title: Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry.
abstract: OBJECTIVE
  To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC.
  
  
  METHODS
  Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined.
  
  
  RESULTS
  A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records.
  
  
  CONCLUSIONS
  These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC.
authors.affiliation: Cancer Prevention, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. sadams@fhcrc.org
authors.forename: Scott V
authors.initials: SV
authors.lastname: Adams
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Ahnen
authors.forename: John A
authors.initials: JA
authors.lastname: Baron
authors.forename: Peter T
authors.initials: PT
authors.lastname: Campbell
authors.forename: Steven
authors.initials: S
authors.lastname: Gallinger
authors.forename: William M
authors.initials: WM
authors.lastname: Grady
authors.forename: Loic
authors.initials: L
authors.lastname: LeMarchand
authors.forename: Noralane M
authors.initials: NM
authors.lastname: Lindor
authors.forename: John D
authors.initials: JD
authors.lastname: Potter
authors.forename: Polly A
authors.initials: PA
authors.lastname: Newcomb
mesh_terms: D000368:Aged; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality; D053208:Kaplan-Meier Estimate; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010375:Pedigree; D011379:Prognosis; D016016:Proportional Hazards Models; D012042:Registries; D012307:Risk Factors; D017741:Survivors / Q000706:statistics & numerical data*; D013997:Time Factors; D014481:United States / Q000453:epidemiology
keywords: Cancer survival; Colorectal cancer; Inflammation; Inflammatory bowel disease; Outcomes research