title: Identification of canine parvovirus with the Q370R point mutation in the VP2 gene from a giant panda (Ailuropoda melanoleuca).
abstract: BACKGROUND
  In this study, we sequenced and phylogenetic analyses of the VP2 genes from twelve canine parvovirus (CPV) strains obtained from eleven domestic dogs and a giant panda (Ailuropoda melanoleuca) in China. A novel canine parvovirus (CPV) was detected from the giant panda in China.
  
  
  RESULTS
  Nucleotide and phylogenetic analysis of the capsid protein VP2 gene classified the CPV as a new CPV-2a type. Substitution of Gln for Arg at the conserved 370 residue in CPV presents an unusual variation in the new CPV-2a amino acid sequence of the giant panda and is further evidence for the continuing evolution of the virus.
  
  
  CONCLUSIONS
  These findings extend the knowledge on CPV molecular epidemiology of particular relevance to wild carnivores.
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Guo
authors.forename: Shao-lin
authors.initials: SL
authors.lastname: Yang
authors.forename: Shi-jie
authors.initials: SJ
authors.lastname: Chen
authors.forename: Zhihe
authors.initials: Z
authors.lastname: Zhang
authors.forename: Chengdong
authors.initials: C
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Hou
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Ren
authors.forename: Xintian
authors.initials: X
authors.lastname: Wen
authors.forename: Sanjie
authors.initials: S
authors.lastname: Cao
authors.forename: Wanzhu
authors.initials: W
authors.lastname: Guo
authors.forename: Zhongxiang
authors.initials: Z
authors.lastname: Hao
authors.forename: Zifang
authors.initials: Z
authors.lastname: Quan
authors.forename: Manli
authors.initials: M
authors.lastname: Zhang
authors.forename: Qi-gui
authors.initials: QG
authors.lastname: Yan
mesh_terms: D000818:Animals; D002681:China; D016000:Cluster Analysis; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D004285:Dogs; D019143:Evolution, Molecular; D008969:Molecular Sequence Data; D050505:Mutant Proteins / Q000235:genetics; D020125:Mutation, Missense; D017993:Parvovirus, Canine / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D010802:Phylogeny; D017354:Point Mutation; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D001503:Ursidae / Q000821:virology*; D015678:Viral Structural Proteins / Q000235:genetics*
chemical_list: D004279:DNA, Viral; D050505:Mutant Proteins; D015678:Viral Structural Proteins