title: Chip-scale fluorescence microscope based on a silo-filter complementary metal-oxide semiconductor image sensor.
abstract: We demonstrate a silo-filter (SF) complementary metal-oxide semiconductor (CMOS) image sensor for a chip-scale fluorescence microscope. The extruded pixel design with metal walls between neighboring pixels guides fluorescence emission through the thick absorptive filter to the photodiode of a pixel. Our prototype device achieves 13 μm resolution over a wide field of view (4.8 mm × 4.4 mm). We demonstrate bright-field and fluorescence longitudinal imaging of living cells in a compact, low-cost configuration.
authors.affiliation: Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA. salee30@caltech.edu
authors.forename: Seung
authors.initials: S
authors.lastname: Ah Lee
authors.forename: Xiaoze
authors.initials: X
authors.lastname: Ou
authors.forename: J Eugene
authors.initials: JE
authors.lastname: Lee
authors.forename: Changhuei
authors.initials: C
authors.lastname: Yang
mesh_terms: D004867:Equipment Design; D057809:HEK293 Cells; D006801:Humans; D008670:Metals / Q000737:chemistry*; D008856:Microscopy, Fluorescence / Q000295:instrumentation*; D057054:Molecular Imaging; D010087:Oxides; D012666:Semiconductors
chemical_list: D008670:Metals; D010087:Oxides