title: The effect of preoperative consumption of potatoes on succinylcholine-induced block and recovery from anesthesia.
abstract: Potatoes contain solanaceous glycoalkaloids (SGAs), which inhibit both butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE). The present study investigated the effect of preoperative consumption of potatoes on succinylcholine-induced block and recovery from anesthesia. ASA I-II, adult patients, scheduled for elective surgery, were included in a randomized, blind and controlled study. Patients were randomly divided into two groups. Patients in Group P (n = 21) ate a standard portion of potatoes in their last meal prior to pre-operative fasting, while patients in Group C (n = 23) ate food not containing SGAs. Patients were premedicated with midazolam. Anesthesia was induced with thiopental and fentanyl, and maintained with sevoflurane in 50 % O2/air and fentanyl, as needed. Succinylcholine 1 mg kg(-1) was administered to facilitate endotracheal intubation. Duration of succinylcholine blockade, awakening and recovery times from anesthesia were measured. Serum BuChE levels were also measured at baseline and 4 time-points within 24 h post-consumption. Duration of succinylcholine-induced neuromuscular block, awakening and recovery time from anesthesia was significantly longer in Group P than in Group C (p < 0.05). Serum BuChE levels decreased at 6 h after consumption start in Group P. In addition, in both groups, BuChE levels markedly decreased after succinylcholine blockade, increased thereafter, but did not return to baseline within 24 h of consumption start. None of these differences observed in BuChE levels was statistically significant. This study suggests that potatoes eaten before anesthesia can prolong the duration of succinylcholine-induced neuromuscular block and delay recovery from anesthesia.
authors.affiliation: Department of Anesthesiology and Reanimation, Firat University School of Medicine, 23119, Elazig, Turkey, abestas@firat.edu.tr.
authors.forename: Azize
authors.initials: A
authors.lastname: Bestas
authors.forename: Hulya
authors.initials: H
authors.lastname: Goksu
authors.forename: Omer Lutfi
authors.initials: OL
authors.lastname: Erhan
mesh_terms: D000759:Adjuvants, Anesthesia / Q000627:therapeutic use; D000328:Adult; D000470:Alkaloids / Q000737:chemistry*; D000758:Anesthesia / Q000379:methods*; D000762:Anesthesia Recovery Period; D018685:Anesthetics, Inhalation / Q000627:therapeutic use; D018686:Anesthetics, Intravenous / Q000627:therapeutic use; D002091:Butyrylcholinesterase / Q000097:blood; D002800:Cholinesterase Inhibitors / Q000737:chemistry; D055191:Delayed Emergence from Anesthesia / Q000209:etiology; D004032:Diet; D005260:Female; D005283:Fentanyl / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000627:therapeutic use; D019148:Neuromuscular Blockade / Q000379:methods*; D009467:Neuromuscular Depolarizing Agents / Q000627:therapeutic use*; D057234:Preoperative Period; D000077149:Sevoflurane; D011198:Solanum tuberosum; D013390:Succinylcholine / Q000627:therapeutic use*; D013874:Thiopental / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000759:Adjuvants, Anesthesia; D000470:Alkaloids; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D002800:Cholinesterase Inhibitors; D008738:Methyl Ethers; D009467:Neuromuscular Depolarizing Agents; D000077149:Sevoflurane; D002091:Butyrylcholinesterase; D013390:Succinylcholine; D013874:Thiopental; D005283:Fentanyl