title: The Drosophila ortholog of breast cancer metastasis suppressor gene, dBrms1, is critical for developmental timing through regulating ecdysone signaling.
abstract: BRMS1 was first discovered as a human breast carcinoma metastasis suppressor gene. However, the mechanism of BRMS1 in tumor metastasis and its developmental role remain unclear. In this paper, we first report the identification of the Drosophila ortholog of human BRMS1, dBrms1. Through a genetic approach, the role of dBrms1 during development has been investigated. We found that dBrms1 is an essential gene and loss of dBrms1 function results in lethality at early developmental stages. dBrms1mutants displayed phenotypes such as developmental delay and failure to initiate metamorphosis. Further analysis suggests that these phenotypes are contributed by defective ecdysone signaling and expression of target genes of the ecdysone pathway. Therefore, dBrms1 is required for growth control by acting as a modulator of ecdysone signaling in Drosophila and is required for metamorphosis for normal development.
authors.affiliation: School of Life Sciences, Peking University, Beijing, China.
authors.forename: Shilin
authors.initials: S
authors.lastname: Song
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yuan
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Lu
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.forename: Zuoyan
authors.initials: Z
authors.lastname: Zhu
authors.forename: Qichang
authors.initials: Q
authors.lastname: Fan
authors.forename: Youfang
authors.initials: Y
authors.lastname: Xue
authors.forename: Zhi-Chun
authors.initials: ZC
authors.lastname: Lai
authors.forename: Wenxia
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004330:Drosophila; D004440:Ecdysone / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D016147:Genes, Tumor Suppressor; D008675:Metamorphosis, Biological; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics*; D012097:Repressor Proteins; D015398:Signal Transduction; D013997:Time Factors; D019076:Transgenes
chemical_list: C410024:BRMS1 protein, human; D009363:Neoplasm Proteins; D012097:Repressor Proteins; D004440:Ecdysone
keywords: Breast cancer metastasis suppressor 1; Brms1; Developmental timing; Drosophila; Ecdysone signaling