title: [Optimization and characterization of SalB-pC loaded self-emulsifying drug delivery system].
abstract: OBJECTIVE
  To prepare self-emulsifying delivery system (SEDDS) of Salvianolic acid B phospholipid complex (SalB-PC) and evaluate its quality.
  
  
  METHODS
  The best formulation was optimized using single-factor and pseudo-ternary phase diagrams, according to the emulsifying efficiency, the characteristics and partical size of the emulsion and other indicators. The morphology, particle size, zeta-potential and the release in artificial intestinal fluid of self-emulsifying formulation were evaluated.
  
  
  RESULTS
  The weight ratio of SalB-PC: Lauroglycol FCC:Cremophor EL:Transcutol P in the best formulation was 9:45:40:15. SalB-PC loaded self-emulsifying formulation is yellow and transparent solution, with partical size about (187.2 +/- 7.1) nm, polydispersity index (PDI) about 0.267 +/- 0.008 and zeta-potential about (-35.6 +/- 2.7) mV after diluted about 100-fold. The self-emulsifying formulation released slower than the solution with only SalB or SalB-PC.
  
  
  CONCLUSIONS
  Water-soluble drug Salvianolic acid B can be prepared to SEDDS, and this formulation can slow down the release of SalB in artificial intestinal fluid.
authors.affiliation: Key Laboratory of Drug Targeting and Novel Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Ting-De
authors.initials: TD
authors.lastname: Tong
authors.forename: Rui
authors.initials: R
authors.lastname: Huang
authors.forename: Xun
authors.initials: X
authors.lastname: Sun
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Gong
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Zhang
mesh_terms: D000284:Administration, Oral; D001572:Benzofurans / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000379:methods*; D045703:Emulsifying Agents / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry; D010743:Phospholipids / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D053630:Depsides
chemical_list: D001572:Benzofurans; D004337:Drug Carriers; D045703:Emulsifying Agents; D004655:Emulsions; D010743:Phospholipids; C076944:salvianolic acid B; D053630:Depsides