title: Association of red blood cell distribution width, inflammation markers and morphological as well as rheological erythrocyte parameters with target organ damage in hypertension.
abstract: OBJECTIVE
  To assess the relationships of red blood cell distribution width (RDW), mean corpuscular hemoglobin concentration (MCHC) and erythrocyte deformability with pathological changes of selected target organs, and with inflammation markers interleukin-6 (IL-6) and fibrinogen, in a group of newly diagnosed, never-treated and otherwise healthy hypertensive patients.
  
  
  METHODS
  The study group consisted of 101 adults divided into three sub-groups: 37 diagnosed arterial hypertension, 29 with hypercholesterolemia, and 35 healthy. The individuals with hypertension or hypercholesterolemia were otherwise healthy and were not on any therapy prior to entering the study. For each individual, data were obtained on: systolic and diastolic blood pressure (SBP, DBP), pulse wave velocity (PWV), carotid intima media thickness (IMT), left ventricle geometry, blood morphology, lipids profile, fibrinogen, CRP, IL-6 and red blood cell deformability index (DI).
  
  
  RESULTS
  In the group of hypertensives, the multivariate regression analysis showed significant relationship of RDW with PWV, IL6 and fibrinogen. Also, RDW was found to be correlated with MCHC and DI, and MCHC was significantly related to IMT and IL-6.
  
  
  CONCLUSIONS
  A hypothesis has been formulated that the development of target organ damage in hypertension is accompanied by the increasing impairment of erythropoiesis. This process may be mediated by inflammation.
authors.affiliation: Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Fornal
authors.affiliation: Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Wizner
authors.affiliation: Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Cwynar
authors.affiliation: Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Królczyk
authors.affiliation: Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Kwater
authors.affiliation: Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Renata A
authors.initials: RA
authors.lastname: Korbut
authors.affiliation: Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Grodzicki
mesh_terms: D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000473:pathology*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000473:pathology; D006973:Hypertension / Q000097:blood* / Q000473:pathology; D007249:Inflammation / Q000097:blood* / Q000473:pathology; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D005340:Fibrinogen
keywords: Essential hypertension; erythrocyte deformability; fibrinogen; interleukin-6; mean corpuscular hemoglobin concentration; red blood cell distribution width