title: Sensitivity and specificity of ultrasound in detecting (osteo)chondral defects: a cadaveric study.
abstract: The long-term prognosis of cartilage lesions evolving into an eroding subchondral bone defect is not known. Longitudinal monitoring using ultrasound could assist in overall understanding. The aim of the work described in this article was to determine the feasibility of using ultrasound to detect small (osteo)chondral defects. On the anterior talar surface of 10 human cadaveric ankles, at most four defects were arthroscopically created: two pure chondral defects 3 and 1.5 mm in diameter and two osteochondral defects 3 and 1.5 mm in diameter. All ankles were examined by two observers, and their ultrasound observations were validated using computed tomography scans and photographs. Overall sensitivity was 96% for observer 1 and 92% for observer 2, and specificity for both observers was 100%. Sixty-eight percent and 79% of defect sizes were within relevant limits of agreement (-0.2 ± 1.0 mm), respectively. Ultrasound imaging has the potential to detect small (osteo)chondral defects located within visible areas.
authors.affiliation: Department of Biomechanical Engineering, Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Delft, The Netherlands. g.j.m.tuijthof@tudelft.nl
authors.forename: G J M
authors.initials: GJ
authors.lastname: Tuijthof
authors.forename: A C
authors.initials: AC
authors.lastname: Kok
authors.forename: M P
authors.initials: MP
authors.lastname: Terra
authors.forename: J F A
authors.initials: JF
authors.lastname: Aaftink
authors.forename: G J
authors.initials: GJ
authors.lastname: Streekstra
authors.forename: C N
authors.initials: CN
authors.lastname: van Dijk
authors.forename: G M M J
authors.initials: GM
authors.lastname: Kerkhoffs
mesh_terms: D002102:Cadaver; D002357:Cartilage Diseases / Q000000981:diagnostic imaging*; D002358:Cartilage, Articular / Q000000981:diagnostic imaging* / Q000293:injuries*; D050724:Fractures, Cartilage / Q000000981:diagnostic imaging*; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography / Q000379:methods*
keywords: Cartilage; Diagnosis; Human cadaver model; Osteochondral defect; Ultrasound