title: Three-component assembly of structurally diverse 2-aminopyrimidine-5-carbonitriles.
abstract: An expedient route for the synthesis of libraries of diversely decorated 2-aminopyrimidine-5-carbonitriles is reported. This approach is based on a three-component reaction followed by spontaneous aromatization.
authors.affiliation: Center for Research in Biological Chemistry and Molecular Materials (CIQUS) and ‡Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela , Santiago de Compostela, 15782, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Val
authors.forename: Abel
authors.initials: A
authors.lastname: Crespo
authors.forename: Vicente
authors.initials: V
authors.lastname: Yaziji
authors.forename: Alberto
authors.initials: A
authors.lastname: Coelho
authors.forename: Jhonny
authors.initials: J
authors.lastname: Azuaje
authors.forename: Abdelaziz
authors.initials: A
authors.lastname: El Maatougui
authors.forename: Carlos
authors.initials: C
authors.lastname: Carbajales
authors.forename: Eddy
authors.initials: E
authors.lastname: Sotelo
mesh_terms: D020650:Combinatorial Chemistry Techniques; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009570:Nitriles; D011743:Pyrimidines; D054852:Small Molecule Libraries; C012180:2-aminopyrimidine