title: Etiologic influence on chromosomal aberrations in European hepatocellular carcinoma identified by CGH.
abstract: Previous studies suggest different pathways in the molecular development of hepatocellular carcinoma (HCC). We investigated the pattern of chromosomal imbalances in HCC depending on the type of underlying liver disease as detected by comparative genomic hybridization in 67 cases of primary HCC occurring in non-cirrhotic livers (n=30), in liver cirrhosis (LC) related to alcohol intake (n=9), cryptogenic or metabolic changes (n=11), and chronic viral hepatitis B or C (n=17). HCC were treated by liver resection in 48 patients and transplantation in 19 patients. The 10-year disease-free and overall survival rates were 51% and 68%, respectively. The copy number changes occurring in more than 10% of cases were gains at 8q (55%), 1q (49%), 7q (15%), 7p (13%), 6p (12%), and 20q (12%), as well as losses at 8p (55%), 4q (33%), 6q (33%), 13q (25%), 14q (24%), 17p (22%), 16q (19%), 1p (18%), 18q (16%), 9p (13%), 10q (13%), 4p (12%), and 9q (12%). HCC arising in alcoholic LC showed a different pattern with significantly fewer net changes (p=0.008), particularly fewer chromosomal gains (p=0.008) and fewer breakpoints (p=0.003) compared to the other investigated HCC subgroups. Future clinical studies should evaluate the prognostic relevance of these findings.
authors.affiliation: Department of General and Visceral Surgery, Georg August University of Göttingen, Germany. khomayounfar@chirurgie-goettingen.de
authors.forename: Kia
authors.initials: K
authors.lastname: Homayounfar
authors.forename: Alexandra
authors.initials: A
authors.lastname: Schwarz
authors.forename: Christina
authors.initials: C
authors.lastname: Enders
authors.forename: Silke
authors.initials: S
authors.lastname: Cameron
authors.forename: Daniel
authors.initials: D
authors.lastname: Baumhoer
authors.forename: Giuliano
authors.initials: G
authors.lastname: Ramadori
authors.forename: Thomas
authors.initials: T
authors.lastname: Lorf
authors.forename: Bastian
authors.initials: B
authors.lastname: Gunawan
authors.forename: Bjoern
authors.initials: B
authors.lastname: Sander
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000821:virology; D002869:Chromosome Aberrations; D055028:Comparative Genomic Hybridization; D018572:Disease-Free Survival; D005060:Europe / Q000453:epidemiology; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000235:genetics* / Q000401:mortality; D019698:Hepatitis C, Chronic / Q000150:complications / Q000235:genetics* / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008103:Liver Cirrhosis / Q000235:genetics* / Q000401:mortality / Q000821:virology; D008104:Liver Cirrhosis, Alcoholic / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000821:virology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome