title: Combining poly(dimethyldiphenylsiloxane) and nitrile phases for improving the separation and quantitation of benzalkonium chloride homologues: In-tube solid phase microextraction-capillary liquid chromatography-diode array detection-mass spectrometry for analyzing industrial samples.
abstract: The retention and separation of four homologues of benzalkonium chloride (alkyl (C12, C14, C16, C18) dimethylbenzylammonium chloride) have been studied in poly(dimethyldiphenylsiloxane) (TRB) and nitrile capillary phases, respectively. Under the optimized conditions (50% acetonitrile in processed samples, 35% of diphenyl content of the TRB, capillary length 43cm and water:methanol 60:40 as replacing solvent), the extraction efficiency was similar for all the homologues with satisfactory reproducibility and independently of the amount and proportion of homologues. Industrial samples with high viscosity or with complex composition and washes waters have been analyzed without previous treatment. The coupling of IT-SPME-CapLC-DAD to MS detection allowed the determination of the minority homologues (C16 and C18) in the industrial samples and washes waters. No matrix effect was found.
authors.affiliation: Departamento de Química Analítica, Facultade de Ciencias, Universidade da Coruña, Campus da Zapateira, E-15071 A Coruña, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Prieto-Blanco
authors.forename: Y
authors.initials: Y
authors.lastname: Moliner-Martinez
authors.forename: P
authors.initials: P
authors.lastname: Campíns-Falcó
mesh_terms: D001548:Benzalkonium Compounds / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification; D002853:Chromatography, Liquid / Q000379:methods*; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D057230:Limit of Detection; D016014:Linear Models; D013058:Mass Spectrometry / Q000379:methods*; D009570:Nitriles / Q000737:chemistry*; D015203:Reproducibility of Results; D052617:Solid Phase Microextraction / Q000379:methods*
chemical_list: D001548:Benzalkonium Compounds; D004129:Dimethylpolysiloxanes; D009570:Nitriles; C528539:poly(dimethyldiphenylsiloxane)