title: Image-guided therapies for myocardial repair: concepts and practical implementation.
abstract: Cell- and molecule-based therapeutic strategies to support wound healing and regeneration after myocardial infarction (MI) are under development. These emerging therapies aim at sustained preservation of ventricular function by enhancing tissue repair after myocardial ischaemia and reperfusion. Such therapies will benefit from guidance with regard to timing, regional targeting, suitable candidate selection, and effectiveness monitoring. Such guidance is effectively obtained by non-invasive tomographic imaging. Infarct size, tissue characteristics, muscle mass, and chamber geometry can be determined by magnetic resonance imaging and computed tomography. Radionuclide imaging can be used for the tracking of therapeutic agents and for the interrogation of molecular mechanisms such as inflammation, angiogenesis, and extracellular matrix activation. This review article portrays the hypothesis that an integrated approach with an early implementation of structural and molecular tomographic imaging in the development of novel therapies will provide a framework for achieving the goal of improved tissue repair after MI.
authors.affiliation: Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany. bengel.frank@mh-hannover.de
authors.forename: Frank M
authors.initials: FM
authors.lastname: Bengel
authors.forename: Richard T
authors.initials: RT
authors.lastname: George
authors.forename: Karl H
authors.initials: KH
authors.lastname: Schuleri
authors.forename: Albert C
authors.initials: AC
authors.lastname: Lardo
authors.forename: Kai C
authors.initials: KC
authors.lastname: Wollert
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D003287:Contrast Media; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D009203:Myocardial Infarction / Q000473:pathology* / Q000628:therapy*; D009206:Myocardium / Q000473:pathology; D015641:Radiography, Interventional / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D003287:Contrast Media
keywords: Acute myocardial infarction; Computed tomography; Magnetic resonance; Molecular imaging; Myocardial regeneration; Wound healing