title: Inherited disorders of platelets: membrane glycoprotein disorders.
abstract: Platelet membrane glycoproteins play a key role in hemostasis and thrombosis. Although disorders of platelet membrane glycoproteins are rare, their effects on the lives of those affected are very important. Severe deficiencies manifest themselves early during childhood with mucocutaneous bleeding. Mild deficiencies may not be diagnosed until adulthood or until the hemostatic system is stressed by surgery or trauma. The diagnosis of these disorders requires detailed laboratory investigation. Management of bleeding in patients with inherited platelet disorders requires both preventive measures and the treatment of individual bleeding episodes according to severity. The study of platelet membrane disorders also has yielded important insights into the functions of affected proteins, information that has produced some of the most successful antithrombotic drugs currently in use.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Hematology and Oncology Clinic, Avrupa Florence Nightingale Hospital, Sishane, Istanbul, Turkey. rkucukkaya@hotmail.com
authors.forename: Reyhan
authors.initials: R
authors.lastname: Diz-Kücükkaya
authors.forename: José A
authors.initials: JA
authors.lastname: López
mesh_terms: D001791:Blood Platelet Disorders / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D006801:Humans; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics; D010980:Platelet Membrane Glycoproteins / Q000235:genetics*; D038981:Receptors, Collagen / Q000235:genetics
chemical_list: D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D038981:Receptors, Collagen