title: Small airways diseases, excluding asthma and COPD: an overview.
abstract: This review is the summary of a workshop on small airways disease, which took place in Porquerolles, France in November 2011. The purpose of this workshop was to review the evidence on small airways (bronchiolar) involvement under various pathophysiological circumstances, excluding asthma and chronic obstructive pulmonary disease. Histopathological patterns associated with small airways disease were reviewed, including cellular and obliterative bronchiolitis. Many pathophysiological conditions have been associated with small airways disease including airway infections, connective tissue diseases and inflammatory bowel diseases, bone marrow and lung transplantation, common variable immunodeficiency disorders, diffuse panbronchiolitis, and diseases related to environmental exposures to pollutants, allergens and drugs. Pathogenesis, clinical presentation, a computed tomography scan and pulmonary function test findings are reviewed, and therapeutic options are described with the objective of providing an integrative approach to these disorders.
authors.affiliation: Service de Pneumologie, Hôpital Cochin, AP-HP, Université Paris Descartes, Paris, France.
authors.forename: Pierre-Régis
authors.initials: PR
authors.lastname: Burgel
authors.forename: Anne
authors.initials: A
authors.lastname: Bergeron
authors.forename: Jacques
authors.initials: J
authors.lastname: de Blic
authors.forename: Philippe
authors.initials: P
authors.lastname: Bonniaud
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bourdin
authors.forename: Pascal
authors.initials: P
authors.lastname: Chanez
authors.forename: Thierry
authors.initials: T
authors.lastname: Chinet
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Dalphin
authors.forename: Philippe
authors.initials: P
authors.lastname: Devillier
authors.forename: Antoine
authors.initials: A
authors.lastname: Deschildre
authors.forename: Alain
authors.initials: A
authors.lastname: Didier
authors.forename: Marianne
authors.initials: M
authors.lastname: Kambouchner
authors.forename: Christiane
authors.initials: C
authors.lastname: Knoop
authors.forename: François
authors.initials: F
authors.lastname: Laurent
authors.forename: Hilario
authors.initials: H
authors.lastname: Nunes
authors.forename: Thierry
authors.initials: T
authors.lastname: Perez
authors.forename: Nicolas
authors.initials: N
authors.lastname: Roche
authors.forename: Isabelle
authors.initials: I
authors.lastname: Tillie-Leblond
authors.forename: Daniel
authors.initials: D
authors.lastname: Dusser
mesh_terms: D001706:Biopsy; D055745:Bronchioles / Q000473:pathology / Q000503:physiopathology; D001995:Bronchography / Q000379:methods; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D011237:Predictive Value of Tests; D011379:Prognosis; D012129:Respiratory Function Tests; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
keywords: Airway pathology; connective tissue disease; constrictive bronchiolitis; drug-induced lung disease; follicular bronchiolitis; immune deficiency