title: Double-blind placebo-controlled trial of hydroxytyrosol of Olea europaea on pain in gonarthrosis.
abstract: Hydroxytyrosol is mainly found in olive leaves after hydrolysis of oleuropein and has anti-oxidant, anti-bacterial, and anti-inflammatory properties. The aim of this study was to investigate the effect of hydroxytyrosol for alleviating the pain in patients with gonarthrosis. We conducted a double-blind clinical trial in which hydroxytyrosol or placebo was administered to adult patients with gonarthrosis for 4 weeks. The group administered hydroxytyrosol showed significant improvement in the Japanese Orthopedic Association score (pain measurement index) and the visual analog scale score compared to the placebo group.
authors.affiliation: Faculty of Agriculture, Kinki University, 3327-204 Nakamachi, Nara 631-8505, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Takeda
authors.forename: Taisuke
authors.initials: T
authors.lastname: Koike
authors.forename: Itaru
authors.initials: I
authors.lastname: Taniguchi
authors.forename: Keiko
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D031658:Olea; D020370:Osteoarthritis, Knee / Q000188:drug therapy*; D010147:Pain Measurement; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D010936:Plant Extracts; C005975:3,4-dihydroxyphenylethanol; D010626:Phenylethyl Alcohol
keywords: Gonarthrosis; Hydroxytyrosol; Olea europaea; Olive; Pain