title: STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells.
abstract: In this study, we aimed to evaluate the cytotoxic and apoptotic effects of zoledronic acid on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on zoledronic acid-induced apoptosis. The results showed that zoledronic acid decreased proliferation, and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT3, -5A and -5B genes were significantly reduced in zoledronic acid-treated K562 cells. These data indicated that STAT inhibition by zoledronic acid may be therapeutic in CML patients following the confirmation with clinical studies.
authors.affiliation: Department of Internal Medicine, School of Medicine, Ege University, Bornova, Izmir, Turkey.
authors.forename: Hatice Demet
authors.initials: HD
authors.lastname: Kiper
authors.forename: Burcin
authors.initials: B
authors.lastname: Tezcanli Kaymaz
authors.forename: Aysun Adan
authors.initials: AA
authors.lastname: Gokbulut
authors.forename: Nur
authors.initials: N
authors.lastname: Selvi
authors.forename: Cigir Biray
authors.initials: CB
authors.lastname: Avci
authors.forename: Buket
authors.initials: B
authors.lastname: Kosova
authors.forename: Guniz
authors.initials: G
authors.lastname: Iskender
authors.forename: Melis Kartal
authors.initials: MK
authors.lastname: Yandim
authors.forename: Cumhur
authors.initials: C
authors.lastname: Gunduz
authors.forename: Fahri
authors.initials: F
authors.lastname: Sahin
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Baran
authors.forename: Guray
authors.initials: G
authors.lastname: Saydam
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004164:Diphosphonates / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D020014:K562 Cells; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D050791:STAT Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D007093:Imidazoles; D050791:STAT Transcription Factors; D000077211:Zoledronic Acid
keywords: Chronic myeloid leukemia; STATs; Zoledronic acid