title: Variations of lipoprotein(a) levels in the metabolic syndrome: a report from the Maracaibo City Metabolic Syndrome Prevalence Study.
abstract: BACKGROUND
  Lipoprotein(a) [Lp(a)] is a known risk factor for cardiovascular disease, yet its influence on metabolic syndrome (MS) is still controversial. The purpose of this study was to assess the impact generated by this diagnosis in serum Lp(a) concentrations.
  
  
  METHODS
  A total of 1807 subjects of both genders (55.3% women and 44.7% men) belonging to the Maracaibo City Metabolic Syndrome Prevalence Study were evaluated. Results were expressed as Mean ± SD, determining differences through Student's t-test and One-Way ANOVA test. Multiple logistic regression models were utilized for analyzing factors associated with elevated serum Lp(a) levels and MS. Total cholesterol and LDL-C were corrected according to Lp(a)-Cholesterol when necessary.
  
  
  RESULTS
  No differences were found in Lp(a) values between genders; P = 0,292. The association between MS and the classification of Lp(a) was statistically significant (χ (2) = 28.33; P < 0,0001), with greater levels in subjects with this diagnosis. In the univariate analysis, subjects with each of the separate diagnostic criteria showed higher serum Lp(a) concentrations, except for hyperglycemia.
  
  
  CONCLUSIONS
  Lp(a) values exhibit important variations regarding MS and each of its components. Impaired fasting glucose appeared as a protecting factor against elevated Lp(a) concentrations, whereas its association with LDL-C and hs-CRP suggests a potential pro-inflammatory role.
authors.affiliation: Endocrine-Metabolic Research Center, "Dr. Félix Gómez," Faculty of Medicine, University of Zulia, Maracaibo 4004, Venezuela. vbermudez@hotmail.com
authors.forename: Valmore
authors.initials: V
authors.lastname: Bermúdez
authors.forename: Joselyn
authors.initials: J
authors.lastname: Rojas
authors.forename: Juan
authors.initials: J
authors.lastname: Salazar
authors.forename: Luis
authors.initials: L
authors.lastname: Bello
authors.forename: Roberto
authors.initials: R
authors.lastname: Añez
authors.forename: Alexandra
authors.initials: A
authors.lastname: Toledo
authors.forename: Maricarmen
authors.initials: M
authors.lastname: Chacín
authors.forename: Miguel
authors.initials: M
authors.lastname: Aguirre
authors.forename: Marjorie
authors.initials: M
authors.lastname: Villalobos
authors.forename: Mervin
authors.initials: M
authors.lastname: Chávez
authors.forename: María Sofía
authors.initials: MS
authors.lastname: Martínez
authors.forename: Wheeler
authors.initials: W
authors.lastname: Torres
authors.forename: Yaquelin
authors.initials: Y
authors.lastname: Torres
authors.forename: José
authors.initials: J
authors.lastname: Mejías
authors.forename: Edgardo
authors.initials: E
authors.lastname: Mengual
authors.forename: Liliana
authors.initials: L
authors.lastname: Rojas
authors.forename: Milagro
authors.initials: M
authors.lastname: Sánchez de Rosales
authors.forename: Ana
authors.initials: A
authors.lastname: Quevedo
authors.forename: Raquel
authors.initials: R
authors.lastname: Cano
authors.forename: Mayela
authors.initials: M
authors.lastname: Cabrera
authors.forename: Rafael
authors.initials: R
authors.lastname: París
authors.forename: Adonías
authors.initials: A
authors.lastname: Lubo
authors.forename: María
authors.initials: M
authors.lastname: Montiel
authors.forename: Climaco
authors.initials: C
authors.lastname: Cano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014687:Venezuela / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D017270:Lipoprotein(a); D014280:Triglycerides; D002784:Cholesterol