title: The egg. The inside story of a cell.
abstract: The egg, a fantastic little laboratory of molecular biology, has played a crucial role in redefining modern biology by moving it from the description of living things to the synthesis of living things (synthetic biology). Over the centuries, many hypotheses have been advanced concerning the egg's role in reproduction-from the preformation theory until von Baer's discovery to the present, with the 2012 Nobel Prize for Physiology or Medicine celebrating the egg as a totipotent stem cell able to reprogram fully differentiated somatic nuclei. The molecular dissection of its cytoplasmic components makes the egg an ideal bioreactor for several biotechnological applications, including pharmacological and food production sciences. In addition to its ubiquitous contribution to the worldwide diet, the egg, a powerful symbol, pervades philosophy, art, religion, and idiomatic expressions.
authors.affiliation: Research Center for Regenerative Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. m.monti@smatteo.pv.it
authors.forename: Manuela
authors.initials: M
authors.lastname: Monti
authors.forename: Carloalberto
authors.initials: C
authors.lastname: Redi
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004531:Eggs; D005306:Fertilization / Q000502:physiology; D006801:Humans; D009866:Oogenesis / Q000502:physiology; D010063:Ovum / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D012098:Reproduction / Q000502:physiology*