title: Dual recognition of the human telomeric G-quadruplex by a neomycin-anthraquinone conjugate.
abstract: The authors report the recognition of a G-quadruplex formed by four repeat human telomeric DNA with aminosugar intercalator conjugates. The recognition of the G-quadruplex through dual binding mode ligands significantly increased the affinity of ligands for the G-quadruplex. One such example is a neomycin-anthraquinone conjugate (2) which exhibited nanomolar affinity for the quadruplex, and the affinity of (2) is nearly 1000 fold higher for the human telomeric G-quadruplex DNA than its constituent units, neomycin and anthraquinone.
authors.affiliation: Laboratory of Bioorganic and Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC 29634, USA.
authors.forename: Nihar
authors.initials: N
authors.lastname: Ranjan
authors.forename: Erik
authors.initials: E
authors.lastname: Davis
authors.forename: Liang
authors.initials: L
authors.lastname: Xue
authors.forename: Dev P
authors.initials: DP
authors.lastname: Arya
mesh_terms: D000880:Anthraquinones / Q000737:chemistry*; D001665:Binding Sites; D002942:Circular Dichroism; D054856:G-Quadruplexes; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry*; D008024:Ligands; D009355:Neomycin / Q000737:chemistry*; D009691:Nucleic Acid Denaturation; D044367:Phase Transition; D016615:Telomere / Q000737:chemistry*; D044366:Transition Temperature; D014466:Ultraviolet Rays
chemical_list: D000880:Anthraquinones; D007364:Intercalating Agents; D008024:Ligands; C042834:9,10-anthraquinone; D009355:Neomycin