title: Antioxidant and anti-inflammatory effects of quercetin in functional and morphological alterations in streptozotocin-induced diabetic rats.
abstract: The aim of this study was to investigate functional and morphological alterations caused by oxidative stress in streptozotocin (STZ)-induced diabetic rats and to evaluate the antioxidant effect of quercetin (QUE) in this disease. One hundred and thirty male Wistar rats, it were randomly distributed in 10 different experimental groups, with ten animals per group: Control Saline (CS), Control Ethanol (CE), Control QUE 5mg/kg (CQ5), Control QUE 25mg/kg (CQ25), Control QUE 50mg/kg (CQ50), Diabetic Saline (DS), Diabetic Ethanol (DE), Diabetic QUE 5mg/kg (DQ5), Diabetic QUE25 mg/kg (DQ25), Diabetic QUE 50mg/kg (DQ50). Therefore, hyperglycemia is directly involved in oxidative stress production, as well as in functional and morphological alterations caused by the excess of free radicals. QUE, specially at the dosage of 50mg/kg, can act as an antioxidant and anti-inflammatory agent, becoming a promising adjuvant in the treatment of diabetes mellitus.
authors.affiliation: Laboratório de Análises Clínicas Veterinária - LACVet, Universidade Federal de Santa Maria, Av. Roraima no 1000, Cidade Universitária, Bairro Camobi, 97105-900 Santa Maria, RS, Brazil. roberto.marinho@uol.com.br
authors.forename: R M
authors.initials: RM
authors.lastname: Maciel
authors.forename: M M
authors.initials: MM
authors.lastname: Costa
authors.forename: D B
authors.initials: DB
authors.lastname: Martins
authors.forename: R T
authors.initials: RT
authors.lastname: França
authors.forename: R
authors.initials: R
authors.lastname: Schmatz
authors.forename: D L
authors.initials: DL
authors.lastname: Graça
authors.forename: M M M F
authors.initials: MM
authors.lastname: Duarte
authors.forename: C C
authors.initials: CC
authors.lastname: Danesi
authors.forename: C M
authors.initials: CM
authors.lastname: Mazzanti
authors.forename: M R C
authors.initials: MR
authors.lastname: Schetinger
authors.forename: F C
authors.initials: FC
authors.lastname: Paim
authors.forename: H E
authors.initials: HE
authors.lastname: Palma
authors.forename: F H
authors.initials: FH
authors.lastname: Abdala
authors.forename: N
authors.initials: N
authors.lastname: Stefanello
authors.forename: C K
authors.initials: CK
authors.lastname: Zimpel
authors.forename: D V
authors.initials: DV
authors.lastname: Felin
authors.forename: S T A
authors.initials: ST
authors.lastname: Lopes
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000235:genetics / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D011794:Quercetin; D002374:Catalase; D013482:Superoxide Dismutase
keywords: Diabetes mellitus; Hepatic enzymes; Oxidative stress; Proteins electrophoresis