title: Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population.
abstract: OBJECTIVE
  Polymorphism of the interleukin-23 receptor gene corresponds with susceptibility to several immune-related diseases. For the terminal differentiation of IL-17-producing effector T-helper cells in vivo, the interleukin-23 receptor gene is of vital importance. As shown recently, Th17 cells probably have a great influence on the pathogenesis of allergic airway diseases. Our intention was to establish an association between polymorphisms in the IL-23R gene and allergic rhinitis (AR) in the Chinese Han population.
  
  
  METHODS
  We included 358 AR patients and 407 control Chinese subjects in a case-control comparison. The study involved obtaining blood samples for DNA extraction genotyping and determination of 4 selected single-nucleotide polymorphisms in IL-23R by performing PCR restriction fragment length polymorphism analysis (PCR-RFLP).
  
  
  RESULTS
  A substantially growing prevalence of the homozygous rs7517847 GG genotype and G allele appeared in the AR patients unlike that observed in the control individuals (P<0.001). In addition, substantially high frequencies of the GGCA and GGCG haplotypes were observed in the AR patients, unlike that observed in the control individuals (P<0.05). The results suggest that the AGTG haplotype may provide protection against AR (P<0.001).
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in IL-23R and AR in the Chinese Han population. A strong association between rs7517847 in a SNP of IL-23R, and AR was identified.
authors.affiliation: Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, People’s Republic of China.
authors.forename: Di
authors.initials: D
authors.lastname: Hu
authors.forename: Guohua
authors.initials: G
authors.lastname: Hu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.forename: Houyong
authors.initials: H
authors.lastname: Kang
authors.forename: Suling
authors.initials: S
authors.lastname: Hong
mesh_terms: D000328:Adult; D044466:Asian People; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics*
chemical_list: D018123:Receptors, Interleukin