title: Gene expression profiling reveals distinct features of various porcine adipose tissues.
abstract: BACKGROUND
  The excessive accumulation of body fat is a major risk factor to develop a variety of metabolic diseases. To investigate the systematic association between the differences in gene expression profiling and adipose deposition, we used pig as a model, and measured the gene expression profiling of six variant adipose tissues in male and females from three pig breeds which display distinct fat level.
  
  
  RESULTS
  We identified various differential expressed genes among breeds, tissues and between sexes, and further used a clustering method to identify sets of functionally co-expression genes linked to different obesity-related phenotypes. Our results reveal that the subcutaneous adipose tissues mainly modulate metabolic indicators, nonetheless, the visceral adipose tissues as well as the intermuscular adipose tissue were mainly associated with the impaired inflammatory and immune response.
  
  
  CONCLUSIONS
  The present study provided the evidence of gene expression profiling that the subcutaneous adipose tissues are mainly affected the metabolism process, whereas the visceral and intermuscular adipose tissues should been term as the metabolic risk factors of obesity.
authors.affiliation: Institute of Animal Genetics & Breeding, College of Animal Science & Technology, Sichuan Agricultural University, Ya'an, Sichuan 625000, China.
authors.forename: Chaowei
authors.initials: C
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Jideng
authors.initials: J
authors.lastname: Ma
authors.forename: Anan
authors.initials: A
authors.lastname: Jiang
authors.forename: Guoqing
authors.initials: G
authors.lastname: Tang
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Mai
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.forename: Lin
authors.initials: L
authors.lastname: Bai
authors.forename: Mingzhou
authors.initials: M
authors.lastname: Li
authors.forename: Xuewei
authors.initials: X
authors.lastname: Li
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008659:Metabolic Diseases / Q000235:genetics* / Q000473:pathology; D009765:Obesity / Q000235:genetics / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D012307:Risk Factors; D050151:Subcutaneous Fat / Q000378:metabolism* / Q000473:pathology; D013552:Swine