title: Expanding the indication spectrum: renal denervation in diabetes.
abstract: Catheter-based renal denervation (RDN) has been shown to reduce sympathetic nerve activity and blood pressure in patients with resistant hypertension. Increased central sympathetic activity is a main contributor to the pathophysiology of several important chronic cardiovascular diseases, including diabetes and the metabolic syndrome. Indeed several recently published pilot studies and case reports suggest beneficial effects of RDN on glucose metabolism in patients with resistant hypertension. This review highlights the background of approaching the renal sympathetic nerves as a potential new therapeutic option to improve glycaemic control in patients with resistant hypertension.
authors.affiliation: Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany. felix.mahfoud@uks.eu
authors.forename: Felix
authors.initials: F
authors.lastname: Mahfoud
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ewen
authors.forename: Christian
authors.initials: C
authors.lastname: Ukena
authors.forename: Dominik
authors.initials: D
authors.lastname: Linz
authors.forename: Paul A
authors.initials: PA
authors.lastname: Sobotka
authors.forename: Bodo
authors.initials: B
authors.lastname: Cremers
authors.forename: Michael
authors.initials: M
authors.lastname: Böhm
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D017115:Catheter Ablation; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D004351:Drug Resistance; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D007668:Kidney / Q000294:innervation*; D013562:Sympathectomy / Q000379:methods*; D013564:Sympathetic Nervous System / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D001786:Blood Glucose