title: Pulmonary toxicity screening of triclosan in rats after intratracheal instillation.
abstract: Triclosan (TCS) is a chemical compound used in household products as biocide. However, their pulmonary toxicity has been unclear. Thus, the purpose of this study was to investigate the possibility of injury to the lung by inhalation of TCS. Rats were exposed to TCS by single intratracheal instillation of 10 µg/B.W. kg for the low-dose group and 1,000 µg/B.W. kg for the high-dose group, respectively. TCS induced increase in the level of total cell (TC) count, polymorphonuclear leukocytes (PMNs), total protein (TP), lactate acid dehydrogenase (LDH), tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in bronchoalveolar lavage fluid (BALF) at 1 day after instillation. However, most pulmonary toxicity marker levels except TP in BALF were restored 14 days after instillation. In addition, TCS led to reduction of cell viability with morphological change in lung eptiehelial cells (L2 cell). Therefore, TCS may affect responses of acute inflammation and permeability in the lung.
authors.affiliation: Environmental Health Research Department, National Institute of Environmental Research, Incheon, Korea.
authors.forename: Jung-Taek
authors.initials: JT
authors.lastname: Kwon
authors.forename: Young-Su
authors.initials: YS
authors.lastname: Yang
authors.forename: Min-Sung
authors.initials: MS
authors.lastname: Kang
authors.forename: Gyun-Baek
authors.initials: GB
authors.lastname: Seo
authors.forename: Dong Hun
authors.initials: DH
authors.lastname: Lee
authors.forename: Mi-Jin
authors.initials: MJ
authors.lastname: Yang
authors.forename: Ilseob
authors.initials: I
authors.lastname: Shim
authors.forename: Hyun-Mi
authors.initials: HM
authors.lastname: Kim
authors.forename: Pilje
authors.initials: P
authors.lastname: Kim
authors.forename: Kyunghee
authors.initials: K
authors.lastname: Choi
authors.forename: Kyuhong
authors.initials: K
authors.lastname: Lee
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D002463:Cell Membrane Permeability; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology; D006795:Household Products; D007322:Instillation, Drug; D008168:Lung / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014132:Trachea; D014260:Triclosan / Q000008:administration & dosage* / Q000378:metabolism / Q000633:toxicity*
chemical_list: D014260:Triclosan