title: Associations between lifestyles and neutrophil-lymphocyte and platelet-lymphocyte ratios in colorectal cancer.
abstract: OBJECTIVE
  To explore the etiology of the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) abnormalities in colorectal cancer.
  
  
  METHODS
  In total, 230 patients with histopathologically confirmed colorectal cancer from August 2009 to August 2011 were recruited to our study. The associations between lifestyles (smoking, alcohol and pickled food consumption) and pretreatment NLR and PLR were estimated using the Kruskal-Wallis tests and linear regression model.
  
  
  RESULTS
  The Kruskal-Wallis test showed a significant association between pickled food intake and pretreatment NLR but not PLR (P = 0.002, 0.057, respectively). Pairwise comparisons showed that, compared with those with a moderately frequent (2-3 times/week) and an infrequent (≤ once a week) intake of pickled food, high frequency (≥ four times/week) consumption of pickled food had a higher pretreatment NLR (P = 0.01, 0.007, respectively). Multivariate linear regression analysis showed pretreatment NLR increased significantly in high frequency (≥ four times/week) consumption of pickled food (P < 0.0001). No association between other lifestyle factors and pretreatment PLR was found.
  
  
  CONCLUSIONS
  A higher frequency intake of pickled food possibly contributes to higher NLR, which may reflect a systemic inflammatory response in colorectal cancer.
authors.affiliation: Department of Gastrointestinal Surgery, Lab of Surgery.
authors.forename: Chuyuan
authors.initials: C
authors.lastname: Hong
authors.forename: Yisheng
authors.initials: Y
authors.lastname: Wei
authors.forename: Jianxin
authors.initials: J
authors.lastname: Jiang
authors.forename: Chuxiong
authors.initials: C
authors.lastname: Zhao
authors.forename: Guojian
authors.initials: G
authors.lastname: Liang
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
mesh_terms: D001792:Blood Platelets / Q000473:pathology*; D002681:China; D015179:Colorectal Neoplasms / Q000097:blood* / Q000209:etiology*; D005260:Female; D006801:Humans; D008019:Life Style; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000473:pathology*; D011379:Prognosis
keywords: colorectal cancer; etiology; multivariate analysis; neutrophil to lymphocyte ratio; platelet to lymphocyte ratio