title: Cyclin B1 overexpression in conventional oral squamous cell carcinoma and verrucous carcinoma- A correlation with clinicopathological features.
abstract: BACKGROUND
  Nuclear localization of cyclin B1 is an indicator for cells undergoing mitotic division, and the overexpression has shown promising results as a good prognostic predictor for patients of squamous cell carcinoma (SCC). Cyclin B1 overexpression among histological grades of conventional oral squamous cell carcinoma (COSCC), as well as comparison with verrucous carcinoma (VC) has been less investigated.
  
  
  METHODS
  Immunohistochemical expression of cyclin B1 was compared with various clinicopathological features in 30 primary COSCC and 31 primary VC cases.
  
  
  RESULTS
  Cyclin B1 showed significant overexpression for some clinical features for both the variants of oral squamous cell carcinoma. In histopathological variants, statistical significance was observed among grades of COSCC, as well as COSCC and its grades with VC. The concomitant increase in cyclin B1 overexpression from VC to grades COSCC was observed.
  
  
  CONCLUSIONS
  Our study findings draw attention to cyclin B1 overexpression is involved in early carcinogenesis, cell differentiation and tumor proliferation.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Jodhpur national University, Jodhpur dental college and Hospital, Jodhpur, Rajasthan, India . drgururajpatil@gmail.com
authors.forename: Gururaj B
authors.initials: GB
authors.lastname: Patil
authors.forename: Kaveri S
authors.initials: KS
authors.lastname: Hallikeri
authors.forename: Aswini Y
authors.initials: AY
authors.lastname: Balappanavar
authors.forename: Sudheer G
authors.initials: SG
authors.lastname: Hongal
authors.forename: P R
authors.initials: PR
authors.lastname: Sanjaya
authors.forename: Sheetalkumar G
authors.initials: SG
authors.lastname: Sagari
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D018289:Carcinoma, Verrucous / Q000378:metabolism* / Q000473:pathology*; D003430:Cross-Sectional Studies; D056744:Cyclin B1 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D056744:Cyclin B1