title: Non-invasive synergistic treatment of brain tumors by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide.
abstract: The combination of chemo-thermal therapy is the best strategy to ablate tumors, but how to heat deep tumor tissues effectively without side-damage is a challenge. Here, a systemically delivered nanocarrier is designed with multiple advantages, including superior heat absorption, highly efficient hyperthermia, high drug capacity, specific targeting ability, and molecular imaging, to achieve both high antitumor efficacy and effective amplification of hyperthermia with minimal side effects.
authors.affiliation: Department of Chemical and Materials Engineering, Chang Gung University, Kuei-Shan, Tao-Yuan 33302, Taiwan, ROC.
authors.forename: Hung-Wei
authors.initials: HW
authors.lastname: Yang
authors.forename: Mu-Yi
authors.initials: MY
authors.lastname: Hua
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Kun-Ju
authors.initials: KJ
authors.lastname: Lin
authors.forename: Chiung-Yin
authors.initials: CY
authors.lastname: Huang
authors.forename: Rung-Ywan
authors.initials: RY
authors.lastname: Tsai
authors.forename: Chen-Chi M
authors.initials: CC
authors.lastname: Ma
authors.forename: Po-Hung
authors.initials: PH
authors.lastname: Hsu
authors.forename: Shiaw-Pyng
authors.initials: SP
authors.lastname: Wey
authors.forename: Peng-Wei
authors.initials: PW
authors.lastname: Hsu
authors.forename: Pin-Yuan
authors.initials: PY
authors.lastname: Chen
authors.forename: Yin-Cheng
authors.initials: YC
authors.lastname: Huang
authors.forename: Yu-Jen
authors.initials: YJ
authors.lastname: Lu
authors.forename: Tzu-Chen
authors.initials: TC
authors.lastname: Yen
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Feng
authors.forename: Chih-Wen
authors.initials: CW
authors.lastname: Lin
authors.forename: Hao-Li
authors.initials: HL
authors.lastname: Liu
authors.forename: Kuo-Chen
authors.initials: KC
authors.lastname: Wei
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D004337:Drug Carriers / Q000737:chemistry / Q000627:therapeutic use; D006108:Graphite / Q000737:chemistry*; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D008279:Magnetic Resonance Imaging; D059346:Magnets / Q000737:chemistry*; D051379:Mice; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use*; D010087:Oxides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D010087:Oxides; D011092:Polyethylene Glycols; D006108:Graphite
keywords: MRI; brain tumors; focused ultrasound; magnetic nanographene oxide; targeted chemo-thermal therapy