title: A new and practical method for the synthesis of 6-aryl-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(₃Η,8Η)-diones.
abstract: A one step general synthetic methodology for the synthesis of 6-aryl-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-diones (17{[Formula: see text]} ([Formula: see text]) and 20{[Formula: see text]} ([Formula: see text])) is described. This methodology is based on reacting a 2-aryl-substituted acrylate (16{[Formula: see text]}) with the corresponding 6-aminopyrimidin-4(3[Formula: see text]-one (13 ([Formula: see text]; 19 ([Formula: see text])) in presence of a base under microwave irradiation. The resulting pyrido[2,3-[Formula: see text]]pyrimidines present an aryl substituent at position C6, precisely the one directly related to the biological activity of such heterocycles. These protocols have been extended to other 2-alkyl-substituted and 3-alkyl (or aryl)-substituted acrylates but with lower yields.
authors.affiliation: Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta, 390, 08017 , Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Camarasa
authors.forename: Christian
authors.initials: C
authors.lastname: Barnils
authors.forename: Raimon
authors.initials: R
authors.lastname: Puig de la Bellacasa
authors.forename: Jordi
authors.initials: J
authors.lastname: Teixidó
authors.forename: José I
authors.initials: JI
authors.lastname: Borrell
mesh_terms: D000179:Acrylates / Q000737:chemistry; D015195:Drug Design; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000179:Acrylates; D006574:Heterocyclic Compounds, 2-Ring; D011728:Pyridones; D011743:Pyrimidines; D011744:Pyrimidinones