title: Near-infrared light-triggered micelles for fast controlled drug release in deep tissue.
abstract: In this manuscript, a near-infrared (NIR) light-breakable amphiphilic block copolymer N-succinyl-N'-4-(2-nitrobenzyloxy)-succinyl-chitosan micelles (SNSC), containing light-sensitive triggering group 2-nitrobenzyl alcohol on the hydrophobic block, was developed. The UV-Vis absorption spectra, Fourier Transform Infrared (FTIR) spectra, and (1)H nuclear magnetic resonance ((1)H NMR) spectra were characterized to confirm the successful synthesis of the micelles. Two-photon photolysis of SNSC micelles was displayed by transmission electron microscopy (TEM). By encapsulating a NIR dye cypate (Ex/Em: 780/808 nm) into the hydrophobic core of the micelles, the dissociation of the micelles under NIR illumination was greatly accelerated, enabling a controlled fast release of co-loaded hydrophobic species in the micelles. In vivo distribution and acute toxicity of the NIR light-sensitive micelles were also investigated to verify the low cytotoxicity of the micelles. Results indicate that this system provides an efficient method to surmount the drawback of UV or visible light-responsive polymeric systems for controlled drug release in deep tissues.
authors.affiliation: Department of Biomedical Engineering, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Cao
authors.forename: Shanshan
authors.initials: S
authors.lastname: Huang
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Chen
authors.forename: Siwen
authors.initials: S
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Dawei
authors.initials: D
authors.lastname: Deng
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Qian
authors.forename: Liping
authors.initials: L
authors.lastname: Tang
authors.forename: Yueqing
authors.initials: Y
authors.lastname: Gu
mesh_terms: D000818:Animals; D001592:Benzyl Alcohols / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D045744:Cell Line, Tumor; D048271:Chitosan / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D007259:Infrared Rays; D008099:Liver / Q000187:drug effects / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D008823:Micelles; D010782:Photolysis
chemical_list: D001592:Benzyl Alcohols; D003692:Delayed-Action Preparations; D008823:Micelles; C046887:2-nitrobenzyl alcohol; D048271:Chitosan