title: Imatinib mesylate therapy in patients of chronic myeloid leukemia with Philadelphia chromosome positive: an experience from eastern India.
abstract: Imatinib inhibits constitutively active BCR-ABL tyrosine kinase of chronic myeloid leukemia (CML). In a long term study it was found superior to interferon alfa plus cytarabine for newly diagnosed CML in the chronic phase. However, till date there is no major study to evaluate eastern Indian CML patients treated with imatinib mesylate. The aim of our study was to see the efficacy, tolerability, toxicity and safety of imatinib in eastern Indian subset of CML population. The present study enrolled 831 patients with CML out of which 197 were excluded due to various reasons of noncompliance, death and not being fit to receive the drug. The rest, 634 (76% of total enrolled) were selected for the evaluation. In the beginning of the study, 603 patients were in chronic phase, 27 in accelerated phase and 4 patients in blast crisis phase. Among 634 patients, 280 patients (44%) received previously either interferon alpha or hydroxyurea and other 354 patients (56%) were previously untreated. Complete hematological remission and major cytogenetic response were 91 and 67%, respectively after 1 year of treatment. Complete molecular remission was 35% after 1 year of treatment. Sixty-four patients (10.1%) were resistant to imatinib mesylate in 5 years. The disease free and overall survival at 60 months were 72.2 and 76.1% respectively. After 60 months of follow up, continuous treatment of chronic phase CML with imatinib as initial therapy was found to be safe and able to induce durable responses in a high proportion of patients.
authors.affiliation: Department of Haemato Oncology, Netaji Subhas Chandra Bose Cancer Research Institute, 16 A Park Lane, Kolkata-16 Kolkata, India.
authors.forename: A
authors.initials: A
authors.lastname: Mukhopadhyay
authors.forename: S
authors.initials: S
authors.lastname: Dasgupta
authors.forename: S
authors.initials: S
authors.lastname: Mukhopadhyay
authors.forename: C K
authors.initials: CK
authors.lastname: Bose
authors.forename: S
authors.initials: S
authors.lastname: Sarkar
authors.forename: F
authors.initials: F
authors.lastname: Gharami
authors.forename: S
authors.initials: S
authors.lastname: Koner
authors.forename: J
authors.initials: J
authors.lastname: Basak
authors.forename: U K
authors.initials: UK
authors.lastname: Roy
keywords: BCR-ABL transcript; Blood Transfusion Medicine; Chronic myeloid leukemia; Hematology; Human Genetics; Imatinib; Medicine & Public Health; Oncology; Tyrosin kinase