title: Genetic analysis of attachment glycoprotein (G) gene in new genotype ON1 of human respiratory syncytial virus detected in Japan.
abstract: We studied the evolution of the G gene in the new genotype ON1 of RSV detected from patients with acute respiratory infection in Japan. Phylogenetic analyses and the evolutionary timescale were obtained by the Bayesian MCMC method. We also analyzed p-distance and positive selection sites. A new genotype ON1 emerged around 2001. The evolution rate was rapid (3.57 × 10(-3) substitutions/site per year). The p-distance was short and no positive selection site was found in the present strains. These results suggested that a new genotype ON1 of RSV-A emerged approximately10 years ago and spread to some countries with a high evolution rate.
authors.affiliation: Gunma Prefectural Institute of Public Health and Environmental Sciences, 378 Kamioki-machi, Maebashi-shi, Gunma, 371-0052.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsukagoshi
authors.forename: Hajime
authors.initials: H
authors.lastname: Yokoi
authors.forename: Miho
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Izumi
authors.initials: I
authors.lastname: Kushibuchi
authors.forename: Reiko
authors.initials: R
authors.lastname: Okamoto-Nakagawa
authors.forename: Ayako
authors.initials: A
authors.lastname: Yoshida
authors.forename: Yukio
authors.initials: Y
authors.lastname: Morita
authors.forename: Masahiro
authors.initials: M
authors.lastname: Noda
authors.forename: Norio
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Kazuko
authors.initials: K
authors.lastname: Sugai
authors.forename: Kazunori
authors.initials: K
authors.lastname: Oishi
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Kozawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Kuroda
authors.forename: Komei
authors.initials: K
authors.lastname: Shirabe
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kimura
mesh_terms: D000595:Amino Acid Sequence; D019143:Evolution, Molecular; D005838:Genotype; D006801:Humans; D007564:Japan; D008969:Molecular Sequence Data; D010802:Phylogeny; D018357:Respiratory Syncytial Virus Infections / Q000821:virology*; D018113:Respiratory Syncytial Virus, Human / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D016415:Sequence Alignment; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000235:genetics*
chemical_list: D014759:Viral Envelope Proteins
keywords: genotype ON1; human respiratory syncytial virus (RSV); phylogenetic analysis