title: Deep C diving: mapping the low-abundance modifications of the DNA demethylation pathway.
abstract: Two new studies imply that the reprogramming of 5-methylcytosine via TET- and TDG-family enzymes is both widespread throughout the genome and functionally significant.
authors.forename: John P
authors.initials: JP
authors.lastname: Thomson
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Hunter
authors.forename: Richard R
authors.initials: RR
authors.lastname: Meehan
mesh_terms: D044503:5-Methylcytosine / Q000378:metabolism*; D000818:Animals; D003596:Cytosine / Q000031:analogs & derivatives*; D053595:Embryonic Stem Cells / Q000378:metabolism*; D044127:Epigenesis, Genetic; D005821:Genetic Techniques; D055106:Genome-Wide Association Study
chemical_list: D044503:5-Methylcytosine; D003596:Cytosine