title: Processed Panax ginseng, Sun Ginseng Increases Type I Collagen by Regulating MMP-1 and TIMP-1 Expression in Human Dermal Fibroblasts.
abstract: In the present study, effects of sun ginseng (SG) on the collagen synthesis and the proliferation of dermal fibroblast were investigated. Collagen synthesis was measured by assaying procollagen type I C-peptide production. In addition, the level of matrix metalloproteinase (MMP)-1 was assessed by western blot analysis. SG suppressed the MMP-1 protein level in a dose-dependent manner. In contrast, SG dose-dependently increased tissue inhibitors of MMP (TIMP)-1 production in fibroblasts. SG increased type I collagen production directly and/or indirectly by reducing MMP-1 and stimulating TIMP-1 production in human dermal fibroblasts. SG dose-dependently induced fibroblast proliferation and this, in turn, can trigger more collagen production. These results suggest that SG may be a potential pharmacological agent with anti-aging properties in cultured human skin fibroblast.
authors.affiliation: Lab of Cell Differentiation Research, College of Oriental Medicine, Gachon University, Seongnam 461-701, Korea.
authors.forename: Kyu Choon
authors.initials: KC
authors.lastname: Song
authors.forename: Tong-Shin
authors.initials: TS
authors.lastname: Chang
authors.forename: Hyejin
authors.initials: H
authors.lastname: Lee
authors.forename: Jinhee
authors.initials: J
authors.lastname: Kim
authors.forename: Jeong Hill
authors.initials: JH
authors.lastname: Park
authors.forename: Gwi Seo
authors.initials: GS
authors.lastname: Hwang
keywords: Human skin fibroblasts; Matrix metalloproteinase-1; Panax ginseng; Sun ginseng (SE); Type I collagen