title: Novel methodologic approaches to phase I, II, and III trials.
authors.affiliation: Department of Public Health Sciences, Medical University of South Carolina, 135 Cannon St, Charleston, SC 29425, USA. yeatts@musc.edu
authors.forename: Sharon D
authors.initials: SD
authors.lastname: Yeatts
mesh_terms: D017321:Clinical Trials, Phase I as Topic / Q000639:trends*; D017322:Clinical Trials, Phase II as Topic / Q000639:trends*; D017326:Clinical Trials, Phase III as Topic / Q000639:trends*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D018447:Medical Futility; D012107:Research Design / Q000639:trends*; D020521:Stroke / Q000188:drug therapy / Q000628:therapy*; D016896:Treatment Outcome
keywords: adaptive design; clinical trial design; continual reassessment method; futility design; selection design