title: Serum fetuin-A levels related with microalbuminuria in diet-induced obese rats.
abstract: The aim of the study was to investigate the association between elevated serum fetuin-A and increased urine albumin excretion in obese rats, and whether increased urine albumin excretion was modified by improving hepatic steatosis and lipid metabolism disorder. Male Wistar rats 4 weeks in age were randomly divided into three groups and fed with normal chow (control group), high-fat chow (obesity group), or high-fat chow plus fenofibrate (fenofibrate group). After 24 weeks, both body weight and visceral fat/body weight ratio in obese rats were higher than in controls. A difference in serology markers and pathology associated with hepatic steatosis was also found among the three groups. Serum fetuin-A and the expression of NF- κ B in the liver were increased, while serum adiponectin was decreased in obese rats in comparison to controls (P < 0.01). Urinary albumin/creatinine ratio (ACR) was increased in the obesity group compared to controls (P < 0.01). The fenofibrate intervention reduced serum fetuin-A and NF- κ B expression in the liver and increased serum adiponectin compared to obese rats and was accompanied by decrease in ACR. A positive correlation was found between ACR and fetuin-A (r = 0.602, P < 0.01), and a negative correlation was found between ACR and adiponectin (r = -0.635, P < 0.01). We conclude that elevated fetuin-A levels are associated with microalbuminuria in obese rats, and abnormal albuminuria is reversible by improving hepatic steatosis.
authors.affiliation: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Li
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Sun
authors.forename: Yerong
authors.initials: Y
authors.lastname: Yu
mesh_terms: D052242:Adiponectin / Q000097:blood; D000419:Albuminuria / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D003404:Creatinine / Q000652:urine; D059305:Diet, High-Fat; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D016328:NF-kappa B / Q000096:biosynthesis / Q000378:metabolism; D009765:Obesity / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D044967:Serum / Q000378:metabolism; D060749:alpha-2-HS-Glycoprotein / Q000096:biosynthesis* / Q000378:metabolism
chemical_list: D052242:Adiponectin; D016328:NF-kappa B; D060749:alpha-2-HS-Glycoprotein; D003404:Creatinine