title: Clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study.
abstract: Data demonstrating the efficacy of hyaluronic acid (HA)-based mesotherapy for skin rejuvenation are scarce. The aim of the study is to assess the efficacy of non-reticulated HA-based mesotherapy on skin elasticity and complexion radiance. 55 women with cutaneous ageing signs included in the Full Analysis Set (FAS) population blindly received intradermal micro-injections (50 × 0.02 mL) of non-cross-linked HA filler with mannitol (Glytone 1, HA concentration: 14 mg/g) in one cheek and saline physiological solution in the other according to hemifacial randomisation in 3 monthly sessions. Elasticity (E1 and E2 stiffness parameters) and dermis thickness were measured by cutometry and 20 MHz echography, before (D0) treatment and 1 (1M) and 3 months (3M) after the last injection. A trained panel blindly scored skin complexion radiance from standardised and calibrated photographs, using 100 mm analogue scales. In the FAS population, only HA filler significantly decreased E1 at 1M (-10.9 %, p = 0.026) and 3M (-10.5 %, p = 0.035) compared with D0; its effect versus the control tended to be more persistent, with a difference between treatments at 3M close to significance (p = 0.063). E2 also decreased at 1M (-8.2 %, p = 0.027 in the per protocol population, n = 53) and 3M after HA-treatment only. Dermis thickness significantly increased after HA-treatment at 1M (+3.4 %, p = 0.028) and 3M (+4 %, p = 0.008), and after control-treatment at 1M only (+2.5 %, p = 0.015). The HA filler significantly improved complexion radiance at 3M compared with the control (p = 0.012) and for 51 % of subjects, their skin status. Non-reticulated HA-based mesotherapy significantly and sustainably improves skin elasticity and complexion radiance.
authors.affiliation: Dermatologist, Bordeaux, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Baspeyras
authors.forename: Céline
authors.initials: C
authors.lastname: Rouvrais
authors.forename: Laetitia
authors.initials: L
authors.lastname: Liégard
authors.forename: Alexandre
authors.initials: A
authors.lastname: Delalleau
authors.forename: Sandrine
authors.initials: S
authors.lastname: Letellier
authors.forename: Irène
authors.initials: I
authors.lastname: Bacle
authors.forename: Laetitia
authors.initials: L
authors.lastname: Courrech
authors.forename: Pascale
authors.initials: P
authors.lastname: Murat
authors.forename: Valérie
authors.initials: V
authors.lastname: Mengeaud
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Schmitt
mesh_terms: D000328:Adult; D000368:Aged; D003357:Cosmetic Techniques; D004548:Elasticity / Q000187:drug effects*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects* / Q000627:therapeutic use*; D057748:Mesotherapy / Q000379:methods*; D008875:Middle Aged; D012038:Regeneration / Q000187:drug effects; D012060:Rejuvenation; D012867:Skin / Q000187:drug effects; D015595:Skin Aging / Q000187:drug effects*; D017592:Skin Care; D012879:Skin Physiological Phenomena / Q000187:drug effects
chemical_list: D006820:Hyaluronic Acid