title: Recent insights in the removal of Klebseilla pathogenicity factors for the industrial production of 2,3-butanediol.
abstract: 2,3-Butanediol (2,3-BDO) has immense industrial applications. Recently, microbial fermentation has emerged as an alternative way to produce this industrially important chemical. Although 2,3-BDO is produced by several microorganisms, the Klebsiella genera has an excellent production compared with other 2,3-BDO-producing microorganisms. In order to produce 2,3- BDO on a large scale, the challenges of removing pathogenic factors from Klebsiella pneumoniae need to be addressed. K. pneumoniae produces a number of virulence factors that contribute to its pathogenesis, including lipopolysaccharides, capsules, fimbrial adhesins, etc. Removal of these pathogenic factors from 2,3-BDO-producing Klebsiella strains will result in avirulent strains for the safe, economic, and efficient production of 2,3-BDO. In this review, we summarize the current trends in 2,3-BDO production using K. pneumoniae and insights into the removal of its virulence factors for industrial applications.
authors.affiliation: Institute of Life Sciences and Resources, and Department of Food Science and Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 446-701, Republic of Korea.
authors.forename: Anupama
authors.initials: A
authors.lastname: Shrivastav
authors.forename: Jinwon
authors.initials: J
authors.lastname: Lee
authors.forename: Hae-Yeong
authors.initials: HY
authors.lastname: Kim
authors.forename: Young-Rok
authors.initials: YR
authors.lastname: Kim
mesh_terms: D002072:Butylene Glycols / Q000378:metabolism*; D017353:Gene Deletion; D007711:Klebsiella pneumoniae / Q000235:genetics* / Q000378:metabolism* / Q000472:pathogenicity; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D002072:Butylene Glycols; D037521:Virulence Factors; C026978:2,3-butylene glycol