title: Special article: evaluation of a novel noninvasive respiration monitor providing continuous measurement of minute ventilation in ambulatory subjects in a variety of clinical scenarios.
abstract: BACKGROUND
  Currently there is no technology that noninvasively measures the adequacy of ventilation in nonintubated patients. A novel, noninvasive Respiratory Volume Monitor (RVM) has been developed to continuously measure and display minute ventilation (MV), tidal volume (TV), and respiratory rate (RR) in a variety of clinical settings. We demonstrate the RVM's accuracy and precision as compared with a standard spirometer under a variety of clinically relevant breathing patterns in nonintubated subjects.
  
  
  METHODS
  Thirty-one voluntary subjects completed the primary study. MV, TV, and RR measurements were collected from the RVM and spirometer simultaneously for each participant on day 1 and day 2 and analyzed to determine accuracy, precision, and bias for normal, fast, slow, irregular, and closed-glottis breathing.
  
  
  RESULTS
  Data demonstrated that RVM and spirometer measurements of MV and TV are equivalent in a wide range of ambulatory subjects with an average error <10% (95% confidence interval for accuracy <16%, precision <12%, and bias <11%). Repeated measures analysis of variance found no significant difference between spirometry and RVM individual measurements of MV, TV, and RR (P > 0.7), whereas a paired-difference equivalent test demonstrated, with 99% power, that both MV and TV measurements from the 2 devices are equivalent within ±15%.
  
  
  CONCLUSIONS
  This study demonstrates RVM's clinically relevant accuracy and precision in measuring MV, TV, and RR over a 24-hour period and during various breathing patterns.
authors.affiliation: Respiratory Motion, Inc., 411 Waverley Oaks Rd., Building 1, Suite 150, Waltham, MA 02452, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Voscopoulos
authors.forename: Jordan
authors.initials: J
authors.lastname: Brayanov
authors.forename: Diane
authors.initials: D
authors.lastname: Ladd
authors.forename: Michael
authors.initials: M
authors.lastname: Lalli
authors.forename: Alexander
authors.initials: A
authors.lastname: Panasyuk
authors.forename: Jenny
authors.initials: J
authors.lastname: Freeman
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements / Q000379:methods; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods / Q000592:standards*; D063087:Noninvasive Ventilation / Q000379:methods / Q000592:standards*; D013990:Tidal Volume / Q000502:physiology*