title: Drug and alcohol trajectories among adults with schizophrenia: data from the CATIE study.
abstract: OBJECTIVE
  The primary aim is to describe drug and alcohol trajectories in adults with schizophrenia.
  
  
  METHODS
  Growth mixture models were used to examine disordered and non-disordered use and abstinence in the Clinical Antipsychotic Trials of Intervention Effectiveness study.
  
  
  RESULTS
  Five classes - always abstinent; fluctuating use, abuse, and occasional abstinence; occasional (ab)use; stopped (ab)use; abusing - fit best. Overlap exists between always abstinent drug and alcohol classes; less overlap exists across other classes.
  
  
  CONCLUSIONS
  There is heterogeneity in drug and alcohol use among adults with schizophrenia. The lack of overlap between classes, save always abstinent, suggests modeling drug and alcohol use separately.
authors.affiliation: RTI International, 3040 E. Cornwallis Road, P.O. Box 12194, Research Triangle Park, NC 27709, United States. rvandorn@rti.org
authors.forename: Richard A
authors.initials: RA
authors.lastname: Van Dorn
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Desmarais
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Tueller
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Jolley
authors.forename: Kiersten L
authors.initials: KL
authors.lastname: Johnson
authors.forename: Marvin S
authors.initials: MS
authors.lastname: Swartz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000628:therapy; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy* / Q000453:epidemiology*; D019966:Substance-Related Disorders / Q000453:epidemiology*; D013997:Time Factors; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents
keywords: Alcohol use; Drug use; Growth mixture model; Longitudinal; Schizophrenia