title: RNA-guided diagnostics and therapeutics for next-generation individualized nanomedicine.
abstract: The absence of reliable quantitative laboratory tests for measurements of microRNAs and other classes of small noncoding RNAs in archived, formalin- fixed, paraffin-embedded human samples with sufficient specificity and sensitivity has significantly limited the development of clinically relevant noncoding RNA–based diagnostic and therapeutic applications. A report by Renwick et al. in this issue of the JCI presents a significant technical and methodological advance toward the development of reliable clinical laboratory- compatible multicolor RNA FISH methodology for molecular diagnostic applications and the near-term prospect of introduction of microRNA- based biomarkers into clinical practice. Further, this work is likely to advance the development of RNA-based therapeutics and next-generation individualized nanomedicine.
authors.affiliation: Sanford-Burnham Medical Research Institute, La Jolla, California, USA. gglinsky@stanford.edu
authors.forename: Gennadi V
authors.initials: GV
authors.lastname: Glinsky
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002280:Basal Cell Carcinoma / Q000175:diagnosis*; D015266:Carcinoma, Merkel Cell / Q000175:diagnosis*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D012878:Skin Neoplasms / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; C534425:MIR205, human; C540933:MIRN375 microRNA, human