title: Synthesis of tetrasubstituted pyrroles from terminal alkynes and imines.
abstract: Tetrasubstituted pyrroles can be obtained via the reaction of terminal alkynes and imines using (n)BuLi as the base in one step with high chemoselectivity (method 1). Alternatively, the intermediate propargylamines can also react with imines to afford tetrasubstituted pyrroles when using LiHMDS as the base (method 2), which provides a complementary method to construct the pyrroles with different substituents.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road, Dalian 116023, China.
authors.forename: Yancheng
authors.initials: Y
authors.lastname: Hu
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Wang
authors.forename: Dongping
authors.initials: D
authors.lastname: Wang
authors.forename: Fan
authors.initials: F
authors.lastname: Wu
authors.forename: Boshun
authors.initials: B
authors.lastname: Wan
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D010293:Pargyline / Q000031:analogs & derivatives / Q000737:chemistry; D011437:Propylamines / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D007097:Imines; D011437:Propylamines; D011758:Pyrroles; C009054:propargylamine; D010293:Pargyline