title: Low vitamin D concentration is not associated with increased mortality and morbidity after cardiac surgery.
abstract: OBJECTIVE
  To determine the effect of vitamin D on postoperative outcomes in cardiac surgical patients.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Single institution-teaching hospital.
  
  
  METHODS
  Adult cardiac surgical patients with perioperative 25-hydroxyvitamin D measurements.
  
  
  METHODS
  None. We gathered information from the Cardiac Anesthesiology Registry that was obtained at the time of the patients' visit/hospitalization.
  
  
  RESULTS
  We used data of 18,064 patients from the Cardiac Anesthesiology Registry; 426 patients with 25-hydroxyvitamin D measurements met our inclusion criteria. Association with Vitamin D concentration and composite of 11 cardiac morbidities was done by multivariate (i.e., multiple outcomes per subject) analysis. For other outcomes separate multivariable logistic regressions and adjusting for the potential confounders was used. The observed median vitamin D concentration was 19 [Q1-Q3∶12, 30] ng/mL. Vitamin D concentration was not associated with our primary composite of serious cardiac morbidities (odds ratio [OR], 0.96; 95% CI, 0.86-1.07). Vitamin D concentration was also not associated with any of the secondary outcomes: neurologic morbidity (P = 0.27), surgical (P = 0.26) or systemic infections (P = 0.58), 30-day mortality (P = 0.55), or length of initial intensive care unit (ICU) stay (P = 0.04).
  
  
  CONCLUSIONS
  Our analysis suggests that perioperative vitamin D concentration is not associated with clinically important outcomes, likely because the outcomes are overwhelmingly determined by other baseline and surgical factors.
authors.affiliation: Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, United States of America. turana@ccf.org
authors.forename: Alparslan
authors.initials: A
authors.lastname: Turan
authors.forename: Martin
authors.initials: M
authors.lastname: Grady
authors.forename: Jing
authors.initials: J
authors.lastname: You
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Mascha
authors.forename: Worasak
authors.initials: W
authors.lastname: Keeyapaj
authors.forename: Ryu
authors.initials: R
authors.lastname: Komatsu
authors.forename: C Allen
authors.initials: CA
authors.lastname: Bashour
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Sessler
authors.forename: Leif
authors.initials: L
authors.lastname: Saager
authors.forename: Andrea
authors.initials: A
authors.lastname: Kurz
mesh_terms: D000328:Adult; D006348:Cardiac Surgical Procedures / Q000401:mortality*; D006801:Humans; D009017:Morbidity; D016896:Treatment Outcome; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D