title: A novel modified carbon paste electrode based on NiO/CNTs nanocomposite and (9, 10-dihydro-9, 10-ethanoanthracene-11, 12-dicarboximido)-4-ethylbenzene-1, 2-diol as a mediator for simultaneous determination of cysteamine, nicotinamide adenine dinucleotide and folic acid.
abstract: A carbon paste electrode (CPE) modified with (9, 10-dihydro-9, 10-ethanoanthracene-11, 12-dicarboximido)-4-ethylbenzene-1, 2-diol (DEDE) and NiO/CNTs nanocomposite was used for the sensitive voltammetric determination of cysteamine (CA), nicotinamide adenine dinucleotide (NADH) and folic acid (FA) for the first time. The synthesized materials were characterized with different methods such as XRD, cyclic voltammetry, electrochemical impedance spectroscopy (EIS) and square wave voltammetry (SWV). The modified electrode exhibited a potent and persistent electron mediating behavior followed by well-separated oxidation peaks of CA, NADH and FA. The peak currents were linearly dependent on CA, NADH and FA concentrations using square wave voltammetry (SWV) method in the ranges of 0.01-250, 1.0-500, and 3.0-550 µmol L⁻¹, with detection limits of 0.007, 0.6, and 0.9 µmol L⁻¹, respectively. The modified electrode was used for the determination of CA, NADH and FA in biological and pharmaceutical samples.
authors.affiliation: Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran. h.karimi.maleh@gmail.com
authors.forename: Hassan
authors.initials: H
authors.lastname: Karimi-Maleh
authors.forename: Pourya
authors.initials: P
authors.lastname: Biparva
authors.forename: Mehdi
authors.initials: M
authors.lastname: Hatami
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods; D002244:Carbon / Q000737:chemistry; D003543:Cysteamine / Q000032:analysis* / Q000652:urine; D055664:Electrochemical Techniques / Q000379:methods; D004566:Electrodes; D005492:Folic Acid / Q000032:analysis* / Q000652:urine; D006801:Humans; D057230:Limit of Detection; D009243:NAD / Q000032:analysis* / Q000652:urine; D053761:Nanocomposites / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry
chemical_list: D001555:Benzene Derivatives; D037742:Nanotubes, Carbon; D004364:Pharmaceutical Preparations; D009243:NAD; D003543:Cysteamine; D002244:Carbon; D009532:Nickel; D005492:Folic Acid; C028007:nickel monoxide; C004912:ethylbenzene