title: Aspirin sensitivity does not compromise quality-of-life outcomes in patients with Samter's triad.
abstract: OBJECTIVE
  To demonstrate that quality-of-life outcomes after endoscopic sinus surgery are not compromised in patients with Samter's triad (asthma, nasal polyps, aspirin sensitivity) when compared to patients with eosinophilic chronic rhinosinusitis with nasal polyposis (eCRSwP) who are not aspirin sensitive.
  
  
  METHODS
  Retrospective review of prospectively collected data.
  
  
  METHODS
  Thirty-two patients with Samter's triad were identified from a prospectively collected patient database from 2003 to 2012. Preoperative and postoperative symptom and endoscopy scores were compared to those of 37 consecutive patients with eCRSwP who were not aspirin sensitive (control). Student t test and Fisher exact test were used to examine for differences between the two groups. Symptom scores were assessed using the 20-item Sino-Nasal Outcome Test (SNOT-20). Endoscopy findings were scored according to the Lund-Kennedy methodology.
  
  
  RESULTS
  Samter's triad patients had significantly worse disease preoperatively when compared to the control group: SNOT-20 (31.1 vs. 22.1, P = .004), endoscopy score (10.9 vs. 7.6, P = .0005), and Lund-Mackay computed tomography score (18.9 vs. 13.9, P = .0001). Although postoperative endoscopy scores remained worse in the Samter's triad group, postoperative SNOT-20 scores were comparable to those of the control group at ≥ 3 years follow-up (22.8 vs. 17.3, P = .43).
  
  
  CONCLUSIONS
  Although Samter's triad patients present with more severe disease and are more likely to undergo revision surgery, they have postoperative quality-of-life outcomes that are comparable to patients with eCRSwP who are not aspirin sensitive. This is the first study to utilize a disease-specific, validated outcomes instrument in comparing Samter's triad patients with aspirin-tolerant patients who have nasal polyposis and tissue eosinophilia.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Georgia Regents University, Augusta, Georgia, U.S.A.
authors.forename: David W
authors.initials: DW
authors.lastname: Jang
authors.forename: Brett T
authors.initials: BT
authors.lastname: Comer
authors.forename: Vasileios A
authors.initials: VA
authors.lastname: Lachanas
authors.forename: Stilianos E
authors.initials: SE
authors.lastname: Kountakis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000150:complications*; D002908:Chronic Disease; D004342:Drug Hypersensitivity / Q000150:complications*; D004724:Endoscopy; D004802:Eosinophilia / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications* / Q000601:surgery*; D011788:Quality of Life; D012189:Retrospective Studies; D012220:Rhinitis / Q000150:complications* / Q000601:surgery*; D012852:Sinusitis / Q000150:complications* / Q000601:surgery*; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
keywords: Chronic rhinosinusitis; Samter's triad; aspirin sensitivity; nasal polyposis