title: Peyronie's disease: a "triple oxygenant therapy".
abstract: OBJECTIVE
  To evaluate the effects of upregulators of nitric oxide in one patient with Peyronie’s disease, after non significant improvement following intracavernosal verapamil.
  
  
  METHODS
  A 20-years-old Caucasian male presented with penile induration in flaccid state, persistent during erection and associated with mild pain at third middle of penis. After treatment with intracavernosal verapamil for 4 months with relief of penile discomfort, followed by counseling on the use of penile extender for at least 6 hours per day, he was prescribed pentoxifylline associated with tadalafil plus levo-arginine, propionil-carnitine and Vitamin B3.
  
  
  RESULTS
  After almost 2 years, the septal thickness was reduced at ultrasound evaluation after this &ldquo;triple oxygenant therapy&rdquo;.
  
  
  CONCLUSIONS
  NO-iNOS biology in Peyronie patients is the very protagonist in modulating penile fibrosis through up-regulation of NO-cGMP pathway that influences penile health by preventing and reversing fibrosis in the tunical albuginea.
authors.affiliation: U.O.C. Urologia 2 - Andrologia e Riproduzione Assistita, Azienda Ospedaliera San Paolo - Polo Universitario, Milano, Italy. ciociolafrancesco@libero.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Ciociola
authors.forename: Giovanni Maria
authors.initials: GM
authors.lastname: Colpi
mesh_terms: D001120:Arginine / Q000627:therapeutic use*; D002243:Carbolines / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010411:Penile Induration / Q000188:drug therapy*; D010431:Pentoxifylline / Q000627:therapeutic use*; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use*; D000068581:Tadalafil; D055815:Young Adult
chemical_list: D002243:Carbolines; D016166:Free Radical Scavengers; D058986:Phosphodiesterase 5 Inhibitors; D000068581:Tadalafil; D001120:Arginine; D010431:Pentoxifylline