title: [Drug resistance of methicillin resistant Staphylococcus strains in burn ward and relative analysis].
abstract: OBJECTIVE
  To study the distribution and drug resistance of methicillin resistant Staphylococcus strains in various specimens of inpatients in burn wards, and to provide reference for clinical treatment.
  
  
  METHODS
  Bacteria were isolated from specimens of wound exudate, blood, sputum, and bronchoalveolar lavage fluid etc., which were collected from patients hospitalized in our burn wards from January 2008 to December 2010. The bacteria were routinely cultured and identified. Drug resistance of the Staphylococci to 15 antibiotics commonly used in clinic was identified by K-B disk diffusion method. Data were processed with statistical software WHONET 5.5. The homology of 40 strains of methicillin resistant Staphylococcus aureus (MRSA) was analyzed by pulsed-field gel electrophoresis (PFGE).
  
  
  RESULTS
  Altogether 386 strains of Staphylococcus were isolated, including 196 strains of Staphylococcus aureus and 190 strains of coagulase negative Staphylococcus. The mean annual isolation rates of MRSA and methicillin resistant coagulase negative Staphylococcus (MRCoNS) were respectively 73.00% (143/196) and 74.20% (141/190). The resistance rates of MRSA and MRCoNS to β-lactams drugs, such as penicillin, oxacillin, cefazolin, and cefuroxime were 100.00% in every year. No Staphylococcus strains resistant to vancomycin, teicoplanin, or linezolid were found. Three different PFGE patterns A, B, and C were identified among 40 MRSA strains, including 33 strains of type A (30 strains in sub-type A1 and 3 strains in sub-type A2), 6 strains of type B (respectively 3 strains in sub-types B1 and B2), and 1 strain of type C.
  
  
  CONCLUSIONS
  The isolation rates of MRSA and MRCoNS were high in our burn wards from January 2008 to December 2010. All of them showed strong drug resistance property, and they were multidrug resistant. The most prevalent strain was PFGE type A.
authors.affiliation: Clinical Laboratory Center, Gansu Provincial Hospital, Lanzhou 730000, China.
authors.forename: Lian-hua
authors.initials: LH
authors.lastname: Wei
authors.forename: Feng-mei
authors.initials: FM
authors.lastname: Zou
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Jin-ju
authors.initials: JJ
authors.lastname: Deng
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Xue
authors.forename: Jun-li
authors.initials: JL
authors.lastname: Zhou
authors.forename: Li-yuan
authors.initials: LY
authors.lastname: Jiang
authors.forename: Xiao-qiang
authors.initials: XQ
authors.lastname: Si
authors.forename: Jun-ling
authors.initials: JL
authors.lastname: Liu
mesh_terms: D002056:Burns / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*