title: Ugi four-component reaction of alcohols: stoichiometric and catalytic oxidation/MCR sequences.
abstract: A new, simple, and efficient procedure for the one-pot Ugi four-component reaction of alcohols instead of aldehydes is described. Using a stoichiometric amount of IBX or only 1-2% of sodium 2-iodobenzenesulfonate in the presence of Oxone, a wide range of primary alcohols were oxidized to the aldehyde that were directly engaged in the Ugi four-component reaction to afford α-acetamidoamides in good to excellent yields.
authors.affiliation: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, ICSN, CNRS, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Fleur
authors.initials: F
authors.lastname: Drouet
authors.forename: Géraldine
authors.initials: G
authors.lastname: Masson
authors.forename: Jieping
authors.initials: J
authors.lastname: Zhu