title: Anxiolytic potential of ursolic acid derivative--a stearoyl glucoside isolated from Lantana camara L. (Verbanaceae).
abstract: OBJECTIVE
  To investigate the anxiolytic activity of newly isolated compound by our lab called ursolic acid stearoyl glucoside (UASG) from the leaves of Lantana camara (L. camara).
  
  
  METHODS
  Column chromatography was used to isolate UASG. Anxiolytic potential was experimentally proved and demonstrated through Elevated plus-maze, Open field and light and dark test.
  
  
  RESULTS
  The UASG showed marked increased in time spent (%) and number of frequent movements made by animals in open arm of elevated plus-maze apparatus. In light and dark model, UASG produced marked increase in time spent by animal, number of crossing and reduced duration of immobility in light box.
  
  
  CONCLUSIONS
  UASG showed significant increase in number of rearing, assisted rearing and number of square crossed in open field established test model. UASG showed its anxiolytic effect in dose dependent manner.
authors.affiliation: Siddhartha Institute of Pharmacy, Dehra Dun, Uttarakhand, India.
authors.forename: Imran
authors.initials: I
authors.lastname: Kazmi
authors.forename: Muhammad
authors.initials: M
authors.lastname: Afzal
authors.forename: Babar
authors.initials: B
authors.lastname: Ali
authors.forename: Zoheir A
authors.initials: ZA
authors.lastname: Damanhouri
authors.forename: Aftab
authors.initials: A
authors.lastname: Ahmaol
authors.forename: Firoz
authors.initials: F
authors.lastname: Anwar
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D032410:Lantana / Q000737:chemistry*; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; D010936:Plant Extracts; D012503:Saponins; C578190:urs-12-en-3-ol-28-oic acid 3-glucopyranosyl-4'-octadecanoate