title: Trichomoniasis--an important cofactor of human immunodeficiency virus infection.
abstract: Trichomonas (T.) vaginalis is the most common non-viral sexually transmitted infection worldwide. The estimated number of new T. vaginalis infections accounts for 276.4 million cases globally. The pathogen induces local inflammation of the lower genitourinary tract, can be involved in premature labour, low birth weight and facilitates HIV-1 transmission via sexual intercourse. In the paper, we present basic epidemiological data on T. vaginalis infection, biologic mechanisms by which the pathogen enhances HIV-1 acquisition, principles of modern diagnosis and treatment of the infection.
authors.affiliation: Department of Dermatology and Venereology, Medical University of Bialystok, Poland. agabser@umb.edu.pl
authors.forename: Agnieszka Beata
authors.initials: AB
authors.lastname: Serwin
authors.forename: Marta
authors.initials: M
authors.lastname: Koper
mesh_terms: D000981:Antiprotozoal Agents / Q000627:therapeutic use; D015984:Causality; D015897:Comorbidity; D005260:Female; D014943:Global Health; D006679:HIV Seropositivity / Q000175:diagnosis* / Q000453:epidemiology* / Q000635:transmission; D006293:Health Promotion / Q000458:organization & administration; D006801:Humans; D008297:Male; D012307:Risk Factors; D012725:Sexual Behavior / Q000706:statistics & numerical data; D014245:Trichomonas Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D014246:Trichomonas vaginalis / Q000302:isolation & purification / Q000472:pathogenicity*
chemical_list: D000981:Antiprotozoal Agents