title: Chemoradiation for definitive, preoperative, or postoperative therapy of locally advanced non-small cell lung cancer.
abstract: Over the last few decades, the integration of chemotherapy and radiation has played a crucial role in the management of locally advanced non-small cell lung cancer (NSCLC). Locally advanced NSCLC is a very heterogeneous disease. Because of this heterogeneity, advanced NSCLC can be managed in various ways depending on the bulk of disease, the comorbidities of the patient, and the expertise and resources of the treating physicians and facilities. This review describes the evolution of current treatment strategies and predicted future changes for the management of locally advanced NSCLC.
authors.affiliation: University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA. jfeliciano@umm.edu
authors.forename: Josephine
authors.initials: J
authors.lastname: Feliciano
authors.forename: Steven
authors.initials: S
authors.lastname: Feigenberg
authors.forename: Minesh
authors.initials: M
authors.lastname: Mehta
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000628:therapy*; D059186:Chemoradiotherapy, Adjuvant; D002986:Clinical Trials as Topic; D019583:Dose Fractionation, Radiation; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000628:therapy*; D058990:Molecular Targeted Therapy; D011184:Postoperative Period; D057234:Preoperative Period; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents