title: [Studies of effective part group of piperine to regulating lipid].
abstract: The effects of effective part group on hyperlipidemia in animal were studied. The SD rats, hamsters and Kunming mouse were divided into blank group, model group. The positive control group and test group were fed with normal diet, blank and other groups were fed with high fat diet (mouse only a single intraperitoneal injection of egg yolk ). The corresponding concentration of solvent, simvastatin, effective part group of emulsion were given gavage once daily. The animal serum total cholesterol (TC) , triglyceride (TG) , low density lipoprotein (LDL) , high density lipoprotein (HDL) and liver TC, TG contents were determined to observe the effects of the effective fractions on blood lipid regulating function. Comparing with control group, the animial hyperlipidemia models of the SD rat (TC increase), mouse (TC, TG, LDL increase), hamsters ( TC, TG, LDL increase, HDL decrease) (P <0. 05, P < 0. 001) were successfully established. Piper longum effective part group could decrease the serum TC, TG, LDL (P <0.05, P < 0. 001) and liver TC, TG content, and elevate serum HDL levels (P <0.05, P <0.001). The golden hamster is ideal for hyperlipidemia model.
authors.affiliation: Department of Ent & HN Surgery, International Mongolian Hospital Hohhot, Hohhot 010065, China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Bao
authors.forename: Sheng-Sang
authors.initials: SS
authors.lastname: Na
authors.forename: Jing-Kun
authors.initials: JK
authors.lastname: Lu
mesh_terms: D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D052117:Benzodioxoles / Q000494:pharmacology* / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D006224:Cricetinae; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008075:Lipoproteins, HDL / Q000097:blood / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D031701:Piper / Q000737:chemistry; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use; D053284:Polyunsaturated Alkamides / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D000470:Alkaloids; D052117:Benzodioxoles; D004365:Drugs, Chinese Herbal; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D014280:Triglycerides; D002784:Cholesterol; C008922:piperine