title: Association mapping of quantitative trait loci for carcass and meat quality traits at the central part of chromosome 2 in Italian Large White pigs.
abstract: Association mapping of the central part of porcine chromosome 2 harboring QTLs for carcass and meat quality traits was performed with 17 gene-tagged SNPs located between 44.0 and 77.5 Mb on a physical map (Sscrofa10.2) in Italian Large White pigs. For the analyzed animals records of estimated breeding values for average daily gain, back fat thickness, lean cuts, ham weight, feed conversion ratio, pH1, pHu, CIE L*, CIE a*, CIE b* and drip loss were available. A significant QTL for fat deposition (adjusted P=0.0081) and pH1 (adjusted P=0.0972) to MYOD1 at position 44.4 Mb and a QTL for growth and meatiness (adjusted P=0.0238-0.0601) to UBL5 at position 68.9 Mb were mapped. These results from association mapping are much more accurate than those from linkage mapping and facilitate further search for position candidate genes and causative mutations needed for application of markers through marker assisted selection.
authors.affiliation: Institute of Animal Physiology and Genetics, The Academy of Sciences of the Czech Republic, Liběchov, Czech Republic. cepica@email.cz
authors.forename: S
authors.initials: S
authors.lastname: Cepica
authors.forename: P
authors.initials: P
authors.lastname: Zambonelli
authors.forename: F
authors.initials: F
authors.lastname: Weisz
authors.forename: M
authors.initials: M
authors.lastname: Bigi
authors.forename: A
authors.initials: A
authors.lastname: Knoll
authors.forename: Z
authors.initials: Z
authors.lastname: Vykoukalová
authors.forename: M
authors.initials: M
authors.lastname: Masopust
authors.forename: M
authors.initials: M
authors.lastname: Gallo
authors.forename: L
authors.initials: L
authors.lastname: Buttazzoni
authors.forename: R
authors.initials: R
authors.lastname: Davoli
mesh_terms: D000818:Animals; D001835:Body Weight; D001947:Breeding; D002874:Chromosome Mapping / Q000379:methods*; D005260:Female; D063427:Food Quality; D006863:Hydrogen-Ion Concentration; D008297:Male; D008460:Meat / Q000032:analysis*; D017570:MyoD Protein / Q000235:genetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D013552:Swine / Q000235:genetics*
chemical_list: D017570:MyoD Protein; C057363:MyoD1 myogenic differentiation protein