title: Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century.
abstract: Vaccines, like drugs and medical procedures, are increasingly amenable to individualization or personalization, often based on novel data resulting from high throughput "omics" technologies. As a result of these technologies, 21st century vaccinology will increasingly see the abandonment of a "one size fits all" approach to vaccine dosing and delivery, as well as the abandonment of the empiric "isolate-inactivate-inject" paradigm for vaccine development. In this review, we discuss the immune response network theory and its application to the new field of vaccinomics and adversomics, and illustrate how vaccinomics can lead to new vaccine candidates, new understandings of how vaccines stimulate immune responses, new biomarkers for vaccine response, and facilitate the understanding of what genetic and other factors might be responsible for rare side effects due to vaccines. Perhaps most exciting will be the ability, at a systems biology level, to integrate increasingly complex high throughput data into descriptive and predictive equations for immune responses to vaccines. Herein, we discuss the above with a view toward the future of vaccinology.
authors.affiliation: Mayo Clinic Vaccine Research Group, Rochester, MN 55905, USA. Poland.gregory@mayo.edu
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Poland
authors.forename: Richard B
authors.initials: RB
authors.lastname: Kennedy
authors.forename: Brett A
authors.initials: BA
authors.lastname: McKinney
authors.forename: Inna G
authors.initials: IG
authors.lastname: Ovsyannikova
authors.forename: Nathaniel D
authors.initials: ND
authors.lastname: Lambert
authors.forename: Robert M
authors.initials: RM
authors.lastname: Jacobson
authors.forename: Ann L
authors.initials: AL
authors.lastname: Oberg
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D064420:Drug-Related Side Effects and Adverse Reactions / Q000517:prevention & control*; D057166:High-Throughput Screening Assays; D006801:Humans; D057285:Precision Medicine; D049490:Systems Biology / Q000639:trends; D014612:Vaccines
chemical_list: D014612:Vaccines
keywords: Adaptive immunity; Adversomics; Biotechnology; Computational biology; Genomics; Immune response network theory; Immunogenetics; Individualized medicine; Individualized vaccinology; Modeling; Predictive equation; Proteomics; Systems biology; Vaccination; Vaccines; Vaccinomics