title: [The expression and clinical implication of plasma miR-328 in patients with atrial fibrillation].
abstract: OBJECTIVE
  To observe the expression and clinical implication of plasma miR-328 in patients with atrial fibrillation (AF).
  
  
  METHODS
  Fifty-eight patients with AF (AF group: 17 paroxysmal AF, 21 persistent AF, and 20 permanent AF) and 15 healthy volunteers (Control group) were included. General clinical data and related biochemical parameters were collected. Plasma miR-328 levels were detected with quantitative real-time polymerase chain reaction (qRT-PCR) analysis. The correlation between plasma miR-328 and AF risk factors was analyzed.
  
  
  RESULTS
  (1) Compared with the control group, the expression level of plasma miR-328 was significantly elevated in AF group (fold 7.72 ± 9.32) (P < 0.05). (2) In AF group, the expression of plasma miR-328 was significantly different in different type of AF[paroxysmal AF with (1.98 ± 0.81), persistent AF with (6.57 ± 5.82) and permanent AF with (13.47 ± 12.29)] (P < 0.05), and which was increased in proportion to the duration of AF. (3) There was a positive correlation between plasma miR-328 level and left atrial diameter in the AF group (r = 0.310, P < 0.05).
  
  
  CONCLUSIONS
  miR-328 expression is significantly increased in patients with AF, which may be involved in the atrial remodeling process of AF.
authors.affiliation: Cardiovascular Department, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.forename: Chun-guang
authors.initials: CG
authors.lastname: Qiu
authors.forename: Zhen-wen
authors.initials: ZW
authors.lastname: Huang
authors.forename: Zhan-ying
authors.initials: ZY
authors.lastname: Han
authors.forename: Wen-jie
authors.initials: WJ
authors.lastname: Lu
authors.forename: Xiao-jie
authors.initials: XJ
authors.lastname: Chen
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged
chemical_list: C548170:MIRN328 microRNA, human; D035683:MicroRNAs