title: New rotenoids and coumaronochromonoids from the aerial part of Boerhaavia erecta.
abstract: From the aerial part of Boerhaavia erecta L., three new rotenoids (3, 8, 10) and two new coumaronochromonoids (6, 11) were isolated, together with ten known compounds. The structure of the new compounds was established by one dimensional (1D)- and 2D-NMR spectroscopy, as well as high resolution-electrospray ionization (HR-ESI)-MS analysis. The absolute configuration of compound 11 was determined by UV circular dichroism spectroscopy. Compounds were evaluated for their cytotoxic activity against HeLa (human epithelial carcinoma), NCI-H460 (human lung cancer) and MCF-7 (human breast cancer) cell lines at the concentration of 100 µg/mL. Rotenoids 3, 4 and 5 showed a strong cytotoxic activity against HeLa cell line and rotenoids 5 and 8 showed good activity against MCF-7 cell line.
authors.affiliation: Department of Organic Chemistry, University of Science, National University-Ho Chi Minh City, Vietnam.
authors.forename: Thi My Lien
authors.initials: TM
authors.lastname: Do
authors.forename: Anh Vu
authors.initials: AV
authors.lastname: Truong
authors.forename: Travis George
authors.initials: TG
authors.lastname: Pinnock
authors.forename: Lawrence Michael
authors.initials: LM
authors.lastname: Pratt
authors.forename: Shigeki
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Watarai
authors.forename: Dominique
authors.initials: D
authors.lastname: Guillaume
authors.forename: Kim Phi Phung
authors.initials: KP
authors.lastname: Nguyen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D039281:Nyctaginaceae / Q000737:chemistry*; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids