title: Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis.
abstract: Three new cembrane-type diterpenoids, flexibilins A-C (1-3), along with a known cembrane, (-)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1-4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.
authors.affiliation: Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors.forename: Li-Chung
authors.initials: LC
authors.lastname: Hu
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Michael Yen-Nan
authors.initials: MY
authors.lastname: Chiang
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Lu
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Yung-Husan
authors.initials: YH
authors.lastname: Chen
authors.forename: Wan-Ping
authors.initials: WP
authors.lastname: Hu
authors.forename: Nai-Cheng
authors.initials: NC
authors.lastname: Lin
authors.forename: Wei-Hsien
authors.initials: WH
authors.lastname: Wang
authors.forename: Lee-Shing
authors.initials: LS
authors.lastname: Fang
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010196:Pancreatic Elastase / Q000187:drug effects* / Q000378:metabolism; D013057:Spectrum Analysis; D013624:Taiwan; D014961:X-Ray Diffraction
chemical_list: D004224:Diterpenes; D010196:Pancreatic Elastase