title: [Analysis of the use of liposomal amphotericin B].
abstract: BACKGROUND
  The increase in immunosuppressed patients and in the use of cytotoxic and immunosuppressive agents in the last few years has led to a rise in the incidence of invasive fungal infections.
  
  
  OBJECTIVE
  The objective of this study is to evaluate the use of liposomal amphotericin B according to its indication, dosage, effectiveness and nephrotoxicity.
  
  
  METHODS
  This is a retrospective study over a 8 year-period. Indications and dosage described in the Summary of Product Characteristics were taken as reference. Effectiveness was measured in terms of resolution of infection, no recurrence or emergence, survival at 7th day, no discontinuation and no addition of another antifungal. Effectiveness was also analysed in relation to indication, dosage, treatment duration, cumulative dose and comorbidity. Nephrotoxicity was defined as a doubled serum creatinine when compared with basal values.
  
  
  RESULTS
  A total of 47 episodes were analysed, with 91.5% of treatments being adequate for the indications. Effectiveness was achieved in 44.7% of cases: 33% in neutropenic patients, 50% of aspergillosis, 60% of candidiasis, and 100% of the leishmaniasis. Response rates in patients treated for 15 days or less and those for more than 15 days were 25 and 56.5% (P=.039), respectively. The main causes of failure were death (23%) and lack of effectiveness (17%), with 9% of patients suffering from nephrotoxicity.
  
  
  CONCLUSIONS
  The effectiveness and nephrotoxicity data agree with those obtained in other studies. Liposomal amphotericin B is a safe drug with a moderate effectiveness that is associated with the duration of the treatment.
authors.affiliation: Servicio de Farmacia Hospitalaria, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España. Electronic address: mglez4@gmail.com.
authors.forename: María
authors.initials: M
authors.lastname: González Martínez
authors.affiliation: Servicio de Farmacia Hospitalaria, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
authors.forename: Carolina
authors.initials: C
authors.lastname: Mariño Martínez
authors.affiliation: Servicio de Farmacia Hospitalaria, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
authors.forename: Gema
authors.initials: G
authors.lastname: Baldominos Utrilla
authors.affiliation: Área de Farmacología, Departamento de Ciencias Biomédicas, Universidad de León, León, España.
authors.forename: María Nélida
authors.initials: MN
authors.lastname: Fernández Martínez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced; D007896:Leishmaniasis / Q000188:drug therapy; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D009503:Neutropenia / Q000150:complications; D012189:Retrospective Studies; D013030:Spain; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D000981:Antiprotozoal Agents; D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B; D003404:Creatinine
keywords: Anfotericina B liposomal; Drug toxicity; Efectividad; Estudio de utilización; Evaluation study; Liposomal amphotericin B; Toxicidad farmacológica; Treatment effectiveness