title: Protein kinase inhibitors: breakthrough medicines and the next generation.
abstract: In this issue of Expert Opinion on Investigational Drugs, several protein kinases families and pathways underlying cancer and other diseases are reviewed and several small molecule inhibitors that are in clinical trials are further described. Highlights of these reviews and drug evaluations are summarized in this editorial.
authors.forename: Tomi K
authors.initials: TK
authors.lastname: Sawyer
authors.forename: Joe C
authors.initials: JC
authors.lastname: Wu
authors.forename: Jonathon R
authors.initials: JR
authors.lastname: Sawyer
authors.forename: Jessie M
authors.initials: JM
authors.lastname: English
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D015195:Drug Design; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011494:Protein Kinases / Q000187:drug effects* / Q000378:metabolism
chemical_list: D047428:Protein Kinase Inhibitors; D011494:Protein Kinases