title: Solajiangxins A-C, three new cytotoxic sesquiterpenoids from Solanum lyratum.
abstract: One new eudesmane-type (1, named solajiangxin A) and two new eudesmane-related sesquiterpenoids (2-3, named solajiangxins B-C) were isolated from the whole plant of Solanum lyratum. Their structures were elucidated on the basis of integrated spectroscopic techniques. In vitro, three new sesquiterpenoids were found to show significant cytotoxicities against three human cancer lines (P-388, HONE-1 and HT-29), and gave ED50 values in the range of 1.9-3.7 μg/ml.
authors.affiliation: School of Pharmaceutical Science, Yantai University, Yantai 264005, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yao
authors.forename: Qin-Lan
authors.initials: QL
authors.lastname: Song
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Gui-Sheng
authors.initials: GS
authors.lastname: Li
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Dai
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D032322:Solanum / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012717:Sesquiterpenes; C586589:solajiangxin A; C586590:solajiangxin B; C586591:solajiangxin C
keywords: Cytotoxic activity; Sesquiterpenoids; Solajiangxins A–C; Solanaceae; Solanum lyratum