title: Neu2000 potentiates a kainate response in mouse cortical neurons.
abstract: Neu2000, acting as an antioxidant with N-methyl-d-aspartate-receptor antagonism, demonstrates excellent protection against ischemic insults in rodents. In this study, we report that Neu2000 also dramatically enhances the activity of kainate (KA) receptors. Neu2000 non-competitively and reversibly potentiated KA-evoked responses in a voltage-independent manner, mainly by increasing the open probability of KA receptor channels.
authors.affiliation: Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Korea.
authors.forename: Jihyun
authors.initials: J
authors.lastname: Noh
authors.forename: Jun-mo
authors.initials: JM
authors.lastname: Chung
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002540:Cerebral Cortex; D005071:Evoked Potentials / Q000187:drug effects; D005464:Fluorobenzenes / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D009474:Neurons / Q000378:metabolism*; D018092:Kainic Acid Receptors / Q000378:metabolism* / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D012459:Salicylates / Q000494:pharmacology*; D013268:Stimulation, Chemical; D062368:meta-Aminobenzoates / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D005464:Fluorobenzenes; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate; D012459:Salicylates; D062368:meta-Aminobenzoates; C519903:2-hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)benzoic acid