title: Rhythmic modulation of the hematopoietic niche through neutrophil clearance.
abstract: Unique among leukocytes, neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. Because removal of dying cells generates homeostatic signals, we explored whether neutrophil elimination triggers circadian events in the steady state. Here, we report that the homeostatic clearance of neutrophils provides cues that modulate the physiology of the bone marrow. We identify a population of CD62L(LO) CXCR4(HI) neutrophils that have "aged" in the circulation and are eliminated at the end of the resting period in mice. Aged neutrophils infiltrate the bone marrow and promote reductions in the size and function of the hematopoietic niche. Modulation of the niche depends on macrophages and activation of cholesterol-sensing nuclear receptors and is essential for the rhythmic egress of hematopoietic progenitors into the circulation. Our results unveil a process that synchronizes immune and hematopoietic rhythms and expand the ascribed functions of neutrophils beyond inflammation. PAPERFLICK:
authors.affiliation: Department of Epidemiology, Atherothrombosis and Imaging, Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Casanova-Acebes
authors.forename: Christophe
authors.initials: C
authors.lastname: Pitaval
authors.forename: Linnea A
authors.initials: LA
authors.lastname: Weiss
authors.forename: César
authors.initials: C
authors.lastname: Nombela-Arrieta
authors.forename: Raphaël
authors.initials: R
authors.lastname: Chèvre
authors.forename: Noelia
authors.initials: N
authors.lastname: A-González
authors.forename: Yuya
authors.initials: Y
authors.lastname: Kunisaki
authors.forename: Dachuan
authors.initials: D
authors.lastname: Zhang
authors.forename: Nico
authors.initials: N
authors.lastname: van Rooijen
authors.forename: Leslie E
authors.initials: LE
authors.lastname: Silberstein
authors.forename: Christian
authors.initials: C
authors.lastname: Weber
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagasawa
authors.forename: Paul S
authors.initials: PS
authors.lastname: Frenette
authors.forename: Antonio
authors.initials: A
authors.lastname: Castrillo
authors.forename: Andrés
authors.initials: A
authors.lastname: Hidalgo
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000502:physiology*; D002465:Cell Movement; D016922:Cellular Senescence; D002940:Circadian Rhythm; D005260:Female; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006706:Homeostasis; D000071518:Liver X Receptors; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000166:cytology* / Q000276:immunology / Q000502:physiology*; D057093:Orphan Nuclear Receptors / Q000378:metabolism
chemical_list: D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors