title: [Immune reactions following excimer laser and femtosecond laser-assisted penetrating keratoplasty].
abstract: In 10-20 % of conventional keratoplasties immunological graft reactions (TPR) occur, which may lead to endothelial cell loss and irreversible transplant rejection. Beside the optical advantages of non-mechanical excimer laser trephination, it does not seem to have immunological disadvantages (13.9 % TPR in keratoconus, 2.9 % in Fuchs' dystrophy after 3 years). The femtosecond laser-assisted keratoplasty has visual and refractive outcomes similar to conventional trephination. However, the "mushroom-shaped" trephination seems to have immunological disadvantages (21.8 % TPR in keratoconus after 14 months) and "top hat-shaped" keratoplasties seem to have no immunological disadvantages (6.6 % TPR in Fuchs' dystrophy after 14 months).
authors.affiliation: Klinik für Augenheilkunde, Universitätsklinikum des Saarlandes, Kirrberger Strasse 1, Homburg. nszentmary@hotmail.com
authors.forename: N
authors.initials: N
authors.lastname: Szentmáry
authors.forename: S
authors.initials: S
authors.lastname: Goebels
authors.forename: M
authors.initials: M
authors.lastname: El-Husseiny
authors.forename: A
authors.initials: A
authors.lastname: Langenbucher
authors.forename: B
authors.initials: B
authors.lastname: Seitz
mesh_terms: D004728:Endothelium, Corneal / Q000276:immunology*; D006084:Graft Rejection / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007154:Immune System Diseases / Q000209:etiology / Q000276:immunology*; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D053685:Laser Therapy / Q000009:adverse effects*