title: [Effect of chronic sensorineural hearing loss on several indicators of immune and endocrine systems of 7-11 year-old children].
abstract: We investigated the effects of chronic bilateral sensorineural hearing loss of III-IV degree on the performance of interleukins, immunoglobulins serum and saliva, the functional activity of granulocyte-monocyte cell immunity, evaluated the activity of the hypothalamic-pituitary-adrenal system in children aged 7-11 years. It was found that due to stress activation of the sympathetic-adrenal system the function of granulocytes and monocytes is suppressed, with a predominance of production of anti-inflammatory interleukins. This leads to the dominance of T-helper type 2. Products granulocytes and T-helper type-2 anti-inflammatory interleukins IL-4, IL-5, IL-10, IL-13 leads to the activation of B-cells. Thus, in children 7-11 years of age with congenital bilateral sensorineural hearing loss is a decrease of non-specific humoral immunity dominated type of immune response to increased levels of IgG.
authors.forename: S P
authors.initials: SP
authors.lastname: Beschasnyĭ
mesh_terms: D015068:17-Ketosteroids / Q000652:urine; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002648:Child; D016207:Cytokines / Q000097:blood / Q000276:immunology*; D004837:Epinephrine / Q000652:urine; D005260:Female; D006098:Granulocytes / Q000276:immunology / Q000473:pathology; D006319:Hearing Loss, Sensorineural / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000276:immunology* / Q000473:pathology; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000276:immunology / Q000473:pathology; D010587:Phagocytosis / Q000276:immunology; D010913:Pituitary-Adrenal System / Q000276:immunology* / Q000473:pathology; D012463:Saliva / Q000737:chemistry; D058408:Th1-Th2 Balance
chemical_list: D015068:17-Ketosteroids; D016207:Cytokines; D007074:Immunoglobulin G; D004837:Epinephrine