title: [Interluekin-1: from regulation of cell proliferation to chronic inflammatory diseases].
abstract: Interleukin 1 (IL-1) was initially defined as a factor which is produced by macrophages and exhibits proliferative activity on thymocytes and fibroblasts, B cell activation and endogenous pyrogen activity. Now IL-1 is known to exhibit pleiotropic activities on various cell types and play important roles in the regulation of immune, nervous and endocrine systems, progression of tumor cells, hematopoietic cell proliferation/differentiation and especially in inflammatory diseases. In 1985 I found that IL-1 exhibits cytocidal activity against human melanoma cells. Since then I have been engaged in the research of various aspects of IL-1. This review summarizes current knowledge of IL-1, including our research and beneficial effect of IL-1 blocking on inflammatory diseases.
authors.affiliation: Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan. onozakikikuo@yahoo.co.jp
authors.forename: Kikuo
authors.initials: K
authors.lastname: Onozaki
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D049109:Cell Proliferation; D002908:Chronic Disease; D004703:Endocrine System / Q000276:immunology; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology*; D007375:Interleukin-1 / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D058990:Molecular Targeted Therapy; D015213:Neuroimmunomodulation / Q000276:immunology; D017472:Receptors, Interleukin-1; D060168:Thymocytes / Q000166:cytology
chemical_list: D007375:Interleukin-1; D017472:Receptors, Interleukin-1; C008270:leukocyte endogenous mediator