title: miRNA in the regulation of ion channel/transporter expression.
abstract: Ion channels and transporters are expressed in every living cell, where they participate in controlling a plethora of biological processes and physiological functions, such as excitation of cells in response to stimulation, electrical activities of cells, excitation-contraction coupling, cellular osmolarity, and even cell growth and death. Alterations of ion channels/transporters can have profound impacts on the cellular physiology associated with these proteins. Expression of ion channels/transporters is tightly regulated and expression deregulation can trigger abnormal processes, leading to pathogenesis, the channelopathies. While transcription factors play a critical role in controlling the transcriptome of ion channels/transporters at the transcriptional level by acting on the 5'-flanking region of the genes, microribonucleic acids (miRNAs), a newly discovered class of regulators in the gene network, are also crucial for expression regulation at the posttranscriptional level through binding to the 3'untranslated region of the genes. These small noncoding RNAs fine tune expression of genes involved in a wide variety of cellular processes. Recent studies revealed the role of miRNAs in regulating expression of ion channels/transporters and the associated physiological functions. miRNAs can target ion channel genes to alter cardiac excitability (conduction, repolarization, and automaticity) and affect arrhythmogenic potential of heart. They can modulate circadian rhythm, pain threshold, neuroadaptation to alcohol, brain edema, etc., through targeting ion channel genes in the neuronal systems. miRNAs can also control cell growth and tumorigenesis by acting on the relevant ion channel genes. Future studies are expected to rapidly increase to unravel a new repertoire of ion channels/transporters for miRNA regulation.
authors.affiliation: Harbin Medical University, Harbin, Heilongjiang, People's Republic of China. wz.email@gmail.com
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D006321:Heart / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D035683:MicroRNAs / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics; D034622:RNA Interference; D012160:Retina / Q000502:physiology
chemical_list: D007473:Ion Channels; D035683:MicroRNAs