title: Molecularly-imprinted nanoparticles that recognize Naja mossambica cytotoxins: binding studies and biological effects.
abstract: We report the development of molecularly imprinted polyacrylamide nanoparticles that bind to and neutralize the activity of cytotoxins present in the venom of the Mozambique Spitting Cobra (Naja mossambica mossambica). The binding activity of these nanoparticles is avid and specific. These findings hold promise for the development of a synthetic antivenom.
authors.affiliation: Department of Chemistry, Laguna Beach High School, California 92651, USA.
authors.forename: Samantha
authors.initials: S
authors.lastname: Piszkiewicz
authors.forename: Evan A
authors.initials: EA
authors.lastname: Kirkbride
authors.forename: Nicolai
authors.initials: N
authors.lastname: Doreng-Stearns
authors.forename: Blake R
authors.initials: BR
authors.lastname: Henderson
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Lenker
authors.forename: Erika
authors.initials: E
authors.lastname: Tang
authors.forename: Laura H
authors.initials: LH
authors.lastname: Kawashiri
authors.forename: Curtis S
authors.initials: CS
authors.lastname: Nichols
authors.forename: Sebastian C
authors.initials: SC
authors.lastname: Moore
authors.forename: Steven G
authors.initials: SG
authors.lastname: Sogo
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D004179:Cobra Cardiotoxin Proteins / Q000737:chemistry*; D003603:Cytotoxins / Q000737:chemistry*; D054802:Molecular Imprinting; D053758:Nanoparticles / Q000737:chemistry*; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D004179:Cobra Cardiotoxin Proteins; D003603:Cytotoxins; D000099166:Polyacrylamides