title: Exostoses as a long-term sequela after pediatric hematopoietic progenitor cell transplantation: potential causes and increase risk of secondary malignancies from Ann & Robert H. Lurie Children's Hospital of Chicago.
abstract: Allogeneic hematopoietic progenitor cell transplantation (HPCT) is a curative therapy for pediatric patients with both malignant and nonmalignant diseases. Single or multiple benign exostoses or osteochondromas have been reported after total body irradiation (TBI), as well as after focal irradiation. Patients exposed to TBI at a young age are at highest risk of developing exostoses. The objective of this institutional review board-approved study was to look at potential factors, besides radiation, that may play a role in development of exostoses. All patients who underwent allogeneic and autologous HPCT at a single institution between March 1992 and December 2003 and who developed an exostosis identified by clinical findings or as an incidental finding on a radiologic study were included. A case-control design matched patients with controls who had the same stem cell source.
authors.affiliation: Division of Hematology-Oncology-Transplant, Ann & Robert H. Lurie Children's Hospital of Chicago, IL 60611, USA. kdannerkoptik@luriechildrens.org
authors.forename: Karina
authors.initials: K
authors.lastname: Danner-Koptik
authors.forename: Morris
authors.initials: M
authors.lastname: Kletzel
authors.forename: Kimberley J
authors.initials: KJ
authors.lastname: Dilley
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000209:etiology / Q000473:pathology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005096:Exostoses / Q000209:etiology* / Q000473:pathology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007223:Infant; D008297:Male; D015831:Osteochondroma / Q000209:etiology / Q000473:pathology; D012307:Risk Factors; D014184:Transplantation, Homologous
keywords: Benign osteochondromas; Exostoses; Hematopoietic Progenitor Cell Transplant; Pediatrics; Radiation