title: Direct synthesis of 2,5-disubstituted oxazoles through an iodine-catalyzed decarboxylative domino reaction.
abstract: An efficient iodine-catalyzed synthesis of highly substituted oxazoles is presented. Starting from readily available aryl methyl ketones, β-keto esters, or styrenes, in combination with α-amino acids as amine-containing coupling partners, the corresponding 2-alkyl-5-aryl- substituted oxazoles were obtained in up to 80% yield via a decarboxylative domino reaction.
authors.affiliation: Institute of Organic Chemistry, Eberhard Karls University Tuebingen, Auf der Morgenstelle 18, D-72076 Tuebingen, Germany.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kloeckner
authors.forename: Boris J
authors.initials: BJ
authors.lastname: Nachtsheim
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004952:Esters / Q000737:chemistry; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis*; D013343:Styrenes / Q000737:chemistry
chemical_list: D000596:Amino Acids; D004952:Esters; D010080:Oxazoles; D013343:Styrenes; D007455:Iodine