title: Genetic association of sirtuin genes and Parkinson's disease.
abstract: Parkinson's disease (PD) is a neurodegenerative disease caused by both genetic and environmental factors. Sirtuins are highly-conserved, NAD-dependent class III deacetylases that regulate a variety of cellular functions. Most of the known sirtuins have been involved in animal models of neurodegenerative disorders, such as PD. Although seven sirtuin family members have been identified (SIRT1-SIRT7) the relationship between sirtuins and PD in humans has not been established. Our aim was to investigate the association between sirtuin genes and risk of PD. We included 326 PD patients and 371 controls from southern Spain. Forty-one single nucleotide polymorphisms (SNPs) in sirtuin genes were genotyped in order to determine whether they were related to the risk of PD. These SNPs included Tag-SNPs, coding non-synonymous SNPs and SNPs affecting activity of microRNA binding sites. No relationship was found between these SNPs in sirtuin genes and PD. Our data indicate that variations in sirtuin genes do not affect the risk for PD, at least in our population.
authors.affiliation: Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla/Instituto de Biomedicina de Sevilla, Av. Manuel Siurot s/n, 41013 Seville, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Jesús
authors.forename: Pilar
authors.initials: P
authors.lastname: Gómez-Garre
authors.forename: Fátima
authors.initials: F
authors.lastname: Carrillo
authors.forename: María T
authors.initials: MT
authors.lastname: Cáceres-Redondo
authors.forename: Ismael
authors.initials: I
authors.lastname: Huertas-Fernández
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Bernal-Bernal
authors.forename: Marta
authors.initials: M
authors.lastname: Bonilla-Toribio
authors.forename: Laura
authors.initials: L
authors.lastname: Vargas-González
authors.forename: Manuel
authors.initials: M
authors.lastname: Carballo
authors.forename: Pablo
authors.initials: P
authors.lastname: Mir
mesh_terms: D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D037761:Sirtuins / Q000235:genetics*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D037761:Sirtuins