title: Ventilator-induced lung injury: minimizing its impact in patients with or at risk for ARDS.
abstract: Ventilator-induced lung injury (VILI) results from injury to the blood-gas barrier caused by mechanical ventilation. The determinants of VILI are more complex than originally thought, and include the nature, duration, and intensity of the exposure, as well the pattern of initial insult to the lung. Lung-protective mechanical ventilation founded on these basic principles resulted in improved hospital and long-term mortality. The purpose of this review is to provide a comprehensive assessment of the pathogenesis of VILI and its determinants. We also discuss the best preventive approach in patients with or at risk for ARDS and critically appraise the most recent evidence, expert opinion, and implementation of the acquired knowledge to the bedside.
authors.affiliation: Division of Pulmonary and Critical Care, Multidisciplinary Epidemiology and Translational Research in Intensive Care (METRIC), Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Biehl
authors.forename: Markos G
authors.initials: MG
authors.lastname: Kashiouris
authors.forename: Ognjen
authors.initials: O
authors.lastname: Gajic
mesh_terms: D006801:Humans; D011175:Positive-Pressure Respiration / Q000009:adverse effects* / Q000379:methods; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D055397:Ventilator-Induced Lung Injury / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*
keywords: ARDS; VILI; mechanical ventilation; prevention; tidal volume; ventilator-induced lung injury