title: For which cancer types can neuron-specific enolase be clinically helpful in Turkish patients?
abstract: BACKGROUND
  The aim of the present study was to evaluate the serum neuron-specific enolase (NSE) levels in patients with prostate cancer, Hodgkin lymphoma, lung cancer and peripheral nerve tumors.
  
  
  METHODS
  NSE levels were determined by ELISA in the sera of 100 prostate cancer, 47 Hodgkin lymphoma, 35 lung cancer and 35 peripheral nerve tumor patients and also in 132 healthy controls.
  
  
  RESULTS
  The median levels of serum NSE were elevated in patients with lung cancer (p=0.018) and peripheral nerve tumors (p=0.008). NSE levels in prostate cancer and Hodgkin lymphoma patients were higher than the controls but there was no statistically significant difference (p>0.05).
  
  
  CONCLUSIONS
  We conclude that NSE may be applied in routine to gain insight about the clinical statuses of various cancer patients, but more studies are needed to determine the organ specificity.
authors.affiliation: Basic Oncology, Istanbul University Oncology Institute, Istanbul, Turkey. elifbilgin85@gmail.com
authors.forename: Elif
authors.initials: E
authors.lastname: Bilgin
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Dizdar
authors.forename: Murat
authors.initials: M
authors.lastname: Serilmez
authors.forename: Hilal Oguz
authors.initials: HO
authors.lastname: Soydinc
authors.forename: Ceren Tilgen
authors.initials: CT
authors.lastname: Yasasever
authors.forename: Derya
authors.initials: D
authors.lastname: Duranyildiz
authors.forename: Vildan
authors.initials: V
authors.lastname: Yasasever
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology; D006801:Humans; D007223:Infant; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010524:Peripheral Nervous System Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology; D012372:ROC Curve; D014421:Turkey; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D010751:Phosphopyruvate Hydratase