title: Stable experimental model of carotid artery saccular aneurysm in swine using the internal jugular vein.
abstract: OBJECTIVE
  To develop an experimental model of stable saccular aneurysm in carotid of pigs using the internal jugular vein.
  
  
  METHODS
  In 12 healthy pigs, weighing between 25 and 5 0kg, five males and seven females, we made a right common carotid artery aneurysm. After elliptical arteriotomy, we carried out a terminolateral anastomosis with the distal stump of the internal jugular vein. Aneurysm volume was calculated so that the value did not exceed 27 times the area of the arteriotomy. After six days angiography and microscopic examination were performed to assess patency of the aneurysm and the presence of total or partial thrombosis.
  
  
  RESULTS
  There was a significant weight gain of pigs in the time interval between the manufacture of the aneurysm and angiography (p = 0.04). Aneurysmal patency was observed in ten pigs (83%). Operative wound infections occurred in two animals (16.6%), both with early onset, three days after the making of the aneurysm. Histological analysis showed aneurysm thrombus partially occluding the light in nine pigs (75%). In these animals, it was observed that on average 9% of the aneurysmal diameter was filled with thrombi.
  
  
  CONCLUSIONS
  It was possible to develop a stable experimental model of saccular aneurysms in pig carotid artery by use of the internal jugular vein.
authors.affiliation: Surgical Clinics, Federal University of Vale do São Francisco, Petrolina, Pernambuco State, Brazil. juniormedico@yahoo.com.br
authors.forename: Severino Lourenço
authors.initials: SL
authors.lastname: da Silva
authors.forename: Guilherme Benjamin Brandão
authors.initials: GB
authors.lastname: Pitta
authors.forename: Adamastor Humberto
authors.initials: AH
authors.lastname: Pereira
authors.forename: Aldemar de Araújo
authors.initials: Ade A
authors.lastname: Castro
authors.forename: Maria Helena Tavares
authors.initials: MH
authors.lastname: de Matos
authors.forename: Fábio Duque
authors.initials: FD
authors.lastname: Silveira
authors.forename: Leonardo Torres
authors.initials: LT
authors.lastname: Magalhães
authors.forename: José Adolfo Hurt Almeida
authors.initials: JA
authors.lastname: de Moraes
authors.forename: Emmylena Karina Cordeiro
authors.initials: EK
authors.lastname: Machado
authors.forename: Carlos Wagner de Souza
authors.initials: CW
authors.lastname: Wanderley
authors.forename: Camila Meirelles de Souza
authors.initials: CM
authors.lastname: Silva
authors.forename: Luciana da Paz
authors.initials: Lda P
authors.lastname: dos Santos
authors.forename: João Nicolle Tupiná
authors.initials: JN
authors.lastname: Nogueira
mesh_terms: D000783:Aneurysm; D000818:Animals; D002340:Carotid Artery Diseases; D004195:Disease Models, Animal; D005260:Female; D007601:Jugular Veins; D008297:Male; D013552:Swine