title: The influence of early diagnosis of endometrioid endometrial cancer on disease stage and survival.
abstract: OBJECTIVE
  To evaluate whether the presence or duration of uterine bleeding is associated with disease stage, and survival of patients with endometrioid endometrial carcinoma (EEC).
  
  
  METHODS
  The records of 220 patients with EEC who underwent surgery were reviewed. The patients were divided into three groups according to the presence and duration of vaginal bleeding at the time of surgery. Group 1, without vaginal bleeding; group 2, vaginal bleeding up to 3 months; group 3, vaginal bleeding exceeding 3 months prior to surgery. Disease stage and survival were between the three groups.
  
  
  RESULTS
  Of the 220 patients, 42 (19%) were asymptomatic; 95 (43%) had symptom duration of up to 3 months and 83 (38%) experienced bleeding for >3 months. There were no significant differences between groups 1, 2 and 3 regarding the proportion of patients with deep invasion in stage I (21, 24, 26%, p = 0.84; respectively), with grade 3 tumors (10, 13, 14%, p = 0.42; respectively) or with advanced stage disease (12, 14, 15%, p = 0.92; respectively). Survival analysis demonstrated a non-significant trend toward better survival in asymptomatic patients and in patients with a shorter duration of symptoms (p = 0.172).
  
  
  CONCLUSIONS
  Diagnosis of EEC in asymptomatic patients or in patients with a short duration of bleeding is associated with comparable stage and survival.
authors.affiliation: Oncology Institute, Barzilai Medical Center, Ashkelon, Israel.
authors.forename: Frida
authors.initials: F
authors.lastname: Barak
authors.forename: Leonid
authors.initials: L
authors.lastname: Kalichman
authors.forename: Michael
authors.initials: M
authors.lastname: Gdalevich
authors.forename: Ronny
authors.initials: R
authors.lastname: Milgrom
authors.forename: Yael
authors.initials: Y
authors.lastname: Laitman
authors.forename: Benjamin
authors.initials: B
authors.lastname: Piura
authors.forename: Ofer
authors.initials: O
authors.lastname: Lavie
authors.forename: Ofer
authors.initials: O
authors.lastname: Gemer
mesh_terms: D000328:Adult; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000175:diagnosis* / Q000401:mortality* / Q000601:surgery; D015331:Cohort Studies; D055088:Early Detection of Cancer; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000601:surgery; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008875:Middle Aged; D009367:Neoplasm Staging; D016019:Survival Analysis; D016896:Treatment Outcome; D014592:Uterine Hemorrhage / Q000473:pathology; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery