title: [Change in the blood cytokine spectrum in patients with pulmonary sarcoidosis].
abstract: OBJECTIVE
  To assess cytokine spectrum changes in different types of pulmonary sarcoidosis (PS).
  
  
  METHODS
  Twenty-seven PS patients without signs of pulmonary fibrosis and 14 patients with sarcoidosis complicated by pulmonary fibrosis were examined. Baseline serum Th1 and Th2 cytokine concentrations were studied. A control group comprised 30 healthy donors.
  
  
  RESULTS
  A higher interleukin (IL)-4/IL-2 ratio was found in the peripheral blood of the patients with pulmonary fibrosis-complicated sarcoidosis than in the other patients (326.4 +/- 122.6 and 88.2 +/- 28.6%, respectively; p = 0.002). The sarcoidosis patients with signs of pulmonary fibrosis and no symptoms of disease inflammatory activity had elevated blood IL-1 levels whereas an IL-1 receptor antagonist was decreased.
  
  
  CONCLUSIONS
  In the patients with PS, the development and progression of pulmonary fibrosis occur with a shift in the Th1/Th2 balance towards Th2, which manifests itself as a higher IL-4/IL-2 ratio in the peripheral blood. At the same time, the signs of systemic inflammatory activity remain.
authors.forename: S A
authors.initials: SA
authors.lastname: Terpigorev
authors.forename: A A
authors.initials: AA
authors.lastname: Novikov
authors.forename: B A
authors.initials: BA
authors.lastname: El-Zein
authors.forename: E H
authors.initials: EH
authors.lastname: Aleksandrova
authors.forename: V V
authors.initials: VV
authors.lastname: Iazdovskiĭ
authors.forename: O V
authors.initials: OV
authors.lastname: Moskalets
authors.forename: F N
authors.initials: FN
authors.lastname: Paleev
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000097:blood / Q000453:epidemiology / Q000473:pathology; D017565:Sarcoidosis, Pulmonary / Q000097:blood* / Q000453:epidemiology / Q000473:pathology; D018417:Th1 Cells / Q000276:immunology / Q000473:pathology; D018418:Th2 Cells / Q000276:immunology / Q000473:pathology
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D007376:Interleukin-2; D015847:Interleukin-4