title: Mydriasis model in rats as a simple system to evaluate α2-adrenergic activity of the imidazol(in)e compounds.
abstract: Imidazol(in)e compounds show the diversity of pharmacological effects including mydriasis, hypotension, sedation, bradycardia and hypothermia. At first it was postulated that these effects are mediated via α2-adrenoceptors exclusively. Clonidine is well known as a model agent to produce pupillary dilation in rats. However, it became obvious later that clonidine-like imidazol(in)e adrenoceptor agonists which produced mydriasis in rats, exhibit also a high affinity for imidazoline I1-receptors. That short report attempts to review the present status of studies to confirm that the mydriasis model in rats can be a selective system to evaluate the α2-adrenergic activity of potential pharmacologically active compounds of imidazol(in)e structure.
authors.affiliation: Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Al Gen J Hallera 107, PL 80-416 Gdańsk, Poland. jrgutknecht@gumed.edu.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Raczak-Gutknecht
authors.forename: Teresa
authors.initials: T
authors.lastname: Frąckowiak
authors.forename: Antoni
authors.initials: A
authors.lastname: Nasal
authors.forename: Roman
authors.initials: R
authors.lastname: Kaliszan
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000494:pharmacology*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D004195:Disease Models, Animal; D006801:Humans; D054755:Imidazoline Receptors / Q000187:drug effects / Q000378:metabolism; D048288:Imidazolines / Q000494:pharmacology*; D023421:Models, Animal; D009184:Mydriatics / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects; D051381:Rats; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D054755:Imidazoline Receptors; D048288:Imidazolines; D009184:Mydriatics; D018341:Receptors, Adrenergic, alpha-2; C410887:imidazoline I1 receptors; D003000:Clonidine