title: Endoscopic sleeve gastroplasty: a potential endoscopic alternative to surgical sleeve gastrectomy for treatment of obesity.
abstract: BACKGROUND
  Obesity and its associated conditions, including type 2 diabetes and cardiovascular disease, have reached epidemic proportions. High-efficacy, high-risk surgical approaches are unlikely to meet the increasing burden of disease. Emerging endoscopic technologies have opened the door for endoscopic approaches to reproduce many of the benefits of GI weight loss surgery and thereby contribute to the effective treatment of obesity and its associated disorders.
  
  
  OBJECTIVE
  To demonstrate the technical feasibility of transoral endoscopic gastric volume reduction with an endoscopic suturing device in a fashion similar to sleeve gastrectomy for the treatment of obesity.
  
  
  METHODS
  Single-center, pilot feasibility study.
  
  
  METHODS
  Four human subjects with obesity.
  
  
  METHODS
  Transoral sleeve gastroplasty.
  
  
  METHODS
  Technical feasibility.
  
  
  RESULTS
  We successfully used an endoscopic free-hand suturing system in 4 subjects, thus demonstrating the technical feasibility of a novel technique to mimic the anatomic manipulations created by surgical sleeve gastrectomy endoscopically.
  
  
  CONCLUSIONS
  Pilot feasibility study with small number of subjects.
  
  
  CONCLUSIONS
  Endoscopic sleeve gastroplasty for treatment of obesity is feasible.
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Barham K
authors.initials: BK
authors.lastname: Abu Dayyeh
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Rajan
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Gostout
mesh_terms: D000328:Adult; D016099:Endoscopy, Gastrointestinal / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D015391:Gastroplasty / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000601:surgery*; D061646:Operative Time; D009929:Organ Size; D010149:Postoperative Pain / Q000209:etiology; D013270:Stomach / Q000033:anatomy & histology* / Q000601:surgery; D013536:Suture Techniques / Q000009:adverse effects / Q000295:instrumentation
keywords: GE; GI weight loss surgery; GIWLS; SD; gastroesophageal; standard deviation