title: Subclinical diastolic dysfunction in children with Wilson's disease assessed by tissue Doppler echocardiography: a possible early predictor of cardiac involvement.
abstract: BACKGROUND
  The aim of this study was to evaluate the left ventricular systolic and diastolic functions and cardiac rhythm problems for the early detection of myocardial dysfunction in children with Wilson's disease.
  
  
  METHODS
  We compared patients who had Wilson's disease (n = 22) witl Wilson's disease was based on clinical symptoms and laboratory tests (serum ce cardiographic examination, as well as pulsed-wave Doppler, tissue Doppler ech Holter monitoring was also performed in all subjects.
  
  
  RESULTS
  All patients were asymptomatic on cardiological examination an tion, fractional shortening, wall thickness and left ventricular mass were similar disease had significantly lower mitral E velocity, mitral E/A ratio (P= 0.046, P= 0.0 as estimated by pulsed wave Doppler echocardiography. Wilson patients had lo pler echocardiography (P=0.006) compared to the controls. On 24-hour ECG cardiac arrhythmia.
  
  
  CONCLUSIONS
  Our study showed results that might be consistent with disease children which probably represents an early stage of cardiac involvem the patients.
authors.affiliation: Department of Pediatric Cardiology, Inonu University Faculty of Medicine, Malatya, Turkey. ozlemelkiran@yahoo.com
authors.forename: Ozlem
authors.initials: O
authors.lastname: Elkiran
authors.forename: Cemsit
authors.initials: C
authors.lastname: Karakurt
authors.forename: Ayse
authors.initials: A
authors.lastname: Selimoglu
authors.forename: Hamza
authors.initials: H
authors.lastname: Karabiber
authors.forename: Gulendam
authors.initials: G
authors.lastname: Kocak
authors.forename: Serkan F
authors.initials: SF
authors.lastname: Celik
authors.forename: Cemil
authors.initials: C
authors.lastname: Colak
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003971:Diastole / Q000502:physiology; D018619:Echocardiography, Doppler, Pulsed; D054459:Elasticity Imaging Techniques; D005260:Female; D006527:Hepatolenticular Degeneration / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000000981:diagnostic imaging*