title: CLIP-HSQMBC: easy measurement of small proton-carbon coupling constants in organic molecules.
abstract: A user-friendly 2D NMR approach denoted as CLIP-HSQMBC is proposed for the very easy, direct and accurate measurement of long-range proton-carbon coupling constants in organic molecules and natural products. The J value can be extracted directly from the analysis of resolved in-phase (1)H multiplets that show an additional splitting arising from the proton-carbon coupling. In cases of unresolved peaks, a simple fitting analysis using the internal satellite lines as a reference is performed. Addition of a spin-lock period results in a CLIP-HSQMBC-TOCSY experiment that is suitable for the measurement of very small coupling values or to observe correlations from overlapped resonances.
authors.affiliation: Servei de Ressonància Magnètica Nuclear, Universitat Autònoma de Barcelona, 08193-Bellaterra, Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Saurí
authors.forename: Teodor
authors.initials: T
authors.lastname: Parella
authors.forename: Juan F
authors.initials: JF
authors.lastname: Espinosa
mesh_terms: D002244:Carbon / Q000737:chemistry*; D003292:Convulsants / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011522:Protons; D013331:Strychnine / Q000737:chemistry
chemical_list: D003292:Convulsants; D011522:Protons; D002244:Carbon; D013331:Strychnine