title: Genetic susceptibility variants associated with colorectal cancer prognosis.
abstract: Colorectal cancer (CRC) is the second leading cause of cancer-related death among men and women in Western countries. Once a tumour develops, a differentiated prognosis could be determined by lifestyle habits or inherited and somatic genetic factors. Finding such prognostic factors will be helpful in order to identify cases with a shorter survival or at a higher risk of recurrence that may benefit from more intensive treatment and follow-up surveillance. Sixteen CRC genetic susceptibility variants were directly genotyped in a cohort of 1235 CRC patients recruited by the EPICOLON Spanish consortium. Univariate Cox and multivariate regression analyses were performed taking as primary outcomes overall survival (OS), disease-free survival and recurrence-free interval. Genetic variants rs9929218 at 16q22.1 and rs10795668 at 10p14 may have an effect on OS. The G allele of rs9929218 was linked with a better OS [GG genotype, genotypic model: hazard ratio (HR) = 0.65, 95% confidence interval (CI) 0.45-0.93, P = 0.0179; GG/GA genotypes, dominant model: HR = 0.66, 95% CI 0.47-0.94, P = 0.0202]. Likewise, the G allele of rs10795668 was associated with better clinical outcome (GG genotype, genotypic model: HR = 0.73, 95% CI 0.53-1.01, P = 0.0570; GA genotype, genotypic model: HR = 0.66, 95% CI 0.47-0.92, P = 0.0137; GG/GA genotypes, dominant model: HR = 0.68, 95% CI 0.50-0.94, P = 0.0194). In conclusion, CRC susceptibility variants rs9929218 and rs10795668 may exert some influence in modulating patient's survival and they deserve to be further tested in additional CRC cohorts in order to confirm their potential as prognosis or predictive biomarkers.
authors.affiliation: Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia 08036, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Abulí
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Lozano
authors.forename: María
authors.initials: M
authors.lastname: Rodríguez-Soler
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Jover
authors.forename: Xavier
authors.initials: X
authors.lastname: Bessa
authors.forename: Jenifer
authors.initials: J
authors.lastname: Muñoz
authors.forename: Clara
authors.initials: C
authors.lastname: Esteban-Jurado
authors.forename: Ceres
authors.initials: C
authors.lastname: Fernández-Rozadilla
authors.forename: Angel
authors.initials: A
authors.lastname: Carracedo
authors.forename: Clara
authors.initials: C
authors.lastname: Ruiz-Ponte
authors.forename: Joaquín
authors.initials: J
authors.lastname: Cubiella
authors.forename: Francesc
authors.initials: F
authors.lastname: Balaguer
authors.forename: Luis
authors.initials: L
authors.lastname: Bujanda
authors.forename: Josep M
authors.initials: JM
authors.lastname: Reñé
authors.forename: Juan
authors.initials: J
authors.lastname: Clofent
authors.forename: Juan Diego
authors.initials: JD
authors.lastname: Morillas
authors.forename: David
authors.initials: D
authors.lastname: Nicolás-Pérez
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Xicola
authors.forename: Xavier
authors.initials: X
authors.lastname: Llor
authors.forename: Josep M
authors.initials: JM
authors.lastname: Piqué
authors.forename: Montserrat
authors.initials: M
authors.lastname: Andreu
authors.forename: Antoni
authors.initials: A
authors.lastname: Castells
authors.forename: Sergi
authors.initials: S
authors.lastname: Castellví-Bel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011159:Population Surveillance; D011379:Prognosis