title: The RIG-I/MAVS signaling pathway in cancer cell-selective apoptosis.
abstract: A replication-incompetent hemagglutinating virus of Japan (HVJ) envelope (HVJ-E) induces apoptosis selectively in cancer cells. Fragments of the viral RNA genome transported by HVJ-E are recognized by retinoic acid-inducible gene I (RIG-I) and mitochondrial antiviral signaling (MAVS). Specific pro-apoptotic factor are selectively upregulated in cancer cells downstream of the RIG-I/MAVS pathway.
authors.affiliation: Division of Gene Therapy Science; Department of Urology; Department of Pediatric Surgery; Graduate School of Medicine; Osaka University; Yamada-oka, Japan.
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Kaneda
keywords: HVJ; MAVS; RIG-I; apoptosis; cancer; oncolytic virus; viral RNA