title: Effect of resistance training on plasma nitric oxide and asymmetric dimethylarginine concentrations in type I diabetic rats.
abstract: BACKGROUND
  Asymmetric dimethylarginine (ADMA) has a predominant role in progression of some cardiovascular diseases, including diabetes. It interferes with L-arginine in production of nitric oxide (NO) by inhibition of NO synthase. The purpose of this study was to evaluate the effect of resistance training on plasma NO and ADMA concentrations in type 1 diabetic male rats.
  
  
  METHODS
  Thirty-six male wistar rats were randomly divided into four groups: (1) control; (2) diabetic; (3) diabetic trained, and (4) control trained (n = 9 each). In the trained groups, the animals undertook one training session per day, 3 days/week, for 4 weeks. At the end of experiment, blood samples were taken and the concentrations of plasma glucose, insulin, lipid profile, NO and ADMA concentrations were determined.
  
  
  RESULTS
  plasma ADMA concentration showed a significant increase in diabetic rats compare to control group (0.73 ± 0.07 vs. 0.62 ± 0.04 μmol/l; P < 0.05). The plasma ADMA level in the trained diabetic and control were lower than the sedentary groups, although it was not statistically significant. Plasma NO concentration in diabetic group was lower than control (P < 0.05). Resistance training significantly increased plasma NO concentration in diabetic animals (P < 0.05).
  
  
  CONCLUSIONS
  Elevated ADMA level in diabetic animals can normalize during resistance exercise. Reduced ADMA level and increased NO level following resistance training might improve cardiovascular risk in diabetic subjects.
authors.affiliation: Department of Physical Education and Sports, Tarbiat Modarres University, Tehran, Iran ; School Management and Medical Informatics, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Parivash Shekarchizadeh
authors.initials: PS
authors.lastname: Esfahani
authors.forename: Reza
authors.initials: R
authors.lastname: Gharakhanlou
authors.forename: Jahangir
authors.initials: J
authors.lastname: Karimian
authors.forename: Majid
authors.initials: M
authors.lastname: Khazaei
authors.forename: Awat
authors.initials: A
authors.lastname: Feizi
authors.forename: Alireza
authors.initials: A
authors.lastname: Safarzade
keywords: Asymmetric dimethylarginine; diabetes; nitric oxide; resistance training