title: Meropenem resistance in imipenem-susceptible meropenem-resistant Klebsiella pneumoniae isolates not detected by rapid automated testing systems.
abstract: Klebsiella pneumoniae showing high resistance to all β-lactams except imipenem, designated as ISMRK (imipenem-susceptible meropenem-resistant Klebsiella) is emerging in Japan. The carbapenem resistance of ISMRK cannot be screened by the Vitek and the RAISUS rapid automated susceptibility test systems, which may lead to inappropriate antimicrobial therapy, resulting in compromised patient outcomes.
authors.affiliation: Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Minami-ku, Hiroshima City, Hiroshima, Japan.
authors.forename: Toshie
authors.initials: T
authors.lastname: Harino
authors.forename: Shizuo
authors.initials: S
authors.lastname: Kayama
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kuwahara
authors.forename: Seiya
authors.initials: S
authors.lastname: Kashiyama
authors.forename: Norifumi
authors.initials: N
authors.lastname: Shigemoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Onodera
authors.forename: Michiya
authors.initials: M
authors.lastname: Yokozaki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ohge
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Sugai
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003951:Diagnostic Errors; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D007564:Japan; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D000077731:Meropenem; D008826:Microbial Sensitivity Tests / Q000379:methods; D013845:Thienamycins / Q000494:pharmacology*; D018440:beta-Lactam Resistance
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015378:Imipenem; D000077731:Meropenem