title: Accumulation of hydroxylated polychlorinated biphenyls (OH-PCBs) and implications for PCBs metabolic capacities in three porpoise species.
abstract: The present study investigated polychlorinated biphenyls (PCBs) and hydroxylated metabolites of PCBs (OH-PCBs) in blood from three porpoise species: finless porpoises (Neophocaena phocaenoides), harbor porpoises (Phocoena phocoena), and Dall's porpoises (Phocoenoides dalli). The porpoises were found stranded or were bycaught along the Japanese coast. Concentrations of OH-PCB were the highest in Dall's porpoises (58pgg(-1) wet wt), second highest in finless porpoises (20pgg(-1) wet wt), and lowest in harbor porpoises (8.3pgg(-1) wet wt). The concentrations in Dall's porpoises were significantly higher than the concentrations in finless porpoises and harbor porpoises (p<0.05 and p<0.01, respectively). There was a positive correlation between PCB and OH-PCB concentrations (r=0.67, p<0.001), suggesting the possible concentration-dependent induction of CYP enzymes. The three porpoise species may have exceptionally low metabolic capacities compared with other marine and terrestrial mammals, because low OH-PCB/PCB concentration ratios were found, which were 0.0016 for Dall's porpoises, 0.0013 for harbor porpoises, and 0.00058 for finless porpoises. Distinct differences in the OH-PCB congener patterns were observed for the three species, even though they are taxonomically closely related.
authors.affiliation: Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, Matsuyama 790-8577, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Ochiai
authors.forename: Kei
authors.initials: K
authors.lastname: Nomiyama
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Isobe
authors.forename: Hazuki
authors.initials: H
authors.lastname: Mizukawa
authors.forename: Tadasu K
authors.initials: TK
authors.lastname: Yamada
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tajima
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuishi
authors.forename: Masao
authors.initials: M
authors.lastname: Amano
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Tanabe
mesh_terms: D000818:Animals; D006900:Hydroxylation; D010140:Pacific Ocean; D050741:Phocoena / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D019576:Porpoises / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000493:pharmacokinetics*
chemical_list: D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls