title: [Low-dose daily de-escalatory administration of tadalafil for psychological erectile dysfunction].
abstract: OBJECTIVE
  To investigate the effect of low-dose daily de-escalatory administration of tadalafil on psychological erectile dysfunction (ED).
  
  
  METHODS
  We randomized 84 psychological ED patients into an observation and a control group of equal number to receive low-dose daily de-escalatory administration and on-demand medication of tadalafil, respectively, both for 2 months. We compared the scores on IIEF-5 and erection hardness (EHS) between the two groups before and after the treatment.
  
  
  RESULTS
  The treatment and follow-up were accomplished for 79 cases, with 5 withdrawals in the control group. The IIEF-5 and EHS scores were remarkably improved in both the observation and control groups after treatment. The rate of therapeutic effectiveness was significantly higher in the observation group than in the control (95.2% vs 86.5%, P < 0.05).
  
  
  CONCLUSIONS
  Low-dose daily de-escalatory administration of tadalafil is highly effective and even better than on-demand medication of tadalafil for psychological ED.
authors.affiliation: Department of Andrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. cunhaohuang@163.com
authors.forename: Cun-Chao
authors.initials: CC
authors.lastname: Huang
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Liang
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Li
authors.forename: Shi-Kun
authors.initials: SK
authors.lastname: Liang
authors.forename: Wei-Ru
authors.initials: WR
authors.lastname: Song
authors.forename: Xun
authors.initials: X
authors.lastname: Zhang
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Wei
authors.forename: Chun-Hui
authors.initials: CH
authors.lastname: Zhu
authors.forename: Ping
authors.initials: P
authors.lastname: Wei
authors.forename: Yun-Bin
authors.initials: YB
authors.lastname: Chen
mesh_terms: D000328:Adult; D002243:Carbolines / Q000008:administration & dosage* / Q000627:therapeutic use; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D000068581:Tadalafil; D055815:Young Adult
chemical_list: D002243:Carbolines; D010726:Phosphodiesterase Inhibitors; D000068581:Tadalafil