title: [Seizure outcomes of cerebral hemispherectomy in adults: A systematic review and individual patient data meta-analysis].
abstract: OBJECTIVE
  The objective of our study was to determine the seizure control rate of cerebral hemispherectomies in adult patients with drug-resistant epilepsy.
  
  
  METHODS
  A systematic review and individual patient data meta-analysis was carried out. Seven international databases and scientific meeting proceedings were reviewed. Individual patient data were analysed to establish potential factors associated with postoperative seizure control.
  
  
  RESULTS
  Eight articles that satisfied the pre-established selection criteria were identified. After a median follow-up of 70 months (interquartile range, 29-175.5), 79.4% of patients remained seizure-free. There were no statistically significant differences in age at onset of epilepsy, duration of epilepsy, age at surgery, time of follow-up, gender, surgical-laterality, aetiology and ictal EEG abnormalities between seizure-free patients and those with recurrences.
  
  
  CONCLUSIONS
  Cerebral hemispherectomy has a high seizure control rate in adult patients with drug-resistant epilepsy. None of the variables analysed in the present study were associated with surgical success.
authors.affiliation: Grupo de Investigación en Ciencias de la Salud y Neurociencias (CISNEURO), Cartagena de Indias, Colombia; Sección de Neurocirugía, Facultad de Medicina, Universidad de Cartagena, Cartagena de Indias, Colombia. Electronic address: cisneuro.investigacion@gmail.com.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Alcalá-Cerra
authors.forename: Angel
authors.initials: A
authors.lastname: Paternina-Caicedo
authors.forename: Cindy
authors.initials: C
authors.lastname: Díaz-Becerra
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Gutiérrez-Paternina
mesh_terms: D000328:Adult; D000367:Age Factors; D000927:Anticonvulsants / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004351:Drug Resistance; D004827:Epilepsy / Q000188:drug therapy / Q000601:surgery*; D005260:Female; D038421:Hemispherectomy / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D064887:Observational Studies as Topic; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants
keywords: Adult; Adulto; Cirugía de epilepsia; Crisis epilépticas; Epilepsia; Epilepsy; Epilepsy surgery; Functional hemispherotomy; Functional outcomes; Hemisferectomía; Hemisferectomía funcional; Hemispherectomy; Resultados funcionales; Seizures