title: Chemical constituents from Inula wissmanniana and their anti-inflammatory activities.
abstract: Two new inositol derivatives, 4-acetate-1,2,3,5-tetrakis(2-methyl-2-butenoate) inositol (1) and 3-acetate-1,2,4,5-tetrakis(2-methyl-2-butenoate) inositol (2), one new flavonolignan 23-o-acetylsilychristin A (3), and one new thymol derivative 3-hydroxy-4-(2-hydroxy-1-methylethyl)benzoic acid (4), along with 13 known compounds, including ten flavonolignans (5-14) and three thymol derivatives (15-17) were isolated from the aerial part of Inula wissmanniana. The structures of new compounds were elucidated by detailed spectroscopic analysis, including HRESIMS and 2D-NMR spectroscopic data. All the compounds were isolated from this plant for the first time. The anti-inflammatory activities of the compounds were tested against LPS-induced NO production in RAW 264.7 macrophages.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Wang
authors.forename: Xufeng
authors.initials: X
authors.lastname: Zhang
authors.forename: Panlei
authors.initials: P
authors.lastname: Wei
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Cheng
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.forename: Shikai
authors.initials: S
authors.lastname: Yan
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhang
authors.forename: Huizi
authors.initials: H
authors.lastname: Jin
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D038143:Inula; D008264:Macrophages / Q000187:drug effects / Q000473:pathology; D051379:Mice; D035261:Plant Components, Aerial
chemical_list: D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal