title: Reduced white matter integrity and cognitive deficit in never-medicated chronic schizophrenia: a diffusion tensor study using TBSS.
abstract: BACKGROUND
  Disrupted white matter (WM) integrity is the pathological hallmark of schizophrenia. Previous studies have reported the cognitive deficits that are associated with WM disruption in schizophrenia with anti-psychiatric treatment. However, no study has yet revealed the correlation between cognition and WM abnormalities in never-medicated chronic schizophrenia.
  
  
  METHODS
  We used the diffusion tensor imaging (DTI) with tract-based spatial statistics (TBSS) approach to investigate the whole-brain difference in the WM fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) values between 17 schizophrenia patients and 17 healthy controls matched in age, gender and education level. Patients' cognition was assessed through the MATRICS Consensus Cognitive Battery (MCCB). We explored the association between WM reduction and cognitive, clinical characteristics (severity of clinical symptoms, age, age of onset, illness duration).
  
  
  RESULTS
  Voxel-wise statistics revealed that schizophrenia patients showed significant FA reduction in left inferior longitudinal fasciculus (ILF) and left inferior fronto-occipital fasciculus (IFOF), and no difference in MD, AD or RD as compared to healthy subjects. Furthermore, in the patients group, lower FA value of the left ILF and left IFOF significantly correlated with worse processing speed, as well as verbal learning and visual learning abilities. There was no correlation between the FA value and the severity of clinical symptoms, age, and age of onset or illness duration.
  
  
  CONCLUSIONS
  Our results provide evidence to support that the disconnection of WM pathways may contribute to the pathophysiology of schizophrenia and suggest that the disturbance of left ILF and left IFOF integrity may contribute to cognitive deficits in schizophrenia, independent of effects of antipsychotic medication.
authors.affiliation: Department of Radiology, People's Hospital, Peking University, Beijing, China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Liu
authors.forename: Yunyao
authors.initials: Y
authors.lastname: Lai
authors.forename: Xijin
authors.initials: X
authors.lastname: Wang
authors.forename: Chuanxi
authors.initials: C
authors.lastname: Hao
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhou
authors.forename: Xin
authors.initials: X
authors.lastname: Yu
authors.forename: Nan
authors.initials: N
authors.lastname: Hong
mesh_terms: D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D012559:Schizophrenia / Q000150:complications* / Q000473:pathology*; D014706:Verbal Learning
keywords: Cognitive ability; Diffusion tensor imaging; Never-medicated; Schizophrenia; White matter