title: Correlation of late gadolinium enhancement MRI and quantitative T2 measurement in cardiac sarcoidosis.
abstract: OBJECTIVE
  To investigate the potentially improved detection and quantification of cardiac involvement using novel late-gadolinium-enhancement (LGE) cardiac magnetic resonance imaging (MRI) and quantitative T2 measurement to achieve better myocardial tissue characterization in systemic sarcoidosis.
  
  
  METHODS
  Twenty-eight patients with systemic sarcoidosis underwent a cardiac magnetic resonance imaging (CMR) study on a 1.5T system. Precontrast CMR included left ventricular (LV) and right ventricular (RV) function and quantitative T2 measurement. Postcontrast LGE-MRI included inversion-recovery fast-gradient-echo (IR-FGRE) and multicontrast late-enhancement imaging (MCLE).
  
  
  RESULTS
  LV functional parameters were normal in all patients (LVEF=61.2±8.5%) including with cardiac involvement (LVEF=59.4±12.1%) and without (LVEF=61.7±7.5%) while the average RV function was comparatively decreased (RVEF=48.0±6.6%, P<0.0001). 21.4% of patients had cardiac involvement showing patchy or multiple focal hyperenhancement patterns in LV free wall, papillary muscles (PM), or interventricular septum. In two cases with PM involvement, the PM abnormal LGE foci were only observed on MCLE. For precontrast T2 measurements, a significantly decreased T2 measurement was observed in regions demonstrating LGE, compared to the LGE-negative group (focal LGE-positive regions vs. negative: 40.0±2.4 msec vs. 53.0±2.6 msec, P<0.0001).
  
  
  CONCLUSIONS
  LGE-MRI can identify cardiac involvement in systemic sarcoidosis. MCLE might be more sensitive at detecting subtle myocardial lesion. The decreased T2 observed in cardiac sarcoid may reflect its inactive phase, thus might provide a noninvasive method for monitoring disease activity or therapy.
authors.affiliation: Imaging Research and Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Yuesong
authors.initials: Y
authors.lastname: Yang
authors.forename: Katherine
authors.initials: K
authors.lastname: Safka
authors.forename: John J
authors.initials: JJ
authors.lastname: Graham
authors.forename: Idan
authors.initials: I
authors.lastname: Roifman
authors.forename: Mohammad I
authors.initials: MI
authors.lastname: Zia
authors.forename: Graham A
authors.initials: GA
authors.lastname: Wright
authors.forename: Meyer
authors.initials: M
authors.lastname: Balter
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Dick
authors.forename: Kim A
authors.initials: KA
authors.lastname: Connelly
mesh_terms: D000328:Adult; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D019786:Gadolinium DTPA; D006334:Heart Function Tests; D006801:Humans; D007089:Image Enhancement; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012507:Sarcoidosis / Q000175:diagnosis* / Q000473:pathology; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D019786:Gadolinium DTPA
keywords: T2 measurement; cardiac sarcoidosis; late gadolinium enhancement MRI