title: Malignant melanoma: epidemiologic aspects, diagnostic and therapeutic approach.
abstract: In faired skinned population the incidence of melanoma is rapidly increasing. Beside environmental factors (UV-exposure) certainly other reasons for the observed "melanoma epidemic" have to be discussed. For diagnostic procedure classical histopathology is accompanied by immunohistochemistry and more recently molecular techniques. For therapy new modalities are available which-after many years of frustrating search for new drugs-are now able to prolong both disease/progression free and overall survival.
authors.affiliation: Department of Dermatology and Venereology, Hildesheim GmbH, Germany. M.Tronnier@klinikum-hildesheim.de
authors.forename: Michael
authors.initials: M
authors.lastname: Tronnier
authors.forename: Kristina
authors.initials: K
authors.lastname: Semkova
authors.forename: Uwe
authors.initials: U
authors.lastname: Wollina
authors.forename: Georgi
authors.initials: G
authors.lastname: Tchernev
mesh_terms: D001706:Biopsy; D003131:Combined Modality Therapy; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D018450:Disease Progression; D018572:Disease-Free Survival; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008545:Melanoma / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D025202:Molecular Diagnostic Techniques; D009367:Neoplasm Staging; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*