title: Phenotype-Genotype Integrator (PheGenI): synthesizing genome-wide association study (GWAS) data with existing genomic resources.
abstract: Rapidly accumulating data from genome-wide association studies (GWASs) and other large-scale studies are most useful when synthesized with existing databases. To address this opportunity, we developed the Phenotype-Genotype Integrator (PheGenI), a user-friendly web interface that integrates various National Center for Biotechnology Information (NCBI) genomic databases with association data from the National Human Genome Research Institute GWAS Catalog and supports downloads of search results. Here, we describe the rationale for and development of this resource. Integrating over 66,000 association records with extensive single nucleotide polymorphism (SNP), gene, and expression quantitative trait loci data already available from the NCBI, PheGenI enables deeper investigation and interrogation of SNPs associated with a wide range of traits, facilitating the examination of the relationships between genetic variation and human diseases.
authors.affiliation: Division of Genomic Medicine, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
authors.forename: Erin M
authors.initials: EM
authors.lastname: Ramos
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Hoffman
authors.affiliation: Division of Genomic Medicine, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
authors.forename: Heather A
authors.initials: HA
authors.lastname: Junkins
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA.
authors.forename: Donna
authors.initials: D
authors.lastname: Maglott
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA.
authors.forename: Lon
authors.initials: L
authors.lastname: Phan
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Sherry
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA.
authors.forename: Mike
authors.initials: M
authors.lastname: Feolo
authors.affiliation: Division of Genomic Medicine, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
authors.forename: Lucia A
authors.initials: LA
authors.lastname: Hindorff
mesh_terms: D019295:Computational Biology; D030541:Databases, Genetic; D015894:Genome, Human; D055106:Genome-Wide Association Study; D023281:Genomics; D005838:Genotype; D006801:Humans; D020407:Internet; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012984:Software