title: Tardive dyskinesia from atypical antipsychotic agents in patients with mood disorders in a clinical setting.
abstract: BACKGROUND
  There is a paucity of information on the risks and clinical characteristics of tardive dyskinesia with atypical antipsychotic agents in patients with mood and anxiety disorders in clinical practice.
  
  
  METHODS
  The authors retrospectively screened the charts of 268 patients with a mood or anxiety disorder treated with atypical antipsychotic agents from a psychiatric practice. Fifteen patients who developed tardive dyskinesia were identified and further data was collected on these patients.
  
  
  RESULTS
  Tardive dyskinesia occurred in 5.9% of patients after exposure to an atypical antipsychotic agent for a mean of 28.7 months (range: 1-83). The average dosage of the offending agent in chlorpromazine equivalents was 350 mg/day (range: 67-969). All patients experienced oral-buccal-lingual stereotypy, which was frequently severe in nature, but completely resolved in all but one patient. Most patients (90.9%) who consented to a second trial of an atypical antipsychotic did not experience a relapse of TD.
  
  
  CONCLUSIONS
  All patients were treated in a clinical practice setting by a single psychiatrist, which may limit the generalizability of the findings.
  
  
  CONCLUSIONS
  The observed rate of TD represents a real world estimate of the risk of TD with atypical antipsychotic agents in patients with mood disorders. Fortunately, with early recognition symptoms appear to be reversible and further treatment with another atypical antipsychotic does not necessarily lead to relapse.
authors.affiliation: SUNY-Downstate Medical Center, Division of Neuropsychopharmacology, 450 Clarkson Ave, Box #120, Brooklyn, NY 11203, USA. copstat00@aol.com
authors.forename: Jeremy
authors.initials: J
authors.lastname: Coplan
authors.forename: James J
authors.initials: JJ
authors.lastname: Gugger
authors.forename: Hina
authors.initials: H
authors.lastname: Tasleem
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001008:Anxiety Disorders / Q000188:drug therapy; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000188:drug therapy*; D009069:Movement Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D012189:Retrospective Studies; D012306:Risk; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents
keywords: ADHD; AIMS; Abnormal Involuntary Movement Scale; Anxiety disorders; Attention-deficit hyperactivity disorder; Atypical antipsychotic agents; Extrapyramidal syndrome; GAD; Generalized anxiety disorder; MDD; MPH; MS; Major depressive disorder; Methylphenidate; Mood disorders; Multiple sclerosis; OCD; Obsessive-compulsive disorder; PTSD; Post-traumatic stress disorder; TRD; Tardive dyskinesia; Treatment-resistant depression