title: Preliminary observations and clinical value of lipid peak in high-grade uterine sarcomas using in vivo proton MR spectroscopy.
abstract: OBJECTIVE
  To retrospectively evaluate the clinical significance of the lipid peak in in vivo proton magnetic resonance spectroscopy (MRS) for the diagnosis of high-grade uterine sarcomas.
  
  
  METHODS
  MRS was performed in patients with 38 pathologically diagnosed uterine corpus tumours (26 leiomyomas and 12 sarcomas) at 3 T. Single-voxel MRS data were collected from a single square volume of interest that encompassed the tumours. The concentrations of lipid and total choline compounds (tCho) were classified as high, low or none.
  
  
  RESULTS
  High lipid peaks were observed in all 12 sarcomas and not in benign leiomyomas except for 1 lipoleiomyoma. All 26 leiomyomas and 10 of the 12 sarcomas showed tCho peaks, whereas 2 sarcomas with massive necrosis showed no tCho peak. The presence of a high lipid peak for the diagnosis of sarcoma had a sensitivity of 100 %, specificity of 96 %, positive predictive value of 92 % and negative predictive value of 100 %.
  
  
  CONCLUSIONS
  The high lipid peaks in high-grade malignant tumours may be observed in both viable and necrotic areas, and may be useful in distinguishing uterine sarcomas from benign leiomyomas.
  
  
  CONCLUSIONS
  • High lipid peak on MR spectroscopy is suggestive of uterine sarcomas. • Lipid peak is observed in both viable and necrotic areas in sarcomas. • MR spectroscopy may be useful in distinguishing uterine sarcomas from benign leiomyomas.
authors.affiliation: Department of Radiology, University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima, zip:7708503, Japan. mayumi@clin.med.tokushima-u.ac.jp
authors.forename: Mayumi
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: Masafumi
authors.initials: M
authors.lastname: Harada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002794:Choline / Q000737:chemistry; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis* / Q000473:pathology*; D008055:Lipids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008875:Middle Aged; D009336:Necrosis; D011237:Predictive Value of Tests; D011522:Protons; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012509:Sarcoma / Q000175:diagnosis* / Q000473:pathology*; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D014599:Uterus / Q000473:pathology; D055815:Young Adult
chemical_list: D008055:Lipids; D011522:Protons; D002794:Choline