title: The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association.
abstract: Systemic administration of S18986, a positive allosteric modulator of AMPA receptors, improves cognition. The present study further characterizes the drug's memory-enhancing properties and is the first to investigate its intracerebral effects on learning and memory. The results showed that rats receiving a single dose of S18986 (3 μg/site) into the prelimbic cortex, prior to olfactory discrimination acquisition, exhibited significantly shorter latencies and fewer errors to make the correct response, both in the acquisition and two drug-free retention tests. Such findings corroborate the involvement of glutamate receptors in odor-reward learning and confirm the role of the AMPAkine S18986 as a cognitive enhancer.
authors.affiliation: Departament de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain. nyefimenko@yahoo.es
authors.forename: Natalya
authors.initials: N
authors.lastname: Yefimenko
authors.forename: Marta
authors.initials: M
authors.lastname: Portero-Tresserra
authors.forename: Margarita
authors.initials: M
authors.lastname: Martí-Nicolovius
authors.forename: Gemma
authors.initials: G
authors.lastname: Guillazo-Blanch
authors.forename: Anna
authors.initials: A
authors.lastname: Vale-Martínez
mesh_terms: D000818:Animals; D001245:Association Learning / Q000187:drug effects / Q000502:physiology*; D001581:Benzothiadiazines / Q000494:pharmacology*; D008297:Male; D011939:Mental Recall / Q000187:drug effects* / Q000502:physiology; D018697:Nootropic Agents / Q000494:pharmacology; D009812:Odorants; D017397:Prefrontal Cortex / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000819:agonists* / Q000378:metabolism; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology*; D012201:Reward; D012903:Smell / Q000187:drug effects / Q000502:physiology
chemical_list: D001581:Benzothiadiazines; D018697:Nootropic Agents; D018091:Receptors, AMPA; C414205:S18986-1
keywords: AMPA receptors; Cognitive enhancer; Glutamate; Memory facilitation; Olfactory discrimination; Prefrontal cortex