title: Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory.
abstract: Although the requirement for new protein synthesis in synaptic plasticity and memory has been well established, recent genetic, molecular, electrophysiological, and pharmacological studies have broadened our understanding of the translational control mechanisms that are involved in these processes. One of the critical translational control points mediating general and gene-specific translation depends on the phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α) by four regulatory kinases. Here, we review the literature highlighting the important role for proper translational control via regulation of eIF2α phosphorylation by its kinases in long-lasting synaptic plasticity and long-term memory.
authors.affiliation: Pharmaceutical Research Division, CNS Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan.
authors.forename: Mimi A
authors.initials: MA
authors.lastname: Trinh
authors.forename: Eric
authors.initials: E
authors.lastname: Klann
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D015852:Eukaryotic Initiation Factor-2 / Q000378:metabolism; D006801:Humans; D057567:Memory, Long-Term / Q000502:physiology*; D051379:Mice; D009473:Neuronal Plasticity / Q000235:genetics*; D010766:Phosphorylation; D014176:Protein Biosynthesis; D019892:eIF-2 Kinase / Q000378:metabolism*
chemical_list: D015852:Eukaryotic Initiation Factor-2; D019892:eIF-2 Kinase
keywords: GCN2; HRI; Knockout eIF2; PERK; PKR; Synaptic plasticity; Translation initiation; long-term memory