title: Primary hypertension in children and adolescents is an immuno-metabolic disease with hemodynamic consequences.
abstract: With the rise in obesity epidemic primary hypertension (PH) is now one of the most common chronic diseases in adolescence. In contrast to hypertensive adults, hypertensive children usually are not exposed to other comorbidities such as diabetes, chronic kidney disease and atherosclerosis. Thus, PH in children and adolescents can be treated as the early stage of development of cardiovascular disease. There is increasing amount of data indicating that PH is not only hemodynamic phenomenon but a complex syndrome involving disturbed activity of sympathetic nervous system, metabolic abnormalities and activation of innate and adaptive immune system. We discuss results of the studies on clinical, metabolic and immunological phenotype of hypertensive children, associations between metabolic and immunological abnormalities with target organ damage and results of antihypertensive treatment.
authors.affiliation: Department of Nephrology and Arterial Hypertension, The Children's Memorial Health Institute, Warsaw, Poland. m.litwin@czd.pl
authors.forename: Mieczysław
authors.initials: M
authors.lastname: Litwin
authors.forename: Jacek
authors.initials: J
authors.lastname: Michałkiewicz
authors.forename: Lidia
authors.initials: L
authors.lastname: Gackowska
mesh_terms: D000293:Adolescent; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002648:Child; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000276:immunology; D012307:Risk Factors; D013564:Sympathetic Nervous System / Q000276:immunology*
chemical_list: D000959:Antihypertensive Agents