title: [The role of IL-6 in the development of morphological changes in renal tissue in elderly patients with type 2 diabetes complicated by diabetic nephropathy].
abstract: Studies in recent years suggest a role for inflammation, proinflammatory cytokines in particular, the development of microvascular complications of diabetes, including nephropathy. We investigated the expression of IL-6 in the biopsy tissue kidneys (in glomeruli and interstitium) in 24 elderly patients with type 2 diabetes complicated by diabetic nephropathy. The significant influence of intrarenal expression of IL-6 on the development of morphological (glomerular and tubulointerstitial) changes in renal tissue in patients with diabetic nephropathy is shown.
authors.forename: I A
authors.initials: IA
authors.lastname: Rakitianskaia
authors.forename: S I
authors.initials: SI
authors.lastname: Riabov
authors.forename: A G
authors.initials: AG
authors.lastname: Dubrova
authors.forename: S V
authors.initials: SV
authors.lastname: Azanchevskaia
authors.forename: T S
authors.initials: TS
authors.lastname: Riabova
authors.forename: A S
authors.initials: AS
authors.lastname: Gurkov
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D003928:Diabetic Nephropathies / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D004730:Endothelium, Vascular / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis / Q000502:physiology*; D007668:Kidney / Q000098:blood supply / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D007677:Kidney Function Tests; D008297:Male; D008856:Microscopy, Fluorescence
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6