title: Synthesis of functionalized pseudopeptides through five-component sequential Ugi/nucleophilic reaction of N-substituted 2-alkynamides with hydrazides.
abstract: Five-component sequential Ugi/nucleophilic addition reaction of aromatic aldehydes, primary amines, propiolic acid, isocyanides, and hydrazides has been developed in order to access polyfunctional pseudopeptides. The reaction may proceed through formation of N-substituted 2-alkynamides as intermediates. This process is found to be mild and operationally simple with broad substrate scope.
authors.affiliation: Peptide Chemistry Research Center, K. N. Toosi University of Technology, P.O. Box 15875-4416 Tehran, Iran.
authors.forename: Shokoofeh
authors.initials: S
authors.lastname: Maghari
authors.forename: Sorour
authors.initials: S
authors.lastname: Ramezanpour
authors.forename: Saeed
authors.initials: S
authors.lastname: Balalaie
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Darvish
authors.forename: Frank
authors.initials: F
authors.lastname: Rominger
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Bijanzadeh
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D011422:Propionates / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000480:Alkynes; D000577:Amides; D000588:Amines; D003486:Cyanides; D006834:Hydrazines; D010455:Peptides; D011422:Propionates; C011537:propiolic acid