title: Manganese-catalyzed aerobic dehydrogenative cyclization toward ring-fused indole skeletons.
abstract: We describe the first example of manganese(III)-catalyzed aerobic dehydrogenative cyclization producing ring-fused indole skeletons. This catalytic system converts from two C-H bonds of indole and malonate to a C-C bond and produces water as the sole side product. This operationally easy method was extended to an intermolecular cross-dehydrogenative coupling of indole and α-substituted malonate with complete C2-selectivity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. kanai@mol.f.u-tokyo.ac.jp
authors.forename: Kounosuke
authors.initials: K
authors.lastname: Oisaki
authors.forename: Junpei
authors.initials: J
authors.lastname: Abe
authors.forename: Motomu
authors.initials: M
authors.lastname: Kanai
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006865:Hydrogenation; D007211:Indoles / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*
chemical_list: D007211:Indoles; D008345:Manganese; D010100:Oxygen