title: An expanded view of the eukaryotic cytoskeleton.
abstract: A rich and ongoing history of cell biology research has defined the major polymer systems of the eukaryotic cytoskeleton. Recent studies have identified additional proteins that form filamentous structures in cells and can self-assemble into linear polymers when purified. This suggests that the eukaryotic cytoskeleton is an even more complex system than previously considered. In this essay, I examine the case for an expanded definition of the eukaryotic cytoskeleton and present a series of challenges for future work in this area.
authors.affiliation: Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
authors.forename: James B
authors.initials: JB
authors.lastname: Moseley
mesh_terms: D000199:Actins / Q000737:chemistry / Q000648:ultrastructure; D000818:Animals; D019731:Carbon-Nitrogen Ligases / Q000737:chemistry / Q000648:ultrastructure; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000648:ultrastructure; D003599:Cytoskeleton / Q000737:chemistry / Q000648:ultrastructure*; D004331:Drosophila melanogaster / Q000737:chemistry* / Q000166:cytology; D056827:Endosomal Sorting Complexes Required for Transport / Q000737:chemistry / Q000648:ultrastructure; D011992:Endosomes / Q000737:chemistry / Q000648:ultrastructure; D004926:Escherichia coli / Q000737:chemistry / Q000166:cytology; D005057:Eukaryotic Cells / Q000737:chemistry / Q000648:ultrastructure*; D006801:Humans; D055503:Protein Multimerization; D021381:Protein Transport; D012568:Schizosaccharomyces / Q000737:chemistry* / Q000166:cytology; D029702:Schizosaccharomyces pombe Proteins / Q000737:chemistry / Q000648:ultrastructure
chemical_list: D000199:Actins; D003598:Cytoskeletal Proteins; D056827:Endosomal Sorting Complexes Required for Transport; C570229:Pil1 protein, S pombe; D029702:Schizosaccharomyces pombe Proteins; D019731:Carbon-Nitrogen Ligases; C019951:CTP synthetase