title: Diet influences the intake target and mitochondrial functions of Drosophila melanogaster males.
abstract: In this study, we examine the dietary protein to carbohydrate ratio (P:C) on the mitochondrial functions of two Drosophila melanogaster mtDNA haplotypes. We investigated multiple physiological parameters on flies fed with either 1:12 P:C or 1:3 P:C diets. Our results provide experimental evidence that a specific haplotype has a reduction of complex I activity when the flies are fed with the 1:12 P:C diet. This study is of particular importance to understand the influence of diet on mitochondrial evolution in invasive and broadly distributed species including humans.
authors.affiliation: School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia; Département de Biologie Intégrative, Université du Québec à Rimouski, Rimouski, QC, Canada. Electronic address: pichaud.nicolas@wanadoo.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pichaud
authors.forename: Marie
authors.initials: M
authors.lastname: Messmer
authors.forename: Carolina C
authors.initials: CC
authors.lastname: Correa
authors.forename: J William O
authors.initials: JW
authors.lastname: Ballard
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics; D004032:Diet; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D006239:Haplotypes; D008297:Male; D008928:Mitochondria / Q000502:physiology*
chemical_list: D004272:DNA, Mitochondrial
keywords: Diet; Enzymatic activities; Feeding rate; Haplotype; Mitochondrial functions; P:C ratio