title: First description of KPC-2-producing Klebsiella oxytoca in Brazil.
abstract: The present work reports the detection of the first case of nosocomial Klebsiella oxytoca producing class A carbapenemase KPC-2 in Brazil. The isolate KPN106 carried a 65-kb IncW-type plasmid that harbors the blaKPC gene and Tn4401b. Moreover, we detected the presence of a class 1 integron containing a new allele, arr-8, followed by a 5'-truncated dhfrIIIc gene. In view of the recent results, we emphasize the high variability of the bacterial and genetic hosts of this resistance determinant.
authors.affiliation: Laboratório de Resistência Microbiana, Instituto de Ciências Biológicas, Universidade de Pernambuco, Recife, Brazil. annacalmeida@hotmail.com
authors.forename: Anna C S
authors.initials: AC
authors.lastname: Almeida
authors.forename: Felipe L S
authors.initials: FL
authors.lastname: Cavalcanti
authors.forename: Willames M B
authors.initials: WM
authors.lastname: Martins
authors.forename: Marinalda A
authors.initials: MA
authors.lastname: Vilela
authors.forename: Ana C
authors.initials: AC
authors.lastname: Gales
authors.forename: Marcos A
authors.initials: MA
authors.lastname: Morais Junior
authors.forename: Márcia M C
authors.initials: MM
authors.lastname: Morais
mesh_terms: D000368:Aged; D000483:Alleles; D001938:Brazil; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D017809:Fatal Outcome; D005260:Female; D005798:Genes, Bacterial; D014644:Genetic Variation; D006801:Humans; D032023:Integrons; D007710:Klebsiella Infections / Q000175:diagnosis / Q000188:drug therapy; D041121:Klebsiella oxytoca / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics / Q000378:metabolism; D011112:Polymyxin B / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D004269:DNA, Bacterial; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases; D011112:Polymyxin B; D012293:Rifampin