title: Psychosocial functioning in adolescents with perinatal HIV infection receiving highly active antiretroviral therapy.
abstract: BACKGROUND
  With effective highly active antiretroviral therapy (HAART), perinatally HIV-infected children are living longer through adolescence.
  
  
  METHODS
  We conducted a cross-sectional study of perinatally HIV-infected adolescents, aged 11 to 18 years. Demographically matched controls were also enrolled. The adolescents completed the Youth Self-Report (YSR), while the caregivers filled out the Child Behavior Checklist (CBCL), to determine emotional and behavioral problems.
  
  
  RESULTS
  The sample included 50 HIV-infected adolescents and 56 controls. The internalizing problem scores from the YSR were significantly higher in the HIV-infected group than those in the control group (13.76 versus 9.95, P = .02). The total competence scores, from both the self-report and the caregiver report in the HIV-infected group, were significantly lower than those of the control group (P = .005 and .001).
  
  
  CONCLUSIONS
  Although HAART has prolonged the survival of HIV-infected children, they remain at increased risk of psychosocial problems as well as impaired social functioning.
authors.affiliation: Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Orawan
authors.initials: O
authors.lastname: Louthrenoo
authors.forename: Peninnah
authors.initials: P
authors.lastname: Oberdorfer
authors.forename: Virat
authors.initials: V
authors.lastname: Sirisanthana
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology*; D000374:Aggression; D023241:Antiretroviral Therapy, Highly Active; D001007:Anxiety / Q000523:psychology; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D003863:Depression / Q000523:psychology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000523:psychology* / Q000635:transmission; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D012919:Social Behavior; D011795:Surveys and Questionnaires
keywords: HIV infection; adolescents; antiretroviral; psychosocial