title: YAP forces fibroblasts to feel the tension.
abstract: Cancer-associated fibroblasts (CAFs) may contribute to tissue tension and cancer progression by increasing extracellular matrix (ECM) deposition and remodelling. However, how CAFs become activated and their roles in tumour mechanics have remained unclear. YAP is now identified as a tension-stimulated CAF activator that promotes malignancy through a mechanically reinforced feed-forward loop.
authors.forename: Ori
authors.initials: O
authors.lastname: Maller
authors.forename: Christopher C
authors.initials: CC
authors.lastname: DuFort
authors.forename: Valerie M
authors.initials: VM
authors.lastname: Weaver
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D018797:Cell Cycle Proteins; D005260:Female; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D040542:Mechanotransduction, Cellular; D010750:Phosphoproteins / Q000378:metabolism*; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; D010750:Phosphoproteins; D000091102:YAP-Signaling Proteins; C486223:Yap1 protein, mouse