title: Correlation between number of renal cysts and aortic circumferences measured using autopsy material.
abstract: Although the presence of renal cysts has been reported to be associated with aortic aneurysm or dissection by imaging studies, an autopsy study has not been performed. Therefore, in our institute, recent consecutive adult autopsy cases (n=108, 64 males and 44 females) were reviewed. The circumferences and atherosclerosis ratios of both thoracic and abdominal aorta were individually measured and graded. The number of renal cysts was scored and graded. Age of subjects along with histories of smoking, hypertension, and diabetes mellitus were confirmed. Multiple linear regression analyses demonstrated that severity of atherosclerosis and the number of renal cysts were correlated with thoracic aortic circumference, while only the number of renal cysts was correlated with abdominal aortic circumference (p<0.05), which was more predominant in female subjects (p<0.05). Microscopically, significantly more dilated renal tubules (by Student's t-test, p<0.05) along with decreased stainability of basement membrane by Periodic acid-Schiff staining and immunostaining of type IV collagen were noted in background renal tissues in cases with numerous renal cysts than in age- and sex-matched controls without renal cysts (n=10 vs. 10). The present study suggests that a syndrome that affects both aorta and renal tubules may exist.
authors.affiliation: Department of Molecular Pathology, Tokyo Medical University, Japan. Electronic address: akurata@ks.kyorin-u.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kurata
authors.forename: Shigeru
authors.initials: S
authors.lastname: Inoue
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Ohno
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Nakatsubo
authors.forename: Kengo
authors.initials: K
authors.lastname: Takahashi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ito
authors.forename: Kenta
authors.initials: K
authors.lastname: Kawasaki
authors.forename: Reiji
authors.initials: R
authors.lastname: Kokubo
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakai
authors.forename: Jun
authors.initials: J
authors.lastname: Ubukata
authors.forename: Shuya
authors.initials: S
authors.lastname: Matsubara
authors.forename: Ryu
authors.initials: R
authors.lastname: Muraoka
authors.forename: Jun
authors.initials: J
authors.lastname: Yamazaki
authors.forename: Takao
authors.initials: T
authors.lastname: Hirose
authors.forename: Mayuko
authors.initials: M
authors.lastname: Hojo
authors.forename: Eri
authors.initials: E
authors.lastname: Watanabe
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kuroda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001012:Aorta, Abdominal / Q000473:pathology*; D001013:Aorta, Thoracic / Q000473:pathology*; D001018:Aortic Diseases / Q000473:pathology*; D050197:Atherosclerosis / Q000473:pathology*; D001344:Autopsy; D001485:Basement Membrane / Q000737:chemistry / Q000473:pathology; D016022:Case-Control Studies; D024062:Collagen Type V / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000737:chemistry / Q000473:pathology*; D052177:Kidney Diseases, Cystic / Q000378:metabolism / Q000473:pathology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D024062:Collagen Type V
keywords: Aneurysm; Aorta; Autopsy; Basement membrane; Renal cyst