title: Retinopathy of prematurity and the oxygen conundrum: lessons learned from recent randomized trials.
abstract: Emerging data from randomised controlled trials of different pulse oximeter oxygen saturation (SpO(2)) target ranges shows that higher SpO(2) targets are associated with a higher risk of severe retinopathy of prematurity. However, the trials have also shown that higher SpO(2) targets are associated with improved survival. In the light of these results and pending the full results for long-term outcome, it is recommended that oxygen saturation targets for preterm infants of gestational age less than 28 weeks at birth should be maintained at or more than 90%.
authors.affiliation: Department of Ophthalmology, Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh, EH3 9HA, UK. Brian.Fleck@ed.ac.uk
authors.forename: Brian W
authors.initials: BW
authors.lastname: Fleck
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Stenson
mesh_terms: D049673:History, 20th Century; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D010100:Oxygen / Q000008:administration & dosage* / Q000009:adverse effects / Q000266:history; D016032:Randomized Controlled Trials as Topic; D012178:Retinopathy of Prematurity / Q000097:blood / Q000266:history / Q000517:prevention & control*
chemical_list: D010100:Oxygen