title: Yolk-type Au@Fe3O4@C nanospheres for drug delivery, MRI and two-photon fluorescence imaging.
abstract: Nearly monodispersed yolk-type Au@Fe3O4@C nanospheres with hollow cores of 50 nm in diameter were prepared through coating Au@SiO2 nanoparticles with Fe3O4@C double layers, followed by dissolving SiO2. The cytotoxicity of the nanospheres was evaluated by MTT assay, demonstrating a high biocompatibility. The yolk-type nanospheres show a high DOX loading content of 1237 mg g(-1). The coexistence of Fe3O4 and Au also makes the nanospheres as dual probes for MR imaging with a specific relaxivity (r2*) of 384.38 mM(-1) s(-1) and optical fluorescence imaging using a near-infrared (NIR) excitation.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale and Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, 230026, PR China.
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Zhou
authors.forename: Hai-Bao
authors.initials: HB
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Gong
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Sun
authors.forename: Kai
authors.initials: K
authors.lastname: Cheng
authors.forename: Xiang-kai
authors.initials: XK
authors.lastname: Kong
authors.forename: Zhen
authors.initials: Z
authors.lastname: Guo
authors.forename: Qian-Wang
authors.initials: QW
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002244:Carbon / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D005290:Ferric Compounds / Q000737:chemistry / Q000494:pharmacology*; D006046:Gold / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D036641:Microscopy, Fluorescence, Multiphoton; D054118:Nanospheres / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D005290:Ferric Compounds; C000499:ferric oxide; D002244:Carbon; D006046:Gold