title: Oral branched-chain amino acids have a beneficial effect on manifestations of hepatic encephalopathy in a systematic review with meta-analyses of randomized controlled trials.
abstract: Supplements with branched-chain amino acid (BCAA) have cerebral, metabolic, and nutritional effects that may benefit patients with hepatic encephalopathy (HE). We therefore conducted a systematic review on the effects of oral BCAAs compared with control supplements or placebo for patients with cirrhosis and recurrent overt or minimal HE. The quantitative analyses included data from 8 trials (n = 382 patients). Individual patient data were retrieved from 4 trials to recalculate outcomes (n = 255 patients). The mean dose of the oral BCAA supplements was 0.25 g/(kg body weight · d). Random effects meta-analysis showed that improvements in HE manifestations were registered for 87 of 172 patients in the BCAA group compared with 56 of 210 controls [risk ratio = 1.71 (95% CI: 1.17, 2.51) number needed to treat = 5 patients]. The effect of BCAAs differed (P = 0.04) for patients with overt [risk ratio = 3.26 (95% CI: 1.47, 7.22)] and minimal HE [risk ratio = 1.32 (95% CI: 0.97, 1.79)]. Subgroup, sensitivity, regression, and sequential analyses found no other sources of heterogeneity or bias. BCAA supplements had no effect on mortality or markers of nutritional status and did not induce adverse events. In conclusion, oral BCAA supplements improve manifestations of HE but have no effect on survival.
authors.affiliation: Department of Medicine, Copenhagen University Hospital Gentofte, Hellerup, Denmark. liselottegluud@yahoo.dk
authors.forename: Lise L
authors.initials: LL
authors.lastname: Gluud
authors.forename: Gitte
authors.initials: G
authors.lastname: Dam
authors.forename: Mette
authors.initials: M
authors.lastname: Borre
authors.forename: Iñigo
authors.initials: I
authors.lastname: Les
authors.forename: Juan
authors.initials: J
authors.lastname: Cordoba
authors.forename: Giulio
authors.initials: G
authors.lastname: Marchesini
authors.forename: Niels K
authors.initials: NK
authors.lastname: Aagaard
authors.forename: Niels
authors.initials: N
authors.lastname: Risum
authors.forename: Hendrik
authors.initials: H
authors.lastname: Vilstrup
mesh_terms: D000284:Administration, Oral; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D019587:Dietary Supplements; D006501:Hepatic Encephalopathy / Q000188:drug therapy*; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic
chemical_list: D000597:Amino Acids, Branched-Chain