title: Heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats.
abstract: To evaluate the effect of the saponin of heat-processed ginseng (Sun ginseng, SG), we investigated the protective effect of SG total saponin fraction against adenine-induced chronic renal failure in rats. SG saponin significantly decreased the levels of urea nitrogen and creatinine in the serum, but increased the urinary excretion of urea nitrogen and creatinine, indicating an improvement of renal function. SG saponin also inhibited adenine-induced kidney hypertrophy and edema. SG saponin reduced serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and lactate dehydrogenase activities increased by adenine. Based on these findings, the ameliorating effect of SG on chronic renal failure may result from its saponin.
authors.affiliation: College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea.
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Kim
authors.forename: Hyun-A
authors.initials: HA
authors.lastname: Oh
authors.forename: Hyuck Jai
authors.initials: HJ
authors.lastname: Choi
authors.forename: Jeong Hill
authors.initials: JH
authors.lastname: Park
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Nam Jae
authors.initials: NJ
authors.lastname: Kim
keywords: Ginseng; Panax ginseng; Renal insufficiency; Saponin; Sun ginseng