title: Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis.
abstract: Gram-negative bacteria decorate their outermost surface structure, lipopolysaccharide, with elaborate chemical moieties, which effectively disguises them from immune surveillance and protects them from the onslaught of host defences. Many of these changes occur on the lipid A moiety of lipopolysaccharide, a component that is crucial for host recognition of Gram-negative infection. In this Review, we describe the regulatory mechanisms controlling lipid A modification and discuss the impact of modifications on pathogenesis, bacterial physiology and bacterial interactions with the host immune system.
authors.affiliation: The Institute of Cellular and Molecular Biology, The University of Texas at Austin, 78712, USA.
authors.forename: Brittany D
authors.initials: BD
authors.lastname: Needham
authors.forename: M Stephen
authors.initials: MS
authors.lastname: Trent
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D006090:Gram-Negative Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008050:Lipid A / Q000378:metabolism*; D015398:Signal Transduction; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D008050:Lipid A