title: Dendritic and lymphocytic cell infiltration in prostate carcinoma.
abstract: We examined the distribution of CD1a⁺ cells and CD8⁺ and CD4⁺ T lymphocytes in prostate cancer (PCa) and correlated these with clinicopathological parameters. We also investigated whether the distribution of these cells was related to the expression of the cell membrane protein B7-H3, a putative negative regulator of the immune response expressed on PCa cells. A cohort of 151 PCa patients treated with radical prostatectomy (RP) was followed prospectively from 1985 until 2006 with a median follow-up of 9 years. Whole-mount sections of PCa specimens were immunostained to identify immune cells. A low number of CD1a⁺ cells was significantly associated with a high Gleason score and high pathological stage of pT3. The number of CD1a⁺ cells correlated significantly with the number of intratumoral and stromal CD8⁺ and stromal CD4⁺ lymphocytes. Kaplan-Meier analysis showed a tendency toward impaired biochemical progression-free survival in patients with few CD1a⁺ cells within their RP specimens. The expression of B7-H3 correlated inversely with the number of CD1a⁺ cells and intratumoral CD4⁺ lymphocytes; there was a trend for a similar inverse relationship between B7-H3 expression and the number of CD8⁺ lymphocytes.
authors.affiliation: Department of Urology, The Norwegian Radium Hospital, Oslo University Hospital, and Department of Urology, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Yishan
authors.initials: Y
authors.lastname: Liu
authors.forename: Thorstein
authors.initials: T
authors.lastname: Sæter
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Vlatkovic
authors.forename: Einar
authors.initials: E
authors.lastname: Servoll
authors.forename: Gudmund
authors.initials: G
authors.lastname: Waaler
authors.forename: Ulrika
authors.initials: U
authors.lastname: Axcrona
authors.forename: Karl-Erik
authors.initials: KE
authors.lastname: Giercksky
authors.forename: Jahn M
authors.initials: JM
authors.lastname: Nesland
authors.forename: Zhen-He
authors.initials: ZH
authors.lastname: Suo
authors.forename: Karol
authors.initials: K
authors.lastname: Axcrona
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D018572:Disease-Free Survival; D006801:Humans; D007157:Immunologic Surveillance / Q000276:immunology; D053208:Kaplan-Meier Estimate; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000401:mortality / Q000473:pathology