title: The synthesis of neurotensin antagonist SR 48692 for prostate cancer research.
abstract: An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham DH1 3LE, United Kingdom. i.r.baxendale@durham.ac.uk
authors.forename: I R
authors.initials: IR
authors.lastname: Baxendale
authors.forename: S
authors.initials: S
authors.lastname: Cheung
authors.forename: M O
authors.initials: MO
authors.lastname: Kitching
authors.forename: S V
authors.initials: SV
authors.lastname: Ley
authors.forename: J W
authors.initials: JW
authors.lastname: Shearman
mesh_terms: D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D015394:Molecular Structure; D009496:Neurotensin / Q000037:antagonists & inhibitors*; D011471:Prostatic Neoplasms / Q000188:drug therapy; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011720:Pyrazoles; D011804:Quinolines; C079087:SR 48692; D009496:Neurotensin