title: Backbone resonance assignment of Alt a 1, a unique β-barrel protein and the major allergen of Alternaria alternata.
abstract: Alt a 1 is the major allergen of the fungus Alternaria alternata and can be found in the cell wall of its spores. It is a cysteine linked homodimeric protein with a unique β-barrel fold as recently revealed by X-ray crystallography. Despite the elucidation of its structure, its biological function remains unknown. For Alternaria-sensitized patients, contact leads to respiratory allergy and in severe cases to asthma-related death. Here we report the sequence-specific Alt a 1 backbone (1)H, (15)N and (13)C chemical shift assignment.
authors.affiliation: Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, 8010, Graz, Austria.
authors.forename: Gabriel E
authors.initials: GE
authors.lastname: Wagner
authors.forename: Sandra
authors.initials: S
authors.lastname: Gutfreund
authors.forename: Kerstin
authors.initials: K
authors.lastname: Fauland
authors.forename: Walter
authors.initials: W
authors.lastname: Keller
authors.forename: Rudolf
authors.initials: R
authors.lastname: Valenta
authors.forename: Klaus
authors.initials: K
authors.lastname: Zangger
mesh_terms: D000485:Allergens; D000528:Alternaria; D005656:Fungal Proteins / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D017433:Protein Structure, Secondary; D013997:Time Factors
chemical_list: D000485:Allergens; D005656:Fungal Proteins