title: Local gene transfection in the cochlea (Review).
abstract: There is much interest in the potential application of vector-induced gene therapeutic approaches to several forms of hearing disorders due to the poor efficacy of existing treatments. The cochlea is an ideal site for local gene transfection due to its anatomical encapsulation and fluid flow within its ducts. However, this requires the development of novel technologies in materials science and microbial supply vectors for target gene delivery. This review focuses on the introduction of various viral and non-viral vectors as well as injection approaches to transfecting cochlear cells in vivo. Finally, the perspective of local gene therapy was discussed. Therapeutic approaches using local gene transfection may provide a means of cochlear cell and tissue protection and treatment in cases of exogenous hearing loss and endogenous disorders.
authors.affiliation: Department of Otolaryngology, The Sixth People's Hospital Affiliated to The Shanghai Jiao Tong University, Otolaryngology Institute of The Shanghai Jiao Tong University, Shanghai 200233, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Xia
authors.forename: Shankai
authors.initials: S
authors.lastname: Yin
mesh_terms: D000818:Animals; D003051:Cochlea / Q000378:metabolism*; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006801:Humans; D014162:Transfection