title: Consensus on diagnosis and management of JME: From founder's observations to current trends.
abstract: An international workshop on juvenile myoclonic epilepsy (JME) was conducted in Avignon, France in May 2011. During that workshop, a group of 45 experts on JME, together with one of the founding fathers of the syndrome of JME ("Janz syndrome"), Prof. Dr. Dieter Janz from Berlin, reached a consensus on diagnostic criteria and management of JME. The international experts on JME proposed two sets of criteria, which will be helpful for both clinical and scientific purposes. Class I criteria encompass myoclonic jerks without loss of consciousness exclusively occurring on or after awakening and associated with typical generalized epileptiform EEG abnormalities, with an age of onset between 10 and 25. Class II criteria allow the inclusion of myoclonic jerks predominantly occurring after awakening, generalized epileptiform EEG abnormalities with or without concomitant myoclonic jerks, and a greater time window for age at onset (6-25years). For both sets of criteria, patients should have a clear history of myoclonic jerks predominantly occurring after awakening and an EEG with generalized epileptiform discharges supporting a diagnosis of idiopathic generalized epilepsy. Patients with JME require special management because their epilepsy starts in the vulnerable period of adolescence and, accordingly, they have lifestyle issues that typically increase the likelihood of seizures (sleep deprivation, exposure to stroboscopic flashes in discos, alcohol intake, etc.) with poor adherence to antiepileptic drugs (AEDs). Results of an inventory of the different clinical management strategies are given. This article is part of a supplemental special issue entitled Juvenile Myoclonic Epilepsy: What is it Really?
authors.affiliation: University of Rome Sapienza II, Rome, Italy. dkasteleijn@planet.nl
authors.forename: Dorothée G A
authors.initials: DG
authors.lastname: Kasteleijn-Nolst Trenité
authors.forename: Bettina
authors.initials: B
authors.lastname: Schmitz
authors.forename: Dieter
authors.initials: D
authors.lastname: Janz
authors.forename: Antonio V
authors.initials: AV
authors.lastname: Delgado-Escueta
authors.forename: Pierre
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authors.lastname: Thomas
authors.forename: Edouard
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authors.lastname: Hirsch
authors.forename: Holger
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authors.lastname: Lerche
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authors.lastname: Martínez-Juárez
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authors.lastname: Duron
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authors.lastname: Koutroumanidis
authors.forename: Ulrich
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authors.lastname: Stephani
authors.forename: Javier
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authors.lastname: Salas-Puig
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Reed
authors.forename: Friedrich
authors.initials: F
authors.lastname: Woermann
authors.forename: Britta
authors.initials: B
authors.lastname: Wandschneider
authors.forename: Michelle
authors.initials: M
authors.lastname: Bureau
authors.forename: Antonio
authors.initials: A
authors.lastname: Gambardella
authors.forename: Matthias J
authors.initials: MJ
authors.lastname: Koepp
authors.forename: Philippe
authors.initials: P
authors.lastname: Gelisse
authors.forename: Cardan
authors.initials: C
authors.lastname: Gurses
authors.forename: Arielle
authors.initials: A
authors.lastname: Crespel
authors.forename: Vi Huong
authors.initials: VH
authors.lastname: Nguyen-Michel
authors.forename: Edoardo
authors.initials: E
authors.lastname: Ferlazzo
authors.forename: Thierry
authors.initials: T
authors.lastname: Grisar
authors.forename: Ingo
authors.initials: I
authors.lastname: Helbig
authors.forename: Bobby P C
authors.initials: BP
authors.lastname: Koeleman
authors.forename: Pasquale
authors.initials: P
authors.lastname: Striano
authors.forename: Michael
authors.initials: M
authors.lastname: Trimble
authors.forename: Russel
authors.initials: R
authors.lastname: Buono
authors.forename: Patrick
authors.initials: P
authors.lastname: Cossette
authors.forename: Alfonso
authors.initials: A
authors.lastname: Represa
authors.forename: Charlotte
authors.initials: C
authors.lastname: Dravet
authors.forename: Anna
authors.initials: A
authors.lastname: Serafini
authors.forename: Ivanka Savic-
authors.initials: IS
authors.lastname: Berglund
authors.forename: Sanjay M
authors.initials: SM
authors.lastname: Sisodiya
authors.forename: Kazuhiro
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authors.lastname: Yamakawa
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authors.lastname: Genton
mesh_terms: D019468:Disease Management; D006801:Humans; D007391:International Cooperation; D020190:Myoclonic Epilepsy, Juvenile / Q000175:diagnosis* / Q000628:therapy*