title: Nanocrystalline β-Ti alloy with high hardness, low Young's modulus and excellent in vitro biocompatibility for biomedical applications.
abstract: High strength, low Young's modulus and good biocompatibility are desirable but difficult to simultaneously achieve in metallic implant materials for load bearing applications, and these impose significant challenges in material design. Here we report that a nano-grained β-Ti alloy prepared by high-pressure torsion exhibits remarkable mechanical and biological properties. The hardness and modulus of the nano-grained Ti alloy were respectively 23% higher and 34% lower than those of its coarse-grained counterpart. Fibroblast cell attachment and proliferation were enhanced, demonstrating good in vitro biocompatibility of the nano-grained Ti alloy, consistent with demonstrated increased nano-roughness on the nano-grained Ti alloy. Results suggest that the nano-grained β-Ti alloy may have significant application as an implant material in dental and orthopedic applications.
authors.affiliation: Australian Centre for Microscopy and Microanalysis, The University of Sydney, Sydney, NSW 2006, Australia.
authors.forename: Kelvin Y
authors.initials: KY
authors.lastname: Xie
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Wang
authors.forename: Yonghao
authors.initials: Y
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Chang
authors.forename: Guocheng
authors.initials: G
authors.lastname: Wang
authors.forename: Zibin
authors.initials: Z
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Cao
authors.forename: Xiaozhou
authors.initials: X
authors.lastname: Liao
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: Lavernia
authors.forename: Ruslan Z
authors.initials: RZ
authors.lastname: Valiev
authors.forename: Babak
authors.initials: B
authors.lastname: Sarrafpour
authors.forename: Hans
authors.initials: H
authors.lastname: Zoellner
authors.forename: Simon P
authors.initials: SP
authors.lastname: Ringer
mesh_terms: D000497:Alloys / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D055119:Elastic Modulus; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D011312:Pressure; D013718:Tensile Strength; D014025:Titanium / Q000737:chemistry*
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D014025:Titanium