title: Neurologic complications following pediatric renal transplantation.
abstract: We reviewed neurologic complications after renal transplantation in children over a 20-year period. Neurologic complications were classified as early (within 3 months) and delayed (beyond 3 months). Of 115 children, 10 (8.7%) had complications. Early complications were found in 4.35% of patients: seizures in 4 (posterior reversible leukoencephalopathy syndrome due to immunosuppressant toxicity, sepsis/presumed meningitis, and indeterminate) and headaches in 1. One patient with seizures received levetiracetam for 6 months and 1 with headaches received amitriptyline prophylaxis. Late complications were noted in 4.35% of patients: seizures in 3 (posterior reversible leukoencephalopathy syndrome due to hypertension, hypertensive encephalopathy), headaches in 2, and tremors in 1. Two patients with seizures were treated with anti-epilepsy medications; 1 with migraine received cyproheptadine prophylaxis. Neurologic complications develop in children after renal transplantation. Seizures due to posterior reversible leukoencephalopathy syndrome were the commonest complication. Early detection and appropriate management of these complications is important.
authors.affiliation: Pediatric Neurology Center, Children's Hospital, Cleveland Clinic, Cleveland, OH, USA Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Partha S
authors.initials: PS
authors.lastname: Ghosh
authors.affiliation: Department of Nephrology, Children's Hospital, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Kwon
authors.affiliation: Department of Nephrology, Children's Hospital, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Melanie
authors.initials: M
authors.lastname: Klein
authors.affiliation: Department of Nephrology, Children's Hospital, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Corder
authors.affiliation: Pediatric Neurology Center, Children's Hospital, Cleveland Clinic, Cleveland, OH, USA ghoshd2@ccf.org.
authors.forename: Debabrata
authors.initials: D
authors.lastname: Ghosh
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology; D002648:Child; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008137:Longitudinal Studies; D008297:Male; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology*; D059906:Neuroimaging; D009460:Neurologic Examination; D012189:Retrospective Studies; D055815:Young Adult
keywords: children; neurologic complications; posterior reversible leukoencephalopathy; renal transplantation