title: Correlation between plasma lipoprotein-associated phospholipase A2and peripheral arterial disease.
abstract: Lipoprotein-associated phospholipase A2(Lp-PLA2) is a recently identified and potentially useful plasma biomarker for cardiovascular diseases. However, its role in peripheral arterial disease (PAD) remains unclear. The objective of this study was to assess the independent association of Lp-PLA2and other inflammatory markers with the reduced ankle-brachial blood pressure index (ABI), a marker of PAD. We performed a cross-sectional study in 982 individuals aged ≥40 years who were recruited from the First Affiliated Hospital of Zhengzhou University. PAD was defined as an ABI <0.9 in at least one leg. The individuals were further divided into two groups, 145 with PAD and 837 without PAD. Following adjustment for traditional cardiovascular risk factors, the odds ratios of PAD when comparing the highest to the lowest quartiles were 3.24 (95% CI, 1.68-3.94) for Lp-PLA2, 2.14 (95% CI, 1.07-3.11) for homocysteine, 1.93 (95% CI, 1.02-4.01) for fibrinogen, 2.26 (95% CI, 1.32-5.74) for apolipoprotein B and 1.3 (95% CI, 0.75-2.49) for high-sensitivity C-reactive protein (hsCRP). When Lp-PLA2and inflammatory markers were simultaneously included in the full model, the corresponding odds ratios were 1.81 (95% CI, 1.14-3.68) for Lp-PLA2, 1.15 (95% CI, 0.49-2.69) for homocysteine, 1.21 (95% CI, 0.88-5.57) for fibrinogen, 0.98 (95% CI, 0.51-3.85) for apolipoprotein B and 1.23 (95% CI, 1.12-3.51) for hsCRP. Lp-PLA2levels were significantly and independently associated with PAD following adjustment for other inflammatory markers. These findings reflect the potential role of circulating Lp-PLA2as a marker of atherosclerosis.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Henan 450052, P.R. China.
authors.forename: Shuai-Bing
authors.initials: SB
authors.lastname: Li
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Jing
authors.forename: Juan
authors.initials: J
authors.lastname: Ma
authors.forename: Ya-Dan
authors.initials: YD
authors.lastname: Jia
authors.forename: Shao-Ying
authors.initials: SY
authors.lastname: Dong
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Zheng
authors.forename: Luo-Sha
authors.initials: LS
authors.lastname: Zhao
keywords: atherosclerosis; biomarker; lipoprotein-associated phospholipase A2; peripheral arterial disease; risk factors