title: Autophagy proteins regulate cell engulfment mechanisms that participate in cancer.
abstract: Recent evidence has uncovered cross-regulation of mechanisms of cell engulfment by proteins of the autophagy pathway, in what is called LC3-Associated Phagocytosis, or LAP. By LAP, lysosome fusion to phagosomes and the degradation of engulfed extracellular cargo are facilitated by autophagy proteins that lipidate LC3 onto phagosome membranes. Here we discuss the contexts where LAP is known to occur by focusing on potential roles in tumorigenesis, including predicted consequences of LAP inhibition.
authors.affiliation: BCMB Allied Program, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA; Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Kim
authors.forename: Michael
authors.initials: M
authors.lastname: Overholtzer
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D010587:Phagocytosis / Q000502:physiology; D010588:Phagosomes / Q000378:metabolism / Q000473:pathology; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins
keywords: Autophagy; Cell death; Entosis; Immune; Macrophage; Phagocytosis; Tumor