title: Pathogenicity, host responses and implications for management of enterohemorrhagic Escherichia coli O157:H7 infection.
abstract: Enterohemorrhagic Escherichia coli serotype O157:H7 is a food- and waterborne pathogen that causes significant morbidity and mortality in both developing and industrialized nations. The present review focuses on the history, epidemiology and evolution of the pathogen; provides a mechanistic overview of major virulence factors (including Shiga toxins, locus of enterocyte effacement pathogenicity island and pO157 plasmid); discusses host immune responses to infection; considers available animal models; and provides an overview of current and potential future management considerations.
authors.affiliation: Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Nathan K
authors.initials: NK
authors.lastname: Ho
authors.forename: Aleah C
authors.initials: AC
authors.lastname: Henry
authors.forename: Kathene
authors.initials: K
authors.lastname: Johnson-Henry
authors.forename: Philip M
authors.initials: PM
authors.lastname: Sherman
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology / Q000628:therapy*; D019453:Escherichia coli O157 / Q000276:immunology / Q000472:pathogenicity*; D029968:Escherichia coli Proteins / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D010750:Phosphoproteins / Q000378:metabolism; D010957:Plasmids; D022603:Shiga Toxins / Q000378:metabolism
chemical_list: D029968:Escherichia coli Proteins; C457340:LEE protein, E coli; D010750:Phosphoproteins; D022603:Shiga Toxins