title: [Role of estradiol in hypoxia-induced pulmonary hypertension in female rats].
abstract: Gender differences play role in pathogenesis and treatment of many cardiovascular diseases. One of these diseases is hypoxia-induced pulmonary hypertension (PHT). The aim of this study was to analyze the involvement of female hormone estradiol in development of hypoxia-induced PHT in female Wistar rats. PHT was induced by exposure to hypobaric hypoxia in an altitude chamber at a simulated altitude of 5000 m (02 concentration reduced to 10 %), 10 h per day for 2 weeks. The development of PHT leads to a twofold increase in the level of estradiol. Ovariectomy decreases by half the level of estradiol and causes significant decrease in hypoxia-induced PHT symptoms.
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Kovaleva
authors.forename: M M
authors.initials: MM
authors.lastname: Artem'eva
authors.forename: M E
authors.initials: ME
authors.lastname: Ilatovskaia
authors.forename: O S
authors.initials: OS
authors.lastname: Medvedev
authors.forename: N A
authors.initials: NA
authors.lastname: Medvedeva
mesh_terms: D000532:Altitude Sickness / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D000818:Animals; D004958:Estradiol / Q000097:blood*; D005260:Female; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D000860:Hypoxia / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors
chemical_list: D004958:Estradiol