title: A new occlusion device: application of the ArtVentive endoluminal occlusion system (EOS)--first in human clinical trial.
abstract: OBJECTIVE
  The purpose of this study was to determine the safety and efficacy of a new endoluminal occlusion device, ArtVentive endoluminal occlusion system (EOS), to occlude the spermatic vein in symptomatic males with varicoceles.
  
  
  METHODS
  The ArtVentive EOS device has been developed for percutaneous, peripheral occlusion of the peripheral arterial and venous vasculature. The system is comprised of an implantable occlusion device and a delivery catheter. At present, there are two device sizes: (a) size 1 for target vessels ranging between 3.5 and 5.5 mm in diameter, and (b) size 2 for target vessels 5.5-8.5 mm in diameter. The treatment group included six adult males, ages 22-34 years. Nine target vessels were occluded. A total of 20 devices were implanted in six subjects.
  
  
  RESULTS
  The acute occlusion rate at the end of the procedure was 100 % occurring in nine of nine vessels. The spermatic veins of all patients remained occluded on venography at 30 days follow-up. Pain scores related to varicoceles decreased in five of six patients.
  
  
  CONCLUSIONS
  Although we recognize this study is limited, initial experience indicates that the ArtVentive EOS is a safe and effective new device for occlusion of vessels (varicoceles). The device has potential applications in other clinical conditions requiring occlusion of veins or arteries.
authors.affiliation: Division of Vascular and Interventional Radiology, The George Washington University Medical Center, 900 23rd St, NW, Suite G2092, Room 119, Washington, DC, 20037, USA, avenbrux@mfa.gwu.edu.
authors.forename: Anthony C
authors.initials: AC
authors.lastname: Venbrux
authors.forename: Leon
authors.initials: L
authors.lastname: Rudakov
authors.forename: Andre
authors.initials: A
authors.lastname: Plass
authors.forename: Maximilian Y
authors.initials: MY
authors.lastname: Emmert
authors.forename: Adrian
authors.initials: A
authors.lastname: Ebner
mesh_terms: D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010690:Phlebography; D019736:Prostheses and Implants; D011474:Prosthesis Design; D015641:Radiography, Interventional; D013085:Spermatic Cord / Q000098:blood supply*; D016896:Treatment Outcome; D014646:Varicocele / Q000628:therapy*; D014680:Veins
chemical_list: D003287:Contrast Media