title: Slipped capital femoral epiphysis associated with vitamin D deficiency: a series of 15 cases.
abstract: Slipped capital femoral epiphysis (SCFE) is uncommon in India and we routinely look for associated metabolic or endocrine abnormalities. In this study we investigated a possible association between vitamin D deficiency and SCFE. All children presenting with SCFE during the study period had their 25-hydroxyvitamin D levels measured as part of an overall metabolic, renal and endocrine status evaluation, which included measurement of body mass index (BMI). Vitamin D status was compared with age-, gender- and habitat-matched controls with acute trauma or sepsis presenting to our emergency department. A total of 15 children (12 boys and three girls) with a mean age of 13 years (sd 1.81; 10 to 16) presented for treatment for SCFE during a two-year period beginning in January 2010. Renal and thyroid function was within the normal range in all cases. The mean BMI was 24.9 kg/m(2) (17.0 to 33.8), which was significantly higher than that of the controls (p = 0.006). There was a statistically significant difference between the mean values of 25-hydroxyvitamin D in the children with SCFE and the controls (11.78 ng/ml (SD 5.4) versus 27.06 ng/ml (SD 5.53), respectively; p < 0.001). We concluded that, along with high BMI, there is a significant association of vitamin D deficiency and SCFE in India.
authors.affiliation: Paediatric Orthopaedic Unit, Christian Medical College, Vellore 632 004, India. madhuriwalter@cmcvellore.ac.in
authors.forename: V
authors.initials: V
authors.lastname: Madhuri
authors.forename: S K
authors.initials: SK
authors.lastname: Arora
authors.forename: V
authors.initials: V
authors.lastname: Dutt
mesh_terms: D000293:Adolescent; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D060048:Slipped Capital Femoral Epiphyses / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications* / Q000188:drug therapy
chemical_list: D050071:Bone Density Conservation Agents; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25 hydroxyvitamin D; SCFE; SUFE; Slipped upper femoral epiphysis; Vitamin D2; Vitamin D3