title: [Expression of Eag1 K(+) channel in prostate cancer and its significance].
abstract: OBJECTIVE
  To investigate the expression of the Eag1 K( +) channel in the prostate cancer (PCa) tissue, its correlation with the development and progression of PCa, and whether it could be a target for the diagnosis and treatment of PCa.
  
  
  METHODS
  We used RT-PCR and immunohistochemistry to determine the mRNA and protein expressions of the Eag1 K(+) channel in the normal peritumoral tissue of androgen-dependent PCa (ADPCa) (group A) and androgen-independent PCa (AIPCa) (group B) as well as in the tumorous tissue of ADPCa (group C) and AIPCa (group D).
  
  
  RESULTS
  The relative coefficients of the mRNA expression of the Eag1 K(+) channel were 0.265 +/- 0.413, 0.167 +/- 0.511, 2.673 +/- 2.988 and 2.815 +/- 2.901 in groups A, B, C and D, respectively, increased significantly in the latter two groups (P < 0.05). The positive rates of the protein expression of the Eag1 K (+) channel were significantly higher in groups C (88.9%) and D (86.7%) than in A (7.4%) and B (6.7%) (P < 0.05).
  
  
  CONCLUSIONS
  The Eag1 K(+) channel might be involved in the pathophysiological processes of PCa, and is expected to be a valuable target for the diagnosis and treatment of PCa.
authors.affiliation: Department of Urology, Zhongshan Hospital Affiliated to Sun Yat-sen University, Zhongshan, Guangdong 528403, China. yiqunzheng70@yahoo.com.cn
authors.forename: Yi-Qun
authors.initials: YQ
authors.lastname: Zheng
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Zhang
authors.forename: Fa-Jiang
authors.initials: FJ
authors.lastname: Li
authors.forename: Ying-Jiang
authors.initials: YJ
authors.lastname: Shi
authors.forename: Gang
authors.initials: G
authors.lastname: Luo
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D051638:Ether-A-Go-Go Potassium Channels / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011467:Prostate / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D051638:Ether-A-Go-Go Potassium Channels; C496884:KCNH1 protein, human; D012333:RNA, Messenger