title: Left ventricular functional changes after adenosine vasodilator stress evaluated by gated single-photon emission computed tomography.
abstract: OBJECTIVE
  Gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging is useful in assessing left ventricular (LV) myocardial perfusion and function. This study evaluated the LV functional changes after adenosine vasodilator stress, using gated SPECT.
  
  
  METHODS
  The study population consisted of 70 patients who underwent adenosine-mediated stress and rest SPECT. All patients underwent coronary angiography. Semi-quantitative assessment of perfusion was analyzed and produced the summed rest score (SRS), the summed stress score (SSS) and the summed difference score (SDS). The global LV function parameters [ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV)] and regional LV function [the summed motion score (SMS) and the summed thickening score (STS)] were quantified by gated SPECT.
  
  
  RESULTS
  Patients were divided into 2 groups: group 1 comprised 16 patients with worsening of LVEF (LVEFrest-LVEFado ≥5%), and group 2 comprised the other 54 patients. Compared with group 2, patients in group 1 had a significantly higher SSS and SDS (9.1 ± 6.8 vs. 5.6 ± 4.5 and 6.6 ± 3.8 vs. 3.6 ± 4.0, respectively; p < 0.05) and the severity of coronary artery stenosis was more serious (p < 0.05).
  
  
  CONCLUSIONS
  Worsening of LVEF after adenosine-induced vasodilator stress, as shown by (99m)Tc-MIBI gated SPECT, is a valuable nonperfusion marker of significant CAD.
authors.affiliation: Department of Nuclear Medicine, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Yue-Qin
authors.initials: YQ
authors.lastname: Tian
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zhang
authors.forename: Xiao-Xin
authors.initials: XX
authors.lastname: Sun
authors.forename: Feng
authors.initials: F
authors.lastname: Guo
authors.forename: Hong-Xing
authors.initials: HX
authors.lastname: Wei
authors.forename: Yin-Ying
authors.initials: YY
authors.lastname: Xu
authors.forename: Zuo-Xiang
authors.initials: ZX
authors.lastname: He
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D000368:Aged; D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology; D013318:Stroke Volume; D014665:Vasodilator Agents / Q000494:pharmacology; D016277:Ventricular Function, Left
chemical_list: D014665:Vasodilator Agents; D000241:Adenosine