title: Oral mucoceles: a clinical, histopathological and immunohistochemical study.
abstract: The aim of study was to evaluate the clinicopathological features of oral mucoceles and the immunohistochemical expression of cellular and extracellular matrix components in these lesions. One hundred cases of oral mucoceles were examined for clinicopathological features. The expression of mast cell tryptase, CD68, MMP-1 (matrix metalloproteinase-1), MMP-9 (matrix metalloproteinase-9) and CD34 was investigated immunohistochemically in 32 cases. The lesions arose as nodules or blisters of variable color. The mean age was 23.2 years and a higher male frequency was observed. The most common locations were the lower lip (92%), followed by the floor of the mouth (7%), and palate (1%). The lesion size ranged from 0.4 to 3.0cm. Unusual histopathological findings as superficial mucoceles (n=16, 16%), pseudopapillary projections (n=3, 3%), epithelioid histiocytes (n=4, 4%), multinucleated giant cells (n=1, 1%) and myxoglobulosis (n=9, 9%) were also seen. Mast cells and CD68-positive macrophages, MMP-1, MMP-9 and CD34-positive blood vessels were seen in all cases. A significant association was seen between mast cells and MMP-1 (p=0.03) and between macrophages and MMP-1 (p=0.01). This study provided important insight into the demographic and histopathological occurrence of oral mucoceles. The tissue remodeling seen in these lesions mainly involved the migration and interaction of mast cells, macrophages and MMP-1.
authors.affiliation: Postgraduate Program in Human Pathology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
authors.forename: Jamile Gomes
authors.initials: JG
authors.lastname: Conceição
authors.affiliation: Postgraduate Program in Human Pathology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil; Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.
authors.forename: Clarissa Araújo
authors.initials: CA
authors.lastname: Gurgel
authors.affiliation: Postgraduate Program in Human Pathology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil; Laboratory of Pathology and Biology Molecular, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
authors.forename: Eduardo Antônio Gonçalves
authors.initials: EA
authors.lastname: Ramos
authors.affiliation: Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.
authors.forename: Flávia Caló
authors.initials: FC
authors.lastname: De Aquino Xavier
authors.affiliation: Postgraduate Program in Human Pathology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
authors.forename: Caroline Brandi
authors.initials: CB
authors.lastname: Schlaepfer-Sales
authors.affiliation: Department of Dental Public Health, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.
authors.forename: Maria Cristina Teixeira
authors.initials: MC
authors.lastname: Cangussu
authors.affiliation: Department of Periodontics, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.
authors.forename: Patrícia Ramos
authors.initials: PR
authors.lastname: Cury
authors.affiliation: Department of Stomatology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.
authors.forename: Luciana Maria Pedreira
authors.initials: LM
authors.lastname: Ramalho
authors.affiliation: Postgraduate Program in Human Pathology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil; Laboratory of Oral Surgical Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil. Electronic address: jeanpatol@gmail.com.
authors.forename: Jean Nunes
authors.initials: JN
authors.lastname: Dos Santos
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D015703:Antigens, CD / Q000378:metabolism; D018952:Antigens, CD34 / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D009078:Mucocele / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule
keywords: Histopathology; Immunohistochemistry; Myxoglobulosis; Oral mucoceles