title: Concise review: role of DEK in stem/progenitor cell biology.
abstract: Understanding the factors that regulate hematopoiesis opens up the possibility of modifying these factors and their actions for clinical benefit. DEK, a non-histone nuclear phosphoprotein initially identified as a putative proto-oncogene, has recently been linked to regulate hematopoiesis. DEK has myelosuppressive activity in vitro on proliferation of human and mouse hematopoietic progenitor cells and enhancing activity on engraftment of long-term marrow repopulating mouse stem cells, has been linked in coordinate regulation with the transcription factor C/EBPα, for differentiation of myeloid cells, and apparently targets a long-term repopulating hematopoietic stem cell for leukemic transformation. This review covers the uniqueness of DEK, what is known about how it now functions as a nuclear protein and also as a secreted molecule that can act in paracrine fashion, and how it may be regulated in part by dipeptidylpeptidase 4, an enzyme known to truncate and modify a number of proteins involved in activities on hematopoietic cells. Examples are provided of possible future areas of investigation needed to better understand how DEK may be regulated and function as a regulator of hematopoiesis, information possibly translatable to other normal and diseased immature cell systems.
authors.affiliation: Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana. hbroxmey@iupui.edu.
authors.forename: Hal E
authors.initials: HE
authors.lastname: Broxmeyer
authors.forename: Nirit
authors.initials: N
authors.lastname: Mor-Vaknin
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Kappes
authors.forename: Maureen
authors.initials: M
authors.lastname: Legendre
authors.forename: Anjan K
authors.initials: AK
authors.lastname: Saha
authors.forename: Xuan
authors.initials: X
authors.lastname: Ou
authors.forename: Heather
authors.initials: H
authors.lastname: O'Leary
authors.forename: Maegan
authors.initials: M
authors.lastname: Capitano
authors.forename: Scott
authors.initials: S
authors.lastname: Cooper
authors.forename: David M
authors.initials: DM
authors.lastname: Markovitz
mesh_terms: D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D015513:Oncogene Proteins / Q000502:physiology*; D000075223:Poly-ADP-Ribose Binding Proteins; D000090063:Proto-Oncogene Mas
chemical_list: D002868:Chromosomal Proteins, Non-Histone; C519564:DEK protein, mouse; D004268:DNA-Binding Proteins; C084738:DEK protein, human; C000715470:MAS1 protein, human; D015513:Oncogene Proteins; D000075223:Poly-ADP-Ribose Binding Proteins; D000090063:Proto-Oncogene Mas
keywords: Chromatin; DEK; Dipeptidylpeptidase IV; Hematopoietic progenitor cells; Hematopoietic stem cells; Receptors