title: Commercially bioavailable proprietary technologies and their marketed products.
abstract: In this review, we discuss the methodologies and platform technologies for enhancing the oral bioavailability of poorly soluble drugs. We also highlight the mechanisms of formulation technologies for improving desired physicochemical attributes of active substances. We focus on various commercial technologies, along with marketed products, and identify proprietary technologies protected by patents. We also discuss nonpropriety technologies, such as mesoporous silica, cyclodextrin complexation and solid dispersions. In addition, we highlight the factors affecting drug absorption and/or bioavailability, the methodologies available to prepare bioavailability-enhanced products, stability issues and examples of technology implementation.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia. Electronic address: afealam@rediffmail.com.
authors.forename: Mohd Aftab
authors.initials: MA
authors.lastname: Alam
authors.forename: Fahad I
authors.initials: FI
authors.lastname: Al-Jenoobi
authors.forename: Abdullah M
authors.initials: AM
authors.lastname: Al-Mohizea
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004337:Drug Carriers / Q000737:chemistry / Q000191:economics / Q000493:pharmacokinetics*; D006801:Humans; D040541:Marketing / Q000191:economics / Q000639:trends*; D053758:Nanoparticles / Q000737:chemistry / Q000191:economics / Q000378:metabolism; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000191:economics / Q000639:trends*
chemical_list: D004337:Drug Carriers