title: Selective detection of sub-atto-molar Streptavidin in 10(13)-fold impure sample using photonic crystal nanolaser sensors.
abstract: Biosensors selectively detecting a very small amount of biomarker protein in human blood are desired for early and reliable diagnoses of severe diseases. This paper reports the detection of protein (streptavidin: SA) in ultra-low concentration, with an ultra-high selectivity against contaminants, using photonic crystal nanolasers. For biotin-modified nanolasers in pure water with SA, an extremely-low detection limit of 16 zM is evaluated. Even in a mixture with 1 μM bovine serum albumin as the contaminant, 100 zM SA is detected, meaning a selectivity of 10(13). These are remarkable capabilities that are promising for practical biosensing in the medical applications mentioned above.
authors.affiliation: Department of Electrical and Computer Engineering, Yokohama National University 79-5 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan. Shoji-hachuda-dc@ynu.ac.jp
authors.forename: Shoji
authors.initials: S
authors.lastname: Hachuda
authors.forename: Shota
authors.initials: S
authors.lastname: Otsuka
authors.forename: Shota
authors.initials: S
authors.lastname: Kita
authors.forename: Toshinari
authors.initials: T
authors.lastname: Isono
authors.forename: Michimasa
authors.initials: M
authors.lastname: Narimatsu
authors.forename: Keisuke
authors.initials: K
authors.lastname: Watanabe
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Goshima
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Baba
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D003460:Crystallization; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007834:Lasers; D036103:Nanotechnology / Q000295:instrumentation*; D010783:Photometry / Q000295:instrumentation*; D012031:Refractometry / Q000295:instrumentation*; D012680:Sensitivity and Specificity; D019809:Streptavidin / Q000097:blood*
chemical_list: D019809:Streptavidin