title: Genetic variants in TERT-CLPTM1L genetic region associated with several types of cancer: a meta-analysis.
abstract: BACKGROUND
  TERT-CLPTM1L genomic region has been extensively associated with several types of cancer. However, results were inconsistent. We performed this meta-analysis to estimate the association between TERT (rs2736100, rs2736098), as well as CLPTM1L (rs402710, rs401681) polymorphisms and cancer risk.
  
  
  METHODS
  Electronic search in PubMed, EMBASE and China National Knowledge Infrastructure (CNKI) was conducted to select the studies. Studies containing available genotype frequencies of those 4 polymorphisms were chosen, and overall odds ratio (OR) with 95% confidence interval (CI) was used to assess the association.
  
  
  RESULTS
  The final meta-analysis included 16 published case-control studies. Increased cancer risk was found between TERT-rs2736100, as well as CLPTM1L-rs402710 and cancer susceptibility. In addition, we found an increased risk of cancer in both rs2736098 and rs401681 homozygous variant genetic model.
  
  
  CONCLUSIONS
  This meta-analysis suggested that TERT-CLPTM1L genomic region was associated with increased risk of cancer. To validate the association between these polymorphisms and cancer susceptibility, further studies with larger participants are needed.
authors.affiliation: Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110001, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Yin
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Xuelian
authors.initials: X
authors.lastname: Li
authors.forename: Baosen
authors.initials: B
authors.lastname: Zhou
mesh_terms: D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D056426:Genetic Loci; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D017594:Publication Bias; D019098:Telomerase / Q000235:genetics*
chemical_list: C422445:CLPTM1L protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; C509186:TERT protein, human; D019098:Telomerase
keywords: CI; CLPTM1L; CNKI; Cancer susceptibility; China National Knowledge Infrastructure; Cleft lip and palate transmembrane 1-like; Confidence interval; GWAS; Genome-wide association studies; HWE; Hardy–Weinberg equilibrium; LD; Linkage disequilibrium; Meta-analysis; NOS; Newcastle–Ottawa assessment scale; OR; Odds ratio; PCR-RFLP; Polymerase chain reaction –restriction fragment length polymorphism; Polymorphism; TERT; Telomerase reverse transcriptase