title: Can diabetes I and early blindness be prevented using a tylenol combination which inhibits oxidative and nitrosative stress?
abstract: Since oxidative/nitrosative stress cause diabetes, can we prevent this chemistry generating the disease? Streptozotocin causes diabetes by entering the pancreatic beta cell generating excessive nitric oxide which reacts with oxygen creating a toxin possibly peroxynitrite, dinitrogen trioxide, dinitrogen tetraoxide and so forth. The toxic compounds damage the DNA causing beta cell death. This prevents insulin synthesis, storage and release. By using antioxidant substances that destroy the nitric-oxide-based toxins (e.g., carboxy-PTIO (oxidizes nitric oxide), polyphenolic-quercetin and monophenolic acetaminophen (Tylenol)) which are oxidation and nitration targets can the diabetes I causing toxins in animals be destroyed? Will this tri-drug combination completely prevent the deleterious effects of diabetes namely poor blood glucose control and blindness from cataracts for the entire length of the experiment (one year). These disease reversal experiments were accomplished in rats where the streptozotocin-diabetic effects were completely thwarted. In vitro experiments were accomplished to provide the scientific basis for the experimental results in animals.
authors.affiliation: Department of Biochemistry and Molecular Pharmacology, Robert C. Byrd Medical Center, West Virginia University Morgantown, WV 26506, USA.
authors.forename: Knox
authors.initials: K
authors.lastname: Van Dyke
authors.forename: Erica
authors.initials: E
authors.lastname: Ghareeb
authors.forename: Robert
authors.initials: R
authors.lastname: Hoeldtke
authors.forename: Mark
authors.initials: M
authors.lastname: Van Dyke
authors.forename: Chris
authors.initials: C
authors.lastname: Van Dyke
authors.forename: David
authors.initials: D
authors.lastname: Van Thiel