title: The necessity of nuclear reactors for targeted radionuclide therapies.
abstract: Nuclear medicine has been contributing towards personalized therapies. Nuclear reactors are required for the working horses of both diagnosis and treatment, i.e., Tc-99m and I-131. In fact, reactors will remain necessary to fulfill the demand for a variety of radionuclides and are essential in the expanding field of targeted radionuclide therapies for cancer. However, the main reactors involved in the global supply are ageing and expected to shut down before 2025. Therefore, the fields of (nuclear) medicine, nuclear industry and politics share a global responsibility, faced with the task to secure future access to suitable nuclear reactors. At the same time, alternative production routes should be industrialized. For this, a coordinating entity should be put into place.
authors.affiliation: Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. g.c.krijger@umcutrecht.nl
authors.forename: Gerard C
authors.initials: GC
authors.lastname: Krijger
authors.forename: Bernard
authors.initials: B
authors.lastname: Ponsard
authors.forename: Mark
authors.initials: M
authors.lastname: Harfensteller
authors.forename: Hubert T
authors.initials: HT
authors.lastname: Wolterbeek
authors.forename: Johannes W F
authors.initials: JW
authors.lastname: Nijsen
mesh_terms: D014943:Global Health; D006291:Health Policy; D009683:Nuclear Medicine / Q000379:methods*; D009688:Nuclear Reactors / Q000706:statistics & numerical data*; D057285:Precision Medicine / Q000379:methods; D011868:Radioisotopes / Q000302:isolation & purification / Q000627:therapeutic use*; D011878:Radiotherapy / Q000379:methods*
chemical_list: D011868:Radioisotopes