title: Highly regioselective C2-alkenylation of indoles using the N-benzoyl directing group: an efficient Ru-catalyzed coupling reaction.
abstract: A highly regioselective alkenylation of indole at the C2-position has been achieved using the Ru(II) catalyst by employing a directing group strategy. This strategy offers rare selectivity for the alkenylation N-benzoylindole at the C-2 position in the presence of the more active C3- and C7-position of indole and the ortho-positions of the benzoyl protecting group. A simple deprotection of the benzoyl group has also been exemplified, and the resulting product serves as a useful synthon for natural product syntheses.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore-560012, Karnataka, India.
authors.forename: Veeranjaneyulu
authors.initials: V
authors.lastname: Lanke
authors.forename: Kandikere Ramaiah
authors.initials: KR
authors.lastname: Prabhu