title: Solvent-free synthesis of functionalized thiazoles using multicomponent reaction of isothiocyanates.
abstract: An efficient synthesis of thiazoles is described via an one-pot reaction between acid chlorides, ammonium thiocyanate tetramethylguanidine and α-bromocarbonyl compounds under solvent-free conditions without using any catalyst. The method offers several advantages including high yields of products and an easy work-up procedure at room temperature in excellent yield.
authors.affiliation: Department of Chemistry, Azadshahr Branch, Islamic Azad University, Azadshahr, Iran. zalangi@gmail.com.
authors.forename: Seyyedeh Zahra
authors.initials: SZ
authors.lastname: Sayyed-Alangi
authors.forename: Zinatossadat
authors.initials: Z
authors.lastname: Hossaini
authors.forename: Faramarz
authors.initials: F
authors.lastname: Rostami-Charati
authors.forename: Hadi
authors.initials: H
authors.lastname: Sajjadi-Ghotabadi
mesh_terms: D002712:Chlorides / Q000737:chemistry; D006146:Guanidines / Q000737:chemistry; D017879:Isothiocyanates / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D002712:Chlorides; D006146:Guanidines; D017879:Isothiocyanates; D013844:Thiazoles; C037152:isothiocyanic acid; C477069:1,1,3,3-tetramethylguanidine