title: Long-term health experience of jet engine manufacturing workers: VI: incidence of malignant central nervous system neoplasms in relation to estimated workplace exposures.
abstract: OBJECTIVE
  To determine whether glioblastoma (GB) incidence rates among jet engine manufacturing workers were associated with specific chemical or physical exposures.
  
  
  METHODS
  Subjects were 210,784 workers employed from 1952 to 2001. We conducted a cohort incidence study and two nested case-control studies with focus on the North Haven facility where we previously observed a not statistically significant overall elevation in GB rates. We estimated individual-level exposure metrics for 11 agents.
  
  
  RESULTS
  In the total cohort, none of the agent metrics considered was associated with increased GB risk. The GB incidence rates in North Haven were also not related to workplace exposures, including the "blue haze" exposure unique to North Haven.
  
  
  CONCLUSIONS
  If not due to chance alone, GB rates in North Haven may reflect external occupational factors, nonoccupational factors, or workplace factors unique to North Haven unmeasured in the current evaluation.
authors.affiliation: Center for Occupational Biostatistics and Epidemiology, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. gmarsh@cobe.pitt.edu
authors.forename: Gary M
authors.initials: GM
authors.lastname: Marsh
authors.forename: Ada O
authors.initials: AO
authors.lastname: Youk
authors.forename: Jeanine M
authors.initials: JM
authors.lastname: Buchanich
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
authors.forename: Sarah
authors.initials: S
authors.lastname: Downing
authors.forename: Kathleen J
authors.initials: KJ
authors.lastname: Kennedy
authors.forename: Nurtan A
authors.initials: NA
authors.lastname: Esmen
authors.forename: Roger P
authors.initials: RP
authors.lastname: Hancock
authors.forename: Steven E
authors.initials: SE
authors.lastname: Lacey
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Fleissner
mesh_terms: D000328:Adult; D000401:Aircraft; D016022:Case-Control Studies; D016543:Central Nervous System Neoplasms / Q000453:epidemiology*; D015331:Cohort Studies; D003237:Connecticut / Q000453:epidemiology; D004574:Electromagnetic Fields; D005909:Glioblastoma / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007221:Industry / Q000706:statistics & numerical data*; D008223:Lymphoma / Q000453:epidemiology*; D019216:Metals, Heavy; D009784:Occupational Diseases / Q000453:epidemiology*; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D011078:Polychlorinated Biphenyls; D011839:Radiation, Ionizing; D012997:Solvents; D013997:Time Factors; D055815:Young Adult
chemical_list: D019216:Metals, Heavy; D012997:Solvents; D011078:Polychlorinated Biphenyls