title: Hypotriglyceridemic potential of fermented mixed tea made with third-crop green tea leaves and camellia (Camellia japonica) leaves in Sprague-Dawley rats.
abstract: Fermented mixed tea made with third-crop green tea leaves and camellia leaves by a tea-rolling process has been developed. The objective of this study was to investigate hypotriglyceridemic potential of the mixed tea in rats. The mixed tea contained theasinensins and theaflavins. Rats fed the mixed tea extract at the level of 1% exerted significantly lower body weight and adipose tissue weight compared to animals fed third-crop green tea or camellia tea extract alone for 4 weeks. Serum and hepatic triglyceride was significantly and dose-dependently decreased by the mixed tea. This decrease was associated with lowered lipogenic enzyme activities in the liver. Furthermore, an oral administration of 4 or 8% of the mixed tea extract followed by fat emulsion suppressed the increment of serum triglyceride level. These results suggest that the mixed tea has hypotriglyceridemic action, partially via delaying triglyceride absorption in the small intestine and repressing hepatic lipogenic enzymes.
authors.affiliation: Department of Nutrition, University of Nagasaki , 1-1-1 Manabino, Nagayo-cho, Nishisonogi-gun, Nagasaki 851-2195, Japan.
authors.forename: Shizuka
authors.initials: S
authors.lastname: Tamaru
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ohmachi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Miyata
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Kubayasi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nagata
authors.forename: Kazunari
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000737:chemistry / Q000627:therapeutic use; D001578:Benzopyrans / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use; D044946:Biflavonoids / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use; D028244:Camellia / Q000737:chemistry* / Q000254:growth & development; D028241:Camellia sinensis / Q000737:chemistry* / Q000254:growth & development; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000032:analysis / Q000627:therapeutic use; D018556:Crops, Agricultural / Q000737:chemistry* / Q000254:growth & development; D005285:Fermentation; D005511:Food Handling; D015228:Hypertriglyceridemia / Q000097:blood / Q000378:metabolism / Q000517:prevention & control; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D007408:Intestinal Absorption; D007564:Japan; D050177:Overweight / Q000097:blood / Q000378:metabolism / Q000517:prevention & control; D010636:Phenols / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry / Q000254:growth & development; D051381:Rats; D017207:Rats, Sprague-Dawley; D013662:Tea / Q000737:chemistry; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism
chemical_list: D019440:Anti-Obesity Agents; D001578:Benzopyrans; D044946:Biflavonoids; D000960:Hypolipidemic Agents; D010636:Phenols; D013662:Tea; D014280:Triglycerides; C576796:epigallocatechin-3-O-gallate epigallocatechin dimer; C481298:theasinensin A; C056068:theaflavin; D002392:Catechin