title: Efficacy of HPA Lanolin® in treatment of lip alterations related to chemotherapy.
abstract: The side effects of chemotherapy on the lips may cause esthetic and functional impact and increase the risk of infection. HPA Lanolin® is an option for supportive therapy because it has anti-inflammatory, antimicrobial and moisturizing properties.
  
  
  OBJECTIVE
  To evaluate the efficacy of this product in the prevention of lip alterations in a population of patients undergoing chemotherapy.
  
  
  METHODS
  Patients undergoing chemotherapy (n = 57) were examined and distributed into two groups: study (used HPA Lanolin®) and control (without supportive therapy on the lips). We evaluated the patients two weeks after chemotherapy, registering oral alterations, symptoms of pain, discomfort, limitation of mouth opening and dehydration, classified according to a visual analogue scale.
  
  
  RESULTS
  Patients who used HPA Lanolin® had lower dehydration and experienced improvement of lip dryness (p<0.001). The main symptoms were dehydration, discomfort, limitation of mouth opening, pain. The main clinical signs were dry lips, mucositis, cheilitis, hematoma, swelling and cracking. We found no difference concerning the variables of pain, discomfort, and limitation of mouth opening between the study and control group.
  
  
  CONCLUSIONS
  We suggest that HPA Lanolin® is effective in reducing the symptoms of dehydration and the signs of lip dryness resulting from toxicity of chemotherapy, proving to be an interesting alternative supportive therapy for cancer patients.
authors.affiliation: Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil. paulosss@fob.usp.br
authors.forename: Paulo Sérgio da Silva
authors.initials: PS
authors.lastname: Santos
authors.forename: José Endrigo
authors.initials: JE
authors.lastname: Tinôco-Araújo
authors.forename: Lucas Monteiro de Vasconcelos Alves de
authors.initials: LM
authors.lastname: Souza
authors.forename: Rafael
authors.initials: R
authors.lastname: Ferreira
authors.forename: Maura Rosane Valério
authors.initials: MR
authors.lastname: Ikoma
authors.forename: Ana Paula Ribeiro
authors.initials: AP
authors.lastname: Razera
authors.forename: Márcia Mirolde Magno de Carvalho
authors.initials: MM
authors.lastname: Santos
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003358:Cosmetics / Q000627:therapeutic use*; D003681:Dehydration / Q000517:prevention & control; D005260:Female; D006801:Humans; D007809:Lanolin / Q000627:therapeutic use*; D008046:Lip / Q000187:drug effects*; D008297:Male; D052016:Mucositis / Q000517:prevention & control; D009369:Neoplasms / Q000188:drug therapy; D010146:Pain / Q000517:prevention & control; D010147:Pain Measurement; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D003358:Cosmetics; D007809:Lanolin