title: Does excess weight interfere with bone mass accumulation during adolescence?
abstract: Obesity and osteoporosis are important global health problems characterized by increasing prevalence with high impact on morbidity and mortality. The objective of this review was to determine whether excess weight during adolescence interferes with bone mass accumulation. If bone mineral gain can be optimized during puberty, adults are less likely to suffer from the devastating complications of osteoporosis. The increased fracture risk in obese children has also been attributed to a lower bone mass for weight compared to non-obese children. Thus, adiposity present in this age group may not result in the protection of bone mass, in contrast to what has been observed in adults. However, studies involving adolescents have reported both protective and detrimental effects of obesity on bone. The results and mechanisms of these interactions are controversial and have not been fully elucidated, a fact highlighting the extreme relevance of this topic and the need to monitor intervening and interactive variables.
authors.affiliation: Postgraduate Program in Gynecology, Obstetrics, and Mastology, Discipline of Adolescent Medicine, Department of Pediatrics, Botucatu School of Medicine, UNESP, São Paulo State University, Botucatu, SP 18618-970, Brazil. lunutricionista@yahoo.com.br
authors.forename: Luciana Nunes
authors.initials: LN
authors.lastname: Mosca
authors.forename: Valéria Nóbrega
authors.initials: VN
authors.lastname: da Silva
authors.forename: Tamara Beres Lederer
authors.initials: TB
authors.lastname: Goldberg
mesh_terms: D050154:Adiposity; D000293:Adolescent; D015992:Body Mass Index; D001835:Body Weight; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D016208:Databases, Factual; D050723:Fractures, Bone / Q000150:complications / Q000378:metabolism; D006801:Humans; D018977:Micronutrients / Q000008:administration & dosage / Q000097:blood; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D010024:Osteoporosis / Q000150:complications / Q000378:metabolism; D012307:Risk Factors
chemical_list: D018977:Micronutrients