title: Role of BAX for outcome prediction in gastrointestinal malignancies.
abstract: Our group and numerous others have shown in both preclinical and clinical studies that the proapoptotic mediator BAX may be deregulated through gene mutation or loss of protein expression, affecting resistance to chemotherapy and radiotherapy in several cancer types. However, BAX is also involved in cancer development and may related to prognosis, independently of treatment outcome. The clinical impact of BAX status in gastrointestinal malignancies remains controversial, although it is generally hypothesized that high expression may be a positive prognostic factor and predict increased efficacy of chemotherapy (with particular regard to platinum derivatives). The present review aims to provide updated information on BAX as potential prognostic and/or predictive biomarker in gastroesophageal and colorectal cancers, as well as in other less studied gastrointestinal malignancies.
authors.affiliation: Medical Oncology Unit 1, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, 20133 Milan, Italy. filippo.pietrantonio@istitutotumori.mi.it
authors.forename: Filippo
authors.initials: F
authors.lastname: Pietrantonio
authors.forename: Pamela
authors.initials: P
authors.lastname: Biondani
authors.forename: Elisa
authors.initials: E
authors.lastname: Ciurlia
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Fanetti
authors.forename: Anna
authors.initials: A
authors.lastname: Tessari
authors.forename: Gaia
authors.initials: G
authors.lastname: Bertarelli
authors.forename: Ilaria
authors.initials: I
authors.lastname: Bossi
authors.forename: Valeria
authors.initials: V
authors.lastname: Musella
authors.forename: Flavia
authors.initials: F
authors.lastname: Melotti
authors.forename: Maria
authors.initials: M
authors.lastname: Di Bartolomeo
authors.forename: Francesca
authors.initials: F
authors.lastname: Valvo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pellegrinelli
authors.forename: Massimo
authors.initials: M
authors.lastname: Milione
authors.forename: Federica
authors.initials: F
authors.lastname: Perrone
authors.forename: Filippo
authors.initials: F
authors.lastname: de Braud
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D005770:Gastrointestinal Neoplasms / Q000235:genetics / Q000473:pathology*; D006801:Humans; D011379:Prognosis; D016896:Treatment Outcome; D051028:bcl-2-Associated X Protein / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D051028:bcl-2-Associated X Protein