title: Mapping and cracking sensorimotor circuits in genetic model organisms.
abstract: One central goal of systems neuroscience is to understand how neural circuits implement the computations that link sensory inputs to behavior. Work combining electrophysiological and imaging-based approaches to measure neural activity with pharmacological and electrophysiological manipulations has provided fundamental insights. More recently, genetic approaches have been used to monitor and manipulate neural activity, opening up new experimental opportunities and challenges. Here, we discuss issues associated with applying genetic approaches to circuit dissection in sensorimotor transformations, outlining important considerations for experimental design and considering how modeling can complement experimental approaches.
authors.affiliation: Department of Neurobiology, 299 W. Campus Drive, Stanford University, Stanford, CA 94305, USA.
authors.forename: Damon A
authors.initials: DA
authors.lastname: Clark
authors.forename: Limor
authors.initials: L
authors.lastname: Freifeld
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Clandinin
mesh_terms: D000818:Animals; D001519:Behavior / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000378:metabolism; D023421:Models, Animal; D008957:Models, Genetic; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009434:Neural Pathways / Q000502:physiology*; D009488:Neurosciences / Q000379:methods; D010465:Perception / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012677:Sensation / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D049490:Systems Biology / Q000379:methods; D014158:Transcription, Genetic
chemical_list: D009419:Nerve Tissue Proteins