title: Chromatin insulators: linking genome organization to cellular function.
abstract: A growing body of evidence suggests that insulators have a primary role in orchestrating the topological arrangement of higher-order chromatin architecture. Insulator-mediated long-range interactions can influence the epigenetic status of the genome and, in certain contexts, may have important effects on gene expression. Here we discuss higher-order chromatin organization as a unifying mechanism for diverse insulator actions across the genome.
authors.affiliation: Department of Biology, Emory University, Atlanta, GA 30322, USA.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Phillips-Cremins
authors.forename: Victor G
authors.initials: VG
authors.lastname: Corces
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000235:genetics; D000076246:CCCTC-Binding Factor; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D016678:Genome / Q000235:genetics*; D006801:Humans; D038101:Insulator Elements / Q000235:genetics*; D008957:Models, Genetic; D011485:Protein Binding; D012097:Repressor Proteins / Q000378:metabolism
chemical_list: D000076246:CCCTC-Binding Factor; C000619697:CTCF protein, human; D002843:Chromatin; D012097:Repressor Proteins