title: Long-term topical oestrogen treatment of sun-exposed facial skin in post-menopausal women does not improve facial wrinkles or skin elasticity, but induces matrix metalloproteinase-1 expression.
abstract: It is controversial whether treatment with oestrogen stimulates collagen production or accumulation in sun-exposed skin. The aim of this study was to determine the effect of long-term treatment with topical oestrogen on photoaged facial skin, with regard to wrinkle severity, and expression of procollagen and matrix metalloproteinase-1 enzyme. Two groups of 40 post-menopausal women applied either 1 g of 1% oestrone or vehicle cream once daily to the face for 24 weeks. Visiometer R1-R5 values (skin wrinkles) and Cutometer values (skin elasticity) were not significantly improved in the oestrone group after 24 weeks of treatment. Type I procollagen immunostaining did not increase in the oestrone group compared with the control group. However, levels of matrix metalloproteinase-1 mRNA increased robustly (10.3 times) in oestrone-treated skin compared with vehicle-treated skin. Thus, treatment with topical oestrogen may be deleterious in ultraviolet-induced skin ageing, at least in part, through induction of matrix metalloproteinase-1 (MMP-1) expression in human skin.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hyun-Sun
authors.initials: HS
authors.lastname: Yoon
authors.forename: Se-Rah
authors.initials: SR
authors.lastname: Lee
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000287:Administration, Topical; D024042:Collagen Type I / Q000235:genetics / Q000378:metabolism*; D004548:Elasticity / Q000187:drug effects; D004967:Estrogens / Q000494:pharmacology*; D004970:Estrone / Q000494:pharmacology*; D005148:Facial Dermatoses / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D005260:Female; D000071837:Fibrillins; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics / Q000378:metabolism*; D008840:Microfilament Proteins / Q000235:genetics; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics; D017698:Postmenopause; D012333:RNA, Messenger / Q000378:metabolism; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D015595:Skin Aging / Q000187:drug effects* / Q000502:physiology; D013472:Sunlight / Q000009:adverse effects; D013997:Time Factors
chemical_list: D024042:Collagen Type I; D004967:Estrogens; D000071837:Fibrillins; C416830:GREB1 protein, human; D008840:Microfilament Proteins; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D004970:Estrone; D020781:Matrix Metalloproteinase 1