title: The human genome: its modifications and interactions with those of the microbiome, and the practice of genomic medicine.
abstract: In genomic medicine, the nuclear genome is usually the focus of discussion. However, recent developments in genomics show that our interaction with the biological world at large alters our susceptibility to disease and our response to drugs. For example, in addition to causing infection, the trillions of microbial cells that inhabit our bodies (our microbiome), are now known to shape our immune system and our metabolic health. Moreover, mitochondria, the long-assimilated symbionts, are the focus of considerable current genomic research that is making possible, interventions that were at one time in the realms of science fiction. Furthermore, genomics research of the cancer cell is sufficiently refined to enable us to define its genome as a distinct entity suitable for selective drug-targeting. In this contribution we discuss, within their historical contexts, some of these seemingly disparate scientific strands to highlight the importance of embracing a broader multiple-genomic vista when dealing with disease causation, prevention, and management.
authors.affiliation: National Genetics Education and Development Centre, Birmingham, United Kingdom. a.li-wan-po@talk21.com
authors.forename: Alain
authors.initials: A
authors.lastname: Li-Wan-Po
mesh_terms: D001086:Arabinofuranosyluracil / Q000031:analogs & derivatives / Q000627:therapeutic use; D015894:Genome, Human; D023281:Genomics; D006801:Humans; D054892:Metagenome; D028361:Mitochondrial Diseases / Q000628:therapy
chemical_list: D001086:Arabinofuranosyluracil; C031368:sorivudine