title: Functional connectivity abnormalities during contextual processing in schizophrenia and in Parkinson's disease.
abstract: Functional connectivity was evaluated in patients with schizophrenia (SC) and in patients with Parkinson's disease (PD) during the performance of a local contextual processing paradigm, to investigate the proposition that functional disconnection is involved with contextual processing deficits in these populations. To this end, we utilized event-related EEG signals, synchronization likelihood and graph theoretical analysis. Local context was defined as the occurrence of a predictive sequence of stimuli before the presentation of a target event. In the SC patients, we observed a decrease in path length (L) in the beta band, for the predictive sequence and for predicted and random targets, compared with controls. These abnormalities were associated with weaker frontal-temporal-parietal connections. In the PD patients we found longer L (theta band) for predicted targets, and higher cluster coefficients for both the predictive sequence (theta band) and predicted targets (alpha and theta bands), compared with controls. Detection of predicted targets was associated with weaker frontal-parietal connections in PD. No group differences were found for randomized standard stimuli in both SC and PD patients. These findings provide evidence of task-specific functional connectivity abnormalities within frontal networks during local contextual processing.
authors.affiliation: Department of Psychology, University of A Coruña, La Coruña, Spain. nfogelson@udc.es
authors.forename: Noa
authors.initials: N
authors.lastname: Fogelson
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Miguel
authors.initials: M
authors.lastname: Fernandez-Del-Olmo
authors.forename: Diego
authors.initials: D
authors.lastname: Santos-Garcia
authors.forename: Avi
authors.initials: A
authors.lastname: Peled
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D058256:Brain Waves; D003344:Cortical Synchronization; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology*; D012559:Schizophrenia / Q000473:pathology / Q000503:physiopathology*
keywords: Context; EEG; Graph theory; Parkinson’s disease; Schizophrenia; Synchronization likelihood