title: Multifocal bilateral choroidal neovascularization in a patient on ipilimumab for metastatic melanoma.
abstract: Choroidal neovascularization membrane (CNVM) is a significant cause of ocular morbidity. Immunologic mechanisms have been proposed in the development of these lesions in exudative age related macular degeneration. Here, we describe the case of an 81-year-old man receiving ipilimumab, an immune modulating drug that enhances T cell response, for metastatic melanoma who developed three simultaneous CNVM bilaterally. This is the first case of ipilimumab-associated CNVM as well as the first case of an immune modulating drug possibly causing CNVM to our knowledge.
authors.affiliation: Department of Ophthalmology and Vision Science, University of California, Davis, Eye Center, Sacramento, CA, USA.
authors.forename: Bobeck S
authors.initials: BS
authors.lastname: Modjtahedi
authors.forename: Howard
authors.initials: H
authors.lastname: Maibach
authors.forename: Susanna
authors.initials: S
authors.lastname: Park
mesh_terms: D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D020256:Choroidal Neovascularization / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects*; D000074324:Ipilimumab; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology; D012160:Retina / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D007155:Immunologic Factors; D000074324:Ipilimumab