title: Comparison of the effect of endoscopic sinus surgery versus medical therapy on olfaction in nasal polyposis.
abstract: Chronic rhinosinusitis is a common inflammatory condition in western countries. Nasal polyposis has different symptoms such as nasal obstruction, anterior or posterior nasal drip, reduced sense of smell, and facial pain. Medical and endoscopic treatments are the two main treatments for nasal polyposis. Our aim was to compare the efficacy of different methods on olfactory function. This is a non-randomized clinical trial study that was done on 60 patients who were divided into two groups (medical and surgical). Patients were matched based on age, history of smoking, and the severity of obstruction. The radiologist score of Lund-Mackay staging system was used to match patients in two arms of the trial based on the severity of nasal obstruction. Patients in surgery groups underwent functional endoscopic sinus surgery under general anesthesia and then received Fluticasone propionate nasal spray for 8 weeks (400 mcg bd). Patients in the medical group were only prescribed with Fluticasone propionate with the same duration and same dose as mentioned. As a result of treatment protocol, both medical and surgical group experienced improvement in olfactory function but statistical analyses revealed that surgery resulted in better resolution of symptoms. Our observation revealed that combined treatment had a better effect than medical treatment in restoring olfaction in patients with nasal polyposis.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Rhinology Research Center, Shahid Sadoughi University of Medical Science and Health Services, Yazd, Iran, rhinology_research@ssu.ac.ir.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Baradaranfar
authors.forename: Zeynab Sadat
authors.initials: ZS
authors.lastname: Ahmadi
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Dadgarnia
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Bemanian
authors.forename: Saeid
authors.initials: S
authors.lastname: Atighechi
authors.forename: Ghasem
authors.initials: G
authors.lastname: Karimi
authors.forename: Abolhasan
authors.initials: A
authors.lastname: Halvani
authors.forename: Nasim
authors.initials: N
authors.lastname: Behniafard
authors.forename: Amin
authors.initials: A
authors.lastname: Baradaranfar
authors.forename: Tohid Emami
authors.initials: TE
authors.lastname: Meybodi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000730:Androstadienes / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004724:Endoscopy; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008297:Male; D008875:Middle Aged; D015508:Nasal Obstruction / Q000209:etiology / Q000628:therapy*; D009298:Nasal Polyps / Q000150:complications / Q000628:therapy*; D059085:Nasal Sprays; D000857:Olfaction Disorders / Q000209:etiology / Q000628:therapy*; D010256:Paranasal Sinuses / Q000601:surgery*; D012220:Rhinitis / Q000150:complications / Q000628:therapy*; D012852:Sinusitis / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D059085:Nasal Sprays; D000068298:Fluticasone