title: Inhibition of Candida albicans isocitrate lyase activity by cadiolides and synoilides from the ascidian Synoicum sp.
abstract: Tris-aromatic furanones (1-4) and related bis-aromatic diesters (5 and 6) isolated from the dark red ascidian Synoicum sp., were evaluated for their inhibitory activities toward Candida albicans isocitrate lyase (ICL). These studies led to the identification of compounds 1, 3, and 4 as potent ICL inhibitors, with IC50 values of 7.62, 17.16, and 10.36 μM, respectively. Growth phenotype of ICL deletion mutants and Northern blot analysis data indicated that compound 1 inhibits the ICL expression in C. albicans under C2 carbon utilizing condition.
authors.affiliation: Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-921, Republic of Korea.
authors.forename: Chan-Hong
authors.initials: CH
authors.lastname: Ahn
authors.forename: Tae Hyung
authors.initials: TH
authors.lastname: Won
authors.forename: Heegyu
authors.initials: H
authors.lastname: Kim
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001597:Benzylidene Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects / Q000201:enzymology*; D005656:Fungal Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D001597:Benzylidene Compounds; D005656:Fungal Proteins; D010636:Phenols; D012333:RNA, Messenger; D007522:Isocitrate Lyase; D015107:4-Butyrolactone