title: [Pathogenetic correction of metabolic disturbances in chronic liver affections].
abstract: The available drugs for the treatment of chronic liver affections (the adequate model is chronic hepatitis C) include agents of metabolic therapy, whose efficacy is not always enough, that required the search for original mitochondrial substrates on the basis of succinate. Such agents were composed as a pharmaceutical group named "Substrates of Energetic Metabolism" or "Substrate Antihypoxants". The review presents the description of the pharmacological effects of remaxole and cytoflavin, evident from lower levels of active metabolites of oxygen that increases the clinical efficacy of the therapy. Their role in the metabolic reactions in chronic liver affections is exclusive and rather actual.
authors.forename: M G
authors.initials: MG
authors.lastname: Romantsov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Petrov
authors.forename: L N
authors.initials: LN
authors.lastname: Aleksandrova
authors.forename: D S
authors.initials: DS
authors.lastname: Sukhanov
authors.forename: A L
authors.initials: AL
authors.lastname: Kovalenko
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002908:Chronic Disease / Q000188:drug therapy; D004338:Drug Combinations; D005486:Flavin Mononucleotide / Q000494:pharmacology* / Q000627:therapeutic use; D019803:Glutathione Disulfide / Q000378:metabolism; D019698:Hepatitis C, Chronic / Q000188:drug therapy; D006801:Humans; D007290:Inosine Diphosphate / Q000494:pharmacology* / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D009536:Niacinamide / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000494:pharmacology; D013386:Succinates / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D020011:Protective Agents; C555877:Remaxol; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D019803:Glutathione Disulfide