title: JAV1 controls jasmonate-regulated plant defense.
abstract: Plants evolve effective mechanisms to protect themselves from environmental stresses and employ jasmonates as vital defense signals to defend against insect attack and pathogen infection. Jasmonates are also recognized as an essential growth regulator by which diverse developmental processes are mediated. Despite substantial research, there are no key signaling components reported yet to control jasmonate-regulated plant defense independent of developmental responses. We identify JAV1, a key gene in the jasmonate pathway, which functions as a negative regulator to control plant defense but does not play a detectable role in plant development. Our results suggest that when encountering insect attack and pathogen infection, plants accumulate jasmonates that trigger JAV1 degradation via the 26S proteasome to activate defensive gene expression and elevate resistances against both insects and pathogens. These findings have provided insight into the molecular mechanism by which plants integrate jasmonate signals to protect themselves from insect attack and pathogen infection.
authors.affiliation: Tsinghua-Peking Center for Life Sciences, MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China.
authors.forename: Po
authors.initials: P
authors.lastname: Hu
authors.forename: Wu
authors.initials: W
authors.lastname: Zhou
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Cheng
authors.forename: Meng
authors.initials: M
authors.lastname: Fan
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Daoxin
authors.initials: D
authors.lastname: Xie
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017360:Arabidopsis / Q000235:genetics* / Q000378:metabolism / Q000469:parasitology; D029681:Arabidopsis Proteins / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D015153:Blotting, Western; D003517:Cyclopentanes / Q000494:pharmacology*; D060467:Disease Resistance / Q000187:drug effects / Q000235:genetics; D020869:Gene Expression Profiling; D018506:Gene Expression Regulation, Plant / Q000187:drug effects; D006790:Host-Parasite Interactions / Q000187:drug effects; D007313:Insecta / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D009154:Mutation; D020411:Oligonucleotide Array Sequence Analysis; D054883:Oxylipins / Q000494:pharmacology*; D010802:Phylogeny; D010935:Plant Diseases / Q000235:genetics* / Q000469:parasitology; D010937:Plant Growth Regulators / Q000494:pharmacology; D030821:Plants, Genetically Modified; D034622:RNA Interference; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid
chemical_list: D029681:Arabidopsis Proteins; D003517:Cyclopentanes; D047908:Intracellular Signaling Peptides and Proteins; C583033:JAV1 protein, Arabidopsis; D054883:Oxylipins; D010937:Plant Growth Regulators; C011006:jasmonic acid