newborn blood (NB).
  
  
  METHODS
  Total mRNA and mRNA of three gene sets (inflammatory, hypoxia, and thyroidal response) was assessed using microarray in UCB and NB spotted on Guthrie cards from 7 mother/infant pairs.
  
  
  RESULTS
  The average gene expression correlation between paired UCB and NB samples was 0.941 when all expressed genes were considered, and 0.949 for three selected gene sets.
  
  
  CONCLUSIONS
  The high correlation of UCB and NB gene expression suggest that either source may be useful for examining gene expression in the perinatal period.
authors.affiliation: Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University , East Lansing, MI , USA .
authors.forename: Jaime
authors.initials: J
authors.lastname: Slaughter
authors.forename: Changshuai
authors.initials: C
authors.lastname: Wei
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Korzeniewski
authors.forename: Qing
authors.initials: Q
authors.lastname: Lu
authors.forename: John S
authors.initials: JS
authors.lastname: Beck
authors.forename: Sok Kean
authors.initials: SK
authors.lastname: Khoo
authors.forename: Ariel
authors.initials: A
authors.lastname: Brovont
authors.forename: Joel
authors.initials: J
authors.lastname: Maurer
authors.forename: Denny
authors.initials: D
authors.lastname: Martin
authors.forename: Madeleine
authors.initials: M
authors.lastname: Lenski
authors.forename: Nigel
authors.initials: N
authors.lastname: Paneth
mesh_terms: D001800:Blood Specimen Collection / Q000379:methods; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D015870:Gene Expression; D020869:Gene Expression Profiling; D006262:Health; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D020411:Oligonucleotide Array Sequence Analysis; D011247:Pregnancy