title: Immune and inflammatory role in renal disease.
abstract: Chronic and acute renal diseases, irrespective of the initiating cause, have inflammation and immune system activation as a common underlying mechanism. The purpose of this review is to provide a broad overview of immune cells and inflammatory proteins that contribute to the pathogenesis of renal disease, and to discuss some of the physiological changes that occur in the kidney as a result of immune system activation. An overview of common forms of acute and chronic renal disease is provided, followed by a discussion of common therapies that have anti-inflammatory or immunosuppressive effects in the treatment of renal disease.
authors.affiliation: Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. jdimig@mcw.edu
authors.forename: John D
authors.initials: JD
authors.lastname: Imig
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Ryan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D006801:Humans; D007113:Immunity, Innate; D007155:Immunologic Factors / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D007674:Kidney Diseases / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000893:Anti-Inflammatory Agents; D007155:Immunologic Factors