title: Experimental chronic wasting disease in wild type VM mice.
abstract: Chronic wasting disease (CWD) is a naturally occurring prion disease in North American deer (Odocoileus species), Rocky mountain elk (Cervus elaphus nelsoni) and moose (Alces alces). The disease was first confirmed in the Republic of Korea in 2001, and subsequent cases were diagnosed in 2004, 2005 and 2010. The experimental host range of CWD includes ferrets, several species of voles, white-footed mice, deer mice and Syrian golden hamsters. In addition, CWD was transmitted to the transgenic mouse over-expressing elk or deer prion protein efficiently, but not to wild type mouse. Here, we report the experimental transmission of elk CWD to conventional VM/Dk mice reaching 100% attack rate after second passage. The CWD-prion-affected wild type mice will be a useful model for future CWD studies.
authors.affiliation: OIE Reference Laboratory for CWD, Animal, Plant and Fisheries Quarantine and Inspection Agency, Ministry for Food, Agriculture, Forestry and Fisheries, Anyang 430-757, Republic of Korea.
authors.forename: Yoon-Hee
authors.initials: YH
authors.lastname: Lee
authors.forename: Hyun-Joo
authors.initials: HJ
authors.lastname: Sohn
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Hyo-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Kyung-Je
authors.initials: KJ
authors.lastname: Park
authors.forename: Won-Yong
authors.initials: WY
authors.lastname: Lee
authors.forename: Eun-Im
authors.initials: EI
authors.lastname: Yun
authors.forename: Dong-Seob
authors.initials: DS
authors.lastname: Tark
authors.forename: Young-Pyo
authors.initials: YP
authors.lastname: Choi
authors.forename: In-Soo
authors.initials: IS
authors.lastname: Cho
authors.forename: Aru
authors.initials: A
authors.lastname: Balachandran
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D051379:Mice; D008815:Mice, Inbred Strains; D056910:Republic of Korea; D013045:Species Specificity; D034081:Wasting Disease, Chronic / Q000503:physiopathology* / Q000635:transmission