title: Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines.
abstract: The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators of systemic insulin sensitivity and metabolic homeostasis. However, the realization that skeletal muscle also secretes a variety of biologically and metabolically active polypeptide factors (collectively called myokines) has provided a new conceptual framework to understand the critical role skeletal muscle plays in coordinating whole-body energy balance. Here, we highlight recent progress made in the myokine field and discuss possible roles of myonectin, which we have recently identified as a potential postprandial signal derived from skeletal muscle to integrate metabolic processes in other tissues, such as adipose and liver; one of its roles is to promote fatty acid uptake into cells. Myonectin is also likely an important mediator in inter-tissue crosstalk.
authors.affiliation: Department of Physiology and Center for Metabolism and Obesity Research; The Johns Hopkins University School of Medicine; Baltimore, MD USA.
authors.forename: Marcus M
authors.initials: MM
authors.lastname: Seldin
authors.forename: G William
authors.initials: GW
authors.lastname: Wong
keywords: CTRP15; FABP; FATP; energy balance; fatty acids; lipid uptake; myokine; myonectin; skeletal muscle