title: [Application of network analysis in diseases and drug studies].
abstract: A disease is rarely caused by a single virulence gene, but by an imbalanced regulatory network arising from dysfunction of multiple genes or their products. However, drugs intervene the occurrence and development of a disease by acting on multiple target points in the disease network and making a synergy effect on each target point, in order to achieve the therapeutic effect. Unlike traditional approaches focusing on a single molecule or pathway, network analysis with high-throughput data provides a new perspective for studying disease pathobiology and pharmacological mechanisms, and brings forth new ideas for multi-component and multi-target-point pharmacologic mechanisms of traditional Chinese medicines, in three aspects-establishment of relevant disease and drug network, network decomposition, and biological significant of sub-network.
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. fanok77@126.com
authors.forename: Yin-Ying
authors.initials: YY
authors.lastname: Chen
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
mesh_terms: D019295:Computational Biology / Q000379:methods*; D004194:Disease; D004358:Drug Therapy / Q000379:methods*; D006801:Humans; D008516:Medicine, Chinese Traditional; D010600:Pharmacology / Q000379:methods*