title: [Surgery for bronchial carcinoma after treatment of a previous cancer].
abstract: BACKGROUND
  The increase in the number of cancer survivors, together with the improvement of their follow-up, lead to the frequent diagnosis of resectable non-small cell lung cancer (NSCLC) in patients with history of previous malignancy. We sought to analyse the outcomes of these patients.
  
  
  METHODS
  Patients undergoing surgical resection for NSCLC between January 1980 and December 2009 were retrospectively reviewed. For each patient, the presence of previous malignancy was noted, and classified into five groups: oro-pharyngeal cancer, lung cancer, haematopoietic malignancy, other organ malignancy, and more than two cancers.
  
  
  RESULTS
  The overall population included 5846 patients. Among them, 1243 (21%) had a history of previous malignancy, of whom 383 (31%) presented with synchronous cancer. Patients with history of previous malignancy were more often female, older, with more adenocarcinomas, more limited disease, less pneumonectomies, but higher postoperative morbidity and mortality. Overall survival was worse in patients with a history of previous malignancy than in patients without (median, 5 and 10 year: 33 months, 34.3%, 17.8% versus 47 months, 44.6%, 28.8%).
  
  
  CONCLUSIONS
  A history of previous malignancy impacted significantly the prognosis of patients operated on for limited NSCLC. However, only surgical resection led to improved long-term survival at 5 years.
authors.affiliation: Service de chirurgie thoracique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Mordant
authors.forename: P-B
authors.initials: PB
authors.lastname: Pages
authors.forename: C
authors.initials: C
authors.lastname: Foucault
authors.forename: A
authors.initials: A
authors.lastname: Badia
authors.forename: E
authors.initials: E
authors.lastname: Fabre
authors.forename: A
authors.initials: A
authors.lastname: Dujon
authors.forename: F
authors.initials: F
authors.lastname: Le Pimpec Barthes
authors.forename: M
authors.initials: M
authors.lastname: Riquet
mesh_terms: D000368:Aged; D002283:Carcinoma, Bronchogenic / Q000453:epidemiology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology / Q000601:surgery*; D011013:Pneumonectomy / Q000706:statistics & numerical data; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis; D017741:Survivors / Q000706:statistics & numerical data