title: Evaluation of phytochemical-incorporated porous polymeric sponges for bone tissue engineering: a novel perspective.
abstract: Porous polymeric scaffolds are extensively studied for delivery of bone growth factors. Since phytochemicals are known to produce changes in cell signalling and other metabolic pathways, osteogenic phytochemicals, that is, extracts of Cissus quadrangularis and Butea monosperma, are incorporated into sulphonated poly(aryl ether ketone) sponges. The results have shown that the scaffolds with phytochemicals enhanced the proliferation and alkaline phosphatase activity of the cells compared to cells treated on scaffolds without phytochemicals. Hence, these phytochemicals can be evaluated to augment, if not substitute the use of bone morphogenetic proteins in scaffolds.
authors.affiliation: Bioproducts Laboratory, Central Leather Research Institute, Chennai, Tamil Nadu, India.
authors.forename: Ravi N
authors.initials: RN
authors.lastname: Raghavan
authors.forename: N
authors.initials: N
authors.lastname: Somanathan
authors.forename: Thottapalli P
authors.initials: TP
authors.lastname: Sastry
mesh_terms: D000469:Alkaline Phosphatase / Q000187:drug effects / Q000378:metabolism; D000880:Anthraquinones / Q000737:chemistry; D001842:Bone and Bones; D031290:Butea / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D032422:Cissus / Q000737:chemistry; D004801:Eosine Yellowish-(YS) / Q000737:chemistry; D006801:Humans; D010078:Oxazines / Q000737:chemistry; D064209:Phytochemicals / Q000494:pharmacology*; D016062:Porosity; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014966:Xanthenes / Q000737:chemistry
chemical_list: D000880:Anthraquinones; D010078:Oxazines; D064209:Phytochemicals; D014966:Xanthenes; C005843:resazurin; C010078:alizarin; D000469:Alkaline Phosphatase; D004801:Eosine Yellowish-(YS)
keywords: Butea; Cissus; SaOS2; bone; osteogenic; phytochemicals; scaffolds; sulphonated poly(aryl ether ketone); tissue engineering