title: Use of autologous growth factors in aging tendon and chronic tendinopathy.
abstract: Aging tendons or chronic tendinopathy are frequent conditions responsible for handicap in middle-aged and aging populations. Current therapies fail to relieve handicap. Medical treatment can sometimes be efficient, but surgical procedures often fail to restore tendon function. Cell therapy with platelets, based on tendon histological modifications and the capacity of such tissue to respond to growth factors, is an ever-expanding field of clinical research. In the current review, we compare the histological properties of normal tendons, aging tendons and chronic tendinopathy. We explain the natural healing process of such tendons and the rationale for using, or not, autologous growth factors. We review current clinical studies exploring the effect of concentrated autologous growth factor injection in chronic lesions and attempt to explain why, to date, all clinical studies have demonstrated no effect of such therapies.
authors.affiliation: UR4 Aging, Stress and Inflammation Laboratory, University Pierre and Marie Curie University, Paris, France. gnourissat@wanadoo.fr
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Nourissat
authors.forename: Xavier
authors.initials: X
authors.lastname: Houard
authors.forename: Jeremie
authors.initials: J
authors.lastname: Sellam
authors.forename: Delphine
authors.initials: D
authors.lastname: Duprez
authors.forename: Francis
authors.initials: F
authors.lastname: Berenbaum
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002908:Chronic Disease; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D052256:Tendinopathy / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D036341:Intercellular Signaling Peptides and Proteins