title: Rectum sarcoma: challenging diagnostic and therapeutic modalities.
abstract: BACKGROUND
  Sarcomas are malignant tumors that arise from mesenchymal tissue at any of the body sites. They incorporate the wide category of GISTs and are classified in various histological types. Histological grading is another indicator of the degree of malignancy, the probability of distant metastases, and survival but remains a poor definition of local recurrence.
  
  
  CONCLUSIONS
  The size and depth of invasion are the most important prognostic factors. Since they grow within the intestinal wall, the symptoms are usually few or late, leading to delays in diagnosis. Most common signs are rectal bleeding, abdominal or anal pain, diarrhea, tenesmus and weight loss. The diagnostic and staging protocol of stromal tumors of the rectum includes mainly endoscopic surveillance, computed tomography, and magnetic resonance imaging. Therefore, rectum sarcoma (RS) consists one of the most biologically virulent cancers and is difficult to cure by conventional procedures. The treatment is primarily surgical, where possible, and should guarantee complete clearance of the tumor, which often requires an aggressive approach. Unfortunately, the minority of patients is eligible to undergo surgical intervention. In addition, surgical removal of RS does not necessarily indicate a patient's long-term recovery. Alternative therapies, such as radio- and chemotherapy, proved insufficient. Elucidation of its molecular basis may prove useful in developing and identifying prognostic biomarkers.
authors.affiliation: 4th Department of Surgery, Medical School, Athens University, Attikon University Hospital, 1 Rimini str., 12462, Chaidari, Athens, Greece. dr_kamast@yahoo.gr
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Mastoraki
authors.forename: Dionysios
authors.initials: D
authors.lastname: Psarras
authors.forename: Sotiria
authors.initials: S
authors.lastname: Mastoraki
authors.forename: Pantelis
authors.initials: P
authors.lastname: Vassiliu
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Danias
authors.forename: Vasilios
authors.initials: V
authors.lastname: Smyrniotis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Arkadopoulos
mesh_terms: D006801:Humans; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D012509:Sarcoma / Q000175:diagnosis* / Q000628:therapy*