title: Role of microRNAs in the immune system, inflammation and cancer.
abstract: MicroRNAs, a key class of gene expression regulators, have emerged as crucial players in various biological processes such as cellular proliferation and differentiation, development and apoptosis. In addition, microRNAs are coming to light as crucial regulators of innate and adaptive immune responses, and their abnormal expression and/or function in the immune system have been linked to multiple human diseases including inflammatory disorders, such as inflammatory bowel disease, and cancers. In this review, we discuss our current understanding of microRNAs with a focus on their role and mode of action in regulating the immune system during inflammation and carcinogenesis.
authors.affiliation: University of Auvergne, 63000 Clermont-Ferrand, France.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Raisch
authors.forename: Arlette
authors.initials: A
authors.lastname: Darfeuille-Michaud
authors.forename: Hang Thi Thu
authors.initials: HT
authors.lastname: Nguyen
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D041981:Gastrointestinal Tract / Q000276:immunology / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000378:metabolism*; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D035683:MicroRNAs / Q000378:metabolism*; D011379:Prognosis
chemical_list: D035683:MicroRNAs
keywords: Colorectal cancer; Immune response; Inflammation; Inflammatory bowel disease; MicroRNAs