title: The emerging roles of 3' untranslated regions in cancer.
abstract: Accumulating evidence suggests that 3' untranlated regions (3' UTRs) are critical for spatial and temporal gene expression in both physiological and pathological conditions. The reprogramming of 3' UTRs by various means is a common phenomenon in cancer; disturbances of 3' UTRs significantly increase the risk of cancer susceptibility by acting both in cis and in trans. In this manuscript, we provide an update and perspective on recent advances made in understanding the emerging roles for 3' UTRs in cancer development and hint at the potential future applications of 3' UTRs in cancer diagnosis and therapy.
authors.affiliation: Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
mesh_terms: D020413:3' Untranslated Regions / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D026723:Polyadenylation
chemical_list: D020413:3' Untranslated Regions
keywords: 3′ Untranslated regions; Cancer; Competing endogenous RNA; MicroRNA; Posttranscriptional regulation