title: Post marketing surveillance on safety and efficacy of IMOD in Iranian patients with HIV/AIDS.
abstract: Acquired immune deficiency syndrome is one of the world's serious health problems. Immune-based therapy is a new approach in the treatment of HIV infected patients. IMOD™ with the ability to correct immune deficiencies has been introduced for the management of HIV infection. In the phase IV trial study the main objectives were to assess the possible side effects, evaluate its effect on CD4⁺ T lymphocyte count and patients' and physicians' satisfactions for 600 HIV infected patients in 13 centers during 2007. The observed adverse events in patients included: headache and vertigo (1.2%), nausea (1.2%), gastritis (1.2%), phlebitis (1%) and mild rash (1%); serious adverse events were not observed in any of IMOD™ recipients. Therefore it was not needed to terminate the treatment in any of patient. The results of this study demonstrated that daily prescription of IMOD™ significantly increases T lymphocyte CD4⁺ and total lymphocyte count in HIV-positive patients. In addition, nearly 90% of the patients and 70% physicians are satisfied by IMOD™ treatment.
authors.affiliation: Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
authors.forename: Minoo
authors.initials: M
authors.lastname: Mohraz
authors.forename: Abbas
authors.initials: A
authors.lastname: Sedaghat
authors.forename: SeyedAhmad
authors.initials: S
authors.lastname: SeyedAlinaghi
authors.forename: Hossein
authors.initials: H
authors.lastname: Asheri
authors.forename: Saeid
authors.initials: S
authors.lastname: Mohammaddoust
authors.forename: Farhad
authors.initials: F
authors.lastname: Gharibdoost
authors.forename: Hamid Reza Khorram
authors.initials: HR
authors.lastname: Khorshid
authors.forename: Mohammad
authors.initials: M
authors.lastname: Farhadi
authors.forename: Seyed Hesamedin
authors.initials: SH
authors.lastname: Madani
authors.forename: Koorosh
authors.initials: K
authors.lastname: Kamali
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D001291:Attitude of Health Personnel; D018791:CD4 Lymphocyte Count; D004359:Drug Therapy, Combination / Q000009:adverse effects; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects*; D007262:Infusions, Intravenous; D007492:Iran; D018655:Lymphocyte Count; D008297:Male; D017060:Patient Satisfaction; D010820:Physicians; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011358:Product Surveillance, Postmarketing
chemical_list: D019380:Anti-HIV Agents; D044966:Anti-Retroviral Agents; D010936:Plant Extracts; C555145:setarud