title: Copper/TEMPO catalysed synthesis of nitriles from aldehydes or alcohols using aqueous ammonia and with air as the oxidant.
abstract: Copper/TEMPO catalysts can be used to prepare nitriles from aldehydes or alcohols using aqueous ammonia. Readily accessible methods were developed that enable standard glassware to be used with air as the source of O2. It was further shown that, at higher temperatures in a pressurised reactor under limiting oxygen conditions (8% O2), catalyst loadings of 1 mol% could be employed.
authors.affiliation: School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast, BT9 5AG, UK.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Dornan
authors.forename: Qun
authors.initials: Q
authors.lastname: Cao
authors.forename: James C A
authors.initials: JC
authors.lastname: Flanagan
authors.forename: James J
authors.initials: JJ
authors.lastname: Crawford
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Cook
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Muldoon
mesh_terms: D000388:Air; D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D000641:Ammonia / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003497:Cyclic N-Oxides / Q000737:chemistry*; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D000438:Alcohols; D000447:Aldehydes; D003497:Cyclic N-Oxides; D009570:Nitriles; D014867:Water; D000641:Ammonia; D003300:Copper; C003959:TEMPO