title: Surface-active agents from the group of polyoxyethylated glycerol esters of fatty acids. Part III. Surface activity and solubilizing properties of the products of oxyethylation of lard (Adeps suillus, F.P. VIII) in the equilibrium system in relation to lipophilic therapeutic agents (class II and III of BCS).
abstract: Research was conducted into the solubilization processes of diclofenac, ibuprofen, ketoprofen and naproxen in equilibrium conditions in the environment of aqueous solutions of oxyethylated lard's fractions (Adeps suillus, Polish Pharmacopoeia VIII). The determined thermodynamic (cmc, deltaGm(0)) and hydrodynamic (R0, R(obs), omega, M(eta)) parameters characterizing the micelle of the solubilizer and the adduct demonstrate that lipophilic therapeutic agents are adsorbed in a palisade structure of the micelle due to a topologically created so-called "lipophilic adsorption pocket". This shows that the hydrophilicity of the micelle and the adsorption layer decreases at the phase boundary, which is confirmed by the calculated values of coefficients A(m) and r x (a). The results obtained indicate the possibility of making use of the class of non-ionic surfactants which are not ksenobiotics for the modification of the profile of solid oral dosage forms with lipophilic therapeutic agents from the II class of Biopharmaceutics Classification System (BCS).
authors.affiliation: Department of Drug Form Technology, Chair of Applied Pharmacy, Faculty of Pharmacy, Medical University in Lodz, Muszyńskiego 1, 90-151 Łódź, Poland. michal.nachajski@umed.lodz.pl
authors.forename: Michał J
authors.initials: MJ
authors.lastname: Nachajski
authors.forename: Jowita B
authors.initials: JB
authors.lastname: Piotrowska
authors.forename: Michał K
authors.initials: MK
authors.lastname: Kołodziejczyk
authors.forename: Marek
authors.initials: M
authors.lastname: Lukosek
authors.forename: Marian M
authors.initials: MM
authors.lastname: Zgoda
mesh_terms: D000327:Adsorption; D004041:Dietary Fats; D005227:Fatty Acids / Q000737:chemistry*; D008823:Micelles; D012995:Solubility; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*; D013816:Thermodynamics; D014280:Triglycerides / Q000737:chemistry
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D008823:Micelles; D013501:Surface-Active Agents; D014280:Triglycerides; C029310:lard