title: Seizure control after subtotal lesional resection.
abstract: Reports on seizure outcomes following surgery for lesional epilepsy consistently cite extent of resection as a significant predictor of outcome. Unfortunately, gross-total resection is not technically feasible in all cases of medically refractory tumor-associated epilepsy. Here, the authors present the case of a 4-year-old girl whose epilepsy was medically controlled after 1-stage electrocorticography-guided subtotal resection (STR) of a large diffuse protoplasmic astrocytoma. They also review the modern literature on epilepsy associated with brain tumors. Outcomes are compared with those following surgical treatment of focal cortical dysplasia and vascular lesions. Gross-total lesional resection shows significant superiority across pathologies and anatomical regions. Despite a considerable number of STRs yielding seizure freedom, other favorable treatment factors have not been defined. Although gross-total lesional resection, if possible, is clearly superior, tailored surgery may still offer patients a significant opportunity for a good outcome. Treatment factors yielding successful seizure control following STR remain to be fully elucidated.
authors.affiliation: Division of Pediatric Neurosurgery, Norton Neuroscience Institute, 210 East Gray Street, Louisville, KY 40202, USA. william.gump@nortonhealthcare.org
authors.forename: William C
authors.initials: WC
authors.lastname: Gump
authors.forename: Karen L
authors.initials: KL
authors.lastname: Skjei
authors.forename: Shefali N
authors.initials: SN
authors.lastname: Karkare
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D001254:Astrocytoma / Q000601:surgery; D001932:Brain Neoplasms / Q000601:surgery; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D049268:Positron-Emission Tomography; D011183:Postoperative Complications / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants