title: [Plasma cholinesterase activity in hepatic diseases].
abstract: Plasma cholinesterase activity (ChE) may vary in some pathological circumstances. We studied the changes in activity of this enzyme according to the type of liver injury, to assess the interest of this parameter in the diagnosis of liver diseases. Our study was performed on 102 patients with different liver diseases and 53 healthy controls. The ChE activity was lower in patients compared to control group (p < 0.0001), and more pronounced in cirrhotic patients compared to those suffering from hepatitis. Elevated activities of AST, ALT, GGT and ALP and bilirubinemia, and decreased albuminemia were noted in patients compared to controls (p < 0.001). Hypoalbuminemia was significantly important in cirrhotic patients compared to those suffering from cholestasis or hepatitis. A correlation between ChE and bilirubin, albumin and serum protein was found in patients with cirrhosis or those with chronic hepatitis. A significantly lower activity of ChE was found in patients with hepatic insufficiency (HI). In case of suspicion of HI, the prescription of ChE activity could guide or confirm the diagnosis of the impairment.
authors.affiliation: Laboratoire de biochimie-toxicologie, Hôpital universitaire Fattouma Bourguiba, Monastir, Tunisie. rdmanel@yahoo.fr
authors.forename: Manel
authors.initials: M
authors.lastname: Araoud
authors.forename: Hamida
authors.initials: H
authors.lastname: Mhenni
authors.forename: Ilhem
authors.initials: I
authors.lastname: Hellara
authors.forename: Olfa
authors.initials: O
authors.lastname: Hellara
authors.forename: Fadoua
authors.initials: F
authors.lastname: Neffati
authors.forename: Wahiba
authors.initials: W
authors.lastname: Douki
authors.forename: Marwa
authors.initials: M
authors.lastname: Mili
authors.forename: Hammouda
authors.initials: H
authors.lastname: Saffar
authors.forename: Mohamed Fadhel
authors.initials: MF
authors.lastname: Najjar
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000378:metabolism; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002802:Cholinesterases / Q000097:blood*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000097:blood* / Q000201:enzymology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D013577:Syndrome
chemical_list: D000418:Albumins; D015415:Biomarkers; D002802:Cholinesterases; D001663:Bilirubin
keywords: cholestasis; cirrhosis; hepatitis; hepatocellular deficiency; plasma cholinesterase