title: [Glycosyl isomerization based on the biosynthesis of natural-product sugar from microorganism].
abstract: Glycosylation, one of the most common and important reactions in biological systems, results in diverse functions and is often found in biologically active small-molecule natural products produced by microorganisms. Furthermore, sugar moieties are generally critical for their activities. Alternating the sugar structures thus provides the potentials for enhancing the biological activities of natural products, which evokes researchers to study the sugar biosynthetic machinery and its application in the modification of sugar moieties with an aim of generating unnaturally glycosylated natural product drugs with better activities. This review will briefly outline current studies on sugar biosynthesis and glycosyltransferase, with a few selected experiments designed to alter natural-product sugar structures.
authors.affiliation: Pharmaceutic Academy, Chinese Academy of Medical Sciences & Peking Union Medial College, Beijing 100050, China.
authors.forename: Wan
authors.initials: W
authors.lastname: Sun
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Wang
authors.forename: Zhao-Yong
authors.initials: ZY
authors.lastname: Yang
mesh_terms: D000880:Anthraquinones / Q000378:metabolism; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D002241:Carbohydrates / Q000096:biosynthesis* / Q000737:chemistry; D004917:Erythromycin / Q000096:biosynthesis*; D006031:Glycosylation; D016695:Glycosyltransferases / Q000096:biosynthesis*; D007536:Isomerism; D015394:Molecular Structure; D016930:Saccharopolyspora / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism; D058615:Synthetic Biology
chemical_list: D000880:Anthraquinones; D001688:Biological Products; D002241:Carbohydrates; D004917:Erythromycin; C047329:elloramycin; D016695:Glycosyltransferases