title: Anticlastogenic activity of flavonoid rich extract of Cassia auriculata Linn. on experimental animal [corrected].
abstract: OBJECTIVE
  To determine antimutagenic activity of Cassia auriculata Linn. on chromosomal damage induced by cyclophosphamide (CP).
  
  
  METHODS
  In the present investigation, four groups of six Swiss albino mice in each group were used. Excepting for the first group all the remaining groups were treated with CP (50 mg/kg). Mice of third and fourth group were treated with ethyl acetate extract of C. auriculata Linn. at 100 mg/kg and 200 mg/kg with CP. Metaphase of bone marrow cells of all animals were analyzed for qualitative and quantitative chromosomal aberrations. Break, fragment, deletion, Polyploidy, pulverized, ring and total aberration were observed.
  
  
  RESULTS
  Flavonoids rich extracts of root of C. auriculata Linn. provided significant protection (P < 0.05) against CP induced chromosomal aberration. Total chromosomal aberration was found to be 12.16 and 7.33% in 100 and 200 mg/kg of extract treated animals respectively.
  
  
  CONCLUSIONS
  From the present study it can was observed that ethyl acetate extract of C. auriculata Linn possess significant anti-mutagenic potential against CP induced chromosomal aberration.
authors.affiliation: Dr. Punjabrao Medical College, Amravati, India.
authors.forename: Supriya S
authors.initials: SS
authors.lastname: Deshpande
authors.forename: Shailesh M
authors.initials: SM
authors.lastname: Kewatkar
authors.forename: Vivek V
authors.initials: VV
authors.lastname: Paithankar
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects*; D002366:Cassia / Q000737:chemistry*; D002869:Chromosome Aberrations / Q000187:drug effects*; D025063:Chromosome Disorders / Q000517:prevention & control*; D003520:Cyclophosphamide / Q000633:toxicity*; D005419:Flavonoids / Q000494:pharmacology*; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation
chemical_list: D016587:Antimutagenic Agents; D005419:Flavonoids; D009153:Mutagens; D010936:Plant Extracts; D003520:Cyclophosphamide
keywords: Bone marrow cells; Cassia auriculata Linn; cyclophosphamide