title: Neuroblastoma: developmental biology, cancer genomics and immunotherapy.
abstract: Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous system. Over the past decade, our understanding of this disease has advanced tremendously. The future challenge is to apply the knowledge gained to developing risk-based therapies and, ultimately, improving outcome. In this Review we discuss the key discoveries in the developmental biology, molecular genetics and immunology of neuroblastoma, as well as new translational tools for bringing these promising scientific advances into the clinic.
authors.affiliation: Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. cheungn@mskcc.org
authors.forename: Nai-Kong V
authors.initials: NK
authors.lastname: Cheung
authors.forename: Michael A
authors.initials: MA
authors.lastname: Dyer
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D000818:Animals; D019496:Cancer Vaccines; D004265:DNA Helicases / Q000235:genetics; D023281:Genomics; D006801:Humans; D007167:Immunotherapy; D009154:Mutation; D009432:Neural Crest / Q000473:pathology; D009447:Neuroblastoma / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D009687:Nuclear Proteins / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D013564:Sympathetic Nervous System / Q000254:growth & development / Q000473:pathology*; D000075924:X-linked Nuclear Protein
chemical_list: D019496:Cancer Vaccines; D009687:Nuclear Proteins; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases; D004265:DNA Helicases; C092332:ATRX protein, human; D000075924:X-linked Nuclear Protein