title: Stereotactic body radiation therapy in stage I inoperable lung cancer: from palliative to curative options.
abstract: Surgery has historically been the standard of care for operable stage I non-small cell lung cancer (NSCLC). However, nearly one-quarter of patients with stage I NSCLC will not undergo surgery because of medical comorbidity or other factors. Stereotactic ablative radiotherapy (SABR) is the new standard of care for these patients. SABR offers high local tumour control rates rivalling the historical results of surgery and is generally well tolerated by patients with both peripheral and centrally located tumours. This article reviews the history of SABR for stage I NSCLC, summarises the currently available data on efficacy and toxicity, and describes some of the currently controversial aspects of this treatment.
authors.affiliation: Service de radio-oncologie, Centre Hospitalier Universitaire Habib Bourguiba, Sfax, Tunisia; Service de radio-oncologie, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland; Service de radio-oncologie, Département Valaisan d’Oncologie, Hôpital de Sion-CHCVs-RSV, Sion, Switzerland. nboujelbene@gmail.com
authors.forename: Noureddine
authors.initials: N
authors.lastname: Boujelbene
authors.forename: Fatma
authors.initials: F
authors.lastname: Elloumi
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Kamel
authors.forename: Hamdi
authors.initials: H
authors.lastname: Abeidi
authors.forename: Oscar
authors.initials: O
authors.lastname: Matzinger
authors.forename: René-Olivier
authors.initials: RO
authors.lastname: Mirimanoff
authors.forename: Kaouthar
authors.initials: K
authors.lastname: Khanfir
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000601:surgery*; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery*; D010166:Palliative Care / Q000379:methods; D016634:Radiosurgery / Q000379:methods*; D016896:Treatment Outcome