title: [Molecular mechanisms of renal extracellular matrix degradation and interventional effects of Chinese herbal medicine].
abstract: The reduction of extracellular matrix (ECM) degradation in kidney is taken as the morphological features and pathological base in renal injury in chronic kidney disease (CKD). ECM degradation is controlled by the catabolic enzyme systems in glomerulus and renal interstitium, in which matrix metalloproteinases (MMPs) play a key role. The expression and activity of MMPs are regulated by the classical pathway, such as the genic transcription, the activation of zymogen, and the specific inhibitor. The previous studies showed that, Uremic Clearance granule, as a representation, and other prescriptions of Chinese herbal medicine, as well as some extracts from Chinese herbal medicine could intervene the pathway of ECM degradation through promoting the degradation of ECM components, affecting the expression of catabolic enzymes, regulating the genetic transcription of MMPs, and inhibiting the relative signaling transduction of MMPs.
authors.affiliation: Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China. wei.qingxue@163.com
authors.forename: Qing-Xue
authors.initials: QX
authors.lastname: Wei
authors.forename: Yi-Gang
authors.initials: YG
authors.lastname: Wan
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.forename: Hao-Li
authors.initials: HL
authors.lastname: Chen
authors.forename: Xian-Jie
authors.initials: XJ
authors.lastname: Meng
authors.forename: Jian
authors.initials: J
authors.lastname: Yao
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005109:Extracellular Matrix / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000166:cytology* / Q000187:drug effects / Q000473:pathology; D020782:Matrix Metalloproteinases / Q000378:metabolism; D059748:Proteolysis / Q000187:drug effects*; D051785:Smad Proteins / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D051785:Smad Proteins; D020782:Matrix Metalloproteinases