title: In vivo comparative property study of the bioactivity of coated Mg-3Zn-0.8Zr alloy.
abstract: In this in vivo study, degradable Mg-3Zn-0.8Zr cylinders were coated with a calcium phosphorus compound (Ca-P) layer or a magnesium fluoride (MgF2) layer; uncoated Mg-3Zn-0.8Zr alloy was used as a control. These were then implanted intramedullary into the femora of nine Japanese big-ear white rabbits for implantation periods of 1, 2 and 3 months. During the postoperative observation period with radiographic examination, the results showed that the MgF2-coated implants were tolerated well compared to the Ca-P-coated implants and uncoated implants. Moreover, large amounts of cells, rich fibrillar collagen and calcium and phosphorus products were found on the surface of the MgF2-coated implants using scanning electron microscopy. Micro-computed tomography further showed a slight decrease in volume (23.85%) and a greater increase in new bone mass (new bone volume fraction=11.56%, tissue mineral density=248.81 mg/cm(3)) for the MgF2-coated implants in comparison to uncoated and Ca-P compound-coated implants after 3 months of implantation.
authors.affiliation: School of Materials Science and Engineering, Tianjin University of Technology, 300384 Tianjin, China.
authors.forename: Jin'e
authors.initials: J
authors.lastname: Sun
authors.forename: Jingbo
authors.initials: J
authors.lastname: Wang
authors.forename: Hongfeng
authors.initials: H
authors.lastname: Jiang
authors.forename: Minfang
authors.initials: M
authors.lastname: Chen
authors.forename: Yanze
authors.initials: Y
authors.lastname: Bi
authors.forename: Debao
authors.initials: D
authors.lastname: Liu
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000737:chemistry* / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D005269:Femur / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D005459:Fluorides / Q000737:chemistry*; D017616:Magnesium Compounds / Q000737:chemistry*; D017553:Phosphorus Compounds / Q000737:chemistry; D019736:Prostheses and Implants; D011817:Rabbits; D014057:Tomography, X-Ray Computed; D015032:Zinc / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000497:Alloys; D018786:Bone Substitutes; D017616:Magnesium Compounds; D017553:Phosphorus Compounds; C031288:magnesium fluoride; D003094:Collagen; D015040:Zirconium; D015032:Zinc; D005459:Fluorides; D002118:Calcium