title: Mechanical models for the self-organization of tubular patterns.
abstract: Organogenesis, such as long tubule self-organization, requires long-range coordination of cell mechanics to arrange cell positions and to remodel the extracellular matrix. While the current mainstream in the field of tissue morphogenesis focuses primarily on genetics and chemical signaling, the influence of cell mechanics on the programming of patterning cues in tissue morphogenesis has not been adequately addressed. Here, we review experimental evidence and propose quantitative mechanical models by which cells can create tubular patterns.
authors.affiliation: Department of Bioengineering; California Institute of Technology; Pasadena, CA USA.
authors.forename: Chin-Lin
authors.initials: CL
authors.lastname: Guo
mesh_terms: D000465:Algorithms; D000818:Animals; D001696:Biomechanical Phenomena / Q000502:physiology; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology; D008954:Models, Biological; D038081:Organogenesis
keywords: extracellular matrix; mechanical force; mechanics; morphogenesis; pattern formation; self-organization; tissues