title: A case of oligoasthenoteratozoospermia with AZFc deletion and persistent oxidative stress.
abstract: Y-chromosomal microdeletions are associated with severe oligozoospermia or azoospermia. AZFc microdeletions have been always associated with severe oligozoospermia or azoospermia with a rare occurrence in individuals with other infertility phenotypes. We report here a rare case of an infertile man carrying AZFc deletion, whose semen picture is oligoasthenoteratozoospermia complexed with seminal oxidative stress. Anti-oxidant therapy could make no change in either oxidative stress biomarker levels of semen, seminal parameters or serum hormone levels. Therefore, oligoasthenoteratozoospermia in the present case correlates with AZFc deletion, and high content of abnormal sperm eventually might be responsible for persistently elevated reactive oxygen species levels. Understanding the function of genes in AZFc region could help decipher the exact cause of the phenotype in such cases.
authors.affiliation: Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
authors.forename: Rajender
authors.initials: R
authors.lastname: Singh
authors.forename: Ahmad Mohammad
authors.initials: AM
authors.lastname: Kaleem
authors.forename: Sankhwar Satya
authors.initials: SS
authors.lastname: Narayana
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Mahdi
keywords: AZFc deletion; male infertility; oligoasthenoteratozoospermia; oxidative stress