title: Stearoyl co-A desaturase 1 as a ccRCC therapeutic target: death by stress.
abstract: There is a need for the discovery of novel therapeutic strategies to effectively treat advanced clear cell renal cell carcinoma (ccRCC). Inhibition of stearoyl-coA desaturase 1 (SCD1) in ccRCC reveals antitumor activity, independently and in synergy with mTOR inhibition. SCD1 may be a potential novel therapeutic target in treating ccRCC.
authors.affiliation: Department of Medicine and Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. wykim@med.unc.edu
authors.forename: Janet Y
authors.initials: JY
authors.lastname: Leung
authors.forename: William Y
authors.initials: WY
authors.lastname: Kim
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy*; D013230:Stearoyl-CoA Desaturase / Q000378:metabolism*
chemical_list: D013230:Stearoyl-CoA Desaturase