title: Cobalamin deficiency manifested with seizures, mood oscillations, psychotic features and reversible dementia in the absence of typical neurologic and hematologic signs and symptoms: a case report.
abstract: Cobalamin deficiency is associated with a wide spectrum of hematologic, neurologic, gastroenterologic and psychiatric disorders or symptoms. We report a case of a 50-year-old man with complex partial seizures with secondary generalization, mood oscillations and psychotic symptoms alternating with confusion and reversible dementia secondary to cobalamin deficiency in the absence of typical neurologic and/or hematologic symptoms and signs. Exclusion of epilepsy, acute, atrophic or expansive lesion of central nervous system and usual etiology associated with reversible dementia (infectious diseases, an endocrine etiology and deficiency of vitamins other than cobalamin); finding of cobalamin deficiency only and complete neuropsychiatric recovery after substitution, confirmed etiology. Typical and atypical psychiatric manifestations due to cobalamin deficiency that precede neurologic and/or hematologic signs and symptoms can recover completely after adequate replacement therapy.
authors.affiliation: University of Zagreb, "Vrapce" University Psychiatric Hospital, Department of Biological Psychiatry and Psychogeriatry, Zagreb, Croatia. maja.vilibic@gmail.com
authors.forename: Maja
authors.initials: M
authors.lastname: Vilibić
authors.forename: Vlado
authors.initials: V
authors.lastname: Jukić
authors.forename: Andelko
authors.initials: A
authors.lastname: Vidović
authors.forename: Petrana
authors.initials: P
authors.lastname: Brecić
mesh_terms: D002220:Carbamazepine / Q000008:administration & dosage; D003704:Dementia / Q000150:complications / Q000175:diagnosis*; D003975:Diazepam / Q000008:administration & dosage; D004569:Electroencephalography / Q000379:methods; D006220:Haloperidol / Q000008:administration & dosage; D006405:Hematology / Q000379:methods; D006801:Humans; D006879:Hydroxocobalamin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000150:complications / Q000175:diagnosis*; D009462:Neurology / Q000379:methods; D011618:Psychotic Disorders / Q000150:complications / Q000175:diagnosis*; D012640:Seizures / Q000150:complications / Q000175:diagnosis*; D014806:Vitamin B 12 Deficiency / Q000150:complications / Q000175:diagnosis*
chemical_list: D002220:Carbamazepine; D006220:Haloperidol; D003975:Diazepam; D006879:Hydroxocobalamin