title: A cross-sectional study of the relationship between serum sexual hormone levels and internal derangement of temporomandibular joint.
abstract: Temporomandibular disorders (TMD) are defined as clinical conditions that involve the masticatory muscles, temporomandibular joint (TMJ) or both. The aim of this study was to evaluate serum 17β-oestradiol and progesterone levels in menstruating women affected by internal derangement of the TMJ. A total of 142 women (mean age 30·2 ± 6·7) who referred to medical diagnostic laboratory of Iranian Academic Centre for Education, Culture and Research (ACECR), Mashhad Branch, were enrolled during 2007 and 2008. Forty-seven individuals had disc displacement with reduction (Group IIa) according to Research Diagnostic Criteria (RDC)/TMD Axis I diagnosis. Radioimmunoassay was used for the detection of serum 17β-oestradiol and progesterone levels in all 142 subjects. The mean progesterone level was significantly higher in control group (11·6 ± 10·4 ng mL(-1) ) compared to women with TMD (8·4 ± 6·8 ng mL(-1) , P = 0·03). No significant difference was found in two groups regarding 17β-oestradiol level. Lower progesterone level in women with TMD can suggest the more important role of this hormone in the development of the disorder.
authors.affiliation: Oral & Maxillofacial Diseases Research Center, Department of Prosthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: A S
authors.initials: AS
authors.lastname: Madani
authors.forename: A A
authors.initials: AA
authors.lastname: Shamsian
authors.forename: M R
authors.initials: MR
authors.lastname: Hedayati-Moghaddam
authors.forename: F
authors.initials: F
authors.lastname: Fathi-Moghadam
authors.forename: M R
authors.initials: MR
authors.lastname: Sabooni
authors.forename: A
authors.initials: A
authors.lastname: Mirmortazavi
authors.forename: M
authors.initials: M
authors.lastname: Golmohamadi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D004204:Joint Dislocations / Q000097:blood / Q000503:physiopathology; D011374:Progesterone / Q000097:blood*; D011863:Radioimmunoassay; D013704:Temporomandibular Joint / Q000503:physiopathology; D019224:Temporomandibular Joint Disc / Q000503:physiopathology; D013706:Temporomandibular Joint Dysfunction Syndrome / Q000097:blood* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D011374:Progesterone; D004958:Estradiol
keywords: internal derangement; oestradiol; progesterone; temporo-mandibular joint