title: Study of histopathological changes in primary atrophic rhinitis.
abstract: Primary atrophic rhinitis is a progressive chronic nasal disease and histopathologically characterized by squamous metaplasia and two characteristic types of vascular involvement (type I and type II). Despite its chronicity and squamous transformation, nothing is known about the occurrence of malignancy in atrophic rhinitis. The present work was undertaken to study the histopathological characteristics in primary atrophic rhinitis and identify whether it has any association with malignant transformation. Nasal biopsies obtained from 90 patients diagnosed as primary atrophic rhinitis were studied. Squamous metaplasia was noted in 89% of patients, and type I and type II vascular involvement were seen in 67% and 33% of patients, respectively. This preliminary report suggests that there is no association between atrophic rhinitis and precancerous lesions of nasal cavity despite squamous metaplasia and confirms the presence of two types of vascular changes in the disease which is helpful to decide the treatment modality.
authors.affiliation: Department of ENT & Pharmacology, Himalayan Institute of Medical Sciences, Dehradun 248140, India.
authors.forename: Sampan S
authors.initials: SS
authors.lastname: Bist
authors.forename: Manisha
authors.initials: M
authors.lastname: Bisht
authors.forename: Jagdish P
authors.initials: JP
authors.lastname: Purohit
authors.forename: Ratna
authors.initials: R
authors.lastname: Saxena