title: A study of controlled uptake and release of anthocyanins by oxidized starch microgels.
abstract: Anthocyanins are well-known antioxidants, but they are sensitive to environmental conditions. Herein we used oxidized starch microgel to prevent their early degradation and deliver them to the target place. The aim of this study was to investigate the uptake and the release ability of anthocyanins by the oxidized starch microgels and measure their in vitro gastrointestinal release. The gels were made of oxidized potato starch polymers, which were chemically cross-linked by sodium trimetaphosphate (STMP). In this study, the uptake and release behaviors of anthocyanins by starch microgel were investigated under various pH and salt concentrations. The microgel of high degree of oxidation and high cross-link density had a high uptake capacity for anthocyanins at low pH and salt concentration; 62 mg anthocyanins had been absorbed per gram of dry DO100% (degree of oxidation 100%) microgel at pH 3 with ionic strength 0.05M. The in vitro study of the release was investigated under stimulated gastrointestinal fluid. The anthocyanins were identified and quantified by UV/vis detection. The results indicated that the oxidized starch microgels had a potential for being a carrier system for protecting anthocyanins from degradation in the upper gastric tract and for delivering them to the intestine. This paper provides a good reference for an intestinal-targeted delivery system of vulnerable functional ingredients by oxidized starch microgel.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology , North Third Ring Road 15, 100029 Beijing, China.
authors.forename: Zhaoran
authors.initials: Z
authors.lastname: Wang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.forename: Xiulan
authors.initials: X
authors.lastname: Xin
authors.forename: Qipeng
authors.initials: Q
authors.lastname: Yuan
mesh_terms: D000872:Anthocyanins / Q000032:analysis / Q000737:chemistry* / Q000191:economics / Q000378:metabolism; D000975:Antioxidants / Q000032:analysis / Q000737:chemistry* / Q000191:economics / Q000378:metabolism; D029798:Blueberry Plants / Q000737:chemistry; D002681:China; D004058:Diffusion; D004063:Digestion; D005527:Food, Fortified / Q000032:analysis* / Q000191:economics; D005525:Food-Processing Industry; D005638:Fruit / Q000737:chemistry; D041981:Gastrointestinal Tract / Q000378:metabolism*; D005782:Gels; D006801:Humans; D007220:Industrial Waste / Q000032:analysis / Q000191:economics; D007700:Kinetics; D008954:Models, Biological; D010084:Oxidation-Reduction; D012995:Solubility; D013213:Starch / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D005782:Gels; D007220:Industrial Waste; D013213:Starch