title: Effect of sleeve gastrectomy on postprandial lipoprotein metabolism in morbidly obese patients.
abstract: BACKGROUND
  Obesity is associated with abnormal fasting and postprandial lipids, which may link obesity with atherosclerosis. We explored fasting and postprandial lipids in morbidly obese patients treated with sleeve gastrectomy and in control subjects.
  
  
  METHODS
  After fasting for 12 h 15 morbidly obese patients (BMI 51.4±6.5 kg/m2, 43.7±12.6 years) received a standardized oral fat load before and 3 months after bariatric surgery (sleeve gastrectomy). Controls (n=9, BMI 23.1±1.4 kg/m²) were studied once. Plasma was obtained fasting and then postprandially every 2 h for 8 h. Triglycerides (TG), chylomicron-TG (CM-TG), VLDL/chylomicron-remnant (VLDL/CR)-TG, cholesterol, LDL-cholesterol, VLDL/CR-cholesterol and HDL-cholesterol were isolated by ultracentrifugation at each time point. Postprandial values were expressed as area under the curve (AUC) and incremental area under the curve (iAUC). In addition, fasting glucose and insulin values and HOMA-IR-Index was measured (n=14).
  
  
  RESULTS
  Compared to controls morbidly obese patients had elevated TG and slightly altered postprandial lipids. Following surgery (weight loss 23.4 kg±6.2 kg; p<0.001) fasting TG (-19.1%; p=0.04), VLDL/CR-TG (-20.0%; p=0.05) decreased significantly, while fasting cholesterol, VLDL-, HDL- and LDL-cholesterol did not change. AUC and iAUC decreased significantly for VLDL/CR-TG (-20.4%, p=0.04 and -38.5%, p=0.04, respectively). Neither fasting nor postprandial changes correlated with the change in weight. In patients with preoperatively elevated TG (>150 mg/dl) a similar pattern was observed. Fasting insulin and HOMA were reduced significantly (-51.9%; p=0.004 and -47.9%; p=0.011).
  
  
  CONCLUSIONS
  Three months after sleeve gastrectomy fasting and postprandial lipoprotein metabolism and glucose metabolism is improved in morbidly obese patients. The potential mechanisms may relate to decreased caloric intake but also to hormonal changes.
authors.affiliation: Medical Department II-Grosshadern, Ludwig-Maximilians University Munich, Munich, Germany. elisa.waldmann@med.uni-muenchen.de
authors.forename: Elisa
authors.initials: E
authors.lastname: Waldmann
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Hüttl
authors.forename: Burkhard
authors.initials: B
authors.lastname: Göke
authors.forename: Reinhold
authors.initials: R
authors.lastname: Lang
authors.forename: Klaus G
authors.initials: KG
authors.lastname: Parhofer
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood; D050110:Bariatric Surgery; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D002914:Chylomicrons / Q000097:blood; D005260:Female; D005743:Gastrectomy; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood; D007328:Insulin / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000473:pathology / Q000601:surgery*; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D002914:Chylomicrons; D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides