title: Tissue engineering for skeletal muscle regeneration.
abstract: Stem cells and regenerative medicine have obtained a remarkable consent from the scientific community for their promising ability to recover aged, injured and diseased tissue. However, despite the noteworthy potential, hurdles currently hinder their use and clinical application: cell survival, immune response, tissue engraftment and efficient differentiation. Hence a new interdisciplinary scientific approach, such as tissue engineering, is going deep attempts to mimic neo-tissue-genesis as well as stem cell engraftment amelioration. Skeletal muscle tissue engineering represents a great potentiality in medicine for muscle regeneration exploiting new generation injectable hydrogel as scaffold supporting progenitor/stem cells for muscle differentiation reconstructing the natural skeletal muscle tissue architecture influenced by matrix mechanical and physical property and by a dynamic environment.
authors.affiliation: IRCCS MultiMedica, Milan, Italy ; Cell Biology and Neurobiology Institute, National Research Council of Italy, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Rizzi
authors.forename: Claudia
authors.initials: C
authors.lastname: Bearzi
authors.forename: Arianna
authors.initials: A
authors.lastname: Mauretti
authors.forename: Sergio
authors.initials: S
authors.lastname: Bernardini
authors.forename: Stefano
authors.initials: S
authors.lastname: Cannata
authors.forename: Cesare
authors.initials: C
authors.lastname: Gargioli
keywords: hydrogel; mesoangioblast; skeletal muscle; stem cell; tissue engineering