title: Prognosticators and the relationship of depression and quality of life in head and neck cancer.
abstract: OBJECTIVE
  To evaluate the relationship of emotional status and health-related quality of life (HRQOL) in disease-free head and neck cancer (HNC) patients post treatment and to explore their predictive factors.
  
  
  METHODS
  Seventy-three HNC patients, post treatment at least 1 year, were recruited to complete three questionnaires, EORTC QLQ-C30, EORTC-H&N35 cancer module, and the Beck Depression Inventory-II (BDI-II).
  
  
  RESULTS
  Patients with depression demonstrated significantly poor global health status/QoL (score 41.7 vs. 71.9, P<0.001) and almost all functioning, except for role functioning. Besides, depressive patients presented statistically significant worse symptoms in all QLQ-C30 items, except constipation and financial problems, and in all QLQ-H&N35 symptoms except for teeth and coughing problems. Depression was significantly negative correlated with all functional scales and global health status/QoL (r = -0.341 to -0.750, all P<0.05), and was significantly positive correlated with symptom scales (r = 0.348 to 0.793, all P<0.05), except for constipation. Stepwise multiple linear regression analyses showed that physical functioning and physical distressful symptoms play an important role in the perception of HRQOL (total 46% explained). Global health status and impaired social functioning could explain depression in addition to emotional functioning (total 64% explained).
  
  
  CONCLUSIONS
  HNC patients with depression were noted to have poorer HRQOL in almost every functioning symptom. HNC patients may get benefit from early interventions to improve HRQOL, emotional status, or both by a more rapid and friendly questionnaire to earlier identify patients with poor HRQOL or depressive status.
authors.affiliation: School of Medicine, Tzu Chi University, Hualien, Taiwan.
authors.forename: W Y
authors.initials: WY
authors.lastname: Chiou
authors.forename: M S
authors.initials: MS
authors.lastname: Lee
authors.forename: H C
authors.initials: HC
authors.lastname: Ho
authors.forename: S K
authors.initials: SK
authors.lastname: Hung
authors.forename: H Y
authors.initials: HY
authors.lastname: Lin
authors.forename: Y C
authors.initials: YC
authors.lastname: Su
authors.forename: C C
authors.initials: CC
authors.lastname: Lee
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D003863:Depression / Q000175:diagnosis* / Q000453:epidemiology; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000523:psychology*; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011788:Quality of Life; D011795:Surveys and Questionnaires