title: Locally advanced head and neck cancer.
abstract: Treatment of locally advanced head and neck squamous cell carcinomas requires a multidisciplinary approach to be able to offer patients definitive therapy while aiming to preserve organ function and minimize acute and long-term toxicities. Advances in surgical techniques will be reviewed for both primary sites and the neck and also in the salvage settings. Recent data on concurrent versus sequential chemoradiotherapy in these patients will be reviewed, with emphasis on identification of appropriate patients for sequential chemoradiotherapy. Finally, advances in modern radiotherapy modalities that have resulted in improved dosimetry and quality of life following treatment will be reviewed.
authors.affiliation: From the Vanderbilt-Ingram Cancer Center, Nashville, TN; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; University of Toronto, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Cmelak
authors.forename: Kyle
authors.initials: K
authors.lastname: Arneson
authors.forename: Nicole G
authors.initials: NG
authors.lastname: Chau
authors.forename: Ralph W
authors.initials: RW
authors.lastname: Gilbert
authors.forename: Robert I
authors.initials: RI
authors.lastname: Haddad
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001918:Brachytherapy / Q000379:methods; D059248:Chemoradiotherapy / Q000379:methods*; D019583:Dose Fractionation, Radiation; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D007830:Larynx / Q000473:pathology / Q000601:surgery; D009959:Oropharyngeal Neoplasms / Q000473:pathology / Q000628:therapy; D009960:Oropharynx / Q000473:pathology / Q000601:surgery; D061766:Proton Therapy / Q000379:methods; D011788:Quality of Life; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods; D016879:Salvage Therapy; D016896:Treatment Outcome