title: Association between angiotensin-converting enzyme I/D polymorphism and sepsis: A meta-analysis.
abstract: BACKGROUND
  Previous studies investigating the association between the angiotensin-converting enzyme I/D polymorphism and sepsis have provided inconsistent results. Thus, a meta-analysis was performed to clarify the effect of the angiotensin-converting enzyme I/D polymorphism on sepsis risk and sepsis-related mortality.
  
  
  METHODS
  A comprehensive literature search was performed. Six case-control studies and two cohort studies were included in this meta-analysis. Odds ratios and corresponding 95% confidence intervals were estimated using random-effects models.
  
  
  RESULTS
  Pooled analysis of six case-control studies showed that there was a significant association between the angiotensin-converting enzyme I/D polymorphism and sepsis risk in a recessive genetic model (odds ratio = 0.75, 95% confidence interval 0.62-0.91, p = 0.004). However, no significant association between the angiotensin-converting enzyme I/D polymorphism and mortality was observed (odds ratio = 0.84, 95% confidence interval 0.57-1.24, p = 0.38).
  
  
  CONCLUSIONS
  Our meta-analysis confirmed that the angiotensin-converting enzyme I/D polymorphism was associated with sepsis risk. However, the angiotensin-converting enzyme I/D polymorphism was not associated with sepsis mortality.
authors.affiliation: Department of General Surgery, The First People's Hospital of Jingzhou, Jingzhou, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Nephrology, The First People's Hospital of Jingzhou, Jingzhou, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Disease, Shanghai Changzheng Hospital, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Nie
authors.affiliation: Department of General Surgery, The First People's Hospital of Jingzhou, Jingzhou, China.
authors.forename: Shunjuan
authors.initials: S
authors.lastname: Tang
authors.affiliation: Department of General Surgery, The First People's Hospital of Jingzhou, Jingzhou, China.
authors.forename: Jiuyan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of General Surgery, The First People's Hospital of Jingzhou, Jingzhou, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, The First People's Hospital of Jingzhou, Jingzhou, China.
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Wan
authors.affiliation: Department of General Surgery, The First People's Hospital of Jingzhou, Jingzhou, China.
authors.forename: Botao
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, The First People's Hospital of Jingzhou, Jingzhou, China tgsjz@hotmail.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Song
mesh_terms: D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors; D018805:Sepsis / Q000201:enzymology* / Q000235:genetics* / Q000401:mortality
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Angiotensin-converting enzyme; association study; mortality; polymorphism; sepsis