title: Safety assessment of silylates and surface-modified siloxysilicates.
abstract: The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate as used in cosmetics. These silylates and surface-modified siloxysilicates function in cosmetics as antifoaming agents, anticaking agents, bulking agents, binders, skin-conditioning agents--emollient, skin-conditioning agents-occlusive, slip modifiers, suspension agents--nonsurfactant, and viscosity increasing agents--nonaqueous. The Expert Panel reviewed the available animal and clinical data as well as information from a previous CIR safety assessment of amorphous silica. The CIR Expert Panel concluded that silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate are safe as used when formulated and delivered in the final product not to be irritating or sensitizing to the respiratory tract.
authors.affiliation: Cosmetic Ingredient Review, 1101 17th Street, NW, Suite 412, Washington, DC 20036, USA.
authors.forename: Lillian C
authors.initials: LC
authors.lastname: Becker
authors.forename: Wilma F
authors.initials: WF
authors.lastname: Bergfeld
authors.forename: Donald V
authors.initials: DV
authors.lastname: Belsito
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Hill
authors.forename: Curtis D
authors.initials: CD
authors.lastname: Klaassen
authors.forename: Daniel
authors.initials: D
authors.lastname: Liebler
authors.forename: James G
authors.initials: JG
authors.lastname: Marks
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Shank
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Slaga
authors.forename: Paul W
authors.initials: PW
authors.lastname: Snyder
authors.forename: F Alan
authors.initials: FA
authors.lastname: Andersen
mesh_terms: D000818:Animals; D003257:Consumer Product Safety; D003358:Cosmetics / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D012827:Silicone Oils / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D013499:Surface Properties; D018675:Toxicity Tests / Q000379:methods; D014297:Trimethylsilyl Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: C509130:Antifoam A; D003358:Cosmetics; D006845:Hydrocarbons, Fluorinated; D017646:Organosilicon Compounds; D012827:Silicone Oils; D014297:Trimethylsilyl Compounds; D012822:Silicon Dioxide
keywords: silylates