title: The circulating levels of TRAIL are extremely low after delivery but rapidly recover in both mothers and newborns.
abstract: TNF-related apoptosis inducing ligand (TRAIL) plasma levels was measured in plasma samples obtained 1h (time 1) and 2-3 days (time 2) after delivery in a group of healthy women (n=17) who underwent cesarean delivery, and showed a significantly increase from time 1 (39.3 pg/ml median; 41.2 ± 15.9 mean ± SD) to time 2 (71.6 pg/ml median; 73.8 ± 27.8 mean ± SD). Similarly, circulating TRAIL levels were extremely low in the plasma of newborns (n=41) within the first 24h after partum (time 1; 27.5 pg/ml, median; 31.5 ± 15.8 means ± SD), showing a significant increase 2-3 days after partum (time 2; 68.4 pg/ml, median; 75.1 ± 36.7 mean ± SD). It is also noteworthy that the highest levels of plasma TRAIL were observed in newborns with the following characteristics: (i) born at later gestational age, (ii) Apgar score >9, (iii) higher birth weight, (iv) born through vaginal partum. In conclusion, we have demonstrated for the first time that the levels of circulating TRAIL are markedly low in both mothers and children after delivery, rapidly rising thereafter. Moreover, the highest levels of TRAIL are observed in newborns with the best clinical parameters.
authors.affiliation: Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy. Electronic address: giorgio.zauli@unife.it.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Zauli
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Monasta
authors.forename: Liza
authors.initials: L
authors.lastname: Vecchi Brumatti
authors.forename: Chiara
authors.initials: C
authors.lastname: Agnoletto
authors.forename: Patrizia
authors.initials: P
authors.lastname: Volpi
authors.forename: Paola
authors.initials: P
authors.lastname: Secchiero
mesh_terms: D002585:Cesarean Section; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D036801:Parturition / Q000097:blood*; D011247:Pregnancy; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000097:blood*
chemical_list: D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human
keywords: Apgar; Delivery; Mothers, newborns; TRAIL