title: Synthesis and antimicrobial evaluation of some novel 1,2,4-triazole and 1,3,4-thiadiazole derivatives.
abstract: This study presents the synthesis and spectral analysis of new derivatives of 1,2,4-triazole-3-thione and 1,3,4-thiadiazole. New compounds were prepared by cyclization reaction of acyl thiosemicarbazide derivatives in the presence of alkaline and acidic media. All synthesized compounds were screened for their in vitro antibacterial activity by using the agar dilution technique. Six of the compounds had potential activity against Gram-positive bacteria (minimal inhibitory concentration [MIC] = 15.63-500 μg/mL). Some compounds showed good activity especially againstBacillus subtilisATCC 6633 (MIC = 15.63-250 μg/mL),Staphylococcus aureusATCC 25923 (MIC = 31.25-250 μg/mL), andMicrococcus luteusATCC 10240 (MIC = 125-250 μg/mL).
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Lublin, Poland.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Popiołek
authors.forename: Urszula
authors.initials: U
authors.lastname: Kosikowska
authors.forename: Liliana
authors.initials: L
authors.lastname: Mazur
authors.forename: Maria
authors.initials: M
authors.lastname: Dobosz
authors.forename: Anna
authors.initials: A
authors.lastname: Malm
keywords: 1,2,4-Triazole derivatives; 1,3,4-Thiadiazole derivatives; Antimicrobial activity