title: Total cholesterol and lipoprotein composition are associated with dry eye disease in Korean women.
abstract: BACKGROUND
  This study aimed to determine the relationship between dyslipidemia and dry eye disease (DED) in a Korean population.
  
  
  METHODS
  This population-based study enrolled 5,627 adults (aged >19 years) who were participating in the first year of the fifth annual Korea National Health and Nutrition Examination Survey from 2010 to 2011. Clinically diagnosed DED and its symptoms were surveyed, and biochemical blood analysis data were collected. Dyslipidemia was defined as any of the following: hypercholesterolemia (total cholesterol > 200 mg/dL), hypertriglyceridemia (triglyceride > 150 mg/dL), low levels of high-density lipoprotein (<40 mg/dL), or high levels of low-density lipoprotein (>100 mg/dL).
  
  
  RESULTS
  After adjusting for demographics (age and body mass index), lifestyle (smoking, drinking, exercise, and residential district), and medical factors (diabetes, hypertension, previous ophthalmic surgery, menopause, and rheumatologic disease), elevated serum cholesterol level was found to be associated with increased likelihood of DED (odds ratio, 1.77; 95% confidence interval, 1.127-2.78) in women.
  
  
  CONCLUSIONS
  DED in a Korean population was found to be associated with high serum cholesterol levelsThe results of this study highlight the significance of eye examinations and independent lipid profile monitoring in patients with dyslipidemia because of its possible correlation with DED progression.
authors.affiliation: Department of Pediatrics, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
authors.forename: Yoon Hong
authors.initials: YH
authors.lastname: Chun
authors.forename: Hye Rang
authors.initials: HR
authors.lastname: Kim
authors.forename: Kyungdo
authors.initials: K
authors.lastname: Han
authors.forename: Yong-Gyu
authors.initials: YG
authors.lastname: Park
authors.forename: Ho Jin
authors.initials: HJ
authors.lastname: Song
authors.forename: Kyung-Sun
authors.initials: KS
authors.lastname: Na
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood* / Q000235:genetics; D015352:Dry Eye Syndromes / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D007723:Korea; D008074:Lipoproteins / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D009749:Nutrition Surveys
chemical_list: D008074:Lipoproteins; D002784:Cholesterol