title: Serial haemostatic monitoring of dogs with multicentric lymphoma.
abstract: Lymphoma is the most common haematopoietic malignancy in dogs and it has been associated with hypercoagulability and subsequent thromboembolism. The objectives of this study were to serially characterize the haemostatic status of dogs with multicentric lymphoma. Thromboelastography, thrombin-antithrombin complex concentration and routine haematology and coagulation panels were measured. Twenty-seven dogs were included in the study and 15 completed the study in remission. At presentation, 81% (22/27) of dogs with multicentric lymphoma had altered haemostatic profiles consistent with hypercoagulability. Laboratory evidence of hypercoagulability did not resolve during treatment or for up to 1 month following attainment of clinical remission. Accelerated rate of clot formation at the time of chemotherapeutic protocol completion was associated with decreased survival time. We concluded that dogs with multicentric lymphoma were frequently hypercoagulable from presentation through 4 weeks after the completion of chemotherapy. Increased angle and shortened K in dogs that have successfully completed their chemotherapeutic protocol may be associated with shorter survival times.
authors.affiliation: Department of Pathology, Microbiology and Immunology, University of California, Davis, CA 95616, USA.
authors.forename: A
authors.initials: A
authors.lastname: Kol
authors.affiliation: Department of Medicine and Epidemiology, University of California, Davis, CA 95616, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Marks
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Skorupski
authors.affiliation: Department of population, health & reproduction, University of California, Davis, CA 95616, USA.
authors.forename: P H
authors.initials: PH
authors.lastname: Kass
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
authors.forename: T
authors.initials: T
authors.lastname: Guerrero
authors.affiliation: Department of Medical Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Gosselin
authors.affiliation: Department of Pathology, Microbiology and Immunology, University of California, Davis, CA 95616, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Borjesson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001344:Autopsy / Q000662:veterinary; D001780:Blood Coagulation Tests / Q000662:veterinary; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000097:blood* / Q000188:drug therapy; D004285:Dogs; D005260:Female; D006487:Hemostasis; D008223:Lymphoma / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D016019:Survival Analysis; D013916:Thrombelastography; D013927:Thrombosis / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*
chemical_list: D000970:Antineoplastic Agents
keywords: canine; coagulation; haemostasis; lymphoma; thromboelastography