title: Growth and differentiation effects of Homer3 on a leukemia cell line.
abstract: The Homer protein family, also known as the family of cytoplasmic scaffolding proteins, which include three subtypes (Homer1, Homer2, Homer3). Homer3 can regulate transcription and play a very important role in the differentiation and development for some tissues (e.g. muscle and nervous systems). The current studies showed that Homer3 abnormal expression changes in acute myeloid leukemia (AML). Forced expression of Homer3 in transfected K562 cells inhibited proliferation, influenced the cell cycle profile, affected apoptosis induced by As2O3 through inhibition of Bcl2 expression, and also promoted cell differentiation induced by 12-O-tetra decanoylphorbol-acetate (TPA). These results showed that Homer3 is a novel gene which plays a certain role in the occurrence and development of AML.
authors.affiliation: Leukemia Research Division, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of the Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Qiu
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiao
authors.forename: Jian-Nong
authors.initials: JN
authors.lastname: Cen
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Fu
authors.forename: Shao-Yan
authors.initials: SY
authors.lastname: Hu
authors.forename: Ming-Qing
authors.initials: MQ
authors.lastname: Zhu
authors.forename: De-Pei
authors.initials: DP
authors.lastname: Wu
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Qi
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000494:pharmacology; D015153:Blotting, Western; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D005434:Flow Cytometry; D015972:Gene Expression Regulation, Neoplastic; D000072233:Homer Scaffolding Proteins; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D010087:Oxides / Q000494:pharmacology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D001152:Arsenicals; D002352:Carrier Proteins; C000606614:HOMER1 protein, human; C000606616:HOMER3 protein, human; D000072233:Homer Scaffolding Proteins; D010087:Oxides; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D000077237:Arsenic Trioxide