title: Modification of the liver fatty acids by Hibiscus sabdariffa Linnaeus (Malvaceae) infusion, its possible effect on vascular reactivity in a metabolic syndrome model.
abstract: We investigated the effects of Hibiscus sabdariffa Linnaeus (HSL)-fed infusion on the fatty acid (FA) profile in liver of metabolic syndrome (MS) rats and its possible effect on vascular reactivity. Body mass, intra-abdominal fat, triglycerides, insulin, blood pressure, saturated, monounsaturated FA, NEFAs, Δ(9)-, Δ(6)-desaturases and vasoconstriction were increased, while vasorelaxation, polyunsaturated FA, endothelial nitric oxide and [Formula: see text]/[Formula: see text] ratio decreased in MS versus Control, but HSL infusion modified it and increased Δ(5)-desaturase. The results suggest that the alteration in FA liver metabolism in the MS contributes to impaired vascular reactivity, but treatment with of HSL infusion can improve this condition.
authors.affiliation: Departments of Pathology, Electromechanical Instrumentation, Cardiovascular Biomedicine and Physiology, Instituto Nacional de Cardiología Ignacio Chávez , Tlalpan, México, DF and.
authors.forename: Israel
authors.initials: I
authors.lastname: Pérez-Torres
authors.forename: Alejandra
authors.initials: A
authors.lastname: Zúñiga Muñoz
authors.forename: Ulises
authors.initials: U
authors.lastname: Beltrán-Rodríguez
authors.forename: Eulises
authors.initials: E
authors.lastname: Díaz-Díaz
authors.forename: Raúl
authors.initials: R
authors.lastname: Martínez-Memije
authors.forename: Verónica
authors.initials: V
authors.lastname: Guarner Lans
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000378:metabolism*; D031584:Hibiscus / Q000737:chemistry*; D007328:Insulin / Q000097:blood; D050152:Intra-Abdominal Fat / Q000378:metabolism; D008099:Liver / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000378:metabolism; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D051381:Rats; D014280:Triglycerides / Q000097:blood; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D005227:Fatty Acids; D007328:Insulin; D028321:Plant Preparations; D014280:Triglycerides