title: The prevention of canine leishmaniasis and its impact on public health.
abstract: Canine leishmaniasis (CanL) caused by Leishmania infantum is a vector-borne disease of great veterinary and medical significance. Prevention of CanL requires a combined approach including measures focused on dogs and the environment where the vectors perpetuate. Over past decades, considerable effort has been put towards developing novel and cost-effective strategies against CanL. Vaccination is considered among the most promising tools for controlling CanL, and synthetic pyrethroids are useful and cost-effective in reducing risk of L. infantum infection in dogs. The effectiveness of the use of vaccines plus repellents in preventing L. infantum infection and subsequent disease development should be assessed by means of large-scale, randomized controlled field trials because this combined strategy may become the next frontier in the control of CanL.
authors.affiliation: Department of Veterinary Medicine, University of Bari, 70010 Valenzano, Bari, Italy. domenico.otranto@uniba.it
authors.forename: Domenico
authors.initials: D
authors.lastname: Otranto
authors.forename: Filipe
authors.initials: F
authors.lastname: Dantas-Torres
mesh_terms: D000818:Animals; D003362:Cost-Benefit Analysis; D004283:Dog Diseases / Q000188:drug therapy / Q000517:prevention & control* / Q000635:transmission; D004285:Dogs; D004777:Environment; D006801:Humans; D007302:Insect Repellents / Q000008:administration & dosage / Q000191:economics; D007303:Insect Vectors / Q000469:parasitology; D007306:Insecticides / Q000008:administration & dosage* / Q000191:economics; D018314:Leishmania infantum / Q000276:immunology* / Q000502:physiology; D054332:Leishmaniasis Vaccines / Q000008:administration & dosage* / Q000191:economics; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary*; D011576:Psychodidae / Q000469:parasitology; D011634:Public Health; D011722:Pyrethrins / Q000008:administration & dosage* / Q000191:economics; D014611:Vaccination / Q000191:economics / Q000662:veterinary; D015047:Zoonoses / Q000469:parasitology / Q000517:prevention & control
chemical_list: D007302:Insect Repellents; D007306:Insecticides; D054332:Leishmaniasis Vaccines; D011722:Pyrethrins