title: Vitamin B12: chemical modifications.
abstract: Vitamin B12 plays a key role in many metabolic processes occurring in all mammals. Over the years its biological role has been extensively studied generating a lot of interest in the chemistry of this vital molecule. This established a variety of new methodologies for the synthesis and analysis of new cobalamin derivatives as well as creative purification techniques. This tutorial review summarizes all the advancements made in this area, providing a deeper insight into vitamin B12 chemistry.
authors.affiliation: Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Keith o
authors.initials: Ko
authors.lastname: óProinsias
authors.forename: Maciej
authors.initials: M
authors.lastname: Giedyk
authors.forename: Dorota
authors.initials: D
authors.lastname: Gryko
mesh_terms: D003035:Cobalt / Q000737:chemistry; D003038:Cobamides / Q000737:chemistry; D007769:Lactams / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D014805:Vitamin B 12 / Q000031:analogs & derivatives / Q000737:chemistry* / Q000378:metabolism
chemical_list: D003038:Cobamides; D007769:Lactams; D007783:Lactones; C017142:cobinamide; C012851:cobyric acid; C010895:cobyrinic acid; D003035:Cobalt; D014805:Vitamin B 12