title: [Primary nasal clear cell carcinoma:a case report and literature review].
abstract: OBJECTIVE
  To explore the clinical and pathological characteristics of the primary nasal-sinonasal clear cell carcinoma, and then summarize the diagnosis and treatment.
  
  
  METHODS
  The clinical, imaging and pathological data were analyzed in one patient with primary nasal-sinonasal clear cell carcinoma. The domestic and foreign related literatures from 1992 were reviewed and summarized.
  
  
  RESULTS
  In 12 cases of primary nasal-sinonasal clear cell carcinoma, 8 cases (66.7%) mainly presented with nasal bleeding, 4 cases (33.3%) with destroyed bone. CT scan showed the sheet shadow similar to soft tissue density in the nasal cavity and paranasal sinuses. Three cases (25.0%) were only treated by surgical resection, 7 cases (58.3%) were treated by surgical resection combined with radiotherapy and chemotherapy, 2 cases (16.7%) were treated by radiotherapy alone. During the 6 months to 10 years follow up, only one patient died of lung metastasis.
  
  
  CONCLUSIONS
  Primary nasal-sinonasal clear cell carcinoma is rare. Nasal bleeding is commonly one of the early symptoms. It must be differentiated from metastatic clear cell carcinoma and a variety of salivary gland tumors with clear cell in pathology. Surgery combined with radiotherapy and chemotherapy is effective treatment. Short-term prognosis is good. Endoscopic surgery can be used to the tumor with a base limited in the nasal cavity and sinuses in early time. The regular check after surgery should be taken to the patients every half a year.
authors.affiliation: Department of Otolaryngology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325000, China. blesshj3@yahoo.com.cn
authors.forename: Juan
authors.initials: J
authors.lastname: Hong
authors.forename: Yong
authors.initials: Y
authors.lastname: Bi
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Lian
authors.initials: L
authors.lastname: Fang
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology / Q000628:therapy; D000328:Adult; D006801:Humans; D008297:Male; D009296:Nasal Cavity / Q000473:pathology; D009669:Nose Neoplasms / Q000473:pathology / Q000628:therapy