title: Different plasticity patterns of language function in children with perinatal and childhood stroke.
abstract: Plasticity of language function after brain damage can depend on maturation of the brain. Children with left-hemisphere perinatal (n = 7) or childhood stroke (n = 5) and 12 controls were investigated using functional magnetic resonance imaging. The verb generation and the sentence comprehension tasks were employed to activate the expressive and receptive language areas, respectively. Weighted laterality indices were calculated and correlated with results assessed by neuropsychological test battery. Compared to controls, children with childhood stroke showed significantly lower mean scores for the expressive (P < .05) and receptive (P = .05) language tests. On functional magnetic resonance imaging they showed left-side cortical activation, as did controls. Perinatal stroke patients showed atypical right-side or bilateral language lateralization during both tasks. Negative correlation for stroke patients was found between scores for expressive language tests and laterality index during the verb generation task. (Re)organization of language function differs in children with perinatal and childhood stroke and correlates with neurocognitive performance.
authors.affiliation: Radiology Clinic of Tartu University Hospital, Department of Radiology, University of Tartu, Tartu, Estonia pilvi.ilves@kliinikum.ee.
authors.forename: Pilvi
authors.initials: P
authors.lastname: Ilves
authors.affiliation: Radiology Clinic of Tartu University Hospital and Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia.
authors.forename: Tiiu
authors.initials: T
authors.lastname: Tomberg
authors.affiliation: Diagnostic Service, Pärnu Hospital, Pärnu, Estonia.
authors.forename: Joosep
authors.initials: J
authors.lastname: Kepler
authors.affiliation: Department of Neurology and Neurorehabilitation, University of Tartu and Children's Clinic of Tartu University Hospital, Tartu, Estonia.
authors.forename: Rael
authors.initials: R
authors.lastname: Laugesaar
authors.affiliation: Institute of Physics, University of Tartu, Tartu, Estonia.
authors.forename: Mari-Liis
authors.initials: ML
authors.lastname: Kaldoja
authors.affiliation: Institute of Physics, University of Tartu, Tartu, Estonia.
authors.forename: Kalle
authors.initials: K
authors.lastname: Kepler
authors.affiliation: Department of Neurology and Neurorehabilitation, University of Tartu and Children's Clinic of Tartu University Hospital, Tartu, Estonia.
authors.forename: Anneli
authors.initials: A
authors.lastname: Kolk
mesh_terms: D000293:Adolescent; D001921:Brain / Q000098:blood supply / Q000473:pathology; D016022:Case-Control Studies; D002648:Child; D016001:Confidence Intervals; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007805:Language Development Disorders / Q000145:classification / Q000175:diagnosis* / Q000209:etiology*; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D012044:Regression Analysis; D020521:Stroke / Q000150:complications* / Q000175:diagnosis
chemical_list: D010100:Oxygen
keywords: brain plasticity; childhood stroke; functional magnetic resonance imaging; language; perinatal stroke