title: Beneficial effect of sesame oil on heavy metal toxicity.
abstract: Heavy metals become toxic when they are not metabolized by the body and accumulate in the soft tissue. Chelation therapy is mainly for the management of heavy metal-induced toxicity; however, it usually causes adverse effects or completely blocks the vital function of the particular metal chelated. Much attention has been paid to the development of chelating agents from natural sources to counteract lead- and iron-induced hepatic and renal damage. Sesame oil (a natural edible oil) and sesamol (an active antioxidant) are potently beneficial for treating lead- and iron-induced hepatic and renal toxicity and have no adverse effects. Sesame oil and sesamol significantly inhibit iron-induced lipid peroxidation by inhibiting the xanthine oxidase, nitric oxide, superoxide anion, and hydroxyl radical generation. In addition, sesame oil is a potent inhibitor of proinflammatory mediators, and it attenuates lead-induced hepatic damage by inhibiting nitric oxide, tumor necrosis factor-α, and interleukin-1β levels. Because metal chelating therapy is associated with adverse effects, treating heavy metal toxicity in addition with sesame oil and sesamol may be better alternatives. This review deals with the possible use and beneficial effects of sesame oil and sesamol during heavy metal toxicity treatment.
authors.affiliation: Department of Toxicology, College of Graduate Studies, Gulf Medical University, Ajman, United Arab Emirates.
authors.forename: Victor Raj Mohan
authors.initials: VR
authors.lastname: Chandrasekaran
authors.forename: Dur-Zong
authors.initials: DZ
authors.lastname: Hsu
authors.forename: Ming-Yie
authors.initials: MY
authors.lastname: Liu
mesh_terms: D052117:Benzodioxoles / Q000494:pharmacology*; D002614:Chelating Agents / Q000494:pharmacology; D000075322:Heavy Metal Poisoning; D006801:Humans; D017665:Hydroxyl Radical / Q000037:antagonists & inhibitors / Q000378:metabolism; D053583:Interleukin-1beta / Q000037:antagonists & inhibitors / Q000378:metabolism; D007501:Iron / Q000009:adverse effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D011041:Poisoning / Q000188:drug therapy*; D012715:Sesame Oil / Q000494:pharmacology*; D013481:Superoxides / Q000037:antagonists & inhibitors / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D052117:Benzodioxoles; D002614:Chelating Agents; D053583:Interleukin-1beta; D010636:Phenols; D014409:Tumor Necrosis Factor-alpha; D013481:Superoxides; D009569:Nitric Oxide; D017665:Hydroxyl Radical; D012715:Sesame Oil; C025583:sesamol; D007501:Iron; D014969:Xanthine Oxidase
keywords: iron; lead; oxidative stress; sesame oil; sesamol