title: [Parathyroid hormone and Wnt signaling].
abstract: Parathyroid hormone (PTH) is clinically used as therapeutic agent for osteoporosis in Japan. However, the mechanisms for bone anabolic action of PTH are not fully understood. Recently, numerous studies suggest that PTH enhances bone formation through the suppression of sclerostin, DKK1 and sFRP1, inhibitors of Wnt-β-catenin signal. Moreover, we identified Tmem119 as new osteoblast differentiation factor, which is involved in an increase inβ-catenin level by PTH in osteoblasts. Further understanding of Wnt-β-catenin signaling in the bone anabolic action by PTH may lead to the development of novel bone anabolic agent.
authors.affiliation: Department of Physiology and Regenerative Medicine, Kinki University Faculty of Medicine, Japan.
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Tamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kaji
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D006801:Humans; D010006:Osteoblasts / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000502:physiology*; D051176:beta Catenin / Q000378:metabolism
chemical_list: D010281:Parathyroid Hormone; D051153:Wnt Proteins; D051176:beta Catenin