title: Age-associated prevalence of Toxoplasma gondii in 8281 pregnant women in Poland between 2004 and 2012.
abstract: This study aimed to describe Toxoplasma gondii prevalence in Polish pregnant women and the incidence rates of congenital infections in their neonates observed between 2004 and 2012. Serological tests for T. gondii-specific IgG and IgM antibodies were performed on serum samples of 8281 pregnant women treated at the Polish Mother's Memorial Hospital Research Institute in Lodz. The yearly seroconversion rate for T. gondii IgG antibodies was estimated using a mathematical model to determine the dependency between age and prevalence. Mean prevalence of IgG antibodies between 2004 and 2012 in pregnant women was 40·6% [95% confidence interval (CI) 39·6-41·7] and increased with age with a yearly seroconversion rate of 0·8% (95% CI 0·6-1·0, P<0·001). Assuming a T. gondii materno-fetal transmission rate of 30% gave an estimate of 1·80/1000 neonates as congenitally infected. The increased mean age (28·7 vs 26·7 years, P<0·001) of pregnant women was probably the most important factor in abolishing the effect of falling prevalence rates.
authors.affiliation: Department of Fetal-Maternal Medicine and Gynecology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Nowakowska
authors.affiliation: Department of Fetal-Maternal Medicine and Gynecology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Wujcicka
authors.affiliation: Department of Environmental Epidemiology, Institute of Occupational Medicine, Lodz, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Sobala
authors.affiliation: Department of Microbiology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Spiewak
authors.affiliation: Department of Fetal-Maternal Medicine and Gynecology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Gaj
authors.affiliation: Department of Fetal-Maternal Medicine and Gynecology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Wilczyński
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D015994:Incidence; D007231:Infant, Newborn; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000453:epidemiology*; D015995:Prevalence; D014122:Toxoplasma; D014123:Toxoplasmosis / Q000453:epidemiology*; D014125:Toxoplasmosis, Congenital / Q000453:epidemiology
chemical_list: D007075:Immunoglobulin M