title: Cycloartane triterpenoid saponins from water soluble of Passiflora edulis Sims and their antidepressant-like effects.
abstract: BACKGROUND
  Various species of genus Passiflora have been used as traditional folk medicines owing to their sedative and anti-hypertensive properties. Passiflora edulis Sims most widely grown in the warm temperate for their fragrant fruits and their twigs and leaves are used as a folk medicine for treating both anxiety and nervousness in American countries. The present study was to evaluate the antidepressant-like effect and the active components of this plant.
  
  
  METHODS
  The alcohol extracts of the stems (PES, 10 and 2 g/kg of the plant materials) and leaves (PEL, 10 and 2 g/kg of the plant materials) of Passiflora edulis Sims were orally administered to mice for 7 day. The animals were tested in the forced swim test (FST) and tail suspension test (TST). After behavioral assay of ethanol extract, phytochemical research of the stems and leaves (5.7 kg) of Passiflora edulis Sims were developed and further bioactive verification of monomeric compounds were conducted.
  
  
  RESULTS
  There are mainly cycloartane triterpenoids and their saponins isolated from this plant, including two new cycloartane triterpenoid saponins named cyclopassifloside ХII (1) and ХIII (2), together with six known cycloartane triterpenoids, cyclopassifloic acids B and E, cyclopassiflosides II, VI, IX and XI. The ethanol extract of Passiflora edulis Sims together with isolated compounds cyclopassiflosides IX and XI may possess antidepressant-like effect.
  
  
  CONCLUSIONS
  Cycloartane triterpenoid was one of the main compositions of Passiflora edulis Sims and possess antidepressant-like activity.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Wang
authors.forename: Feng-Qing
authors.initials: FQ
authors.lastname: Xu
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Shang
authors.forename: Huai
authors.initials: H
authors.lastname: Xiao
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Fan
authors.forename: Fa-Wu
authors.initials: FW
authors.lastname: Dong
authors.forename: Jiang-Miao
authors.initials: JM
authors.lastname: Hu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D003863:Depression / Q000188:drug therapy*; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D029598:Passiflora; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts; D012503:Saponins / Q000627:therapeutic use*; D014315:Triterpenes / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C085352:cycloartane
keywords: Antidepressant-like effect; Cyclopassifloside; Passiflora edulis Sims