title: Orthogonal adsorption onto nano-graphene oxide using different intermolecular forces for multiplexed delivery.
abstract: Nano-graphene oxide can adsorb both doxorubicin and zwitterionic dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes in an orthogonal and non-competing manner with high capacities based on different surface and intermolecular forces taking place on the heterogeneous surface of the graphene oxide. The system forms stable colloids, allowing co-delivery of both cargos to cancer cells.
authors.affiliation: Department of Chemistry and Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Biwu
authors.initials: B
authors.lastname: Liu
authors.forename: Alexander C-F
authors.initials: AC
authors.lastname: Ip
authors.forename: Juewen
authors.initials: J
authors.lastname: Liu
mesh_terms: D000327:Adsorption; D002470:Cell Survival / Q000187:drug effects; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D006108:Graphite / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008422:Materials Testing; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry*; D013314:Stress, Mechanical
chemical_list: D053769:Nanocapsules; D010087:Oxides; D010713:Phosphatidylcholines; D006108:Graphite; D004317:Doxorubicin; C017251:1,2-oleoylphosphatidylcholine
keywords: adsorption; drug delivery; graphene oxide; liposomes