title: Laboratory features throughout the disease course of influenza A (H1N1) virus infection.
abstract: BACKGROUND
  Influenza has emerged every year but a complete profile of laboratory indices throughout the disease course remains unknown.
  
  
  METHODS
  Clinical data was collected from 28 confirmed cases of the pandemic influenza H1N1 2009. The levels of serum iron (Fe), carbon dioxide combining power (CO2-CP), total complement hemolytic activity (CH50), C-reactive protein (CRP), and white blood cell (WBC) and differential count were analyzed.
  
  
  RESULTS
  Major laboratory abnormalities recokled for patients upon admission were lymphopenia (96.4%), eosinopenia (50.0%), hypoferremia (92.9%), decreased levels of serum CO2-CP (60.7%), increased levels of serum CRP (84.6%) and serum CH50 (71.4%). The serum iron and CO2-CP concentration and the counts for lymphocytes, eosinophils, and basophils were significantly increased four days after sickness was noticed compared with the first three days of illness (p < 0.05). The total WBC and neutrophil counts were significantly decreased four days after onset of illness compared with the counts over the first three days (p < 0.05). The monocyte count and CRP concentration was significantly decreased 7 days after onset of illness compared with first 3 days after illness onset (p < 0.05). The serum CH50 concentrations were higher than the normal range during disease course and significantly elevated 7 days after onset of illness compared with the first 6 days after illness onset (p < 0.05).
  
  
  CONCLUSIONS
  The serum levels of iron, CO2-CP, CH50, CRP, and WBC and differential count Were significantly varied during the whole pandemic influenza (H1N1) 2009. The development of WBC count in patients with influenza may be an effective predictor for severity of illness.
authors.affiliation: Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, People's Republic of China.
authors.forename: Honghui
authors.initials: H
authors.lastname: Shen
authors.forename: Boan
authors.initials: B
authors.lastname: Li
authors.forename: Bingke
authors.initials: B
authors.lastname: Bai
authors.forename: Jun
authors.initials: J
authors.lastname: Hou
authors.forename: Zhe
authors.initials: Z
authors.lastname: Xu
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Panyong
authors.initials: P
authors.lastname: Mao
authors.forename: Aixia
authors.initials: A
authors.lastname: Liu
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Tongsheng
authors.initials: T
authors.lastname: Guo
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Chen
authors.forename: Weimin
authors.initials: W
authors.lastname: Nie
authors.forename: Enqiang
authors.initials: E
authors.lastname: Qin
authors.forename: Yuanli
authors.initials: Y
authors.lastname: Mao
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis; D019411:Clinical Laboratory Techniques; D015941:Complement Hemolytic Activity Assay; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000097:blood* / Q000821:virology; D007501:Iron / Q000097:blood; D007958:Leukocyte Count
chemical_list: D002097:C-Reactive Protein; D007501:Iron