title: Echocardiography and right ventricular function in NKF stage III cronic kidney disease: Ultrasound nephrologists' role.
abstract: TAPSE measurement during echocardiography is a well known measure of right heart systo-diastolic function. Low TAPSE means reduced cranio-caudal excursion of tricuspidal annulus, sign of both reduced ejection fraction and reduced distensibility of right ventricle. It is a good prognostic index for cardiac mortality risk in CHF patients, adding significant prognostic information to NYHA stadiation. Nephrologists do not always fully aware of right ventricular function in their patients affected by chronic renal failure (CRF), even if this datum is probably crucial in vascular access policy. Our study was designed to study right ventricle function and TAPSE on 202 patients affected by moderate chronic renal failure, free from overt pulmonary hypertension. TAPSE, PAPs, right chambers diameters, classical Framingham factors, estimated glomerular filtration rate were recorded. TAPSE was reduced (<23 mm) in 43% of patients enrolled, while dilated right chambers were present in 24%. PAPs exceeded 30 mmHg in 29% of patients. Echocardiographic signs of left ventricular hypertrophy were found in 36% of patients. The ejection fraction was normal in all patients. Statistical analysis showed a significant indirect correlation between TAPSE and PAPs and between TAPSE and tele-diastolic diameters and volumes of the right ventricle, while a direct correlation was observed between TAPSE and Framingham score. TAPSE showed a bimodal distribution, with a subpopulation "low TAPSE - high PAPs", next to a population characterized by normal values ??for both parameters. A reduction in compliance and systolic function of the right heart chambers is quite early and frequent in course of CKD, a fact that the nephrologist should take in due consideration, managing blood volume or planning vascular access for hemodialysis.
authors.affiliation: Nephrology and Dialysis Unit, San Paolo Hospital, Civitavecchia, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Floccari
authors.forename: A
authors.initials: A
authors.lastname: Granata
authors.forename: R
authors.initials: R
authors.lastname: Rivera
authors.forename: F
authors.initials: F
authors.lastname: Marrocco
authors.forename: A
authors.initials: A
authors.lastname: Santoboni
authors.forename: M
authors.initials: M
authors.lastname: Malaguti
authors.forename: S
authors.initials: S
authors.lastname: Andrulli
authors.forename: L
authors.initials: L
authors.lastname: Di Lullo
keywords: Chronic renal failure; Echocardiography; Right ventricle; TAPSE