title: Role of murine intestinal interleukin-1 receptor 1-expressing lymphoid tissue inducer-like cells in Salmonella infection.
abstract: Interleukin (IL)-1 signaling plays a critical role in intestinal immunology. Here, we report that the major population of intestinal lamina propria lymphocytes expressing IL-1 receptor 1 (IL-1R1) is the lymphoid tissue inducer (LTi)-like cell, a type of innate lymphoid cell. These cells are significant producers of IL-22, and this IL-22 production depends on IL-1R1 signaling. LTi-like cells are required for defense against Salmonella enterica serovar Typhimurium. Moreover, colonic LTi-like cell numbers depend on the presence of the intestinal microbiota. LTi-like cells require IL-1R1 for production of protective cytokines and confer protection in infectious colitis, and their cell numbers in the colon depend upon having a microbiome.
authors.affiliation: Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Vincent L
authors.initials: VL
authors.lastname: Chen
authors.forename: Neeraj K
authors.initials: NK
authors.lastname: Surana
authors.forename: Jinyou
authors.initials: J
authors.lastname: Duan
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Kasper
mesh_terms: D000818:Animals; D002452:Cell Count; D005786:Gene Expression Regulation / Q000276:immunology*; D007113:Immunity, Innate; D007378:Interleukins / Q000096:biosynthesis / Q000378:metabolism; D007422:Intestines / Q000276:immunology* / Q000382:microbiology; D008221:Lymphoid Tissue / Q000276:immunology*; D051379:Mice; D064307:Microbiota; D009092:Mucous Membrane / Q000276:immunology; D053573:Receptors, Interleukin-1 Type I / Q000378:metabolism*; D012480:Salmonella Infections / Q000276:immunology*; D012486:Salmonella typhimurium / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology; D016019:Survival Analysis; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology / Q000378:metabolism*
chemical_list: C583355:IL1R1 protein, mouse; D007378:Interleukins; D053573:Receptors, Interleukin-1 Type I