title: Clinical evaluation of sustained-release metronidazole gel versus metronidazole solution as an intracanal medicament in abscessed primary molars.
abstract: OBJECTIVE
  To evaluate the efficacy of metronidazole gel versus metronidazole solution against Enterococcus faecalis in abscessed primary molars.
  
  
  METHODS
  A clinical trial.
  
  
  METHODS
  Twenty pulpally involved non-vital carious human primary mandibular second molars with furcal abscess were randomly allocated into two groups to evaluate the efficacy of metronidazole gel (3% w/v) and metronidazole solution (0.5% w/v) against E. faecalis. Subjects in the first experimental group were subjected to treatment with metronidazole gel (3% w/v) and subjects in the second experimental group were treated with metronidazole solution (0.5% w/v). Two microbial samples (pre-operative and post-operative samples) were obtained from the root canals of each subject from both the groups; sub cultured and efficacy of both the groups were evaluated.
  
  
  RESULTS
  Overall percentage reduction of the mean colony forming unit (CFU) count of metronidazole gel (3% w/v) group was 96.39% and metronidazole solution (0.5 % w/v) was 90.90%. Results of intergroup t test of the percentage difference of mean CFU counts between both the groups revealed a statistically highly significant difference, i.e. p value--0.008 (p < 0.01).
  
  
  CONCLUSIONS
  Metronidazole gel (3% w/v) was more effective than metronidazole solution (0.5% w/v) against E. faecalis.
authors.affiliation: Department of Pedodontics and Preventive Dentistry, JSS Dental College and Hospital, JSS University, Mysore, Karnataka, India, drmohitbhangdia@yahoo.com.
authors.forename: M B
authors.initials: MB
authors.lastname: Bhangdia
authors.forename: B
authors.initials: B
authors.lastname: Nandlal
authors.forename: G S
authors.initials: GS
authors.lastname: Vijaykumar
authors.forename: P K
authors.initials: PK
authors.lastname: Kulkarni
authors.forename: R
authors.initials: R
authors.lastname: Shanbhog
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage*; D058491:Bacterial Load / Q000187:drug effects; D002648:Child; D003692:Delayed-Action Preparations; D003786:Dental Pulp Cavity / Q000187:drug effects / Q000382:microbiology; D003790:Dental Pulp Necrosis / Q000382:microbiology / Q000628:therapy; D013293:Enterococcus faecalis / Q000187:drug effects*; D005782:Gels; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage*; D008963:Molar / Q000382:microbiology*; D010482:Periapical Abscess / Q000188:drug therapy* / Q000382:microbiology; D012388:Root Canal Irrigants / Q000008:administration & dosage*; D018915:Root Canal Preparation / Q000379:methods; D012996:Solutions; D014094:Tooth, Deciduous / Q000382:microbiology*; D016896:Treatment Outcome; D014783:Viscosity
chemical_list: D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D005782:Gels; D012388:Root Canal Irrigants; D012996:Solutions; D008795:Metronidazole