title: Physical activity and other lifestyle factors in relation to the prevalence of colorectal adenoma: a colonoscopy-based study in asymptomatic Koreans.
abstract: OBJECTIVE
  To evaluate physical activity and other lifestyle risk factors in relation to the prevalence of colorectal adenomas in asymptomatic Koreans.
  
  
  METHODS
  A total of 1,526 asymptomatic subjects who underwent a colonoscopy were enrolled. Lifestyle factors such as physical activity and smoking data were obtained using a questionnaire. The subjects were grouped into three exposure levels by tertiles of metabolic equivalent hours per week. We evaluated the risk factors in subjects with adenomas by risk stratification (low-risk adenoma group vs. high-risk adenoma group) and by anatomic location (proximal colon, distal colon, rectum, and multiple locations). The high-risk adenoma group was defined as subjects with advanced adenomas or multiple (≥ 3) adenomas.
  
  
  RESULTS
  A total of 456 participants had colorectal adenomas, and 861 had no polyps. In multivariate analyses, higher levels of physical activity were associated with a significantly decreased risk of colorectal adenomas (OR = 0.56, 95% CI 0.40-0.79). This inverse association was stronger for the risk of high-risk adenomas (OR = 0.39, 95% CI 0.21-0.73) than for low-risk adenomas (OR = 0.62, 95% CI 0.43-0.89). The negative relation of physical activity was significant for distal colon adenomas (OR = 0.54, 95% CI 0.30-0.95) and the adenomas with multiple locations (OR = 0.39, 95% CI 0.21-0.72).
  
  
  CONCLUSIONS
  Increased physical activity is associated with a reduced prevalence of colorectal adenomas. The inverse association between physical activity and adenoma was stronger for the risk of advanced or multiple adenomas.
authors.affiliation: Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, 39th Floor, Gangnam Finance Center, 737 Yeoksam-dong, Gangnam-gu, Seoul, 135-984, Korea.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Song
authors.forename: Young Sun
authors.initials: YS
authors.lastname: Kim
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Yang
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Chung
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Park
authors.forename: Seon Hee
authors.initials: SH
authors.lastname: Lim
authors.forename: Jeong Yoon
authors.initials: JY
authors.lastname: Yim
authors.forename: Joo Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Hyun Chae
authors.initials: HC
authors.lastname: Jung
mesh_terms: D000236:Adenoma / Q000453:epidemiology* / Q000473:pathology; D000328:Adult; D000368:Aged; D003113:Colonoscopy / Q000379:methods; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000473:pathology; D003430:Cross-Sectional Studies; D055088:Early Detection of Cancer / Q000379:methods; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D009043:Motor Activity; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors