title: [Amplitude-integrated electroencephalographic changes in neonates with acute bilirubin encephalopathy].
abstract: OBJECTIVE
  To characterize amplitude-integrated electroencephalo graphic (aEEG) traces in neonates with acute bilirubin encephalopathy (ABE), explore the value of aEEG in early diagnosis and prediction of neurological outcome of ABE.
  
  
  METHODS
  aEEG records of 10 cases with ABE (Oct 2009-Nov 2011) were reviewed to identify neonates with a diagnosis of ABE. Clinical data were collected. The aEEG traces were classified according to background activity (normal, moderate, or severely abnormal), presence of seizures and sleep-wake cycling (SWC). Brainstem auditory evoked potential (BAEP) and magnetic resonance imaging (MRI) were studied. The neuromotor development of survivors with ABE was assessed by using the Infant Neurological International Battery (INFANIB).
  
  
  RESULTS
  The characteristics of aEEG tracings in these infants with ABE were shown continuous normal voltage (CNV, n = 5), discontinuous voltage (DNV, n = 4), discontinuous voltage with burst-suppression (BS)BS+ (n = 1); mature SWC (n = 2), immature SWC (n = 5), no SWC (n = 3); 8 infants (80%) had electrical seizures: single seizure (n = 2); repetitive seizures (n = 2), and status epilepticus (SE) (n = 4). Among the 10 infants with ABE, no infants had normal aEEG, 3 had mildly abnormal aEEG, and 7 had severely abnormal aEEG. Eight infants accepted BAEP test, 2 were mildly abnormal and 6 were severely abnormal. Six infants accepted MRI, 1 was normal and 5 were abnormal. By chi-square analysis and Spearman rank correlation analysis, the results of aEEG classification were correlated with the phase of ABE and the severity of BAEP. These infants were followed up for more than 6 months (range 6 months to 1 year). In 3 infants with mildly abnormal aEEG, 2 were normal and 1 was transit in infanib score at 6 months of age. Of 7 infants with severely abnormal aEEG, 1 died, 3 were abnormal (2 Spastic dyskinesia and 1 hypotonia), 2 were transit in infanib score at 6 months old. 1 lost to follow-up.
  
  
  CONCLUSIONS
  Amplitude-integrated electroencephalography can provide important information of the status of cerebral function in neonates with ABE and help to predict its neurological outcome.
authors.affiliation: Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Luo
authors.forename: Hui-jia
authors.initials: HJ
authors.lastname: Lin
authors.forename: Yu
authors.initials: Y
authors.lastname: Bao
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chen
authors.forename: Xiao-lu
authors.initials: XL
authors.lastname: Ma
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Shi
authors.forename: Li-zhong
authors.initials: LZ
authors.lastname: Du
mesh_terms: D001921:Brain / Q000502:physiology*; D042241:Early Diagnosis; D004569:Electroencephalography; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000150:complications; D007231:Infant, Newborn; D007234:Infant, Premature; D007647:Kernicterus / Q000175:diagnosis* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests; D012640:Seizures / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D012720:Severity of Illness Index; D012890:Sleep / Q000502:physiology