title: Two new withanolides from the halophyte Datura stramonium L.
abstract: Eight steroids, including five withanolides (1-5) and three other ergostane-type steroids (6-8), were isolated from the aerial parts of the halophyte Datura stramonium L., which were collected from the Yellow River Delta in China. Their structures were elucidated on the basis of extensive spectroscopic methods, especially 1D and 2D NMR techniques. Compounds 1 and 2 were new compounds and characterised as (22R)-27-hydroxy-7α-methoxy-1-oxowitha-3,5,24-trienolide and its 27-O-β-d-glucopyranoside. Compound 3 was a new natural product and identified as (22R)-27-hydroxy-1-oxowitha-2,5,24-trienolide and isolated from nature for the first time.
authors.affiliation: a Key Laboratory of Coastal Biology and Biological Resources Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences , Yantai , 264003 , P.R. China.
authors.forename: Sheng-Tao
authors.initials: ST
authors.lastname: Fang
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.forename: Na-Na
authors.initials: NN
authors.lastname: Kong
authors.forename: Su-Jing
authors.initials: SJ
authors.lastname: Liu
authors.forename: Chuan-Hai
authors.initials: CH
authors.lastname: Xia
mesh_terms: D013286:Datura stramonium / Q000737:chemistry*; D015394:Molecular Structure; D055051:Salt-Tolerant Plants / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry*; D054358:Withanolides / Q000737:chemistry*
chemical_list: D013256:Steroids; D054358:Withanolides