title: Immunomodulating and anti-allergic effects of Negroamaro and Koshu Vitis vinifera fermented grape marc (FGM).
abstract: Polyphenols contained in FGM from Negroamaro (N) and Koshu (K) Vitis vinifera have been shown to exhibit several immunomodulating activities. For instance, mice affected by experimental colitis when administered with K-FGM showed an attenuation of the inflammatory process. In murine asthma, K-FGM reduced IgE production and eosinophil number in bronchial alveolar lavage fluid. In vitro, both N- and K-FGM were able to induce T regulatory cells in terms of Foxp-3 molecule expression and release of interleukin-10. In another set of experiments both N- and K-FGM were able to balance rate of proliferation/apoptosis/necrosis of normal human peripheral lymphocytes, thus indicating the property of these compounds to maintain immune homeostatic mechanisms in the host. On the other hand, N- and K-FGM inhibited human basophil degranulation, thus, confirming our previous results obtained with rat basophilic leukemia cells. Finally, N- and K-FGM also decreased oxidative burst of human polymorphonuclear cells and monocytes.Taken together, these findings imply the potential clinical usefulness of FGM administration in inflammatory/allergic conditions, such as chronic asthma.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Marzulli
authors.forename: Thea
authors.initials: T
authors.lastname: Magrone
authors.forename: Luisa
authors.initials: L
authors.lastname: Vonghia
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kaneko
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takimoto
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kumazawa
authors.affiliation: Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, Bari, Italy, Piazza G. Cesare, 11-70124 Bari, Italy. jirillo@midim.uniba.it.
authors.forename: Emilio
authors.initials: E
authors.lastname: Jirillo
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001249:Asthma / Q000188:drug therapy / Q000276:immunology; D005285:Fermentation; D006801:Humans; D007155:Immunologic Factors / Q000302:isolation & purification / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D051379:Mice; D059808:Polyphenols / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D027843:Vitis / Q000737:chemistry*
chemical_list: D018926:Anti-Allergic Agents; D007155:Immunologic Factors; D059808:Polyphenols