title: Development of psoriasis in a patient with chronic myelogenous leukaemia during nilotinib treatment.
abstract: The tyrosine kinase inhibitor (TKI) imatinib has been shown to promote psoriasis in some patients with chronic myelogenous leukaemia (CML), but it remained unclear whether second-generation TKIs such as nilotinib and dasatinib had a similar potential. Here, we present a patient in whom psoriatic erythema appeared at 26 months after initiation of nilotinib treatment. Topical ointments of activated vitamin D3 derivative and corticosteroid were applied; whereupon, the erythema gradually improved. During the clinical course, nilotinib administration continued without reduction in its dose. This is the first report of psoriasis that developed during nilotinib treatment. We also discuss the mechanisms of nilotinib-mediated progression of psoriasis.
authors.affiliation: Division of Hematology, Jichi Medical University, Tochigi, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nagai
authors.affiliation: Department of Dermatology, Jichi Medical University, Tochigi, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Karakawa
authors.affiliation: Department of Dermatology, Jichi Medical University, Tochigi, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Komine
authors.affiliation: Division of Cell Transplantation and Transfusion, Jichi Medical University, Tochigi, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Muroi
authors.affiliation: Department of Dermatology, Jichi Medical University, Tochigi, Japan.
authors.forename: Mamitaro
authors.initials: M
authors.lastname: Ohtsuki
authors.affiliation: Division of Hematology, Jichi Medical University, Tochigi, Japan.
authors.forename: Keiya
authors.initials: K
authors.lastname: Ozawa
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy; D008297:Male; D047428:Protein Kinase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D011565:Psoriasis / Q000175:diagnosis / Q000209:etiology*; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D012867:Skin / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; C498826:nilotinib
keywords: chronic myelogenous leukaemia; nilotinib; psoriasis; tyrosine kinase inhibitor