title: Copper-catalyzed oxidative condensation of α-oxocarboxylic acids with formamides: synthesis of α-ketoamides.
abstract: A copper-catalyzed coupling of α-oxocarboxylic acids with formamides is reported. This simple method provides a practical approach toward the synthesis of α-ketoamides with a variety of functional groups. Mechanistic studies have shown that the reaction proceeded via a radical process and (13)C-labeled experiments proved that the amide carbon in the products comes from the corresponding carboxylic acid, not from the DMF.
authors.affiliation: Department of Chemistry, School of Science and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an 710049, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Guo
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Duan
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003300:Copper / Q000737:chemistry*; D005559:Formamides / Q000138:chemical synthesis* / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D002264:Carboxylic Acids; D005559:Formamides; D003300:Copper