title: Roles of levo-tetrahydropalmatine in modulating methamphetamine reward behavior.
abstract: Levo-tetrahydropalmatine (l-THP), as an alkaloid purified from the traditional Chinese herbal medicine Corydalis and Stephania, has been widely used to produce many traditional Chinese herbal preparations. The effect of l-THP on methamphetamine-induced reward learning still remains unclear although it has been proved to be effective on treating allodynia and drug addiction. This experiment has been designed to examine the effect of l-THP on the acquisition, expression, extinction, and reinstatement of methamphetamine-induced conditioned place preference (CPP) in mice. The results show that methamphetamine (METH) could induce CPP in mice at doses of 0.5mg/kg, 1.0mg/kg and 2.0mg/kg respectively, but l-THP alone could not do so. Meanwhile, l-THP could not induce conditioned place aversion at doses of 1.25mg/kg to 20.0mg/kg in mice, but it could attenuate the acquisition and expression of METH-induced CPP and facilitate the extinction of METH-induced CPP in mice. Besides, l-THP could inhibit the reinstatement of METH-induced CPP at the dose of 10.0mg/kg whether it was given in the extinction training phase or 30min before the reinstatement. These results suggest that l-THP can globally suppress the rewarding properties of METH on all phases of the CPP task and it may have potential effects on the treatment of METH abuse.
authors.affiliation: Department of Forensic Medicine, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, PR China.
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Su
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.forename: Yan-Jiong
authors.initials: YJ
authors.lastname: Chen
authors.forename: Na
authors.initials: N
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.forename: Yong-Hui
authors.initials: YH
authors.lastname: Dang
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.forename: Teng
authors.initials: T
authors.lastname: Chen
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001600:Berberine Alkaloids / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D031311:Corydalis / Q000737:chemistry; D003627:Data Interpretation, Statistical; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005108:Extinction, Psychological / Q000187:drug effects; D007858:Learning / Q000187:drug effects; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D012201:Reward; D031607:Stephania / Q000737:chemistry
chemical_list: D001600:Berberine Alkaloids; D000697:Central Nervous System Stimulants; D018492:Dopamine Antagonists; C014215:tetrahydropalmatine; D008694:Methamphetamine
keywords: Acquisition; CPP; Conditioned place preference; DA; Ext; Extinction; METH; Methamphetamine; Rein; Reinstatement; conditioned place preference; dopamine; extinction; i.p; intraperitoneal; l-THP; l-Tetrahydropalmatine; levo-tetrahydropalmatine; methamphetamine; reinstatement