title: Genetic variability related to serum uric acid concentration and risk of Parkinson's disease.
abstract: BACKGROUND
  Low serum uric acid (UA) levels have been associated with increased Parkinson's disease (PD) risk and accelerated disease progression. We analyzed the effect of polymorphisms in 9 genes influencing serum UA concentration on the risk of PD.
  
  
  METHODS
  We genotyped SLC2A9 rs734553, ABCG2 rs2231142, SLC17A1 rs1183201, SLC22A11 rs17300741, SLC22A12 rs505802, GCKR rs780094, PDZK1 rs12129861, LRRC16A+SCGN rs742132, and SLC16A9 rs12356193 in 1061 PD patients and 754 controls. For each subject we calculated a cumulative genetic risk score (GRS), defined as the total number of PD-risk alleles (range, 2-15) associated to lower serum UA levels. Serum UA levels were measured in a subgroup of 365 PD cases and 132 controls.
  
  
  RESULTS
  Serum UA levels were significantly lower in men with PD than in controls. Subjects (both men and women) carrying more than 9 risk alleles (third GRS tertile) had a 1.5 higher risk of developing PD than subjects with less than 8 risk alleles (first GRS tertile). An inverse correlation was observed between higher GRS and lower serum UA concentration in both men and women.
  
  
  CONCLUSIONS
  Genetic variability influencing serum UA levels might modify susceptibility to PD.
authors.affiliation: Service of Neurology, Universitary Hospital Marqués de Valdecilla (IFIMAV), University of Cantabria (UC), Santander, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: González-Aramburu
authors.forename: Pascual
authors.initials: P
authors.lastname: Sánchez-Juan
authors.forename: Silvia
authors.initials: S
authors.lastname: Jesús
authors.forename: Ana
authors.initials: A
authors.lastname: Gorostidi
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fernández-Juan
authors.forename: Fátima
authors.initials: F
authors.lastname: Carrillo
authors.forename: María
authors.initials: M
authors.lastname: Sierra
authors.forename: Pilar
authors.initials: P
authors.lastname: Gómez-Garre
authors.forename: María T
authors.initials: MT
authors.lastname: Cáceres-Redondo
authors.forename: José
authors.initials: J
authors.lastname: Berciano
authors.forename: Javier
authors.initials: J
authors.lastname: Ruiz-Martínez
authors.forename: Onofre
authors.initials: O
authors.lastname: Combarros
authors.forename: Pablo
authors.initials: P
authors.lastname: Mir
authors.forename: Jon
authors.initials: J
authors.lastname: Infante
mesh_terms: D000368:Aged; D000483:Alleles; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood / Q000235:genetics*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Parkinson's disease; genetics; uric acid