title: Immunomodulatory effect of cimetidine in common carp (Cyprinus carpio L.).
abstract: The main indication of cimetidine is being H₂-receptor antagonist, but studies suggest that cimetidine may also act as a non-specific stimulant of cell-mediated immunity and immunomodulator. In order to determine the immunomodulatory effect of dietary intake of cimetidine in the common carp (100 ± 10 g), subjects were fed diets containing 0 (control), 50, 100 and 200 mg cimetidine kg⁻¹ of dry diet for a period of 6 weeks. TLC and NBT assays were significantly (P < 0.05) stimulated in cimetidine-supplemented groups displaying the highest value in 200 mg kg⁻¹ group. A decrease (P < 0.05) in cortisol and ACH50 value was recorded in fish treated with cimetidine. Serum protein, albumin and serum globulin levels were not significantly changed. The findings of the present investigation suggest that the incorporation of cimetidine in the diet of common carp enhances the non-specific immunity.
authors.affiliation: Department of Fisheries, Islamic Azad University, Babol Branch, Babol, Iran.
authors.forename: Seyyed Mehdi
authors.initials: SM
authors.lastname: Hosseinifard
authors.forename: Asieh
authors.initials: A
authors.lastname: Ahmadpour
authors.forename: Bagher
authors.initials: B
authors.lastname: Mojazi Amiri
authors.forename: Majid
authors.initials: M
authors.lastname: Razeghi Mansour
authors.forename: Arezo
authors.initials: A
authors.lastname: Ebrahimpour
mesh_terms: D000818:Animals; D002347:Carps / Q000276:immunology*; D002927:Cimetidine / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D007107:Immune System / Q000187:drug effects*; D011897:Random Allocation
chemical_list: D006635:Histamine H2 Antagonists; D002927:Cimetidine