title: Cu(II) Schiff base complex as a highly efficient catalyst for the synthesis of polyhydroquinoline derivatives via Hantzsch condensation in water.
abstract: In the present study, Cu(II) Schiff-base complex is introduced as a highly efficient and green solid catalyst for the unsymmetrical Hantzsch condensation through a four-component coupling of various aldehydes, dimedone, ethyl acetoacetate and ammonium acetate to form polyhydroquinoline derivatives in good to excellent yields. This reaction was carried out in the presence of 1 mol% of catalysts in water at room temperature. The reusability of the catalysts was demonstrated by a five-run test. Remarkable features of this new procedure are cleaner reaction profiles, shorter reactiontimes, simple experimental and work-up procedures.
authors.affiliation: Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. m.vahdat@iauamol.ac.ir.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Vahdat
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011804:Quinolines / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014867:Water / Q000737:chemistry*
chemical_list: D011804:Quinolines; D012545:Schiff Bases; D014867:Water; D003300:Copper