title: Glucocorticoids in adult cardiac surgery; old drugs revisited.
abstract: Glucocorticoids can play a pivotal role in modulating different immune responses. The role of glucocorticoids in cardiac surgery is still controversial as many surgeons are concerned about the potential side effects. In this review, we looked at the role of glucocorticoid administration in modulating postoperative inflammatory responses, atrial fibrillation (AF) and intimal hyperplasia and whether glucocorticoid use is associated with a significant increase in undesirable postoperative complication.
authors.affiliation: Department of Cardiothoracic Surgery, St. George's Hospital, London, UK. marta.koertzen@imperial.nhs.uk
authors.forename: M
authors.initials: M
authors.lastname: Zakkar
authors.forename: R
authors.initials: R
authors.lastname: Kanagasabay
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000379:methods; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D006965:Hyperplasia / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology / Q000473:pathology; D011183:Postoperative Complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D017539:Tunica Intima / Q000187:drug effects / Q000276:immunology / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids
keywords: atrial fibrillation; glucocorticoids; inflammation; intimal hyperplasia