title: [Serum screening of celiac disease in Chinese adults with diarrhea-predominant irritable bowel syndrome in Hubei, China].
abstract: OBJECTIVE
  To screen the prevalence of celiac disease with serologic markers in the central Chinese population, specifically in patients with chronic diarrhea-predominant irritable bowel syndrome (D-IBS).
  
  
  METHODS
  A total of 282 adult patients with D-IBS were selected based on ROME III criteria with 296 age and sex matched consecutive healthy individuals as controls. A gluten-free diet (GFD) was advised in subjects positive for IgA/IgG anti-htTG/DGP antibodies and the serologic antibodies were retested after the GFD.
  
  
  RESULTS
  Among the 578 study subjects, five D-IBS patients (5/282, 1.77%) and two healthy controls (2/296, 0.68%) were positive for anti-htTG/DGP antibodies. Among the seven positive cases, one was lost to follow-up and only four were evaluated during GFD therapy for an average of 5.2 months with clinical and/or serological manifestations improved.
  
  
  CONCLUSIONS
  The prevalence of celiac disease may not be uncommon in China. Compared with the healthy population, patients with D-IBS tend to be affected more. Thus, it is significantly important to conduct routine screening for celiac disease in patients with D-IBS.
authors.affiliation: Department of Gastroenterology, Zhongnan Hospital of Wuhan University School of Medicine, Wuhan, China.
authors.forename: Hong-ling
authors.initials: HL
authors.lastname: Wang
authors.forename: Lin-jie
authors.initials: LJ
authors.lastname: Luo
authors.forename: Ji-guang
authors.initials: JG
authors.lastname: Kou
authors.forename: An-long
authors.initials: AL
authors.lastname: Yuan
authors.forename: Gui-fang
authors.initials: GF
authors.lastname: Yang
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Xia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000097:blood; D002446:Celiac Disease / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000097:blood / Q000150:complications*; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000906:Antibodies