title: [Expression of SOX2 protein and its clinical significance in laryngeal carcinoma].
abstract: OBJECTIVE
  To investigate the expression of SOX2 in laryngeal carcinoma and analyze the relation of SOX2 and clinical factors.
  
  
  METHODS
  We measured the expression of SOX2 protein in 45 laryngeal carcinoma fresh samples and 45 paracarcinoma tissues (cutting margin > 0.5 cm) with flow cytometer (Epics-XL II), 20 normal laryngeal mucosa samples were also studied as controls.
  
  
  RESULTS
  The quantitative and qualitative expression of SOX2 protein in laryngeal carcinoma tissues was obviously higher than those in paracarcinoma and in normal laryngeal mucosa tissues respectively (P < 0 05). There was no significant difference between the expression of paracarcinoma and normal laryngeal mucosa tissues. In laryngeal carcinoma, the expression of SOX2 protein wasn't significantly related to patients' clinical classification, tumor size, smoking history, patients' age and sex but related to metastasis, pathological grade and clinical stage.
  
  
  CONCLUSIONS
  The high expression of SOX2 may contribute to the carcinogenesis and development of laryngeal carcinoma. It is an important index of judging metastasis and staging and prognosis of laryngeal carcinoma to measure the expression of SOX2 protein.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Zhongshan, Sun Yat-sen University, Zhongshan 528403, China. yefei5620@163.com
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.forename: Guiqiu
authors.initials: G
authors.lastname: Huang
authors.forename: Minyi
authors.initials: M
authors.lastname: Fu
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Ma
authors.forename: Hongjian
authors.initials: H
authors.lastname: Kang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D055748:SOXB1 Transcription Factors / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors