title: Epigenetic therapy in lung cancer.
abstract: Epigenetic deregulation of gene function has been strongly implicated in carcinogenesis and is one of the mechanisms contributing to the development of lung cancer. The inherent reversibility of epigenetic alterations makes them viable therapeutic targets. Here, we review the therapeutic implications of epigenetic changes in lung cancer, and recent advances in therapeutic strategies targeting DNA methylation and histone acetylation.
authors.affiliation: Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California , Los Angeles, CA , USA.
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Liu
authors.forename: Muller
authors.initials: M
authors.lastname: Fabbri
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Gitlitz
authors.forename: Ite A
authors.initials: IA
authors.lastname: Laird-Offringa
keywords: DNA methylation; epigenetics; histone deacetylase inhibitors; hypomethylating agent; lung cancer; microRNAs