title: Current understanding of the role of the Brd4 protein in the papillomavirus lifecycle.
abstract: The Brd4 protein is an epigenetic reader that is central to regulation of cellular transcription and mitotic bookmarking. The transcription and replication proteins of many viruses interact with Brd4. We describe the multiple roles of Brd4 in the papillomavirus lifecycle.
authors.affiliation: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. amcbride@nih.gov
authors.forename: Alison A
authors.initials: AA
authors.lastname: McBride
authors.forename: Moon Kyoo
authors.initials: MK
authors.lastname: Jang
mesh_terms: D018797:Cell Cycle Proteins; D054884:Host-Pathogen Interactions; D006801:Humans; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism*; D027383:Papillomaviridae / Q000502:physiology*; D014176:Protein Biosynthesis; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000378:metabolism*; D014779:Virus Replication; D000092468:Bromodomain Containing Proteins
chemical_list: D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; D014764:Viral Proteins; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins