title: Leucine supplementation increases serum insulin-like growth factor 1 concentration and liver protein/RNA ratio in rats after a period of nutritional recovery.
abstract: This study evaluated the effect of leucine on the protein status of rats submitted to 50% food restriction for 1 week, followed by 2 weeks of nutritional recovery. A significant increase of serum insulin-like growth factor 1 and protein/RNA ratio in the liver was observed in leucine-supplemented rats. There was no change in carcass, liver, or gastrocnemius protein content when compared with control animals. The supplementation tested did not favor protein status, although it improved some indicators of an anabolic state.
authors.affiliation: Department of Integrated Education in Health, CCS, Federal University of Espírito Santo, Vitória, Brazil. rogergp@usp.br
authors.forename: Rogerio G
authors.initials: RG
authors.lastname: Pedrosa
authors.forename: Jose
authors.initials: J
authors.lastname: Donato
authors.forename: Ivanir S
authors.initials: IS
authors.lastname: Pires
authors.forename: Julio
authors.initials: J
authors.lastname: Tirapegui
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D012313:RNA; D051381:Rats; D017208:Rats, Wistar
chemical_list: D012313:RNA; D007334:Insulin-Like Growth Factor I; D007930:Leucine