title: P97/CDC-48: proteostasis control in tumor cell biology.
abstract: P97/CDC-48 is a prominent member of a highly evolutionary conserved Walker cassette - containing AAA+ATPases. It has been involved in numerous cellular processes ranging from the control of protein homeostasis to membrane trafficking through the intervention of specific accessory proteins. Expression of p97/CDC-48 in cancers has been correlated with tumor aggressiveness and prognosis, however the precise underlying molecular mechanisms remain to be characterized. Moreover p97/CDC-48 inhibitors were developed and are currently under intense investigation as anticancer drugs. Herein, we discuss the role of p97/CDC-48 in cancer development and its therapeutic potential in tumor cell biology.
authors.affiliation: Inserm U1045, Bordeaux, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Fessart
authors.forename: Esther
authors.initials: E
authors.lastname: Marza
authors.forename: Saïd
authors.initials: S
authors.lastname: Taouji
authors.forename: Frédéric
authors.initials: F
authors.lastname: Delom
authors.forename: Eric
authors.initials: E
authors.lastname: Chevet
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000502:physiology*; D000818:Animals; D001343:Autophagy; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D004249:DNA Damage; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D016328:NF-kappa B / Q000502:physiology; D009369:Neoplasms / Q000209:etiology* / Q000628:therapy; D000074405:Valosin Containing Protein
chemical_list: D018797:Cell Cycle Proteins; D016328:NF-kappa B; D000251:Adenosine Triphosphatases; C000614178:VCP protein, human; D000074405:Valosin Containing Protein
keywords: CDC-48; Cancer; Proteostasis; VCP; p97