title: Reversal of moderate and intense neuromuscular block induced by rocuronium with low doses of sugammadex for intraoperative facial nerve monitoring.
abstract: We report two cases in which moderate and intense rocuronium-induced neuromuscular block was reversed intraoperatively with low sugammadex doses in order to facilitate electromyographic evaluation of facial nerve function during surgery of the parotid gland and the middle ear. Acceleromyography was used to assess reversal of neuromuscular block before starting electromyography monitoring. Rocuronium-induced neuromuscular block was reversed with sugammadex 0.22mgkg(-1) when the TOF ratio was 0.14 in the first patient, and with sugammadex 2mgkg(-1) during intense block (PTC 0) in the second patient. In each case, appropriate neuromuscular function (TOF ratio≥0.9) was established soon after sugammadex administration, and electromyographic evaluation of facial nerve was successfully conducted. The use of rocuronium and sugammadex, coupled with objective neuromuscular monitoring with acceleromyography, assured complete restoration of neuromuscular function and created the optimal conditions for the surgical team.
authors.affiliation: Department of Anesthesia and Perioperative Care, Complejo Hospitalario Universitario Santa Lucía/Santa María del Rosell, Cartagena, Murcia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Fabregat López
authors.forename: G
authors.initials: G
authors.lastname: Porta Vila
authors.forename: M
authors.initials: M
authors.lastname: Martin-Flores
mesh_terms: D000328:Adult; D000732:Androstanols / Q000627:therapeutic use*; D005154:Facial Nerve / Q000502:physiology*; D006801:Humans; D064795:Intraoperative Neurophysiological Monitoring / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019148:Neuromuscular Blockade / Q000379:methods*; D003473:Neuromuscular Nondepolarizing Agents / Q000627:therapeutic use*; D000077123:Rocuronium; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000008:administration & dosage*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium
keywords: Intraoperative facial nerve monitoring; Monitorización intraoperatoria del nervio facial; Monitorización neuromuscular; Neuromuscular monitoring; Rocuronium; Sugammadex