title: A newly designed anal fistula plug: clinicopathological study in an experimental iatrogenic fistula model.
abstract: We report on a clinicopathologic study in an animal model of treatment with a new bioabsorbable polymer plug (BAPP). Over a 2-week period, 6 porcine models, which each had 4 anal fistulae, were created using Blake drains. The pigs were divided into 2 groups: the BAPP-treatment group (n = 12 fistulae) and the control group (n = 12 fistulae). Two weeks later, the pigs were humanely killed, and the perianal sites were excised and examined with gross and pathologic studies. Each fistula in the BAPP group was completely cured. In the pathologic study, the treatment sites had little disarray, few defects in the muscular layer, and small numbers of inflammatory cells. The control group had a significantly greater number of inflammatory cells and microabscesses than the BAPP group. The newly developed BAPP reduced the infection and induced good healing in anal fistulae. The BAPP may be a useful new device for the clinical treatment of anal fistulae.
authors.affiliation: 1 Department of Surgery, Gastrointestinal Center, Saitama Medical University, International Medical Center, Saitama, Japan.
authors.forename: Masayasu
authors.initials: M
authors.lastname: Aikawa
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Miyazawa
authors.forename: Katsuya
authors.initials: K
authors.lastname: Okada
authors.forename: Naoe
authors.initials: N
authors.lastname: Akimoto
authors.forename: Isamu
authors.initials: I
authors.lastname: Koyama
authors.forename: Shigeki
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Ikada
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D004195:Disease Models, Animal; D019344:Lactic Acid; D011091:Polyesters; D011108:Polymers; D012003:Rectal Fistula / Q000628:therapy*; D013552:Swine; D013630:Tampons, Surgical; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; D019344:Lactic Acid; C033616:poly(lactide)