title: Concise synthesis of heterocycle-fused naphthoquinones by employing sonogashira coupling and tandem addition-elimination/intramolecular cyclization.
abstract: A concise method for the synthesis of heterocycle-fused naphthoquinones such as naphtho[2,3-b]-furan-4,9-dione, 1H-benz[f]indole-4,9-dione, and naphtho[2,3-b]thiophene-4,9-dione was developed. This method employed Sonogashira coupling and tandem addition-elimination/intramolecular cyclization, and it enabled the preparation of versatile heterocycle-fused naphthoquinones from one substrate.
authors.affiliation: School of Agriculture, Kinki University, Nakamachi, Nara, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ueda
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Yamashita
authors.forename: Koichi
authors.initials: K
authors.lastname: Sakaguchi
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Akira
authors.initials: A
authors.lastname: Iida
mesh_terms: D000114:Acetylene / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D009285:Naphthoquinones; D000114:Acetylene