title: Synchronous adenocarcinoma and gastrointestinal stromal tumors in the stomach.
abstract: OBJECTIVE
  To review the clinicopathological characteristics of concurrent gastrointestinal stromal tumors (GISTs) and gastric adenocarcinoma.
  
  
  METHODS
  We retrospectively analyzed eight cases of synchronous adenocarcinoma and GIST in the stomach that had been surgically resected with curative intent between March 2003 and December 2008 in Xinhua hospital and Ruijin hospital. The adenocarcinoma was determined to be the primary tumor based on the histological features. The GIST cells were diffusely and strongly positive for CD34 and CD117.
  
  
  RESULTS
  The patients were six men and two women aged 47-80 years (average, 68.6 years). GIST was preoperatively detected in only one patient. The average sizes of the gastric adenocarcinomas and GISTs were 6.000 ± 2.6186 cm and 1.825 ± 1.4370 cm, respectively. All GISTs were very low- or low-risk lesions that were detected during evaluation, staging, operation or follow-up for gastric adenocarcinoma.
  
  
  CONCLUSIONS
  We hypothesized that the stomach was influenced by the same unknown carcinogen, resulting in a simultaneous proliferation of different cell lines (epithelial and stromal cell).
authors.affiliation: Department of Radiochemotherapy, Rui Jin Hospital, Shanghai Jiaotong University Medical School, Shanghai 200092, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Cai
authors.forename: Gang
authors.initials: G
authors.lastname: Ren
authors.forename: Deng-Bin
authors.initials: DB
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D049109:Cell Proliferation; D005260:Female; D005743:Gastrectomy; D046152:Gastrointestinal Stromal Tumors / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D047368:Tumor Burden
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit
keywords: Gastrectomy; Gastric adenocarcinoma; Gastrointestinal stromal tumor; Synchronous occurrence