title: microRNA expression profiles in oral squamous cell carcinoma.
abstract: microRNAs (miRNAs) are involved in cancer pathogenesis, apoptosis and cell growth, thereby functioning as both tumor suppressors and oncogenes. However, the expression patterns and roles of miRNAs in oral squamous cell carcinoma (OSCC) remain largely unknown. We hypothesized that oral cancer may have a unique miRNA profile, which in turn may play a critical role in oral cancer development, progression, diagnosis and prognosis. We, therefore, investigated the expression profiles of 29 OSCC tumors and 7 normal oral mucosal samples. The miRNA expression patterns in OSCC were examined by TaqMan-based microRNA assays. We were subsequently able to identify the candidates of cancer-related miRNAs through analysis of the miRNA expression profiles. In conclusion, OSCC tissues were shown to have a unique miRNA profile pattern when compared with that in normal tissues. The present study may provide useful information for further investigation of the functional roles of miRNAs in OSCC development, progression, diagnosis and prognosis.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Ota-ku, Tokyo 145-8515, Japan. d-soga@dent.showa-u.ac.jp
authors.forename: Daisuke
authors.initials: D
authors.lastname: Soga
authors.forename: Sayaka
authors.initials: S
authors.lastname: Yoshiba
authors.forename: Sunao
authors.initials: S
authors.lastname: Shiogama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyazaki
authors.forename: Seiji
authors.initials: S
authors.lastname: Kondo
authors.forename: Satoru
authors.initials: S
authors.lastname: Shintani
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D009062:Mouth Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D059467:Transcriptome
chemical_list: D035683:MicroRNAs