title: Short-term cardiovascular physical programme ameliorates arterial stiffness and decreases oxidative stress in women with metabolic syndrome.
abstract: OBJECTIVE
  To evaluate the impact of a short-term cardiovascular physical programme on the metabolic, anthropometric and oxidative stress parameters of women with metabolic syndrome.
  
  
  METHODS
  Thirty sedentary female patients, age range 30-60 years, were invited to participate in a 6-week cardiovascular physical programme. The training consisted of 60-min sessions of aerobic and strength exercises performed 3 times a week; a total of 18 sessions. Anthropometric data, functional exercise capacity, general biochemical profile, serum lipid peroxidation, superoxide dismutase and catalase activity in erythrocytes were evaluated according to standardized protocols. Peripheral vascular function was assessed using applanation tonometry. All assessments were performed before and after the training programme.
  
  
  RESULTS
  The physical programme proved effective in improving the distance covered in the 6-min walk test and in reducing arterial pressure levels, pulse pressure and the Augmentation Index, without modifying heart rate. The plasma thiobarbituric acid reactive substances levels, indicators of oxidative stress, were significantly decreased after the programme. Superoxide dismutase activity was increased in erythrocyte lysates, with no significant change in catalase activity. Waist circumference was significantly decreased compared with baseline. The distance covered in the 6-min walk test was significantly greater after the short-term cardiovascular training.
  
  
  CONCLUSIONS
  These findings indicate that short-term combined aerobic and strength training may represent an important non-pharmacological approach for treating individuals with metabolic syndrome.
authors.affiliation: Laboratório de Reatividade Cardiovascular, Setor de Fisiologia e Farmacologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil.
authors.forename: Marcos Antonio
authors.initials: MA
authors.lastname: Eleutério-Silva
authors.forename: Lucas José
authors.initials: LJ
authors.lastname: Sá da Fonseca
authors.forename: Elizabeth P P
authors.initials: EP
authors.lastname: Velloso
authors.forename: Glaucevane
authors.initials: G
authors.lastname: da Silva Guedes
authors.forename: Walkyria O
authors.initials: WO
authors.lastname: Sampaio
authors.forename: Weriton Ferreira
authors.initials: WF
authors.lastname: da Silva
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Mota-Gomes
authors.forename: Lucy V
authors.initials: LV
authors.lastname: da Silva Lima
authors.forename: Robson Augusto S
authors.initials: RA
authors.lastname: Santos
authors.forename: Luiza A
authors.initials: LA
authors.lastname: Rabelo
mesh_terms: D000328:Adult; D000886:Anthropometry; D015415:Biomarkers / Q000378:metabolism; D001794:Blood Pressure; D015444:Exercise; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D015227:Lipid Peroxidation; D008365:Manometry; D024821:Metabolic Syndrome / Q000503:physiopathology* / Q000534:rehabilitation*; D008875:Middle Aged; D018384:Oxidative Stress; D055070:Resistance Training; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*; D059289:Vascular Stiffness; D055105:Waist Circumference; D016138:Walking
chemical_list: D015415:Biomarkers; D017392:Thiobarbituric Acid Reactive Substances; D013482:Superoxide Dismutase