title: New onset migraine with aura after treatment initiation with ivabradine.
abstract: BACKGROUND
  Migraine with aura is a complex neurological disorder modeled in animals by cortical spreading depression. It is less usual to find complete animal models for the disease so any opportunity to test a human effect back at the bench is welcome.
  
  
  RESULTS
  We report the case of a 24 year old woman who developed new onset episodic migraine with visual aura shortly after treatment initiation with the If ion channel blocker ivabradine for frequency control in hypertrophic cardiomyopathy. We studied whether ivabradine could alter cortical spreading depression in a suitable animal model. Sixteen rats received either ivabradine or saline, and the number of depolarization shifts and blood flow changes induced by cortical spreading depression were measured in both groups. No significant differences between the ivabradine and saline group were detected.
  
  
  CONCLUSIONS
  Ivabradine is an interesting substance since it is known to produce migraine-like phosphenes frequently and the patient we report developed de novo migraine with aura. However, we were unable to demonstrate that the drug influences the susceptibility of the brain to cortical spreading depression with acute administration. The combined data show the relationship of migraine aura to cortical spreading depression may have some nuances yet to be identified.
authors.forename: Till
authors.initials: T
authors.lastname: Sprenger
authors.forename: Weera
authors.initials: W
authors.lastname: Supronsinchai
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Goadsby
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D000818:Animals; D001552:Benzazepines / Q000009:adverse effects* / Q000494:pharmacology; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005260:Female; D006801:Humans; D000077550:Ivabradine; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D020325:Migraine with Aura / Q000139:chemically induced*; D051381:Rats; D017207:Rats, Sprague-Dawley; D055815:Young Adult
chemical_list: D001552:Benzazepines; D000077550:Ivabradine