title: Correlation between levels of circulating adipokines and adiponectin/resistin index with carotid intima-media thickness in hypertensive type 2 diabetic patients.
abstract: BACKGROUND
  Hypoadiponectinemia and hyperresistinemia are associated with cardiovascular disease. The increase in the carotid intima-media thickness (CIMT) assessed by B-mode ultrasound has been directly associated with increased risk of myocardial infarction and stroke.
  
  
  OBJECTIVE
  To evaluate the correlation between adipokine levels with CIMT in hypertensive type 2 diabetic patients.
  
  
  METHODS
  Serum levels of adiponectin and resistin levels were measured by ELISA in 30 type 2 diabetic patients with never-treated hypertension and in age-matched healthy controls. The CIMT (B-mode color imaging of extracranial carotid arteries using high-resolution ultrasound) was also obtained. The relationship between adipokine levels and the adiponectin/resistin index with the CIMT was assessed by the Pearson correlation coefficient test.
  
  
  RESULTS
  Adiponectin was lower (p < 0.05), and resistin higher (p < 0.01) in patients than in controls, CIMT correlated positively with resistin (R = 0.45, p < 0.02) and the adiponectin/resistin index (R = 0.58, p < 0.001), but not with adiponectin levels (r = -0.11, p > 0.1) in patients. Whereas only adiponectin levels correlated - negatively - with CIMT (r = -0.39, p < 0.02) in controls.
  
  
  CONCLUSIONS
  Our results shown that the adiponectin/resistin index seems to be more strongly associated with atherosclerosis than adipokine levels, and may be used as a reliable marker of cardiovascular risk in type 2 diabetic hypertensive patients.
authors.affiliation: Hospital General de Ticomán, Monterrey, Mexico. clinhta@hotmail.com
authors.forename: Alberto F
authors.initials: AF
authors.lastname: Rubio-Guerra
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Cabrera-Miranda
authors.forename: Hilda
authors.initials: H
authors.lastname: Vargas-Robles
authors.forename: Alberto
authors.initials: A
authors.lastname: Maceda-Serrano
authors.forename: José J
authors.initials: JJ
authors.lastname: Lozano-Nuevo
authors.forename: Bruno A
authors.initials: BA
authors.lastname: Escalante-Acosta
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D059168:Carotid Intima-Media Thickness; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D052243:Resistin / Q000097:blood*
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D052243:Resistin