title: The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors (rhVEGFs) on vertical bone regeneration in the marginal portion of the peri-implant.
  
  
  METHODS
  Supra-alveolar defects were created in 3 male beagle dogs. Each animal received 8 implants that were either coated with a single growth factor (rhBMP-2) or combined growth factors (rhBMP-2 + rhVEGF), or an anodized implant (the control group). The amount of the vertical bone regeneration, the bone-implant contact, and the intrathread bone density were investigated using histomorphometric analysis at 8 weeks.
  
  
  RESULTS
  The bone morphogenetic protein (BMP) group and the BMP-VEGF group showed vertical alveolar bone regeneration and enhanced bone-implant contact in the microthread compared with the control group (P < .05).
  
  
  CONCLUSIONS
  Anodized implants coated with rhBMP-2 and rhBMP - 2 + rhVEGF can induce vertical alveolar bone regeneration, but the combined effect of rhBMP-2 and rhVEGF was not verified.
authors.affiliation: Graduate Student, Advanced Prosthodontics, Postgraduate School of Clinical Dentistry, Institute for Clinical Dental Research, Korea University, Seoul, Korea.
authors.forename: Jong-Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Seong-Su
authors.initials: SS
authors.lastname: Kang
authors.forename: Kyung-Hee
authors.initials: KH
authors.lastname: Choi
authors.forename: June-Sung
authors.initials: JS
authors.lastname: Shim
authors.forename: Chang-Mo
authors.initials: CM
authors.lastname: Jeong
authors.forename: Sang-Wan
authors.initials: SW
authors.lastname: Shin
authors.forename: Jung-Bo
authors.initials: JB
authors.lastname: Huh
mesh_terms: D000539:Alveolar Process / Q000503:physiopathology / Q000601:surgery*; D000704:Analysis of Variance; D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D004285:Dogs; D008297:Male; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology*
chemical_list: D055396:Bone Morphogenetic Protein 2; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D042461:Vascular Endothelial Growth Factor A