title: Transthyretin-thyroid hormone internalization by trophoblasts.
abstract: Normal fetal neurological development depends on a regulated supply of maternal thyroid hormone (TH). We have previously demonstrated that transthyretin (TTR) a TH binding protein, is synthesized, secreted and internalized by trophoblast cells and may provide a route for the transfer of TH from mother to fetus. Our objective was to determine if a member of the low-density lipoprotein receptor family mediates TTR or TTR-TH internalization. TTR-TH internalization by JEG-3 cells is reduced in the presence of receptor associated protein (RAP) or albumin suggesting that TTR-TH is internalized through an LDL-receptor dependent endocytic process.
authors.affiliation: Conjoint Endocrine Laboratory, Clinical Research Centre, Royal Brisbane and Women's Hospital and Pathology Queensland, Herston, Queensland 4029, Australia. kerry.richard@qimr.edu.au
authors.forename: K A
authors.initials: KA
authors.lastname: Landers
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: V N
authors.initials: VN
authors.lastname: Subramaniam
authors.forename: R H
authors.initials: RH
authors.lastname: Mortimer
authors.forename: K
authors.initials: K
authors.lastname: Richard
mesh_terms: D045744:Cell Line, Tumor; D004705:Endocytosis; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange / Q000502:physiology; D011228:Prealbumin / Q000378:metabolism*; D011247:Pregnancy; D011973:Receptors, LDL / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism*; D013974:Thyroxine / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism*
chemical_list: D011228:Prealbumin; D011973:Receptors, LDL; D013963:Thyroid Hormones; D013974:Thyroxine