title: A generic strategy for pharmacological caging of growth factors for tissue engineering.
abstract: The caging of small molecules has revolutionized biological research by providing a means to regulate a wide range of processes. Here we report on a generic pharmacological method to cage proteins in a similar fashion. The present approach is of value in both fundamental and applied research, e.g. in tissue engineering.
authors.affiliation: Faculty of Biology, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Karlsson
authors.forename: Philipp S
authors.initials: PS
authors.lastname: Lienemann
authors.forename: Natallia
authors.initials: N
authors.lastname: Sprossmann
authors.forename: Katharina
authors.initials: K
authors.lastname: Heilmann
authors.forename: Tilman
authors.initials: T
authors.lastname: Brummer
authors.forename: Matthias P
authors.initials: MP
authors.lastname: Lutolf
authors.forename: Martin
authors.initials: M
authors.lastname: Ehrbar
authors.forename: Wilfried
authors.initials: W
authors.lastname: Weber
mesh_terms: D000469:Alkaline Phosphatase / Q000737:chemistry; D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D027081:DNA Gyrase / Q000737:chemistry; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology; D057809:HEK293 Cells; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000737:chemistry; D007074:Immunoglobulin G / Q000737:chemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage* / Q000737:chemistry*; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000502:physiology; D051379:Mice; D009675:Novobiocin / Q000737:chemistry; D023822:Tissue Engineering
chemical_list: D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D036341:Intercellular Signaling Peptides and Proteins; D009675:Novobiocin; D000469:Alkaline Phosphatase; D027081:DNA Gyrase