title: Differential impact of β and γ residue preorganization on α/β/γ-peptide helix stability in water.
abstract: Cyclic constraints have proven to be very effective for preorganizing β-amino acid residues and thereby stabilizing β- and α/β-peptide helices, but little is known about possible preorganization effects among γ residues. Here we assess and compare the impact of cyclic preorganization of β and γ residues in the context of a specific α/β/γ-peptide helix. The results show that β residue preorganization is critical for helix stability but that γ residue preorganization is less important.
authors.affiliation: Department of Chemistry and ‡Department of Bacteriology, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Shin
authors.forename: David E
authors.initials: DE
authors.lastname: Mortenson
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Satyshur
authors.forename: Katrina T
authors.initials: KT
authors.lastname: Forest
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Gellman
mesh_terms: D018360:Crystallography, X-Ray; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D014867:Water / Q000737:chemistry*
chemical_list: D010455:Peptides; D014867:Water