title: The electrophoretical determination of serum protein fractions in lycopene treated experimental diabetic rats.
abstract: This study was planned to determine the effects of lycopene treatment on serum protein fractions in experimental diabetic rats. In order to induce diabetes in rats in the diabetes (D) and diabetes + lycopene (DL) groups, rats were given 45 mg/kg single-dose streptozotocin intraperitoneally. Lycopene (10 mg/kg/day dissolved in sunflower oil) was administered to the rats in the lycopene-only (L) and DL groups. Blood glucose levels and HbA1c% in DL group and diabetes group increased (p < 0.05) compared to control and L group. Total protein, albumin, α1, α2, and β globulin fractions of diabetic and DL groups were lower than control and L groups (p < 0.05). D group had lowest gamma (γ) globulin levels among other groups (p < 0.05). The γ globulin levels was slightly increased than diabetic groups (D and DL), but it was still lower than control and L groups (p < 0.05). The highest value of A/G ratio was observed in diabetic group. Similarly, the % level of A/G ratio of D group was higher than other groups. It was noted that the A/G ratio decreased and reached to control group levels after lycopene treatment.
authors.affiliation: Biochemistry Department, Veterinary Medicine School, Yuzuncu Yil University, 65080, Van, Turkey.
authors.forename: Veysel
authors.initials: V
authors.lastname: Yuksek
authors.forename: Semiha
authors.initials: S
authors.lastname: Dede
authors.forename: Ebubekir
authors.initials: E
authors.lastname: Ceylan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000737:chemistry / Q000378:metabolism*; D002338:Carotenoids / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004587:Electrophoresis, Agar Gel; D006442:Glycated Hemoglobin / Q000378:metabolism; D000077276:Lycopene; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000737:chemistry / Q000378:metabolism; D005719:gamma-Globulins / Q000737:chemistry / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D001798:Blood Proteins; D002338:Carotenoids; D006442:Glycated Hemoglobin; D000077276:Lycopene; D012709:Serum Albumin; D005719:gamma-Globulins