title: The role of interleukin-17A in colorectal tumorigenesis.
abstract: It has been well documented that interleukin (IL)-17A mainly produced by the newly identified T cell subtype Th17 cells is an important proinflammatory cytokine that plays a vital pathogenic role in the process of human inflammatory bowel diseases. Recently, new information concerning the biological activities of IL-17A relating to the development of colorectal cancer (CRC) has also been reported. The present mini-review focuses on recent observations concerning the role of IL-17A in the development of CRCs, and it discusses the clinical significance of IL-17A as a biomarker and potential therapeutic target.
authors.affiliation: Department of Gastroenterology, The Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Yingpeng
authors.initials: Y
authors.lastname: Shi
authors.forename: Hui
authors.initials: H
authors.lastname: Lin
authors.forename: Jing
authors.initials: J
authors.lastname: Cui
authors.forename: Haili
authors.initials: H
authors.lastname: Qi
authors.forename: Jon
authors.initials: J
authors.lastname: Florholmen
authors.forename: Zhanju
authors.initials: Z
authors.lastname: Liu
authors.forename: Guanglin
authors.initials: G
authors.lastname: Cui
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D063646:Carcinogenesis; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000235:genetics / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D020381:Interleukin-17