title: In vivo minimally invasive interstitial multi-functional microendoscopy.
abstract: Developing minimally invasive methodologies for imaging of internal organs is an emerging field in the biomedical examination research. This paper introduces a new multi-functional microendoscope device capable of imaging of internal organs with a minimal invasive intervention. In addition, the developed microendoscope can also be employed as a monitoring device for measuring local hemoglobin concentration in blood stream when administrated into a blood artery. The microendoscope device has a total external diameter of only 200 μm and can provide high imaging resolution capability of more than 5,000 pixels. The device can detect features with a spatial resolution of less than 1 μm. The microendoscope has been tested both in-vitro as well as in-vivo in rats presenting a promising and powerful tool as a high resolution and minimally invasive imaging facility suitable for previously unreachable clinical modalities.
authors.affiliation: Clinical Photonics Laboratory, School in Advanced Optical Technologies (SAOT), Erlangen 91052, Germany. Asaf.Sh11@gmail.com
authors.forename: Asaf
authors.initials: A
authors.lastname: Shahmoon
authors.forename: Shiran
authors.initials: S
authors.lastname: Aharon
authors.forename: Oded
authors.initials: O
authors.lastname: Kruchik
authors.forename: Martin
authors.initials: M
authors.lastname: Hohmann
authors.forename: Hamutal
authors.initials: H
authors.lastname: Slovin
authors.forename: Alexandre
authors.initials: A
authors.lastname: Douplik
authors.forename: Zeev
authors.initials: Z
authors.lastname: Zalevsky
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D002645:Chickens; D004724:Endoscopy; D004867:Equipment Design; D045604:Extracellular Fluid; D049452:Green Fluorescent Proteins / Q000378:metabolism*; D057809:HEK293 Cells; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D057054:Molecular Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D051381:Rats
chemical_list: D006454:Hemoglobins; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins