title: Therapeutic approaches in the stimulation of the coronary collateral circulation.
abstract: Arteriogenesis as a way to restore blood flow after arterial occlusion has been under investigation for the treatment of coronary artery disease (CAD) for decades. Therapeutic approaches so far have included delivery of cytokines and growth factors as well as mechanical stimulation such as external counterpulsation. As knowledge on the mechanisms of arteriogenesis expanded, new therapeutic approaches have emerged. This review summarizes recent attempts to stimulate the growth of the coronary vasculature and discusses their potential in clinical application. This article also delivers an overview of current studies and trials on coronary arteriogenesis.
authors.forename: Achim
authors.initials: A
authors.lastname: Degen
authors.forename: Dominic
authors.initials: D
authors.lastname: Millenaar
authors.affiliation: Klinik fur Innere Medizin III, (Kardiologie, Angiologie und Internistische Intensivmedizin), Kirrberger Strasse, Geb. 40, Universitatsklinikum des Saarlandes, 66421 Homburg/ Saar, Germany. Stephan.Schirmer@uniklinikum-saarland.de.
authors.forename: Stephan H
authors.initials: SH
authors.lastname: Schirmer
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use; D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D003097:Collateral Circulation / Q000502:physiology*; D003324:Coronary Artery Disease / Q000503:physiopathology / Q000628:therapy*; D003326:Coronary Circulation / Q000502:physiology*; D015908:Counterpulsation / Q000379:methods; D016207:Cytokines / Q000627:therapeutic use; D004195:Disease Models, Animal; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology
chemical_list: D043925:Angiogenesis Inducing Agents; D016207:Cytokines