title: (1) H-MR spectroscopy characterization of the adipose tissue associated with colorectal tumor.
abstract: OBJECTIVE
  To investigate colorectal tumor by looking at the lipid tissue around the lesion. Adipose tissue is not only an inert storage system for excess calories, but is involved in several pathological processes linked to tumor development.
  
  
  METHODS
  We obtained 24 colorectal specimens after surgical excision from patients affected by colorectal cancer at different tumor stages. (1) H-MR spectoscopy (MRS) spectra were collected from two voxels, in proximity of the lesion and far from it, in each specimen with a preclinical scanner. We differentiated patients by pathological tumor stage, and we compared the chemical composition of adipose tissue between patient groups, both close the tumor and far from it.
  
  
  RESULTS
  Monounsaturated fatty acids (MUFA) close the lesion are increased at higher tumor stages, while MUFA far from the lesion do not follow this trend. This study is really explorative due to the small numbers of subjects and we are cautious on the interpretation of the results. However, the approach of the present work allows a further insight in the tumor characterization.
  
  
  CONCLUSIONS
  Looking at the lipid tissue around a lesion through (1) H-MRS can return important information regarding its genesis and development.
authors.affiliation: Department of Computer Sciences, University of Verona, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Mosconi
authors.forename: Annamaria
authors.initials: A
authors.lastname: Minicozzi
authors.forename: Pasquina
authors.initials: P
authors.lastname: Marzola
authors.forename: Claudio
authors.initials: C
authors.lastname: Cordiano
authors.forename: Andrea
authors.initials: A
authors.lastname: Sbarbati
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology*; D050154:Adiposity; D000368:Aged; D000465:Algorithms; D015179:Colorectal Neoplasms / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D008055:Lipids; D011522:Protons
keywords: 1H-MRS; colorectal cancer; lipidomics; saturated fatty acids