title: Recent developments in microfluidics-based chemotaxis studies.
abstract: Microfluidic devices can better control cellular microenvironments compared to conventional cell migration assays. Over the past few years, microfluidics-based chemotaxis studies showed a rapid growth. New strategies were developed to explore cell migration in manipulated chemical gradients. In addition to expanding the use of microfluidic devices for a broader range of cell types, microfluidic devices were used to study cell migration and chemotaxis in complex environments. Furthermore, high-throughput microfluidic chemotaxis devices and integrated microfluidic chemotaxis systems were developed for medical and commercial applications. In this article, we review recent developments in microfluidics-based chemotaxis studies and discuss the new trends in this field observed over the past few years.
authors.affiliation: Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
authors.forename: Jiandong
authors.initials: J
authors.lastname: Wu
authors.forename: Xun
authors.initials: X
authors.lastname: Wu
authors.forename: Francis
authors.initials: F
authors.lastname: Lin
mesh_terms: D001419:Bacteria / Q000166:cytology; D002465:Cell Movement; D002633:Chemotaxis; D018920:Coculture Techniques; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D044085:Microfluidics / Q000295:instrumentation / Q000379:methods*; D014411:Neoplastic Stem Cells / Q000166:cytology; D013234:Stem Cells / Q000166:cytology