title: Increased glyoxalase-1 levels in Fkbp5 knockout mice caused by glyoxalase-1 gene duplication.
abstract: Fkbp5 is genetically linked to stress-related diseases. Fkbp5 knockout mice are available and widely used to explore the role of Fkbp5 in health and disease. We found that these mice carry a gene duplication of glyoxylase-1, which explains why glyoxylase-1 levels are increased in the Fkbp5 knockout mice.
authors.affiliation: Max Planck Institute of Psychiatry, 80804 Munich, Germany.
authors.forename: Lorenz K
authors.initials: LK
authors.lastname: Kollmannsberger
authors.forename: Nils C
authors.initials: NC
authors.lastname: Gassen
authors.forename: Andrea
authors.initials: A
authors.lastname: Bultmann
authors.forename: Jakob
authors.initials: J
authors.lastname: Hartmann
authors.forename: Peter
authors.initials: P
authors.lastname: Weber
authors.forename: Mathias V
authors.initials: MV
authors.lastname: Schmidt
authors.forename: Theo
authors.initials: T
authors.lastname: Rein
mesh_terms: D000818:Animals; D020440:Gene Duplication; D057809:HEK293 Cells; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D022021:Tacrolimus Binding Proteins / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism; D000099159:Tacrolimus Binding Protein 5
chemical_list: D007791:Lactoylglutathione Lyase; D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5
keywords: FKBP51; flanking gene problem; glyoxalase-1; knockout mice