title: A Case of Hypocalcemia with Severe Vitamin D Deficiency following Treatment for Graves' Disease with Methimazole.
abstract: We herein report the case of a 41-year-old Japanese female office worker who developed symptomatic hypocalcemia with severe vitamin D deficiency following treatment for Graves' disease with methimazole. The patient's hypocalcemia was mainly caused by vitamin D deficiency due to unbalanced diets and inadequate exposure to sunlight in addition to the resolution of hyperthyroidism. Vitamin D deficiency is increasing worldwide, and it has been more recently shown to relate to the pathogenesis of Graves' disease. However, vitamin D deficiency as a cause of hypocalcemia has received little attention. Taken together, this case suggests that we should take more care in calcium kinetics and vitamin D status during treatment for Graves' disease with antithyroid drugs.
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Miyashita
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Yasuda
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.forename: Akio
authors.initials: A
authors.lastname: Kuroda
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Kitamura
authors.forename: Michio
authors.initials: M
authors.lastname: Otsuki
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Noboru
authors.initials: N
authors.lastname: Hamada
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura