title: Protection of mice against lipopolysaccharide-induced endotoxic shock by pinocembrin is correlated with regulation of cytokine secretion.
abstract: Natural products have been used as potentially important sources of anti-inflammatory drugs. This study examined the effects of pinocembrin against lipopolysaccharide (LPS)-induced endotoxemia to ascertain whether pinocembrin could protect mice from ensuing death. Cytokine responses were also assessed in serum isolated from blood collected at 0, 2, 4, 6, 8, and 24 h after LPS administration of the mice (with or without drug treatment). The results showed that there was a lower production of TNFα, IL-6, and IL-1β in the serum of LPS-challenged mice that had been pre-treated with pinocembrin. In addition, pre-treatment with pinocembrin improved host survival against the LPS-induced lethal endotoxemia. These results suggest that this new flavonoid could potentially be a novel candidate for preventing development/mitigation progression of septic shock.
authors.affiliation: Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University , Xi'an Road 5333, Changchun 130062 , PRC .
authors.forename: Lanan Wassy
authors.initials: LW
authors.lastname: Soromou
authors.forename: Lanxiang
authors.initials: L
authors.lastname: Jiang
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Wei
authors.forename: Na
authors.initials: N
authors.lastname: Chen
authors.forename: Meixia
authors.initials: M
authors.lastname: Huo
authors.forename: Xiao
authors.initials: X
authors.lastname: Chu
authors.forename: Weiting
authors.initials: W
authors.lastname: Zhong
authors.forename: Qianchao
authors.initials: Q
authors.lastname: Wu
authors.forename: Abdourahmane
authors.initials: A
authors.lastname: Baldé
authors.forename: Xuming
authors.initials: X
authors.lastname: Deng
authors.forename: Haihua
authors.initials: H
authors.lastname: Feng
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D044950:Flavanones / Q000008:administration & dosage*; D005786:Gene Expression Regulation; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy / Q000639:trends*; D012772:Shock, Septic; D029647:Turnera / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D044950:Flavanones; D018836:Inflammation Mediators; D008070:Lipopolysaccharides; C016063:pinocembrin