title: Low cerebrospinal fluid pressure in the pathogenesis of primary open-angle glaucoma: epiphenomenon or causal relationship? The Beijing Intracranial and Intraocular Pressure (iCOP) study.
abstract: Previous experimental and clinical investigations have suggested that some patients with primary open-angle glaucoma may have an abnormally low orbital cerebrospinal fluid pressure (CSFP). A meta-analysis of available clinical data showed a marked overlap in lumbar CSFP measurements between patients with normal-tension glaucoma and healthy subjects, so that the question arises as to which additional factors play a role in the pathogenesis of glaucomatous optic neuropathy.
authors.affiliation: Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing, China.
authors.forename: Ningli
authors.initials: N
authors.lastname: Wang
authors.forename: Diya
authors.initials: D
authors.lastname: Yang
authors.forename: Jost B
authors.initials: JB
authors.lastname: Jonas
mesh_terms: D015170:Cerebrospinal Fluid Pressure / Q000502:physiology*; D005902:Glaucoma, Open-Angle / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure