title: High-density lipoproteins delivering interleukin-15.
abstract: Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this chimera can be further enhanced by creating triple fusions with IL-15 receptor α domain involved in IL-15 trans-presentation.
authors.affiliation: Division of Hepatology and Gene Therapy; Center for Applied Medical Research, and University Clinic; University of Navarra, Pamplona; Navarra, Spain.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Ochoa
authors.forename: Ignacio
authors.initials: I
authors.lastname: Melero
authors.forename: Pedro
authors.initials: P
authors.lastname: Berraondo
keywords: Sushi domain; apolipoprotein AI; high-density lipoprotein; interleukin 15