title: Antihypercholesterolemic effect of Macrotyloma uniflorum (Lam.) Verdc (Fabaceae) extract on high-fat diet-induced hypercholesterolemia in Sprague-Dawley rats.
abstract: OBJECTIVE
  The present study evaluated the antihypercholesterolemic effect of Macrotyloma uniflorum (Lam.) Verdc extract by examining its effects on food consumption, weight gain, serum lipid profile, serum glutamate oxaloacetate transamianse (SGOT), serum glutamate pyruvate transaminase (SGPT), and body fat in rats.
  
  
  METHODS
  Animals were fed with experimental high-fat diets (HFD) that contain 10% lard plus, 5% corn oil. Food intake and body weight were measured. Serum samples were analyzed for the estimation of lipid profiles and other biochemical parameters by using kits.
  
  
  RESULTS
  The consumption of ethanol and water extract of experimental plant for 5 weeks caused the decrease in total cholesterol (TC), triglycerides, low-density lipoprotein (LDL), very low density lipoprotein (VLDL) SGOT and SGPT significantly (p < .01), and increase in high-density lipoprotein (HDL) significantly (p < .01). The rat group fed with HFD has shown higher serum TC, TG, LDL, VLDL, SGOT, SGPT, and lower HDL than in the normal control group (p < .01). Fecal excretion of cholesterol in the ethanol extract-treated groups was significantly higher than those treated with water extract. Body weight in the water extract-treated groups was significantly lower than that in the ethanol extract-treated groups.
  
  
  CONCLUSIONS
  This study demonstrated that M. uniflorum (Lam.) Verdc extracts have strong activities against hypercholesterolemia and obesity suggesting a potential usefulness of M. uniflorum (Lam.) Verdc extracts as functional ingredients.
authors.affiliation: Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, India. satmpdina@yahoo.co.in
authors.forename: D Sathis
authors.initials: DS
authors.lastname: Kumar
authors.forename: G
authors.initials: G
authors.lastname: Prashanthi
authors.forename: Harani
authors.initials: H
authors.lastname: Avasarala
authors.forename: David
authors.initials: D
authors.lastname: Banji
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D001067:Appetite Depressants / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D015992:Body Mass Index; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects; D019587:Dietary Supplements; D007887:Fabaceae / Q000737:chemistry*; D005243:Feces / Q000737:chemistry; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications / Q000209:etiology / Q000517:prevention & control*; D007194:India; D008074:Lipoproteins / Q000097:blood; D009765:Obesity / Q000097:blood / Q000150:complications / Q000209:etiology / Q000517:prevention & control*; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012997:Solvents / Q000737:chemistry; D015430:Weight Gain
chemical_list: D000924:Anticholesteremic Agents; D001067:Appetite Depressants; D008074:Lipoproteins; D010936:Plant Extracts; D012997:Solvents; D002784:Cholesterol