title: Metformin, microbes, and aging.
abstract: The mechanisms underlying the biological activity of metformin, a widely prescribed drug to treat type 2 diabetes, remain elusive. In a recent issue of Cell, Cabreiro et al. report that in C. elegans, metformin indirectly impacts lifespan by altering the methionine metabolism of its microbial partner E. coli (Cabreiro et al., 2013).
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, CNRS UMR 5242, Université Claude Bernard Lyon-1, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Storelli
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, CNRS UMR 5242, Université Claude Bernard Lyon-1, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
authors.forename: Mélisandre
authors.initials: M
authors.lastname: Téfit
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, CNRS UMR 5242, Université Claude Bernard Lyon-1, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. Electronic address: francois.leulier@ens-lyon.fr.
authors.forename: François
authors.initials: F
authors.lastname: Leulier
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000382:microbiology*; D005492:Folic Acid / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008136:Longevity / Q000187:drug effects*; D008687:Metformin / Q000494:pharmacology*; D008715:Methionine / Q000378:metabolism*
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin; D005492:Folic Acid; D008715:Methionine