title: Diagnosing vascular variability anomalies, not only MESOR-hypertension.
abstract: Chronobiology is the study of biological rhythms. Chronomics investigates interactions with environmental cycles in a genetically coded autoresonance of the biosphere with wrangling space and terrestrial weather. Analytical global and local methods applied to human blood pressure records of around-the-clock measurements covering decades detect physiological-physical interactions, a small yet measurable response to solar and terrestrial magnetism. The chronobiological and chronomic interpretation of ambulatory blood pressure monitoring (C-ABPM) records in the light of time-specified reference values derived from healthy peers matched by sex and age identify vascular variability anomalies (VVAs) for an assessment of cardio-, cerebro-, and renovascular disease risk. Even within the conventionally accepted normal range, VVAs have been associated with a statistically significant increase in risk. Long-term C-ABPM records help to "know ourselves," serving for relief of psychological and other strain once transient VVAs are linked to the source of a load, prompting adjustment of one's lifestyle for strain reduction. Persistent circadian VVAs can be treated, sometimes by no more than a change in timing of the daily administration of antihypertensive medication. Circadian VVA assessment is an emergency worldwide, prompted in the United States by 1,000 deaths per day every day from problems related to blood pressure. While some heads of state met under United Nation and World Health Organization sponsorship to declare that noncommunicable diseases are a slow-motion disaster, a resolution has been drafted to propose C-ABPM as an added tool complementing purely physical environmental monitoring to contribute also to the understanding of social and natural as well as personal cataclysms.
authors.affiliation: University of Minnesota Academic Health Center, Minneapolis, MN 55455, USA.
authors.forename: Franz
authors.initials: F
authors.lastname: Halberg
authors.forename: Deborah
authors.initials: D
authors.lastname: Powell
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Otsuka
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Larry A
authors.initials: LA
authors.lastname: Beaty
authors.forename: Paul
authors.initials: P
authors.lastname: Rosch
authors.forename: Jerzy
authors.initials: J
authors.lastname: Czaplicki
authors.forename: Dewayne
authors.initials: D
authors.lastname: Hillman
authors.forename: Othild
authors.initials: O
authors.lastname: Schwartzkopff
authors.forename: Germaine
authors.initials: G
authors.lastname: Cornelissen
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D055870:Drug Chronotherapy; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D008280:Magnetics; D011237:Predictive Value of Tests; D012307:Risk Factors; D040242:Risk Reduction Behavior; D019445:Solar Activity; D013997:Time Factors; D016896:Treatment Outcome; D014887:Weather
chemical_list: D000959:Antihypertensive Agents
keywords: blood pressure; chronomics; combined global and local analyses; coperiodism; space-terrestrial weather; vascular variability anomaly