title: Impact of stent mis-sizing and mis-positioning on coronary fluid wall shear and intramural stress.
abstract: Stent deployments with geographical miss (GM) are associated with increased risk of target-vessel revascularization and periprocedural myocardial infarction. The aim of the current study was to investigate the underlying biomechanical mechanisms for adverse events with GM. The hypothesis is that stent deployment with GM [longitudinal GM, or LGM (i.e., stent not centered on the lesion); or radial GM, RGM (i.e., stent oversizing)] results in unfavorable fluid wall shear stress (WSS), WSS gradient (WSSG), oscillatory shear index (OSI), and intramural circumferential wall stress (CWS). Three-dimensional computational models of stents and plaque were created using a computer-assisted design package. The models were then solved with validated finite element and computational fluid dynamic packages. The dynamic process of large deformation stent deployment was modeled to expand the stent to the desired vessel size. Stent deployed with GM resulted in a 45% increase in vessel CWS compared with stents that were centered and fully covered the lesion. A 20% oversized stent resulted in 72% higher CWS than a correct sized stent. The linkages between the struts had much higher stress than the main struts (i.e., 180 MPa vs. 80 MPa). Additionally, LGM and RGM reduced endothelial WSS and increased WSSG and OSI. The simulations suggest that both LGM and RGM adversely reduce WSS but increase WSSG, OSI, and CWS. These findings highlight the potential mechanical mechanism of the higher adverse events and underscore the importance of stent positioning and sizing for improved clinical outcome.
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
authors.forename: Henry Y
authors.initials: HY
authors.lastname: Chen
authors.forename: Bon-Kwon
authors.initials: BK
authors.lastname: Koo
authors.forename: Deepak L
authors.initials: DL
authors.lastname: Bhatt
authors.forename: Ghassan S
authors.initials: GS
authors.lastname: Kassab
mesh_terms: D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D003198:Computer Simulation; D017076:Computer-Aided Design; D008955:Models, Cardiovascular; D011474:Prosthesis Design / Q000379:methods*; D033081:Shear Strength / Q000502:physiology; D015607:Stents / Q000009:adverse effects*; D013314:Stress, Mechanical
keywords: STLLR trial; adverse events; geographic miss; restenosis; target-vessel revascularization