title: Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions, and health are distinct. Possible implications for CRC screening and surveillance.
abstract: Alternate colorectal cancer (CRC) screening and surveillance strategies are needed to pre-select candidates for invasive methods. We compared systemic inflammatory profiles in CRC (n=99), health (n=98), high CRC-risk conditions (n=48) and overt inflammation (n=69) by multiplexed analysis of IL-1β, IL-6, IL-8, FGF-2, G-CSF, GM-CSF, MCP-1, MIP-1α, TNF-α, VEGF-A, and PDGF-B and CEA. Cytokines corresponded with CRC advancement. FGF2, GM-CSF, IL-1β, IL-6, MIP-1α, PDGF-BB, TNF-α, and VEGF-A were higher than in controls already in stage I CRC with FGF2, IL1-β, and MIP-1α higher than in high CRC-risk individuals as well. Cytokine panels devised to differentiate early CRC from controls, adenomas, or inflammatory bowel disease patients (IBD) had good accuracy but only IBD panel had promising specificity at 95% sensitivity.
authors.affiliation: Department of Medical Biochemistry, Wroclaw Medical University, Wroclaw, Poland. malgorzata.krzystek-korpacka@umed.wroc.pl
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Krzystek-Korpacka
authors.forename: Dorota
authors.initials: D
authors.lastname: Diakowska
authors.forename: Bartosz
authors.initials: B
authors.lastname: Kapturkiewicz
authors.forename: Marek
authors.initials: M
authors.lastname: Bębenek
authors.forename: Andrzej
authors.initials: A
authors.lastname: Gamian
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D016207:Cytokines / Q000097:blood*; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012306:Risk
chemical_list: D016207:Cytokines
keywords: Biomarker; Cancer screening; Colorectal cancer; Cytokines; Multiplex