title: Filopodia: the cellular quills of hedgehog signaling?
abstract: Reporting in Nature, Sanders et al. (2013) implicate filopodial projections in Sonic hedgehog (Shh) patterning of the limb. Actin-based filopodia transport Shh from producing cells, while filopodia of responding cells bear Cdon and Boc: coreceptors in the Shh pathway. These findings suggest a new mechanism of ligand movement and transmission.
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. amcmahon@med.usc.edu
authors.forename: Andrew P
authors.initials: AP
authors.lastname: McMahon
authors.forename: Sean M
authors.initials: SM
authors.lastname: Hasso
mesh_terms: D000818:Animals; D019521:Body Patterning; D053823:Hedgehog Proteins / Q000378:metabolism*; D011554:Pseudopodia / Q000378:metabolism*
chemical_list: D053823:Hedgehog Proteins