title: Efficacy and safety of local anaesthetics for premature ejaculation: a systematic review and meta-analysis.
abstract: To assess the efficacy and safety of local anaesthetics for premature ejaculation (PE), a systematic review of the literature was performed using the Cochrane Library, PUBMED and EMBASE. We screened and retrieved the randomized controlled trials on the treatment of PE with local anaesthetics. End points included intravaginal ejaculation latency time (IELT), patient-reported outcome assessments and adverse events. Meta-analyses were conducted with Stata 11.0. In total, seven publications involving 566 patients with local anaesthetics and 388 with placebos strictly met our eligibility criteria. Meta-analyses showed that after the patients were treated with the local anaesthetics, the value of the standardized mean difference of the changes in IELT was 5.02 (95% CI: 3.03-7.00). A higher rate of adverse events occurred compared with placebos (odds ratio: 3.30, 95% CI: 1.71-6.36), but these events were restricted to local side effects. In addition, significantly greater improvement was observed in patient-reported outcomes. In summary, local anaesthetics can prolong IELT and improve ejaculatory control and sexual satisfaction.
authors.affiliation: Division of Andrology, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing 210008, China.
authors.forename: Jia-Dong
authors.initials: JD
authors.lastname: Xia
authors.forename: You-Feng
authors.initials: YF
authors.lastname: Han
authors.forename: Liu-Hua
authors.initials: LH
authors.lastname: Zhou
authors.forename: Yun
authors.initials: Y
authors.lastname: Chen
authors.forename: Yu-Tian
authors.initials: YT
authors.lastname: Dai
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D008297:Male; D061686:Premature Ejaculation / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000779:Anesthetics, Local