title: Three new secoiridoids, swermacrolactones A-C and anti-hepatitis B virus activity from Swertia macrosperma.
abstract: Three new secoiridoids, swermacrolactones A-C (1-3), together with fourteen known compounds were isolated from Swertia macrosperma. Their structures were elucidated based on extensive spectroscopic analyses (IR, UV, MS, 1D and 2D NMR). By anti-HBV assay on the Hep G 2.2.15 cell line in vitro, the most active compound, luteolin (9), inhibited the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 0.02 and 0.02 mM, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Wang
authors.forename: Chang-An
authors.initials: CA
authors.lastname: Geng
authors.forename: Yun-Bao
authors.initials: YB
authors.lastname: Ma
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Ji-Jun
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000956:Antigens, Viral / Q000378:metabolism; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D056945:Hep G2 Cells; D006509:Hepatitis B / Q000188:drug therapy / Q000821:virology*; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047311:Luteolin / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D029967:Swertia / Q000737:chemistry*
chemical_list: D000956:Antigens, Viral; D000998:Antiviral Agents; D039823:Iridoids; D010936:Plant Extracts; D047311:Luteolin
keywords: Anti-HBV activity; Gentianaceae; Secoiridoids; Swermacrolactones A–C; Swertia macrosperma