title: Radiographic evaluation of regenerated bone following poly(lactic-co-glycolic) acid/hydroxyapatite and deproteinized bovine bone graft in sinus lifting.
abstract: Although numerous biomaterials are used for maxillary sinus-lift surgery, the ideal material for such procedures has not yet been identified. Both heterologous and alloplastic bone substitutes have a solely osteoconductive effect and lack the osteoinductive properties of the bone morphogenetic proteins typical of autologous bone. Our group assessed a new alloplastic graft material, poly(lactic-co-glycolic) acid/hydroxyapatite (PLGA/HA), implanted in a human model of maxillary sinus-lift surgery. For this prospective, random, double-blind trial, we used deproteinized bovine bone (DBB) as the comparison material. Radiographic bone vertical height and density were assessed at approximately 28 weeks after grafting using cone-beam computed tomography. The vertical dimension of the regenerated bone was equivalent between the 2 groups. The density of the bone regenerated using PLGA/HA was significantly lower than that obtained with DBB. Despite clinical assessments demonstrating that PLGA/HA has sufficient characteristics for use in sinus-lift surgery, DBB provided greater bone density and an equivalent vertical dimension of grafted bone. Further studies are needed to supplement the radiologic findings with histologic and micromorphometric examinations.
authors.affiliation: Department of Clinico Surgical, Diagnostic and Pediatric Sciences, School of Dentistry, Pavia, Italy. ruggero.rodriguez@unipv.it
authors.forename: Ruggero Rodriguez
authors.initials: RR
authors.lastname: Y Baena
authors.forename: Saturnino Marco
authors.initials: SM
authors.lastname: Lupi
authors.forename: Roberta
authors.initials: R
authors.lastname: Pastorino
authors.forename: Carlo
authors.initials: C
authors.lastname: Maiorana
authors.forename: Alessandra
authors.initials: A
authors.lastname: Lucchese
authors.forename: Silvana
authors.initials: S
authors.lastname: Rizzo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D015519:Bone Density / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D054893:Cone-Beam Computed Tomography; D004311:Double-Blind Method; D017886:Durapatite / Q000627:therapeutic use*; D006801:Humans; D019344:Lactic Acid / Q000627:therapeutic use*; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000601:surgery*; D011091:Polyesters; D011108:Polymers / Q000627:therapeutic use*; D011446:Prospective Studies; D059546:Sinus Floor Augmentation / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D017886:Durapatite