title: A longitudinal study of PSA and its influential factors in a cohort of Chinese men with initial PSA levels less than 4 ng ml(-1).
abstract: To evaluate the longitudinal change in prostate-specific antigen (PSA) and the influence of initial PSA on the PSA change. We retrospectively analysed health examination data collected at Beijing Hospital from March 2007 to November 2011. Men with an initial PSA levels less than 4 ng ml(-1) and an annual PSA test for 5 years were enrolled into the study. The men were separated into four groups by the initial PSA level (0-0.99, 1-1.99, 2-2.99 and 3-3.99 ng ml(-1)), and the difference in PSA change among the four groups was analysed. A total of 1330 men were enrolled into the study. The mean age, initial PSA and PSA velocity (PSAV) were 58.17 ± 14.63 (range 24-91) years, 1.18 ± 0.79 (range 0-4) ng ml(-1) and 0.04 ± 0.25 (range -1.34-2.02) ng ml(-1) year(-1). Pearson's correlation analysis showed no correlation between initial PSA and PSAV (r=-0.036, P=0.189). The PSAV of the 0-0.99, 1-1.99, 2-2.99 and 3-3.99 ng ml(-1) initial PSA groups was 0.03 ± 0.11, 0.07 ± 0.32, 0.03 ± 0.34 and -0.01 ± 0.43 ng ml(-1) year(-1), respectively (P=0.06). As the initial PSA increased, the percentage of having a PSAV over 0.75 ng ml(-1) year(-1) and a negative PSAV both significantly increased. Males with a baseline PSA of 0-0.99, 1-1.99, 2-2.99 and 3-3.99 ng ml(-1) had a 1.88%, 6.16%, 16.30% and 57.81% chance, respectively, that their PSA would increase above 4.0 ng ml(-1) over the following 4 years (P<0.0001). The PSAV has no correlation with the initial PSA level. However, as the initial PSA increases, the chance that males will have an abnormal PSA or PSAV in the future increases.
authors.affiliation: Beijing Hospital, Department of Urology, Beijing 100730, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Jian-Ye
authors.initials: JY
authors.lastname: Wang
authors.forename: Hong-Xue
authors.initials: HX
authors.lastname: Su
authors.forename: Gang
authors.initials: G
authors.lastname: Wan
authors.forename: Ling
authors.initials: L
authors.lastname: Zhu
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000706:statistics & numerical data*; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D007610:Kallikreins / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000208:ethnology*; D012189:Retrospective Studies; D012307:Risk Factors; D014505:Urban Population / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen