title: Influence of ovarian endometrioma on expression of steroid receptor RNA activator, estrogen receptors, vascular endothelial growth factor, and thrombospondin 1 in the surrounding ovarian tissues.
abstract: This study investigates the influence of ovarian endometrioma on expression of steroid receptor RNA activator (SRA), estrogen receptors (ERs), vascular endothelial growth factor (VEGF), and thrombospondin 1 (TSP-1) in the surrounding ovarian tissues. Taken from the women with ovarian endometrioma and mature teratoma during laparoscopy, the biopsies were analyzed by real-time polymerase chain reaction and Western blot. Our results indicated that ovarian tissues surrounding endometrioma had lower SRA and ER-α levels but higher SRA protein (SRAP) and ER-β levels than ovarian endometrioma. With lower VEGF levels and higher TSP-1 levels, the surrounding ovarian tissues showed higher expression levels of SRA, SRAP, ER-α, and ER-β in the ovarian endometrioma group when compared to the controls. These data showed that ovarian endometrioma increases SRA, ERs, and TSP-1 but decreases VEGF levels in the surrounding ovarian tissues, suggesting that abnormal expression of these molecules may affect biological behaviors of ovarian endometrioma.
authors.affiliation: 1Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, People's Republic of China.
authors.forename: Kaiqing
authors.initials: K
authors.lastname: Lin
authors.forename: Junyan
authors.initials: J
authors.lastname: Ma
authors.forename: Ruijin
authors.initials: R
authors.lastname: Wu
authors.forename: Caiyun
authors.initials: C
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D000328:Adult; D002352:Carrier Proteins / Q000096:biosynthesis*; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D047628:Estrogen Receptor alpha / Q000096:biosynthesis; D047629:Estrogen Receptor beta / Q000096:biosynthesis; D005260:Female; D006801:Humans; D010053:Ovary / Q000378:metabolism* / Q000473:pathology; D011960:Receptors, Estrogen / Q000096:biosynthesis*; D019700:Thrombospondin 1 / Q000096:biosynthesis*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*; D055815:Young Adult
chemical_list: D002352:Carrier Proteins; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D011960:Receptors, Estrogen; D019700:Thrombospondin 1; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C548898:steroid receptor RNA activator, human
keywords: estrogen receptor; ovarian endometrioma; steroid receptor RNA activator; thrombospondin 1; vascular endothelial growth factor