title: [The specificity between "fei and dachang" in the lung injury of rats with ulcerative colitis].
abstract: OBJECTIVE
  To observe the features of bronchopulmonary lesions in ulcerative colitis (UC) rats and the specificity with Fei and Dachang, thus providing reliance for the theory of "intestinal diseases involved Fei".
  
  
  METHODS
  The UC rat model was duplicated by using rabbit intestine mucosa tissue allergenic model and TNBS-ethanol model. A normal rat group was set up as the control. The pulmonary functions [including inspiratory resistance (Ri), expiratory resistance (Re), forced vital capacity (FVC); FEV. 2/FVC, maximal voluntary ventilation (MVV), forced expiratory flow rate (FEF25% - 75%)], and indicators of liver and kidney functions [serum alanine aminotransferase (ALT), aspartate amino transferase (AST), blood urea nitrogen (BUN), and creatinine (Cr)] were detected in the two groups. The pathological changes of colon, lung, liver, and kidney were observed in the two groups.
  
  
  RESULTS
  Rats in the model group in both acute and chronic stages had weight loss, mucus and loose stool. Partial rats had such symptoms as dyspnea, shortness of breath, and wheezing. Compared with the normal group, the MW, FVC, FEV0.2 and FEF25% -75% in the acute stage; Ri, Re, MVV, FVC, and FEF25% - 75% in the chronic stage all significantly decreased (P <0.05, P <0.01), and FEV0.2/FVC significantly increased in the model group (P <0.05). The pathological results showed interstitial pneumonia and pulmonary interstitial fibrosis in the model group. But the indicators of liver and kidney functions were all in the normal range. No obvious pathological change was seen in the renal and liver tissues in the two groups.
  
  
  CONCLUSIONS
  UC could specifically induce bronchopulmonary lesions. Lung injury was one of UC's intestinal manifestations. The theory of "Fei and Dachang being interior-exteriorly correlated" was demonstrated from the theory of "intestinal diseases involved Fei".
authors.affiliation: Department of Gastroenterology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medcine, Beijing 100700, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.forename: Xin-yue
authors.initials: XY
authors.lastname: Wang
authors.forename: Xue
authors.initials: X
authors.lastname: Yang
authors.forename: Shan
authors.initials: S
authors.lastname: Jing
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.forename: Xiu-xia
authors.initials: XX
authors.lastname: Huang
authors.forename: Xu
authors.initials: X
authors.lastname: Jia
mesh_terms: D000818:Animals; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000473:pathology; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D055370:Lung Injury / Q000473:pathology*; D008297:Male; D008516:Medicine, Chinese Traditional; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley