title: Stereoselective direct reductive amination of ketones with electron-deficient amines using Re2O7/NaPF6 catalyst.
abstract: The first example of direct reductive amination (DRA) of ketones with electron-deficient amines (EDA) such as Cbz-, Boc-, EtOCO-, Fmoc-, Bz-, ArSO2-, etc. protected amines have been achieved using catalytic Re2O7/NaPF6. Excellent chemoselectivities as well as diastereoselectivity (for 2-alkyl cyclohexanones) were obtained.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal-462023, India.
authors.forename: Braja Gopal
authors.initials: BG
authors.lastname: Das
authors.forename: Prasanta
authors.initials: P
authors.lastname: Ghorai
mesh_terms: D000586:Amination; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D054879:Halogenation; D007659:Ketones / Q000737:chemistry*; D010084:Oxidation-Reduction; D010710:Phosphates / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D007659:Ketones; D010710:Phosphates; C015428:perrhenate; D012211:Rhenium; C018279:sodium phosphate