title: Effects of vancomycin, cefazolin and test conditions on the wear behavior of bone cement.
abstract: Antibiotic cement has been recommended in the treatment of prosthetic infections. The purpose of this study was to investigate the mechanical behavioral changes in cement loaded with two antibiotics, vancomycin and cefazolin, in dry and liquid medium. Six groups and four study conditions were established according to the doses of antibiotic used and the ageing (immersion in phosphate buffered saline) of the samples. Properties evaluated were friction coefficient and wear. Samples in dry medium showed higher wears than in liquid. Antibiotic selection did not influence wear properties tested in dry conditions, however, in liquid medium, there were higher frictional coefficients and wear for cefazolin loaded cement after one week and for vancomycin and cefazolin after one month. The results suggest that antibiotic cements behave differently in liquid and that the molecular characteristics of antibiotics are essential for determining this influence.
authors.affiliation: Department of Traumatology and Orthopaedic Surgery, General University Hospital Gregorio Marañón, Madrid, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Sanz-Ruiz
authors.forename: Eva
authors.initials: E
authors.lastname: Paz
authors.forename: Juana
authors.initials: J
authors.lastname: Abenojar
authors.forename: Juan
authors.initials: J
authors.lastname: Carlos del Real
authors.forename: Javier
authors.initials: J
authors.lastname: Vaquero
authors.forename: Francisco
authors.initials: F
authors.lastname: Forriol
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry*; D002437:Cefazolin / Q000737:chemistry*; D017276:Friction; D008422:Materials Testing; D055595:Mechanical Phenomena / Q000187:drug effects*; D008855:Microscopy, Electron, Scanning; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry; D014640:Vancomycin / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D012965:Sodium Chloride; D014640:Vancomycin; D019904:Polymethyl Methacrylate; D002437:Cefazolin
keywords: antibiotic-loaded cement; arthroplasty infection; bone cement; friction; polymethylmethacrylate (PMMA)