title: Visible-light optical coherence tomography for retinal oximetry.
abstract: We applied a visible-light spectroscopic optical coherence tomography (vis-OCT) for in vivo retinal oximetry. To extract hemoglobin oxygen saturation (sO(2)) in individual retinal vessels, we established a comprehensive analytical model to describe optical absorption, optical scattering, and blood cell packing factor in the whole blood and fit the acquired vis-OCT signals from the bottom of each imaged vessel. We found that averaged sO(2) values in arterial and venous bloods were 95% and 72%, respectively.
authors.affiliation: Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA.
authors.forename: Ji
authors.initials: J
authors.lastname: Yi
authors.forename: Qing
authors.initials: Q
authors.lastname: Wei
authors.forename: Wenzhong
authors.initials: W
authors.lastname: Liu
authors.forename: Vadim
authors.initials: V
authors.lastname: Backman
authors.forename: Hao F
authors.initials: HF
authors.lastname: Zhang
mesh_terms: D000042:Absorption; D001808:Blood Vessels / Q000378:metabolism; D006801:Humans; D008027:Light; D055620:Optical Phenomena; D010092:Oximetry / Q000379:methods*; D012160:Retina / Q000378:metabolism; D041623:Tomography, Optical Coherence / Q000379:methods*