title: A pilot study of muscle plasma protein changes after exercise.
abstract: BACKGROUND
  Creatine kinase (CK) and myoglobin (Mb) do not possess all good qualities as biomarkers of skeletal muscle damage. We investigated the utility of troponin I (TnI) and telethonin (Tcap) as markers and examined their temporal profiles after skeletal muscle damage.
  
  
  METHODS
  Plasma profiles were measured before and after exercise in 3 groups: subjects affected by either Becker muscular dystrophy or McArdle disease, and healthy subjects.
  
  
  RESULTS
  Mb and TnI appeared early in the blood, and the increase of TnI was only observed in patients with muscle disease. The CK increase was more delayed in plasma. Tcap was not detectable at any time.
  
  
  CONCLUSIONS
  Our results suggest that TnI is a marker of more severe damage signifying sarcomeric damage, and it could therefore be an important supplement to CK and Mb in clinical practice. Tcap is not useful as a marker for skeletal muscle damage.
authors.affiliation: Neuromuscular Research Unit 3342, Department of Neurology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
authors.forename: Julia R
authors.initials: JR
authors.lastname: Dahlqvist
authors.forename: Line G
authors.initials: LG
authors.lastname: Voss
authors.forename: Thomas
authors.initials: T
authors.lastname: Lauridsen
authors.forename: Thomas O
authors.initials: TO
authors.lastname: Krag
authors.forename: John
authors.initials: J
authors.lastname: Vissing
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D064211:Connectin / Q000097:blood*; D003402:Creatine Kinase / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005260:Female; D006003:Glycogen / Q000378:metabolism; D006012:Glycogen Storage Disease Type V / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000378:metabolism / Q000473:pathology; D018482:Muscle, Skeletal / Q000378:metabolism / Q000503:physiopathology*; D020388:Muscular Dystrophy, Duchenne / Q000097:blood / Q000503:physiopathology*; D010865:Pilot Projects; D012518:Sarcomeres / Q000378:metabolism / Q000473:pathology; D019210:Troponin I / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D064211:Connectin; C577292:TCAP protein, human; D019210:Troponin I; D006003:Glycogen; D003402:Creatine Kinase
keywords: creatine kinase; exercise-induced muscle damage; myoglobin; skeletal troponin I; telethonin