title: Engineering polymeric microparticles as theranostic carriers for selective delivery and cancer therapy.
abstract: Multifunctional polymeric nano- and microparticles are engineered as theranostic carriers and their selective size-dependent cellular uptake is demonstrated. It is found that effective uptake and accumulation of nanoparticles occurs in both normal and cancer cells, whereas, that of microparticles occurs in cancer cells but not in normal cells, allowing cancer cells to be specifically targeted for local drug delivery.
authors.affiliation: Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602.
authors.forename: Khin Yin
authors.initials: KY
authors.lastname: Win
authors.forename: Enyi
authors.initials: E
authors.lastname: Ye
authors.forename: Choon Peng
authors.initials: CP
authors.lastname: Teng
authors.forename: Shan
authors.initials: S
authors.lastname: Jiang
authors.forename: Ming-Yong
authors.initials: MY
authors.lastname: Han
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D002166:Camptothecin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D008863:Microspheres; D053758:Nanoparticles / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D045663:Quantum Dots
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D002166:Camptothecin
keywords: cancer therapy; microparticles; nanoparticles; selective uptake