title: Fatal encephalitis due to BK virus in a patient with common variable immunodeficiency: a case report.
abstract: Encephalitis due to BK virus is a rare condition. Here, we describe a young male patient with common variable immunodeficiency who developed fatal encephalitis due to BK virus. The patient presented initially with ocular symptoms that were followed by behavioral changes and spastic quadriparesis. Diagnosis was made by the compatible clinical findings and detection of viral DNA by polymerase chain reaction in the cerebrospinal fluid. To the best of our knowledge, this is the first report of BK virus encephalitis in a patient with common variable immunodeficiency. We suggest that BK virus should be suspected in cases of encephalitis; particularly in patients with immunodeficiency.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, The University of Jordan, PO Box 13046, Amman 11942, Jordan. fbakri@yahoo.com
authors.forename: Faris G
authors.initials: FG
authors.lastname: Bakri
authors.forename: Yacoub G
authors.initials: YG
authors.lastname: Bahou
authors.forename: Firas A
authors.initials: FA
authors.lastname: Al-Sammarrai
authors.forename: Azmy
authors.initials: A
authors.lastname: Hadidy
authors.forename: Almutez
authors.initials: A
authors.lastname: Gharaibeh
authors.forename: Ghida K
authors.initials: GK
authors.lastname: Zaid
authors.forename: Azmi
authors.initials: A
authors.lastname: Mahafzah
authors.forename: Osama A
authors.initials: OA
authors.lastname: Samara
authors.forename: Nidaa A
authors.initials: NA
authors.lastname: Ababneh
authors.forename: Imad
authors.initials: I
authors.lastname: Zak
mesh_terms: D000328:Adult; D001739:BK Virus / Q000235:genetics / Q000302:isolation & purification*; D017074:Common Variable Immunodeficiency / Q000276:immunology / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D018792:Encephalitis, Viral / Q000276:immunology* / Q000821:virology*; D006801:Humans; D008297:Male; D027601:Polyomavirus Infections / Q000276:immunology* / Q000821:virology; D014412:Tumor Virus Infections / Q000276:immunology* / Q000821:virology; D055815:Young Adult
chemical_list: D004279:DNA, Viral