title: Consumption of mixed fruit-juice drink and vitamin C reduces postprandial stress induced by a high fat meal in healthy overweight subjects.
abstract: Postprandial stress induced by acute consumption of meals with a high fat content results in an increase of markers of cardiometabolic risk. Repeated acute dietary stress may induce a persistent low-grade inflammation, playing a role in the pathogenesis of functional gut diseases. This may cause an impairment of the complex immune response of the gastrointestinal mucosa, which results in a breakdown of oral tolerance. We investigated the effect of ingestion of a fruit-juice drink (FJD) composed by multiple fruit juice and extracts, green tea extracts and vitamin C on postprandial stress induced by a High Fat Meal (HFM) in healthy overweight subjects. Following a double blind, placebo controlled, cross-over design, 15 healthy overweight subjects were randomized to a HFM providing 1334 Kcal (55% fat, 30% carbohydrates and 15% proteins) in combination with 500 mL of a placebo drink (HFM-P) or a fruit-juice drink (HFM-FJD). Ingestion of HFM-P led to an increase in circulating levels of cholesterol, triglycerides, glucose, insulin, TNF-α and IL-6. Ingestion of HFM-FJD significantly reduced plasma levels of cholesterol and triglycerides, decreasing inflammatory response mediated by TNF-α and IL-6. Ingestion of a fruit-juice drink reduce markers of postprandial stress induced by a HFM.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Peluso
authors.forename: Debora V
authors.initials: DV
authors.lastname: Villano
authors.forename: Susan A
authors.initials: SA
authors.lastname: Roberts
authors.forename: Eleonora
authors.initials: E
authors.lastname: Cesqui
authors.forename: Anna
authors.initials: A
authors.lastname: Raguzzini
authors.forename: Gina
authors.initials: G
authors.lastname: Borges
authors.forename: Alan
authors.initials: A
authors.lastname: Crozier
authors.forename: Giovina
authors.initials: G
authors.lastname: Catasta
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Toti
authors.affiliation: CRA ex-INRAN, Via Ardeatina, 546, 00178 Rome, Italy. serafini_mauro@yahoo.it.
authors.forename: Mauro
authors.initials: M
authors.lastname: Serafini
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D001628:Beverages; D001786:Blood Glucose / Q000378:metabolism; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D005638:Fruit; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000378:metabolism*; D019518:Postprandial Period; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D015850:Interleukin-6; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha; D001205:Ascorbic Acid