title: Therapeutic translation of iPSCs for treating neurological disease.
abstract: Somatic cellular reprogramming is a fast-paced and evolving field that is changing the way scientists approach neurological diseases. For the first time in the history of neuroscience, it is feasible to study the behavior of live neurons from patients with neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, and neuropsychiatric diseases, such as autism and schizophrenia. In this Perspective, we will discuss reprogramming technology in the context of its potential use for modeling and treating neurological and psychiatric diseases and will highlight areas of caution and opportunities for improvement.
authors.affiliation: The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Diana X
authors.initials: DX
authors.lastname: Yu
authors.forename: Maria C
authors.initials: MC
authors.lastname: Marchetto
authors.forename: Fred H
authors.initials: FH
authors.lastname: Gage
mesh_terms: D006801:Humans; D009422:Nervous System Diseases / Q000473:pathology / Q000628:therapy*; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000637:transplantation*