title: Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica.
abstract: In a continuing search for bioactive constituents from Dioscoreaceae medicinal plants, two new cyclic diarylheptanoids, diosniponol A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of Dioscorea nipponica. The structures of these new compounds were determined by spectroscopic analyses, including extensive two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and optical rotation. All isolated compounds 1-12 were evaluated for their effects on nitric oxide (NO) production in murine microglia cell line BV-2. Compounds 8 and 11 showed potent inhibitory activities on NO production (IC50 13.36 and 14.36 μM, respectively) without cell toxicity in lipopolysaccharide-activated BV-2 cells.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Suwon, Gyeonggi-do 440-746, Republic of Korea.
authors.forename: Kyeong Wan
authors.initials: KW
authors.lastname: Woo
authors.forename: Eunjung
authors.initials: E
authors.lastname: Moon
authors.forename: Oh Wook
authors.initials: OW
authors.lastname: Kwon
authors.forename: Sung Ok
authors.initials: SO
authors.lastname: Lee
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.forename: Sang Zin
authors.initials: SZ
authors.lastname: Choi
authors.forename: Mi Won
authors.initials: MW
authors.lastname: Son
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D036381:Diarylheptanoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D027742:Dioscorea / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D027343:Rhizome / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D036381:Diarylheptanoids; D009569:Nitric Oxide