title: Long-term tumor control of benign intracranial tumors after Gamma Knife radiosurgery in 280 patients followed more than 5 years.
abstract: The objective of the study was to assess the long-term radiological outcome of benign intracranial tumors (BIT) after Gamma Knife radiosurgery. We report the radiological outcome of 280 patients who underwent radiosurgical irradiation for BIT in a single center. Our series included 120 meningiomas, 139 vestibular schwannomas, 12 other schwannomas and 9 pituitary adenomas. Serial imaging studies were performed after irradiation for at least 5 years for all patients. The median tumor volume was 1.9 cc, and the median margin dose was 12 Gy. After a median follow-up of 6.8 years, the tumor control rate was 92.1%: tumor decreased in 176 cases (62.9%), remained unchanged in 82 lesions (29.3%) and increased in 22 cases (7.9%). The actuarial tumor control rate was 93.2% at 5 years, 92.3% at 7.5 years and 91.0% at 10 years. No atypical or malignant transformation of irradiated tumors occured during the follow-up period. Gamma Knife radiosurgery provides a high rate of tumor control for BIT even in the medium to long-term.
authors.affiliation: Department of Neurosurgery, Gamma Knife Center, University Hospital Erasme, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium, nmassage@ulb.ac.be.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Massager
authors.forename: Françoise
authors.initials: F
authors.lastname: De Smedt
authors.forename: Daniel
authors.initials: D
authors.lastname: Devriendt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000601:surgery*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D012189:Retrospective Studies; D013995:Time; D016896:Treatment Outcome; D055815:Young Adult