title: New advances in urea transporter UT-A1 membrane trafficking.
abstract: The vasopressin-regulated urea transporter UT-A1, expressed in kidney inner medullary collecting duct (IMCD) epithelial cells, plays a critical role in the urinary concentrating mechanisms. As a membrane protein, the function of UT-A1 transport activity relies on its presence in the plasma membrane. Therefore, UT-A1 successfully trafficking to the apical membrane of the polarized epithelial cells is crucial for the regulation of urea transport. This review summarizes the research progress of UT-A1 regulation over the past few years, specifically on the regulation of UT-A1 membrane trafficking by lipid rafts, N-linked glycosylation and a group of accessory proteins.
authors.affiliation: Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA. gchen3@emory.edu.
authors.forename: Guangping
authors.initials: G
authors.lastname: Chen
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D007685:Kidney Tubules, Collecting / Q000378:metabolism*; D021962:Membrane Microdomains / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism*; D014508:Urea / Q000378:metabolism; D000096982:Urea Transporters
chemical_list: D026901:Membrane Transport Proteins; D014508:Urea; D000096982:Urea Transporters