title: A genome-wide association study for reading and language abilities in two population cohorts.
abstract: Candidate genes have been identified for both reading and language, but most of the heritable variance in these traits remains unexplained. Here, we report a genome-wide association meta-analysis of two large cohorts: population samples of Australian twins and siblings aged 12-25 years (n = 1177 from 538 families), and a younger cohort of children of the UK Avon Longitudinal Study of Parents and their Children (aged 8 and 9 years; maximum n = 5472). Suggestive association was indicated for reading measures and non-word repetition (NWR), with the greatest support found for single nucleotide polymorphisms (SNPs) in the pseudogene, ABCC13 (P = 7.34 × 10(-8)), and the gene, DAZAP1 (P = 1.32 × 10(-6)). Gene-based analyses showed significant association (P < 2.8 × 10(-6)) for reading and spelling with genes CD2L1, CDC2L2 and RCAN3 in two loci on chromosome 1. Some support was found for the same SNPs having effects on both reading skill and NWR, which is compatible with behavior genetic evidence for influences of reading acquisition on phonological-task performance. The results implicate novel candidates for study in additional cohorts for reading and language abilities.
authors.affiliation: Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK. michelle.luciano@ed.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Luciano
authors.forename: D M
authors.initials: DM
authors.lastname: Evans
authors.forename: N K
authors.initials: NK
authors.lastname: Hansell
authors.forename: S E
authors.initials: SE
authors.lastname: Medland
authors.forename: G W
authors.initials: GW
authors.lastname: Montgomery
authors.forename: N G
authors.initials: NG
authors.lastname: Martin
authors.forename: M J
authors.initials: MJ
authors.lastname: Wright
authors.forename: T C
authors.initials: TC
authors.lastname: Bates
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D018844:Cyclin-Dependent Kinases / Q000235:genetics; D004410:Dyslexia / Q000235:genetics; D005260:Female; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D006801:Humans; D007804:Language Development; D007807:Language Tests; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011153:Population / Q000235:genetics*; D011544:Pseudogenes; D016601:RNA-Binding Proteins / Q000235:genetics; D011932:Reading; D035781:Siblings; D014427:Twins
chemical_list: C470491:ABCC13 pseudogene, human; D018528:ATP-Binding Cassette Transporters; D048868:Adaptor Proteins, Signal Transducing; C412481:DAZAP1 protein, human; C408372:RCAN3 protein, human; D016601:RNA-Binding Proteins; C447612:CDK11a protein, human; D018844:Cyclin-Dependent Kinases
keywords: Association; GWAS; dyslexia; genes; language; reading