title: [Cyclic nucleotide-gated channels and sperm function].
abstract: The cyclic nucleotide-gated (CNG) channel is a nonselective cation channel and one of the main entrances of Ca2+ influxion into cells. CNG channels are opened by direct binding of cyclic nucleotides. Six different genes encode the CNG protein, 4 A subunits and 2 B subunits. The activity of CNG channels can be regulated by Ca2+/Ca(2+)-binding proteins (CaM) and phosphorylation/dephosphorylation. Recently, extensive attention has been drawn to the researches on CNG channels in the reproductive system, and many studies show that CNG channels play a pivotal role in sperm motility, capacitation and acrosome reaction. This article focuses on the relationship of CNG channels with sperm function.
authors.affiliation: Department of Reproductive Biology, Shanghai Institute of Planned Parenthood Research, NPFPC Laboratory of Contraception and Devices, Shanghai 200032, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Du
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000502:physiology*; D006801:Humans; D008297:Male; D013094:Spermatozoa / Q000378:metabolism / Q000502:physiology
chemical_list: D054815:Cyclic Nucleotide-Gated Cation Channels; D002118:Calcium