title: Sphingosine kinase: a closer look at last.
abstract: Sphingosine-1-phosphate is a potent sphingolipid mediator, and the kinase that produces it, sphingosine kinase 1 (SphK1), has been implicated in cancer progression, inflammation, and cardiovascular diseases. In this issue of Structure, Wang and colleagues provide the scientific community with the long awaited structure of SphK1.
authors.affiliation: Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
authors.forename: Santiago
authors.initials: S
authors.lastname: Lima
authors.forename: Sarah
authors.initials: S
authors.lastname: Spiegel