title: Proteolytic remodeling of the ECM and the geometric control of stem cell fate.
abstract: The mechanism by which mechanosignal transduction regulates stem cell fate is not well understood. In this issue of Developmental Cell, Tang et al. (2013) demonstrate that catalytic function of the metalloproteinase MT1-MMP controls ECM structure, cell shape, and an integrin/Rho/YAP-TAZ signaling axis to control osteogenic stem cell fate.
authors.affiliation: Department of Cell and Regenerative Biology and Laboratory for Cell and Molecular Biology, University of Wisconsin, Madison, WI 53706, USA. pjkeely@wisc.edu
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Keely
mesh_terms: D000217:Acyltransferases; D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D018797:Cell Cycle Proteins; D006801:Humans; D019012:Integrin beta1 / Q000378:metabolism*; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; D019012:Integrin beta1; C507096:Mmp14 protein, mouse; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C486223:Yap1 protein, mouse; D000217:Acyltransferases; C486363:tafazzin protein, mouse; D053511:Matrix Metalloproteinase 14