title: Serum visfatin levels and metabolic syndrome criteria in obese female subjects.
abstract: BACKGROUND
  Serum visfatin concentrations are associated with cardiovascular risk factors and obesity. Relation of this adipokine with metabolic syndrome is unclear. We decide to investigate the association between metabolic syndrome and visfatin levels in female obese subjects.
  
  
  METHODS
  A sample of 826 female obese subjects was analyzed. A complete nutritional and biochemical evaluation was performed. Serum visfatin levels were measured and to estimate the prevalence of metabolic syndrome, the definitions of the Adult Treatment Panel III was considered
  
  
  RESULTS
  Mean age was 48.1 + 12.6 years. Patients were divided in three groups by tertiles of visfatin value, group I (<7.94 ng/ml), group II (7.95-11.78 ng/ml) and group 3 (>11.79 ng/ml). A total of 350 women had metabolic syndrome (42.4%). Values of body mass index, weight, fat mass and waist circumference were lower in patients in the highest tertile group of visfatin than the lowest and middle tertiles of visfatin. Values of C reactive protein were higher in patients in the highest tertile group of visfatin than the lowest and middle tertiles of visfatin. Correlation analysis showed a significant correlation among serum visfatin levels and the independent variables; total cholesterol (r = 0.14;p < 0.05) and C reactive protein (r = 0.12;p < 0.05). In the multivariate analysis, only visfatin concentration increase 0.123 ng/ml (CI95%:0.033-0.445) for each mg/dl of C reactive protein.
  
  
  CONCLUSIONS
  Only C reactive protein remained associated in an independent way. Serum visfatin was not associated with the accumulation of metabolic syndrome factors or the diagnosis of metabolic syndrome in obese female subjects.
authors.affiliation: Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School and Unit of Investigation, University of Valladolid, Valladolid, Spain.
authors.forename: D A
authors.initials: DA
authors.lastname: de Luis
authors.forename: R
authors.initials: R
authors.lastname: Aller
authors.forename: M
authors.initials: M
authors.lastname: Gonzalez Sagrado
authors.forename: R
authors.initials: R
authors.lastname: Conde
authors.forename: O
authors.initials: O
authors.lastname: Izaola
authors.forename: B
authors.initials: B
authors.lastname: de la Fuente
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001837:Body Weights and Measures; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D004435:Eating / Q000502:physiology; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood* / Q000209:etiology*; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000150:complications; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human
keywords: females; metabolic syndrome; obesity; visfatin