title: Pseudoephedrine for the treatment of clozapine-induced incontinence.
abstract: Clozapine, the first atypical antipsychotic, is well known for superior efficacy in the treatment of refractory schizophrenia. Though the side effect most often associated with clozapine is the potential for causing blood dyscrasias, other lesser known side effects, including clozapine-induced incontinence, may result in the unnecessary discontinuation of this essential psychiatric medication in patients who otherwise have no alternative to treatment. Here we describe a case of pseudoephedrine used successfully as a therapeutic intervention for clozapine-induced incontinence.
authors.affiliation: Drs. Hanes and Compos are from University at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Buffalo, New York; Drs. Demler and Lee are from Buffalo Psychiatric Center, Buffalo, New York.
authors.forename: Alicia
authors.initials: A
authors.lastname: Hanes
authors.forename: Tammie
authors.initials: T
authors.lastname: Lee Demler
authors.forename: Claudia
authors.initials: C
authors.lastname: Lee
authors.forename: Alexander
authors.initials: A
authors.lastname: Campos
keywords: Clozapine; Major depressive disorder; drug-induced; ephedrine; pseudoephedrine; urinary incontinence