title: [A case of meningeal disseminated sarcoidosis with marked hypoglycorrhachia in the CSF].
abstract: A 29-year-old man diagnosed as having pulmonary sarcoidosis in 2008, and hypothyroidism secondary to thyroidectomy for Basedow's disease was admitted to our hospital with pustular psoriasis in November 2010. He experienced high fever (38°C) and headache in late October 2010. Gadolinium-enhanced T1-weighted image showed multiple micronodular lesions with leptomeningeal enhancement, mainly in the brainstem. Cerebrospinal fluid (CSF) analysis revealed pleocytosis, raised protein level and hypoglycorrhachia (7 mg/dl). The patient was also found to have osteonecrosis of the left femoral head. Antituberculous treatment and steroid pulse therapy were started, but produced no improvement of either the symptoms or the laboratory data. Finally, the patient was diagnosed as having meningeal disseminated sarcoidosis by meningeal biopsy in late March 2011. He was started on treatment with 60 mg prednisolone per day, which resulted in marked clinical improvement. It should be borne in mind that marked hypoglycorrhachia in the CSF can also be seen in meningeal disseminated sarcoidosis.
authors.affiliation: Section of Internal Medicine, Japanese Red Cross Nagasaki Genbaku Hospital.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Mukaino
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kinoshita
authors.forename: Misachi
authors.initials: M
authors.lastname: Asai
authors.forename: Fumi
authors.initials: F
authors.lastname: Toriyama
authors.forename: Ruka
authors.initials: R
authors.lastname: Nakata
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Motomura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsuo
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D002241:Carbohydrates / Q000134:cerebrospinal fluid*; D002555:Cerebrospinal Fluid; D006801:Humans; D008297:Male; D008578:Meninges / Q000473:pathology*; D012507:Sarcoidosis / Q000134:cerebrospinal fluid* / Q000473:pathology
chemical_list: D002241:Carbohydrates