title: In silico characterization of putative drug targets in Staphylococcus saprophyticus, causing bovine mastitis.
abstract: The bovine mastitis caused by coagulase negative staphylococci (CNS) has increased in many herds of urban and rural areas of India. Emergence of multi drug resistant bacteria has further made its management more complex and serious. Therefore, innovation of novel specific drug for the treatment of disease caused by particular organism remained to be a challenge. Hence, in the present study a bacterium was isolated from milk of the cow with bovine mastitis and was identified as S. saprophyticus, 44 pathways of S. saprophyticus retrieved (KEGG) from web server were found to be non homologous to the host Bos taurus, out of which 39 pathways were found to be in cytoplasm, 2 in cell wall and 3 in the cell membrane. The knowledge of the present study could make the drug discovery easier which have high affinity to the target site of the causative organism.
authors.affiliation: P. G. Department of Studies in Microbiology and Biotechnology Karnatak University, Dharwad -580003 Karnataka, India.
authors.forename: Pramod C
authors.initials: PC
authors.lastname: Bhasme
authors.forename: Mahantesh M
authors.initials: MM
authors.lastname: Kurjogi
authors.forename: Rajeshwari D
authors.initials: RD
authors.lastname: Sanakal
authors.forename: Rohit B
authors.initials: RB
authors.lastname: Kaliwal
authors.forename: Basappa B
authors.initials: BB
authors.lastname: Kaliwal
keywords: Bovine mastitis; Drug; KEGG; Metabolic pathway; Phylogenetic tree; S. saprophyticus