title: Comparison of 18 FDG PET-CT and bone scintigraphy for detection of bone metastases in breast cancer patients. A meta-analysis.
abstract: BACKGROUND
  We performed a meta-analysis to compare the accuracy of (18)FDG PET-CT and bone scintigraphy for the detection of bone metastases in breast cancer patients.
  
  
  METHODS
  Studies about (18)FDG PET-CT and bone scintigraphy for the detection of bone metastases in breast cancer patients were systematically searched in the MEDLINE and EMBASE databases. We calculated sensitivities, specificities, diagnostic odds ratios, and likelihood ratios, and constructed summary receiver operating characteristic curves using bivariate regression models for (18)FDG PET-CT and bone scintigraphy, respectively.
  
  
  RESULTS
  Across 7 studies (668 patients), sensitivity and specificity of PET-CT 0.93 (95% confidence interval [CI] = 0.82-0.98) and 0.99 (95% CI = 0.95-1.00), and of bone scintigraphy were 0.81 (95% CI = 0.58-0.93) and 0.96 (95%CI = 0.76-1.00), respectively. Area under curves for PET-CT and bone scintigraphy was 0.98 (95% CI = 0.98-1.00) and 0.94 (95% CI = 0.92-0.96), respectively.
  
  
  CONCLUSIONS
  Compared with bone scintigraphy, (18)FDG PET-CT may higher sensitivity and accuracy for detection of bone metastases in breast cancer patients.
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, Guanghzou, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Rong
authors.forename: Siyang
authors.initials: S
authors.lastname: Wang
authors.forename: Qiue
authors.initials: Q
authors.lastname: Ding
authors.forename: Miao
authors.initials: M
authors.lastname: Yun
authors.forename: Zhousan
authors.initials: Z
authors.lastname: Zheng
authors.forename: Sheng
authors.initials: S
authors.lastname: Ye
mesh_terms: D005260:Female; D006801:Humans; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology / Q000556:secondary; D019788:Fluorodeoxyglucose F18; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18; D019275:Radiopharmaceuticals