title: Sleep deprivation impairs spatial retrieval but not spatial learning in the non-human primate grey mouse lemur.
abstract: A bulk of studies in rodents and humans suggest that sleep facilitates different phases of learning and memory process, while sleep deprivation (SD) impairs these processes. Here we tested the hypothesis that SD could alter spatial learning and memory processing in a non-human primate, the grey mouse lemur (Microcebus murinus), which is an interesting model of aging and Alzheimer's disease (AD). Two sets of experiments were performed. In a first set of experiments, we investigated the effects of SD on spatial learning and memory retrieval after one day of training in a circular platform task. Eleven male mouse lemurs aged between 2 to 3 years were tested in three different conditions: without SD as a baseline reference, 8 h of SD before the training and 8 h of SD before the testing. The SD was confirmed by electroencephalographic recordings. Results showed no effect of SD on learning when SD was applied before the training. When the SD was applied before the testing, it induced an increase of the amount of errors and of the latency prior to reach the target. In a second set of experiments, we tested the effect of 8 h of SD on spatial memory retrieval after 3 days of training. Twenty male mouse lemurs aged between 2 to 3 years were tested in this set of experiments. In this condition, the SD did not affect memory retrieval. This is the first study that documents the disruptive effects of the SD on spatial memory retrieval in this primate which may serve as a new validated challenge to investigate the effects of new compounds along physiological and pathological aging.
authors.affiliation: Mécanismes Adaptatifs et Evolution, UMR 7179 Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, Brunoy, France.
authors.forename: Anisur
authors.initials: A
authors.lastname: Rahman
authors.forename: Solène
authors.initials: S
authors.lastname: Languille
authors.forename: Yves
authors.initials: Y
authors.lastname: Lamberty
authors.forename: Claudio
authors.initials: C
authors.lastname: Babiloni
authors.forename: Martine
authors.initials: M
authors.lastname: Perret
authors.forename: Regis
authors.initials: R
authors.lastname: Bordet
authors.forename: Olivier J
authors.initials: OJ
authors.lastname: Blin
authors.forename: Tom
authors.initials: T
authors.lastname: Jacob
authors.forename: Alexandra
authors.initials: A
authors.lastname: Auffret
authors.forename: Esther
authors.initials: E
authors.lastname: Schenker
authors.forename: Jill
authors.initials: J
authors.lastname: Richardson
authors.forename: Fabien
authors.initials: F
authors.lastname: Pifferi
authors.forename: Fabienne
authors.initials: F
authors.lastname: Aujard
mesh_terms: D000818:Animals; D016565:Cheirogaleidae / Q000502:physiology*; D004569:Electroencephalography; D007858:Learning; D008297:Male; D012892:Sleep Deprivation / Q000503:physiopathology*