title: Lack of Genetic Associations of PPAR-γ and PGC-1α with Alzheimer's Disease and Parkinson's Disease with Dementia.
abstract: OBJECTIVE
  Similar clinical and pathological features have been observed in Alzheimer's disease (AD) and Parkinson's disease with dementia (PDD). Both the peroxisome proliferator-activated receptor-γ (PPAR-γ) gene and the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) gene are candidates modifying the risk for both diseases. The aim of this study was to clarify whether common single nucleotide polymorphisms (SNPs) of the PPAR-γ gene and the PGC-1α gene affect the onset of AD and PDD genetically.
  
  
  METHODS
  Four exonic SNPs of both genes (rs1801282 and rs3856806 of the PPAR-γ gene, rs3736265 and rs8192678 of the PGC-1α gene) were genotyped in 171 AD patients, 136 age-matched controls and 53 PDD patients. Haplotype analysis and logistic regression analysis with apolipoprotein E (APO E) status were performed for AD.
  
  
  RESULTS
  There was no statistical difference between AD cases and controls for the 4 SNPs, nor was there any statistical difference between PDD cases and controls for the 4 SNPs. We could not find any synergetic associations between these SNPs, APO E4 and AD.
  
  
  CONCLUSIONS
  The 4 SNPs studied here did not influence the risk for AD in a Japanese population. As the number of PDD cases was small, comprehensive genetic studies considering diabetes would be needed.
authors.affiliation: Departments of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Nobuto
authors.initials: N
authors.lastname: Shibata
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Motoi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tomiyama
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohnuma
authors.forename: Bolati
authors.initials: B
authors.lastname: Kuerban
authors.forename: Katrin
authors.initials: K
authors.lastname: Tomson
authors.forename: Miwa
authors.initials: M
authors.lastname: Komatsu
authors.forename: Hiromi
authors.initials: H
authors.lastname: Shimazaki
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
authors.forename: Heii
authors.initials: H
authors.lastname: Arai
keywords: Alzheimer's disease; Apolipoprotein E; Dementia; PGC-1α; PPAR-γ; Parkinson's disease; Polymorphism