title: Stem cell metabolism in tissue development and aging.
abstract: Recent advances in metabolomics and computational analysis have deepened our appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to be a mere consequence of the state of a cell, metabolism is now known to play a pivotal role in dictating whether a cell proliferates, differentiates or remains quiescent. Here, we review recent studies of metabolism in stem cells that have revealed a shift in the balance between glycolysis, mitochondrial oxidative phosphorylation and oxidative stress during the maturation of adult stem cells, and during the reprogramming of somatic cells to pluripotency. These insights promise to inform strategies for the directed differentiation of stem cells and to offer the potential for novel metabolic or pharmacological therapies to enhance regeneration and the treatment of degenerative disease.
authors.affiliation: Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: Ng
authors.initials: N
authors.lastname: Shyh-Chang
authors.forename: George Q
authors.initials: GQ
authors.lastname: Daley
authors.forename: Lewis C
authors.initials: LC
authors.lastname: Cantley
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000378:metabolism; D000818:Animals; D001755:Blastocyst / Q000166:cytology / Q000378:metabolism*; D002454:Cell Differentiation; D049109:Cell Proliferation; D016922:Cellular Senescence; D047108:Embryonic Development; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D006019:Glycolysis; D006801:Humans; D032448:Myoblasts, Skeletal / Q000166:cytology / Q000378:metabolism; D010085:Oxidative Phosphorylation; D018384:Oxidative Stress; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism*
keywords: Blastocyst metabolism; Hematopoietic progenitors; Metabolomics; Pluripotent stem cells; Reprogramming