title: [Study on efficacy and mechanism of weiyangning pills against experimental gastric ulcer].
abstract: OBJECTIVE
  To study the efficacy and mechanism of Weiyangning pills against experimental gastric ulcer.
  
  
  METHODS
  The gastric ulcer model were established by acetic acid, water-immersion stress, aspirin induction, pyloric ligation in rats, in order to observe the effect of Weiyangning pills against experimental gastric ulcer and study its effect on the content of nitric oxide (NO) and epidermal growth factor (EGF), gastric mucosal blood flow, the content of PGE2, gastric secretion, gastric acid content and the activity of pepsin.
  
  
  RESULTS
  Weiyangning pills markedly reduced index of gastric ulcers of various types, increased the content of NO, EGF, PGE2 and gastric mucosal blood flow, inhibited gastric secretion and gastric acid content, and decreased the activity of pepsin.
  
  
  CONCLUSIONS
  Weiyangning pills has a significant effect against experimental gastric ulcer, which is related to the reduction of gastric mucosa damage factors (gastric acid and pepsin) and the increase in gastric mucosa's function as a barrier and its recovery effects, such as NO, EGF, PGE2 and gastric mucosal blood flow.
authors.affiliation: Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Xu
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
authors.forename: Qing-He
authors.initials: QH
authors.lastname: Wu
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Cao
authors.forename: Si
authors.initials: S
authors.lastname: Wen
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
mesh_terms: D019342:Acetic Acid / Q000009:adverse effects; D000818:Animals; D001241:Aspirin / Q000009:adverse effects; D015232:Dinoprostone / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D004815:Epidermal Growth Factor / Q000378:metabolism; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D008026:Ligation / Q000009:adverse effects; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology
chemical_list: D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide; D004815:Epidermal Growth Factor; D015232:Dinoprostone; D019342:Acetic Acid; D001241:Aspirin