title: Primary central nervous system lymphoma in immunocompetent individuals: a single center experience.
abstract: Primary central nervous system lymphoma (PCNSL) is defined as the involvement of brain, leptomeninges, eyes or spinal cord by non-Hodgkin lymphoma. The role of various prognostic markers in predicting adverse outcome is debated.
  
  
  OBJECTIVE
  To investigate the clinical and immunohistochemical findings of immunocompetent PCNSL cases (39 cases) diagnosed at the study center, and evaluate the influence of potential prognostic factors on overall survival (OS) of patients.
  
  
  METHODS
  Data regarding patient characteristics, neuroimaging, pathological and immunohistochemical features and follow-up were obtained from patient records. The influence of potential prognostic parameters on OS was investigated by log-rank test and Cox regression analysis.
  
  
  RESULTS
  Patients who received combined chemotherapy and radiotherapy had a significantly better OS when compared to chemotherapy alone. Other variables included in this study were not associated with a significant survival advantage.
  
  
  CONCLUSIONS
  In this study, we failed to demonstrate a relationship between different clinicopathological variables and OS of patients. Prospective studies with large patient series are needed to investigate other potential prognostic factors.
authors.affiliation: Department of Pathology, Istanbul University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey. hilal_aki@yahoo.com.tr
authors.forename: Hilal
authors.initials: H
authors.lastname: Aki
authors.forename: Didem
authors.initials: D
authors.lastname: Uzunaslan
authors.forename: Caner
authors.initials: C
authors.lastname: Saygin
authors.forename: Sebnem
authors.initials: S
authors.lastname: Batur
authors.forename: Nukhet
authors.initials: N
authors.lastname: Tuzuner
authors.forename: Ali
authors.initials: A
authors.lastname: Kafadar
authors.forename: Seniz
authors.initials: S
authors.lastname: Ongoren
authors.forename: Buge
authors.initials: B
authors.lastname: Oz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D016543:Central Nervous System Neoplasms / Q000276:immunology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D007121:Immunocompetence; D053208:Kaplan-Meier Estimate; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014421:Turkey; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor
keywords: PCNSL; Primary central nervous system lymphoma; immunocompetent; prognosis; survival