title: Non-Hodgkin's lymphoma: a cause of paraneoplastic cholestasis.
abstract: We describe a 79-year-old gentleman with a longstanding history of chronic lymphocytic leukaemia who presented with subacute onset of cholestatic jaundice. Comprehensive review of the patient's data and medications failed to reveal any obvious causes. Exhaustive testing including abdominal CT and magnetic resonance cholangiopancreatography failed to reveal any obstruction. A liver biopsy demonstrated scattered non-caseating granulomas. The patient was diagnosed with granulomatous hepatitis and treated with oral steroids and eventually improved. It was thought to be due to paraneoplastic cholestasis as an extrahepatic manifestation of non-Hodgkin's lymphoma.
authors.affiliation: Henry Ford Hospital, Detroit, Michigan, USA. zaid_md@live.com
authors.forename: Zaid
authors.initials: Z
authors.lastname: Alirhayim
authors.forename: Herman
authors.initials: H
authors.lastname: Dyal
authors.forename: Abdulqader
authors.initials: A
authors.lastname: Alarhayem
authors.forename: Vijayalakshmi
authors.initials: V
authors.lastname: Donthireddy
mesh_terms: D000368:Aged; D001706:Biopsy; D002779:Cholestasis / Q000175:diagnosis* / Q000209:etiology; D006099:Granuloma / Q000175:diagnosis* / Q000209:etiology; D006505:Hepatitis / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D041781:Jaundice, Obstructive / Q000175:diagnosis / Q000209:etiology; D007945:Leukemia, Lymphoid / Q000150:complications / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000473:pathology*; D008297:Male; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000175:diagnosis* / Q000473:pathology