title: [Nonantibiotic properties of macrolides and their role in modulation of the inflammatory reaction].
abstract: Macrolides is one of the most interesting and promising classes of antibiotics, which occupy one of the first places in the world in the frequency of clinical use. In recent years, new facts have reported about specific features of the mechanism of action and pharmacodynamics of macrolides, in particular, with respect to their anti-inflammatory effect. Unfortunately, many therapists and pharmacists are not familiar with recent advanced in the clinical and pharmacological evidence concerning extra-antibiotic properties characteristic of some macrolides. Macrolides increase defensive mechanisms of the body against infection at the first stage of their action and suppress inflammation at the next stages, which leads to faster resolution of a disease. The immunomodulating properties of macrolides are also discussed and require further investigation. Good prospects are related with combined therapy, in which antibiotics are used jointly with drugs potentiating their extra-antibiotic effect and overwhelming negative effects on the body. This approach will significantly improve the efficiency of therapy, reduce the risk of side effects, and reduce the cost of treatment.
authors.forename: I A
authors.initials: IA
authors.lastname: Zupanets
authors.forename: E M
authors.initials: EM
authors.lastname: Tkachenko
authors.forename: T S
authors.initials: TS
authors.lastname: Sakharova
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D058492:Drug Repositioning; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use*; D007249:Inflammation; D018942:Macrolides / Q000494:pharmacology / Q000627:therapeutic use*; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007155:Immunologic Factors; D018942:Macrolides