title: Hour-specific nomogram for transcutaneous bilirubin in Japanese neonates.
abstract: BACKGROUND
  The measurement of transcutaneous bilirubin (TcB) is very important to screen for hyperbilirubinemia in newborns. Until now, however, there has been no hour-specific, percentile-based TcB nomogram during the early neonatal period in Japanese neonates. The aim of this study was to develop a TcB nomogram within 72 h of birth in Japanese neonates.
  
  
  METHODS
  A total of 3152 TcB measurements for 181 healthy Japanese neonates (gestational age ≥36 weeks, birthweight ≥2300 g) were obtained within 72 h of birth. All measurements were performed with a Konica Minolta jaundice meter, the JM-103. A nomogram curve was plotted to show the trend of TcB level over time.
  
  
  RESULTS
  The nomogram curves rose almost linearly for all percentiles until 72 h after birth.
  
  
  CONCLUSIONS
  An hour-specific, percentile-based TcB nomogram during the first 72 h after birth in Japanese neonates was successfully developed. Because Japanese neonates have higher and later peak bilirubin, an original hour-specific 97.5th percentile-based TcB nomogram may be needed to identify early-onset jaundice and manage neonatal hyperbilirubinemia.
authors.affiliation: Maternal Perinatal Center, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Kuboi
authors.forename: Takashi
authors.initials: T
authors.lastname: Kusaka
authors.forename: Koh
authors.initials: K
authors.lastname: Kawada
authors.forename: Kousuke
authors.initials: K
authors.lastname: Koyano
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakamura
authors.forename: Kensuke
authors.initials: K
authors.lastname: Okubo
authors.forename: Saneyuki
authors.initials: S
authors.lastname: Yasuda
authors.forename: Kenichi
authors.initials: K
authors.lastname: Isobe
authors.forename: Susumu
authors.initials: S
authors.lastname: Itoh
mesh_terms: D001663:Bilirubin / Q000032:analysis*; D005260:Female; D005865:Gestational Age; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000208:ethnology* / Q000378:metabolism; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D008297:Male; D015997:Neonatal Screening / Q000379:methods*; D049451:Nomograms; D044469:Racial Groups; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D001663:Bilirubin
keywords: JM-103; early-onset jaundice; neonatal hyperbilirubinemia; percentile-based; race