title: A murine model of stent implantation in the carotid artery for the study of restenosis.
abstract: Despite the considerable progress made in the stent development in the last decades, cardiovascular diseases remain the main cause of death in western countries. Beside the benefits offered by the development of different drug-eluting stents, the coronary revascularization bears also the life-threatening risks of in-stent thrombosis and restenosis. Research on new therapeutic strategies is impaired by the lack of appropriate methods to study stent implantation and restenosis processes. Here, we describe a rapid and accessible procedure of stent implantation in mouse carotid artery, which offers the possibility to study in a convenient way the molecular mechanisms of vessel remodeling and the effects of different drug coatings.
authors.affiliation: Institute for Molecular Cardiovascular Research, RWTH Aachen University.
authors.forename: Sakine
authors.initials: S
authors.lastname: Simsekyilmaz
authors.forename: Fabian
authors.initials: F
authors.lastname: Schreiber
authors.forename: Stefan
authors.initials: S
authors.lastname: Weinandy
authors.forename: Felix
authors.initials: F
authors.lastname: Gremse
authors.forename: Tolga Taha
authors.initials: TT
authors.lastname: Sönmez
authors.forename: Elisa A
authors.initials: EA
authors.lastname: Liehn
mesh_terms: D000497:Alloys; D000818:Animals; D002339:Carotid Arteries / Q000601:surgery*; D023903:Coronary Restenosis / Q000473:pathology* / Q000628:therapy; D004195:Disease Models, Animal; D054855:Drug-Eluting Stents; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D058226:Plaque, Atherosclerotic / Q000473:pathology; D015607:Stents
chemical_list: D000497:Alloys; C013616:nitinol