title: Radiation pressure on a biconcave human Red Blood Cell and the resulting deformation in a pair of parallel optical traps.
abstract: We calculated the three-dimensional optical stress distribution and the resulting deformation on a biconcave human red blood cell (RBC) in a pair of parallel optical trap. We assumed a Gaussian intensity distribution with a spherical wavefront for each trapping beam and calculated the optical stress from the momentum transfer associated with the reflection and refraction of the incident photons at each interface. The RBC was modelled as a biconcave thin elastic membrane with uniform elasticity and a uniform thickness of 0.25 μm. The resulting cell deformation was determined from the optical stress distribution by finite element software, Comsol Structure Mechanics Module, with Young's modulus (E) as a fitting parameter in order to fit the theoretical results for cell elongation to our experimental data.
authors.affiliation: Institute of Atomic and Molecular Science, Taipei, Taiwan; Molecular Science and Technology Program, Taiwan International Graduate Program TIGP, Academia Sinica, Taiwan.
authors.forename: Guan-Bo
authors.initials: GB
authors.lastname: Liao
authors.forename: Yin-Quan
authors.initials: YQ
authors.lastname: Chen
authors.forename: Paul B
authors.initials: PB
authors.lastname: Bareil
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Sheng
authors.forename: Arthur
authors.initials: A
authors.lastname: Chiou
authors.forename: Ming-Shien
authors.initials: MS
authors.lastname: Chang
mesh_terms: D048430:Cell Shape / Q000502:physiology / Q000528:radiation effects*; D003198:Computer Simulation; D055119:Elastic Modulus; D004912:Erythrocytes / Q000166:cytology* / Q000502:physiology / Q000528:radiation effects*; D006801:Humans; D008954:Models, Biological; D016011:Normal Distribution; D052898:Optical Tweezers; D017785:Photons; D011312:Pressure
keywords: Red Blood Cell (RBC); cell mechanics; optical tweezers; radiation pressure