title: First screening of Aedes albopictus immunogenic salivary proteins.
abstract: Study of the human antibody (Ab) response to Aedes salivary proteins can provide new biomarkers to evaluate human exposure to vector bites. The identification of genus- and/or species-specific proteins is necessary to improve the accuracy of biomarkers. We analysed Aedes albopictus immunogenic salivary proteins by 2D immunoproteomic technology and compared the profiles according to human individual exposure to Ae. albopictus or Ae. aegypti bites. Strong antigenicity to Ae. albopictus salivary proteins was detected in all individuals whatever the nature of Aedes exposure. Amongst these antigenic proteins, 68% are involved in blood feeding, including D7 protein family, adenosine deaminase, serpin and apyrase. This study provides an insight into the repertoire of Ae. albopictus immunogenic salivary proteins for the first time.
authors.affiliation: MIVEGEC: Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle, , Universities of Montpellier 1 and 2., Montpellier, France. souleymane.doucoure@ird.fr
authors.forename: S
authors.initials: S
authors.lastname: Doucoure
authors.forename: S
authors.initials: S
authors.lastname: Cornelie
authors.forename: S
authors.initials: S
authors.lastname: Patramool
authors.forename: F
authors.initials: F
authors.lastname: Mouchet
authors.forename: E
authors.initials: E
authors.lastname: Demettre
authors.forename: M
authors.initials: M
authors.lastname: Seveno
authors.forename: J S
authors.initials: JS
authors.lastname: Dehecq
authors.forename: H
authors.initials: H
authors.lastname: Rutee
authors.forename: J P
authors.initials: JP
authors.lastname: Herve
authors.forename: F
authors.initials: F
authors.lastname: Favier
authors.forename: D
authors.initials: D
authors.lastname: Missé
authors.forename: P
authors.initials: P
authors.lastname: Gasque
authors.forename: F
authors.initials: F
authors.lastname: Remoue
mesh_terms: D000330:Aedes / Q000276:immunology*; D000818:Animals; D005260:Female; D006801:Humans; D019476:Insect Proteins / Q000032:analysis* / Q000276:immunology; D012471:Salivary Proteins and Peptides / Q000032:analysis* / Q000276:immunology
chemical_list: D019476:Insect Proteins; D012471:Salivary Proteins and Peptides
keywords: Ae. albopictus; biomarker; exposure; immunogenic; saliva