title: Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera.
abstract: Two new triterpenoids, schisphendilactone A and B (1 and 2), together with three known triterpenoids, were isolated from the stems of Schisandra sphenanthera. Their structures were elucidated by spectroscopic methods, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 2 showed moderate inhibitory activity against SW480 cancer cell line, and compound 5 exhibited promising anti-HIV-1 activity with EC50 value of 0.52 μg ml(-1) and therapeutic index value of 117.12.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.
authors.forename: Cheng-Qin
authors.initials: CQ
authors.lastname: Liang
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Luo
authors.forename: Ju-Ming
authors.initials: JM
authors.lastname: Yan
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Shi
authors.forename: Shan-Zhai
authors.initials: SZ
authors.lastname: Shang
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Gao
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Zhang
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D019380:Anti-HIV Agents / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D003588:Cytopathogenic Effect, Viral; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*; D013237:Stereoisomerism; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014315:Triterpenes