title: Endothelial cell protein C receptor (EPCR) is expressed by lung carcinoma and correlated with clinical parameters.
abstract: BACKGROUND
  Endothelial cell protein C receptor (EPCR) is a cellular receptor for protein C and activated protein C (APC). In view of convincing evidence, it seems that EPCR, beyond its effects on coagulation and inflammation, could interfere with carcinogenesis.
  
  
  METHODS
  In the present study, we investigated EPCR expression in 60 lung carcinoma tissues and 37 para-carcinoma tissues, and analyzed the relationship between EPCR expression and histopathological parameters, clinical parameters, and vascular density.
  
  
  RESULTS
  In vitro, culturing lung cancer cell lines constitutively expressed EPCR at the level of mRNA and protein. The pathologic results clearly demonstrated that EPCR expression, including membranous and cytoplasmic staining, was significantly higher in carcinoma than that in the para-carcinoma tissues. The EPCR expression was therefore related to tumor size, lymph node metastasis as well as TNM stage. The expression of EPCR was also significantly correlated with microvessel density (MVD).
  
  
  CONCLUSIONS
  These observations provide evidence that EPCR may be involved in the carcinogenesis of lung cancer. It is suggested that EPCR may be a useful biomarker for evaluating the clinical status of lung cancer.
authors.affiliation: Respiratory Department, The First Affiliated Hospital of Soochow University, Suzhou, China. hwsdfyy@163.com
authors.forename: Wei
authors.initials: W
authors.lastname: Heng
authors.forename: Chuan-Yong
authors.initials: CY
authors.lastname: Mu
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Jian-An
authors.initials: JA
authors.lastname: Huang
authors.forename: Zhao-Yue
authors.initials: ZY
authors.lastname: Wang
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D000074283:Endothelial Protein C Receptor; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D015703:Antigens, CD; D000074283:Endothelial Protein C Receptor; C478370:PROCR protein, human; D012333:RNA, Messenger; D011956:Receptors, Cell Surface