title: Bortezomib-induced polyneuropathy.
abstract: BACKGROUND
  Peripheral neuropathy is a frequent side effect of bortezomib chemotherapy. Relatively little is known about the clinical characteristics of this neuropathy, especially with respect to pain. Our aim was to describe the clinical characteristics and course of bortezomib-induced polyneuropathy.
  
  
  METHODS
  This is a retrospective cohort study of 39 patients diagnosed with bortezomib-induced polyneuropathy.
  
  
  RESULTS
  Pain is the most prominent symptom and 14 of 39 patients suffered from severe pain. More than 50% of our patients used analgesics due to moderate or severe pain. We found no correlation between severity of symptoms of bortezomib-induced polyneuropathy and cumulative dose or dose intensity of bortezomib. Nerve conduction studies did not correlate well with symptom severity. Dose reduction or discontinuation of treatment reduced severity in most cases.
  
  
  CONCLUSIONS
  Painful polyneuropathy is a frequent, dose-limiting side effect of bortezomib with a relatively good prognosis. Careful neurological monitoring of symptoms and timely dose adjustment is important.
authors.affiliation: Department of Neurology, HagaZiekenhuis, The Hague, The Netherlands. ajjrampen@hotmail.com
authors.forename: A J J
authors.initials: AJ
authors.lastname: Rampen
authors.forename: J L M
authors.initials: JL
authors.lastname: Jongen
authors.forename: I
authors.initials: I
authors.lastname: van Heuvel
authors.forename: M
authors.initials: M
authors.lastname: Scheltens-de Boer
authors.forename: P
authors.initials: P
authors.lastname: Sonneveld
authors.forename: M J
authors.initials: MJ
authors.lastname: van den Bent
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001897:Boronic Acids / Q000627:therapeutic use; D000069286:Bortezomib; D015331:Cohort Studies; D006801:Humans; D009101:Multiple Myeloma; D011115:Polyneuropathies; D011719:Pyrazines / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib