title: Dabigatran, ROCKET atrial fibrillation, and beyond: basic science, mechanisms of agents, monitoring, and reversal.
authors.affiliation: Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA. kbauer@bidmc.harvard.edu
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Bauer
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D000991:Antithrombins / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications / Q000517:prevention & control*; D001562:Benzimidazoles / Q000627:therapeutic use*; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000628:therapy; D000069604:Dabigatran; D065427:Factor Xa Inhibitors; D006801:Humans; D008991:Monitoring, Physiologic; D009025:Morpholines / Q000627:therapeutic use; D011355:Prodrugs; D011720:Pyrazoles / Q000627:therapeutic use; D011728:Pyridones / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D000069552:Rivaroxaban; D020521:Stroke / Q000209:etiology / Q000517:prevention & control; D013876:Thiophenes / Q000627:therapeutic use; D013917:Thrombin / Q000037:antagonists & inhibitors; D013923:Thromboembolism / Q000209:etiology / Q000517:prevention & control; D014812:Vitamin K / Q000037:antagonists & inhibitors; D014859:Warfarin / Q000627:therapeutic use; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D001562:Benzimidazoles; D001779:Blood Coagulation Factors; D065427:Factor Xa Inhibitors; D009025:Morpholines; D011355:Prodrugs; D011720:Pyrazoles; D011728:Pyridones; D013876:Thiophenes; D015091:beta-Alanine; D014812:Vitamin K; C522181:apixaban; D014859:Warfarin; D000069552:Rivaroxaban; D013917:Thrombin; D000069604:Dabigatran
keywords: apixaban; atrial fibrillation; dabigatran; international normalized ratio; prothrombin time; rivaroxaban; vitamin K antagonists