title: Aldol reactions in multicomponent reaction based domino pathways: a multipurpose enabling tool in heterocyclic chemistry.
abstract: The aldol reaction has been evaluated in combination with the Ugi multicomponent reaction to assemble richly decorated mono- and polycyclic systems via expeditious cascade pathways. A small collection of pyrrolinones was generated thereof, and the scarcely accessible pyridoquinoxalinedione scaffold was also prepared by designing an additional nucleophilic substitution step in this domino sequence requiring minimal operational effort.
authors.affiliation: College of Pharmacy, BIO5 Oro Valley, The University of Arizona, Oro Valley, Arizona 85737, USA.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Xu
authors.forename: Fabio
authors.initials: F
authors.lastname: De Moliner
authors.forename: Alexandra P
authors.initials: AP
authors.lastname: Cappelli
authors.forename: Christopher
authors.initials: C
authors.lastname: Hulme
mesh_terms: D006571:Heterocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D055601:Organic Chemistry Phenomena; D011725:Pyridines / Q000737:chemistry*; D011810:Quinoxalines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D011725:Pyridines; D011810:Quinoxalines