title: Impact of multidrug-resistant organisms on patients considered for lung transplantation.
abstract: Infections with multidrug-resistant organisms are a growing problem in lung transplant recipients. Carriage of drug-resistant bacteria and fungi before transplantation is an important risk factor for such infections. In that regard Pseudomonas aeruginosa and species of Burkholderia, Acinetobacter, non-tuberculous mycobacteria and Scedosporium are particularly important. An understanding of the impact of these organisms is essential to the evaluation of lung transplant candidates. The microbiology, epidemiology, clinical manifestations, and approach to these pathogens before transplant are reviewed in this article.
authors.affiliation: Transplant and Oncology Infectious Diseases Program, Johns Hopkins University School of Medicine, 1830 Baltimore, MD 21205, USA. sshoham1@jhmi.edu
authors.forename: Shmuel
authors.initials: S
authors.lastname: Shoham
authors.forename: Pali D
authors.initials: PD
authors.lastname: Shah
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy* / Q000517:prevention & control; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D016867:Immunocompromised Host; D016040:Lung Transplantation; D009894:Opportunistic Infections / Q000188:drug therapy* / Q000517:prevention & control; D057285:Precision Medicine / Q000379:methods; D014180:Transplantation
chemical_list: D000900:Anti-Bacterial Agents