title: Microscopic colitis in Uppsala health region, a population-based prospective study 2005-2009.
abstract: OBJECTIVE
  The aim of this study is to report on the incidence of microscopic colitis (MC), any possible relation with inflammatory bowel disease (IBD), concomitant drug consumption, related diseases and the clinical course of the diseases.
  
  
  METHODS
  Both new cases of IBD and MC were registered at the same time in the same geographical area. The study started in the county of Uppsala 2005-2006, and other parts of the surrounding health region were included 2007-2009. Established morphological criteria were used, i.e. a layer of subepithelial collagen band ≥ 10 μm in collagenous colitis (CC) with concomitant inflammation and at least 20 lymphocytes per 100 epithelial cells in lymphocytic colitis (LC).
  
  
  RESULTS
  The authors found 272 new cases of MC, 154 with CC and 118 with LC. The mean age-adjusted incidence was 7.0/1,000,000 for CC and 4.8/100,000 for LC. The clinical course was dominated by single episodes with diarrhea or intermittent symptoms, but 14% suffered from chronic diarrhea. In 10% of the cases, diagnosis was made in individuals without chronic watery diarrhea. Although not systematically tested, concomitant celiac disease was found in approximately 5% of the patients.
  
  
  CONCLUSIONS
  The incidence of MC in Uppsala health region is similar to other studied areas. The majority of patients had a self-limiting or easily treated condition, but 14% need a more or less continuous medication. Ten percent of the patients demonstrate other symptoms than chronic watery diarrhea. The possibility of concomitant celiac disease should be considered in new cases of MC.
authors.affiliation: Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Mari.thorn@medsci.uu.se
authors.forename: Mari
authors.initials: M
authors.lastname: Thörn
authors.forename: Daniel
authors.initials: D
authors.lastname: Sjöberg
authors.forename: Anders
authors.initials: A
authors.lastname: Ekbom
authors.forename: Tommy
authors.initials: T
authors.lastname: Holmström
authors.forename: Märit
authors.initials: M
authors.lastname: Larsson
authors.forename: Anne-Lie
authors.initials: AL
authors.lastname: Nielsen
authors.forename: Lars
authors.initials: L
authors.lastname: Holmquist
authors.forename: Ulrika
authors.initials: U
authors.lastname: Thelander
authors.forename: Alkwin
authors.initials: A
authors.lastname: Wanders
authors.forename: Anders
authors.initials: A
authors.lastname: Rönnblom
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002446:Celiac Disease / Q000150:complications / Q000453:epidemiology; D046728:Colitis, Microscopic / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D003967:Diarrhea / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012042:Registries; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents