title: Severe postoperative hemorrhage caused by antibody-mediated coagulation factor deficiencies: report of two cases.
abstract: Antibody-mediated coagulation factor deficiencies constitute a rare disorder that may develop in elderly patients without any history of a bleeding diathesis. Patients may present with severe and sometimes catastrophic bleeding. We report two cases of postoperative hemorrhage caused by a coagulation factor deficiency. In Case 1, massive intraabdominal bleeding occurred on day 3 after pancreaticoduodenectomy for bile duct cancer, and was caused by an acquired inhibitor of coagulation factor VIII. Hemostasis was achieved and the factor VIII inhibitor titer decreased to zero with activated prothrombin complex concentrates, prednisolone, and cyclophosphamide. In Case 2, intraabdominal bleeding occurred on day 7 after hepatectomy for hepatocellular carcinoma, and was caused by an acquired inhibitor against factors II (prothrombin) and V. This patient was treated with hemostatic agents containing bovine thrombin during surgery and also with prednisolone. We report these cases to highlight that antibody-mediated coagulation factor deficiencies should be considered when an elderly patient suffers sudden postoperative hemorrhage and to stress the importance of prompt diagnosis because of the risk of potentially life-threatening hemorrhage.
authors.affiliation: Department of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Miura
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ban
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Koyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kudo
authors.forename: Takanori
authors.initials: T
authors.lastname: Ochiai
authors.forename: Takumi
authors.initials: T
authors.lastname: Irie
authors.forename: Noriaki
authors.initials: N
authors.lastname: Nakamura
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanaka
authors.forename: Shigeki
authors.initials: S
authors.lastname: Arii
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D005166:Factor V Deficiency / Q000150:complications* / Q000276:immunology*; D005169:Factor VIII / Q000276:immunology*; D006467:Hemophilia A / Q000150:complications* / Q000276:immunology*; D006801:Humans; D007020:Hypoprothrombinemias / Q000150:complications* / Q000276:immunology*; D008297:Male; D019106:Postoperative Hemorrhage / Q000209:etiology*; D011516:Prothrombin / Q000276:immunology*; D012720:Severity of Illness Index
chemical_list: D001323:Autoantibodies; D011516:Prothrombin; D005169:Factor VIII