title: Detection of Candida albicans by using a designed fluorescence-quenched peptide.
abstract: Convenient detection of Candida albicans in human bodies is essential to treat patients with candidiasis. In this study, we designed a fluorescence-quenched peptide that emits fluorescence after being cleaved by virulent proteases secreted by C. albicans. The designed peptide will enable easy detection of candidiasis in immunocompromised patients.
authors.affiliation: The Japan Society for the Promotion of Science, Sakyo-ku, Kyoto 606-8502, Japan; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Aoki
authors.forename: Nao
authors.initials: N
authors.lastname: Kitahara
authors.forename: Aika
authors.initials: A
authors.lastname: Fujita
authors.forename: Seiji
authors.initials: S
authors.lastname: Shibasaki
authors.forename: Hironobu
authors.initials: H
authors.lastname: Morisaka
authors.forename: Kouichi
authors.initials: K
authors.lastname: Kuroda
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Ueda
mesh_terms: D057055:Aspartic Acid Proteases / Q000378:metabolism; D002176:Candida albicans / Q000201:enzymology / Q000302:isolation & purification* / Q000472:pathogenicity; D002177:Candidiasis / Q000175:diagnosis* / Q000382:microbiology*; D005453:Fluorescence; D006801:Humans; D010455:Peptides / Q000032:analysis* / Q000737:chemistry
chemical_list: D010455:Peptides; D057055:Aspartic Acid Proteases
keywords: Candida albicans; Candidiasis; Diagnosis; Fluorescence-quenched peptide; Secreted aspartic protease