title: Antimüllerian hormone as predictor of reproductive outcome in subfertile women with elevated basal follicle-stimulating hormone levels: a follow-up study.
abstract: OBJECTIVE
  To investigate the role of serum antimüllerian hormone (AMH) as a predictor of live birth and reproductive stage in subfertile women with elevated basal FSH levels.
  
  
  METHODS
  A prospective observational cohort study conducted between February 2005 and June 2009.
  
  
  METHODS
  Tertiary fertility center.
  
  
  METHODS
  Subfertile women with [1] a regular menstrual cycle (mean cycle length 25-35 days); [2] basal FSH concentrations ≥12.3 IU/L; and [3] younger than 40 years (n = 96).
  
  
  METHODS
  None.
  
  
  METHODS
  Live birth and reproductive stage according to the Stages of Reproductive Aging Workshop.
  
  
  RESULTS
  A cumulative live birth rate of 63.5% was observed during a median follow-up of 3.3 years (n = 85). The AMH level was significantly associated with live birth. There was evidence of a nonlinear prediction pattern, with an increase in chances of live birth until an AMH level of 1 μg/L. Other ovarian reserve tests and chronological age appeared of limited value in predicting live birth. In addition, AMH was significantly associated with the timing of reproductive stages (n = 68) (i.e., the occurrence of menopausal transition or menopause during follow-up).
  
  
  CONCLUSIONS
  The present findings suggest applicability of AMH determination as a marker for actual fertility in subfertile women with elevated basal FSH levels.
authors.affiliation: Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, The Netherlands. F.Yarde@umcutrecht.nl
authors.forename: Felicia
authors.initials: F
authors.lastname: Yarde
authors.forename: Marlies
authors.initials: M
authors.lastname: Voorhuis
authors.forename: Madeleine
authors.initials: M
authors.lastname: Dólleman
authors.forename: Erik A H
authors.initials: EA
authors.lastname: Knauff
authors.forename: Marinus J C
authors.initials: MJ
authors.lastname: Eijkemans
authors.forename: Frank J M
authors.initials: FJ
authors.lastname: Broekmans
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000032:analysis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007246:Infertility / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D008597:Menstrual Cycle / Q000097:blood; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D018873:Pregnancy Rate; D011379:Prognosis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone
keywords: Subfertility; antimüllerian hormone; elevated basal FSH; live birth; prediction