title: Two new neolignans from Patrinia scabra with potent cytotoxic activity against HeLa and MNK-45 cells.
abstract: Two new neolignans, patrineolignan A (1) and patrineolignan B (2), together with seven known lignans, were isolated from the 90 % aqueous EtOH extract of the roots of Patrinia scabra. Their structures were elucidated on the basis of spectroscopic data (HRESIMS, IR, 1D and 2D NMR) and comparison with literature data. The two new neolignans were evaluated in vitro for cytotoxic properties against human cervical carcinoma HeLa cell line and gastric carcinoma MNK-45 cell line using the microculture tetrazolium assay, and both 1 and 2 exhibited strongly cytotoxic activity against the two tumor cell lines.
authors.affiliation: Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Di
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Yan
authors.forename: Ling-Yu
authors.initials: LY
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Ma
authors.forename: Kai-Jin
authors.initials: KJ
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D045744:Cell Line, Tumor; D006367:HeLa Cells; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D015394:Molecular Structure; D032405:Patrinia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity*; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D010936:Plant Extracts