title: Construction of a spirooxindole amide library through nitrile hydrozirconation-acylation-cyclization cascade.
abstract: A library of spirooxindoles containing varied elements of structural and stereochemical diversity has been constructed via a three step, one pot nitrile hydrozirconation-acylation-cyclization reaction sequence from common acyclic indole intermediates. The resulting library was evaluated for novelty through comparison with MLSMR and Maybridge compound collections.
authors.affiliation: Department of Chemistry, Chemical Methodologies and Library Development, and ‡Department of Pharmaceutical Sciences, School of Pharmacy, Computational Chemical Genomics Screening Center, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
authors.forename: Matthew G
authors.initials: MG
authors.lastname: LaPorte
authors.forename: Sammi
authors.initials: S
authors.lastname: Tsegay
authors.forename: Ki Bum
authors.initials: KB
authors.lastname: Hong
authors.forename: Chunliang
authors.initials: C
authors.lastname: Lu
authors.forename: Cheng
authors.initials: C
authors.lastname: Fang
authors.forename: Lirong
authors.initials: L
authors.lastname: Wang
authors.forename: Xiang-Qun
authors.initials: XQ
authors.lastname: Xie
authors.forename: Paul E
authors.initials: PE
authors.lastname: Floreancig
mesh_terms: D000215:Acylation; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015040:Zirconium / Q000737:chemistry*
chemical_list: D007211:Indoles; D009570:Nitriles; D013141:Spiro Compounds; C030374:indole; D015040:Zirconium