title: Nociceptinergic system as potential target in Parkinson's disease.
abstract: Nociceptinergic system has become an important target for drug development since the identification of the "orphan", opioid-like-1 receptor and the isolation of its endogenous agonist nociceptin. Involvement of nociceptinergic system has been verified in a wide range of pathophysiological processes. A large number of nociceptinergic agonists and antagonists with peptide and non-peptide structures have been developed. Several non-peptide nociceptinergic antagonists have recently shown effective on different animal models of parkinsonism. Neuropharmacological background for antiparkinsonian effect of nociceptinergic antagonists, experimental models with high predictive value, nociceptinergic antagonists shown to have potential effect in Parkinson's disease are summarized. Medicinal chemistry data (logP and TPSA) of the NOP receptor antagonists which are found to be effective in animal models of Parkinson's disease are provided.
authors.forename: Kornelia
authors.initials: K
authors.lastname: Tekes
authors.forename: Saeed
authors.initials: S
authors.lastname: Tariq
authors.forename: Ernest
authors.initials: E
authors.lastname: Adeghate
authors.forename: Rudolf
authors.initials: R
authors.lastname: Laufer
authors.forename: Farzad
authors.initials: F
authors.lastname: Hashemi
authors.forename: Afshan
authors.initials: A
authors.lastname: Siddiq
authors.affiliation: Department of Pharmacodynamics, H-1089 Nagyvarad ter 4, Budapest, Hungary.
authors.forename: Huba
authors.initials: H
authors.lastname: Kalasz
mesh_terms: D000818:Animals; D006801:Humans; D009292:Narcotic Antagonists; D018847:Opioid Peptides / Q000737:chemistry / Q000494:pharmacology*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism; D013329:Structure-Activity Relationship; D000094942:Nociceptin Receptor; D000097629:Nociceptin
chemical_list: D009292:Narcotic Antagonists; D018847:Opioid Peptides; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor; D000097629:Nociceptin; C000722283:OPRL1 protein, human