title: [Fibrinogen-thrombin as bridge therapy in massive hemoptysis].
abstract: This article presents the case of a young woman with massive hemoptysis (1,000 mL in 6 hours) due to tuberculosis, which could not be controlled by insertion of a Fogarty catheter through a fiber-optic bronchoscope. Because of asphyxia and persistent bleeding risk we instilled fibrinogen-thrombin through a fiber-optic bronchoscope inserted catheter, achieving bleeding cessation and permitting the placing of a double-lumen oro-tracheal tube. Later on, the patient underwent lobectomy and anti-tuberculosis treatment. The fibrinogen-thrombin could be considered as a bridge, transitory measure for massive hemoptysis, while definitive treatment could be established.
authors.affiliation: Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Sabana, Bogotá, D.C., Colombia.
authors.forename: Francisco
authors.initials: F
authors.lastname: Cuervo
authors.forename: Luis F
authors.initials: LF
authors.lastname: Giraldo
authors.forename: Carlos
authors.initials: C
authors.lastname: Vélez
authors.forename: María R
authors.initials: MR
authors.lastname: Forero
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D007611:Aprotinin / Q000008:administration & dosage / Q000627:therapeutic use*; D021721:Balloon Occlusion; D001999:Bronchoscopy / Q000379:methods; D057785:Catheters; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000295:instrumentation; D003131:Combined Modality Therapy; D004338:Drug Combinations; D004630:Emergencies; D005176:Factor XIII / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005336:Fiber Optic Technology; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage / Q000627:therapeutic use*; D005340:Fibrinogen / Q000008:administration & dosage / Q000627:therapeutic use*; D006469:Hemoptysis / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D006489:Hemostatic Techniques / Q000295:instrumentation; D006801:Humans; D007442:Intubation, Intratracheal / Q000295:instrumentation; D011013:Pneumonectomy; D013917:Thrombin / Q000008:administration & dosage / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy / Q000601:surgery
chemical_list: D000995:Antitubercular Agents; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; C586540:beriplast P combi set; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin