title: Association between HLA-G 14-bp insertion/deletion polymorphism and hepatocellular carcinoma in Korean patients with chronic hepatitis B viral infection.
abstract: OBJECTIVE
  The aim of this study was to determine whether the major HLA-G gene was associated with hepatocellular carcinoma (HCC). Abnormal HLA-G expression is present in various diseases, such as renal cell carcinoma, asthma and classical Hodgkin's lymphoma.
  
  
  METHODS
  To investigate the possible association with susceptibility to HCC, 181 chronic hepatitis patients and 180 HCC patients were enrolled in this study. The HLA-G 14-bp insertion/deletion polymorphism is located in the 3' untranslated region of the HLA-G gene and was analyzed using polymerase chain reaction. For analysis of genetic data, SNPStats and SPSS 18.0 were used. Logistic regression models were performed to determine the odds ratio, 95% confidence interval, and p value.
  
  
  RESULTS
  Allele and genotype frequencies of the HLA-G 14-bp insertion/deletion polymorphism in the hepatitis group had a similar pattern, as compared to those in the HCC group. Furthermore, no differences were observed between patients with and without liver cirrhosis.
  
  
  CONCLUSIONS
  These results suggest that the HLA-G 14-bp insertion/deletion polymorphism may not be associated with HCC susceptibility and liver cirrhosis development in the Korean population.
authors.affiliation: Kohwang Medical Research Institute, Kyung Hee University, Seoul, Korea.
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Jeon
authors.forename: Jae Jun
authors.initials: JJ
authors.lastname: Park
authors.forename: Jae Myung
authors.initials: JM
authors.lastname: Cha
authors.forename: Kwang Ro
authors.initials: KR
authors.lastname: Joo
authors.forename: Joung Il
authors.initials: JI
authors.lastname: Lee
authors.forename: Hyun Phil
authors.initials: HP
authors.lastname: Shin
mesh_terms: D000483:Alleles; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000821:virology*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D059951:HLA-G Antigens / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D054643:INDEL Mutation; D008103:Liver Cirrhosis / Q000235:genetics* / Q000821:virology*; D008113:Liver Neoplasms / Q000235:genetics* / Q000821:virology*; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea
chemical_list: D059951:HLA-G Antigens