title: TRAF1-C5 affects quality of life in patients with primary biliary cirrhosis.
abstract: BACKGROUND
  Previous studies reported associations between specific alleles of non-HLA immunoregulatory genes and higher fatigue scores in patients with primary biliary cirrhosis (PBC).
  
  
  OBJECTIVE
  To study the relationship between variables of health-related quality of life (HRQoL) and single nucleotide polymorphisms of TRAF1-C5, a member of the tumor necrosis factor receptor family.
  
  
  METHODS
  TRAF1-C5 gene polymorphisms, rs2900180 and rs3761847, were analysed in 120 Caucasian PBCs. The HRQoL was assessed with SF-36, PBC-40, and PBC-27 questionnaires.
  
  
  RESULTS
  We found a negative association between TT genotype of rs2900180 and SF-36's domains vitality (P < 0.05), mental health (P < 0.05), and mental component summary score (P < 0.05). GG homozygotes of rs3761847 had lower vitality (P < 0.05), mental health (P < 0.05), mental component summary score (P < 0.05) and impairment of social functioning (P < 0.01). Allelic analysis has shown that T allele of rs2900180 and G allele of rs3761847 related to SF-36's vitality (P < 0.05 and P < 0.01), social functioning (P < 0.05 and P < 0.05), mental health (P < 0.01 and P < 0.05), and mental component summary score (P < 0.01 and P < 0.05), respectively. Genotyping and allelic analysis did not reveal correlation with PBC-40 and PBC-27 domains.
  
  
  CONCLUSIONS
  The association between rs2900180 and rs3761847 polymorphisms and HRQoL variables indicates that TRAF1 is involved in the induction of impaired QoL in PBC.
authors.affiliation: Liver Research Laboratories, Pomeranian Medical University, Aleja Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Raszeja-Wyszomirska
authors.forename: Ewa
authors.initials: E
authors.lastname: Wunsch
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kempinska-Podhorodecka
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Smyk
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Bogdanos
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Milkiewicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Milkiewicz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D007398:Interpersonal Relations; D008105:Liver Cirrhosis, Biliary / Q000208:ethnology / Q000235:genetics* / Q000276:immunology / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires; D047990:TNF Receptor-Associated Factor 1 / Q000235:genetics*; D044465:White People
chemical_list: D047990:TNF Receptor-Associated Factor 1