title: One-pot synthesis of linear-hyperbranched amphiphilic block copolymers based on polyglycerol derivatives and their micelles.
abstract: This paper describes the one-pot synthesis of a polyglycidol (PG)-based polymer, poly(ethoxyethyl glycidyl ether) (PEEGE)-b-[hyperbranched polyglycerol (hbPG)-co-PEEGE]x/y, its micelle formulation, and the ability to encapsulate a model therapeutic molecule. Amphiphilic block copolymers were prepared by the sequential addition of ethoxyethyl glycidyl ether (EEGE) to glycidol. The composition of the block copolymers varied from 62:38 to 92:8. Block copolymers with composition x:y≥66:34 were soluble only in organic solvents. Micelles were formulated by injection of deionized water into a tetrahydrofuran block copolymer solution with or without pyrene as a model hydrophobic molecule. The critical micelle concentration was 18.2-30.9 mg/L, and the micelle size was 100-250 nm. The pyrene-containing micelle rapidly collapsed on acidic exposure, allowing conversion of hydrophobic PEEGE to hydrophilic PG, thus, facilitating the release of the encapsulated pyrene. Cytotoxicity data showed high biocompatibility of PG-based block copolymers, suggesting their potential as a drug delivery carrier.
authors.affiliation: Department of Chemistry and Bioengineering, Faculty of Engineering, Iwate University, 4-3-5 Ueda, Morioka, Iwate 020-8551, Japan.
authors.forename: Yurie
authors.initials: Y
authors.lastname: Oikawa
authors.forename: Sueun
authors.initials: S
authors.lastname: Lee
authors.forename: Do Hyung
authors.initials: DH
authors.lastname: Kim
authors.forename: Dae Hwan
authors.initials: DH
authors.lastname: Kang
authors.forename: Byeong-Su
authors.initials: BS
authors.lastname: Kim
authors.forename: Kyohei
authors.initials: K
authors.lastname: Saito
authors.forename: Shigeko
authors.initials: S
authors.lastname: Sasaki
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Oishi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shibasaki
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D004852:Epoxy Compounds / Q000737:chemistry; D004987:Ethers / Q000737:chemistry*; D005663:Furans / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011409:Propylene Glycols / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D004852:Epoxy Compounds; D004987:Ethers; D005663:Furans; D008823:Micelles; D011108:Polymers; D011409:Propylene Glycols; C020344:glycidyl ethers; C512559:poly(ethoxyethyl glycidyl ether); C502907:polyglycidol; C018674:tetrahydrofuran