title: Alpha(1A)-adrenergic control of piloerection and palpebral fissure width in rats.
abstract: We determined the receptor subtypes of α1-adrenoceptor, which is involved in autonomic functions induced by methamphetamine (METH) in rats. An intraperitoneal injection of METH provoked the autonomic responses piloerection, eyelid retraction, and ejaculation. Pretreatment with prazosin, a nonselective α1-adrenoceptor antagonist, completely abolished the above METH-induced responses. Prazosin also provoked eyelid ptosis in saline controls. The effects of prazosin were mimicked only by a selective α1A-adrenoceptor antagonist, silodosin, not by selective α1B or α1D antagonists. These results suggest that α1A-adrenoceptor participates in the regulation of piloerection, palpebral fissure width, and ejaculation in rats.
authors.affiliation: Department of Pharmacology, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: Kazue
authors.initials: K
authors.lastname: Kikuchi-Utsumi
authors.forename: Mami
authors.initials: M
authors.lastname: Ishizaka
authors.forename: Nobuko
authors.initials: N
authors.lastname: Matsumura
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakaki
mesh_terms: D018663:Adrenergic Agents / Q000494:pharmacology*; D000818:Animals; D001763:Blepharoptosis / Q000139:chemically induced / Q000378:metabolism; D007211:Indoles / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D010863:Piloerection / Q000187:drug effects / Q000502:physiology*; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism*
chemical_list: D018663:Adrenergic Agents; D007211:Indoles; D018340:Receptors, Adrenergic, alpha-1; D008694:Methamphetamine; C095285:silodosin; D011224:Prazosin
keywords: Autonomic regulation; Ejaculation; Noradrenaline; Palpebral fissure width; Piloerection; α(1)-Adrenoceptor antagonist