title: Effect of hypoxia on glucose metabolism in nondiabetic patients with obstructive sleep apnea syndrome.
abstract: OBJECTIVE
  Obstructive sleep apnea syndrome (OSAS) may promote hyperglycemia and insulin resistance. Our aim is to investigate the effect of OSAS on the fasting plasma glucose, glycosylated hemoglobin (HbA1c), and C reactive protein (CRP) in nondiabetic patients.
  
  
  METHODS
  Blood parameters of consecutive 90 non diabetic patients whom polysomnografic evaluations were done in our sleep laboratory was evaluated. Among these 61 patients with normal fasting blood glucose were classified due to their apne-hipopnea index (AHI) as mild (n=16, 26.2%), moderate (n=18, 29.5%) and severe (n=27, 44.2%) OSAS. The fasting plasma glucose, HbA1c and CRP were measured.
  
  
  RESULTS
  Mean age of the patients was 47.7±11.2 years, 72% male. HbA1c, fasting glucose levels show positive correlation with BMI (r=.503, P=.00; r=.258, P=.045). No relation of HbA1c to apnea index nor AHI was detected while positive corelation of fasting glucose and CRP was detected (r=.262, P=.042; r=.258, P=.045). HbA1c, fasting glucose and CRP levels show negative correlation with minimum SpO2 levels (by order of r=-.302, P=.018; r=-.368, P=.004; r=-.365, P=.004). HbA1c, fasting glucose levels and CRP levels show positive correlation with mean desaturation index (time duration in which SpO2<90% by pulse oxymeter) (r=.263, P=.041; r=.311, P=.015; r=.283, P=.027).
  
  
  CONCLUSIONS
  Although no relation in between increased HbA1c or glucose levels and severity of OSAS was detected in nondiabetic OSAS patients, the correlation with the night hypoxia was detected. This could also show the effect of night time hypoxia on glucose metabolism in OSAS patients.
authors.affiliation: Chest Disease Clinic, Yedikule Chest Disease and Thorax Surgery Education and Research Hospital, Estambul, Turquía. sinemtimur@yahoo.com
authors.forename: Sinem Nedime
authors.initials: SN
authors.lastname: Sökücü
authors.forename: Levent
authors.initials: L
authors.lastname: Karasulu
authors.forename: Levent
authors.initials: L
authors.lastname: Dalar
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozdemir
authors.forename: Ekrem Cengiz
authors.initials: EC
authors.lastname: Seyhan
authors.forename: Senay
authors.initials: S
authors.lastname: Aydin
authors.forename: Sedat
authors.initials: S
authors.lastname: Altin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D005215:Fasting / Q000097:blood; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology*; D000860:Hypoxia / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D002097:C-Reactive Protein; D005947:Glucose; D006442:Glycated Hemoglobin; D010100:Oxygen
keywords: Apnea del sueño; Glycosylated hemoglobin; Hemoglobina glucosilada; Hipoxia; Hypoxia; Sleep apnea