title: Mutation analysis of papillary tubal hyperplasia associated with ovarian atypical proliferative serous tumor and low-grade serous carcinoma.
abstract: We present a patient with ovarian atypical proliferative serous tumor and low-grade serous carcinoma, related to KRAS mutation. Bilateral fallopian tubes had papillary tubal hyperplasia, providing additional evidence that it is the putative precursor of low-grade serous tumors. Mutation analysis of papillary tubal hyperplasia has not been done in previous literature.
authors.affiliation: Department of Anatomic Pathology, Far Eastern Memorial Hospital, Taipei, Taiwan.
authors.forename: Wen-Chih
authors.initials: WC
authors.lastname: Huang
authors.forename: Chien-Chen
authors.initials: CC
authors.lastname: Tsai
authors.forename: Ming-Chow
authors.initials: MC
authors.lastname: Wei
authors.forename: Kuan-Ting
authors.initials: KT
authors.lastname: Kuo
mesh_terms: D018284:Cystadenocarcinoma, Serous / Q000235:genetics*; D004252:DNA Mutational Analysis; D005185:Fallopian Tube Neoplasms / Q000235:genetics* / Q000473:pathology; D005187:Fallopian Tubes / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008875:Middle Aged; D009154:Mutation; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000235:genetics*; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins / Q000235:genetics*
chemical_list: C117307:KRAS protein, human; D011518:Proto-Oncogene Proteins; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins
keywords: KRAS mutation; low-grade serous carcinoma; ovary atypical proliferative serous tumor; papillary tubal hyperplasia; serous borderline tumor