title: [Complete genome sequence characteristics of human echovirus 9 strain isolated in Yunnan, China].
abstract: To analyze the genomic sequence characteristics of a human Echovirus 9(ECHO-9) strain isolated from a child with Hand-foot-mouth disease (HFMD) in Kunming, Yunnan Province, in 2010. The complete genome sequence of a human echovirus 9 strain, MSH-KM812-2010 was determined. As other human enterovirus, its genome was 7,424 nucleotides (nts) in length and encoded for 2,203 amino acids (aas). In comparison to other human enteroviruses, MSH-KM812-2010 strain had the highest homology with other strains of human echovirus 9 in structural genomic regions and more homologous to other serotypes of B specie than to human echovirus 9 in non-structural genomic regions. Phylogenetic analysis based on complete VP1 gene revealed that the sequences of human echovirus 9 segregated into three distinct clades A, B and C with more than 15. 0% diversity between clades. All Chinese isolates belonged to the same clade. RDP3 and Blast revealed evident recombination in non-structural genomic regions. This report is the first to, describe the complete genome of the human echovirus 9 in China and provide an overview of the diversity of genetic characteristics of a circulating human echovirus 9.
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China. 13953842661@139.com
authors.forename: Yan-Ju
authors.initials: YJ
authors.lastname: Zhu
authors.forename: Yue
authors.initials: Y
authors.lastname: Pan
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Chen
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Liu
authors.forename: Hai-Jing
authors.initials: HJ
authors.lastname: Shi
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Liao
authors.forename: Qiang-Ming
authors.initials: QM
authors.lastname: Sun
authors.forename: Shao-Hui
authors.initials: SH
authors.lastname: Ma
mesh_terms: D001483:Base Sequence; D002681:China; D004459:Echovirus 9 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D005260:Female; D016679:Genome, Viral; D006801:Humans; D007223:Infant; D008969:Molecular Sequence Data; D010802:Phylogeny; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins