title: Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases.
abstract: Nucleoside analogues have been in clinical use for almost 50 years and have become cornerstones of treatment for patients with cancer or viral infections. The approval of several additional drugs over the past decade demonstrates that this family still possesses strong potential. Here, we review new nucleoside analogues and associated compounds that are currently in preclinical or clinical development for the treatment of cancer and viral infections, and that aim to provide increased response rates and reduced side effects. We also highlight the different approaches used in the development of these drugs and the potential of personalized therapy.
authors.affiliation: Anticancer Antibody Team, Institut National de la Santé et de la Recherche Médicale U1052, Centre National de la Recherche Scientifique UMR 5286, Cancer Research Center of Lyon, Faculté Rockefeller, 8 Ave Rockefeller, 69008 Lyon, France. lars-petter.jordheim@univ-lyon1.fr
authors.forename: Lars Petter
authors.initials: LP
authors.lastname: Jordheim
authors.forename: David
authors.initials: D
authors.lastname: Durantel
authors.forename: Fabien
authors.initials: F
authors.lastname: Zoulim
authors.forename: Charles
authors.initials: C
authors.lastname: Dumontet
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000737:chemistry* / Q000627:therapeutic use; D055808:Drug Discovery / Q000379:methods / Q000639:trends*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D009705:Nucleosides / Q000737:chemistry* / Q000627:therapeutic use; D009711:Nucleotides / Q000737:chemistry* / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D009705:Nucleosides; D009711:Nucleotides