title: MCM loading--an open-and-shut case?
abstract: Two recent studies, from Fernández-Cid et al. (2013) (this issue of Molecular Cell) and Frigola et al. (2013), have elegantly dissected key events and interactions in the loading of the budding yeast replicative helicase MCM(2-7).
authors.affiliation: Department of Molecular and Cellular Biochemistry, Indiana University, Simon Hall MSB, 212 S Hawthorne Drive, Bloomington, IN 47405, USA.
authors.forename: Rachel Y
authors.initials: RY
authors.lastname: Samson
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Bell
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D004261:DNA Replication / Q000235:genetics*; D046912:Multiprotein Complexes / Q000378:metabolism*; D051738:Origin Recognition Complex / Q000378:metabolism*; D018741:Replication Origin / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
chemical_list: C066503:CDC6 protein, S cerevisiae; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D046912:Multiprotein Complexes; C497214:ORC1 protein, S cerevisiae; D051738:Origin Recognition Complex; D029701:Saccharomyces cerevisiae Proteins; D000251:Adenosine Triphosphatases; C069199:MCM2 protein, S cerevisiae