title: B-regulatory cells in autoimmunity and immune mediated inflammation.
abstract: B cells are a source of inhibitory cytokines such as IL-10 and TGF-β. The ability of being B-regulatory cells (B-regs) was shown to be driven by many stimulatory factors such as toll-like receptors, CD40-ligand and others. However, the characterization of B-regs is still underway. B-regs express high levels of CD25, CD86, IL-10 and TGF-β. In addition, we propose that semaphorin3A is a regulatory molecule and therefore can serve as one of the additional markers for B-regs. This subset of B cells was able to suppress Th1 proliferation, thus contributing to the maintenance of self-tolerance. Finally, the potentiation of B-reg function should become the aim of many immunomodulatory drugs, contributing to a better control of autoimmune diseases.
authors.affiliation: Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel.
authors.forename: Zahava
authors.initials: Z
authors.lastname: Vadasz
authors.forename: Tharwat
authors.initials: T
authors.lastname: Haj
authors.forename: Aharon
authors.initials: A
authors.lastname: Kessel
authors.forename: Elias
authors.initials: E
authors.lastname: Toubi
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D060151:B-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D016207:Cytokines; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors