title: Innovative approaches for enhancing cancer gene therapy.
abstract: Gene therapy provides a novel platform for therapeutic intervention of several genetic and non-genetic disorders. With the recent developments in the field, a wide variety of viral and non-viral vectors have emerged that can deliver genetic payloads to target cells. However, non-targeted delivery of transgenes often results in undesirable effects, low tumor transduction, and reduced therapeutic index. In this review, we focus on some of the novel approaches that can be used to meet the present challenges in the field and translate the potential of cancer gene therapy from 'bench to bedside' in the near future.
authors.affiliation: Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Bhatia
authors.forename: Mitchell E
authors.initials: ME
authors.lastname: Menezes
authors.forename: Swadesh K
authors.initials: SK
authors.lastname: Das
authors.forename: Luni
authors.initials: L
authors.lastname: Emdad
authors.forename: Santanu
authors.initials: S
authors.lastname: Dasgupta
authors.forename: Xiang-Yang
authors.initials: XY
authors.lastname: Wang
authors.forename: Devanand
authors.initials: D
authors.lastname: Sarkar
authors.forename: Paul B
authors.initials: PB
authors.lastname: Fisher
mesh_terms: D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D045423:Microbubbles; D053758:Nanoparticles; D009369:Neoplasms / Q000628:therapy*; D014176:Protein Biosynthesis; D014158:Transcription, Genetic; D014161:Transduction, Genetic