title: Genomic mosaicism in two strains of Dengue virus type 3.
abstract: Recombination is a significant factor driving genomic evolution, but it is not well understood in Dengue virus. We used phylogenetic methods to search for recombination in 636 Dengue virus type 3 (DENV-3) genomes and unveiled complex recombination patterns in two strains, which appear to be the outcome of recombination between genotype II and genotype I parental DENV-3 lineages. Our findings of genomic mosaic structures suggest that strand switching during RNA synthesis may be involved in the generation of genetic diversity in dengue viruses.
authors.affiliation: Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1734, CEP: 05508-000, São Paulo, SP, Brazil.
authors.forename: Christian Julián
authors.initials: CJ
authors.lastname: Villabona-Arenas
authors.forename: Anderson Fernandes
authors.initials: AF
authors.lastname: de Brito
authors.forename: Paolo Marinho
authors.initials: PM
authors.lastname: de Andrade Zanotto
mesh_terms: D001499:Bayes Theorem; D003716:Dengue Virus / Q000145:classification / Q000235:genetics*; D019143:Evolution, Molecular; D016679:Genome, Viral; D010802:Phylogeny; D011995:Recombination, Genetic
keywords: Dengue virus type 3; Phylogeny; Recombination; Split decomposition