title: The manifestation of cocaine-induced midline destructive lesion in bone tissue and its identification in human skeletal remains.
abstract: Cocaine-induced midline destructive lesion (CIMDL) is a condition that may arise in response to chronic insufflation ("snorting") of cocaine. It is clinically diagnosed when the nasal septum, lateral nasal walls, and/or hard palate show signs of destruction in association with cocaine use. Although its true incidence is unknown, CIMDL is not an uncommon clinical finding amongst intranasal cocaine abusers and is likely to be encountered by forensic anthropologists and medical examiners working worldwide. Given the preponderance of drug abusers amongst the subjects of forensic casework, the ability to diagnose CIMDL in dry bone may provide crucial insight into an investigation and even help confirm an individual identification. This paper aims to make practicing forensic anthropologists aware of CIMDL. Through the analysis of existing clinical literature, patient CT scans, and histology sections, it works toward the establishment of formal diagnostic criteria for identifying CIMDL in human skeletal remains. Lytic destruction regularly involves the vomer and frequently extends to the perpendicular plate of the ethmoid, the palatal process of the maxillae or the palatine bones, and the inferior nasal conchae. The middle nasal conchae, medial walls of the maxillary sinuses, ethmoid sinuses, and cribriform plate are often damaged. Destruction may also implicate the superior nasal conchae, the orbit, and the sphenoid. Bones affected by CIMDL may contain necrotic lesions or may be absent entirely. Lesions show minimal, if any, signs of repair. The author proposes that this lack of new bone formation may be mediated by potentially elevated leptin levels in cocaine abusers and CIMDL patients and may be the key to differentiating CIMDL from other lytic processes of the midface.
authors.affiliation: University of Pennsylvania, Department of Anthropology, University Museum, Room 325, 3260 South Street, Philadelphia, PA 19104, USA. krubin@ufl.edu
authors.forename: Katie
authors.initials: K
authors.lastname: Rubin
mesh_terms: D000281:Administration, Intranasal; D019970:Cocaine-Related Disorders / Q000473:pathology*; D004677:Encephalocele / Q000139:chemically induced / Q000473:pathology; D005004:Ethmoid Bone / Q000473:pathology; D018732:Forensic Anthropology; D006801:Humans; D008437:Maxilla / Q000473:pathology; D009300:Nasal Septum / Q000473:pathology; D009915:Orbit / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D010159:Palate / Q000473:pathology; D010256:Paranasal Sinuses / Q000473:pathology
keywords: Bone metabolism; CIMDL; Cocaine; Forensic anthropology; Leptin; Skeletal pathology