title: Early changes of abdominal adiposity detected with weekly dual bioelectrical impedance analysis during calorie restriction.
abstract: OBJECTIVE
  To elucidate early change of intra-abdominal fat in response to calorie restriction in patients with obesity by weekly evaluation using a dual bioelectrical impedance analysis (Dual BIA) instrument.
  
  
  METHODS
  For 67 Japanese patients with obesity, diabetes, or metabolic syndrome, intra-abdominal fat area (IAFA), initially with both Dual BIA and computed tomography (CT), and in subsequent weeks of calorie restriction, with Dual BIA were measured.
  
  
  RESULTS
  IAFA by Dual BIA (Dual BIA-IAFA) correlated well with IAFA by CT (CT-IAFA) in obese patients (r = 0.821, P < .0001, n = 67). Ten males and 9 females (age 49.0 ± 14.4 years, BMI 33.2 ± 7.3 kg/m2) lost more than 5% of baseline body weight (BW) in 3 weeks, and their Dual BIA-IAFA, BW, and WC decreased by 18.9%, 5.3%, and 3.8%, respectively (P < .05, ANCOVA).
  
  
  CONCLUSIONS
  Dual BIA instrument could detect the weekly change of Dual BIA-IAFA under calorie restriction in obese patients and demonstrated a substantially larger change of IAFA compared with changes of BW and WC in early weeks. This observation corroborates the significance of evaluating IAFA as a biomarker for obesity, and indicates the clinical usefulness of the Dual BIA instrument.
authors.affiliation: Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan.
authors.forename: Midori
authors.initials: M
authors.lastname: Ida
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hirata
authors.forename: Shinji
authors.initials: S
authors.lastname: Odori
authors.forename: Eisaku
authors.initials: E
authors.lastname: Mori
authors.forename: Eri
authors.initials: E
authors.lastname: Kondo
authors.forename: Junji
authors.initials: J
authors.lastname: Fujikura
authors.forename: Toru
authors.initials: T
authors.lastname: Kusakabe
authors.forename: Ken
authors.initials: K
authors.lastname: Ebihara
authors.forename: Kiminori
authors.initials: K
authors.lastname: Hosoda
authors.forename: Kazuwa
authors.initials: K
authors.lastname: Nakao
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D031204:Caloric Restriction; D003920:Diabetes Mellitus / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D017097:Electric Impedance; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D007564:Japan; D008297:Male; D024821:Metabolic Syndrome / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000178:diet therapy / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed; D055105:Waist Circumference / Q000502:physiology*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D015415:Biomarkers