title: Side chain and backbone structure-dependent subcellular localization and toxicity of conjugated polymer nanoparticles.
abstract: The subcellular localization and toxicity of conjugated polymer nanoparticles (CPNs) are dependent on the chemical structure of the side chains and backbone. Primary amine-containing CPNs exhibit high Golgi localization with no toxicity. Incorporation of short ethylene oxide and tertiary amine side chains contributes to decreased Golgi localization and increased toxicity, respectively.
authors.affiliation: Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th St., Miami, FL 33199, USA.
authors.forename: Eladio
authors.initials: E
authors.lastname: Mendez
authors.forename: Joong Ho
authors.initials: JH
authors.lastname: Moon
mesh_terms: D000588:Amines / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D005027:Ethylene Oxide / Q000737:chemistry; D006056:Golgi Apparatus / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D011108:Polymers / Q000737:chemistry*
chemical_list: D000588:Amines; D011108:Polymers; D005027:Ethylene Oxide