title: Acute dystonia, akathisia, and parkinsonism induced by ziprasidone.
abstract: Ziprasidone is a second-generation antipsychotic with a lower propensity to cause extrapyramidal adverse effects that are seen at higher doses. We report a patient who developed acute dystonia, parkinsonism, and severe akathisia with ziprasidone 80 mg/d. These adverse effects subsided after dose reduction and specific treatment for akathisia and parkinsonism.
authors.affiliation: 1Department of Psychiatry, Kasturba Medical College, Manipal, Karnataka, India; 2Department of Psychiatry, KPC Medical College and Hospital, Jadavpur, Kolkata, India; 3Department of Psychiatry, Institute of Psychiatry, Institute of Postgraduate Medical Education and Research (IPGMER), Kolkata, India; and 4Department of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India.
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Praharaj
authors.forename: Amlan Kusum
authors.initials: AK
authors.lastname: Jana
authors.forename: Sujit
authors.initials: S
authors.lastname: Sarkhel
authors.forename: Vinod Kumar
authors.initials: VK
authors.lastname: Sinha
mesh_terms: D000208:Acute Disease; D000328:Adult; D017109:Akathisia, Drug-Induced / Q000209:etiology*; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004421:Dystonia / Q000139:chemically induced*; D006801:Humans; D008297:Male; D020734:Parkinsonian Disorders / Q000139:chemically induced*; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects*; D013844:Thiazoles / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014150:Antipsychotic Agents; D010879:Piperazines; D013844:Thiazoles; C092292:ziprasidone