title: A unique case of two primaries: carcinoma breast with carcinoma gallbladder.
abstract: The presence of two primary cancers in a patient is a very rare entity. Carcinoma breast and carcinoma gallbladder are one of the commonest cancers in North Indian women. We report a unique case of carcinoma breast with synchronous primary cancer in gallbladder. A 52-year-old woman presented with a lump in her left breast since 6 months. On examination, the lump was malignant with the involvement of the overlying skin and ipsilateral axillary lymphadenopathy. She also had hepatomegaly with palpable gallbladder lump. On imaging, there was a gallbladder mass infiltrating the adjacent organs. Biopsy of the breast lump revealed infiltrating ductal carcinoma, which was oestrogen, progesterone and HER-2 neu receptor positive. Immunohistochemistry analysis using cytokeratin 7 and 20 on gallbladder and breast mass biopsy specimen revealed the presence of separate primary cancers of gallbladder and breast. The patient received palliative chemotherapy, but died of the disease 5 months after diagnosis.
authors.affiliation: Department of Surgical Oncology, King George Medical University (KGMU), Lucknow, Uttar Pradesh, India. jaipalreddy.pogal@gmail.com
authors.forename: Jaipalreddy
authors.initials: J
authors.lastname: Pogal
authors.forename: Vijay
authors.initials: V
authors.lastname: Kumar
authors.forename: Nuzhat
authors.initials: N
authors.lastname: Husain
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Misra
mesh_terms: D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D014057:Tomography, X-Ray Computed