title: Thrombocytopenia as a mortality risk factor in acute respiratory failure in H1N1 influenza.
abstract: BACKGROUND
  A small proportion of patients with influenza H1N1 rapidly develop acute respiratory failure and are a problem for intensive care units (ICUs). Although certain clinical risk factors have been identified, few measurable biochemical/haematological markers able to predict poor outcome have been reported. The aims of the present report are to show which variables on and during admission are associated with increased in-hospital mortality in patients admitted to the ICU with acute respiratory failure due to H1N1 influenza.
  
  
  METHODS
  A prospective observational study at two ICUs was carried out between August 2009 and March 2011. The study period covered two waves of pandemic influenza A H1N1 in Spain. Clinical and laboratory data on and during ICU admission were recorded for the purpose of analysis.
  
  
  RESULTS
  Sixty patients with acute respiratory failure due to H1N1 influenza were admitted during the period described above; 63.3% (n = 38) were male and the mean age was 49.2 ± 14 years. Regarding comorbidities, 46.7% (n = 28) were smokers, 38% (n = 23) had hypertension, 30% (n = 18) had a body mass index (BMI) >30 kg/m2, 30% (n = 18) had chronic obstructive pulmonary disease and 26% (n = 16) had cardiac insufficiency; 16.6% (n = 10) had bacterial co-infection, 70% (n = 42) required invasive mechanical ventilation and 48.3% (n = 29) non-invasive mechanical ventilation. Mortality was 20% (n = 12). Comparing survivors with non-survivors, univariate analysis revealed significant differences in BMI, creatinine, haemoglobin, platelets, arterial pH, pCO2, and the rate of bacterial co-infection. In the multivariate analysis, only the presence of lower platelet count was statistically significant (214 ± 101 vs 113 ± 82 ×109/L; p = 0.009). Patients with thrombocytopenia showed a lower in-hospital survival rate (55%vs92.5%; Log Rank = 0.008).
  
  
  CONCLUSIONS
  Thrombocytopenia could be valuable marker of in-hospital mortality in patients with respiratory failure due to H1N1 influenza in the ICU scenario.
authors.affiliation: Hospital Universitari de Bellvitge, Intensive Care Department, IDIBELL (Institut d’InvestigacióBiomèica Bellvitge; Biomedical Investigation Institute of Bellvitge), L’Hospitalet de Llobregat, Barcelona, Spain. juancarloslopezde@hotmail.com
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Lopez-Delgado
authors.forename: Assumpta
authors.initials: A
authors.lastname: Rovira
authors.forename: Francisco
authors.initials: F
authors.lastname: Esteve
authors.forename: Nicolás
authors.initials: N
authors.lastname: Rico
authors.forename: Rafael
authors.initials: R
authors.lastname: Mañez Mendiluce
authors.forename: Josep
authors.initials: J
authors.lastname: Ballús Noguera
authors.forename: Julián
authors.initials: J
authors.lastname: Berrade
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications / Q000401:mortality*; D007362:Intensive Care Units; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000401:mortality*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000401:mortality*; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D013921:Thrombocytopenia / Q000150:complications* / Q000401:mortality