title: Vesicular antioxidants: role in age-related cerebral oxidative injury.
abstract: Oxidative stress, due to the generation of reactive oxygen species, is a major factor in cerebral ischemic damage and changes the activities of antioxidant enzymes and substantially influences the aging process. Free chemical antioxidant is almost ineffective to treat brain ischemia as blood-brain barrier exists in between blood and brain interstitial fluid, limiting component to pass from the circulation into cerebral region. Different compounds have been tested in vivo in different vesiculated forms to prevent cerebral ischemia. Nanoparticle-encapsulated drug treatment resulted in a significant protection of the antioxidant enzymes in both young and old rats. Nanocapsulated drug treatment causes a substantial protection against cerebral ischemia-reperfusion-induced oxidative damage to all parts of brain specifically hippocampal regions of all age groups of rat brain.
authors.affiliation: Biomembrane Division, Indian Institute of Chemical Biology, Kolkata, West Bengal, India.
authors.forename: Sibani
authors.initials: S
authors.lastname: Sarkar
authors.forename: Ardhendu Kumar
authors.initials: AK
authors.lastname: Mandal
authors.forename: Nirmalendu
authors.initials: N
authors.lastname: Das
mesh_terms: D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001812:Blood-Brain Barrier; D001921:Brain / Q000098:blood supply / Q000201:enzymology / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism*; D002340:Carotid Artery Diseases / Q000188:drug therapy / Q000378:metabolism; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000008:administration & dosage*; D015227:Lipid Peroxidation; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D053758:Nanoparticles / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury
chemical_list: D000975:Antioxidants; D004337:Drug Carriers; D017382:Reactive Oxygen Species