title: Polyketides from a marine-derived fungus Xylariaceae sp.
abstract: Eighteen polyketides (1-18) including six citrinin derivatives, two phenol derivatives, one cyclopentenone, two naphthol derivatives, and seven tetralone derivatives were isolated from the culture broth of a marine-derived fungal strain Xylariaceae sp. SCSGAF0086. Five of these compounds (1, 2, 8, 9, and 10) were new, and their structures were determined by spectroscopic methods. Compounds 4, 6, 7, and 17 showed enzyme-inhibitory activities towards several tested enzymes, and 6 and 7 showed strong antifouling activity against Bugula neritina larvae settlement. This is the first time that the antifouling and enzyme-inhibitory activities of these compounds has been reported.
authors.affiliation: Key Laboratory of Marine Bio-Resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, Guangdong, China. shuhuaqi@scsio.ac.cn
authors.forename: Xu-Hua
authors.initials: XH
authors.lastname: Nong
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Zheng
authors.forename: Xiao-Yong
authors.initials: XY
authors.lastname: Zhang
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Lu
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Qi
mesh_terms: D000818:Animals; D057219:Biofouling / Q000517:prevention & control; D002013:Bryozoa / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis; D013098:Xylariales / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D061065:Polyketides