title: Resting-state fMRI in the Human Connectome Project.
abstract: Resting-state functional magnetic resonance imaging (rfMRI) allows one to study functional connectivity in the brain by acquiring fMRI data while subjects lie inactive in the MRI scanner, and taking advantage of the fact that functionally related brain regions spontaneously co-activate. rfMRI is one of the two primary data modalities being acquired for the Human Connectome Project (the other being diffusion MRI). A key objective is to generate a detailed in vivo mapping of functional connectivity in a large cohort of healthy adults (over 1000 subjects), and to make these datasets freely available for use by the neuroimaging community. In each subject we acquire a total of 1h of whole-brain rfMRI data at 3 T, with a spatial resolution of 2×2×2 mm and a temporal resolution of 0.7s, capitalizing on recent developments in slice-accelerated echo-planar imaging. We will also scan a subset of the cohort at higher field strength and resolution. In this paper we outline the work behind, and rationale for, decisions taken regarding the rfMRI data acquisition protocol and pre-processing pipelines, and present some initial results showing data quality and example functional connectivity analyses.
authors.affiliation: FMRIB (Oxford Centre for Functional MRI of the Brain), Oxford University, Oxford, UK. steve@fmrib.ox.ac.uk
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Smith
authors.forename: Christian F
authors.initials: CF
authors.lastname: Beckmann
authors.forename: Jesper
authors.initials: J
authors.lastname: Andersson
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Auerbach
authors.forename: Janine
authors.initials: J
authors.lastname: Bijsterbosch
authors.forename: Gwenaëlle
authors.initials: G
authors.lastname: Douaud
authors.forename: Eugene
authors.initials: E
authors.lastname: Duff
authors.forename: David A
authors.initials: DA
authors.lastname: Feinberg
authors.forename: Ludovica
authors.initials: L
authors.lastname: Griffanti
authors.forename: Michael P
authors.initials: MP
authors.lastname: Harms
authors.forename: Michael
authors.initials: M
authors.lastname: Kelly
authors.forename: Timothy
authors.initials: T
authors.lastname: Laumann
authors.forename: Karla L
authors.initials: KL
authors.lastname: Miller
authors.forename: Steen
authors.initials: S
authors.lastname: Moeller
authors.forename: Steve
authors.initials: S
authors.lastname: Petersen
authors.forename: Jonathan
authors.initials: J
authors.lastname: Power
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Salimi-Khorshidi
authors.forename: Abraham Z
authors.initials: AZ
authors.lastname: Snyder
authors.forename: An T
authors.initials: AT
authors.lastname: Vu
authors.forename: Mark W
authors.initials: MW
authors.lastname: Woolrich
authors.forename: Junqian
authors.initials: J
authors.lastname: Xu
authors.forename: Essa
authors.initials: E
authors.lastname: Yacoub
authors.forename: Kamil
authors.initials: K
authors.lastname: Uğurbil
authors.forename: David C
authors.initials: DC
authors.lastname: Van Essen
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Glasser
mesh_terms: D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D063132:Connectome / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008953:Models, Anatomic; D008959:Models, Neurological; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology; D012146:Rest / Q000502:physiology*