title: Factors affecting time to revision sinus surgery for nasal polyps: a 25-year experience.
abstract: OBJECTIVE
  Surgical treatment for chronic rhinosinusitis with nasal polyps (CRSwNP) is often followed by polyp regrowth with return of symptoms. The purpose of this study is to identify clinical factors that influence the time interval to revision sinus surgery in patients with nasal polyps.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Records of 299 individuals who underwent two or more surgeries for the diagnosis of nasal polyps by the senior author (RM) from 1987 through 2011 were reviewed. The time between surgical interventions were compared to patient demographics, comorbidities, endoscopic examination, computed tomography (CT) stage, extent of surgery, and pathologic findings.
  
  
  RESULTS
  The mean time interval between polyp surgeries was 4.87 ± 3.61 years (range 0.7-18.6 years). The median time to revision surgery was shorter in patients who smoked compared to nonsmokers (2.82 vs. 4.31 years, respectively, P = .022) and longer in patients who underwent middle turbinate resection rather than preservation (4.56 vs. 3.93 years, respectively, P = .048). Kaplan-Meier survival analysis confirmed these findings, but the beneficial effect of turbinectomy appeared to dissipate by 8 years. Neither a history of asthma nor advanced CT stage influenced the time to revision surgery.
  
  
  CONCLUSIONS
  The time course between sinus surgeries in patients with regrowth of nasal polyps appears to be affected by certain modifiable extrinsic factors, including smoking on the part of the patient and operative technique on the part of the surgeon. The performance of middle turbinate resection during sinus surgery appears to extend the time interval until a revision procedure is required.
authors.affiliation: Department of Otolaryngology (A.W.W., J.Y.T., H.S.T., R.M.), Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology, Harvard Medical School; and the, Boston University School of Medicine, Boston, Massachusetts, U.S.A.
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Wu
authors.forename: Jonathan Y
authors.initials: JY
authors.lastname: Ting
authors.forename: Michael P
authors.initials: MP
authors.lastname: Platt
authors.forename: Hien T
authors.initials: HT
authors.lastname: Tierney
authors.forename: Ralph
authors.initials: R
authors.lastname: Metson
mesh_terms: D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D009298:Nasal Polyps / Q000601:surgery*; D059747:Nasal Surgical Procedures / Q000379:methods*; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed
keywords: Nasal polyps; chronic rhinosinusitis; endoscopic sinus surgery; revision sinus surgery