title: [Effect of infliximab on amino acid content in blood lymphocytes of alcohol-intoxicated rats].
abstract: Dose-dependent effects of monoclonal antibodies to tumor necrosis factor alpha (TNFa) in the form of infliximab preparation have been studied in Wistar rats upon with alcohol intoxication for 10 weeks (Lieber- De Carli liquid diet). It is established that the intraperitoneal administration of infliximab within the last 10 days of alcoholization in doses of 1 mg/kg and 10 mg/kg leads to dose-dependent changes in individual indices of the free amino acids pool and the amino acid balance in blood lymphocytes. Infliximab administered on the background of alcohol intoxication increases the pool of free amino acids and activates their metabolism in rat blood lymphocytes, which is probably due to inactivation of TNFalpha and adaptive changes in the amino acid transport system.
authors.forename: M V
authors.initials: MV
authors.lastname: Goretskaia
authors.forename: V M
authors.initials: VM
authors.lastname: Sheĭbak
authors.forename: E M
authors.initials: EM
authors.lastname: Doroshenko
authors.forename: P Ch
authors.initials: PCh
authors.lastname: Kirvel'
mesh_terms: D000435:Alcoholic Intoxication / Q000097:blood*; D000596:Amino Acids / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D000069285:Infliximab; D007274:Injections, Intraperitoneal; D008214:Lymphocytes / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000596:Amino Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000431:Ethanol; D000069285:Infliximab