title: IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis.
abstract: Interleukin (IL)-22 secreting CD4(+) T (Th22) cells and IL-22 are involved in the pathogenesis of autoimmune disease, but their role in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unclear. We measured the proportion of Th22, Th17, CD4(+)IL-22(+)IL-17A(+) T cells and serum IL-22 in NMO and MS patients. The proportion of Th22 cells, Th17 cells and serum IL-22 were increased in patients with NMO and MS. Our findings suggest that increased Th22 cells may play an important role in the pathogenesis of NMO and MS.
authors.affiliation: Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Xu
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Dai
authors.forename: Aimin
authors.initials: A
authors.lastname: Wu
authors.forename: Honghao
authors.initials: H
authors.lastname: Wang
authors.forename: Chen
authors.initials: C
authors.lastname: Cheng
authors.forename: Wei
authors.initials: W
authors.lastname: Qiu
authors.forename: Zhengqi
authors.initials: Z
authors.lastname: Lu
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Zhong
authors.forename: Yaqing
authors.initials: Y
authors.lastname: Shu
authors.forename: Allan G
authors.initials: AG
authors.lastname: Kermode
authors.forename: Xueqiang
authors.initials: X
authors.lastname: Hu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007378:Interleukins / Q000097:blood* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D009471:Neuromyelitis Optica / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D055815:Young Adult; D000097043:Interleukin-22
chemical_list: D015415:Biomarkers; D007378:Interleukins; D000097043:Interleukin-22
keywords: IL-22; IL-22 secreting CD4+ T cells; MS; NMO; Th22 cells