title: Prospective validation that vulnerable plaque associated with major adverse outcomes have larger plaque volume, less dense calcium, and more non-calcified plaque by quantitative, three-dimensional measurements using intravascular ultrasound with radiofrequency backscatter analysis : results from the ATLANTA I Study.
abstract: Whether quantitative, two-dimensional, and three-dimensional plaque measurements by intravascular ultrasound with radiofrequency backscatter (IVUS/VH) are different between intermediate lesions with or without major adverse cardiovascular events (MACE) is unknown. IVUS/VH-derived parameters were compared in 60 patients with an intermediate coronary lesion (40-70 %) between lesions that did or did not result in MACE over 12 months. IVUS/VH measurements were done at the site of the minimal lumen area (MLA) and on a per-plaque basis, defined by 40 % plaque burden. Pre-specified, adjudicated MACE events occurred in 5 of 60 patients (8.3 %). MACE lesions had larger plaque burden (65 % vs. 53 %, p = 0.004), less dense calcium (6.6 % vs. 14.7 %, p = 0.05), and more non-calcified plaque, mostly fibrofatty kind (17.6 % vs. 10 %, p = 0.02). Intermediate coronary lesions associated with MACE at 12 months have more plaque, less dense calcium, and more non-calcified plaque, particularly fibrofatty tissue by IVUS/VH.
authors.affiliation: Atlanta Medical Center, Atlanta, GA, USA, ggus@hotmail.com.
authors.forename: Jesus G
authors.initials: JG
authors.lastname: Vazquez-Figueroa
authors.forename: Sarah
authors.initials: S
authors.lastname: Rinehart
authors.forename: Zhen
authors.initials: Z
authors.lastname: Qian
authors.forename: Parag H
authors.initials: PH
authors.lastname: Joshi
authors.forename: Abhinav
authors.initials: A
authors.lastname: Sharma
authors.forename: James
authors.initials: J
authors.lastname: Lee
authors.forename: Hunt
authors.initials: H
authors.lastname: Anderson
authors.forename: Laura
authors.initials: L
authors.lastname: Murrieta
authors.forename: Charles
authors.initials: C
authors.lastname: Wilmer
authors.forename: Harold
authors.initials: H
authors.lastname: Carlson
authors.forename: Kenneth
authors.initials: K
authors.lastname: Taylor
authors.forename: William
authors.initials: W
authors.lastname: Ballard
authors.forename: Dimitri
authors.initials: D
authors.lastname: Karmpaliotis
authors.forename: Anna
authors.initials: A
authors.lastname: Kalynych
authors.forename: Charles
authors.initials: C
authors.lastname: Brown
authors.forename: Szilard
authors.initials: S
authors.lastname: Voros
mesh_terms: D000368:Aged; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D018450:Disease Progression; D005260:Female; D005355:Fibrosis; D005845:Georgia; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009336:Necrosis; D016017:Odds Ratio; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D015203:Reproducibility of Results; D012307:Risk Factors; D012542:Scattering, Radiation; D012720:Severity of Illness Index; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional / Q000379:methods*; D061205:Vascular Calcification / Q000150:complications / Q000000981:diagnostic imaging*