title: [Differentially expressed proteins in serum among different Chinese medical syndrome types of primary liver cancer in the perioperative period of interventional treatment].
abstract: OBJECTIVE
  To explore different expressions of serum proteins among different Chinese medical syndrome types of primary liver cancer (PLC) in the perioperative period of interventional treatment, and to explore its significance.
  
  
  METHODS
  Totally 154 PLC patients were assigned to Gan depression syndrome (GDS, 37 cases), Pi deficiency syndrome (PDS, 45 cases), dampness heat syndrome (DHS, 18 cases), blood stasis syndrome (BSS, 28 cases), and yin deficiency syndrome (YDS, 26 cases). The mass spectra of serum proteins were analyzed by using surface enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOF-MS). By combining the features of Chinese medical syndromes, the different expressions of serum proteins among different Chinese medical syndrome types of PLC in the perioperative period of interventional treatment were explored.
  
  
  RESULTS
  One week before interventional treatment, there was statistical difference in the expression of serum protein peak with mass-to-charge ratio (M/Z) being 3,392, 4,970, 5,911, 6,200, and 8,575 Da (P <0.05, P < 0.01). The aforesaid differentially expressed protein peaks occurred simultaneously in PDS and BSS. One week after interventional treatment, the expression of the serum protein peak was down-regulated in YDS syndrome with M/Z being 8,575 Da, showing statistical difference (P <0.01).
  
  
  CONCLUSIONS
  Different peaks of serum proteins occurred in different Chinese medical syndrome types of PLC in the perioperative period of interventional treatment.
authors.affiliation: College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China. miss-ysf@126.com
authors.forename: Su-fang
authors.initials: SF
authors.lastname: Yang
mesh_terms: D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000175:diagnosis*; D008516:Medicine, Chinese Traditional; D059035:Perioperative Period; D020543:Proteome / Q000378:metabolism*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D016710:Yin Deficiency / Q000097:blood / Q000175:diagnosis*
chemical_list: D020543:Proteome