title: Obese subjects have significantly higher serum prooxidantantioxidant balance values compared to normal-weight subjects.
abstract: BACKGROUND
  It has been reported that obesity is associated with higher levels of oxidative stress. We aimed to evaluate the hypothesis that pro-oxidant antioxidant balance (PAB) values could be affected by adiposity and to assess the association between PAB levels and indices of obesity.
  
  
  METHODS
  Subjects (n = 733) were recruited and tlen were divided into 3 groups of normal-weight (BMI < 25, n = 207), overweight (25 < BMI < 30, n = 375), and obese (BMI > 30, n = 151). PAB values were measured in all participants.
  
  
  RESULTS
  There was a significant association between PAB values and weight when the correlation was determined for all subjects (p < 0.05). Obese subject had significantly higher levels of PAB values [40.8 (34.3 - 51.1) HK unit] compared with overweight [37.5 (29.7 - 47.3) HK unit] and normal-weight subjects [37.2 (29.6 - 45.2) HK unit] (p < 0.05 in each case). However, there was no significant difference in PAB values between normal and over-weight subjects (p > 0.05). On performing the analysis of covariance, low-density lipoprotein-cholesterol (LDL-C) was found to have a significant independent association with PAB values (j = 0.046, p = 0.04).
  
  
  CONCLUSIONS
  The high levels of PAB values in obese subjects without overt signs/symptoms of cardiovascular disease may be related to a heightened state of oxidative stress associated with obesity.
authors.affiliation: Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Akramosadat
authors.initials: A
authors.lastname: Razavi
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Baghshani
authors.forename: Hossein Mohaddes
authors.initials: HM
authors.lastname: Ardabili
authors.forename: Mohammad Sobhan Sheikh
authors.initials: MS
authors.lastname: Andalibi
authors.forename: Amir Ali
authors.initials: AA
authors.lastname: Rahsepar
authors.forename: Mohsen
authors.initials: M
authors.lastname: Moohebati
authors.forename: Mohsen
authors.initials: M
authors.lastname: Nematy
authors.forename: Shima
authors.initials: S
authors.lastname: Tavallaie
authors.forename: Somayeh
authors.initials: S
authors.lastname: Mousavi
authors.forename: Saeed
authors.initials: S
authors.lastname: Akhlaghi
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Gordon
authors.initials: G
authors.lastname: Ferns
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001835:Body Weight; D016022:Case-Control Studies; D006801:Humans; D008875:Middle Aged; D009765:Obesity; D017382:Reactive Oxygen Species / Q000097:blood*; D012016:Reference Values
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species