title: Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability.
abstract: Ceftaroline is a new cephalosporin with bactericidal activity against methicillin-resistant S. aureus (MRSA) as well as gram-negative pathogens. Variations of in vitro test conditions were found to affect ceftaroline activity, with 5% NaCl inhibiting growth and/or reducing the minimum inhibitory concentrations (MICs) for E. coli, K. pneumoniae, M. catarrhalis, H. influenzae, and streptococci, while an inoculum of 10(6) CFU/mL raised MICs of some E. coli, K. pneumoniae, and M. catarrhalis strains.
authors.affiliation: R.M. Alden Research Laboratory, Culver City, CA 90230, USA.
authors.forename: Diane M
authors.initials: DM
authors.lastname: Citron
authors.forename: Yumi A
authors.initials: YA
authors.lastname: Warren
authors.forename: Kerin L
authors.initials: KL
authors.lastname: Tyrrell
authors.forename: Ellie J C
authors.initials: EJ
authors.lastname: Goldstein