title: Clinical characteristics of patients with multiple potentially human papillomavirus-related malignancies.
abstract: BACKGROUND
  Human papillomavirus (HPV) is a causative factor in squamous cell carcinomas of the anus, penis, vagina, vulva, and head and neck, and adenocarcinoma of the cervix. We examined the demographics, clinical characteristics, and timing of multiple potentially HPV-related cancers in individual patients.
  
  
  METHODS
  One hundred forty-three patients were identified with 300 potentially HPV-related cancers. The median follow-up from index and second cancer was 18.5 years and 3.2 years, respectively.
  
  
  RESULTS
  Median age at index and second cancer was 45 and 60.5 years of age, respectively, with a median interval of 11 years. Cervical cancer was the most common initial diagnosis (61.7%), whereas head and neck squamous cell carcinoma (HNSCC) was the most common second cancer (57.6%).
  
  
  CONCLUSIONS
  These data suggest differential patterns for development of multiple HPV-related cancers based upon clinical characteristics. Prospective longitudinal and population-based studies are warranted to understand the impact of these findings and opportunities for intervention and screening.
authors.affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Heath D
authors.initials: HD
authors.lastname: Skinner
authors.forename: Erich M
authors.initials: EM
authors.lastname: Sturgis
authors.forename: Ann H
authors.initials: AH
authors.lastname: Klopp
authors.forename: Kie-Kian
authors.initials: KK
authors.lastname: Ang
authors.forename: David I
authors.initials: DI
authors.lastname: Rosenthal
authors.forename: Adam S
authors.initials: AS
authors.lastname: Garden
authors.forename: William H
authors.initials: WH
authors.lastname: Morrison
authors.forename: G Brandon
authors.initials: GB
authors.lastname: Gunn
authors.forename: Beth M
authors.initials: BM
authors.lastname: Beadle
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D001005:Anus Neoplasms / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D015994:Incidence; D008297:Male; D016347:Medical Records Systems, Computerized; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology*; D010412:Penile Neoplasms / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D014625:Vaginal Neoplasms / Q000453:epidemiology; D014846:Vulvar Neoplasms / Q000453:epidemiology
keywords: HPV; anal cancer; cervical cancer; oropharynx cancer; second cancer screening