title: Normalisation of angiogenic imbalance after intra-uterine transfusion for mirror syndrome caused by parvovirus B19.
abstract: We report a case of mirror syndrome caused by parvovirus B19, which resolved after intra-uterine transfusion. Mirror syndrome is a rare condition characterised by a triad of foetal hydrops, generalized maternal oedema and placentomegaly. Although the mechanism underlying the onset of this syndrome is unknown, it probably shares a common pathophysiologic origin with pre-eclampsia. Our patient showed increased circulating levels of soluble fms-like tyrosine kinase 1 (sFlt-1) and decreased levels of placental growth factor (PlGF), which have also been reported in pre-eclampsia. The sFlt-1/PlGF ratio decreased immediately after intra-uterine transfusion, followed by resolution of both maternal and foetal symptoms. This suggests that the sFlt-1/PlGF ratio may help to predict the post-treatment course of mirror syndrome.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Goa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Mimura
authors.forename: Aiko
authors.initials: A
authors.lastname: Kakigano
authors.forename: Takuji
authors.initials: T
authors.lastname: Tomimatsu
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kinugasa-Taniguchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Endo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kanagawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kimura
mesh_terms: D000328:Adult; D001805:Blood Transfusion, Intrauterine; D006063:Chorionic Gonadotropin / Q000097:blood; D004487:Edema / Q000150:complications; D016731:Erythema Infectiosum / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000175:diagnosis* / Q000628:therapy; D000072483:Placenta Growth Factor; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood; D013577:Syndrome; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood
chemical_list: D006063:Chorionic Gonadotropin; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1