title: Oxidative stress parameters and ceruloplasmin levels in patients with severe preeclampsia.
abstract: BACKGROUND
  Oxidative stress is believed to have a role in the development of preeclampsia (PE). It is known that an increased ceruloplasmin (CP) level is also associated with PE. The aim of this study was to investigate the relationship between oxidative stress parameters and CP levels in patients with severe PE.
  
  
  METHODS
  Sixty patients with severe PE and 60 healthy pregnant women were recruited to the study. All study subjects were divided into 2 groups; group 1(n=60) consisted of patients with severe PE, and group 2 (n=60) consisted of healthy pregnant subjects. Blood samples were obtained to measure CP, total antioxidant status and total oxidant status from all subjects. Oxidative stress index was calculated.
  
  
  RESULTS
  Compared to group 2; group 1 had significantly higher CP, total oxidant status, oxidative stress index and lower total antioxidant status levels (p<0.001, p<0.001, p=0.001, p=0.008, respectively). Serum CP levels were significantly correlated with oxidative stress index levels (r=0.385, p=0.002).
  
  
  CONCLUSIONS
  The present study demonstrated that both oxidative stress and CP levels increased in patients with PE, and increased CP levels seem to be a consequence of oxidative stress.
authors.affiliation: Department of Internal Medicine, Harran University, Sanlıurfa, Turkey.
authors.forename: M E
authors.initials: ME
authors.lastname: Demir
authors.forename: T
authors.initials: T
authors.lastname: Ulas
authors.forename: M S
authors.initials: MS
authors.lastname: Dal
authors.forename: M A
authors.initials: MA
authors.lastname: Eren
authors.forename: H
authors.initials: H
authors.lastname: Aydogan
authors.forename: S
authors.initials: S
authors.lastname: Yalcin
authors.forename: A
authors.initials: A
authors.lastname: Camuzcuoglu
authors.forename: N G
authors.initials: NG
authors.lastname: Hilali
authors.forename: N
authors.initials: N
authors.lastname: Aksoy
authors.forename: H
authors.initials: H
authors.lastname: Buyukhatipoglu
mesh_terms: D000328:Adult; D002570:Ceruloplasmin / Q000032:analysis*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood* / Q000378:metabolism*; D011247:Pregnancy; D012720:Severity of Illness Index
chemical_list: D002570:Ceruloplasmin