title: Pd(II)-catalyzed aminotetrazole-directed ortho-selective halogenation of arenes.
abstract: A Pd(II)-catalyzed ortho-selective halogenation of N-aryl ring of N,1-diaryl-1H-tetrazol-5-amine has been described employing N-halosuccinimide as a halogen source via C-H bond activation. The present work features 5-aminotetrazole, as a directing group, for the chemo- and regioselective C-H halogenation of arenes. The kinetic isotope study (kH/kD = 2.9) suggests that the cleavage of the C-H bond takes place in the rate-determining step. The scope and mechanism of the protocol have been demonstrated.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Sadhu
authors.forename: Santhosh Kumar
authors.initials: SK
authors.lastname: Alla
authors.forename: Tharmalingam
authors.initials: T
authors.lastname: Punniyamurthy