title: [Analgesic efficacy of topical lidocaine for vaso-occlusive crisis in children with sickle cell disease].
abstract: Pain associated with vaso-occlusive crisis is the main cause of hospitalization in children with sickle cell disease. Recent studies have suggested that pain might have a neuropathic component. Lidocaine patches are commonly prescribed as a topical analgesic in adult neuropathic pain. This study reports the efficacy and safety of such treatment in 6 patients with sickle cell disease, aged 6-18 years, who had been hospitalized for vaso-occlusive crisis after failure of the standard analgesic treatment. These data have led to setting up a confirmatory phase II trial, which is currently underway.
authors.affiliation: Institut d'hématologie et d'oncologie pédiatrique (IHOP), CHU de Lyon, 28, rue Laennec, 69373 Lyon cedex 08, France.
authors.forename: J
authors.initials: J
authors.lastname: Rasolofo
authors.forename: M
authors.initials: M
authors.lastname: Poncelet
authors.forename: V
authors.initials: V
authors.lastname: Rousseau
authors.forename: P
authors.initials: P
authors.lastname: Marec-Berard
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000755:Anemia, Sickle Cell / Q000188:drug therapy*; D000779:Anesthetics, Local / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D009020:Morphine / Q000627:therapeutic use; D010147:Pain Measurement
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D009020:Morphine; D008012:Lidocaine