title: MDR-ABC transporters: biomarkers in rheumatoid arthritis.
abstract: MDR-ABC transporters are widely expressed in cell types relevant to pathogenesis of rheumatoid arthritis. Many reports demonstrate the interaction of small molecule drugs with MDR-ABC transporters. Cell-based assays for disease relevant cell types can be easily gated and could reveal specific drug targets and may increase significance and utilisation of data in clinical practice. Many commonly used DMARDs (e.g. methotrexate, sulfasalazine, leflunomide/teriflunomide, hydroxychloroquine) are ABCG2 substrates. Consequently, the activity of this transporter in patients should be determined to understand the disposition and pharmacokinetics of the therapy. In addition, MDR-ABC transporters transport a variety of endobiotics that play important roles in cell proliferation, cell migration, angiogenesis and inflammation. Therefore, MDR-ABC transporters are important biomarkers in rheumatoid arthritis.
authors.affiliation: Solvo Biotechnology, Budaörs, Hungary. marki-zay@solvo.com.
authors.forename: János
authors.initials: J
authors.lastname: Márki-Zay
authors.forename: Katalin
authors.initials: K
authors.lastname: Tauberné Jakab
authors.forename: Péter
authors.initials: P
authors.lastname: Szerémy
authors.forename: Peter
authors.initials: P
authors.lastname: Krajcsi
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D018501:Antirheumatic Agents / Q000493:pharmacokinetics*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D004347:Drug Interactions; D018432:Drug Resistance, Multiple; D006801:Humans; D011379:Prognosis
chemical_list: D018528:ATP-Binding Cassette Transporters; D018501:Antirheumatic Agents; D015415:Biomarkers