title: A common gene variant in STK11 is associated with metabolic risk markers and diabetes during gestation.
abstract: OBJECTIVE
  To assess whether the common rs8111699 (C528G) variant in STK11 is related to metabolic risk markers in pregnant women and to gestational diabetes mellitus (GDM).
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Hospital.
  
  
  METHODS
  A total of 561 pregnant women: 318 without and 243 with GDM (National Diabetes Data Group criteria).
  
  
  METHODS
  None.
  
  
  METHODS
  rs8111699 variant in STK11 (Taqman technology). Fasting glucose, insulin (homeostatic model assessment of insulin resistance and β-cell function [HOMA-IR and -β]) and C-peptide assessed at 24-28 weeks' gestation.
  
  
  RESULTS
  In non-GDM women, the G allele in rs8111699 was associated with lower HOMA-IR (CC: 1.3 ± 0.1 mIU/L; GG: 0.9 ± 0.1 mIU/L) and HOMA-β (CC: 165 ± 20 mIU/L; GG: 118 ± 10 mIU/L). In GDM women, the G allele was related to lower body mass index (BMI; CC: 27.9 ± 1.0 kg/m(2); GG: 24.5 ± 0.6 kg/m(2)) and C-peptide (CC: 2.3 ± 0.1 ng/mL; GG: 1.6 ± 0.1 ng/mL). The GG genotype was less frequently observed in GDM women (18% vs. 26%), particularly in heavier GDM women (BMI > median: 14% vs. 28%).
  
  
  CONCLUSIONS
  In pregnant women, the G allele for the rs8111699 variant in STK11 is associated with a more favorable metabolic phenotype and may protect against the development of GDM, particularly in heavier women.
authors.affiliation: Department of Pediatrics, Dr. Josep Trueta Hospital, Girona, Spain.
authors.forename: Judit
authors.initials: J
authors.lastname: Bassols
authors.forename: Ana
authors.initials: A
authors.lastname: Megia
authors.forename: Pilar
authors.initials: P
authors.lastname: Soriano-Rodríguez
authors.forename: Marta
authors.initials: M
authors.lastname: Díaz
authors.forename: Anna
authors.initials: A
authors.lastname: Prats-Puig
authors.forename: Magdalena
authors.initials: M
authors.lastname: Gifre
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Simón-Muela
authors.forename: Sara
authors.initials: S
authors.lastname: Torrent
authors.forename: Anna C
authors.initials: AC
authors.lastname: Borrell
authors.forename: Joan-Carles
authors.initials: JC
authors.lastname: Riera-Socasau
authors.forename: Joan
authors.initials: J
authors.lastname: Vendrell
authors.forename: Francis
authors.initials: F
authors.lastname: de Zegher
authors.forename: Lourdes
authors.initials: L
authors.lastname: Ibáñez
authors.forename: Abel
authors.initials: A
authors.lastname: López-Bermejo
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D008659:Metabolic Diseases / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000502:physiology; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases
keywords: STK11; gestational diabetes; insulin; polymorphism