title: Comparison of a chlorambucil-prednisolone combination with an azathioprine-prednisolone combination for treatment of chronic enteropathy with concurrent protein-losing enteropathy in dogs: 27 cases (2007-2010).
abstract: OBJECTIVE
  To compare treatment protocols for chronic enteropathy and concurrent protein-losing enteropathy that used prednisolone in conjunction with either azathioprine or chlorambucil in dogs.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  27 dogs.
  
  
  METHODS
  All dogs had hypoalbuminemia (serum albumin concentration, < 18.0 g/L) and chronic enteropathy as diagnosed via complete gastrointestinal tract investigations including intestinal biopsy. Dogs received either an azathioprine-prednisolone combination (group A; n = 13) or a chlorambucil-prednisolone combination (group C; 14). Response to treatment was assessed by evaluation of body weight gain, serum albumin concentration, and duration of primary treatment.
  
  
  RESULTS
  No significant pretreatment differences were detected between groups for any baseline variable (signalment and weight), clinicopathologic variable (albumin, cobalamin, and folate concentrations), or histopathologic findings. After treatment, serum albumin concentration and weight gain were significantly greater in group C. Median survival time for group A dogs was 30 days (95% confidence interval, 15 to 45 days) and was not reached for group C dogs. Duration of primary treatment was positively associated with the histopathologic presence of mild lacteal dilatation and use of a chlorambucil-prednisolone combination.
  
  
  CONCLUSIONS
  Results suggested that a chlorambucil-prednisolone protocol is more efficacious for treatment of chronic enteropathy and concurrent protein-losing enteropathy, compared with an azathioprine-prednisolone combination. Given these findings, a prospective randomized clinical trial is warranted.
authors.affiliation: School of Veterinary Science, University of Liverpool, Neston CH64 7TE, England. jdandrieux@gmail.com
authors.forename: Julien R S
authors.initials: JR
authors.lastname: Dandrieux
authors.forename: Peter-John M
authors.initials: PJ
authors.lastname: Noble
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Scase
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Cripps
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: German
mesh_terms: D000818:Animals; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use*; D002699:Chlorambucil / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004359:Drug Therapy, Combination; D007410:Intestinal Diseases / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies
chemical_list: D002699:Chlorambucil; D011239:Prednisolone; D001379:Azathioprine