title: [Effects of tongfu decoction on rats' rapid gastric emptying].
abstract: OBJECTIVE
  To observe the effects of Tongfu Decoction (TFD) on the gastric emptying of normal rats, thus exploring whether it could promote gastric emptying rapidly.
  
  
  METHODS
  Thirty Sprague-Dawley (SD) rats were randomly divided into 3 groups, i.e., the normal control group, the domperidone group, and the TFD group, 10 in each group. They were respectively administered with normal saline, the domperidone suspension, and TFD by gastrogavage. Thirty min later the gastric emptying of mice was detected by single photon emission computed tomography technology (SPECT) labeled with 99m Tc-DTPA, and the gastric half-emptying time and the gastric emptying rate were calculated.
  
  
  RESULTS
  The gastric half-emptying time was (19.0 +/-1.7) min in the normal control group, (12.9 +/- 3.4) min in the domperidone group, and (12.7 +/- 4.1) min in the TFD group. Compared with the normal control group, the gastric half-emptying time was significantly shortened in the domperidone group and the TFD group (P <0.05). The gastric emptying rate at 15 min was 41.1% +/- 5. 8% in the normal control group, 52.9% +/- 10.9% in the domperidone group, and 56.0% +/- 10.3% in the TFD group, while at 30 min it was 65.6% +/- 2.8%, 72.9% +/- 2.6%, and 72.4% +/- 4.9%, respectively. Compared with the normal control group, the gastric emptying rate at 15 min and 30 min both significantly increased in the domperidone group and the TFD group (P <0.05). There was no statistical difference in the gastric half-emptying time or the gastric emptying rate between the two groups (P >0.05).
  
  
  CONCLUSIONS
  TFD showed similar effects as domperidone in rapidly promoting gastric emptying, and could shorten the gastric half-emptying time in normal rats.
authors.affiliation: Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Liang-mei
authors.initials: LM
authors.lastname: Zhang
authors.forename: Xin-yi
authors.initials: XY
authors.lastname: Zhu
authors.forename: Chang-song
authors.initials: CS
authors.lastname: Wang
authors.forename: Hai-chuan
authors.initials: HC
authors.lastname: Qu
authors.forename: Guo-xiang
authors.initials: GX
authors.lastname: Dou
mesh_terms: D000818:Animals; D004294:Domperidone / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005746:Gastric Emptying / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; D004294:Domperidone