title: Gadolinium-deferasirox-D-glucosamine: novel anti-tumor and MR molecular (theranostic) imaging agent.
abstract: TARGET AND PURPOSE: Cancer and heart disease are hard maladies in human communities. To recognize these kinds of diseases in primary states can help for remission and decreasing the expenses. One of the best techniques for recognizing is imaging of the tissue.
  
  
  METHODS
  The main reason of this study is to survey the design of molecules Gd3+ -Defrasirox-DG as a type of glucose labeled with gadolinium to capture more specific cancer tissue and heart by MRI instrument as a technique extremely accurate and sensitive not too costly and lack of radioactive half-life compared with radioactive 18FDG as competing compound.
  
  
  RESULTS
  In this research, glucose is combined with Deferasirox for making complexes with gadolinium. With replacing the new compound of advanced imaging technology, it transferred from nuclear medicine to Radiology and the results were evaluated in vitro and in vivo that indicated the success in imaging of the heart and cancer in animal tumor model.
  
  
  CONCLUSIONS
  The mechanism of cancer cells death is through activation of TNF-α system. At present, due to the lack of radiation and radioactive half-life and low production cost and high access to MRI compared with PET, this compound can be considered as 18FDG opponent in the near future as the new MRI successor agent.
authors.affiliation: The Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. shafieeardestani@sina.tums.ac.ir.
authors.forename: Massoud
authors.initials: M
authors.lastname: Amanlou
authors.forename: Hossein
authors.initials: H
authors.lastname: Mahian
authors.forename: Ahmad Molaei
authors.initials: AM
authors.lastname: Rad
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Delbaz
authors.forename: Seyed Esmaeil Sadat
authors.initials: SE
authors.lastname: Ebrahimi
authors.forename: Amir
authors.initials: A
authors.lastname: Javidi
authors.forename: Ali Jabbari
authors.initials: AJ
authors.lastname: Arabzadeh
authors.forename: Mehdi Shafiee
authors.initials: MS
authors.lastname: Ardestani
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001565:Benzoates / Q000737:chemistry*; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D003287:Contrast Media / Q000737:chemistry*; D000077588:Deferasirox; D004195:Disease Models, Animal; D005682:Gadolinium / Q000737:chemistry*; D005944:Glucosamine / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry; D006593:Hexokinase / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D008819:Mice, Nude; D008856:Microscopy, Fluorescence; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D010766:Phosphorylation; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000737:chemistry; D051381:Rats; D013997:Time Factors; D014230:Triazoles / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D001565:Benzoates; D003287:Contrast Media; D019275:Radiopharmaceuticals; D014230:Triazoles; D014409:Tumor Necrosis Factor-alpha; D005682:Gadolinium; D006593:Hexokinase; D005947:Glucose; D005944:Glucosamine; D000077588:Deferasirox