title: Evaluation of tumor response to systemic therapy in hepatocellular carcinoma.
abstract: Evaluation of tumor response (the change in tumor volume) represents the basis for assessing therapeutic efficacy. Furthermore, objective response and progression are endpoints in clinical trials. Response Evaluation Criteria in Solid Tumors (RECIST) is an assessment tool derived from the conversion of quantitative imaging observations. Version 1.1 has been validated and its criteria are useful in all studies intended to assess objective response, disease stabilization and tumor progression, or time to progression analysis. In addition to changes regarding the disease assessment criteria of measurable and non-measurable lesions, the new system integrates volumetric assessment and functional imaging. The REC1ST's utility system follows from the applicability in clinical trials and the possible use in clinical practice. However, adapting it to assess liver tumors requires evaluation in prospective trials.
authors.affiliation: University of Medicine and Pharmacy Grigore T Popa Iasi, Faculty of Medicine.
authors.forename: B
authors.initials: B
authors.lastname: Gafton
authors.forename: Simona
authors.initials: S
authors.lastname: Pârciu
authors.forename: Elena
authors.initials: E
authors.lastname: Murguleţ
authors.forename: G
authors.initials: G
authors.lastname: Bălan
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology*; D002986:Clinical Trials as Topic; D018450:Disease Progression; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology*; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012383:Romania / Q000453:epidemiology; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents