title: Phosphorylated c-Src is a novel predictor for recurrence in cervical squamous cell cancer patients.
abstract: OBJECTIVE
  The molecular mechanisms of the tumorigenesis and recurrence of cervical cancer are poorly understood. The objective of this study was to analyze the expression of phosphorylated c-Src (phospho-c-Src) and its clinical significance in human cervical cancer.
  
  
  METHODS
  The expression of phospho-c-Src was determined by immunohistochemistry in a total of 127 cervical specimens including 20 normal cervix tissues, 20 cases of carcinoma in situ of cervix (CIS), and 87 cases of cervical squamous cell carcinoma (CSCC).
  
  
  RESULTS
  The expression of phospho-Src in normal cervix, CIS, and CSCC increased gradually in ascending order (p=0.026). In addition, the expression of phospho-Src was correlated with overall (p=0.037) and recurrence (p=0.001) survival of cervical cancer. In multivariate Cox regression analysis, phospho-Src expression was an independent prognosis factor for recurrence-free survival (p=0.004).
  
  
  CONCLUSIONS
  Our present study suggests that Src signaling may play essential role in cervical cancer progression. Phospho-Src expression may be considered as a prognostic marker to predict recurrence in CSCC.
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, GD 510060, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Hou
authors.forename: Juan
authors.initials: J
authors.lastname: Xiao
authors.forename: Huiting
authors.initials: H
authors.lastname: Zhang
authors.forename: Haifeng
authors.initials: H
authors.lastname: Gu
authors.forename: Yanling
authors.initials: Y
authors.lastname: Feng
authors.forename: Jundong
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D002278:Carcinoma in Situ / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D016022:Case-Control Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D010766:Phosphorylation; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D019061:src-Family Kinases / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D019061:src-Family Kinases
keywords: Phospho-Src; cervical squamous cell carcinoma; prognosis; recurrence