title: [Randomized controlled trials terminated prematurely: beneficial therapy effects].
abstract: Randomized controlled trials (RCTs) stopped prematurely for beneficial therapy effects are becoming increasingly more prevalent in the urological literature and often receive great attention in the public and medical media. Urologists who practice evidence-based medicine should be aware of the potential bias and the different reasons why and how early termination of RCTs can and will affect the results. This review provides insights into the challenges clinical urologists face by interpreting the results of prematurely terminated RCTs.
authors.affiliation: Klinik für Urologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
authors.forename: L A
authors.initials: LA
authors.lastname: Kluth
authors.forename: M
authors.initials: M
authors.lastname: Rink
authors.forename: S A
authors.initials: SA
authors.lastname: Ahyai
authors.forename: M
authors.initials: M
authors.lastname: Fisch
authors.forename: S F
authors.initials: SF
authors.lastname: Shariat
authors.forename: P
authors.initials: P
authors.lastname: Dahm
mesh_terms: D015982:Bias; D019317:Evidence-Based Medicine; D006801:Humans; D017063:Outcome Assessment, Health Care / Q000379:methods* / Q000706:statistics & numerical data*; D010820:Physicians / Q000706:statistics & numerical data*; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000706:statistics & numerical data*