title: Association of a single nucleotide polymorphism in the akirin 2 gene with economically important traits in Korean native cattle.
abstract: The akirin 2 gene, located on chromosome 9 in cattle, was previously reported to be associated with nuclear factor-kappa B (NF-κB), involved in immune reactions and marbling of meat. To determine whether a single nucleotide polymorphism (SNP) in akirin 2 is associated with economically important traits of Korean native cattle, the c.*188G>A SNP DNA marker in the 3'-UTR region of akirin 2 was analyzed for its association with carcass weight, longissimus muscle area and marbling. The c.*188G>A SNP was genotyped by polymerase chain reaction restriction fragment length polymorphism, and the frequency of the AA, AG, and GG genotypes were 6.82%, 71.29% and 21.88% respectively. This SNP was significantly associated with longissimus muscle area (Bonferroni corrected P < 0.05), and marbling score (Bonferroni corrected P < 0.01). These results suggest that the c.*188G>A SNP of akirin 2 might be useful as a DNA marker for longissimus muscle area and marbling scores in Korean native cattle.
authors.affiliation: College of Animal Life Sciences, Kangwon National University, Chuncheon, 200-701, Korea.
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.forename: S K
authors.initials: SK
authors.lastname: Lee
authors.forename: M W
authors.initials: MW
authors.lastname: Hong
authors.forename: S R
authors.initials: SR
authors.lastname: Park
authors.forename: Y S
authors.initials: YS
authors.lastname: Lee
authors.forename: J W
authors.initials: JW
authors.lastname: Kim
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
authors.forename: D K
authors.initials: DK
authors.lastname: Jeong
authors.forename: Y H
authors.initials: YH
authors.lastname: Song
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000818:Animals; D001483:Base Sequence; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D017931:DNA Primers / Q000235:genetics; D020224:Expressed Sequence Tags; D005787:Gene Frequency; D005838:Genotype; D016014:Linear Models; D008055:Lipids / Q000032:analysis / Q000235:genetics; D008460:Meat / Q000032:analysis*; D008969:Molecular Sequence Data; D018482:Muscle, Skeletal / Q000737:chemistry; D016328:NF-kappa B / Q000235:genetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D056910:Republic of Korea; D017422:Sequence Analysis, DNA / Q000662:veterinary
chemical_list: D017931:DNA Primers; D008055:Lipids; D016328:NF-kappa B; D012097:Repressor Proteins
keywords: AKIRIN2 gene; longissimus muscle area; marbling score; single nucleotide polymorphism