title: The evolution of the Anopheles 16 genomes project.
abstract: We report the imminent completion of a set of reference genome assemblies for 16 species of Anopheles mosquitoes. In addition to providing a generally useful resource for comparative genomic analyses, these genome sequences will greatly facilitate exploration of the capacity exhibited by some Anopheline mosquito species to serve as vectors for malaria parasites. A community analysis project will commence soon to perform a thorough comparative genomic investigation of these newly sequenced genomes. Completion of this project via the use of short next-generation sequence reads required innovation in both the bioinformatic and laboratory realms, and the resulting knowledge gained could prove useful for genome sequencing projects targeting other unconventional genomes.
authors.affiliation: Broad Institute, Cambridge, Massachusetts 02142, USA. neafsey@broadinstitute.org
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Neafsey
authors.forename: George K
authors.initials: GK
authors.lastname: Christophides
authors.forename: Frank H
authors.initials: FH
authors.lastname: Collins
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Emrich
authors.forename: Michael C
authors.initials: MC
authors.lastname: Fontaine
authors.forename: William
authors.initials: W
authors.lastname: Gelbart
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Hahn
authors.forename: Paul I
authors.initials: PI
authors.lastname: Howell
authors.forename: Fotis C
authors.initials: FC
authors.lastname: Kafatos
authors.forename: Daniel
authors.initials: D
authors.lastname: Lawson
authors.forename: Marc A T
authors.initials: MA
authors.lastname: Muskavitch
authors.forename: Robert M
authors.initials: RM
authors.lastname: Waterhouse
authors.forename: Louise J
authors.initials: LJ
authors.lastname: Williams
authors.forename: Nora J
authors.initials: NJ
authors.lastname: Besansky
mesh_terms: D000818:Animals; D000852:Anopheles / Q000235:genetics*; D001483:Base Sequence; D005075:Biological Evolution; D019295:Computational Biology; D049750:Genome, Insect; D023281:Genomics; D006801:Humans; D007303:Insect Vectors / Q000235:genetics; D008288:Malaria / Q000235:genetics* / Q000469:parasitology / Q000635:transmission; D017422:Sequence Analysis, DNA
keywords: assembly; collaboration; comparative; malaria; vector