title: Water dispersal and functionalization of hydrophobic iron oxide nanoparticles with lipid-modified poly(amidoamine) dendrimers.
abstract: A novel and facile method for water dispersal of hydrophobic iron oxide nanoparticles based on the amphiphilic PAMAM-C12 dendrimer is described. Stable and highly concentrated water dispersions of multifunctional magnetic nanoparticles were obtained with this single-step approach, and showed interesting relaxometric properties for MRI applications. Importantly, this method does not require substitution of the native hydrophobic capping under nonmild reaction conditions, thus preserving the structural and magnetic properties of the nanoparticles, and extending the possibility of conjugation with thermally labile groups.
authors.affiliation: Istituto Italiano di Tecnologia, Center for Nanotechnology Innovation @NEST, Piazza San Silvestro 12, 56127 Pisa, Italy. adriano.boni@iit.it
authors.forename: Adriano
authors.initials: A
authors.lastname: Boni
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Albertazzi
authors.forename: Claudia
authors.initials: C
authors.lastname: Innocenti
authors.forename: Mauro
authors.initials: M
authors.lastname: Gemmi
authors.forename: Angelo
authors.initials: A
authors.lastname: Bifone
mesh_terms: D050091:Dendrimers / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D059346:Magnets; D046529:Microscopy, Electron, Transmission; D010420:Pentanes / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C104700:PAMAM Starburst; D010420:Pentanes; D013501:Surface-Active Agents; D014867:Water; C000499:ferric oxide; C033353:pentane