title: Cabanillasin, a new antifungal metabolite, produced by entomopathogenic Xenorhabdus cabanillasii JM26.
abstract: Since the early 1980s, fungi have emerged as a major cause of human disease. Fungal infections are associated with high levels of morbidity and mortality, and are now recognized as an important public health problem. Gram-negative bacterial strains of genus Xenorhabdus are known to form symbiotic associations with soil-dwelling nematodes of the Steinernematidae family. We describe here the discovery of a new antifungal metabolite, cabanillasin, produced by Xenorhabdus cabanillasii. We purified this molecule by cation-exchange chromatography and reverse-phase chromatography. We then determined the chemical structure of cabanillasin by homo- and heteronuclear NMR and MS-MS. Cabanillasin was found to be active against yeasts and filamentous fungi involved in opportunistic infections.
authors.affiliation: Nosopharm, Nîmes, France.
authors.forename: Jessica
authors.initials: J
authors.lastname: Houard
authors.forename: André
authors.initials: A
authors.lastname: Aumelas
authors.forename: Thierry
authors.initials: T
authors.lastname: Noël
authors.forename: Sylvie
authors.initials: S
authors.lastname: Pages
authors.forename: Alain
authors.initials: A
authors.lastname: Givaudan
authors.forename: Valérie
authors.initials: V
authors.lastname: Fitton-Ouhabi
authors.forename: Philippe
authors.initials: P
authors.lastname: Villain-Guillot
authors.forename: Maxime
authors.initials: M
authors.lastname: Gualtieri
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002460:Cell Line / Q000187:drug effects; D003428:Cross Infection / Q000382:microbiology; D005658:Fungi / Q000145:classification / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology*; D009348:Nematoda / Q000382:microbiology; D009894:Opportunistic Infections / Q000382:microbiology*; D020593:Xenorhabdus / Q000145:classification* / Q000254:growth & development / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents