title: [An epidemiological survey of the prevalence of thyroid diseases in mild iodine deficiency city after salt iodization].
abstract: OBJECTIVE
  To investigate the current status of iodine nutrition and the prevalence of thyroid diseases in Guiyang, a mild iodine deficiency city practiced salt iodization for 25 years.
  
  
  METHODS
  A representative sample of 1509 adults aged 20 years old or above in Guiyang, selected by a multistage stratified sampling method, participated in the study. After an overnight fasting, serum thyroid hormones, serum thyroid autoantibodies, and urine iodine were measured. B-mode ultrasonography of the thyroid was performed in the population. Meanwhile, urine iodine of 80 children aged 8 - 10 years old in the same community were measured after an overnight fasting.
  
  
  RESULTS
  The median of 8-10 years old children's urinary iodine was 228.7 µg/L. The prevalence of overt hypothyroidism, subclinical hypothyroidism, overt hyperthyroidism and subclinical hyperthyroidism was 1.79%, 14.12%, 1.52% and 1.06% respectively. The prevalence of subclinical hypothyroidism was significantly higher than overt hypothyroidism (P < 0.05) and was significantly higher in female than that in male (P < 0.05). The prevalence of positive thyroid peroxidase antibody, positive thyroglobulin antibody and autoimmune thyroiditis was 14.38%, 13.59% and 4.44% respectively, which were significantly higher in female than that in male (all P values < 0.05). The prevalence of diffuse goiter and nodular goiter was 0.86% and 0.20% respectively, with a significant difference (P < 0.05).
  
  
  CONCLUSIONS
  After 25 years of salt iodization, the iodine nutrition in Guiyang is more than adequate with high prevalence of overt hypothyroidism, subclinical hypothyroidism and autoimmune thyroiditis.
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: Nian-chun
authors.initials: NC
authors.lastname: Peng
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Shi
authors.forename: Qiao
authors.initials: Q
authors.lastname: Zhang
authors.forename: Shu-jing
authors.initials: SJ
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.forename: Song
authors.initials: S
authors.lastname: Zhang
authors.forename: Hui-jun
authors.initials: HJ
authors.lastname: Zhuang
authors.forename: Ming-xian
authors.initials: MX
authors.lastname: Gong
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Dan-rong
authors.initials: DR
authors.lastname: Wu
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007455:Iodine / Q000008:administration & dosage / Q000172:deficiency*; D008297:Male; D008875:Middle Aged; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*; D013959:Thyroid Diseases / Q000453:epidemiology* / Q000517:prevention & control; D055815:Young Adult
chemical_list: D017673:Sodium Chloride, Dietary; C034024:iodized salt; D007455:Iodine