title: Dendritic cells in liver injury and fibrosis: shortcomings and promises.
abstract: The phenotype and function of liver dendritic cells (LDCs) are poorly understood. This Snapshot summarizes our current knowledge on LDCs in the healthy and injured liver, and their role in fibrosis progression and reversal. It also draws attention to various pitfalls in the current experimental design and conclusions based on available data.
authors.affiliation: Department of Medicine II, Saarland University Medical Center, Homburg, Germany. Electronic address: veronika.lukacs-kornek@uniklinikum-saarland.de.
authors.forename: Veronika
authors.initials: V
authors.lastname: Lukacs-Kornek
authors.forename: Detlef
authors.initials: D
authors.lastname: Schuppan
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000473:pathology* / Q000502:physiology; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D008099:Liver / Q000293:injuries* / Q000473:pathology* / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000473:pathology* / Q000503:physiopathology; D051379:Mice; D010641:Phenotype
keywords: APC; BDL; BM; Batf3; CCL(4); CD11c-DTR; CTL; DCs; DT; DTR; ECM; FA; FMS-like tyrosine kinase 3 ligand; Flt3L; GM-CSF; HL-LDC; HSC; IL-6; Id2; LDC; LL-LDC; LPS; Liver dendritic cells; MCD; MCP-1; MMP-9; MMP13; NASH; PAMPs; PBMC; TAA; TNFα; Tolerance; antigen presenting cell; basic leucine zipper transcription factor, ATF-like 3; bile duct ligation; bone marrow; carbon tetrachloride; cytotoxic T lymphocyte; dendritic cells; diphtheria toxin; diphtheria toxin receptor; extracellular matrix; fatty acid; granulocyte macrophage colony-stimulating factor; hepatic stellate cells; high-lipid liver dendritic cell; inhibitor of DNA binding 2; interleukin-6; lipopolysaccharide; liver dendritic cell; low-lipid liver dendritic cell; matrix metalloproteinase-13; matrix metalloproteinase-9; methionine choline deficient; monocyte chemotactic protein-1; non-alcoholic steatohepatitis; pDC; pathogen-associated molecular patterns; peripheral blood mononuclear cells; plasmacytoid dendritic cell; thioacetamide; tumor necrosis factor-alpha; zbtb46; zinc finger and BTB domain containing 46