title: Deceased organ donor screening for HIV, hepatitis B, and hepatitis C viruses: a survey of organ procurement organization practices.
abstract: Although Organ Procurement and Transplantation Network (OPTN) policy requires that all potential deceased organ donors are screened for human immunodeficiency (HIV), hepatitis B (HBV) and hepatitis C (HCV) viruses by serology, no current policy requires the use of nucleic acid testing (NAT) for organ donor screening. An electronic survey was sent to 58 organ procurement organizations (OPO) in the United States to assess current screening practices of potential deceased organ donors. Fifty-seven responses were collected for data analysis; not all respondents answered all questions. All OPOs performed required HIV, HBV and HCV serology screening and 48 (84%) performed confirmatory testing for seropositive donors. Ninety-eight percent, 75% and 97% of OPOs performed prospective HIV, HBV and HCV NAT, respectively. Fifty-two percent and 47% used a transcription-mediated amplification assay for HIV and HCV NAT, respectively. Of the 56 respondents that performed HIV NAT and 55 respondents that performed HCV NAT, 39 tested all donors. Seventeen (32%) OPOs performed confirmatory testing for all HIV-positive NAT results, and 15 (27%) OPOs performed confirmatory testing for all HCV-positive NAT results. Since 2008, the number of OPOs performing NAT has increased and more OPOs are testing all donors.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA. nicole.theodoropoulos@osumc.edu
authors.forename: N
authors.initials: N
authors.lastname: Theodoropoulos
authors.forename: A
authors.initials: A
authors.lastname: Jaramillo
authors.forename: D P
authors.initials: DP
authors.lastname: Ladner
authors.forename: M G
authors.initials: MG
authors.lastname: Ison
mesh_terms: D002102:Cadaver; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D018562:Disease Transmission, Infectious / Q000517:prevention & control; D046148:Donor Selection / Q000379:methods*; D005820:Genetic Testing; D006678:HIV / Q000235:genetics / Q000302:isolation & purification; D015658:HIV Infections / Q000175:diagnosis* / Q000517:prevention & control / Q000635:transmission; D019538:Health Care Surveys; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification; D006509:Hepatitis B / Q000175:diagnosis* / Q000517:prevention & control / Q000635:transmission; D006515:Hepatitis B virus / Q000235:genetics / Q000302:isolation & purification; D006526:Hepatitis C / Q000175:diagnosis* / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D016377:Organ Transplantation; D012698:Serologic Tests; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting / Q000592:standards*
chemical_list: D004279:DNA, Viral
keywords: Deceased organ donor; HIV; hepatitis B; hepatitis C; nucleic acid testing; organ procurement organization; screening; survey