title: Procedural success and long-term outcomes of aspiration thrombectomy for the treatment of stent thrombosis.
abstract: BACKGROUND
  Stent thrombosis (ST) is associated with a significant burden of coronary thrombus and potential microvascular obstruction. Aspiration thrombectomy may decrease the extent of microvascular obstruction in patients with acute myocardial infarction but its role in the treatment of ST is uncertain. The present study sought to evaluate the association between aspiration thrombectomy, procedural success and long-term outcomes among patients presenting with ST.
  
  
  METHODS
  In a multicenter cohort of patients with definite ST, procedural success, long-term mortality, and major adverse cardiovascular events (death, stroke, re-infarction, revascularization) were ascertained. Propensity weighting was used to determine the association between aspiration thrombectomy and long-term outcomes.
  
  
  RESULTS
  A total of 205 patients with ST were identified. Among these, 115 (56%) patients underwent adjunctive aspiration thrombectomy during percutaneous coronary intervention. Patients undergoing aspiration thrombectomy were more likely to present with ST-elevation myocardial infarction (75% vs. 52%, P < 0.003) and require hemodynamic support (19% vs. 10%, P = 0.07). Aspiration thrombectomy was associated with improved procedural outcomes including postprocedural TIMI 3 flow, resulting in higher angiographic and procedural success (each 96% vs. 83%, P < 0.001). Despite improved angiographic outcomes, the use of aspiration thrombectomy was not associated with a difference in long-term mortality (adjusted HR 0.99, 95% CI 0.44-2.24) or major adverse cardiovascular events (adjusted HR 1.06, 95% CI 0.45-2.48).
  
  
  CONCLUSIONS
  Aspiration thrombectomy is associated with improved coronary flow and procedural success but is not associated with improved long-term outcomes among patients undergoing percutaneous intervention for definite ST.
  
  
  BACKGROUND
  NCT00931502 (http://www.clinicaltrials.gov/ct2/show/NCT00931502)
authors.affiliation: Department of Medicine, Division of Cardiology, University of California, San Francisco, California.
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Waldo
authors.forename: Ehrin J
authors.initials: EJ
authors.lastname: Armstrong
authors.forename: Khung-Keong
authors.initials: KK
authors.lastname: Yeo
authors.forename: Mitul
authors.initials: M
authors.lastname: Patel
authors.forename: Ryan
authors.initials: R
authors.lastname: Reeves
authors.forename: John S
authors.initials: JS
authors.lastname: Macgregor
authors.forename: Reginald I
authors.initials: RI
authors.lastname: Low
authors.forename: Ehtisham
authors.initials: E
authors.lastname: Mahmud
authors.forename: Jason H
authors.initials: JH
authors.lastname: Rogers
authors.forename: Kendrick
authors.initials: K
authors.lastname: Shunk
mesh_terms: D000368:Aged; D002140:California; D017023:Coronary Angiography; D003326:Coronary Circulation; D003328:Coronary Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D015607:Stents; D013396:Suction; D017131:Thrombectomy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D013997:Time Factors; D016896:Treatment Outcome
keywords: acute coronary syndromes; aspiration thrombectomy; stent thrombosis