title: Compound K is able to ameliorate the impaired cognitive function and hippocampal neurogenesis following chemotherapy treatment.
abstract: Chemotherapy frequently results in neurocognitive deficits that include impaired learning and memory. Thus, it is important to prevent or ameliorate the persistence of cognitive impairment. Compound K was employed to examine the ameliorating effect on chronic treatment with cyclophosphamide. Eight week-old ICR mice were given 80 mg/kg cyclophosphamide, cyclophosphamide combined with compound K (2.5, 5 and 10 mg/kg) or saline injections once per week for 4 weeks. Passive avoidance test and Y maze were used to evaluate memory and learning ability. Immunohistochemical staining for progenitor cell and immature neurons was used to assess changes in neurogenesis. Compound K (10 mg/kg) is able to ameliorate the decrease of neurogenesis in the hippocampus caused by cyclophosphamide. These results suggest that compound K might be a potential strategy to ameliorate or repair the disrupted hippocampal neurogenesis induced by the side effect of chemotherapy agent.
authors.affiliation: Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, Taejon, Republic of Korea.
authors.forename: Jin-Gang
authors.initials: JG
authors.lastname: Hou
authors.forename: Jian-Jie
authors.initials: JJ
authors.lastname: Xue
authors.forename: Mi-Ra
authors.initials: MR
authors.lastname: Lee
authors.forename: Meng-Qi
authors.initials: MQ
authors.lastname: Sun
authors.forename: Xing-Hua
authors.initials: XH
authors.lastname: Zhao
authors.forename: Yi-Nan
authors.initials: YN
authors.lastname: Zheng
authors.forename: Chang-Keun
authors.initials: CK
authors.lastname: Sung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000494:pharmacology; D003072:Cognition Disorders / Q000139:chemically induced / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000494:pharmacology; D004195:Disease Models, Animal; D036145:Ginsenosides / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018782:Maze Learning; D008568:Memory / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D003520:Cyclophosphamide; D036145:Ginsenosides; C112772:ginsenoside compound K