title: Regulatory role of adrenergic neurotransmitters on the spontaneous muscular activity in the ruminant trematode Paramphistomum cervi (Paramphistomatidae).
abstract: The neuromuscular system of helminths is an important area for target identification and drug development. Many anthelmintics, namely ivermectin, levamisole, piperazine, pyrantel, praziquantel and organophosphates, produce paralysis of helminths by affecting their neuromuscular systems. The neuromuscular system of helminths is also an important area of research to identify some of the important differences between the neuromuscular physiology of helminths and mammals. The identification of differences would help in developing newer target-specific, safe and effective anthelmintics. The present study was carried out to investigate the effects of different adrenergic neurotransmitters (epinephrine, norepinephrine, dopamine, l-dopa) and their antagonists (propranolol and haloperidol) on the spontaneous muscular activity of isometrically mounted Paramphistomum cervi.
authors.affiliation: Department of Veterinary Pharmacology and Toxicology,College of Veterinary Science, Assam Agricultural University,Khanapara,Guwahati781022,India.
authors.forename: B
authors.initials: B
authors.lastname: Saikia
authors.affiliation: Department of Veterinary Pharmacology and Toxicology,College of Veterinary Science, Assam Agricultural University,Khanapara,Guwahati781022,India.
authors.forename: C C
authors.initials: CC
authors.lastname: Barua
authors.affiliation: Department of Veterinary Pharmacology and Toxicology,College of Veterinary Science, Assam Agricultural University,Khanapara,Guwahati781022,India.
authors.forename: S
authors.initials: S
authors.lastname: Hazarika
authors.affiliation: Department of Veterinary Pharmacology and Toxicology,College of Veterinary Science, Assam Agricultural University,Khanapara,Guwahati781022,India.
authors.forename: L C
authors.initials: LC
authors.lastname: Lahon
authors.affiliation: Department of Animal Biotechnology,College of Veterinary Science, Assam Agricultural University,Khanapara,Guwahati781022,India.
authors.forename: D
authors.initials: D
authors.lastname: Saikia
authors.affiliation: Department of Livestock Production and Management,College of Veterinary Science, Assam Agricultural University,Khanapara,Guwahati781022,India.
authors.forename: R S
authors.initials: RS
authors.lastname: Borah
authors.affiliation: Department of Veterinary Pharmacology and Toxicology,College of Veterinary Science and Animal Husbandry,SKAUST, R.S. Pura,Jammu,India.
authors.forename: P K
authors.initials: PK
authors.lastname: Verma
mesh_terms: D018663:Adrenergic Agents / Q000378:metabolism*; D000319:Adrenergic beta-Antagonists / Q000378:metabolism*; D000818:Animals; D018492:Dopamine Antagonists / Q000378:metabolism*; D008124:Locomotion; D009132:Muscles / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010250:Paramphistomatidae / Q000502:physiology*
chemical_list: D018663:Adrenergic Agents; D000319:Adrenergic beta-Antagonists; D018492:Dopamine Antagonists; D018377:Neurotransmitter Agents