title: [Does multiple myeloma response to induction therapy depend on plasma cell IL6 receptor gene expression?].
abstract: BACKGROUND
  Interleukine 6 (IL-6) is the most important cytokine involved in malignant plasma cells growth and survival.
  
  
  OBJECTIVE
  To analyse bone marrow plasma cells IL6 receptor gene expression in both multiple myeloma patients at diagnosis and healthy bone marrow donors.
  
  
  METHODS
  Clinical and biological patients' features and responses to Dexamethasone-Thalidomide induction therapy were gathered. 47 patients and 16 case controls were analyzed: Bone marrow plasma cells were isolated; and IL6 receptor gene expression was quantified using Taqman quantitative PCr technology and 2-ΔCT formula.
  
  
  RESULTS
  Quantitative and qualitative IL6 receptor gene expression were negatively correlated with the degree of response to therapy (p= 0.02). In this study, plasma cells IL6 receptor gene expression seems to be decisive in predicting the response to treatment.
  
  
  CONCLUSIONS
  Understanding the mechanisms involved in plasma cells IL6 receptor gene expression may offer a better appreciation of the physiopathologic and anti-oncogenic ways of drug resistance in multiple myeloma and consequently the discovery of new specific drugs.
authors.forename: Ines
authors.initials: I
authors.lastname: Safra
authors.forename: Saloua
authors.initials: S
authors.lastname: Ladeb
authors.forename: Nour
authors.initials: N
authors.lastname: Skouri
authors.forename: Slah
authors.initials: S
authors.lastname: Ouerhani
authors.forename: Amina
authors.initials: A
authors.lastname: Ben Amor
authors.forename: Samia
authors.initials: S
authors.lastname: Menif
authors.forename: Amel
authors.initials: A
authors.lastname: Lakhal
authors.forename: Lamia
authors.initials: L
authors.lastname: Torjemane
authors.forename: Tarek
authors.initials: T
authors.lastname: Ben Othman
authors.forename: Abdeladhim
authors.initials: A
authors.lastname: Ben Abdelahim
authors.forename: Melika
authors.initials: M
authors.lastname: Ben Ahmed
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D006801:Humans; D060828:Induction Chemotherapy; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy*; D010950:Plasma Cells / Q000378:metabolism*; D011446:Prospective Studies; D019947:Receptors, Interleukin-6 / Q000235:genetics* / Q000378:metabolism
chemical_list: D019947:Receptors, Interleukin-6