title: Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria.
abstract: JP4-039 is a lead structure in a series of nitroxide conjugates that are capable of accumulating in mitochondria and scavenging reactive oxygen species (ROS). To explore structure-activity relationships (SAR), new analogs with variable nitroxide moieties were prepared. Furthermore, fluorophore-tagged analogs were synthesized and provided the opportunity for visualization in mitochondria. All analogs were tested for radioprotective and radiomitigative effects in 32Dcl3 cells.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
authors.forename: Marie-Céline
authors.initials: MC
authors.lastname: Frantz
authors.forename: Erin M
authors.initials: EM
authors.lastname: Skoda
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Sacher
authors.forename: Michael W
authors.initials: MW
authors.lastname: Epperly
authors.forename: Julie P
authors.initials: JP
authors.lastname: Goff
authors.forename: Joel S
authors.initials: JS
authors.lastname: Greenberger
authors.forename: Peter
authors.initials: P
authors.lastname: Wipf
mesh_terms: D001896:Boron Compounds / Q000032:analysis*; D002460:Cell Line; D005456:Fluorescent Dyes / Q000032:analysis*; D016166:Free Radical Scavengers / Q000032:analysis* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure*; D008958:Models, Molecular; D009589:Nitrogen Oxides / Q000032:analysis* / Q000138:chemical synthesis / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000032:analysis* / Q000138:chemical synthesis / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000032:analysis* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D016166:Free Radical Scavengers; C544775:JP4-039; D009589:Nitrogen Oxides; D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents