title: Targeting cathepsin G in myeloid leukemia.
abstract: Cathepsin G (CG) is a serine protease normally found within the azurophil granules of neutrophils. CG is expressed during the early stages of normal myeloid differentiation and-aberrantly-by myeloid leukemia cells. We have recently identified CG-derived HLA-A*0201-binding peptides that constitute promising targets for the immunotherapy of myeloid leukemia.
authors.affiliation: Section of Transplant Immunology; Department of Stem Cell Transplantation and Cellular Therapy; University of Texas MD Anderson Cancer Center; Houston, TX USA.
authors.forename: Gheath
authors.initials: G
authors.lastname: Alatrash
keywords: AML; antigen; azurophil; cathepsin G; granule; immunotherapy; leukemia; myeloid; protease; target