title: Efficacy of baroreflex activation therapy for the treatment of resistant hypertension.
abstract: The contribution of sympathetic activation in the development of hypertension is supported by early experimental evidence based on surgical denervation of sino-aortic baroreceptors or lesions of the central relay station of the baroreflex, the nucleus tractus solitarii. Disruption of this area of the brain was associated with an immediate increase in blood pressure. Sympathetic overactivity can also be triggered by impairment of the inhibitory function physiologically exerted by reflexogenic areas (arterial baroreceptors, cardiopulmonary receptors, and chemoreceptors) on adrenergic drive. Metabolic and humoral mechanisms are also thought to be involved in the development and progression of hypertension-related sympathetic overdrive.
authors.affiliation: ASH Comprehensive Hypertension Center, Department of Medicine, The University of Chicago Medicine, Chicago, IL 60637 , USA.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Briasoulis
authors.forename: George
authors.initials: G
authors.lastname: Bakris
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D017704:Baroreflex; D001794:Blood Pressure / Q000187:drug effects; D004351:Drug Resistance; D004599:Electric Stimulation Therapy; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D011311:Pressoreceptors / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents