title: [Study on correlation between neuropsychological features and Chinese medical syndrome types in patients with Wilson's disease].
abstract: OBJECTIVE
  To explore the correlation between neuropsychological features and Chinese medical syndrome types in Wilson's disease (WD) patients, thus providing evidence for early intervention by syndrome typing.
  
  
  METHODS
  Totally 96 WD patients were assigned to Gan-Dan damp-heat syndrome (GDDHS, 31 cases), Gan-Shen yin deficiency syndrome (GSYDS, 47 cases), and qi-blood deficiency syndrome (QBDS, 18 cases) by syndrome typing. Three items of neuropsychological testing were performed in them, i.e., Raven's standard progressive matrices (R'SPM), Stroop color-word test (CWT), trail making test (TMT). The correlations between the integrals of Chinese medical syndrome types and results of the 3 tests were analyzed.
  
  
  RESULTS
  (1) There was statistical difference in the total scores of R'SPM, the word interference time of CWT, and interference effects of TMT among the 3 syndrome types (P <0.01, P <0.05). There was statistical difference in the total scores of R'SPM and the word interference time of CWT in patients of QBDS, when compared with those of GDDHS and GSYDS (P <0.05). There was statistical difference in interference effects of TMT in patients of GDDHS, when compared with those of QBDS and GSYDS (P <0.05). (2) The integrals of the 3 syndrome types were negatively correlated with the total scores of R'SPM (P <0.01). The integral of GDDHS was significantly positively correlated with the interference effects of TMT (P <0.01). The integral of GSYDS was significantly positively correlated with TMT-B time consumption and interference effects of TMT (P <0. 05). The integral of QBDS was significantly positively correlated with the word interference time of CWT (P <0.05).
  
  
  CONCLUSIONS
  There was correlation between neuropsychological changes of WD patients and Chinese medical syndrome types. The severity of asthenia syndrome was sequenced from high to low as QBDS > GSYDS > GDDHS. The severity of asthenia was higher than that of asthenia.
authors.affiliation: Institute of Neurology, Anhui College of Traditional Chinese Medicine, Hefei 230061, China. wgq616@163.com
authors.forename: Gong-qiang
authors.initials: GQ
authors.lastname: Wang
authors.forename: Ming-shu
authors.initials: MS
authors.lastname: Wang
authors.forename: Guang-an
authors.initials: GA
authors.lastname: Tong
authors.forename: Dan-dan
authors.initials: DD
authors.lastname: Sun
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006527:Hepatolenticular Degeneration / Q000175:diagnosis* / Q000523:psychology*; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D009483:Neuropsychological Tests; D016711:Yang Deficiency / Q000175:diagnosis / Q000523:psychology; D016710:Yin Deficiency / Q000175:diagnosis / Q000523:psychology; D055815:Young Adult