title: Expression pattern of the homeotic gene Bapx1 during early chick gastrointestinal tract development.
abstract: Regulation of the Bone Morphogenetic Protein (BMP) signaling pathway is essential for the normal development of vertebrate gastrointestinal (GI) tract, but also for the differentiation of the digestive mesenchymal layer into smooth muscles and submucosal layer. Different studies demonstrated that Bapx1 (for bagpipe homeobox homolog 1) negatively regulates the BMP pathway, but its precise expression pattern during the development and the differentiation of the GI tract mesenchyme actually remains to be examined. Here, we present the spatio-temporal expression profile of Bapx1 in the chick GI tract. We show that Bapx1 is first expressed in the undifferentiated mesenchyme of the gizzard and the colon. After the differentiation of the digestive mesenchyme, we found Bapx1 strongly expressed in the gizzard smooth muscle and in the submucosa layer of the colon. This expression pattern provides new insights into the roles of Bapx1 during the regionalization of the GI tract and the differentiation of the digestive mesenchyme of the colon and the stomach.
authors.affiliation: INSERM U1046, Université Montpellier 1, Université Montpellier 2, 371 Avenue Doyen Giraud, 34295 Montpellier, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Faure
authors.forename: Maxime
authors.initials: M
authors.lastname: Georges
authors.forename: Jennifer
authors.initials: J
authors.lastname: McKey
authors.forename: Sébastien
authors.initials: S
authors.lastname: Sagnol
authors.forename: Pascal
authors.initials: P
authors.lastname: de Santa Barbara
mesh_terms: D000818:Animals; D030161:Avian Proteins / Q000235:genetics* / Q000378:metabolism; D002642:Chick Embryo; D003106:Colon / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D005753:Gastric Mucosa / Q000196:embryology / Q000378:metabolism; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D005895:Gizzard, Avian / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000196:embryology / Q000378:metabolism; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D009928:Organ Specificity; D011708:Pylorus / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D012007:Rectum / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D030161:Avian Proteins; D014157:Transcription Factors
keywords: BMP pathway; Bapx1; Chick development; Gastrointestinal tract; Smooth muscle