title: Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis.
abstract: OBJECTIVE
  To estimate age-specific probabilities of live birth with oocyte cryopreservation in nondonor (ND) egg cycles.
  
  
  METHODS
  Individual patient data meta-analysis.
  
  
  METHODS
  Assisted reproduction centers.
  
  
  METHODS
  Infertile patients undergoing ND mature oocyte cryopreservation.
  
  
  METHODS
  PubMed was searched for clinical studies on oocyte cryopreservation from January 1996 through July 2011. Randomized and nonrandomized studies that used ND frozen-thawed mature oocytes with pregnancy outcomes were included. Authors of eligible studies were contacted to obtain individual patient data.
  
  
  METHODS
  Live birth probabilities based on age, cryopreservation method, and the number of oocytes thawed, injected, or embryos transferred.
  
  
  RESULTS
  Original data from 10 studies including 2,265 cycles from 1,805 patients were obtained. Live birth success rates declined with age regardless of the freezing technique. Despite this age-induced compromise, live births continued to occur as late as ages 42 and 44 years with slowly frozen and vitrified oocytes, respectively. Estimated probabilities of live birth for vitrified oocytes were higher than those for slowly frozen.
  
  
  CONCLUSIONS
  The live birth probabilities we calculated would enable more accurate counseling and informed decisions for infertile women considering oocyte cryopreservation. Given the success probabilities, we suggest that policy makers should consider oocyte freezing as an integral part of prevention and treatment of infertility.
authors.affiliation: Innovation Institute for Fertility Preservation and IVF, New York, NY 10028, USA.
authors.forename: Aylin Pelin
authors.initials: AP
authors.lastname: Cil
authors.forename: Heejung
authors.initials: H
authors.lastname: Bang
authors.forename: Kutluk
authors.initials: K
authors.lastname: Oktay
mesh_terms: D000328:Adult; D000367:Age Factors; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007206:Individuality; D007231:Infant, Newborn; D007247:Infertility, Female / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D050498:Live Birth / Q000453:epidemiology*; D008423:Maternal Age; D009865:Oocytes; D011247:Pregnancy; D018873:Pregnancy Rate; D011336:Probability; D011379:Prognosis; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data
keywords: Oocyte cryopreservation; individual patient data; meta-analysis; slow freezing; vitrification