title: Arbortristoside-A and 7-O-trans-cinnamoyl-6β-hydroxyloganin isolated from Nyctanthes arbortristis possess anti-ulcerogenic and ulcer-healing properties.
abstract: Nyctanthes arbortristis Linn (Oleaceae) is widely distributed in sub-Himalayan regions and southwards to Godavari, India commonly known as Harsingar and Night Jasmine. In continuation of our drug discovery program on Indian medicinal plants, we isolated arbortristoside-A (AT) and 7-O-trans-cinnamoyl-6β-hydroxyloganin (6-HL) from the seeds of N. arbortristis. AT and 6-HL exhibited anti ulcer activity in experimentally induced ulcer models including cold restraint stress (CRU), alcohol (AL), pylorus ligation-induced gastric ulcer (PL) models and they also showed ulcer healing effect in chronic acetic acid-induced ulcer model (AC).
authors.affiliation: Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226001, UP, India.
authors.forename: Vaibhav
authors.initials: V
authors.lastname: Mishra
authors.forename: Astha
authors.initials: A
authors.lastname: Shukla
authors.forename: Sukanya
authors.initials: S
authors.lastname: Pandeti
authors.forename: Manoj Kumar
authors.initials: MK
authors.lastname: Barthwal
authors.forename: Haushila Prasad
authors.initials: HP
authors.lastname: Pandey
authors.forename: Gautam
authors.initials: G
authors.lastname: Palit
authors.forename: Tadigoppula
authors.initials: T
authors.lastname: Narender
mesh_terms: D019342:Acetic Acid / Q000494:pharmacology; D000438:Alcohols / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D057888:Iridoid Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029592:Oleaceae / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D054328:Proton Pump Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011708:Pylorus; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013312:Stress, Physiological
chemical_list: C586936:7-O-trans-cinnamoyl-6beta-hydroxyloganin; D000438:Alcohols; D000897:Anti-Ulcer Agents; D002934:Cinnamates; D057888:Iridoid Glucosides; D039823:Iridoids; D010936:Plant Extracts; D054328:Proton Pump Inhibitors; C528442:arbortristoside A; D019342:Acetic Acid
keywords: 7-O-Trans-cinnamoyl6β-hydroxyloganin; Arbortristoside-A; Gastric ulcer; Nyctanthes arbortristis; PGE2; Proton pump