title: Nephroprotective activity of Cocculus hirsutus leaf extract in 5/6 nephrectomized rat model.
abstract: BACKGROUND
  Cocculus hirsutus, commonly known as broom creeper, belongs to the family Menispermaceae. It is widely used in folk medicine to treat leprosy, skin diseases, dyspepsia, etc. Hence, an effort has been made to investigate the nephroprotective potential of C. hirsutus.
  
  
  METHODS
  The nephroprotective activity of ethanolic C. hirsutus leaf extract (ECHE) in the 5/6 nephrectomized rat model was investigated. Different parameters like postoperative survival rate, change in body weight and levels of red blood corpuscles (RBCs), hemoglobin (Hb), triglyceride, cholesterol, creatinine, urea and uric acid were estimated in experimental rats.
  
  
  RESULTS
  The findings revealed the postoperative survival rate of rats in the investigated novel method to be 100%. Change in the body weight of ECHE-treated groups I and II was found to be 32 and 30 g, respectively. These values suggested that ECHE treatment normalized the elevated body weight levels in experimental rats. Furthermore, ECHE treatment normalized the decreased RBC levels and the elevated Hb, triglyceride, cholesterol, creatinine, urea and uric acid levels in experimental rats.
  
  
  CONCLUSIONS
  The results indicate that C. hirsutus has strong nephroprotective activity. However, further scrutiny is essential for isolation and characterization of the active components that can be employed to allay various human maladies.
authors.forename: Tharun Kumar
authors.initials: TK
authors.lastname: Gadapuram
authors.forename: Josyula Surya Narayana
authors.initials: JS
authors.lastname: Murthy
authors.forename: Raja Reddy
authors.initials: RR
authors.lastname: Rajannagari
authors.forename: Vasu
authors.initials: V
authors.lastname: Kandati
authors.forename: Pradeep Kumar
authors.initials: PK
authors.lastname: Choda
authors.forename: Rahul
authors.initials: R
authors.lastname: Shukla
mesh_terms: D000818:Animals; D031605:Cocculus / Q000737:chemistry*; D004195:Disease Models, Animal; D000431:Ethanol / Q000737:chemistry; D007677:Kidney Function Tests; D008297:Male; D008515:Medicine, Ayurvedic; D009392:Nephrectomy; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D020011:Protective Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000188:drug therapy* / Q000473:pathology
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D000431:Ethanol