title: Impact of vacuum-assisted closure (VAC) therapy on clinical outcomes of patients with sternal wound infections: a meta-analysis of non-randomized studies.
abstract: OBJECTIVE
  To examine the impact of VAC therapy on mortality of patients with sternal wound infections after cardiothoracic surgery.
  
  
  BACKGROUND
  Controversial results regarding mortality of patients with sternal wound infections were published.
  
  
  METHODS
  We performed a systematic search in PubMed and Scopus. Mortality was the primary outcome of the meta-analysis. Recurrences, complications and length of stay were secondary outcomes.
  
  
  RESULTS
  Twenty-two retrospective studies including 2467 patients were eligible for inclusion. Patients treated with VAC had significantly lower mortality compared to those treated without VAC [2233 patients, RR = 0.40, (95% CI 0.28, 0.57)]. This finding was consistent regardless of the study design, the exclusion of studies with positive findings, the criteria for establishment of the compared groups, the time of mortality assessment or the type of infections under study, provided that adequate data was available. VAC therapy was associated with fewer recurrences (RR = 0.34, 95% CI: 0.19-0.59). The meta-analysis did not show any difference in the length of stay (RR = -2.25, 95% CI: -7.52-3.02).
  
  
  CONCLUSIONS
  VAC therapy was associated with lower mortality than other surgical techniques in retrospective cohorts of patients with DSWIs following cardiothoracic surgery.
authors.affiliation: Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece. m.falagas@aibs.gr
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Falagas
authors.forename: Giannoula S
authors.initials: GS
authors.lastname: Tansarli
authors.forename: Anastasios
authors.initials: A
authors.lastname: Kapaskelis
authors.forename: Konstantinos Z
authors.initials: KZ
authors.lastname: Vardakas
mesh_terms: D000704:Analysis of Variance; D016206:Databases, Bibliographic; D003646:Debridement / Q000379:methods; D006801:Humans; D054843:Negative-Pressure Wound Therapy / Q000401:mortality*; D012189:Retrospective Studies; D013249:Sternum / Q000293:injuries / Q000601:surgery*; D013530:Surgical Wound Infection / Q000401:mortality / Q000601:surgery*; D016019:Survival Analysis; D035441:Thoracic Wall / Q000293:injuries / Q000601:surgery*; D016896:Treatment Outcome; D014945:Wound Healing; D014950:Wounds, Penetrating / Q000401:mortality / Q000601:surgery*