title: Current evidence on associations between the MMP-7 (-181A>G) polymorphism and digestive system cancer risk.
abstract: Matrix metalloproteinases (MMPs) degrade various components of the extracellular matrix and functional polymorphisms in encoding genes may contribute to genetic susceptibility to many cancers. Up to now, associations between MMP-7 (-181A>G) and digestive system cancer risk have remained inconclusive. To better understand the role of the MMP-7 (-181A>G) genotype in digestive cancer development, we conducted this comprehensive meta-analysis encompassing 3,518 cases and 4,596 controls. Overall, the MMP-7 (-181A>G) polymorphism was associated with higher digestive system cancer risk on homozygote comparison (GG vs. AA, OR=1.21, 95% CI = 1.12-1.60) and in a dominant model (GG/GA vs. AA, OR=1.16, 95% CI =1.03-1.46). On subgroup analysis, this polymorphism was significantly linked to higher risks for gastric cancer (GG vs. AA, OR=1.22, 95% CI = 1.02- 1.46; GA vs. AA, OR=1.82, 95% CI =1.16-2.87; GG/GA vs. AA, OR=1.13, 95% CI =1.01-1.27; GG vs. GA/AA, OR= 1.25, 95% CI = 1.06-2.39. We also observed increased susceptibility to colorectal cancer and esophageal SCC in both homozygote (OR = 1.13, 95% CI = 1.06-1.26) and heterozygote comparisons (OR = 1.45, 95% CI = 1.11-1.91). In the stratified analysis by controls, significant effects were only observed in population-based studies (GA vs. AA, OR=1.16, 95% CI=1.08-1.50; GA/AA vs. GG, OR=1.10, 95% CI=1.01-1.72). According to the source of ethnicity, a significantly increased risk was found among Asian populations in the homozygote model (GG vs. AA, OR=1.40, 95% CI=1.12-1.69), heterozygote model (GA vs. AA, OR=1.26, 95% CI=1.02-1.51), and dominant model (GG/GA vs. AA, OR=1.18, 95% CI=1.08-1.55). Our findings suggest that the MMP-7 (-181A>G) polymorphism may be a risk factor for digestive system cancer, especially among Asian populations.
authors.affiliation: Department of General Surgery, Xiang-Ya 2nd Hospital, Central South University, Chang-Sha, Hunan, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Ke
authors.forename: Zhong-De
authors.initials: ZD
authors.lastname: Wu
authors.forename: Hua-Song
authors.initials: HS
authors.lastname: Wen
authors.forename: Miao-Xiong
authors.initials: MX
authors.lastname: Ying
authors.forename: Huo-Cheng
authors.initials: HC
authors.lastname: Long
authors.forename: Liu-Guo
authors.initials: LG
authors.lastname: Qing
mesh_terms: D016022:Case-Control Studies; D004067:Digestive System Neoplasms / Q000209:etiology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020783:Matrix Metalloproteinase 7 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7