title: Rh[III]-catalyzed C-H amidation using aroyloxycarbamates to give N-Boc protected arylamines.
abstract: The Rh(III)-catalyzed amidation of C(sp(2))-H bonds by the use of electron-deficient aroyloxycarbamates as efficient electrophilic amidation partners is reported. The reaction proceeded under mild conditions with broad functional group tolerance, and pyridine and O-methyl hydroxamic acids serve as efficient directing groups, giving access to valuable N-Boc protected arylamines (also Fmoc and Cbz). Preliminary mechanistic experiments are discussed.
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität , Corrensstr. 40, 48149 Münster, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Grohmann
authors.forename: Honggen
authors.initials: H
authors.lastname: Wang
authors.forename: Frank
authors.initials: F
authors.lastname: Glorius
mesh_terms: D000588:Amines / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D002384:Catalysis; D005563:Formic Acid Esters / Q000737:chemistry*; D006877:Hydroxamic Acids / Q000737:chemistry*; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000588:Amines; D002219:Carbamates; D005563:Formic Acid Esters; D006877:Hydroxamic Acids; C000345:t-butyloxycarbonyl group; D012238:Rhodium