title: Influence of mu-opioid receptor variant on morphine use and self-rated pain following abdominal hysterectomy.
abstract: A common variant in the mu-opioid receptor gene (OPRM1) has been associated with response to opioid analgesia. Our previous data revealed significantly higher amounts of morphine self-administered by patients carrying the 118G allele compared to those with the 118A allele after elective cesarean section. In this study, the association of this genetic variation with pressure pain, postoperative pain scores, and amount of morphine used was investigated in 973 patients undergoing scheduled total hysterectomy under general anesthesia. Preoperative pressure pain threshold and tolerance were also measured for most patients. For pressure pain, OPRM1 genotype was not significantly associated with either pain threshold or pain tolerance. Statistically significant associations were found for postoperative pain and the total amount of morphine used, with the GG group reporting higher pain scores and using the most morphine. When analysis was stratified by ethnic group, differences in weight-adjusted morphine for the 3 genotypic groups were also significant for the Chinese and Asian Indians. These results extend our previous finding on the association of higher self-reported pain and morphine use for acute postoperative pain with OPRM1 118G to patients who had total hysterectomy under general anesthesia.
  
  
  CONCLUSIONS
  In a large cohort of patients undergoing hysterectomy, we found large variability in the self-rated pain scores and the amount of morphine required for pain relief. Both are associated with OPRM1 genotypes and preoperative experimental pressure pain threshold. Experimental pressure pain tolerance is also associated with postoperative pain.
authors.affiliation: Department of Women's Anaesthesia, KK Women's and Children's Hospital, Singapore; KK Research Centre, KK Women's and Children's Hospital, Singapore.
authors.forename: Alex T
authors.initials: AT
authors.lastname: Sia
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Lim
authors.forename: Eileen C P
authors.initials: EC
authors.lastname: Lim
authors.forename: Cecilia E
authors.initials: CE
authors.lastname: Ocampo
authors.forename: Wai-Yee
authors.initials: WY
authors.lastname: Lim
authors.forename: Philip
authors.initials: P
authors.lastname: Cheong
authors.forename: Ene-Choo
authors.initials: EC
authors.lastname: Tan
mesh_terms: D000368:Aged; D000483:Alleles; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D044466:Asian People; D016001:Confidence Intervals; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000235:genetics* / Q000523:psychology; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011312:Pressure; D017450:Receptors, Opioid, mu / Q000235:genetics*; D057566:Self Report
chemical_list: D000701:Analgesics, Opioid; D017450:Receptors, Opioid, mu; D009020:Morphine; D004247:DNA
keywords: Hysterectomy; OPRM1; morphine; postoperative pain; pressure pain