title: Value of pharmacy-based influenza surveillance - Ontario, Canada, 2009.
abstract: As part of ongoing efforts by the Public Health Agency of Canada (PHAC) to enhance disease surveillance, a retrospective epidemiologic study was undertaken to investigate the usefulness for influenza surveillance of data on changes in the volume of prescriptions for antiviral medications. The weekly numbers of dispensed prescriptions for the antiviral medications oseltamivir and zanamivir, as a proportion of all dispensed prescriptions, were compared with the numbers of confirmed laboratory reports of influenza A(H1N1) at the local health authority level in Ontario, Canada, during the second wave of the outbreak of pandemic influenza A(H1N1) in 2009. Qualitative and quantitative analyses demonstrated that antiviral prescription dispensing dates were a reasonable proxy for influenza A(H1N1) onset dates at the local health authority level. This report describes the results of those analyses, which indicated that 1) antiviral prescription proportions increased in advance of laboratory reports of influenza and 2) antiviral dispensing data can be available in near real-time. These findings suggest that pharmacy prescription data can provide timely intelligence to help characterize local influenza activity.
mesh_terms: D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000188:drug therapy* / Q000453:epidemiology*; D008297:Male; D009864:Ontario / Q000453:epidemiology; D053139:Oseltamivir / Q000627:therapeutic use; D011159:Population Surveillance / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult; D053243:Zanamivir / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir; D053243:Zanamivir