title: Disseminated intravascular coagulation.
abstract: Disseminated intravascular coagulation (DIC) is a serious, life-threatening condition in humans and animals.A secondary complication in a variety of disorders, it is a complex syndrome in which excessive intravascular coagulation leads to microthromboses in and consequential failure of multiple organs with concurrent paradoxical bleeding due to inactivation and excessive consumption of platelets and clotting factors. This article discusses the pathophysiology, diagnosis, and treatment of DIC in dogs and cats. Novel treatments and laboratory tests, some of which are still being experimentally evaluated, are also discussed.
authors.affiliation: The Hebrew University of Jerusalem, Israel.
authors.forename: Yaron
authors.initials: Y
authors.lastname: Bruchim
authors.forename: Itamar
authors.initials: I
authors.lastname: Aroch
authors.forename: Joseph
authors.initials: J
authors.lastname: Saragusty
authors.forename: Trevor
authors.initials: T
authors.lastname: Waner
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000097:blood / Q000627:therapeutic use*; D000933:Antifibrinolytic Agents / Q000097:blood / Q000627:therapeutic use; D002371:Cat Diseases / Q000175:diagnosis* / Q000628:therapy; D002415:Cats; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000628:therapy; D004285:Dogs; D004730:Endothelium, Vascular / Q000502:physiology; D005342:Fibrinolysis / Q000502:physiology; D006403:Hematologic Tests / Q000662:veterinary; D006487:Hemostasis / Q000502:physiology*; D013917:Thrombin / Q000502:physiology / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D000933:Antifibrinolytic Agents; D013917:Thrombin