title: Prognosis and risk stratification of young adults with Brugada syndrome.
abstract: Prognosis and risk factors for patients age 35years or younger with Brugada syndrome (BrS) were prospectively explored in a sub-analysis of the Japan Idiopathic Ventricular Fibrillation Study (J-IVFS) registry. During the period from February 2002 to January 2011, 69 cases (mean age 30±6years, male=66) of the young (at or less than 35years old) BrS were enrolled in J-IVFS and the clinical course was followed for more than 1year. They were divided into 3 groups: documented ventricular fibrillation (VF) or aborted sudden cardiac death (SCD) (VF group, 12 cases), syncope without documentation of VF (Syncope group, 17 cases) and asymptomatic group (Asympt. group, 40 cases). During a mean follow-up period of 43±27months, cardiac events (VF and/or SCD) developed in 8 cases, with 5 of 12 cases in the VF (41.7%), 2 of 17 cases in the Syncope (11.8%) and 1 of 40 cases in the Asympt. group (2.5%). The VF group had a worse prognosis for cardiac events than the Syncope and Asympt. group. Multivariate analysis revealed symptoms as a risk factor for predicting cardiac events.
authors.affiliation: Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan. m-hiraoka0401@ivory.plala.or.jp
authors.forename: Masayasu
authors.initials: M
authors.lastname: Hiraoka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Takagi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sekiguchi
authors.forename: Naohiko
authors.initials: N
authors.lastname: Aihara
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Aonuma
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D053840:Brugada Syndrome / Q000175:diagnosis* / Q000401:mortality*; D015984:Causality; D015897:Comorbidity; D016757:Death, Sudden, Cardiac / Q000453:epidemiology*; D004562:Electrocardiography / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D013575:Syncope / Q000175:diagnosis* / Q000401:mortality*; D014693:Ventricular Fibrillation / Q000175:diagnosis* / Q000401:mortality*; D055815:Young Adult