title: A randomized, double-blind, placebo-controlled trial of the effect of dried purple carrot on body mass, lipids, blood pressure, body composition, and inflammatory markers in overweight and obese adults: the QUENCH trial.
abstract: Obesity is a significant health issue worldwide and is associated with chronic, low-grade inflammation predisposing the individual to cardiovascular disease and impaired blood glucose homeostasis. Anthocyanins and phenolic acids from purple carrots are effective at reversing inflammation and metabolic alterations in animal models, potentially through inhibition of inflammatory pathways. The effects of dried purple carrot on body mass, body composition, blood pressure, lipids, inflammatory markers, liver function tests, and appetite were investigated in 16 males (aged 53.1 ± 7.6 years and with a mean BMI of 32.8 ± 4.6 kg/m(2)) with normal lipid and inflammatory markers. There was no evidence that 118.5 mg/day of anthocyanins and 259.2 mg/day of phenolic acids for 4 weeks resulted in statistically significant changes in body mass, body composition, appetite, dietary intake, low density lipoprotein, total cholesterol, blood pressure, or C-reactive protein in these obese participants at the dose and length of intervention used in this trial. High density lipoprotein cholesterol was lower in the intervention group (p < 0.05). Aspartate amino transferase and alanine amino transferase did not change, indicating that the intervention was safe. More studies are required to establish the bioavailability and pharmacokinetic effects of purple carrot anthocyanins and phenolic acids prior to further trials of efficacy with respect to treating inflammation and metabolic alterations.
authors.affiliation: Centre for Dietetics Research (C-DIET-R), School of Human Movement Studies, and the Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, Queensland, Australia. o.wright@uq.edu.au
authors.forename: Olivia R L
authors.initials: OR
authors.lastname: Wright
authors.forename: Gabriele A
authors.initials: GA
authors.lastname: Netzel
authors.forename: Amy R
authors.initials: AR
authors.lastname: Sakzewski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000872:Anthocyanins / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D001823:Body Composition / Q000187:drug effects; D015992:Body Mass Index; D016207:Cytokines / Q000097:blood / Q000276:immunology; D018552:Daucus carota / Q000737:chemistry*; D019587:Dietary Supplements; D004311:Double-Blind Method; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects; D009765:Obesity / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D050177:Overweight / Q000276:immunology* / Q000378:metabolism / Q000517:prevention & control*; D010865:Pilot Projects; D055815:Young Adult
chemical_list: D000872:Anthocyanins; D015415:Biomarkers; D016207:Cytokines; D008055:Lipids