title: Rheological studies of polysaccharides for skin scaffolds.
abstract: Polysaccharide hydrogels are good candidates for skin scaffolds because of their inherent biocompatibility and water transport properties. In the current study, hydrogels were made from a mixture of four polysaccharides: xanthan gum, konjac gum, iota-carrageenan, and kappa-carrageenan. Gel formation, strength, and structure of these polysaccharides were studied using rheological and thermal techniques. All gel samples studied were strong gels at all times because of the gradual water loss. However, after 12 h of storage, elastic (G') and loss (G'') moduli of hydrogel mixture containing all the ingredients is of one to two orders of magnitude greater than that of mixtures not containing either xanthan gum or iota-carrageenan, which confirmed the varied levels of gel strength. This is mainly due to the rate of water loss in each of these mixtures, resulting in gels of varying structures and dynamic moduli over a period of time. Iota-carrageenan and xanthan gum differ in their effect on gel strength and stability in combination with konjac gum and kappa-carrageenan.
authors.affiliation: Department of Physics, Center for Polymer Fluid Dynamics, Central Michigan University, Mt. Pleasant, Michigan, 48859; Science of Advanced Materials, Central Michigan University, Mt. Pleasant, Michigan, 48859.
authors.forename: Nalinda
authors.initials: N
authors.lastname: Almeida
authors.forename: Anja
authors.initials: A
authors.lastname: Mueller
authors.forename: Stanley
authors.initials: S
authors.lastname: Hirschi
authors.forename: Leela
authors.initials: L
authors.lastname: Rakesh
mesh_terms: D002152:Calorimetry, Differential Scanning; D055119:Elastic Modulus / Q000187:drug effects; D020100:Hydrogels / Q000737:chemistry; D006860:Hydrogen Bonding; D008970:Molecular Weight; D011134:Polysaccharides / Q000494:pharmacology*; D012212:Rheology / Q000187:drug effects*; D012867:Skin / Q000187:drug effects*; D013696:Temperature; D013818:Thermogravimetry; D013997:Time Factors; D054457:Tissue Scaffolds / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D020100:Hydrogels; D011134:Polysaccharides; D014867:Water
keywords: biocompatibility; degradation; hydrogel; rheology; skin scaffold