title: Foxp3(+) regulatory T cells in mouse models of type 1 diabetes.
abstract: Studies on human type 1 diabetes (T1D) are facilitated by the availability of animal models such as nonobese diabetic (NOD) mice that spontaneously develop autoimmune diabetes, as well as a variety of genetically engineered mouse models with reduced genetic and pathogenic complexity, as compared to the spontaneous NOD model. In recent years, increasing evidence has implicated CD4(+)CD25(+) regulatory T (Treg) cells expressing the transcription factor Foxp3 in both the breakdown of self-tolerance and the restoration of immune homeostasis in T1D. In this paper, we provide an overview of currently available mouse models to study the role of Foxp3(+) Treg cells in the control of destructive β cell autoimmunity, including a novel NOD model that allows specific and temporally controlled deletion of Foxp3(+) Treg cells.
authors.affiliation: Center for Regenerative Therapies Dresden, 01307 Dresden, Germany.
authors.forename: Cathleen
authors.initials: C
authors.lastname: Petzold
authors.forename: Julia
authors.initials: J
authors.lastname: Riewaldt
authors.forename: Deepika
authors.initials: D
authors.lastname: Watts
authors.forename: Tim
authors.initials: T
authors.lastname: Sparwasser
authors.forename: Sonja
authors.initials: S
authors.lastname: Schallenberg
authors.forename: Karsten
authors.initials: K
authors.lastname: Kretschmer