title: Signal-dependent Elk-1 target genes involved in transcript processing and cell migration.
abstract: Elk-1 was regarded as a transcription factor engaged mainly in the regulation of cell growth, differentiation, and survival. Recent findings show the engagement of Elk-1 in the control of expression of genes encoding proteins involved in transcript turnover, such as MCPIP1/ZC3H12A and tristetraprolin (TTP/ZFP36). Thus, Elk-1 plays an important role in the control of gene expression not only through the stimulation of expression of transcription factors, but also through regulation of transcript half-live. Moreover, Elk-1 is engaged in the regulation of expression of genes encoding proteins that control proteolytic activity, such as inhibitor of plasminogen activator-1 (PAI-1) and metalloproteinases-2 and -9 (MMP-2 and MMP-9). This review summarizes the biological roles of proteins with expression regulated by Elk-1, involved in transcripts turnover or in cell migration. The broad range of function of these proteins illustrates the complex role of Elk-1 in the regulation of cancer and inflammation.
authors.affiliation: Department of Cell Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland. Electronic address: aneta.kasza@uj.edu.pl.
authors.forename: Aneta
authors.initials: A
authors.lastname: Kasza
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D015398:Signal Transduction; D014158:Transcription, Genetic / Q000235:genetics*; D050807:ets-Domain Protein Elk-1 / Q000235:genetics* / Q000378:metabolism
chemical_list: D050807:ets-Domain Protein Elk-1
keywords: Cancer; Elk-1; MCPIP1; MMPs; PAI-1; Tristetraprolin