title: Fluoride dentifrice containing xylitol: in vitro root caries formation.
abstract: OBJECTIVE
  To evaluate the effects of experimental xylitol dentifrices with and without fluoride on in vitro root caries formation.
  
  
  METHODS
  Root surfaces from caries-free human permanent teeth (n = 10) underwent debridement and a fluoride-free prophylaxis. The tooth roots were sectioned into quarters, and acid-resistant varnish was placed with two sound root surface windows exposed on each tooth quarter. Each quarter from a single tooth was assigned to a treatment group: (1) No treatment control; (2) Aquafresh Advanced (0.15% F = 1,150 ppm F); (3) Experimental xylitol dentifrice without fluoride (0.45% xylitol); and (4) Diamynt fluoride dentifrice with xylitol (0.83% sodium monofluorophosphate = 1,100 ppm F and 0.20% xylitol). Tooth root quarters were treated with fresh dentifrice twice daily (3 minutes) followed by fresh synthetic saliva rinsing over a 7-day period. Controls were exposed twice daily to fresh synthetic saliva rinsing daily over a 7-day period. In vitro root caries were created using an acidified gel (pH 4.25, 21 days). Longitudinal sections (three sections/tooth quarter, 60/group) were evaluated for mean lesion depths (water inhibition, polarized light, ANOVA, DMR).
  
  
  RESULTS
  Mean lesion depths were 359 +/- 37 microm for the control Group; 280 +/- 28 microm for Aquafresh Advanced; 342 +/- 41 microm for the experimental xylitol dentifrice without fluoride; and 261 +/- 34 microm for Diamynt. Aquafresh Advanced and Diamynt had mean lesion depths significantly less than those for the no treatment control and the experimental xylitol without fluoride dentifrice (P< 0.05). There were minimal non-significant differences in mean lesion depths between Aquafresh Advanced and Diamynt (P > 0.05).
authors.affiliation: Bioscience Research Center, College of Dentistry, University of Tennessee Health Science Center, 875 Union Avenue, Memphis, TN 38163, USA. fgarciagodoy@gmail.com
authors.forename: Franklin
authors.initials: F
authors.lastname: García-Godoy
authors.forename: Lisa Marie
authors.initials: LM
authors.lastname: Kao
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Flaitz
authors.forename: John
authors.initials: J
authors.lastname: Hicks
mesh_terms: D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003802:Dentifrices / Q000008:administration & dosage / Q000627:therapeutic use*; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000009:adverse effects; D008422:Materials Testing; D008859:Microscopy, Polarization; D010710:Phosphates / Q000008:administration & dosage / Q000627:therapeutic use; D017213:Root Caries / Q000209:etiology* / Q000517:prevention & control; D012464:Saliva, Artificial / Q000737:chemistry; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use; D017001:Tooth Demineralization / Q000209:etiology; D014092:Tooth Root / Q000187:drug effects / Q000648:ultrastructure; D014993:Xylitol / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D002327:Cariostatic Agents; D003802:Dentifrices; D010710:Phosphates; D012464:Saliva, Artificial; C012980:fluorophosphate; D019344:Lactic Acid; D012969:Sodium Fluoride; D005459:Fluorides; D014993:Xylitol