title: [Introduction of dinitrosyl iron complexes with thiol-containing ligands into animal organism by inhalation method].
abstract: The possibility of water-soluble dinitrosyl iron complexes (DNIC) with thiol-containing ligands introduction into lungs and other tissues of mice by free inhalation of little drops (2-3 microns diameter) of the solutions of these complexes was investigated. Little drops of 2-20 mM solutions of the complexes were obtained by using an inhalation apparatus (compressor nebulizer). A cloud of these little drops was then inhaled by animals in a closed chamber. A maximal amount of protein-bound DNICs formed in mouse lungs was 0.6 micromoles per kilogram of tissue weight. The amount of DNIC in lungs, liver and blood decreased to the undetected level within 2-3 hours after inhalation. No cytotoxic effect of DNIC formed in lungs on Mycobacterium tuberculosis was found in mice infected with these mycobacteria.
authors.forename: A F
authors.initials: AF
authors.lastname: Vanin
authors.forename: G N
authors.initials: GN
authors.lastname: Mozhokina
authors.forename: N A
authors.initials: NA
authors.lastname: Tkachev
authors.forename: V D
authors.initials: VD
authors.lastname: Mikoian
authors.forename: R R
authors.initials: RR
authors.lastname: Borodulin
authors.forename: N A
authors.initials: NA
authors.lastname: Elistratova
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D007501:Iron / Q000008:administration & dosage* / Q000097:blood; D008024:Ligands; D008099:Liver / Q000187:drug effects*; D008168:Lung / Q000187:drug effects*; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000472:pathogenicity; D009589:Nitrogen Oxides / Q000008:administration & dosage* / Q000097:blood; D013438:Sulfhydryl Compounds / Q000008:administration & dosage; D014867:Water
chemical_list: D008024:Ligands; D009589:Nitrogen Oxides; D013438:Sulfhydryl Compounds; D014867:Water; C073661:dinitrosyl iron complex; D007501:Iron