title: Relationship between 2-deoxy-2-[(18)F]-fluoro-d-glucose uptake and clinicopathological factors in patients with diffuse large B-cell lymphoma.
abstract: The aim of this study was to investigate correlations between the standardized uptake value of the biopsy site (BSUVmax) and levels of glucose transporter (GLUT)-1, GLUT-3 and hexokinase-II (HK-II), between BSUVmax and the Ki-67 proliferation index (MIB-1), and between BSUVmax and clinicopathological factors. Sixty-eight patients with diffuse large B-cell lymphoma (DLBCL) were included in this study. BSUVmax was significantly correlated with GLUT-1, GLUT-3 and the International Prognostic Index (IPI) (GLUT-1: r = 0.584, IPI: r = 0.363, p < 0.001; GLUT-3: r = 0.369, p = 0.009; IPI: r = 0.363, p = 0.004), but not with MIB-1 and HK-II. A statistically significant correlation was observed between GLUT-3 expression and each of IPI and gene expression profiling (GEP) (IPI: p = 0.0186; GEP: p = 0.0179). 2-Deoxy-2-[(18)F]-fluoro-d-glucose (FDG) uptake was significantly correlated with the levels of GLUT-1 and GLUT-3 and with IPI. The results indicated that GLUT-3 expression is related to GEP and IPI, and that BSUVmax and GLUT-3 may have a relationship with the prognosis of DLBCL.
authors.affiliation: Department of Radiology, Kurume University School of Medicine , Kurume City, Fukuoka , Japan.
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Hirose
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Suefuji
authors.forename: Hayato
authors.initials: H
authors.lastname: Kaida
authors.forename: Masanobu
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hattori
authors.forename: Seiji
authors.initials: S
authors.lastname: Kurata
authors.forename: Yuko
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kunou
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kawahara
authors.forename: Takashi
authors.initials: T
authors.lastname: Okamura
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kage
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Ishibashi
authors.forename: Naofumi
authors.initials: N
authors.lastname: Hayabuchi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001692:Biological Transport; D002648:Child; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D051246:Glucose Transport Proteins, Facilitative / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D051246:Glucose Transport Proteins, Facilitative; D019788:Fluorodeoxyglucose F18