title: Anterior temporal lobectomy with amygdalohippocampectomy for mesial temporal sclerosis: predictors of long-term seizure control.
abstract: OBJECTIVE
  In this paper the authors' goal was to identify preoperative variables that predict long-term seizure freedom among patients with mesial temporal sclerosis (MTS) after single-stage anterior temporal lobectomy and amygdalohippocampectomy (ATL-AH).
  
  
  METHODS
  The authors retrospectively reviewed 116 consecutive patients (66 females, mean age at surgery 40.7 years) with refractory seizures and pathologically confirmed MTS who underwent ATL-AH with at least 2 years of follow-up. All patients underwent preoperative MRI and video-electroencephalography (EEG); 106 patients (91.4%) underwent Wada testing and 107 patients (92.2%) had neuropsychological evaluations. The authors assessed the concordance of these 4 studies (defined as test consistent with the side of eventual surgery) and analyzed the impact of preoperative variables on seizure freedom.
  
  
  RESULTS
  The median follow-up after surgery was 6.7 years (mean 6.9 years). Overall, 103 patients (89%) were seizure free, and 109 patients (94%) had Engel Class I or II outcome. Concordant findings were highest for video-EEG (100%), PET (100%), MRI (99.0%), and Wada testing (90.4%) and lowest for SPECT (84.6%) and neuropsychological testing (82.5%). Using binary logistic regression analysis (seizure free or not) and Cox proportional hazard analysis (seizure-free survival), less disparity in the Wada memory scores between the ipsilateral and contralateral sides was associated with persistent seizures.
  
  
  CONCLUSIONS
  Seizure freedom of nearly 90% can be achieved with ATL-AH in properly selected patients with MTS and concordant preoperative studies. The low number of poor outcomes and exclusion of multistage patients limit the statistical power to determine preoperative variables that predict failure. Strong Wada memory lateralization was associated with excellent long-term outcome and adds important localization information to structural and neurophysiological data in predicting outcome after ATL-AH for MTS.
authors.affiliation: Neurosurgical Care, LLC, Royersford, PA, USA. robertelliottmd@gmail.com
authors.forename: Robert E
authors.initials: RE
authors.lastname: Elliott
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Bollo
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Berliner
authors.forename: Alyson
authors.initials: A
authors.lastname: Silverberg
authors.forename: Chad
authors.initials: C
authors.lastname: Carlson
authors.forename: Eric B
authors.initials: EB
authors.lastname: Geller
authors.forename: William B
authors.initials: WB
authors.lastname: Barr
authors.forename: Orrin
authors.initials: O
authors.lastname: Devinsky
authors.forename: Werner K
authors.initials: WK
authors.lastname: Doyle
mesh_terms: D000328:Adult; D038481:Anterior Temporal Lobectomy; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012640:Seizures; D013702:Temporal Lobe / Q000601:surgery*; D016896:Treatment Outcome