title: Long distance charge transport through DNA: quantification and extension of the hopping model.
abstract: Long distance charge transport through DNA occurs by a hopping mechanism. If the positive charge is injected into a guanine base, all guanines act as charge carriers. Because of the strong influence that the distance has on the charge-transfer step, DNA strands with long adenine:thymine sequences also involve adenine as charge carriers. A prerequsite for this mechanism is that the electron transfer to an adjacent adenine base is faster than the H2 O trapping reaction of the guanine radical cation. We have developed a model that can explain and qualitatively predict the product yields.
authors.affiliation: Department of Chemistry University of Basel St Johanns Ring 19, 4056 Basel, Switzerland. bernd.giese@unibas.ch
authors.forename: B
authors.initials: B
authors.lastname: Giese
authors.forename: M
authors.initials: M
authors.lastname: Spichty
mesh_terms: D000225:Adenine / Q000737:chemistry; D001483:Base Sequence; D002412:Cations / Q000737:chemistry; D004247:DNA / Q000032:analysis* / Q000737:chemistry; D004579:Electron Transport; D006147:Guanine / Q000737:chemistry; D007700:Kinetics; D008956:Models, Chemical; D010084:Oxidation-Reduction
chemical_list: D002412:Cations; D006147:Guanine; D004247:DNA; D000225:Adenine