title: Synthetically engineered rpb1 alleles altering RNA polymerase II carboxy terminal domain phosphorylation induce discrete morphogenetic defects in Schizosaccharomyces pombe.
abstract: In this report the phenotypic effects of systematic site-directed mutations in the fission yeast RNA pol II carboxy terminal domain (CTD) are investigated. Remarkably, we find that alterations in CTD structure and/or phosphorylation result in distinct phenotypic changes related to morphogenetic control. A hypothesis based upon the concepts of "informational entropy" and "algorithmic transformation" is developed to explicate/rationalize these results.
authors.affiliation: Department of Biology; University of Western Ontario; London, ON Canada.
authors.forename: Kyle
authors.initials: K
authors.lastname: Hoffman
authors.forename: Haeyoung
authors.initials: H
authors.lastname: Yoo
authors.forename: Jim
authors.initials: J
authors.lastname: Karagiannis
keywords: RNA polymerase II; algorithmic transformation; carboxy terminal domain; cell division; fission yeast; morphogenesis