title: Hypofractionated intensity-modulated radiotherapy with simultaneous integrated boost after radical prostatectomy: preliminary results of a phase II trial.
abstract: OBJECTIVE
  To report the acute toxicity of a hypofractionated regimen of intensity-modulated radiotherapy with simultaneous integrated boost (SIB-IMRT) to the pelvic nodes and the prostatic bed after radical prostatectomy.
  
  
  METHODS
  Patients with prostate adenocarcinoma at high risk of relapse after radical prostatectomy or with biochemical relapse were deemed eligible for study. SIB-IMRT was prescribed to the whole pelvis (45-Gy delivered in 1.8-Gy fractions) and the prostatic bed [62.5 Gy, 2.5-Gy fractions, Equivalent Dose in 2-Gy fraction (EQD2)=68.75 Gy, α/β=3]. Acute toxicity was recorded and graded according to Radiation Therapy Oncology Group (RTOG) criteria.
  
  
  RESULTS
  Forty-nine patients were enrolled. No cases of grade ≥ 3 acute toxicity were recorded. Grade 2 acute genitourinary and gastrointestinal toxicity was observed in 9.6% and 29.7% of patients, respectively.
  
  
  CONCLUSIONS
  After radical prostatectomy, hypofractionated high-dose SIB-IMRT enables for reduction of the overall treatment time, with an acute toxicity profile which compares favourably with that of conventionally fractionated high-dose three-dimensional conformal radiotherapy (3D-CRT).
authors.affiliation: Radiotherapy Unit, Department of Oncology, Giovanni Paolo II Fondazione di Ricerca e Cura, Campobasso, Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Massaccesi
authors.forename: Savino
authors.initials: S
authors.lastname: Cilla
authors.forename: Francesco
authors.initials: F
authors.lastname: Deodato
authors.forename: Cinzia
authors.initials: C
authors.lastname: Digesù
authors.forename: Gabriella
authors.initials: G
authors.lastname: Macchia
authors.forename: Luciana
authors.initials: L
authors.lastname: Caravatta
authors.forename: Edy
authors.initials: E
authors.lastname: Ippolito
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Picardi
authors.forename: Marica
authors.initials: M
authors.lastname: Ferro
authors.forename: Samantha
authors.initials: S
authors.lastname: Mignogna
authors.forename: Gian Carlo
authors.initials: GC
authors.lastname: Mattiucci
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Valentini
authors.forename: Angelo
authors.initials: A
authors.lastname: Piermattei
authors.forename: Alessio Giuseppe
authors.initials: AG
authors.lastname: Morganti
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy* / Q000601:surgery*; D000368:Aged; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D005767:Gastrointestinal Diseases; D006801:Humans; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D011832:Radiation Injuries; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects
keywords: Post-operative radiotherapy; SIB-IMRT; hypofractionation; phase II trial; prostate cancer