title: Serum 25-hydroxyvitamin D level is associated with aortic distensibility and left ventricle hypertrophy in newly diagnosed type 2 diabetes mellitus.
abstract: We aimed to evaluate the association between serum vitamin D status and elastic properties of aorta in patients with diabetes mellitus (DM). We studied 136 patients with newly diagnosed DM (mean age: 62.9 ± 10.6 years). Serum 25-hydroxyvitamin D was measured using a direct competitive chemiluminescent immunoassay. Aortic distensibility was calculated from the echocardiographically derived ascending aorta diameters and haemodynamic pressure measurements. Left ventricle mass index (LVMI) was determined according to the Devereux formula. Multiple linear regression analysis showed that vitamin D level is independently associated with LVMI (β = -0.259, p = 0.001), aortic distensibility (β = 0.369, p < 0.001), high-sensitive C-reactive protein (hs-CRP) (β = -0.220, p = 0.002) and body mass index (β = -0.167, p = 0.015) in patients with DM. In diabetic patients, serum 25-hydroxyvitamin D level is independently associated with aortic distensibility. Vitamin D may play a role on pathogenesis of impaired elastic properties of aorta in type 2 DM.
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Kuloğlu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Taner
authors.initials: T
authors.lastname: Şeker
authors.forename: Gülhan Yüksel
authors.initials: GY
authors.lastname: Kalkan
authors.forename: Sinan
authors.initials: S
authors.lastname: Kırım
authors.forename: Durmuş Y
authors.initials: DY
authors.lastname: Şahin
authors.forename: Hazar
authors.initials: H
authors.lastname: Harbalıoğlu
authors.forename: Caner
authors.initials: C
authors.lastname: Türkoglu
authors.forename: Armağan
authors.initials: A
authors.lastname: Acele
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Betül
authors.initials: B
authors.lastname: Özaltun
authors.forename: Murat
authors.initials: M
authors.lastname: Çaylı
mesh_terms: D000368:Aged; D001011:Aorta / Q000000981:diagnostic imaging / Q000503:physiopathology*; D062186:Arterial Pressure; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D004548:Elasticity; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D014463:Ultrasonography; D059289:Vascular Stiffness; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Diabetes; aortic distensibility; hypertrophy; inflammation; vitamin D