title: Novel ultrafiltration technique for blood conservation in cardiac operations.
abstract: OBJECTIVE
  The performance characteristics and clinical outcome of a novel hemoconcentrator, the HemoSep (Brightwake, Nottingham, United Kingdom), for reusing salvaged blood postoperatively were evaluated.
  
  
  METHODS
  HemoSep concentrates blood by removing the fluid component from a pooled volume of blood salvaged at the end of the operation from the heart-lung machine. During a 6-month period, 102 patients were prospectively randomized into two groups. In group 1 (n = 52), salvaged blood in the venous reservoir after the cessation of cardiopulmonary bypass was reused by the HemoSep device and the processed blood was retransfused to the patients. In group 2 (n = 50), the control group, the operation proceeded using conventional method without using the hemoconcentrator.
  
  
  RESULTS
  The mean amount of processed blood was 775 ± 125 mL. The efficacy of the HemoSep device was confirmed by the percentage concentration of the hematocrit at 15 and 40 minutes. Serum albumin and factor VII levels were concentrated more than threefold at 40 minutes vs baseline measurements. Patients who received processed blood had significantly less need for an allogeneic transfusion.
  
  
  CONCLUSIONS
  The HemoSep device functions as designed and without technical failures, offering a complementary technique in blood management during cardiac operations.
authors.affiliation: Department of Cardiovascular Surgery, University of Kirikkale, Golbasi-Ankara, Turkey. sgunaydin@isnet.net.tr
authors.forename: Serdar
authors.initials: S
authors.lastname: Gunaydin
authors.forename: Terence
authors.initials: T
authors.lastname: Gourlay
mesh_terms: D000368:Aged; D016063:Blood Loss, Surgical / Q000517:prevention & control; D057668:Bloodless Medical and Surgical Procedures / Q000295:instrumentation* / Q000379:methods; D001026:Coronary Artery Bypass / Q000379:methods* / Q000401:mortality; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D004867:Equipment Design; D004869:Equipment Safety; D005260:Female; D005500:Follow-Up Studies; D006355:Heart-Lung Machine; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D012016:Reference Values; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome; D014462:Ultrafiltration / Q000295:instrumentation / Q000379:methods; D006113:United Kingdom