title: Integrated electrode and high density feedthrough system for chip-scale implantable devices.
abstract: High density feedthroughs have been developed which allow for the integration of chip-scale features and electrode arrays with up to 1141 stimulating sites to be located on a single implantable package. This layered technology displays hermetic properties and can be produced from as little as two laminated 200 μm thick alumina sheets. It can also be expanded to a greater number of layers to allow flexible routing to integrated electronics. The microelectrodes, which are produced from sintered platinum (Pt) particulate, have high charge injection capacity as a result of a porous surface morphology. Despite their inherent porosity the electrodes are electrically stable following more than 1.8 billion stimulation pulses delivered at clinically relevant levels. The ceramic-Pt constructs are also shown to have acceptable biological properties, causing no cell growth inhibition using standard leachant assays and support neural cell survival and differentiation under both passive conditions and active electrical stimulation.
authors.affiliation: Graduate School of Biomedical Engineering, Sydney, NSW 2052, Australia. r.green@unsw.edu.au
authors.forename: Rylie A
authors.initials: RA
authors.lastname: Green
authors.forename: Thomas
authors.initials: T
authors.lastname: Guenther
authors.forename: Christoph
authors.initials: C
authors.lastname: Jeschke
authors.forename: Amandine
authors.initials: A
authors.lastname: Jaillon
authors.forename: Jin F
authors.initials: JF
authors.lastname: Yu
authors.forename: Wolfram F
authors.initials: WF
authors.lastname: Dueck
authors.forename: William W
authors.initials: WW
authors.lastname: Lim
authors.forename: William C
authors.initials: WC
authors.lastname: Henderson
authors.forename: Anne
authors.initials: A
authors.lastname: Vanhoestenberghe
authors.forename: Nigel H
authors.initials: NH
authors.lastname: Lovell
authors.forename: Gregg J
authors.initials: GJ
authors.lastname: Suaning
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D002448:Cell Adhesion; D049109:Cell Proliferation; D002516:Ceramics / Q000737:chemistry / Q000378:metabolism; D004567:Electrodes, Implanted; D004867:Equipment Design; D008839:Microelectrodes; D016716:PC12 Cells; D010984:Platinum / Q000737:chemistry* / Q000378:metabolism; D051381:Rats
chemical_list: D001672:Biocompatible Materials; D010984:Platinum; D000537:Aluminum Oxide