title: Borneol, a bicyclic monoterpene alcohol, reduces nociceptive behavior and inflammatory response in mice.
abstract: Borneol, a bicyclic monoterpene, has been evaluated for antinociceptive and anti-inflammatory activities. Antinociceptive and anti-inflammatory activities were studied by measuring nociception by acetic acid, formalin, hot plate, and grip strength tests, while inflammation was prompted by carrageenan-induced peritonitis. The rotarod test was used to evaluate motor coordination. Borneol produced a significant (P < 0.01) reduction of the nociceptive behavior at the early and late phases of paw licking and reduced the writhing reflex in mice (formalin and writhing tests, resp.). When the hot plate test was conducted, borneol (in higher dose) produced an inhibition (P < 0.05) of the nociceptive behavior. Such results were unlikely to be provoked by motor abnormality. Additionally, borneol-treated mice reduced the carrageenan-induced leukocytes migration to the peritoneal cavity. Together, our results suggest that borneol possess significant central and peripheral antinociceptive activity; it has also anti-inflammatory activity. In addition, borneol did not impair motor coordination.
authors.affiliation: Núcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil. jackson.guedes@univasf.edu.br
authors.forename: Jackson Roberto Guedes da Silva
authors.initials: JR
authors.lastname: Almeida
authors.forename: Grasielly Rocha
authors.initials: GR
authors.lastname: Souza
authors.forename: Juliane Cabral
authors.initials: JC
authors.lastname: Silva
authors.forename: Sarah Raquel Gomes de Lima
authors.initials: SR
authors.lastname: Saraiva
authors.forename: Raimundo Gonçalves de Oliveira
authors.initials: RG
authors.lastname: Júnior
authors.forename: Jullyana de Souza Siqueira
authors.initials: Jde S
authors.lastname: Quintans
authors.forename: Rosana de Souza Siqueira
authors.initials: Rde S
authors.lastname: Barreto
authors.forename: Leonardo Rigoldi
authors.initials: LR
authors.lastname: Bonjardim
authors.forename: Sócrates Cabral de Holanda
authors.initials: SC
authors.lastname: Cavalcanti
authors.forename: Lucindo José
authors.initials: LJ
authors.lastname: Quintans
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001892:Camphanes / Q000008:administration & dosage*; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D058748:Pain Perception / Q000187:drug effects*; D017288:Pain Threshold / Q000187:drug effects*; D010538:Peritonitis / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D001892:Camphanes; D002351:Carrageenan; C022871:isoborneol