title: Common biomarkers of oxidative stress do not reflect cardiovascular dys/function in rats.
abstract: BACKGROUND
  Predicting cardiovascular events remains challenging despite the range of known biomarkers.
  
  
  OBJECTIVE
  To establish relationships between various biochemical and functional parameters of the cardiovascular system.
  
  
  METHODS
  The relationship between cardiovascular dys/function and various biomarkers was examined in 145 experimental rats half of which received isoprenaline 100 mg/kg s.c. to induce cardiac impairment.
  
  
  RESULTS
  Serum concentration of cardiac troponin T (cTnT), a known marker of cardiac derangement, correlated strongly with degree of myocardial injury (e.g. calcium overload, stroke volume) but correlations between cTnT and oxidative stress parameters were weak (for glutathione and vitamin C) or not found (for serum vitamin E and plasma thiobarbituric acid reactive substances levels). Relationships between cTnT and other parameters were exponential with the exception of myocardial calcium, where a power function was found.
  
  
  CONCLUSIONS
  Commonly used biomarkers of oxidative stress cannot reliably predict cardiovascular dys/function in experimental rats.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic. mladenkap@faf.cuni.cz
authors.forename: Premysl
authors.initials: P
authors.lastname: Mladenka
authors.forename: Libuse
authors.initials: L
authors.lastname: Zatloukalova
authors.forename: Tomas
authors.initials: T
authors.lastname: Filipsky
authors.forename: Jaroslava
authors.initials: J
authors.lastname: Vavrova
authors.forename: Magdalena
authors.initials: M
authors.lastname: Holeckova
authors.forename: Vladimir
authors.initials: V
authors.lastname: Palicka
authors.forename: Radomir
authors.initials: R
authors.lastname: Hrdina
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood / Q000503:physiopathology; D002319:Cardiovascular System / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013318:Stroke Volume; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T