title: Retinoid X receptors in macrophage biology.
abstract: Retinoid X receptors (RXRs) form a distinct and unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs regulate a plethora of genetic programs, including cell differentiation, the immune response, and lipid and glucose metabolism. Recent advances reveal that RXRs are important regulators of macrophages, key players in inflammatory and metabolic disorders. This review outlines the versatility of RXR action in the control of macrophage gene transcription through its heterodimerization with other NRs or through RXR homodimerization. We also highlight the potential of RXR-controlled transcriptional programs as targets for the treatment of pathologies associated with altered macrophage function, such as atherosclerosis, insulin resistance, autoimmunity, and neurodegeneration.
authors.affiliation: Cardiovascular Development and Repair Department, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain.
authors.forename: Tamás
authors.initials: T
authors.lastname: Rőszer
authors.forename: María P
authors.initials: MP
authors.lastname: Menéndez-Gutiérrez
authors.forename: Marta
authors.initials: M
authors.lastname: Cedenilla
authors.forename: Mercedes
authors.initials: M
authors.lastname: Ricote
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D047488:Retinoid X Receptors / Q000276:immunology*
chemical_list: D047488:Retinoid X Receptors
keywords: gene transcription; inflammation; lipid metabolism; macrophage; nuclear receptors