title: Correlation of chronic periodontitis in tropical area and IFN-γ, IL-10, IL-17 levels.
abstract: OBJECTIVE
  To evaluate the correlation of chronic periodontitis in tropical area and IFN-γ, IL-10 and IL-17 levels.
  
  
  METHODS
  One hundred and forty-eight patients and one hundred and thirty-two healthy control subjects were included in the study. Clinical parameters (PI, GI and PD) and GCF levels of IFN-γ, IL-10 and IL-17 were measured at baseline, week 8, week 16 and week 24 after mechanical removal of dental plaque. IFN-γ and IL-10 were determined with ELISA methods and IL-17 was determined with the cytometric bead array.
  
  
  RESULTS
  Removal of dental plaque resulted in improvement in all clinical parameters. Meanwhile, GCF IL-17 declined to control levels, while GCF IFN-γ and IL-10 levels remained unchanged.
  
  
  CONCLUSIONS
  The decline of GCF IL-17 levels in patients with resolution of periodontitis suggests that IL-17 is involved in the periodontal inflammatory process.
authors.affiliation: Department of Stomatology, Affiliated Hospital of Hainan Medical University, Haikou 571101, China. 13078955623@wo.com.cn
authors.forename: Qi-Ya
authors.initials: QY
authors.lastname: Fu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Duan
authors.forename: Shi-Yun
authors.initials: SY
authors.lastname: Qian
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Pang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D055113:Chronic Periodontitis / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy; D012534:Dental Scaling; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D016753:Interleukin-10 / Q000276:immunology*; D020381:Interleukin-17 / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014329:Tropical Climate
chemical_list: C508609:IL10 protein, human; D020381:Interleukin-17; D016753:Interleukin-10; D007371:Interferon-gamma