title: Characterization and antimicrobial property of poly(acrylic acid) nanogel containing silver particle prepared by electron beam.
abstract: In this study, we developed a one step process to synthesize nanogel containing silver nanoparticles involving electron beam irradiation. Water-soluble silver nitrate powder is dissolved in the distilled water and then poly(acrylic acid) (PAAc) and hexane are put into this silver nitrate solution. These samples are irradiated by an electron beam to make the PAAc nanogels containing silver nanoparticles (Ag/PAAc nanogels). The nanoparticles were characterized by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). In addition, the particle size and zeta-potential were confirmed by a particle size analyzer (PSA). The antibacterial properties of the nanogels were evaluated by paper diffusion test. The Ag/PAAc nanogels had an antibacterial effect against Escherichia coli and Staphylococcus aureus. The nanogels also demonstrated a good healing effect against diabetic ulcer. The size of the Ag/PAAc nanogels decreased with increasing irradiation doses, and the absolute value of the zeta potential increased with increasing irradiation doses. Also, the Ag/PAAc nanogels exhibited good antibacterial activity against both Gram-negative and Gram-positive bacteria. In in vivo wound healing, the Ag/PAAc nanogels have a good healing effect.
authors.affiliation: Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong Jeongeup-si, Jeollabuk-do 580-185, Korea. jspark75@kaeri.re.kr.
authors.forename: Jong-Bae
authors.initials: JB
authors.lastname: Choi
authors.forename: Jong-Seok
authors.initials: JS
authors.lastname: Park
authors.forename: Myung-Seob
authors.initials: MS
authors.lastname: Khil
authors.forename: Hui-Jeong
authors.initials: HJ
authors.lastname: Gwon
authors.forename: Youn-Mook
authors.initials: YM
authors.lastname: Lim
authors.forename: Sung-In
authors.initials: SI
authors.lastname: Jeong
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Shin
authors.forename: Young-Chang
authors.initials: YC
authors.lastname: Nho
mesh_terms: D000180:Acrylic Resins / Q000494:pharmacology*; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004583:Electrons; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D000080385:Nanogels; D010316:Particle Size; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011094:Polyethyleneimine / Q000494:pharmacology*; D012834:Silver / Q000494:pharmacology*; D013052:Spectrometry, X-Ray Emission; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D055672:Static Electricity; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000180:Acrylic Resins; D000890:Anti-Infective Agents; D000080385:Nanogels; C413692:polyethylene glycol polyethyleneimine nanogel; D012834:Silver; D011092:Polyethylene Glycols; C006903:carbopol 940; D011094:Polyethyleneimine