title: Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization.
abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.
authors.affiliation: Department of Neurology, Changhua Christian Hospital, Changhua 500, Taiwan.
authors.forename: Yuh-Cherng
authors.initials: YC
authors.lastname: Guo
authors.forename: Che-Mai
authors.initials: CM
authors.lastname: Chang
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Hsu
authors.forename: Siou-Jin
authors.initials: SJ
authors.lastname: Chiu
authors.forename: Yao-Ting
authors.initials: YT
authors.lastname: Tsai
authors.forename: Yii-Her
authors.initials: YH
authors.lastname: Chou
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Hou
authors.forename: Jaw-Yan
authors.initials: JY
authors.lastname: Wang
authors.forename: Mei-Hsien
authors.initials: MH
authors.lastname: Lee
authors.forename: Ke-Li
authors.initials: KL
authors.lastname: Tsai
authors.forename: Wei-Chiao
authors.initials: WC
authors.lastname: Chang
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000494:pharmacology; D066246:ErbB Receptors / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000737:chemistry / Q000494:pharmacology*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004815:Epidermal Growth Factor; D051546:Cyclooxygenase 2; D066246:ErbB Receptors; D002118:Calcium; D007213:Indomethacin