title: Treatment of recurrent breast cancer following breast conserving surgery.
abstract: Patients with isolated ipsilateral breast cancer recurrence face completion mastectomy in the majority of cases. Selected patients may derive good outcomes from repeat breast conservation surgery and indeed repeat irradiation may be employed using one of many different modalities. Tumor biology rather than salvage surgery method is likely to influence outcome. Patients with isolated breast tumor recurrence are treated in the majority of cases with completion mastectomy, when for selected patients there exists little evidence that more radical surgery provides better outcomes in terms of further recurrence and overall survival, than repeated breast conserving surgery. Literature search identifying articles addressing the issue of repeat breast conserving surgery for ipsilateral breast tumor recurrence, and repeat radiotherapy(search terms include: repeat breast conserving surgery, salvage mastectomy, salvage breast conserving surgery,salvage radiotherapy, reirradiation). Thirty-five articles discussed the outcomes of repeat breast conserving surgery versus salvage mastectomy, methods of repeat breast irradiation, repeat sentinel lymph node biopsy and related factors. Repeat breast conserving surgery may represent a safe and feasible treatment method for isolated ipsilateral breast tumor recurrence.
authors.affiliation: Unit of Breast Surgery, Department of General Surgery, Norfolk & Norwich Hospital NHS Trust, Norwich, United Kingdom.
authors.forename: Amy E E
authors.initials: AE
authors.lastname: Burger
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Pain
authors.forename: Gabor
authors.initials: G
authors.lastname: Peley
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D012307:Risk Factors; D016879:Salvage Therapy; D021701:Sentinel Lymph Node Biopsy