title: [Oral rush desensitization for cow milk allergy: Clinical and immunological follow-up].
abstract: OBJECTIVE
  The aim of this study was to evaluate the safety and efficacy of oral rush desensitization in children with cow milk allergy.
  
  
  METHODS
  Prospective study. We included IgE-mediated cow milk allergy children over 3 years in 3 Spanish hospitals. Increasing doses of cow milk for 5 days from 1 cc of 1% to 200 cc of pure milk were administered. Clinical follow-up was conducted and we compared specific IgE levels at onset, 6, 12 and 24 months after desensitization.
  
  
  RESULTS
  We included 18 children (13 males) between 3 and 14 years (mean 5.96). A total of 271 doses were administered; there were 55 adverse reactions (84% mild). At the end of the protocol, 100% showed some degree of tolerance (39% total). Full tolerance was achieved in 72% of patients after two years. Two children failed to achieve tolerance. There was a significant decrease in the levels of specific IgE to cow milk and alpha-lactalbumin at 24 months, and to casein at 6, 12 and 24 months, compared to baseline.
  
  
  CONCLUSIONS
  Oral rush desensitization is a safe and effective therapeutic option for patients with persistent cow milk allergy to medium term.
authors.affiliation: Gastroenterología y Nutrición Pediátrica, Área de Gestión Clínica de Pediatría, Hospital Central de Asturias, Oviedo, España. Electronic address: domixixon@gmail.com.
authors.forename: D
authors.initials: D
authors.lastname: González Jiménez
authors.forename: E
authors.initials: E
authors.lastname: Larrea Tamayo
authors.forename: J J
authors.initials: JJ
authors.lastname: Díaz Martin
authors.forename: C
authors.initials: C
authors.lastname: Molinos Norniella
authors.forename: D
authors.initials: D
authors.lastname: Pérez Solis
authors.forename: C
authors.initials: C
authors.lastname: Menéndez Arias
authors.forename: S
authors.initials: S
authors.lastname: Jiménez Treviño
authors.forename: C
authors.initials: C
authors.lastname: Bousoño García
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D016269:Milk Hypersensitivity / Q000276:immunology* / Q000628:therapy*; D009055:Mouth; D011446:Prospective Studies; D016896:Treatment Outcome
keywords: Alergia a proteínas de leche de vaca; Cow milk allergy; Inducción de tolerancia oral; Oral rush desensitization; Oral tolerance induction; Pauta rush desensibilización oral