title: D-pantethine has vitamin activity equivalent to d-pantothenic acids for recovering from a deficiency of D-pantothenic acid in rats.
abstract: D-Pantethine is a compound in which two molecules of D-pantetheine bind through an S-S linkage. D-Pantethine is available from commercial sources as well as from D-pantothenic acid. We investigated if D-pantethine has the same vitamin activity as D-pantothenic acid by comparing the recovery from a deficiency of D-pantothenic acid in rats. D-Pantothenic acid-deficient rats were developed by weaning rats on a diet lacking D-pantothenic acid for 47 d. At that time, the urinary excretion of D-pantothenic acid was almost zero, and the body weight extremely low, compared with the control (p<0.05); the contents of free D-pantothenic acid were also significantly reduced in comparison with those of controls (p<0.05). D-Pantothenic acid-deficient rats were administered a diet containing D-pantothenic acid or D-pantethine for 7 d. D-Pantethine and D-pantothenic acid contents of the diets were equimolar in forms of D-pantothenic acid. We compared various parameters concerning nutritional status between rats fed D-pantothenic acid- and D-pantethine-containing diets. The recoveries of body weight, tissue weights, and tissue concentrations of free D-pantothenic acid, dephospho-CoA, CoA, and acetyl-CoA were identical between rats fed diets containing D-pantothenic acid and D-pantethine. Thus, the biological efficiency for recovering from a deficiency of D-pantothenic acid in rats was equivalent between D-pantothenic acid and D-pantethine.
authors.affiliation: Department of Food Science and Nutrition, School of Human Cultures, University of Shiga Prefecture, Hikone, Shiga, Japan. kshibata@she.usp.ac.jp
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shibata
authors.forename: Mayu
authors.initials: M
authors.lastname: Kaneko
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fukuwatari
mesh_terms: D000105:Acetyl Coenzyme A / Q000032:analysis; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003065:Coenzyme A / Q000032:analysis; D004032:Diet; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010204:Pantetheine / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D010205:Pantothenic Acid / Q000097:blood / Q000172:deficiency* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014815:Vitamins / Q000097:blood / Q000494:pharmacology*; D014886:Weaning
chemical_list: D014815:Vitamins; D010205:Pantothenic Acid; C015787:dephosphocoenzyme A; D010204:Pantetheine; D000105:Acetyl Coenzyme A; C005425:pantethine; D003065:Coenzyme A