title: Melatonin-based therapeutics for neuroprotection in stroke.
abstract: The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell therapy in stroke, implicating the role of melatonin receptors. As we envision the clinical entry of melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application.
authors.affiliation: Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA. cborlong@health.usf.edu.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Shinozuka
authors.forename: Meaghan
authors.initials: M
authors.lastname: Staples
authors.forename: Cesar V
authors.initials: CV
authors.lastname: Borlongan
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D008550:Melatonin / Q000494:pharmacology / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D010870:Pineal Gland / Q000637:transplantation; D013234:Stem Cells / Q000187:drug effects; D020521:Stroke / Q000188:drug therapy*
chemical_list: D018696:Neuroprotective Agents; D008550:Melatonin