title: Synthesis and hypoglycemic activity of some new theophylline derivatives.
abstract: Thirty-one new theophylline derivatives have been synthesized and evaluated for their hypoglycemic activity. Compounds 24 (56% reduction) and 31 (57% reduction) showed better hypoglycemic activity than the standard drug glibenclamide which showed 52% reduction in serum glucose level. Compound 27 remarkably reduced serum glucose level by 53%. Ten compounds showed varying degrees of hypoglycemic activity ranging from 20 to 37% reduction in serum glucose level compared to the standard drug. The aromatic amide functionality is the common feature of these theophylline hypoglycemic derivatives. However, anthranilamide and or aliphatic amides proved to be the least active compounds in the present series.
authors.affiliation: Department of Pharmaceutical Chemistry and.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Alafeefy
authors.forename: Saleh I
authors.initials: SI
authors.lastname: Alqasoumi
authors.forename: Sami G
authors.initials: SG
authors.lastname: Abdel Hamid
authors.forename: Kamal E H
authors.initials: KE
authors.lastname: El-Tahir
authors.forename: Menshawy
authors.initials: M
authors.lastname: Mohamed
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Zain
authors.forename: Amani S
authors.initials: AS
authors.lastname: Awaad
mesh_terms: D000577:Amides / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D013329:Structure-Activity Relationship; D013806:Theophylline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000577:Amides; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013311:Streptozocin; D013806:Theophylline
keywords: Hypoglycemic; isoindoline; synthesis; theophylline