title: 18F-FDG-PET/CT in potentially advanced renal cell carcinoma: a role in treatment decisions and prognosis estimation.
abstract: OBJECTIVE
  to assess the influence of positron emission tomography/computed tomography with (18)F-fluorodeoxyglucose ((18)F-FDG-PET/CT) on the treatment decision in renal cell carcinoma and to assess the prognostic value of the (18)F-FDG accumulation assessments.
  
  
  METHODS
  Data from 60 patients were included. The cohort consisted of 43 males, 17 females, mean age 66.2 years (range=49-86 years). All patients underwent (18)F-FDG-PET/CT including two-phase CT-angiography of the kidneys. Locally advanced or generalized renal cell carcinoma was suspected in all patients. The level of the (18)F-FDG accumulation within the tumor was compared with the histological grading and the development of the disease was assessed 12 months after (18)F-FDG-PET/CT.
  
  
  RESULTS
  Overall mortality reached 46.7%, the highest (18)F-FDG accumulation showed tumor of grade 4 (mean SUV(max)=10.7, range=5-23), the highest mortality was found for tumors exceeding SUV(max) value of 10 (mortality 62.5%). New information was brought by (18)F-FDG-PET/CT in 85% of cases.
  
  
  CONCLUSIONS
  (18)F-FDG-PET/CT has the potential to estimate the patient's survival according to the (18)F-FDG accumulation measured in SUV(max). Depiction of occult metastatic disease has an emerging role in decision making regarding surgery.
authors.affiliation: Clinic of Imaging Methods, Charles University Teaching Hospital in Plzen, Plzen, Czech Republic. ferda@fnplzen.cz
authors.forename: Jiri
authors.initials: J
authors.lastname: Ferda
authors.forename: Eva
authors.initials: E
authors.lastname: Ferdova
authors.forename: Milan
authors.initials: M
authors.lastname: Hora
authors.forename: Ondrej
authors.initials: O
authors.lastname: Hes
authors.forename: Jindrich
authors.initials: J
authors.lastname: Finek
authors.forename: Ondrej
authors.initials: O
authors.lastname: Topolcan
authors.forename: Boris
authors.initials: B
authors.lastname: Kreuzberg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D060787:Neoplasm Grading; D049268:Positron-Emission Tomography; D011379:Prognosis; D019275:Radiopharmaceuticals; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG-PET/CT; Renal cell carcinoma; SUVmax; hybrid imaging; prognosis