title: Flurbiprofen-induced generalized bullous fixed drug eruption.
abstract: Fixed drug eruption (FDE) is an unusual drug-related side effect that results in recurrent lesions whenever the causative drugs are used. FDEs usually occur as a single, sharply demarcated, round erythematous patch or plaque, occasionally with localized bullae. The most common offending agents include antimicrobials, nonsteroidal anti-inflammatory drugs, and antiepileptics. There are some reports where contact dermatitis and cutaneous vasculitis have been associated with the use of flurbiprofen. We present the case of a 50-year-old man with flurbiprofen-induced generalized bullous FDE. To the best of our knowledge, the most serious form of FDE, the generalized bullous FDE, to be caused by flurbiprofen has not been reported previously.
authors.affiliation: 1Department of Dermatology, Kecioren Training and Research Hospital, Ministry of Health, Ankara, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Balta
authors.forename: H
authors.initials: H
authors.lastname: Simsek
authors.forename: G G
authors.initials: GG
authors.lastname: Simsek
mesh_terms: D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001768:Blister / Q000209:etiology; D003131:Combined Modality Therapy; D003875:Drug Eruptions / Q000188:drug therapy / Q000503:physiopathology*; D005121:Extremities; D005480:Flurbiprofen / Q000009:adverse effects*; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012720:Severity of Illness Index; D013256:Steroids / Q000008:administration & dosage / Q000627:therapeutic use; D060726:Torso; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006633:Histamine Antagonists; D013256:Steroids; D005480:Flurbiprofen
keywords: Fixed drug eruption; bullous; flurbiprofen; generalized