title: Human papillomavirus-32-associated focal epithelial hyperplasia accompanying HPV-16-positive papilloma-like lesions in oral mucosa.
abstract: Human papillomavirus infection can cause a variety of benign or malignant oral lesions, and the various genotypes can cause distinct types of lesions. To our best knowledge, there has been no report of 2 different human papillomavirus-related oral lesions in different oral sites in the same patient before. This paper reported a patient with 2 different oral lesions which were clinically and histologically in accord with focal epithelial hyperplasia and oral papilloma, respectively. Using DNA extracted from these 2 different lesions, tissue blocks were tested for presence of human papillomavirus followed by specific polymerase chain reaction testing for 6, 11, 13, 16, 18, and 32 subtypes in order to confirm the clinical diagnosis. Finally, human papillomavirus-32-positive focal epithelial hyperplasia accompanying human papillomavirus-16-positive oral papilloma-like lesions were detected in different sites of the oral mucosa. Nucleotide sequence sequencing further confirmed the results. So in our clinical work, if the simultaneous occurrences of different human papillomavirus associated lesions are suspected, the multiple biopsies from different lesions and detection of human papillomavirus genotype are needed to confirm the diagnosis.
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Sichuan, China.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.forename: Jiayi
authors.initials: J
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Lei
authors.forename: Yanzhong
authors.initials: Y
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.forename: Hongxia
authors.initials: H
authors.lastname: Dan
authors.forename: Xin
authors.initials: X
authors.lastname: Zeng
authors.forename: Qianming
authors.initials: Q
authors.lastname: Chen
mesh_terms: D052685:Alphapapillomavirus / Q000145:classification / Q000302:isolation & purification*; D001706:Biopsy; D002648:Child; D017573:Focal Epithelial Hyperplasia / Q000821:virology*; D005838:Genotype; D005887:Gingival Neoplasms / Q000821:virology; D052140:Human papillomavirus 11 / Q000302:isolation & purification; D052162:Human papillomavirus 16 / Q000302:isolation & purification / Q000502:physiology*; D052161:Human papillomavirus 18 / Q000302:isolation & purification; D052163:Human papillomavirus 6 / Q000302:isolation & purification; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000821:virology*; D010212:Papilloma / Q000821:virology*; D030361:Papillomavirus Infections / Q000821:virology*; D016133:Polymerase Chain Reaction; D014062:Tongue Neoplasms / Q000821:virology