title: Statin use and risk of cerebral aneurysm rupture: a hospital-based case-control study in Japan.
abstract: BACKGROUND
  Recent reports have showed that some statins have protective effects in experimental cerebral aneurysm models. We conducted a case-control study to investigate an association between statin use and the rupture risk of cerebral aneurysm in Japanese population.
  
  
  METHODS
  This was a multihospital case-control study; cases and controls were collected from 15 hospitals in Japan. Cases consisted of patients with aneurysmal subarachnoid hemorrhage hospitalized from April 2009 to March 2011. Controls were selected from patients who had newly diagnosed unruptured saccular aneurysms from April 2006 to March 2011. The primary exposure of interest was statin use. Multivariable logistic regression was used to assess the relationship between stain use and the rupture risk of cerebral aneurysm.
  
  
  RESULTS
  A total of 117 cases and 304 controls were included in the analyses. Statin was used in 9.4% of cases and 26.0% of controls. Controls had a significantly higher rate of use of statin. The use of any statin was associated with cerebral aneurysm rupture after adjustment of potential confounders (adjusted odds ratio: .30, 95% confidence interval: .14-.66). The association was similar in each stratum of total cholesterol level.
  
  
  CONCLUSIONS
  This observation from a hospital-based case-control study in Japan suggested that there is inverse relationship between use of statins and cerebral aneurysm rupture. Future clinical studies are needed.
authors.affiliation: Department of Neurosurgery, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, Japan. Electronic address: yayoi26@belle.shiga-med.ac.jp.
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Yoshimura
authors.affiliation: Department of Medical Statistics, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Murakami
authors.affiliation: Department of Neurosurgery, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Saitoh
authors.affiliation: Department of Neurosurgery, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Yokoi
authors.affiliation: Department of Pharmacology, Kyoto University Graduate School of Medicine, Knoe-cho Yoshida Sakyo-ku Kyoto, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Aoki
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, Japan; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Miura
authors.affiliation: Department of Health Science, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, Japan; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, Japan.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ueshima
authors.affiliation: Department of Neurosurgery, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nozaki
mesh_terms: D000368:Aged; D017542:Aneurysm, Ruptured / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D016009:Chi-Square Distribution; D005260:Female; D006761:Hospitals; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D002532:Intracranial Aneurysm / Q000150:complications* / Q000175:diagnosis; D007564:Japan; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Statin; case-control study; cerebral aneurysm; subarachnoid hemorrhage