title: Chromosomal Arrangement of AHL-Driven Quorum Sensing Circuits in Pseudomonas.
abstract: Pseudomonas spp. are able to colonize a large variety of environments due to their wide adaptability which is also associated with an N-acyl homoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). In this article we present a systematic overview of the genomic arrangement patterns of quorum sensing genes found in Pseudomonas and compare the topologies with those found in other bacterial genomes. We find that the topological arrangement of QS genes is more variable than previously thought but there are a few unifying features that occur in many of the topological arrangements. We hypothesize that the negative regulators of QS that are often found between the canonical luxR/ and luxI-family genes may be crucial for stabilizing the output of QS circuits.
authors.affiliation: Faculty of Information Technology, Pázmány Péter Catholic University, Práter u. 50/a, 1083 Budapest, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Gelencsér
authors.forename: Borisz
authors.initials: B
authors.lastname: Galbáts
authors.forename: Juan F
authors.initials: JF
authors.lastname: Gonzalez
authors.forename: K Sonal
authors.initials: KS
authors.lastname: Choudhary
authors.forename: Sanjarbek
authors.initials: S
authors.lastname: Hudaiberdiev
authors.forename: Vittorio
authors.initials: V
authors.lastname: Venturi
authors.forename: Sándor
authors.initials: S
authors.lastname: Pongor