title: Effects of clonazepam on self-induced photoparoxysmal responses.
abstract: A 5-year-old girl exhibited daily episodes of repetitive blinking lasting 5-10 s. Electroencephalography (EEG) revealed marked photoparoxysmal responses (PPR) at 3-20 Hz of photic stimulation and diffuse spike-wave bursts during sleep. A 24-h video EEG identified 11 episodes of repetitive blinking, 3 of which resulted in widespread spike-wave discharges. These suggested that the behavior of the patient represented self-induction of PPR. Valproate sodium was ineffective in decreasing PPR, as revealed by EEG, and the frequency of blinking episodes, but clonazepam attenuated PPR and significantly decreased the blinking behavior.
authors.affiliation: Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan. Electronic address: saitoyo@ncnp.go.jp.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Saito
authors.affiliation: Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Matsuda
authors.affiliation: Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugai
authors.affiliation: Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Nakagawa
authors.affiliation: Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Ishiyama
authors.affiliation: Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Saito
authors.affiliation: Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Hiforumi
authors.initials: H
authors.lastname: Komaki
authors.affiliation: Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sasaki
authors.affiliation: Saiwai Child Clinic, Tokyo, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Miyata
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D001767:Blinking / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D002675:Child, Preschool; D002998:Clonazepam / Q000627:therapeutic use*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D010775:Photic Stimulation; D010787:Photosensitivity Disorders / Q000188:drug therapy* / Q000503:physiopathology; D012890:Sleep / Q000502:physiology; D016896:Treatment Outcome; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D002998:Clonazepam; D014635:Valproic Acid
keywords: Blinking; Eyelid; Photoparoxysmal response; Photosensitivity; Self-induction