title: Bisabolangelone inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.
abstract: Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. In this study, we investigated the anti-inflammatory mechanisms of BISA in dendritic cells (DCs), which play an essential role in innate and adaptive immune responses. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. Taken together, our data suggest that BISA inhibited DC functions by blocking MAPK and NF-κB signaling.
authors.affiliation: College of Pharmacy & CBITRC, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
authors.forename: Hyung Sook
authors.initials: HS
authors.lastname: Kim
authors.forename: Young June
authors.initials: YJ
authors.lastname: Lee
authors.forename: Hong Kyung
authors.initials: HK
authors.lastname: Lee
authors.forename: Ji Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Yunsoo
authors.initials: Y
authors.lastname: Park
authors.forename: Jong Soon
authors.initials: JS
authors.lastname: Kang
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
authors.forename: Youngsoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Sang-Bae
authors.initials: SB
authors.lastname: Han
mesh_terms: D029969:Angelica / Q000737:chemistry; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D048749:Cytokinesis / Q000187:drug effects; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D004705:Endocytosis / Q000187:drug effects; D020834:Ethnopharmacology; D005260:Female; D008213:Lymphocyte Activation / Q000187:drug effects; D020935:MAP Kinase Signaling System / Q000187:drug effects*; D055670:Medicine, Korean Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D056910:Republic of Korea; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D016328:NF-kappa B; D047428:Protein Kinase Inhibitors; D012717:Sesquiterpenes; C455067:bisabolangelone
keywords: BISA; Bisabolangelone; C-Jun N-terminal kinase; DCs; Dendritic cells; ERK; IκB; JNK; MAPK; MAPKs; NF-κB; bisabolangelone; dendritic cells; extracellular signal-regulated kinase; inhibits NF-κB; mitogen-activated protein kinase