title: Short-term effects of a standardized glucose load on region-specific aortic pulse wave velocity assessed by MRI.
abstract: OBJECTIVE
  To assess the short-term effects of a standardized oral glucose load on regional aortic pulse wave velocity (PWV) using two-directional in-plane velocity encoded MRI.
  
  
  METHODS
  A randomized, controlled intervention was performed in 16 male subjects (mean ± standard deviation: age: 59±7 years, body mass index: 28±3 kg/m2) with impaired fasting glucose. The intervention consisted of an oral glucose load (75 grams of carbohydrates in 300 mL water) at 1 study day and water (300 mL) at the other study day. PWV was measured using multislice two-directional in-plane velocity-encoded MRI.
  
  
  RESULTS
  PWV in the proximal aorta at 1 h post-glucose load decreased compared with PWV 1-h post-water (delta PWV: -1.0±2.6 m/s versus 0.6±2.0 m/s, P=0.02). Eight responding subjects showed a significant decrease in PWV of the proximal aorta after the glucose load and had a decreased waist circumference (P=0.037) compared with nonresponders, being one of the major criteria of the metabolic syndrome. There was no significant change in PWV of the distal aorta at 1 h post-load comparing both intervention groups.
  
  
  CONCLUSIONS
  A standardized oral glucose load induces a decrease of the proximal, but not of the distal, aortic PWV. Regional response of aortic PWV may be associated with features of the metabolic syndrome.
authors.affiliation: Department of Endocrinology and General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Jacqueline T
authors.initials: JT
authors.lastname: Jonker
authors.forename: Nathanja
authors.initials: N
authors.lastname: Tjeerdema
authors.forename: Liselotte C R
authors.initials: LC
authors.lastname: Hensen
authors.forename: Hildo J
authors.initials: HJ
authors.lastname: Lamb
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Romijn
authors.forename: Johannes W A
authors.initials: JW
authors.lastname: Smit
authors.forename: Jos J M
authors.initials: JJ
authors.lastname: Westenberg
authors.forename: Albert
authors.initials: A
authors.lastname: de Roos
mesh_terms: D000284:Administration, Oral; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis / Q000379:methods*; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D005947:Glucose
keywords: aorta; arterial stiffness; magnetic resonance imaging; pulse wave velocity; standardized glucose load