title: Aldosterone synthase gene (CYP11B2) -344C/T polymorphism contributes to the risk of recurrent cerebral ischemia.
abstract: BACKGROUND
  Accumulating evidence suggests that CYP11B2 rs1799998 (-344C/T) polymorphism is independently associated with an increased risk of stroke. Our aim was to determine whether -344C/T also predisposes to recurrent cerebral ischemia following in patients with symptomatic intracranial atherosclerosis disease (ICAD).
  
  
  METHODS
  Genotypes of the CYP11B2 -344C/T polymorphism were determined by polymerase chain reaction-restriction fragment length polymorphism. A total of 208 ICAD patients were enrolled and underwent a long-term clinical follow-up to detect the recurrent cerebral ischemia.
  
  
  RESULTS
  During a median follow-up time of 35 months, 40 recurrent strokes (19.2%) were documented. Kaplan-Meier and multivariable Cox regression analyses adjusted for age, gender, and other cardiovascular risk factors identified that the presence of the TT genotype within the CYP11B2 -344C/T polymorphism was associated with an increased risk of 1.98-fold for recurrent cerebral ischemia (the hazard ratio 1.98, 95% confidence interval 1.16-3.41; p=0.01).
  
  
  CONCLUSIONS
  Our findings suggest that the -344C/T polymorphism of the CYP11B2 gene confers an increased risk of recurrent cerebral ischemia.
authors.affiliation: Department of Neurology-Muscle, Brain Hospital of People's Hospital of Zhengzhou, Henan Province, China. jipeng1976@163.com
authors.forename: Peng
authors.initials: P
authors.lastname: Ji
authors.forename: Limin
authors.initials: L
authors.lastname: Jiang
authors.forename: Shuling
authors.initials: S
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.forename: Daopei
authors.initials: D
authors.lastname: Zhang
authors.forename: Shengqi
authors.initials: S
authors.lastname: Fu
authors.forename: Hongtao
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000208:ethnology / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000235:genetics; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012008:Recurrence; D012306:Risk
chemical_list: D019405:Cytochrome P-450 CYP11B2