title: The biodistribution of gold nanoparticles designed for renal clearance.
abstract: Owing to their tunable optical properties and their high absorption cross-section of X- and γ-ray, gold nanostructures appear as promising agents for remotely controlled therapy. Since the efficiency of cancer therapy is not limited to the eradication of the tumour but rests also on the sparing of healthy tissue, a biodistribution study is required in order to determine whether the behaviour of the nanoparticles after intravenous injection is safe (no accumulation in healthy tissue, no uptake by phagocytic cell-rich organs (liver, spleen) and renal clearance). The biodistribution of Au@DTDTPA nanoparticles which are composed of a gold core and a DTDTPA (dithiolated polyaminocarboxylate) shell can be established by X-ray imaging (owing to the X-ray absorption of the gold core) and by magnetic resonance imaging (MRI) since the DTDTPA shell was designed for the immobilization of paramagnetic gadolinium ions. However scintigraphy appears better suited for a biodistribution study owing to a great sensitivity. The successful immobilization of radioelements ((99m)Tc, (111)In) in the DTDTPA shell, instead of gadolinium ions, renders possible the follow up of Au@DTDTPA by scintigraphy which showed that Au@DTDTPA nanoparticles exhibit a safe behaviour after intravenous injection to healthy rats.
authors.affiliation: Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS - UCBL, Université de Lyon, 22 Avenue Gaston Berger, 69622 Villeurbanne Cedex, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Alric
authors.forename: Imen
authors.initials: I
authors.lastname: Miladi
authors.forename: David
authors.initials: D
authors.lastname: Kryza
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Taleb
authors.forename: François
authors.initials: F
authors.lastname: Lux
authors.forename: Rana
authors.initials: R
authors.lastname: Bazzi
authors.forename: Claire
authors.initials: C
authors.lastname: Billotey
authors.forename: Marc
authors.initials: M
authors.lastname: Janier
authors.forename: Pascal
authors.initials: P
authors.lastname: Perriat
authors.forename: Stéphane
authors.initials: S
authors.lastname: Roux
authors.forename: Olivier
authors.initials: O
authors.lastname: Tillement
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D005682:Gadolinium / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006046:Gold / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D053768:Metal Nanoparticles; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000652:urine; D011877:Radionuclide Imaging / Q000379:methods; D051381:Rats; D011916:Rats, Inbred F344; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D006046:Gold; D005682:Gadolinium