title: Analysis of macular cone photoreceptors in a case of occult macular dystrophy.
abstract: OBJECTIVE
  To investigate changes in cone photoreceptors with adaptive optics (AO) fundus imaging and spectral domain optical coherence tomography (SD-OCT) in a case of occult macular dystrophy (OMD).
  
  
  METHODS
  Both eyes of a 42-year-old woman diagnosed with OMD were examined. We used an AO fundus camera to obtain images of cone photoreceptors in the macula of the OMD subject and five healthy control subjects. Correlations between the AO images and the SD-OCT images were examined. Cone photoreceptors in eight areas in the macula of OMD and healthy control subjects were analyzed and compared.
  
  
  RESULTS
  SD-OCT showed a loss of the cone outer-segment tips line outside of the fovea in both eyes of the subject with OMD. The left eye with decreased visual acuity showed a discontinuous photoreceptor inner-segment and outer-segment line and cone outer-segment tips line at the fovea in SD-OCT and loss of cone mosaics as a dark spot in the AO image. In panoramic AO images and cone-density maps, less cone density was observed in a ring-like region outside the fovea than in the peripheral retina. In most of the areas examined, the cone densities were lower in the OMD eyes than in the healthy control eyes.
  
  
  CONCLUSIONS
  Cone densities in the macula of the OMD patient were greatly decreased. AO images were found to be useful to evaluate morphologic changes in cone photoreceptors in patients with OMD.
authors.affiliation: Department of Ophthalmology, University of Toyama, Toyama, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Tojo
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakamura
authors.forename: Hironori
authors.initials: H
authors.lastname: Ozaki
authors.forename: Miyako
authors.initials: M
authors.lastname: Oka
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Oiwake
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hayashi
keywords: adaptive optics; cone analysis; cone photoreceptor; occult macular dystrophy; optical coherence tomography