title: Inhibition of ErbB receptors, Hedgehog and NF-kappaB signaling by polyphenols in cancer.
abstract: Carcinogenesis is a multi-step process triggered by cumulative genetic alterations, which drive the progressive transformation of a normal cell into a cancer cell. Among the signal transduction pathways whose cross-talk plays an important role in neoplastic transformation are those mediated by ErbB receptors, NF-kappaB and the Hedgehog (HH)/glioma-associated oncogene (GLI) cascade. Polyphenols can be employed to inhibit the growth of cancer cells due to their ability to modulate the activity of multiple targets involved in carcinogenesis through simultaneous direct interaction or modulation of gene expression. This review will describe the cross-talk between ErbB receptors, NF-kappaB and the Hedgehog (HH)/glioma-associated oncogene (GLI) signaling pathways and the potential role of polyphenols in inhibiting this dialogue and the growth of cancer cells.
authors.affiliation: Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Benvenuto
authors.forename: Massimo
authors.initials: M
authors.lastname: Fantini
authors.forename: Laura
authors.initials: L
authors.lastname: Masuelli
authors.forename: Enrico
authors.initials: E
authors.lastname: De Smaele
authors.forename: Francesca
authors.initials: F
authors.lastname: Zazzeroni
authors.forename: Ilaria
authors.initials: I
authors.lastname: Tresoldi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Calabrese
authors.forename: Fabio
authors.initials: F
authors.lastname: Galvano
authors.forename: Andrea
authors.initials: A
authors.lastname: Modesti
authors.forename: Roberto
authors.initials: R
authors.lastname: Bei
mesh_terms: D045744:Cell Line, Tumor; D066246:ErbB Receptors / Q000378:metabolism*; D053823:Hedgehog Proteins / Q000378:metabolism*; D006801:Humans; D008264:Macrophages / Q000187:drug effects; D016328:NF-kappa B / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D059808:Polyphenols / Q000494:pharmacology*; D020239:Receptor Cross-Talk; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D053823:Hedgehog Proteins; D016328:NF-kappa B; D059808:Polyphenols; C512478:EGFR protein, human; D066246:ErbB Receptors