title: Study on antitubercular constituents from the seeds of Nigella glandulifera.
abstract: Two new compounds with five known compounds have been isolated from EtOH extract of the seeds of Nigella glandulifera. On the basis of their spectroscopic and chemical evidence, the new compounds were elucidated as methoxynigeglanine (1) and 6-methoxythymol-3-O-β-D-glucopyranoside (4). Compounds 1-4 showed moderate antitubercular activity against Mycobacterium tuberculosis strain H37Rv with minimal inhibitory concentration (MIC) values of 32-250 µg/mL.
authors.affiliation: The Key Laboratory of Biomedical Engineering, Ministry of Education, China, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Lian-li
authors.initials: LL
authors.lastname: Sun
authors.forename: Ming
authors.initials: M
authors.lastname: Luan
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.forename: Shuai
authors.initials: S
authors.lastname: Gao
authors.forename: Qian-lan
authors.initials: QL
authors.lastname: Zhang
authors.forename: Chan-juan
authors.initials: CJ
authors.lastname: Xu
authors.forename: Xiang-hong
authors.initials: XH
authors.lastname: Lu
authors.forename: Xiang-dong
authors.initials: XD
authors.lastname: Xu
authors.forename: Jing-Kui
authors.initials: JK
authors.lastname: Tian
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D031844:Nigella / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D005960:Glucosides; D010936:Plant Extracts