title: Synthesis of novel bis(pyrimido[5,4-c]quinoline-2,4(1H,3H)-dione) and its derivatives: evaluation of their antioxidant properties.
abstract: One pot cyclocondensation reaction of barbituric/thiobarbituric acid with aromatic aldehydes and p-phenylenediamine/2,6-diaminopyridine by refluxing in glacial acetic acid afforded novel bis(pyrimido[5,4-c]quinoline-2,4(1H,3H)-diones)/pyrido bis(pyrimido[5,4-c]quinoline-2,4(1H,3H)-diones. All the synthesized compounds were screened for their antioxidant activities using FRAP and DPPH methods. Compounds with chloro substituents showed relatively good antioxidant properties.
authors.affiliation: Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem 636 011, Tamil Nadu, India.
authors.forename: Kandasamy
authors.initials: K
authors.lastname: Parameswaran
authors.forename: Paramasivam
authors.initials: P
authors.lastname: Sivaguru
authors.forename: Appaswami
authors.initials: A
authors.lastname: Lalitha
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D003500:Cyclization; D005290:Ferric Compounds / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010851:Picrates / Q000138:chemical synthesis / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D005290:Ferric Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D011743:Pyrimidines; D011804:Quinolines; C585542:bis(pyrimido(5,4-c)quinoline-2,4(1H,3H)-dione); C004931:1,1-diphenyl-2-picrylhydrazyl