title: [Chemical constituents of stems and leaves of Salvia yunnanensis and their anti-angiogeneic activities].
abstract: Present study was focused on the chemical constituents of the stems and leaves of Salvia yunnanensis C . H. Wright and their anti-angiogeneic activities. The compounds were isolated by column chromatography over silica gel and Sephadex LH-20, and other isolation techniques. Their structures were elucidated on the basis of spectral analysis and chemical evidences. Their anti-angiogeneic activities were evaluated by the chicken chorioallantoic membrane (CAM) neovascularisation model. Seven compounds were separated and identified as ( + ) -spathulenol( 1), 5,7,4'-trihydroxyflavanone(2) , beta-amyrin(3), 3 beta-hydroxy-12-ursene(4), 2alpha,3 beta-dihydroxyursa-12-en-28-oic acid(5), ursolic acid (6) and 3-oxo-12-ursen-28-oic acid (7). Compounds 1, 2, 5 and 6 were obtained from this plant for the first time. Compounds 5 (an oleanane compound) and 6 (an ursane compound) could inhibit angiogenesis significantly in a dose-dependent manner.
authors.affiliation: Kunming University of Science and Technology, Kunning 650500, China. xcheng0871@163.com
authors.forename: Cheng
authors.initials: C
authors.lastname: Xiang
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Zhu
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Zhuang
authors.forename: Lin-Dong
authors.initials: LD
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Bao-Cai
authors.initials: BC
authors.lastname: Li
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D049033:Chorioallantoic Membrane / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*; D027544:Salvia / Q000737:chemistry*
chemical_list: D020533:Angiogenesis Inhibitors; D004365:Drugs, Chinese Herbal