title: High-dose methylprednisolone-induced hepatitis in a patient with multiple sclerosis: a case report and brief review of literature.
abstract: Toxic hepatitis is a rare but serious complication of high-dose prednisolone treatment. We report a case of high-dose prednisolone-induced acute hepatitis in a 48-year-old woman suffering from multiple sclerosis that recurred after repeated administration. Timely recognition is paramount to avoid this complication. This report includes a brief review of the literature on methylprednisolone- induced hepatitis.
authors.affiliation: Department of Gastroenterology and Hepatology, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands. h.dagnolo@mdl.umcn.nl
authors.forename: H M A
authors.initials: HM
authors.lastname: D'Agnolo
authors.forename: J P H
authors.initials: JP
authors.lastname: Drenth
mesh_terms: D000208:Acute Disease; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007275:Injections, Intravenous; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone