title: Modification of selected anti-HCMV drugs with lipophilic boron cluster modulator.
abstract: Methods for the modification of ganciclovir (GCV), acyclovir (ACV), cidofovir (CDV) and valganciclovir (VCDV) with boron cluster have been developed. Toxicity of the new derivatives was evaluated in adherent cells; no cytotoxicity was observed in five different cell lines up to 1000 microM with the exception of modified valganciclovir which was cytotoxic above 300 microM. The compounds were active against HCMV or HSV-1 by cytopathic effect or plaque reduction assays. None of the tested compounds had activity against HPIV-3 or VSV.
authors.affiliation: Institute of Medical Biology, Polish Academy of Sciences, Laboratory of Molecular Virology and Biological Chemistry, 106 Lodowa St., 93-232 Lódź, Poland.
authors.forename: Agnieszka B
authors.initials: AB
authors.lastname: Olejniczak
authors.forename: Anna M
authors.initials: AM
authors.lastname: Adamska
authors.forename: Edyta
authors.initials: E
authors.lastname: Paradowska
authors.forename: Mirosława
authors.initials: M
authors.lastname: Studzinska
authors.forename: Patrycja
authors.initials: P
authors.lastname: Suski
authors.forename: Zbigniew J
authors.initials: ZJ
authors.lastname: Leśnikowski
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001895:Boron; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects*; D004355:Drug Stability; D006801:Humans; D012995:Solubility; D013237:Stereoisomerism
chemical_list: D000998:Antiviral Agents; D001895:Boron