title: Drug-induced immune thrombocytopenia.
abstract: Thrombocytopenia is caused by immune reactions elicited by diverse drugs in clinical practice. The activity of the drug-dependent antibodies produces a marked decrease in blood platelets and a risk of serious bleeding. Understanding of the cellular mechanisms that drive drug-induced thrombocytopenia has advanced recently but there is still a need for improved laboratory tests and treatment options. This article provides an overview of the different types of drug-induced thrombocytopenia, discusses potential pathologic mechanisms, and considers diagnostic methods and treatment options.
authors.affiliation: Haematology Department, St George Hospital, Kogarah, NSW 2217, Australia. beng.chong@unsw.edu.au
authors.forename: Beng H
authors.initials: BH
authors.lastname: Chong
authors.forename: Philip Young-Ill
authors.initials: PY
authors.lastname: Choi
authors.forename: Levon
authors.initials: L
authors.lastname: Khachigian
authors.forename: Jose
authors.initials: J
authors.lastname: Perdomo
mesh_terms: D000077284:Abciximab; D000906:Antibodies / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000009:adverse effects; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology; D006241:Haptens / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000009:adverse effects; D015994:Incidence; D010980:Platelet Membrane Glycoproteins / Q000276:immunology; D011803:Quinine / Q000009:adverse effects / Q000276:immunology; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000145:classification / Q000175:diagnosis / Q000276:immunology*
chemical_list: D000906:Antibodies; D000911:Antibodies, Monoclonal; D006241:Haptens; D007140:Immunoglobulin Fab Fragments; D010980:Platelet Membrane Glycoproteins; D011803:Quinine; D000077284:Abciximab