title: Haemodynamic alterations in cerebral blood vessels after carotid artery revascularisation: quantitative analysis using 2D phase-contrast MRI.
abstract: OBJECTIVE
  This study was conducted to evaluate the effect of revascularisation, whether revascularisation improves total cerebral blood flow volume (FVTCBF), and how cerebral veins would respond to altered FVTCBF.
  
  
  METHODS
  The 39 carotid artery stenoses in 37 patients who underwent revascularisation including 32 stentings and 7 endarterectomies were included in this prospective study. From the two-dimensional phase-contrast (2D-PC) MRI acquired before and after revascularisation, the flow volumes (FVs) of the arteries and veins were compared using paired t-test. The relationships between these parameters were correlated using Pearson's correlation coefficient.
  
  
  RESULTS
  The mean FV in the treated carotid artery (proportion of treated artery among total FV) increased from 162.06 ml/min (25.80 %) to 267.71 ml/min (37.21 %; P < 0.001). Revascularisation increased the FVTCBF of patients from 638.66 ml/min to 716.72 ml/min (P < 0.001). The FV of the internal jugular veins, superior sagittal and straight sinuses (FVSS + SSS), and transverse sinuses increased after revascularisation (P < 0.05). Positive relationships were shown between the FVTCBF and the FVSS + SSS (r = 0.584-0.741, P < 0.001).
  
  
  CONCLUSIONS
  Revascularisation improves the FVTCBF by increasing the FV in the treated carotid artery. The venous drainages are closely linked to FVTCBF. 2D-PC-MRI is a feasible method for evaluating comprehensively the haemodynamic improvement after revascularisation.
  
  
  CONCLUSIONS
  • Revascularisation may be beneficial in ischaemic strokes due to carotid artery stenosis. • Revascularisation of the affected artery increases total cerebral blood flow volume ( FV TCBF). • Cerebral venous drainage, closely linked to FV TCBF, is also improved. • Two-dimensional phase-contrast MRI can comprehensively assess these haemodynamic improvements after carotid revascularisation.
authors.affiliation: Department of Radiology, Catholic University of Daegu School of Medicine, 3056-6 Daemyung-4 Dong, Nam-Gu, Daegu, 705-718, Korea, ysw10adest@cu.ac.kr.
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Youn
authors.forename: Ho Kyun
authors.initials: HK
authors.lastname: Kim
authors.forename: Young Rok
authors.initials: YR
authors.lastname: Do
authors.forename: Jin Kook
authors.initials: JK
authors.lastname: Do
authors.forename: Oh Choon
authors.initials: OC
authors.lastname: Kwon
authors.forename: Nahee
authors.initials: N
authors.lastname: Lee
authors.forename: Hui Joong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jongmin
authors.initials: J
authors.lastname: Lee
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D001810:Blood Volume; D016893:Carotid Stenosis / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D002536:Cerebral Arteries / Q000473:pathology / Q000503:physiopathology*; D002548:Cerebral Revascularization / Q000379:methods*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome