title: Long-term 2- to 5-year clinical and functional outcomes of minimally invasive surgery for adult scoliosis.
abstract: METHODS
  A retrospective study.
  
  
  OBJECTIVE
  We assess MIS technique's clinical and functional outcomes during a 2- to 5-year period.
  
  
  BACKGROUND
  Traditional surgical approaches for adult scoliosis are associated with significant blood loss and morbidity, in a population that is often elderly with multiple medical comorbidities. Minimally invasive surgery (MIS) represents a newer method of achieving similar long-term outcomes but considerably lower morbidity and complication rates.
  
  
  METHODS
  We reviewed 71 patients who underwent MIS correction of spinal deformity with fusion of 2 or more levels including: degenerative scoliosis (54), idiopathic scoliosis (11), and iatrogenic scoliosis (6). All underwent a combination of 3 MIS techniques: direct lateral interbody fusion (66), axial lumbar interbody fusion (34), and posterior instrumentation (67). Thirty-six patients were staged with direct lateral interbody fusion done first followed by the posterior instrumentation and fusion including axial lumbar interbody fusion done 3 days later.
  
  
  RESULTS
  Mean age was 64 years (20-84 yr). Mean follow-up was 39 months (24-60 mo). Patients with 1-stage same-day surgery had a mean blood loss of 412 mL and a mean surgical time of 291 minutes. Patients with 2-stage surgery had a mean blood loss of 314 mL and surgical time of 183 minutes for direct lateral interbody fusion and 357 mL and 243 minutes, respectively for posterior instrumentation and axial lumbar interbody fusion. Mean hospital stay was 7.6 days (2-26 d). The mean preoperative Cobb angle was 24.7° (8.3°-65°), which corrected to 9.5° (0.6°-28.8°). Mean preoperative Coronal balance was 25.5 mm, which corrected to 11 mm. Mean preoperative sagittal balance was 31.7 mm and corrected to 10.7 mm. The mean preoperative lumbar apical vertebral translation was 24 mm and corrected to 12 mm. Fourteen patients had adverse events requiring intervention: 4 pseudarthrosis, 4 persistent stenosis, 1 osteomyelitis, 1 adjacent segment discitis, 1 late wound infection, 1 proximal junctional kyphosis, 1 screw prominence, 1 idiopathic cerebellar hemorrhage, and 2 wound dehiscence.
  
  
  CONCLUSIONS
  A combination of 3 novel MIS techniques allows comparable correction of adult spinal deformity, with low pseudarthrosis rates, significantly improved functional outcomes, and excellent clinical and radiological improvement, but considerably lowers morbidity and complication rates at early and long-term follow-up.
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, CA, USA. anandn@cshs.org
authors.forename: Neel
authors.initials: N
authors.lastname: Anand
authors.forename: Eli M
authors.initials: EM
authors.lastname: Baron
authors.forename: Babak
authors.initials: B
authors.lastname: Khandehroo
authors.forename: Sheila
authors.initials: S
authors.lastname: Kahwaty
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016208:Databases, Factual / Q000639:trends; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods* / Q000639:trends; D011859:Radiography; D020127:Recovery of Function / Q000502:physiology*; D012189:Retrospective Studies; D012600:Scoliosis / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult