title: Frequency of endometriosis and adenomyosis in patients with leiomyomas, gynecologic premalignant, and malignant neoplasias.
abstract: OBJECTIVE
  This study investigated the association between gynecological neoplasms, endometriosis, and adenomyosis in women who underwent surgical treatment for gynecological cancer and uterine leiomyoma during reproductive years or after menopause.
  
  
  METHODS
  Information was collected from patient records from the Hospital's database from 1985 to 2007. The study included 502 women, of which 375 were premenopausal and 132 were postmenopausal.
  
  
  RESULTS
  A significant association was observed between the occurrence of adenomyosis in cancer in women with four or more pregnancies, and in women aged over 40 years (p < 0.0001). The frequency of adenomyosis was significantly higher than the frequency of endometriosis for cancer in two sites (p = 0.0419) or for leiomyomas (p < 0.0001).
  
  
  CONCLUSIONS
  Therefore adenomyosis is more frequently found than endometriosis in women with leiomyomas or cancer in two sites in premenopausal women, and clinicians need to be aware of patients with adenomyosis and the risk of cancer.
authors.affiliation: Oncological Research Institute (IPON), Discipline of Gynecology and Obstetrics, Federal University of the Triângulo Mineiro, Uberaba, MG, Brazil.
authors.forename: R S
authors.initials: RS
authors.lastname: Nomelini
authors.forename: F A
authors.initials: FA
authors.lastname: Ferreira
authors.forename: R C
authors.initials: RC
authors.lastname: Borges
authors.forename: S J
authors.initials: SJ
authors.lastname: Adad
authors.forename: E F C
authors.initials: EF
authors.lastname: Murta
mesh_terms: D062788:Adenomyosis / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D015897:Comorbidity; D004715:Endometriosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000453:epidemiology*; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000453:epidemiology*; D055815:Young Adult