title: Cerebrospinal fluid HIV-1 compartmentalization in a patient with AIDS and acute varicella-zoster virus meningomyeloradiculitis.
abstract: We report a case of AIDS presenting as varicella-zoster virus (VZV) meningomyeloradiculitis associated with human immunodeficiency virus (HIV) quasispecies compartmentalization within the cerebrospinal fluid (CSF), and a CSF viral load that was 1 log higher than in peripheral blood. Prolonged antiviral therapy for both VZV and HIV type 1 was associated with partial resolution.
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1684, USA. emilia.falcone@nih.gov
authors.forename: E Liana
authors.initials: EL
authors.lastname: Falcone
authors.forename: Ademiposi A
authors.initials: AA
authors.lastname: Adegbulugbe
authors.forename: Virginia
authors.initials: V
authors.lastname: Sheikh
authors.forename: Hiromi
authors.initials: H
authors.lastname: Imamichi
authors.forename: Robin L
authors.initials: RL
authors.lastname: Dewar
authors.forename: Dima A
authors.initials: DA
authors.lastname: Hammoud
authors.forename: Irini
authors.initials: I
authors.lastname: Sereti
authors.forename: H Clifford
authors.initials: HC
authors.lastname: Lane
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D000998:Antiviral Agents / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006562:Herpes Zoster / Q000150:complications* / Q000821:virology; D006801:Humans; D008297:Male; D008587:Meningitis, Viral / Q000473:pathology*; D008875:Middle Aged; D009187:Myelitis / Q000473:pathology*; D011843:Radiculopathy / Q000473:pathology*
chemical_list: D000998:Antiviral Agents
keywords: central nervous system compartmentalization; human immunodeficiency virus; meningomyeloradiculitis; varicella-zoster virus; viral quasispecies