title: Can transient elastography be a reliable method for assessing liver fibrosis in non alcoholic steatohepatitis (NASH)?
abstract: The aim of our study was to evaluate the severity of liver damage in non-alcoholic steatohepatitis (NASH) patients, by means of Transient Elastography (TE), using prespecified cut-off values of liver stiffness (LS) measurements.
  
  
  METHODS
  Our retrospective study included 478 NASH patients. Ten LS measurements were performed in each patient by means of TE, by using a standard M-probe. A median value expressed in kilopascals (kPa) was calculated. Reliable measurements were defined as: median value of 10 LS measurements with a success rate (SR) >/= 60% and an interquartile range (IQR) <30%. Patients were divided into 3 categories using prespecified TE cut-offs for LS: <7.9kPa (absence of severe fibrosis); values ranging between 7.9 kPa and 9.6 kPa ("gray zone" in which biopsy is recommended); and > 9.6kPa (severe fibrosis).
  
  
  RESULTS
  Reliable measurements were obtained in 81.6% of NASH patients. Female gender, older age and higher BMI were associated with an impossibility to obtain reliable TE measurements. Three hundred and ninety patients with reliable LS measurements were included in the final analysis. Of those, 70.8% had no severe fibrosis, 10.8% were in the "gray zone" in which biopsy is recommended and 18.5% had severe fibrosis.
  
  
  CONCLUSIONS
  In 81.6% of our NASH patients we were able to obtain reliable LS measurements by means of TE, using a standard M-probe. In our study, approximately 30% of NASH patients had LS measurements compatible with severe fibrosis and should be evaluated for urgent measures to prevent disease progression.
authors.affiliation: Department of Gastroenterology and Hepatology, "Victor Babes" University of Medicine and Pharmacy, Timişoara, Romania. isporea@umft.ro
authors.forename: Ioan
authors.initials: I
authors.lastname: Sporea
authors.forename: Ana
authors.initials: A
authors.lastname: Jurchiş
authors.forename: Roxana
authors.initials: R
authors.lastname: Şirli
authors.forename: Simona
authors.initials: S
authors.lastname: Bota
authors.forename: Mădălina
authors.initials: M
authors.lastname: Sendroiu
mesh_terms: D015984:Causality; D054459:Elasticity Imaging Techniques / Q000706:statistics & numerical data*; D005234:Fatty Liver / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D012680:Sensitivity and Specificity