title: Heme oxygenase-1 expression in peripheral blood mononuclear cells correlates with disease activity in multiple sclerosis.
abstract: Multiple sclerosis (MS) is an immunoinflammatory disease that affects the central nervous system. Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. We show in this study that HO-1 expression is reduced in PBMCs of MS patients and that during exacerbation of the disease there is a significant downregulation of this enzyme. We conclude that HO-1 may play a significant role in the maintenance of immune homeostasis which is disrupted in autoimmune disorders, such as MS.
authors.affiliation: Department of Bio-medical Sciences, University of Catania, Catania, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Fagone
authors.forename: Francesco
authors.initials: F
authors.lastname: Patti
authors.forename: Katia
authors.initials: K
authors.lastname: Mangano
authors.forename: Santa
authors.initials: S
authors.lastname: Mammana
authors.forename: Marinella
authors.initials: M
authors.lastname: Coco
authors.forename: Chafia
authors.initials: C
authors.lastname: Touil-Boukoffa
authors.forename: Tinatin
authors.initials: T
authors.lastname: Chikovani
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Marco
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Nicoletti
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D051547:Heme Oxygenase-1 / Q000096:biosynthesis* / Q000097:blood*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000201:enzymology* / Q000473:pathology
chemical_list: C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1
keywords: Autoimmunity; HO-1; IFN-beta; Multiple sclerosis