title: Perna canaliculus lipid complex PCSO-524™ demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control.
abstract: Osteoarthritis (OA) typically generates pain, reduced mobility and reduced quality of life. Most conventional treatments for osteoarthritis, such as non-steroidal anti-inflammatory drugs (NSAIDs) and simple analgesics, have side effects. PCSO-524™, a non polar lipid extract from the New Zealand Green Lipped Mussel, is rich in omega-3 fatty acids and has been shown to reduce inflammation in both animal studies and patient trials. This OA trial examined pain relief changes in relation to quality of life and safety of use for OA patients who took PCSO-524™ compared with patients who took fish oil (containing an industry standard EPA-18% and DHA-12% blend). PCSO-524™ patients showed a statistically significant improvement compared with patients who took fish oil. There was an 89% decrease in their pain symptoms and 91% reported an improved quality of life. Patients treated with fish oil showed significantly less improvement and a greater level of physical discomfort during the study. These results suggest that PCSO-524™ might offer a potential alternative complementary therapy with no side effects for OA patients.
authors.affiliation: Clinic of Rheumatology and Internal Medicine, Academic Clinical Hospital, Wroclaw 50-556, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Zawadzki
authors.forename: Claudia
authors.initials: C
authors.lastname: Janosch
authors.forename: Jacek
authors.initials: J
authors.lastname: Szechinski
mesh_terms: D000368:Aged; D000818:Animals; D000529:Complementary Therapies / Q000379:methods; D004281:Docosahexaenoic Acids / Q000009:adverse effects / Q000627:therapeutic use; D004311:Double-Blind Method; D015118:Eicosapentaenoic Acid / Q000009:adverse effects / Q000627:therapeutic use; D015525:Fatty Acids, Omega-3 / Q000009:adverse effects / Q000302:isolation & purification / Q000627:therapeutic use; D005260:Female; D005395:Fish Oils / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008055:Lipids / Q000009:adverse effects / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000150:complications*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D049883:Perna / Q000737:chemistry*; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D008055:Lipids; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid