title: Transcriptional and post-transcriptional regulation of Drosophila germline stem cells and their differentiating progeny.
abstract: In this chapter we will concentrate on the transcriptional and translational regulations that govern the development and differentiation of male germline cells. Our focus will be on the processes that occur during differentiation, that distinguish the differentiating population of cells from their stem cell parents. We discuss how these defining features are established as cells transit from a stem cell character to that of a fully committed differentiating cell. The focus will be on how GSCs differentiate, via spermatogonia, to spermatocytes. We will achieve this by first describing the transcriptional activity in the differentiating spermatocytes, cataloguing the known transcriptional regulators in these cells and then investigating how the transcription programme is set up by processes in the progentior cells. This process is particularly interesting to study from a stem cell perspective as the male GSCs are unipotent, so lineage decisions in differentiating progeny of stem cells, which occurs in many other stem cell systems, do not impinge on the behaviour of these cells.
authors.affiliation: School of Biosciences, Cardiff University, Cardiff, CF10 3AX, UK. white-cooperh@cf.ac.uk
authors.forename: Helen
authors.initials: H
authors.lastname: White-Cooper
authors.forename: Simona
authors.initials: S
authors.lastname: Caporilli
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D008297:Male; D014176:Protein Biosynthesis; D015398:Signal Transduction; D013090:Spermatocytes / Q000166:cytology / Q000378:metabolism*; D013093:Spermatogonia / Q000166:cytology / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D013737:Testis / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors