title: Peanut-skin polyphenols, procyanidin A1 and epicatechin-(4 β → 6)-epicatechin-(2 β → O → 7, 4 β → 8)-catechin, exert cholesterol micelle-degrading activity in vitro.
abstract: We identified epicatechin-(4 β → 6)-epicatechin-(2 β → O → 7, 4 β → 8)-catechin (EEC) in the skin of the peanut (Arachis hypogaea L.). EEC (a trimer) showed more potent cholesterol micelle-degrading activity than procyanidin A1 (a dimer) did in vitro. The hypercholesterolemia suppressing effect of a peanut skin polyphenol on rats fed high-cholesterol diet in our preceding experiments might thus have been due primarily to a micelle degrading effect in the intestine.
authors.affiliation: Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tamura
authors.forename: Naoko
authors.initials: N
authors.lastname: Inoue
authors.forename: Megumi
authors.initials: M
authors.lastname: Ozawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Shimizu-Ibuka
authors.forename: Soichi
authors.initials: S
authors.lastname: Arai
authors.forename: Naoki
authors.initials: N
authors.lastname: Abe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koshino
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Mura
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage; D010367:Arachis / Q000737:chemistry*; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002784:Cholesterol / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008823:Micelles; D059808:Polyphenols / Q000008:administration & dosage; D044945:Proanthocyanidins / Q000008:administration & dosage; D051381:Rats
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D008823:Micelles; D059808:Polyphenols; D044945:Proanthocyanidins; C457101:epicatechin-(4beta-8)-epicatechin-(4beta-8,2beta-O-7)-epicatechin-(4beta-8)-epicatechin; C520684:procyanidin A1; D002392:Catechin; D002784:Cholesterol