title: [Influence of nuclear factor-kappa B inhibition on -SH groups concentration in liver of rats].
abstract: OBJECTIVE
  was to evaluate the influence of nuclear factor-kappaB inhibition on -SH groups concentration in liver of rat
  
  
  METHODS
  Experiments were performed on Wistar-Kyoto rats divided into following groups: group I (control) received saline; group II (ET-1) received endothelin 1 (12.5 microg/kg b.w.); Group III (BAY 11-7082) received a nuclear factor-kappaB (NF-kappaB) inhibitor (10 mg/kg b.w.); Group IV (BAY 11-7082+ET-1) received a nuclear factor-kappa B inhibitor (10 mg/kg b.w.) and 30 min later ET-1 (12.5 microg/kg b.w.).
  
  
  RESULTS
  Administration of endothelin 1 (ET-1) at a dose 12.5 microg/kg b.w. resulted in a statistically significant decrease in the concentration of -SH groups (p < 0.05 vs control). In contrast, BAY11-7082 (10 mg/kg b.w.) significantly increased the level of -SH groups in the liver in ET-1 inquced oxidative stress (p < 0.02).
  
  
  CONCLUSIONS
  A nuclear factor-kappa B inhibitor (BAY 11-7082) at a dose 10 mg/kg b.w. showed a significant increase in the concentration of -SH groups in the liver, in ET-1 induced oxidative stress.
authors.affiliation: Department of Cardiovascular Physiology, Medical University of Lodz, Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Michalski
authors.forename: Paulina
authors.initials: P
authors.lastname: Kleniewska
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Piechota-Polańczyk
authors.forename: Anna
authors.initials: A
authors.lastname: Goraca
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D019332:Endothelin-1 / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D009570:Nitriles / Q000494:pharmacology; D018384:Oxidative Stress; D051381:Rats; D011921:Rats, Inbred WKY; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013450:Sulfones / Q000494:pharmacology
chemical_list: C434003:3-(4-methylphenylsulfonyl)-2-propenenitrile; D000975:Antioxidants; D019332:Endothelin-1; D016328:NF-kappa B; D009570:Nitriles; D013438:Sulfhydryl Compounds; D013450:Sulfones; D052247:Nitric Oxide Synthase Type II