title: [Prevention of congenital toxoplasmosis in a Buenos Aires hospital].
abstract: The prevention of congenital toxoplasmosis is based on providing information to women, serologic diagnosis and treatment of the infected mother and child. In this article we present the results of 12 years of implementation of a congenital toxoplasmosis prevention program in which we measured the mother's infection incidence rate, the transmission rate and the number and severity of infection in newborns. The study was performed on 12035 pregnant women in the period 2000-2011. The prevalence rate of antibodies against Toxoplasma gondii was 18.33% (2206/12035). Thirty-seven out of 9792 susceptible women presented acute infection and the mother's infection incidence rate was 3.78 per 1000 births. The transplacental transmission rate was 5.4% (2/37). Two newborns presented congenital toxoplasmosis infection, one had no clinical signs while the other presented strabismus and chorioretinitis. Thirty-five infected mothers and the two children with congenital infection were treated. The transmission rates obtained allow consider this prevention program as a valid resource to minimize the impact of congenital toxoplasmosis.
authors.affiliation: Centro de Toxoplasmosis y otras Zoonosis, Hospital Alemán de Buenos Aires, Argentina. labtox@hospitalaleman.com
authors.forename: Liliana
authors.initials: L
authors.lastname: Carral
authors.forename: Federico
authors.initials: F
authors.lastname: Kaufer
authors.forename: Patricia
authors.initials: P
authors.lastname: Olejnik
authors.forename: Cristina
authors.initials: C
authors.lastname: Freuler
authors.forename: Ricardo
authors.initials: R
authors.lastname: Durlach
mesh_terms: D000913:Antibodies, Protozoan / Q000097:blood; D001118:Argentina / Q000453:epidemiology; D002675:Child, Preschool; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006078:Government Programs; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007163:Immunosorbent Techniques; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D011446:Prospective Studies; D014122:Toxoplasma / Q000276:immunology; D014123:Toxoplasmosis / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis / Q000517:prevention & control* / Q000635:transmission
chemical_list: D000913:Antibodies, Protozoan; D007136:Immunoglobulins
keywords: congenital toxoplasmosis; prevention; serology