title: One-pot synthesis of substituted tetrahydrocyclobuta[a]naphthalenes by domino aldol condensation/olefin migration/electrocyclization.
abstract: A facile one-pot synthetic route for preparing the novel benzofused tricyclic skeleton of 1,2,2a,8b-tetrahydrocyclobuta[a]naphthalenes 5 is developed. The route was realized by a NaH-mediated tandem aldol condensation/olefin migration/electrocyclization of o-allylbenzaldehydes 1 with cinnamyl sulfones 3 in good yields.
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan. mychang@kmu.edu.tw
authors.forename: Meng-Yang
authors.initials: MY
authors.lastname: Chang
authors.forename: Ming-Hao
authors.initials: MH
authors.lastname: Wu
authors.forename: Yeh-Long
authors.initials: YL
authors.lastname: Chen
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry*; D002384:Catalysis; D002934:Cinnamates / Q000737:chemistry*; D003500:Cyclization; D003503:Cyclobutanes / Q000737:chemistry*; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D001547:Benzaldehydes; D002934:Cinnamates; D003503:Cyclobutanes; D009281:Naphthalenes