title: Virome genomics: a tool for defining the human virome.
abstract: High throughput, deep sequencing assays are powerful tools for gaining insights into virus-host interactions. Sequencing assays can discover novel viruses and describe the genomes of novel and known viruses. Genomic information can predict viral proteins that can be characterized, describe important genes in the host that control infections, and evaluate gene expression of viruses and hosts during infection. Sequencing can also describe variation and evolution of viruses during replication and transmission. This review recounts some of the major advances in the studies of virus-host interactions from the last two years, and discusses the uses of sequencing technologies relating to these studies.
authors.affiliation: The Genome Institute, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St. Louis, MO 63108, United States. kwylie@genome.wustl.edu
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Wylie
authors.forename: George M
authors.initials: GM
authors.lastname: Weinstock
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Storch
mesh_terms: D023281:Genomics / Q000379:methods*; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D006801:Humans; D064307:Microbiota; D014773:Virology / Q000379:methods*; D014780:Viruses / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*