title: Amine-N-heterocyclic carbene cascade catalysis for the asymmetric synthesis of fused indane derivatives with multiple chiral centres.
abstract: An aminocatalytic asymmetric Diels-Alder reaction of 2,4-dienals and labile 1-indenones in situ generated from 3-bromo-1-indanones was developed, producing highly fused indane products with multiple chiral centres followed by a cascade N-heterocyclic carbene-mediated benzoin condensation.
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Jia
authors.forename: Kun
authors.initials: K
authors.lastname: Jiang
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Zhou
authors.forename: Lin
authors.initials: L
authors.lastname: Dong
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000588:Amines / Q000737:chemistry*; D001573:Benzoin / Q000737:chemistry; D002384:Catalysis; D061565:Cycloaddition Reaction; D007189:Indans / Q000138:chemical synthesis / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D007189:Indans; C030011:carbene; C093582:indan; D001573:Benzoin; D008697:Methane