title: Heparin-induced thrombocytopenia with abdominal aortic stent-graft acute thrombosis.
abstract: We report a case of heparin-induced thrombocytopenia in a patient on low molecular weight heparin bridge therapy who developed acute abdominal aortic stent-graft thrombosis 1 week after uncomplicated endovascular abdominal aortic aneurysm repair. The diagnosis was confirmed by a computed tomographic scan of the abdomen. The patient was successfully treated by conversion to open repair. The postoperative course was marked by subacute left limb ischemia related to an in vivo cross-reactivity of danaparoid with the heparin immune complex. To our knowledge, this is the first case report of heparin-induced thrombocytopenia with acute abdominal aortic stent-graft thrombosis.
authors.affiliation: Department of Vascular and Thoracic Surgery, Arnaud de Villeneuve Hospital, Montpellier, France. ludoviccanaud@hotmail.com
authors.forename: Ludovic
authors.initials: L
authors.lastname: Canaud
authors.forename: Kheira
authors.initials: K
authors.lastname: Hireche
authors.forename: Charles
authors.initials: C
authors.lastname: Marty-Ané
authors.forename: Pierre
authors.initials: P
authors.lastname: Alric
mesh_terms: D000208:Acute Disease; D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000601:surgery*; D020878:Device Removal / Q000379:methods*; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D017131:Thrombectomy / Q000379:methods*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D018616:Ultrasonography, Doppler, Duplex
chemical_list: D000925:Anticoagulants; D006493:Heparin