title: Generation of rhodium(I) carbenes from ynamides and their reactions with alkynes and alkenes.
abstract: Rh(I) carbenes were conveniently generated from readily available ynamides. These metal carbene intermediates could undergo metathesis with electron-rich or neutral alkynes to afford 2-oxopyrrolidines or be trapped by tethered alkenes to yield 3-azabicyclo[3.1.0]hexanes, a common skeleton in numerous bioactive pharmaceuticals. Although the scope of the former is limited, the latter reaction tolerates various substituted alkenes.
authors.affiliation: School of Pharmacy, University of Wisconsin, Madison , Wisconsin 53705, United States.
authors.forename: Renhe
authors.initials: R
authors.lastname: Liu
authors.forename: Gabrielle N
authors.initials: GN
authors.lastname: Winston-McPherson
authors.forename: Zhong-Yue
authors.initials: ZY
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.forename: Wangze
authors.initials: W
authors.lastname: Song
authors.forename: Ilia A
authors.initials: IA
authors.lastname: Guzei
authors.forename: Xiufang
authors.initials: X
authors.lastname: Xu
authors.forename: Weiping
authors.initials: W
authors.lastname: Tang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000480:Alkynes; D000577:Amides; D009942:Organometallic Compounds; C030011:carbene; D012238:Rhodium; D008697:Methane