title: Effect of carbonation on brain processing of sweet stimuli in humans.
abstract: Little is known about how CO2 affects neural processing of taste. We used functional magnetic resonance imaging to investigate the effects of carbonation on brain processing of sweet stimuli, which has relevance to studies of food selection and satiety. The presence of carbonation produced an overall decrease in the neural processing of sweetness-related signals, especially from sucrose. CO2 reduced the neural processing of sucrose more than that of artificial sweeteners. These findings might be relevant to dietary interventions that include noncaloric beverages, whereas the combination of CO2 and sucrose might increase consumption of sucrose.
authors.affiliation: Department of Medicine, Salerno University, Salerno, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Salle
authors.forename: Elena
authors.initials: E
authors.lastname: Cantone
authors.forename: Maria Flavia
authors.initials: MF
authors.lastname: Savarese
authors.forename: Adriana
authors.initials: A
authors.lastname: Aragri
authors.forename: Anna
authors.initials: A
authors.lastname: Prinster
authors.forename: Emanuele
authors.initials: E
authors.lastname: Nicolai
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sarnelli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Iengo
authors.forename: Maxime
authors.initials: M
authors.lastname: Buyckx
authors.forename: Rosario
authors.initials: R
authors.lastname: Cuomo
mesh_terms: D001218:Aspartame / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000494:pharmacology*; D002253:Carbonated Beverages; D006801:Humans; D008279:Magnetic Resonance Imaging; D013395:Sucrose / Q000494:pharmacology*; D013549:Sweetening Agents / Q000494:pharmacology*; D055697:Taste Perception / Q000187:drug effects*; D013843:Thiazines / Q000494:pharmacology*
chemical_list: D013549:Sweetening Agents; D013843:Thiazines; D002245:Carbon Dioxide; D013395:Sucrose; C006362:acetosulfame; D001218:Aspartame
keywords: AI; Amy; As-Ac; Beverage Consumption; Brain; Gustatory System; OFC; amygdala; anterior insula; aspartame and acesulfame; fMRI; orbitofrontal cortex