title: Acute generalized exanthematous pustulosis during antituberculosis therapy.
abstract: Acute generalized exanthematous pustulosis (AGEP) is a significant adverse cutaneous reaction most often induced by drugs and by acute infections. Its clinical hallmark is the sudden onset of multiple, disseminated, non-follicular, sterile pustules on an erythematous background usually arising in intertriginous folds, associated with fever, massive neutrophilia and sometimes eosinophilia. Antitubercular therapy is described as an uncommon cause of AGEP. We report the onset of disseminated non-follicular sterile pustules on an erythematous background in a 68-year-old man receiving a combination of isoniazid, pyrazinamide and rifampicin that may have been the etiologic agents. A thorough history, including a medication history, with clinicopathologic correlation is crucial in patients presenting with acute diffuse pustular lesions.
authors.affiliation: Department of Dermatology, University of Rome Sapienza, Rome, Italy. carmencantisanister@gmail.com
authors.forename: C
authors.initials: C
authors.lastname: Cantisani
authors.forename: A
authors.initials: A
authors.lastname: Paradisi
authors.forename: A G
authors.initials: AG
authors.lastname: Richetta
authors.forename: C
authors.initials: C
authors.lastname: Mattozzi
authors.forename: S
authors.initials: S
authors.lastname: Calvieri
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000209:etiology*; D000368:Aged; D000995:Antitubercular Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male
chemical_list: D000995:Antitubercular Agents