title: Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume.
abstract: Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275 Centre National de la Recherche Scientifique (CNRS), Valbonne, France.
authors.forename: Grégory
authors.initials: G
authors.lastname: Conductier
authors.forename: Frédéric
authors.initials: F
authors.lastname: Brau
authors.forename: Angèle
authors.initials: A
authors.lastname: Viola
authors.forename: Fanny
authors.initials: F
authors.lastname: Langlet
authors.forename: Navean
authors.initials: N
authors.lastname: Ramkumar
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Dehouck
authors.forename: Thibault
authors.initials: T
authors.lastname: Lemaire
authors.forename: Raphaël
authors.initials: R
authors.lastname: Chapot
authors.forename: Laurianne
authors.initials: L
authors.lastname: Lucas
authors.forename: Carole
authors.initials: C
authors.lastname: Rovère
authors.forename: Priscilla
authors.initials: P
authors.lastname: Maitre
authors.forename: Salma
authors.initials: S
authors.lastname: Hosseiny
authors.forename: Agnès
authors.initials: A
authors.lastname: Petit-Paitel
authors.forename: Antoine
authors.initials: A
authors.lastname: Adamantidis
authors.forename: Bernard
authors.initials: B
authors.lastname: Lakaye
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Risold
authors.forename: Vincent
authors.initials: V
authors.lastname: Prévot
authors.forename: Olivier
authors.initials: O
authors.lastname: Meste
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Nahon
authors.forename: Alice
authors.initials: A
authors.lastname: Guyon
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000166:cytology; D002118:Calcium / Q000378:metabolism; D002552:Cerebral Ventricles / Q000033:anatomy & histology* / Q000187:drug effects; D002555:Cerebrospinal Fluid / Q000187:drug effects / Q000378:metabolism; D002923:Cilia / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D004805:Ependyma / Q000033:anatomy & histology*; D005260:Female; D006727:Hormone Antagonists / Q000494:pharmacology; D007028:Hypothalamic Hormones / Q000172:deficiency / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008543:Melanins / Q000172:deficiency / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010907:Pituitary Hormones / Q000172:deficiency / Q000494:pharmacology*; D017481:Receptors, Somatostatin / Q000172:deficiency / Q000235:genetics; D012701:Serotonin / Q000494:pharmacology
chemical_list: D006727:Hormone Antagonists; D007028:Hypothalamic Hormones; C491209:Mchr1 protein, mouse; D008543:Melanins; D009419:Nerve Tissue Proteins; D010907:Pituitary Hormones; D017481:Receptors, Somatostatin; D012701:Serotonin; C019463:melanin-concentrating hormone; D000255:Adenosine Triphosphate; D002118:Calcium