title: Insights into the Transforming Growth Factor-β Signaling Pathway in Cutaneous Melanoma.
abstract: Transforming growth factor-β (TGF-β) is a pleiotropic growth factor with broad tissue distribution that plays critical roles during embryonic development, normal tissue homeostasis, and cancer. While its cytostatic activity on normal epithelial cells initially defined TGF-β signaling as a tumor suppressor pathway, there is ample evidence indicating that TGF-β is a potent pro-tumorigenic agent, acting via autocrine and paracrine mechanisms to promote peri-tumoral angiogenesis, together with tumor cell migration, immune escape, and dissemination to metastatic sites. This review summarizes the current knowledge on the implication of TGF-β signaling in melanoma.
authors.affiliation: Institut Curie, Team "TGF-β and Oncogenesis", Equipe Labellisée Ligue Contre le Cancer, Orsay, France. ; INSERM U1021 Orsay, France. ; CNRS UMR 3347, Orsay, France.
authors.forename: Carole Yolande
authors.initials: CY
authors.lastname: Perrot
authors.forename: Delphine
authors.initials: D
authors.lastname: Javelaud
authors.forename: Alain
authors.initials: A
authors.lastname: Mauviel
keywords: Melanoma; Metastasis; TGF-beta signaling; Therapeutic-targets