title: Influence of migraine and of migraine aura on balance and mobility--a controlled study.
abstract: BACKGROUND
  Migraine, especially migraine with aura (MA), appears to be a risk factor for ischemic lesions in the posterior fossa. The clinical relevance of the lesions is uncertain. Accordingly, herein, we identified individuals with MA, migraine without aura (MO), and without migraine (controls) in order to investigate their balance and mobility.
  
  
  METHODS
  Participants were selected among patients seen in an outpatient headache clinic. Controls had no history of headache. Balance was assessed by measuring the oscillation area using force plates and mobility was assessed with the Timed Up and Go test.
  
  
  RESULTS
  Of 92 volunteers, 31 had MO (38 ± 10 years), 31 had MA (37 ± 8), and 30 were controls (33 ± 9). Subjects with MA had larger oscillation area (2.5 ± 1.4 cm(2) and 3.7 ± 2.9 cm(2) ) relative to those with MO (2.0 ± 1.7 cm(2) and 2.1 ± 2.2 cm(2) , P = .02) and controls (1.5 ± 0.8 cm(2) and 1.7 ± 1.2 cm(2) , P < .001) when standing in the bipodal position, respectively, with opened and closed eyes. MA was different with MO while standing in the unipodal position with eyes opened (right leg 6.7 ± 2.5 cm(2) vs 4.9 ± 1.7 cm(2) , P = .002; left leg 6.5 ± 2.7 cm(2) and 4.8 ± 1.4 cm(2) , P = .008). No differences were seen between MA and MO regarding the Timed Up and Go, although both groups were different than controls (8.5 seconds. and 6.5 seconds, P < .001; 8.2 and 6.5 seconds, P < .01, respectively). Dizziness symptoms happened in 25/31 (80%) of those with MA and 20/31 (65%) with MO, relative to 2/30 (6.5%) in controls (P < .0001 and P < .001).
  
  
  CONCLUSIONS
  Aura negatively affects static balance and mobility in individuals with migraine. Dizziness is a prevalent symptom in this population.
authors.affiliation: Department of Biomechanics, Medicine and Locomotor Apparatus Rehabilitation, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
authors.forename: Gabriela F
authors.initials: GF
authors.lastname: Carvalho
authors.forename: Thais C
authors.initials: TC
authors.lastname: Chaves
authors.forename: Fabíola
authors.initials: F
authors.lastname: Dach
authors.forename: Carina F
authors.initials: CF
authors.lastname: Pinheiro
authors.forename: Maria C
authors.initials: MC
authors.lastname: Gonçalves
authors.forename: Lidiane L
authors.initials: LL
authors.lastname: Florencio
authors.forename: Karen S
authors.initials: KS
authors.lastname: Ferreira
authors.forename: Marcelo E
authors.initials: ME
authors.lastname: Bigal
authors.forename: Débora
authors.initials: D
authors.lastname: Bevilaqua-Grossi
mesh_terms: D000328:Adult; D004244:Dizziness / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D020325:Migraine with Aura / Q000175:diagnosis / Q000503:physiopathology*; D020326:Migraine without Aura / Q000175:diagnosis / Q000503:physiopathology*; D010865:Pilot Projects; D004856:Postural Balance / Q000502:physiology*; D016138:Walking / Q000502:physiology*; D055815:Young Adult
keywords: Timed Up and Go; balance; headache; migraine with aura; postural control