title: Translation of the ecological trap concept to glioma therapy: the cancer cell trap concept.
abstract: Viewing tumors as ecosystems offers the opportunity to consider how ecological concepts can be translated to novel therapeutic perspectives. The ecological trap concept emerged approximately half a century ago when it was observed that animals can prefer an environment of low quality for survival over other available environments of higher quality. The presence of such a trap can drive a local population to extinction. The cancer cell trap concept is the translation of the ecological trap into glioma therapy. It exploits and diverts the invasive potential of glioma cells by guiding their migration towards specific locations where a local therapy can be delivered efficiently. This illustrates how an ecological concept can change therapeutic obstacles into therapeutic tools.
authors.affiliation: INSERM U836, Grenoble Institut des Neurosciences, Université Joseph Fourier, CHU Michallon, Grenoble, France.
authors.forename: Boudewijn
authors.initials: B
authors.lastname: van der Sanden
authors.forename: Florence
authors.initials: F
authors.lastname: Appaix
authors.forename: François
authors.initials: F
authors.lastname: Berger
authors.forename: Laurent
authors.initials: L
authors.lastname: Selek
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Issartel
authors.forename: Didier
authors.initials: D
authors.lastname: Wion
mesh_terms: D000818:Animals; D005910:Glioma / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy; D059016:Tumor Microenvironment