title: Glycobiology of cell death: when glycans and lectins govern cell fate.
abstract: Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death. Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings.
authors.affiliation: Avram and Stella Goren-Goldstein, Department of Biotechnology Engineering, Faculty of Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
authors.forename: R G
authors.initials: RG
authors.lastname: Lichtenstein
authors.forename: G A
authors.initials: GA
authors.lastname: Rabinovich
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D006031:Glycosylation; D006801:Humans; D037102:Lectins / Q000502:physiology*; D011134:Polysaccharides / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D037102:Lectins; D011134:Polysaccharides