title: MLL-SEPT5 fusion transcript in infant acute myeloid leukemia with t(11;22)(q23;q11).
abstract: Chromosomal rearrangements involving the MLL gene at band 11q23 are the most common genetic alteration encountered in infant acute myeloid leukemia. Reciprocal translocation represents the most frequent form of MLL rearrangement. Currently, more than 60 partner genes have been identified. We report here a case of de novo acute myeloid leukemia with a t(11;22)(q23;q11) in a 23-month-old child. Fluorescence in situ hybridization study revealed that the 3'MLL segment was translocated onto the derivative chromosome 22 and the breakpoint on chromosome 22 was located in or near the SEPT5 gene at 22q11.21. Long distance inverse-polymerase chain reaction was used to identify precisely the MLL partner gene and confirmed the MLL-SEPT5 fusion transcript. Involvement of the SEPT5 gene in MLL rearrangement occurs very rarely. Clinical, cytogenetic and molecular features of acute myeloid leukemia with a MLL-SEPT5 fusion gene are reviewed.
authors.affiliation: Service de Cytogénétique et de Biologie Cellulaire.
authors.forename: Erika
authors.initials: E
authors.lastname: Launay
authors.forename: Catherine
authors.initials: C
authors.lastname: Henry
authors.forename: Claus
authors.initials: C
authors.lastname: Meyer
authors.forename: Céline
authors.initials: C
authors.lastname: Chappé
authors.forename: Sophie
authors.initials: S
authors.lastname: Taque
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Boulland
authors.forename: Raouf
authors.initials: R
authors.lastname: Ben Abdelali
authors.forename: Frédéric
authors.initials: F
authors.lastname: Dugay
authors.forename: Rolf
authors.initials: R
authors.lastname: Marschalek
authors.forename: Christian
authors.initials: C
authors.lastname: Bastard
authors.forename: Thierry
authors.initials: T
authors.lastname: Fest
authors.forename: Virginie
authors.initials: V
authors.lastname: Gandemer
authors.forename: Marc-Antoine
authors.initials: MA
authors.lastname: Belaud-Rotureau
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001483:Base Sequence; D002871:Chromosome Banding; D056905:Chromosome Breakpoints; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008969:Molecular Sequence Data; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D012074:Remission Induction; D014158:Transcription, Genetic; D014178:Translocation, Genetic
chemical_list: C000592550:MLL-SEPT5 fusion protein, human; D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein