title: Extending the convergence of canonical WNT signaling and classic cancer pathways for treatment of malignant peripheral nerve sheath tumors.
abstract: Malignant peripheral nerve sheath tumors (MPNST) are incurable tumors of the Schwann cell lineage that progress unpredictably from benign plexiform neurofibromas. In this issue of Cancer Discovery, Watson and colleagues use an insertional mutagenesis screen combined with network analysis to identify the canonical WNT signaling pathway as an important potential biomarker of tumor progression and target for combination therapy in MPNSTs.
authors.affiliation: Mouse Cancer Genetics Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. ReillyK@mail.nih.gov
authors.forename: Karlyne M
authors.initials: KM
authors.lastname: Reilly
mesh_terms: D006801:Humans; D018317:Nerve Sheath Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D012583:Schwann Cells / Q000378:metabolism; D060449:Wnt Signaling Pathway