title: Hepatoprotective phenolic glycosides from Gymnema tingens.
abstract: Six new phenolic diglycosides, named gymnetinosides A-F (1-6), were isolated from the ethanolic extract of Gymnema tingens, together with three known diglycosides, sequinoside K (7), khaephuoside B (8), and albibrissinoside A (9). The structures of the new compounds were determined by spectroscopic techniques including 1D-, 2D NMR, mass spectroscopy, and circular dichroism. Compounds 1, 5, and 6 showed hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Material Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors.forename: Jin
authors.initials: J
authors.lastname: Tian
authors.forename: Qin-Ge
authors.initials: QG
authors.lastname: Ma
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Yang
authors.forename: Ai-Guo
authors.initials: AG
authors.lastname: Wang
authors.forename: Teng-Fei
authors.initials: TF
authors.lastname: Ji
authors.forename: Yan-Gai
authors.initials: YG
authors.lastname: Wang
authors.forename: Ya-Lun
authors.initials: YL
authors.lastname: Su
mesh_terms: D002460:Cell Line / Q000187:drug effects; D002942:Circular Dichroism; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005688:Galactosamine / Q000633:toxicity; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D031103:Gymnema / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D020011:Protective Agents / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; D020011:Protective Agents; D005688:Galactosamine