title: Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin-globotriose hybrids.
abstract: Designed and synthesized porphyrin-globotriose hybrids effectively degraded verotoxin-1, which causes severe bloody diarrhoea and fetal hemolytic uremic syndrome (HUS). Degradation was achieved using long-wavelength UV or visible light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrids neutralized the cytotoxicity of verotoxin upon photo-irradiation.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Okochi
authors.forename: Shuho
authors.initials: S
authors.lastname: Tanimoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takahashi
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Toshima
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D008027:Light; D010782:Photolysis; D011166:Porphyrins / Q000737:chemistry*; D022622:Shiga Toxin 1 / Q000378:metabolism* / Q000633:toxicity; D014312:Trisaccharides / Q000737:chemistry*; D014466:Ultraviolet Rays; D014709:Vero Cells
chemical_list: D011166:Porphyrins; D022622:Shiga Toxin 1; D014312:Trisaccharides; C113460:globotriose