title: Double functionalization of carbon nanotubes with purine and pyrimidine derivatives.
abstract: Herein, we have developed a synthetic strategy for the covalent double functionalization of single-walled carbon nanotubes (SWCNTs) with a combination of purine-pyrimidine and purine-purine nucleobase systems. The nucleobases were introduced on the sidewall of oxidized SWCNTs through 1,3-dipolar cycloaddition and by amidation of the carboxylic acids located at the tips and defect sites of the nanotubes. The new nanohybrids were characterized by transmission electron microscopy, thermogravimetric analysis, FTIR and Raman spectroscopy, magic-angle spinning NMR spectroscopy, and Kaiser test. The nucleobase/SWCNT conjugates can be envisaged for the modulation of the interactions with nucleic acids by means of base pairing, thereby opening new possibilities in the development of DNA/CNT nanobioconjugates.
authors.affiliation: CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg, France. prabhpreet1979@gmail.com
authors.forename: Prabhpreet
authors.initials: P
authors.lastname: Singh
authors.forename: Cécilia
authors.initials: C
authors.lastname: Ménard-Moyon
authors.forename: Alessia
authors.initials: A
authors.lastname: Battigelli
authors.forename: Francesca Maria
authors.initials: FM
authors.lastname: Toma
authors.forename: Jesus
authors.initials: J
authors.lastname: Raya
authors.forename: Jitendra
authors.initials: J
authors.lastname: Kumar
authors.forename: Nagapradeep
authors.initials: N
authors.lastname: Nidamanuri
authors.forename: Sandeep
authors.initials: S
authors.lastname: Verma
authors.forename: Alberto
authors.initials: A
authors.lastname: Bianco
mesh_terms: D002264:Carboxylic Acids; D061565:Cycloaddition Reaction; D004247:DNA / Q000737:chemistry; D037742:Nanotubes, Carbon / Q000737:chemistry*; D011684:Purine Nucleosides / Q000737:chemistry*; D011741:Pyrimidine Nucleosides / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D037742:Nanotubes, Carbon; D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides; D004247:DNA