title: When untethered, something silent inside comes.
abstract: Heterochromatin usually is sequestered near the periphery and the nucleoli in mammalian nuclei. However, in terminally differentiated retinal rod cells of nocturnal mammals, heterochromatin instead accumulates in the interior, to give a so-called inside-out nuclear architecture. Solovei et al. now reports that in most cells, the lamin B receptor mediates peripheral localization early during development and that lamin A/C then takes over this tethering function during terminal differentiation. Furthermore, they show that the unique architecture of the nocturnal animal rod cell is caused by the absence of both tethers and can be phenocopied in LBR/lamin A/C double knockouts.
authors.affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: Joan C Ritland
authors.initials: JC
authors.lastname: Politz
authors.forename: Tobias
authors.initials: T
authors.lastname: Ragoczy
authors.forename: Mark
authors.initials: M
authors.lastname: Groudine
mesh_terms: D000818:Animals; D006570:Heterochromatin / Q000378:metabolism*; D034904:Lamin Type A / Q000378:metabolism*; D024510:Muscle Development; D032446:Myoblasts / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*
chemical_list: D006570:Heterochromatin; D034904:Lamin Type A; D018160:Receptors, Cytoplasmic and Nuclear
keywords: heterochromatin; muscle development; nuclear organization; nuclear periphery; terminal differentiation