title: A new survival score for patients with brain metastases from non-small cell lung cancer.
abstract: OBJECTIVE
  Non-small cell lung cancer (NSCLC) is the most common primary tumor in patients developing brain metastasis. This study was performed to develop and validate a survival score particularly for this group of patients.
  
  
  METHODS
  In this study, the data of 514 patients treated with whole-brain radiotherapy (WBRT) alone for brain metastasis from NSCLC were retrospectively analyzed. The patients were divided into a test group (n = 257) and a validation group (n = 257). In the multivariate analysis of the test group, gender, performance status, and extracranial metastases were independent predictors of survival and, therefore, included in the scoring system. The score for each of the three factors was obtained from the 6-month survival rate (in %) divided by 10. The total scores that represented the sum of the three scores were 5, 8, 9, 11, 12, or 15 points. Three prognostic groups were formed according to the total scores.
  
  
  RESULTS
  The 6-month survival rates in the test group were 9 % for 5-9 points (group A), 54 % for 11-12 points (group B), and 79 % for 15 points (group C). In the validation group the 6-month survival rates were 14, 56, and 78 %, respectively. The comparisons between the prognostic groups A, B, and C of the test and the validation group did not reveal any significant differences.
  
  
  CONCLUSIONS
  This new score appears valid and reproducible. It can help predict the survival of patients with brain metastasis from NSCLC.
authors.affiliation: Department of Radiation Oncology, University Hospital Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany. Rades.Dirk@gmx.net
authors.forename: D
authors.initials: D
authors.lastname: Rades
authors.forename: L
authors.initials: L
authors.lastname: Dziggel
authors.forename: B
authors.initials: B
authors.lastname: Segedin
authors.forename: I
authors.initials: I
authors.lastname: Oblak
authors.forename: V
authors.initials: V
authors.lastname: Nagy
authors.forename: A
authors.initials: A
authors.lastname: Marita
authors.forename: S E
authors.initials: SE
authors.lastname: Schild
authors.forename: N T
authors.initials: NT
authors.lastname: Trang
authors.forename: M T
authors.initials: MT
authors.lastname: Khoa
mesh_terms: D001932:Brain Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000556:secondary*; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality* / Q000532:radiotherapy / Q000556:secondary*; D015897:Comorbidity; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D020266:Radiotherapy, Conformal / Q000401:mortality*; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D015996:Survival Rate