title: Postweaning social isolation exacerbates neurotoxic effects of the NMDA receptor antagonist MK-801 in rats.
abstract: The glutamate hypothesis of schizophrenia postulates NMDA receptor hypofunction as important pathophysiological mechanism. In rodents, NMDA receptor antagonists induce together with psychosis-like effects cortical injury. Stress during adolescence can trigger schizophrenia by unknown mechanisms. Here we show in rats that juvenile chronic isolation significantly increases MK-801-triggered expression of heat shock protein 70, a marker of neuronal injury, in the retrosplenial cortex. These data suggest an additive effect of juvenile stress and NMDA receptor blockade, with possible relevance for schizophrenia.
authors.affiliation: Department of Psychiatry and Psychotherapy, RG Animal Models in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J 5, 68159, Mannheim, Germany, Dragos.Inta@zi-mannheim.de.
authors.forename: Dragos
authors.initials: D
authors.lastname: Inta
authors.forename: Peter
authors.initials: P
authors.lastname: Renz
authors.forename: Juan M
authors.initials: JM
authors.lastname: Lima-Ojeda
authors.forename: Christof
authors.initials: C
authors.lastname: Dormann
authors.forename: Peter
authors.initials: P
authors.lastname: Gass
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D016291:Dizocilpine Maleate / Q000633:toxicity*; D018691:Excitatory Amino Acid Antagonists / Q000633:toxicity*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009498:Neurotoxins / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012934:Social Isolation
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018840:HSP70 Heat-Shock Proteins; D009498:Neurotoxins; D016291:Dizocilpine Maleate