title: Effect of insulin therapy on IGF-1 level in children with new-onset type 1 diabetes mellitus: a comparison between DKA and non-DKA.
abstract: OBJECTIVE
  The issue of insulin-like growth factor 1 (IGF-1) and diabetes in adults and type 2 diabetes has been well investigated. A few studies have investigated the serum IGF-1 level at the onset of type 1 diabetes mellitus (T1DM) in children. In the present study, we investigated the IGF-1 level of T1DM children before and after insulin therapy.
  
  
  METHODS
  Between August 2011 and October 2012, 62 children with newly diagnosed T1DM were recruited. Serum IGF-1 levels were compared before and 1 month after insulin therapy between diabetic ketoacidosis (DKA) and non-DKA patients.
  
  
  RESULTS
  Thirty-one patients without DKA (18 girls and 13 boys, mean age 8.8 ± 3.01 years) and 31 patients with DKA (18 girls and 13 boys, mean age 8.3 ± 3.7 years) were studied. The mean IGF-1 in the DKA group was lower than that in the non-DKA group; however, this difference was not statistically significant (p=0.10). Serum IGF-1 levels increased significantly 1 month after insulin therapy in both the DKA (p<0.001) and non-DKA (p<0.001) groups.
  
  
  CONCLUSIONS
  Serum IGF-1 level is reduced in new-onset T1DM children. A significant increase in serum IGF-1 level can occur with insulin therapy in both DKA and non-DKA children.
authors.forename: Siamak
authors.initials: S
authors.lastname: Shiva
authors.forename: Haleh
authors.initials: H
authors.lastname: Behbod
authors.forename: Robabeh
authors.initials: R
authors.lastname: Ghergherechi
mesh_terms: D000293:Adolescent; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D016883:Diabetic Ketoacidosis / Q000517:prevention & control*; D015536:Down-Regulation / Q000187:drug effects; D004351:Drug Resistance; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007223:Infant; D007328:Insulin / Q000627:therapeutic use*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D012720:Severity of Illness Index; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D007004:Hypoglycemic Agents; C583557:IGF1 protein, human; D007328:Insulin; D007334:Insulin-Like Growth Factor I