title: Porous starch: a novel carrier for solubility enhancement of carbamazepine.
abstract: To circumvent the solubility-related issues associated with Biopharmaceutics Classification System class II drugs, a novel porous carrier has been developed. In the present study, a process for preparation of porous starch (PS) is demonstrated. The process briefly comprises of translucent gel preparation followed by solvent replacement, drying, and sizing. Carbamazepine (CBZ) was used as a drug candidate to exhibit solubility enhancement potential of PS. PS and CBZ-loaded PS (CBZ-PS) systems were characterized with respect to IR, DSC, XRD, SEM, and dissolution kinetic studies. PS-CBZ was found to follow a Fickian behavior during dissolution. In vivo studies conducted in mice displayed a superior performance of CBZ-PS as compared to neat CBZ.
authors.affiliation: Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga (E), Mumbai, 400019, India. tarique.meer@gmail.com
authors.forename: Meer Tarique
authors.initials: MT
authors.lastname: Ali
authors.forename: Ritesh
authors.initials: R
authors.lastname: Fule
authors.forename: Ajay
authors.initials: A
authors.lastname: Sav
authors.forename: Purnima
authors.initials: P
authors.lastname: Amin
mesh_terms: D000927:Anticonvulsants / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002220:Carbamazepine / Q000737:chemistry*; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D033362:Powder Diffraction; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine