title: Palladium-catalyzed migratory insertion of isocyanides: an emerging platform in cross-coupling chemistry.
abstract: Isocyanides have been important building blocks in organic synthesis since the discovery of the Ugi reaction and related isocyanide-based multicomponent reactions. In the past decade isocyanides have found a new application as versatile C1 building blocks in palladium catalysis. Palladium-catalyzed reactions involving isocyanide insertion offer a vast potential for the synthesis of nitrogen-containing fine chemicals. This Minireview discusses all the achievements in this emerging field.
authors.affiliation: Department of Chemistry & Pharmaceutical Sciences and Amsterdam Institute for Molecules Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.
authors.forename: Tjøstil
authors.initials: T
authors.lastname: Vlaar
authors.forename: Eelco
authors.initials: E
authors.lastname: Ruijter
authors.forename: Bert U W
authors.initials: BU
authors.lastname: Maes
authors.forename: Romano V A
authors.initials: RV
authors.lastname: Orru
keywords: heterocycles; homogeneous catalysis; isocyanides; palladium; synthetic methods