title: [Fish by-products oil corrects dyslipidemia, improves reverse cholesterol transport and stimulates paraoxonase-1 activity in obese rat].
abstract: OBJECTIVE
  To valorize fish by-products oil by investigating its effects on dyslipidemia, hyperglycemia, reverse cholesterol transport and paraoxonase-1 activity in obese rat.
  
  
  METHODS
  Sixteen male Wistar rats were fed a high fat diet. At 400 ± 10 g, obese rats were randomly divided into two groups: the first received 20% of sardine by-products oil and the second 20% of the edible portion oil. At d28, glycemia and serum lipids concentrations were estimated. High density lipoproteins (HDL2 and HDL3) were separated and their contents and composition in lipids and apolipoproteins were analyzed. Lecithin: cholesterol acyltransferase and paraoxonase-1 activities were assessed.
  
  
  RESULTS
  In group which consumed sardine by-products oil, serum cholesterol and triacylglycerols were reduced (-8% and -36%, respectively). However, glycemia was similar. HDL3-phospholipids, HDL3-unesterified cholesterol and HDL3-apolipoproteins were decreased by 56%, 10% and 12%, respectively. Lecithin: cholesterol acyltransferase activity was increased by 35% and the content of HDL2-cholesteryl esters was elevated by 12%. Serum paraoxonase-1 activity was increased by 25%.
  
  
  CONCLUSIONS
  In obese rat, sardine by-products oil may have a protective effect against cardiovascular risk by improving the anti-atherogenic metabolic pathway of cholesterol and triacylglycerols. This anti-atherogenic action is particularly enhanced by the increase in paraoxonase-1 activity which protects lipoproteins from oxidation.
authors.affiliation: Laboratoire de nutrition clinique et métabolique (LNCM), faculté des sciences, département de biologie, université d'Oran, BP 1524, El M'Nouer, 31100 Oran, Algérie.
authors.forename: N
authors.initials: N
authors.lastname: Boukhari
authors.forename: D
authors.initials: D
authors.lastname: Taleb-Senouci
authors.forename: F Z
authors.initials: FZ
authors.lastname: Chabane
authors.forename: M
authors.initials: M
authors.lastname: Besbes
authors.forename: M Y
authors.initials: MY
authors.lastname: Lamri-Senhadji
mesh_terms: D000818:Animals; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000097:blood* / Q000188:drug therapy*; D005395:Fish Oils / Q000008:administration & dosage*; D006949:Hyperlipidemias / Q000097:blood; D054709:Lecithins / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood* / Q000188:drug therapy*; D009821:Oils / Q000008:administration & dosage; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D002785:Sterol O-Acyltransferase / Q000097:blood; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D005395:Fish Oils; D054709:Lecithins; D009821:Oils; D014280:Triglycerides; D002784:Cholesterol; D002785:Sterol O-Acyltransferase; D043303:Aryldialkylphosphatase
keywords: By-products; Co-produits; Fish; Huile; LCAT; Obesity; Obésité; Oil; Paraoxonase-1; Poisson; Rat