title: Cranofacial osteosarcoma: Single institutional experience in Korea.
abstract: BACKGROUND
  Craniofacial osteosarcoma is a rare disease accounting for only 1% of all head and neck malignancies. Its clinical features and optimal treatments are not yet clearly established.
  
  
  METHODS
  We retrospectively analyzed the clinical course of 15 patients with craniofacial osteosarcoma treated in a single institute.
  
  
  RESULTS
  Out of 13 patients who initially underwent primary mass resection, disease recurrence was found in five (36%). Patients with positive surgical margins showed higher recurrence and shorter median recurrence-free and overall survival. Of three patients who had secondary operation after local recurrence, two survived for 44.6 and 64.2 months, respectively. One patient who underwent repeated lung metastasectomy had a disease-free survival of 18.4 months from the first recurrence.
  
  
  CONCLUSIONS
  The current study demonstrates that positive surgical margins are important predictive factors for recurrence and overall survival. Salvage surgery for local recurrence and metastasectomy for systemic recurrence might have a positive impact on survival.
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Seungtaek
authors.initials: S
authors.lastname: Lim
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Soohyeon
authors.initials: S
authors.lastname: Lee
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Rha
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jae Kyung
authors.initials: JK
authors.lastname: Rho
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005147:Facial Bones / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012516:Osteosarcoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D056910:Republic of Korea; D012189:Retrospective Studies; D012886:Skull / Q000473:pathology; D055815:Young Adult
keywords: head and neck neoplasm; metastasectomy; prognosis; recurrence; sarcoma