title: Discovery of non-LBD inhibitor for androgen receptor by structure-guide design.
abstract: In this study, we synthesized the BF-3 binding small molecules, a series of pyridazinone-based compounds, as a novel class of non-LBP antiandrogens for treating prostate cancer by inhibiting androgen receptor. The new class compound was discovered to inhibitor the viability of AR-dependent human prostate LNCap cells and AR activity combining with the computational method. It showed a good physicochemical and PK property.
authors.affiliation: Laboratory of Translational Therapeutics, Pharmacology Research Center, Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, P.O. Box 107, Yuseong-gu, Daejeon 305-600, Republic of Korea.
authors.forename: Byung Jun
authors.initials: BJ
authors.lastname: Ryu
authors.forename: Nakjeong
authors.initials: N
authors.lastname: Kim
authors.forename: Jun Tae
authors.initials: JT
authors.lastname: Kim
authors.forename: Tae-Sung
authors.initials: TS
authors.lastname: Koo
authors.forename: Sung-Eun
authors.initials: SE
authors.lastname: Yoo
authors.forename: Seo Hee
authors.initials: SH
authors.lastname: Jeong
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Nam Sook
authors.initials: NS
authors.lastname: Kang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011724:Pyridazines / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011944:Receptors, Androgen / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011724:Pyridazines; D011944:Receptors, Androgen