title: Results of radical radiotherapy for squamous cell carcinoma of the eyelid.
abstract: OBJECTIVE
  To analyze the results of radical radiotherapy by electron beams for squamous cell carcinoma (SCC) of the eyelid and to find the possible prognostic factors.
  
  
  METHODS
  Records of 38 patients with histologically confirmed SCC of the eyelid who underwent electron beam radiation therapy between 1964 and 2010 in our institution were retrospectively reviewed. Median tumor size was 15 mm (range, 3-40 mm). T stage was T1 in three, T2a in six, T2b in 14, and T3a in 15 patients. Four patients had nodal metastasis. Of the 38 patients, 14 had relapsed disease after prior treatment. Median radiation dose was 60.0 Gy (range, 45.0-70.4 Gy). Median follow-up was 72.5 months (range, 2.0-369 months).
  
  
  RESULTS
  5-year local relapse-free, nodal relapse-free, distant metastasis-free and relapse-free rates for all patients were 71.8%, 77.5%, 90.6% and 58.0%, respectively. In seven patients, lymph node metastases occurred in 11 faciocervical regions. The 5-year overall survival was 79.5%. T stage and radiation dose expressed in EQD2 Gy tended to have impacts on local control. Relapsed patients showed unfavorable local relapse-free rate, however this was without statistical significance. Of the 14 patients who died, 12 succumbed to concurrent diseases. Grade 3 or greater severe late morbidities (CTCAE ver4.0) were observed in nine patients. Due to the morbidities, two patients lost their vision.
  
  
  CONCLUSIONS
  Radical radiotherapy for SCC of the eyelid yielded good results and could be a treatment option. Whether radiation-dose escalation could improve local control in advanced T stages and relapsed patients needs further study.
authors.affiliation: Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Inaba
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Suzuki
authors.forename: Shuhei
authors.initials: S
authors.lastname: Sekii
authors.forename: Kana
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Naoya
authors.initials: N
authors.lastname: Murakami
authors.forename: Madoka
authors.initials: M
authors.lastname: Morota
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mayahara
authors.forename: Minako
authors.initials: M
authors.lastname: Sumi
authors.forename: Takashi
authors.initials: T
authors.lastname: Uno
authors.forename: Jun
authors.initials: J
authors.lastname: Itami
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000532:radiotherapy*; D005142:Eyelid Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology*; D011882:Radiotherapy, High-Energy / Q000009:adverse effects* / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology*
keywords: electron therapy; eyelid SCC; radiotherapy