title: [Effect of artificial cerebrospinal fluid lavage time on the edema of traumatic brain injury].
abstract: OBJECTIVE
  To detect the impact of artificial cerebrospinal fluid lavage time on the edema of traumatic brain injury.
  
  
  METHODS
  A total of 240 SD rats were randomly divided into a sham group, a traumatic brain injury model group, 3 artificial cerebrospinal fluid lavage groups (3 h, 6 h and 9 h). Each group was divided into 4 sub-groups by time of sacrifice namely 12 h, 1 d, 3 d and 7 d postoperatively. We detected the content of brain water, sodium, and potassium, and the VEGF expression to confirm whether the duration of lavage could reduce the traumatic brain edema.
  
  
  RESULTS
  Compared with the sham group and the traumatic brain injury model group, brain water content and sodium content were decreased, while the potassium content and the VEGF levels were increased in the artificial cerebrospinal fluid lavage groups. Significant difference was found at 12 h, 1 d, and 3 d after the injury (P<0.05). With the increase of artificial cerebrospinal fluid lavage time, the difference was more obvious.
  
  
  CONCLUSIONS
  Artificial cerebrospinal fluid lavage can reduce the brain edema after traumatic brain injury. The longer the lavage, the more obvious the effect.
authors.affiliation: Department of Neurosurgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Jiaode
authors.initials: J
authors.lastname: Jiang
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Wenhua
authors.initials: W
authors.lastname: Fang
authors.forename: Yunsheng
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D001929:Brain Edema / Q000209:etiology / Q000517:prevention & control*; D001930:Brain Injuries / Q000150:complications*; D002555:Cerebrospinal Fluid; D008297:Male; D009995:Osmosis; D019999:Pharmaceutical Solutions / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D007507:Therapeutic Irrigation / Q000379:methods
chemical_list: D019999:Pharmaceutical Solutions