title: Long non-coding RNA: a new player in cancer.
abstract: Emerging evidence showed that long non-coding RNAs (lncRNAs) play important roles in a wide range of biological processes and dysregulated lncRNAs are involved in many complex human diseases, including cancer. Although a few lncRNAs' functions in cancer have been characterized, the detailed regulatory mechanisms of majority of lncRNAs in cancer initiation and progression remain largely unknown. In this review, we summarized recent progress on the mechanisms and functions of lncRNAs in cancer, especially focusing on the oncogenic and tumor suppressive roles of the newly identified lncRNAs, and the pathways these novel molecules might be involved in. Their potentials as biomarkers for diagnosis and prognosis in cancer are also discussed in this paper.
authors.affiliation: China-America Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan 523808, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Chen
authors.forename: Xinxin
authors.initials: X
authors.lastname: Wang
authors.forename: Zunnan
authors.initials: Z
authors.lastname: Huang
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: He
authors.forename: Yueqin
authors.initials: Y
authors.lastname: Chen
mesh_terms: D017398:Alternative Splicing; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D062085:RNA, Long Noncoding