title: Enhanced antitumor effect of curcumin liposomes with local hyperthermia in the LL/2 model.
abstract: Curcumin previously was proven to inhibit angiogenesis and display potent antitumor activity in vivo and in vitro. In the present study, we investigated whether a combination curcumin with hyperthermia would have a synergistic antitumor effect in the LL/2 model. The results indicated that combination therapy significantly inhibited cell proliferation of MS-1 and LL/2 in vitro. LL/2 experiment model also demonstrated that the combination therapy inhibited tumor growth and prolonged the life span in vivo. Furthermore, combination therapy reduced angiogenesis and increased tumor apoptosis. Our findings suggest that the combination therapy exerted synergistic antitumor effects, providing a new perspective fpr clinical tumor therapy.
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.
authors.forename: Jian-Cai
authors.initials: JC
authors.lastname: Tang
authors.forename: Hua-Shan
authors.initials: HS
authors.lastname: Shi
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Wan
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Wang
authors.forename: Yu-Quan
authors.initials: YQ
authors.lastname: Wei
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis; D015153:Blotting, Western; D018827:Carcinoma, Lewis Lung / Q000098:blood supply / Q000473:pathology / Q000517:prevention & control*; D049109:Cell Proliferation; D003131:Combined Modality Therapy; D003474:Curcumin / Q000627:therapeutic use*; D005260:Female; D005455:Fluorescent Antibody Technique; D006979:Hyperthermia, Induced; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic / Q000517:prevention & control*
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D003474:Curcumin