title: A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls.
abstract: OBJECTIVE
  To identify plasma uric acid-related genes in extremely obese and normal weight individuals using genome-wide association studies (GWASs).
  
  
  METHODS
  Using genotypes from a GWAS focusing on obesity and thinness, quantitative trait association analyses (PLINK) for plasma uric acid levels in 1,060 extremely obese individuals (BMI > 35 kg/m2) and normal-weight controls (BMI < 25 kg/m2) were performed. In 961 samples with uric acid data, 924 were females.
  
  
  RESULTS
  Significant associations were found in SLC2A9 gene SNPs and plasma uric acid levels (rs6449213, P = 3.15 × 10(-12) ). DIP2C gene SNP rs877282 also reached genome-wide significance (P = 4.56 × 10(-8)). Weaker associations (P < 1× 10(-5)) were found in F5, PXDNL, FRAS1, LCORL, and MICAL2 genes. Besides SLC2A9, three previously identified uric acid-related genes ABCG2 (rs2622605, P= 0.0026), SLC17A1 (rs3799344, P = 0.0017), and RREB1 (rs1615495, P = 0.00055) received marginal support in our study.
  
  
  CONCLUSIONS
  Two genes/chromosome regions reached genome-wide association significance (P < 1 × 10(-7) , 550 K SNPs) in our GWAS: SLC2A9, the chromosome 2 60.1 Mb region (rs6723995), and the DIP2C gene region. Five other genes (F5, PXDNL, FRAS1, LCORL, and MICAL2) yielded P < 1 × 10(-5) . Four previous reported associations were replicated in our study, including SLC2A9, ABCG2, RREB, and SLC17A1.
authors.affiliation: Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Li
authors.forename: Hongxiao
authors.initials: H
authors.lastname: Jiao
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.forename: Clarence K
authors.initials: CK
authors.lastname: Zhang
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Glessner
authors.forename: Struan F A
authors.initials: SF
authors.lastname: Grant
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhao
authors.forename: Hakon
authors.initials: H
authors.lastname: Hakonarson
authors.forename: R
authors.initials: R
authors.lastname: Arlen Price
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002877:Chromosomes, Human; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D051246:Glucose Transport Proteins, Facilitative; C411811:SLC2A9 protein, human; D014527:Uric Acid