title: Ewing's sarcoma of the larynx. Effective treatment with organ preservation.
abstract: Extraskeletal Ewing's sarcoma arising in the head and neck region is an extremely rare malignant neoplasm. We describe the unusual case of a tumor originating in the larynx of a 68-year-old male with hoarseness and occasional aphonia. We report successful treatment with sequential chemo- and radiotherapy. Complete regression and larynx preservation with voice function recovery was achieved. To our knowledge, this is the first report of this type of tumor in the larynx with cartilage invasion that documents the effectiveness of radiotherapy as an alternative to surgical management. At present, after 30 months of follow-up, the patient is free of tumor relapse and in very good condition.
authors.affiliation: Department of Radiation and Clinical Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Ul. Wybrzeże Armii Krajowej 15, 44-101, Gliwice, Poland. awygoda@poczta.onet.pl
authors.forename: A
authors.initials: A
authors.lastname: Wygoda
authors.forename: T
authors.initials: T
authors.lastname: Rutkowski
authors.forename: D
authors.initials: D
authors.lastname: Ponikiewska
authors.forename: B
authors.initials: B
authors.lastname: Hejduk
authors.forename: K
authors.initials: K
authors.lastname: Składowski
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001044:Aphonia / Q000209:etiology; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D006685:Hoarseness / Q000209:etiology; D006801:Humans; D007817:Laryngeal Cartilages / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D007828:Laryngoscopy; D007830:Larynx / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D059351:Organ Sparing Treatments / Q000379:methods*; D049268:Positron-Emission Tomography; D012512:Sarcoma, Ewing / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D014057:Tomography, X-Ray Computed; D014827:Vocal Cords / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor