title: Hyperandrogenism is associated with earlier age of onset of idiopathic intracranial hypertension in women.
abstract: OBJECTIVE
  Previous reports have connected between Idiopathic intracranial hypertension (IIH), obesity and different hormonal states. The aim of this study was to characterize the endocrine profile in women with IIH.
  
  
  METHODS
  This is a data-based study of 51 IIH patients. We measured anthropometric parameters and assessed hormonal profile including cortisol, testosterone, bioavailable testosterone (BT), prolactin, dehydroepiandrosterone sulfate (DHEA-S), androstenedione, insulin, aldosterone, estradiol, follicle stimulating hormone (FSH) and luteinizing hormone (LH). Pearson or Spearman rank correlation for non-normally distributed variables were calculated to evaluate the relation among the anthropometric measurements: age, body mass index (BMI), waist and hip circumference and waist to hip ratio (WHR) with hormones levels.
  
  
  RESULTS
  Seventy-eight percent of the cohort had WHR < 0.85 and 21.6% had a WHR > 0.85. Increased levels of testosterone, BT and androstenedione were all positively related to younger age of diagnosis in patient who are diagnosed after the age of 25 (R = -1.066, -0.845, -0.735, p < 0.001, =0.024, 0.019, respectively). No correlation was found between any of the analyzed hormones and the duration of the disease, WHR or BMI, except insulin, which was positively related to BMI (R = 0.461, p = 0.001).
  
  
  CONCLUSIONS
  Increased levels of circulating androgens are associated with earlier age of onset of IIH in women.
authors.affiliation: Neuro-ophthalmology Unit, Department of Ophthalmology, Tel Aviv-Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. euriya@gmail.com
authors.forename: Ainat
authors.initials: A
authors.lastname: Klein
authors.forename: Naftali
authors.initials: N
authors.lastname: Stern
authors.forename: Etty
authors.initials: E
authors.lastname: Osher
authors.forename: Efrat
authors.initials: E
authors.lastname: Kliper
authors.forename: Anat
authors.initials: A
authors.lastname: Kesler
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000450:Aldosterone / Q000097:blood; D000735:Androstenedione / Q000097:blood; D050218:Body Fat Distribution; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D017588:Hyperandrogenism / Q000097:blood* / Q000150:complications*; D007328:Insulin / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D011388:Prolactin / Q000097:blood; D011559:Pseudotumor Cerebri / Q000097:blood* / Q000150:complications*; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D043373:Follicle Stimulating Hormone, Human; D007328:Insulin; D013739:Testosterone; D000735:Androstenedione; D000450:Aldosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D011388:Prolactin; D007986:Luteinizing Hormone; D006854:Hydrocortisone