title: Synthesis of indolines via Pd(II)-catalyzed amination of C-H bonds using PhI(OAc)2 as the bystanding oxidant.
abstract: The Pd(II)-catalyzed intramolecular C-H amination of 2-pyridinesulfonyl-protected phenethylamine derivatives has been achieved using PhI(OAc)2 as a bystanding oxidant, providing access to a variety of substituted indoline derivatives in good yields. The use of the 2-pyridinesulfonyl protecting group allows for facile deprotection following C-H functionalization.
authors.affiliation: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors.forename: Tian-Sheng
authors.initials: TS
authors.lastname: Mei
authors.forename: Dasheng
authors.initials: D
authors.lastname: Leow
authors.forename: Han
authors.initials: H
authors.lastname: Xiao
authors.forename: Brian N
authors.initials: BN
authors.lastname: Laforteza
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D000586:Amination; D002384:Catalysis; D006860:Hydrogen Bonding; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007462:Iodobenzenes / Q000737:chemistry*; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D007211:Indoles; D007462:Iodobenzenes; D016877:Oxidants; D010165:Palladium; C057812:indoline