title: Invasive infections caused by Streptococcus pneumoniae in a tertiary-level children's hospital before the introduction of the conjugate vaccine: clinical characteristics and serotypes involved.
abstract: Invasive pneumococcal diseases are the main cause of morbidity and mortality in children. In the Hospital "Prof. Dr. Juan P. Garrahan", between October 1st , 2008 and September 30th, 2011 all invasive pneumococcal diseases with positive blood cultures were retrospectively studied before the implementation of the universal immunization schedule with the 13-valent pneumococcal conjugate vaccine. A total of 124 patients were identified, and their mean age was 48.3 months (range: 1-216). In this population, 58.9% (n: 73) were OVER 2 years old and 89% (n: 65) of them had an underlying disease. The most frequent clinical presentation was pneumonia. The most frequent S. pneumoniae serotypes identified were: 14 (22.5%, n: 25), 6 (14.4%, n: 16), 19 (8.1%, n: 9), 23 (7.2%, n: 8), 1 (6.3%, n: 7), 5 (4.5%, n: 5), and 7 (7.2%, n: 8). Of the S. pneumoniae serotypes in this series, 82.2% is included in the 13-valent pneumococcal conjugate vaccine. Continuous epidemiological surveillance is essential to further identify the epidemiology and study the evolution of invasive pneumococcal disease in Argentina.
authors.affiliation: Servicio de Control Epidemiológico e Infectología, Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan. guaperez@hotmail.com
authors.forename: Guadalupe M
authors.initials: GM
authors.lastname: Pérez
authors.forename: Adriana
authors.initials: A
authors.lastname: Parra
authors.forename: Lidia
authors.initials: L
authors.lastname: Casimir
authors.forename: Alejandra
authors.initials: A
authors.lastname: Mastroianni
authors.forename: Vanesa
authors.initials: V
authors.lastname: Reijtman
authors.forename: Horacio
authors.initials: H
authors.lastname: Lopardo
authors.forename: Rosa
authors.initials: R
authors.lastname: Bologna
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D008297:Male; D011008:Pneumococcal Infections / Q000175:diagnosis* / Q000382:microbiology*; D022242:Pneumococcal Vaccines; D012189:Retrospective Studies; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification*; D062606:Tertiary Care Centers; D018074:Vaccines, Conjugate
chemical_list: C538862:13-valent pneumococcal vaccine; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate