title: Carbon monoxide transport and actions in blood and tissues.
abstract: This chapter will discuss the transport of carbon monoxide (CO) from the environment to the tissues of the body and physiological effects on blood-borne cells and perivascular tissues. It will review the physiology of CO exchange between alveolar gas and pulmonary capillary blood, dynamics of hemoglobin transport, the effects of CO on blood elements, and the effects of CO on extravascular tissues at the capillary bed. Effects of CO from exogenous and endogenous sources on the activities of different proteins will be reviewed. Because CO binds competitively to heme-containing proteins its effects depend on CO concentration relative to alternative ligands. Therefore, some discussion is devoted to how nitric oxide and hydrogen sulfide influence CO effects.
authors.affiliation: Department of Emergency Medicine, Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. sthom@mail.med.upenn.edu
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Thom
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D001692:Biological Transport / Q000502:physiology; D001773:Blood Cells / Q000187:drug effects; D002248:Carbon Monoxide / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000502:physiology; D006420:Hemeproteins / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000378:metabolism; D008954:Models, Biological; D011659:Pulmonary Gas Exchange / Q000502:physiology
chemical_list: D006420:Hemeproteins; D002248:Carbon Monoxide