title: Ethical use of antiretroviral resources for HIV prevention in resource poor settings.
abstract: The effectiveness of antiretroviral regimes (ARVs) to reduce risk of HIV transmission from mother to child and as post-exposure prophylaxis has been known for almost two decades. Recent research indicates ARVs can also reduce the risk of HIV transmission via sexual intercourse in two other ways. With pre-exposure prophylaxis (PrEP), ARVs are used to reduce risk of HIV acquisition among persons who are HIV negative and significantly exposed to the virus. With treatment as prevention (TasP), ARVs are used to reduce risk of HIV transmission from persons who are already HIV positive. The development of these new prevention strategies raises a rationing problem: given the chronic shortage of ARVs for HIV-infected persons in need of treatment, is it ethically justified to allocate ARVs for PrEP and/or TasP? This article examines the intuitively appealing view that allocation of ARVs for treatment should be the highest priority, the use of ARVs for TasP should be a secondary priority, and that utilizing ARVs for PrEP would be unethical. I will argue that selective, evidence-based allocation of ARVs for prevention in certain cases could be ethically justified even when there is insufficient anti-retroviral access for all those needing it for treatment.
authors.affiliation: University of North Carolina – Social Medicine, 333D MacNider Building, Chapel Hill, NC 27599, USA. stuart_rennie@med.unc.edu
authors.forename: Stuart
authors.initials: S
authors.lastname: Rennie
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D003075:Coitus; D003906:Developing Countries; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000517:prevention & control* / Q000635:transmission; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000188:drug therapy; D015276:Health Care Rationing / Q000941:ethics*; D006292:Health Priorities / Q000941:ethics*; D006295:Health Resources / Q000706:statistics & numerical data; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D008297:Male; D011322:Primary Prevention / Q000941:ethics* / Q000379:methods; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D044966:Anti-Retroviral Agents
keywords: HIV/AIDS; Prevention; Rationing; antiretroviral therapy; developing world; resource allocation; treatment