title: "Head-to-side-chain" cyclodepsipeptides of marine origin.
abstract: Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as "head-to-side-chain" cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond between the C-terminus and a β-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. This structural pattern, the presence of unique and complex residues, and relevant bioactivity are the main features shared by all the members of this new class of depsipeptides, which are reviewed herein.
authors.affiliation: Institute for Research in Biomedicine, Baldiri Reixac 10, Barcelona 08028, Spain. marta.pelay@irbbarcelona.org
authors.forename: Marta
authors.initials: M
authors.lastname: Pelay-Gimeno
authors.forename: Judit
authors.initials: J
authors.lastname: Tulla-Puche
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry*; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D047630:Depsipeptides; D005227:Fatty Acids; D061065:Polyketides