title: Effect of atorvastatin on expression of TLR4 and NF-κB p65 in atherosclerotic rabbits.
abstract: OBJECTIVE
  To study the effect of atorvastatin on atherosclerotic rabbits.
  
  
  METHODS
  A total of 60 New Zealand male rabbits were randomly divided into the normal group, model group and atorvastatin group. The replication rabbit atherosclerotic model with immune injury combined with a high fat diet feeding was used. All rabbits were sacrificed after 3 months. TLR4 and NF-κB p65 were observed by HE staining, immunohistochemistry and western blotting.
  
  
  RESULTS
  The expression of TLR4, NF-κB p65 were significantly increased in the model group compared with the normal group. The expression of TLR4 and NF-κB p65 decreased significantly in the atorvastatin group, and there was no difference compared with the normal group.
  
  
  CONCLUSIONS
  The effect of atorvastatin on atherosclerosis may be achieved by the inhibition of the expression of TLR4 and NF-κB p65.
authors.affiliation: Shanghai Geriatric Institute of Chinese Medicine, Longhua Hospital Affiliated Shanghai University of Traditional Chinese Medicine, Shanghai 200031, PR China.
authors.forename: Ding-Zhu
authors.initials: DZ
authors.lastname: Shen
authors.forename: San-Li
authors.initials: SL
authors.lastname: Xin
authors.forename: Chuan
authors.initials: C
authors.lastname: Chen
authors.forename: Te
authors.initials: T
authors.lastname: Liu
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D001011:Aorta / Q000378:metabolism; D050197:Atherosclerosis / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D000069059:Atorvastatin; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004195:Disease Models, Animal; D015870:Gene Expression; D006538:Heptanoic Acids / Q000494:pharmacology*; D006651:Histocytochemistry; D008297:Male; D011758:Pyrroles / Q000494:pharmacology*; D011817:Rabbits; D011897:Random Allocation; D051197:Toll-Like Receptor 4 / Q000096:biosynthesis*; D051996:Transcription Factor RelA / Q000096:biosynthesis*
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006538:Heptanoic Acids; D011758:Pyrroles; D051197:Toll-Like Receptor 4; D051996:Transcription Factor RelA; D000069059:Atorvastatin