title: Nodular hidradenoma of the caruncle.
abstract: An 84-year-old man presented with a tumor of the right caruncle causing epiphora due to insufficient eyelid closure. The tumor was cystic and mucinous in appearance. MRI showed a solitary tumor of the caruncle with no adhesions to neighboring tissue. The mass was removed by carunculectomy. Histopathologic examination revealed a tumor composed of epithelial cells with intervening strands of hyalinized stroma. Solid areas were predominant but a cribriform area could also be distinguished. Periodic acid-Schiff positive, diastase-labile material (glycogen) was detected in many tumor cells. Immunohistochemical staining of the tumor cells demonstrated positive staining with antibodies against CK-CAM 5.2, BER-EP4, p63, and smooth muscle actin-positive cells in some areas. The tumor was diagnosed as a nodular hidradenoma of the caruncle, which has never been reported before and should be included in the diagnoses of caruncular tumors.
authors.affiliation: *Department of Ophthalmology, Glostrup and Hillerød Hospital; and †Department of Neuroscience and Pharmacology, Eye Pathology Institute, University of Copenhagen, Denmark.
authors.forename: Christos
authors.initials: C
authors.lastname: Christakopoulos
authors.forename: Jan Ulrik
authors.initials: JU
authors.lastname: Prause
authors.forename: Steffen
authors.initials: S
authors.lastname: Heegaard
mesh_terms: D018250:Acrospiroma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D003230:Conjunctival Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005142:Eyelid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013508:Ophthalmologic Surgical Procedures; D013544:Sweat Gland Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor