title: A time-resolved PHIP-NMR method applied to the asymmetric homogeneous hydrogenation of β-dehydroamino acids.
abstract: A new NMR technique based on parahydrogen-induced polarisation (PHIP) is presented, that allows the catalytic enantioselective hydrogenation of prochiral substrates to be monitored (see scheme, the left-hand side arises from the hydrogenation of a prochiral alkene). The approach takes into consideration the kinetics of hydrogenation as well as the relaxation of polarisation. The use of parahydrogen temporarily generates diastereomers which can be monitored as a function of time where otherwise only enantiomers are formed.
authors.affiliation: Institut für Physikalische und Theoretische Chemie der Universität Bonn, Wegelerstrasse 12, 53115 Bonn, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Wildschütz
authors.forename: P
authors.initials: P
authors.lastname: Hübler
authors.forename: J
authors.initials: J
authors.lastname: Bargon
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism; D013997:Time Factors
chemical_list: D000596:Amino Acids