title: Nanoparticle-based systems for T(1)-weighted magnetic resonance imaging contrast agents.
abstract: Because magnetic resonance imaging (MRI) contrast agents play a vital role in diagnosing diseases, demand for new MRI contrast agents, with an enhanced sensitivity and advanced functionalities, is very high. During the past decade, various inorganic nanoparticles have been used as MRI contrast agents due to their unique properties, such as large surface area, easy surface functionalization, excellent contrasting effect, and other size-dependent properties. This review provides an overview of recent progress in the development of nanoparticle-based T1-weighted MRI contrast agents. The chemical synthesis of the nanoparticle-based contrast agents and their potential applications were discussed and summarized. In addition, the recent development in nanoparticle-based multimodal contrast agents including T1-weighted MRI/computed X-ray tomography (CT) and T1-weighted MRI/optical were also described, since nanoparticles may curtail the shortcomings of single mode contrast agents in diagnostic and clinical settings by synergistically incorporating functionality.
authors.affiliation: Department of Medicinal Chemistry and Pharmaceutical Analysis, Guangdong Medical College, Dongwan 523770, Guangdong, China. malina@ciac.jl.cn.
authors.forename: Derong
authors.initials: D
authors.lastname: Zhu
authors.forename: Fuyao
authors.initials: F
authors.lastname: Liu
authors.forename: Lina
authors.initials: L
authors.lastname: Ma
authors.forename: Dianjun
authors.initials: D
authors.lastname: Liu
authors.forename: Zhenxin
authors.initials: Z
authors.lastname: Wang
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D019786:Gadolinium DTPA / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D017895:Manganese Compounds / Q000737:chemistry; D064847:Multimodal Imaging / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media; D017895:Manganese Compounds; D019786:Gadolinium DTPA