title: Recommendations for the management of candidemia in neonates in Latin America. Latin America Invasive Mycosis Network.
abstract: Candidemia is one of the most frequent opportunistic mycoses worldwide. Limited epidemiological studies in Latin America indicate that incidence rates are higher in this region than in the Northern Hemisphere. Diagnosis is often made late in the infection, affecting the initiation of antifungal therapy. A more scientific approach, based on specific parameters, for diagnosis and management of candidemia in Latin America is warranted. 'Recommendations for the diagnosis and management of candidemia' are a series of manuscripts that have been developed by members of the Latin America Invasive Mycosis Network. They aim to provide a set of best-evidence recommendations for the diagnosis and management of candidemia. This publication, 'Recommendations for the management of candidemia in neonates in Latin America', was written to provide guidance to healthcare professionals on the management of neonates who have, or who are at risk of, candidemia. Computerized searches of existing literature were performed by PubMed. The data were extensively reviewed and analyzed by members of the group. The group also met on two occasions to pose questions, discuss conflicting views, and deliberate on a series of management recommendations. 'Recommendations for the management of candidemia in neonates in Latin America' includes prophylaxis, empirical therapy, therapy for proven candidemia, patient work-up following diagnosis of candidemia, central venous catheter management, and management of complications. This manuscript is the fourth of this series that deals with diagnosis and treatment of invasive candidiasis. Other publications in this series include: 'Recommendations for the diagnosis of candidemia in Latin America', 'Recommendations for the management of candidemia in adults in Latin America', and 'Recommendations for the management of candidemia in children in Latin America'.
authors.affiliation: Hospital Luis Calvo Mackenna, Universidad de Chile, Santiago, Chile; Latin America Invasive Mycosis Network. Electronic address: msantola@med.uchile.cl.
authors.forename: María E
authors.initials: ME
authors.lastname: Santolaya
authors.forename: Tito
authors.initials: T
authors.lastname: Alvarado Matute
authors.forename: Flavio
authors.initials: F
authors.lastname: de Queiroz Telles
authors.forename: Arnaldo Lopes
authors.initials: AL
authors.lastname: Colombo
authors.forename: Jeannete
authors.initials: J
authors.lastname: Zurita
authors.forename: Iris Nora
authors.initials: IN
authors.lastname: Tiraboschi
authors.forename: Jorge Alberto
authors.initials: JA
authors.lastname: Cortes
authors.forename: Luis
authors.initials: L
authors.lastname: Thompson-Moya
authors.forename: Manuel
authors.initials: M
authors.lastname: Guzman-Blanco
authors.forename: Jose
authors.initials: J
authors.lastname: Sifuentes
authors.forename: Juan
authors.initials: J
authors.lastname: Echevarría
authors.forename: Marcio
authors.initials: M
authors.lastname: Nucci
mesh_terms: D000465:Algorithms; D000935:Antifungal Agents / Q000627:therapeutic use; D001925:Brain Damage, Chronic / Q000209:etiology / Q000517:prevention & control; D002175:Candida / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D058387:Candidemia / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D058365:Candidiasis, Invasive / Q000188:drug therapy; D055499:Catheter-Related Infections / Q000382:microbiology / Q000517:prevention & control; D003428:Cross Infection / Q000517:prevention & control; D019468:Disease Management; D004198:Disease Susceptibility; D025141:Drug Resistance, Fungal; D006801:Humans; D016867:Immunocompromised Host; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy; D007843:Latin America; D012307:Risk Factors
chemical_list: D000935:Antifungal Agents
keywords: América Latina; Candidemia; Latin America; Management; Manejo; Neonates; Neonatos; Recomendaciones; Recommendations