title: Urinary exosome miRNome analysis and its applications to salt sensitivity of blood pressure.
abstract: OBJECTIVE
  To investigate microRNAs (miRNAs) in urinary exosomes and their association with an individual's blood pressure response to dietary salt intake.
  
  
  METHODS
  Human urinary exosomal miRNome was examined by microarray.
  
  
  RESULTS
  Of 1898 probes tested, 194 miRNAs were found in all subjects tested. 45 miRNAs had significant associations with salt sensitivity or inverse salt sensitivity.
  
  
  CONCLUSIONS
  The expression of 45 urinary exosomal miRNAs associates with an individual's blood pressure response to sodium.
authors.affiliation: Department of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Gildea
authors.affiliation: Department of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA.
authors.forename: Julia M
authors.initials: JM
authors.lastname: Carlson
authors.affiliation: Department of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA; Department of Internal Medicine, The University of Virginia Health System, Charlottesville, VA 22908, USA.
authors.forename: Cynthia D
authors.initials: CD
authors.lastname: Schoeffel
authors.affiliation: Department of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA; Department of Internal Medicine, The University of Virginia Health System, Charlottesville, VA 22908, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Carey
authors.affiliation: Department of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA. Electronic address: raf7k@virginia.edu.
authors.forename: Robin A
authors.initials: RA
authors.lastname: Felder
mesh_terms: D001794:Blood Pressure / Q000187:drug effects* / Q000235:genetics*; D055354:Exosomes / Q000378:metabolism*; D020869:Gene Expression Profiling; D006801:Humans; D035683:MicroRNAs / Q000652:urine*; D017673:Sodium Chloride, Dietary / Q000494:pharmacology*
chemical_list: D035683:MicroRNAs; D017673:Sodium Chloride, Dietary
keywords: BP; Blood pressure; Exosome; ISS; MAP; SR; SS; Salt-resistant; Salt-sensitive; blood pressure; inverse salt-sensitive; mean arterial pressure; miRNA; salt-resistant; salt-sensitive