title: Phenolic glucosides from Dendrobium aurantiacum var. denneanum and their bioactivities.
abstract: A new 8,4'-oxyneolignane glucoside 1 has been isolated from the stems of Dendrobium aurantiacum var. denneanum together with six known phenolic glucosides 2−7. The structure of the new compound, including its absolute configuration, was determined by spectroscopic and chemical methods as (−)-(7S,8R,7'E)-4-hydroxy-3,3',5,5'-tetramethoxy-8,4'-oxyneolign-7'-ene-7,9,9'-triol 7,9'-bis-O-β-D-glucopyranoside (1). In the in vitro assays, compound 1 and (−)-syringaresinol-4,4'-bis-O-β-D-glucopyranoside (2) showed evident activity against glutamate-induced neurotoxicity in PC12 cells. Shashenoside I (4) showed a selective cytotoxic activity with the IC₅₀ value of 4.17 μM against the acute myeloid leukemia cell line MV4-11, while it was inactive against 10 other human tumor cell lines.
authors.affiliation: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Xiong
authors.forename: Zhi-Xing
authors.initials: ZX
authors.lastname: Cao
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Li
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Xie
authors.forename: Ting-Mo
authors.initials: TM
authors.lastname: Zhang
authors.forename: Qin-Mei
authors.initials: QM
authors.lastname: Zhou
authors.forename: Lian
authors.initials: L
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Guo
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D031667:Dendrobium / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D018547:Plant Stems / Q000737:chemistry
chemical_list: D005960:Glucosides; D010636:Phenols; D010936:Plant Extracts