title: Chemical constituents of the stems of Celastrus rugosus.
abstract: Two new sesquiterpene pyridine alkaloids rugosusines A and B (1 and 2), and thirty-one known compounds were isolated from the stems of Celastrus rugosus. The structures of new compounds were elucidated by detailed spectroscopic analysis, including HR-ESI-MS and 2D NMR spectroscopic data. All the compounds were isolated from this plant for the first time. The cytotoxicities of these compounds were tested against SKOV3 and MGC-803 cell lines by CCK-8 method.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
authors.forename: Ruijie
authors.initials: R
authors.lastname: Chang
authors.forename: Chunhui
authors.initials: C
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zeng
authors.forename: Bin
authors.initials: B
authors.lastname: Guan
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhang
authors.forename: Huizi
authors.initials: H
authors.lastname: Jin
mesh_terms: D000470:Alkaloids / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031247:Celastrus / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry*; D011725:Pyridines / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D011725:Pyridines; D012717:Sesquiterpenes