title: [United theory of aging].
abstract: In attempts to develop a means of life prolongation the humankind has created more than three hundred theories of the aging; each of them offers the original cause of aging. However, none of them has given practical result by now. The majority of the theories have now only historical interest. There are several different theories that are mainly under consideration currently. They are based on reliable, proven evidence: the free radical theory, the protein error theory, the replicative senescence theory, the theory of reparation weakening, the immunological theory, several versions of neuroendocrinal theories, and programmed aging theory. The theory presented here is based on conception that the life as the phenomenon represents many of the interconnected physical and chemical processes propelled by energy of the mitochondrial bioenergetical machine. Gradual degradation of all vital processes is caused by the programmed decrease in level of bioenergetics. This theory unites all existing theories of aging constructed on authentic facts: it is shown, that such fundamental phenomena accompanying aging process as the increase in level of reactive oxygen species (ROS), the decrease in the general level of protein synthesis, the limitation of cellular dividing (Haiflick limit), decrease in efficiency of reparation mechanisms are caused by bioenergetics attenuation. Each of these phenomena in turn generates a number of harmful secondary processes. Any of the theories bases on one of these destructive phenomena or their combination. Hence, each of them describes one of sides of process of the aging initially caused by programmed decrease of level of bioenergetics. This united theory gives the chance to understand the nature of aging clock and explains a phenomenon of increase in longevity at the condition of food restriction. Failures of attempts to develop means from aging are explained by that the manipulations with the separate secondary phenomena of attenuation of bioenergetics, now in use, are not capable to advance longevity beyond the bounds of its natural duration. There is only one way to achieve an unlimited healthy life--to find a way of bioenergetics management.
authors.forename: A G
authors.initials: AG
authors.lastname: Trubitsyn
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D004734:Energy Metabolism / Q000235:genetics / Q000502:physiology*; D005853:Geriatrics / Q000379:methods*; D006801:Humans; D008962:Models, Theoretical; D014176:Protein Biosynthesis / Q000235:genetics / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species