title: miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII.
abstract: miR-211 up-regulation and transforming growth factor-β type II receptor (TGFβRII) down-regulation are associated with poor prognosis of head and neck squamous cell carcinoma (HNSCC). miR-211 directly targets TGFβRII with the miR-211-TGFβRII-c-Myc axis promoting HNSCC progression. An inverse correlation of miR-211 and TGFβRII expression was found in metastatic HNSCC samples. After 4-nitroquinoline 1-oxide induction, more severe epithelial tumorigenesis was detected on K14-miR-211 transgenic mouse dorsal tongues. Human metastatic lesions and mouse tongue tumors showed increased nuclear c-Myc expression. A novel role for miR-211 in the regulation of TGFβRII and c-Myc during tumorigenesis being revealed should help to develop anti-HNSCC therapies.
authors.affiliation: Institute of Oral Biology, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Ting-Hui
authors.initials: TH
authors.lastname: Chu
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Yang
authors.forename: Chung-Ji
authors.initials: CJ
authors.lastname: Liu
authors.forename: Mann-Tin
authors.initials: MT
authors.lastname: Lui
authors.forename: Shu-Chun
authors.initials: SC
authors.lastname: Lin
authors.forename: Kuo-Wei
authors.initials: KW
authors.lastname: Chang
mesh_terms: D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000235:genetics; D018450:Disease Progression; D016259:Genes, myc; D006258:Head and Neck Neoplasms / Q000209:etiology* / Q000235:genetics; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics*; D051900:Smad3 Protein / Q000378:metabolism; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: C549405:MIRN211 microRNA, human; D035683:MicroRNAs; D018125:Receptors, Transforming Growth Factor beta; C497790:SMAD3 protein, human; D051900:Smad3 Protein; D015112:4-Nitroquinoline-1-oxide; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II
keywords: Carcinoma; Head and neck; TGFβRII; Transgenic mouse; c-Myc; miR-211