title: PDGF-C: a new performer in the neurovascular interplay.
abstract: The importance of neurovascular crosstalk in development, normal physiology, and pathologies is increasingly being recognized. Although vascular endothelial growth factor (VEGF), a prototypic regulator of neurovascular interaction, has been studied intensively, defining other important regulators in this process is warranted. Recent studies have shown that platelet-derived growth factor C (PDGF-C) is both angiogenic and a neuronal survival factor, and it appears to be an important component of neurovascular crosstalk. Importantly, the expression pattern and functional properties of PDGF-C and its receptors differ from those of VEGF, and thus the PDGF-C-mediated neurovascular interaction may represent a new paradigm of neurovascular crosstalk.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, P.R. China.
authors.forename: Chunsik
authors.initials: C
authors.lastname: Lee
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Zhongshu
authors.initials: Z
authors.lastname: Tang
authors.forename: Yizhi
authors.initials: Y
authors.lastname: Liu
authors.forename: Xuri
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000378:metabolism*; D006801:Humans; D008222:Lymphokines / Q000378:metabolism*; D009420:Nervous System / Q000378:metabolism*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D020239:Receptor Cross-Talk; D017479:Receptors, Platelet-Derived Growth Factor / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D008222:Lymphokines; D010982:Platelet-Derived Growth Factor; C411423:platelet-derived growth factor C; D017479:Receptors, Platelet-Derived Growth Factor
keywords: PDGF-C; angiogenesis; neuroprotection; neurovascular crosstalk; survival