title: Therapeutic effect of total ginseng saponin on skin wound healing.
abstract: In this study, we investigated the effects of total ginseng saponin (TGS) on the cutaneous wound healing process using histological analysis. A total of 24 ICR mice, 5-weeks-old, were used for all in vivo experiments. Mice were divided into control and TGS-treated groups and four equidistant 1-cm full-thickness dorsal incisional wounds were created. The wounds were extracted at days 1, 3, 5, and 7 post-injury for histomorphometrical analysis including wound area and contracture measurements, keratinocyte migration rate, and calculation of infiltrating inflammatory cells. The results showed that the wound area was smaller and keratinocyte migration rate was higher in the TGS-treated group than that of the control group from days 3 to 7. Inflammatory cells in the TGS-treated group at days 1 and 3 were reduced compared to the control group. Wound contraction in the TGS-treated group was greater than in the control group on days 3 to 5, and collagen deposition in the TGS-treated group was higher than in the control group during wound healing. The results indicate a beneficial effect of TGS when used to treat skin wounds.
authors.affiliation: Department of Veterinary Surgery, Chonnam National University College of Veterinary Medicine, Gwangju 500-757, Korea.
authors.forename: Young Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Ik-Hyun
authors.initials: IH
authors.lastname: Cho
authors.forename: Moon-Jin
authors.initials: MJ
authors.lastname: Jeong
authors.forename: Soon-Jeong
authors.initials: SJ
authors.lastname: Jeong
authors.forename: Seung Yeol
authors.initials: SY
authors.lastname: Nah
authors.forename: Young-Sik
authors.initials: YS
authors.lastname: Cho
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Ara
authors.initials: A
authors.lastname: Go
authors.forename: Se Eun
authors.initials: SE
authors.lastname: Kim
authors.forename: Seong Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Chang Jong
authors.initials: CJ
authors.lastname: Moon
authors.forename: Jong Choon
authors.initials: JC
authors.lastname: Kim
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Chun Sik
authors.initials: CS
authors.lastname: Bae
keywords: Mice; Panax ginseng; Skin wound healing; Total ginseng saponin