title: Effects of bioflavonoid ternatin on liver regeneration and oxidative stress in rats.
abstract: OBJECTIVE
  To evaluate the effect of bioflavonoid ternatin (TRT) on rat liver regeneration and oxidative stress after 70% partial hepatectomy (PH).
  
  
  METHODS
  Thirty six young male Wistar rats were randomly assigned to two groups of 18 animals each - control (G1) and experimental (G2) - and were submitted to PH under inhalatory diethylether anesthesia. G1 rats received daily intraperitoneal (ip) injections of saline (NaCl 0.9% solution) 0.1 mL/kg for 14 days; G2 animals received daily ip injections of TRT 0.1% 1.0mg/kg for 14 days. At 36h (T1), 168h (T2) and 336h (T3) post-PH timepoints, a subgroup of six rats in each group was chosen in a randomized way to complementary hepatectomy (CH) and blood samples haversting. Collected material was saved for laboratory analysis (total bilirubin (TB), D-Glucose, glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) and assessment of liver regeneration.
  
  
  RESULTS
  TRT induced a significant decrease in liver and plasma GSH concentrations; liver regeneration process was not affected. TRT promoted a significant decrease in blood glucose levels 168h after partial hepatectomy compared with controls. TB levels remained unchanged.
  
  
  CONCLUSIONS
  Intraperitoneal bioflavonoid ternatin injection in partially hepatectomized rats induces a decrease in oxidative stress and a significant hypoglycemic state, but does not promote any change in the evolution of liver regeneration.
authors.affiliation: Department of Surgery, UFC, Ceara, Brazil.
authors.forename: José Ulisses de Souza
authors.initials: JU
authors.lastname: Melo
authors.forename: Radamés Bezerra
authors.initials: RB
authors.lastname: Melo
authors.forename: Jefferson Menezes Viana
authors.initials: JM
authors.lastname: Santos
authors.forename: Manoel Messias
authors.initials: MM
authors.lastname: Campos Júnior
authors.forename: Sérgio Botelho
authors.initials: SB
authors.lastname: Guimarães
authors.forename: Paulo Roberto Leitão
authors.initials: PR
authors.lastname: Vasconcelos
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001663:Bilirubin / Q000097:blood; D005419:Flavonoids / Q000494:pharmacology*; D005947:Glucose / Q000032:analysis; D005978:Glutathione / Q000097:blood; D006498:Hepatectomy / Q000379:methods; D007274:Injections, Intraperitoneal; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009929:Organ Size; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D013997:Time Factors
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D017392:Thiobarbituric Acid Reactive Substances; C051080:ternatin (flavonoid); D005978:Glutathione; D005947:Glucose; D001663:Bilirubin