title: Balancing the fat: lipid droplets and human disease.
abstract: Lipid droplets (LDs) are dynamic, cytosolic lipid-storage organelles found in nearly all cell types. Too many or too few LDs during excess or deficient fat storage lead to many different human diseases. Recent insights into LD biology and LD protein functions shed new light on mechanisms underlying those metabolic pathologies. These findings will likely provide opportunities for treatment of diseases associated with too much or too little fat.
authors.affiliation: Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Krahmer
authors.forename: Robert V
authors.initials: RV
authors.lastname: Farese
authors.forename: Tobias C
authors.initials: TC
authors.lastname: Walther
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000150:complications / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000378:metabolism* / Q000473:pathology; D005234:Fatty Liver / Q000150:complications / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D024821:Metabolic Syndrome / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D009765:Obesity / Q000150:complications / Q000378:metabolism
keywords: atherosclerosis; lipid droplet; lipodystrophy; metabolic syndrome; triglyceride storage