title: Early language profiles in infants at high-risk for autism spectrum disorders.
abstract: Many preschoolers with autism spectrum disorders (ASD) present relative lack of receptive advantage over concurrent expressive language. Such profile emergence was investigated longitudinally in 54 infants at high-risk (HR) for ASD and 50 low-risk controls, with three language measures taken across four visits (around 7, 14, 24, 38 months). HR infants presented three outcome subgroups: ASD, other atypicality, and typical development. Reduced receptive vocabulary advantage was observed in HR infants by 14 months, but was maintained to 24 months only in ASD/other atypicality outcome subgroups while typically-developing HR infants regained a more normative profile. Few group differences appeared on a direct assessment of language and parent-reported functional communication. Processes of early development toward ASD outcome and in intermediate phenotypes are discussed.
authors.affiliation: Olga Tennison Autism Research Centre, School of Psychological Science, La Trobe University, Melbourne, VIC, 3086, Australia, k.hudry@latrobe.edu.au.
authors.forename: Kristelle
authors.initials: K
authors.lastname: Hudry
authors.forename: Susie
authors.initials: S
authors.lastname: Chandler
authors.forename: Rachael
authors.initials: R
authors.lastname: Bedford
authors.forename: Greg
authors.initials: G
authors.lastname: Pasco
authors.forename: Teodora
authors.initials: T
authors.lastname: Gliga
authors.forename: Mayada
authors.initials: M
authors.lastname: Elsabbagh
authors.forename: Mark H
authors.initials: MH
authors.lastname: Johnson
authors.forename: Tony
authors.initials: T
authors.lastname: Charman
mesh_terms: D002659:Child Development Disorders, Pervasive / Q000453:epidemiology / Q000503:physiopathology*; D002663:Child Language; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007802:Language; D007805:Language Development Disorders / Q000503:physiopathology*; D008297:Male; D012306:Risk