title: ALDH2 rs671 Polymorphism and coronary heart disease risk among Asian populations: a meta-analysis and meta-regression.
abstract: Mitochondrial aldehyde dehydrogenase-2 (ALDH2) is the principal enzyme involved in alcohol metabolism in humans. Emerging evidence has shown that the common rs671 G>A (Glu504Lys) polymorphism in the ALDH2 gene might play a critical role in increasing the susceptibility to coronary heart disease (CHD), including myocardial infarction (MI); however, individually published studies showed inconclusive results. This meta-analysis aimed to derive a more precise estimation of the relationship between the ALDH2 rs671 polymorphism and its influence on the susceptibility to CHD and MI. Nine case-control studies were included with a total of 7358 subjects, including 1961 CHD patients, 1040 MI patients, and 4357 healthy controls. Our meta-analysis results showed that the A variant of the ALDH2 rs671 polymorphism may be associated with increase risks of CHD (odds ratios [OR]=1.36, 95% confidence interval [CI]=1.06-1.75, p=0.017) and MI (OR=1.64, 95% CI=1.22-2.20, p=0.001). Univariate and multivariate meta-regression analyses showed no potential factors explained heterogeneity. No publication bias was detected in this meta-analysis. In conclusion, the current meta-analysis indicates that the A variant of the ALDH2 rs671 polymorphism may increase the risk of both CHD and MI among Asian populations.
authors.affiliation: Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Shaobo
authors.initials: S
authors.lastname: Zhou
authors.forename: Lijie
authors.initials: L
authors.lastname: Wang
authors.forename: Mingming
authors.initials: M
authors.lastname: Lei
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Chi
authors.initials: C
authors.lastname: Miao
authors.forename: Yuanzhe
authors.initials: Y
authors.lastname: Jin
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D044466:Asian People / Q000235:genetics*; D003327:Coronary Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial