title: [Influence of transition metal compounds on superoxide dismutase activity of sulfur reducing Desulfuromonas acetoxidans bacteria].
abstract: Superoxide dismutase, as one of the enzymes of cells' antioxidant defensive system, catalyzes superoxide anion-radical (O2-) dismutation with O2 and H2O2 forming. The influence of such transition metal compounds, as FeSO4, FeCl3, MnCl2, NiCl2, and CoCl2 on superoxide dismutase activity of sulfur-reducing Desulfuromonas acetoxidans bacteria has been investigated. Maximal activity of the investigated enzyme has been observed accordingly under the influence of 1.0 mM of NiCl2, 2.0 mM of CoCl2 and MnCl2 on the second day and under the influence of 1.0 mM of FeCl3 and FeSO4 respectively, on the third day of growth in comparison with control samples. An increase of incubation time and concentration of metal compound in the medium caused the inhibition of superoxide dismutase activity.
authors.forename: O M
authors.initials: OM
authors.lastname: Vasyliv
authors.forename: S O
authors.initials: SO
authors.lastname: Hnatush
mesh_terms: D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002712:Chlorides / Q000494:pharmacology; D003035:Cobalt / Q000494:pharmacology; D003470:Culture Media; D045287:Desulfuromonas / Q000187:drug effects* / Q000201:enzymology* / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D057075:Enzyme Assays; D005290:Ferric Compounds / Q000494:pharmacology; D005296:Ferrous Compounds / Q000494:pharmacology; D007700:Kinetics; D017895:Manganese Compounds / Q000494:pharmacology; D009532:Nickel / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D028561:Transition Elements / Q000494:pharmacology*
chemical_list: D001426:Bacterial Proteins; D002712:Chlorides; D003470:Culture Media; D005290:Ferric Compounds; D005296:Ferrous Compounds; D017895:Manganese Compounds; D028561:Transition Elements; C020748:ferrous sulfate; D003035:Cobalt; C022838:nickel chloride; D009532:Nickel; D013482:Superoxide Dismutase; C018021:cobaltous chloride; C025340:manganese chloride; C024555:ferric chloride