title: Body fat percentage as a marker of new-onset diabetes mellitus after kidney transplantation.
abstract: BACKGROUND
  New-onset diabetes after transplantation (NODAT) is a serious metabolic complication that can follow kidney transplantation. Several risk factors, including obesity, have been related to NODAT development. Obesity is defined as an excessive accumulation of body fat, and body fat percentage (BF%) has been commonly measured by different techniques, including bioelectrical impedance analysis. However, the correlation between an increase in BF% and the development of NODAT during outpatient follow-up has not yet been explored. We aimed to elucidate the association between BF% changes and the development of NODAT.
  
  
  METHODS
  We performed a retrospective study involving 45 patients without diabetes who underwent kidney transplantation in our hospital between March 2008 and December 2010. We compared the BF% and demographic variables of patients who did and did not develop NODAT during follow-up.
  
  
  RESULTS
  Four patients (8.9%) developed NODAT during a mean follow-up period of 30.3 months. The post-transplantation increase in BF% was much higher in NODAT+ patients than the NODAT- patients. Univariate analysis indicated that the rate of increase in BF% was a risk factor for NODAT (hazard ratio [HR], 1.08 [1.02-1.18]; P < .005).
  
  
  CONCLUSIONS
  A large increase in BF% may be a risk factor for NODAT. These findings underline the importance of routine BF% measurements in medical practice.
authors.affiliation: Department of Surgery, Sendai Shakaihoken Hospital, Sendai, Japan. tsu7ka5so8mi@yahoo.co.jp
authors.forename: K
authors.initials: K
authors.lastname: Tokodai
authors.forename: N
authors.initials: N
authors.lastname: Amada
authors.forename: H
authors.initials: H
authors.lastname: Kikuchi
authors.forename: I
authors.initials: I
authors.lastname: Haga
authors.forename: T
authors.initials: T
authors.lastname: Takayama
authors.forename: A
authors.initials: A
authors.lastname: Nakamura
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D001823:Body Composition; D003920:Diabetes Mellitus / Q000209:etiology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D007166:Immunosuppressive Agents