title: Increases in the risk of cognitive impairment and alterations of cerebral β-amyloid metabolism in mouse model of heart failure.
abstract: Epidemiological and clinico-pathological studies indicate a causal relationship between heart disease and Alzheimer's disease (AD). To learn whether heart disease causes an onset of AD, mice with myocardial infarction (MI) and congestive heart failure (HF) were used to test neuropsychiatric and cognitive behaviors as well as for measurements of AD related protein markers. To this end, adult mice were subjected to ligation of left anterior descending artery (LAD) and about two weeks later high-frequency echocardiography was performed to exam the resulting cardiac structure and function. Three months after successful induction of chronic heart failure (CHF) these mice showed an impairment of learning in the Morris Water Maze task. In addition, the expression of selected molecules, which are involved in β-amyloid metabolism, apoptosis and inflammation on the level of gene transcription and translation, was altered in CHF mice. Our findings provide a plausible explanation that CHF increases the risk of cognitive impairments and alters cerebral β-amyloid metabolism. In addition, our data indicate that the cerebral compensatory mechanisms in response to CHF are brain area and gender specific.
authors.affiliation: State Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Hong
authors.forename: Liping
authors.initials: L
authors.lastname: Bu
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Yufang
authors.initials: Y
authors.lastname: Huang
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Haiyun
authors.initials: H
authors.lastname: Suo
authors.forename: Lumeng
authors.initials: L
authors.lastname: Yang
authors.forename: Yuncen
authors.initials: Y
authors.lastname: Shi
authors.forename: Yi
authors.initials: Y
authors.lastname: Lou
authors.forename: Zhengliang
authors.initials: Z
authors.lastname: Sun
authors.forename: Guoqi
authors.initials: G
authors.lastname: Zhu
authors.forename: Thomas
authors.initials: T
authors.lastname: Behnisch
authors.forename: Mei
authors.initials: M
authors.lastname: Yu
authors.forename: Jianguo
authors.initials: J
authors.lastname: Jia
authors.forename: Wangxi
authors.initials: W
authors.lastname: Hai
authors.forename: Hongping
authors.initials: H
authors.lastname: Meng
authors.forename: Sheng
authors.initials: S
authors.lastname: Liang
authors.forename: Fang
authors.initials: F
authors.lastname: Huang
authors.forename: Yunzeng
authors.initials: Y
authors.lastname: Zou
authors.forename: Junbo
authors.initials: J
authors.lastname: Ge
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001007:Anxiety / Q000150:complications; D017209:Apoptosis; D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D003071:Cognition; D004195:Disease Models, Animal; D005260:Female; D005947:Glucose / Q000378:metabolism; D006333:Heart Failure / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D007858:Learning; D008124:Locomotion; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D049268:Positron-Emission Tomography; D012306:Risk; D012727:Sex Characteristics; D014057:Tomography, X-Ray Computed; D014158:Transcription, Genetic
chemical_list: D016229:Amyloid beta-Peptides; D005947:Glucose