title: Underreporting of Dengue-4 in Brazil due to low sensitivity of the NS1 Ag test in routine control programs.
abstract: We have identified fifty-eight samples that were positive for Dengue-4 among 119 samples with negative diagnoses for dengue via the Platelia™ dengue NS1 Ag in Aracaju, State of Sergipe, Brazil. We determined that the low sensitivity of the NS1 Ag test could be related to secondary dengue infections in the studied population. Therefore, we concluded that the sensitivity and specificity of the Platelia™ dengue NS1 Ag test as a screening method for monitoring circulating dengue serotypes must be reevaluated. In addition, regional endo-epidemic profiles should also be considered due to the prevalence of secondary responses.
authors.affiliation: Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil.
authors.forename: Vanessa Ramos Faria
authors.initials: VR
authors.lastname: Sea
authors.forename: Ana Cecília Ribeiro
authors.initials: AC
authors.lastname: Cruz
authors.forename: Ricardo Q
authors.initials: RQ
authors.lastname: Gurgel
authors.forename: Bruno Tardelli Diniz
authors.initials: BT
authors.lastname: Nunes
authors.forename: Eliana Vieira Pinto
authors.initials: EV
authors.lastname: Silva
authors.forename: Silvio S
authors.initials: SS
authors.lastname: Dolabella
authors.forename: Roseli La Corte
authors.initials: RL
authors.lastname: dos Santos
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral / Q000276:immunology; D001938:Brazil / Q000453:epidemiology; D003715:Dengue / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D003716:Dengue Virus / Q000276:immunology*; D003951:Diagnostic Errors; D058872:Epidemics; D006801:Humans; D015994:Incidence; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D017361:Viral Nonstructural Proteins / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D011933:Reagent Kits, Diagnostic; D017361:Viral Nonstructural Proteins