title: The other face of ROS: a driver of stem cell expansion in colorectal cancer.
abstract: APC mutations causing Wnt activation are commonly found in colorectal cancer, but downstream pathways that facilitate tumorigenesis are unclear. In this issue of Cell Stem Cell, Myant et al. (2013) show that Rac1 activation is required for Wnt-driven Lgr5+ intestinal stem cell transformation through ROS production and NF-kB activation.
authors.affiliation: Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy. piergiuseppe.pelicci@ieo.eu
authors.forename: Pier Giuseppe
authors.initials: PG
authors.lastname: Pelicci
authors.forename: Paola
authors.initials: P
authors.lastname: Dalton
authors.forename: Marco
authors.initials: M
authors.lastname: Giorgio
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000473:pathology*; D007421:Intestine, Small / Q000166:cytology*; D016328:NF-kappa B / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology*; D051153:Wnt Proteins / Q000378:metabolism*; D020830:rac1 GTP-Binding Protein / Q000378:metabolism*
chemical_list: D016328:NF-kappa B; D009479:Neuropeptides; C484602:Rac1 protein, mouse; D017382:Reactive Oxygen Species; D051153:Wnt Proteins; D020830:rac1 GTP-Binding Protein