title: TRIM39R, but not TRIM39B, regulates type I interferon response.
abstract: Behcet's disease (BD) is a chronic relapsing inflammatory autoimmune disease characterized by recurrent oral and genital ulcers, skin legions and uveitis and its pathogenesis is not fully elucidated. Previously we identified that two novel susceptible SNPs are associated with BD. One is located in putative RNF39 promoter region, another is located on TRIM39 coding exon. In this study, in order to identify the molecular function of TRIM39, we established gain-of-function of TRIM39 related genes and thus, performed microarray analysis. Our results indicate that TRIM39R, but not TRIM39B, regulates type I interferon response.
authors.affiliation: Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Riho
authors.initials: R
authors.lastname: Kurata
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tajima
authors.forename: Tomo
authors.initials: T
authors.lastname: Yonezawa
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
mesh_terms: D001528:Behcet Syndrome / Q000235:genetics / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D057809:HEK293 Cells; D006801:Humans; D007249:Inflammation; D007370:Interferon Type I / Q000378:metabolism*; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D044767:Ubiquitin-Protein Ligases; D014777:Virus Diseases / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D007370:Interferon Type I; C414583:TRIM39 protein, human; D044767:Ubiquitin-Protein Ligases