title: Risk factors for periprosthetic joint infection following primary total hip arthroplasty: a case control study.
abstract: The purpose of this study was to identify the specific comorbidities and demographic factors that are independently associated with an increased risk of periprosthetic joint infection (PJI) in total hip arthroplasty (THA) patients. A case-control study design was used to compare 88 patients who underwent unilateral primary THA and developed PJI with 499 unilateral primary THA patients who did not develop PJI. The impact of 18 comorbid conditions and other demographic factors on PJI was examined. Depression, obesity, cardiac arrhythmia, and male gender were found to be independently associated with an increased risk of PJI in THA patients. This information is important to consider when counseling patients on the risks associated with elective THA, and for risk-adjusting publicly reported THA outcomes.
authors.affiliation: Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California; University of California, San Francisco, San Francisco, Philip R. Lee Institute for Health Policy Studies, San Francisco, California.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Bozic
authors.forename: Derek T
authors.initials: DT
authors.lastname: Ward
authors.forename: Edmund C
authors.initials: EC
authors.lastname: Lau
authors.forename: Vanessa
authors.initials: V
authors.lastname: Chan
authors.forename: Nathan G
authors.initials: NG
authors.lastname: Wetters
authors.forename: Qais
authors.initials: Q
authors.lastname: Naziri
authors.forename: Susan
authors.initials: S
authors.lastname: Odum
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Fehring
authors.forename: Michael A
authors.initials: MA
authors.lastname: Mont
authors.forename: Terence J
authors.initials: TJ
authors.lastname: Gioe
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Della Valle
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects* / Q000706:statistics & numerical data; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000453:epidemiology* / Q000209:etiology; D018570:Risk Assessment; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: comorbidities; outcomes; periprosthetic joint infection; total hip arthroplasty