title: Prospects for oral replicating adenovirus-vectored vaccines.
abstract: Orally delivered replicating adenovirus (Ad) vaccines have been used for decades to prevent adenovirus serotype 4 and 7 respiratory illness in military recruits, demonstrating exemplary safety and high efficacy. That experience suggests that oral administration of live recombinant Ads (rAds) holds promise for immunization against other infectious diseases, including those that have been refractory to traditional vaccination methods. Live rAds can express intact antigens from free-standing transgenes during replication in infected cells. Alternatively, antigenic epitopes can be displayed on the rAd capsid itself, allowing presentation of the epitope to the immune system both prior to and during replication of the virus. Such capsid-display rAds offer a novel vaccine approach that could be used either independently of or in combination with transgene expression strategies to provide a new tool in the search for protection from infectious disease.
authors.affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, United States.
authors.forename: Cailin
authors.initials: C
authors.lastname: Deal
authors.forename: Andrew
authors.initials: A
authors.lastname: Pekosz
authors.forename: Gary
authors.initials: G
authors.lastname: Ketner
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D000284:Administration, Oral; D000818:Animals; D000941:Antigens / Q000235:genetics / Q000276:immunology; D002213:Capsid / Q000276:immunology*; D036022:Capsid Proteins / Q000276:immunology; D002986:Clinical Trials as Topic; D000939:Epitopes / Q000276:immunology; D005822:Genetic Vectors; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D019076:Transgenes; D014612:Vaccines / Q000235:genetics / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology; D014779:Virus Replication
chemical_list: D000941:Antigens; D036022:Capsid Proteins; D000939:Epitopes; D014612:Vaccines; D014614:Vaccines, Synthetic; C018315:hexon capsid protein, Adenovirus