title: A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation.
abstract: High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder(MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear. Twelve healthy participants received 1Hz, 2Hz, and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110% of resting motor threshold with a 25 second inter-train interval. Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response. These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS.
authors.affiliation: Monash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Melbourne, Victoria, Australia.
authors.forename: Ting T
authors.initials: TT
authors.lastname: Cao
authors.forename: Richard H
authors.initials: RH
authors.lastname: Thomson
authors.forename: Neil W
authors.initials: NW
authors.lastname: Bailey
authors.forename: Nigel C
authors.initials: NC
authors.lastname: Rogasch
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Segrave
authors.forename: Jerome J
authors.initials: JJ
authors.lastname: Maller
authors.forename: Zafiris J
authors.initials: ZJ
authors.lastname: Daskalakis
authors.forename: Paul B
authors.initials: PB
authors.lastname: Fitzgerald
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood; D017397:Prefrontal Cortex / Q000098:blood supply* / Q000502:physiology*; D019265:Spectroscopy, Near-Infrared; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Brain stimulation; Cortical blood flow; Dorsolateral prefrontal cortex; Oxygenated hemoglobin; Transcranial magnetic stimulation