title: Cytotoxic phorbol esters of Croton tiglium.
abstract: Chemical investigation of the seeds of Croton tiglium afforded eight new phorbol diesters (three phorbol diesters, 1-3, and five 4-deoxy-4α-phorbol diesters, 4-8), together with 11 known phorbol diesters (nine phorbol diesters, 9-17, and two 4-deoxy-4α-phorbol diesters, 18 and 19). The structures of compounds 1-8 were determined by spectroscopic data information and chemical degradation experiments. The cytotoxic activities of the phorbol diesters were evaluated against the SNU387 hepatic tumor cell line, and compound 3 exhibited the most potent activity (IC50 1.2 μM).
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation, Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People's Republic of China.
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Zhang
authors.forename: Lun
authors.initials: L
authors.lastname: Wang
authors.forename: Fu
authors.initials: F
authors.lastname: Li
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.forename: Ming-Kui
authors.initials: MK
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029802:Croton / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008113:Liver Neoplasms / Q000188:drug therapy; D015394:Molecular Structure; D010703:Phorbol Esters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry
chemical_list: C582890:13-O-acetylphorbol-20-oleate; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D010703:Phorbol Esters