title: Prognostic value of serum cholinesterase activities in sepsis patients.
abstract: OBJECTIVE
  This study aims to explore the prognostic value of Serum cholinesterase (SchE) activity in patients with sepsis.
  
  
  METHODS
  The evaluation variable of APACHE II score was assessed and the SchE concentrations were determined in 359 patients immediately upon admission and 24 hours after admission. All patients were divided into two groups based on their prognosis. The relationships of SchE concentration and APACHE II score with prognosis were analyzed.
  
  
  RESULTS
  The SchE activity was significantly higher (p <0.01) and the APACHE II score was significantly lower (p <0.01) in survivors than in non-survivors. The areas under the receiver operating characteristic curve (AUC) were more than 0.9 for both the loss of SchE activity (delta SchE) and the loss of APACHE II score (delta APACHE II) during 24 h in patients admitted 24 h after onset (D1). The AUC for SchE activity and APACHE II were similar in most groups except hepatobiliary infection group.
  
  
  CONCLUSIONS
  The SchE activity and APACHE II score were useful for prognosis of septic patients. Although SchE activity was not as powerful as APACHE II in the prognosis of sepsis, dynamic monitoring of SchE and APACHE II had similar value in outcome prediction.
authors.forename: Wenming
authors.initials: W
authors.lastname: Feng
authors.forename: Chengwu
authors.initials: C
authors.lastname: Tang
authors.forename: Huihui
authors.initials: H
authors.lastname: Guo
authors.forename: Ying
authors.initials: Y
authors.lastname: Bao
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wen
authors.forename: Tao
authors.initials: T
authors.lastname: Xue
authors.forename: Hui
authors.initials: H
authors.lastname: Gong
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D002802:Cholinesterases / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018805:Sepsis / Q000201:enzymology / Q000401:mortality*
chemical_list: D002802:Cholinesterases