title: Comparison of 2 diagnostic criteria for the behavioral variant of frontotemporal dementia.
abstract: OBJECTIVE
  The aim of this study was to compare the applicability of the 1998 consensus diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD) with the recently proposed diagnostic criteria of the International bvFTD Criteria Consortium (FTDC).
  
  
  METHODS
  We reviewed each individual item in the 1998 and FTDC criteria in 30 patients with bvFTD followed in a memory clinic (including 2 with the C9orf72 gene repeat expansion).
  
  
  RESULTS
  All patients fulfilled the FTDC criteria (40% possible, 60% probable bvFTD) but only 66.7% fulfilled the 1998 criteria. One of the C9orf72 expansion carriers did not fulfill the 1998 criteria. This discordance was always due to the presence of exclusion features in the 1998 criteria, the most common being spatial disorientation and early severe amnesia.
  
  
  CONCLUSIONS
  The new FTDC criteria are less restrictive and hence more sensitive for the diagnosis of bvFTD.
authors.affiliation: Department of Neurology, Memory Disorders Unit, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Universitat AutŒnoma de Barcelona, Barcelona, Spain.
authors.forename: Sónia
authors.initials: S
authors.lastname: Costa
authors.forename: Marc
authors.initials: M
authors.lastname: Suárez-Calvet
authors.forename: Sofia
authors.initials: S
authors.lastname: Antón
authors.forename: Oriol
authors.initials: O
authors.lastname: Dols-Icardo
authors.forename: Jordi
authors.initials: J
authors.lastname: Clarimón
authors.forename: Daniel
authors.initials: D
authors.lastname: Alcolea
authors.forename: Juan
authors.initials: J
authors.lastname: Fortea
authors.forename: María
authors.initials: M
authors.lastname: Carmona
authors.forename: Isabel
authors.initials: I
authors.lastname: Sala
authors.forename: M Belén
authors.initials: MB
authors.lastname: Sánchez-Saudinós
authors.forename: Rafael
authors.initials: R
authors.lastname: Blesa
authors.forename: Alberto
authors.initials: A
authors.lastname: Lleó
mesh_terms: D000328:Adult; D000368:Aged; D001519:Behavior / Q000502:physiology*; D000073885:C9orf72 Protein; D003937:Diagnosis, Differential; D057180:Frontotemporal Dementia / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009483:Neuropsychological Tests; D011506:Proteins / Q000235:genetics
chemical_list: D000073885:C9orf72 Protein; C568651:C9orf72 protein, human; D011506:Proteins
keywords: C9orf72; behavioral variant frontotemporal dementia; diagnosis of neurodegenerative diseases.; diagnostic criteria; differential diagnosis; frontotemporal dementia; frontotemporal lobar degeneration