title: Characterizing vaccine responses using host genomic and transcriptomic analysis.
abstract: Vaccines have had a profound influence on human health with no other health intervention rivaling their impact on the morbidity and mortality associated with infectious disease. However, the magnitude and persistence of vaccine immunity varies considerably between individuals, a phenomenon that is not well understood. Recent studies have used contemporary technologies to correlate variation in the genome and transcriptome to immunological measures of vaccine responsiveness. These approaches have provided fresh insight into the intrinsic factors determining the potency and duration of vaccine-induced immunity. The fundamental challenge will be to translate these findings into innovative and pragmatic strategies to develop new and more effective vaccines.
authors.affiliation: Department of Paediatrics, University of Oxford, and the National Institute for Health Research Oxford Biomedical Research Centre, United Kingdom.
authors.forename: Daniel
authors.initials: D
authors.lastname: O'Connor
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Pollard
mesh_terms: D020869:Gene Expression Profiling; D055106:Genome-Wide Association Study; D023281:Genomics / Q000379:methods*; D006801:Humans; D055261:Immunogenetic Phenomena; D014612:Vaccines / Q000276:immunology* / Q000494:pharmacology*
chemical_list: D014612:Vaccines
keywords: genomics; heritability; immunogenetics; transcriptomics; vaccine immunology