title: Radioimmunotherapy for high-grade glioma.
abstract: Patients with high-grade glioma (HGG) still have a very poor prognosis. The infiltrative nature of the tumor and the inter- and intra-tumoral cellular and genetic heterogeneity, leading to the acquisition of new mutations over time, represent the main causes of treatment failure. Radioimmunotherapy represents an emerging approach for the treatment of HGG. Radioimmunotherapy utilizes a molecular vehicle (monoclonal antibodies) to deliver a radionuclide (the drug) to a selected cell population target. This review will provide an overview of preclinical and clinical studies to date and assess the effectiveness of radioimmunotherapy, focusing on possible future therapies for the treatment of HGG.
authors.affiliation: Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy. debonisvox@gmail.com
authors.forename: Pasquale
authors.initials: P
authors.lastname: De Bonis
authors.forename: Giorgio
authors.initials: G
authors.lastname: Lofrese
authors.forename: Carmelo
authors.initials: C
authors.lastname: Anile
authors.forename: Angelo
authors.initials: A
authors.lastname: Pompucci
authors.forename: Vera
authors.initials: V
authors.lastname: Vigo
authors.forename: Annunziato
authors.initials: A
authors.lastname: Mangiola
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005910:Glioma / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D058990:Molecular Targeted Therapy; D016499:Radioimmunotherapy / Q000379:methods*; D011868:Radioisotopes / Q000627:therapeutic use*
chemical_list: D000911:Antibodies, Monoclonal; D011868:Radioisotopes