title: Mesoporous bioactive glass as a drug delivery system: fabrication, bactericidal properties and biocompatibility.
abstract: Implant-associated infection remains a difficult medical problem in orthopaedic surgery. Here, we report on the fabrication of gentamicin-loaded mesoporous bioactive glass (Gent-MBG) for use as a controlled antibiotic delivery system to achieve the sustained release of antibiotics in the local sites of bone defects. The high surface area and mesoporous structure of MBG enable higher drug loading efficiency (79-83 %) than non-mesoporous biological glass (NBG) (18-19 %). Gent-MBG exhibits sustained drug release for more than 6 days, and this controlled release of gentamicin significantly inhibits bacterial adhesion and prevents biofilm formation by S. aureus (ATCC25923) and S. epidermidis (ATCC35984). Biocompatibility tests with human bone marrow stromal cells (hBMSCs) indicate that MBG has better biocompatibility than NBG. Therefore, Gent-MBG can be used as a controlled drug delivery system to prevent and/or treat orthopedic peri-implant infections.
authors.affiliation: Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Yi-Zhuo
authors.initials: YZ
authors.lastname: Liu
authors.forename: Teng
authors.initials: T
authors.lastname: Long
authors.forename: Xi-Bin
authors.initials: XB
authors.lastname: Yu
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Tang
authors.forename: Ke-Rong
authors.initials: KR
authors.lastname: Dai
authors.forename: Bo
authors.initials: B
authors.lastname: Tian
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Guo
authors.forename: Zhen-An
authors.initials: ZA
authors.lastname: Zhu
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D002516:Ceramics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods; D004353:Drug Evaluation, Preclinical; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D008422:Materials Testing / Q000379:methods; D008826:Microbial Sensitivity Tests; D055616:Microtechnology / Q000379:methods; D016062:Porosity; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; C022107:Bioglass; D004337:Drug Carriers; D005839:Gentamicins