title: Outcome of pregnancy in Italian patients with primary Sjögren syndrome.
abstract: OBJECTIVE
  To investigate pregnancy and fetal outcomes in patients with primary Sjögren syndrome (pSS).
  
  
  METHODS
  An obstetric history of 36 women with established diagnosis of pSS at pregnancy was obtained from a multicenter cohort of 1075 patients. In a subgroup case-control analysis, 12 deliveries in patients with pSS were compared with 96 control deliveries.
  
  
  RESULTS
  Thirty-six women (31 with anti-SSA/Ro and/or anti-SSB/La antibodies) with an established diagnosis of pSS had 45 pregnancies with the delivery of 40 newborns. Two miscarriages, 2 fetal deaths, and 1 induced abortion were recorded. Mean age at the first pregnancy was 33.9 years; mean number of pregnancies was 1.25; 18/40 (45%) cesarean births were delivered; mean pregnancy length was 38.5 weeks (range 32-43), with 6 preterm deliveries. The mean Apgar score at 5 min was 8.9, mean birthweight was 2920 g (range 826-4060 g). Congenital heart block (CHB) occurred in 2/40 (5%) newborns. The reported rate of breastfeeding for at least 1 month was 60.5%. In 4/40 pregnancies (10%) a flare of disease activity was observed within a year from delivery. In the case-control subgroup analysis, 12 deliveries were compared with 96 controls and no significant differences were found.
  
  
  CONCLUSIONS
  Patients with pSS can have successful pregnancies, which might be followed by a mild relapse. CHB was the only cause of death for offspring of mothers with pSS.
authors.affiliation: Rheumatology Unit and Department of Gynecology and Obstetrics, Sapienza University, Rome, Italy. roberta.priori63@gmail.com
authors.forename: Roberta
authors.initials: R
authors.lastname: Priori
authors.forename: Angelica
authors.initials: A
authors.lastname: Gattamelata
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Modesti
authors.forename: Serena
authors.initials: S
authors.lastname: Colafrancesco
authors.forename: Silvia
authors.initials: S
authors.lastname: Frisenda
authors.forename: Antonina
authors.initials: A
authors.lastname: Minniti
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Framarino-dei-Malatesta
authors.forename: Marta
authors.initials: M
authors.lastname: Maset
authors.forename: Luca
authors.initials: L
authors.lastname: Quartuccio
authors.forename: Salvatore
authors.initials: S
authors.lastname: De Vita
authors.forename: Elena
authors.initials: E
authors.lastname: Bartoloni
authors.forename: Alessia
authors.initials: A
authors.lastname: Alunno
authors.forename: Roberto
authors.initials: R
authors.lastname: Gerli
authors.forename: Francesca
authors.initials: F
authors.lastname: Strigini
authors.forename: Chiara
authors.initials: C
authors.lastname: Baldini
authors.forename: Chiara
authors.initials: C
authors.lastname: Tani
authors.forename: Marta
authors.initials: M
authors.lastname: Mosca
authors.forename: Stefano
authors.initials: S
authors.lastname: Bombardieri
authors.forename: Guido
authors.initials: G
authors.lastname: Valesini
mesh_terms: D000328:Adult; D001724:Birth Weight; D005260:Female; D005313:Fetal Death; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007558:Italy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology* / Q000503:physiopathology; D011256:Pregnancy Outcome; D012859:Sjogren's Syndrome / Q000276:immunology* / Q000503:physiopathology
keywords: ABORTION; ANTI-RO/LA ANTIBODIES; NEONATAL LUPUS; PREGNANCY; SJÖGREN SYNDROME