title: An assessment of the shared allelic architecture between type II diabetes and prostate cancer.
abstract: BACKGROUND
  To determine whether the alleles that influence type II diabetes risk and glycemic traits also influence prostate cancer risk.
  
  
  METHODS
  We used a multiple single-nucleotide polymorphisms (SNP) genotypic risk score to assess the average effect of alleles that increase type II diabetes risk or worsen glycemic traits on risk of prostate cancer in 19,662 prostate cancer cases and 19,715 controls from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium and 5,504 prostate cancer cases and 5,834 controls from the Cancer Research UK (CRUK) prostate cancer study.
  
  
  RESULTS
  Calculating the average additive effect of type II diabetes or glycemic trait risk alleles on prostate cancer risk using a logistic model revealed no evidence of a shared allelic architecture between type II diabetes, or worsened glycemic status, with prostate cancer risk [OR for type II diabetes alleles: 1.00 (P = 0.58), fasting glycemia alleles: 1.00 (P = 0.67), HbA1c alleles: 1.00 (P = 0.93), 2-hour OGTT alleles: 1.01 (P = 0.14), and HOMA-B alleles: 0.99 (P = 0.57)].
  
  
  CONCLUSIONS
  Using genetic data from large consortia, we found no evidence for a shared genetic etiology of type II diabetes or glycemic risk with prostate cancer.
  
  
  CONCLUSIONS
  Our results showed that alleles influencing type II diabetes and related glycemic traits were not found to be associated with the risk of prostate cancer.
authors.affiliation: Department of Medicine, Division of Endocrinology, Jewish General Hospital, Montreal, Québec, Canada.
authors.forename: Oriana Hoi Yun
authors.initials: OH
authors.lastname: Yu
authors.forename: William D
authors.initials: WD
authors.lastname: Foulkes
authors.forename: Zari
authors.initials: Z
authors.lastname: Dastani
authors.forename: Richard M
authors.initials: RM
authors.lastname: Martin
authors.forename: Rosalind
authors.initials: R
authors.lastname: Eeles
authors.forename: J Brent
authors.initials: JB
authors.lastname: Richards
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors