title: Mortality and causes of death in Crohn's disease: results from 20 years of follow-up in the IBSEN study.
abstract: OBJECTIVE
  Population-based studies have shown a slightly decreased life expectancy in patients with Crohn's disease (CD). The primary aim of the present study was to evaluate mortality and causes of death 20 years after the diagnosis in a well defined population-based cohort of CD patients in Norway.
  
  
  METHODS
  The Inflammatory Bowel South-Eastern Norway study has prospectively followed all patients diagnosed with CD in the period between 1 January 1990 and 31 December 1993 in four geographically well-defined areas. All patients (n=237) were age and sex matched with 25 persons from the same county selected at random from the general population. Data on death and causes of deaths were collected from the Norwegian Causes of Death Register. All causes and cause-specific mortality (gastrointestinal cancer, cancer and heart disease) were modelled with Cox regression model stratified by matched sets. Results are expressed as HRs with 95% CIs.
  
  
  RESULTS
  There was no significant difference between CD patients and controls in overall mortality (HR=1.35, 95% CI 0.94 to 1.94, p=0.10). Furthermore, there were no marked differences in deaths from gastrointestinal cancer, other cancers or cardiovascular diseases in the CD group compared with the controls. In the CD group, 13.9% had died compared with 12.7% in the control group (p=0.578).
  
  
  CONCLUSIONS
  In our population-based inception cohort followed for 20 years, there was no increased mortality or more deaths from cancer compared with the general population.
authors.affiliation: Department of Gastroenterology, Innlandet Hospital Trust, , Gjøvik, Oppland, Norway.
authors.forename: Øistein
authors.initials: Ø
authors.lastname: Hovde
authors.forename: Iril
authors.initials: I
authors.lastname: Kempski-Monstad
authors.forename: Milada Cvancarova
authors.initials: MC
authors.lastname: Småstuen
authors.forename: Inger Camilla
authors.initials: IC
authors.lastname: Solberg
authors.forename: Magne
authors.initials: M
authors.lastname: Henriksen
authors.forename: Jørgen
authors.initials: J
authors.lastname: Jahnsen
authors.forename: Njål
authors.initials: N
authors.lastname: Stray
authors.forename: Bjørn A
authors.initials: BA
authors.lastname: Moum
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002423:Cause of Death; D003424:Crohn Disease / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries
keywords: Crohn'S Disease; Inflammatory Bowel Disorders