title: Lose the battle to win the war: bacterial strategies for evading host inflammasome activation.
abstract: The inflammasome is composed of nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins, and leads to caspase-1 activation and subsequent secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and interleukin-18 (IL-18). After certain pathogenic bacteria infect host cells, such as macrophages, NLR-mediated inflammasome activation is triggered to form part of the host defenses against the invading pathogens. However, recent evidence has shown that bacteria have strategies for evading inflammasome activation in host cells. In this review, we focus on NLR-mediated inflammasome activation and bacterial evasion of the inflammasome as part of the battle between the host defenses and pathogens.
authors.affiliation: Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903-0125, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Higa
authors.forename: Claudia
authors.initials: C
authors.lastname: Toma
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Nohara
authors.forename: Noboru
authors.initials: N
authors.lastname: Nakasone
authors.forename: Giichi
authors.initials: G
authors.lastname: Takaesu
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology* / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D058847:Inflammasomes / Q000276:immunology*; D008954:Models, Biological
chemical_list: D058847:Inflammasomes