title: A palladium-catalyzed enantioselective addition of arylboronic acids to cyclic ketimines.
abstract: Sly as Nicox: A palladium-catalyzed addition of arylboronic acids to ketimines has been developed to efficiently provide products in up to 99 % yield and 96 % ee. The reactions could be run under aerobic conditions and with unpurified trifluoroethanol (TFE). A pyrrolidine compound bearing a chiral α-tertiary amine was synthesized in several steps without loss of enantioselectivity. TFA = trifluoroacetate.
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yang
authors.forename: Wanbin
authors.initials: W
authors.lastname: Zhang
keywords: amines; asymmetric catalysis; enantioselectivity; heterocycles; palladium