title: Myeloid derived suppressor cells: Targets for therapy.
abstract: The goal of achieving measurable response with cancer immunotherapy requires counteracting the immunosuppressive characteristics of tumors. One of the mechanisms that tumors utilize to escape immunosurveillance is the activation of myeloid derived suppressor cells (MDSCs). Upon activation by tumor-derived signals, MDSCs inhibit the ability of the host to mount an anti-tumor immune response via their capacity to suppress both the innate and adaptive immune systems. Despite their relatively recent discovery and characterization, anti-MDSC agents have been identified, which may improve immunotherapy efficacy.
authors.affiliation: Gastroenterology Division; Department of Medicine; University of Pennsylvania; Philadelphia, PA USA ; Abramson Cancer Center; University of Pennsylvania; Philadelphia, PA USA;
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Waldron
authors.forename: Jon G
authors.initials: JG
authors.lastname: Quatromoni
authors.forename: Tatiana A
authors.initials: TA
authors.lastname: Karakasheva
authors.forename: Sunil
authors.initials: S
authors.lastname: Singhal
authors.forename: Anil K
authors.initials: AK
authors.lastname: Rustgi
keywords: CpG oligodeoxynucleotides (ODN); Myeloid derived suppressor cells; RNA aptamer; curcumin; cyclophosphamide; docetaxol; gemcitabine