title: Preparation and characterization of novel microparticles based on poly(3-hydroxybutyrate-co-3-hydroxyoctanoate).
abstract: In this study, a novel poly(3-hydroxybutyrate-co-3-hydroxyoctanoate) (P(HB-HO)) microparticle with an encapsulated antibiotic (azithromycin, AZI) was prepared by the electrospinning method. The resulting microparticles were evaluated for surface morphology, particle size, drug loading, encapsulation efficiency, in vitro drug-release and degradation. The in vitro cytotoxicity and in vivo pharmacokinetics were also studied. The sizes of microparticles showed a narrow monodisperse size distribution approximately from 3 to 30 µm. In vitro release experiments exhibited sustained release behavior. The results of in vitro degradation tests demonstrated that the mass loss of the P(HB-HO) microparticles was 9.6% and the morphology varied greatly within 24 weeks. P(HB-HO) showed no cytotoxicity to fibroblast when incubated with blank P(HB-HO) microparticles during the tests. The in vivo pharmacokinetic study demonstrated that the microparticles exhibited longer circulation properties than free AZI. It is suggested that novel AZI-loaded P(HB-HO) microparticles can be utilized as a biodegradable and biocompatible drug delivery system.
authors.affiliation: School of Environment and Safety, Taiyuan University of Science and Technology , Taiyuan , P.R. China .
authors.forename: Chan
authors.initials: C
authors.lastname: Zhang
authors.forename: Yuefeng
authors.initials: Y
authors.lastname: Dong
authors.forename: Liangqi
authors.initials: L
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D017963:Azithromycin / Q000493:pharmacokinetics / Q000494:pharmacology; D002460:Cell Line; D016503:Drug Delivery Systems; D005260:Female; D008422:Materials Testing; D051379:Mice; D011091:Polyesters / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000094122:Polyhydroxybutyrates
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin; D011091:Polyesters; C476611:poly(3-hydroxybutyrate-co-3-hydroxyoctanoate); D000094122:Polyhydroxybutyrates