title: Cytotoxicity of meroterpenoids from Sargassum siliquastrum against human cancer cells.
abstract: The cytotoxicity of the brown alga Sargassum siliquastrum on human cancer cells (AGS, HT-29, HT-1080, and MCF-7) was investigated. Bioassay-guided fractionation of the crude extracts showed that the 85% aq. methanol (MeOH) fraction was the most toxic. Seven known meroterpenoids (1-7) were isolated from this cytotoxic fraction. Each compound was evaluated for its cytotoxic effect on human cancer cells. Compounds 1, 2, and 4 showed strong cytotoxicity against AGS, HT-29, and HT-1080 cell lines, with IC50 values ranging from 0.5 to 5.7 microg/mL.
authors.affiliation: Food and Safety Research Center, National Fisheries Research & Development Institute, Busan 619-705, Republic of Korea.
authors.forename: Jung Im
authors.initials: JI
authors.lastname: Lee
authors.forename: Myoung K
authors.initials: MK
authors.lastname: Kwak
authors.forename: Hee Y
authors.initials: HY
authors.lastname: Park
authors.forename: Youngwan
authors.initials: Y
authors.lastname: Seo
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology; D044647:Sargassum / Q000737:chemistry*; D013729:Terpenes / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D013729:Terpenes