title: [Phenotypic variability of Arabidopsis thaliana seedlings as a result of inhibition of Hsp90 chaperones].
abstract: The influence of geldanamycin (GDA)--an inhibitor of Hsp90 chaperones--on growth and morphogenesis of Arabidopsis thaliana seedlings was studied. It was shown that treatment of seeds Col with the inhibitor resulted in a dose-dependent increase in variability of seedling's rates of growth and phenotypes. GDA treatment of genetic polymorphic seeds of natural A. thaliana populations and UV-B irradiated seeds Col resulted in a significant rise in the amount of seedlings with morphological alterations and the amount of non-germinated seeds. The obtained data testify that Hsp90 may restrict stochastic processes, thereby participating in the plant development canalization, conceal genetic variations and maintain cell vitality.
authors.forename: L E
authors.initials: LE
authors.lastname: Kozeko
mesh_terms: D017360:Arabidopsis / Q000187:drug effects / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D016227:Benzoquinones / Q000494:pharmacology; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D047029:Lactams, Macrocyclic / Q000494:pharmacology; D010641:Phenotype; D036226:Seedlings / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D016227:Benzoquinones; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; C001277:geldanamycin