title: Effectiveness of a sealant compared with no sealant in preventing enamel demineralization in patients with fixed orthodontic appliances: a prospective clinical trial.
abstract: BACKGROUND
  In this study, we tested the efficacy of a tooth sealant polish (Biscover LV; Bisco, Schaumberg, Ill) to prevent enamel demineralization (white spot lesions) for the full duration of orthodontic treatment with fixed appliances. The trial design was an alternating-tooth split-mouth design.
  
  
  METHODS
  Patients starting treatment with bonded appliances in a private practice were enrolled. The 6 maxillary anterior teeth received the test sealant or no sealant. The nonblinded orthodontists visually examined the teeth immediately after debonding and rated the presence and severity of white spot lesions using a 4-point scale. The difference in incidence of white spot lesions on treated and control teeth was tested with multivariate binary logistic regression for repeated measures by using the generalized estimating equations approach.
  
  
  RESULTS
  Sixty-five subjects were enrolled, and 3 were lost to follow-up, leaving 62 for analysis. There was a slightly lower incidence of white spot lesions on treated teeth (13.5%; 95% confidence interval, 8.6-18.4) compared with the control teeth (17.7%; 95% confidence interval, 12.4-23.7). This difference was statistically significant in the multivariate model (Wald chi-square, 5.07; df = 1; P = 0.024). The odds ratio was equal to 0.68 (95% confidence interval, 0.47-0.95) that treated teeth would show white spot lesions relative to the control teeth. White spot lesion severity was nearly the same for treated and control teeth (mean ± SD = 1.17 ± 0.47 and 1.20 ± 0.48, respectively; Wald chi-square, 3.03; df = 1; P = 0.082). No serious adverse effects were reported.
  
  
  CONCLUSIONS
  The sealant did not prevent all white spot lesions for the full duration of treatment. The sealant demonstrated a clinically small but statistically significant ability to prevent white spot lesions.
authors.affiliation: 50 Wimbledon Way, Marlton, NJ 08053, USA. bhisabela@aol.com
authors.forename: Maria T
authors.initials: MT
authors.lastname: O'Reilly
authors.forename: Jaime
authors.initials: J
authors.lastname: De Jesús Viñas
authors.forename: John P
authors.initials: JP
authors.lastname: Hatch
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D000179:Acrylates / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D002327:Cariostatic Agents / Q000627:therapeutic use; D002648:Child; D055812:Community-Based Participatory Research; D003481:Cuspid / Q000187:drug effects; D001840:Dental Bonding; D003731:Dental Caries / Q000145:classification / Q000517:prevention & control; D003738:Dental Cements / Q000737:chemistry; D003743:Dental Enamel / Q000187:drug effects*; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D007180:Incisor / Q000187:drug effects; D008297:Male; D009910:Oral Hygiene; D016910:Orthodontic Brackets; D010895:Pit and Fissure Sealants / Q000627:therapeutic use*; D011446:Prospective Studies; D019279:Resin Cements / Q000627:therapeutic use; D017001:Tooth Demineralization / Q000145:classification / Q000517:prevention & control*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000179:Acrylates; C481141:BisCover; D002327:Cariostatic Agents; D003738:Dental Cements; D010895:Pit and Fissure Sealants; D019279:Resin Cements; D005459:Fluorides