title: Posterior fossa tumors and their impact on sleep and ventilatory control: a clinical perspective.
abstract: The cerebellum, classically viewed as a motor structure of the brain, may play a role in respiration. Brainstem dysfunction has been implicated in sleep disordered breathing (SDB), but apnea after surgery of brain tumors in the posterior fossa, not involving the brainstem has been reported. We report four cases with posterior fossa tumors without brainstem invasion who suffered SDB after surgery diagnosed by polysomnography (PSG). Advanced MRI techniques with DTI were used to find correlations with SDB. Abnormal signals in the superior, middle and inferior cerebellar peduncles were seen in these patients with the most severe changes in the inferior peduncle. SDB may be under diagnosed in the setting of posterior fossa tumors without brainstem involvement. Damage to the cerebellar peduncles, especially the inferior cerebellar peduncle, without brainstem involvement, can cause significant disruption of respiration.
authors.affiliation: Department of Neurological Surgery, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, Washington, United States. Electronic address: amy.lee@seattlechildrens.org.
authors.forename: Amy
authors.initials: A
authors.lastname: Lee
authors.forename: Maida Lynn
authors.initials: ML
authors.lastname: Chen
authors.forename: Sergey
authors.initials: S
authors.lastname: Abeshaus
authors.forename: Andrew
authors.initials: A
authors.lastname: Poliakov
authors.forename: Jeffrey G
authors.initials: JG
authors.lastname: Ojemann
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D015192:Infratentorial Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D017286:Polysomnography / Q000379:methods; D012123:Pulmonary Ventilation / Q000502:physiology*; D012189:Retrospective Studies; D012890:Sleep / Q000502:physiology*; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology
keywords: Brain neoplasm; Cerebellum; Respiration; Sleep disordered breathing