title: Specificity of paediatric jawbone lesions: tumours and pseudotumours.
abstract: BACKGROUND
  Characteristics and epidemiology of jaw tumours have been described mostly in adults. Compared with their adult counterparts, childhood jaw tumours show considerable differences. The aim of this study was to describe the different jaw tumours in children, define diagnostic tools to determine their specificity and describe optimal treatment.
  
  
  METHODS
  All children patients with jaw lesions, excluding cysts, apical granuloma and osteitis were included in our study between 1999 and 2009. The medical records were analyzed for clinical, radiological, and pathological findings, treatments and recurrences.
  
  
  RESULTS
  Mean patient age was 10.9 years old, ranging from 2 months to 18 years old. Of the 63 lesions, 18 were odontogenic and 45 non-odontogenic lesions. 6% of all cases were malignant tumours; the mean age of presentation was 7.25 years old, [ranging from 0.2 to 18 years old]. Approximately 80% of the tumours developed after 6 years of age. Odontogenic tumours occurred more often after the age of 6.
  
  
  CONCLUSIONS
  Compared with their adult counterpart, childhood jaw tumours show considerable differences in their clinical behaviour and radiological and pathological characteristics. Clinical features of some tumours can be specific to children. Tumourigenesis is related to dental development and facial growth. Conservative treatment should be considered.
authors.affiliation: APHP, Hôpital Necker Enfant Malades (Head of the Department: Vazquez), Service de chirurgie maxillo-faciale, Paris F75015, France; Université Paris 5, UFR médecine Paris Descartes, Paris F75006, France; Centre de références des malformations de la face et de la cavité buccale (Head of the Department: Vazquez), France; Laboratoire de Physiopathologie orale et Moléculaire (Head of the Department: Berdal), INSERM, UMRS 872, Equipe 5, Centre de recherche des Cordeliers, Paris 75006, France. Electronic address: natacha.kadlub@gmail.com.
authors.forename: Natacha
authors.initials: N
authors.lastname: Kadlub
authors.affiliation: APHP, Hôpital Armand Trousseau (Head of the Department: Ducou Lepointe), Service d'Imagerie Médicale, Paris F75012, France; Université Pierre et Marie Curie 6, UFR médecine Pierre et Marie Curie, Paris F75005, France.
authors.forename: Tamara
authors.initials: T
authors.lastname: Kreindel
authors.affiliation: Université Pierre et Marie Curie 6, UFR médecine Pierre et Marie Curie, Paris F75005, France; APHP, Hôpital Armand Trousseau (Head of the Department: Coulomb L'Hermine), Service de cytologie et anatomopathologie, Paris F75012, France.
authors.forename: Valère
authors.initials: V
authors.lastname: Belle Mbou
authors.affiliation: Laboratoire de Physiopathologie orale et Moléculaire (Head of the Department: Berdal), INSERM, UMRS 872, Equipe 5, Centre de recherche des Cordeliers, Paris 75006, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Coudert
authors.affiliation: APHP, Hôpital Necker Enfant Malades (Head of the Department: Vazquez), Service de chirurgie maxillo-faciale, Paris F75015, France; Université Paris 5, UFR médecine Paris Descartes, Paris F75006, France; Centre de références des malformations de la face et de la cavité buccale (Head of the Department: Vazquez), France; Laboratoire de Physiopathologie orale et Moléculaire (Head of the Department: Berdal), INSERM, UMRS 872, Equipe 5, Centre de recherche des Cordeliers, Paris 75006, France.
authors.forename: Edward
authors.initials: E
authors.lastname: Ansari
authors.affiliation: Laboratoire de Physiopathologie orale et Moléculaire (Head of the Department: Berdal), INSERM, UMRS 872, Equipe 5, Centre de recherche des Cordeliers, Paris 75006, France; APHP, Hôpital Pitie Salpetrière (Head of the Department: Azerad), Service d'odontologie, Paris F75013, France.
authors.forename: Vianney
authors.initials: V
authors.lastname: Descroix
authors.affiliation: Laboratoire de Physiopathologie orale et Moléculaire (Head of the Department: Berdal), INSERM, UMRS 872, Equipe 5, Centre de recherche des Cordeliers, Paris 75006, France; Université Pierre et Marie Curie 6, UFR médecine Pierre et Marie Curie, Paris F75005, France; APHP, Hôpital Pitie Salpetrière (Head of the Department: Goudot), Service de chirurgie maxillo-faciale, Paris F75013, France.
authors.forename: Blandine
authors.initials: B
authors.lastname: Ruhin-Poncet
authors.affiliation: Université Pierre et Marie Curie 6, UFR médecine Pierre et Marie Curie, Paris F75005, France; APHP, Hôpital Armand Trousseau (Head of the Department: Coulomb L'Hermine), Service de cytologie et anatomopathologie, Paris F75012, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Coulomb L'hermine
authors.affiliation: Centre de références des malformations de la face et de la cavité buccale (Head of the Department: Vazquez), France; Laboratoire de Physiopathologie orale et Moléculaire (Head of the Department: Berdal), INSERM, UMRS 872, Equipe 5, Centre de recherche des Cordeliers, Paris 75006, France.
authors.forename: Ariane
authors.initials: A
authors.lastname: Berdal
authors.affiliation: APHP, Hôpital Necker Enfant Malades (Head of the Department: Vazquez), Service de chirurgie maxillo-faciale, Paris F75015, France; Université Paris 5, UFR médecine Paris Descartes, Paris F75006, France; Centre de références des malformations de la face et de la cavité buccale (Head of the Department: Vazquez), France; Laboratoire de Physiopathologie orale et Moléculaire (Head of the Department: Berdal), INSERM, UMRS 872, Equipe 5, Centre de recherche des Cordeliers, Paris 75006, France.
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Vazquez
authors.affiliation: APHP, Hôpital Armand Trousseau (Head of the Department: Ducou Lepointe), Service d'Imagerie Médicale, Paris F75012, France; Université Pierre et Marie Curie 6, UFR médecine Pierre et Marie Curie, Paris F75005, France.
authors.forename: Hubert
authors.initials: H
authors.lastname: Ducou Lepointe
authors.affiliation: APHP, Hôpital Necker Enfant Malades (Head of the Department: Vazquez), Service de chirurgie maxillo-faciale, Paris F75015, France; Université Paris 5, UFR médecine Paris Descartes, Paris F75006, France; Centre de références des malformations de la face et de la cavité buccale (Head of the Department: Vazquez), France; Laboratoire de Physiopathologie orale et Moléculaire (Head of the Department: Berdal), INSERM, UMRS 872, Equipe 5, Centre de recherche des Cordeliers, Paris 75006, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Picard
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000564:Ameloblastoma / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004803:Eosinophilic Granuloma / Q000175:diagnosis; D005260:Female; D018214:Fibroma, Ossifying / Q000175:diagnosis; D018222:Desmoid Tumors / Q000175:diagnosis; D005357:Fibrous Dysplasia of Bone / Q000175:diagnosis; D006101:Granuloma, Giant Cell / Q000175:diagnosis; D006391:Hemangioma / Q000175:diagnosis; D006801:Humans; D007223:Infant; D007570:Jaw Cysts / Q000175:diagnosis; D007571:Jaw Diseases / Q000175:diagnosis; D007573:Jaw Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D047708:Myofibroma / Q000175:diagnosis; D017600:Neuroectodermal Tumor, Melanotic / Q000175:diagnosis; D009808:Odontogenic Tumors / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D009810:Odontoma / Q000175:diagnosis; D012189:Retrospective Studies; D012509:Sarcoma / Q000175:diagnosis; D014057:Tomography, X-Ray Computed / Q000379:methods
keywords: Children tumour; Facial tumour; Jaw tumour; Mandible tumour; Maxilla tumour