title: Eradication of breast cancer with bone metastasis by autologous formalin-fixed tumor vaccine (AFTV) combined with palliative radiation therapy and adjuvant chemotherapy: a case report.
abstract: Skeletal metastasis of breast carcinoma is refractory to intensive chemo-radiation therapy and therefore is assumed impossible to cure. Here, we report an advanced case of breast cancer with vertebra-Th7 metastasis that showed complete response to combined treatments with formalin-fixed autologous tumor vaccine (AFTV), palliative radiation therapy with 36 Gy, and adjuvant chemotherapy with standardized CEF (cyclophosphamide, epirubicin, and 5FU), zoledronic acid, and aromatase inhibitors following mastectomy for the breast tumor. The patient has been disease-free for more than 4 years after the mammary surgery and remains well with no evidence of metastasis or local recurrence. Thus, a combination of AFTV, palliative radiation therapy, and adjuvant chemotherapy may be an effective treatment for this devastating disease.
authors.affiliation: Department of Surgery, Innoshima-Ishikai Hospital, Innoshima, Onomichi, Hiroshima 722-2211, Japan. ishikai@beach.ocn.ne.jp
authors.forename: Fumito
authors.initials: F
authors.lastname: Kuranishi
authors.forename: Tadao
authors.initials: T
authors.lastname: Ohno
mesh_terms: D000077384:Anastrozole; D000730:Androstadienes / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001324:Autoantigens / Q000008:administration & dosage; D001859:Bone Neoplasms / Q000556:secondary / Q000628:therapy*; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D019496:Cancer Vaccines / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004164:Diphosphonates / Q000008:administration & dosage; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D005404:Fixatives; D005472:Fluorouracil / Q000008:administration & dosage; D005557:Formaldehyde / Q000008:administration & dosage; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D009570:Nitriles / Q000008:administration & dosage; D011379:Prognosis; D011879:Radiotherapy Dosage; D015899:Tomography, Emission-Computed, Single-Photon; D014230:Triazoles / Q000008:administration & dosage; D000077211:Zoledronic Acid
chemical_list: D000730:Androstadienes; D001324:Autoantigens; D019496:Cancer Vaccines; D004164:Diphosphonates; D005404:Fixatives; D007093:Imidazoles; D009570:Nitriles; D014230:Triazoles; D005557:Formaldehyde; D000077384:Anastrozole; D015251:Epirubicin; D000077211:Zoledronic Acid; D003520:Cyclophosphamide; C056516:exemestane; D005472:Fluorouracil