title: Post-stroke apathy: an exploratory longitudinal study.
abstract: BACKGROUND
  Post-stroke apathy is a disturbance of motivation evidenced by low initiative, difficulties in starting, sustaining or finishing any goal-directed activity, low self-activation or self-initiated behavior and emotional indifference. Apathy is a common behavioral disturbance in stroke survivors. We aimed to analyze the relationship between post-stroke apathy at 1 year after stroke and (1) apathy in acute phase; (2) demographic, pre-stroke predisposing conditions (previous mild cognitive impairment, alcohol abuse, mood/anxiety disorder) and clinical features (stroke type and location, neurological symptoms); (3) post-stroke depression and post-stroke cognitive impairment, and (4) post-stroke functional outcome, quality of life and the perception of health.
  
  
  METHODS
  Consecutive stroke (infarct/intracerebral hemorrhage) patients without aphasia or consciousness disturbances were included in the acute phase of stroke and assessed at 1 year after stroke. We assessed apathy with the clinically rated version of the Apathy Evaluation Scale. We also assessed post-stroke depression (Montgomery Asberg Depression Rating Scale) and post-stroke cognitive impairment (attention, mental flexibility, verbal, motor and graphomotor initiative, and non-verbal and verbal abstract reasoning, and Mini-Mental State Examination), functional outcome (Barthel Index), quality of life and perception of health (EuroQol). Data were analyzed using bivariate associations (χ(2) and t test) and stepwise multivariate analysis.
  
  
  RESULTS
  We included 76 stroke patients [32.9% women, mean age 62.9 years (SD = 10.9) and a mean of 6.9 (SD = 4.3) years of education]. Apathy was present in 17 patients in the acute phase and in 18 (23.7%) patients at 1 year after stroke. At 1 year after stroke, 41% of the acute apathetic patients remained apathetic. Sixty-one percent of new cases of post-stroke apathy were detected. Post-stroke apathy was associated only with previous cognitive impairment, apathy in acute stroke, post-stroke cognitive impairment, verbal abstract reasoning and with worse Barthel Index scale scores. In the multivariate logistic regression model, verbal abstract reasoning (odds ratio, OR = 7.03) and apathy in acute stroke (OR = 3.8) were identified as independent factors for post-stroke apathy at 1 year. Apathetic patients did not report worse quality of life or health.
  
  
  CONCLUSIONS
  Apathy in acute stroke phase was a reliable indicator of post-stroke apathy. Apathy should be assessed in both phases. Verbal abstract reasoning impairment was also an independent factor for post-stroke apathy impairing patients' ability to reason about goal-directed activity. Even though apathetic patients had worse post-stroke functional outcome, they did not report losing quality of life or having worse health.
authors.affiliation: Institute of Molecular Medicine, Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal. laracaeiro@fm.ul.pt
authors.forename: Lara
authors.initials: L
authors.lastname: Caeiro
authors.forename: José M
authors.initials: JM
authors.lastname: Ferro
authors.forename: Teresa
authors.initials: T
authors.lastname: Pinho E Melo
authors.forename: Patrícia
authors.initials: P
authors.lastname: Canhão
authors.forename: M Luísa
authors.initials: ML
authors.lastname: Figueira
mesh_terms: D000368:Aged; D057565:Apathy / Q000502:physiology*; D002543:Cerebral Hemorrhage / Q000150:complications / Q000523:psychology*; D060825:Cognitive Dysfunction / Q000150:complications / Q000523:psychology; D003863:Depression / Q000150:complications / Q000523:psychology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011569:Psychiatric Status Rating Scales / Q000592:standards; D020521:Stroke / Q000150:complications / Q000523:psychology*