title: Novel molecular type of Clostridium difficile in neonatal pigs, Western Australia.
abstract: Clostridium difficile causes neonatal enteritis in piglets; strains of PCR ribotype 078 are most commonly identified. We investigated C. difficile prevalence in piglets in Australia and isolated a novel strain with a unique pathogenicity locus. In a mouse infection model, this strain produced more weight loss than did a ribotype 078 strain.
authors.affiliation: The University of Western Australia, Nedlands, Western Australia, Australia.
authors.forename: Michele M
authors.initials: MM
authors.lastname: Squire
authors.forename: Glen P
authors.initials: GP
authors.lastname: Carter
authors.forename: Kate E
authors.initials: KE
authors.lastname: Mackin
authors.forename: Anjana
authors.initials: A
authors.lastname: Chakravorty
authors.forename: Torbjörn
authors.initials: T
authors.lastname: Norén
authors.forename: Briony
authors.initials: B
authors.lastname: Elliott
authors.forename: Dena
authors.initials: D
authors.lastname: Lyras
authors.forename: Thomas V
authors.initials: TV
authors.lastname: Riley
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000096:biosynthesis; D001427:Bacterial Toxins / Q000096:biosynthesis; D016360:Clostridioides difficile / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality / Q000662:veterinary*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016133:Polymerase Chain Reaction / Q000662:veterinary; D015995:Prevalence; D021521:Ribotyping / Q000662:veterinary; D016019:Survival Analysis; D013552:Swine / Q000382:microbiology*; D014904:Western Australia / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001427:Bacterial Toxins; C031815:toxB protein, Clostridium difficile
keywords: Australia; C. difficile; Cdiff; Clostridium difficile; DNA; PCR; animals; bacteria; diarrhea; domestic; enteritis; piglets; pigs; prevalence; ribotyping; sequence analysis; veterinary; zoonoses