title: Monoclonality of composite large-cell neuroendocrine carcinoma and invasive intestinal-type mucinous adenocarcinoma of the cervix: a case study.
abstract: A rare case of mixed carcinoma of the cervix is reported, composed of a large-cell neuroendocrine carcinoma and an invasive intestinal-type mucinous adenocarcinoma. The large-cell neuroendocrine carcinoma was composed of solid nests, sheets, and trabeculae of medium-sized to large-sized cells, and was positive for chromogranin-A and CD56. The invasive intestinal-type mucinous adenocarcinoma showed sparsely scattered immunoreactivity for chromogranin-A. Using an X-chromosome clonality assay, these 2 components showed patterns of monoclonality. These results suggest that the large-cell neuroendocrine carcinoma may have arisen from the invasive mucinous adenocarcinoma.
authors.affiliation: Departments of Clinical Laboratory Medicine, Wakayama Medical University, Kimiidera, Wakayama City, Wakayama, Japan. hyasuoka@mail.wakayama-med.ac.jp
authors.forename: Hironao
authors.initials: H
authors.lastname: Yasuoka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsujimoto
authors.forename: Machiko
authors.initials: M
authors.lastname: Ueda
authors.forename: Rieko
authors.initials: R
authors.lastname: Kodama
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Iwahashi
authors.forename: Michiya
authors.initials: M
authors.lastname: Inagaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Mabuchi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ino
authors.forename: Tokio
authors.initials: T
authors.lastname: Sanke
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology* / Q000601:surgery; D000328:Adult; D019002:CD56 Antigen / Q000378:metabolism*; D018287:Carcinoma, Large Cell / Q000473:pathology* / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000601:surgery; D002584:Cervix Uteri / Q000473:pathology; D053379:Chromogranin A / Q000378:metabolism*; D002999:Clone Cells; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D011944:Receptors, Androgen / Q000235:genetics
chemical_list: C410798:AR protein, human; D019002:CD56 Antigen; D053379:Chromogranin A; D004273:DNA, Neoplasm; C522918:NCAM1 protein, human; D011944:Receptors, Androgen