title: Two new dihydrostilbenoid glycosides isolated from the leaves of Litsea coreana and their anti-inflammatory activity.
abstract: Two new dihydrostilbenoid glycosides, named 5-(2-phenylethyl)-3-hydroxyphenol-1-O-beta-D-glucopyranoside (1) and 6-(2-phenylethyl)-2,4-dihydroxy benzoic acid-2-O-beta-D-glucopyranoside (2), together with two known compounds, were isolated from the leaves of Litsea coreana Levl.. Their structures were established on the basis of NMR spectroscopic, MS and chemical data. Biological tests revealed that 1-3 exhibited moderate anti-inflammatory activity through an inhibitory effect on TNF-alpha, IL-1 production from RAW264.7 cell line activated with lipopolysaccharides (LPS).
authors.affiliation: School of Pharmacy, Anhui Medical University, Hefei 230032, China.
authors.forename: Wenjian
authors.initials: W
authors.lastname: Tang
authors.forename: Weili
authors.initials: W
authors.lastname: Lu
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Cao
authors.forename: Yilong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Xiongwen
authors.initials: X
authors.lastname: Lv
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification*; D002478:Cells, Cultured; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D032862:Litsea / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: C582751:5-(2-phenylethyl)-3-hydroxyphenol-1-O-beta-D-glucopyranoside; C582752:6-(2-phenylethyl)-2,4-dihydroxy benzoic acid-2-O-beta-D-glucopyranoside; D000893:Anti-Inflammatory Agents; D005960:Glucosides; D013267:Stilbenes