title: [Anticancer activity of Crocodylus siamensis blood in vitro and in vivo].
abstract: OBJECTIVE
  To study the anticancer effects of the blood of Crocodylus siamensis in vitro and in vivo.
  
  
  METHODS
  The inhibitory effects of serum and plasma of Crocodylus siamensis on proliferation of HepG2, BGC823, HeLa and SKOV3 cell were measured by MTT assay. The mouse S180 tumor model was used to evaluate the anti-tumor effect in vivo.
  
  
  RESULTS
  High dosage serum and plasma of Crocodylus siamensis could inhibit the proliferation of HepG2, BGC823, HeLa and SKOV3 cell. The tumor inhibitory rate of high dosage blood of Crocodylus siamensis on S180 tumor was up to 57.55%.
  
  
  CONCLUSIONS
  The blood of breeding Crocodylus siamensis has anticancer activity.
authors.affiliation: Department of Biological Pharmaceutics, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. piece124@hotmail.com
authors.forename: Di
authors.initials: D
authors.lastname: Geng
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Duan
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Xu
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Wang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Cui
authors.forename: Zhao
authors.initials: Z
authors.lastname: Ouyang
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
mesh_terms: D000284:Administration, Oral; D000489:Alligators and Crocodiles; D000818:Animals; D000970:Antineoplastic Agents / Q000276:immunology / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival; D005260:Female; D006801:Humans; D008297:Male; D008419:Materia Medica / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D009368:Neoplasm Transplantation; D010949:Plasma; D012510:Sarcoma 180 / Q000378:metabolism / Q000473:pathology*; D044967:Serum; D013950:Thymus Gland / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D008419:Materia Medica