title: Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria.
abstract: BACKGROUND
  Autoimmune mechanisms play a role in the pathophysiology of chronic urticaria. As the genetic background of autoimmunity is well proven, the role of genetics in chronic urticaria is hypothesised.
  
  
  METHODS
  153 unrelated chronic spontaneous urticaria patients with a positive result of autologous serum skin test were included into the study, as were 115 healthy volunteers as control group. In all subjects we analysed CCR2 G190A and CCR5 d32 polymorphisms.
  
  
  RESULTS
  We noticed higher prevalence of CCR2 A allele as well as lower frequency of CCR5 d32 in chronic urticaria group in comparison to control group, with borderline statistical significance. Additionally, we assumed haplotype Gd statistically significant negative chronic urticaria association with tendency to higher frequency of Aw haplotype in this group.
  
  
  CONCLUSIONS
  The results of our study imply the role of autoimmune components in chronic urticaria pathogenesis and present chronic urticaria as possibly genetically related disorder.
authors.affiliation: Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland. Electronic address: zbrzoza@mp.pl.
authors.forename: Z
authors.initials: Z
authors.lastname: Brzoza
authors.affiliation: Chair and Clinical Department of Internal Diseases, Diabetology and Nephrology, Medical University of Silesia, Katowice, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Grzeszczak
authors.affiliation: Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Rogala
authors.affiliation: Chair and Clinical Department of Internal Diseases, Diabetology and Nephrology, Medical University of Silesia, Katowice, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Trautsolt
authors.affiliation: Chair and Clinical Department of Internal Diseases and Nephrodiabetology, Medical University of Łódź, Łódź, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Moczulski
mesh_terms: D000328:Adult; D015551:Autoimmunity / Q000235:genetics* / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D054390:Receptors, CCR2 / Q000235:genetics* / Q000276:immunology; D019713:Receptors, CCR5 / Q000235:genetics* / Q000276:immunology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014581:Urticaria / Q000235:genetics* / Q000276:immunology; D055815:Young Adult
chemical_list: C515334:CCR2 protein, human; C584933:CCR5 protein, human; D054390:Receptors, CCR2; D019713:Receptors, CCR5
keywords: CCR2; CCR5; Chronic urticaria; Polymorphism