title: Chromatin: a tail of repression.
abstract: Genetic evidence on the role of specific histone amino acids or their posttranslational modifications in metazoan development has been lacking. A recent study reports that fruit flies carrying histone H3 lysine 27 (H3K27) mutations have the same homeotic gene expression and developmental defects as mutations in the enzyme that trimethylates H3K27.
authors.affiliation: Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. danesh_moazed@hms.harvard.edu
authors.forename: Danesh
authors.initials: D
authors.lastname: Moazed
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics*; D005786:Gene Expression Regulation; D006657:Histones / Q000235:genetics* / Q000378:metabolism*; D063151:Polycomb Repressive Complex 2 / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D006657:Histones; D063151:Polycomb Repressive Complex 2