title: Effect of the colloids gelatin and HES 130/0.4 on blood coagulation in cardiac surgery patients: a randomized controlled trial.
abstract: OBJECTIVE
  The choice of the prime solution for cardiopulmonary bypass can play an important role in limiting the effect on blood coagulation, but it is still unclear what the effect of colloids on blood coagulation is. The aim of this study was to investigate the effect of synthetic colloids on blood loss and blood coagulation in patients after on-pump coronary artery bypass graft (CABG) procedures.
  
  
  METHODS
  Sixty elective, on-pump CABG patients were randomly assigned to receive the prime solutions lactated Ringer's solution combined with hydroxyethyl starch 130/0.4 (HES, 6% Volulyte, Fresenius Kabi Nederland BV, Zeist, the Netherlands) (HES group) or gelatin (Gelofusin(®), B Braun Melsung AG, Melsungen, Germany) (Gelo group). Blood loss was assessed using post-operative chest tube output; secondary endpoints were number of blood component transfusions, routine coagulation test values and rotation thromboelastometry values (Rotem(®) delta, Pentapharm GmbH, Munich, Germany).
  
  
  RESULTS
  Total post-operative chest tube output was 500 ± 420 ml in the HES group versus 465 ± 390 ml in the Gelo group (p = 0.48). No significant differences were observed in any of the routine coagulation tests values, thromboelastometry parameters or number of blood component transfusions between the groups.
  
  
  CONCLUSIONS
  In this randomized, controlled trial of adults after on-pump CABG procedures, there was no significant difference in blood loss or blood coagulation between the HES group and the Gelo group.
authors.affiliation: 1Department of Extracorporeal Circulation, Amphia Hospital, Breda, The Netherlands.
authors.forename: D M
authors.initials: DM
authors.lastname: Kimenai
authors.forename: G W
authors.initials: GW
authors.lastname: Bastianen
authors.forename: C R
authors.initials: CR
authors.lastname: Daane
authors.forename: C M
authors.initials: CM
authors.lastname: Megens-Bastiaanse
authors.forename: N J M
authors.initials: NJ
authors.lastname: van der Meer
authors.forename: T V
authors.initials: TV
authors.lastname: Scohy
authors.forename: B M
authors.initials: BM
authors.lastname: Gerritse
mesh_terms: D000368:Aged; D001777:Blood Coagulation / Q000187:drug effects*; D002315:Cardiopulmonary Bypass / Q000379:methods*; D003102:Colloids / Q000008:administration & dosage*; D005260:Female; D005780:Gelatin / Q000008:administration & dosage*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D007552:Isotonic Solutions / Q000008:administration & dosage; D008297:Male; D000077325:Ringer's Lactate; D013386:Succinates / Q000008:administration & dosage*
chemical_list: D003102:Colloids; C485123:HES 130-0.4; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D013386:Succinates; C060085:succinylated gelatin; D005780:Gelatin
keywords: coagulation; colloids; gelatin; hetastarch; thromboelastography