title: Potassium content of irradiated packed red blood cells in different storage media: is there a need for additive solution-dependent recommendations for infant transfusion?
abstract: Prevention of transfusion-associated graft versus host disease (TA-GVHD) by gamma irradiation is known to induce increased K+ in supernatant of packed red blood cells (PRBCs) stored in CPDA-1 and SAGM conservative solutions. However, no data exist for PRBCs in AS-3 medium which is considered safe for neonatal transfusion. We evaluated haemolysis and K+ release from irradiated AS-3 PRBCs and compared our results with reported data for SAGM and CPDA-1 PRBCs. Our results indicate that irradiated PRBCs stored in AS-3 after more than 7 days post-irradiation should not be used in massive and/or rapidly infused transfusions in neonates and infants.
authors.affiliation: Brugmann University Hospital Centre, Queen Fabiola University Children Hospital Blood Bank, Brussels, Belgium. Electronic address: hanane.elkenz@chu-brugmann.be.
authors.forename: H
authors.initials: H
authors.lastname: El Kenz
authors.forename: F
authors.initials: F
authors.lastname: Corazza
authors.forename: P
authors.initials: P
authors.lastname: Van Der Linden
authors.forename: S
authors.initials: S
authors.lastname: Chabab
authors.forename: C
authors.initials: C
authors.lastname: Vandenvelde
mesh_terms: D000225:Adenine / Q000494:pharmacology*; D001793:Blood Preservation; D002951:Citrates / Q000494:pharmacology*; D003451:Cryoprotective Agents / Q000494:pharmacology; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism*; D005720:Gamma Rays; D005947:Glucose / Q000494:pharmacology*; D006086:Graft vs Host Disease / Q000517:prevention & control; D006461:Hemolysis / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008353:Mannitol / Q000494:pharmacology*; D010710:Phosphates / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology*; D013997:Time Factors
chemical_list: C037839:ADSOL; C034876:CPDA solutions; D002951:Citrates; D003451:Cryoprotective Agents; D010710:Phosphates; D008353:Mannitol; D012965:Sodium Chloride; D005947:Glucose; D000225:Adenine; D011188:Potassium
keywords: AS-3 conservative solution; Packed red blood cells; Potassium; Transfusion-associated graft versus host disease