title: Impact of family history of cancer on the incidence of mutation in epidermal growth factor receptor gene in non-small cell lung cancer patients.
abstract: BACKGROUND
  Epidermal growth factor receptor (EGFR) activating mutation is an important predictive biomarker of EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC), while family history of cancer also plays an important role in the neoplasia of lung cancer. This study aimed to investigate the association between family history of cancer and EGFR mutation status in NSCLC population.
  
  
  METHODS
  From February 2008 to May 2012, 538 consecutive NSCLC patients with known EGFR mutation status were included into this study. Amplification refractory mutation system (ARMS) method was used to detect EGFR mutation. The associations between EGFR mutation and family history of cancer were evaluated using logistic regression models.
  
  
  RESULTS
  EGFR activating mutation was found in 220 patients and 117 patients had family cancer histories among first-degree relatives. EGFR mutation was more frequently detected in adenocarcinoma patients (p < 0.001), never-smoker (p < 0.001) and with family history of cancer (p = 0.031), especially who had family history of lung cancer (p = 0.008). In multivariate analysis, the association of EGFR mutation with family history of cancer also existed (p = 0.027).
  
  
  CONCLUSIONS
  NSCLC patients with family history of cancer, especially family history of lung cancer, might have a significantly higher incidence of EGFR activating mutation.
authors.affiliation: Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, No. 507 Zhengmin Road, Shanghai 200433, People's Republic of China. 2250601@qq.com
authors.forename: Yayi
authors.initials: Y
authors.lastname: He
authors.forename: Shuai
authors.initials: S
authors.lastname: Li
authors.forename: Shengxiang
authors.initials: S
authors.lastname: Ren
authors.forename: Weijing
authors.initials: W
authors.lastname: Cai
authors.forename: Xuefei
authors.initials: X
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Zhao
authors.forename: Jiayu
authors.initials: J
authors.lastname: Li
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Chen
authors.forename: Guanghui
authors.initials: G
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Fei
authors.initials: F
authors.lastname: Zhou
authors.forename: Caicun
authors.initials: C
authors.lastname: Zhou
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology* / Q000235:genetics*; D005192:Family Health; D005260:Female; D018773:Genes, erbB-1; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D059645:Mutation Rate
keywords: Epidermal growth factor receptor; Family history of cancer; Family history of lung cancer; Incidence; Mutation; Non-small cell lung cancer