title: Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles.
abstract: The trimer of a bradykinin derivative displayed a more than five-fold increase in binding affinity for phosphatidylserine-enriched nanovesicles as compared to its monomeric precursor. The nanovesicle selection is directly correlated with multivalency, which amplifies the electrostatic attraction. This strategy may lead to the development of novel molecular probes for detecting highly curved membrane bilayers.
authors.affiliation: Department of Chemistry & Biochemistry and BioFrontiers Institute, University of Colorado, Boulder, CO 80309, USA.
authors.forename: Jonel P
authors.initials: JP
authors.lastname: Saludes
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Morton
authors.forename: Sara K
authors.initials: SK
authors.lastname: Coulup
authors.forename: Zeno
authors.initials: Z
authors.lastname: Fiorini
authors.forename: Brandan M
authors.initials: BM
authors.lastname: Cook
authors.forename: Lida
authors.initials: L
authors.lastname: Beninson
authors.forename: Edwin R
authors.initials: ER
authors.lastname: Chapman
authors.forename: Monika
authors.initials: M
authors.lastname: Fleshner
authors.forename: Hang
authors.initials: H
authors.lastname: Yin
mesh_terms: D001920:Bradykinin / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008958:Models, Molecular; D015335:Molecular Probes / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D010718:Phosphatidylserines; D055503:Protein Multimerization; D013050:Spectrometry, Fluorescence; D055672:Static Electricity
chemical_list: D008051:Lipid Bilayers; D015335:Molecular Probes; D010455:Peptides; D010718:Phosphatidylserines; D001920:Bradykinin