title: The effect of glass ionomer and adhesive cements on substance P expression in human dental pulp.
abstract: OBJECTIVE
  The purpose of this study was to quantify the effect of glass ionomer and adhesive cements on SP expression in healthy human dental pulp.
  
  
  METHODS
  Forty pulp samples were obtained from healthy premolars where extraction was indicated for orthodontic reasons. In thirty of these premolars a Class V cavity preparation was performed and teeth were equally divided in three groups: Experimental Group I: Glass Ionomer cement was placed in the cavity. Experimental Group II: Adhesive Cement was placed in the cavity. Positive control group: Class V cavities only. The remaining ten healthy premolars where extracted without treatment and served as a negative control group. All pulp samples were processed and SP was measured by radioimmunoassay.
  
  
  RESULTS
  Greater SP expression was found in the adhesive cement group, followed by the glass ionomer and the positive control groups. The lower SP values were for the negative control group. ANOVA showed statistically significant differences between groups (p<0.0001). Tukey HSD post hoc tests showed statistically significant differences in SP expression between negative control group and the 3 other groups (p<0.01). Differences between the cavity-only group and the two experimental groups were also statistically significant (p<0.05 and p<0.01 respectively). There is also a statistically significant difference between the two experimental groups (p<0.01).
  
  
  CONCLUSIONS
  These findings suggest that adhesive cements provoke a greater SP expression when compared with glass ionomer.
authors.affiliation: School of Dentistry, Pontificia Universidad Javeriana, Cra 7 No. 40-62 Building 26, Bogotá, Colombia, javiercaviedes@gmail.com.
authors.forename: Javier
authors.initials: J
authors.lastname: Caviedes-Bucheli
authors.forename: German
authors.initials: G
authors.lastname: Ariza-Garcia
authors.forename: Patricia
authors.initials: P
authors.lastname: Camelo
authors.forename: Monica
authors.initials: M
authors.lastname: Mejia
authors.forename: Karyn
authors.initials: K
authors.lastname: Ojeda
authors.forename: Maria-Mercedes
authors.initials: MM
authors.lastname: Azuero-Holguin
authors.forename: Dunia
authors.initials: D
authors.lastname: Abad-Coronel
authors.forename: Hugo-Roberto
authors.initials: HR
authors.lastname: Munoz
mesh_terms: D000180:Acrylic Resins / Q000494:pharmacology*; D003782:Dental Pulp / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D019279:Resin Cements / Q000494:pharmacology*; D012822:Silicon Dioxide / Q000494:pharmacology*; D013373:Substance P / Q000096:biosynthesis* / Q000187:drug effects
chemical_list: D000180:Acrylic Resins; D019279:Resin Cements; C015897:glass ionomer; C095998:Adhesive cement; D013373:Substance P; D012822:Silicon Dioxide