title: Pharmacokinetics of caspofungin in critically ill patients on continuous renal replacement therapy.
abstract: Caspofungin pharmacokinetics was assessed in 27 critically ill patients, including 7 on continuous venovenous hemofiltration (CVVH), 8 on continuous venovenous hemodialysis (CVVHD), and 13 not requiring continuous renal replacement therapy (CRRT). Caspofungin exposure during CRRT was very similar to that of the control group and comparable to that in healthy volunteers. Caspofungin clearance by CRRT was very low. Therefore, the standard dosage of caspofungin is probably adequate for critically ill patients undergoing CVVH or CVVHD.
authors.affiliation: Clinical Pharmacokinetics Unit, Inflammation Research Laboratory, Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Weiler
authors.forename: Christoph
authors.initials: C
authors.lastname: Seger
authors.forename: Hartwig
authors.initials: H
authors.lastname: Pfisterer
authors.forename: Eva
authors.initials: E
authors.lastname: Stienecke
authors.forename: Florian
authors.initials: F
authors.lastname: Stippler
authors.forename: René
authors.initials: R
authors.lastname: Welte
authors.forename: Michael
authors.initials: M
authors.lastname: Joannidis
authors.forename: Andrea
authors.initials: A
authors.lastname: Griesmacher
authors.forename: Romuald
authors.initials: R
authors.lastname: Bellmann
mesh_terms: D016022:Case-Control Studies; D000077336:Caspofungin; D016638:Critical Illness; D004341:Drug Evaluation / Q000379:methods; D054714:Echinocandins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D055666:Lipopeptides; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*; D017582:Renal Replacement Therapy / Q000379:methods*
chemical_list: D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin