title: Photosensitizer and light diffusion through dentin in photodynamic therapy.
abstract: Photodynamic therapy has been considered a potential antimicrobial modality against oral infections, including dental caries. A model to estimate the penetration of both photosensitizers and light through human dentin, a factor of interest in photodynamic therapy, is proposed. The photoacoustic spectroscopy technique was used to evaluate in vitro dentin permeability of three different photosensitizers. Using the dentin optical absorption and scattering coefficients, it was possible to propose a semi-quantitative model predicting both photosensitizer and light doses within dentin. The graphic illustrations obtained provided guidelines that may be useful in photodynamic therapy protocols used as antimicrobial tools in caries lesions.
authors.affiliation: State University of Maringá, Department of Physics, Avenue Colombo 5790, 87020-900, Maringá, Paraná, Brazil.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Nogueira
authors.forename: Ariane X
authors.initials: AX
authors.lastname: Graciano
authors.forename: Juliana Y
authors.initials: JY
authors.lastname: Nagata
authors.forename: Mitsue
authors.initials: M
authors.lastname: Fujimaki
authors.forename: Raquel S S
authors.initials: RS
authors.lastname: Terada
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Bento
authors.forename: Nelson G C
authors.initials: NG
authors.lastname: Astrath
authors.forename: Mauro L
authors.initials: ML
authors.lastname: Baesso
mesh_terms: D003804:Dentin / Q000737:chemistry*; D004058:Diffusion; D006801:Humans; D008963:Molar / Q000737:chemistry; D061088:Photoacoustic Techniques / Q000379:methods*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry; D013057:Spectrum Analysis / Q000379:methods*; D014048:Tolonium Chloride / Q000737:chemistry
chemical_list: D017319:Photosensitizing Agents; D014048:Tolonium Chloride