title: Lower mannose-binding lectin contributes to deleterious H1N1 2009 infection in children.
abstract: Mannose-binding lectin (MBL) has broad range of activity against viruses through the mechanisms of neutralization, opsonization, and complement activation. Prior studies have demonstrated that MBL inactivated the season's influenza virus. Due to the fact that children have no neutralizing antibody against H1N1 2009 virus, innate immunity may be crucial in the defense against influenza. Therefore, we studied whether MBL levels played a role in H1N1 2009 infection in children. In a prospective survey, we revealed that MBL levels in ICU influenza cases were significantly lower than in children with influenza from infection disease ward. MBL may be involved in innate immune responses to H1N1 2009 infection in children.
authors.affiliation: Xihu District Liuxia Street Community Health Center, Hangzhou, China.
authors.forename: Lailong
authors.initials: L
authors.lastname: Gao
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Shang
authors.forename: Chenmei
authors.initials: C
authors.lastname: Zhang
authors.forename: Meiqin
authors.initials: M
authors.lastname: Tong
authors.forename: Yinghu
authors.initials: Y
authors.lastname: Chen
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006760:Hospitalization; D006801:Humans; D007113:Immunity, Innate; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology* / Q000473:pathology / Q000821:virology; D007362:Intensive Care Units; D008168:Lung / Q000473:pathology / Q000821:virology; D008297:Male; D037601:Mannose-Binding Lectin / Q000276:immunology* / Q000378:metabolism; D011446:Prospective Studies
chemical_list: D037601:Mannose-Binding Lectin
keywords: Children; H1N1 2009; MBL