title: Primary orbital eosinophilic angiocentric fibrosis with intranasal extension.
abstract: BACKGROUND
  Eosinophilic angiocentric fibrosis is a chronic, idiopathic disorder that usually involves the upper respiratory tract and features progressive submucosal perivascular fibrosis of unknown etiology. To our knowledge, only 5 cases of eosinophilic angiocentric fibrosis with primary orbital involvement have been reported.
  
  
  RESULTS
  We report the case of a 46-year-old man with right proptosis and lateral globe displacement caused by a primary eosinophilic angiocentric fibrosis extending from the orbit into the anterior ethmoid. The nasal extension of the lesion helped in establishing the correct diagnosis.
  
  
  CONCLUSIONS
  Physicians involved in the treatment of orbital pathologies should be familiar with this entity, because it may manifest as an intraorbital mass growing primarily or secondly into the orbit. The clinical manifestations of eosinophilic angiocentric fibrosis with orbital involvement often mimic other more common ophthalmological diseases. Biopsies are necessary for diagnosis and treatment planning, although cures are usually of palliative effect.
authors.affiliation: Department of Otorhinolaryngology, University of Sassari, Sassari, Italy.
authors.forename: Apostolos
authors.initials: A
authors.lastname: Karligkiotis
authors.forename: Luca
authors.initials: L
authors.lastname: Volpi
authors.forename: Fabio
authors.initials: F
authors.lastname: Ferreli
authors.forename: Michele
authors.initials: M
authors.lastname: Cerati
authors.forename: Effrosyni
authors.initials: E
authors.lastname: Kagkelari
authors.forename: Francesco
authors.initials: F
authors.lastname: Meloni
authors.forename: Paolo
authors.initials: P
authors.lastname: Castelnuovo
mesh_terms: D001707:Biopsy, Needle; D004803:Eosinophilic Granuloma / Q000473:pathology* / Q000601:surgery; D005005:Ethmoid Sinus / Q000473:pathology; D005355:Fibrosis / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D015508:Nasal Obstruction / Q000175:diagnosis / Q000209:etiology; D009668:Nose Diseases / Q000473:pathology* / Q000601:surgery; D009916:Orbital Diseases / Q000473:pathology* / Q000628:therapy; D035583:Rare Diseases; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
keywords: endoscopic sinus surgery; eosinophilic angiocentric fibrosis; onion-skin pattern; orbit; sinonasal tract