title: Systems virology: host-directed approaches to viral pathogenesis and drug targeting.
abstract: High-throughput molecular profiling and computational biology are changing the face of virology, providing a new appreciation of the importance of the host in viral pathogenesis and offering unprecedented opportunities for better diagnostics, therapeutics and vaccines. Here, we provide a snapshot of the evolution of systems virology, from global gene expression profiling and signatures of disease outcome, to geometry-based computational methods that promise to yield novel therapeutic targets, personalized medicine and a deeper understanding of how viruses cause disease. To realize these goals, pipettes and Petri dishes need to join forces with the powers of mathematics and computational biology.
authors.affiliation: Department of Microbiology and Washington National Primate Research Center, University of Washington, Box 358070, Seattle, Washington 98195, USA.
authors.forename: G Lynn
authors.initials: GL
authors.lastname: Law
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Korth
authors.forename: Arndt G
authors.initials: AG
authors.lastname: Benecke
authors.forename: Michael G
authors.initials: MG
authors.lastname: Katze
mesh_terms: D000818:Animals; D019295:Computational Biology; D016503:Drug Delivery Systems / Q000379:methods*; D057166:High-Throughput Screening Assays / Q000379:methods; D054884:Host-Pathogen Interactions; D006801:Humans; D049490:Systems Biology / Q000379:methods*; D014773:Virology / Q000379:methods*; D014774:Virulence; D014777:Virus Diseases / Q000188:drug therapy* / Q000821:virology*; D014780:Viruses / Q000472:pathogenicity