title: Response to comments on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".
abstract: The data reported in the Technical Comments by Fitz et al., Price et al., Tesseur et al., and Veeraraghavalu et al. replicate and validate our central conclusion that bexarotene stimulates the clearance of soluble β-amyloid peptides and results in the reversal of behavioral deficits in mouse models of Alzheimer's disease (AD). The basis of the inability to reproduce the drug-stimulated microglial-mediated reduction in plaque burden is unexplained. However, we concluded that plaque burden is functionally unrelated to improved cognition and memory elicited by bexarotene.
authors.affiliation: Alzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. gel2@case.edu
authors.forename: Gary E
authors.initials: GE
authors.lastname: Landreth
authors.forename: Paige E
authors.initials: PE
authors.lastname: Cramer
authors.forename: Mitchell M
authors.initials: MM
authors.lastname: Lakner
authors.forename: John R
authors.initials: JR
authors.lastname: Cirrito
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Wesson
authors.forename: Kurt R
authors.initials: KR
authors.lastname: Brunden
authors.forename: Donald A
authors.initials: DA
authors.lastname: Wilson
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D008297:Male; D013764:Tetrahydronaphthalenes / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D013764:Tetrahydronaphthalenes