title: Ventilator-associated pneumonia caused by OXA-48-producing Escherichia coli complicated by ciprofloxacin-associated rhabdomyolysis.
abstract: We report the emergence of OXA-48 carbapenemase-producing Escherichia coli in Austria causing ventilator-associated pneumonia in a traveler returning from Egypt. Depending on resistance testing, quinolones may remain a therapeutic option for infections caused by these multiple resistant pathogens, as this class of drugs has a favorable safety and tolerability profile when compared to the alternatives. In this patient, however, the clinical course was dramatically complicated by the development of ciprofloxacin-associated rhabdomyolysis.
authors.affiliation: Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Andrea J
authors.initials: AJ
authors.lastname: Grisold
authors.forename: Martin
authors.initials: M
authors.lastname: Hoenigl
authors.forename: Ismar
authors.initials: I
authors.lastname: Ovcina
authors.forename: Thomas
authors.initials: T
authors.lastname: Valentin
authors.forename: Sonja
authors.initials: S
authors.lastname: Fruhwald
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D004926:Escherichia coli / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000209:etiology* / Q000382:microbiology; D029968:Escherichia coli Proteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D053717:Pneumonia, Ventilator-Associated / Q000382:microbiology*; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000382:microbiology*; D001618:beta-Lactamases
chemical_list: D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; D002939:Ciprofloxacin; D001618:beta-Lactamases