title: Early community context, genes, and youth body mass index trajectories: an investigation of gene-community interplay over early life course.
abstract: OBJECTIVE
  To investigate additive and interactive influences of community adversity and cumulative genetic sensitivity on youth body mass index (BMI) trajectories over adolescence and young adulthood.
  
  
  METHODS
  We used latent growth curve modeling to examine BMI trajectories over three waves (1995, 2001, and 2008) of the National Longitudinal Study of Adolescent Health (n = 14,563). We measured genetic sensitivity by a cumulative index of genes associated with serotonin and dopamine functions.
  
  
  RESULTS
  Community adversity was positively associated with the initial level and rate of change in BMI trajectories over time. Adolescents experiencing community adversity had a higher BMI at Wave 1 and gained weight more quickly than those who did not live in adverse communities. Community adversity interacted with cumulative genetic sensitivity to explain variation in the rate of change in BMI trajectories. The influence of community adversity was greater for those with more sensitivity alleles than those with fewer sensitivity alleles. Gender, race/ethnicity, and family contexts were also associated with youth BMI trajectories.
  
  
  CONCLUSIONS
  Community adversity in early adolescence, and its interaction with genes, has far-reaching consequences, including the rate of change in BMI trajectories extending into adulthood. This work has practical implications for future intervention/prevention programs.
authors.affiliation: Human Development and Family Science, University of Georgia, Athens, GA 30602, USA.
authors.forename: Kandauda K A S
authors.initials: KK
authors.lastname: Wickrama
authors.forename: Catherine Walker
authors.initials: CW
authors.lastname: O'Neal
authors.forename: Tae Kyoung
authors.initials: TK
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000483:Alleles; D015992:Body Mass Index; D002648:Child; D005006:Ethnicity; D005191:Family Characteristics; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012307:Risk Factors; D062487:Social Marginalization
keywords: Community context; Obesity; Tracking of body mass index