title: Pathophysiology of white-nose syndrome in bats: a mechanistic model linking wing damage to mortality.
abstract: White-nose syndrome is devastating North American bat populations but we lack basic information on disease mechanisms. Altered blood physiology owing to epidermal invasion by the fungal pathogen Geomyces destructans (Gd) has been hypothesized as a cause of disrupted torpor patterns of affected hibernating bats, leading to mortality. Here, we present data on blood electrolyte concentration, haematology and acid-base balance of hibernating little brown bats, Myotis lucifugus, following experimental inoculation with Gd. Compared with controls, infected bats showed electrolyte depletion (i.e. lower plasma sodium), changes in haematology (i.e. increased haematocrit and decreased glucose) and disrupted acid-base balance (i.e. lower CO2 partial pressure and bicarbonate). These findings indicate hypotonic dehydration, hypovolaemia and metabolic acidosis. We propose a mechanistic model linking tissue damage to altered homeostasis and morbidity/mortality.
authors.affiliation: Department of Biology, University of Winnipeg, Winnipeg, Manitoba, Canada.
authors.forename: Lisa
authors.initials: L
authors.lastname: Warnecke
authors.forename: James M
authors.initials: JM
authors.lastname: Turner
authors.forename: Trent K
authors.initials: TK
authors.lastname: Bollinger
authors.forename: Vikram
authors.initials: V
authors.lastname: Misra
authors.forename: Paul M
authors.initials: PM
authors.lastname: Cryan
authors.forename: David S
authors.initials: DS
authors.lastname: Blehert
authors.forename: Gudrun
authors.initials: G
authors.lastname: Wibbelt
authors.forename: Craig K R
authors.initials: CK
authors.lastname: Willis
mesh_terms: D000136:Acid-Base Equilibrium; D000818:Animals; D001203:Ascomycota / Q000472:pathogenicity* / Q000502:physiology; D001786:Blood Glucose / Q000032:analysis; D002685:Chiroptera / Q000097:blood; D003681:Dehydration / Q000382:microbiology / Q000503:physiopathology; D006400:Hematocrit; D020896:Hypovolemia / Q000382:microbiology / Q000503:physiopathology; D008350:Manitoba; D009181:Mycoses / Q000382:microbiology / Q000503:physiopathology*; D013217:Starvation / Q000382:microbiology / Q000503:physiopathology; D014883:Water-Electrolyte Imbalance / Q000382:microbiology / Q000503:physiopathology*; D014921:Wings, Animal / Q000382:microbiology / Q000473:pathology*
chemical_list: D001786:Blood Glucose
keywords: Geomyces destructans; dehydration; hibernation; hypovolemia; plasma electrolytes