title: Preparation of water-soluble hyperbranched polyester nanoparticles with sulfonic acid functional groups and their micelles behavior, anticoagulant effect and cytotoxicity.
abstract: Biocompatibility of nanoparticles has been attracting great interest in the development of nanoscience and nanotechnology. Herein, the aliphatic water-soluble hyperbranched polyester nanoparticles with sulfonic acid functional groups (HBPE-SO3 NPs) were synthesized and characterized. They are amphiphilic polymeric nanoparticles with hydrophobic hyperbranched polyester (HBPE) core and hydrophilic sulfonic acid terminal groups. Based on our observations, we believe there are two forms of HBPE-SO3 NPs in water under different conditions: unimolecular micelles and large multimolecular micelles. The biocompatibility and anticoagulant effect of the HBPE-SO3 NPs were investigated using coagulation tests, hemolysis assay, morphological changes of red blood cells (RBCs), complement and platelet activation detection, and cytotoxicity (MTT). The results confirmed that the sulfonic acid terminal groups can substantially enhance the anticoagulant property of HBPE, and the HBPE-SO3 NPs have the potential to be used in nanomedicine due to their good bioproperties.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, Biomedical Functional Materials Collaborative Innovation Center, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Qiaorong
authors.initials: Q
authors.lastname: Han
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Chen
authors.forename: Yanlian
authors.initials: Y
authors.lastname: Niu
authors.forename: Bo
authors.initials: B
authors.lastname: Zhao
authors.forename: Bingxiang
authors.initials: B
authors.lastname: Wang
authors.forename: Chun
authors.initials: C
authors.lastname: Mao
authors.forename: Libin
authors.initials: L
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003167:Complement Activation / Q000187:drug effects; D003165:Complement System Proteins / Q000819:agonists; D004912:Erythrocytes / Q000187:drug effects; D057809:HEK293 Cells; D006461:Hemolysis / Q000187:drug effects; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry*; D011817:Rabbits; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D008823:Micelles; D011091:Polyesters; D013451:Sulfonic Acids; D003165:Complement System Proteins