title: Increase in body temperature during migraine attacks.
abstract: BACKGROUND
  Intermittent fever has been occasionally related to migraine, either as a migraine equivalent or as a migraine accompaniment. We present a case of recurrent increase in body temperature consistently associated with migraine headaches.
  
  
  METHODS
  A 15-year-old girl reported a 3-year lasting history of migraine without aura, with a feeling of warmth occurring in each episode. Ancillary tests did not show any evidence of secondary headaches or any systemic disease. A 2-month headache diary was obtained, with daily records of headache intensity (0, no headache; 1, mild pain; 2, moderate pain; 3, severe pain) and simultaneous measurements of axillary temperature. Both parameters were registered in the evening, at 6:00 pm every day. The distribution of headache intensity and body temperature as well as the relationship between both variables over time were analyzed with nonparametric tests.
  
  
  RESULTS
  The number of days without pain was 28 (45.2%); a mild headache was present on 13 days (21%), a moderate headache on 15 days (24.2%), and a severe headache on 6 days (9.7%). Headache days were associated with higher body temperature than headache-free days (median values: 37.3°C vs 36.6°C; Mann-Whitney U-test, P < 0.001). Moreover, a positive correlation was found between headache intensity and body temperature (Spearman's rho coefficient: 0.83, P < 0.001).
  
  
  CONCLUSIONS
  Recurrent increase in body temperature may be another manifestation of the complex clinical spectrum of migraine. This symptom is probably related to hypothalamic involvement.
authors.affiliation: Department of Neurology, Hospital Clínico San Carlos, Universidad Complutense, Madrid, Spain. ordas.carlos@gmail.com
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Ordás
authors.forename: María L
authors.initials: ML
authors.lastname: Cuadrado
authors.forename: Ana B
authors.initials: AB
authors.lastname: Rodríguez-Cambrón
authors.forename: Javier
authors.initials: J
authors.lastname: Casas-Limón
authors.forename: Náyade
authors.initials: N
authors.lastname: del Prado
authors.forename: Jesús
authors.initials: J
authors.lastname: Porta-Etessam
mesh_terms: D000293:Adolescent; D001831:Body Temperature / Q000502:physiology*; D005260:Female; D005444:Flunarizine / Q000627:therapeutic use; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D008499:Medical Records; D008881:Migraine Disorders / Q000188:drug therapy / Q000503:physiopathology*; D009460:Neurologic Examination; D010147:Pain Measurement; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents; D005444:Flunarizine
keywords: Body Temperature; Fever; Headache; Hypothalamus; Migraine