title: [Tuberculosis of the breast].
abstract: We report a case of granulomatous mastitis caused by Mycobacterium tuberculosis in an immunocompetent woman with chronic inflammatory lesions of the breast. It was diagnosed by detection of mycobacteria DNA using polymerase chain reaction technique targeting IS6110 insertion element of M. tuberculosis complex in a paraffin-embedded histological specimen. The primary breast tuberculosis is rare, even in countries where the incidence and prevalence of pulmonary and extra pulmonary tuberculosis are high. It should be suspected in female patients with chronic granulomatous mastitis with no apparent cause. The cornerstone of treatment is antituberculous chemotherapy, and surgery is rarely required.
authors.affiliation: División de Apoyo Especializada en Infectología, Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C., Colombia. scuervo@cancer.gov.co
authors.forename: Sonia Isabel
authors.initials: SI
authors.lastname: Cuervo
authors.forename: Diego Andrés
authors.initials: DA
authors.lastname: Bonilla
authors.forename: Martha Isabel
authors.initials: MI
authors.lastname: Murcia
authors.forename: Johana
authors.initials: J
authors.lastname: Hernández
authors.forename: Julio César
authors.initials: JC
authors.lastname: Gómez
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D001706:Biopsy; D001943:Breast Neoplasms / Q000175:diagnosis; D004251:DNA Transposable Elements / Q000235:genetics; D004269:DNA, Bacterial / Q000032:analysis; D003881:Dermatomycoses / Q000175:diagnosis; D003937:Diagnosis, Differential; D004977:Ethambutol / Q000627:therapeutic use; D005188:False Negative Reactions; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008413:Mastitis / Q000175:diagnosis* / Q000473:pathology; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000302:isolation & purification; D011718:Pyrazinamide / Q000627:therapeutic use; D012293:Rifampin / Q000627:therapeutic use; D017192:Skin Diseases, Bacterial / Q000175:diagnosis; D014375:Tuberculoma / Q000175:diagnosis* / Q000473:pathology; D014382:Tuberculosis, Cutaneous / Q000175:diagnosis* / Q000473:pathology; D015431:Weight Loss
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D011718:Pyrazinamide; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin