title: Tracheal wall thickening is associated with the granulation tissue formation around silicone stents in patients with post-tuberculosis tracheal stenosis.
abstract: OBJECTIVE
  Tracheal restenosis due to excessive granulation tissue around a silicone stent requires repeated bronchoscopic interventions in patients with post-tuberculosis tracheal stenosis (PTTS). The current study was conducted to identify the risk factors for granulation tissue formation after silicone stenting in PTTS patients.
  
  
  METHODS
  A retrospective study was conducted between January 1998 and December 2010. Forty-two PTTS patients with silicone stenting were selected. Clinical and radiological variables were retrospectively collected and analyzed.
  
  
  RESULTS
  Tracheal restenosis due to granulation tissue formation were found in 20 patients (47.6%), and repeated bronchoscopic interventions were conducted. In multivariate analysis, tracheal wall thickness, measured on axial computed tomography scan, was independently associated with granulation tissue formation after silicone stenting. Furthermore, the degree of tracheal wall thickness was well correlated with the degree of granulation tissue formation.
  
  
  CONCLUSIONS
  Tracheal wall thickening was associated with granulation tissue formation around silicone stents in patients with post-tuberculosis tracheal stenosis.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea.
authors.forename: Jung Seop
authors.initials: JS
authors.lastname: Eom
authors.forename: Hojoong
authors.initials: H
authors.lastname: Kim
authors.forename: Kyeongman
authors.initials: K
authors.lastname: Jeon
authors.forename: Sang-Won
authors.initials: SW
authors.lastname: Um
authors.forename: Won-Jung
authors.initials: WJ
authors.lastname: Koh
authors.forename: Gee Young
authors.initials: GY
authors.lastname: Suh
authors.forename: Man Pyo
authors.initials: MP
authors.lastname: Chung
authors.forename: O Jung
authors.initials: OJ
authors.lastname: Kwon
mesh_terms: D000328:Adult; D001999:Bronchoscopy / Q000379:methods; D005260:Female; D006097:Granulation Tissue / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012828:Silicones; D015607:Stents / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D014132:Trachea / Q000473:pathology*; D014135:Tracheal Stenosis / Q000209:etiology / Q000473:pathology*; D014376:Tuberculosis / Q000150:complications*
chemical_list: D012828:Silicones
keywords: Trachea; bronchoscopy; intervention; stenosis; stents; tuberculosis