title: Catalytic asymmetric aldol-type reaction of zinc enolate equivalent of amides.
abstract: Treatment of phenyl isocyanate with bis(iodozincio)methane gave a zinciomethylenated product, which acts as an amide-enoate equivalent. It did not react with an aldehyde efficiently, but gave the corresponding adduct in good yield in the presence of an aminoalcohol. Use of a catalytic amount of chiral aminoalcohol led the process to the catalytic asymmetric Aldol-type reaction.
authors.affiliation: Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyotodaigaku-katsura, Nishikyo, Kyoto 615-8510, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Haraguchi
authors.forename: Seijiro
authors.initials: S
authors.lastname: Matsubara