title: Chemoresistance is associated with MUC1 and Lewis y antigen expression in ovarian epithelial cancers.
abstract: OBJECTIVE
  The aim of this study was to analyze the correlation and clinical significance between the expression of Mucin-1 (MUC1) and the Lewis y antigen with chemoresistance in ovarian epithelial cancers.
  
  
  METHODS
  Ovarian cancer patients (n = 92) treated at our hospital from May 2005 to July 2009 were divided, according to their treatment and follow-up outcomes, into a resistant group (n = 37) or sensitive group (n = 55). The expression of MUC1 and Lewis y antigen in ovarian cancer tissues was detected using immunohistochemistry and correlated with chemoresistance.
  
  
  RESULTS
  The positive rates of MUC1 and Lewis y antigen in the resistant group were both 91.89%, significantly higher than their positive rates in the sensitive group (65.45% and 69.09%, respectively, and both p < 0.05). MUC1 or Lewis y expression and the pathological stage of the tissue were independent risk factors for chemoresistance (all p < 0.05).
  
  
  CONCLUSIONS
  The increased expression of MUC1 and the Lewis y antigen is a significant risk factor for chemoresistance in patients with ovarian epithelial cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China. linbei88@hotmail.com.
authors.forename: Danye
authors.initials: D
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Gao
authors.forename: Liancheng
authors.initials: L
authors.lastname: Zhu
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Hu
authors.forename: Rui
authors.initials: R
authors.lastname: Hou
authors.forename: Shuice
authors.initials: S
authors.lastname: Liu
authors.forename: Mingzi
authors.initials: M
authors.lastname: Tan
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Liu
authors.forename: Bei
authors.initials: B
authors.lastname: Lin
mesh_terms: D000077216:Carcinoma, Ovarian Epithelial; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007983:Lewis Blood Group Antigens / Q000378:metabolism*; D018396:Mucin-1 / Q000378:metabolism*; D015999:Multivariate Analysis; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism* / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors
chemical_list: D007983:Lewis Blood Group Antigens; C094162:Lewis Y antigen; D018396:Mucin-1