title: A novel liver function evaluation system using radiopharmacokinetic modeling of technetium-99m-DTPA-galactosyl human serum albumin.
abstract: BACKGROUND
  A new kinetic model of technetium-99m-labeled diethylenetriaminepentaacetic acid-galactosyl human serum albumin (Tc-GSA) was developed to show the speed of asialoglycoprotein receptor-mediated endocytosis.
  
  
  METHODS
  Ten healthy volunteers and 17 patients with liver cirrhosis were intravenously injected with 185 MBq of Tc-GSA, and dynamic planar images were acquired. The absolute amounts of Tc-GSA in the liver and extrahepatic blood were estimated from the time-activity curves for the liver, heart, and lungs. A two-compartment model was represented with two parameters as variables to estimate the uptake index (UI) of Tc-GSA transport through the hepatic cell membrane from the total plasma at any given time.
  
  
  RESULTS
  The dynamic curve of Tc-GSA uptake by the liver was generated. Analysis of individuals with normal livers and patients with liver cirrhosis showed statistically significant differences in their UI. The UI for normal livers was high and that for cirrhotic livers was low. Linear regression correlation of UI with albumin, prealbumin, and prothrombin time was 0.841, 0.746, and -0.723, respectively.
  
  
  CONCLUSIONS
  UI reflects the cellular transport of asialoglycoproteins as ascertained by the two-compartment model on the basis of GSA dynamic images. It is useful for measuring liver function.
authors.affiliation: Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences, China.
authors.forename: Shunda
authors.initials: S
authors.lastname: Du
authors.forename: Yilei
authors.initials: Y
authors.lastname: Mao
authors.forename: Junxiang
authors.initials: J
authors.lastname: Tong
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.forename: Lu
authors.initials: L
authors.lastname: Che
authors.forename: Shaohua
authors.initials: S
authors.lastname: Li
authors.forename: Huayu
authors.initials: H
authors.lastname: Yang
authors.forename: Jiantao
authors.initials: J
authors.lastname: Ba
authors.forename: Nan
authors.initials: N
authors.lastname: Hu
authors.forename: Haiqun
authors.initials: H
authors.lastname: Xing
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.forename: Xinting
authors.initials: X
authors.lastname: Sang
authors.forename: Xianzhong
authors.initials: X
authors.lastname: Zhang
authors.forename: Xuebin
authors.initials: X
authors.lastname: Wang
authors.forename: Shouxian
authors.initials: S
authors.lastname: Zhong
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D008111:Liver Function Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011877:Radionuclide Imaging; D012709:Serum Albumin / Q000737:chemistry; D013668:Technetium Tc 99m Aggregated Albumin / Q000493:pharmacokinetics*; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics*
chemical_list: D012709:Serum Albumin; D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; D016284:Technetium Tc 99m Pentetate