title: Involvement of the novel two-component NsrRS and LcrRS systems in distinct resistance pathways against nisin A and nukacin ISK-1 in Streptococcus mutans.
abstract: The novel two-component systems NsrRS and LcrRS are individually associated with resistance against the distinct lantibiotics nisin A and nukacin ISK-1 in Streptococcus mutans. NsrRS regulates the expression of NsrX, which is associated with nisin A binding, and LcrRS regulates the expression of the ABC transporter LctFEG.
authors.affiliation: Department of Oral Microbiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Kawada-Matsuo
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oogai
authors.forename: Takeshi
authors.initials: T
authors.lastname: Zendo
authors.forename: Junichi
authors.initials: J
authors.lastname: Nagao
authors.forename: Yukie
authors.initials: Y
authors.lastname: Shibata
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Yoshitoshi
authors.initials: Y
authors.lastname: Ogura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hayashi
authors.forename: Kenji
authors.initials: K
authors.lastname: Sonomoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Komatsuzawa
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D001430:Bacteriocins / Q000235:genetics* / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D009561:Nisin / Q000235:genetics* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D013295:Streptococcus mutans / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism
chemical_list: D018528:ATP-Binding Cassette Transporters; D001430:Bacteriocins; C421186:nukacin ISK-1; D009561:Nisin; C102526:nisin A