title: The role of HMGB1 in inflammation-mediated organ injury.
abstract: HMGB1 is a chromosome-binding protein that also acts as a damage-associated molecular pattern molecule. It has potent proinflammatory effects and is one of key mediators of organ injury. Evidence from research has revealed its involvement in the signaling mechanisms of Toll-like receptors and the receptor for advanced glycation end-products in organ injury. HMGB1-mediated organ injuries are acute damage including ischemic, mechanical, allograft rejection and toxicity, and chronic diseases of the heart, kidneys, lungs, and brain. Strategies against HMGB1 and its associated cellular signal pathways need to be developed and may have preventive and therapeutic potentials in organ injury.
authors.affiliation: Section of Anaesthetics, Pain Medicine & Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, UK.
authors.forename: Paladd
authors.initials: P
authors.lastname: Asavarut
authors.forename: Hailin
authors.initials: H
authors.lastname: Zhao
authors.forename: Jianteng
authors.initials: J
authors.lastname: Gu
authors.forename: Daqing
authors.initials: D
authors.lastname: Ma
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology; D009202:Cardiomyopathies / Q000209:etiology; D017127:Glycation End Products, Advanced / Q000502:physiology; D006084:Graft Rejection / Q000209:etiology; D024243:HMGB1 Protein / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D019636:Neurodegenerative Diseases / Q000209:etiology; D015427:Reperfusion Injury / Q000209:etiology*; D013314:Stress, Mechanical; D051197:Toll-Like Receptor 4 / Q000502:physiology
chemical_list: D017127:Glycation End Products, Advanced; D024243:HMGB1 Protein; D051197:Toll-Like Receptor 4