title: miR-155 is involved in tumor progression of mycosis fungoides.
abstract: Biopsy specimens from 23 early stage and 19 tumor-stage mycosis fungoides (MF) patients were evaluated for miR-155 expression by real-time qualitative PCR and compared with 15 biopsy specimens from patients with T-cell-rich inflammatory skin diseases. Significant upregulation of miR-155 was found in MF tumors compared with both early-stage MF lesions and controls. There was no difference in miR-155 expression between early-stage and inflammatory dermatoses. Using laser capture microdissection, it was found that miR-155 was significantly higher in the lymphoma cells in tumor stage compared with the intraepidermal lymphocytes in early stage. In contrast, there was no difference in miR-155 expression between the intraepidermal lymphocytes and the dermal lymphocytes in early-stage MF. These findings suggest that although miR-155 expression cannot serve to discriminate early-stage MF from inflammatory dermatoses; however, it is involved in the switch from the indolent early stage into the aggressive tumor stage of the disease.
authors.forename: Lilach
authors.initials: L
authors.lastname: Moyal
authors.forename: Aviv
authors.initials: A
authors.lastname: Barzilai
authors.forename: Batia
authors.initials: B
authors.lastname: Gorovitz
authors.forename: Avi
authors.initials: A
authors.lastname: Hirshberg
authors.forename: Ninette
authors.initials: N
authors.lastname: Amariglio
authors.forename: Jasmine
authors.initials: J
authors.lastname: Jacob-Hirsch
authors.forename: Leah
authors.initials: L
authors.lastname: Maron
authors.forename: Meora
authors.initials: M
authors.lastname: Feinmesser
authors.forename: Emmilia
authors.initials: E
authors.lastname: Hodak
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D018450:Disease Progression; D005260:Female; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007249:Inflammation / Q000473:pathology; D061346:Laser Capture Microdissection; D008214:Lymphocytes / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction; D012867:Skin / Q000473:pathology; D012871:Skin Diseases; D012878:Skin Neoplasms / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism; D015854:Up-Regulation
chemical_list: C524942:MIRN155 microRNA, human; D035683:MicroRNAs