title: Larynx preservation: what is the best non-surgical strategy?
abstract: The concept of larynx preservation in locally advanced laryngeal or hypopharyngeal squamous cell carcinoma has evolved during the last three decades, especially with the advancement of nonsurgical strategies. These nonsurgical strategies include: (1) radiotherapy alone; (2) concomitant chemoradiotherapy (CCRT); and (3) induction chemotherapy followed by radiotherapy or CCRT and concurrent anti-epidermal growth factor receptor (EGFR). To date, the best approach for larynx preservation has yet to be defined. In this article, we review and discuss important recent randomized phase II/III trials investigating larynx preservation in order to facilitate the selection of an appropriate strategy in the clinical setting. However, the decision of larynx preservation should always be a multidisciplinary approach.
authors.affiliation: Department of Medical Oncology, Salah Azaiez Institute, Tunis, Tunisia. Electronic address: aymen.lagha@hotmail.com.
authors.forename: Aymen
authors.initials: A
authors.lastname: Lagha
authors.forename: Nesrine
authors.initials: N
authors.lastname: Chraiet
authors.forename: Soumaya
authors.initials: S
authors.lastname: Labidi
authors.forename: Hela
authors.initials: H
authors.lastname: Rifi
authors.forename: Mouna
authors.initials: M
authors.lastname: Ayadi
authors.forename: Sarra
authors.initials: S
authors.lastname: Krimi
authors.forename: Bassem
authors.initials: B
authors.lastname: Allani
authors.forename: Henda
authors.initials: H
authors.lastname: Raies
authors.forename: Slim
authors.initials: S
authors.lastname: Touati
authors.forename: Hamouda
authors.initials: H
authors.lastname: Boussen
authors.forename: Lotfi
authors.initials: L
authors.lastname: Kochbati
authors.forename: Amel
authors.initials: A
authors.lastname: Mezlini
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D059248:Chemoradiotherapy; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D003131:Combined Modality Therapy; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D009367:Neoplasm Staging; D011878:Radiotherapy; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
keywords: Concomitant; Induction chemotherapy; Larynx preservation; Radiotherapy; Targeted therapy