title: Novel Influenza A (H1N1)-Associated Acute Necrotizing Encephalopathy: A Case Report.
abstract: Several cases of acute necrotizing encephalopathy (ANE) with influenza A (H1N1) have been reported to date. The prognosis of ANE associated with H1N1 is variable; some cases resulted in severe neurologic complication, whereas other cases were fatal. Reports mostly focused on the diagnosis of ANE with H1N1 infection, rather than functional recovery. We report a case of ANE with H1N1 infection in a 4-year-old Korean girl who rapidly developed fever, seizure, and altered mentality, as well as had neurologic sequelae of ataxia, intentional tremor, strabismus, and dysarthria. Brain magnetic resonance imaging showed lesions in the bilateral thalami, pons, and left basal ganglia. To our knowledge, this is the first report of ANE caused by H1N1 infection and its long-term functional recovery in Korea.
authors.affiliation: Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Ki Jung
authors.initials: KJ
authors.lastname: Kim
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Park
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Chang
authors.forename: Miri
authors.initials: M
authors.lastname: Suh
authors.forename: Dong-Wook
authors.initials: DW
authors.lastname: Rha
keywords: H1N1 subtype influenza A virus; Humans influenza; Viral encephalitis