title: Catalytic asymmetric conjugate addition of Grignard reagents to chromones.
abstract: A highly regio- and enantioselective copper catalysed direct conjugate addition of Grignard reagents to chromones has been developed taking advantage of the reduced reactivity of the resulting magnesium enolates. This methodology tolerates a broad scope of alkyl Grignards including secondary alkyl magnesium reagents as well as functionalised chromones.
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Carlos
authors.initials: C
authors.lastname: Vila
authors.forename: Valentín
authors.initials: V
authors.lastname: Hornillos
authors.forename: Martín
authors.initials: M
authors.lastname: Fañanás-Mastral
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa
mesh_terms: D002384:Catalysis; D002867:Chromones / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002867:Chromones; D007202:Indicators and Reagents; D003300:Copper