title: Separation of ginseng active ingredients and their roles in cancer metastasis supplementary therapy.
abstract: In Traditional Chinese Medicine (TCM), ginseng roots are taken orally as a pharmacological adaptogen and nourishing stimulants for thousands of years. Along with the rapid advancement of modern life technologies, ginseng's effects as a non-toxic non-organ-specific cancer preventive agent have recently been elucidated both at molecular levels and on clinical aspects. Here we presented some techniques used for separating ginseng active ingredients, evidence of effects of ginseng and its ingredients on cancer and cancer metastasis obtained from in vitro and in vivo experiments and thousands of volunteers participated in various clinical trials. As a biological response modifier and an adaptogen to synergistically enhance efficacy of conventional therapy as a supplement, adequate ginseng consumption reduces the risk of development of all types of cancer and the recurrence of some types of cancer, improves host intrinsic response to cancer and quality of patients' life. We also briefly stated recent case reports on potential interaction between warfarin and ginseng products.
authors.affiliation: Cancer Metastasis Alert and Prevention Center, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Xie
authors.forename: Jingwei
authors.initials: J
authors.lastname: Shao
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Lu
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Chen
authors.forename: Jichuang
authors.initials: J
authors.lastname: Wang
authors.forename: Suhong
authors.initials: S
authors.lastname: Yu
authors.forename: Lee
authors.initials: L
authors.lastname: Jia
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D007155:Immunologic Factors / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D008516:Medicine, Chinese Traditional / Q000379:methods; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011788:Quality of Life
chemical_list: D007155:Immunologic Factors; D010936:Plant Extracts