title: Evasion of adaptive and innate immune response mechanisms by γ-herpesviruses.
abstract: γ-Herpesviral immune evasion mechanisms are optimized to support the acute, lytic and the longterm, latent phase of infection. During acute infection, specific immune modulatory proteins limit, but also exploit, the antiviral activities of cell intrinsic innate immune responses as well as those of innate and adaptive immune cells. During latent infection, a restricted gene expression program limits immune targeting and cis-acting mechanisms to reduce the antigen presentation as well as antigenicity of latency-associated proteins. Here, we will review recent progress in our understanding of γ-herpesviral immune evasion strategies.
authors.affiliation: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Pinghui
authors.initials: P
authors.lastname: Feng
authors.forename: Ashlee
authors.initials: A
authors.lastname: Moses
authors.forename: Klaus
authors.initials: K
authors.lastname: Früh
mesh_terms: D018142:Gammaherpesvirinae / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D017735:Virus Latency