title: The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer.
abstract: BACKGROUND
  TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs) in its miRNA binding sites could modulate functions of the miRNA-target genes and thus risk of cancers. In this study, we investigated associations between potentially functional SNPs in the miRNA binding sites of the 3'UTR of TNFAIP2 and gastric cancer risk in a US population.
  
  
  METHODS
  We conducted a case-control study of 301 gastric cancer patients and 313 cancer-free controls frequency-matched by age, sex and ethnicity. We genotyped four selected TNFAIP2 SNPs (rs8126 T>C, rs710100 G>A, rs1052912 G>A and rs1052823 G>T) and used the logistic regression analysis to assess associations of these SNPs with cancer risk.
  
  
  RESULTS
  The rs8126 CC genotype was associated with a significantly elevated risk of gastric cancer (adjusted OR = 2.00, 95% CI = 1.09-3.64 and P = 0.024), compared with the combined rs8126 TT+TC genotypes, particularly in current drinkers. However, none of other TNFAIP2 SNPs was associated with risk of gastric cancer.
  
  
  CONCLUSIONS
  Our data suggested that the TNFAIP2 miRNA binding site rs8126 T>C SNP may be a marker for susceptibility to gastric cancer, and this finding requires further validation by larger studies.
authors.affiliation: Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America. xuyudaniel@gmail.com
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.forename: Hongxia
authors.initials: H
authors.lastname: Ma
authors.forename: Hongping
authors.initials: H
authors.lastname: Yu
authors.forename: Zhensheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Li-E
authors.initials: LE
authors.lastname: Wang
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Tan
authors.forename: Ramya
authors.initials: R
authors.lastname: Muddasani
authors.forename: Victoria
authors.initials: V
authors.lastname: Lu
authors.forename: Jaffer A
authors.initials: JA
authors.lastname: Ajani
authors.forename: Yanong
authors.initials: Y
authors.lastname: Wang
authors.forename: Qingyi
authors.initials: Q
authors.lastname: Wei
mesh_terms: D001665:Binding Sites / Q000235:genetics; D016207:Cytokines / Q000235:genetics*; D003710:Demography; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D016015:Logistic Models; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D016207:Cytokines; C534424:MIRN184 microRNA, human; D035683:MicroRNAs; C085839:TNFAIP2 protein, human