title: Evaluation of ozonated olive oil with or without adjunctive application of calcium sodium phosphosilicate on post-surgical root dentin hypersensitivity: a randomized, double-blinded, controlled, clinical trial.
abstract: OBJECTIVE
  This study was conducted to evaluate the efficacy of ozonated olive oil with or without adjunctive application of mineral wash containing calcium sodium phosphosilicate on the reversal of post-surgical root dentin hypersensitivity.
  
  
  METHODS
  A double-blinded, randomized controlled clinical trial was conducted on 51 participants with root dentin hypersensitivity (RDH). Participants were randomLy assigned to 4 groups: Group A, ozonated olive oil (OZO): Group B, ozonated olive oil and mineral wash: Group C, placebo olive oil (PPO) and mineral wash: Group D, placebo olive oil only. Active treatment was carried out in-clinic and followed by at-home care with a remineralising paste. The response to various pain stimuli was periodically assessed with a visual analogue scale. Additionally, scanning electron microscopic study assessed the dentinal tubule occlusion and change in tubular surface area after treatment.
  
  
  RESULTS
  The group B participants showed a significant decrease in tooth level and global sensitivity over the period (P<0.001). Moreover, the intergroup comparison also revealed a significant result (P<0.001). Similarly, participants of group C also showed a significant reduction in sensitivity over the period (P<0.001). Whereas, no significant (P>0.05) difference was detected between group A and group D for tooth level and global sensitivity analysis. The SEM study result showed a significantly (P<0.001) enhanced tubule occlusion and decreased tubular surface area in group B specimens compared to other group specimens.
  
  
  CONCLUSIONS
  OZO, as a mono-therapy is not efficient in reducing post-surgical RDH. However, the adjunctive application of mineral wash containing calcium sodium phosphosilicate has positive impact on the reversal of post-surgical root dentin hypersensitivity.
authors.affiliation: Kalindi Oro Care and Research Centre, Rashmi Nagar, Lanka, Varanasi, Uttar Pradesh, India. punitvai@gmail.com
authors.forename: P V
authors.initials: PV
authors.lastname: Patel
authors.forename: A
authors.initials: A
authors.lastname: Patel
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.forename: J C
authors.initials: JC
authors.lastname: Holmes
mesh_terms: D000328:Adult; D000368:Aged; D003080:Cold Temperature; D003804:Dentin / Q000187:drug effects / Q000648:ultrastructure; D003807:Dentin Sensitivity / Q000188:drug therapy* / Q000209:etiology; D004311:Double-Blind Method; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D009067:Mouthwashes; D000069463:Olive Oil; D019647:Oral Surgical Procedures; D010126:Ozone; D010147:Pain Measurement; D010510:Periodontal Diseases / Q000601:surgery; D010710:Phosphates / Q000627:therapeutic use*; D010938:Plant Oils / Q000737:chemistry / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology; D011312:Pressure; D017640:Silicates / Q000627:therapeutic use*; D014099:Toothbrushing
chemical_list: D009067:Mouthwashes; D000069463:Olive Oil; D010710:Phosphates; D010938:Plant Oils; D017640:Silicates; D010126:Ozone