title: [Prevalence and sequence of metaplasia-dysplasia-carcinoma of the gallbladder. A single centre retrospective study].
abstract: BACKGROUND
  We report the frequency and age of metaplasia, dysplasia and carcinoma of the gallbladder, and seek to establish a sequence of progression of these, since several studies suggest that this is the carcinogenesis pathway.
  
  
  METHODS
  Descriptive retrospective cross-sectional study over a period of 4 years, with an analytical component of 1,514 patients with cholelithiasis, in whom cholecystectomy were performed.
  
  
  RESULTS
  The mean age of the sample was 46 years and 72% of patients were female. The prevalence (and mean age) of pyloric metaplasia, intestinal metaplasia, dysplasia and carcinoma was 22.6 (47), 2.1 (46), 0.2 (54) and 0.6% (63 years), respectively. There was a significant association between intestinal and pyloric metaplasia (P<.001, chi(2)) and between dysplasia and carcinoma (P<.005, Yates), but not between metaplasia and dysplasia.
  
  
  CONCLUSIONS
  Improved studies should be conducted for the correct interpretation of the pathogenesis of gallbladder cancer.
authors.affiliation: II Cátedra de Clínica Quirúrgica, Hospital de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Asunción, Asunción, Paraguay. Electronic address: hhaassll@gmail.com.
authors.forename: Helmut Alfredo
authors.initials: HA
authors.lastname: Segovia Lohse
authors.forename: Osmar Manuel
authors.initials: OM
authors.lastname: Cuenca Torres
mesh_terms: D002277:Carcinoma / Q000453:epidemiology* / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D005706:Gallbladder Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D006801:Humans; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies
keywords: Carcinoma; Displasia; Dysplasia; Gallbladder neoplasms; Metaplasia; Neoplasias de la vesícula biliar