title: The difference of neovascularization in early intra-alveolar fibrosis between nonspecific interstitial pneumonia and usual interstitial pneumonia.
abstract: Of the idiopathic interstitial pneumonias (IIPs), usual interstitial pneumonia (UIP) and diffuse alveolar damage (DAD) usually have poor prognoses. The prognoses of cryptogenic organizing pneumonia (COP) and nonspecific interstitial pneumonia (NSIP) are usually more favorable. Although several reports have described neovascularization in COP and UIP, this aspect of UIP has not been compared with NSIP. In this study, we evaluated neovascularization in intra-alveolar fibrotic lesion of cases of fibrosing NSIP (f-NSIP) (n = 26) and UIP (n = 25). In the f-NSIP group, a considerable degree of neovascularization was observed compared to the UIP group and bud type intra-alveolar fibrosis showed a greater degree of neovascularization compared to the mural-incorporation and obliterative types of intra-alveolar fibrosis. Real-time reverse transcription polymerase chain reaction revealed a significantly greater expression of VEGF-A mRNA in f-NSIP than in UIP. The expression of matrix metalloproteinase-2 (MMP-2) mRNA also showed significantly higher in f-NSIP than UIP. The greater VEGF-A and MMP-2 expression may play a role in the pathogenesis of neovascularization in early intra-alveolar fibrotic lesions in f-NSIP.
authors.affiliation: Department of Analytic Human Pathology, Nippon Medical School, Tokyo 113-8602, Japan. onomk@nms.ac.jp
authors.forename: Mikiko
authors.initials: M
authors.lastname: Takahashi
authors.forename: Shinobu
authors.initials: S
authors.lastname: Kunugi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Terasaki
authors.forename: Mika
authors.initials: M
authors.lastname: Terasaki
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Urushiyama
authors.forename: Naomi
authors.initials: N
authors.lastname: Kuwahara
authors.forename: Kyoko
authors.initials: K
authors.lastname: Wakamatsu
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakayama
authors.forename: Yuh
authors.initials: Y
authors.lastname: Fukuda
mesh_terms: D018549:Cryptogenic Organizing Pneumonia / Q000473:pathology; D005109:Extracellular Matrix; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000473:pathology; D054990:Idiopathic Pulmonary Fibrosis / Q000473:pathology*; D008168:Lung / Q000098:blood supply* / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000473:pathology*; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D009389:Neovascularization, Pathologic; D011379:Prognosis; D011658:Pulmonary Fibrosis / Q000473:pathology*; D012333:RNA, Messenger / Q000235:genetics; D014057:Tomography, X-Ray Computed; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2