title: [Remote signaling of radiation damage to the extracellular space in mice with various levels of genetically determined radio sensitivity].
abstract: The search results of "bystander" signals are presented at different model of influence of IR on Balb/c and C57bl/6 mice, characterized by different levels of genetically determined sensitivity to IR influence. We used the following models of IR influence: 1) external gamma-quanta influence from small samples of nuclear fuel from the CNPP 4th power unit modified in the course of the accident in 1986, which are 99% connected with 137Cs, with the total dose of irradiation of about 5.0 Gy for 16 hours and accumulated dose of 0.290 Gy for 231 day of exposure, 2) internal intake of 137Cs with water for 40 days. It is shown that cells of different types (splenocytes, hepatocytes, bone marrow and astroglia cells) irrespective of a model of IR influence produce the factors, which failed to be identified in this research, raising the SSF levels in the DNA of non-irradiated cells. Under conditions of a single exposure to gamma-field external irradiation at a dose of about 5.0 Gy, the intensity of production of "bystander" signals is higher in the mice with the raised level of genetically determined sensitivity to RI (Balb/c). Under the same conditions of gamma-field exposure, induction of additional levels of SSF in the DNA of non-irradiated cells is detected for at least one month after IR exposure. Intraperitoneal injection of melanin in the melanin-glucan complex from fungus F. fomentarius before irradiation exposure promotes an essential decrease in the production of "bystander" signals, testifying in favor of the free radical nature of their certain part.
authors.forename: O F
authors.initials: OF
authors.lastname: Senuk
authors.forename: V A
authors.initials: VA
authors.lastname: Kovalev
authors.forename: N I
authors.initials: NI
authors.lastname: Krul'
authors.forename: A V
authors.initials: AV
authors.lastname: Zhidkov
authors.forename: G F
authors.initials: GF
authors.lastname: Chemerskiĭ
authors.forename: S S
authors.initials: SS
authors.lastname: Kireev
authors.forename: L F
authors.initials: LF
authors.lastname: Gorovoĭ
authors.forename: T
authors.initials: T
authors.lastname: Gergeĭ
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D001773:Blood Cells / Q000187:drug effects / Q000528:radiation effects; D024201:Bystander Effect / Q000235:genetics*; D002588:Cesium Radioisotopes / Q000633:toxicity; D047852:Chernobyl Nuclear Accident; D004247:DNA / Q000528:radiation effects*; D005110:Extracellular Space / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D008543:Melanins / Q000008:administration & dosage; D051379:Mice; D009154:Mutation / Q000528:radiation effects; D011836:Radiation Tolerance / Q000235:genetics / Q000502:physiology / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D014455:Ukraine; D014916:Whole-Body Irradiation
chemical_list: D002588:Cesium Radioisotopes; D008543:Melanins; D011837:Radiation-Protective Agents; D004247:DNA