title: Distinct functions for RIP140 in development, inflammation, and metabolism.
abstract: Nuclear receptors (NRs) regulate tissue development and function by controlling transcription from distinct sets of genes in response to fluctuating levels of hormones or cues that modulate receptor activity. Such target gene activation or repression depends on the recruitment of coactivators or corepressors that lead to chromatin remodelling in the vicinity of target genes. Similarly to receptors, coactivators and corepressors often serve pleiotropic functions, and Nrip1 (RIP140) is no exception, playing roles in animal development and physiology. At first sight, however, RIP140 is unusual in its ability to function either as a coactivator or as a corepressor, and also serve a cytoplasmic role. The functions of RIP140 in different tissues will be summarised together with its potential contribution to disease.
authors.affiliation: Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Du Cane Road, London W12 0NN, UK.
authors.forename: Jaya
authors.initials: J
authors.lastname: Nautiyal
authors.forename: Mark
authors.initials: M
authors.lastname: Christian
authors.forename: Malcolm G
authors.initials: MG
authors.lastname: Parker
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D042002:Chromatin Assembly and Disassembly / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D000078723:Nuclear Receptor Interacting Protein 1; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C000627127:NRIP1 protein, human; D009687:Nuclear Proteins; D000078723:Nuclear Receptor Interacting Protein 1; D018160:Receptors, Cytoplasmic and Nuclear
keywords: RIP140; coregulator; development; inflammation; metabolism; nuclear receptors