title: Pluronic-based core/shell nanoparticles for drug delivery and diagnosis.
abstract: Pluronic-based core/shell nanoparticles (NPs) were formed using various strategies such as self-assembly and temperature induced-phase transition. To improve their functionality as a nanomedicine for diagnosis and therapy, the vesicle fusion and layer by layer approach were employed. Because of the hydrophilic nature of the Pluronic shell and the relatively small size, Pluronic-based core/shell NPs were used in order to improve their pharmacokinetic behaviors in drugs and in imaging agents. This review will introduce various types of Pluronic-based core/shell NPs according to their preparation method and formation mechanism. The focus will be on the Pluronic-based core/shell NPs for tumor targeting, stimulated release of proteins, and cancer imaging capabilities.
authors.affiliation: College of Pharmacy, Korea University, 2511 Sejongro, Sejong, 339-700, Republic of Korea.
authors.forename: Yon Woo
authors.initials: YW
authors.lastname: Jung
authors.forename: Hwanbum
authors.initials: H
authors.lastname: Lee
authors.forename: Jae Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Koo
authors.forename: Keun Sang
authors.initials: KS
authors.lastname: Oh
authors.forename: Soon Hong
authors.initials: SH
authors.lastname: Yuk
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D020442:Poloxamer / Q000737:chemistry*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D008081:Liposomes; D008823:Micelles; D011994:Recombinant Proteins; D020442:Poloxamer