title: Measurement of anesthetic uptake kinetics in the brain using (19)F MRI and cross-correlation analysis after pulsed application.
abstract: OBJECTIVE
  We present a pilot study based on (19)F-MRI to measure fast and slow wash-in and wash-out kinetics of volatile anesthetics in pig brain.
  
  
  METHODS
  The periodic administration of anesthetics in pulsed mode is used to enhance the sensitivity of the anesthetic concentration detection by (19)F-MRI signal. Temporal correlation analysis allows mapping the kinetics time constants.
  
  
  RESULTS
  The clear correlation response to anesthetics concentration changes was found in the brain region in comparison with fatty tissues.
  
  
  CONCLUSIONS
  The methodology may yield important pharmacological findings on regional effect of the anesthetics in brain and be a step towards human studies.
authors.affiliation: Department of Radiology, Section of Medical Physics, Johannes Gutenberg University Medical Center Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany, terekhov@uni-mainz.de.
authors.forename: Maxim
authors.initials: M
authors.lastname: Terekhov
authors.forename: Alexander
authors.initials: A
authors.lastname: Scholz
authors.forename: Laura M
authors.initials: LM
authors.lastname: Schreiber
mesh_terms: D000777:Anesthetics / Q000493:pharmacokinetics*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005461:Fluorine / Q000737:chemistry*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007554:Isotopes; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009991:Oscillometry; D010865:Pilot Projects; D013552:Swine; D013997:Time Factors
chemical_list: D000777:Anesthetics; D007554:Isotopes; D005461:Fluorine