title: [Antisynthetase syndrome and lung carcinoma: a fortuitous association?].
abstract: BACKGROUND
  Dermatomyositis and polymyositis are sometimes associated with neoplasia. Conversely, a link between antisynthetase syndrome and neoplasia has not been clearly demonstrated.
  
  
  METHODS
  We report a 54-year-old smoker male patient who presented with an antisynthetase syndrome with anti-Jo1 and anti-Ro-52 antibodies. An adenocarcinoma of the lung was diagnosed at the same time.
  
  
  CONCLUSIONS
  Two recent studies showed that patients with an antisynthetase syndrome associated with anti-Jo1 antibodies have more severe prognosis than antisynthetase syndrome associated with other antibodies (i.e. PL7/PL12). The risk of cancer occurrence seems to be increased when the anti-Jo1 antisynthetase syndrome is associated with anti-Ro-52 antibodies. To date, there is no demonstrated association between antisynthetase syndrome and neoplasia.
authors.affiliation: Service de médecine interne et rhumatologie, hôpital de la Croix-Saint-Simon, 125, rue d'Avron, 75020 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Courties
authors.affiliation: Service de médecine interne et rhumatologie, hôpital de la Croix-Saint-Simon, 125, rue d'Avron, 75020 Paris, France. Electronic address: olidove@hopital-dcss.org.
authors.forename: O
authors.initials: O
authors.lastname: Lidove
authors.affiliation: Institut de myologie, hôpital de la Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: T
authors.initials: T
authors.lastname: Maisonobe
authors.affiliation: Service de médecine interne 1, hôpital de la Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Rigolet
authors.affiliation: Service de médecine interne et rhumatologie, hôpital de la Croix-Saint-Simon, 125, rue d'Avron, 75020 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Hermet
authors.affiliation: Département de pneumologie, institut mutualiste Montsouris, 42, boulevard Jourdan, 75014 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Girard
authors.affiliation: Service de médecine interne et rhumatologie, hôpital de la Croix-Saint-Simon, 125, rue d'Avron, 75020 Paris, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Ziza
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D000077192:Adenocarcinoma of Lung; D000974:Antibodies, Antinuclear / Q000097:blood; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D000974:Antibodies, Antinuclear; C046750:Jo-1 antibody
keywords: Anti-Ro-52 antibodies; Anticorps anti-Ro-52; Antisynthetase syndrome; Cancer; Neoplasia; Syndrome des antisynthétases