title: The impact of prenatal serotonin reuptake inhibitor (SRI) antidepressant exposure and maternal mood on mother-infant interactions at 3 months of age.
abstract: Exposure to maternal depression increases risks for altered mother-infant interactions. Serotonin reuptake inhibitor (SRI) antidepressants are increasingly prescribed to manage antenatal maternal illness. The impact of SRIs on early mother-infant interactions was unknown. Three-month-old infants of 32 depressed mothers treated with SRI medications during pregnancy and 43 non-medicated mothers were studied. Using an established face-to-face mother-infant interaction paradigm, dyad interactions were studied with and without a toy. Videotaped sessions yielded 4 measures: maternal sensitivity, dyadic organization, infant readiness to interact, and maternal interruptive behaviors. Even with prenatal SRI treatment, depressed mothers interrupted their infants more during toy play. In the absence of prenatal SRI treatment, maternal postnatal depression adversely influenced infant behavior. Higher levels of maternal depression symptoms at 3 months predicted poorer infant readiness to interact during the toy session. Conversely, in the SRI-exposed group, higher prenatal depression scores predicted greater infant readiness to interact at 3 months. Increased infant readiness with SRI exposure suggests a "fetal programming effect" whereby prenatal maternal mood disturbances shaped a future response to a postnatal depressed maternal environment.
authors.affiliation: Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Whitney M
authors.initials: WM
authors.lastname: Weikum
authors.forename: Linda C
authors.initials: LC
authors.lastname: Mayes
authors.forename: Ruth E
authors.initials: RE
authors.lastname: Grunau
authors.forename: Ursula
authors.initials: U
authors.lastname: Brain
authors.forename: Tim F
authors.initials: TF
authors.lastname: Oberlander
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects*; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008425:Maternal Behavior / Q000187:drug effects / Q000523:psychology; D009034:Mother-Child Relations; D009035:Mothers / Q000523:psychology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Infant development; Maternal depression; Mother–infant interaction; Prenatal exposure; Serotonin reuptake inhibitor