title: Plasma levels and diagnostic value of catestatin in patients with heart failure.
abstract: Catestatin (CST) is an endogenous neuropeptide with multiple cardiovascular activities. The study is to investigate circulating CST levels in heart failure (HF) patients and to evaluate the role of CST as a biomarker for HF. Plasma CST concentrations were measured by enzyme-linked immunosorbent assay in 228 HF patients and 172 controls. Plasma CST gradually increased in patients from NYHA class I to class IV. No significant differences in CST were found among NYHA I, NYHA II patients and controls. Plasma CST in NYHA III and IV patients was higher compared to other groups. Plasma CST levels in HF patients after treatment were similar to admission, but still higher than controls. In a subgroup analysis among the patients with NYHA class III or IV, patients with ischemic etiology had significantly higher CST. Plasma CST levels were similar between patients with preserved and reduced ejection fraction. Multivariable analysis showed that NYHA classes, the etiology of HF (ischemic or not) and estimated glomerular filtration rate independently predicted plasma LogCST levels (P<0.05). The area under ROC for CST and BNP in moderate to severe HF diagnosis was 0.626 and 0.831, respectively, combining CST and BNP did not improve the accuracy.
authors.affiliation: Department of Cardiology, Peking University First Hospital, No. 1, Dahongluochang Street, West District, Beijing 100034, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.forename: Wenhui
authors.initials: W
authors.lastname: Ding
authors.forename: Renxu
authors.initials: R
authors.lastname: Li
authors.forename: Xiaojin
authors.initials: X
authors.lastname: Ye
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Jiang
authors.forename: Lei
authors.initials: L
authors.lastname: Meng
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Songyun
authors.initials: S
authors.lastname: Chu
authors.forename: Xiaoning
authors.initials: X
authors.lastname: Han
authors.forename: Fen
authors.initials: F
authors.lastname: Peng
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D053379:Chromogranin A / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D008297:Male; D009479:Neuropeptides / Q000097:blood; D010446:Peptide Fragments / Q000097:blood*; D013318:Stroke Volume / Q000502:physiology
chemical_list: D015415:Biomarkers; D053379:Chromogranin A; D009479:Neuropeptides; D010446:Peptide Fragments; C109084:chromogranin A (344-364)
keywords: Biomarker; Catestatin; Heart failure; Neuroendocrine