title: Evaluation of the biocompatibility of resin-based root canal sealers in rat periapical tissue.
abstract: We evaluated the biocompatibility of resin-based root canal sealers (RCSs) in the periapical tissues of rats. Wistar rats underwent tooth replantation for reproducing the response of periapical tissue with RCSs. The resin-based Epipany SE, AH Plus Jet, the eugenol-based sealer (Canals) and a control group were employed. The upper right first molar was extracted and applied with RCSs on apices, and then the tooth was repositioned. Histological evaluation demonstrated that mild inflammation occurred in the periapical tissue with Epiphany and AH Plus Jet sealers on day 7, whereas Canals induced severe-to-moderate inflammation. The statistical analyses demonstrated that the significant differences were observed between Canals and the other groups on day 7 regarding inflammatory response. On day 14, the lesions induced by all sealers were healed and replaced predominantly by fibrous connective tissue. Our results suggest that Epiphany SE and AH Plus Jet are good biocompatible materials.
authors.affiliation: Department of Oral Medicine, Division of Endodontics, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka 238-8580, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Mutoh
authors.forename: Takenori
authors.initials: T
authors.lastname: Satoh
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Watabe
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Tani-Ishii
mesh_terms: D000818:Animals; D003739:Dental Cementum / Q000187:drug effects; D003804:Dentin / Q000187:drug effects; D004853:Epoxy Resins / Q000737:chemistry / Q000633:toxicity*; D005260:Female; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry / Q000633:toxicity*; D023421:Models, Animal; D010486:Periapical Tissue / Q000187:drug effects*; D010513:Periodontal Ligament / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000737:chemistry / Q000633:toxicity*; D015035:Zinc Oxide-Eugenol Cement / Q000633:toxicity
chemical_list: D004853:Epoxy Resins; D008689:Methacrylates; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; C112894:canals sealer; C486893:epiphany sealer; C534916:epoxy resin-based root canal sealer