title: Alcohol use disorders and hospital-acquired infections in women undergoing cesarean delivery.
abstract: OBJECTIVE
  To determine the risk of hospital-acquired infection in women with alcohol use disorders undergoing cesarean delivery.
  
  
  METHODS
  Using the Nationwide Inpatient Sample, we conducted a retrospective cohort study of women undergoing cesarean delivery from 2002 to 2010. Women with a diagnosis of alcohol use disorder were compared with women without alcohol use disorders. Hospital-acquired infections include surgical site infection, endometritis, urinary tract infection, sepsis, and pneumonia.
  
  
  RESULTS
  A total of 12,081 women with alcohol use disorders were identified and matched with 11,960 women without alcohol use disorders. Women with alcohol use disorders were more likely to have development of urinary tract infection and sepsis. By multivariable analyses, women with alcohol use disorders had higher odds of hospital-acquired infections (odds ratio 2.2, 95% confidence interval [CI] 1.9-2.7; P=2×10; 397 among those with alcohol use disorders and 179 among those without alcohol use disorders; number needed to harm 55). Length of stay was longer in women with alcohol use disorders, but this was unexplained by hospital-acquired infection (3.3 days; 95% CI 3.2-3.3 compared with 3.1 days; 95% CI 3.0-3.1; P=4×10).
  
  
  CONCLUSIONS
  Women with alcohol use disorders undergoing cesarean delivery have increased risk of hospital-acquired infections. Interventions aimed at decreasing alcohol use disorders during pregnancy may reduce maternal and fetal complications.
  
  
  METHODS
  II.
authors.affiliation: Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, and the Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia.
authors.forename: Marjolein
authors.initials: M
authors.lastname: de Wit
authors.forename: Aaron
authors.initials: A
authors.lastname: Goldberg
authors.forename: David
authors.initials: D
authors.lastname: Chelmow
mesh_terms: D000328:Adult; D019973:Alcohol-Related Disorders / Q000453:epidemiology*; D002585:Cesarean Section / Q000009:adverse effects*; D015331:Cohort Studies; D003428:Cross Infection / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data*; D011247:Pregnancy; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D014481:United States