title: Diversity of killer cell immunoglobulin-like receptor genes in uveitis associated with autoimmune diseases: ankylosing spondylitis and Behçet disease.
abstract: OBJECTIVE
  To determine whether the frequencies of specific killer cell immunoglobulin-like receptors (KIR) genotypes are associated with the incidence of uveitis in ankylosing spondylitis (AS) and Behçet disease (BD).
  
  
  METHODS
  The authors analyzed the frequency of 16 KIR genes in Koreans with either AS (110 patients, all HLA-B27-positive) or BD (86 patients), using polymerase chain reaction sequence-specific oligonucleotide probing.
  
  
  RESULTS
  The frequency of the inhibitory receptor KIR3DL1 was lower in AS patients affected by uveitis than that in the general population (p < 0.05). The frequency of the KIR3DL1(-)/2DS3(-) was significantly higher in AS patients with uveitis (odds ratio = 9.306, p = 0.007).
  
  
  CONCLUSIONS
  The study suggests that KIR3DL1 might associate with the resistance to AS-associated uveitis by influencing natural killer cell activity.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South Korea.
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Moon
authors.forename: Eun-Jee
authors.initials: EJ
authors.lastname: Oh
authors.forename: Yonggoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Kyu Seop
authors.initials: KS
authors.lastname: Kim
authors.forename: Seung-Ki
authors.initials: SK
authors.lastname: Kwok
authors.forename: Ji Hyeon
authors.initials: JH
authors.lastname: Ju
authors.forename: Kyung-Su
authors.initials: KS
authors.lastname: Park
authors.forename: Ho-Youn
authors.initials: HY
authors.lastname: Kim
authors.forename: Sung-Hwan
authors.initials: SH
authors.lastname: Park
mesh_terms: D000328:Adult; D000483:Alleles; D001528:Behcet Syndrome / Q000150:complications* / Q000276:immunology; D004247:DNA / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015796:HLA-B27 Antigen / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D054340:Receptors, KIR / Q000235:genetics* / Q000378:metabolism; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000276:immunology; D014605:Uveitis / Q000209:etiology / Q000235:genetics* / Q000276:immunology
chemical_list: D015796:HLA-B27 Antigen; D054340:Receptors, KIR; D004247:DNA