title: Iridium-catalyzed enantioselective allylic alkynylation.
abstract: No leaving group needed: With an Ir(P,olefin) complex as catalyst, the direct enantioselective allylic alkynylation of secondary allylic alcohols with potassium alkynyltrifluoroborates as alkynylating reagents has been achieved. High levels of enantioselectivity and high yields were achieved with this operationally easy and robust protocol, the use of which was demonstrated in the synthesis of GPR40 receptor agonist AMG 837. cod = 1,5-cyclooctadiene.
authors.affiliation: ETH Zürich, HCI H335, 8093 Zürich, Switzerland.
authors.forename: James Y
authors.initials: JY
authors.lastname: Hamilton
authors.forename: David
authors.initials: D
authors.lastname: Sarlah
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira
keywords: alkynes; alkynyltrifluoroborates; allylic substitution; enantioselectivity; iridium