title: Effects of polygonum cuspidatum containing resveratrol on inflammation in male professional basketball players.
abstract: BACKGROUND
  Exercise can lead to acute oxidative stress, which can result in oxidative damage and induce inflammation. Resveratrol may reduce the levels of inflammatory cytokines. Thus, we investigated the effects of this compound on the plasma levels of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) in male professional basketball players.
  
  
  METHODS
  Twenty healthy male professional basketball players were randomized into two groups (10 each). For 6 weeks, they received daily either 200 mg of polygonum cuspidatum extract (PCE) standardized to contain 20% trans-resveratrol equivalent to 40 mg trans-resveratrol or placebo. Indices of inflammation were measured before and after 6 weeks of supplementation.
  
  
  RESULTS
  There was a significant reduction in plasma levels of TNF-a and IL-6 after 6 weeks of supplementation; while no change was observed in these markers in the control group.
  
  
  CONCLUSIONS
  Present study shows that 6 weeks of PCE containing resveratrol supplementation reduces the inflammation in male professional basketball players.
authors.affiliation: Department of Clinical Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences, Iran ; Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Iran.
authors.forename: Hoda Sadat
authors.initials: HS
authors.lastname: Zahedi
authors.forename: Shima
authors.initials: S
authors.lastname: Jazayeri
authors.forename: Reza
authors.initials: R
authors.lastname: Ghiasvand
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Djalali
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Eshraghian
keywords: Cytokines; inflammation; interleukin-6; polygonum cuspidatum; resveratrol; tumor necrosis factor-α