title: One-pot synthesis of novel chiral β-amino acid derivatives by enantioselective Mannich reactions catalyzed by squaramide cinchona alkaloids.
abstract: An efﬁcient one-pot synthesis of novel β-amino acid derivatives containing a thiadiazole moiety was developed using a chiral squaramide cinchona alkaloid as organocatalyst. The reactions afforded chiral β-amino acid derivatives in moderate yields and with moderate to excellent enantioselectivities. The present study demonstrated for the first time the use of a Mannich reaction catalyzed by a chiral bifunctional organocatalyst for the one-pot synthesis of novel β-amino acid derivatives bearing a 1,3,4-thiadiazole moiety on nitrogen.
authors.affiliation: State Key Laboratory of Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China.
authors.forename: Kankan
authors.initials: K
authors.lastname: Zhang
authors.forename: Xueping
authors.initials: X
authors.lastname: Liang
authors.forename: Ming
authors.initials: M
authors.lastname: He
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Yuping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Xue
authors.forename: Linhong
authors.initials: L
authors.lastname: Jin
authors.forename: Song
authors.initials: S
authors.lastname: Yang
authors.forename: Deyu
authors.initials: D
authors.lastname: Hu
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D002930:Cinchona Alkaloids / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000596:Amino Acids; D002930:Cinchona Alkaloids