title: [Gestational pemphigoid].
abstract: Gestational pemphigoid is a rare pruritic bullous pregnancy associated dermatosis caused by autoantibodies against placental and dermal collagen XVII. Clinically, it is characterized by severe pruritus and blisters on abdominal skin and extremities. Immunofluorescence analysis of perilesional skin is used in the diagnostics and maternal serum BP180-levels reflect the disease activity. Topical steroids and antihistamins usually relieve mild symptoms, but in severe cases oral corticosteroid is the drug-of-choice. Spontaneous recovery is common after parturition but this disease typically recurs in the following pregnancies. Due to the associated risk of prematurity and fetal growth restriction, prenatal monitoring jointly by a dermatologist and an obstetrician is recommended.
authors.affiliation: OYS, medisiininen tulosalue, ihotautien klinikka ja Oulun yliopisto, ihotautien klinikka, kliinisen lääketieteen laitos.
authors.forename: Laura
authors.initials: L
authors.lastname: Huilaja
authors.forename: Kaarin
authors.initials: K
authors.lastname: Mäkikallio
authors.forename: Kaisa
authors.initials: K
authors.lastname: Tasanen
mesh_terms: D005260:Female; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D008991:Monitoring, Physiologic; D006559:Pemphigoid Gestationis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D011247:Pregnancy; D012008:Recurrence; D012075:Remission, Spontaneous; D012307:Risk Factors; D013256:Steroids / Q000627:therapeutic use
chemical_list: D006633:Histamine Antagonists; D013256:Steroids