title: A new anti-cancer strategy of damaging mitochondria by pro-apoptotic peptide functionalized gold nanoparticles.
abstract: Gold nanoparticles functionalized with pro-apoptotic peptide (PAP-AuNPs) were fabricated, which were able to lead to programmed cell-death by damaging mitochondria.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
authors.forename: Wei-Hai
authors.initials: WH
authors.lastname: Chen
authors.forename: Jing-Xiao
authors.initials: JX
authors.lastname: Chen
authors.forename: Han
authors.initials: H
authors.lastname: Cheng
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Chen
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.forename: Xiao-Ding
authors.initials: XD
authors.lastname: Xu
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Ren-Xi
authors.initials: RX
authors.lastname: Zhuo
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects; D006046:Gold / Q000008:administration & dosage* / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D010455:Peptides; D006046:Gold