title: Sustained release solid lipid matrices processed by hot-melt extrusion (HME).
abstract: The aim of this work was to develop sustained release solid lipid matrices of diclofenac sodium (Df-Na) processed by hot melt extrusion (HME) and subsequent compression into tablets. Different extrusion processing approaches such as "cold", "hot" and pre-mixed formulations were used to develop the Compritol(®) 888 ATO lipid matrices by altering the extrusion temperatures, drug loading and formulation composition. The extrudates were characterized via a range of techniques such as differential scanning calorimetry (DSC), hot stage microscopy (HSM) and X-ray powder diffraction (XRPD) to identify the drug state within the lipid matrix. Df-Na was found to be either in crystalline or amorphous state depending on the processing conditions. Energy dispersive X-ray (EDX) microanalysis demonstrated excellent drug distribution of Df-Na on the surface of the compressed tablets. The lipid matrices developed by HME provided sustained release of pre-mixed formulations for 12h mainly controlled by diffusion.
authors.affiliation: University of Greenwich, School of Science, Chatham Maritime, Chatham, ME4 4TB Kent, UK.
authors.forename: K
authors.initials: K
authors.lastname: Vithani
authors.forename: M
authors.initials: M
authors.lastname: Maniruzzaman
authors.forename: I J
authors.initials: IJ
authors.lastname: Slipper
authors.forename: S
authors.initials: S
authors.lastname: Mostafa
authors.forename: C
authors.initials: C
authors.lastname: Miolane
authors.forename: Y
authors.initials: Y
authors.lastname: Cuppok
authors.forename: D
authors.initials: D
authors.lastname: Marchaud
authors.forename: D
authors.initials: D
authors.lastname: Douroumis
mesh_terms: D004008:Diclofenac / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties; D013607:Tablets / Q000737:chemistry; D044366:Transition Temperature
chemical_list: D005227:Fatty Acids; D008055:Lipids; D013607:Tablets; D004008:Diclofenac; C086409:glyceryl behenate