title: Surgical versus non-surgical treatment for thoracolumbar burst fractures without neurological deficit.
abstract: BACKGROUND
  Spinal burst fractures result from the failure of both the anterior and the middle columns of the spine under axial compression loads. Conservative management is through bed rest and immobilisation once the acute symptoms have settled. Surgical treatment involves either anterior or posterior stabilisation of the fracture, sometimes with decompression involving the removal of bone fragments that have intruded into the vertebral canal. This is an update of a review first published in 2006.
  
  
  OBJECTIVE
  To compare the outcomes of surgical with non-surgical treatment for thoracolumbar burst fractures without neurological deficit.
  
  
  METHODS
  We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register (October 2012), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 8), MEDLINE (1946 to October 2012), EMBASE (1980 to October 2012) and the Chinese Biomedical Literature Database (1978 to October 2012). We also searched trial registers and reference lists of articles.
  
  
  METHODS
  Randomised or quasi-randomised controlled trials comparing surgical with non-surgical treatment of thoracolumbar burst fractures without neurological deficit.
  
  
  METHODS
  Two review authors independently assessed risk of bias and extracted data independently. Only limited pooling of data was done.
  
  
  RESULTS
  We included two trials that compared surgical with non-surgical treatment for patients with thoracolumbar burst fractures without neurological deficit. These recruited a total of 87 participants and reported outcomes for 79 participants at follow-up of two years or more. Both trials were judged at unclear risk of selection bias and at high risk of performance and detection biases, resulting from lack of blinding.The two trials reported contrasting results for pain and function-related outcomes at final follow-up, and numbers returning to work. One trial found less pain (mean difference (MD) -15.09 mm, 95% CI -27.81 to -2.37; 100 mm visual analogue scale), and better function based on the Roland and Morris disability questionnaire results (MD -5.87, 95% CI -10.10 to -1.64; 24 points = maximum disability) in the surgical group. Based on the same outcome measures, the other trial found the surgical group had more pain (MD 13.60 mm, 95% CI -0.31 to 27.51) and worse function (MD 4.31, 95% CI 0.54 to 8.08). Neither trial reported a statistically significant difference in return to work. There were greater numbers of participants with complications in the surgical group of both trials (21/41 versus 6/38; RR 2.85, 95% CI 0.83 to 9.75; 2 trials), and only participants of this group had subsequent surgery, involving implant removal either for complications or as a matter of course. One trial reported that surgery was over four times more costly than non-surgical treatment.
  
  
  CONCLUSIONS
  The contradictory evidence provided by two small and potentially biased randomised controlled trials is insufficient to conclude whether surgical or non-surgical treatment yields superior pain and functional outcomes for people with thoracolumbar burst fractures without neurological deficit. It is likely, however, that surgery is associated with more early complications and the need for subsequent surgery, as well as greater initial healthcare costs.
authors.affiliation: The Eye Department of the First Affiliated Hospital, Xinjiang Medical University, Xinjiang, China.
authors.forename: Minawaer
authors.initials: M
authors.lastname: Abudou
authors.forename: Xueyi
authors.initials: X
authors.lastname: Chen
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Kong
authors.forename: Taixiang
authors.initials: T
authors.lastname: Wu
mesh_terms: D005592:Fracture Fixation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008159:Lumbar Vertebrae / Q000293:injuries*; D062707:Return to Work; D016103:Spinal Fractures / Q000601:surgery / Q000628:therapy*; D013904:Thoracic Vertebrae / Q000293:injuries*; D016896:Treatment Outcome