title: Persistent polyclonal B-cell lymphocytosis with splenomegaly: histologic description of 2 cases.
abstract: Persistent polyclonal B-cell lymphocytosis is a rare, benign lymphoproliferative disorder characterized by a stable, polyclonal CD19-positive CD5-negative lymphocytosis, the presence of binucleated lymphocytes in peripheral blood, and a polyclonal increase in serum immunoglobulin-M that may occasionally be accompanied by splenomegaly. Histopathologic diagnosis of these splenectomy specimens is difficult because of the massive spleen infiltration and the rarity of the descriptions of this condition. We describe the histopathologic findings from 2 splenectomy specimens. These included a partially preserved architecture with infiltration of the red pulp by small lymphocytes and partial replacement of the white pulp. Suggestions for identifying the disorder are made.
authors.affiliation: Department of Pathology, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain.
authors.forename: Azahara
authors.initials: A
authors.lastname: Martinez-Lopez
authors.forename: Santiago
authors.initials: S
authors.lastname: Montes-Moreno
authors.forename: Francisco
authors.initials: F
authors.lastname: Mazorra
authors.forename: Cesar
authors.initials: C
authors.lastname: Miranda-Vallina
authors.forename: Carlos
authors.initials: C
authors.lastname: Ulibarrena
authors.forename: Juan Luis Alfonso
authors.initials: JL
authors.lastname: Martin
authors.forename: Jose Miguel
authors.initials: JM
authors.lastname: Bosch
authors.forename: Valeria
authors.initials: V
authors.lastname: Peri
authors.forename: Ana
authors.initials: A
authors.lastname: Burdaspal
authors.forename: Montse
authors.initials: M
authors.lastname: Fernandez-Alvarez
authors.forename: Lidia
authors.initials: L
authors.lastname: Sanchez-Verde
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Piris
mesh_terms: D000328:Adult; D018941:Antigens, CD19 / Q000378:metabolism; D002999:Clone Cells; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000473:pathology; D008218:Lymphocytosis / Q000150:complications / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D013154:Spleen / Q000473:pathology* / Q000601:surgery; D013163:Splenomegaly / Q000150:complications / Q000473:pathology*
chemical_list: D018941:Antigens, CD19; D007075:Immunoglobulin M