title: Hypoxia, notch signalling, and prostate cancer.
abstract: The notch signalling pathway is involved in differentiation, proliferation, angiogenesis, vascular remodelling, and apoptosis. Deregulated expression of notch receptors, ligands, and targets is observed in many solid tumours, including prostate cancer. Hypoxia is a common feature of prostate tumours, leading to increased gene instability, reduced treatment response, and increased tumour aggressiveness. The notch signalling pathway is known to regulate vascular cell fate and is responsive to hypoxia-inducible factors. Evidence to date suggests similar, therapeutically exploitable, behaviour of notch-activated and hypoxic prostate cancer cells.
authors.affiliation: Radiation and Urologic Oncology, Prostate Molecular Oncology Research Group, Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin, Trinity Centre for Health Sciences, James's Street, Dublin 8, Ireland. marignol@tcd.ie
authors.forename: Laure
authors.initials: L
authors.lastname: Marignol
authors.forename: Karla
authors.initials: K
authors.lastname: Rivera-Figueroa
authors.forename: Thomas
authors.initials: T
authors.lastname: Lynch
authors.forename: Donal
authors.initials: D
authors.lastname: Hollywood
mesh_terms: D000818:Animals; D015687:Cell Hypoxia / Q000502:physiology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D008297:Male; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D051880:Receptors, Notch / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D051793:Hypoxia-Inducible Factor 1; D051880:Receptors, Notch