title: Against all odds: anti-IgE for intrinsic asthma?
abstract: For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment.
authors.affiliation: Department of Pneumology and Critical Care Medicine, University of Rostock, , Rostock, Germany.
authors.forename: Marek
authors.initials: M
authors.lastname: Lommatzsch
authors.forename: Stephanie
authors.initials: S
authors.lastname: Korn
authors.forename: Roland
authors.initials: R
authors.lastname: Buhl
authors.forename: Johann Christian
authors.initials: JC
authors.lastname: Virchow
mesh_terms: D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology*; D018450:Disease Progression; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D007437:Intrinsic Factor; D000069444:Omalizumab
chemical_list: D018927:Anti-Asthmatic Agents; D000888:Antibodies, Anti-Idiotypic; D061067:Antibodies, Monoclonal, Humanized; D000069444:Omalizumab; D007437:Intrinsic Factor
keywords: Asthma; Asthma Mechanisms; Asthma Pharmacology