title: Effect of metformin on substrate utilization after exercise training in adults with impaired glucose tolerance.
abstract: Metformin attenuates the higher insulin sensitivity that occurs with exercise training. Sixteen people with prediabetes trained for 10 weeks while taking metformin (n = 8) or placebo (n = 8). Substrate utilization was assessed using glucose kinetics and indirect calorimetry. After training, exercise whole-body fat oxidation was higher and glycogen use lower (p < 0.05), with no differences between groups. Blood glucose use was unchanged. Training-induced enhancement of insulin sensitivity (clamp) correlated with higher peak oxygen uptake (r = 0.70; p < 0.05), but was independent of glucose kinetic and substrate metabolism.
authors.affiliation: Energy Metabolism Laboratory, Department of Kinesiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA.
authors.forename: Steven K
authors.initials: SK
authors.lastname: Malin
authors.forename: Barry
authors.initials: B
authors.lastname: Braun
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015444:Exercise; D005947:Glucose / Q000378:metabolism; D018149:Glucose Intolerance; D006801:Humans; D007328:Insulin / Q000097:blood; D008687:Metformin
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008687:Metformin; D005947:Glucose