title: Upper reference limits of high-sensitivity cardiac troponin T in a general population: comparison with those of sensitive cardiac troponin I.
abstract: BACKGROUND
  Upper reference limits (97.5th, 99th percentiles) of high-sensitivity and sensitive cardiac troponins (hs-cTn and s-cTn) can be influenced by several factors. Our aim was to study: (1) the ability of hs-cTnT and s-cTnI to detect circulating cTn in a general community population, and (2) the effects of age, renal function, and gender on their 97.5th - 99th percentile values.
  
  
  METHODS
  Hs-cTnT and s-cTnI values were measured in 177 subjects.
  
  
  RESULTS
  Thirty-six subjects (20%) presented hs-cTnT values above the limit of detection (LoD), whereas no subjects presented detectable s-cTnI values. Men presented more frequently than women with detectable hs-cTnT levels (37% vs. 11%; p = 0.0001). Hs-cTnT was more frequently found in older (> or = 70 years) than in younger subjects (57 vs. 14%; p < 0.0001). Subjects with low estimated glomerular filtration rates (eGFR < 60 mL/min1/ 1.73m2) presented more frequently with detectable hs-cTnT levels than subjects with higher eGFR (71% vs. 17%; p < 0.0001). Hs-cTnT 97.5th - 99th percentiles varied according to selection by age, renal function, and gender; percentile values of s-cTnI were below the LoD of the assay.
  
  
  CONCLUSIONS
  Hs-cTnT is more often quantified than s-cTnI in healthy subjects. Age, gender, and eGFR values influence 97.5th - 99th hs-cTnT percentile values.
authors.affiliation: Clinical Chemistry Laboratory, Cochin and Hôtel-Dieu Hospitals, Assistance Publique des Hôpitaux de Paris (APHP), France. camille.gobeaux@cch.aphp.fr
authors.forename: Camille
authors.initials: C
authors.lastname: Chenevier-Gobeaux
authors.forename: Sophie
authors.initials: S
authors.lastname: Bailleul
authors.forename: Alexandre
authors.initials: A
authors.lastname: Mzabi
authors.forename: Marie-Céline
authors.initials: MC
authors.lastname: Blanc
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lefevre
mesh_terms: D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D057230:Limit of Detection; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood*
chemical_list: D019210:Troponin I; D020107:Troponin T