title: Role of total artificial heart in the management of heart transplant rejection and retransplantation: case report and review.
abstract: Cardiac allograft rejection and failure may require mechanical circulatory support as bridge-to-retransplantation. Prognosis in this patient group is poor and implantable ventricular assist devices have had limited success due to organ failure associated with the high dose immunosuppression required to treat ongoing rejection. We present a case from our institution and the world-wide experience utilizing the SynCardia CardioWest Total Artificial Heart (TAH-t; SynCardia Systems, Inc., Tucson, AZ, USA) for replacement of the failing graft, recovery of patient and end-organ failure with ultimate bridge to retransplantation. We present our experience and review of world-wide experience for use of TAH-t in this type patient.
authors.affiliation: Division of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ 85054, USA. kalya.a@mayo.edu
authors.forename: Anantharam
authors.initials: A
authors.lastname: Kalya
authors.forename: Dawn
authors.initials: D
authors.lastname: Jaroszewski
authors.forename: Octavio
authors.initials: O
authors.lastname: Pajaro
authors.forename: Robert
authors.initials: R
authors.lastname: Scott
authors.forename: Radha
authors.initials: R
authors.lastname: Gopalan
authors.forename: Diane
authors.initials: D
authors.lastname: Kasper
authors.forename: Francisco
authors.initials: F
authors.lastname: Arabia
mesh_terms: D006084:Graft Rejection / Q000517:prevention & control*; D006331:Heart Diseases / Q000601:surgery*; D016027:Heart Transplantation; D006354:Heart, Artificial; D006801:Humans; D011379:Prognosis; D012086:Reoperation
keywords: cardiac rejection; heart transplant; immunosuppression; retransplantation; total artificial heart