title: Breast cancer mortality in participants of the Norwegian Breast Cancer Screening Program.
abstract: BACKGROUND
  The Norwegian Breast Cancer Screening Program started in 1996. To the authors' knowledge, this is the first report using individual-based data on invitation and participation to analyze breast cancer mortality among screened and nonscreened women in the program.
  
  
  METHODS
  Information on dates of invitation, attendance, breast cancer diagnosis, emigration, death, and cause of death was linked by using unique 11-digit personal identification numbers assigned all inhabitants of Norway at birth or immigration. In total, 699,628 women ages 50 to 69 years without prior a diagnosis of breast cancer were invited to the program from 1996 to 2009 and were followed for breast cancer through 2009 and death through 2010. Incidence-based breast cancer mortality rate ratios (MRRs) were compared between the screened and nonscreened cohorts using a Poisson regression model. The MRRs were adjusted for calendar period, attained age, years since inclusion in the cohorts, and self-selection bias.
  
  
  RESULTS
  The crude breast cancer mortality rate was 20.7 per 100,000 women-years for the screened cohort compared with 39.7 per 100,000 women-years for the nonscreened cohort, resulting in an MRR of 0.52 (95% confidence interval, 0.47-0.59). The mortality reduction associated with attendance in the program was 43% (MRR, 0.57; 95% confidence interval, 0.51-0.64) after adjusting for calendar period, attained age, years after inclusion in the cohort, and self-selection bias.
  
  
  CONCLUSIONS
  After 15 years of follow-up, a 43% reduction in mortality was observed among women who attended the national mammographic screening program in Norway.
authors.affiliation: Department of Research, Cancer Registry of Norway, Oslo, Norway; Oslo and Akershus University College of Applied Sciences, Oslo, Norway.
authors.forename: Solveig
authors.initials: S
authors.lastname: Hofvind
authors.forename: Giske
authors.initials: G
authors.lastname: Ursin
authors.forename: Steinar
authors.initials: S
authors.lastname: Tretli
authors.forename: Sofie
authors.initials: S
authors.lastname: Sebuødegård
authors.forename: Bjørn
authors.initials: B
authors.lastname: Møller
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000401:mortality* / Q000517:prevention & control; D015331:Cohort Studies; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008327:Mammography; D008403:Mass Screening; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D012042:Registries; D015983:Selection Bias; D015996:Survival Rate
keywords: Norway/epidemiology; breast neoplasms/mortality; breast neoplasms/prevention and control; breast neoplasms/radiography; female; mammography; mass screening