title: [Study on absorption location of four components from Naoxintong capsule].
abstract: OBJECTIVE
  To study the absorption characteristics of four components from Naoxintong capsule in intestines.
  
  
  METHODS
  In vitro everted gut sac method was adopted for preparing the intestinal absorption solution of Naoxintong capsule. UPLC was used to detect the content of chemical components in different intestinal segments, and comparing the results with the absorption of chemical components of Naoxintong capsule in each intestinal segment. The time-accumulative absorption curve was drawn to observe the changes in the accumulative absorption concentration with time.
  
  
  RESULTS
  Four ingredients of Naoxintong capsule can be detected in intestinal absorption solution, they are ferulic acid, paeoniflorin, salvianolic acid B and hydroxysafflor yellow A. Specifically, the accumulative absorption concentrations of ferulic acid, salvianolic acid B and paeoniflorin in ileum and rear jejunum segments were higher than that in front and middle jejunum segments; the absorption of ferulic acid, paeoniflorin, salvianolic acid B and hydroxysafflor yellow A did not reach saturated conditions in 3 hours.
  
  
  CONCLUSIONS
  Ferulic acid, paeoniflorin, salvianolic acid B and hydroxysafflor yellow A are absorbed in the whole intestine. Ferulic acid, paeoniflorin and salvianolic acid B may be absorbed in specific segments.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 100700, China. lsh-huangbin@qq.com
authors.forename: Bin
authors.initials: B
authors.lastname: Huang
authors.forename: Geng
authors.initials: G
authors.lastname: Li
authors.forename: Yu-Fei
authors.initials: YF
authors.lastname: Guo
authors.forename: Song-Song
authors.initials: SS
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Hai-Yu
authors.initials: HY
authors.lastname: Xu
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Yang
mesh_terms: D000818:Animals; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000378:metabolism*; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; C571443:naoxintong