title: Optical coherence tomography-assisted enhanced depth imaging of central serous chorioretinopathy.
abstract: OBJECTIVE
  To describe characteristics of central serous chorioretinopathy (CSC) imaged by optical coherence tomography-assisted enhanced depth imaging (EDI-OCT).
  
  
  METHODS
  The prospective observational case series study consisted of patients with acute or chronic CSC. All subjects underwent fundus fluorescein angiography, indocyanine green angiography (ICGA), and EDI-OCT.
  
  
  RESULTS
  The study included 68 eyes (68 patients) with 35 eyes showing signs of acute CSC. Mean subfoveal choroidal thickness, 478 ± 114 μm, was larger than the normative value from the beijing eye study 2011 (254 ± 107 μm) on the same ethnic group. In the hyperfluorescent ICGA areas, EDI-OCT revealed a thinning of the inner choroidal layers and enlargement of the underlying hyporeflective lumina in all eyes. the diameter of the hyporeflective lumina (mean: 330 ± 103 μm) was significantly (P < 0.001) associated with subfoveal choroidal thickness (correlation coefficient [r]: 0.68). An RPE detachment was detected in 36 (53%) eyes. A double-layer sign defined as an undulated RPE layer and intact underlying Bruch's membrane (seen in 51 [75%] eyes) was significantly (P = 0.025) more often in the chronic CSC group (29/33; 87%) than in the acute CSC group (22/35; 63%). Prevalence of an RPE microrip (8/68 [12%] eyes) did not differ (P = 0.14) between the chronic CSC group (6/33; 18%) and the acute CSC group (2/35; 5.7%).
  
  
  CONCLUSIONS
  CSC is characterized by a thinned inner choroidal layer and enlarged underlying hyporeflective choroidal lumina in all eyes, in addition to a dome-shaped RPE elevation, a double-layer sign of the RPE/Bruch's membrane complex, and RPE microrips in some eyes. EDI-OCT may be helpful in the diagnosis of CSC.
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Lab, Capital Medical University, Beijing, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Yang
authors.forename: Jost B
authors.initials: JB
authors.lastname: Jonas
authors.forename: Wenbin
authors.initials: W
authors.lastname: Wei
mesh_terms: D000208:Acute Disease; D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis*; D002681:China; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: OCT; central serous retinopathy; choroid; enhanced depth imaging; optical coherence tomography