title: Dialysate cancer antigen 125 in long-term peritoneal dialysis patients.
abstract: Structural and functional peritoneal membrane changes are associated with long-term peritoneal dialysis. These changes can lead to ultrafiltration failure and peritoneal fibrosis, reducing the efficacy of the peritoneal membrane to remove waste and balance fluid and electrolytes. The loss of mesothelial cells from the basement membrane is one of the major characteristics in peritoneal membrane structural change. Thus, if the reduction of peritoneal mesothelial cell mass in peritoneal dialysis patients is monitored, signs of ultrafiltration failure and peritoneal fibrosis can be detected early. One of biomarkers that can be used to indicate the change in peritoneal mesothelial cell mass is CA125, which is produced by mesothelial cells. In this article, we review the measurement and clinical use of CA125 in peritoneal dialysate effluent. Additionally, we address the data and studies on the association between dialysate CA125 levels and factors related to ultrafiltration failure and peritoneal fibrosis, including the parameters used to monitor the functional status of the peritoneal membrane. Our review shows that dialysate CA125 can be used to evaluate the peritoneal membrane in noninfected patients to predict peritoneal fibrosis, and it can also be used as a biomarker of biocompatible dialysis solutions.
authors.affiliation: Bioactive Resources for Innovative Clinical Applications Research Unit and Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
authors.forename: Panida
authors.initials: P
authors.lastname: Ditsawanon
authors.forename: Ouppatham
authors.initials: O
authors.lastname: Supasyndh
authors.forename: Pornanong
authors.initials: P
authors.lastname: Aramwit
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D018394:CA-125 Antigen / Q000378:metabolism*; D015314:Dialysis Solutions / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D056627:Peritoneal Fibrosis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D010537:Peritoneum / Q000378:metabolism* / Q000473:pathology; D011237:Predictive Value of Tests; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen; D015314:Dialysis Solutions; C451759:MUC16 protein, human; D008565:Membrane Proteins