title: [Primary antiphospholipid syndrome: newly developed leg ulcer and history of stroke].
abstract: Antiphospholipid syndrome features not only deep vessel thrombosis but also may have cutaneous manifestations such as Raynaud phenomenon, acral necrosis, livedo reticularis, subcutaneous nodules, and leg ulcers. A 72-year-old man presented with a rapidly progressing leg ulcer. He was already on anticoagulation with warfarin due to atrial fibrillation and disclosed a history of stroke with temporary paresis of the left leg. Histopathology of a biopsy of the edge of the ulcer revealed occlusive arteriosclerosis of medium-sized arteries. Serology showed autoantibodies against cardiolipin, β2- glycoprotein I, and phosphatidylserine which led to the diagnosis of antiphospholipid syndrome. Therapy with low molecular weight heparin, dexamethasone, and azathioprine in combination with stage-adjusted wound care led to complete healing of the ulcer within 5 months.
authors.affiliation: Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.
authors.forename: N
authors.initials: N
authors.lastname: Van Beek
authors.forename: N
authors.initials: N
authors.lastname: Schumacher
authors.forename: O
authors.initials: O
authors.lastname: Haase
authors.forename: D
authors.initials: D
authors.lastname: Zillikens
authors.forename: B
authors.initials: B
authors.lastname: Kahle
authors.forename: E
authors.initials: E
authors.lastname: Schmidt
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000925:Anticoagulants / Q000627:therapeutic use*; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000628:therapy*; D001458:Bandages; D004359:Drug Therapy, Combination; D006801:Humans; D007871:Leg Ulcer / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D020521:Stroke / Q000175:diagnosis / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000925:Anticoagulants