title: Role of placental nutrient sensing in developmental programming.
abstract: Altered maternal nutrition and metabolism, restricted utero-placental blood flow, and other perturbations in the maternal compartment may disturb critical periods of fetal development resulting in increased susceptibility to develop disease in childhood and adult life. In response to these perturbations, changes in placental structure and function occur, which influence the supply of nutrients, oxygen, and methyl donors and alter the secretion of hormones and other signaling molecules into the fetal circulation. Thus, the placenta plays a critical role in modulating maternal-fetal resource allocation, thereby affecting fetal growth and the long-term health of the offspring.
authors.affiliation: Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA. jansson@uthscsa.edu
authors.forename: Thomas
authors.initials: T
authors.lastname: Jansson
authors.forename: Theresa L
authors.initials: TL
authors.lastname: Powell
mesh_terms: D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2 / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000196:embryology; D003924:Diabetes Mellitus, Type 2 / Q000196:embryology; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D048070:Fetal Nutrition Disorders / Q000378:metabolism*; D006801:Humans; D039382:Maternal Nutritional Physiological Phenomena; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D010920:Placenta / Q000473:pathology / Q000503:physiopathology*; D021041:Placental Circulation; D010927:Placental Insufficiency / Q000378:metabolism*; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena; D015398:Signal Transduction; D014327:Trophoblasts / Q000378:metabolism
chemical_list: D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2