title: Primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature.
abstract: BACKGROUND
  Primary adenocarcinoma of thymus is extremely rare.
  
  
  METHODS
  This is a case of primary adenocarcinoma with intestinal differentiation and focal mucin production in the thymus. Thymic cyst was associated with this tumor. Intestinal differentiation was confirmed by immunohistochemical stain with positivity for CDX-2, CK20, villin, MOC31 and focal positivity of CK7. Array comperative genomic hybridization (CGH) analysis showed a complex pattern of chromosomal imbalances including homozygous deletion at the HLA locus in chromosomal region 6p21.32.
  
  
  CONCLUSIONS
  This rare tumor shows a similar genetic aberration with other studied thymic epithelial tumors.
authors.affiliation: Department of Molecular Pathology, Dr Daneshbod Pathology Laboratory, Shiraz, Iran. y@daneshbod.com.
authors.forename: Maryam
authors.initials: M
authors.lastname: Maghbool
authors.forename: Mani
authors.initials: M
authors.lastname: Ramzi
authors.forename: Inga
authors.initials: I
authors.lastname: Nagel
authors.forename: Pablo
authors.initials: P
authors.lastname: Bejarano
authors.forename: Reiner
authors.initials: R
authors.lastname: Siebert
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Saeedzadeh
authors.forename: Yahya
authors.initials: Y
authors.lastname: Daneshbod