title: [Lethal effects of scopoletin and bisdemethoxycurcumin against Tetranychus cinnabarinus Boisd. (Acari: Tetranychidae): a simulation study].
abstract: By using slide-dip bioassay method under laboratory condition, an investigation was made on the lethal effects of scopoletin, bisdemethoxycurcumin (BDMC), and their combination at an optimal mass ratio (7:6) of scopoletin to BDMC against the adult females of Tetranychus cinnabarinus Boisd. A time-dose mortality model (TDM) was established, which passed the Hosmer-Lemeshow test. The sensitivity of the adult females to the concentration change of the acaricides was in the sequence of scopoletin > optimal mass ratio of scopoletin to BDMC > BDMC. The peak mortality of the female adults was found at 32, 28 and 32 h after treated with BDMC, scopoletin, and their combination at the optimal mass ratio, respectively. The values of the LC50 and LC90 at 48 h after treated with BDMC, scopoletin, and their combination at the optimal mass ratio were 0.3324, 0.2035 and 0.2195 mg x mL(-1), and 2.1198, 0.9521 and 1.1617 mg x mL(-1), and the median lethal time (LT50) of BDMC, scopoletin, and their combination at the optimal mass ratio was 7.4, 6.0 and 6.1 h at the concentration 1.0 mg x mL(-1), and 6.4, 4.8 and 5.0 h at the concentration 2.0 mg x mL(-1), respectively. The acaricidal activity and time-dose response of the optimal combination of scopoletin and BDMC were closer to those of scopoletin, suggesting a synergistic acaricidal activity of the combination of scopoletin and BDMC, which was worthy to be developed for application.
authors.affiliation: College of Plant Protection, Southwest University, Chongqing 400716, China. zhenguoyang@qq.com
authors.forename: Zhen-Guo
authors.initials: ZG
authors.lastname: Yang
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Ding
authors.forename: Jin-Xiang
authors.initials: JX
authors.lastname: Luo
mesh_terms: D056810:Acaricides / Q000494:pharmacology*; D000818:Animals; D003474:Curcumin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D036381:Diarylheptanoids; D004357:Drug Synergism; D005260:Female; D010936:Plant Extracts / Q000494:pharmacology; D012603:Scopoletin / Q000302:isolation & purification / Q000494:pharmacology*; D040102:Tetranychidae / Q000187:drug effects*
chemical_list: D056810:Acaricides; D036381:Diarylheptanoids; D010936:Plant Extracts; C034786:bisdemethoxycurcumin; D003474:Curcumin; D012603:Scopoletin