title: A pediatric case of New Delhi metallo-β-lactamase-1-producing Enterobacteriaceae in the United States.
abstract: We report the second pediatric case of New Delhi metallo-β-lactamase-1-producing Enterobacteriaceae in the United States. Laboratory methods included various phenotypic antimicrobial susceptibility testing assays, as well as polymerase chain reaction assays for carbapenemase-encoding genes. Laboratory challenges and the limited number of effective antimicrobial agents and the lack of pediatric-specific safety and efficacy data for these drugs are discussed.
authors.affiliation: From the *Department of Pathology, Stanford University School of Medicine, Stanford; †Clinical Microbiology Laboratory, Stanford University Medical Center, Palo Alto; ‡Department of Pediatrics, Stanford University School of Medicine, Stanford; §Cepheid, Sunnyvale; and ¶Department of Medicine, Stanford University School of Medicine, Stanford, CA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Green
authors.forename: Nivedita
authors.initials: N
authors.lastname: Srinivas
authors.forename: Nancy
authors.initials: N
authors.lastname: Watz
authors.forename: Fred C
authors.initials: FC
authors.lastname: Tenover
authors.forename: Manuel
authors.initials: M
authors.lastname: Amieva
authors.forename: Niaz
authors.initials: N
authors.lastname: Banaei
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D004755:Enterobacteriaceae / Q000145:classification / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D005578:Fosfomycin / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D000078304:Tigecycline; D014481:United States; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D000078304:Tigecycline; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1; D008911:Minocycline