title: Accuracy of sentinel node biopsy in esophageal carcinoma: a systematic review and meta-analysis of the pertinent literature.
abstract: The use of sentinel node surgery for esophageal carcinoma is still under investigation. We evaluated the data available in the literature on this topic, and herein present the results in a systematic review format. PUBMED, SCOPUS, the ISI web of knowledge and the information from the annual meetings of the Japan Esophageal Society were searched using the search terms: "(esophagus OR esophageal) AND sentinel". The outcomes of interest were the detection rate and sensitivity. Overall, 18 studies were included. The pooled detection rate was 89.2% [82.6-93.5]. Patients with T1 and two tumors had a 17% higher detection rate compared to those with T3 and four tumors. The pooled sensitivity was 84% [78-88%]. The sensitivity was higher for adenocarcinoma compared to squamous cell carcinoma (SCC) (91 vs. 81%). In the SCC patients, there was a trend toward decreased sensitivity associated with an increasing tumor depth (T1:88%, T2:76%, T3:50%). Our analysis indicated that sentinel node biopsy is useful in adenocarcinoma patients. For SCC patients, including only cN0 patients (preferably T1 and 2) would increase the detection rate and sensitivity. Due to the limited number of high-quality studies, drawing any more definite conclusions is impossible. Large cohort studies with a standardized and consistent design will be needed in the future.
authors.affiliation: Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Vahid Reza
authors.initials: VR
authors.lastname: Dabbagh Kakhki
authors.forename: Reza
authors.initials: R
authors.lastname: Bagheri
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Tehranian
authors.forename: Pardis
authors.initials: P
authors.lastname: Shojaei
authors.forename: Hassan
authors.initials: H
authors.lastname: Gholami
authors.forename: Ramin
authors.initials: R
authors.lastname: Sadeghi
authors.forename: David N
authors.initials: DN
authors.lastname: Krag
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D005188:False Negative Reactions; D039781:PubMed; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy; D014410:Tumor Stem Cell Assay