title: Facile synthesis of tetrasaccharide aided by fluorous chemistry toward a dengue virus vaccine.
abstract: We report the synthesis of a tetrasaccharide with side chain using a light-fluorous-tagged glycosyl donor through the double glycosylation and gradient fluorous solid-phase extraction by adding a little of DCM to improve the solubility for retention for the first time. This convergent method has high efficacy by saving much time and solvent.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2 Nanwei Rd., Xicheng District, Beijing, 100050, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D003715:Dengue / Q000276:immunology / Q000517:prevention & control*; D053059:Dengue Vaccines / Q000138:chemical synthesis*; D003716:Dengue Virus / Q000187:drug effects / Q000276:immunology; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D009844:Oligosaccharides / Q000138:chemical synthesis*
chemical_list: D053059:Dengue Vaccines; D006020:Glycopeptides; D009844:Oligosaccharides