title: Posterior capsule opacification with the iMics1 NY-60 and AcrySof SN60WF 1-piece hydrophobic acrylic intraocular lenses: 3-year results of a randomized trial.
abstract: OBJECTIVE
  To compare the intensity of posterior capsule opacification (PCO) 3 years after implantation of 2 different 1-piece foldable hydrophobic acrylic intraocular lenses (IOLs).
  
  
  METHODS
  Randomized, prospective, patient- and examiner-masked clinical trial with intraindividual comparison.
  
  
  METHODS
  One hundred patients with bilateral age-related cataract (200 eyes) had standard cataract surgery with implantation of an iMics1 NY-60 IOL (Hoya Corp) in one eye and an AcrySof SN60WF IOL (Alcon Laboratories) in the other eye. Follow-up examinations were performed at 1 week and 3 years. Digital retroillumination images were obtained of each eye. The main outcome measure was PCO score (scale, 0 to 10) assessed subjectively at the slit lamp and objectively using automated image analysis software (Automated Quantification of After-Cataract) 3 years after surgery.
  
  
  RESULTS
  The objective PCO score (mean ± standard deviation) was 3.0 ± 2.0 for the iMics1 NY-60 IOL and 1.9 ± 1.4 for the AcrySof SN60WF IOL (P < .001). Three years after surgery, 35.6% of patients underwent a neodymium:yttrium-aluminum-garnet capsulotomy in the iMics1 NY-60 eye and 13.7% underwent a capsulotomy in the AcrySof SN60WF eye (P = .001). There was no statistically significant difference in best-corrected visual acuity, rhexis-IOL overlap, capsular folds, or anterior capsule opacification. Glistening formations were found in no iMics1 NY-60 IOLs, but in 97% of the AcrySof SN60WF IOLs.
  
  
  CONCLUSIONS
  Comparison of 2 sharp-edged single-piece IOLs of similar design and hydrophobic acrylic material indicated a statistically significant difference in PCO and neodymium:yttrium-aluminum-garnet capsulotomy rate 3 years after surgery.
authors.affiliation: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
authors.forename: Christina
authors.initials: C
authors.lastname: Leydolt
authors.forename: Sabine
authors.initials: S
authors.lastname: Schriefl
authors.forename: Eva
authors.initials: E
authors.lastname: Stifter
authors.forename: Alexandra
authors.initials: A
authors.lastname: Haszcz
authors.forename: Rupert
authors.initials: R
authors.lastname: Menapace
mesh_terms: D000180:Acrylic Resins; D000368:Aged; D058442:Capsule Opacification / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D053685:Laser Therapy; D053844:Lasers, Solid-State / Q000627:therapeutic use; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008297:Male; D018918:Phacoemulsification; D057852:Posterior Capsule of the Lens / Q000473:pathology*; D011446:Prospective Studies; D011474:Prosthesis Design; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000180:Acrylic Resins