title: Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor.
abstract: Hsp90, a key target in cancer therapy, has been identified as the main partner of oleocanthal, an olive oil bioactive compound. A combination of chemical and biological assays disclosed its mechanism of action at the molecular level.
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Margarucci
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Monti
authors.forename: Chiara
authors.initials: C
authors.lastname: Cassiano
authors.forename: Matteo
authors.initials: M
authors.lastname: Mozzicafreddo
authors.forename: Mauro
authors.initials: M
authors.lastname: Angeletti
authors.forename: Raffaele
authors.initials: R
authors.lastname: Riccio
authors.forename: Alessandra
authors.initials: A
authors.lastname: Tosco
authors.forename: Agostino
authors.initials: A
authors.lastname: Casapullo
mesh_terms: D000447:Aldehydes / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D045744:Cell Line, Tumor; D000081004:Cyclopentane Monoterpenes; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D062105:Molecular Docking Simulation; D000069463:Olive Oil; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism; D010938:Plant Oils / Q000737:chemistry; D011485:Protein Binding; D040901:Proteomics
chemical_list: D000447:Aldehydes; D000081004:Cyclopentane Monoterpenes; D018841:HSP90 Heat-Shock Proteins; D000069463:Olive Oil; D010636:Phenols; D010938:Plant Oils; C503534:oleocanthal