title: Assembly of free-standing polypeptide films via the synergistic combination of hyperbranched macroinitiators, the grafting-from approach, and cross-chain termination.
abstract: Cross-linked polypeptide-based films are fabricated via a novel and robust method employing surface-initiated ring opening polymerization of α-amino acid N-carboxyanhydrides (NCA-ROP). The judicious combination of amine-based hyperbranched macroinitiators and benzyl ester-protected NCA derivatives promotes network formation by cross-chain terminations, which allows the formation of stable cross-linked peptide-based capsules in a one-pot system.
authors.affiliation: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, VIC 3010, Australia.
authors.forename: Steven Harris
authors.initials: SH
authors.lastname: Wibowo
authors.forename: Edgar H H
authors.initials: EH
authors.lastname: Wong
authors.forename: Adrian
authors.initials: A
authors.lastname: Sulistio
authors.forename: Stefanie N
authors.initials: SN
authors.lastname: Guntari
authors.forename: Anton
authors.initials: A
authors.lastname: Blencowe
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
authors.forename: Greg G
authors.initials: GG
authors.lastname: Qiao
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D046911:Macromolecular Substances / Q000737:chemistry; D008958:Models, Molecular; D010316:Particle Size; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D058105:Polymerization; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000596:Amino Acids; D003432:Cross-Linking Reagents; D046911:Macromolecular Substances; D010455:Peptides; D012822:Silicon Dioxide
keywords: N-carboxyanhydrides; cross-linked capsules; polypeptides; ring-opening polymerization; surface-initiated polymerization