title: The relationship between angiotensinogen gene polymorphisms and essential hypertension in a Northern Han Chinese population.
abstract: Gene polymorphisms of the renin-angiotensin system are involved in the pathophysiology of hypertension. We genotyped 4 polymorphisms of angiotensinogen (AGT) gene A-20C (rs5050), A-6G (rs5051), C3889T (rs4762), and C4072T (rs699) by polymerase chain reaction-restriction fragment length polymorphism in 652 patients and 780 controls to examine the association of AGT and hypertension in a Northern Han Chinese population. There were significant differences in the distribution of genotypes and allele frequencies at C4072T between the patients and the controls (both P < .01); patients with CC genotype had a higher risk of hypertension (odds ratio = 1.7, 95% confidence interval 1.4-2.1). The distribution of genotypes at A-6G was significantly different between patients and controls (P < .05). No other significant differences in genotypes or frequencies were observed. No association was observed between the haplotypes of AGT and hypertension. The AGT-6A and 4072C alleles are associated with susceptibility to hypertension in this population.
authors.affiliation: Institute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Du
authors.affiliation: Department of Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Wu
authors.affiliation: Institute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Institute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Jingping
authors.initials: J
authors.lastname: Li
authors.affiliation: Institute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Mingyu
authors.initials: M
authors.lastname: Cong
authors.affiliation: Institute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
authors.forename: Jicheng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Institute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China Department of Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China changchun_qiu@163.com.
authors.forename: Changchun
authors.initials: C
authors.lastname: Qiu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000808:Angiotensinogen / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D000075222:Essential Hypertension; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012084:Renin-Angiotensin System / Q000235:genetics*
chemical_list: D000808:Angiotensinogen
keywords: A-20C; A-6G; C3889T; C4072T; Northern Han Chinese population; angiotensinogen; essential hypertension