title: Macular pseudohole development after sustained-release dexamethasone intravitreal implant for macular edema due to central retinal vein occlusion.
abstract: OBJECTIVE
  To report a case of macular pseudohole (MPH) development after sustained-release dexamethasone intravitreal implant for chronic macular edema due to central retinal vein occlusion (CRVO).
  
  
  METHODS
  A 70-year-old man with cystoid macular edema (CME) due to CRVO underwent sustained-release dexamethasone intravitreal implant. En face optical coherence tomography (OCT) was performed before and after treatment.
  
  
  RESULTS
  One month after dexamethasone intravitreal implant, best-corrected visual acuity (BCVA) improved from 1.0 to 0.5 logMAR. At 2 months, BCVA decreased from 0.5 to 1.3 logMAR. En face OCT detected the development of MPH due to exacerbation of centripetal vitreomacular transverse tractional forces on the overlying retina.
  
  
  CONCLUSIONS
  Macular pseudohole seems to be a complication of intravitreal therapy in patients with coexisting vitreomacular traction. En face OCT gives useful information to understand the mechanism of MPH development after sustained-release dexamethasone intravitreal implant.
authors.affiliation: Department of Medicine and Science of Ageing, Ophthalmology Clinic, University "G. d'Annunzio" Chieti-Pescara - Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Di Antonio
authors.forename: Lisa
authors.initials: L
authors.lastname: Toto
authors.forename: Paolo
authors.initials: P
authors.lastname: Carpineto
authors.forename: Alessandra
authors.initials: A
authors.lastname: Mastropasqua
authors.forename: Chiara
authors.initials: C
authors.lastname: De Nicola
authors.forename: Leonardo
authors.initials: L
authors.lastname: Mastropasqua
mesh_terms: D000368:Aged; D003907:Dexamethasone / Q000009:adverse effects*; D004343:Drug Implants; D019773:Epiretinal Membrane / Q000473:pathology; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008269:Macular Edema / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D012167:Retinal Perforations / Q000139:chemically induced* / Q000175:diagnosis; D012170:Retinal Vein Occlusion / Q000150:complications / Q000188:drug therapy*; D058471:Subretinal Fluid; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000139:chemically induced / Q000175:diagnosis; D014792:Visual Acuity / Q000502:physiology; D014822:Vitreous Body
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone