title: Serum levels of angiopoietin-2 are associated with the growth of multiple myeloma.
abstract: Angiopoietins and their receptor, Tie-2, have crucial role in angiogenesis. We measured serum levels of angiopoietin-2 (Ang-2), soluble Tie-2, and factors of burden and prognosis in myeloma (LDH, CRP, beta-2 microglobulin, and interleukin-6) in 55 newly diagnosed patients, with 30 of them in plateau phase, in order to note correlations among them. Levels of Ang-2 were higher in patients in advanced stage of disease, decreased in plateau phase, and correlated with all other factors. Circulating Ang-2 in myeloma patients significantly correlated to factors of disease burden and prognosis, and therefore measuring its levels may be important for the valuation of the disease.
authors.affiliation: Hematology Department, Venizelion Hospital of Heraklion, Heraklion, Crete, Greece.
authors.forename: Constantina A
authors.initials: CA
authors.lastname: Pappa
authors.forename: George
authors.initials: G
authors.lastname: Tsirakis
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Samiotakis
authors.forename: Maria
authors.initials: M
authors.lastname: Tsigaridaki
authors.forename: Athanasios
authors.initials: A
authors.lastname: Alegakis
authors.forename: Nectaria
authors.initials: N
authors.lastname: Goulidaki
authors.forename: Michael G
authors.initials: MG
authors.lastname: Alexandrakis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D042702:Angiopoietin-2 / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000473:pathology*; D011379:Prognosis; D042787:Receptor, TIE-2 / Q000097:blood; D047368:Tumor Burden; D001613:beta 2-Microglobulin / Q000097:blood
chemical_list: D042702:Angiopoietin-2; D014408:Biomarkers, Tumor; C508600:IL6 protein, human; D015850:Interleukin-6; D001613:beta 2-Microglobulin; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase; D042787:Receptor, TIE-2