title: Pleomorphic lipoma of the tongue as potential mimic of liposarcoma.
abstract: We herein report a rare case of pleomorphic lipoma of the tongue with a review of world literature. A 44-year-old woman presented with a nodule of the tongue that had been present for over three years. Clinical examination revealed a yellowish sub-mucosal lesion, measuring 3 cm in maximum diameter, protruding from lingual surface. A first biopsy showed a lipomatous tumour composed of mature adipocytes intermingled with myxoid areas composed of spindle uniform in size and shape and multinucleated floret-like giant cells. Spindle and giant cells were positive for CD34. A diagnosis of pleomorphic lipoma was made. In view of the benign nature of this mass, it was de-bulked rather than completely excised in order to preserve swallowing function.
authors.affiliation: Department of Pathologic Anatomy and Oncology, A.O.U. "San Giovanni di Dio e Ruggi d'Aragona" via S. Leonardo, Salerno, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: D'Antonio
authors.forename: Giampiero
authors.initials: G
authors.lastname: Locatelli
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Liguori
authors.forename: Maria
authors.initials: M
authors.lastname: Addesso
keywords: Differential diagnosis; immunohistochemistry; pleomorphic lipoma