title: Deterioration in donepezil-induced PR prolongation after a coadministration of memantine in a patient with Alzheimer's disease.
abstract: The side effects and interaction of memantine and donepezil hydrochloride when used concomitantly are currently unknown. We encountered a case of a 77-year-old female with Alzheimer's disease in which the concomitant use of memantine exacerbated the prolonged electrocardiogram PR interval which appeared while donepezil hydrochloride was being orally administered. In terms of the cardiac circulation system side effects caused by donepezil hydrochloride and memantine, bradycardia has been reported. However, clinicians should be also aware of PR prolongation associated with the concomitant use of donepezil and memantine.
authors.affiliation: Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Igeta
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Takaharu
authors.initials: T
authors.lastname: Motegi
authors.forename: Aiko
authors.initials: A
authors.lastname: Sasaki
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Someya
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D054537:Atrioventricular Block / Q000139:chemically induced*; D001919:Bradycardia / Q000139:chemically induced*; D000077265:Donepezil; D015259:Dopamine Agents / Q000009:adverse effects*; D004347:Drug Interactions; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007189:Indans / Q000009:adverse effects*; D008559:Memantine / Q000009:adverse effects*; D018697:Nootropic Agents / Q000009:adverse effects*; D010880:Piperidines / Q000009:adverse effects*
chemical_list: D015259:Dopamine Agents; D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil; D008559:Memantine
keywords: Alzheimer's disease; Donepezil; Memantine; PR prolongation