title: A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruli.
abstract: Major histocompatibility class I (MHCI) molecules are well known for their immunological role in mediating tissue graft rejection. Recently, these molecules were discovered to be expressed in distinct neuronal subclasses, dispelling the long-held tenet that the uninjured brain is immune-privileged. Here, we show that MHCI molecules are expressed in the main olfactory bulb (MOB) of adult animals. Furthermore, we find that mice with diminished levels of MHCI expression have enlarged MOBs containing an increased number of small, morphologically abnormal and ectopically located P2 glomeruli. These findings suggest that MHCI molecules may play an important role in the proper formation of glomeruli in the bulb.
authors.affiliation: Cell and Developmental Biology, Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Aurora, CO, USA.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Salcedo
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Cruz
authors.forename: Xuan
authors.initials: X
authors.lastname: Ly
authors.forename: Beth A
authors.initials: BA
authors.lastname: Welander
authors.forename: Kyle
authors.initials: K
authors.lastname: Hanson
authors.forename: Eugene
authors.initials: E
authors.lastname: Kronberg
authors.forename: Diego
authors.initials: D
authors.lastname: Restrepo
mesh_terms: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics* / Q000502:physiology*; D000818:Animals; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D009474:Neurons / Q000502:physiology; D009830:Olfactory Bulb / Q000033:anatomy & histology* / Q000276:immunology / Q000378:metabolism*; D009833:Olfactory Pathways / Q000502:physiology
chemical_list: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; D015395:Histocompatibility Antigens Class I; C486171:Tap1 protein, mouse
keywords: P2 glomerulus; main histocompatibility complex I; main olfactory bulb; major histocompatibility class I molecules; olfaction