title: Glyburide as treatment option for gestational diabetes mellitus.
abstract: OBJECTIVE
  The aim of this study was to assess the efficacy of glyburide in the treatment of gestational diabetes mellitus and to compare the maternal and fetal outcome between two groups treated either with insulin or glyburide.
  
  
  METHODS
  Women with gestational diabetes not responding to diet control were randomized into two groups: (i) the control group receiving insulin (n = 32); and (ii) the study group receiving glyburide (n = 32). Primary outcome was assessed in terms of achievement of glycemic control and secondary outcome was assessed by the incidence of maternal and fetal complications in the insulin and glyburide treated groups.
  
  
  RESULTS
  The achievement of glycemic control between the insulin and the glyburide treated groups showed no significant difference (97.1%, 93.8%). The occurrence of maternal complications (P = 0.87) and fetal complications (P = 0.32) were comparable between the insulin and glyburide treated groups.
  
  
  CONCLUSIONS
  Glyburide was found to be as efficacious as insulin in achieving euglycemia in the treatment of gestational diabetic women who require treatment beyond diet control.
authors.affiliation: Obstetrics and Gynaecology Department, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
authors.forename: Anjali
authors.initials: A
authors.lastname: Tempe
authors.forename: Ronita Devi
authors.initials: RD
authors.lastname: Mayanglambam
mesh_terms: D000328:Adult; D016640:Diabetes, Gestational / Q000188:drug therapy*; D005260:Female; D005315:Fetal Diseases / Q000209:etiology; D005905:Glyburide / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use; D011247:Pregnancy; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D005905:Glyburide