title: Sesame oil attenuates ovalbumin-induced pulmonary edema and bronchial neutrophilic inflammation in mice.
abstract: BACKGROUND
  Allergic asthma is one of the most common chronic inflammatory diseases of airways. Severe asthma may lead to hospitalization and death. Sesame oil is a natural product with anti-inflammatory property. However, the effect of sesame oil on allergic asthma has never been studied.
  
  
  OBJECTIVE
  We investigate the effect of sesame oil on pulmonary inflammation in allergic asthma model.
  
  
  METHODS
  Allergic airway inflammation was induced by sensitizing with two doses of 10 mg ovalbumin (OVA) and then challenged with 1% OVA nebulizer exposure (1 h/day) for 3 days. Sesame oil (0.25, 0.5, or 1 mL/kg/day) was given orally 30 min before each challenge. Samples were collected 24 h after the last challenge.
  
  
  RESULTS
  Data showed that sesame oil inhibited pulmonary edema and decreased interleukin (IL)-1 β and IL-6 levels in bronchoalveolar lavage fluid in OVA-treated mice. Sesame oil also decreased pulmonary nitrite level, inducible nitric oxide synthase expression, and neutrophil infiltration induced by OVA. Further, sesame oil decreased serum IgE level in OVA-treated mice.
  
  
  CONCLUSIONS
  Sesame oil may attenuate pulmonary edema and bronchial neutrophilic inflammation by inhibiting systemic IgE level in allergic asthma.
authors.affiliation: Department of Environmental and Occupational Health, National Cheng Kung University Medical College, 138 Sheng-Li Road, Tainan 70428, Taiwan.
authors.forename: Dur-Zong
authors.initials: DZ
authors.lastname: Hsu
authors.forename: Chuan-Teng
authors.initials: CT
authors.lastname: Liu
authors.forename: Pei-Yi
authors.initials: PY
authors.lastname: Chu
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Li
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Periasamy
authors.forename: Ming-Yie
authors.initials: MY
authors.lastname: Liu
mesh_terms: D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D051379:Mice; D009504:Neutrophils / Q000473:pathology; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D010047:Ovalbumin / Q000008:administration & dosage / Q000633:toxicity; D011014:Pneumonia / Q000188:drug therapy* / Q000473:pathology*; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D012715:Sesame Oil / Q000008:administration & dosage*
chemical_list: D053583:Interleukin-1beta; D015850:Interleukin-6; D012715:Sesame Oil; D010047:Ovalbumin; D052247:Nitric Oxide Synthase Type II