title: [Inflammasome--essential regulator of the inflammatory reaction].
abstract: The function of inflammasome in the cell is to sense intracellular danger signals and--perhaps as the last cry of distress of a cell invaded by a microorganism--at an emergency situation to release interleukins (IL) outside of the cell, causing an inflammatory reaction and fever and also leads to an elevation of CRP. In a hopeless situation inflammasome-regulated pyroptosis is started. Disturbed action of inflammasomes has been linked to the pathogenesis of various disorders such as gout, atherosclerosis, asbestosis and type 2 diabetes. As the pathogenetic mechanisms of such diseases become clear, improved treatments for them may also become available.
authors.affiliation: VACTIA-Tutkimuslaboratorio, Tampereen Yilopisto, Lääketieteen Yksikkö FIMLAB OY, Klininen Mikrobiologia.
authors.forename: Ilkka
authors.initials: I
authors.lastname: Junttila
authors.forename: Seppo
authors.initials: S
authors.lastname: Meri
authors.forename: Mika
authors.initials: M
authors.lastname: Rämet
mesh_terms: D017209:Apoptosis / Q000276:immunology; D001195:Asbestosis / Q000276:immunology; D050197:Atherosclerosis / Q000276:immunology; D002097:C-Reactive Protein / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology; D005334:Fever / Q000276:immunology; D006073:Gout / Q000276:immunology; D006801:Humans; D058847:Inflammasomes / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D007378:Interleukins / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D058847:Inflammasomes; D007378:Interleukins; D002097:C-Reactive Protein