title: Blocking HIV-1 gp120 at the Phe43 cavity: if the extension fits….
abstract: The Phe43 cavity is a mysterious feature in crystallographic structures of HIV-1 gp120-CD4 complexes. In this issue of Structure, Acharya and colleagues provide structural explanations for the potent neutralization by CD4 mimetic miniproteins with chemical extensions that fit into this cavity.
authors.affiliation: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Barna
authors.initials: B
authors.lastname: Dey
authors.forename: Edward A
authors.initials: EA
authors.lastname: Berger
mesh_terms: D015704:CD4 Antigens / Q000276:immunology*; D015699:HIV Envelope Protein gp120 / Q000737:chemistry*; D015497:HIV-1 / Q000276:immunology*; D018716:Molecular Mimicry; D009500:Neutralization Tests
chemical_list: D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120