title: Exacerbation and remission of pulmonary micronodules with lymphangioleiomyomatosis around the time of childbirth.
abstract: We present a case of multifocal micronodular pneumocyte hyperplasia (MMPH), lymphangiomyomatosis (LAM) and angiomyolipoma (AML) in a 33-year-old woman with tuberous sclerosis complex referred to us during her first pregnancy. Computed tomography of the chest showed diffuse micronodules and cysts in both lungs. Compared to those before pregnancy, the number of micronodules increased evidently. We hypothesized the micronodules in both lungs were either LAM, MMPH, or a combination of the two. Bilateral renal AML also intensified. About one month after childbirth, LAM and renal AML decreased without treatment. Therefore, we observed that LAM and AML were affected by the pregnancy. To the best of our knowledge, this is the first case report regarding the reversible alteration of LAM without treatment.
authors.affiliation: Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan, qq8y7cvd@tiara.ocn.ne.jp.
authors.forename: Ryo
authors.initials: R
authors.lastname: Ogawa
authors.forename: Masao
authors.initials: M
authors.lastname: Miyagawa
authors.forename: Kana
authors.initials: K
authors.lastname: Ide
authors.forename: Akihisa
authors.initials: A
authors.lastname: Akamune
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ohtsuki
authors.forename: Teruhito
authors.initials: T
authors.lastname: Mochizuki
mesh_terms: D000328:Adult; D018207:Angiomyolipoma / Q000150:complications / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000150:complications / Q000000981:diagnostic imaging; D007668:Kidney / Q000000981:diagnostic imaging; D007680:Kidney Neoplasms / Q000150:complications / Q000000981:diagnostic imaging*; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging*; D018192:Lymphangioleiomyomatosis / Q000150:complications / Q000000981:diagnostic imaging*; D009365:Neoplasm Regression, Spontaneous; D036801:Parturition; D049590:Postpartum Period; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods; D014402:Tuberous Sclerosis / Q000150:complications