title: A-to-I RNA editing does not change with age in the healthy male rat brain.
abstract: RNA editing is a post-transcriptional process, which results in base substitution modifications to RNA. It is an important process in generating protein diversity through amino acid substitution and the modulation of splicing events. Previous studies have suggested a link between gene-specific reductions in adenosine to inosine RNA editing and aging in the human brain. Here we demonstrate that changes in RNA editing observed in humans with age are not observed during aging in healthy rats. Furthermore, we identify a conserved editing site in rats, in Cog3. We propose that either age-related changes in RNA editing are specific to primates or humans, or that they are the manifestation of disease pathology. Since rodents are often used as model organisms for studying aging, these findings demonstrate the importance of understanding species-specific differences in RNA biology during aging.
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, UK.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Holmes
authors.forename: Shona H
authors.initials: SH
authors.lastname: Wood
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Merry
authors.forename: João Pedro
authors.initials: JP
authors.lastname: de Magalhães
mesh_terms: D000225:Adenine / Q000737:chemistry*; D000375:Aging / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D017931:DNA Primers; D007288:Inosine / Q000737:chemistry*; D008297:Male; D016133:Polymerase Chain Reaction; D017393:RNA Editing; D051381:Rats
chemical_list: D017931:DNA Primers; D007288:Inosine; D000225:Adenine