title: The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial.
abstract: OBJECTIVE
  The present study aims to investigate the effects of the combined therapy myo-inositol (MI) plus D-chiro-inositol (DCI) or D-chiro-inositol treatment in oocyte quality.
  
  
  METHODS
  Polycystic ovary syndrome (PCOS) women undergoing IVF-ET were treated with myo-inositol combined with D-chiro-inositol in the physiological ratio (1.1 g myo-inositol plus 27.6 mg of D-chiro-inositol; INOFOLIC combi Lo.Li.pharma) or D-chiro-inositol alone (500 mg; Interquim, s.a., Barcelona, Spain) to evaluate the umber of morphological mature oocytes, total International Units (IU) of recombinant FSH administered and the number of grade 1 embryos.
  
  
  RESULTS
  The data clearly showed that only the combined therapy was able to improve oocyte and embryo quality, as well as pregnancy rates, in PCOS women undergoing IVF-ET.
  
  
  CONCLUSIONS
  The present paper further supports the hypothesis that MI plays a crucial role in the ovary in PCOS women. In particular, due to the physiological role played by MI and DCI, the combined therapy should represent a better choice.
authors.affiliation: Department of Psychology, Section of Neuroscience, University of Rome "Sapienza", Via dei Marsi 78, 00185, Rome, Italy.
authors.forename: Sandra
authors.initials: S
authors.lastname: Colazingari
authors.forename: Mariangela
authors.initials: M
authors.lastname: Treglia
authors.forename: Robert
authors.initials: R
authors.lastname: Najjar
authors.forename: Arturo
authors.initials: A
authors.lastname: Bevilacqua
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007294:Inositol / Q000008:administration & dosage / Q000627:therapeutic use*; D009865:Oocytes / Q000187:drug effects* / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D011247:Pregnancy; D013030:Spain; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; D014803:Vitamin B Complex; D007294:Inositol