title: The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling.
abstract: Immune evasion by rabies virus depends on targeting of the signal transducers and activator of transcription 1 (STAT1) and STAT2 proteins by the viral interferon antagonist P protein, but targeting of other STAT proteins has not been investigated. Here, we find that P protein associates with activated STAT3 and inhibits STAT3 nuclear accumulation and Gp130-dependent signaling. This is the first report of STAT3 targeting by the interferon antagonist of a virus other than a paramyxovirus, indicating that STAT3 antagonism is important to a range of human-pathogenic viruses.
authors.affiliation: Viral Pathogenesis Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia.
authors.forename: Kim G
authors.initials: KG
authors.lastname: Lieu
authors.forename: Aaron
authors.initials: A
authors.lastname: Brice
authors.forename: Linda
authors.initials: L
authors.lastname: Wiltzer
authors.forename: Bevan
authors.initials: B
authors.lastname: Hirst
authors.forename: David A
authors.initials: DA
authors.lastname: Jans
authors.forename: Danielle
authors.initials: D
authors.lastname: Blondel
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Moseley
mesh_terms: D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D050822:Cytokine Receptor gp130 / Q000378:metabolism*; D049452:Green Fluorescent Proteins / Q000378:metabolism; D057131:Immune Evasion / Q000235:genetics*; D007372:Interferons / Q000037:antagonists & inhibitors*; D008156:Luciferases; D008164:Luminescent Proteins / Q000378:metabolism; D018613:Microscopy, Confocal; D018832:Molecular Chaperones; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D011820:Rabies virus / Q000235:genetics* / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*; D015678:Viral Structural Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D000097573:Red Fluorescent Protein
chemical_list: D050822:Cytokine Receptor gp130; D049452:Green Fluorescent Proteins; D007372:Interferons; D008156:Luciferases; D008164:Luminescent Proteins; D018832:Molecular Chaperones; D010750:Phosphoproteins; D050796:STAT3 Transcription Factor; D015678:Viral Structural Proteins; D000097573:Red Fluorescent Protein; C103961:P phosphoprotein, Rabies virus