title: A major response to trabectedin in metastatic malignant fibrous histiocytoma of the vertebra: a case report and review of the literature.
abstract: Malignant fibrous histiocytoma is an aggressive tumor, the most common soft-tissue sarcoma of adult age. It is usually located in the extremities and retroperitoneum, and very rarely there is skeletal involvement. Surgery is the preferred treatment in early disease; in advanced disease, chemotherapy is the main therapeutic strategy. We present a 25-year-old female patient diagnosed with a vertebral mass in T5 with a severely compromised spinal cord. She underwent surgical decompression and the pathological findings were consistent with malignant fibrous histiocytoma. After several surgical treatments she had pulmonary progression and was therefore started on chemotherapy. She had a very poor response to most of the administered regimens until she initiated trabectedin 1 mg/m 2 every three weeks. She showed a significant improvement with a major response of the lung metastases. This report indicates that trabectedin is an active drug in advanced, previously treated metastatic malignant fibrous histiocytoma.
authors.affiliation: Oncology Department, Infanta Sofía University Hospital, Madrid, Spain. mariasereno75@gmail.com
authors.forename: María
authors.initials: M
authors.lastname: Sereno
authors.forename: María
authors.initials: M
authors.lastname: Merino
authors.forename: Cristina
authors.initials: C
authors.lastname: Aguayo
authors.forename: Susana
authors.initials: S
authors.lastname: Hernández
authors.forename: Gerardo
authors.initials: G
authors.lastname: Gutiérrez-Gutiérrez
authors.forename: Francisco
authors.initials: F
authors.lastname: Zambrana Tévar
authors.forename: Miriam
authors.initials: M
authors.lastname: López-Gómez
authors.forename: César
authors.initials: C
authors.lastname: Gómez Raposo
authors.forename: Enrique
authors.initials: E
authors.lastname: Casado-Sáenz
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D004149:Dioxoles / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000737:chemistry / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008279:Magnetic Resonance Imaging; D013125:Spinal Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000188:drug therapy*; D044005:Tetrahydroisoquinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed; D000077606:Trabectedin
chemical_list: D018906:Antineoplastic Agents, Alkylating; D014408:Biomarkers, Tumor; D004149:Dioxoles; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin