title: Effect of interleukin-2 level and genetic variants on coronary artery disease.
abstract: Inflammation plays important roles in the development of atherosclerosis and coronary artery disease (CAD). Interleukin-2 (IL-2) is a proinflammatory cytokine and induces proliferation of T cells. The aim of the study was to understand the effect of IL-2 on the development of CAD from genetic polymorphism perspective and serum level perspective. IL-2 -330T/G and +114T/G polymorphisms were tested in 692 CAD cases and 723 healthy controls. IL-2 expression of these two polymorphisms was compared. Serum level of IL-2 in CAD patients and controls was analyzed. Data showed that prevalence of IL-2 -330GG genotype was significantly increased in CAD than in controls (p = 5.1 × 10(-6)). Function analysis revealed that subjects carrying IL-2 -330GG genotype had higher serum level of IL-2 than those with TG or TT genotypes (p < 0.01). Serum level of IL-2 in the study subjects was further analyzed, and results showed that CAD patients had significantly increased IL-2 level than healthy controls (p < 0.01). Also, cases with three vessels affected were observed to have higher IL-2 level than cases with one vessel affected (p < 0.05). These data suggested IL-2 polymorphism could affect the susceptibility to CAD by elevating protein expression, and serum level of IL-2 may be closed correlated with the development and progression of this disease.
authors.affiliation: Department of Cardiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Ding
authors.forename: Wenwu
authors.initials: W
authors.lastname: Gao
authors.forename: David H
authors.initials: DH
authors.lastname: Ostrodci
authors.forename: Zhiqing
authors.initials: Z
authors.lastname: He
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Song
authors.forename: Lan
authors.initials: L
authors.lastname: Ma
authors.forename: Chun
authors.initials: C
authors.lastname: Liang
authors.forename: Zonggui
authors.initials: Z
authors.lastname: Wu
mesh_terms: D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007376:Interleukin-2 / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013601:T-Lymphocytes / Q000166:cytology
chemical_list: C508594:IL2 protein, human; D007376:Interleukin-2