title: Electric field induced DNA damage: an open door for selective mutations.
abstract: Intense electric fields activate the mutagenic mechanism of a single guanine-cytosine base pair. Would they be able to induce a permanent mutation in real DNA? This question is addressed here by modeling a DNA-embedded fragment with state-of-the-art theoretical tools. We show how DNA can, in principle, be mutated if an appropriate electric field is applied.
authors.affiliation: CEISAM, UMR CNRS 6230, BP 92208, Université de Nantes, 2, Rue de la Houssinière, 44322 Nantes Cedex 3, France. Jose.Ceron@univ-nantes.fr
authors.forename: José Pedro
authors.initials: JP
authors.lastname: Cerón-Carrasco
authors.forename: Denis
authors.initials: D
authors.lastname: Jacquemin
mesh_terms: D020029:Base Pairing; D003596:Cytosine / Q000737:chemistry; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004249:DNA Damage; D004560:Electricity; D006147:Guanine / Q000737:chemistry; D009154:Mutation; D013816:Thermodynamics
chemical_list: D006147:Guanine; D003596:Cytosine; D004247:DNA