title: Comparison of interleukin-1β levels in gingival crevicular fluid and peri-implant crevicular fluid and its relationship with clinical indexes.
abstract: OBJECTIVE
  Interleukin-1β (IL-1β) is one of the most important cytokines which seems to have an important role in the inflammatory process in gingival and peri-implant tissues. The aim of this split-mouth study was to investigate the relationship between the concentration of IL-1β in gingival crevicular fluid (GCF) and peri-implant crevicular fluid (PICF) and clinical parameters such as plaque index (PI), gingival index (GI), pocket depth (PD) and bone loss (BL).
  
  
  METHODS
  In 32 patients, PICF and GCF samples of 41 implants and 41 contralateral teeth were collected and IL-1β was determined by enzyme-linked immunosorbent assay (ELISA). PI,GI,PD and BL were recorded for each of the samples.
  
  
  RESULTS
  The positive correlation between the level of IL-1β and PI, GI, PD and BL in both groups was observed (P<0.0001). In similar conditions, the level of IL-1β was greatly higher in PICF than GCF (75.26 pg/μl and 45.71 pg/μl, respectively) (P=0.001).
  
  
  CONCLUSIONS
  The findings of the present study indicated that the level of IL-1β may be an important supplement to clinical findings in measuring the health status of gingival or peri-implant tissues.
authors.affiliation: Assistant Professor, Department of Periodontics & Dental Implant Research Center of Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Siamak
authors.initials: S
authors.lastname: Yaghobee
authors.forename: Afshin
authors.initials: A
authors.lastname: Khorsand
authors.forename: Mojgan
authors.initials: M
authors.lastname: Paknejad
keywords: Gingival Crevicular Fluid; Interleukin-1beta; Peri-Implantitis