title: Effect of licorice flavonoid oil on cholesterol metabolism in high fat diet rats.
abstract: Dietary licorice fravonoid oil (LFO) significantly decreased hepatic cholesterol and plasma lipoprotein cholesterol levels in high-fat diet rats. It significantly suppressed hydroxymethylglutaryl-CoA synthase activity and increased cholesterol 7α-hydroxylase activity. The low density lipoprotein receptor mRNA level was significantly increased by LFO. These results suggest that dietary LFO improves cholesterol metabolism in obese animals.
authors.affiliation: Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe, Japan. honda@tiger.kobe-u.ac.jp
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Honda
authors.forename: Takaoki
authors.initials: T
authors.lastname: Saneyasu
authors.forename: Shin
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tominaga
authors.forename: Shinichi
authors.initials: S
authors.lastname: Yokota
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kamisoyama
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000096:biosynthesis; D004035:Diet Therapy; D059305:Diet, High-Fat; D005419:Flavonoids / Q000008:administration & dosage*; D005786:Gene Expression Regulation / Q000187:drug effects; D006035:Glycyrrhiza / Q000737:chemistry; D006904:Hydroxymethylglutaryl-CoA Synthase / Q000096:biosynthesis; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood* / Q000188:drug therapy; D010938:Plant Oils / Q000008:administration & dosage*; D051381:Rats
chemical_list: D005419:Flavonoids; D008074:Lipoproteins; D010938:Plant Oils; C030104:lipoprotein cholesterol; D002784:Cholesterol; D002790:Cholesterol 7-alpha-Hydroxylase; D006904:Hydroxymethylglutaryl-CoA Synthase