title: Length of psychiatric hospitalization is correlated with CYP2D6 functional status in inpatients with major depressive disorder.
abstract: OBJECTIVE
  This study aimed to determine the effect of the CYP2D6 genotype on the length of hospitalization stay for patients treated for major depressive disorder.
  
  
  METHODS
  A total of 149 inpatients with a diagnosis of major depressive disorder at the Institute of Living, Hartford Hospital (CT, USA), were genotyped to detect altered alleles in the CYP2D6 gene. Prospectively defined drug metabolism indices (metabolic reserve, metabolic alteration and allele alteration) were determined quantitatively and assessed for their relationship to length of hospitalization stay.
  
  
  RESULTS
  Hospital stay was significantly longer in deficient CYP2D6 metabolizers (metabolic reserve <2) compared with functional or suprafunctional metabolizers (metabolic reserve ≥2; 7.8 vs 5.7 days, respectively; p = 0.002).
  
  
  CONCLUSIONS
  CYP2D6 enzymatic functional status significantly affected length of hospital stay, perhaps due to reduced efficacy or increased side effects of the medications metabolized by the CYP2D6 isoenzyme. Functional scoring of CYP2D6 alleles may have a substantial impact on the quality of care, patient satisfaction and the economics of psychiatric treatment.
authors.affiliation: Genetics Research Center, Hartford Hospital, 67 Jefferson Street, Hartford, CT 06106, USA.
authors.forename: Gualberto
authors.initials: G
authors.lastname: Ruaño
authors.forename: Bonnie L
authors.initials: BL
authors.lastname: Szarek
authors.forename: David
authors.initials: D
authors.lastname: Villagra
authors.forename: Krystyna
authors.initials: K
authors.lastname: Gorowski
authors.forename: Mohan
authors.initials: M
authors.lastname: Kocherla
authors.forename: Richard L
authors.initials: RL
authors.lastname: Seip
authors.forename: John W
authors.initials: JW
authors.lastname: Goethe
authors.forename: Harold I
authors.initials: HI
authors.lastname: Schwartz
mesh_terms: D000483:Alleles; D015331:Cohort Studies; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics / Q000378:metabolism*; D003865:Major Depressive Disorder / Q000201:enzymology* / Q000235:genetics / Q000628:therapy*; D005260:Female; D005838:Genotype; D006778:Hospitals, Psychiatric; D006801:Humans; D007297:Inpatients; D007902:Length of Stay; D008297:Male; D011446:Prospective Studies
chemical_list: D019389:Cytochrome P-450 CYP2D6