title: [Regulation of cellular responses by non-canonical Wnt signaling].
abstract: Signal transduction, elicited by Wnt-family of secreted proteins, can be classified intoβ-catenin-dependent canonical Wnt signaling and -independent non-canonical Wnt signaling. Non-canonical Wnt signaling contains planar cell polarity (PCP) pathway and Ca (+ +) pathway, which play central roles in developmental morphogenesis, by regulating cellular functions, including cell polarity and cell migration. In this article, we will overview the molecular basis of non-canonical Wnt signaling, with a particular emphasis on the roles of non-canonical Wnt signaling mediated by Wnt5a and its cognate receptors, Ror-family of receptor tyrosine kinases (Ror1, Ror2) , and will introduce up-to-date information on non-canonical Wnt signaling obtained from recent studies about pathological conditions, including cancer progression and chronic inflammation.
authors.affiliation: Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Japan.
authors.forename: Michiru
authors.initials: M
authors.lastname: Nishita
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Endo
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Minami
mesh_terms: D000818:Animals; D016764:Cell Polarity / Q000502:physiology; D006801:Humans; D011956:Receptors, Cell Surface / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000502:physiology*
chemical_list: D011956:Receptors, Cell Surface; D051153:Wnt Proteins