title: Salimabromide: unexpected chemistry from the obligate marine myxobacterium Enhygromxya salina.
abstract: Marine myxobacteria (Enhygromyxa, Plesiocystis, Pseudoenhygromyxa, Haliangium) are phylogenetically distant from their terrestrial counterparts. Salimabromide is the first natural product from the Plesiocystis/Enhygromyxa clade of obligatory marine myxobacteria. Salimabromide has a new tetracyclic carbon skeleton, comprising a brominated benzene ring, a furano lactone residue, and a cyclohexane ring, bridged by a seven-membered cyclic moiety. The absolute configuration was deduced from experimental and calculated CD data. Salimabromide revealed antibiotic activity towards Arthrobacter cristallopoietes.
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Felder
authors.forename: Sandra
authors.initials: S
authors.lastname: Dreisigacker
authors.forename: Stefan
authors.initials: S
authors.lastname: Kehraus
authors.forename: Edith
authors.initials: E
authors.lastname: Neu
authors.forename: Gabriele
authors.initials: G
authors.lastname: Bierbaum
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Wright
authors.forename: Dirk
authors.initials: D
authors.lastname: Menche
authors.forename: Till F
authors.initials: TF
authors.lastname: Schäberle
authors.forename: Gabriele M
authors.initials: GM
authors.lastname: König
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D059001:Aquatic Organisms; D001173:Arthrobacter / Q000187:drug effects; D006576:Heterocyclic Compounds, 4 or More Rings / Q000302:isolation & purification* / Q000494:pharmacology; D009231:Myxococcales / Q000737:chemistry* / Q000235:genetics; D010802:Phylogeny
chemical_list: D000900:Anti-Bacterial Agents; D006576:Heterocyclic Compounds, 4 or More Rings; C585225:salimabromide
keywords: NMR spectroscopy; enhygromyxa; myxobacteria; natural products; polyketides