title: [Transfusion-related acute lung injury (TRALI) - review].
abstract: TRALI is a major cause of serious morbidity and mortality associated with a blood transfusion. It is clinically manifested by acute respiratory distress within 6 hours of completion of transfusion. Neutrophils have the key role in the pathogenesis. They are activated mostly with leukocyte antibodies (HLA and granulocyte) that are present mainly in plasma containing blood products. TRALI is a clinical diagnosis based on hypoxemia and positive finding on lung X-ray examination. The treatment is only supportive and the mortality is about 5% to 10%. The major preventive measure is transfusing blood products from donors without leukocyte antibodies.
authors.affiliation: Krevní Centrum FN, Ostrava, Vedoucí Pracovisté MUDr. Z. Cermáková, PhD. zuzana.cermakova@fno.cz
authors.forename: Z
authors.initials: Z
authors.lastname: Cermáková
authors.forename: O
authors.initials: O
authors.lastname: Simetka
authors.forename: M
authors.initials: M
authors.lastname: Kořístka
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology / Q000276:immunology / Q000401:mortality / Q000628:therapy; D006801:Humans; D065227:Transfusion Reaction