title: Clofazimine-induced enteropathy in a patient of leprosy.
abstract: Clofazimine-induced crystal-storing histiocytosis is a rare but well-recognized condition reported in literature. In addition to common reddish discoloration of the skin, clofazimine produces gastrointestinal disorder, sometimes severe abdominal pain. Also, the pathologic and radiologic findings can produce diagnostic difficulties if the pathological changes caused by it are not known. The authors report a case in a patient of leprosy to emphasize the importance of history, radiologic, and pathologic findings in small intestine. Clofazimine crystals are red in the frozen section and display bright-red birefringence. With the knowledge of this rare condition caused by clofazimine, appropriate management to avoid an unnecessary laparotomy is possible.
authors.affiliation: Department of Pharmacology, Guru Gobind Singh Medical College, Faridkot, Punjab, India.
authors.forename: Harminder
authors.initials: H
authors.lastname: Singh
authors.forename: Khemlal
authors.initials: K
authors.lastname: Azad
authors.forename: Kamalpreet
authors.initials: K
authors.lastname: Kaur
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced*; D002991:Clofazimine / Q000009:adverse effects*; D005767:Gastrointestinal Diseases / Q000139:chemically induced*; D015614:Histiocytosis / Q000139:chemically induced*; D006801:Humans; D007917:Leprostatic Agents / Q000009:adverse effects*; D007918:Leprosy / Q000188:drug therapy*; D008297:Male; D055815:Young Adult
chemical_list: D007917:Leprostatic Agents; D002991:Clofazimine
keywords: Clofazimine; leprosy; multi drug therapy