title: Differential lymph node retrieval in rectal cancer: associated factors and effect on survival.
abstract: BACKGROUND
  Recent publications have identified positive associations between numbers of lymph nodes pathologically examined and five-year overall survival (5-yr OS) in colon cancer. However, focused examinations of relationships between survival of rectal cancer and lymph node counts are less common. We conducted a single institution, retrospective review of rectal cancer resections to determine whether lymph node counts correlated with 5-yr OS and to explore the relationship between lymph node counts and various clinical and pathologic factors.
  
  
  METHODS
  A retrospective review of our institutional tumor registry identified 159 patients with AJCC Stage 1, 2, or 3 rectal cancers that underwent surgical resection at our institution over eleven years. Univariate analysis was used to explore the relationship between lymph node counts and age, AJCC Stage, time period of diagnosis, preoperative radiotherapy, and performance of TME. Survival analysis was performed by the Kaplan-Meier method and the Cox proportional hazards model.
  
  
  RESULTS
  In univariate analysis, there was an association between increased lymph node counts and age <70, higher stage, and diagnosis during the later portion of the study period [all P-values <0.05]. Lymph node counts were not associated with survival in Kaplan-Meier analysis or in multivariate Cox proportional hazards analysis.
  
  
  CONCLUSIONS
  Increasing lymph node counts improve survival and the accuracy of colorectal cancer staging. The body of literature recommends identical minimum lymph node counts in both colon and rectal cancer. In our study, which exclusively examined rectal cancer, we could not demonstrate that increased lymph node counts were associated with improved survival.
authors.affiliation: Greenville University Hospital System, USA;
authors.forename: Cedrek
authors.initials: C
authors.lastname: McFadden
authors.forename: Brian
authors.initials: B
authors.lastname: McKinley
authors.forename: Brian
authors.initials: B
authors.lastname: Greenwell
authors.forename: Kaylee
authors.initials: K
authors.lastname: Knuckolls
authors.forename: Patrick
authors.initials: P
authors.lastname: Culumovic
authors.forename: David
authors.initials: D
authors.lastname: Schammel
authors.forename: Christine
authors.initials: C
authors.lastname: Schammel
authors.forename: Steven D
authors.initials: SD
authors.lastname: Trocha
keywords: Lymph node; rectal cancer; univariate analysis