title: Personalization of a cardiac electromechanical model using reduced order unscented Kalman filtering from regional volumes.
abstract: Patient-specific cardiac modeling can help in understanding pathophysiology and therapy planning. However it requires to combine functional and anatomical data in order to build accurate models and to personalize the model geometry, kinematics, electrophysiology and mechanics. Personalizing the electromechanical coupling from medical images is a challenging task. We use the Bestel-Clément-Sorine (BCS) electromechanical model of the heart, which provides reasonable accuracy with a reasonable number of parameters (14 for each ventricle) compared to the available clinical data at the organ level. We propose a personalization strategy from cine MRI data in two steps. We first estimate global parameters with an automatic calibration algorithm based on the Unscented Transform which allows to initialize the parameters while matching the volume and pressure curves. In a second step we locally personalize the contractilities of all AHA (American Heart Association) zones of the left ventricle using the reduced order unscented Kalman filtering on Regional Volumes. This personalization strategy was validated synthetically and tested successfully on eight healthy and three pathological cases.
authors.affiliation: INRIA, Asclepios Research Project, Sophia Antipolis, France. Stephanie.Marchesseau@inria.fr
authors.forename: S
authors.initials: S
authors.lastname: Marchesseau
authors.forename: H
authors.initials: H
authors.lastname: Delingette
authors.forename: M
authors.initials: M
authors.lastname: Sermesant
authors.forename: R
authors.initials: R
authors.lastname: Cabrera-Lozoya
authors.forename: C
authors.initials: C
authors.lastname: Tobon-Gomez
authors.forename: P
authors.initials: P
authors.lastname: Moireau
authors.forename: R M
authors.initials: RM
authors.lastname: Figueras i Ventura
authors.forename: K
authors.initials: K
authors.lastname: Lekadir
authors.forename: A
authors.initials: A
authors.lastname: Hernandez
authors.forename: M
authors.initials: M
authors.lastname: Garreau
authors.forename: E
authors.initials: E
authors.lastname: Donal
authors.forename: C
authors.initials: C
authors.lastname: Leclercq
authors.forename: S G
authors.initials: SG
authors.lastname: Duckett
authors.forename: K
authors.initials: K
authors.lastname: Rhode
authors.forename: C A
authors.initials: CA
authors.lastname: Rinaldi
authors.forename: A F
authors.initials: AF
authors.lastname: Frangi
authors.forename: R
authors.initials: R
authors.lastname: Razavi
authors.forename: D
authors.initials: D
authors.lastname: Chapelle
authors.forename: N
authors.initials: N
authors.lastname: Ayache
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D056966:Excitation Contraction Coupling / Q000502:physiology; D006329:Heart Conduction System / Q000502:physiology*; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology*; D009929:Organ Size; D057285:Precision Medicine / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: Cardiac mechanics; Medical images; Patient-specific models; Reduced order unscented Kalman filtering; Regional volumes