title: Ribonucleoprotein complexes that control circadian clocks.
abstract: Circadian clocks are internal molecular time-keeping mechanisms that enable organisms to adjust their physiology and behavior to the daily surroundings. Misalignment of circadian clocks leads to both physiological and health impairment. Post-transcriptional regulation and translational regulation of circadian clocks have been extensively investigated. In addition, accumulating evidence has shed new light on the involvement of ribonucleoprotein complexes (RNPs) in the post-transcriptional regulation of circadian clocks. Numerous RNA-binding proteins (RBPs) and RNPs have been implicated in the post-transcriptional modification of circadian clock proteins in different model organisms. Herein, we summarize the advances in the current knowledge on the role of RNP complexes in circadian clock regulation.
authors.affiliation: Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. guojinhu@mail.sysu.edu.cn.
authors.forename: Dongni
authors.initials: D
authors.lastname: Wang
authors.forename: Xiaodi
authors.initials: X
authors.lastname: Liang
authors.forename: Xianyun
authors.initials: X
authors.lastname: Chen
authors.forename: Jinhu
authors.initials: J
authors.lastname: Guo
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000235:genetics; D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D057906:Circadian Clocks / Q000235:genetics; D006801:Humans; D046912:Multiprotein Complexes / Q000378:metabolism*; D026723:Polyadenylation / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012261:Ribonucleoproteins / Q000378:metabolism*
chemical_list: D046912:Multiprotein Complexes; D012333:RNA, Messenger; D012261:Ribonucleoproteins