title: Emerging therapies for rheumatoid arthritis.
abstract: BACKGROUND
  With the introduction of biologic therapies, tremendous progress has been made in the treatment of rheumatoid arthritis (RA). However, up to 40% of patients do not respond to these treatments.
  
  
  METHODS
  Several new treatment strategies are discussed, with brief overview of currently performed clinical trials. The development of molecules targeting cytokines other than TNF is discussed, as well as chemokine-directed drugs. Finally, the area of small molecular inhibitors is explored.
  
  
  CONCLUSIONS
  Since RA is a life-long disease often evolving into disability, development of new treatment strategies remains crucial. Especially small molecules targeting JAK, Syk and PDE4 may provide novel therapeutic options.
authors.affiliation: Ghent University Hospital, Department of Rheumatology, De Pintelaan 185, Gent, Belgium.
authors.forename: Peggy
authors.initials: P
authors.lastname: Jacques
authors.forename: Filip
authors.initials: F
authors.lastname: Van den Bosch
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D047428:Protein Kinase Inhibitors