title: A modified two-stage approach for family-based genome-wide association studies.
abstract: Genome-wide association studies can provide researchers some reference on gene mapping of complex trait, a key point of which is how to improve the power of association test. Recently, two-stage approaches are widely used to genome-wide association analysis. In the first stage, a screening test is used to select markers, and in the second stage, a family-based association test is performed based on a smaller set of the selected markers. Here, we modify an existing two-stage approach and propose a new test statistic for the association analysis. Simulation studies are conducted to compare the type I error rates and powers of the proposed approach with those of the existing two-stage approaches. Simulation results show that the new two-stage approach has greater power than the other two-stage approaches to some extent.
authors.affiliation: Department of Statistics, School of Mathematical Sciences, Heilongjiang University, Harbin, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Ma
authors.affiliation: Department of Statistics, School of Mathematical Sciences, Heilongjiang University, Harbin, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Statistics, School of Mathematical Sciences, Heilongjiang University, Harbin, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Statistics, School of Mathematical Sciences, Heilongjiang University, Harbin, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Basic Research, East University of Heilongjiang, Harbin, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gu
mesh_terms: D003198:Computer Simulation; D005819:Genetic Markers; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D008957:Models, Genetic; D010375:Pedigree
chemical_list: D005819:Genetic Markers