title: Primary sarcomas of the salivary glands: case series and literature review.
abstract: BACKGROUND
  Mesenchymal malignancies of salivary origin are rare and are histologically diverse. We reviewed our experience with these tumors, as well as the published literature, with an emphasis on treatment modalities and prognosis.
  
  
  METHODS
  We identified 17 patients treated for malignant mesenchymal cell tumors at The University of Texas MD Anderson Cancer Center between 1990 and 2007. We compared our results to the literature from January 1990 to July 2010.
  
  
  RESULTS
  Tumors were located primarily in the parotid gland and were primarily T1 tumors (<5 cm). All patients were treated with surgical resection, and 13 patients were given adjuvant therapy. Seven patients (41%) had recurrence, and 4 developed distant metastases. The overall 5-year and 10-year survival rates were 42% and 20%, respectively.
  
  
  CONCLUSIONS
  Our case series and literature review show that sarcomas of the salivary glands have a high rate of recurrence and are associated with a poor prognosis.
authors.affiliation: The University of Texas Medical School at Houston, Houston, Texas.
authors.forename: Cara C
authors.initials: CC
authors.lastname: Cockerill
authors.forename: Shiva
authors.initials: S
authors.lastname: Daram
authors.forename: Adel K
authors.initials: AK
authors.lastname: El-Naggar
authors.forename: Ehab Y
authors.initials: EY
authors.lastname: Hanna
authors.forename: Randal S
authors.initials: RS
authors.lastname: Weber
authors.forename: Michael E
authors.initials: ME
authors.lastname: Kupferman
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D002173:Cancer Care Facilities; D003131:Combined Modality Therapy; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology; D009367:Neoplasm Staging; D010307:Parotid Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D035583:Rare Diseases; D012468:Salivary Gland Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D012469:Salivary Glands / Q000601:surgery; D012494:Sampling Studies; D012509:Sarcoma / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D016019:Survival Analysis; D055815:Young Adult
keywords: mesenchymal; parotid; salivary gland; sarcoma; surgery