title: Successful management of hypoparathyroidism following total thyroidectomy with vitamin D(3) alone.
abstract: OBJECTIVE
  To assess the efficacy and safety of a single administration of vitamin D3 for postoperative hypoparathyroidism.
  
  
  METHODS
  Twelve patients with postoperative hypoparathyroidism were enrolled for this study. They had taken calcium and vitamin D3 orally after the surgery and had shown no symptoms of hypoparathyroidism. Then, all patients had changed their regimen to a single administration of vitamin D3 (1α(OH)D3) with monitoring of serum calcium, urine calcium (u-Ca) and creatinine (u-Cre). The dose of vitamin D3 was started at 2.0μg/day and appropriately adjusted to maintain the ratio of u-Ca and u-Cre (u-Ca/u-Cre) at less than 0.3. The physical findings were carefully checked and the serum intact-parathyroid was also estimated. Those data and physical findings were monitored for at least two years.
  
  
  RESULTS
  The maintenance dose of vitamin D3 varied from 0.5 to 3.5μg/day, and the mean dose was 2.04μg/day. All patients tolerated changes of regimen without any symptoms of hyper-/hypocalcemia.
  
  
  CONCLUSIONS
  A single administration of vitamin D3 is not only safe but also an easy and cost-effective regimen. This also makes drug control easy and worthwhile both for patients and clinicians.
  
  
  METHODS
  2c.
authors.affiliation: Department of Head and Neck surgery, Gunma Prefectural Cancer Center, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Department of Otolaryngology, School of Medicine, Tokyo Medical and Dental University, Japan. Electronic address: atsunoda@mac.com.
authors.forename: Atsunobu
authors.initials: A
authors.lastname: Tsunoda
authors.affiliation: Department of Head and Neck surgery, Gunma Prefectural Cancer Center, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kudo
authors.affiliation: Department of Head and Neck surgery, Gunma Prefectural Cancer Center, Japan.
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Okada
authors.affiliation: Department of Otolaryngology, Head and Neck surgery, School of Medicine, Gunma University, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Toyoda
mesh_terms: D000328:Adult; D000368:Aged; D002762:Cholecalciferol / Q000627:therapeutic use*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000188:drug therapy* / Q000209:etiology; D007012:Hypopharyngeal Neoplasms / Q000601:surgery; D007822:Laryngeal Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016105:Parathyroidectomy / Q000009:adverse effects; D011446:Prospective Studies; D013964:Thyroid Neoplasms / Q000601:surgery; D013965:Thyroidectomy / Q000009:adverse effects; D016896:Treatment Outcome; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D014815:Vitamins; D002762:Cholecalciferol
keywords: Calcium; Medication; Postoperative hypoparathyroidism; Vitamin D(3)