title: The time-dependent hormetic effects of 1-alkyl-3-methylimidazolium chloride and their mixtures on Vibrio qinghaiensis sp. -Q67.
abstract: The hormetic effects of ionic liquids (ILs) were paid more ecological attentions. However, the time-dependent hormetic effects of ILs and their mixtures remained to be studied. In this paper, the time-dependent toxicities of five single ILs, 1-ethyl-, 1-butyl-, 1-hexyl-, 1-octyl-, and 1-dodecyl-3-methylimidazolium chlorides (named as [C2mim]Cl, [C4mim]Cl, [C6mim]Cl, [C8mim]Cl, and [C12mim]Cl, respectively), and their five-component mixtures to Vibrio qinghaiensis sp.-Q67 were determined at five exposure time points. For single ILs, [C2mim]Cl displayed significant hormetic effects at 2, 4, 8, and 12h; and [C4mim]Cl exhibited significant hormetic effects at 4, 8 and 12h; while [C6mim]Cl, [C8mim]Cl and [C12mim]Cl have not significant hormetic effects. At the same time point, the longer the side chain is, the larger the inhibition at high concentration is, and the less the stimulation at low concentration is. Meanwhile, the maximum stimulation effects were found between 4 and 8h. All six IL mixtures designed by uniform design ray showed significant hormetic effects at 8 and 12h. By means of the variable selection and modeling method based on the prediction (VSMP), it was found that the higher the concentration of [C2mim]Cl is, the stronger the mixture hormetic effect is and the higher the concentration of [C12mim]Cl is, the weaker the hormetic effect is.
authors.affiliation: Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Shu-Shen
authors.initials: SS
authors.lastname: Liu
authors.forename: Zhen-Yang
authors.initials: ZY
authors.lastname: Yu
authors.forename: Hai-Ling
authors.initials: HL
authors.lastname: Liu
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
mesh_terms: D059165:Hormesis; D007093:Imidazoles / Q000737:chemistry / Q000633:toxicity*; D052578:Ionic Liquids; D013997:Time Factors; D014733:Vibrio / Q000187:drug effects*
chemical_list: D007093:Imidazoles; D052578:Ionic Liquids