title: Experimental ovarian transplantation on stomach for bone repair in ovariohysterectomized rabbits.
abstract: OBJECTIVE
  To evaluate the bone repair process in ovariohysterectomized rabbit submitted to an ovarian transplant to stomach that may supplying some quantity of estrogen occurs to improve bone healing.
  
  
  METHODS
  In 20 female rabbits three holes of 1, 2 and 3mm diameter in tibial shaft were made and after that all animals received OHE through a ventral incision and they were randomly divided into two groups of ten rabbits each. In group one, animals received one of their self-ovaries that transplanted on serosal layer of stomach and group two did not receive treatment. Animals were kept during bone healing for a period of 45 days and radiological, biochemical, biomechanical and histopathological evaluation.
  
  
  RESULTS
  The tibial defects in group one healed completely after 45 days and had more callous than second group. There is significant difference between two groups after operation in 21, 28 and 35 days about estrogen, progesterone and phosphatase Alkaline. The maximum forces in group one, were significantly higher than that for the group two.
  
  
  CONCLUSIONS
  Ovarian transplantation prevents the effects of ovariohysterectomized on bone healing of rabbit tibia, suggesting that unilateral transplanted ovaries can substitute for the action of ovaries on the skeleton in ovariohysterectomized animals.
authors.affiliation: Department of Surgery, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Gholam Reza
authors.initials: GR
authors.lastname: Abedi
authors.forename: Amir
authors.initials: A
authors.lastname: Sotoudeh
authors.forename: Ali
authors.initials: A
authors.lastname: Bazzazan
authors.forename: Amin
authors.initials: A
authors.lastname: Ganjai
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D007044:Hysterectomy; D010052:Ovariectomy; D010053:Ovary / Q000637:transplantation*; D011374:Progesterone / Q000378:metabolism; D011817:Rabbits; D013270:Stomach / Q000601:surgery*; D013977:Tibia / Q000293:injuries*; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology*
chemical_list: D004967:Estrogens; D011374:Progesterone; D000469:Alkaline Phosphatase