title: [Investigation on pharmacokinetics of aminophylline in very low birth weight infants].
abstract: OBJECTIVE
  To investigate the pharmacokinetics of aminophylline in very low birth weight infant.
  
  
  METHODS
  This study investigated 104 very low birth weight infants using aminophylline 5 mg/kg treating apnea who were hospitalized in our department during 2011-2012. The blood concentration of aminophylline was measured in 30 min before, 8 h and 5 d after first time loading dose, and was counterchecked every week before aminophylline withdrawal. The pharmacokinetic parameters of aminophylline were calculated and population pharmacokinetic model was established by MW/Pharm3.6 statistical analysis.
  
  
  RESULTS
  The average birth weight of these 104 very low birth weight infants was (1.15 +/- 0.23) kg, average gestational age was (31.19 +/- 2.50) weeks. The results of aminophylline pharmacokinetics showed: the plasma clearance was (17.88 +/- 5.61) mL/(kg x h), the apparent volume of distribution was (0.93 +/- 0.18) L/kg, the half life time was (28.6 +/- 7.59) h. The aminophylline plasma clearance was related to creatinine clearance, gestational age and days of age after birth (related coefficient was 0.68, 0.62, 0.56 respectively, P < 0.05),the apparent volume of distribution was related to birth weight (related coefficient was 0.82, P < 0.05). The population pharmacokinetics model established can predict the concentration-time curve of the patients.
  
  
  CONCLUSIONS
  The pharmacokinetics of aminophylline in very low birth weight infant was quite different from adult, which suggest blood concentration monitoring and dose adjustment for the clinical use of aminophylline in low birth weight infants.
authors.affiliation: Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Chen
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiong
authors.forename: Jun
authors.initials: J
authors.lastname: Tang
authors.forename: Jin-Lin
authors.initials: JL
authors.lastname: Wu
authors.forename: De-Zhi
authors.initials: DZ
authors.lastname: Mu
mesh_terms: D000628:Aminophylline / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001049:Apnea / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000378:metabolism*; D008297:Male
chemical_list: D000628:Aminophylline