title: Expression of bmi-1 protein in cervical, breast and ovarian cancer.
abstract: B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-l) is a member of polycomb group, which participates in axial patterning, hematopoiesis, cell cycle regulation, and senescence. Overexpression of Bmi-1 has been reported in various human cancers and proved to be associated with poor survival. DISSUCION: Bmi-I is expressed by various tumors and therefore may contribute to malignant transformation. Bmi-I not only can lead mammary epithelial cells to senescence and immortalization, but also plays a key role in breast cancer. A significant correlation was observed between Bmi-1 expression and axillary lymph node metastases in lymph-ductal breast cancer. Bmi-1 is expressed in cervical cancer and correlated with a poorer prognosis, suggesting that this protein participates in the development and progress of cervical cancer. Regarding ovarian cancer, the results of several immunohistochemical studies revealed overexpression of Bmi-1, especially in poorly differentiated ovarian carcinoma. There is a strong correlation between histological grade, clinical stage and its expression.
  
  
  CONCLUSIONS
  Human genes of polycomb group correlated with various hematological and epithelial cancers identify new mechanisms of malignant transformation and pave the way for developing new cancer treatments and identify new diagnostic markers. Bmi-1 and its expression in tissues taken from patients with cervical, breast and ovarian cancer could be a marker for diagnosis and prognosis, and not least a potential target of antitumor therapy.
authors.affiliation: University of Medicine and Pharmacy Grigore T Popa Iasi, Faculty of Medicine.
authors.forename: Mihaela-Madalina
authors.initials: MM
authors.lastname: Gavrilescu
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Todosi
authors.forename: Maria-Gabriela
authors.initials: MG
authors.lastname: Aniţei
authors.forename: B
authors.initials: B
authors.lastname: Filip
authors.forename: V
authors.initials: V
authors.lastname: Scripcariu
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D063150:Polycomb Repressive Complex 1 / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
chemical_list: C069077:BMI1 protein, human; D014408:Biomarkers, Tumor; D063150:Polycomb Repressive Complex 1