title: Fluorescent probes for live cell imaging of endogenous Guanine nitration.
abstract: Seeing is believing: S-guanylation is a novel key mechanism by which signal transduction under oxidative stress is regulated. A chemical probe whose fluorescent intensity increases after the reaction with proteinous cysteine (S-guanylation) is described. The use of this probe revealed that S-guanylation products localized in lysosomes.
authors.affiliation: Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba, Sendai 980-8577, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Saito
authors.forename: Chiaki
authors.initials: C
authors.lastname: Ito
authors.forename: Shigemoto
authors.initials: S
authors.lastname: Fujii
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sawa
authors.forename: Takaaki
authors.initials: T
authors.lastname: Akaike
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Arimoto
mesh_terms: D000818:Animals; D001386:Azides / Q000737:chemistry; D002460:Cell Line; D003374:Coumarins / Q000737:chemistry; D003545:Cysteine / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008247:Lysosomes / Q000378:metabolism; D051379:Mice; D008856:Microscopy, Fluorescence; D009569:Nitric Oxide / Q000737:chemistry*
chemical_list: D001386:Azides; D003374:Coumarins; D005456:Fluorescent Dyes; D009569:Nitric Oxide; D006147:Guanine; D003545:Cysteine