title: Facile synthesis of isochromanones and isoquinolones by AuCl3 catalyzed cascade triggered by an internal nucleophile.
abstract: Synthesis of isochromanones and isoquinolones comprising a quaternary center with high diastereoselectivity was realized via a AuCl3 catalyzed tandem intramolecular exo-dig heterocyclization/enol isomerization/Claisen rearrangement sequence in excellent yields. The reaction is general and amenable for the synthesis of structurally diverse analogues.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India. prasad@orgchem.iisc.ernet.in
authors.forename: Kavirayani R
authors.initials: KR
authors.lastname: Prasad
authors.forename: Chinta
authors.initials: C
authors.lastname: Nagaraju