title: Bat cells from Pteropus alecto are susceptible to influenza A virus infection and reassortment.
abstract: Waterfowl are primary hosts for influenza A viruses (IAVs); however, there is sporadic infection of swine and other species that pose a risk of zoonotic spread. Yellow-shouldered bats were shown to be hosts of an IAV, thereby constituting a potential novel reservoir. We show that Pteropus alecto kidney cells (PaKi) are susceptible to infection and sustain replication of A/WSN/33 (H1N1) and A/Vietnam/1203/04 (H5N1). Importantly, we show that co-infection of PaKi cells results in novel reassortants.
authors.affiliation: Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Dlugolenski
authors.forename: Les
authors.initials: L
authors.lastname: Jones
authors.forename: S Mark
authors.initials: SM
authors.lastname: Tompkins
authors.forename: Gary
authors.initials: G
authors.lastname: Crameri
authors.forename: Lin-Fa
authors.initials: LF
authors.lastname: Wang
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Tripp
mesh_terms: D000818:Animals; D002460:Cell Line; D002685:Chiroptera; D009980:Influenza A virus / Q000502:physiology*; D007668:Kidney; D016865:Reassortant Viruses / Q000502:physiology*; D014779:Virus Replication
keywords: Bats; H1N1; H5N1; influenza; reassortment