title: Putting a halt on PRC2 in pediatric glioblastoma.
abstract: Two new studies show that the known histone H3 alteration p.Lys27Met in pediatric glioma leads to globally diminished trimethylation at histone H3 lysine 27. The mutant histone H3 acts as a selective inhibitor of the PRC2 chromatin-modifying complex by binding and presumably sequestering it, shedding light on how this variant may contribute to the etiology of these highly malignant brain tumors.
authors.affiliation: Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA.
authors.forename: Philipp
authors.initials: P
authors.lastname: Voigt
authors.forename: Danny
authors.initials: D
authors.lastname: Reinberg
mesh_terms: D005260:Female; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D009154:Mutation
chemical_list: D007521:Isocitrate Dehydrogenase