title: Acetylation of retinoblastoma like protein2 (Rb2/p130) in tumor tissues.
abstract: The activity of Rb proteins is controlled by post-translational modifications, especially through phosphorylation. Acetylation of Rb2/p130 was reported recently in NIH3T3 cells but its physiological relevance in cell cycle control and tumorigenesis is still unknown. Efforts are underway to investigate possible interplay between Rb2/p130 phosphorylation and acetylation. Here we hypothesized that Rb2/p130 acetylation, like p53 acetylation, may play a role in development of the tumor phenotype. The proposed hypothesis regarding acetylation of Rb2/p130 in tumor VS normal cells was found to be true in our case study of 36 tumor samples. Statistical analysis of results suggest strong correlation among Rb2/p130 acetylation and cancer phenotype.
authors.affiliation: Department of Biosciences, COMSATS Institute of Information Technology (CIIT), Islamabad, Pakistan.
authors.forename: Z N
authors.initials: ZN
authors.lastname: Khan
authors.forename: M
authors.initials: M
authors.lastname: Sabir
authors.forename: M A
authors.initials: MA
authors.lastname: Kayani
authors.forename: M
authors.initials: M
authors.lastname: Saeed
mesh_terms: D000107:Acetylation; D016022:Case-Control Studies; D005500:Follow-Up Studies; D006801:Humans; D047468:Immunoprecipitation; D060787:Neoplasm Grading; D011379:Prognosis; D011499:Protein Processing, Post-Translational; D012175:Retinoblastoma / Q000378:metabolism* / Q000473:pathology*; D050717:Retinoblastoma-Like Protein p130 / Q000378:metabolism*
chemical_list: D050717:Retinoblastoma-Like Protein p130