title: The genetic variant on chromosome 10p14 is associated with risk of colorectal cancer: results from a case-control study and a meta-analysis.
abstract: BACKGROUND
  A common single nucleotide polymorphism (SNP), rs10795668, located at 10p14, was first identified to be significantly associated with risk of colorectal cancer (CRC) by a genome-wide association study (GWAS) in 2008; however, another GWAS and following replication studies yielded conflicting results.
  
  
  METHODS
  We conducted a case-control study of 470 cases and 475 controls in a Chinese population and then performed a meta-analysis, integrating the current study and 9 publications to evaluate the association between rs10795668 and CRC risk. Heterogeneity among studies and publication bias were assessed by the χ²-based Q statistic test and Egger's test, respectively.
  
  
  RESULTS
  In the case-control study, significant association between the SNP and CRC risk was observed, with per-A-allele OR of 0.71 (95%CI: 0.54-0.94, P = 0.017). The following meta-analysis further confirmed the significant association, with per-A-allele OR of 0.91 (95%CI: 0.89-0.93, P(heterogeneity) >0.05) in European population and 0.86 (95%CI: 0.78-0.96, P(heterogeneity) <0.05) in Asian population. Besides, sensitivity analyses and publication bias assessment indicated the robust stability and reliability of the results.
  
  
  CONCLUSIONS
  Results from our case-control study and the followed meta-analysis confirmed the significant association of rs10795668 with CRC risk.
authors.affiliation: Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Qin
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Rong
authors.initials: R
authors.lastname: Zhong
authors.forename: Li
authors.initials: L
authors.lastname: Zou
authors.forename: Jieyun
authors.initials: J
authors.lastname: Yin
authors.forename: Beibei
authors.initials: B
authors.lastname: Zhu
authors.forename: Beibei
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authors.lastname: Cao
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Jigui
authors.initials: J
authors.lastname: Chen
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Li
authors.forename: Tingting
authors.initials: T
authors.lastname: Li
authors.forename: Xuzai
authors.initials: X
authors.lastname: Lu
authors.forename: Jiao
authors.initials: J
authors.lastname: Lou
authors.forename: Juntao
authors.initials: J
authors.lastname: Ke
authors.forename: Sheng
authors.initials: S
authors.lastname: Wei
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Miao
authors.forename: Shaofa
authors.initials: S
authors.lastname: Nie
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002681:China; D002879:Chromosomes, Human, Pair 10; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide