title: Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides.
abstract: A ligand-free method for the Pd-catalyzed direct arylation of cyclic enaminones using aryl iodides was developed. This method can be applied to a wide range of cyclic enaminones and aryl iodides with excellent C5-regioselectivity. Using widely available aryl iodides, the generality of this transformation provides easy access to a variety of 3-arylpiperidine structural motifs.
authors.affiliation: Department of Chemistry, the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, United States.
authors.forename: Yi-Yun
authors.initials: YY
authors.lastname: Yu
authors.forename: Lei
authors.initials: L
authors.lastname: Bi
authors.forename: Gunda I
authors.initials: GI
authors.lastname: Georg
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010880:Piperidines / Q000138:chemical synthesis*; D011728:Pyridones / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D010880:Piperidines; D011728:Pyridones; D010165:Palladium; D007455:Iodine