title: Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement.
abstract: Bacillus thuringiensis insecticidal toxin (Bt) rice will be commercialized as a main food source. Traditional safety assessments on genetically modified products pay little attention on gastrointestinal (GI) health. More data about GI health of Bt rice must be provided to dispel public' doubts about the potential effects on human health. We constructed an improved safety assessment animal model using a basic subchronic toxicity experiment, measuring a range of parameters including microflora composition, intestinal permeability, epithelial structure, fecal enzymes, bacterial activity, and intestinal immunity. Significant differences were found between rice-fed groups and AIN93G-fed control groups in several parameters, whereas no differences were observed between genetically modified and non-genetically modified groups. No adverse effects were found on GI health resulting from genetically modified T2A-1 rice. In conclusion, this study may offer a systematic safety assessment model for GM material with respect to the effects on GI health.
authors.affiliation: Laboratory of Food Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Yuan
authors.forename: Wentao
authors.initials: W
authors.lastname: Xu
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: He
authors.forename: Haiyan
authors.initials: H
authors.lastname: Liu
authors.forename: Sishuo
authors.initials: S
authors.lastname: Cao
authors.forename: Xiaozhe
authors.initials: X
authors.lastname: Qi
authors.forename: Kunlun
authors.initials: K
authors.lastname: Huang
authors.forename: Yunbo
authors.initials: Y
authors.lastname: Luo
mesh_terms: D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000382:microbiology; D022761:Gene Transfer, Horizontal; D018928:Immunity, Mucosal; D012275:Oryza / Q000633:toxicity; D010539:Permeability; D030821:Plants, Genetically Modified / Q000633:toxicity; D051381:Rats