title: An efficient synthesis of aldohexose-derived piperidine nitrones: precursors of piperidine iminosugars.
abstract: D-glucopyranose-derived and L-idopyranose-derived piperidine nitrones were synthesized in good overall yields through six-step reaction sequence starting from readily available 2,3,4,6-tetra-O-benzyl-D-glucopyranose. The method is efficient and could be general for the synthesis of aldohexose-derived piperidine nitrones which are precursors of piperidine iminosugars.
authors.affiliation: Beijing National Laboratory for Molecular Science, CAS Key Laboratory of Molecular Recoganition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Zhao
authors.forename: Jian-She
authors.initials: JS
authors.lastname: Zhu
authors.forename: Yue-Mei
authors.initials: YM
authors.lastname: Jia
authors.forename: Chu-Yi
authors.initials: CY
authors.lastname: Yu
mesh_terms: D050111:Imino Sugars / Q000138:chemical synthesis / Q000737:chemistry; D009589:Nitrogen Oxides / Q000138:chemical synthesis / Q000737:chemistry; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D050111:Imino Sugars; D009589:Nitrogen Oxides; D010880:Piperidines; C015388:nitrones