title: The CXXC-TET bridge--mind the methylation gap!
abstract: CG-rich DNA "reader" proteins that bind non-methylated CpG sequences have emerged as critical factors to the process of cell differentiation and development. In a recent paper in Nature, Ko et al. show that the CXXC domain protein, IDAX, plays a crucial role as a CG-rich DNA-binding factor in the regulation of Ten-Eleven-Translocation 2 (TET2) protein function.
authors.affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
authors.forename: Donncha S
authors.initials: DS
authors.lastname: Dunican
authors.forename: Sari
authors.initials: S
authors.lastname: Pennings
authors.forename: Richard R
authors.initials: RR
authors.lastname: Meehan
mesh_terms: D044503:5-Methylcytosine / Q000378:metabolism*; D000818:Animals; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D044503:5-Methylcytosine