title: Inflammation marker, damage marker and anabolic hormone responses to resistance training with vascular restriction in older males.
abstract: The goal of this study was to examine anabolic hormone, muscle damage marker and inflammation marker responses to two types of resistance training protocols in older men. Thirty-six healthy older males (mean age = 56.6 ± 0.6 years) completed 6 weeks of high-intensity resistance training (HI-RT), low-intensity resistance training with vascular restriction (LI-BFR) or no exercise control group (CON) three times per week. Three upper body exercises were performed by both exercise groups at the same intensity (at 80% 1-RM), but lower body exercises were performed by the HI-RT group at 80% 1-RM and by the LI-BFR group at 20% 1-RM with vascular restriction. Resting serum creatine kinase (CK), interleukin 6 (IL-6), insulin-like growth factor-I (IGF-I), IGF binding protein 3 (IGFBP-3) and testosterone (T) were measured before and after training. No significant group differences in resting CK, IL-6, IGF-I, IGFBP-3 and T were detected following training (P>0.05). In addition, there were no significant changes in muscle cross-sectional area (CSA), but a trend for significant decreases in the percent changes in thigh subcutaneous fat (P = 0.051). Although training-induced anabolic hormone response did not reach statistical significance, our findings on CK and IL-6 indicated that the LI-BFR training protocol was safe and well tolerated for older men to perform to improve muscular strength.
authors.affiliation: Department of Health and Human Performance, University of Texas at Brownsville, Brownsville, TX 78520, USA. murat.karabulut@utb.edu
authors.forename: Murat
authors.initials: M
authors.lastname: Karabulut
authors.forename: Vanessa D
authors.initials: VD
authors.lastname: Sherk
authors.forename: Debra A
authors.initials: DA
authors.lastname: Bemben
authors.forename: Michael G
authors.initials: MG
authors.lastname: Bemben
mesh_terms: D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000201:enzymology / Q000276:immunology / Q000378:metabolism*; D012039:Regional Blood Flow; D055070:Resistance Training / Q000009:adverse effects; D013739:Testosterone / Q000097:blood*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014111:Tourniquets / Q000009:adverse effects
chemical_list: D015415:Biomarkers; C583557:IGF1 protein, human; C515497:IGFBP3 protein, human; C508600:IL6 protein, human; D018836:Inflammation Mediators; D018972:Insulin-Like Growth Factor Binding Protein 3; D015850:Interleukin-6; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D003402:Creatine Kinase
keywords: blood flow restriction; inflammation marker; muscle damage; resistance training; testosterone