title: Serum dehydroepiandrosterone sulphate, total antioxidant capacity, and total oxidant status in central serous chorioretinopathy.
abstract: BACKGROUND
  The objective of this work is to evaluate plasma total antioxidant capacity (TAC), total oxidant status (TOS), and dehydroepiandrosterone sulphate (DHEA-S) levels in patients diagnosed with acute central serous chorioretinopathy (CSCR) and control samples.
  
  
  METHODS
  The TAC, TOS, and DHEA-S levels were assessed in the plasma of 46 CSCR patients and compared with 40 control samples.
  
  
  RESULTS
  The TAC level was 1.16 ± 0.08 and 1.20 ± 0.09 mmol Trolox eq./l; TOS level was 28.77 ± 33.33 and 19.95 ± 10.42 μmol H202/l; DHEA-S level was 203.79 ± 84.75 μg/dl and 249.36 ± 122.93 μg/dl in the CSCR group and in the control group, respectively. The plasma TAC and DHEA-S values were significantly lower in the CSCR group than in the control group (p = 0.027 and p = 0.046, respectively). There was no significant difference between the CSCR and the control groups in terms of age, gender, and TOS levels (p > 0.05).
  
  
  CONCLUSIONS
  We demonstrated that the levels of plasma DHEA-S and antioxidative parameters were reduced in CSCR. Our results suggest that the antioxidant defense system may be inadequate or corrupted in CSCR. Reduced DHEA-S level is one of the factors that trigger this insufficiency.
authors.affiliation: Faculty of Medicine, Department of Ophthalmology, Dicle University, Diyarbakir, Turkey, turkcufm@gmail.com.
authors.forename: Fatih Mehmet
authors.initials: FM
authors.lastname: Türkcü
authors.forename: Harun
authors.initials: H
authors.lastname: Yüksel
authors.forename: Hatice
authors.initials: H
authors.lastname: Yüksel
authors.forename: Alparslan
authors.initials: A
authors.lastname: Sahin
authors.forename: Yasin
authors.initials: Y
authors.lastname: Cinar
authors.forename: Abdullah Kürşat
authors.initials: AK
authors.lastname: Cingü
authors.forename: Muhammed
authors.initials: M
authors.lastname: Sahin
authors.forename: Ihsan
authors.initials: I
authors.lastname: Caça
mesh_terms: D000208:Acute Disease; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D056833:Central Serous Chorioretinopathy / Q000097:blood*; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D016877:Oxidants / Q000097:blood*
chemical_list: D000975:Antioxidants; D016877:Oxidants; D019314:Dehydroepiandrosterone Sulfate