title: Predictive factors for 1-year outcome of a cohort of patients with severe traumatic brain injury (TBI): results from the PariS-TBI study.
abstract: OBJECTIVE
  To assess outcome and predicting factors 1 year after a severe traumatic brain injury (TBI).
  
  
  METHODS
  Multi-centre prospective inception cohort study of patients aged 15 or older with a severe TBI in the Parisian area, France. Data were collected prospectively starting the day of injury. One-year evaluation included the relatives-rating of the Dysexecutive Questionnaire (DEX-R), the Glasgow Outcome Scale-Extended (GOSE) and employment. Univariate and multivariate tests were computed.
  
  
  RESULTS
  Among 257 survivors, 134 were included (mean age 36 years, 84% men). Good recovery concerned 19%, moderate disability 43% and severe disability 38%. Among patients employed pre-injury, 42% were working, 28% with no job change. DEX-R score was significantly associated with length of education only. Among initial severity measures, only the IMPACT prognostic score was significantly related to GOSE in univariate analyses, while measures relating to early evolution were more significant predictors. In multivariate analyses, independent predictors of GOSE were length of stay in intensive care (LOS), age and education. Independent predictors of employment were LOS and age.
  
  
  CONCLUSIONS
  Age, education and injury severity are independent predictors of global disability and return to work 1 year after a severe TBI.
authors.affiliation: Service de Médecine Physique et de Réadaptation, APHP Hôpital Raymond Poincaré, Garches, France.
authors.forename: C
authors.initials: C
authors.lastname: Jourdan
authors.forename: V
authors.initials: V
authors.lastname: Bosserelle
authors.forename: S
authors.initials: S
authors.lastname: Azerad
authors.forename: I
authors.initials: I
authors.lastname: Ghout
authors.forename: E
authors.initials: E
authors.lastname: Bayen
authors.forename: P
authors.initials: P
authors.lastname: Aegerter
authors.forename: J J
authors.initials: JJ
authors.lastname: Weiss
authors.forename: J
authors.initials: J
authors.lastname: Mateo
authors.forename: T
authors.initials: T
authors.lastname: Lescot
authors.forename: B
authors.initials: B
authors.lastname: Vigué
authors.forename: K
authors.initials: K
authors.lastname: Tazarourte
authors.forename: P
authors.initials: P
authors.lastname: Pradat-Diehl
authors.forename: P
authors.initials: P
authors.lastname: Azouvi
mesh_terms: D000328:Adult; D017668:Age of Onset; D001930:Brain Injuries / Q000453:epidemiology* / Q000503:physiopathology / Q000534:rehabilitation*; D006233:Persons with Disabilities / Q000534:rehabilitation / Q000706:statistics & numerical data*; D004522:Educational Status; D004651:Employment / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D023261:Glasgow Outcome Scale; D006801:Humans; D015601:Injury Severity Score; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020127:Recovery of Function; D062707:Return to Work / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome