title: Definitive treatment of androgen receptor-positive salivary duct carcinoma with androgen deprivation therapy and external beam radiotherapy.
abstract: BACKGROUND
  Salivary duct carcinoma (SDC) is an aggressive malignancy with high recurrence rates. Standard management includes surgical resection followed by adjuvant radiation. Androgen receptor positivity has been described to be present in 40% to 90% of SDCs, and a recent case series showed a benefit to androgen deprivation therapy (ADT) in recurrent or metastatic disease.
  
  
  RESULTS
  We present the case of an 87-year-old woman with a locally advanced androgen receptor-positive parotid SDC treated definitively with ADT and external beam radiotherapy, a regimen modeled after the treatment of prostate cancer. She had a complete response on positron emission tomography (PET)/CT scan and had no evidence of disease 24 months after the completion of treatment.
  
  
  CONCLUSIONS
  To our knowledge, this case report is the first to describe the use of ADT plus radiation to definitively treat SDC. This regimen could be considered in patients with androgen receptor-positive SDCs who are considered unresectable or who refuse surgery.
authors.affiliation: Department of Radiation Oncology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Soper
authors.forename: Shawn
authors.initials: S
authors.lastname: Iganej
authors.forename: Lester D R
authors.initials: LD
authors.lastname: Thompson
mesh_terms: D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000813:Anilides / Q000627:therapeutic use; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D016729:Leuprolide / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging / Q000379:methods; D009367:Neoplasm Staging; D009570:Nitriles / Q000627:therapeutic use; D049268:Positron-Emission Tomography; D050397:Radiotherapy, Intensity-Modulated; D011944:Receptors, Androgen / Q000378:metabolism; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*; D014105:Tosyl Compounds / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists; D000813:Anilides; D009570:Nitriles; D011944:Receptors, Androgen; D014105:Tosyl Compounds; C053541:bicalutamide; D016729:Leuprolide
keywords: androgen deprivation therapy; androgen receptor; radiation; salivary duct carcinoma; salivary gland