title: Distinct resident and recirculating memory T cell subsets in non-lymphoid tissues.
abstract: Antigen experienced or memory T cells make a critical contribution to immunity against infection. Many pathogens colonise non-lymphoid tissues and memory T cells in these compartments can deal with such localised infections. Emerging data show that there are at least two phenotypically distinct peripheral T cell subsets, one permanently resident and one recirculating between tissues and blood. A full appreciation of the T cells in the non-lymphoid memory pool and their relationship to those in the circulation is an important step in understanding how to generate and exploit effective peripheral immunity for the purpose of infection control.
authors.affiliation: Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia. fcarbone@unimelb.edu.au
authors.forename: Francis R
authors.initials: FR
authors.lastname: Carbone
authors.forename: Laura K
authors.initials: LK
authors.lastname: Mackay
authors.forename: William R
authors.initials: WR
authors.lastname: Heath
authors.forename: Thomas
authors.initials: T
authors.lastname: Gebhardt
mesh_terms: D000818:Animals; D002465:Cell Movement; D006801:Humans; D007156:Immunologic Memory; D008221:Lymphoid Tissue / Q000276:immunology; D010641:Phenotype; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*