title: Different phylogenetic profile and reduced mannose-sensitive adherence capacity characterize commensal Escherichia coli in IgA deficient individuals.
abstract: In IgA deficiency, secretory IgA (S-IgA) is absent from intestinal secretions. S-IgA carbohydrate chains act as receptors for the mannose specific (MS) adhesin fim of Escherichia coli. In IgA deficient (IgAd) individuals, commensal E. coli express less MS adherence to epithelial cells, due both to reduced carriage of the fimH adhesin gene, reduced capacity to switch it on, and reduced adherence of adhesin-expressing bacteria. Here, we show that commensal E. coli microbiota of IgA deficient individuals belong to phylogenetic group A and display low MS adherence. In healthy individuals, group B2 with strong MS adherence dominate.
authors.affiliation: Institution for Biomedicine, Department of Infectious Disease, University of Gothenburg, Gothenburg, Sweden. forough.nowrouzian@microbio.gu.se
authors.forename: Forough L
authors.initials: FL
authors.lastname: Nowrouzian
authors.forename: Vanda
authors.initials: V
authors.lastname: Friman
authors.forename: Ingegerd
authors.initials: I
authors.lastname: Adlerberth
authors.forename: Agnes E
authors.initials: AE
authors.lastname: Wold
mesh_terms: D018830:Adhesins, Escherichia coli / Q000235:genetics / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D001422:Bacterial Adhesion / Q000235:genetics / Q000502:physiology*; D003106:Colon / Q000382:microbiology*; D004926:Escherichia coli / Q000145:classification / Q000235:genetics* / Q000502:physiology*; D005260:Female; D036781:Fimbriae Proteins / Q000235:genetics / Q000378:metabolism; D010861:Fimbriae, Bacterial / Q000235:genetics; D019073:HT29 Cells; D006801:Humans; D017098:IgA Deficiency / Q000382:microbiology*; D007070:Immunoglobulin A; D008297:Male; D008358:Mannose / Q000378:metabolism*; D008875:Middle Aged; D010802:Phylogeny; D055815:Young Adult
chemical_list: D018830:Adhesins, Escherichia coli; D007070:Immunoglobulin A; C058769:fimH protein, E coli; D036781:Fimbriae Proteins; D008358:Mannose
keywords: Commensal E. coli; IgA deficiency; Mannose-sensitive adherence; Phylogenetic group; Secretory IgA