title: [Study on cephalosporins with terahertz time-domain spectroscopy technique].
abstract: Terahertz Time-Domain Spectroscopy (THz-TDS) technique has a wide range of applications in substances identification and quantitative analysis. In the present paper, we report absorption spectra and index of refraction of 14 kinds of pure cephalosporins in 0.2-2.6 THz, in which eight kinds have apparent absorption peaks, while the others have different index of refraction. Based on these results, different kinds of antibiotics can be identified. Besides, according to THz absorption spectra of both pure sample and real pills we calculated the contents of cefixime in the two pills produced by two manufacturers. Compared with the contents marked on the package, relative errors are 9.38% and 0.92%, respectively. The results manifest that THz-TDS technique is reliable and promising in medicine detection.
authors.affiliation: Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Department of Physics, Capital Normal University, Beijing 100048, China. alicezm2005@gmail.com
authors.forename: Man
authors.initials: M
authors.lastname: Zhang
authors.forename: Si-Yuan
authors.initials: SY
authors.lastname: Zhu
authors.forename: Qing-Mei
authors.initials: QM
authors.lastname: Li
authors.forename: Jing-Ling
authors.initials: JL
authors.lastname: Shen
mesh_terms: D020682:Cefixime / Q000737:chemistry; D002511:Cephalosporins / Q000737:chemistry*; D012031:Refractometry; D055068:Terahertz Spectroscopy / Q000379:methods*
chemical_list: D002511:Cephalosporins; D020682:Cefixime