title: Regulation of self-ligands for activating natural killer cell receptors.
abstract: Natural killer (NK) cells are able to lyse infected and tumor cells while sparing healthy cells. Recognition of diseased cells by NK cells is governed by several activating and inhibitory receptors. We review numerous pathways that have been implicated in the regulation of self-ligands for activating receptors, including NKG2D, DNAM-1, LFA-1, NKp30, NKp44, NKp46, NKp65, and NKp80 found on NK cells and some T cells. Understanding how the regulation of self-encoded ligand expression is regulated may provide novel avenues for future therapeutic approaches to infections and cancer.
authors.affiliation: Immunology Programme, Centre for Life Sciences, Department of Microbiology, National University of Singapore 117456, Singapore.
authors.forename: Runyi A
authors.initials: RA
authors.lastname: Lam
authors.forename: Jyh Y
authors.initials: JY
authors.lastname: Chwee
authors.forename: Nina
authors.initials: N
authors.lastname: Le Bert
authors.forename: Maike
authors.initials: M
authors.lastname: Sauer
authors.forename: Elke
authors.initials: E
authors.lastname: Pogge von Strandmann
authors.forename: Stephan
authors.initials: S
authors.lastname: Gasser
mesh_terms: D003602:Cytotoxicity, Immunologic / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism*; D008024:Ligands; D055607:Receptors, Natural Killer Cell / Q000276:immunology* / Q000378:metabolism*
chemical_list: D008024:Ligands; D055607:Receptors, Natural Killer Cell