title: Changes in IgG subclasses of donor specific anti-HLA antibodies following bortezomib-based therapy for antibody mediated rejection.
abstract: The predominant anti-HLA IgG subclass during antibody mediated rejection episodes is IgG1. Class I DSA IgG subclasses respond to single cycle of bortezomib-based therapy more frequently as compared to Class II DSA IgG subclasses. High titer Class II DSA IgG subclasses are less likely to respond to single cycle bortezomib-based therapy. Future studies are needed to determine if the response to bortezomib-based therapy is dependent on the type of DSA and/or the strength of the DSA at the time of antibody mediated rejection episode.
authors.affiliation: Department of Transplantation Medicine, Weill Cornell Medical College/New York-Presbyterian Hospital, New York, New York, USA.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Kannabhiran
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Everly
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Walker-McDermott
authors.forename: Sue
authors.initials: S
authors.lastname: Tiongko
authors.forename: Rex
authors.initials: R
authors.lastname: Friedlander
authors.forename: Prabhakar
authors.initials: P
authors.lastname: Putheti
authors.forename: Vijay
authors.initials: V
authors.lastname: Sharma
authors.forename: Darshana
authors.initials: D
authors.lastname: Dadhania
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001897:Boronic Acids / Q000627:therapeutic use*; D000069286:Bortezomib; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy* / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation; D010956:Plasmapheresis; D011719:Pyrazines / Q000627:therapeutic use*; D013256:Steroids / Q000627:therapeutic use; D014019:Tissue Donors
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D006680:HLA Antigens; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D011719:Pyrazines; D013256:Steroids; D000069286:Bortezomib