title: Preparation and evaluation of SnO2-based 68Ge/68Ga generator made from 68Ge produced through (nat)Zn(α,xn) reaction.
abstract: (68)Ge was produced by (nat)Zn(α,xn)(68)Ge reaction and its production yield was 31.82 kBq/μAh (0.86 μCi/μAh) at the end of irradiation (EOI). A simple chromatographic method using a SnO2 column was employed to separate (68)Ge from the target material and the co-produced non-isotopic radioisotope impurities. (68)Ge retained in the column served as the (68)Ge/(68)Ga generator. Elution efficiency of the column was about 60%. First 2 ml of the eluate contained more than 95% of the elutable activity. Post-elution purification cum concentration was done with a small cation exchange resin column. The presence of the inactive tin ions in the (68)Ga eluate was determined by the ICP-OES technique and was found to be about 0.03 ppm. Radiochemical purity of the final (68)Ga preparation was more than 99.99% and it was found to be suitable for making complex with ethylenediamine-N,N,N',N'-tetrakis(methylene phosphonic acid) (EDTMP).
authors.affiliation: Radiopharmaceuticals Laboratory, Board of Radiation and Isotope Technology (BRIT), Variable Energy Cyclotron Centre (VECC), Kolkata 700064, India.
authors.forename: Sujata Saha
authors.initials: SS
authors.lastname: Das
authors.forename: Sankha
authors.initials: S
authors.lastname: Chattopadhyay
authors.forename: Md Nayer
authors.initials: MN
authors.lastname: Alam
authors.lastname: Madhusmita
authors.forename: Luna
authors.initials: L
authors.lastname: Barua
authors.forename: Malay Kanti
authors.initials: MK
authors.lastname: Das
mesh_terms: D005710:Gallium Radioisotopes / Q000737:chemistry*; D031315:Geranium / Q000737:chemistry*; D017971:Tin Compounds / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D005710:Gallium Radioisotopes; D017971:Tin Compounds; D015032:Zinc; C045358:stannic oxide
keywords: (68)Ge production; (68)Ge/(68)Ga generator; PET radioisotope generator; Post-elution purification; SnO(2) Chromatography column; α on zinc