title: Adoptive T-cell transfer for refractory viral infections with cytomegalovirus, Epstein-Barr virus or adenovirus after allogeneic stem cell transplantation.
abstract: Viral infections after allogeneic stem cell transplantation (SCT) are an important cause of morbidity and mortality as SCT can expose patients to a transient state of combined immunodeficieny. Most viral infections after SCT are caused by the endogenous reactivation of persistent pathogens such as adenovirus (ADV), cytomegalovirus (CMV), and Epstein-Barr-virus (EBV). The control of these infections will ultimately depend on the restoration of adequate T-cell immunity.
authors.affiliation: Pediatric Hematology/Oncology, University Children's Hospital Tübingen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Feucht
authors.forename: L
authors.initials: L
authors.lastname: Joachim
authors.forename: P
authors.initials: P
authors.lastname: Lang
authors.forename: T
authors.initials: T
authors.lastname: Feuchtinger
mesh_terms: D000257:Adenoviridae Infections / Q000276:immunology* / Q000628:therapy*; D019264:Adoptive Transfer; D002648:Child; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000628:therapy*; D020031:Epstein-Barr Virus Infections / Q000276:immunology* / Q000628:therapy*; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D009894:Opportunistic Infections / Q000276:immunology* / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology*; D016896:Treatment Outcome