title: A genome-wide resource of cell cycle and cell shape genes of fission yeast.
abstract: To identify near complete sets of genes required for the cell cycle and cell shape, we have visually screened a genome-wide gene deletion library of 4843 fission yeast deletion mutants (95.7% of total protein encoding genes) for their effects on these processes. A total of 513 genes have been identified as being required for cell cycle progression, 276 of which have not been previously described as cell cycle genes. Deletions of a further 333 genes lead to specific alterations in cell shape and another 524 genes result in generally misshapen cells. Here, we provide the first eukaryotic resource of gene deletions, which describes a near genome-wide set of genes required for the cell cycle and cell shape.
authors.affiliation: Cell Cycle Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Hayles
authors.forename: Valerie
authors.initials: V
authors.lastname: Wood
authors.forename: Linda
authors.initials: L
authors.lastname: Jeffery
authors.forename: Kwang-Lae
authors.initials: KL
authors.lastname: Hoe
authors.forename: Dong-Uk
authors.initials: DU
authors.lastname: Kim
authors.forename: Han-Oh
authors.initials: HO
authors.lastname: Park
authors.forename: Silvia
authors.initials: S
authors.lastname: Salas-Pino
authors.forename: Christian
authors.initials: C
authors.lastname: Heichinger
authors.forename: Paul
authors.initials: P
authors.lastname: Nurse
mesh_terms: D002453:Cell Cycle / Q000235:genetics*; D019295:Computational Biology; D017353:Gene Deletion; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D018816:Genes, cdc; D016681:Genome, Fungal; D006801:Humans; D016296:Mutagenesis; D010641:Phenotype; D012568:Schizosaccharomyces / Q000166:cytology* / Q000235:genetics*; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics
chemical_list: D029702:Schizosaccharomyces pombe Proteins
keywords: cell cycle; cell shape; fission yeast; genome-wide gene deletion resource