title: A novel method for the preparation of 4-arylimidazolones.
abstract: A series of 4-arylimidazolones have been accessed via late-stage, palladium-mediated arylation of acetone- and cyclohexanone-derived 4-chloroimidazolones. The 4-chloroimidazolones were prepared via a novel rearrangement of the corresponding imidazolone N-oxides. This communication serves as an expansion of chemistry originally developed for our glucagon receptor antagonist program.
authors.affiliation: Discovery and Preclinical Sciences, Merck Research Laboratories, 2015 Galloping Hill Road, K15-2-A218, Kenilworth, New Jersey 07033, USA. duane.demong@merck.com
authors.forename: Duane E
authors.initials: DE
authors.lastname: DeMong
authors.forename: Irene
authors.initials: I
authors.lastname: Ng
authors.forename: Michael W
authors.initials: MW
authors.lastname: Miller
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Stamford
mesh_terms: D002384:Catalysis; D003497:Cyclic N-Oxides / Q000138:chemical synthesis* / Q000737:chemistry*; D003512:Cyclohexanones / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D018027:Receptors, Glucagon / Q000037:antagonists & inhibitors* / Q000737:chemistry*
chemical_list: D003497:Cyclic N-Oxides; D003512:Cyclohexanones; D007093:Imidazoles; D018027:Receptors, Glucagon; C117197:imidazolone; C036468:cyclohexanone; D010165:Palladium