title: Effect of intranasal budesonide irrigations on intraocular pressure.
abstract: BACKGROUND
  Intranasal and oral corticosteroids are widely used in the management of chronic rhinosinusitis with nasal polyps (CRSwNP). Higher-dose topical nasal steroids (HDTNS) such as budesonide irrigations are increasingly used for long-term maintenance in these patients. Oral steroids have the potential to cause increased intraocular pressure (IOP) and glaucoma. It is unclear whether HDTNS have the same potential. The objective of this study was to determine the effect of intranasal budesonide irrigations on IOP.
  
  
  METHODS
  Two groups of patients with CRSwNP treated with budesonide irrigations were prospectively enrolled. Patients with history of elevated IOP or glaucoma were excluded. Patients in group 1 had been using budesonide for at least 1 month and had IOP measured once at the time of enrollment. Group 2 consisted of patients who were placed on budesonide at the time of enrollment and had IOP measured both before and after at least 4 weeks of therapy.
  
  
  RESULTS
  Ten patients in group 1 and 8 patients in group 2 completed the study. In group 1, the average duration of therapy at enrollment was 6.3 months (1-22 months). Only 1 patient had a single eye pressure above 21 mmHg. None of the patients in group 2 had a significant change in IOP or IOP over 21 mmHg.
  
  
  CONCLUSIONS
  Intranasal budesonide irrigations given for a period of at least 1 month do not appear to increase IOP.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Loma Linda University Medical Center, Loma Linda, CA.
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Seiberling
authors.forename: Dennis F
authors.initials: DF
authors.lastname: Chang
authors.forename: Janice
authors.initials: J
authors.lastname: Nyirady
authors.forename: Francine
authors.initials: F
authors.lastname: Park
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Church
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D019819:Budesonide / Q000008:administration & dosage / Q000009:adverse effects*; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D009798:Ocular Hypertension / Q000209:etiology*; D011446:Prospective Studies; D012220:Rhinitis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D012852:Sinusitis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D007507:Therapeutic Irrigation; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D019819:Budesonide
keywords: Pulmicort; budesonide irrigations; chronic rhinosinusitis; glaucoma; intranasal steroids; intraocular hypertension; nasal polyps