title: Monitored daily ambulatory activity, inflammation, and oxidative stress in patients with claudication.
abstract: We determined the association between daily ambulatory activity and markers of inflammation and oxidative stress in patients with peripheral artery disease (PAD) and claudication. Patients with PAD (n = 134) limited by claudication were studied. Patients took 3275 ± 1743 daily strides for 273 ± 112 minutes each day, and their average daily cadence was 11.7 ± 2.7 strides/min. High-sensitivity C-reactive protein was significantly and negatively associated with the total number of daily strides (P < .001), total daily ambulatory time (P < .01), peak activity index (P < .01), daily average cadence (P < .05), and the maximum cadences for 60 minutes (P < .05), 30 minutes (P < .05), 20 minutes (P < .05), and 5 minutes (P < .01). Oxidized low-density lipoprotein and soluble vascular cell adhesion molecule 1 were not significantly associated with any of the ambulatory measures (P > .05). We conclude that higher levels of community-based, daily ambulatory activity are associated with lower levels of inflammation but are not associated with markers of oxidative stress.
authors.affiliation: Donald W. Reynolds Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA Veterans Affairs Medical Center, Oklahoma City, OK, USA andrew-gardner@ouhsc.edu.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Gardner
authors.affiliation: Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Donald E
authors.initials: DE
authors.lastname: Parker
authors.affiliation: Donald W. Reynolds Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Polly S
authors.initials: PS
authors.lastname: Montgomery
authors.affiliation: General Internal Medicine Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Steve M
authors.initials: SM
authors.lastname: Blevins
authors.affiliation: CMRI Diabetes and Metabolic Research Program, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: April M
authors.initials: AM
authors.lastname: Teague
authors.affiliation: Cardiovascular Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Ana I
authors.initials: AI
authors.lastname: Casanegra
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D005080:Exercise Test; D005260:Female; D005684:Gait / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007383:Intermittent Claudication / Q000097:blood / Q000503:physiopathology*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D058729:Peripheral Arterial Disease / Q000097:blood / Q000503:physiopathology; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood; D016138:Walking / Q000502:physiology*
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; D019010:Vascular Cell Adhesion Molecule-1; D002097:C-Reactive Protein
keywords: C-reactive protein; claudication; oxidized low-density lipoprotein; peripheral artery disease