title: [Fever and jaundice... and if it was a leptospirosis. About a case of L. interrogans icterohaemorrhagiae in Northern France].
abstract: Leptospirosis is an anthropozoonose, an animal disease transmissible to humans, caused by a spirochete of the genus Leptospira that lives mainly among rodents but also in wetlands. It occurs worldwide, particularly in Asia, Latin America and Africa. In Europe, the incidence is small (except in France and Great Britain, where its frequency has increased in recent years) but the frequency may be underestimated. Some areas overseas are particularly affected. In France, the potential epidemic of leptospirosis is subject to climatic variations, justifying a constant monitoring of the disease provided by the National Reference Centre (CNR) of leptospires. Transmission to humans primarily occurs through contact with environments contaminated by the urine of infected animals. The disease can affect the liver and kidneys (hepatonephritis) as cytolysis, cholestasis and renal failure associated with fever. A coagulopathy usually accompanies the clinical table. Its diagnosis is difficult because of the clinical polymorphism. Early diagnosis of leptospirosis allows effective medical care, improving patient outcomes. This is currently based on gene amplification (PCR) or serology positive by the microscopic agglutination test (MAT), which is the reference method. Its evolution is usually favorable with appropriate antibiotic treatment (aminopenicillin). However 5-10% of symptomatic patients have a severe multisystem defaillance. Nearly a century after the discovery of the causative agent, this zoonosis remains a public health problem, zoonosis priority in terms of virulence, its reporting is mandatory in our country. We report the case of a severe form of hepatonephritis due to water contaminated with Leptospira observed in Northern France.
authors.affiliation: Pôle de l'urgence, Samu régional de Lille, 5, avenue Oscar-Lambret, 59037 Lille cedex, France. natassez@yahoo.fr
authors.forename: N
authors.initials: N
authors.lastname: Assez
authors.forename: P
authors.initials: P
authors.lastname: Mauriaucourt
authors.forename: J
authors.initials: J
authors.lastname: Cuny
authors.forename: P
authors.initials: P
authors.lastname: Goldstein
authors.forename: E
authors.initials: E
authors.lastname: Wiel
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D000328:Adult; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D000822:Animal Husbandry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000175:diagnosis / Q000382:microbiology; D018450:Disease Progression; D004318:Doxycycline / Q000627:therapeutic use; D005334:Fever / Q000209:etiology; D005602:France / Q000453:epidemiology; D006801:Humans; D007159:Immunologic Tests; D007565:Jaundice / Q000209:etiology; D041383:Leptospira interrogans serovar icterohaemorrhagiae / Q000302:isolation & purification* / Q000472:pathogenicity; D008297:Male; D009784:Occupational Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015242:Ofloxacin / Q000627:therapeutic use; D051381:Rats; D006435:Renal Dialysis; D012756:Sheep; D013045:Species Specificity; D014871:Water Microbiology; D014876:Water Pollution; D014895:Weil Disease / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission; D015047:Zoonoses
chemical_list: D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination; D015242:Ofloxacin; D004318:Doxycycline