title: Morbidity of solid cancer in Behςet's disease: analysis of 11 cases in a series of 506 patients.
abstract: OBJECTIVE
  Behςet's disease (BD) is rarely reported to be associated with malignancies in the literature. However, the frequency of cancer in BD patients remains unknown. This study evaluated cancer morbidity in BD patients compared with that in the general population of Korea.
  
  
  METHODS
  A retrospective chart review was performed on 506 patients visiting our hospital from 1994 to 2011 for BD. We analyzed the standardized morbidity rate (SMR), which is the ratio of observed to expected malignancies. Furthermore, we reviewed cases of solid cancer in BD patients in the literature.
  
  
  RESULTS
  Of the 506 patients with BD, 11 (2.17%) developed cancer. We found a variety of solid cancers without predominance and no hematologic malignancies. The total number of cancers observed was less than expected, which was determined from the statistical data of the National Cancer Information Center of Korea, with an SMR of 0.023 (95% confidence interval, 0.012-0.039).
  
  
  CONCLUSIONS
  BD may be associated with a lower cancer-related morbidity compared with the general population of Korea.
authors.affiliation: Department of Dermatology, Ajou University School of Medicine, 164 World cup-ro, Yeongtong-gu, Suwon 443-721, Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Na
authors.forename: Jaeyoung
authors.initials: J
authors.lastname: Shin
authors.forename: Eun-So
authors.initials: ES
authors.lastname: Lee
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000601:surgery; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies
keywords: Behςet’s disease; malignancy; morbidity; solid cancer