title: Photosensitizer-loaded gold vesicles with strong plasmonic coupling effect for imaging-guided photothermal/photodynamic therapy.
abstract: A multifunctional theranostic platform based on photosensitizer-loaded plasmonic vesicular assemblies of gold nanoparticles (GNPs) is developed for effective cancer imaging and treatment. The gold vesicles (GVs) composed of a monolayer of assembled GNPs show strong absorbance in the near-infrared (NIR) range of 650-800 nm, as a result of the plasmonic coupling effect between neighboring GNPs in the vesicular membranes. The strong NIR absorption and the capability of encapsulating photosensitizer Ce6 in GVs enable trimodality NIR fluorescence/thermal/photoacoustic imaging-guided synergistic photothermal/photodynamic therapy (PTT/PDT) with improved efficacy. The Ce6-loaded GVs (GV-Ce6) have the following characteristics: (i) high Ce6 loading efficiency (up to ~18.4 wt %; (ii) enhanced cellular uptake efficiency of Ce6; (iii) simultaneous trimodality NIR fluorescence/thermal/photoacoustic imaging; (iv) synergistic PTT/PDT treatment with improved efficacy using single wavelength continuous wave laser irradiation.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.forename: Shouju
authors.initials: S
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.forename: Shouhui
authors.initials: S
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Niu
authors.forename: Wanwan
authors.initials: W
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: He
authors.forename: Daxiang
authors.initials: D
authors.lastname: Cui
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Nie
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D057054:Molecular Imaging; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D004337:Drug Carriers; D017319:Photosensitizing Agents; D006046:Gold