title: Chapter 7: Allergic fungal rhinosinusitis.
abstract: Allergic fungal rhinosinusitis (AFRS) is a type of chronic rhinosinusitis in which patients classically exhibit nasal polyps, type I IgE-mediated hypersensitivity, characteristic findings on computed tomography scans, eosinophilic mucin, and positive fungal stain. New research has sought to further understand the pathophysiology of AFRS. However, this has also led to debate about the classification and predominance of this interesting disease process. Historically, patients with AFRS are immunocompetent. The disease is most prevalent in the southeast and south central United States and typically presents with sinus pressure, hyposmia, and congestion. Radiographically, cases of AFRS have a distinct appearance, often exhibiting unilateral heterogeneously dense material, which may erode and expand the paranasal sinus bony walls. Treatment typically consists of surgery, sinonasal irrigations, and topical and systemic steroids, all with the effort to decrease the fungal load and antigenic response. Immunotherapy is also often included in the treatment regimen for AFRS.
authors.affiliation: Applied Medical Research Center, St Vincent’s Hospital and University of New South Wales, and Macquarie University, Darlinghurst, Sydney, New South Wales, Australia.
authors.forename: Adrienne M
authors.initials: AM
authors.lastname: Laury
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Wise
mesh_terms: D002908:Chronic Disease; D003646:Debridement; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D009181:Mycoses / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D012852:Sinusitis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D014057:Tomography, X-Ray Computed; D014481:United States