title: [Changes in the characteristics of paradoxical sleep are an early feature of Parkison's disease].
abstract: Data on the sleep disorders in patients with Parkinson's disease are given. The basic point focuses on analysis of paradoxical sleep without muscle atonia. The author reports developed models of preclinical and clinical stages of Parkinson's disease in Wistar rats on the basis ofa moderate and deep attenuation in activity of ubiquitin-proteasome system, a key mechanism of aging and development of conformation disease. The hypothesis about changes in the characteristics of paradoxical sleep as a marker of parkinsonism stages is validated. It reflects the state of compensator and neuroprotective reserves of nigrostriatal dophaminergic system.
authors.forename: Iu F
authors.initials: IuF
authors.lastname: Pastukhov
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D059290:Dopaminergic Neurons / Q000378:metabolism* / Q000473:pathology; D004569:Electroencephalography; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D010300:Parkinson Disease / Q000378:metabolism / Q000503:physiopathology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012895:Sleep, REM; D025801:Ubiquitin / Q000378:metabolism*; D014851:Wakefulness
chemical_list: D018840:HSP70 Heat-Shock Proteins; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex; D004298:Dopamine