title: Lactobacillus plantarum OLL2712 regulates glucose metabolism in C57BL/6 mice fed a high-fat diet.
abstract: The aim of the present study was to determine the effect of oral administration of Lactobacillus plantarum OLL2712 (L. plantarum OLL2712) on glucose and lipid metabolism in mice with high-fat diet-induced obesity. Mice that had been administered 10(9) cfu heat-killed L. plantarum OLL2712 for 12 wk showed significant reduction of blood glucose levels in response to insulin. Furthermore, mRNA expression of interleukin-1β in adipose tissue and serum levels of nonesterified fatty acids in mice administered L. plantarum OLL2712 were significantly lower than those in control mice. These results indicate that L. plantarum OLL2712 regulates glucose metabolism.
authors.affiliation: Department of Public Health and Applied Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto, Tokushima, Japan. tohrus@nutr.med.tokushima-u.ac.jp
authors.forename: Tohru
authors.initials: T
authors.lastname: Sakai
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Taki
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakamoto
authors.forename: Emi
authors.initials: E
authors.lastname: Shuto
authors.forename: Rie
authors.initials: R
authors.lastname: Tsutsumi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Toshimitsu
authors.forename: Seiya
authors.initials: S
authors.lastname: Makino
authors.forename: Shuuji
authors.initials: S
authors.lastname: Ikegami
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007328:Insulin / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D048191:Lactiplantibacillus plantarum; D050356:Lipid Metabolism / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000378:metabolism; D019936:Probiotics; D012333:RNA, Messenger / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D053583:Interleukin-1beta; D012333:RNA, Messenger; D014280:Triglycerides; D002784:Cholesterol