title: Biomimetic ion nanochannels as a highly selective sequential sensor for zinc ions followed by phosphate anions.
abstract: A novel biomimetic ion-responsive multi-nanochannel system is constructed by covalently immobilizing a metal-chelating ligand, 2,2'-dipicolylamine (DPA), in polyporous nanochannels prepared in a polymeric membrane. The DPA-modified multi-nanochannels show specific recognition of zinc ions over other common metal ions, and the zinc-ion-chelated nanochannels can be used as secondary sensors for HPO4(2-) anions. The immobilized DPA molecules act as specific-receptor binding sites for zinc ions, which leads to the highly selective zinc-ion response through monitoring of ionic current signatures. The chelated zinc ions can be used as secondary recognition elements for the capture of HPO4(2-) anions, thereby fabricating a sensing nanodevice for HPO4(2-) anions. The success of the DPA immobilization and ion-responsive events is confirmed by measurement of the X-ray photoelectron spectroscopy (XPS), contact angle (CA), and current-voltage (I-V) characteristics of the systems. The proposed nanochannel sensing devices display remarkable specificity, high sensitivity, and wide dynamic range. In addition, control experiments performed in complex matrices suggest that this sensing system has great potential applications in chemical sensing, biotechnology, and many other fields.
authors.affiliation: Department Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, P.R. China.
authors.forename: Cuiping
authors.initials: C
authors.lastname: Han
authors.forename: Haiyan
authors.initials: H
authors.lastname: Su
authors.forename: Zhongyue
authors.initials: Z
authors.lastname: Sun
authors.forename: Long
authors.initials: L
authors.lastname: Wen
authors.forename: Demei
authors.initials: D
authors.lastname: Tian
authors.forename: Kai
authors.initials: K
authors.lastname: Xu
authors.forename: Junfeng
authors.initials: J
authors.lastname: Hu
authors.forename: Aming
authors.initials: A
authors.lastname: Wang
authors.forename: Haibing
authors.initials: H
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
mesh_terms: D000588:Amines / Q000737:chemistry*; D000838:Anions; D040761:Biomimetic Materials / Q000737:chemistry*; D002413:Cations, Divalent; D002614:Chelating Agents / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D049329:Nanostructures; D010710:Phosphates / Q000032:analysis*; D010848:Picolinic Acids / Q000737:chemistry*; D011093:Polyethylene Terephthalates; D015032:Zinc / Q000032:analysis*
chemical_list: C501847:2,2'-dipicolylamine; D000588:Amines; D000838:Anions; D002413:Cations, Divalent; D002614:Chelating Agents; D056831:Coordination Complexes; D010710:Phosphates; D010848:Picolinic Acids; D011093:Polyethylene Terephthalates; D015032:Zinc
keywords: nanostructures; phosphate anions; sensors; zinc