title: A new polyketide from Diaporthe sp. SXZ-19, an endophytic fungal strain of Camptotheca acuminate.
abstract: A new polyketide named (1R,2E,4S,5R)-1-[(2R)-5-oxotetrahydrofuran-2-yl]-4,5-dihydroxy-hex-2-en-1-yl(2E)-2-methylbut-2-enoate (1), along with eight known polyketide including one monoterpene (2), three linear furanopolyketides (3-5) and four lovastatin analogues (6-9), was isolated from the endophytic fungal strain Diaporthe sp. SXZ-19 of Camptotheca acuminate. The chemical structures of compounds 1-9 were elucidated on the basis of extensive spectroscopic analyses, including FT-ICR-MS, IR and 1D and 2D NMR experiments. The in vitro cytotoxicity of 1 against the human colon cancer cell line HCT 116 was evaluated but showed no evident activity.
authors.affiliation: a Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences , Wuhan Hubei 430074 , P.R. China.
authors.forename: Yuanzhen
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Hu
authors.forename: Xiang
authors.initials: X
authors.lastname: Lin
authors.forename: Chunhua
authors.initials: C
authors.lastname: Lu
authors.forename: Yuemao
authors.initials: Y
authors.lastname: Shen
mesh_terms: D029769:Camptotheca / Q000382:microbiology*; D004354:Drug Screening Assays, Antitumor; D060026:Endophytes / Q000737:chemistry*; D045325:HCT116 Cells; D006801:Humans; D015394:Molecular Structure; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: C000590654:(1R,2E,4S,5R)-1-((2R)-5-oxotetrahydrofuran-2-yl)-4,5-dihydroxy-hex-2-en-1-yl(2E)-2-methylbut-2-enoate; D061065:Polyketides