title: Self-assembly of near-monodisperse redox-sensitive micelles from cholesterol-conjugated biomimetic copolymers.
abstract: Poly(D,L-lactide)-SS-poly(2-methacryloyloxyethyl phosphorylcholine) block copolymers conjugated with cholesterol are synthesized by ROP and ATRP using a novel kind of double-dead initiator. This facile strategy not only can endue block copolymers with disulfide bonds, but can also overcome the disadvantages inherent in the synthesis procedure for the copolymers. The resultant biomimetic copolymers can self-assemble into near-monodisperse micelles. Subsequently, they are used as a carrier to encapsulate a hydrophobic dye, and the release can be triggered by a redox reagent, dithiothreitol. MTT study shows that the as-prepared micelles has good biocompatibility to both normal and cancer cells. These properties indicate that these micelles may be used as promising drug delivery vehicles.
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
authors.forename: Gongyan
authors.initials: G
authors.lastname: Liu
authors.forename: Xiangsheng
authors.initials: X
authors.lastname: Liu
authors.forename: Qiao
authors.initials: Q
authors.lastname: Jin
authors.forename: Jian
authors.initials: J
authors.lastname: Ji
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D045744:Cell Line, Tumor; D002784:Cholesterol / Q000737:chemistry / Q000378:metabolism; D004229:Dithiothreitol / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D056945:Hep G2 Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008823:Micelles; D010084:Oxidation-Reduction; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D011109:Polymethacrylic Acids / Q000737:chemistry / Q000378:metabolism
chemical_list: D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D011109:Polymethacrylic Acids; C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine; D002784:Cholesterol; D004229:Dithiothreitol
keywords: atom transfer radical polymerization (ATRP); micelles; redox polymers; ring-opening polymerization; self-assembly