title: Tandem Ru-alkylidene-catalysed cross metathesis/hydrogenation: synthesis of lipophilic amino acids.
abstract: Highly efficient synthesis of lipidic amino acids can be achieved via Ru-alkylidene-catalysed cross metathesis of long chain alkenes with commercially available allylglycine. The resultant unsaturated analogues can be then optionally hydrogenated under mild reaction conditions by using the spent metathesis catalyst.
authors.affiliation: School of Chemistry, Monash University, Wellington Road, Melbourne, 3800, Victoria, Australia.
authors.forename: Zhen J
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Nicolas D
authors.initials: ND
authors.lastname: Spiccia
authors.forename: W Roy
authors.initials: WR
authors.lastname: Jackson
authors.forename: Andrea J
authors.initials: AJ
authors.lastname: Robinson
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D001597:Benzylidene Compounds / Q000737:chemistry*; D002384:Catalysis; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry; D006865:Hydrogenation; D057927:Hydrophobic and Hydrophilic Interactions; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000596:Amino Acids; D001597:Benzylidene Compounds; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D012428:Ruthenium
keywords: cross metathesis; hydrogenation; lipophilic amino acids; tandem catalysis