title: The canonical Wnt-beta-catenin pathway in development and chemotherapy of osteosarcoma.
abstract: The canonical Wnt-beta -catenin signaling pathway is a key component of normal skeletal development and disease. Alterations within this signaling pathway have been described in human and canine osteosarcoma (OS); however, debate exists as to whether or not alterations in this pathway contribute to OS development in humans. In metastatic OS, the Wnt-β-catenin pathway promotes the invasion and migration of OS cells and β-catenin acts as a biological marker of OS with the potential to metastasize to the lung. The participation of the Wnt-β-catenin pathway in OS development and metastasis is regulated by several factors, including hormones and alkaline phosphatase (ALP). This pathway is also involved in the resistance of OS to chemotherapy, especially in resistance to all three drugs used in standard chemotherapy, i.e. doxorubicin, cisplatin and methotrexate (MTX). In this review, we will summarize recent findings regarding the Wnt-β-catenin pathway in OS development and chemotherapy.
authors.affiliation: Jinling Hospital, Department of Orthopedics, Nanjing University, School of Medicine, Nanjing 210002, Peoples R China.
authors.forename: Chengjun
authors.initials: C
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Shi
authors.forename: Guangxin
authors.initials: G
authors.lastname: Zhou
authors.forename: Xiaozhou
authors.initials: X
authors.lastname: Liu
authors.forename: Sujia
authors.initials: S
authors.lastname: Wu
authors.forename: Jianning
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D051153:Wnt Proteins; D051176:beta Catenin