title: Enzymatic AND logic gate with sigmoid response induced by photochemically controlled oxidation of the output.
abstract: We report a study of a system which involves an enzymatic cascade realizing an AND logic gate, with an added photochemical processing of the output, allowing the gate's response to be made sigmoid in both inputs. New functional forms are developed for quantifying the kinetics of such systems, specifically designed to model their response in terms of signal and information processing. These theoretical expressions are tested for the studied system, which also allows us to consider aspects of biochemical information processing such as noise transmission properties and control of timing of the chemical and physical steps.
authors.affiliation: Department of Physics, Clarkson University, Potsdam, New York 13676, USA.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Privman
authors.forename: Brian E
authors.initials: BE
authors.lastname: Fratto
authors.forename: Oleksandr
authors.initials: O
authors.lastname: Zavalov
authors.forename: Jan
authors.initials: J
authors.lastname: Halámek
authors.forename: Evgeny
authors.initials: E
authors.lastname: Katz
mesh_terms: D055162:Biocatalysis; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000737:chemistry / Q000378:metabolism; D006593:Hexokinase / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D008962:Models, Theoretical; D009243:NAD / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D004798:Enzymes; D009243:NAD; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase