title: Clinical pharmacology = disease progression + drug action.
abstract: Clinical pharmacology is concerned with understanding how to use medicines to treat disease. Pharmacokinetics and pharmacodynamics have provided powerful methodologies for describing the time course of concentration and effect in individuals and in populations. This population approach may also be applied to describing the progression of disease and the action of drugs to change disease progress. Quantitative models for symptomatic and disease-modifying effects of drugs are valuable not only for describing drugs and diseases but also for identifying criteria to distinguish between types of drug actions, with implications for regulatory decisions and long-term patient care.
authors.affiliation: Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand.
authors.forename: Nick
authors.initials: N
authors.lastname: Holford
mesh_terms: D018450:Disease Progression; D004358:Drug Therapy / Q000706:statistics & numerical data*; D006801:Humans; D008954:Models, Biological; D010601:Pharmacology, Clinical / Q000706:statistics & numerical data*
keywords: Alzheimer's; Parkinson's disease; depression; disease progression; osteoporosis