title: Studies of asymmetric styrene cyclopropanation with a rhodium(II) metallopeptide catalyst developed with a high-throughput screen.
abstract: Dirhodium metallopeptides have been developed as selective catalysts for asymmetric cyclopropanation reactions. A selective ligand sequence has been identified by screening on-bead metallopeptide libraries in a 96-well plate format. Efficient ligand synthesis and screening allows a 200-member library to be created and assayed in less than three weeks. These metallopeptides catalyze efficient cyclopropanation of aryldiazoacetates, providing asymmetric access to cyclopropane products in high diastereoselectivity.
authors.affiliation: Department of Chemistry MS60, Rice University, 6100 Main Street, Houston, TX 77005, USA.
authors.forename: Ramya
authors.initials: R
authors.lastname: Sambasivan
authors.forename: Zachary T
authors.initials: ZT
authors.lastname: Ball
mesh_terms: D002384:Catalysis; D003521:Cyclopropanes / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D008024:Ligands; D015394:Molecular Structure; D019151:Peptide Library; D012238:Rhodium / Q000737:chemistry*; D020058:Styrene / Q000737:chemistry*
chemical_list: D003521:Cyclopropanes; D008024:Ligands; D019151:Peptide Library; D020058:Styrene; C030797:cyclopropane; D012238:Rhodium
keywords: asymmetric catalysis; catalyst screening; cyclopropanation; metallopeptides; peptide library; rhodium