title: Transitions for regulating early transcription.
abstract: Gene expression is largely regulated during the initiation of RNA polymerase II (PolII) transcription. In this issue, Kouzine et al. show that control of DNA melting is one of the critical rate-limiting steps for productive mRNA elongation. We discuss these findings in the context of other key energetic transitions.
authors.affiliation: Gene Center Munich and Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.
authors.forename: Margaux
authors.initials: M
authors.lastname: Michel
authors.forename: Patrick
authors.initials: P
authors.lastname: Cramer
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism*; D011401:Promoter Regions, Genetic