title: One-pot gold-catalyzed aminofluorination of unprotected 2-alkynylanilines.
abstract: A tandem gold(I)-catalyzed aminocylization/fluorination and a two-step, one-pot gold(III)-catalyzed cyclization/electrophilic fluorination provide a convenient and general method for the synthesis of 3,3-difluoro-2-substituted-3H-indoles in good yield under mild conditions. Extension of the procedure to the synthesis of 2-aryl-3-fluoro-1H-indoles is described. The reaction proceeds smoothly in green ethanol and does not require any base, acid, or N-protective group.
authors.affiliation: Dipartimento di Scienze Fisiche e Chimiche, Università di L'Aquila, Via Vetoio-67010 Capitol(AQ), Italy. arcadi@univaq.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Arcadi
authors.forename: Emanuela
authors.initials: E
authors.lastname: Pietropaolo
authors.forename: Antonello
authors.initials: A
authors.lastname: Alvino
authors.forename: Véronique
authors.initials: V
authors.lastname: Michelet