title: HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage.
abstract: Resveratrol is known to exert a cardioprotective effect against hypoxia/reoxygenation (H/R) injury. HS-1793 is a novel, more stable resveratrol analog, but its cardioprotective effects were unknown. The present study aimed to test the cardioprotective effect of HS-1793 against H/R injury and investigate the role of mitochondria in Sprague Dawley rat heart damage using an ex vivo Langendorff system. HS-1793 ameliorated H/R-induced mitochondrial dysfunction by reducing mitochondrial reactive oxygen species production, improving mitochondrial oxygen consumption and suppressing mitochondrial calcium (Ca(2+)) overload during reperfusion. Moreover, HS-1793-treated rat heart showed reduced infarct size. Our data suggest that HS-1793 can protect cardiac against mitochondrial damage following H/R, thereby suppressing injury.
authors.affiliation: National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633-165 Gaegeum-dong, Busanjin-gu, Busan 614 735, Republic of Korea.
authors.forename: Seung Hun
authors.initials: SH
authors.lastname: Jeong
authors.forename: Tran My
authors.initials: TM
authors.lastname: Hanh
authors.forename: Hyoung Kyu
authors.initials: HK
authors.lastname: Kim
authors.forename: Sung Ryul
authors.initials: SR
authors.lastname: Lee
authors.forename: In-Sung
authors.initials: IS
authors.lastname: Song
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Noh
authors.forename: Suhee
authors.initials: S
authors.lastname: Song
authors.forename: Hongsuk
authors.initials: H
authors.lastname: Suh
authors.forename: Nari
authors.initials: N
authors.lastname: Kim
authors.forename: Byoung Doo
authors.initials: BD
authors.lastname: Rhee
authors.forename: Kyung Soo
authors.initials: KS
authors.lastname: Ko
authors.forename: Jin
authors.initials: J
authors.lastname: Han
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D006321:Heart / Q000503:physiopathology; D000860:Hypoxia; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D009284:Naphthols / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D012118:Resorcinols / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry*
chemical_list: C523393:4-(6-hydroxy-2-naphthyl)-1,3-benzenediol; D009284:Naphthols; D017382:Reactive Oxygen Species; D012118:Resorcinols; D013267:Stilbenes; D000077185:Resveratrol; D002118:Calcium