title: EDTA-dependent pseudothrombocytopenia complicated by eosinophilic pneumonia.
abstract: EDTA-dependent pseudothrombocytopenia (EDTA-PTCP) is a phenomenon that occurs in vitro when EDTA reacts with harvested blood. EDTA-dependent pseudothrombocytopenia usually does not indicate thrombocytopenia in vivo. Here, we report the first case of EDTA-PTCP complicated by eosinophilic pneumonia. A 70-year-old man with rectal cancer was admitted to the hospital for a liver abscess and rectal cancer. At the time of admission, his platelet count was 20,000/μL, but a peripheral blood smear showed platelet aggregation and the platelet count for a kanamycin-added EDTA blood sample was 180,000/μL. The patient's respiratory status worsened after treatment for the liver abscess and rectal cancer. The patient's bronchoalveolar lavage contained 45% eosinophils, and a diagnosis of acute eosinophilic pneumonia was made. In recent studies, the occurrence of eosinophilic disease has been shown in idiopathic thrombocytopenic purpura. EDTA-dependent pseudothrombocytopenia is an in vitro phenomenon, although platelet activation that results in eosinophil invasion may occur in severe cases.
authors.affiliation: Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Ohashi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Nakamura
authors.forename: Ryota
authors.initials: R
authors.lastname: Inokuchi
authors.forename: Hajime
authors.initials: H
authors.lastname: Sato
authors.forename: Kurato
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Tatsuma
authors.initials: T
authors.lastname: Fukuda
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakajima
authors.forename: Naoki
authors.initials: N
authors.lastname: Yahagi
mesh_terms: D000368:Aged; D000925:Anticoagulants; D001780:Blood Coagulation Tests; D004492:Edetic Acid; D006801:Humans; D008297:Male; D011657:Pulmonary Eosinophilia / Q000150:complications / Q000175:diagnosis*; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications / Q000175:diagnosis*
chemical_list: D000925:Anticoagulants; D004492:Edetic Acid