title: The clinical application of array CGH for the detection of chromosomal defects in 20,126 unselected newborns.
abstract: BACKGROUND
  Array comparative genomic hybridization (CGH) is a powerful tool for detecting unbalanced chromosomal alterations. To validate the usefulness of array CGH in newborn screening, we examined 20,126 unselected infants. In addition, the number of newborns analyzed with array CGH is the largest one ever reported.
  
  
  RESULTS
  A total of 20,126 unselected newborns were investigated with array CGH and cytogenetic analyses. The analyses revealed 87 cases with chromosome abnormalities. Of these, 53 cases had significant chromosome aneuploidies, including trisomy 13, trisomy 21, 47,XXY or 45,X, and the other 34 cases presented partial chromosomal deletions or duplications.
  
  
  CONCLUSIONS
  In this study, we show that array CGH is an appropriate tool for the screening of chromosomal abnormalities in newborns, especially for the infants without distinct clinical features.
authors.affiliation: MG MED, Inc,, 60-24, Gasan-dong, Seoul, Korea. ceo@mgmed.com.
authors.forename: Sang-Jin
authors.initials: SJ
authors.lastname: Park
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Jung
authors.forename: Ran-Suk
authors.initials: RS
authors.lastname: Ryu
authors.forename: Hyun Woong
authors.initials: HW
authors.lastname: Kang
authors.forename: He Doo
authors.initials: HD
authors.lastname: Chung
authors.forename: Ho-Young
authors.initials: HY
authors.lastname: Kang