title: [Preparation of panax notoginseng saponins-tanshinone H(A) composite method for pulmonary delivery with spray-drying method and its characterization].
abstract: OBJECTIVE
  To prepare panax notoginseng saponins-tanshinone II(A) composite particles for pulmonary delivery, in order to explore a dry powder particle preparation method ensuring synchronized arrival of multiple components of traditional Chinese medicine compounds at absorption sites.
  
  
  METHODS
  Panax notoginseng saponins-tanshinone II(A) composite particles were prepared with spray-drying method, and characterized by scanning electron microscopy (SEM), confocal laser scanning microscope (CLSM), X-ray diffraction (XRD), infrared analysis (IR), dry laser particle size analysis, high performance liquid chromatography (HPLC) and the aerodynamic behavior was evaluated by a Next Generation Impactor (NGI).
  
  
  RESULTS
  The dry powder particles produced had narrow particle size distribution range and good aerodynamic behavior, and could realize synchronized administration of multiple components.
  
  
  CONCLUSIONS
  The spray-drying method is used to combine traditional Chinese medicine components with different physical and chemical properties in the same particle, and product into traditional Chinese medicine compound particles in line with the requirements for pulmonary delivery.
authors.affiliation: Key Laboratory of Separation Engineering for Traditional Chinese Medicine Compound, Nanjing University of Chinese Medicine, Nanjing 210029, China. wanghm1362@163.com
authors.forename: Hua-Mei
authors.initials: HM
authors.lastname: Wang
authors.forename: Ting-Ming
authors.initials: TM
authors.lastname: Fu
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Guo
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000378:metabolism*; D000042:Absorption; D003890:Desiccation; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D053723:Panax notoginseng / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry*
chemical_list: D045784:Abietanes; D004365:Drugs, Chinese Herbal; D012503:Saponins; C021751:tanshinone