title: High glucose modulates IL-6 mediated immune homeostasis through impeding neutrophil extracellular trap formation.
abstract: Neutrophils serve as an active constituent of innate immunity and are endowed with distinct ability for producing neutrophil extracellular traps (NETs) to eliminate pathogens. Earlier studies have demonstrated a dysfunction of the innate immune system in diabetic subjects leading to increased susceptibility to infections; however, the influence of hyperglycemic conditions on NETs is unknown. In the present study we demonstrate that (a) NETs are influenced by glucose homeostasis, (b) IL-6 is a potent inducer of energy dependent NET formation and (c) hyperglycemia mimics a state of constitutively active pro-inflammatory condition in neutrophils leading to reduced response to external stimuli making diabetic subjects susceptible to infections.
authors.affiliation: Department of Biotechnology, Manipal Life Sciences Center, Manipal University, Manipal, India.
authors.forename: Manjunath B
authors.initials: MB
authors.lastname: Joshi
authors.forename: Apurva
authors.initials: A
authors.lastname: Lad
authors.forename: Alevoor S
authors.initials: AS
authors.lastname: Bharath Prasad
authors.forename: Aswath
authors.initials: A
authors.lastname: Balakrishnan
authors.forename: Lingadakai
authors.initials: L
authors.lastname: Ramachandra
authors.forename: Kapaettu
authors.initials: K
authors.lastname: Satyamoorthy
mesh_terms: D002478:Cells, Cultured; D003847:Deoxyglucose / Q000494:pharmacology; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology / Q000378:metabolism; D005947:Glucose / Q000502:physiology*; D006019:Glycolysis; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D006943:Hyperglycemia / Q000276:immunology / Q000378:metabolism; D007113:Immunity, Innate; D015850:Interleukin-6 / Q000502:physiology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D050296:Microbial Viability; D018375:Neutrophil Activation; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D008070:Lipopolysaccharides; D003847:Deoxyglucose; D005947:Glucose; D013755:Tetradecanoylphorbol Acetate