title: Treatment options for high-grade squamous intraepithelial lesions.
abstract: The introduction of testing for high-risk HPV types and P16 immunostaining of CIN2 histologic specimens allows for determination of the risk of progression versus regression for a woman with a particular cytologic or histologic specimen. Observation with serial cytological or colposcopic examinations is now appropriate for women with low-grade histologic lesions as well as pregnant and young women with certain high-grade histologic lesions. Current recommendations for management of high-grade lesions, the efficacy of treatment options (cryotherapy and LEEP), and the immediate (bleeding, infection) and longer term complications (cervical incompetence, preterm delivery) of cervical dysplasia treatment are presented.
authors.affiliation: Department of Family & Community Medicine, University of New Mexico, 1 University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Long
authors.forename: Lawrence
authors.initials: L
authors.lastname: Leeman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003127:Colposcopy / Q000009:adverse effects; D019092:Conization / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D017679:Cryotherapy / Q000009:adverse effects; D004598:Electrosurgery / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D005260:Female; D005838:Genotype; D006679:HIV Seropositivity; D006801:Humans; D008403:Mass Screening / Q000379:methods / Q000639:trends; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D007752:Obstetric Labor, Premature / Q000209:etiology; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology; D053918:Papillomavirus Vaccines; D011247:Pregnancy; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000628:therapy* / Q000821:virology; D014626:Vaginal Smears; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000628:therapy* / Q000821:virology
chemical_list: D053918:Papillomavirus Vaccines