title: Long-term health experience of jet engine manufacturing workers: VIII. glioblastoma incidence in relation to workplace experiences with parts and processes.
abstract: OBJECTIVE
  To determine whether glioblastoma (GB) incidence rates among jet engine manufacturing workers were associated with workplace experiences with specific parts produced and processes performed.
  
  
  METHODS
  Subjects were 210,784 workers employed between 1952 and 2001. We conducted nested case-control and cohort incidence studies with focus on 277 GB cases. We estimated time experienced with 16 part families, 4 process categories, and 32 concurrent part-process combinations with 20 or more GB cases.
  
  
  RESULTS
  In both the cohort and case-control studies, none of the part families, process categories, or both considered was associated with increased GB risk.
  
  
  CONCLUSIONS
  If not due to chance alone, the not statistically significantly elevated GB rates in the North Haven plant may reflect external occupational factors or nonoccupational factors unmeasured in the current evaluation.
authors.affiliation: Center for Occupational Biostatistics and Epidemiology, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. gmarsh@pitt.edu
authors.forename: Gary M
authors.initials: GM
authors.lastname: Marsh
authors.forename: Ada O
authors.initials: AO
authors.lastname: Youk
authors.forename: Jeanine M
authors.initials: JM
authors.lastname: Buchanich
authors.forename: Sarah
authors.initials: S
authors.lastname: Downing
authors.forename: Kathleen J
authors.initials: KJ
authors.lastname: Kennedy
authors.forename: Nurtan A
authors.initials: NA
authors.lastname: Esmen
authors.forename: Roger P
authors.initials: RP
authors.lastname: Hancock
authors.forename: Steven E
authors.initials: SE
authors.lastname: Lacey
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Pierce
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Fleissner
mesh_terms: D000401:Aircraft; D016022:Case-Control Studies; D016543:Central Nervous System Neoplasms / Q000453:epidemiology*; D015331:Cohort Studies; D003237:Connecticut / Q000453:epidemiology; D005909:Glioblastoma / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007221:Industry / Q000379:methods*; D008420:Manufactured Materials / Q000706:statistics & numerical data*; D009784:Occupational Diseases / Q000453:epidemiology*; D012307:Risk Factors; D013997:Time Factors