title: Interleukin 1B rs16944 G>A polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population.
abstract: OBJECTIVE
  Esophageal cancer is the sixth leading cause of cancer-associated deaths worldwide and represents a particularly aggressive type of cancer. Genetic polymorphisms may partly explain individual differences in esophageal cancer susceptibility.
  
  
  METHODS
  We conducted a hospital-based case-control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs) in the interleukin 1 (IL1A and IL1B), IL1f7, IL3 and IL7Ra genes on the development of esophageal cancer. A total of 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for this study. The genotypes were determined using a custom-by-design 48-Plex SNPscan™ Kit.
  
  
  RESULTS
  When the IL1B rs16944 GG homozygote genotype was used as the reference group, the GA genotype was associated with a significantly decreased risk of ESCC (GA vs. GG: adjusted OR=0.69, 95% CI=0.49-0.99, p=0.041). However, there were no significant associations between the other five SNPs and ESCC risk. Stratified analyses indicated no significantly different risks of ESCC associated with the IL1B rs16944 G>A polymorphism according to sex, age, smoking status or alcohol consumption. IL3 rs2073506 G>A polymorphism was associated with an increased risk for ESCC higher tumor, nodal, and metastatic (TNM) stages.
  
  
  CONCLUSIONS
  These findings indicated that the functional IL1B rs16944 G>A polymorphism might contribute to ESCC susceptibility. IL3 rs2073506 G>A polymorphism was associated with an increased risk for ESCC higher TNM stages. However, the results were based on a limited sample size and larger well-designed studies are warranted to confirm these initial findings.
authors.affiliation: Department of Cardiothoracic Surgery, The First People's Hospital of Changzhou and The Third Affiliated Hospital of Suzhou University, Changzhou 213003, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zheng
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.forename: Liming
authors.initials: L
authors.lastname: Wang
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Yijun
authors.initials: Y
authors.lastname: Shi
authors.forename: Aizhong
authors.initials: A
authors.lastname: Shao
authors.forename: Weifeng
authors.initials: W
authors.lastname: Tang
authors.forename: Guowen
authors.initials: G
authors.lastname: Ding
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Suocheng
authors.initials: S
authors.lastname: Chen
authors.forename: Haiyong
authors.initials: H
authors.lastname: Gu
mesh_terms: D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking; D044466:Asian People; D002294:Carcinoma, Squamous Cell / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000235:genetics*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006720:Homozygote; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D007377:Interleukin-3 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012737:Sex Factors; D012907:Smoking
chemical_list: C508596:IL3 protein, human; D053583:Interleukin-1beta; D007377:Interleukin-3
keywords: CI; Esophageal cancer; IL1B; LD; Molecular epidemiology; OR; Polymorphisms; SNPs; confidential interval; interleukin 1 beta; linkage disequilibrium; odds ratio; single nucleotide polymorphisms