title: Evaluation of the serum cystatin C values in prediction of indications for hemodialysis in patients with chronic renal failure.
abstract: BACKGROUND
  Indications of dialysis treatment for patients with end-stage renal disease depend on various clinical and laboratory parameters. In this study, we aimed to determine whether standardized serum cystatin C (SCC) equation may be an applicability of marker for dialysis initiation and its relationship to other clearance values among patients with advanced chronic kidney disease.
  
  
  METHODS
  A total of 84 patients (45 males, 39 females) aged 19-89 were evaluated in this study. Hemodialysis was indicated according to clinical and laboratory findings, and estimated glomerular filtration rate (eGFR) was according to four different formulas [MDRD, EpiCKD, Cockcroft Gault formula (CGF) and SCC equation].
  
  
  RESULTS
  eGFR values of patients in the study were 7.23 ± 3.26, 7.86 ± 3.78, 15.09 ± 10.88 and 11.31 ± 4.54 according to MDRD, EpiCKD, SCC equation and CGF, respectively. There was a positive correlation between MDRD, EpiCKD and CGF, and between EpiCKD and CGF (p < 0.01). Also, statistically significant correlation was found between SCC equation and CGF (p < 0.05).
  
  
  CONCLUSIONS
  SCC equation was not seemed to be an appropriate marker for starting dialysis in patients with advanced CKD.
authors.affiliation: Clinic of Internal Medicine/Nephrology, Bagcilar Training and Research Hospital, 34200, Bagcılar, Istanbul, Turkey, drdede75@hotmail.com.
authors.forename: Dede
authors.initials: D
authors.lastname: Sit
authors.forename: Taner
authors.initials: T
authors.lastname: Basturk
authors.forename: Süleyman
authors.initials: S
authors.lastname: Yildirim
authors.forename: Ferdi
authors.initials: F
authors.lastname: Karagoz
authors.forename: Nalan
authors.initials: N
authors.lastname: Bozkurt
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Gunes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D006435:Renal Dialysis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D055316:Cystatin C