title: Trichloroacetic acid application versus spray monopolar diathermy for treating benign cervical lesions: a randomized controlled clinical trial.
abstract: OBJECTIVE
  This study aimed to compare efficacy, tolerability, and safety of trichloroacetic acid (TCA) painting versus monopolar spray coagulation of the cervix for treating persistent benign cervical lesions.
  
  
  METHODS
  A prospective randomized controlled trial was done in a tertiary care referral facility and university hospital. A total of 246 cases with objective evidence of benign cervical lesions were divided into 2 groups according to the line of management. Group A was composed of 126 cases subjected to spray monopolar coagulation, whereas group B was composed of 120 cases subjected to TCA application. Cervical smearing and colposcopy with or without cervical biopsy were performed to exclude underlying malignant lesions. Trichloroacetic acid painting or spray monopolar coagulation of the benign cervical lesion(s) was also performed. Follow-up was performed to assess relief of symptoms and cervical morphology for 1 month. Main outcome measures include success of management tool, relief of symptoms, and normal cervical morphology after 1 month of therapy.
  
  
  RESULTS
  A statistically significant cure rate of cervical lesions after treatment in both groups without significant difference between both groups was reported. Failure rate was reported more in group B than group A mainly owing to hypertrophied ectopy and cervical polyp. Patient in group A reported low satisfaction (26.9%) and poor tolerability rate (44.5%) as compared with patients in group B, who reported high satisfaction (77.5%) and good tolerability rate (77.5%), this difference was statistically significant.
  
  
  CONCLUSIONS
  Both topical application of 70% TCA and monopolar spray coagulation offer considerable efficacy, acceptable success rates, and minimal complications. Spray coagulation is significantly superior in terms of less persistent or incompletely healed lesions. Nevertheless, topical application of 70% TCA has the advantages of simplicity, higher patient tolerability, and safety, which can be widely used by gynecologists who have limited experience with surgical procedures. It is highly recommended if the cervical lesion is ectopy or nonspecific cervicitis but not hypertrophic lesion such as hypertrophic ectopy or polyp.
authors.affiliation: Woman's Health University Center, Assiut University, Assiut, Egypt. atef_darwish@yahoo.com
authors.forename: Atef Mohammad M
authors.initials: AM
authors.lastname: Darwish
authors.forename: Kamal M
authors.initials: KM
authors.lastname: Zahran
mesh_terms: D000328:Adult; D003127:Colposcopy; D003972:Diathermy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011446:Prospective Studies; D016896:Treatment Outcome; D014238:Trichloroacetic Acid / Q000009:adverse effects* / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000628:therapy*; D014626:Vaginal Smears; D055815:Young Adult
chemical_list: D014238:Trichloroacetic Acid