title: [Exploration of one-step preparation of Ganoderma lucidum multicomponent microemulsion].
abstract: To explore one-step method for the preparation of Ganoderma lucidum multicomponent microemulsion, according to the dissolution characteristics of triterpenes and polysaccharides in Ganoderma lucidum, formulation of the microemulsion was optimized. The optimal blank microemulsion was used as a solvent to sonicate the Ganoderma lucidum powder to prepare the multicomponent microemulsion, besides, its physicochemical properties were compared with the microemulsion made by conventional method. The results showed that the multicomponent microemulsion was characterized as (43.32 +/- 6.82) nm in size, 0.173 +/- 0.025 in polydispersity index (PDI) and -(3.98 +/- 0.82) mV in zeta potential. The contents of Ganoderma lucidum triterpenes and polysaccharides were (5.95 +/- 0.32) and (7.58 +/- 0.44) mg x mL(-1), respectively. Sonicating Ganoderma lucidum powder by blank microemulsion could prepare the multicomponent microemulsion. Compared with the conventional method, this method is simple and low cost, which is suitable for industrial production.
authors.affiliation: Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: He
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Meng
authors.initials: M
authors.lastname: Du
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.forename: Ling
authors.initials: L
authors.lastname: Yuan
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Zheng
mesh_terms: D004655:Emulsions; D062610:Fungal Polysaccharides / Q000032:analysis*; D008419:Materia Medica / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D010316:Particle Size; D011208:Powders; D020940:Reishi / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*; D014315:Triterpenes / Q000032:analysis*
chemical_list: D004655:Emulsions; D062610:Fungal Polysaccharides; D008419:Materia Medica; D011208:Powders; D014315:Triterpenes