title: The mitochondrial Italian Human Proteome Project initiative (mt-HPP).
abstract: Mitochondria carry maternally inherited genetic material, called the mitochondrial genome (mtDNA), which can be defined as the 25th human chromosome. The chromosome-centric Human Proteome Project (c-HPP) has initially focused its activities addressing the characterization and quantification of the nuclear encoded proteins. Following the last International HUPO Congress in Boston (September 2012) it was clear that however small the mitochondrial chromosome is, it plays an important role in many biological and physiopathological functions. Mutations in the mtDNA have been shown to be associated with dozens of unexplained disorders and the information contained in the mtDNA should be of major relevance to the understanding of many human diseases. Within this paper we describe the Italian initiative of the Human Proteome Project dedicated to mitochondria as part of both programs: chromosome-centric (c-HPP) and Biology/Disease (B/D-HPP). The mt-HPP has finally shifted the attention of the HUPO community outside the nuclear chromosomes with the general purpose to highlight the mitochondrial processes influencing the human health. Following this vision and considering the large interest and evidence collected on the non-Mendelian heredity of Homo sapiens associated with mt-chromosome and with the microbial commensal ecosystem constituting our organism we may speculate that this program will represent an initial step toward other HPP initiatives focusing on human phenotypic heredity.
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. andrea.urbani@uniroma2.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Urbani
authors.forename: Michele
authors.initials: M
authors.lastname: De Canio
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Palmieri
authors.forename: Salvatore
authors.initials: S
authors.lastname: Sechi
authors.forename: Luca
authors.initials: L
authors.lastname: Bini
authors.forename: Massimo
authors.initials: M
authors.lastname: Castagnola
authors.forename: Mauro
authors.initials: M
authors.lastname: Fasano
authors.forename: Alessandra
authors.initials: A
authors.lastname: Modesti
authors.forename: Paola
authors.initials: P
authors.lastname: Roncada
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Timperio
authors.forename: Luigi
authors.initials: L
authors.lastname: Bonizzi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Brunori
authors.forename: Francesca
authors.initials: F
authors.lastname: Cutruzzolà
authors.forename: Vito
authors.initials: V
authors.lastname: De Pinto
authors.forename: Carmine
authors.initials: C
authors.lastname: Di Ilio
authors.forename: Giorgio
authors.initials: G
authors.lastname: Federici
authors.forename: Franco
authors.initials: F
authors.lastname: Folli
authors.forename: Salvatore
authors.initials: S
authors.lastname: Foti
authors.forename: Cecilia
authors.initials: C
authors.lastname: Gelfi
authors.forename: Davide
authors.initials: D
authors.lastname: Lauro
authors.forename: Antonio
authors.initials: A
authors.lastname: Lucacchini
authors.forename: Fulvio
authors.initials: F
authors.lastname: Magni
authors.forename: Irene
authors.initials: I
authors.lastname: Messana
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Pandolfi
authors.forename: Sergio
authors.initials: S
authors.lastname: Papa
authors.forename: Piero
authors.initials: P
authors.lastname: Pucci
authors.forename: Paolo
authors.initials: P
authors.lastname: Sacchetta
mesh_terms: D002874:Chromosome Mapping; D002877:Chromosomes, Human; D015870:Gene Expression; D020869:Gene Expression Profiling; D015894:Genome, Human; D054629:Genome, Mitochondrial; D016045:Human Genome Project / Q000458:organization & administration*; D006801:Humans; D007558:Italy; D008928:Mitochondria / Q000235:genetics*; D020543:Proteome
chemical_list: D020543:Proteome