title: Studies on antibacterial mechanisms of copper complexes with 1,10-phenanthroline and amino acid on Escherichia coli.
abstract: The antibacterial mechanisms of Cu(phen)2Cl2·6H2O, [Cu(phen)(Gly)(H2O)]Cl·3H2O, [Cu(phen)(L-Ser)(H2O)Cl] (1,10-phenanthroline (phen)) on Escherichia coli were investigated. In the inductively coupled plasma atomic emission spectroscopy experiments, it showed that lipophilic phen ligand can cause elevation of intracellular copper, but intracellular copper is not the decisive factor. The UV-vis and gel electrophoresis experiments reveal that the DNA binding and cleavage activity are decisive factors for the antibacterial action of these compounds. It is revealed by the cyclic voltammetry experiments that the redox potential was bound to the cleave activity.
authors.affiliation: Department of Chemistry, School of Science, Wuhan University of Technology, Wuhan 430070, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Xi
authors.initials: X
authors.lastname: Li
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yulin
authors.initials: Y
authors.lastname: Dong
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Chaocan
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D053837:DNA Cleavage / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects*; D010618:Phenanthrolines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D010618:Phenanthrolines; D003300:Copper; C025205:1,10-phenanthroline