title: Do we need to consider ethno-cultural variation in the use of atypical antipsychotics for Asian patients with major depressive disorder?
abstract: Asian and western countries differ in the prevalence, symptom manifestation, diagnostic procedures, patient recognition and treatments of major depressive disorder (MDD), according to a number of studies. Ethnic differences in pharmacological profiles are also important in the prescription of certain antipsychotic medications because they may impact treatment outcomes and adverse events. Differential pharmacokinetic and pharmacodynamic properties of antipsychotics may be practically useful in the control of specific depressive symptoms. Furthermore, patient compliance with prescribed medications has been found to be different across races and ethnicities. Therefore, this article explores practical clinical issues for the use of atypical antipsychotics in patients with MDD, focusing on ethno-cultural differences.
authors.affiliation: Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.
authors.forename: Changsu
authors.initials: C
authors.lastname: Han
authors.forename: Chi-Un
authors.initials: CU
authors.lastname: Pae
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D044466:Asian People / Q000523:psychology*; D003469:Culture; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000208:ethnology*; D006801:Humans; D010349:Patient Compliance / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents