title: Exploration of macro-micro biomarkers for dampness-heat syndrome differentiation in different diseases.
abstract: Increased attention is being paid to traditional Chinese medicine (TCM) as a complementary and alternative medicine to provide an effective approach for personalized diagnosis and clinical treatment. TMC performs treatment based on differentiation of TCM syndrome (ZHENG), which may identify special phenotypes by symptoms and signs of patients even if they are in different diseases. There has, however, been skepticism and criticism because syndrome classification only depends on observation, knowledge, and clinical experience of TCM practitioners, which lacks objectivity and repeatability. In order to transform syndrome classification into mainstream medicine, we introduce a macro-micro approach that combines symptoms, clinical indicators, and metabolites. The present paper explores the macro-micro biomarkers of dampness-heat syndrome in chronic hepatitis B and nonalcoholic fatty liver patients, which could provide the basis for developing a possible population-screening tool for selecting target individuals and creating an evaluation index for personalized treatment.
authors.affiliation: Center for Traditional Chinese Medicine and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Jianye
authors.initials: J
authors.lastname: Dai
authors.forename: Shujun
authors.initials: S
authors.lastname: Sun
authors.forename: Jinghua
authors.initials: J
authors.lastname: Peng
authors.forename: Huijuan
authors.initials: H
authors.lastname: Cao
authors.forename: Ningning
authors.initials: N
authors.lastname: Zheng
authors.forename: Junwei
authors.initials: J
authors.lastname: Fang
authors.forename: Qianhua
authors.initials: Q
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Jiang
authors.forename: Yongyu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yiyang
authors.initials: Y
authors.lastname: Hu