title: The risk of thrombotic events in patients with liver cirrhosis.
abstract: OBJECTIVE
  To evaluate the incidence and risk factors for thrombotic events (deep vein thrombosis and portal vein thrombosis) in patients with liver cirrhosis.
  
  
  METHODS
  we studied patients diagnosed with liver cirrhosis admitted in our department between January 2010-December 2011, which were divided in two groups: liver cirrhosis with thrombotic events and without thrombotic events.
  
  
  RESULTS
  we included 3108 patients, the incidence of deep vein thrombosis was 0.99% and portal vein thrombosis was 1.51%, the incidence of all thrombotic events was 2.5%. In the univariate analysis serum albumin was significantly lower in cases than controls, and MELD score, mean platelet volume were higher in cases than controls. The presence of sepsis and diabetes mellitus were demonstrated like risk factors by the univariate analysis. In multivariate analysis, albumin level< 3mg/dl (HR=1.65, CI 1.10-2.51, p=0.018) and MELD score >13 (HR=2.94, CI 1.61-5.47, p=0.001) remained independently predictive of thrombotic events.
  
  
  CONCLUSIONS
  The incidence of thrombotic events in patients with liver cirrhosis was 2.5%. Low serum albumin and high MELD score could predict the development of thrombotic events in patients with liver cirrhosis.
authors.affiliation: University of Medicine and Pharmacy Grigore T Popa Iasi, Faculty of Medicine.
authors.forename: Irina
authors.initials: I
authors.lastname: Gîrleanu
authors.forename: Anca
authors.initials: A
authors.lastname: Trifan
authors.forename: Camelia
authors.initials: C
authors.lastname: Cojocariu
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Sîngeap
authors.forename: C
authors.initials: C
authors.lastname: Sfarti
authors.forename: C
authors.initials: C
authors.lastname: Stanciu
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008103:Liver Cirrhosis / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000473:pathology; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D020246:Venous Thrombosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*