title: Renal insufficiency in IBD--prevalence and possible pathogenetic aspects.
abstract: OBJECTIVE
  Extraintestinal manifestations of parenchymatous organs like kidney are rarely noticed in Inflammatory Bowel Disease (IBD). The aim of this study was to investigate the prevalence of renal insufficiency (RI) in IBD and look for potential causative factors and pathogenetic aspects.
  
  
  METHODS
  The study consists of two parts; the first determined the prevalence of RI in IBD and the second possible causative factors. For the first part all patients with IBD who had been investigated at our institution in the period from March 2006 to December 2007 were included. For the second part 25 IBD patients with RI were matched with 50 IBD patients without RI. To determine causative factors several gastroenterologic and renal parameters were compared between these two groups.
  
  
  RESULTS
  Eleven out of 775 patients with IBD had RI, all of them suffering from Crohn's disease (CD). This led to a prevalence of 1.99% for patients with CD and of 0% for patients with ulcerative colitis (UC). Concerning IBD risk factors only duration of disease (p=0.002) and length of resected small bowel (p=0.004) had a significant impact. Two nephrologic parameters, recurrent urolithiasis and the number of interventions due to kidney stones, were risk factors for the development of RI (p=0.03).
  
  
  CONCLUSIONS
  RI is a rare (2%) but relevant complication in CD, not found in UC. Extensive small bowel resection and recurrent urolithiasis seem to be the major causative factors.
authors.affiliation: Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Austria. Electronic address: christian.primas@meduniwien.ac.at.
authors.forename: Christian
authors.initials: C
authors.lastname: Primas
authors.forename: Gottfried
authors.initials: G
authors.lastname: Novacek
authors.forename: Karin
authors.initials: K
authors.lastname: Schweiger
authors.forename: Andreas
authors.initials: A
authors.lastname: Mayer
authors.forename: Alexander
authors.initials: A
authors.lastname: Eser
authors.forename: Pavol
authors.initials: P
authors.lastname: Papay
authors.forename: Cornelia
authors.initials: C
authors.lastname: Gratzer
authors.forename: Sieglinde
authors.initials: S
authors.lastname: Angelberger
authors.forename: Clemens
authors.initials: C
authors.lastname: Dejaco
authors.forename: Walter
authors.initials: W
authors.lastname: Reinisch
authors.forename: Harald
authors.initials: H
authors.lastname: Vogelsang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001806:Blood Urea Nitrogen; D003093:Colitis, Ulcerative / Q000097:blood / Q000453:epidemiology* / Q000601:surgery; D003404:Creatinine / Q000097:blood; D003424:Crohn Disease / Q000097:blood / Q000453:epidemiology* / Q000601:surgery; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000601:surgery; D007669:Kidney Calculi / Q000453:epidemiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012008:Recurrence; D051437:Renal Insufficiency / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D013997:Time Factors
chemical_list: D003404:Creatinine
keywords: Crohn's disease; IBD; Nephrolithiasis; Renal insufficiency; Ulcerative colitis