title: Alberta Stroke Program Early CT Scale evaluation of multimodal computed tomography in predicting clinical outcomes of stroke patients treated with aspiration thrombectomy.
abstract: OBJECTIVE
  Patient selection is crucial in the endovascular treatment of acute ischemic stroke patients. Baseline computed tomographic (CT) images, evaluated with the Alberta Stroke Program Early CT Scale (ASPECTS), are considered significant predictors of outcome. In this study, we evaluated CT images and perfusion parameters, analyzed with ASPECTS, as final outcome predictors after endovascular stroke treatment.
  
  
  METHODS
  We analyzed a cohort of patients with acute ischemic stroke and endovascular treatment. Patients with an occlusion of the M1 segment and multimodal CT imaging were included. CT perfusion data were reconstructed using commercial software. Two experienced neuroradiologists separately reviewed and scored CT and CT perfusion images with the ASPECTS score. Parameters were compared between patients with poor and with favorable follow-up outcome. Significantly different variables were further analyzed by forward stepwise logistic regression.
  
  
  RESULTS
  Fifty-one patients were included in our study. Baseline characteristics did not differ between patients with favorable and poor outcomes. No significant difference in recanalization status, the various times, or CT ASPECTS was demonstrated between these 2 groups. Significant differences were demonstrated for age (P=0.0049), cerebral blood volume ASPECTS (P=0.0007), and between cerebral blood volume and cerebral blood flow ASPECTS (P=0.0045). Cerebral blood volume ASPECTS>7 demonstrated the highest sensitivity and specificity for favorable outcome with 84% and 79%, respectively.
  
  
  CONCLUSIONS
  CT perfusion parameters, evaluated with ASPECTS, are optimal predictors of outcome and are more sensitive and specific than CT ASPECTS in the prediction of favorable outcome. Use of these parameters in treatment decisions could reduce futile recanalizations.
authors.affiliation: Department of Neuroradiology, University Medicine Goettingen, Goettingen, Germany. m.psychogios@med.uni-goettingen.de
authors.forename: Marios-Nikos
authors.initials: MN
authors.lastname: Psychogios
authors.forename: Peter
authors.initials: P
authors.lastname: Schramm
authors.forename: Andreas Maximilian
authors.initials: AM
authors.lastname: Frölich
authors.forename: Kai
authors.initials: K
authors.lastname: Kallenberg
authors.forename: Katrin
authors.initials: K
authors.lastname: Wasser
authors.forename: Lars
authors.initials: L
authors.lastname: Reinhardt
authors.forename: Andreas S
authors.initials: AS
authors.lastname: Kreusch
authors.forename: Klaus
authors.initials: K
authors.lastname: Jung
authors.forename: Michael
authors.initials: M
authors.lastname: Knauth
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000145:classification / Q000000981:diagnostic imaging* / Q000601:surgery; D015331:Cohort Studies; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D020521:Stroke / Q000145:classification / Q000000981:diagnostic imaging* / Q000601:surgery; D017131:Thrombectomy / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
keywords: CBV ASPECTS; CT ASPECTS; favorable outcome; mechanical thrombectomy; multimodal CT; stroke