title: Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm.
abstract: Solid pseudopapillary neoplasm (SPN) is a rare and low-grade malignant pancreatic neoplasm composed of poorly cohesive monomorphic neoplastic cells forming solid and pseudopapillary structures with frequent hemorrhagic-cystic degeneration. Intraductal papillary mucinous neoplasm (IPMN) is a pancreatic exocrine tumor composed of intraductal papillary growth of mucin containing neoplastic cells in the main pancreatic duct or its major branches. In the case presented here, a 53-year-old, Japanese man was found to have multiple cystic lesions and dilatation of the main pancreatic duct in the neck of the pancreas. Histological examination revealed a main-duct and branch-duct type IPMN, of the gastric-type, involving the neck of the pancreas, associated with a 0.5 cm SPN in the caudal side of the IPMN. We diagnosed this case as synchronous SPN and IPMN. As far as we know, only one other case of synchronous SPN and IPMN has been reported. Both the present case and the previously reported case showed abnormal nuclear expression of β-catenin in SPN, whereas IPMN showed no abnormal nuclear expression. These results suggest that β-catenin abnormality is not a common pathogenetic factor of synchronous SPN and IPMN.
authors.affiliation: Department of Pathology, Tokai University School of Medicine, Isehara 259-1193, Japan. khira@is.icc.u-tokai.ac.jp
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hirabayashi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Zamboni
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ito
authors.forename: Masami
authors.initials: M
authors.lastname: Ogawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Yamashita
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakagohri
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakamura
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D021441:Carcinoma, Pancreatic Ductal / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002760:Cholangiopancreatography, Endoscopic Retrograde; D049448:Cholangiopancreatography, Magnetic Resonance; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D010180:Pancreatectomy; D010181:Pancreatic Cyst / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D013156:Splenectomy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D051176:beta Catenin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; D051176:beta Catenin
keywords: Beta-catenin; Intraductal papillary mucinous neoplasms; Pancreas; Pancreatic neoplasms; Solid pseudopapillary neoplasms; Synchronous neoplasms