title: NDRG3 and NDRG4, two novel tumor-related genes.
abstract: The N-myc downstream-regulated genes, NDRG3 and NDRG4, are suggested to play important roles in biological processes and pathogenesis. Expression of NDRG3 and NDRG4 has been shown to be reduced or absent in numerous cancer cell lines and tumor types, suggesting that they may exert function as a tumor suppressor gene. In this review, we will summarize the current research on NDRG3 and NDRG4, including the molecular structure, cellular and tissue distribution, biological function, and function in cancer. We tried to show their significance in studying disease and their therapeutic potential.
authors.affiliation: Jining Medical University, Jining, Shandong Province, PR China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Yang
authors.forename: Liangxiang
authors.initials: L
authors.lastname: An
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
mesh_terms: D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D009369:Neoplasms / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009124:Muscle Proteins; C431706:NDRG3 protein, human; C431705:NDRG4 protein, human; D009419:Nerve Tissue Proteins
keywords: Cancer; Myc; NDRG3; NDRG4