title: [Influence of chosen metals on the citric acid cycle].
abstract: Industrial activity growth influenced not only technological progress, but also had negative effects on human natural environment. It results among others in increased human exposition to heavy metals. In case of detoxication mechanisms disturbance in organism, heavy metals cumulate in tissues causing mutations and disrupting metabolism, including Krebs cycle. Recent studies have revealed that iron, zinc and manganese have especially strong influence on Krebs cycle. These elements act as cofactors or inhibitors regulating activity of particular enzymes of this cycle, which has a reflection in cellular energy production disturbances.
authors.affiliation: Departament of Histology and Embriology, Medical University of Silesia, Katowice, Poland. ewarojczyk@gmail.com
authors.forename: Ewa
authors.initials: E
authors.lastname: Rojczyk-Gołebiewska
authors.forename: Marek
authors.initials: M
authors.lastname: Kucharzewski
mesh_terms: D002952:Citric Acid Cycle / Q000187:drug effects*; D004734:Energy Metabolism / Q000187:drug effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects*; D006801:Humans; D007501:Iron / Q000633:toxicity; D008345:Manganese / Q000633:toxicity; D019216:Metals, Heavy / Q000633:toxicity*; D015032:Zinc / Q000633:toxicity
chemical_list: D004785:Environmental Pollutants; D019216:Metals, Heavy; D008345:Manganese; D007501:Iron; D015032:Zinc