title: [Chemical constituents from Hydrangea macrophylla].
abstract: OBJECTIVE
  To investigate chemical constituents from Chinese herbal medicine Hydrangea macrophylla.
  
  
  METHODS
  The compounds were separated and purified by column chromatography over silica gel, ODS, and preparative HPLC. Their structures were identified by spectral methods including 1H, 13C-NMR and MS.
  
  
  RESULTS
  Eleven compounds were isolated and identified as zeorin, hopane-6, 22-diol (1), botulin (2), betulinic acid (3), 2-ethyl-3-methyl-maleimide-N-beta-D-glucopyranoside (4), uridine (5), thymidine (6), adenosine (7), nicotinamide (8), methyl pyroglutamate (9), hydrangenol (10) and hydrangenol-4'-O-beta-D-glucopyranoside (11), respectively.
  
  
  CONCLUSIONS
  Compounds 14 and 7-9 were obtained from the genus Hydrangea for the first time.
authors.affiliation: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material Bases, Harbin 150040, China.
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Wang
authors.forename: Jiang-Tao
authors.initials: JT
authors.lastname: Guo
authors.forename: Chun-Juan
authors.initials: CJ
authors.lastname: Yang
authors.forename: Yong-Hai
authors.initials: YH
authors.lastname: Meng
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Wang
authors.forename: Bing-You
authors.initials: BY
authors.lastname: Yang
authors.forename: Hai-Xue
authors.initials: HX
authors.lastname: Kuang
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification*; D035264:Flowers / Q000737:chemistry; D031966:Hydrangea / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal