title: Faecal calprotectin concentrations in gastrointestinal diseases.
abstract: OBJECTIVE
  To quantify faecal calprotectin concentrations in a variety of gastrointestinal disorders in order to determine its diagnostic value.
  
  
  METHODS
  Patients with gastrointestinal symptoms undergoing upper or lower endoscopy and healthy control subjects provided stool samples. Calprotectin was quantified by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The study recruited 210 patients with definitively diagnosed gastrointestinal diseases and 50 control subjects. Calprotectin concentrations were significantly higher in patients with ulcerative colitis or Crohn's disease compared with controls, or patients with colorectal polyps or irritable bowel syndrome. The faecal calprotectin concentration significantly differentiated between inflammatory bowel diseases (IBD) and non-IBD (area under ROC curve 0.949). Calprotectin concentrations were significantly higher in patients with oesophageal polyps or gastric neoplasms than in those with chronic gastritis, stomach ulcers, duodenal ulcers or acute pancreatitis.
  
  
  CONCLUSIONS
  Calprotectin may be a useful noninvasive marker for the diagnosis of IBD.
authors.affiliation: Department of Gastroenterology, Jingling Hospital, Nanjing, China.
authors.forename: Shaodong
authors.initials: S
authors.lastname: Wang
authors.forename: Zhenkai
authors.initials: Z
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Shi
authors.forename: Lu
authors.initials: L
authors.lastname: Heng
authors.forename: Wei
authors.initials: W
authors.lastname: Juan
authors.forename: Boshi
authors.initials: B
authors.lastname: Yuan
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Wu
authors.forename: Fangyu
authors.initials: F
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000378:metabolism; D003111:Colonic Polyps / Q000175:diagnosis* / Q000378:metabolism; D003424:Crohn Disease / Q000175:diagnosis* / Q000378:metabolism; D004941:Esophagitis / Q000175:diagnosis* / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D005260:Female; D005756:Gastritis / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000175:diagnosis* / Q000378:metabolism; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex
keywords: Calprotectin; gastric inflammation; inflammatory bowel disease; oesophageal inflammation; screening