title: [Evaluation on preparation process of brevisapin colon-specific tables and its in vitro release].
abstract: OBJECTIVE
  To prepare the new traditional Chinese medicine preparation--pH-dependent brevisapin colon-specific tablets, and investigate its in vitro release, in order to discuss the feasibility of preparing colon-targeted traditional Chinese medicines.
  
  
  METHODS
  With scutellarin, the active ingredient in brevisapin, as the evaluation index, coating prescriptions of the preparation was screened. The in vitro release determination method was adopted to detect the in vitro release performance of the preparation.
  
  
  RESULTS
  The in vitro release determination results showed no brevisapin in artificial pH 1. 2 dilute hydrochloric acid solution for 2 h, an accumulated dissolution rate of less than 5% in pH 6. 8 phosphate buffer solution for 4 h, but an accumulated dissolution rate exceeding 90% in pH 7. 6 phosphate buffer solution for 1 h.
  
  
  CONCLUSIONS
  Brevisapin colon-specific tablets prepared can realize colon-specific release.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. yanlingli18@163.com
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Li
authors.forename: Jin-Yu
authors.initials: JY
authors.lastname: Wang
authors.forename: De-Bin
authors.initials: DB
authors.lastname: Yang
authors.forename: Mei-Hong
authors.initials: MH
authors.lastname: Dong
authors.forename: Yan
authors.initials: Y
authors.lastname: Tong
mesh_terms: D000284:Administration, Oral; D047310:Apigenin / Q000008:administration & dosage / Q000737:chemistry*; D002021:Buffers; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003106:Colon; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D005965:Glucuronates / Q000008:administration & dosage / Q000737:chemistry*; D006851:Hydrochloric Acid / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009928:Organ Specificity; D012995:Solubility; D013607:Tablets
chemical_list: D002021:Buffers; D004365:Drugs, Chinese Herbal; D005965:Glucuronates; D013607:Tablets; C484876:scutellarin; D047310:Apigenin; D006851:Hydrochloric Acid