title: Adipokines, adiposity, and vasomotor symptoms during the menopause transition: findings from the Study of Women's Health Across the Nation.
abstract: OBJECTIVE
  To test relationships between adipokines, adiposity, and vasomotor symptoms (VMS), including how these associations vary by menopause stage.
  
  
  METHODS
  A subcohort of the longitudinal cohort Study of Women's Health Across the Nation completed questionnaires, physical measures, and a fasting blood draw annually for 8 years. Associations between a poorer adipokine profile (lower adiponectin, lower high-molecular-weight [HMW] adiponectin, higher leptin, lower soluble leptin receptor, higher monocyte chemoattractant protein 1 [MCP-1]) and VMS were tested with the use of generalized estimating equations adjusting for potential confounders. Interactions by menopause stage (pre-/early perimenopause, late peri-/postmenopause) were tested.
  
  
  METHODS
  Community.
  
  
  METHODS
  A total of 536 women ages 42-52 at baseline.
  
  
  METHODS
  None.
  Associations between adipokines and hot flashes varied by menopause stage, with a poorer adipokine profile associated with higher odds of hot flashes early in the transition (adiponectin(log): odds ratio [OR] 0.68, 95% confidence interval [CI] 0.51-0.90; HMW adiponectin(log): OR 0.70, 95% CI 0.58-0.85; leptin(log): OR 1.23, 95% CI 0.99-1.54; multivariable models including body mass index [BMI]), but not later in the transition. The direction of associations between BMI and VMS also varied by menopausal stage. Higher MCP-1 was associated with more night sweats (OR 1.37, 95% CI 1.06-1.76) across menopausal stages.
  
  
  CONCLUSIONS
  An adverse adipokine profile was associated with more VMS, particularly early in the menopause transition.
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. thurstonrc@upmc.edu
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Thurston
authors.forename: Yuefang
authors.initials: Y
authors.lastname: Chang
authors.forename: Peter
authors.initials: P
authors.lastname: Mancuso
authors.forename: Karen A
authors.initials: KA
authors.lastname: Matthews
mesh_terms: D054392:Adipokines / Q000097:blood*; D050154:Adiposity / Q000502:physiology*; D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006728:Hormones / Q000097:blood; D019584:Hot Flashes / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D008137:Longitudinal Studies; D008593:Menopause / Q000097:blood* / Q000502:physiology*; D008875:Middle Aged; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology; D014666:Vasomotor System / Q000502:physiology*; D016387:Women's Health / Q000706:statistics & numerical data
chemical_list: D054392:Adipokines; D006728:Hormones
keywords: Adipokines; adiposity; hot flashes; vasomotor symptoms