title: Giant-cell glioblastoma of childhood associated with HIV-1 and JC virus coinfection.
abstract: OBJECTIVE
  John Cunningham (JC) viral DNA sequence has seldom been reported in patients with brain tumors such as high grade gliomas and medulloblastomas, pointing to a role in the etiopathogenesis of such tumors.
  
  
  RESULTS
  We present a unique clinical case of an HIV-positive pediatric patient with multifocal leukoencephalopathy and confirmed JC virus (JCV) infection that developed a giant-cell glioblastoma.
  
  
  CONCLUSIONS
  Experimental data with infected primates has previously hypothesized an association of human giant-cell glioblastoma with JCV or progressive multifocal leukoencephalopathy, though such association has not been documented in the literature for humans. Future studies with larger cohorts and molecular pathological analyses are still needed to corroborate the role of the widely spread human neurotropic virus in early transformation and in the development of brain tumors with different histology in the setting of HIV-related severe immunosuppression.
authors.affiliation: Department of Pediatrics, Faculty of Medicine of Ribeirão Preto, University of SãoPaulo, SãoPaulo, Brazil. solbrassesco@usp.br
authors.forename: María Sol
authors.initials: MS
authors.lastname: Brassesco
authors.forename: Luiz Guilherme
authors.initials: LG
authors.lastname: Darrigo
authors.forename: Elvis Terci
authors.initials: ET
authors.lastname: Valera
authors.forename: Ricardo Santos
authors.initials: RS
authors.lastname: Oliveira
authors.forename: Yulie Aparecida
authors.initials: YA
authors.lastname: Yamamoto
authors.forename: Marcus Vinícius
authors.initials: MV
authors.lastname: de Castro Barros
authors.forename: Luiz Gonzaga
authors.initials: LG
authors.lastname: Tone
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000209:etiology* / Q000821:virology; D005260:Female; D005909:Glioblastoma / Q000209:etiology* / Q000821:virology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007577:JC Virus / Q000235:genetics / Q000472:pathogenicity; D059785:Karyotype; D008279:Magnetic Resonance Imaging; D027601:Polyomavirus Infections / Q000150:complications*; D014763:Viral Matrix Proteins / Q000378:metabolism
chemical_list: D014763:Viral Matrix Proteins