title: Pixelated CdTe detectors to overcome intrinsic limitations of crystal based positron emission mammographs.
abstract: A positron emission mammograph (PEM) is an organ dedicated positron emission tomography (PET) scanner for breast cancer detection. State-of-the-art PEMs employing scintillating crystals as detection medium can provide metabolic images of the breast with significantly higher sensitivity and specificity with respect to standard whole body PET scanners. Over the past few years, crystal PEMs have dramatically increased their importance in the diagnosis and treatment of early stage breast cancer. Nevertheless, designs based on scintillators are characterized by an intrinsic deficiency of the depth of interaction (DOI) information from relatively thick crystals constraining the size of the smallest detectable tumor. This work shows how to overcome such intrinsic limitation by substituting scintillating crystals with pixelated CdTe detectors. The proposed novel design is developed within the Voxel Imaging PET (VIP) Pathfinder project and evaluated via Monte Carlo simulation. The volumetric spatial resolution of the VIP-PEM is expected to be up to 6 times better than standard commercial devices with a point spread function of 1 mm full width at half maximum (FWHM) in all directions. Pixelated CdTe detectors can also provide an energy resolution as low as 1.5% FWHM at 511 keV for a virtually pure signal with negligible contribution from scattered events.
authors.affiliation: Institut de Física d'Altes Energies (IFAE), Universitat Autónoma de Barcelona (UAB), 08193 Bellaterra (Barcelona), Spain.
authors.forename: G
authors.initials: G
authors.lastname: De Lorenzo
authors.forename: M
authors.initials: M
authors.lastname: Chmeissani
authors.forename: D
authors.initials: D
authors.lastname: Uzun
authors.forename: M
authors.initials: M
authors.lastname: Kolstein
authors.forename: I
authors.initials: I
authors.lastname: Ozsahin
authors.forename: E
authors.initials: E
authors.lastname: Mikhaylova
authors.forename: P
authors.initials: P
authors.lastname: Arce
authors.forename: M
authors.initials: M
authors.lastname: Cañadas
authors.forename: G
authors.initials: G
authors.lastname: Ariño
authors.forename: Y
authors.initials: Y
authors.lastname: Calderón
keywords: Gamma camera; PET PET/CT; Pixelated detectors and associated VLSI electronics; SPECT; Solid state detectors; X-ray mammography and scinto- and MRI-mammography; coronary CT angiography (CTA)