title: Hepatitis C virus and human immunodeficiency virus coinfection among attendants of voluntary counseling and testing centre and HIV follow up clinics in Mekelle Hospital.
abstract: BACKGROUND
  Hepatitis C virus remains a large health care burden to the world. HIV and HCV coinfection is major global health concern worldwide. However, there is limited information on the prevalence of HCV/HIV co-infection in Ethiopia. The aim of the study was to assess the magnitude of HIV/HCV coinfection and the potential risk factors in attendants of voluntary counseling and testing centre and HIV follow up clinics of Mekelle hospital.
  
  
  METHODS
  A cross sectional seroprevalence survey of HCV infection was carried out on 300 HIV negative and positive subjects attending voluntary counseling and testing (VCT) center and HIV follow up clinics of Mekelle hospital, Ethiopia from December 2010-February 2011. Serum samples were tested for anti-HCV antibodies using immunochromatographic test.
  
  
  RESULTS
  Of the 300 study participants, 126(42%) were HIV negative and 174(58%) HIV seropositive from VCT and HIV follow up clinics, respectively. The overall anti-HCV prevalence was 18(6.0%). There were no significant differences in HCV seroprevalence among the different categories of age and sex (p> 0.05). Of the 174 persons with HIV, 16 (9.2%) cases had antibodies to HCV, where as among 126 HIV negative subjects 2 (1.58%) were HCV seropositive (p= 0.006, OR= 6.28, 95% CI= 1.42-27.82).
  
  
  CONCLUSIONS
  Accordingly, there was a significant difference in sero-positivity of HCV between HIV positive and HIV negative participants. No apparent risk factor that caused HCV infection was inferred from this study.
authors.affiliation: Department of Microbiology, Immunology and Parasitology, School of Medicine, Wollega University, P.O. Box 395, Nekemte, Ethiopia.
authors.forename: Haftom
authors.initials: H
authors.lastname: Hadush
authors.forename: Solomon
authors.initials: S
authors.lastname: Gebre-Selassie
authors.forename: Adane
authors.initials: A
authors.lastname: Mihret
mesh_terms: D015492:AIDS Serodiagnosis; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D060085:Coinfection; D003376:Counseling; D003430:Cross-Sectional Studies; D005002:Ethiopia; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000453:epidemiology*; D006761:Hospitals; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D055815:Young Adult
keywords: Hepatitis C virus; co-infection; human immunodeficiency virus; seroprevalence