title: Chronic valproic acid intoxication.
abstract: Valproic acid intoxication may be associated with cerebral, cardiovascular, respiratory, gastrointestinal, and hematologic complications. We report a case of a 7-year-old girl, epilepsy-treated chronically with valproic acid, sulthiame, and clonazepam, who presented to the emergency room because of a global deterioration during the preceding 2 months, including poorer feeding and worsened general responsiveness. The girl was later diagnosed to have chronic valproic acid intoxication.
authors.affiliation: Department of Pediatrics, Hillel-Yaffe Medical Center, Hadera, Israel.
authors.forename: Dror
authors.initials: D
authors.lastname: Weiner
authors.forename: Vered
authors.initials: V
authors.lastname: Nir
authors.forename: Adi
authors.initials: A
authors.lastname: Klein-Kremer
authors.forename: Eiass
authors.initials: E
authors.lastname: Kassem
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000506:poisoning*; D002547:Cerebral Palsy / Q000150:complications; D002626:Chemistry, Pharmaceutical; D002648:Child; D002908:Chronic Disease; D002658:Developmental Disabilities / Q000150:complications; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose / Q000209:etiology*; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D053609:Lethargy / Q000139:chemically induced*; D008508:Medication Errors; D011782:Quadriplegia / Q000150:complications; D013921:Thrombocytopenia / Q000139:chemically induced; D014635:Valproic Acid / Q000008:administration & dosage / Q000506:poisoning*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid