title: Involvement of microglial CD40 in murine retrovirus-induced peripheral neuropathy.
abstract: B6 mice infected with LP-BM5 develop severe immunodeficiency (termed murine acquired immunodeficiency syndrome (MAIDS)) and peripheral neuropathy. To determine whether microglial CD40 is involved in LP-BM5-induced peripheral neuropathy, B6-CD40 knockout (KO) mice and B6-CD40 KO mice adoptively transferred either total leukocytes or B cells were examined for behavioral sensitivity, tissue viral loads, cytokine responses, and the development of MAIDS. All three CD40 KO groups developed MAIDS, the severity of which was correlated with peripheral cytokine responses. CD40 KO mice displayed significantly reduced mechanical hypersensitivity post-infection compared to wild-type mice regardless of cell transfer. These findings support microglial CD40 involvement in LP-BM5-induced peripheral neuropathy.
authors.affiliation: Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, 11 Hills Beach Road, Biddeford, ME 04005, USA. lcao@UNE.edu
authors.forename: Ling
authors.initials: L
authors.lastname: Cao
authors.forename: M Brady
authors.initials: MB
authors.lastname: Butler
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000821:virology; D019013:CD40 Antigens / Q000172:deficiency / Q000276:immunology*; D009052:Leukemia Virus, Murine / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology / Q000473:pathology / Q000821:virology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017628:Microglia / Q000276:immunology* / Q000473:pathology / Q000821:virology; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology / Q000821:virology; D010523:Peripheral Nervous System Diseases / Q000276:immunology / Q000378:metabolism* / Q000821:virology; D011897:Random Allocation; D012190:Retroviridae / Q000276:immunology*
chemical_list: D019013:CD40 Antigens
keywords: CD40; Cytokine; LP-BM5; Murine AIDS; Peripheral neuropathy