title: Norfloxacin drug induces reproductive toxicity and alters androgen receptor gene expression in testes and cloacal gland of male Japanese quail (Coturnix Japonica).
abstract: In an attempt to investigate the reproductive toxicity of norfloxacin in Japanese quail, male quail were given norfloxacin at 20 mg/kg body weight for 14 d. Then reproductive function and androgen receptor (AR) gene expression was examined in treated and control birds. The results of the present study indicate that fertility, cloacal gland area, sperm concentration, and serum testosterone were reduced significantly (p < 0.05) on day 14 in the norfloxacin-treated birds. Upregulation (p < 0.05) of AR mRNA was also seen in the testes on the 14th d of treatment. A trend toward downregulation of AR mRNA was seen in the cloacal gland of norfloxacin-treated birds. Histological observations revealed that norfloxacin induces cellular atrophy in testes and changes in glandular tissue in the cloacal gland. The results of the present study demonstrate that norfloxacin induces testicular toxicity in Japanese quail.
authors.affiliation: Avian Physiology and Genetics Division, Sálim Ali Centre for Ornithology and Natural History, Coimbatore, India. rampratapsingh81@gmail.com
authors.forename: Ram P
authors.initials: RP
authors.lastname: Singh
authors.forename: Kochiganti V H
authors.initials: KV
authors.lastname: Sastry
authors.forename: Pawan K
authors.initials: PK
authors.lastname: Dubey
authors.forename: Radha
authors.initials: R
authors.lastname: Agrawal
authors.forename: Renu
authors.initials: R
authors.lastname: Singh
authors.forename: Nitin Kumar
authors.initials: NK
authors.lastname: Pandey
authors.forename: Jag
authors.initials: J
authors.lastname: Mohan
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D002988:Cloaca / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003370:Coturnix / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005298:Fertility / Q000187:drug effects; D008297:Male; D009643:Norfloxacin / Q000633:toxicity*; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism*; D012098:Reproduction / Q000187:drug effects*; D013076:Sperm Count; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013739:Testosterone / Q000097:blood
chemical_list: D000900:Anti-Bacterial Agents; D011944:Receptors, Androgen; D013739:Testosterone; D009643:Norfloxacin
keywords: Androgen receptor; Fertility; Reproductive toxicity