title: From pathophysiology to novel antidepressant drugs: glial contributions to the pathology and treatment of mood disorders.
abstract: Several structural and cellular changes, including marked glial anomalies, have been observed in association with major depressive disorder. Here we review these cellular alterations and highlight the importance of glial cell pathology, especially astroglial dysfunction, in the pathophysiology of neuropsychiatric disorders with a particular interest in major depressive disorder. The functional role of astrocytes in glutamate uptake and glutamate/glutamine cycling is discussed, as is the deleterious effects of chronic stress on glial cell function. Lastly, we discuss the effect of antidepressants on glial cell function and the possibility of targeting glial cells in the quest to develop novel therapeutics.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA. gerard.sanacora@yale.edu
authors.forename: Gerard
authors.initials: G
authors.lastname: Sanacora
authors.forename: Mounira
authors.initials: M
authors.lastname: Banasr
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002450:Cell Communication / Q000187:drug effects; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy* / Q000473:pathology*; D009457:Neuroglia / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology
chemical_list: D000928:Antidepressive Agents