title: Hepcidin and iron metabolism disorders in patients with chronic kidney disease.
abstract: OBJECTIVE
  [corrected] Hepcidin may play a pathogenetic role in iron metobolism disorders. The aim of this study was to determine the correlation between hepcidin concentration and parameters of iron metabolism in patients with different stage of chronic kidney disease (CKD).
  
  
  METHODS
  The study involved 104 patients with CKD: 64 on hemodialysis (HD) and 40 patients in pre-dialysis stadium (pre-HD) with adequate erythropoetin therapy and iron supplementation. The HD group was divided in four subgroups according to the level of serum ferritin (up to 100; 100-199; 200-499 and over 500 ng/mL). Parameters of anemia, iron status, in flamation and hepcidin level were evaluated.
  
  
  RESULTS
  The HD patients had a significantly lower eritrocyte count, erythrocytes indexes, hemoglobin and transferrin saturation and significantly higher iron, ferritin, hepcidin and total iron binding capacity (TIBC). The HD subgroups up to 199 ng/mL of serum feritin had lower high-sensitivity C-reactive protein (hsCRP), iron and higher unbuffered iron binding capacity (UIBC), transferrin saturation and TIBC compared to the HD subgroups over 200 ng/mL. The lowest and the highest ferritin subgroups had the highest hepcidin level and it showed significant correlation with ferritin.
  
  
  CONCLUSIONS
  Hepcidin may serve as a marker for better diagnosing and monitoring anemia and iron metabolism disorders in CKD.
authors.affiliation: Clinical Biochemical Laboratory, Military Hospital Nis, Nis, Serbia. jelicmarija1211@gmail.com
authors.forename: Marija
authors.initials: M
authors.lastname: Jelić
authors.forename: Tatjana
authors.initials: T
authors.lastname: Cvetković
authors.forename: Vidojko
authors.initials: V
authors.lastname: Djordjević
authors.forename: Goran
authors.initials: G
authors.lastname: Damnjanovć
authors.forename: Predrag
authors.initials: P
authors.lastname: Vlahović
authors.forename: Gordana
authors.initials: G
authors.lastname: Kocić
authors.forename: Natasa
authors.initials: N
authors.lastname: Djindjić
authors.forename: Biljana
authors.initials: B
authors.lastname: Jovović
authors.forename: Ana
authors.initials: A
authors.lastname: Antić
mesh_terms: D000368:Aged; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism*; D005260:Female; D005293:Ferritins / Q000097:blood; D064451:Hepcidins; D006801:Humans; D019189:Iron Metabolism Disorders / Q000150:complications / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D014168:Transferrin / Q000032:analysis
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D014168:Transferrin; D005293:Ferritins