title: The hemostatic effect of calcium alginate in experimental splenic injury model.
abstract: BACKGROUND
  We evaluated the effect of calcium alginate as a hemostatic agent in a splenic injury model.
  
  
  METHODS
  Experimental rats (Wistar albino) were divided into four groups. Group I: Laparotomy was not performed. Group II: After laparotomy, the abdomen was closed without any splenic injury. Group III: After laparotomy, splenic injury about 0.5 cm in depth and 0.3 cm in length was created by standard Rochester pean forceps. Physiological serum treated gauze dressing, about 2x2 cm in size, was applied to the injured splenic tissue for 3 minutes. Group IV: After laparotomy, standard splenic injury about 0.5 cm in length and 0.3 cm in depth was created. Calcium alginate wound dressing, 1x1 cm in size, was applied to the splenic wound. In all groups, blood samples for bleeding time and hemogram were taken. Peroperative blood loss, pre- and post-operative hemoglobin and hematocrit values were calculated.
  
  
  RESULTS
  Comparing hematocrit values and peroperative bleeding in Groups III and IV, Group IV had a lower decline in hematocrit values and lower peroperative bleeding.
  
  
  CONCLUSIONS
  Calcium alginate has hemostatic capacity. It may be used in splenic injuries, especially for Grades I and II.
authors.affiliation: Department of General Surgery, Düzce University Faculty of Medicine, Düzce, Turkey.
authors.forename: Ali Kemal
authors.initials: AK
authors.lastname: Taşkın
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yaşar
authors.forename: Ismet
authors.initials: I
authors.lastname: Ozaydın
authors.forename: Bülent
authors.initials: B
authors.lastname: Kaya
authors.forename: Orhan
authors.initials: O
authors.lastname: Bat
authors.forename: Seyit
authors.initials: S
authors.lastname: Ankaralı
authors.forename: Umran
authors.initials: U
authors.lastname: Yıldırım
authors.forename: Metin
authors.initials: M
authors.lastname: Aydın
mesh_terms: D000007:Abdominal Injuries / Q000097:blood / Q000188:drug therapy*; D000464:Alginates / Q000494:pharmacology*; D000818:Animals; D001458:Bandages; D004195:Disease Models, Animal; D020723:Glucuronic Acid / Q000494:pharmacology; D006400:Hematocrit; D006470:Hemorrhage / Q000188:drug therapy* / Q000517:prevention & control*; D006490:Hemostatics / Q000494:pharmacology*; D006603:Hexuronic Acids / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000293:injuries*
chemical_list: D000464:Alginates; D006490:Hemostatics; D006603:Hexuronic Acids; D020723:Glucuronic Acid