title: Synthesis and preliminary biological evaluation of a compound library of triazolylcyclitols.
abstract: A small library of compounds was prepared by a combination of toluene dioxygenase (TDO)-catalyzed enzymatic dihydroxylation and copper(I)-catalyzed Hüisgen cycloaddition. Some compounds were obtained by coupling an alkyne and a conduritol derivative, while more complex structures were obtained by a double Hüisgen reaction of a dialkyne and two molecules of the cyclitol. The compounds were fully characterized and subjected to preliminary biological screening.
authors.affiliation: Depto. de Química Orgánica, Facultad. de Química, Universidad de la República, UdelaR, Montevideo, Uruguay.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Carrau
authors.forename: Carine C
authors.initials: CC
authors.lastname: Drewes
authors.forename: Ana Lúcia B
authors.initials: AL
authors.lastname: Shimada
authors.forename: Ana
authors.initials: A
authors.lastname: Bertucci
authors.forename: Sandra H P
authors.initials: SH
authors.lastname: Farsky
authors.forename: Helio A
authors.initials: HA
authors.lastname: Stefani
authors.forename: David
authors.initials: D
authors.lastname: Gonzalez
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D054812:Cyclitols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D061565:Cycloaddition Reaction; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D054812:Cyclitols; D007166:Immunosuppressive Agents; D054852:Small Molecule Libraries; D014230:Triazoles