title: Optimisation of a generic ionic model of cardiac myocyte electrical activity.
abstract: A generic cardiomyocyte ionic model, whose complexity lies between a simple phenomenological formulation and a biophysically detailed ionic membrane current description, is presented. The model provides a user-defined number of ionic currents, employing two-gate Hodgkin-Huxley type kinetics. Its generic nature allows accurate reconstruction of action potential waveforms recorded experimentally from a range of cardiac myocytes. Using a multiobjective optimisation approach, the generic ionic model was optimised to accurately reproduce multiple action potential waveforms recorded from central and peripheral sinoatrial nodes and right atrial and left atrial myocytes from rabbit cardiac tissue preparations, under different electrical stimulus protocols and pharmacological conditions. When fitted simultaneously to multiple datasets, the time course of several physiologically realistic ionic currents could be reconstructed. Model behaviours tend to be well identified when extra experimental information is incorporated into the optimisation.
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia. t.guo@unsw.edu.au
authors.forename: Tianruo
authors.initials: T
authors.lastname: Guo
authors.forename: Amr
authors.initials: A
authors.lastname: Al Abed
authors.forename: Nigel H
authors.initials: NH
authors.lastname: Lovell
authors.forename: Socrates
authors.initials: S
authors.lastname: Dokos
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000465:Algorithms; D000818:Animals; D016275:Atrial Function / Q000502:physiology; D019295:Computational Biology; D003198:Computer Simulation; D055724:Electrophysiological Phenomena; D007473:Ion Channels / Q000502:physiology; D017136:Ion Transport / Q000502:physiology; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology*; D011817:Rabbits; D012849:Sinoatrial Node / Q000502:physiology
chemical_list: D007473:Ion Channels