title: Insulin oedema in a child with newly diagnosed diabetes mellitus.
abstract: Insulin oedema is a rare complication of insulin therapy for diabetes mellitus. It has been reported in type 1 diabetes mellitus, in poorly controlled type 2 diabetes mellitus following either the initiation or intensification of insulin therapy and in underweight patients on large doses of insulin. There are only a few case reports since it was first described in 1928, showing that it is an uncommon and probably an under-reported complication. The majority of those reports have been in the adult population. The generalised oedema tends to develop shortly after initiation or intensification of insulin therapy and resolves spontaneously within few weeks. We present one of the youngest patients reported in the literature, a 9-year-old boy who developed insulin oedema within few days of presenting with diabetic ketoacidosis. The case highlights the importance of recognising this generally transient and self-resolving complication and differentiating it from other serious causes of oedema.
authors.affiliation: Department of Paediatrics, Royal Blackburn Hospital, East Lancashire Hospitals NHS Trust, Blackburn, BB2 3HH, UK.
authors.forename: Avinash
authors.initials: A
authors.lastname: Aravamudhan
authors.forename: Chris
authors.initials: C
authors.lastname: Gardner
authors.forename: Claire
authors.initials: C
authors.lastname: Smith
authors.forename: Senthil
authors.initials: S
authors.lastname: Senniappan
mesh_terms: D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy*; D016883:Diabetic Ketoacidosis / Q000150:complications*; D003937:Diagnosis, Differential; D004487:Edema / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007328:Insulin / Q000009:adverse effects*; D008297:Male
chemical_list: D007328:Insulin