title: Transient thyrotoxicosis from thyroiditis induced by sibutramine overdose: a case report.
abstract: Sibutramine is an antiobesity drug that inhibits the reuptake of serotonin and noradrenalin in the hypothalamus. A 37-year-old Korean man presented to the emergency room for the oral intake of 280 mg of sibutramine. The patient was in thyrotoxic state. The (99m)Technetium-pertechnetate thyroid scan showed irregular uptake of radioisotope and thyroid-stimulating hormone receptor antibody and thyroperoxidase antibody were negative. Thyroid function normalized after that. The patient had transient thyrotoxicosis with thyroiditis. We report a case of thyrotoxicosis accompanied by thyroiditis resulting from the intentional overdose of sibutramine.
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Gyeongsangnam-do, South Korea.
authors.forename: S K
authors.initials: SK
authors.lastname: Kim
authors.forename: S M
authors.initials: SM
authors.lastname: Lee
authors.forename: S S
authors.initials: SS
authors.lastname: Yoo
authors.forename: J R
authors.initials: JR
authors.lastname: Hahm
authors.forename: J H
authors.initials: JH
authors.lastname: Jung
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: S I
authors.initials: SI
authors.lastname: Chung
authors.forename: T S
authors.initials: TS
authors.lastname: Jung
mesh_terms: D000328:Adult; D019440:Anti-Obesity Agents / Q000633:toxicity*; D003503:Cyclobutanes / Q000633:toxicity*; D062787:Drug Overdose; D006801:Humans; D008297:Male; D013966:Thyroiditis / Q000139:chemically induced*; D013971:Thyrotoxicosis / Q000139:chemically induced*
chemical_list: D019440:Anti-Obesity Agents; D003503:Cyclobutanes; C058254:sibutramine
keywords: Serotonin syndrome; sibutramine; thyroiditis; thyrotoxicosis