title: Human prostatic acid phosphatase: structure, function and regulation.
abstract: Human prostatic acid phosphatase (PAcP) is a 100 kDa glycoprotein composed of two subunits. Recent advances demonstrate that cellular PAcP (cPAcP) functions as a protein tyrosine phosphatase by dephosphorylating ErbB-2/Neu/HER-2 at the phosphotyrosine residues in prostate cancer (PCa) cells, which results in reduced tumorigenicity. Further, the interaction of cPAcP and ErbB-2 regulates androgen sensitivity of PCa cells. Knockdown of cPAcP expression allows androgen-sensitive PCa cells to develop the castration-resistant phenotype, where cells proliferate under an androgen-reduced condition. Thus, cPAcP has a significant influence on PCa cell growth. Interestingly, promoter analysis suggests that PAcP expression can be regulated by NF-κB, via a novel binding sequence in an androgen-independent manner. Further understanding of PAcP function and regulation of expression will have a significant impact on understanding PCa progression and therapy.
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA. mlin@unmc.edu.
authors.forename: Sakthivel
authors.initials: S
authors.lastname: Muniyan
authors.forename: Nagendra K
authors.initials: NK
authors.lastname: Chaturvedi
authors.forename: Jennifer G
authors.initials: JG
authors.lastname: Dwyer
authors.forename: Chad A
authors.initials: CA
authors.lastname: Lagrange
authors.forename: William G
authors.initials: WG
authors.lastname: Chaney
authors.forename: Ming-Fong
authors.initials: MF
authors.lastname: Lin
mesh_terms: D000135:Acid Phosphatase / Q000235:genetics* / Q000378:metabolism; D000595:Amino Acid Sequence; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008297:Male; D008957:Models, Genetic; D008969:Molecular Sequence Data; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D000135:Acid Phosphatase; C428439:prostatic acid phosphatase