title: Autologous fat transfer with in-situ mediation (AIM): a novel and compliant method of adult mesenchymal stem cell therapy.
abstract: In an attempt to engineer a regulatory compliant form of cell assisted lipotransfer in the U.S., the authors developed Autologous Fat Transfer with In-situ Mediation (AIM) for reconstruction of a refractory surgical scar.
  
  
  
  This method incorporates use of accepted standard procedures like autologous fat grafting and intradermal injection of NB6 collagenase to release adipose stem cells from a naturally occurring high concentration stromal vascular fraction (SVF) fat graft. To prevent off-target effects of collagenase, a hyaluronic acid and serum deactivation barrier is placed circumferentially around the operative site.
  
  
  
  This novel protocol was well tolerated by the patient and improved scar appearance, mobility and texture. Deepest scar contour defect correction was 80% and 77% at 4 and 12 weeks respectively.
  
  
  
  AIM appears to be a practical and viable option for scar reconstruction requiring small to moderate volume correction.
authors.forename: Allan Y
authors.initials: AY
authors.lastname: Wu
authors.forename: David M
authors.initials: DM
authors.lastname: Morrow
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D053687:Adult Stem Cells / Q000166:cytology / Q000637:transplantation*; D019983:Guideline Adherence; D006801:Humans; D021621:Imaging, Three-Dimensional; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D014182:Transplantation, Autologous; D014481:United States; D014486:United States Food and Drug Administration