title: Nature, nurture and HIV: The effect of producer cell on viral physiology.
abstract: Macrophages and CD4-positive T lymphocytes are the major targets and producers of HIV-1. While the molecular details underlying HIV replication in macrophages and T cells become better understood, it remains unclear whether viruses produced by these target cells differ in their biological properties. Recent reports suggest that HIV virions incorporate a large number of producer cell proteins and lipids which have an effect on subsequent viral replication in newly infected cells. The identity and abundance of these incorporated factors varies between different types of producer cells, suggesting that they may influence the replication capacity and pathogenic activity of the virions produced by T cells and macrophages.
authors.affiliation: Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, George Washington University, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA. siordans@gmu.edu
authors.forename: Sergey
authors.initials: S
authors.lastname: Iordanskiy
authors.forename: Steven
authors.initials: S
authors.lastname: Santos
authors.forename: Michael
authors.initials: M
authors.lastname: Bukrinsky
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D015658:HIV Infections / Q000378:metabolism / Q000821:virology; D015497:HIV-1 / Q000378:metabolism / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000821:virology*; D014771:Virion / Q000378:metabolism; D014779:Virus Replication
keywords: HIV-1; Macrophages; T lymphocytes; Viral replication; Virion-incorporated lipids; Virion-incorporated proteins