title: [Regulation of osteoblastic differentiation by Wnt signals].
abstract: Wnt signaling system controls diverse biological phenomena through development and adulthood of all animals. Canonical Wnt signaling is well characterized and its defect causes abnormalities in bone metabolism. Furthermore, Wnt5a, a typical non-canonical ligand, has been shown to play an important role in osteoblast differentiation. In addition, recent studies have revealed that LRP5 regulates bone mass by inhibiting duodenal synthesis of serotonin.
authors.affiliation: Department of Internal Medicine, Keio University, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Fukuda
authors.forename: Shu
authors.initials: S
authors.lastname: Takeda
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D060492:Low Density Lipoprotein Receptor-Related Protein-5 / Q000378:metabolism; D010006:Osteoblasts / Q000166:cytology* / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*
chemical_list: D060492:Low Density Lipoprotein Receptor-Related Protein-5; D051153:Wnt Proteins