title: A composite risk model for predicting technical failure in pancreas transplantation.
abstract: Technical failure (TF) continues to have a significant impact on the success of pancreas transplantation. We assessed risk factors for TF in 1115 pancreas transplants performed at a single center between 1998 and 2011. The overall TF rate was 10.2%. In a multivariable model, donor BMI ≥ 30 (HR 1.87, p = 0.005), donor Cr ≥ 2.5 (HR 3.16, p = 0.007), donor age >50 (HR 1.73, p = 0.082) and preservation time >20 h (HR 2.17, p < 0.001) were associated with TF. Bladder drainage of exocrine secretions was protective (HR 0.54, p = 0.002). We incorporated these factors in a Composite Risk Model. In this model the presence of one risk factor did not significantly increase risk of TF (HR 1.35, p = 0.346). Two risk factors in combination increased risk greater than threefold (HR 3.65, p < 0.001) and three risk factors increased risk greater than sevenfold (HR 7.66, p = <0.001). The analysis also identified many factors that were not predictive of TF, including previous transplants, immunosuppressive agent selection, and almost all recipient demographic parameters. While the model suggests that two or more risk factors predict TF, strategies to reduce preservation time may mitigate some of this risk.
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis, MN, USA. efinger@umn.edu
authors.forename: E B
authors.initials: EB
authors.lastname: Finger
authors.forename: D M
authors.initials: DM
authors.lastname: Radosevich
authors.forename: T B
authors.initials: TB
authors.lastname: Dunn
authors.forename: S
authors.initials: S
authors.lastname: Chinnakotla
authors.forename: D E R
authors.initials: DE
authors.lastname: Sutherland
authors.forename: A J
authors.initials: AJ
authors.lastname: Matas
authors.forename: T L
authors.initials: TL
authors.lastname: Pruett
authors.forename: R
authors.initials: R
authors.lastname: Kandaswamy
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D009927:Tissue and Organ Procurement / Q000592:standards; D017211:Treatment Failure; D014481:United States / Q000453:epidemiology