title: Engineering plant disease resistance based on TAL effectors.
abstract: Transcription activator-like (TAL) effectors are encoded by plant-pathogenic bacteria and induce expression of plant host genes. TAL effectors bind DNA on the basis of a unique code that specifies binding of amino acid residues in repeat units to particular DNA bases in a one-to-one correspondence. This code can be used to predict binding sites of natural TAL effectors and to design novel synthetic DNA-binding domains for targeted genome manipulation. Natural mechanisms of resistance in plants against TAL effector-containing pathogens have given insights into new strategies for disease control.
authors.affiliation: Sainsbury Laboratory, University of Cambridge, Cambridge, CB2 1LR, United Kingdom.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Schornack
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Moscou
authors.forename: Eric R
authors.initials: ER
authors.lastname: Ward
authors.forename: Diana M
authors.initials: DM
authors.lastname: Horvath
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D018556:Crops, Agricultural / Q000235:genetics / Q000276:immunology / Q000382:microbiology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D060467:Disease Resistance; D005818:Genetic Engineering; D008958:Models, Molecular; D010935:Plant Diseases / Q000276:immunology* / Q000382:microbiology; D014774:Virulence; D014974:Xanthomonas / Q000235:genetics / Q000472:pathogenicity*
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins