title: Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches.
abstract: UK Biobank is a prospective cohort study with 500,000 participants aged 40 to 69. Recently an enhanced imaging study received funding. Cardiovascular magnetic resonance (CMR) will be part of a multi-organ, multi-modality imaging visit in 3-4 dedicated UK Biobank imaging centres that will acquire and store imaging data from 100,000 participants (subject to successful piloting). In each of UK Biobank's dedicated bespoke imaging centres, it is proposed that 15-20 participants will undergo a 2 to 3 hour visit per day, seven days a week over a period of 5-6 years. The imaging modalities will include brain MRI at 3 Tesla, CMR and abdominal MRI at 1.5 Tesla, carotid ultrasound and DEXA scans using carefully selected protocols. We reviewed the rationale, challenges and proposed approaches for concise phenotyping using CMR on such a large scale. Here, we discuss the benefits of this imaging study and review existing and planned population based cardiovascular imaging in prospective cohort studies. We will evaluate the CMR protocol, feasibility, process optimisation and costs. Procedures for incidental findings, quality control and data processing and analysis are also presented. As is the case for all other data in the UK Biobank resource, this database of images and related information will be made available through UK Biobank's Access Procedures to researchers (irrespective of their country of origin and whether they are academic or commercial) for health-related research that is in the public interest.
authors.affiliation: Centre Lead for Advanced Cardiovascular Imaging, William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts, The London Chest Hospital, Bonner Road, London E2 9JX, UK. s.e.petersen@qmul.ac.uk
authors.forename: Steffen E
authors.initials: SE
authors.lastname: Petersen
authors.forename: Paul M
authors.initials: PM
authors.lastname: Matthews
authors.forename: Fabian
authors.initials: F
authors.lastname: Bamberg
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
authors.forename: Jane M
authors.initials: JM
authors.lastname: Francis
authors.forename: Matthias G
authors.initials: MG
authors.lastname: Friedrich
authors.forename: Paul
authors.initials: P
authors.lastname: Leeson
authors.forename: Eike
authors.initials: E
authors.lastname: Nagel
authors.forename: Sven
authors.initials: S
authors.lastname: Plein
authors.forename: Frank E
authors.initials: FE
authors.lastname: Rademakers
authors.forename: Alistair A
authors.initials: AA
authors.lastname: Young
authors.forename: Steve
authors.initials: S
authors.lastname: Garratt
authors.forename: Tim
authors.initials: T
authors.lastname: Peakman
authors.forename: Jonathan
authors.initials: J
authors.lastname: Sellors
authors.forename: Rory
authors.initials: R
authors.lastname: Collins
authors.forename: Stefan
authors.initials: S
authors.lastname: Neubauer
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011159:Population Surveillance; D011446:Prospective Studies; D012042:Registries; D006113:United Kingdom / Q000453:epidemiology