title: [Glycosylated hemoglobin A1c for the diagnosis of diabetes mellitus: a meta-analysis].
abstract: OBJECTIVE
  To assess the diagnostic value of glycosylated hemoglobin A1c (HbA1c) ≥ 6.5% for diabetes in Chinese adults with oral glucose tolerance test (OGTT) as the reference standard.
  
  
  METHODS
  Major databases were searched to get all diagnostic tests with HbA1c ≥ 6.5% for diabetes in Chinese adults. QUADAS items were used to evaluate the quality of the eligible studies. Meta-disc software was used to perform comprehensive quantitative assessment for all included studies and summary ROC (SROC) curve were drawn.
  
  
  RESULTS
  A total of 11 studies were included. The outcomes of the diagnostic value with HbA1c ≥ 6.5% were as the following: pooled sensitivity 0.62 (95%CI: 0.60 - 0.64), pooled specificity 0.96 (95%CI: 0.95 - 0.96), diagnostic odds ratio (DOR) 40.25 (95%CI: 20.79 - 77.95) and AUCSROC 0.7702 (sx = 0.0636).
  
  
  CONCLUSIONS
  The diagnostic specificity is pretty high for the diagnostic test with HbA1c ≥ 6.5%, while sensitivity is low. Combination of HbA1c and glucose tests is needed to reduce the missed diagnosis rate.
authors.affiliation: Department of Endocrinology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Song-tao
authors.initials: ST
authors.lastname: Tang
authors.forename: Qiu
authors.initials: Q
authors.lastname: Zhang
authors.forename: Chang-jiang
authors.initials: CJ
authors.lastname: Wang
authors.forename: Hai-qin
authors.initials: HQ
authors.lastname: Tang
authors.forename: Tai-xiang
authors.initials: TX
authors.lastname: Wu
mesh_terms: D044466:Asian People; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis*; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D006442:Glycated Hemoglobin