title: Evaluation of contralateral kidney, liver and lung after extracorporeal shock wave lithotripsy in rabbits.
abstract: An experimental study was carried out to evaluate the effects of extracorporeal shock wave lithotripsy (ESWL) on contralateral kidney, liver and lung by histopathological and biochemical methods. Twelve New Zealand rabbits were allocated to two groups (n = 6). Tissues of control group (CG, n = 6) were harvested without any intervention. In ESWL group (EG), right kidneys were exposed to 3,000 shock waves at 14 kV energy using electro-hydraulic type ESWL device three times every other day. Both kidneys, liver, and right lobe of lung tissues in EG were harvested on seventh day. Kidneys were examined histopathologically for presence of glomerular and tubular injury, interstitial edema, congestion, inflammation and fibrosis. Livers were examined for hepatocyte vacuolization, congestion, portal inflammation and fibrosis. Lung tissues were examined for loss of normal structure, emphysema, interstitial congestion-edema, prominent alveolar septal vessels, interstitial inflammation, intra-alveolar hemorrhage, intraluminal hemorrhage, peribronchial edema, congestion, inflammation in bronchial wall and epithelial desquamation. Biochemical analysis of tissue samples was performed for oxidative injury markers. Histopathological evaluations revealed that tubular injury was found in both shocked and contralateral kidneys (p < 0.05). EG showed higher grades of portal fibrosis in liver and higher grades of peribronchial congestion in lung when compared to CG (p < 0.05). Biochemical evaluations of both kidneys showed that malondialdehyde levels were higher in EG than in CG (p < 0.05). ESWL causes histopathologic alterations both in shocked and contralateral kidneys. Extrarenal tissues such as liver and lung can be affected by shock waves histopathologically and oxidative injury of contralateral kidney may occur acutely after ESWL.
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: M F
authors.initials: MF
authors.lastname: Senyucel
authors.forename: O
authors.initials: O
authors.lastname: Boybeyi
authors.forename: S
authors.initials: S
authors.lastname: Ayva
authors.forename: M K
authors.initials: MK
authors.lastname: Aslan
authors.forename: T
authors.initials: T
authors.lastname: Soyer
authors.forename: A I
authors.initials: AI
authors.lastname: Demet
authors.forename: U
authors.initials: U
authors.lastname: Kısa
authors.forename: M
authors.initials: M
authors.lastname: Basar
authors.forename: M A
authors.initials: MA
authors.lastname: Cakmak
mesh_terms: D000818:Animals; D007668:Kidney / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D008096:Lithotripsy / Q000009:adverse effects*; D008099:Liver / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D055370:Lung Injury / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008315:Malondialdehyde / Q000378:metabolism; D023421:Models, Animal; D018384:Oxidative Stress; D011817:Rabbits
chemical_list: D008315:Malondialdehyde