title: Acellular flexor tendon allografts: a new horizon for tendon reconstruction.
abstract: Flexor tendon injuries continue to pose a significant challenge to the hand surgeon. In particular, chronic tendon ruptures with adhesions of the tendons and sheath, damage or loss of the intrasynovial flexor tendons in zone II, and combined soft tissue and bone injuries present especially difficult problems for restoring satisfactory digital function. This challenge in flexor tendon reconstruction has motivated hand surgeons to explore and develop novel solutions for nearly a century. Recent advances and techniques in processing and decellularizing allograft human flexor tendon constructs may prove to be a new horizon for tendon reconstruction.
authors.affiliation: University of Virginia Department of Plastic Surgery, and the University of Virginia School of Medicine, Charlottesville, Virginia. Electronic address: dbd9u@virginia.edu.
authors.forename: David B
authors.initials: DB
authors.lastname: Drake
authors.forename: Alexandra C
authors.initials: AC
authors.lastname: Tilt
authors.forename: Brent R
authors.initials: BR
authors.lastname: DeGeorge
mesh_terms: D064591:Allografts; D005260:Female; D005544:Forecasting; D006230:Hand Injuries / Q000601:surgery; D006801:Humans; D008297:Male; D019651:Plastic Surgery Procedures / Q000379:methods* / Q000639:trends; D018570:Risk Assessment; D013708:Tendon Injuries / Q000175:diagnosis / Q000601:surgery*; D013710:Tendons / Q000601:surgery / Q000637:transplantation*; D023822:Tissue Engineering; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
keywords: Reconstruction; allograft; intrasynovial; reconstruction; tendon