title: [Signification of Epstein-Barr virus detection in the cerebrospinal fluid of a patient with human immunodeficiency virus related Burkitt lymphoma].
abstract: The significance of Epstein-Barr virus detection in the cerebrospinal fluid of patients with Burkitt lymphoma is poorly studied. We report the case of a patient with immunodeficiency associated Burkitt lymphoma in complete remission who presented 5 months after the end of treatment, an isolated optic neuritis. Lumbar puncture found lymphocytic meningitis and the viral load of Epstein-Barr virus was 234,000 copies per milliliter in the cerebrospinal fluid. These symptoms could be explained by Epstein-Barr virus meningoencephalitis but the detection of MYC rearrangements in the cerebrospinal fluid confirms the diagnosis of Burkitt lymphoma cerebral relapse. The detection of the Epstein-Barr virus DNA in the cerebrospinal fluid should be interpreted with caution.
authors.affiliation: Service d'hématologie clinique, Hôpital militaire d'instruction Mohammed V, Rabat, Maroc. selimjennane@yahoo.com
authors.forename: Selim
authors.initials: S
authors.lastname: Jennane
authors.forename: El Mehdi
authors.initials: el M
authors.lastname: Mahtat
authors.forename: Johanna
authors.initials: J
authors.lastname: Konopacki
authors.forename: Vincent
authors.initials: V
authors.lastname: Foissaud
authors.forename: Bertrand
authors.initials: B
authors.lastname: Souleau
authors.forename: Jean Valère
authors.initials: JV
authors.lastname: Malfuson
authors.forename: Thierry
authors.initials: T
authors.lastname: De Revel
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000134:cerebrospinal fluid / Q000175:diagnosis; D000328:Adult; D001932:Brain Neoplasms / Q000556:secondary; D002051:Burkitt Lymphoma / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D020031:Epstein-Barr Virus Infections / Q000134:cerebrospinal fluid*; D015658:HIV Infections / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis; D015497:HIV-1 / Q000502:physiology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D011379:Prognosis
keywords: Burkitt lymphoma; Epstein-Barr virus; cerebrospinal fluid; human immunodeficiency virus