title: [Experimental nephrolithiasis: nephroprotective effect of calcium antagonists].
abstract: Increasing intracellular calcium ion concentration in the cytoplasm is the starting point in the activation of cell death. Regulation of these pathological processes in various organs and tissues is possible using agents from the group of calcium antagonists. This study was aimed at assessing the level of urinary excretion of two enzymes, lactate dehydrogenase (LDH, EC 1.1.1.27) and y-glutamyltransferase (GGT, EC 2.3.2.2), calcium antagonists in an experimental model of nephrolithiasis and finding ways to pharmacological protection of the kidneys. It established that the use of calcium antagonists can reduce the excretion of LDH by 20% and the excretion of GGT by more than 40%.
authors.forename: A B
authors.initials: AB
authors.lastname: Bat'ko
authors.forename: R A
authors.initials: RA
authors.lastname: Oseshniuk
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D019610:Cytoprotection; D004195:Disease Models, Animal; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000652:urine; D008297:Male; D053040:Nephrolithiasis / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control* / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D019459:Urothelium / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D005723:gamma-Glutamyltransferase / Q000652:urine
chemical_list: D002121:Calcium Channel Blockers; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D002118:Calcium