title: Synthesis and pharmacological activity of 1,8,11,11-tetramethyl-4-azatricyclo[5.2.2.0(2,6)]undec-8-ene-3,5-dione derivatives. [corrected].
abstract: The synthesis and pharmacological activity of N-substituted derivatives of 1,8,11,11-tetramethyl-4-azatricyclo[5.2.2.0(2,6)]undec-8-ene-3,5-dione (1) are described. The molecular structure of starting compound (1) was confirmed by elemental analysis, 13C NMR and X-ray crystallography. The structures of derivatives were confirmed by 1H NMR and mass spectra. The compounds were investigated for antibacterial activity, including Gram-positive cocci, Gram-negative rods, and antifungal activity. Studied compounds were evaluated also for their cytotoxicity and anti-HIV-1 activity in MT-4 cells.
authors.affiliation: Department of Medical Chemistry, Medical University of Warsaw, Oczki 3, 02-007 Warszawa, Poland. magdalena.pakosinska-parys@wum.edu.pl
authors.forename: Magdalena
authors.initials: M
authors.lastname: Pakosińska-Parys
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kossakowski
authors.forename: Barbara
authors.initials: B
authors.lastname: Mirosław
authors.forename: Anna E
authors.initials: AE
authors.lastname: Kozioł
authors.forename: Joanna
authors.initials: J
authors.lastname: Stefańska
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D015497:HIV-1 / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents