title: Short-time variation in serum uric acid concentrations in post-myocardial infarction patients.
abstract: BACKGROUND
  Studies on SUA temporal profile in relation to acute myocardial infarction (AMI) are controversial. The aim of this study was to evaluate the SUA level variations following myocardial infarction.
  
  
  METHODS
  We studied 222 patients more than 18 years old diagnosed with AMI. SUA was measured at baseline and on day 2 to 4 and day 5 to 8 after AMI. Within and between person variability of SUA following an AMI was estimated using intraclass correlation coefficients (ICC). The change in SUA between each assessment point was analyzed by repeated measures one-way analysis of variance. To evaluated.SUA variation post-myocardial infarction and its predictors we used generalized linear mixed-effects models.
  
  
  RESULTS
  The mean plasma concentration of SUA was lower at baseline (58.5 +/- 18.9 mg/L). The ICC across the three time points was 0.75 (95% CI 0.70 - 0.80). SUA levels increased 1.33 mg/L per day after AMI (2.3 mg/L/day in women and 1.0 mg/L/day in men). Normouricemic patients had a 1.6 fold increase risk to change to hyperuricemic status per day after AMI (OR = 1.60, 95% CI: 1.27 - 2.00).
  
  
  CONCLUSIONS
  Serum uric acid concentration is relatively stable over an eight-day post-myocardial infarction period. However, even a small increase of SUA per day after AMI is associated with a high probability of changing the classification of hyperuricemic status.
authors.affiliation: Institute of Public Health, University of Porto, Portugal. pierre_3.14r@hotmail.com
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Gonçalves
authors.forename: Milton
authors.initials: M
authors.lastname: Severo
authors.forename: Inês
authors.initials: I
authors.lastname: Rangel
authors.forename: Carla
authors.initials: C
authors.lastname: de Sousa
authors.forename: Maria Júlia
authors.initials: MJ
authors.lastname: Maciel
authors.forename: Carla
authors.initials: C
authors.lastname: Lopes
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid