title: A preliminary study of the effect of DBD plasma and osmolytes on T98G brain cancer and HEK non-malignant cells.
abstract: Non-thermal plasmas are emerging as a novel tool for the treatment of living tissues for biological and medical purpose. In this study, we described the effect of 4 min dielectric barrier discharge (DBD) plasma on both T98G cancer and HEK normal cell lines in the presence of different concentrations of osmolytes. This treatment strategy shows a specific inhibitory effect of a 240 s plasma exposure in the presence of osmolytes against T98G brain cancer cells only, but not on HEK normal cells. Based on these interesting properties of osmolytes, a non-thermal plasma appears to be a potential anticancer treatment strategy for different kinds of cancers in the presence of osmolytes.
authors.affiliation: Plasma Bioscience Research Center, Kwangwoon University, Seoul 139701, Korea. kaushik.nagendra@gmail.com
authors.forename: Nagendra Kumar
authors.initials: NK
authors.lastname: Kaushik
authors.forename: Pankaj
authors.initials: P
authors.lastname: Attri
authors.forename: Neha
authors.initials: N
authors.lastname: Kaushik
authors.forename: Eun Ha
authors.initials: EH
authors.lastname: Choi
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D045744:Cell Line, Tumor; D003451:Cryoprotective Agents / Q000494:pharmacology*; D005990:Glycerol / Q000494:pharmacology*; D057809:HEK293 Cells; D006801:Humans; D008744:Methylamines / Q000494:pharmacology*; D009995:Osmosis / Q000187:drug effects; D013395:Sucrose / Q000494:pharmacology*; D013549:Sweetening Agents / Q000494:pharmacology*
chemical_list: D003451:Cryoprotective Agents; D008744:Methylamines; D013549:Sweetening Agents; D013395:Sucrose; C005855:trimethyloxamine; D005990:Glycerol