title: Monocyte and macrophage heterogeneity in the heart.
abstract: Monocytes and macrophages are innate immune cells that reside and accumulate in the healthy and injured heart. The cells and their subsets pursue distinct functions in steady-state and disease, and their tenure may range between hours and months. Some subsets are highly inflammatory, whereas others support tissue repair. This review discusses current concepts of lineage relationships and crosstalk of systems, highlights open questions, and describes tools for studying monocyte and macrophage subsets in the murine and human heart.
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. mnahrendorf@mgh.harvard.edu
authors.forename: Matthias
authors.initials: M
authors.lastname: Nahrendorf
authors.forename: Filip K
authors.initials: FK
authors.lastname: Swirski
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D019070:Cell Lineage; D006333:Heart Failure / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D009203:Myocardial Infarction / Q000276:immunology* / Q000473:pathology; D009206:Myocardium / Q000276:immunology* / Q000473:pathology; D012038:Regeneration; D015398:Signal Transduction; D014945:Wound Healing
chemical_list: D015415:Biomarkers
keywords: healing; heart failure; macrophages; monocytes; myocardial infarction