title: Dihydrochalcones with antiinflammatory activity from leaves and twigs of Cyathostemma argenteum.
abstract: A new dihydrochalcone derivative, 4',6'-dihydroxy-2',4-dimethoxy-5'-(2''-hydroxybenzyl)dihydrochalcone (1) and one known dihydrochalcone, 4',6'-dihydroxy-2',4- dimethoxydihydrochalcone (2) were isolated from leaves and twigs of Cyathostemma argenteum. Their structures were established by spectral methods, mainly 2D NMR spectroscopic techniques, which involved combined applications of DEPT, COSY, HMQC and HMBC. The molecular structure of 1 was also confirmed by single crystal X-ray diffraction. The test compounds 1 and 2 displayed signiﬁcant inhibitory activity at a dose of 1 mg/ear on edema formation at all determination times, with similar intensity as phenylbutazone.
authors.affiliation: Laboratory of Natural Products, Faculty of Science and Center for Innovation in Chemistry, Lampang Rajabhat University, Lampang 52100, Thailand.
authors.forename: Jariya
authors.initials: J
authors.lastname: Somsrisa
authors.forename: Puttinan
authors.initials: P
authors.lastname: Meepowpan
authors.forename: Samroeng
authors.initials: S
authors.lastname: Krachodnok
authors.forename: Haruthai
authors.initials: H
authors.lastname: Thaisuchat
authors.forename: Sittiporn
authors.initials: S
authors.lastname: Punyanitya
authors.forename: Narong
authors.initials: N
authors.lastname: Nantasaen
authors.forename: Wilart
authors.initials: W
authors.lastname: Pompimon
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D047188:Chalcones / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D006860:Hydrogen Bonding; D008297:Male; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D047188:Chalcones; D010936:Plant Extracts; C015812:dihydrochalcone