title: The role of viscosity and fermentability of dietary fibers on satiety- and adiposity-related hormones in rats.
abstract: Dietary fiber may contribute to satiety. This study examined the effect of two dietary fiber characteristics, small intestinal contents viscosity and large intestinal fermentability, on satiety-and adiposity-related hormones in rats. Diets contained fiber sources that were non-viscous, somewhat viscous, or highly viscous, and either highly fermentable or non-fermentable, in a 2 × 3 factorial design. In the fed state (2 h postprandial), rats fed non-fermentable fibers had significantly greater plasma GLP-1 concentration than fermentable fibers. In the fasted state, among non-fermentable fibers, viscosity had no effect on GLP-1 concentration. However, among fermentable fibers, greater viscosity reduced GLP-1 concentration. Plasma peptide tyrosine tyrosine (PYY) concentrations in the fasted state were not influenced by the fermentability of the fiber overall, however animals consuming a fructooligosaccharide greater PYY concentration. In both the fed and fasted states, rats fed non-fermentable fibers had a significantly lower plasma ghrelin concentration than rats fed fermentable fibers. In the fasted state, rats fed non-fermentable fibers had a significantly lower plasma leptin concentration than rats fed fermentable fibers. Thus, fermentability and viscosity of dietary fiber interacted in complex ways to influence satiety- and adiposity-related plasma hormone concentrations. However, the results suggest that highly viscous, non-fermentable fibers may limit weight gain and reduce adiposity and non-fermentable fibers, regardless of viscosity, may promote meal termination.
authors.affiliation: Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA. schr0620@umn.edu
authors.forename: Natalia
authors.initials: N
authors.lastname: Schroeder
authors.forename: Len F
authors.initials: LF
authors.lastname: Marquart
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Gallaher
mesh_terms: D050154:Adiposity; D000818:Animals; D001835:Body Weight; D004032:Diet; D004043:Dietary Fiber / Q000008:administration & dosage* / Q000378:metabolism*; D005285:Fermentation; D054439:Ghrelin / Q000097:blood; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D009929:Organ Size; D019894:Peptide YY / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012527:Satiation; D014783:Viscosity
chemical_list: D004043:Dietary Fiber; D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D019894:Peptide YY; D052216:Glucagon-Like Peptide 1