title: Design and synthesis of mimics of the T7-loop of FtsZ.
abstract: Mimics of the T7-loop of the bacterial cell division protein FtsZ have been designed and synthesized. The design is based on the X-ray cocrystal structure of P. aeruginosa FtsZ:SulA. Fast Rigid Exhaustive Docking (FRED) was employed to select compounds that can mimic the key interacting residues. Bicyclic oxazolidinones 1a-d were selected for further study and synthesized from a key bicyclic aziridine intermediate, which is synthesized from a readily available unsaturated aldehyde and amides derived from α-amino acids.
authors.affiliation: Department of Chemistry, One Shields Ave, University of California, Davis, California 95616, USA.
authors.forename: Nohemy A
authors.initials: NA
authors.lastname: Sorto
authors.forename: Phillip P
authors.initials: PP
authors.lastname: Painter
authors.forename: James C
authors.initials: JC
authors.lastname: Fettinger
authors.forename: Dean J
authors.initials: DJ
authors.lastname: Tantillo
authors.forename: Jared T
authors.initials: JT
authors.lastname: Shaw
mesh_terms: D000595:Amino Acid Sequence; D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry*; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D002455:Cell Division / Q000502:physiology; D018360:Crystallography, X-Ray; D003598:Cytoskeletal Proteins / Q000737:chemistry* / Q000378:metabolism; D004926:Escherichia coli / Q000737:chemistry* / Q000166:cytology; D008958:Models, Molecular; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry; D011485:Protein Binding; D011550:Pseudomonas aeruginosa
chemical_list: D001388:Aziridines; D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria; D023303:Oxazolidinones