title: Sarcoid arthropathy and the association with the human leukocyte antigen. The Icelandic Sarcoidosis Study.
abstract: OBJECTIVE
  The aim of the present study was to evaluate whether certain HLA antigens were risk factors for developing sarcoid arthritis and whether HLA antigens appear to account for the phenotype and the resolution of the arthritis condition in an unselected nationwide cohort.
  
  
  METHODS
  The Icelandic Sarcoidosis Study (ISS) contains all tissue-verified cases of sarcoidosis in Iceland since 1981. Of a total of 234 cases, 39 patients were identified with arthritis and of those 36 delivered a biosample for the study. The patient cohort has previously been described in detail. DNA was isolated from EDTA blood and HLA antigen typing was performed. A total of 544 Icelandic stem cell donors acted as controls.
  
  
  RESULTS
  HLA-B8 and HLA-B14 antigens were more common among those who suffered from sarcoid arthritis (24% vs. 11%, p<0.01; 6.5% vs. 2.4%, p<0.05). DRB1*03 was also found more frequently in patients with sarcoid arthritis compared to controls (28% vs. 11%, p<0.001), while DRB1*04 was less frequently reported (5.6% vs. 17%, p<0.01). No differences were found in the HLA-A distribution between the groups. A higher proportion of patients with chronic arthritis had HLA-A11 than those with resolving joint problems (60% vs. 3.8%).
  
  
  CONCLUSIONS
  Our nationwide study of patients with sarcoid arthritis further supports the conclusion that genetics may strongly influence the development and the clinical course of the disease. Furthermore, some HLA antigens may even be protective for the disease. Thus, classification of the major histocompatibility complex may have clinical implications.
authors.affiliation: Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland. dyrleifpetursdottir@gmail.com.
authors.forename: Dyrleif
authors.initials: D
authors.lastname: Petursdottir
authors.forename: Sigridur Olina
authors.initials: SO
authors.lastname: Haraldsdottir
authors.forename: Kristjana
authors.initials: K
authors.lastname: Bjarnadottir
authors.forename: Thorbjorn
authors.initials: T
authors.lastname: Jonsson
authors.forename: Thorarinn
authors.initials: T
authors.lastname: Gislason
authors.forename: Sveinn
authors.initials: S
authors.lastname: Gudmundsson
authors.forename: Bjorn
authors.initials: B
authors.lastname: Gudbjornsson
mesh_terms: D000328:Adult; D001168:Arthritis / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors; D012507:Sarcoidosis / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens