title: The CCM3-GCKIII partnership.
abstract: Specific mutations in the CCM3 gene predispose to the development of cerebral cavernous malformations, a special type of vascular lesions. This calls for an elucidation of the precise nature of the CCM3 protein and a deep understanding of its molecular regulation. In this review, we outline our current knowledge of the different CCM3 protein complexes. We focus on the GCKIII family of kinases as partners of CCM3 and discuss the functional consequences of this partnership, putting forward a putative model for the activation of these kinases.
authors.affiliation: Department of Physiology and Centro Singular de Medicina Molecular y Enfermedades Crónicas (CIMUS), University of Santiago de Compostela, and the Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain. juan.zalvide@usc.es.
authors.forename: Juan
authors.initials: J
authors.lastname: Zalvide
authors.forename: Miguel
authors.initials: M
authors.lastname: Fidalgo
authors.forename: María
authors.initials: M
authors.lastname: Fraile
authors.forename: Ana
authors.initials: A
authors.lastname: Guerrero
authors.forename: Cristina
authors.initials: C
authors.lastname: Iglesias
authors.forename: Ebel
authors.initials: E
authors.lastname: Floridia
authors.forename: Celia M
authors.initials: CM
authors.lastname: Pombo
mesh_terms: D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000235:genetics* / Q000378:metabolism*; D019281:Dimerization; D004789:Enzyme Activation; D015971:Gene Expression Regulation, Enzymologic; D020022:Genetic Predisposition to Disease; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism*; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D015398:Signal Transduction; D000099317:Hippo Kinases
chemical_list: D051017:Apoptosis Regulatory Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; C495390:PDCD10 protein, human; C109163:STK24 protein, human; D000099317:Hippo Kinases; C430908:STK26 protein, human; C530660:STK25 protein, human