title: Three new ursane-type triterpenes from the leaves of Rehmannia glutinosa.
abstract: Three new ursane-type triterpenes, glutinosalactone A-C (1-3), were isolated from the 50% aqueous acetone extract of the leaves of Rehmannia glutinosa. Their structures were elucidated on the basis of spectral analysis (IR, NMR and MS spectroscopy). The cytotoxic effects of compounds 1-3 against three human cancer cell lines (MCF-7, MG63 and HepG2) were also evaluated. Compound 3 showed cytotoxic activities with IC50 values of 8.35-39.25 μM.
authors.affiliation: School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Zhang
authors.forename: Wei-Sheng
authors.initials: WS
authors.lastname: Feng
authors.forename: Xiao-Ke
authors.initials: XK
authors.lastname: Zheng
authors.forename: Yan-Gang
authors.initials: YG
authors.lastname: Cao
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Lv
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Hai-Xue
authors.initials: HX
authors.lastname: Kuang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry*; D032267:Rehmannia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes; C586572:glutinosalactone A; C586574:glutinosalactone B; C586573:glutinosalactone C
keywords: Cytotoxic activity; Rehmannia glutinosa; Scrophulariaceae; Ursane-type triterpenes