title: Modernized low pressure carbonylation methods in batch and flow employing common acids as a CO source.
abstract: Carbonylation reactions, such as Heck, Sonogashira, and radical carbonylations, were successfully carried out in a "two-chamber reactor" where carbon monoxide was produced ex situ by the Morgan reaction (dehydration of formic acid by sulfuric acid). By a subsequent application in a microflow system using a "tube-in-tube" reactor where gas-permeable Teflon AF2400 was used as the inner tube, it is demonstrated that formic acid/sulfuric acid can be employed concomitantly with an amine base such as triethylamine in the Heck aminocarbonylation of aryl iodide.
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
authors.forename: Célia
authors.initials: C
authors.lastname: Brancour
authors.forename: Takahide
authors.initials: T
authors.lastname: Fukuyama
authors.forename: Yu
authors.initials: Y
authors.lastname: Mukai
authors.forename: Troels
authors.initials: T
authors.lastname: Skrydstrup
authors.forename: Ilhyong
authors.initials: I
authors.lastname: Ryu
mesh_terms: D002248:Carbon Monoxide / Q000737:chemistry*; D005021:Ethylamines / Q000737:chemistry*; D005561:Formates / Q000737:chemistry*; D011138:Polytetrafluoroethylene / Q000737:chemistry; D011312:Pressure; D013464:Sulfuric Acids / Q000737:chemistry*
chemical_list: D005021:Ethylamines; D005561:Formates; D013464:Sulfuric Acids; C030544:formic acid; D002248:Carbon Monoxide; D011138:Polytetrafluoroethylene; C033158:sulfuric acid; C016162:triethylamine