title: Potential therapeutic anti-tumor effect of a Salmonella-based vaccine.
abstract: One of the major obstacles to achieving complete eradication of tumors, even in the presence of circulating tumor-specific immunity, is the tumor-induced immunosuppressive environment, which includes myeloid-derived suppressor cells and regulatory T cells. Attenuated microorganisms have emerged as candidates for a novel anti-cancer approach in which they enhance anti-cancer immunity by boosting the innate immune system. Herein, we will discuss current innate-immunity activating strategies for anti-cancer therapy, with a focus on our recently reported approach involving the use of intratumoral injection of recombinant attenuated Salmonella enterica serovar Typhimurium vaccine; this approach elicits transformation of immunosuppressive myeloid-derived suppressor cells into TNF-α-secreting cells with characteristics of neutrophils, and reduces the generation of regulatory T cells, particularly in the presence of tumor-specific cytotoxic T lymphocytes.
authors.affiliation: Laboratory of Microbiology; College of Pharmacy; Ajou University; Suwon, Korea.
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Chang
authors.forename: Yeon-Jeong
authors.initials: YJ
authors.lastname: Kim
authors.forename: Hyun-Jeong
authors.initials: HJ
authors.lastname: Ko
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D022562:Salmonella Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D019496:Cancer Vaccines; D022562:Salmonella Vaccines; D014409:Tumor Necrosis Factor-alpha; D014613:Vaccines, Attenuated
keywords: Salmonella; cytotoxic T lymphocytes; myeloid-derived suppressor cell; regulatory T cell; tumor