title: Retrograde traffic from the Golgi to the endoplasmic reticulum.
abstract: Proteins to be secreted are transported from the endoplasmic reticulum (ER) to the Golgi apparatus. The transport of these proteins requires the localization and activity of proteins that create ER exit sites, coat proteins to collect cargo and to reshape the membrane into a transport container, and address labels--SNARE proteins--to target the vesicles specifically to the Golgi apparatus. In addition some proteins may need export chaperones or export receptors to enable their exit into transport vesicles. ER export factors, SNAREs, and misfolded Golgi-resident proteins must all be retrieved from the Golgi to the ER again. This retrieval is also part of the organellar homeostasis pathway essential to maintaining the identity of the ER and of the Golgi apparatus. In this review, I will discuss the different processes in retrograde transport from the Golgi to the ER and highlight the mechanistic insights we have obtained in the last couple of years.
authors.affiliation: University of Basel, Biozentrum, Growth & Development, Klingelbergstrasse 70, 4056 Basel, Switzerland. anne.spang@unibas.ch
authors.forename: Anne
authors.initials: A
authors.lastname: Spang
mesh_terms: D001692:Biological Transport / Q000502:physiology; D022181:COP-Coated Vesicles / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D008561:Membrane Fusion / Q000502:physiology; D059748:Proteolysis; D050600:SNARE Proteins / Q000378:metabolism*
chemical_list: D050600:SNARE Proteins