title: Acute mucosal reactions in patients with head and neck cancer. Three patterns of mucositis observed during radiotherapy.
abstract: OBJECTIVE
  To investigate the individual pattern of acute mucosal radiation reactions (AMRR) in patients with head and neck cancer who were treated with radiotherapy alone. Reactions were evaluated daily on an individual basis according to the Dische scoring system.
  
  
  METHODS
  Treatment of 87 head and neck cancer patients comprised either conventional fractionation- (CF; n = 33), accelerated fractionation (AF; n = 33), hyperfractionated- (HPEFX; n = 12) or hypofractionated (HPOFX; n = 9) radiotherapy with radical intent. Daily evaluation of AMRR progression was performed prospectively using a modified, morphologically functional Dische scoring system. The daily sums of the score parameters were subsequently used to construct an individual AMRR course curve for each patient.
  
  
  RESULTS
  A latency period ranging from 3 to 14 days between the start of radiotherapy and the occurrence of the first AMRR symptom was observed in all patients. Based on the three different shapes of AMRR course curve observed during radiotherapy, three types of AMRR course can be described: (1) a continual increase in AMRR intensity until the completion of radiotherapy; (2) the incidence of a plateau phase following the increase in AMRR (increase-plateau course) and (3) decreasing AMRR intensity with a healing phase. A continual increase in AMRR intensity was observed in about 25 % of CF and AF patients and in more than 50 % of HPOFX treatments. This type of reaction was not observed in the HPEFX group. The increase-plateau course was noted in the majority of AF and CF patients; in almost half of those treated with HPOFX and in all HPEFX patients. A decreasing AMRR intensity course was observed in 23 % of all patients, although not observed at all in the HPEFX and HPOFX fractionation groups.
  
  
  CONCLUSIONS
  The course of AMRR during radiotherapy can differ between individual patients. After the initial increase in AMRR intensity, a stabilization of the reaction--visible as a plateau phase on the course curve--is observed in the majority of patients. A proportion of the irradiated patients experience a continual increase in AMRR intensity up until the end of radiotherapy. A further group of patients exists in whom signs of AMRR healing are observed during the final stages of radiotherapy.
authors.affiliation: Ist Department of Radiation Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland, Ul. Wybrzeże Armii Krajowej 15, 44-101, Gliwice, Poland. awygoda@poczta.onet.pl
authors.forename: A
authors.initials: A
authors.lastname: Wygoda
authors.forename: T
authors.initials: T
authors.lastname: Rutkowski
authors.forename: M
authors.initials: M
authors.lastname: Hutnik
authors.forename: K
authors.initials: K
authors.lastname: Składowski
authors.forename: M
authors.initials: M
authors.lastname: Goleń
authors.forename: B
authors.initials: B
authors.lastname: Pilecki
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007820:Laryngeal Mucosa / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000528:radiation effects; D052016:Mucositis / Q000175:diagnosis*; D009367:Neoplasm Staging; D010039:Otorhinolaryngologic Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D010614:Pharynx / Q000528:radiation effects; D011446:Prospective Studies; D011832:Radiation Injuries / Q000175:diagnosis*