title: Synthesis of an (11) C-labeled antiprion GN8 derivative and evaluation of its brain uptake by positron emission tomography.
abstract: A radiolabeled PET! A (11) C-labeled derivative of N,N'-(methylenedi-4,1-phenylene)bis[2-(1-pyrrolidinyl) acetamide] (GN8), an antiprion agent currently under development, was synthesized by palladium-catalyzed rapid methylation of aryltributylstannane and assessed for brain penetration and organ distribution in rats by positron emission tomography (PET).
authors.affiliation: Center for Emerging Infectious Diseases, United Graduate School of Drug Discovery & Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kimura
authors.forename: Takeo
authors.initials: T
authors.lastname: Sako
authors.lastname: Siqin
authors.forename: Junji
authors.initials: J
authors.lastname: Hosokawa-Muto
authors.forename: Yi Long
authors.initials: YL
authors.lastname: Cui
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Wada
authors.forename: Yosky
authors.initials: Y
authors.lastname: Kataoka
authors.forename: Hisashi
authors.initials: H
authors.lastname: Doi
authors.forename: Suehiro
authors.initials: S
authors.lastname: Sakaguchi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Suzuki
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kuwata
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D002250:Carbon Radioisotopes; D006801:Humans; D015394:Molecular Structure; D049268:Positron-Emission Tomography; D011328:Prions / Q000037:antagonists & inhibitors*; D014018:Tissue Distribution
chemical_list: D000081:Acetamides; D002250:Carbon Radioisotopes; D011328:Prions