title: New eudesmane sesquiterpenes from Alpinia oxyphylla and determination of their inhibitory effects on microglia.
abstract: The fruits of Alpinia oxyphylla are used as healthcare products for the protection on neurons and prevention of dementia. Two new noreudesmane sesquiterpenoids, (5R,7S,10S)-5-hydroxy-13-noreudesma-3-en-2,11-dione (1) and (10R)-13-noreudesma-4,6-dien-3,11-dione (2), and a new eudesmane sesquiterpenoid, (5S,8R,10R)-2-oxoeudesma-3,7(11)-dien-12,8-olide (3), as well as 12 known sesquiterpenoids, were isolated from the fruits of A. oxyphylla. The structures of the new compounds (1-3) were elucidated on the basis of spectroscopic data and circular dichroism experiments. All isolates were evaluated their neuroprotective potential by inhibitory assay on nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced mouse microglia BV-2 cells.
authors.affiliation: Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, PR China.
authors.forename: Bei
authors.initials: B
authors.lastname: Jiang
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Wang
authors.forename: Man-Ping
authors.initials: MP
authors.lastname: Li
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
authors.forename: Feng
authors.initials: F
authors.lastname: Huang
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Ping-Hua
authors.initials: PH
authors.lastname: Sun
authors.forename: Ming-Fang
authors.initials: MF
authors.lastname: He
authors.forename: Zheng-Jin
authors.initials: ZJ
authors.lastname: Jiang
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D032429:Alpinia / Q000737:chemistry*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D017628:Microglia / Q000187:drug effects* / Q000378:metabolism; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D008070:Lipopolysaccharides; D045787:Sesquiterpenes, Eudesmane; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide