title: Evaluation of WGA and Concanavalin A (Con A) lectin as biomarkers of hepatosplenic schistosomiasis in human biopsies with no evidence of egg-granuloma system.
abstract: BACKGROUND
  Colonic lesions are predominant in patients with schistosomiasis. However, carbohydrate alterations in colonic schistosomiasis remain unclear. Lectin-ligands allow us to identify changes in the saccharide patterns of cells.
  
  
  METHODS
  Biopsies of descending and rectosigmoid colon of patients were submitted to WGA and Con A lectin histochemistry.
  
  
  RESULTS
  WGA stained stroma and gland cells of descending colon and rectosigmoid tissues in a granular strong cytoplasmatic pattern in schistosomiasis specimens differing from normal control and Con A failing to recognize all samples analyzed.
  
  
  CONCLUSIONS
  WGA ligands are expressed differently in patients with hepatosplenic schistosomiasis and no evidence of egg-granuloma system.
authors.affiliation: Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, PE, Brazil.
authors.forename: Moacyr Jesus Barreto de Melo
authors.initials: MJ
authors.lastname: Rêgo
authors.forename: Gabriela Souto
authors.initials: GS
authors.lastname: Vieira-De-Mello
authors.forename: Cláudio Witaker
authors.initials: CW
authors.lastname: Araújo
authors.forename: Maria do Socorro de Mendonça
authors.initials: Mdo S
authors.lastname: Cavalcanti
authors.forename: Eduardo Isidoro Carneiro
authors.initials: EI
authors.lastname: Beltrão
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D012809:Colon, Sigmoid / Q000737:chemistry* / Q000469:parasitology / Q000473:pathology; D003208:Concanavalin A / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D012555:Schistosomiasis mansoni / Q000378:metabolism* / Q000473:pathology; D013158:Splenic Diseases / Q000378:metabolism* / Q000469:parasitology / Q000473:pathology; D014909:Wheat Germ Agglutinins / Q000032:analysis*
chemical_list: D015415:Biomarkers; D014909:Wheat Germ Agglutinins; D003208:Concanavalin A