title: Sonographic Findings of Medullary Thyroid Carcinoma Leading to Diagnosis of Multiple Endocrine Neoplasia Type 2a during Pregnancy.
abstract: Multiple endocrine neoplasia (MEN) type 2a (Sipple's syndrome) is characterized by medullary thyroid carcinoma and pheochromocytoma, and in a smaller percentage of cases, multiglandular parathyroid hyperplasia. This autosomal-dominant syndrome is due to a mutation in the rearranged during transfection (RET) proto-oncogene located on chromosome 10cen-10q11.2 and rarely complicates pregnancy. We present an unusual case in a patient with an enlarged thyroid with sonographic findings characteristic of thyroid cancer, which led to diagnosis and subsequent management of RET proto-oncogene-positive MEN type 2a complicating pregnancy.
authors.affiliation: Divisions of Maternal-Fetal Medicine and Gynecologic Oncology, Departments of Obstetrics and Gynecology and Radiology, State University of New York, Downstate Medical Center, Brooklyn, New York.
authors.forename: David M
authors.initials: DM
authors.lastname: Sherer
authors.forename: Mudar
authors.initials: M
authors.lastname: Dalloul
authors.forename: Ghadir
authors.initials: G
authors.lastname: Salame
authors.forename: Tana
authors.initials: T
authors.lastname: Shah
authors.forename: Eli
authors.initials: E
authors.lastname: Serur
authors.forename: Harry L
authors.initials: HL
authors.lastname: Zinn
authors.forename: Ovadia
authors.initials: O
authors.lastname: Abulafia
keywords: Pregnancy; multiple endocrine neoplasia type 2a; pheochromocytoma; thyroid carcinoma; ultrasound