title: Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults.
abstract: BACKGROUND
  We have previously demonstrated acute dose-dependent increases of flow-mediated dilatation (FMD) in the brachial artery after resveratrol consumption in mildly hypertensive, overweight/obese adults. Resveratrol supplementation has also been shown to increase cerebral blood flow acutely, without affecting cognition.
  
  
  OBJECTIVE
  To evaluate the effects of chronic resveratrol supplementation on both FMD and cognitive performance.
  
  
  METHODS
  Twenty-eight obese but otherwise healthy adults (BMI: 33.3 ± 0.6 kg/m) were randomized to take a single 75 mg capsule of trans-resveratrol (Resvida) or placebo daily for 6 weeks each in a double-blind crossover supplementation trial. Blood pressure, arterial compliance, FMD, and performance on the Stroop Color-Word Test were assessed at the end of each 6-week intervention period while fasted and at least 18 h after taking the last daily capsule. An additional capsule of the same supplement was then taken. FMD assessment was repeated 1 h later.
  
  
  RESULTS
  Chronic resveratrol supplementation for 6 weeks was well tolerated and resulted in a 23% increase in FMD compared with placebo (P=0.021, paired t-test). The extent of increase correlated negatively with baseline FMD (r=-0.47, P=0.01). A single dose of resveratrol (75 mg) following chronic resveratrol supplementation resulted in a 35% greater acute FMD response than the equivalent placebo supplementation. These FMD improvements remained significant after adjusting for baseline FMD. Blood pressure, arterial compliance, and all components of the Stroop Color-Word Test were unaffected by chronic resveratrol supplementation.
  
  
  CONCLUSIONS
  Daily resveratrol consumption was well tolerated and has the potential to maintain healthy circulatory function in obese adults.
authors.affiliation: aNutritional Physiology Research Centre, Sansom Institute for Health Research bSchool of Psychology, Social Work and Social Policy, University of South Australia, Adelaide, South Australia, Australia cR&D Human Nutrition and Health, DSM Nutritional Products Ltd, Kaiseraugst, Switzerland dClinical Nutrition Research Centre, University of Newcastle, Callaghan, New South Wales, Australia.
authors.forename: Rachel H X
authors.initials: RH
authors.lastname: Wong
authors.forename: Narelle M
authors.initials: NM
authors.lastname: Berry
authors.forename: Alison M
authors.initials: AM
authors.lastname: Coates
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Buckley
authors.forename: Janet
authors.initials: J
authors.lastname: Bryan
authors.forename: Iris
authors.initials: I
authors.lastname: Kunz
authors.forename: Peter R C
authors.initials: PR
authors.lastname: Howe
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D015992:Body Mass Index; D001916:Brachial Artery / Q000187:drug effects* / Q000473:pathology; D002339:Carotid Arteries / Q000473:pathology; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D050177:Overweight; D017698:Postmenopause; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D057190:Stroop Test; D011795:Surveys and Questionnaires; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D013267:Stilbenes; D000077185:Resveratrol