title: Stringent complete remission of primary plasma cell leukemia with reduced-dose bortezomib, lenalidomide and dexamethasone: a case report and review of the literature.
abstract: Plasma cell leukemia (PCL) is an aggressive variant of multiple myeloma characterized by a high level of plasma cells circulating in the peripheral blood. The prognosis of PCL patients treated with conventional chemotherapy remains poor. Some reports have suggested that both bortezomib and lenalidomide are effective in treating PCL. We herein report a case of primary PCL in which the patient achieved stringent complete remission after receiving combination chemotherapy with reduced-dose bortezomib, lenalidomide and dexamethasone (VRd). This regimen was very effective, and no severe adverse events were observed. A reduced-dose VRd regimen can be considered in PCL patients.
authors.affiliation: Department of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital, Japan. ueda0904@hp.pref.hyogo.jp
authors.forename: Shuji
authors.initials: S
authors.lastname: Ueda
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kubo
authors.forename: Noriko
authors.initials: N
authors.lastname: Matsuura
authors.forename: Hitomi
authors.initials: H
authors.lastname: Matsunaga
authors.forename: Seiko
authors.initials: S
authors.lastname: Kataoka
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Maeda
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Inui
authors.forename: Sumio
authors.initials: S
authors.lastname: Kawata
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Kanakura
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001897:Boronic Acids / Q000008:administration & dosage; D000069286:Bortezomib; D003907:Dexamethasone / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D006801:Humans; D000077269:Lenalidomide; D007952:Leukemia, Plasma Cell / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011719:Pyrazines / Q000008:administration & dosage; D012074:Remission Induction / Q000379:methods; D013792:Thalidomide / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D001897:Boronic Acids; D011719:Pyrazines; D013792:Thalidomide; D000069286:Bortezomib; D003907:Dexamethasone; D000077269:Lenalidomide