title: Evaluation of serum oxidant/antioxidant balance in patients with acute stroke.
abstract: OBJECTIVE
  To investigate the alterations in the oxidant-antioxidant balance in patients with acute ischaemic stroke, and to locate any correlation between oxidant/antioxidant parameters and the National Institute of Health Stroke Scale.
  
  
  METHODS
  The case-control study was conducted at the Neurology Department of Dicle University Medical Faculty, Diyarbakir, Turkey, from June 2010 to June 2011. Blood samples were obtained from 53 patients with ischaemic stroke and 40 healthy controls without any history of ischaemic stroke or systemic disease. Venous blood was obtained within 24 hour after stroke onset. Serum malondialdehyde, total anti-oxidant capacity, paraoxanase and superoxide dismutase were measured. SPSS 11.5 used for statistical analysis.
  
  
  RESULTS
  There was no difference between the cases and the controls regarding age [64.5 +/- 15.8 and 66.3 +/- 13.9 respectively], gender [27 (51%) / 26 (49%), and 19 (48%) / 21 (52%) respectively], obesity [15(28.3%) and 13(37.5%), respectively], and hypertension [30 (56.6%) and 23 (57.5%), respectively]. The cases had higher concentrations of malondialdehyde (147.3 +/- 59.3 vs. 112.4 +/- 28.5 nmol/gr protein, p < 0.001), and superoxide dismutase (4.40 +/- 0.79 vs. 3.35 +/- 0.51, p < 0.001) compared to the controls. However, the cases had lower concentrations of paraoxanase (23.2 +/- 23.7 vs 64.7 +/- 52.6, p < 0.001), total anti-oxidant capacity (0.77 +/- 0.38 vs. 0.95 +/- 0.30, p < 0.015), and nitric oxide (10.8 +/- 7.1 vs. 17.5 +/- 2.4 micromol/gr protein, p < 0.001), compared to the controls. In the stroke group, a significant negative correlation was found between the National Institute of Health Stroke Scale and total anti-oxidant capacity activity (p < 0.021, r = -0.32).
  
  
  CONCLUSIONS
  The results support the hypothesis that sufficient anti-oxidant capacity has a beneficial effect on the clinical severity of acute ischaemic stroke.
authors.affiliation: Department of Neurology, Medical Faculty, Dicle University, Diyarbakir, Turkey. drabdullahacar@hotmail.com
authors.forename: Acar
authors.initials: A
authors.lastname: Abdullah
authors.forename: Varol
authors.initials: V
authors.lastname: Ssefer
authors.forename: Uzar
authors.initials: U
authors.lastname: Ertugrul
authors.forename: Evliyaoglu
authors.initials: E
authors.lastname: Osman
authors.forename: Akil
authors.initials: A
authors.lastname: Esref
authors.forename: Cevik Mehmet
authors.initials: CM
authors.lastname: Ugur
authors.forename: Arikanoglu
authors.initials: A
authors.lastname: Adalet
authors.forename: Yucel
authors.initials: Y
authors.lastname: Yavuz
authors.forename: Ekici
authors.initials: E
authors.lastname: Faysal
authors.forename: Tasdemir
authors.initials: T
authors.lastname: Nebahat
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D016877:Oxidants / Q000097:blood*; D020521:Stroke / Q000097:blood* / Q000201:enzymology; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D016877:Oxidants; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D043303:Aryldialkylphosphatase