title: Adsorption properties of biologically active derivatives of quaternary ammonium surfactants and their mixtures at aqueous/air interface. I. Equilibrium surface tension, surfactant aggregation and wettability.
abstract: The adsorption properties of surfactant mixtures containing two types of quaternary derivatives of lysosomotropic substances: alkyl N,N-dimethylalaninates methobromides and alkyl N,N-dimethylglycinates methobromides were studied. Quantitative and qualitative description of the adsorption process was carried out on the basis of experimentally obtained equilibrium surface tension isotherms. The results indicated that most of the systems studied revealed synergistic effect both in adsorption and wetting properties. In vitro studies on human cancer cells were undertaken and the data obtained showed that the mixtures suppressed the cancer cells' proliferation more effectively than individual components. Results of preliminary research on the interaction of catanionic mixtures with phospholipids suggested a possibility of a strong penetration of cell membranes by the mixtures investigated.
authors.affiliation: Poznan University of Technology, Institute of Chemical Technology and Engineering, Pl. M. Skłodowskiej-Curie 2, 60-965 Poznań, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Rojewska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Biadasz
authors.forename: Michał
authors.initials: M
authors.lastname: Kotkowiak
authors.forename: Anna
authors.initials: A
authors.lastname: Olejnik
authors.forename: Joanna
authors.initials: J
authors.lastname: Rychlik
authors.forename: Alina
authors.initials: A
authors.lastname: Dudkowiak
authors.forename: Krystyna
authors.initials: K
authors.lastname: Prochaska
mesh_terms: D000327:Adsorption; D000388:Air; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D018938:Caco-2 Cells; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013500:Surface Tension; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology*; D014867:Water / Q000737:chemistry; D017155:Wettability
chemical_list: D000970:Antineoplastic Agents; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; D014867:Water