title: Diagnostic sensitivity of SPECT myocardial perfusion imaging using a pumping cardiac phantom with inserted variable defects.
abstract: BACKGROUND
  The diagnostic sensitivity of various SPECT MPI procedures was assessed using a pumping cardiac phantom with variable defects inserted in the myocardial wall of the left ventricle.
  
  
  RESULTS
  A diagnostic evaluation of 142 myocardial defects was performed. A diagnosis blinded to prior-known conditions was compared to the known defects severity (transmural, subendocardial) and defects position within the myocardial wall of the left ventricle (apical, anterior, inferior) for three body types (average male, large male, large female). Non-attenuation corrected, attenuation corrected and gated SPECT MPI were performed. The diagnostic sensitivity was improved when applying attenuation correction or gating techniques to identify subendocardial defects in the inferior, anterior and apical segments of the myocardial wall of the left ventricle for all three body types. Transmural defects could be identified without any attenuation correction or gating.
  
  
  CONCLUSIONS
  The diagnostic sensitivity was improved when applying AC or GSPECT techniques.
authors.affiliation: Frederick Research Centre, Nicosia, Cyprus. isabelle.chrysanthou@gmail.com
authors.forename: Isabelle
authors.initials: I
authors.lastname: Chrysanthou-Baustert
authors.forename: Yiannis
authors.initials: Y
authors.lastname: Parpottas
authors.forename: Ourania
authors.initials: O
authors.lastname: Demetriadou
authors.forename: Stelios
authors.initials: S
authors.lastname: Christofides
authors.forename: Charalambos
authors.initials: C
authors.lastname: Yiannakkaras
authors.forename: Demetris
authors.initials: D
authors.lastname: Kaolis
authors.forename: Marta
authors.initials: M
authors.lastname: Wasilewska-Radwanska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Fiutowski
authors.forename: Franciszek
authors.initials: F
authors.lastname: Sikora
mesh_terms: D000328:Adult; D016477:Artifacts; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003971:Diastole; D004867:Equipment Design; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006352:Heart Ventricles / Q000002:abnormalities / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D009206:Myocardium / Q000473:pathology*; D019047:Phantoms, Imaging; D012680:Sensitivity and Specificity; D013599:Systole; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*