title: An excess of prior irritable bowel syndrome diagnoses or treatments in Celiac disease: evidence of diagnostic delay.
abstract: OBJECTIVE
  It is recognized that celiac disease can present with symptoms characteristic of irritable bowel syndrome (IBS) and that a substantial proportion of patients referred to gastroenterologists with these symptoms may have celiac disease. The authors set out to discover how commonly those suffering with celiac disease are misdiagnosed as suffering from IBS and whether such misdiagnosis delays the correct diagnosis.
  
  
  METHODS
  A case control study using computerized records from the General Practice Research Database was conducted. The authors compared the proportion of patients with celiac disease who had a diagnosis of or had undergone treatment for IBS over a variety of time periods before the diagnosis of celiac disease with the proportion of a matched group without celiac disease who were similarly diagnosed or treated.
  
  
  RESULTS
  It was found that 16% of celiac patients had such a prior diagnosis compared to 4.9% of controls (a threefold increased risk of prior IBS; OR = 3.8, 95% CI: 3.6-4.2), and that if one looked at typical treatment for IBS rather than diagnostic codes, 28% of celiac patients appeared to have been treated compared to 9% of controls. Many of the diagnoses of IBS occurred within the last year before diagnosis of celiac disease, but there was a clear excess of IBS even 10 years earlier.
  
  
  CONCLUSIONS
  In contemporary UK practice, it is likely that at least some patients with celiac disease spend many years being treated as having IBS. Following guidelines to test serologically for celiac disease will minimize this problem.
authors.affiliation: Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building Phase 2, Nottingham City Hospital, Nottingham, UK. tim.card@nottingham.ac.uk
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Card
authors.forename: Jesse
authors.initials: J
authors.lastname: Siffledeen
authors.forename: Joe
authors.initials: J
authors.lastname: West
authors.forename: Kate M
authors.initials: KM
authors.lastname: Fleming
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002446:Celiac Disease / Q000175:diagnosis*; D016208:Databases, Factual; D057210:Delayed Diagnosis / Q000706:statistics & numerical data*; D003951:Diagnostic Errors / Q000706:statistics & numerical data*; D005260:Female; D058006:General Practice; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D006113:United Kingdom; D055815:Young Adult