title: Inhibitory effect of coated mannan against the adhesion of Candida biofilms to denture base resin.
abstract: The adherence of Candida on dentures is related to diseases such as denture stomatitis and aspiration pneumonia. Mannan is a major component of the Candida cell surface, and contributes to the cell adherence. A previous report indicated that the adherence of C. albicans to culture dishes was inhibited by the coating them with mannan. The purpose of this study was to examine the adhesion inhibitory effect of mannan coating on acrylic denture surfaces against C. albicans and C. glabrata. The amount of Candida attached on the acrylic surfaces coated with mannan was calibrated by culture methods. Mannan showed significant inhibitory effects on Candida adhesion in both the yeast and hyphal form in a concentration-dependent manner, and the durability of the inhibitory effect continued for three days. These results suggest that mannan coating on the denture base acrylic can prevent Candida adhesion on the denture.
authors.affiliation: Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, Kanagawa 230- 8501, Japan. sato-maki@tsurumi-u.ac.jp
authors.forename: Maki
authors.initials: M
authors.lastname: Sato
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ohshima
authors.forename: Nobuko
authors.initials: N
authors.lastname: Maeda
authors.forename: Chikahiro
authors.initials: C
authors.lastname: Ohkubo
mesh_terms: D000180:Acrylic Resins; D018441:Biofilms / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects* / Q000502:physiology; D041221:Candida glabrata / Q000187:drug effects* / Q000502:physiology; D002448:Cell Adhesion / Q000187:drug effects*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D003819:Denture Bases / Q000382:microbiology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008351:Mannans / Q000494:pharmacology*; D018709:Statistics, Nonparametric; D013282:Stomatitis, Denture / Q000382:microbiology / Q000517:prevention & control; D013997:Time Factors
chemical_list: D000180:Acrylic Resins; D020099:Coated Materials, Biocompatible; D008351:Mannans