title: [Research progress on ebola virus glycoprotein].
abstract: Ebola virus (EBOV) causes outbreaks of a highly lethal hemorrhagic fever in humans and there are no effective therapeutic or prophylactic treatments available. The glycoprotein (GP) of EBOV is a transmembrane envelope protein known to play multiple functions including virus attachment and entry, cell rounding and cytotoxicity, down-regulation of host surface proteins, and enhancement of virus assembly and budding. GP is the primary target of protective immunity and the key target for developing neutralizing antibodies. In this paper, the research progress on genetic structure, pathogenesis and immunogenicity of EBOV GP in the last 5 years is reviewed.
authors.affiliation: School of Public Health, Taishan Medical College, Taian 271016, China. dgy153@126.com
authors.forename: Guo-Yong
authors.initials: GY
authors.lastname: Ding
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Wang
authors.forename: Lu
authors.initials: L
authors.lastname: Gao
authors.forename: Bao-Fa
authors.initials: BF
authors.lastname: Jiang
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D029043:Ebolavirus / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D019142:Hemorrhagic Fever, Ebola / Q000276:immunology / Q000821:virology*; D006801:Humans; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D019065:Virus Assembly
chemical_list: D000914:Antibodies, Viral; D006023:Glycoproteins; D014759:Viral Envelope Proteins