title: Transcriptional elongation checkpoint control in development and disease.
abstract: Transcriptional elongation control by RNA polymerase II and its associated factors has taken center stage as a process essential for the regulation of gene expression throughout development. In this review, we analyze recent findings on the identification of factors functioning in the regulation of the transcriptional elongation checkpoint control (TECC) stage of gene expression and how the factors' misregulation is associated with disease pathogenesis, including cancer.
authors.affiliation: Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
authors.forename: Edwin
authors.initials: E
authors.lastname: Smith
authors.forename: Ali
authors.initials: A
authors.lastname: Shilatifard
mesh_terms: D000818:Animals; D002843:Chromatin / Q000201:enzymology / Q000235:genetics; D004194:Disease; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics; D010766:Phosphorylation; D012319:RNA Polymerase II / Q000378:metabolism*; D013234:Stem Cells / Q000201:enzymology / Q000378:metabolism; D061805:Transcription Elongation, Genetic
chemical_list: D002843:Chromatin; D012319:RNA Polymerase II
keywords: RNA polymerase II; cancer; chromatin; elongation; transcription