title: [Effect of homocysteine on left ventricular structural and functional parameters in patients on programmed hemodialysis].
abstract: OBJECTIVE
  To determine the effect of plasma homocysteine (Hc) on the structure and function of the left ventricle (LV) in patients treated by programmed hemodialysis.
  
  
  METHODS
  109 patients on programmed hemodialysis were examined. Blood Hc levels were determined and echocardiography was performed in all the patients.
  
  
  RESULTS
  In the patients on programmed hemodialysis, Hc concentrations were significantly higher than in apparently healthy individuals; there was a preponderance of mild (49.5%) and moderate (43.1%) hyperhomocysteinemia. LV hypertrophy was diagnosed in 90.8% of the patients. A positive relationship was found between the concentrations of Hc and the E/A ratio (r = 0.34; p = 0.05), isovolumetric relaxation time (IRT) (r = 0.32; p = 0.03), and LV mass (LVM) (r = 0.3; p = 0.05). Multivariate regression analysis indicated that the level of Hc had an independent impact on the E peak (R2 = 0.3; p = 0.05), LV relative wall thickness (RWT) (R2 = 0.38; p = 0.03), and LV IRT (R2 = 0.3; p = 0.06).
  
  
  CONCLUSIONS
  Elevated plasma Hc levels were found to be related to LVM, LV RWT, LV IRT, E peak, and E/A ratio, suggesting that Hc had an unfavorable effect on the LV structure and function in patients on hemodialysis.
authors.forename: U V
authors.initials: UV
authors.lastname: Kharlamova
authors.forename: O E
authors.initials: OE
authors.lastname: Il'icheva
mesh_terms: D000328:Adult; D005260:Female; D006352:Heart Ventricles / Q000737:chemistry / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006710:Homocysteine / Q000097:blood / Q000502:physiology*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D013329:Structure-Activity Relationship; D014463:Ultrasonography; D020257:Ventricular Remodeling / Q000502:physiology
chemical_list: D006710:Homocysteine