title: [Acquired hemophilia presenting as gross hematuria and perineal subcutaneous hemorrhage after prostate biopsy: a case report].
abstract: Acquired hemophilia is a rare disease that can result in life threatening bleeding associated with coagulation factor VIII inhibitors. A 61-year-old man presented gross hematuria and urinary retention. A retrograde pyelography, cystoscopy, abdominal computed tomography and prostate biopsy showed no finding suggestive of malignancy. Extensive subcutaneous hemorrhage over the perineal region and severe hematuria were observed after the prostate biopsy. Further hematological evaluation showed the presence of coagulation factor VIII inhibitors, which led to the diagnosis of acquired hemophilia. All symptoms disappeared without complication after administration of predonisolone and recombinant activated factor VII.
authors.affiliation: The Department of Urology, Kansai Electric Power Hospital.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kimura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Uegaki
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Aoyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nagai
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hashimura
mesh_terms: D001706:Biopsy / Q000009:adverse effects*; D003937:Diagnosis, Differential; D006417:Hematuria / Q000175:diagnosis / Q000209:etiology*; D006467:Hemophilia A / Q000175:diagnosis*; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*