title: Inhibition of amyloid β aggregation by acteoside, a phenylethanoid glycoside.
abstract: We examined the effects of acteoside (1a), which was isolated from Orobanche minor, and its derivatives on the aggregation of a 42-mer amyloid β protein (Aβ42) in our search for anti-amyloidogenic compounds for Alzheimer's disease (AD) therapy. Acteoside (1a) strongly inhibited the aggregation of Aβ42 in a dose-dependent manner. The structure-activity relationship for acteoside (1a) and related compounds suggests the catechol moiety of phenylethanoid glycosides to be essential for this inhibitory activity.
authors.affiliation: Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan.
authors.forename: Manami
authors.initials: M
authors.lastname: Kurisu
authors.forename: Yusaku
authors.initials: Y
authors.lastname: Miyamae
authors.forename: Kazuma
authors.initials: K
authors.lastname: Murakami
authors.forename: Junkyu
authors.initials: J
authors.lastname: Han
authors.forename: Hiroko
authors.initials: H
authors.lastname: Isoda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Irie
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Shigemori
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D016229:Amyloid beta-Peptides / Q000187:drug effects / Q000378:metabolism*; D002396:Catechols / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D031672:Orobanche / Q000737:chemistry; D010446:Peptide Fragments / Q000737:chemistry; D010636:Phenols / Q000008:administration & dosage* / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D013329:Structure-Activity Relationship; D059808:Polyphenols
chemical_list: D016229:Amyloid beta-Peptides; D002396:Catechols; D005960:Glucosides; D010446:Peptide Fragments; D010636:Phenols; D010936:Plant Extracts; C058956:acteoside; D059808:Polyphenols; C034221:catechol