title: [Vascular endothelial growth factor in malignant and non malignant prostatic tissue: Association with tumor recurrence at one year after prostatectomy].
abstract: BACKGROUND
  Prostate cancer (PC) is the second cause of death by cancer in men in Chile. Its behavior is so variable that it is necessary to search reliable prognostic markers. Vascular Endothelial Growth Factor (VEGF) is one of the most powerful pro-angiogenic factors. There is no agreement on its validity as a diagnostic or prognostic factor.
  
  
  OBJECTIVE
  To search for VEFG in prostatic tissue.
  
  
  METHODS
  This study was performed in prostatectomy tissue coming from 41 patients with PC and 39 patients with benign prostatic hyperplasia (BPH). Specimens were studied using immunohistochemical staining for VEGF. The percentage of stained glandular cells per patient was calculated and associated with pathological diagnosis in cancer patients.
  
  
  RESULTS
  PC biopsies had a mean of 82% of VEGF (+) stained cells, while BPH had only 1.6% (p < 0.01). No relationship was found between the percentage of staining and recurrence at one year of follow-up in the case of PC.
  
  
  CONCLUSIONS
  These results would rule out VEGF as a prognostic factor in this series of patients.
authors.affiliation: Departamento de Urología, Corporación Nacional del Cáncer, Valparaíso, Chile.
authors.forename: Pedro
authors.initials: P
authors.lastname: Acuña
authors.forename: Andrés
authors.initials: A
authors.lastname: Ellwanger
authors.forename: Angela
authors.initials: A
authors.lastname: Ramírez
authors.forename: Felipe
authors.initials: F
authors.lastname: Cardemil
authors.forename: Jorge
authors.initials: J
authors.lastname: Vega
authors.forename: Renato
authors.initials: R
authors.lastname: Casalino
authors.forename: Eva
authors.initials: E
authors.lastname: Madrid
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000737:chemistry*; D011237:Predictive Value of Tests; D011467:Prostate / Q000737:chemistry* / Q000473:pathology; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D011471:Prostatic Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A