title: Effects of directly autotransplanted tibial bone marrow aspirates on bone regeneration and osseointegration of dental implants.
abstract: OBJECTIVE
  Aim of the pilot trial was to evaluate applicability and effects of directly autotransplanted tibial bone marrow (BM) aspirates on the incorporation of porous bovine bone mineral in a sinus lift model and on the osseointegration of dental implants.
  
  
  METHODS
  Six edentulous patients with bilaterally severely resorbed maxillae requiring sinus augmentation and implant treatment were included. During surgery, tibial BM was harvested and added to bone substitute material (Bio-Oss(®) ) at the randomly selected test site. At control sites, augmentation was performed with Bio-Oss(®) alone. The cellular content of each BM aspirate was checked for multipotency and surface antigen expression as quality control. Histomorphometric analysis of biopsies from the augmented sites after 3 and 6 months (during implantation) was used to evaluate effects on bone regeneration. Osseointegration of implants was evaluated with Periotest(®) and radiographic means.
  
  
  RESULTS
  Multipotent cellular content in tibial BM aspirates was comparable to that in punctures from the iliac crest. No significant difference in amount of new bone formation and the integration of bone substitute particles was detected histomorphometrically. Periotest(®) values and radiographs showed successful osseointegration of inserted implants at all sites.
  
  
  CONCLUSIONS
  Directly autotransplanted tibial BM aspirates did not show beneficial regenerative effects in the small study population (N = 6) of the present pilot trial. However, the proximal tibia proved to be a potential donor site for small quantities of BM. Future trials should clarify whether concentration of tibial BM aspirates could effect higher regenerative potency.
authors.affiliation: Department of Oral Surgery and Radiology, School of Dentistry, Medical University of Graz, Graz, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Payer
authors.forename: Birgit
authors.initials: B
authors.lastname: Lohberger
authors.forename: Dirk
authors.initials: D
authors.lastname: Strunk
authors.forename: Karoline M
authors.initials: KM
authors.lastname: Reich
authors.forename: Stephan
authors.initials: S
authors.lastname: Acham
authors.forename: Norbert
authors.initials: N
authors.lastname: Jakse
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001706:Biopsy; D016026:Bone Marrow Transplantation / Q000379:methods*; D001861:Bone Regeneration; D002417:Cattle; D003758:Dental Implantation, Endosseous; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000601:surgery*; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use*; D016348:Osseointegration; D010865:Pilot Projects; D011786:Quality Control; D059546:Sinus Floor Augmentation / Q000379:methods*; D013977:Tibia; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: C077540:Bio-Oss; D008903:Minerals
keywords: bone marrow aspirates; proximal tibia; sinus augmentation