title: Development and validation of a method for the determination of 159 pesticide residues in tobacco by gas chromatography-tandem mass spectrometry.
abstract: A multiresidue gas chromatography-tandem mass spectrometry (GC-MS/MS) method was developed for the analysis of 159 multiclass pesticides in tobacco. A modified QuEChERS sample preparation technique, based on acetonitrile extraction and toluene dilution, followed by dispersive solid-phase extraction (d-SPE) cleanup using primary-secondary amine (PSA) and octadecyl (C18) sorbents, was used for sample treatment. Key performance parameters investigated were linearity, recovery, relative standard deviation (RSD), limit of detection, and limit of quantitation. With the exception of chinomethionate and folpet, recoveries for pesticides ranged from 69 to 141%, and the RSDs ranged from 2 to 27%. The validated method was applied to the analysis of 118 real samples, and positive results were obtained for 116 samples, with 25 different pesticides being detected.
authors.affiliation: China National Tobacco Quality Supervision and Test Center , No. 2 Fengyang Street, Zhengzhou High and New Technology Industries Development Zone, Zhengzhou 450001, China.
authors.forename: Xiaoshui
authors.initials: X
authors.lastname: Chen
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Bian
authors.forename: Hongwei
authors.initials: H
authors.lastname: Hou
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
authors.forename: Shanshan
authors.initials: S
authors.lastname: Liu
authors.forename: Gangling
authors.initials: G
authors.lastname: Tang
authors.forename: Qingyuan
authors.initials: Q
authors.lastname: Hu
mesh_terms: D053000:Analytic Sample Preparation Methods; D002681:China; D003257:Consumer Product Safety; D018556:Crops, Agricultural / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D057230:Limit of Detection; D010573:Pesticide Residues / Q000032:analysis* / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D052616:Solid Phase Extraction; D053719:Tandem Mass Spectrometry; D062789:Tobacco Products / Q000032:analysis*
chemical_list: D010573:Pesticide Residues