title: Combating Helicobacter pylori infections with mucoadhesive nanoparticles loaded with Garcinia mangostana extract.
abstract: OBJECTIVE
  To combat the resistance of Helicobacter pylori to antibiotics through the use of Garcinia mangostana extract (GME) in the form that can be localized at stomach mucosa.
  
  
  METHODS
  GME and its major active component, α-mangostin, are encapsulated into the moderately acid stable mucoadhesive nanocarriers, and tested for anti-H. pylori and antiadhesion activities in vitro and their ability to eradicate H. pylori in infected mice.
  
  
  RESULTS
  The two in vitro activities are observed and are enhanced when the materials are encapsulated into nanocarriers. Preliminary in vivo tests revealed the ability to combat H. pylori in mice following oral administration of the encapsulated GME, but not the unencapsulated GME.
  
  
  CONCLUSIONS
  Nanoencapsulated GME is a potential anti-H. pylori agent.
authors.affiliation: Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Porntip
authors.initials: P
authors.lastname: Pan-in
authors.forename: Amornset
authors.initials: A
authors.lastname: Tachapruetinun
authors.forename: Nuntaree
authors.initials: N
authors.lastname: Chaichanawongsaroj
authors.forename: Wijit
authors.initials: W
authors.lastname: Banlunara
authors.forename: Sunit
authors.initials: S
authors.lastname: Suksamrarn
authors.forename: Supason
authors.initials: S
authors.lastname: Wanichwecharungruang
mesh_terms: D018829:Adhesins, Bacterial / Q000187:drug effects; D000818:Animals; D002460:Cell Line; D004337:Drug Carriers / Q000737:chemistry; D029762:Garcinia mangostana / Q000737:chemistry*; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D053758:Nanoparticles / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013270:Stomach / Q000382:microbiology; D044004:Xanthones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D018829:Adhesins, Bacterial; D004337:Drug Carriers; D010936:Plant Extracts; D044004:Xanthones; C021053:mangostin