title: Antipathogenic potential of Rhizophora spp. against the quorum sensing mediated virulence factors production in drug resistant Pseudomonas aeruginosa.
abstract: Quorum sensing (QS) is a process of cell-cell communication mechanism occurs between the bacterial cells through the secretary signal molecules. This QS mechanism has been shown to control over the expression of various genes responsible for the production of virulence factors in several bacterial pathogens. Hence, the present study was intended to evaluate the antipathogenic potential of mangrove trees of the genus Rhizophora against the QS dependent virulence factors production in Pseudomonas aeruginosa PAO1, clinical isolates CI-I (GU447237) and CI-II (GU447238). The methanol extract of Rhizophora apiculata and R. mucronata (1 mg/ml) showed significant inhibition against QS dependent virulence factors production such as LasA protease, LasB elastase, total protease, pyocyanin pigment production and biofilm formation in P. aeruginosa PAO1, CI-I and CI-II. This study for the first time, reports the quorum sensing inhibitory (QSI) potential of Rhizophora spp. against P. aeruginosa infections.
authors.affiliation: Department of Biotechnology, Alagappa University, Karaikudi 630003, Tamil Nadu, India.
authors.forename: Angusamy
authors.initials: A
authors.lastname: Annapoorani
authors.forename: Balaji
authors.initials: B
authors.lastname: Kalpana
authors.forename: Khadar Syed
authors.initials: KS
authors.lastname: Musthafa
authors.forename: Shunmugiah Karutha
authors.initials: SK
authors.lastname: Pandian
authors.forename: Arumugam Veera
authors.initials: AV
authors.lastname: Ravi
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018441:Biofilms / Q000187:drug effects; D004351:Drug Resistance / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D053038:Quorum Sensing / Q000187:drug effects*; D043982:Rhizophoraceae; D013045:Species Specificity; D037521:Virulence Factors / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts; D037521:Virulence Factors
keywords: Pseudomonas aeruginosa; Quorum sensing; Quorum sensing inhibition; Rhizophora; Virulence