title: Dual time point 2-deoxy-2-[18F]fluoro-D-glucose PET/CT: nodal staging in locally advanced breast cancer.
abstract: OBJECTIVE
  To assess dual time point 2-deoxy-2-[(18)F]fluoro-D-glucose (18)(F)FDG PET-CT accuracy in nodal staging and in detection of extra-axillary involvement.
  
  
  METHODS
  Dual time point [(18)F] FDG PET/CT scan was performed in 75 patients. Visual and semiquantitative assessment of lymph nodes was performed. Semiquantitative measurement of SUV and ROC-analysis were carried out to calculate SUV(max) cut-off value with the best diagnostic performance. Axillary and extra-axillary lymph node chains were evaluated.
  
  
  RESULTS
  Sensitivity and specificity of visual assessment was 87.3% and 75%, respectively. SUV(max) values with the best sensitivity were 0.90 and 0.95 for early and delayed PET, respectively. SUV(max) values with the best specificity were 1.95 and 2.75, respectively. Extra-axillary lymph node involvement was detected in 26.7%.
  
  
  CONCLUSIONS
  FDG PET/CT detected extra-axillary lymph node involvement in one-fourth of the patients. Semiquantitative lymph node analysis did not show any advantage over the visual evaluation.
authors.affiliation: Nuclear Medicine Department, University General Hospital, Ciudad Real, Spain. Electronic address: angarvice@yahoo.es.
authors.forename: A M
authors.initials: AM
authors.lastname: García Vicente
authors.affiliation: Nuclear Medicine Department, University General Hospital, Ciudad Real, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Soriano Castrejón
authors.affiliation: Oncology Department, Virgen de la Salud Hospital, Toledo, Spain.
authors.forename: M Á
authors.initials: MÁ
authors.lastname: Cruz Mora
authors.affiliation: Oncology Department, Virgen de la Luz Hospital, Cuenca, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Ortega Ruiperez
authors.affiliation: Oncology Department, La Mancha Centro Hospital, Alcázar de San Juan, Ciudad Real, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Espinosa Aunión
authors.affiliation: Investigation Unit, University General Hospital, Ciudad Real, Spain.
authors.forename: A
authors.initials: A
authors.lastname: León Martín
authors.affiliation: Oncology Department, Nuestra Sra. del Prado Hospital, Talavera de la Reina, Toledo, Spain.
authors.forename: A
authors.initials: A
authors.lastname: González Ageitos
authors.affiliation: Nuclear Medicine Department, University General Hospital, Ciudad Real, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Van Gómez López
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D009367:Neoplasm Staging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy; D013909:Thorax; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: (18)(F)FDG PET/CT; Cáncer de mama localmente avanzado; Dual time point PET; Estadificación ganglionar; Locally advanced breast cancer; Lymph node staging; PET en doble fase; [(18)F] FDG PET-TC