title: Fluorescent probes for monitoring regulated secretion.
abstract: Numerous secretory cells use the regulated secretory pathway to release signaling molecules. Regulated secretion is an essential component of the intercellular communication network of a multicellular organism and serves diverse functions in neurobiology, endocrinology, and many other aspects of animal physiology. Probes that can monitor a specific exocytotic event with high temporal and spatial resolution would be invaluable tools for studying the molecular and cellular mechanisms underlying stimulus-secretion coupling, and for characterizing secretion defects that are found in different human diseases. This review summarizes different strategies and recent progress in developing fluorescent sensors for imaging regulated cell secretion.
authors.affiliation: Department of Cell Biology and of Biochemistry, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390-9039, United States. Wen-hong.li@utsouthwestern.edu
authors.forename: Wen-hong
authors.initials: WH
authors.lastname: Li
authors.forename: Daliang
authors.initials: D
authors.lastname: Li
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis / Q000378:metabolism; D000596:Amino Acids / Q000032:analysis / Q000378:metabolism; D000818:Animals; D005089:Exocytosis; D005456:Fluorescent Dyes / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D015032:Zinc / Q000032:analysis / Q000378:metabolism
chemical_list: D000596:Amino Acids; D005456:Fluorescent Dyes; D000255:Adenosine Triphosphate; D015032:Zinc