title: The promoting effect of Ishige sinicola on hair growth.
abstract: This study was conducted to evaluate the promoting effect of Ishige sinicola, an alga native to Jeju Island, Korea, on hair growth. When vibrissa follicles were cultured in the presence of I. sinicola extract for 21 days, I. sinicola extract increased hair-fiber length. After topical application of I. sinicola extract onto the back of C57BL/6 mice, anagen progression of the hair shaft was induced. The I. sinicola extract significantly inhibited the activity of 5α-reductase. Treatment of immortalized vibrissa dermal papilla cells (DPCs) with I. sinicola extract resulted in increase of cell proliferation, which was accompanied by the increase of phospho-GSK3β level, β-catenin, Cyclin E and CDK2, whereas p27kip1 was down-regulated. In particular, octaphlorethol A, an isolated component from the I. sinicola extract, inhibited the activity of 5α-reductase and increased the proliferation of DPCs. These results suggest that I. sinicola extract and octaphlorethol A, a principal of I. sinicola, have the potential to treat alopecia via the proliferation of DPCs followed by the activation of β-catenin pathway, and the 5α-reductase inhibition.
authors.affiliation: Department of Medicine, School of Medicine, Institute of Medical Sciences, Jeju National University, 102 Jejudaehakno, Jeju 690-756, Korea.
authors.forename: Jung-Il
authors.initials: JI
authors.lastname: Kang
authors.forename: Eun-Ji
authors.initials: EJ
authors.lastname: Kim
authors.forename: Min-Kyoung
authors.initials: MK
authors.lastname: Kim
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Jeon
authors.forename: Sung-Myung
authors.initials: SM
authors.lastname: Kang
authors.forename: Young-Sang
authors.initials: YS
authors.lastname: Koh
authors.forename: Eun-Sook
authors.initials: ES
authors.lastname: Yoo
authors.forename: Hee-Kyoung
authors.initials: HK
authors.lastname: Kang
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006197:Hair / Q000187:drug effects* / Q000254:growth & development; D018859:Hair Follicle / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D000459:Phaeophyceae / Q000737:chemistry*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D056910:Republic of Korea; D014738:Vibrissae / Q000187:drug effects / Q000378:metabolism; D051176:beta Catenin / Q000187:drug effects / Q000378:metabolism
chemical_list: D058891:5-alpha Reductase Inhibitors; D010636:Phenols; D051176:beta Catenin; C572462:octaphlorethol A