title: Novel antibodies targeting immune regulatory checkpoints for cancer therapy.
abstract: Cancers must evade or suppress the immune system in order to develop. Better understanding of the molecular regulation governing tumour detection and effective activation of the immune system (so called immune regulatory checkpoints) has provided new targets for cancer immunotherapy. Therapeutic monoclonal antibodies against these targets are currently undergoing clinical evaluation with more in pre-clinical development; buoyed by the recent licence approval of the anti-CTLA-4 antibody, ipilumumab, for use in melanoma. This article will review the current status of the various antibodies and target molecules being investigated.
authors.affiliation: Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.
authors.forename: Chern Siang
authors.initials: CS
authors.lastname: Lee
authors.forename: Mark
authors.initials: M
authors.lastname: Cragg
authors.forename: Martin
authors.initials: M
authors.lastname: Glennie
authors.forename: Peter
authors.initials: P
authors.lastname: Johnson
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000951:Antigens, Neoplasm / Q000276:immunology*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D059447:Cell Cycle Checkpoints / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents
keywords: cancer; immunomodulatory antibodies; immunotherapy; monoclonal antibodies