title: Assessment of cardiac volumes using an isotropic whole-heart dual cardiac phase sequence in pediatric patients.
abstract: OBJECTIVE
  To evaluate the accuracy of a three-dimensional dual phase (3D DP) whole-heart technique for cardiac volumetric assessment in pediatric patients with cardiac abnormalities.
  
  
  METHODS
  The institutional approved this study, and informed consent was obtained from patients or their guardians. This prospective study involved 31 pediatric patients (mean age, 7.9 years; range, 15 days to 15 years) for the assessment of cardiac abnormalities using cardiovascular MR. A standard protocol was performed for assessing cardiac anatomy and function. For evaluating the 3D DP technique, statistical comparison with a 2D cine multi-slice technique (2D steady-state free-precession [SSFP]) was performed using linear regression, intraclass correlation coefficient, and Bland Altman plots.
  
  
  RESULTS
  Left (LV) and right (RV) ventricular cardiac volumes obtained with the 3D DP technique were in strong agreement with those obtained with the 2D SSFP technique for small and large ventricular volumes. The intraclass correlation coefficients (ICC) between both techniques were 0.992 for the LV end-diastolic volume (EDV), 0.983 for the LV end-systolic volume (ESV), 0.952 for the LV-systolic volume (SV), 0.992 for the RV-EDV, 0.992 for the RV-ESV, 0.928 for the RV-SV. Interobserver analysis indicated good reproducibility for both the 2D SSFP and the 3D DP techniques.
  
  
  CONCLUSIONS
  The 3D DP technique provides as accurate cardiac volumes as the 2D SSFP technique in the pediatric population, but with the added benefits of easier data acquisition and detailed anatomical information of the whole heart and great vessels in a single free-breathing scan.
authors.affiliation: Fundación Instituto de Alta Tecnología Medica, Medellin, Colombia.
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Delgado
authors.forename: Pedro
authors.initials: P
authors.lastname: Abad
authors.forename: Simon
authors.initials: S
authors.lastname: Rascovsky
authors.forename: Victor
authors.initials: V
authors.lastname: Calvo
authors.forename: Gabriel
authors.initials: G
authors.lastname: Castrillon
authors.forename: Gerald
authors.initials: G
authors.lastname: Greil
authors.forename: Sergio
authors.initials: S
authors.lastname: Uribe
mesh_terms: D000293:Adolescent; D002306:Cardiac Volume / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003287:Contrast Media; D005260:Female; D006330:Heart Defects, Congenital / Q000175:diagnosis*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007223:Infant; D007231:Infant, Newborn; D016014:Linear Models; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D011446:Prospective Studies; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media
keywords: 3D dual phase; cardiac MR; cardiac volumetric assessment; congenital heart disease; pediatric