title: Acute and lasting effects of single mineralocorticoid antagonism on offensive aggressive behaviour in rats.
abstract: Aggression is a major component of territorial behaviour. However, different mechanisms evolved to fulfil the defence function while reducing the cost derived from agonistic interactions, as a differential response to the same stimulus, depending on the outcome of past conflicts - priming, which makes the aggressive response adaptable. Aggressive behaviour is facilitated by the stress response, so, we tested the effect of a single injection of a mineralocorticoid antagonist (spironolactone) on the escalation of territorial aggression in a resident-intruder paradigm, and its modulation by social stimulus. We used naïve Wild Type Groningen - WTG - rats as residents, and naïve and previously defeated Wistar rats as intruders. The first encounter was 1h after the injection, and then repeated in 3 consecutive days. When WTG rats were confronted with naïve Wistar rats, single injections of spironolactone completely abolished the attack behaviour in the short term while enhancing it in the long term. When we used defeated Wistar rats, the spironolactone effect was not as great. The short-term reduction in aggressive behaviour was attributable to the blockade of mineralocorticoid receptors during the first encounters, while the enhancement in aggressive behaviour in the long term was suggested to be related to the imbalance between mineralocorticoid and glucocorticoid receptors during the stress response associated to the encounters.
authors.affiliation: Zoology Department, Cordoba University, 14071 Cordoba, Spain. zo1ruail@uco.es
authors.forename: Leire
authors.initials: L
authors.lastname: Ruiz-Aizpurua
authors.forename: Bauke
authors.initials: B
authors.lastname: Buwalda
authors.forename: Sietse F
authors.initials: SF
authors.lastname: De Boer
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000818:Animals; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology*; D051381:Rats; D013148:Spironolactone / Q000494:pharmacology*; D013731:Territoriality; D013997:Time Factors
chemical_list: D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone
keywords: Attack latency time; Escalation; MR/GR imbalance; Spironolactone; Territoriality