title: Prolidase activity in patients with coronary artery aneurysm.
abstract: Decreased collagen biosynthesis and increased collagenolysis may induce aneurysmal progress in arterial walls. Prolidase plays a role in collagen synthesis. In this study, we sought to evaluate whether there is a correlation between nonatherosclerotic coronary artery aneurysms (CAAs) and prolidase activity. A total of 174 CAAs were diagnosed in 144 (2.1%) patients among 6845 coronary angiographies performed between 2009 and 2012. In all, 23 (15.9%) patients had nonatherosclerotic aneurysms. Prolidase activity was compared to the results of 19 healthy volunteers with normal coronary arteries. Demographic parameters were similar between the groups. Mean prolidase activity was 241.6 ± 54.4 mU/mL in the coronary aneurysm group and 730.3 ± 243.1 mU/mL in the control group (P < .001). The incidence of CAAs ranges between 0.3% and 5.3% in the general population. Decreased prolidase activity may reduce collagen biosynthesis that may contribute to aneurysm formation.
authors.affiliation: Department of Cardiovascular Surgery, Bakirkoy Dr Sadi Konuk Education and Research Hospital, Istanbul, Turkey vedatbakuy@yahoo.com.
authors.forename: Vedat
authors.initials: V
authors.lastname: Bakuy
authors.affiliation: Department of Cardiovascular Surgery, Bakirkoy Dr Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: Mete
authors.initials: M
authors.lastname: Gursoy
authors.affiliation: Department of Cardiovascular Surgery, Medical Park Hospital, Istanbul, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Hokenek
authors.affiliation: Department of Biochemistry, Bakirkoy Dr Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: Asuman
authors.initials: A
authors.lastname: Gedikbasi
authors.affiliation: Department of Cardiovascular Surgery, Bakirkoy Dr Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Atay
authors.affiliation: Department of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Nurdag
authors.affiliation: Department of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: Ilker Murat
authors.initials: IM
authors.lastname: Caglar
authors.affiliation: Department of Cardiovascular Surgery, Anadolu Medical Center Hospital, Kocaeli, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ugurlucan
authors.affiliation: Department of Cardiovascular Surgery, Bakirkoy Dr Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Akgul
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001773:Blood Cells / Q000166:cytology; D003323:Coronary Aneurysm / Q000201:enzymology*; D017023:Coronary Angiography / Q000379:methods; D003331:Coronary Vessels / Q000201:enzymology / Q000473:pathology*; D004150:Dipeptidases / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004150:Dipeptidases; C022449:proline dipeptidase
keywords: coronary aneurysm; prolidase; proline dipeptidase