title: Correlation between preoperative systemic inflammation and postoperative infection in patients with gastrointestinal cancer: a multicenter study.
abstract: OBJECTIVE
  Our aim was to examine the association between postoperative infection and preoperative systemic inflammation in patients undergoing resection of gastrointestinal cancer.
  
  
  METHODS
  We studied 862 patients who underwent elective gastrointestinal cancer surgery at six institutions. The levels of C-reactive protein and albumin were included as parameters of preoperative systemic inflammation measured using the Glasgow prognostic score. The Glasgow prognostic score was calculated based on the admission data as follows: patients with an elevated level of C-reactive protein (>1.0 mg/dl) and hypoalbuminemia (<3.5 g/dl) were allocated a score of 2, while patients showing one or none of these blood chemistry abnormalities were allocated a score of 1 or 0, respectively. The significance of the Glasgow prognostic score for predicting postoperative infection was analyzed using a multivariate analysis.
  
  
  RESULTS
  After surgery, 182 (21 %) patients developed postoperative infections. According to a multivariate analysis, the Glasgow prognostic score (p < 0.01) was independently associated with an increased risk of developing a postoperative infection. When the postoperative infections were divided into surgical site infections and remote site infections, the Glasgow prognostic score was significantly associated with an increased risk of developing remote site infections.
  
  
  CONCLUSIONS
  Preoperative systemic inflammation is associated with postoperative infection in patients undergoing resection of gastrointestinal cancer.
authors.affiliation: Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 5148507, Japan, ya-mohri@clin.medic.mie-u.ac.jp.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Mohri
authors.forename: Chikao
authors.initials: C
authors.lastname: Miki
authors.forename: Minako
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Okita
authors.forename: Mikihiro
authors.initials: M
authors.lastname: Inoue
authors.forename: Keiichi
authors.initials: K
authors.lastname: Uchida
authors.forename: Koji
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Inoue
authors.forename: Masato
authors.initials: M
authors.lastname: Kusunoki
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D013505:Digestive System Surgical Procedures; D017558:Elective Surgical Procedures; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000601:surgery*; D006801:Humans; D034141:Hypoalbuminemia; D007239:Infections / Q000453:epidemiology* / Q000209:etiology; D007249:Inflammation / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology; D057234:Preoperative Period; D011379:Prognosis; D012189:Retrospective Studies; D012306:Risk
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein