title: Randomized trial on the effect of sevoflurane on polypropylene membrane oxygenator performance.
abstract: OBJECTIVE
  Volatile anesthetics have cardioprotective properties that improve clinically relevant outcomes in cardiac surgery, and can be used during cardiopulmonary bypass (CPB) through adapted calibrated vaporizers together with air and oxygen (O2). The effect of volatile agents on the membrane oxygenator is unknown. The aim of this study was to evaluate, for the first time, the performance of semiporous polypropylene membrane oxygenators after the use of sevoflurane vaporized during CPB in cardiac surgery.
  
  
  METHODS
  A prospective, randomized, controlled trial.
  
  
  METHODS
  Teaching hospital.
  
  
  METHODS
  Thirty-two consecutive patients scheduled to undergo coronary artery bypass graft with CPB.
  
  
  METHODS
  Patients were allocated randomly to receive either a volatile anesthetic (sevoflurane 1%-3%, 16 patients) or an intravenous hypnotic (midazolam, 16 patients) during CPB. After surgery, the membrane oxygenators used during CPB were tested with regard to O2 transfer, carbon dioxide transfer, and pressure drop.
  
  
  RESULTS
  The authors observed no protocol deviation or crossover. The performance of the membrane oxygenator was similar between the 2 groups, as documented by O2 transfer (55±6.4 mL/min/L in the sevoflurane group versus 57±4.7 mL/min/L in the midazolam group, p = 0.4), carbon dioxide transfer, and pressure drop.
  
  
  CONCLUSIONS
  The use of sevoflurane during CPB in cardiac surgery does not affect membrane oxygenator performance.
authors.affiliation: Dante Pazzanese Institute of Cardiology, Brazil.
authors.forename: Caetano
authors.initials: C
authors.lastname: Nigro Neto
authors.forename: Renato
authors.initials: R
authors.lastname: Arnoni
authors.forename: Bilal Smaili
authors.initials: BS
authors.lastname: Rida
authors.forename: Giovanni
authors.initials: G
authors.lastname: Landoni
authors.forename: Maria Angela
authors.initials: MA
authors.lastname: Tardelli
mesh_terms: D000368:Aged; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D001026:Coronary Artery Bypass / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D008875:Middle Aged; D010107:Oxygenators, Membrane / Q000592:standards*; D011126:Polypropylenes / Q000008:administration & dosage; D011446:Prospective Studies; D000077149:Sevoflurane; D016896:Treatment Outcome
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D011126:Polypropylenes; D000077149:Sevoflurane
keywords: anesthesia; cardiopulmonary bypass; drugs; evaluation; gas transfer; membrane oxygenator; oxygen; sevoflurane