title: Diagnostic value of bladder tumor fibronectin in patients with bladder tumor: a systematic review with meta-analysis.
abstract: OBJECTIVE
  Bladder tumor fibronectin (BTF) has been related as a promising biomarker for the early diagnosis of bladder tumor. The meta-analysis was used to establish the diagnostic value of bladder tumor fibronectin in diagnosing bladder tumor.
  
  
  METHODS
  Relevant literatures evaluating the value of BTF in the diagnosis of bladder tumor were searched in PubMed, Embase, China National Knowledge Infrastructure (CNKI), Technology of Chongqing (VIP), and Wan Fang Data. Summary estimates were used to evaluate the value of BTF in the diagnosis of bladder tumor by using the Meta-DiSc and STATA 11.0 statistical software.
  
  
  RESULTS
  The meta-analysis included 5 studies (649 patients, 291 controls). The summary estimates revealed that the pooled sensitivity was 81% (95% confidence interval [CI]: 74%-85.1%) and specificity was 80% (95%CI 74%-84%). In addition, the area under the summary ROC curve (AUC) was 0.86 (95%CI 0.82-0.89).
  
  
  CONCLUSIONS
  BTF is a potential marker for the diagnosis of bladder tumor, and more prospective studies are needed in the future.
authors.affiliation: Department of Pathogenic Biology, Chong Qing Medical University, China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Yang
authors.forename: Huang
authors.initials: H
authors.lastname: Huang
authors.forename: Zongyue
authors.initials: Z
authors.lastname: Zeng
authors.forename: Liuyang
authors.initials: L
authors.lastname: Zhao
authors.forename: Ping
authors.initials: P
authors.lastname: Hu
authors.forename: Dali
authors.initials: D
authors.lastname: He
authors.forename: Xi
authors.initials: X
authors.lastname: Tang
authors.forename: Zhaofang
authors.initials: Z
authors.lastname: Zeng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D016206:Databases, Bibliographic; D042241:Early Diagnosis; D005260:Female; D005353:Fibronectins / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012984:Software; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000652:urine*
chemical_list: D015415:Biomarkers; D005353:Fibronectins
keywords: AUC; BTF; Bladder tumor; Bladder tumor fibronectin; CI; DOR; Diagnosis; Meta-analysis; NLR; PLR; QUADAS; SROC; TUR; area under the summary ROC curve; bladder tumor fibronectin; confidence interval; diagnostic odds ratio; negative likelihood ratio; positive likelihood ratio; quality assessment of diagnostic accuracy studies; summary receiver operator characteristic; transurethral resection