title: Complex regulatory network of microRNAs, transcription factors, gene alterations in adrenocortical cancer.
abstract: Several lines of evidence indicate that cancer is a multistep process. To survey the mechanisms involving gene alteration and miRNAs in adrenocortical cancer, we focused on transcriptional factors as a point of penetration to build a regulatory network. We derived three level networks: differentially expressed; related; and global. A topology network ws then set up for development of adrenocortical cancer. In this network, we found that some pathways with differentially expressed elements (genetic and miRNA) showed some self-adaption relations, such as EGFR. The differentially expressed elements partially uncovered mechanistic changes for adrenocortical cancer which should guide medical researchers to further achieve pertinent research.
authors.affiliation: Computer Science and Technology Department, Jilin University, Changchun, China. Zhangb999@sina.cn
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Zhi-Wen
authors.initials: ZW
authors.lastname: Xu
authors.forename: Kun-Hao
authors.initials: KH
authors.lastname: Wang
authors.forename: Tian-Cheng
authors.initials: TC
authors.lastname: Lu
authors.forename: Ye
authors.initials: Y
authors.lastname: Du
mesh_terms: D018268:Adrenocortical Carcinoma / Q000235:genetics* / Q000378:metabolism; D019295:Computational Biology; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D014157:Transcription Factors