title: The effect of taurine on chronic heart failure: actions of taurine against catecholamine and angiotensin II.
abstract: Taurine, a ubiquitous endogenous sulfur-containing amino acid, possesses numerous pharmacological and physiological actions, including antioxidant activity, modulation of calcium homeostasis and antiapoptotic effects. There is mounting evidence supporting the utility of taurine as a pharmacological agent against heart disease, including chronic heart failure (CHF). In the past decade, angiotensin II blockade and β-adrenergic inhibition have served as the mainstay in the treatment of CHF. Both groups of pharmaceutical agents decrease mortality and improve the quality of life, a testament to the critical role of the sympathetic nervous system and the renin--angiotensin system in the development of CHF. Taurine has also attracted attention because it has beneficial actions in CHF, in part by its demonstrated inhibition of the harmful actions of the neurohumoral factors. In this review, we summarize the beneficial actions of taurine in CHF, focusing on its antagonism of the catecholamines and angiotensin II.
authors.affiliation: Department of Clinical Pharmacogenomics, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ito
authors.forename: Stephen
authors.initials: S
authors.lastname: Schaffer
authors.forename: Junichi
authors.initials: J
authors.lastname: Azuma
mesh_terms: D000804:Angiotensin II; D000818:Animals; D002395:Catecholamines / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002908:Chronic Disease; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D012084:Renin-Angiotensin System / Q000187:drug effects*; D013654:Taurine / Q000627:therapeutic use*
chemical_list: D002395:Catecholamines; D000804:Angiotensin II; D013654:Taurine