title: Association between Tumor Characteristics and Bone Mineral Density in Postmenopausal Breast Cancer Patients.
abstract: The aim of this study was to evaluate the association of bone mineral density (BMD) at the time of diagnosis with clinical-pathologic findings in patients with operable postmenopausal breast cancer. One hundred and fifty-eight postmenopausal women who had a baseline lumbar and hip BMD measurement were included in the analysis. Patients were divided into two groups based on the median BMD. p ≤ 0.002 was considered to be statistically significant. Hormone replacement therapy (HRT) use longer than 5 years was associated with increased lumbar BMD compared with patients who used HRT less than 5 years (p = 0.002). Patients with higher BMD tended to have low grade disease, no lympho-vascular invasion, progesterone receptor-positive tumors, and low Ki-67 levels (p < 0.05). Higher baseline BMD in postmenopausal patients with breast cancer is associated with favorable prognostic features.
authors.affiliation: Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030-4009, USA. soley.bayraktar@gmail.com
authors.forename: Soley
authors.initials: S
authors.lastname: Bayraktar
authors.forename: Tiffany
authors.initials: T
authors.lastname: Avery
authors.forename: Kadri
authors.initials: K
authors.lastname: Altundag
authors.forename: Kristine
authors.initials: K
authors.lastname: Broglio
authors.forename: Banu K
authors.initials: BK
authors.lastname: Arun
mesh_terms: D000368:Aged; D015519:Bone Density; D001943:Breast Neoplasms / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006615:Hip; D020249:Hormone Replacement Therapy; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008159:Lumbar Vertebrae; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D017698:Postmenopause; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012044:Regression Analysis; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D019394:Ki-67 Antigen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
keywords: bone mineral density; breast cancer; postmenopausal; prognostic factors