title: Aspirin resistance in patients undergoing hemodialysis and effect of hemodialysis on aspirin resistance.
abstract: The aim of this study was to evaluate the prevalence of aspirin resistance (AR) in patients undergoing hemodialysis (HD) and to assess the effect of HD on the results of the Multiplate test. A total of 54 patients undergoing HD were included in this study. Blood samples were taken just before and after the HD session. To determine AR, we used Multiplate test. Platelet aggregation values of the study population were 363.01 ± 225.69 aggregation unit (AU) × minutes before and 375.33 ± 254.05 AU × minutes after the HD (P = .597). There was strong correlation between the values before and after HD (R = .755, P < .0001). The AR status was changed in 9 (16.6%) patients after HD. Agreement of AR status before and after HD was substantial (κ coefficient = .667, P < .0001). The prevalence of AR in patients undergoing HD seems higher than in most of the studied populations, and this study has shown that the AR statuses of a significant number of patients undergoing HD change after an HD session.
authors.affiliation: Cardiology Department, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey drhaleunalaksu@gmail.com.
authors.forename: Hale Unal
authors.initials: HU
authors.lastname: Aksu
authors.affiliation: Cardiology Department, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Oner
authors.affiliation: Cardiology Department, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Celik
authors.affiliation: Biochemistry Department, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Nilgun
authors.initials: N
authors.lastname: Isiksacan
authors.affiliation: Cardiology Department, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Aksu
authors.affiliation: Nephrology Department, Haseki Training and Research Hospital, Istanbul, Turkey.
authors.forename: Sami
authors.initials: S
authors.lastname: Uzun
authors.affiliation: Internal Medicine Department, Taksim Training and Research Hospital, Istanbul, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Yavuz
authors.affiliation: Nephrology Department, Haseki Training and Research Hospital, Istanbul, Turkey.
authors.forename: Savas
authors.initials: S
authors.lastname: Ozturk
authors.affiliation: Cardiology Department, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gul
authors.affiliation: Cardiology Department, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Nevzat
authors.initials: N
authors.lastname: Uslu
mesh_terms: D000328:Adult; D000368:Aged; D001241:Aspirin / Q000009:adverse effects*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D010979:Platelet Function Tests; D006435:Renal Dialysis / Q000009:adverse effects*
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin
keywords: Multiplate test; aspirin resistance; hemodialysis