title: [Chemoinformatics study on antibacterial activity of traditional Chinese medicine compounds].
abstract: OBJECTIVE
  The structure-activity relationship between traditional Chinese medicine (TCM) compounds and antibacterial activity was studied by chemoinformatics approach.
  
  
  METHODS
  Cytoscape and its plug-in ChemViz were applied to compute the 2D chemical structure similarity and topological parameter TPSA (topological molecular polar surface area), which measures cell permeability of chemicals, between TCM compounds and clinical antibacterials. The overall degree of structure similarity was then calculated and represented by E-value for the eight categories of TCM compounds and the known antibacterials.
  
  
  RESULTS
  Our results indicated that flavonoids showed good structural similarity with antibacterials and appropriate cell permeability, compared with those of the TCM compounds of the other categories. As flavonoids were featured by good drug safety, it suggested that they can be regarded as the preferred lead compounds skeleton structure source for further antibacterials synthesis.
  
  
  CONCLUSIONS
  The application of chemoinformatics helps explore the structure-activity relationship between TCM compounds and the antibacterial activity and search for suitable antibacterial lead compounds skeleton structure source.
authors.affiliation: Department of Pharmacy, Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China. rhqzxg@163.com
authors.forename: Kun
authors.initials: K
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Zhuo-Ran
authors.initials: ZR
authors.lastname: Zhang
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Guan
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Pu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D048088:Informatics / Q000379:methods*; D008516:Medicine, Chinese Traditional; D012984:Software; D013223:Statistics as Topic; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents