title: Preventive effects of resveratrol against azoxymethane induced damage in rat liver.
abstract: BACKGROUND
  In recent years, due to modern lifestyles and exposure to chemical carcinogens, cancer cases are steadily increasing. From this standpoint, azoxymethane (AOM), a chemical carcinogen which causes de novo liver damage, and resveratrol, which is an antioxidant found in foods and protects against oxidative stress damage, are of interest. We here aimed to evaluate whether resveratrol could protect the liver tissues from the effects of AOM.
  
  
  METHODS
  The study was conducted in 4 groups, each consisting of seven rats, the first receiving only AOM (2 times per week, 5 mg/kg), group 2 AOM and resveratrol (2 times a week, 20 mg/kg), group 3 assessed only as a control and group 4 administered only resveratrol. At the end of the seventh week, the rats were sacrificed. Rat liver MDA, NO, GSH levels were analyzed biochemically, as well as the tissues being evaluated histopathologically.
  
  
  RESULTS
  MDA and NO increased in AOM group as signs of increased oxidative stress. The group concomitantly administered resveratrol was been found to be significantly decreased in MDA and NO levels and increased in GSH activity. However, there were no significant findings on histopathological evaluation.
  
  
  CONCLUSIONS
  In the light of these results, resveratrol appears to exert protective effect on oxidative stress in the liver tissue due to deleterious effects of chemical carcinogens.
authors.affiliation: Department of Radiation Oncology, Inonu University School of Medicine, Malatya, Turkey. simay.gurocak@inonu.edu.tr
authors.forename: Simay
authors.initials: S
authors.lastname: Gurocak
authors.forename: Ercan
authors.initials: E
authors.lastname: Karabulut
authors.forename: Nese
authors.initials: N
authors.lastname: Karadag
authors.forename: Dincer
authors.initials: D
authors.lastname: Ozgor
authors.forename: Neslihan
authors.initials: N
authors.lastname: Ozkeles
authors.forename: Aysun Bay
authors.initials: AB
authors.lastname: Karabulut
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001397:Azoxymethane / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D002273:Carcinogens; D013267:Stilbenes; D009569:Nitric Oxide; D008315:Malondialdehyde; D005978:Glutathione; D001397:Azoxymethane; D000077185:Resveratrol