title: Endothelial keratoplasty: evolution and horizons.
abstract: Endothelial keratoplasty has been adopted by corneal surgeons worldwide as an alternative to penetrating keratoplasty (PK) in the treatment of corneal endothelial disorders. Since the first surgeries in 1998, different surgical techniques have been used to replace the diseased endothelium. Compared with penetrating keratoplasty, all these techniques may provide faster and better visual rehabilitation with minimal change in refractive power of the transplanted cornea, minimal induced astigmatism, elimination of suture-induced complications and late wound dehiscence, and a reduced demand for postoperative care. Translational research involving cell-based therapy is the next step in work on endothelial keratoplasty. The present review updates information on comparisons among different techniques and predicts the direction of future treatment.
authors.affiliation: Cornea Section, Ophthalmology Department, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP, Brazil. ggrottone@gmail.com
authors.forename: Gustavo Teixeira
authors.initials: GT
authors.lastname: Grottone
authors.forename: Nicolas Cesário
authors.initials: NC
authors.lastname: Pereira
authors.forename: José Álvaro Pereira
authors.initials: JÁ
authors.lastname: Gomes
mesh_terms: D003886:Descemet Membrane / Q000601:surgery*; D057111:Descemet Stripping Endothelial Keratoplasty / Q000379:methods*; D004728:Endothelium, Corneal / Q000637:transplantation*; D006084:Graft Rejection; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000009:adverse effects / Q000379:methods*; D011182:Postoperative Care; D013536:Suture Techniques / Q000009:adverse effects; D014792:Visual Acuity