title: Diabetes and altered glucose metabolism with aging.
abstract: Diabetes and impaired glucose tolerance affect a substantial proportion of older adults. Abnormal glucose metabolism is not a necessary component of aging. Older adults with diabetes and altered glucose status likely represent a subset of the population at high risk for complications and adverse geriatric syndromes. Goals for treatment of diabetes in the elderly include control of hyperglycemia, prevention and treatment of diabetic complications, avoidance of hypoglycemia, and preservation of quality of life. Research exploring associations of dysglycemia and insulin resistance with the development of adverse outcomes in the elderly may ultimately inform use of future glucose-lowering therapies in this population.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, The Johns Hopkins University, Baltimore, MD 21287, USA. rrastogi@jhmi.edu
authors.forename: Rita Rastogi
authors.initials: RR
authors.lastname: Kalyani
authors.forename: Josephine M
authors.initials: JM
authors.lastname: Egan
mesh_terms: D000375:Aging; D000818:Animals; D048909:Diabetes Complications / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology* / Q000378:metabolism / Q000628:therapy; D044882:Glucose Metabolism Disorders / Q000097:blood / Q000453:epidemiology* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D057285:Precision Medicine
chemical_list: D007328:Insulin