title: Design, synthesis and evaluation of dual-modality glyco-nanoparticles for tumor imaging.
abstract: d-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (111In). The resultant nano-scale tumor-targeting imaging tracer, 111In-DG-NIRF-CCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis.
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Lin
authors.forename: Ye
authors.initials: Y
authors.lastname: Hong
authors.forename: Chun
authors.initials: C
authors.lastname: Li
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005944:Glucosamine / Q000737:chemistry*; D064593:Heterografts; D006801:Humans; D007553:Isotope Labeling; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D005944:Glucosamine