title: Platelets as cellular effectors of inflammation in vascular diseases.
abstract: Platelets are chief effector cells in hemostasis. In addition, they are multifaceted inflammatory cells with functions that span the continuum from innate immune responses to adaptive immunity. Activated platelets have key thromboinflammatory activities in a variety of vascular disorders and vasculopathies. Recently identified inflammatory and immune activities provide insights into the biology of these versatile blood cells that are directly relevant to human vascular diseases.
authors.affiliation: Department of Medicine and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Rondina
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Weyrich
authors.forename: Guy A
authors.initials: GA
authors.lastname: Zimmerman
mesh_terms: D001792:Blood Platelets / Q000276:immunology*; D006801:Humans; D015539:Platelet Activation / Q000276:immunology*; D013927:Thrombosis / Q000276:immunology*; D014652:Vascular Diseases / Q000276:immunology*; D014657:Vasculitis / Q000276:immunology*
keywords: immune responses; inflammation; platelets; vasculopathy; vessel diseases