title: Reconstruction of total upper eyelid with prefabricated capsule-lined advancement flaps.
abstract: BACKGROUND
  A total upper eyelid defect is a rare problem that may result from tumor excision, trauma, or burns. Reconstruction of a total upper eyelid defect involves the reconstruction of 2 fundamental elements: anterior and posterior lamellae. Because an expander capsule looks like the palpebral conjunctiva with a moist, smooth, white glistening appearance, its use was investigated in the repair of total upper eyelid defects in rabbits.
  
  
  METHODS
  Sixty-six tissue expanders with the autogeneic conchal chondro-grafts were implanted into the foreheads of 66 rabbits. After 6 to 8 weeks, the sandwich-prefabricated advancement flaps were designed to reconstruct rectangular excisions of the upper eyelid. The cartilage was preliminarily inserted in a flap, formed by tissue expansion, and then transferred to an upper eyelid defect in the rabbit. Histopathology was evaluated at 3 days, 1 week, 2 weeks, 1 month, 2 months, and 4 months after reconstruction. The upper palpebral length was measured after 4 months of reconstruction as a 1-dimension reference point of flap contracture.
  
  
  RESULTS
  No edema, congestion, infection, corneal damage, or necrosis were observed during the reconstructions. Histopathologic studies revealed that the long-term capsule had a normal conjunctiva-like appearance with a stratified columnar epithelium. The average shortening, measured as the length between inner to outer canthal folds, was inconspicuous.
  
  
  CONCLUSIONS
  The expander capsule has the potential to act as an effective posterior lamellar substitute of eyelid in a rabbit model. Further studies should be undertaken to see if this represents a good model for a potential human clinical application.
authors.affiliation: Plastic Surgery Hospital, Chinese Academy Of Medical Sciences, Peking Union Medical College, Beijing, China.
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Gu
authors.forename: Xin
authors.initials: X
authors.lastname: Guo
authors.forename: Tailing
authors.initials: T
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Yu
authors.forename: Wenshuang
authors.initials: W
authors.lastname: Yang
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D064592:Autografts / Q000637:transplantation; D019882:Blepharoplasty / Q000379:methods*; D003228:Conjunctiva / Q000473:pathology / Q000601:surgery; D003286:Contracture / Q000473:pathology; D003315:Cornea / Q000473:pathology; D004425:Ear Cartilage / Q000637:transplantation; D005141:Eyelid Diseases / Q000601:surgery; D005143:Eyelids / Q000473:pathology / Q000601:surgery*; D005240:Feasibility Studies; D005546:Forehead / Q000601:surgery; D023421:Models, Animal; D011183:Postoperative Complications; D011817:Rabbits; D016038:Skin Transplantation / Q000379:methods; D013524:Surgical Flaps / Q000601:surgery*; D013997:Time Factors; D015626:Tissue Expansion / Q000379:methods; D015625:Tissue Expansion Devices / Q000145:classification*; D014945:Wound Healing / Q000502:physiology