title: The adipokines and inflammatory marker in young type 2 diabetics with metabolic syndrome: A pilot study.
abstract: OBJECTIVE
  The purpose of the metabolic syndrome (MetS) concept was to early identify subjects having risk for developing cardiovascular diseases and diabetes, which of both are involved in low grade inflammation and obesity. We wish to explore the role of adipokines and inflammatory marker in young type 2 diabetics (YDM) with MetS.
  
  
  METHODS
  Forty-eight YDM patients were divided to 2 and 3 groups according to the presence of the MetS (MetS+ and MetS-), and the numbers of MetS component (MetS-2 to MetS-4 with 1-2, 3, and 4-5 components) respectively. Plasma adipokines (tumor necrosis factor-α; TNF-α and adiponectin) and C-reactive protein (CRP) were measured and compared among groups.
  
  
  RESULTS
  Blood pressure (BP), body mass index (BMI), and plasma triglyceride (TG) levels were higher in the group with MetS+ than that of MetS-. Except for diastolic BP, BMI, waist, and plasma TG levels, which were generally lower in the MetS-2 group, the rest demographic characteristics were not different among these three groups. Finally, the plasma adiponectin, CRP and TNF-αlevels were not different between both groups with or without MetS; and also among these three groups regardless the component numbers they had.
  
  
  CONCLUSIONS
  YDM with MetS might have non-significant lower adiponectin and higher CRP levels compared to subjects without MetS. It needs prospective study with larger scale to explicit the role of cytokines and inflammatory markers in YDM with MetS.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan, ROC.
authors.forename: Min-Jie
authors.initials: MJ
authors.lastname: Wen
authors.forename: Chang-Hsun
authors.initials: CH
authors.lastname: Hsieh
authors.forename: Chung-Ze
authors.initials: CZ
authors.lastname: Wu
authors.forename: Fone-Ching
authors.initials: FC
authors.lastname: Hsiao
authors.forename: Te-Lin
authors.initials: TL
authors.lastname: Hsia
authors.forename: Yi-Jen
authors.initials: YJ
authors.lastname: Hung
authors.forename: Dee
authors.initials: D
authors.lastname: Pei
mesh_terms: D054392:Adipokines / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D018836:Inflammation Mediators / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D010865:Pilot Projects; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D014280:Triglycerides; D055815:Young Adult
chemical_list: D054392:Adipokines; D015415:Biomarkers; D018836:Inflammation Mediators; D014280:Triglycerides; D002097:C-Reactive Protein