title: Impact of boost radiation in the treatment of ductal carcinoma in situ: a population-based analysis.
abstract: OBJECTIVE
  To report the outcomes of a population of women with ductal carcinoma in situ (DCIS) treated with breast-conserving surgery and radiation and to evaluate the independent effect of boost radiation on the development of local recurrence.
  
  
  METHODS
  All women diagnosed with DCIS and treated with breast-conserving surgery and radiation therapy in Ontario from 1994 to 2003 were identified. Treatments and outcomes were identified through administrative databases and validated by chart review. The impact of boost radiation on the development of local recurrence was determined using survival analyses.
  
  
  RESULTS
  We identified 1895 cases of DCIS that were treated by breast-conserving surgery and radiation therapy; 561 patients received boost radiation. The cumulative 10-year rate of local recurrence was 13% for women who received boost radiation and 12% for those who did not (P=.3). The 10-year local recurrence-free survival (LRFS) rate among women who did and who did not receive boost radiation was 88% and 87%, respectively (P=.27), 94% and 93% for invasive LRFS (P=.58), and was 95% and 93% for DCIS LRFS (P=.31). On multivariable analyses, boost radiation was not associated with a lower risk of local recurrence (hazard ratio = 0.82, 95% confidence interval 0.59-1.15) (P=.25).
  
  
  CONCLUSIONS
  Among a population of women treated with breast-conserving surgery and radiation for DCIS, additional (boost) radiation was not associated with a lower risk of local or invasive recurrence.
authors.affiliation: Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada. Eileen.rakovitch@sunnybrook.ca
authors.forename: Eileen
authors.initials: E
authors.lastname: Rakovitch
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
authors.forename: Sharon
authors.initials: S
authors.lastname: Nofech-Moses
authors.forename: Wedad
authors.initials: W
authors.lastname: Hanna
authors.forename: Deva
authors.initials: D
authors.lastname: Thiruchelvam
authors.forename: Refik
authors.initials: R
authors.lastname: Saskin
authors.forename: Carole
authors.initials: C
authors.lastname: Taylor
authors.forename: Alan
authors.initials: A
authors.lastname: Tuck
authors.forename: Bruce
authors.initials: B
authors.lastname: Youngson
authors.forename: Naomi
authors.initials: N
authors.lastname: Miller
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Done
authors.forename: Sandip
authors.initials: S
authors.lastname: Sengupta
authors.forename: Leela
authors.initials: L
authors.lastname: Elavathil
authors.forename: Prashant A
authors.initials: PA
authors.lastname: Jani
authors.forename: Michel
authors.initials: M
authors.lastname: Bonin
authors.forename: Stephanie
authors.initials: S
authors.lastname: Metcalfe
authors.forename: Lawrence
authors.initials: L
authors.lastname: Paszat
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001943:Breast Neoplasms / Q000517:prevention & control / Q000532:radiotherapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000517:prevention & control / Q000532:radiotherapy* / Q000601:surgery; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015412:Mastectomy, Segmental; D008505:Medical Staff, Hospital / Q000706:statistics & numerical data; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000517:prevention & control*; D009864:Ontario; D018714:Radiotherapy, Adjuvant / Q000379:methods; D019233:Retreatment / Q000379:methods; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult