title: High-risk variants of cutaneous squamous cell carcinoma in patients with discoid lupus erythematosus: a case series.
abstract: Cutaneous squamous cell carcinoma, the second most common form of non-melanotic skin cancer, may develop in long-standing discoid lesions, especially those that are depigmented and located in sun-exposed areas. The clinical course of this complication may be aggressive, with early metastases and a risk of mortality. We report three cases demonstrating this emerging trend of secondary squamous cell carcinoma in discoid lesions as the incidence of this secondary malignancy in other diseased skin lesions is on the decline.
authors.affiliation: Faculty of Medical Sciences, The University of the West Indies, St Michael, Barbados. cflower@caribsurf.com
authors.forename: C
authors.initials: C
authors.lastname: Flower
authors.forename: D
authors.initials: D
authors.lastname: Gaskin
authors.forename: S
authors.initials: S
authors.lastname: Bhamjee
authors.forename: Z
authors.initials: Z
authors.lastname: Bynoe
mesh_terms: D000293:Adolescent; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects
keywords: Squamous cell carcinoma; discoid lupus erythematosus; systemic lupus erythematosus