title: [Paclitaxel induced apoptotic genes and pathways alterations: a review].
abstract: Taxol has clinical efficacy on many malignant tumors, thus having a good market prospects. The anti-cancer mechanism of taxol is to arrest the cell cycle of tumor cells, leading to apoptosis. Based on our research over the years, we reviewed the latest developments in signaling pathways, the effects of related genes and proteins on apoptosis during paclitaxel-induced apoptosis process, including the paclitaxel-producing gene in microbial fermentation process, cyclin, telomerase of apoptosis.
authors.affiliation: Laboratory of Microbiology, College of Life Science, Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin 150080, Heilongjiang, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Kang
authors.forename: Chuanzhen
authors.initials: C
authors.lastname: Sun
authors.forename: Ye
authors.initials: Y
authors.lastname: Xiao
authors.forename: Kai
authors.initials: K
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D006801:Humans; D020935:MAP Kinase Signaling System / Q000187:drug effects; D016328:NF-kappa B / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D017239:Paclitaxel / Q000494:pharmacology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D015398:Signal Transduction; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D016328:NF-kappa B; D019869:Phosphatidylinositol 3-Kinases; D048051:p38 Mitogen-Activated Protein Kinases; D017239:Paclitaxel