title: Negative aspects of close relationships are more strongly associated than supportive personal relationships with illness burden of irritable bowel syndrome.
abstract: OBJECTIVE
  This study assessed the relative magnitude of associations between IBS outcomes and different aspects of social relationships (social support, negative interactions).
  
  
  METHODS
  Subjects included 235 Rome III diagnosed IBS patients (M age=41yrs, F=78%) without comorbid GI disease. Subjects completed a testing battery that included the Interpersonal Support Evaluation List (Social Support or SS), Negative Interaction (NI) Scale, IBS Symptom Severity Scale (IBS-SSS), IBS-QOL, BSI Depression, STAI Trait Anxiety, SOMS-7 (somatization), Perceived Stress Scale, and a medical comorbidity checklist.
  
  
  RESULTS
  After controlling for demographic variables, both SS and NI were significantly correlated with all of the clinical variables (SS r's=.20 to .36; NI r's=.17 to .53, respectively; ps<.05) save for IBS symptom severity (IBS-SSS). NI, but not SS, was positively correlated with IBS-SSS. After performing r-to-z transformations on the correlation coefficients and then comparing z-scores, the correlation between perceived stress, and NI was significantly stronger than with SS. There was no significant difference between the strength of correlations between NI and SS for depression, somatization, trait anxiety, and IBSQOL. A hierarchical linear regression identified both SS and NI as significant predictors of IBS-QOL.
  
  
  CONCLUSIONS
  Different aspects of social relationships - support and negative interactions - are associated with multiple aspects of IBS experience (e.g. stress, QOL impairment). Negative social relationships marked by conflict and adverse exchanges are more consistently and strongly related to IBS outcomes than social support.
authors.affiliation: Department of Medicine, University at Buffalo School of Medicine, SUNY, Buffalo, NY 14215, United States. lackner@buffalo.edu
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Lackner
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Gudleski
authors.forename: Rebecca
authors.initials: R
authors.lastname: Firth
authors.forename: Laurie
authors.initials: L
authors.lastname: Keefer
authors.forename: Darren M
authors.initials: DM
authors.lastname: Brenner
authors.forename: Katie
authors.initials: K
authors.lastname: Guy
authors.forename: Camille
authors.initials: C
authors.lastname: Simonetti
authors.forename: Christopher
authors.initials: C
authors.lastname: Radziwon
authors.forename: Sarah
authors.initials: S
authors.lastname: Quinton
authors.forename: Susan S
authors.initials: SS
authors.lastname: Krasner
authors.forename: Leonard
authors.initials: L
authors.lastname: Katz
authors.forename: Guido
authors.initials: G
authors.lastname: Garbarino
authors.forename: Gary D
authors.initials: GD
authors.lastname: Iacobucci
authors.forename: Michael D
authors.initials: MD
authors.lastname: Sitrin
mesh_terms: D015746:Abdominal Pain / Q000523:psychology; D000223:Adaptation, Psychological; D000328:Adult; D001007:Anxiety / Q000523:psychology; D017281:Cost of Illness; D004644:Emotions; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D043183:Irritable Bowel Syndrome / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D012944:Social Support; D011795:Surveys and Questionnaires