title: Structures of KOD and 9°N DNA polymerases complexed with primer template duplex.
abstract: Replicate it: Structures of KOD and 9°N DNA polymerases, two enzymes that are widely used to replicate DNA with highly modified nucleotides, were solved at high resolution in complex with primer/template duplex. The data elucidate substrate interaction of the two enzymes and pave the way for further optimisation of the enzymes and substrates.
authors.affiliation: Department of Chemistry, Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.
authors.forename: Konrad
authors.initials: K
authors.lastname: Bergen
authors.forename: Karin
authors.initials: K
authors.lastname: Betz
authors.forename: Wolfram
authors.initials: W
authors.lastname: Welte
authors.forename: Kay
authors.initials: K
authors.lastname: Diederichs
authors.forename: Andreas
authors.initials: A
authors.lastname: Marx
mesh_terms: D001665:Binding Sites; D017931:DNA Primers / Q000737:chemistry* / Q000378:metabolism; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry* / Q000378:metabolism; D017434:Protein Structure, Tertiary; D019712:Thermococcus / Q000201:enzymology
chemical_list: D017931:DNA Primers; D004259:DNA-Directed DNA Polymerase