title: Redox processes in neurodegenerative disease involving reactive oxygen species.
abstract: Much attention has been devoted to neurodegenerative diseases involving redox processes. This review comprises an update involving redox processes reported in the considerable literature in recent years. The mechanism involves reactive oxygen species and oxidative stress, usually in the brain. There are many examples including Parkinson's, Huntington's, Alzheimer's, prions, Down's syndrome, ataxia, multiple sclerosis, Creutzfeldt-Jacob disease, amyotrophic lateral sclerosis, schizophrenia, and Tardive Dyskinesia. Evidence indicates a protective role for antioxidants, which may have clinical implications. A multifaceted approach to mode of action appears reasonable.
authors.affiliation: Department of Chemistry and Biochemistry, San Diego State University, San Diego CA 92182 USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Kovacic
authors.forename: Ratnasamy
authors.initials: R
authors.lastname: Somanathan
keywords: Redox; neurodegenerative diseases; oxidative stress.; reactive oxygen species