title: Maternal dietary intake during pregnancy has longstanding consequences for the health of her offspring.
abstract: Over the past 100 years, advances in pharmaceutical and medical technology have reduced the burden of communicable disease, and our appreciation of the mechanisms underlying the development of noncommunicable disease has broadened. During this time, a number of studies, both in humans and animal models, have highlighted the importance of maintaining an optimal diet during pregnancy. In particular, a number of studies support the hypothesis that suboptimal maternal protein and fat intake during pregnancy can have long-term effects on the growing fetus, and increase the likelihood of these offspring developing cardiovascular, renal, or metabolic diseases in adulthood. More recently, it has been shown that dietary intake of a number of micronutrients may offset or reverse the deleterious effects of macronutrient imbalance. Furthermore, maternal fat intake has also been identified as a major contributor to a healthy fetal environment, with a beneficial role for unsaturated fats during development as well as a beneficial impact on cell membrane physiology. Together these studies indicate that attempts to optimise maternal nutrition may prove to be an efficient and cost-effective strategy for preventing the development of cardiovascular, renal, or metabolic diseases.
authors.affiliation: Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Ryan James
authors.initials: RJ
authors.lastname: Wood-Bradley
authors.forename: Sarah Louise
authors.initials: SL
authors.lastname: Henry
authors.forename: Amanda
authors.initials: A
authors.lastname: Vrselja
authors.forename: Victoria
authors.initials: V
authors.lastname: Newman
authors.forename: James Andrew
authors.initials: JA
authors.lastname: Armitage
mesh_terms: D001724:Birth Weight / Q000502:physiology; D002149:Energy Intake / Q000502:physiology*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage; D005260:Female; D047109:Fetal Development / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D044342:Malnutrition / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D039382:Maternal Nutritional Physiological Phenomena; D018977:Micronutrients / Q000008:administration & dosage; D044343:Overnutrition / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology / Q000517:prevention & control*
chemical_list: D005231:Fatty Acids, Unsaturated; D018977:Micronutrients