title: A walnut-enriched diet reduces the growth of LNCaP human prostate cancer xenografts in nude mice.
abstract: It was investigated whether a standard mouse diet (AIN-76A) supplemented with walnuts reduced the establishment and growth of LNCaP human prostate cancer cells in nude (nu/nu) mice. The walnut-enriched diet reduced the number of tumors and the growth of the LNCaP xenografts; 3 of 16 (18.7%) of the walnut-fed mice developed tumors; conversely, 14 of 32 mice (44.0%) of the control diet-fed animals developed tumors. Similarly, the xenografts in the walnut-fed animals grew more slowly than those in the control diet mice. The final average tumor size in the walnut-diet animals was roughly one-fourth the average size of the prostate tumors in the mice that ate the control diet.
authors.affiliation: Department of Cellular and Structural Biology, University of Texas Health Science Center , San Antonio, Texas, USA. reiter@uthscsa.edu
authors.forename: Russel J
authors.initials: RJ
authors.lastname: Reiter
authors.forename: Dun-Xian
authors.initials: DX
authors.lastname: Tan
authors.forename: Lucien C
authors.initials: LC
authors.lastname: Manchester
authors.forename: Ahmet
authors.initials: A
authors.lastname: Korkmaz
authors.forename: Lorena
authors.initials: L
authors.lastname: Fuentes-Broto
authors.forename: W Elaine
authors.initials: WE
authors.lastname: Hardman
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Rosales-Corral
authors.forename: Wenbo
authors.initials: W
authors.lastname: Qi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D028441:F2-Isoprostanes / Q000378:metabolism; D006801:Humans; D031324:Juglans; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008819:Mice, Nude; D018384:Oxidative Stress; D008517:Phytotherapy; D028321:Plant Preparations / Q000008:administration & dosage*; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D047368:Tumor Burden; D023041:Xenograft Model Antitumor Assays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D028441:F2-Isoprostanes; D028321:Plant Preparations; D017430:Prostate-Specific Antigen