title: The effect of acetabular inclination on metal ion levels following metal-on-metal hip arthroplasty.
abstract: Acetabular inclination angles have been suggested as a principal determinant of circulating metal ion levels in metal-on-metal hip arthroplasties. We aimed to determine whether inclination angle correlates with ion levels in arthroplasties using the Articular Surface Replacement (ASR) system. Patients undergoing ASR arthroplasties had blood metal ion levels and radiograph analysis performed a mean of 3.2 years after surgery. Inclination angle showed only a weak correlation with cobalt (r=0.21) and chromium (r=0.15) levels. The correlation between inclination angle and cobalt levels was significant only with small femoral components, although it was still weak. Multiple regression showed a complex interaction of factors influencing ion levels but inclination angle accounted for little of this variation. We conclude that the acetabular inclination angle is not a meaningful determinant of metal ion levels in ASR arthroplasties.
authors.affiliation: Lourdes Orthopaedic Hospital, Kilcreene, Kilkenny, Republic of Ireland.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Emmanuel
authors.forename: Karen M
authors.initials: KM
authors.lastname: Bergin
authors.forename: Gabrielle E
authors.initials: GE
authors.lastname: Kelly
authors.forename: Gerald F
authors.initials: GF
authors.lastname: McCoy
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Wozniak
authors.forename: John F
authors.initials: JF
authors.lastname: Quinlan
mesh_terms: D000077:Acetabulum / Q000601:surgery*; D019644:Arthroplasty, Replacement, Hip; D002857:Chromium / Q000097:blood*; D003035:Cobalt / Q000097:blood*; D005260:Female; D006621:Hip Joint / Q000601:surgery*; D006622:Hip Prosthesis / Q000009:adverse effects; D006801:Humans; D007477:Ions / Q000097:blood; D007592:Joint Diseases / Q000097:blood* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D011475:Prosthesis Failure
chemical_list: D007477:Ions; D002857:Chromium; D003035:Cobalt
keywords: ASR; acetabular inclination; failure; metal ion levels; metal-on-metal