title: High expression of Musashi-2 indicates poor prognosis in adult B-cell acute lymphoblastic leukemia.
abstract: Musashi-2 (MSI2) expression of 116 adult B-cells acute lymphoblastic leukemia (B-ALL) patients was measured by real-time PCR. Kaplan-Meier analysis showed that patients with high MSI2 expression had inferior overall survival (OS) (P=0.004), event free survival (EFS) (P=0.001) and relapse free survival (RFS) (P=0.018) in BCR-ABL-negative B-ALL. Multivariate models revealed that, besides WBC more than 30×10(9)/L and IK6 variant of IKZF1, high MSI2 expression was also an independent prognostic factor for adult BCR-ABL-negative B-ALL. Our data suggest that high MSI2 expression could indicate poor prognosis and facilitate risk and treatment stratification in adult BCR-ABL-negative B-ALL.
authors.affiliation: Department of Hematology, Institute of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China.
authors.forename: Qitian
authors.initials: Q
authors.lastname: Mu
authors.forename: Yungui
authors.initials: Y
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
authors.forename: Wenbin
authors.initials: W
authors.lastname: Qian
authors.forename: Haitao
authors.initials: H
authors.lastname: Meng
authors.forename: Hongyan
authors.initials: H
authors.lastname: Tong
authors.forename: Feifei
authors.initials: F
authors.lastname: Chen
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Ma
authors.forename: Wanmao
authors.initials: W
authors.lastname: Ni
authors.forename: Saijuan
authors.initials: S
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Jin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000378:metabolism* / Q000473:pathology; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D016601:RNA-Binding Proteins / Q000235:genetics*; D012194:RNA-Directed DNA Polymerase; D055815:Young Adult
chemical_list: C438151:MSI2 protein, human; D016601:RNA-Binding Proteins; D016044:Fusion Proteins, bcr-abl; D012194:RNA-Directed DNA Polymerase