title: Hypolipidemic and antioxidant effects of buckwheat leaf and flower mixture in hyperlipidemic rats.
abstract: As a source of biologically active compounds, buckwheat has beneficial effects in nutrition due to its high content of flavonoids, particularly rutin. Aim of our study was to examine effects of buckwheat on plasma lipid status and phospholipids fatty acids composition, histological and parameters of oxidative stress in Wistar rats fed a high-fat diet. This study showed that buckwheat leaf and flower (BLF) mixture supplementation significantly reduce weight gain, plasma lipid concentrations and atherogenic index in rats fed a high-fat diet. Treatment of the high-fat group of animals with buckwheat significantly increased percentage of n-6 fatty acids as well as eicosapentaenoic acid (EPA) and decreased percentage of saturated fatty acids (SFA) and oleic acid. Buckwheat antioxidant effects diminished negative influence of high-fat diet in hyperlipidemic rats, while pathohistological analysis of liver confirmed changes after high-fat consumption. Our results showed hypolipidemic, antiatherogenic and antioxidative features of buckwheat leaf and flower mixture, and these parts of the plant with the highest rutin content could be beneficial in prevention and curing of hyperlipidemia.
authors.affiliation: Institute of Forensic Medicine, Clinical Center Vojvodina, Hajduk Veljkova 7-9, 21000 Novi Sad, Serbia. maja.brenesel@gmail.com
authors.forename: Maja
authors.initials: M
authors.lastname: Ðurendić-Brenesel
authors.forename: Tamara
authors.initials: T
authors.lastname: Popović
authors.forename: Vladimir
authors.initials: V
authors.lastname: Pilija
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Arsić
authors.forename: Miljan
authors.initials: M
authors.lastname: Milić
authors.forename: Danijela
authors.initials: D
authors.lastname: Kojić
authors.forename: Nikola
authors.initials: N
authors.lastname: Jojić
authors.forename: Nataša
authors.initials: N
authors.lastname: Milić
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015118:Eicosapentaenoic Acid / Q000097:blood; D019612:Fagopyrum / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry; D043371:Fatty Acids, Omega-6 / Q000097:blood; D035264:Flowers / Q000737:chemistry; D006949:Hyperlipidemias; D007009:Hypolipoproteinemias / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D019301:Oleic Acid / Q000097:blood; D018384:Oxidative Stress; D010743:Phospholipids / Q000097:blood; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012431:Rutin / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D005227:Fatty Acids; D043371:Fatty Acids, Omega-6; D008055:Lipids; D010743:Phospholipids; D010936:Plant Extracts; D019301:Oleic Acid; D012431:Rutin; D015118:Eicosapentaenoic Acid