title: The immunological identity of tumor: Self implications.
abstract: By means of well-characterized autoimmunity models, we comparatively probed the "selfness" of malignant cells and their normal counterparts. We found that tumors activate self-tolerance mechanisms much more efficiently than normal tissues, reflecting a status of immunoprivileged "self." Our findings indicate that potent autoimmune responses can eradicate established malignancies, yet the collateral destruction of healthy tissues may prove difficult to circumvent.
authors.affiliation: Department of Microbiology & Immunology; University of Miami Miller School of Medicine; Miami, FL USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Miska
authors.forename: Priyadharshini
authors.initials: P
authors.lastname: Devarajan
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Chen
keywords: altered self; autoimmunity; cancer; immunoprivileged self; regulatory T cell (Treg)