title: Etoposide and temozolomide in combination for the treatment of progressive small-cell lung cancer central nervous system metastases: two cases.
abstract: BACKGROUND
  Progression of central nervous system (CNS) metastases from small cell lung cancer (SCLC) after radiation therapy is associated with a poor prognosis.
  
  
  METHODS
  We present two cases of patients with progressive CNS metastases from SCLC treated with oral temozolomide and etoposide. Sustained clinical responses and radiographic stability were demonstrated. The palliative chemotherapy regimen was well tolerated.
  
  
  CONCLUSIONS
  A regimen of oral temozolomide and etoposide for progressive CNS metastases from SCLC is well tolerated and may be associated with sustained stability of disease.
authors.affiliation: Department of Neurology, University of Chicago, Chicago, IL, USA. rlukas@neurology.bsd.uchicago.edu
authors.forename: Rimas V
authors.initials: RV
authors.lastname: Lukas
authors.forename: Janani
authors.initials: J
authors.lastname: Vigneswaran
authors.forename: Ravi
authors.initials: R
authors.lastname: Salgia
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000209:etiology / Q000556:secondary*; D003606:Dacarbazine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D018450:Disease Progression; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D017809:Fatal Outcome; D005260:Female; D017051:Hospice Care; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000473:pathology*; D008875:Middle Aged; D010166:Palliative Care; D018714:Radiotherapy, Adjuvant; D012907:Smoking / Q000009:adverse effects; D013120:Spinal Cord Neoplasms / Q000188:drug therapy* / Q000556:secondary; D000077204:Temozolomide
chemical_list: D005047:Etoposide; D003606:Dacarbazine; D000077204:Temozolomide