title: Clinical and electroretinographic findings of progressive retinal atrophy in miniature schnauzer dogs of South Korea.
abstract: The purpose of the study was to describe the clinical and electroretinographic features of clinical cases of progressive retinal atrophy (PRA) in miniature schnauzer (MS) of South Korea. Sixty-six MS (14 normal and 52 affected) were included. All animals underwent routine ocular examinations. Electroretinogram (ERG) was recorded in the 14 normal and 15 affected dogs. For normal dogs, the mean age ± SD was 4.1 ± 2.4 years (1 to 9 years), and there were no ocular abnormalities on the basis of ocular examinations and ERG results. For the PRA-affected dogs, it was shown that the mean age ± SD was 4.3 ± 1.1 years (2 to 7 years), and 44 dogs (84.6%) were 3 to 5 years old. Most of the PRA-affected dogs had abnormal menace responses (98.1%) and pupillary light reflexes (PLRs, 88.5%); some dogs showed normal menace response (1.9%) and PLRs (11.5%). Ophthalmoscopic abnormalities in the affected group included one or more of the following changes: hyperreflectivity and discoloration of the tapetal area, attenuation of retinal vessels, depigmentation in non-tapetal area and optic disc atrophy. ERG in the affected dogs showed non-recordable responses in all cases tested with clinical signs of PRA. The present study showed that PRA in MS was mainly observed between the age of 3 to 5 years. ERG revealed abnormal rod and cone responses in affected dogs at the ages studied.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
authors.forename: Man Bok
authors.initials: MB
authors.lastname: Jeong
authors.forename: Shin Ae
authors.initials: SA
authors.lastname: Park
authors.forename: Se Eun
authors.initials: SE
authors.lastname: Kim
authors.forename: Young Woo
authors.initials: YW
authors.lastname: Park
authors.forename: Kristina
authors.initials: K
authors.lastname: Narfström
authors.forename: Kangmoon
authors.initials: K
authors.lastname: Seo
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000235:genetics / Q000473:pathology*; D004285:Dogs; D004596:Electroretinography / Q000662:veterinary; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D008297:Male; D056910:Republic of Korea; D012162:Retinal Degeneration / Q000235:genetics / Q000473:pathology / Q000662:veterinary*