title: The neutrophils response after laparoscopic and open cholecystectomy.
abstract: OBJECTIVE
  This study want to examine (a) whether neutrophils, the neutrophil-elastase, C-reactive protein and the Interleukin- 6 are modified and how, in patients after laparoscopic cholecystectomy open cholecystectomy; (b) whether these findings are indicative of an increased risk to develop infectious complications.
  
  
  METHODS
  Circulating Interleukin-6 level, C-reactive protein and neutrophil-elastase were measured in 71 patients (35 underwent open cholecystectomy and 36 laparoscopic cholecystectomy). The diagnosis was confirmed by ultrasound examination. During hospitalization the patients were not given antispastic drugs, steroids, or nonsteroidal antiinflammatory drugs (NSAID).
  
  
  RESULTS
  The increase in the serum Interleukin-6 and neurtophil-elastase, during laparoscopic cholecystectomy, was found to be significantly smaller than that during open cholecystectomy and resulted in a smaller extent of postoperative elevations for C-reactive protein. We recorded three cases (8.5%) of postoperative infections in the "open'" group and neutrophil- elastase values normalized later in patient with complications.
  
  
  CONCLUSIONS
  There were significant associations between the response areas of Interleukin-6, C-reactive protein and neutrophil- elastase levels. Neutrophils-elastase level is a more sensible inflammatory marker in comparison to the IL-6 and C-reactive protein. Excessive and prolonged post injury elevations of these mediators are associated with increased morbidity.
authors.forename: Federico
authors.initials: F
authors.lastname: Sista
authors.forename: Mario
authors.initials: M
authors.lastname: Schietroma
authors.forename: Francesco
authors.initials: F
authors.lastname: Carlei
authors.forename: Emanuela Marina
authors.initials: EM
authors.lastname: Cecilia
authors.forename: Federica
authors.initials: F
authors.lastname: Piccione
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Santis
authors.forename: Laura
authors.initials: L
authors.lastname: Lancione
authors.forename: Daniela
authors.initials: D
authors.lastname: Iannucci
authors.forename: Antonio
authors.initials: A
authors.lastname: Giuliani
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Amicucci
authors.forename: Sergio
authors.initials: S
authors.lastname: Leardi
mesh_terms: D002763:Cholecystectomy; D017081:Cholecystectomy, Laparoscopic; D006801:Humans; D015850:Interleukin-6; D010535:Laparoscopy; D009504:Neutrophils
chemical_list: D015850:Interleukin-6