title: Remarkable anti-breast cancer activity of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines.
abstract: A novel series of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines is synthesized by base catalyzed cyclocondensation between ferrocenyl chalcones and amidines. The structures of synthesized compounds were established on the basis of (1)H NMR, (13)C NMR, FTIR spectroscopy as well as by mass spectrometry. The compounds were evaluated for in vitro anticancer activity. The most active compounds from the series displayed GI50 value equal to doxorubicin against the strain of human breast cancer cell line MDA-MB-435.
authors.affiliation: Department of Chemistry, Shivaji University, Kolhapur 416004, M.S., India.
authors.forename: Jagannath
authors.initials: J
authors.lastname: Jadhav
authors.forename: Aarti
authors.initials: A
authors.lastname: Juvekar
authors.forename: Rajanikant
authors.initials: R
authors.lastname: Kurane
authors.forename: Sharanabasappa
authors.initials: S
authors.lastname: Khanapure
authors.forename: Rajashri
authors.initials: R
authors.lastname: Salunkhe
authors.forename: Gajanan
authors.initials: G
authors.lastname: Rashinkar
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005296:Ferrous Compounds / Q000737:chemistry*; D006801:Humans; D000075163:Metallocenes; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C586280:1,4-dihydropyrimidine; D000970:Antineoplastic Agents; D005296:Ferrous Compounds; D000075163:Metallocenes; D011743:Pyrimidines; C004998:ferrocene
keywords: 1,4-Dihydropyrimidines; Amidines; Anti breast cancer activity; Ferrocenyl chalcones; Ferrrocene