title: Clinical outcomes strongly associated with the degree of reperfusion achieved in target mismatch patients: pooled data from the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution studies.
abstract: OBJECTIVE
  To investigate relationships between the degree of early reperfusion achieved on perfusion-weighted imaging and clinical outcomes in the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution studies. We hypothesized that there would be a strong correlation between the degree of reperfusion achieved and clinical outcomes in target mismatch (TMM) patients.
  
  
  METHODS
  The degree of reperfusion was calculated on the basis of the difference in perfusion-weighted imaging volumes (time to maximum of tissue residue function [Tmax]>6 s) between the baseline MRI and the early post-treatment follow-up scan. Patients were grouped into quartiles, on the basis of degree of reperfusion achieved, and the association between the degree of reperfusion and clinical outcomes in TMM and no TMM patients was assessed. Favorable clinical response was determined at day 30 on the basis of the National Institutes of Health Stroke Scale and good functional outcome was defined as a modified Rankin Scale score ≤2 at day 90.
  
  
  RESULTS
  This study included 121 patients; 98 of these had TMM. The median degree of reperfusion achieved was not different in TMM patients (60%) versus No TMM patients (64%; P=0.604). The degree of reperfusion was strongly correlated with both favorable clinical response (P<0.001) and good functional outcome (P=0.001) in TMM patients; no correlation was present in no TMM. The frequency of achieving favorable clinical response or good functional outcome was significantly higher in TMM patients in the highest reperfusion quartile versus the lower 3 quartiles (88% versus 41% as odds ratio, 10.3; 95% confidence interval, 2.8-37.5; and 75% versus 34% as odds ratio, 5.9; 95% confidence interval, 2.1-16.7, respectively). A receiver operating characteristic curve analysis identified 90% as the optimal reperfusion threshold for predicting good functional outcomes.
  
  
  CONCLUSIONS
  The degree of reperfusion documented on perfusion-weighted imaging after reperfusion therapies corresponds closely with clinical outcomes in TMM patients. Reperfusion of ≥90% of the perfusion lesion is an appropriate goal for reperfusion therapies to aspire to.
authors.affiliation: Stanford Stroke Center, Stanford University School of Medicine, Stanford, CA 94305, USA. m1inoue@stanford.edu
authors.forename: Manabu
authors.initials: M
authors.lastname: Inoue
authors.forename: Michael
authors.initials: M
authors.lastname: Mlynash
authors.forename: Matus
authors.initials: M
authors.lastname: Straka
authors.forename: Stephanie
authors.initials: S
authors.lastname: Kemp
authors.forename: Tudor G
authors.initials: TG
authors.lastname: Jovin
authors.forename: Aaryani
authors.initials: A
authors.lastname: Tipirneni
authors.forename: Scott A
authors.initials: SA
authors.lastname: Hamilton
authors.forename: Michael P
authors.initials: MP
authors.lastname: Marks
authors.forename: Roland
authors.initials: R
authors.lastname: Bammer
authors.forename: Maarten G
authors.initials: MG
authors.lastname: Lansberg
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Albers
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic; D038524:Diffusion Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging / Q000295:instrumentation / Q000379:methods*; D015424:Reperfusion / Q000379:methods*; D012720:Severity of Illness Index; D020521:Stroke / Q000145:classification / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
keywords: acute stroke; endovascular treatment; magnetic resonance imaging; perfusion-weighted imaging; reperfusion