title: Fixing a hole where the Ras gets in.
abstract: A clinically efficacious Ras inhibitor has eluded drug-discovery efforts for decades. In a paper in Nature, Zimmermann and et al. show that blocking a hole in PDEδ that normally engages the lipid tail of Ras disrupts downstream signaling, pointing to a potentially promising route to develop Ras inhibitors for cancer treatment.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Iwig
authors.forename: John
authors.initials: J
authors.lastname: Kuriyan
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology*; D054707:Cyclic Nucleotide Phosphodiesterases, Type 6 / Q000378:metabolism*; D006801:Humans; D015689:Oncogene Protein p21(ras) / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D001562:Benzimidazoles; D054707:Cyclic Nucleotide Phosphodiesterases, Type 6; D015689:Oncogene Protein p21(ras)