title: Chemical approach for interconversion of (S)- and (R)-α-amino acids.
abstract: Here we report a general method for the preparation of unnatural (R)-α-amino acids via complexation of α-(phenyl)ethylamine derived chiral reagent (S)- with various (S)-α-amino acids. The reactions proceed with synthetically useful chemical yields and thermodynamically controlled diastereoselectivity. Chiral reagent (S)- can be conveniently recovered and reused without any loss of enantiomeric purity and reactivity.
authors.affiliation: Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, 20018 San Sebastián, Spain.
authors.forename: Alexander E
authors.initials: AE
authors.lastname: Sorochinsky
authors.forename: Hisanori
authors.initials: H
authors.lastname: Ueki
authors.forename: José Luis
authors.initials: JL
authors.lastname: Aceña
authors.forename: Trevor K
authors.initials: TK
authors.lastname: Ellis
authors.forename: Hiroki
authors.initials: H
authors.lastname: Moriwaki
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Sato
authors.forename: Vadim A
authors.initials: VA
authors.lastname: Soloshonok
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D010627:Phenethylamines / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D007202:Indicators and Reagents; D010627:Phenethylamines