title: Glaucoma and CNS. Comparison of fMRI results in high tension and normal tension glaucoma.
abstract: OBJECTIVE
  The objective of our work was to determine whether there is a difference in fMRI activation between patients with high tension glaucoma (HTG) and those with normal tension glaucoma (NTG).
  
  
  METHODS
  The sample consisted of eight patients with different stages of high tension glaucoma (3 females aged 41-65 and 5 males aged 40-73 years) and eight patients, also with different stages of normal tension glaucoma (6 females aged 53-70 and 2 males aged 40-52 years). The control group consisted of eight healthy subjects (3 females aged 23-46 and 5 males aged 23-65 years). All underwent complete ophthalmological examination, including visual field, colour vision, and electrophysiological functions. The results were compared with fMRI images after stimulation with black/white (BW) and blue/yellow (BY) checkerboard and then statistically processed.
  
  
  RESULTS
  The authors analyzed the results of published studies on high tension versus normal tension glaucoma in the images obtained by fMRI. They concluded on the basis of electrophysiological examinations that in high tension glaucoma, damage of the whole visual pathway occurs, starting from retinal ganglion cells up to the visual cortex. In normal tension glaucoma the response of ganglion cells is relatively normal. The pathology is found mainly in the visual pathway. For this reason, the authors carried out fMRI examinations in high tension glaucoma patients and patients with normal tension glaucoma. They found that advancing stages of high tension glaucoma cause progression of fMRI activity decrease. These relations were not observed in normal tension glaucoma cases. Similarly, in high tension glaucoma on fMRI examination to yellow/blue stimuli, the fMRI activity decrease was found to be greater than that to black/white stimulation. No similar effect was observed in normal tension glaucoma.
  
  
  CONCLUSIONS
  Normal tension glaucoma is, from the etiopathogenetical view, a different disease than high tension glaucoma.
authors.affiliation: Eye department of the Clinic JL, V Hurkach 1296/10, Prague, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Lestak
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Tintera
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Svata
authors.forename: Lukas
authors.initials: L
authors.lastname: Ettler
authors.forename: Pavel
authors.initials: P
authors.lastname: Rozsival
mesh_terms: D000328:Adult; D000368:Aged; D055253:Color Vision; D005260:Female; D059907:Functional Neuroimaging; D005901:Glaucoma / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D014793:Visual Cortex; D014794:Visual Fields; D055815:Young Adult