title: Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: the Hisayama Study.
abstract: BACKGROUND
  Angiopoietin-like protein 2 (Angptl2) is an adipokine that promotes inflammation and endothelial dysfunction of the vessels. The aim of this study was to investigate the relationship between serum Angptl2 level and chronic kidney disease (CKD).
  
  
  RESULTS
  A total of 3,169 community-dwelling subjects aged ≥40 years were divided into quintiles by Angptl2 level. CKD was defined as the presence of albuminuria (urine albumin-creatinine ratio ≥30.0mg/g) or decreased estimated glomerular filtration rate (eGFR <60ml·min(-1)·1.73m(-2)). The odds ratio (OR) for the presence of CKD was calculated using a logistic regression model. The overall prevalence of CKD was 37.5%. The age- and sex-adjusted ORs for the presence of CKD increased with higher serum Angptl2 level. This trend remained significant after adjusting for known cardiovascular risk factors (<2.01ng/ml: OR, 1.00 (reference); 2.01-2.48ng/ml: OR, 1.67, 95% confidence interval [CI]: 1.24-2.24; 2.49-2.99ng/ml: OR, 1.70, 95% CI: 1.27-2.28; 3.00-3.65ng/ml: OR, 1.78, 95% CI: 1.32-2.39; ≥3.66ng/ml: OR, 1.79, 95% CI: 1.32-2.43; P-value for trend=0.001). Multivariate-adjusted ORs for the presence of albuminuria increased significantly with elevated serum Angptl2 (P-value for trend=0.004), while there was no evidence of a significant relationship between serum Angptl2 level and decreased eGFR (P-value for trend=0.08).
  
  
  CONCLUSIONS
  Elevated serum Angptl2 is associated with the likelihood of CKD in the general population.
authors.affiliation: Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Usui
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Ninomiya
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nagata
authors.forename: Otowa
authors.initials: O
authors.lastname: Takahashi
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Doi
authors.forename: Jun
authors.initials: J
authors.lastname: Hata
authors.forename: Masayo
authors.initials: M
authors.lastname: Fukuhara
authors.forename: Takanari
authors.initials: T
authors.lastname: Kitazono
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oike
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kiyohara
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000097:blood / Q000150:complications / Q000453:epidemiology; D000091302:Angiopoietin-Like Protein 2; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins / Q000097:blood*; D044466:Asian People; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D012307:Risk Factors
chemical_list: C485792:ANGPTL2 protein, human; D000091302:Angiopoietin-Like Protein 2; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins