title: Aripiprazole monotherapy in an adolescent worsens psychosis.
abstract: Early detection and treatment of early onset schizophrenia (EOS) can lead to better outcome. Aripiprazole, a partial agonist of dopamine and a second generation antipsychotic, has been approved specifically for treatment of children with schizophrenia of aged 13-17 years. Though the use of this drug in adults may be associated with worsening of psychosis in occasional cases, no such data is available in adolescents. We report a case of EOS, who had worsening of psychosis with aripiprazole monotherapy. We discuss the possible mechanisms and clinical implications relevant in adolescents, and alert the clinicians to be vigilant in monitoring the patients on aripiprazole, especially after an increase in the dose of this medication.
authors.affiliation: Department of Preventive and Social Medicine, Jawaharlal Nehru Medical College, Sawangi Meghe, Wardha, India.
authors.forename: Mahima
authors.initials: M
authors.lastname: Panigrahi
authors.forename: Susanta Kumar
authors.initials: SK
authors.lastname: Padhy
authors.forename: Rajesh
authors.initials: R
authors.lastname: Rathi
mesh_terms: D000293:Adolescent; D000367:Age Factors; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000068180:Aripiprazole; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects*; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000503:physiopathology*; D015363:Quinolones / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole
keywords: Aripiprazple; adolescent; early onset schizophrenia; worsening of psychosis