title: The associations between the polymorphisms of the ER-α gene and the risk of uterine leiomyoma (ULM).
abstract: The ER-α gene polymorphisms have been reported to be associated with uterine leiomyoma (ULM) risk. The purpose of the present study was to perform a meta-analysis to explore the polymorphisms in the ER-α gene and the risk of ULM. A comprehensive search for relevant articles was conducted in MEDLINE (Ovid), PubMed, Embase, Springer, EBSCO, Web of Science, CNKI, Wanfang, Weipu, and Google Scholar. A total of nine articles were identified. Among the nine articles, 11 cohorts reported the PvuII polymorphism and six reported the XbaI polymorphism. The strength of the relationships between the polymorphisms in ER-α (PvuII and XbaI) and the risk of ULM was assessed by odds ratios (ORs). The studies provided overall OR estimates for PvuII and XbaI, leading to a pooled OR of 1.41 (PP+Pp vs. pp: OR = 1.41, 95 % confidence interval (95 %CI) = 1.02-1.96, P = 0.04), 1.13 (XX+Xx vs. xx: OR = 1.13, 95 %CI = 0.91-1.41, P = 0.25), respectively. The PvuII polymorphism in the ER-α gene may be a risk factor for ULM. Future studies are needed to validate our conclusions.
authors.affiliation: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, No. 20, Section 3, South People's Road, Chengdu, 610041, Sichuan, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Lin
authors.forename: Shengtao
authors.initials: S
authors.lastname: Zhou
authors.forename: Ning
authors.initials: N
authors.lastname: Xu
authors.forename: Tao
authors.initials: T
authors.lastname: Yi
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
mesh_terms: D016022:Case-Control Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D016017:Odds Ratio; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000235:genetics*
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha