title: A novel 11;18 translocation in a case of acute myeloid leukemia with maturation.
abstract: Acute myeloid leukemia with maturation (AML-M2) is associated with the 8;21 translocation. For the first time in an adult patient with AML-M2, a novel unbalanced translocation involving the short arm of chromosome 11 and long arm of chromosome18 with new breakpoints is presented. CD82 on band 11p11.2 and GATA 6 on 18q11.2 may play a role in the pathogenesis of de novo AML M2. The report with translocation (11;18)(p11.2;q11.2), as the sole cytogenetic abnormality provides more data on the leukemogenesis of de novo AML M2.
authors.affiliation: Department of Laboratory Medicine, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India.
authors.forename: Devi G
authors.initials: DG
authors.lastname: Sandhya
authors.forename: Faiq
authors.initials: F
authors.lastname: Ahmed
authors.forename: Kavita
authors.initials: K
authors.lastname: Khadke
authors.forename: Sudha S
authors.initials: SS
authors.lastname: Murthy
authors.forename: Senthil J
authors.initials: SJ
authors.lastname: Rajappa
keywords: Acute myeloid leukemia with maturation 2; CD82; GATA6; chromosomal abnormality; immunophenotyping; translocation 11;18