title: Formation of rutile fasciculate zone induced by sunlight irradiation at room temperature and its hemocompatibility.
abstract: The fasciculate zone of phase pure rutile was fabricated under sunlight irradiation at room temperature, using titanium tetrachloride as a sole precursor. The crystal phase, morphology and microstructure, and optical absorption behavior of the samples were characterized by X-ray Diffraction, High-Resolution Transmission Electron Microscope (HRTEM) and UV-vis Diffuse Reflectance Spectra (DRS), respectively. XRD results show that the crystal phase of the sample is composed of rutile only, and a lattice distortion displays in the crystallite of the sample. HRTEM results show that the morphology of rutile particle is fasciculate zone constituted of nanoparticles with a diameter of 4-7 nm, and these particles grow one by one and step by step. The pattern of the selected area electron diffraction of the sample is Kikuchi type, which can be attributed to the predominant orientation growth of rutile nanoparticles along [001] induced by sunlight irradiation. DRS results show that the absorption threshold of the sample is 415 nm, corresponding to the band gap energy of 2.99 eV, which is lower than the band gap energy of rutile, 3.03 eV. Blood compatibility measurement shows that the sample has no remarkable effect on hemolytic and coagulation activity. The percent hemolysis of red blood cells is less than 5% even treated with a big dosage of the fasciculate rutile and under UV irradiation, and there are no obvious changes of plasma recalcification time after the rutile treatment. Thus, the novel structure of rutile fasciculate has low potential toxicity for blood and is hemocompatibility safe.
authors.affiliation: School of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Xuan-Hui
authors.initials: XH
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Zheng
authors.forename: Yuan
authors.initials: Y
authors.lastname: Cheng
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Li
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Chen
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Zheng
mesh_terms: D000042:Absorption; D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006461:Hemolysis; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity / Q000648:ultrastructure; D010316:Particle Size; D012756:Sheep; D013472:Sunlight; D013696:Temperature; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: C009495:titanium dioxide; C025096:titanium tetrachloride; D014025:Titanium