title: Super-radical surgery for anaplastic thyroid carcinoma: a large cohort study using the Anaplastic Thyroid Carcinoma Research Consortium of Japan database.
abstract: BACKGROUND
  The consequences of super-radical resection in patients with anaplastic thyroid carcinoma (ATC) have not been fully investigated.
  
  
  METHODS
  This retrospective study used the multicenter ATC Research Consortium of Japan database. Among 233 stage IVB patients, 23 underwent super-radical resection (group S). Outcomes for group S were compared to those for patients with restricted curative surgery (group R; n = 49), palliative surgery (group P; n = 72) or no surgery (group N; n = 80).
  
  
  RESULTS
  One-year cause-specific survival rate for group S was 33%. It was identical to group R (p = .94) and significantly better than groups N and P (p = .0065). Permanent tracheostomy was significantly more frequent in group S than in other groups, but only 5 patients died directly from local disease.
  
  
  CONCLUSIONS
  Radical resection offers significantly better outcomes than limited surgery. Super-radical procedures may be indicated in select patients to avoid mortality due to locally uncontrolled disease at the expense of tracheostomy.
authors.affiliation: Division of Head and Neck, Cancer Institute Hospital, Tokyo, Japan.
authors.forename: Iwao
authors.initials: I
authors.lastname: Sugitani
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Masashi
authors.initials: M
authors.lastname: Sugasawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tori
authors.forename: Takuya
authors.initials: T
authors.lastname: Higashiyama
authors.forename: Masakazu
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hosoi
authors.forename: Yorihisa
authors.initials: Y
authors.lastname: Orita
authors.forename: Hiroya
authors.initials: H
authors.lastname: Kitano
mesh_terms: D000368:Aged; D016208:Databases, Factual; D016629:Esophagectomy; D005260:Female; D006801:Humans; D007564:Japan; D007825:Laryngectomy; D008297:Male; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D010611:Pharyngectomy; D011379:Prognosis; D011788:Quality of Life; D012189:Retrospective Studies; D065646:Thyroid Carcinoma, Anaplastic; D013964:Thyroid Neoplasms / Q000601:surgery*; D014140:Tracheotomy; D016896:Treatment Outcome
keywords: anaplastic thyroid carcinoma; multicenter registry; prognostic factor; quality of life; super-radical surgery