title: Structure-based studies of chemokine receptors.
abstract: Chemokine receptors, which belong to the G protein-coupled receptor (GPCR) family of proteins, are critical regulators of cell migration in the context of immune surveillance, inflammation, and development. Recently determined structures of chemokine receptor CXCR4 reveal unique structural features, and offer templates for homology modeling of other chemokine receptors, which deepen our understanding in ligand-binding modes and signal transduction mechanisms. Dimerization, another intriguing issue for GPCR research, is also reviewed based on all published GPCR structures.
authors.affiliation: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Haike Road 501, Pudong District, 201203 Shanghai, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Zhu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.forename: Beili
authors.initials: B
authors.lastname: Wu
mesh_terms: D001665:Binding Sites; D002465:Cell Movement; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D019281:Dimerization; D057166:High-Throughput Screening Assays; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D019718:Receptors, CXCR4 / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure
chemical_list: C527276:CXCR4 protein, human; D008024:Ligands; D019718:Receptors, CXCR4