title: Facilitated temporal processing of pain and defective supraspinal control of pain in cluster headache.
abstract: In cluster headache (CH), pathogenesis has been emphasized the role of the posterior hypothalamus. It is part of a supraspinal network involved in the descending control of pain, including the diffuse noxious inhibitory control (DNIC), which in turn modulates the pain processing. We hypothesized that CH during the active phase facilitated temporal pain processing supported by abnormal functioning of the DNIC. We studied the functional activity of the DNIC by evaluating the effect of the cold pressor test (CPT) on the temporal summation threshold (TST) of the nociceptive withdrawal reflex. Ten subjects with episodic CH (2 women, 8 men) and 10 healthy subjects were recruited. Each subject underwent neurophysiological evaluation (nociceptive withdrawal reflex TST and related painful sensation) at baseline, then before (control session), during (pain session), and 5 min after (aftereffect) the CPT (immersing hand in a 4°C water bath for 4-5 min). Patients had been studied during both the active and remission phases. During the active phase, CH revealed a significant facilitation in temporal processing of pain stimuli (reduction of TST), which reverted during the remission phase. The CPT activating the DNIC did not produce any significant inhibitory effect of pain responses in CH during the active phase, whereas it induced a clear inhibition during the remission phase. We hypothesized that in CH, a dysfunction of the supraspinal control of pain related to the clinical activity of the disease, possibly supported by an abnormal hypothalamic function, leads to a facilitation in pain processing and a predisposition to pain attacks.
authors.affiliation: Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy. arm.perrotta@gmail.com
authors.forename: Armando
authors.initials: A
authors.lastname: Perrotta
authors.forename: Mariano
authors.initials: M
authors.lastname: Serrao
authors.forename: Anna
authors.initials: A
authors.lastname: Ambrosini
authors.forename: Monica
authors.initials: M
authors.lastname: Bolla
authors.forename: Gianluca
authors.initials: G
authors.lastname: Coppola
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sandrini
authors.forename: Francesco
authors.initials: F
authors.lastname: Pierelli
mesh_terms: D000293:Adolescent; D000328:Adult; D003027:Cluster Headache / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000175:diagnosis / Q000209:etiology*; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology*; D011312:Pressure / Q000009:adverse effects; D011601:Psychophysics; D018709:Statistics, Nonparametric; D055815:Young Adult