title: Normalization of creatine kinase values in a case of rhabdomyolysis during daptomycin treatment.
abstract: A 41-year-old woman presented in the Emergency Department with suspected compartment syndrome of lower left leg (creatine kinase [CK]: 12,502 IU/L, Cr: 4.31 mg/dL). Fasciotomy of the four limb compartments was conducted. By day 2, the patient presented oliguria during previous 24 h, so daily intermittent dialysis was carried out. On day 12, the patient presented an episode of bacteremia due to Staphylococcus hominis. Treatment with vancomycin was initiated and was changed after 4 days to daptomycin due to unsatisfactory clinical progression (6 mg/kg every 48 h, according to renal function and patient's weight) (CK: 2,972 IU/L). After 15 days of treatment, the dose of daptomycin was increased to 6 mg/kg every 24 h (CrCL: 46 mL/min, CK: 83 IU/L). The antibiotic was continued for another 4 days. Fourteen days later, the patient was discharged (CK: 26 IU/L). Daptomycin could be prescribed in some patients with elevated CK values. A cut-off value of baseline CK for use of daptomycin needs to be determined.
authors.affiliation: Department of Pharmacy, Hospital Universitari del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Olivia
authors.initials: O
authors.lastname: Ferrández
authors.forename: Olatz
authors.initials: O
authors.lastname: Urbina
authors.forename: Sònia
authors.initials: S
authors.lastname: Luque
authors.forename: Mercè
authors.initials: M
authors.lastname: Espona
authors.forename: Nuria
authors.initials: N
authors.lastname: Berenguer
authors.forename: Santiago
authors.initials: S
authors.lastname: Grau
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016470:Bacteremia / Q000188:drug therapy*; D003402:Creatine Kinase / Q000097:blood; D017576:Daptomycin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D012206:Rhabdomyolysis / Q000188:drug therapy* / Q000201:enzymology; D013203:Staphylococcal Infections / Q000188:drug therapy*; D041181:Staphylococcus hominis / Q000302:isolation & purification; D016896:Treatment Outcome; D014640:Vancomycin / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D003402:Creatine Kinase; D017576:Daptomycin
keywords: Creatine kinase; daptomycin; rhabdomyolysis