title: The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line.
abstract: Natural and synthetic derivatives of benzo-γ-pyrones (i.e. flavones, chromones, and coumarins) and their synthetic analogues possess a wide range of biological properties in vitro and in vivo. In this paper we investigated the influence of two hydrazone compounds of chromones, 3-{[(2-dimethoxytiophosphoryl)-2-methylhydrazono]-methyl}-chromen-4-one (CH-3) and 2-amino-6-chloro-3-[(2-hydroxyethyl)-hydrazonomethyl]-chromen-4-one (A-12), on lipid peroxidation and bFGF concentration in the HL-60 cells. Both of the studied compounds had a significant influence on bFGF and TBARS in ranges -137.20 ~ 380.26% and -81.66 ~ -28.68%, respectively, in comparison with the control (counted as 0%).
authors.affiliation: Department of Bioinorganic Chemistry, Faculty of Pharmacy, Medical University of Lodz, Łódź, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Łazarenkow
authors.forename: Marta
authors.initials: M
authors.lastname: Michalska
authors.forename: Anna
authors.initials: A
authors.lastname: Gorąca
authors.forename: Marek
authors.initials: M
authors.lastname: Mirowski
authors.forename: Jolanta
authors.initials: J
authors.lastname: Nawrot-Modranka
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Piechota-Polanczyk
mesh_terms: D002867:Chromones / Q000494:pharmacology*; D016222:Fibroblast Growth Factor 2 / Q000187:drug effects* / Q000378:metabolism; D018922:HL-60 Cells; D006801:Humans; D006835:Hydrazones / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D002867:Chromones; D006835:Hydrazones; D017392:Thiobarbituric Acid Reactive Substances; D016222:Fibroblast Growth Factor 2