title: [Cytotoxicity of PVC tubes sterilized in ethylene oxide after gamma radiation exposure].
abstract: Do materials sterilized using gamma rays become toxic when re-sterilized in ethylene oxide? This question guided the objective of this study, which was to investigate the potential cytotoxic effect of PVC sterilized by gamma radiation and re-sterilized with EO by the agar diffusion method in cell cultures. Nine PVC tubes were subjected to gamma radiation sterilization and were re-sterilized in EO. The tubes were divided into a total of 81 units of analysis that were tested so as to represent the internal and external surfaces and mass of each tube. It was concluded that the PVC materials sterilized in gamma radiation and re-sterilized in EO are not cytotoxic.
authors.affiliation: Universidade de SãoPaulo. Bolsista do Conselho Nacional de Desenvolvimento Científico e Tecnológico, São Paulo, SP, Brasil. rafaelqsouza@hotmail.com
authors.forename: Rafael Queiroz
authors.initials: RQ
authors.lastname: de Souza
authors.forename: Kazuko Uchikawa
authors.initials: KU
authors.lastname: Graziano
authors.forename: Tamiko Ichikawa
authors.initials: TI
authors.lastname: Ikeda
authors.forename: Cláudia Regina
authors.initials: CR
authors.lastname: Gonçalves
authors.forename: Aurea Silveira
authors.initials: AS
authors.lastname: Cruz
mesh_terms: D002478:Cells, Cultured; D003603:Cytotoxins / Q000633:toxicity*; D004202:Disinfectants / Q000009:adverse effects*; D005027:Ethylene Oxide / Q000009:adverse effects*; D005720:Gamma Rays; D011143:Polyvinyl Chloride / Q000528:radiation effects* / Q000633:toxicity*; D013242:Sterilization / Q000379:methods*
chemical_list: D003603:Cytotoxins; D004202:Disinfectants; D011143:Polyvinyl Chloride; D005027:Ethylene Oxide