title: Development of central diabetes insipidus following electroconvulsive therapy: results of a prospective pilot study.
abstract: OBJECTIVE
  The objective of this study was to examine the occurrence of laboratory abnormalities and symptoms of central diabetes insipidus (CDI) in patients receiving acute electroconvulsive therapy (ECT) series.
  
  
  METHODS
  We prospectively investigated adult psychiatric inpatients for objective and subjective evidence of CDI at baseline and after their sixth ECT.
  
  
  RESULTS
  Although participants did not report any CDI symptoms, two thirds had clinically important decreases in urine osmolality (>200 mOsm/kg), and two thirds had serum sodium increases of 5 mmol/L following exposure to ECT.
  
  
  CONCLUSIONS
  Our findings suggest that objective evidence of CDI can occur following the administration of ECT series, even in the absence of symptomatic complaints.
authors.affiliation: McGill University, Montreal, Quebec, Canada.
authors.forename: Soumia Imène
authors.initials: SI
authors.lastname: Senouci
authors.forename: Soham
authors.initials: S
authors.lastname: Rej
authors.forename: Karl
authors.initials: K
authors.lastname: Looper
authors.forename: Marilyn
authors.initials: M
authors.lastname: Segal
mesh_terms: D000328:Adult; D000368:Aged; D020790:Diabetes Insipidus, Neurogenic / Q000209:etiology* / Q000652:urine; D004565:Electroconvulsive Therapy / Q000009:adverse effects* / Q000295:instrumentation; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010865:Pilot Projects; D011141:Polyuria / Q000209:etiology; D011446:Prospective Studies; D012964:Sodium / Q000097:blood / Q000652:urine
chemical_list: D012964:Sodium