title: Expanding the morphologic spectrum of adult biphasic renal tumors--mixed epithelial and stromal tumor of the kidney with focal papillary renal cell carcinoma: case report and review of the literature.
abstract: Mixed epithelial and stromal tumor (MEST) is a distinctive adult biphasic neoplasm of the kidney characterized by the presence of solid and cystic areas composed of spindled stroma and epithelium lining tubules and cystic spaces respectively. Most MESTs are benign although sarcomatous transformation has rarely been reported. It has not been clearly established whether the epithelial component represents entrapped tubules or constitutes a true neoplastic component. We report an unusual case of a biphasic tumor of the kidney with a benign stroma and a focal component of papillary carcinoma arising in one of the cysts and discuss its pathogenesis.
authors.affiliation: 1Department of Pathology, Loyola University Chicago, Maywood, IL, USA.
authors.forename: Kumaran M
authors.initials: KM
authors.lastname: Mudaliar
authors.forename: Vikas
authors.initials: V
authors.lastname: Mehta
authors.forename: Gopal N
authors.initials: GN
authors.lastname: Gupta
authors.forename: Maria M
authors.initials: MM
authors.lastname: Picken
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002291:Carcinoma, Papillary / Q000473:pathology*; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D018193:Neoplasms, Complex and Mixed / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
keywords: biphasic tumors; kidney; mixed epithelial and stromal tumor; papillary renal cell carcinoma