title: [Comparison of neuroprotective effects of anticonvulsant drugs in brain injury therapy].
abstract: The effect of anticonvulsant drugs on posttraumatic convulsive reactions and the stability of the brain with respect to complete ischemia and hypoxia upon brain injury has been studied in animals with model contact craniocerebral trauma. It is established that lamotrigine, topiramate, and sodium valproate produce a strong effect on convulsive reactions, while magnesium sulfate and gabapentin produce a moderate action. The antiishemic and antihypoxic action of lamotrigine and sodium valproate is stronger than that of topiramate and gabapentin.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Belozertsev
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Zapol'skaia
authors.forename: F Iu
authors.initials: FIu
authors.lastname: Belozertsev
authors.forename: S V
authors.initials: SV
authors.lastname: Iuntsev
mesh_terms: D000588:Amines / Q000494:pharmacology; D000818:Animals; D021461:Animals, Outbred Strains; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D001930:Brain Injuries / Q000188:drug therapy* / Q000503:physiopathology; D002545:Brain Ischemia / Q000188:drug therapy / Q000503:physiopathology; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077206:Gabapentin; D000077213:Lamotrigine; D008278:Magnesium Sulfate / Q000494:pharmacology; D051379:Mice; D051381:Rats; D012640:Seizures / Q000503:physiopathology / Q000517:prevention & control*; D000077236:Topiramate; D014227:Triazines / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D014227:Triazines; D000077236:Topiramate; D005632:Fructose; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D000077206:Gabapentin; D008278:Magnesium Sulfate; D000077213:Lamotrigine