title: HMGB1 recruits myeloid derived suppressor cells to promote peritoneal dissemination of colon cancer after resection.
abstract: Peritoneal metastasis of colorectal cancer is a major clinical issue and results in poor prognosis for patients after surgical resection. Here, we found that abdominal surgery trauma induced high release of high-mobility group box 1 (HMGB1) in the peritoneal cavity of mice. Recombinant HMGB1 injected in the peritoneal cavity recruited abundant myeloid derived suppressor cells (MDSCs) after the surgical trauma. HMGB1 Box-A and gemcitabine reduced the recruitment of MDSCs in the peritoneal cavity after the operation and ameliorated the peritoneal metastasis burden of colon cancer in mouse model. These results showed that abdominal surgery trauma leads to a large amount of HMGB1 released in the peritoneal cavity which recruits numerous MDSCs to promote peritoneal metastasis of colon cancer after curative surgery.
authors.affiliation: Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Ke
authors.initials: K
authors.lastname: Wu
authors.forename: Ende
authors.initials: E
authors.lastname: Zhao
authors.forename: Liang
authors.initials: L
authors.lastname: Shi
authors.forename: Ruidong
authors.initials: R
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Yuping
authors.initials: Y
authors.lastname: Yin
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Shuai
authors.forename: Guobin
authors.initials: G
authors.lastname: Wang
authors.forename: Kaixiong
authors.initials: K
authors.lastname: Tao
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D001202:Ascitic Fluid / Q000378:metabolism; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D024243:HMGB1 Protein / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D022423:Myeloid Cells / Q000187:drug effects / Q000378:metabolism*; D010534:Peritoneal Neoplasms / Q000378:metabolism* / Q000556:secondary; D011994:Recombinant Proteins / Q000494:pharmacology; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D024243:HMGB1 Protein; D011994:Recombinant Proteins; D003841:Deoxycytidine; D000093542:Gemcitabine