title: Metabolic syndrome and endothelial dysfunction in a population born small for gestational age relationship to growth and Gh therapy.
abstract: Being born small for gestational age (SGA) and a rapid increase in weight during early childhood and infancy have been strongly linked to metabolic syndrome. A transversal study was conducted on 167 pre-pubertal and 102 pubertal subjects; auxological parameters, systolic and diastolic blood pressure, laboratory data, and carotid-wall thickness (CA-IMT) were measured.
  
  
  RESULTS
  Patients born SGA with spontaneous catch-up growth have higher values of BMI, blood pressure, HOMA index, and CA-IMT than those treated with GH and the appropriate-for-gestational age (AGA) group. In conclusion, subjects born SGA are at high risk of developing chronic diseases, including obesity, hypertension, insulin resistant, and endothelial dysfunction, at an early age, mainly those with good catch-up growth compared with the receiving GH because of negative catch-up growth. Our data is compared with published results.
authors.affiliation: Andrea Prader Foundation, IACS (Instituto de Ciencias de La Salud-Institute of Health Sciences), Government of Aragon.
authors.forename: Antonio
authors.initials: A
authors.lastname: de Arriba
authors.forename: Mercedes
authors.initials: M
authors.lastname: Domínguez
authors.forename: José I
authors.initials: JI
authors.lastname: Labarta
authors.forename: Manuel
authors.initials: M
authors.lastname: Domínguez
authors.forename: Beatriz
authors.initials: B
authors.lastname: Puga
authors.forename: Esteban
authors.initials: E
authors.lastname: Mayayo
authors.forename: Angel Ferrández
authors.initials: AF
authors.lastname: Longás
mesh_terms: D000293:Adolescent; D001724:Birth Weight / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006130:Growth Disorders / Q000150:complications / Q000151:congenital / Q000188:drug therapy* / Q000503:physiopathology*; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000254:growth & development* / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology*; D011247:Pregnancy
chemical_list: D019382:Human Growth Hormone