title: The relationship between tumour necrosis factor-α gene polymorphism and susceptibility and clearance of the persistent hepatitis B virus infection in a Chinese population: a meta-analysis.
abstract: To date, many studies conducted in the Chinese population have determined the correlation between the tumour necrosis factor-α (TNF-α)-238G/A, -308G/A, -857C/T and -863C/A polymorphisms and persistent hepatitis B virus (HBV) infection. However, their results remain inconclusive. With the aim of confirming this correlation, we performed a meta-analysis of 19 studies. The dichotomous data are presented as the OR with a 95% CI. The results of our study indicate that carriers of the TNF-α-857T allele among the pooled Chinese population were more likely to show spontaneous clearance of HBV (T vs C: OR = 0.824, 95% CI = 0.713-0.953, p 0.009; TT vs CC: OR = 0.701, 95% CI = 0.507-0.970, p 0.032; TC vs CC: OR = 0.804, 95% CI = 0.683-0.947, p 0.009; TT + TC vs CC: OR = 0.835, 95% CI = 0.716-0.974, p 0.021). The TNF-α-308A allele was associated with significantly reduced persistent HBV infection risk in the Chinese (A vs G: OR = 0.585, 95% CI = 0.456-0.751, p 0.002; AG vs GG: OR = 0.519, 95% CI = 0.341-0.789, p <0.000; AA + AG vs GG: OR = 0.512, 95% CI = 0.339-0.772, p 0.001). Persistent HBV infection susceptibility is associated with the TNF-α-308G/A gene polymorphism in the Chinese population, whereas HBV clearance is associated with the TNF-α-857C/T gene polymorphism.
authors.affiliation: Jiangxi Province Centre For Disease Control And Prevention, Nanchang, China.
authors.forename: T-C
authors.initials: TC
authors.lastname: Zhang
authors.forename: Y-Q
authors.initials: YQ
authors.lastname: Zhao
authors.forename: G-L
authors.initials: GL
authors.lastname: Hu
authors.forename: X-Q
authors.initials: XQ
authors.lastname: Liu
authors.forename: X-K
authors.initials: XK
authors.lastname: Huang
mesh_terms: D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006509:Hepatitis B / Q000235:genetics* / Q000821:virology*; D006515:Hepatitis B virus; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: Gene polymorphism; hepatitis B virus; meta-analysis; susceptibility; tumour necrosis factor-α gene