title: An electrochemical biosensor for clenbuterol detection and pharmacokinetics investigation.
abstract: Clenbuterol is a member of β2 adrenergic agonists, which is widely used not only as a food additive for livestocks, but also a kind of stimulant for athletes; however, the abuse of clenbuterol may pose a significant negative impact on human health. Since it is highly required to develop fast, sensitive and cost-effective method to determine clenbuterol level in the suspected urine or blood, we herein have fabricated an electrochemical biosensor for the determination of clenbuterol. Measurement of the species with the proposed biosensor can also have the advantages of simplicity, high sensitivity and selectivity. Moreover, the sensor can be directly used for clenbuterol determination in rat urine. We have further studied the pharmacokinetics of clenbuterol by using this proposed electrochemical biosensor, so a new tool to investigate pharmacokinetic is developed in this work.
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Bo
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhu
authors.forename: Peng
authors.initials: P
authors.lastname: Miao
authors.forename: Dong
authors.initials: D
authors.lastname: Pei
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Yue
authors.initials: Y
authors.lastname: Lou
authors.forename: Yongqian
authors.initials: Y
authors.lastname: Shu
authors.forename: Genxi
authors.initials: G
authors.lastname: Li
mesh_terms: D000318:Adrenergic beta-Agonists / Q000493:pharmacokinetics / Q000652:urine*; D000818:Animals; D015374:Biosensing Techniques; D002976:Clenbuterol / Q000493:pharmacokinetics / Q000652:urine*; D055664:Electrochemical Techniques; D004566:Electrodes; D005260:Female; D005506:Food Contamination; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D058573:Performance-Enhancing Substances / Q000493:pharmacokinetics / Q000652:urine*; D010984:Platinum / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D015813:Substance Abuse Detection
chemical_list: D000318:Adrenergic beta-Agonists; D058573:Performance-Enhancing Substances; D010984:Platinum; D006046:Gold; D002976:Clenbuterol