title: The need for continuing chemotherapy for leukemic cell lysis pneumopathy in patients with acute myelomonocytic/monocytic leukemia.
abstract: Although fatal pulmonary complications frequently occur during the course of acute leukemia, a minor proportion of the complications are due to leukemia itself. Infections, drug reactions and concomitant medical conditions are the major causes of respiratory distress in leukemic patients. We treated four patients with acute myeloid leukemia complicated by leukemic cell lysis pneumopathy (LCLP). All of the patients had leukemia of monocytoid origin and their respiratory function deteriorated soon after chemotherapy initiation. Although two of the patients required mechanical ventilation, all four improved after continued chemotherapy. Our experience indicates that, in cases of LCLP, chemotherapy should be continued with maximal respiratory support.
authors.affiliation: Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital, Japan. aikokato0203@gmail.com
authors.forename: Aiko
authors.initials: A
authors.lastname: Kato
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ono
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nagahata
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Yamauchi
authors.forename: Sumie
authors.initials: S
authors.lastname: Tabata
authors.forename: Noboru
authors.initials: N
authors.lastname: Yonetani
authors.forename: Akiko
authors.initials: A
authors.lastname: Matsushita
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ishikawa
mesh_terms: D000293:Adolescent; D000368:Aged; D016923:Cell Death / Q000502:physiology; D005260:Female; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy*; D015479:Leukemia, Myelomonocytic, Acute / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy*; D017254:Leukemic Infiltration / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged