title: Secretory IgA specific for MPER can protect from HIV-1 infection in vitro.
abstract: This preliminary study was performed to assess the neutralization activity of anti-MPER-secretory IgA (SIgA) from parotid saliva in 88 HIV+ patients, in five exposed seronegative (ESN) and in five seronegative volunteers. 48.9% of the HIV+ patients and 100% of ESN patients showed antigp41 SIgA. 25.6% of anti-MPER SIgA from HIV+ patients and 100% from ESN patients neutralized efficiently HIV-1 primary isolate SF162 (IC 50). The neutralization activity is maintained for much lower concentrations in ESN than in HIV+ secretions.
authors.forename: Fahd
authors.initials: F
authors.lastname: Benjelloun
authors.forename: Reham
authors.initials: R
authors.lastname: Dawood
authors.forename: Silvio
authors.initials: S
authors.lastname: Urcuqui-Inchima
authors.forename: Nicolas
authors.initials: N
authors.lastname: Rochereau
authors.forename: Blandine
authors.initials: B
authors.lastname: Chanut
authors.forename: Bernard
authors.initials: B
authors.lastname: Verrier
authors.forename: Frederic
authors.initials: F
authors.lastname: Lucht
authors.forename: Christain
authors.initials: C
authors.lastname: Genin
authors.forename: Stéphane
authors.initials: S
authors.lastname: Paul
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology*; D005260:Female; D015483:HIV Antibodies / Q000276:immunology*; D015700:HIV Envelope Protein gp41 / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal; D007071:Immunoglobulin A, Secretory / Q000276:immunology*; D008297:Male; D012463:Saliva / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D015483:HIV Antibodies; D015700:HIV Envelope Protein gp41; D007071:Immunoglobulin A, Secretory; C514787:gp41 protein, Human immunodeficiency virus 1