title: Clay: new opportunities for tissue regeneration and biomaterial design.
abstract: Seminal recent studies that have shed new light on the remarkable properties of clay interactions suggest unexplored opportunities for biomaterial design and regenerative medicine. Here, recent conceptual and technological developments in the science of clay interactions with biomolecules, polymers, and cells are examined, focusing on the implications for tissue engineering and regenerative strategies. Pioneering studies demonstrating the utility of clay for drug-delivery and scaffold design are reviewed and areas for future research and development highlighted.
authors.affiliation: Institute of Developmental Sciences University of Southampton Southampton, UK. jid@soton.ac.uk
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Dawson
authors.forename: Richard O C
authors.initials: RO
authors.lastname: Oreffo
mesh_terms: D000538:Aluminum Silicates / Q000138:chemical synthesis*; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D000077215:Clay; D004337:Drug Carriers / Q000138:chemical synthesis*; D004867:Equipment Design / Q000639:trends; D048091:Guided Tissue Regeneration / Q000295:instrumentation* / Q000639:trends; D023822:Tissue Engineering / Q000295:instrumentation* / Q000639:trends; D054457:Tissue Scaffolds / Q000639:trends*
chemical_list: D000538:Aluminum Silicates; D001672:Biocompatible Materials; D004337:Drug Carriers; D000077215:Clay
keywords: clay materials; drug delivery; nanocomposites; nanoparticles; tissue regeneration