title: Customized growth curves for identification of large-for-gestational age neonates in pre-eclamptic women.
abstract: OBJECTIVE
  To compare the role of two nomograms to classify large-for-gestational age (LGA) neonates in women with pre-eclampsia and to determine the frequency of placental vascular lesions according to the timing of delivery.
  
  
  METHODS
  This cohort study included 118 consecutive women with pre-eclampsia delivering between 23 and 41 weeks’ gestation. The frequencies of LGA neonates according to customized growth curves and a national birth weight (BW) chart were compared. Similarly, the frequencies of LGA neonates and histological placental vascular lesions were compared between pre-eclamptic women delivering at <34 weeks (n=40) and those delivering later (n=78).
  
  
  RESULTS
  Customized growth curves allowed classification of a higher proportion of LGA neonates than did BW curves (18.6% (22/118) vs 10.2% (12/118); P=0.002). Among pre-eclamptic women delivering at ≥34 weeks, but not earlier, the proportion of neonates classified as LGA by customized growth curves was higher than that classified by BW curves (26.9% (21/78) vs 15.4% (12/78); P=0.004). Placental vascular lesions were less frequent in pre-eclamptic women delivering at ≥34 weeks than in those delivering earlier (41% (32/78) vs 62.5% (25/40); P=0.03).
  
  
  CONCLUSIONS
  Customized growth curves allow classification of a higher proportion of LGA neonates than do population birth weight curves among women with pre-eclampsia delivering at ≥34 weeks. Pre-eclamptic women delivering at ≥34 weeks have fewer placental vascular lesions than do those delivering earlier.
authors.forename: J
authors.initials: J
authors.lastname: Espinoza
authors.forename: W
authors.initials: W
authors.lastname: Lee
authors.forename: S R
authors.initials: SR
authors.lastname: Martin
authors.forename: M A
authors.initials: MA
authors.lastname: Belfort
mesh_terms: D001724:Birth Weight; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000453:epidemiology*