title: Is the adipose tissue a key target of developmental programming of adult adiposity by maternal undernutrition?
abstract: Epidemiological studies have shown that maternal undernutrition during pregnancy (MU) leads to intrauterine growth retardation and low birth weight, and may predispose individuals to the development of metabolic syndrome symptoms later in life such as overweight. Some clues from a model of prenatal maternal 70% food-restricted diet throughout gestation in pregnant female rats (FR30) suggest that the white adipose tissue (WAT) is a key target of MU fetal programming. Under standard diet, although showing a lean phenotype, adult FR30 male rats were predisposed to adiposity exhibiting higher serum leptin and corticosterone concentration, two hormones actively involved in WAT regulation. Although FR30 procedure does not worsen the metabolic syndrome features induced by HF diet, FR30HF rats gained more weight and showed hyperleptinemia suggesting increased adiposity. WAT FR30 adult rats revealed marked changes in transcript levels of several genes. In particular, leptin and Ob-Rb, many peptide precursors and receptors, factors involved in lipogenesis and glucocorticoid sensitivity mRNA expression levels as well as mechanisms involved in leptin sensitivity, were modified in FR30 offspring in depot-specific and diet-specific manners. These modifications might predispose for altered fat accumulation in adult male rat offspring.
authors.affiliation: Unité Environnement Périnatal et Croissance; UPRES EA 4489; Université Lille-Nord de France; Equipe Dénutritions Maternelles Périnatales; Villeneuve d'Ascq, France.
authors.forename: Marie-Amélie
authors.initials: MA
authors.lastname: Lukaszewski
authors.forename: Fabien
authors.initials: F
authors.lastname: Delahaye
authors.forename: Didier
authors.initials: D
authors.lastname: Vieau
authors.forename: Christophe
authors.initials: C
authors.lastname: Breton
keywords: adipose tissue; gene expression; high-fat diet; maternal undernutrition; programming