title: Chemokines, chemokine receptors and the gastrointestinal system.
abstract: The biological properties of tumor cells are known to be regulated by a multitude of cytokines and growth factors, which include epidermal growth factor receptor agonists and members of the transforming growth factor β family. Furthermore, the recent explosion of research in the field of chemokine function as mediators of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches. In this review, we will summarize recently reported findings in chemokine biology with a focus on the gastrointestinal tract.
authors.affiliation: Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA. hmiyazaki@vcu.edu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyazaki
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Takabe
authors.forename: W Andrew
authors.initials: WA
authors.lastname: Yeudall
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000473:pathology; D018925:Chemokines / Q000378:metabolism*; D004064:Digestive System / Q000276:immunology* / Q000473:pathology; D004067:Digestive System Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D019707:Receptors, Chemokine / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine
keywords: Cancer; Chemokine; Digestive system; Receptor; Signal transduction; Targeted therapeutics; Tumor progression