title: Alternatives to antibiotics: a symposium on the challenges and solutions for animal production.
abstract: Antibiotics are one of the most important medical discoveries of the 20th century and will remain an essential tool for treating animal and human diseases in the 21st century. However, antibiotic resistance among bacterial pathogens and concerns over their extensive use in food animals has garnered global interest in limiting antibiotic use in animal agriculture. Yet, limiting the availability of medical interventions to prevent and control animal diseases on the farm will directly impact global food security and safety as well as animal and human health. Insufficient attention has been given to the scientific breakthroughs and novel technologies that provide alternatives to antibiotics. The objectives of the symposium 'Alternatives to Antibiotics' were to highlight promising research results and novel technologies that could potentially lead to alternatives to conventional antibiotics, and assess challenges associated with their commercialization, and provide actionable strategies to support development of alternative antimicrobials. The symposium focused on the latest scientific breakthroughs and technologies that could provide new options and alternative strategies for preventing and treating diseases of animals. Some of these new technologies have direct applications as medical interventions for human health, but the focus of the symposium was animal production, animal health and food safety during food-animal production. Five subject areas were explored in detail through scientific presentations and expert panel discussions, including: (1) alternatives to antibiotics, lessons from nature; (2) immune modulation approaches to enhance disease resistance and to treat animal diseases; (3) gut microbiome and immune development, health and diseases; (4) alternatives to antibiotics for animal production; and (5) regulatory pathways to enable the licensure of alternatives to antibiotics.
authors.affiliation: Poultry Microbiological Safety Research Unit, R.B. Russell Agricultural Research Center, Agricultural Research Service, USDA, 950 College Station Road, Athens, GA 30605, USA. bruce.seal@ars.usda.gov
authors.forename: Bruce S
authors.initials: BS
authors.lastname: Seal
authors.forename: Hyun S
authors.initials: HS
authors.lastname: Lillehoj
authors.forename: David M
authors.initials: DM
authors.lastname: Donovan
authors.forename: Cyril G
authors.initials: CG
authors.lastname: Gay
mesh_terms: D000821:Animal Feed; D000822:Animal Husbandry / Q000379:methods*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D001419:Bacteria / Q000187:drug effects*; D000075202:Contraindications; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006133:Growth Substances / Q000008:administration & dosage*; D006801:Humans; D008460:Meat
chemical_list: D000900:Anti-Bacterial Agents; D006133:Growth Substances