title: Melanoma metastasis: new concepts and evolving paradigms.
abstract: Melanoma progression is typically depicted as a linear and stepwise process in which metastasis occurs relatively late in disease progression. Significant evidence suggests that in a subset of melanomas, progression is much more complex and less linear in nature. Epidemiologic and experimental observations in melanoma metastasis are reviewed here and are incorporated into a comprehensive model for melanoma metastasis, which takes into account the varied natural history of melanoma formation and progression.
authors.affiliation: 1] Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA [2] Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA.
authors.forename: W E
authors.initials: WE
authors.lastname: Damsky
authors.affiliation: Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: N
authors.initials: N
authors.lastname: Theodosakis
authors.affiliation: Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: M
authors.initials: M
authors.lastname: Bosenberg
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D008545:Melanoma / Q000556:secondary*; D009362:Neoplasm Metastasis / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*