title: A naphthalocyanine based near-infrared photosensitizer: synthesis and in vitro photodynamic activities.
abstract: A hydrophilic near-infrared (NIR) photosensitizer featuring a naphthalocyanine core and peripheral carboxylate acid groups was synthesized and characterized. Its photophysical and photochemical properties were studied and compared with phthalocyanine. Due to the extended π-conjugation, both the Q band and fluorescence emit of this naphthalocyanine bathochromically shift to NIR region. It also exhibits superior NIR photodynamic efficiency to phthalocyanine as evidenced by high efficiency in generating singlet oxygen (ΦΔ=0.66) and in vitro phototoxicity toward Hela human cervical cancer cells. Therefore, this novel naphthalocyanine could potentially be a NIR photosensitizer for photodynamic therapy.
authors.affiliation: State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Luan
authors.forename: Lanlan
authors.initials: L
authors.lastname: Ding
authors.forename: Weijia
authors.initials: W
authors.lastname: Zhang
authors.forename: Jiawei
authors.initials: J
authors.lastname: Shi
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Yu
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
mesh_terms: D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C483615:zinc naphthalocyanine