title: Total synthesis of dictyodendrins B and E.
abstract: The concise synthesis of the novel telomerase inhibitors dictyodendrins B and E was completed in only 9 and 11 steps (longest linear sequence). The highly convergent strategy employed a palladium-catalyzed Larock indole synthesis and a palladium-mediated one-pot consecutive Buchwald-Hartwig amination/C-H activation reaction as key steps. The present synthesis exhibits respectable levels of atom-, redox-, and step-economy.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liang
authors.forename: Weimin
authors.initials: W
authors.lastname: Hu
authors.forename: Pengyu
authors.initials: P
authors.lastname: Tao
authors.forename: Yanxing
authors.initials: Y
authors.lastname: Jia
mesh_terms: D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D019098:Telomerase / Q000037:antagonists & inhibitors
chemical_list: D002227:Carbazoles; D011758:Pyrroles; C505029:dictyodendrin B; C523042:dictyodendrin E; D019098:Telomerase