title: Similar verbal fluency patterns in amnestic mild cognitive impairment and Alzheimer's disease.
abstract: Disproportionately greater deficits in semantic relative to phonemic verbal fluency are seen in Alzheimer's disease (AD) and have been attributed to neurodegenerative changes in the temporal lobe. Amnestic (AMN) mild cognitive impairment (MCI), which often represents incipient AD, is also characterized by early temporal lobe neuropathology, but previous comparisons of verbal fluency between AD and AMN MCI have yielded mixed results. We examined semantic and phonemic verbal fluency performance in 399 individuals (78 AD, 138 AMN MCI, 72 non-amnestic MCI, and 111 cognitively normal controls). Similar verbal fluency patterns were seen in AMN MCI and AD; both groups exhibited disproportionately poorer performance on semantic verbal fluency relative to normal controls. However, relative verbal fluency indices performed more poorly than individual semantic or phonemic verbal fluency indices for discriminating AMN MCI or AD participants from normal controls, suggesting that they are unlikely to provide additional utility for predicting progression from MCI to AD.
authors.affiliation: Neurobehavior Unit, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
authors.forename: Edmond
authors.initials: E
authors.lastname: Teng
authors.forename: Judith
authors.initials: J
authors.lastname: Leone-Friedman
authors.forename: Grace J
authors.initials: GJ
authors.lastname: Lee
authors.forename: Stephanie
authors.initials: S
authors.lastname: Woo
authors.forename: Liana G
authors.initials: LG
authors.lastname: Apostolova
authors.forename: Shelly
authors.initials: S
authors.lastname: Harrell
authors.forename: John M
authors.initials: JM
authors.lastname: Ringman
authors.forename: Po H
authors.initials: PH
authors.lastname: Lu
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000503:physiopathology*; D000647:Amnesia / Q000150:complications* / Q000503:physiopathology*; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D013064:Speech Disorders / Q000150:complications* / Q000503:physiopathology*
keywords: Alzheimer's disease; Assessment; Cognition; Dementia; Mild cognitive impairment; Verbal fluency