title: Enantioselective Mukaiyama-Michael with 2-enoyl pyridine N-oxides catalyzed by PYBOX-DIPH-Zn(II)-complexes at ambient temperature.
abstract: A chiral PYBOX-DIPH-Zn(II) catalyzed enantioselective Mukaiyama-Michael reaction of acyclic silyl enol ethers with 2-enoylpyridine N-oxides has been studied in external additive free conditions at ambient temperature. The methodology offers straightforward access to a variety of functionalized chiral 1,5-dicarbonyl compounds, which could easily be elaborated into synthetically viable pyrones via hydrolysis followed by cyclization. A transition state model has been proposed to explain the stereochemical outcome.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal, M.P. 460 023, India.
authors.forename: Subhrajit
authors.initials: S
authors.lastname: Rout
authors.forename: Sumit K
authors.initials: SK
authors.lastname: Ray
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Singh