title: [Spontaneous remission of acute myeloid leukemia - a single center case reports].
abstract: BACKGROUND
  Acute myeloid leukemia is a malignant disease characterized by clonal expansion of immature hematopoietic cells - myeloblasts - in the bone marrow. Intensive chemotherapy treatment in elderly patients (over 60) has disappointing results. In these patients, conservative treatment, including compensation of deficiency of red blood cells and platelets by transfusions and treatment of infectious complications is recommended. Also, relatively new treatment with hypometyl agents (azacytidine, decitabine) could be used.
  
  
  METHODS
  The idea of this article is to present a spontaneous remission phenomenon, which has not been published in Czech literature yet. In this article, we present 2 case studies of our patients who were diagnosed with acute myeloid leukemia, were not treated with chemotherapy and spontaneously reached remission of acute myeloid leukemia.
  
  
  CONCLUSIONS
  The mechanisms of the spontaneous remission remain unclear, but we assume positive effect of a severe systemic infection or previous applications of blood transfusions. Antibodies in blood transfusions and a strong immune response to sepsis may have contributed to spontaneous remission.
authors.affiliation: Hematologicko-onkologicke oddeleni, FN Plzen. pachnerm@fnplzen.cz
authors.forename: M
authors.initials: M
authors.lastname: Pachner
authors.forename: S
authors.initials: S
authors.lastname: Vokurka
authors.forename: V
authors.initials: V
authors.lastname: Koza
authors.forename: T
authors.initials: T
authors.lastname: Svoboda
authors.forename: M
authors.initials: M
authors.lastname: Hrabětová
authors.forename: P
authors.initials: P
authors.lastname: Jindra
authors.forename: D
authors.initials: D
authors.lastname: Lysák
authors.forename: V
authors.initials: V
authors.lastname: Vozobulová
authors.forename: M
authors.initials: M
authors.lastname: Schutzova
authors.forename: M
authors.initials: M
authors.lastname: Karas
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D008875:Middle Aged; D012075:Remission, Spontaneous