title: Imbalance of circulating T-lymphocyte subpopulation in gastric cancer patients correlated with performance status.
abstract: BACKGROUND
  Performance status is an attempt to quantify cancer patients' general well-being. This measure is used to determine whether they can receive chemotherapy. This study was to determine the expression of T-lymphocyte subpopulation in patients with gastric cancer and the relationship between T-lymphocyte subpopulation expression and patient performance status.
  
  
  METHODS
  Flow cytometry was used to detect the T-lymphocyte subsets presented in peripheral blood in untreated patients with gastric cancer (n = 57) and healthy controls (n = 27). The gastric cancer patients were assessed with ECOG score and divided into two groups by score > 2 (n = 8) and score < or = 2 (n = 16). Spearman's rank correlation was used to determine the relationship between the proportion of T-lymphocytes and ECOG score. In addition, the clinical data of gastric cancer patients were Analyzed.
  
  
  RESULTS
  The percentage of CD8+ and CD4+ T-cells among lymphocytes was higher and lower, respectively, in advanced gastric cancer patients than that in early gastric cancer patients (p < 0.05). Furthermore, the percentage of CD8+ and CD4+ cells among lymphocytes was higher and lower in advanced gastric cancer patients with PS > 2 and PS < or = 2, respectively (p < 0.05). However, no significant difference of CD8+ and CD4+ lymphocytes was found among the advanced gastric cancer patients with PS < or = 2, early gastric cancer patients, and healthy controls.
  
  
  CONCLUSIONS
  Our results show that the determinants of the T-lymphocyte subpopulation in gastric cancer patients were of value in assessing performance status. We considered CD4+ and CD8+ T-lymphocytes to be a representative and stable parameter in quantifying cancer patients' general well-being, which could be used to determine whether they can receive chemotherapy and/or whether dose adjustment is necessary.
authors.affiliation: The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, 213003, China. xlyb99@yahoo.com.cn
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
mesh_terms: D000328:Adult; D000368:Aged; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000097:blood* / Q000503:physiopathology; D016176:T-Lymphocyte Subsets