title: The effect of captopril on brain apoptosis after burn injury in rats.
abstract: OBJECTIVE
  The purpose of this study was to determine the possible protective effects of captopril treatment against apoptosis in the brain induced by burn injury.
  
  
  METHODS
  Under ether anaesthesia, Wistar albino rats (200-250 g) were exposed to a 900C (burn) or 250C (sham) water bath for 10 s. The ACE group was treated with i.p. 10 mg/kg captopril immediately after burn injury and this treatment was repeated twice daily. At the end of the 24 hours, brain samples were taken. Apoptotic brain cells marked by terminal deoxynucleotidyl transferase-mediated d-UTPnick end labeling (TUNEL) were evaluated in the cerebellum and midbrain of rats.
  
  
  RESULTS
  Apoptotic cells in the cerebellum were significantly decreased after captopril treatment and found to be lower when compared to the burn group (p < 0.001). In the midbrain of rats, the numbers of TUNEL-positive cells and apoptotic bodies were significantly increased in the burn group when compared to the control group (p < 0.001). The burn-induced changes were reduced in the captopril-treated burn group (p < 0.01).
  
  
  CONCLUSIONS
  Captopril has beneficial effects in burn injury and should be assessed as a therapeutic agent in the management of this condition.
authors.affiliation: Goztepe Park Medical Hospital, Medical Genetics Laboratory, Istanbul, Turkey.
authors.forename: Ibrahim Yaman
authors.initials: IY
authors.lastname: Saglam
authors.forename: Emine Nur
authors.initials: EN
authors.lastname: Ozdamar
authors.forename: Ebru
authors.initials: E
authors.lastname: Demiralay
authors.forename: Ahmet Ozer
authors.initials: AO
authors.lastname: Sehirli
authors.forename: Goksel
authors.initials: G
authors.lastname: Sener
authors.forename: Esra
authors.initials: E
authors.lastname: Saglam
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002056:Burns / Q000188:drug therapy*; D002216:Captopril / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D002216:Captopril