title: Subclinical hypothyroidism and indices for metabolic syndrome in Japanese women: one-year follow-up study.
abstract: BACKGROUND
  Subclinical hypothyroidism (SCH) and metabolic syndrome (MetS) increase with age; however, their relationship remains unclear.
  
  
  OBJECTIVE
  Our objective was to investigate the relationship between SCH and indices of metabolic syndrome and follow up subjects for 1 year.
  
  
  METHODS
  Cross-sectional and longitudinal follow-up studies of cases were collected from Takasaki Hidaka Hospital between 2003 and 2007.
  
  
  METHODS
  Overall, 11 498 participants of health checkups were analyzed. The mean age was 48 ± 9 years.
  
  
  METHODS
  The relationship between SCH and indices of MetS were examined.
  
  
  RESULTS
  Serum free T4 levels were lower in women than men in most of the age groups, and the prevalence of SCH, 6.3% in women vs 3.4% in men, increased with age, reaching 14.6% in 70-year-old women. Multivariate logistic-regression analyses revealed that waist circumference and the serum triglyceride and low-density lipoprotein-cholesterol levels were significantly higher in subjects with SCH than without among women. Reflecting these findings, the adjusted odds ratio of MetS in patients with SCH was higher than in the euthyroid subjects in women with an odds ratio of 2.7 (95% confidence interval 1.1-5.6; P = .017) but not in men. Furthermore, progression from euthyroid into SCH resulted in a significant increase in the serum triglyceride levels but not low-density lipoprotein-cholesterol in women.
  
  
  CONCLUSIONS
  Japanese women exhibited a high prevalence of SCH associated with low free T4 levels. There was a strong association between SCH and several indices of metabolic syndrome in women. SCH may affect serum triglyceride levels and be a risk factor for metabolic syndrome.
authors.affiliation: Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Masanobu
authors.initials: M
authors.lastname: Yamada
authors.forename: Masako
authors.initials: M
authors.lastname: Akuzawa
authors.forename: Sumiyasu
authors.initials: S
authors.lastname: Ishii
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Masamura
authors.forename: Tetsurou
authors.initials: T
authors.lastname: Satoh
authors.forename: Koshi
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Mayumi
authors.initials: M
authors.lastname: Negishi
authors.forename: Yohnosuke
authors.initials: Y
authors.lastname: Shimomura
authors.forename: Isao
authors.initials: I
authors.lastname: Kobayashi
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Andou
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000150:complications*; D024821:Metabolic Syndrome / Q000209:etiology*; D008875:Middle Aged; D013974:Thyroxine / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D014280:Triglycerides; D013974:Thyroxine