title: Alkaloids from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013.
abstract: Two new benzodiazepine alkaloids, circumdatins K and L (1, 2), two new prenylated indole alkaloids, 5-chlorosclerotiamide (3) and 10-epi-sclerotiamide (4), and one novel amide, aspergilliamide B (5), together with six known alkaloids were isolated from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013. Their structures were elucidated by extensive spectroscopic analysis. All of the compounds were tested for cytotoxicity toward human carcinoma A549, HL-60, K562, and MCF-7 cell lines.
authors.affiliation: Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Material Medical/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, People's Republic of China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Peng
authors.forename: Xiao-Yong
authors.initials: XY
authors.lastname: Zhang
authors.forename: Zheng-Chao
authors.initials: ZC
authors.lastname: Tu
authors.forename: Xin-Ya
authors.initials: XY
authors.lastname: Xu
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Qi
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D018922:HL-60 Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007212:Indolizines; D020014:K562 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D013141:Spiro Compounds
chemical_list: D000470:Alkaloids; D000577:Amides; D026121:Indole Alkaloids; D007212:Indolizines; D013141:Spiro Compounds; C582939:aspergilliamide B; C582937:circumdatin K; C582938:circumdatin L; C103459:sclerotiamide