title: High-pressure, compact, modular radiosynthesizer for production of positron emitting biomarkers.
abstract: A robust, modular, semi-automated synthesis unit useful for conducting radiochemical reactions under pressurized conditions (up to ∼200psi [1.4MPa]) for the production of PET biomarkers has been developed. This compact unit (7.6cm×33.0cm×58.4cm) is capable of performing any single step reaction that is generally encountered in radiochemical syntheses, and multiple units can be combined for more complex syntheses. The versatility of a 3-unit system is exemplified by reliably conducting the multi-step syntheses of 2'-deoxy-2'-[(18)F]fluoro-1-β-arabinofuranosyl-uracil and -cytosine derivatives, which involve corrosive and moisture sensitive reagents under pressurized conditions.
authors.affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
authors.forename: Bernard
authors.initials: B
authors.lastname: Amaraesekera
authors.forename: Phillip D
authors.initials: PD
authors.lastname: Marchis
authors.forename: Krzysztof P
authors.initials: KP
authors.lastname: Bobinski
authors.forename: Caius G
authors.initials: CG
authors.lastname: Radu
authors.forename: Johannes
authors.initials: J
authors.lastname: Czernin
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Barrio
authors.forename: R
authors.initials: R
authors.lastname: Michael van Dam
mesh_terms: D003287:Contrast Media / Q000138:chemical synthesis* / Q000302:isolation & purification*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007553:Isotope Labeling / Q000295:instrumentation* / Q000379:methods*; D008904:Miniaturization; D049268:Positron-Emission Tomography / Q000379:methods*; D011312:Pressure; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000302:isolation & purification*
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals