title: Dedifferentiated acinic cell tumour: the harlequin of salivary gland neoplasms--an unusual variant.
abstract: We present a case of a salivary gland tumour in a 25-year-old woman with lymphadenopathy and a clinical suspicion of lymphoma. The patient had a history of rapidly enlarging mass near angle of jaw which was resected and sent for histopathological examination. A final diagnosis of acinic cell tumour with dedifferentiation was made by histomorphological and immunohistochemical studies. Acinic cell tumour can mimic any salivary neoplasm phenotypically because of its varied architectural patterns of presentation with varied cell types, hence called the harlequin of salivary gland. Acinic cell tumour with dedifferentiation is a rare aggressive variant and requires adjuvant radiotherapy for better prognosis, hence the need for accurate diagnosis and communication to the surgeon.
authors.affiliation: Department of Pathology, JN Medical College, Aligarh, Uttar Pradesh, India. vians.jain@gmail.com
authors.forename: Anshu
authors.initials: A
authors.lastname: Jain
authors.forename: Kiran
authors.initials: K
authors.lastname: Alam
authors.forename: Aroonima
authors.initials: A
authors.lastname: Misra
authors.forename: Veena
authors.initials: V
authors.lastname: Maheshwari
mesh_terms: D000328:Adult; D018267:Carcinoma, Acinar Cell / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D012468:Salivary Gland Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D016896:Treatment Outcome