title: The impact of commercialisation on public perceptions of stem cell research: exploring differences across the use of induced pluripotent cells, human and animal embryos.
abstract: The development of pluripotent cells that enable stem cell research (SCR) without destroying human embryos is now a leading priority for science. Public and political controversies associated with human embryonic SCR experienced in the recent past should be alleviated if scientists no longer need to harvest cells from human embryos. This research suggests however additional issues needing attention in order to gain the public's trust and support: the use of mouse embryos and the commercialisation of research. Using a representative sample of 2,800 Australians, and an experimental telephone survey design, this research compared levels and predictors of public support for stem cell research across three cell source conditions: human embryo (HE), mouse embryo (ME) and induced pluripotent cells (iPSCs). The results revealed that the public were significantly more likely to support research using iPSCs than HE and ME cells and public compared to private research (regardless of the cell source). There was no significant difference in support for HE compared to ME research, but the former was viewed as more likely to lead to accessible health care benefits and to be associated with more trustworthy scientists. The results of a multimediation structural equation model showed that the primary reason support for SCR significantly dropped in a private compared to public context (i.e., the commercialisation effect) was because public scientists were trusted more than private scientists. This effect was consistent across all three SCR materials, suggesting that the use of mouse embryos or even iPSCs will not reduce the publics' concern with commercialised science. The implications these results have for public acceptance of stem cell and animal research are discussed in relation to possible solutions such as increasing public awareness of the regulation of animal research and benefit sharing.
authors.affiliation: Faculty of Life and Social Sciences, Swinburne University of Technology, P.O. Box 218, Mail number: H31, Hawthorn, Victoria, 3123, Australia, ccritchley@swin.edu.au.
authors.forename: Christine R
authors.initials: CR
authors.lastname: Critchley
authors.forename: Gordana
authors.initials: G
authors.lastname: Bruce
authors.forename: Matthew
authors.initials: M
authors.lastname: Farrugia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001315:Australia; D003625:Data Collection / Q000379:methods / Q000706:statistics & numerical data; D033041:Embryo Research / Q000941:ethics*; D053595:Embryonic Stem Cells / Q000166:cytology; D005260:Female; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D008297:Male; D051379:Mice; D008875:Middle Aged; D011639:Public Opinion; D057905:Stem Cell Research / Q000941:ethics*; D018581:Technology Transfer; D055815:Young Adult