title: Cytokine regulation of the epidermal barrier.
abstract: Studies published in recent years have highlighted the role of epidermal barrier defects in both atopic skin disease and the development of broader allergic manifestations. While genetic determinants of barrier function are important, it is clear that local acquired effects are also involved in disease pathogenesis. In this review, we aimed to summarize the known influences of cytokines abundantly expressed during atopic skin disease on components of epidermal barrier integrity and function.
authors.affiliation: MRC Human Immunology Unit, University of Oxford, John Radcliffe Hospital, Oxford, UK.
authors.forename: D
authors.initials: D
authors.lastname: Gutowska-Owsiak
authors.forename: G S
authors.initials: GS
authors.lastname: Ogg
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism*; D004817:Epidermis / Q000276:immunology* / Q000378:metabolism* / Q000382:microbiology; D000091344:Filaggrin Proteins; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D007365:Intercellular Junctions / Q000502:physiology; D007381:Intermediate Filament Proteins / Q000378:metabolism; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism; D050356:Lipid Metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D015398:Signal Transduction; D012867:Skin / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D014867:Water / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D016207:Cytokines; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D014867:Water; D010447:Peptide Hydrolases