title: Triterpenes with cytotoxicity from the leaves of Vernicia fordii.
abstract: Two new triterpenes, (1α,3β,8α,9β,10α,13α,14β)-9,10-dimethyl-25,26-dinorolean-5-en-1,3-diol (1) and (1α,3β,6β)-olean-12-en-1,3,6-triol (2) were isolated from the leaves of Aleurites fordii, together with five known triterpenes. The structures of isolates were established by one dimensional (1D)- and 2D-NMR spectroscopic data along with MS analysis. Of the isolated compounds, 1, 2 and 4 (daturadiol) displayed moderate cytotoxicities against two or more human cancer cell lines in HepG2 (hepatocellular carcinoma), SK-OV-3 (ovarian carcinoma), A-549 (lung carcinoma) and SNU-1 (gastric carcinoma).
authors.affiliation: University of Science & Technology, Daejeon, Korea.
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Pei
authors.forename: Ok-Kyoung
authors.initials: OK
authors.lastname: Kwon
authors.forename: Ji-Seon
authors.initials: JS
authors.lastname: Lee
authors.forename: Hyuk-Jin
authors.initials: HJ
authors.lastname: Cha
authors.forename: Kyung-Seop
authors.initials: KS
authors.lastname: Ahn
authors.forename: Sei-Ryang
authors.initials: SR
authors.lastname: Oh
authors.forename: Hyeong-Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D019665:Euphorbiaceae / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: C585169:(1alpha,3beta,6beta)-olean-12-en-1,3,6-triol; C585170:(1alpha,3beta,8alpha,9beta,10alpha,13alpha,14beta)-9,10-dimethyl-25,26-dinorolean-5-en-1,3-diol; D014315:Triterpenes