title: Single molecule SERS and detection of biomolecules with a single gold nanoparticle on a mirror junction.
abstract: Using the bianalyte method we unambiguously demonstrate that a single gold nanosphere on a metal film junction, in the so-called nanoparticle on a mirror configuration, is capable of single molecule detection with surface-enhanced Raman spectroscopy (SERS). Also this configuration serves as a convenient and highly sensitive SERS sensor for detection of biomolecules. Such simple nano-junction based systems are ideal for chemical and biomedical analysis.
authors.affiliation: Institute for Life Sciences, Highfield Campus, University of Southampton, SO17 1BJ, UK.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Tanya
authors.initials: T
authors.lastname: Hutter
authors.forename: Ullrich
authors.initials: U
authors.lastname: Steiner
authors.forename: Sumeet
authors.initials: S
authors.lastname: Mahajan
mesh_terms: D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D006046:Gold