title: Body weight difference between donor and recipient is an important affector of early graft function after renal transplantation.
abstract: BACKGROUND
  Poor early graft function (EGF), a frequent complication of kidney transplantation, can be caused by many risk factors, including donor kidney and body weights.
  
  
  METHODS
  We studied the relationship to early graft function in a rat kidney transplantation model among 3 indices: ratio of graft to body weight; ratio of native kidney to body weight, and weight difference/body weight of the recipient. We categorized 2 groups based on contralateral nephrectomy at day 1 (G1) or day 3 (G2) after transplantation. EGF was evaluated by measuring serum creatinine levels at day 1 after bilateral nephrectomy.
  
  
  RESULTS
  The 3 indices, ie, weight difference/body weight of recipient (G1 and G2: P < .0001), ratio of native kidney to body weight (G1: P < .0001; G2: P = .0013), and ratio of graft to body weight (G1: P = .0064; G2: P = .014) strongly correlated with EGF regardless of the time of contralateral nephrectomy.
  
  
  CONCLUSIONS
  The index of weight difference/body weight of recipient sensitively and predominantly influenced EGF, which probably reflects the systemic metabolic profile.
authors.affiliation: Department of General Surgery, Transplant Laboratory, 2(nd) Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, China.
authors.forename: F
authors.initials: F
authors.lastname: Ge
authors.forename: W
authors.initials: W
authors.lastname: Gong
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001835:Body Weight; D003404:Creatinine / Q000097:blood; D051799:Delayed Graft Function / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D023421:Models, Animal; D009392:Nephrectomy / Q000009:adverse effects; D009929:Organ Size; D051381:Rats; D011917:Rats, Inbred Lew; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors
chemical_list: D015415:Biomarkers; D003404:Creatinine