title: Hematoma volume measurement in gradient echo MRI using quantitative susceptibility mapping.
abstract: OBJECTIVE
  A novel quantitative susceptibility mapping (QSM) processing technology has been developed to map tissue susceptibility property without blooming artifacts. We hypothesize that hematoma volume measurement on QSM is independent of imaging parameters, eliminating its echo time dependence on gradient echo MRI.
  
  
  METHODS
  Gradient echo MRI of 16 patients with intracerebral hemorrhage was processed with susceptibility-weighted imaging, R2* (=1/T2*) mapping, and QSM at various echo times. Hematoma volumes were measured from these images.
  
  
  RESULTS
  Linear regression of hematoma volume versus echo time showed substantial slopes for gradient echo magnitude (0.45±0.31 L/s), susceptibility-weighted imaging (0.52±0.46), and R2* (0.39±0.30) but nearly zero slope for QSM (0.01±0.05). At echo time=20 ms, hematoma volume on QSM was 0.80× that on gradient echo magnitude image (R2=0.99).
  
  
  CONCLUSIONS
  QSM can provide reliable measurement of hematoma volume, which can be performed rapidly and accurately using a semiautomated segmentation tool.
authors.affiliation: Department of Radiology, Weill Medical College of Cornell University, New York, NY 10022, USA.
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Lou
authors.forename: Tian
authors.initials: T
authors.lastname: Liu
authors.forename: Deqi
authors.initials: D
authors.lastname: Cui
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000208:Acute Disease; D000368:Aged; D002543:Cerebral Hemorrhage / Q000473:pathology*; D004198:Disease Susceptibility / Q000473:pathology; D005260:Female; D006406:Hematoma / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods / Q000592:standards; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods / Q000592:standards; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D008297:Male; D008875:Middle Aged
keywords: gradient echo; hematoma volume; intracerebral hemorrhage; magnetic resonance imaging; quantitative susceptibility mapping