title: Effect of repeated oral administration of bifenthrin on lipid peroxidation and anti-oxidant parameters in Wistar rats.
abstract: The oxidative stress-inducing potential of the pyrethroid insecticide, bifenthrin, was evaluated in rats at 5.8 mg/kg body weight once daily for 20 or 30 days. Bifenthrin treated animals showed significantly increased lipid peroxidation, evidenced by increased blood malondialdehyde levels. Blood glutathione levels and activities of catalase and glutathione peroxidase decreased significantly in the bifenthrin treated animals after both 20 and 30 days of treatment, whereas, the activities of superoxide dismutase and glutathione S-transferase decreased significantly only on the 30th day. In conclusion, bifenthrin has a potential to induce severe oxidative stress in rats exposed to sublethal concentrations.
authors.affiliation: Department of Veterinary Pharmacology and Toxicology, Shere-Kashmir University of Agricultural Sciences and Technology, Jammu, India.
authors.forename: Muneer Ahmad
authors.initials: MA
authors.lastname: Dar
authors.forename: Adil Mehraj
authors.initials: AM
authors.lastname: Khan
authors.forename: Rajinder
authors.initials: R
authors.lastname: Raina
authors.forename: Pawan Kumar
authors.initials: PK
authors.lastname: Verma
authors.forename: Mudasir
authors.initials: M
authors.lastname: Sultana
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001774:Blood Chemical Analysis; D004785:Environmental Pollutants / Q000494:pharmacology*; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011722:Pyrethrins / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D059551:Toxicity Tests, Subacute
chemical_list: D000975:Antioxidants; D004785:Environmental Pollutants; D007306:Insecticides; D011722:Pyrethrins; C099952:bifenthrin