title: Aggressive local therapy combined with systemic chemotherapy provides long-term control in grade II stage 2 canine mast cell tumour: 21 cases (1999-2012).
abstract: This retrospective case series evaluates the outcome of 21 dogs with grade II stage 2 mast cell tumour (MCT) treated with adequate local therapy and adjuvant systemic chemotherapy (prednisone, vinblastine and CCNU). The median survival for all dogs was 1359 days (range, 188-2340). Median disease-free interval was 2120 days (149-2325 days). Dogs treated with surgery and chemotherapy had shorter survival (median, 1103 days; 188-2010 days) than those that underwent surgery, radiation therapy and chemotherapy as part of their treatment (median, 2056 days; 300-2340 days). Two patients had local recurrence in the radiation field and four patients had de novo MCT. Distant metastasis was not observed in any dogs. The results of this study suggest that, in the presence of loco-regional lymph node metastasis in grade II MCT, the use of prednisone, vinblastine and CCNU after adequate local-regional therapy can provide a median survival in excess of 40 months.
authors.affiliation: Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Lejeune
authors.affiliation: Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.|Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, CA, USA.
authors.forename: K
authors.initials: K
authors.lastname: Skorupski
authors.affiliation: Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.|Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, CA, USA.|Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA.
authors.forename: S
authors.initials: S
authors.lastname: Frazier
authors.affiliation: Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.|Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
authors.forename: I
authors.initials: I
authors.lastname: Vanhaezebrouck
authors.affiliation: Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.|Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, CA, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Rebhun
authors.affiliation: Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.|Department of Veterinary Pathology, Microbiology and Immunology, University of California, Davis, CA, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Reilly
authors.affiliation: Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.|Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, CA, USA.
authors.forename: C O
authors.initials: CO
authors.lastname: Rodriguez
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use*; D002140:California; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D005260:Female; D008130:Lomustine / Q000494:pharmacology / Q000627:therapeutic use*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D012515:Mast-Cell Sarcoma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D009367:Neoplasm Staging; D011241:Prednisone / Q000494:pharmacology / Q000627:therapeutic use*; D012189:Retrospective Studies; D014747:Vinblastine / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D018931:Antineoplastic Agents, Hormonal; D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D008130:Lomustine; D011241:Prednisone
keywords: canine; chemotherapy; mast cell tumour; radiation therapy; surgery