title: Engineering microbial cells for the biosynthesis of natural compounds of pharmaceutical significance.
abstract: Microbes constitute important platforms for the biosynthesis of numerous molecules of pharmaceutical interest such as antitumor, anticancer, antiviral, antihypertensive, antiparasitic, antioxidant, immunological agents, and antibiotics as well as hormones, belonging to various chemical families, for instance, terpenoids, alkaloids, polyphenols, polyketides, amines, and proteins. Engineering microbial factories offers rich opportunities for the production of natural products that are too complex for cost-effective chemical synthesis and whose extraction from their originating plants needs the use of many solvents. Recent progresses that have been made since the millennium beginning with metabolic engineering of microorganisms for the biosynthesis of natural products of pharmaceutical significance will be reviewed.
authors.affiliation: Laboratory of Enology and Applied Chemistry, Research Unit on Vines and Wines in Champagne, UPRES EA 4707, Faculty of Sciences, University of Reims, P.O. Box 1039, 51687 Reims Cedex 02, France. philippe.jeandet@univ-reims.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Jeandet
authors.forename: Yann
authors.initials: Y
authors.lastname: Vasserot
authors.forename: Thomas
authors.initials: T
authors.lastname: Chastang
authors.forename: Eric
authors.initials: E
authors.lastname: Courot
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis; D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D001419:Bacteria / Q000737:chemistry / Q000378:metabolism*; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D019149:Bioreactors; D060846:Cell Engineering; D005818:Genetic Engineering; D006801:Humans; D061065:Polyketides / Q000737:chemistry / Q000378:metabolism; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D001688:Biological Products; D061065:Polyketides; D013729:Terpenes