title: Antinocieptive and anti-inflammatory effects of Toddalia asiatica (L) Lam. (Rutaceae) root extract in Swiss albino mice.
abstract: BACKGROUND
  Toddalia asiatica is a commonly used medicinal plant in East Africa for the management of pain and inflammatory conditions. The present study investigated the antinociceptive and the anti-inflammatory effects of T. asiatica in Swiss albino mice.
  
  
  METHODS
  The antinociceptive and the anti-inflammatory effects of T. asiatica were investigated using formalin-induced pain test and the carrageenin-induced oedema paw. The extract solvent (vehicle), aspirin and indomethacin were employed as negative and positive controls respectively. Eight mice were used in each experiment.
  
  
  RESULTS
  In the early phase of the formalin test, the 100mg/kg dose showed no significant antinociceptive activity while the 200mg/kg showed significant (p < 0.01) antinociceptive activity. The 100 mg/kg dose showed highly significant antinociceptive activity (p < 0.001) in the late phase of the formalin test while the 200mg/kg dose showed no significant antinociceptive activity. A reduction in carragenin induced acute inflammation paw oedema was significant (p < 0.01) following administration of 100mg/kg dose but not with the 200mg/kg dose.
  
  
  CONCLUSIONS
  The present study therefore lends support to the anecdotal evidence for use of T. asiatica in the management of painful and inflammatory conditions.
authors.affiliation: University of Nairobi, Nairobi, Kenya.
authors.forename: Hellen Nyambura
authors.initials: HN
authors.lastname: Kariuki
authors.forename: Titus Ikusya
authors.initials: TI
authors.lastname: Kanui
authors.forename: Abiy
authors.initials: A
authors.lastname: Yenesew
authors.forename: Nilesh
authors.initials: N
authors.lastname: Patel
authors.forename: Paul Mungai
authors.initials: PM
authors.lastname: Mbugua
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018517:Plant Roots; D027821:Rutaceae
chemical_list: D010936:Plant Extracts
keywords: Anti-inflammatory; Antinociceptive; Toddalia asiatica; carrageenin test; formalin test; mice; root extract