title: Molecular mechanisms regulating NETosis in infection and disease.
abstract: Neutrophils are the foot soldiers of the immune system. They home in to the site of infection and kill pathogens by phagocytosis, degranulation, and the release of web-like structures called neutrophil extracellular traps (NETs) that trap and kill a variety of microbes. NETs have been shown to play a multitude of additional roles in immunity but have also been implicated in inflammatory and autoimmune disease. Here, we discuss the role of NETs in these various contexts with a particular emphasis on the molecular mechanisms that regulate NET release and clearance. We highlight the comprehensive concepts and explore the important open questions in the field.
authors.affiliation: Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, Mill Hill, London, UK.
authors.forename: Nora
authors.initials: N
authors.lastname: Branzk
authors.forename: Venizelos
authors.initials: V
authors.lastname: Papayannopoulos
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015551:Autoimmunity / Q000235:genetics / Q000276:immunology; D005110:Extracellular Space / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism*