title: Association between Sirtuin 2 gene rs10410544 polymorphism and depression in Alzheimer's disease in two independent European samples.
abstract: Among the several genes associated with late-onset Alzheimer's disease (LOAD), recently, Sirtuin genes have roused a growing interest because of their involvement in metabolic homeostasis and in brain aging. Particularly SIRT2 gene has been associated with Alzheimer's disease (AD) as well as with mood disorders. The aim of this study is to investigate the possible associations between Sirtuin 2 gene (SIRT2) rs10410544 polymorphism and AD as well as depression in AD. In addition, we performed some exploratory analyses to investigate possible associations between the rs10410544 genotype and clinical features. We investigated these associations in two independent samples: the first one was composed of 275 Greek inhabitants and 117 patients; the second sample counted 181 Italian people and 43 patients. All patients were affected by LOAD. We failed to find any association between rs10410544 genotype and AD in the two samples. On the other hand, we found an association between the single nucleotide polymorphism (SNP) and depressive symptomatology (in the total sample p = 0.002), which was modulated by the tumor necrosis factor (TNF) values. Particularly, TT genotype seems to be protective versus depression. Finally, in the exploratory analyses, we found that the TT genotype was associated with earlier AD onset and a longer duration of the illness. In conclusion, we confirmed the association between SIRT2 gene and mood disturbances, although in AD patients. Further, we provided evidence that the TT genotype may be protective versus depressive symptoms, allowing an easier and thus earlier diagnosis of AD. This awareness may lead to a more detailed approach to these patients concerning diagnosis and therapy.
authors.affiliation: Department of Biomedical and NeuroMotor Sciences, University of Bologna, Viale Carlo Pepoli 5, 40123, Bologna, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Porcelli
authors.forename: Raffaele
authors.initials: R
authors.lastname: Salfi
authors.forename: Antonis
authors.initials: A
authors.lastname: Politis
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Atti
authors.forename: Diego
authors.initials: D
authors.lastname: Albani
authors.forename: Armando
authors.initials: A
authors.lastname: Chierchia
authors.forename: Letizia
authors.initials: L
authors.lastname: Polito
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Zisaki
authors.forename: Christina
authors.initials: C
authors.lastname: Piperi
authors.forename: Ioannis
authors.initials: I
authors.lastname: Liappas
authors.forename: Siegfried
authors.initials: S
authors.lastname: Alberti
authors.forename: Martina
authors.initials: M
authors.lastname: Balestri
authors.forename: Agnese
authors.initials: A
authors.lastname: Marsano
authors.forename: Evangelia
authors.initials: E
authors.lastname: Stamouli
authors.forename: Antonis
authors.initials: A
authors.lastname: Mailis
authors.forename: Gloria
authors.initials: G
authors.lastname: Biella
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Forloni
authors.forename: Virginia
authors.initials: V
authors.lastname: Bernabei
authors.forename: Barbara
authors.initials: B
authors.lastname: Ferrari
authors.forename: Loredana
authors.initials: L
authors.lastname: Lia
authors.forename: George N
authors.initials: GN
authors.lastname: Papadimitriou
authors.forename: Diana
authors.initials: D
authors.lastname: De Ronchi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics*; D000704:Analysis of Variance; D003863:Depression / Q000209:etiology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006115:Greece; D006801:Humans; D007558:Italy; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D056565:Sirtuin 2 / Q000235:genetics*
chemical_list: C474199:SIRT2 protein, human; D056565:Sirtuin 2