title: [Regional and peripheral arterial stiffness measured by pOpmetre® in patients with Cvx risk factor, link with carotid plaques].
abstract: OBJECTIVE
  Aortic stiffness is a functional and structural consequence of ageing and arteriosclerosis. Regional arterial stiffness can be easily evaluated using pOpmetre(®) (Axelife SAS, France). This new technique assesses the pulse wave transit time (TT) between the finger (TTf) and the toe (TTt). Based on height chart, regional pulse wave velocity (PWV) between the toe and the finger can be estimated (PWVtf). pOpscore(®) index is also calculated as the ratio between PWVtoe and PWVfinger and can be considered as a peripheral vascular stiffness index. The aim of the study was to evaluate the relationship between pOpmetre(®) indices and the presence of carotid plaques in a population with cardiovascular risk factors.
  
  
  METHODS
  In 77 consecutive patients recruited for a vascular screening for atherosclerosis (46 men aged 54 ± 2 years; 31 women aged 49 ± 3 years; ns), the difference between TTt and TTf (called Dt-f), the regional pulse wave velocity between the toe and the finger (PWVtf = constant × height/Dt-fm/s) and pOpscore(®) were measured by pOpmetre(®). Presence of carotid plaques was assessed using ultrasound imaging. The local aortic stiffness (AoStiff) was evaluated by the Physioflow(®) system.
  
  
  RESULTS
  No difference was found between patients with or without carotid plaques (n=25 versus 52) for Ankle-Brachial Pressure Index (ABPI: 1.15 ± 0.04 versus 1.12 ± 0.03), nor for diastolic or systolic blood pressure (87 ± 3 versus 82 ± 2; 137 ± 3 versus 132 ± 2 mmHg). The first group was older than the second (59 ± 2 versus 49 ± 2 years, P<0.002) with a larger intimae media thickness (0.69 ± 0.02 versus 0.63 ± 0.01 mm, P<0.004), a higher AoStiff (10.4 ± 0.7 versus 8.2 ± 0.5m/s, P<0.02), and PWVtf (14.3 ± 1.0 versus 10.7 ± 0.7 m/s, P<0.004) and a shorter Dt-f (57.9 ± 5.1 versus 73.5 ± 3.5 ms, P<0.01). PWVtf (r(2)=0.49, P<0.0001) and Dt-f (r(2)=0.54, P<0.0001) correlated with age. A significant difference in pOpscore(®) index was observed between both groups (1.51 ± 0.3 versus 1.41 ± 0.2, P<0.006).
  
  
  CONCLUSIONS
  Our results show a significant arterial stiffness indices measured by pOpmetre(®) in patients with and without carotid plaques.
authors.affiliation: Département de médecine gériatrique, hôpital universitaire, place Alexis-Ricordeau, 44093 Nantes cedex 1, France. magid.hallab@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Hallab
authors.forename: M
authors.initials: M
authors.lastname: Collette
authors.forename: C
authors.initials: C
authors.lastname: Terrier-Barbeau
authors.forename: M
authors.initials: M
authors.lastname: Legrand
authors.forename: P-H
authors.initials: PH
authors.lastname: Ducluzeau
authors.forename: G
authors.initials: G
authors.lastname: Berrut
authors.forename: G
authors.initials: G
authors.lastname: Lefthériotis
mesh_terms: D002318:Cardiovascular Diseases / Q000517:prevention & control; D059168:Carotid Intima-Media Thickness; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005385:Fingers; D006801:Humans; D008297:Male; D008365:Manometry / Q000295:instrumentation*; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D063177:Pulse Wave Analysis; D012307:Risk Factors; D014034:Toes; D059289:Vascular Stiffness
keywords: Arterial stiffness; Cardiovascular risk factor; Carotid plaques; Facteur de risque cardiovasculaire; Plaques carotidiennes; Pulse wave velocity; Rigidité artérielle; Temps de transit; Transit time; Vitesse de l’onde de pouls