title: PIUS: peptide identification by unbiased search.
abstract: CONCLUSIONS
  We present PIUS, a tool that identifies peptides from tandem mass spectrometry data by analyzing the six-frame translation of a complete genome. It differs from earlier studies that have performed such a genomic search in two ways: (i) it considers a larger search space and (ii) it is designed for natural peptide identification rather than proteomics. Differently from other peptidomics tools designed for genome-wide searches, PIUS does not limit the analysis to a set of sequences that match a list of de novo reconstructions.
  
  
  BACKGROUND
  Source code, executables and a detailed technical report are freely available at http://dtai.cs.kuleuven.be/ml/systems/pius.
  
  
  BACKGROUND
  eduardo.costa@cs.kuleuven.be
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Department of Computer Science, KU Leuven, Celestijnenlaan 200A, B-3001 Heverlee, Belgium. eduardo.costa@cs.kuleuven.be
authors.forename: Eduardo P
authors.initials: EP
authors.lastname: Costa
authors.forename: Gerben
authors.initials: G
authors.lastname: Menschaert
authors.forename: Walter
authors.initials: W
authors.lastname: Luyten
authors.forename: Kurt
authors.initials: K
authors.lastname: De Grave
authors.forename: Jan
authors.initials: J
authors.lastname: Ramon
mesh_terms: D000465:Algorithms; D000818:Animals; D002460:Cell Line; D030562:Databases, Protein; D016678:Genome; D023281:Genomics; D051379:Mice; D010455:Peptides / Q000032:analysis / Q000737:chemistry*; D040901:Proteomics / Q000379:methods; D020539:Sequence Analysis, Protein; D012984:Software; D053719:Tandem Mass Spectrometry
chemical_list: D010455:Peptides