title: Mollolide A, a diterpenoid with a new 1,10:2,3-disecograyanane skeleton from the roots of Rhododendron molle.
abstract: Mollolide A (1), a diterpenoid featuring a new 1,10:2,3-disecograyanane skeleton, was isolated from the roots of Rhododendron molle. Its structure was elucidated through extensive MS, IR, and NMR spectroscopy analyses. The absolute configuration was determined by single-crystal X-ray diffraction of its p-bromobenzoate derivative (1b). Compound 1 exhibits a significant analgesic effect at a dose of 20 mg/kg and antiviral activity against the Coxsackie B3 virus with an IC50 value of 27.7 μM.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, China, and Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Yun-Bao
authors.initials: YB
authors.lastname: Liu
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Yu-Huan
authors.initials: YH
authors.lastname: Li
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Jiang
authors.forename: Shi-Shan
authors.initials: SS
authors.lastname: Yu
authors.forename: Shuang-Gang
authors.initials: SG
authors.lastname: Ma
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
authors.forename: Hai-Ning
authors.initials: HN
authors.lastname: Lv
mesh_terms: D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry*; D029793:Rhododendron / Q000737:chemistry*
chemical_list: C550224:3,4-secograyanane; D004224:Diterpenes; C000588622:mollolide A