title: Achievements and impacts of glycosylation reactions involved in natural product biosynthesis in prokaryotes.
abstract: Bioactive natural products, such as polyketides, flavonoids, glycopeptides, and aminoglycosides, have been used as therapeutic agents. Many of them contain structurally diverse sugar moieties attached to the aglycone core structures. Glycosyltransferases (GTs) catalyze the attachment of nucleotide-activated sugar substrates to acceptor aglycones. Because these sugar moieties are usually essential for biological activity, in vivo pathway engineering in prokaryotic hosts and in vitro enzymatic approaches coupled with GT engineering are currently being used to synthesize novel glycosylated derivatives, and some of them exhibited improved biological activities compared to the parent molecules. Therefore, harnessing the potential of diverse glycosylation reactions in prokaryotes will increase the structural diversity of natural products and the possibility to generate new bioactive products.
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea.
authors.forename: Myoung Chong
authors.initials: MC
authors.lastname: Song
authors.forename: Eunji
authors.initials: E
authors.lastname: Kim
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Ban
authors.forename: Young Ji
authors.initials: YJ
authors.lastname: Yoo
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Kim
authors.forename: Sung Ryeol
authors.initials: SR
authors.lastname: Park
authors.forename: Ramesh Prasad
authors.initials: RP
authors.lastname: Pandey
authors.forename: Jae Kyung
authors.initials: JK
authors.lastname: Sohng
authors.forename: Yeo Joon
authors.initials: YJ
authors.lastname: Yoon
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D001688:Biological Products / Q000378:metabolism*; D006031:Glycosylation; D016695:Glycosyltransferases / Q000378:metabolism
chemical_list: D001688:Biological Products; D016695:Glycosyltransferases