title: Proton beam radiotherapy: report of the first patient treated at the Centro Nazionale di Adroterapia Oncologica (CNAO) [National Center of Oncologic Hadron Therapy].
abstract: Proton beam radiotherapy, an innovative treatment modality, allows delivery of high radiation doses to the target while sparing surrounding healthy structures. The Centro Nazionale di Adroterapia Oncologica (CNAO), equipped with a synchrotron and capable of using both protons and ions, initiated its clinical activity in September 2011. The first treatment of a skull base tumor with protons is reported here. The case of a 26-year-old man with an intracranial low-grade chondrosarcoma of the right petroclival junction is discussed with emphasis on technical and clinical details. Two previous surgical interventions had achieved partial removal of the tumor and the patient was treated with protons for residual disease. The prescribed dose was 70 GyE in 35 fractions of 2 GyE. Treatment was completed with minimal acute toxicity consisting of grade 1 alopecia and nausea. Nine months after treatment the disease is locally controlled. Use of high-energy protons at CNAO is a safe and effective means of treating a tumor located near critical normal structures.
authors.affiliation: Fondazione CNAO, Pavia, Italy. roberto.orecchia@cnao.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Orecchia
authors.forename: Anurita
authors.initials: A
authors.lastname: Srivastava
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Fiore
authors.forename: Viviana
authors.initials: V
authors.lastname: Vitolo
authors.forename: Piero
authors.initials: P
authors.lastname: Fossati
authors.forename: Barbara
authors.initials: B
authors.lastname: Vischioni
authors.forename: Alberto
authors.initials: A
authors.lastname: Iannalfi
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Tuan
authors.forename: Mario
authors.initials: M
authors.lastname: Ciocca
authors.forename: Silvia
authors.initials: S
authors.lastname: Molinelli
authors.forename: Alfredo
authors.initials: A
authors.lastname: Mirandola
authors.forename: Gloria
authors.initials: G
authors.lastname: Vilches
authors.forename: Andrea
authors.initials: A
authors.lastname: Mairani
authors.forename: Barbara
authors.initials: B
authors.lastname: Tagaste
authors.forename: Guido
authors.initials: G
authors.lastname: Baroni
authors.forename: Sandro
authors.initials: S
authors.lastname: Rossi
authors.forename: Marco
authors.initials: M
authors.lastname: Krengli
mesh_terms: D000328:Adult; D000505:Alopecia / Q000209:etiology; D002813:Chondrosarcoma / Q000150:complications / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D004172:Diplopia / Q000209:etiology; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009325:Nausea / Q000209:etiology; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000532:radiotherapy*; D061766:Proton Therapy; D011522:Protons / Q000009:adverse effects; D011880:Radiotherapy Planning, Computer-Assisted; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D019292:Skull Base Neoplasms / Q000150:complications / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D017356:Synchrotrons; D014057:Tomography, X-Ray Computed
chemical_list: D011522:Protons