title: Thiol-addition reactions and their applications in thiol recognition.
abstract: Because of the biological importance of thiols, the development of probes for thiols has been an active research area in recent years. In this review, we summarize the results of recent exciting reports regarding thiol-addition reactions and their applications in thiol recognition. The examples reported can be classified into four reaction types including 1,1, 1,2, 1,3, 1,4 addition reactions, according to their addition mechanisms, based on different Michael acceptors. In all cases, the reactions are coupled to color and/or emission changes, although some examples dealing with electrochemical recognition have also been included. The use of thiol-addition reactions is a very simple and straightforward procedure for the preparation of thiol-sensing probes.
authors.affiliation: Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China.
authors.forename: Caixia
authors.initials: C
authors.lastname: Yin
authors.forename: Fangjun
authors.initials: F
authors.lastname: Huo
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhang
authors.forename: Ramón
authors.initials: R
authors.lastname: Martínez-Máñez
authors.forename: Yutao
authors.initials: Y
authors.lastname: Yang
authors.forename: Haigang
authors.initials: H
authors.lastname: Lv
authors.forename: Sidian
authors.initials: S
authors.lastname: Li
mesh_terms: D003545:Cysteine / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry; D006710:Homocysteine / Q000737:chemistry; D006801:Humans; D008024:Ligands; D015335:Molecular Probes / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D008024:Ligands; D015335:Molecular Probes; D013438:Sulfhydryl Compounds; D006710:Homocysteine; D005978:Glutathione; D003545:Cysteine