title: An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo.
abstract: Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting a prolonged half-life and enhanced efficacy. The use of this enzyme to treat different tumor lines both inhibited cell proliferation and impaired cellular migration in vitro and in vivo. Our data reinforce the hypothesis that nutritional depletion is a key strategy for cancer treatment.
authors.affiliation: Department of Biology, Liaoning Medical University, Jinzhou 121001, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Bi
authors.initials: B
authors.lastname: Cheng
authors.forename: Jiehua
authors.initials: J
authors.lastname: Hu
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Zhou
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
authors.forename: Liucun
authors.initials: L
authors.lastname: Gao
authors.forename: Xifan
authors.initials: X
authors.lastname: Mei
authors.forename: Meiyan
authors.initials: M
authors.lastname: Sun
authors.forename: Zhuomei
authors.initials: Z
authors.lastname: Zhang
authors.forename: Haifeng
authors.initials: H
authors.lastname: Song