title: Relationship between major histocompatibility complex class I expression and prognosis in canine mammary gland tumors.
abstract: The aim of this study was to evaluate MHC class I expression and prognosis using tumor tissues surgically removed from 9 dogs with mammary gland carcinomas and from 13 dogs with complex carcinomas. We assessed MHC class I expression and its correlation with tumor size, B2M expression, infiltration of lymphocytes, histological grade and prognosis. Hematoxylin and eosin-stained sections were histologically graded using the Elston and Ellis grading method. MHC class I expression on tumor cells was evaluated using the avidin-biotin peroxidase complex method. Loss of MHC class I expression from canine mammary gland carcinomas was significantly correlated with poor prognosis (P<0.05). Loss of MHC class I expression showed no association with poor prognosis in canine mammary gland complex carcinomas, because the data were not balanced. Only 1 of 13 (7.6%) canine mammary gland complex carcinomas showed loss of MHC class I expression. All 13 of these dogs showed good prognosis. Thus, the low frequency of MHC class I expression loss from canine mammary gland complex carcinomas may be associated with good prognosis. Taken together, these results suggest that loss of MHC class I expression may be associated with poor prognosis in canine mammary gland carcinomas.
authors.affiliation: Laboratory of Veterinary Surgery, Department of Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-Oraikita, Izumisano, Osaka 598-8531, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Terumasa
authors.initials: T
authors.lastname: Shimada
authors.forename: Hideo
authors.initials: H
authors.lastname: Akiyoshi
authors.forename: Junichiro
authors.initials: J
authors.lastname: Shimizu
authors.forename: Cao
authors.initials: C
authors.lastname: Zheng
authors.forename: Li
authors.initials: L
authors.lastname: Yijyun
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Mie
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Hayashi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kuwamura
authors.forename: Fumio
authors.initials: F
authors.lastname: Hoshi
authors.forename: Fumihito
authors.initials: F
authors.lastname: Ohashi
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D007150:Immunohistochemistry / Q000662:veterinary; D015674:Mammary Neoplasms, Animal / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D016019:Survival Analysis; D001613:beta 2-Microglobulin / Q000235:genetics
chemical_list: D015395:Histocompatibility Antigens Class I; D001613:beta 2-Microglobulin