title: Ligations from tyrosine isopeptides via 12- to 19-membered cyclic transition states.
abstract: Efficient syntheses of O-acyl Tyr-peptides allow chemical long-range ligation (O-acyl to N-acyl transfer) via each of 12- to 19-membered cyclic transition states. The results represent the first examples of successful isopeptide ligations starting from O-acyl Tyr-peptides.
authors.affiliation: Center for Heterocyclic Compounds, University of Florida, Department of Chemistry, Gainesville, Florida 32611-7200, USA.
authors.forename: Vadim
authors.initials: V
authors.lastname: Popov
authors.forename: Siva S
authors.initials: SS
authors.lastname: Panda
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky
mesh_terms: D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D014443:Tyrosine / Q000737:chemistry*
chemical_list: D010455:Peptides; D014443:Tyrosine