title: Short communication: The relationship between mitochondrial dysfunction and insulin resistance in HIV-infected children receiving antiretroviral therapy.
abstract: Mitochondrial abnormalities may lead to metabolic complications in HIV-infected children who have been receiving long-term antiretroviral treatment. We conducted a matched, case-control study comparing 21 HIV-infected children with insulin resistance (cases) to 21 HIV-infected children without insulin resistance (controls) to assess differences in mitochondrial DNA (mtDNA) copies/cell and oxidative phosphorylation NADH dehydrogenase (C1) and cytochrome c oxidase (C4) enzyme activities in peripheral blood mononuclear cells. MtDNA copies/cell tended to be lower in cases, and fasting serum glucose levels were inversely and significantly correlated with C1 enzyme activity, more so in cases. Larger pediatric studies should evaluate mitochondrial etiologies of insulin resistance and determine the role of antiretroviral therapies or HIV infection on mitochondrial dysfunction.
authors.affiliation: Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts 02115, USA. tanvi.sharma@childrens.harvard.edu
authors.forename: Tanvi S
authors.initials: TS
authors.lastname: Sharma
authors.forename: Denise L
authors.initials: DL
authors.lastname: Jacobson
authors.forename: Lynn
authors.initials: L
authors.lastname: Anderson
authors.forename: Mariana
authors.initials: M
authors.lastname: Gerschenson
authors.forename: Russell B
authors.initials: RB
authors.lastname: Van Dyke
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: McFarland
authors.forename: Tracie L
authors.initials: TL
authors.lastname: Miller
mesh_terms: D000293:Adolescent; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D001786:Blood Glucose; D016022:Case-Control Studies; D002648:Child; D004272:DNA, Mitochondrial / Q000235:genetics / Q000378:metabolism; D042967:Electron Transport Complex I / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D010085:Oxidative Phosphorylation
chemical_list: D044966:Anti-Retroviral Agents; D001786:Blood Glucose; D004272:DNA, Mitochondrial; D003576:Electron Transport Complex IV; D042967:Electron Transport Complex I