title: Serotonin2C receptors and drug addiction: focus on cocaine.
abstract: This review provides an overview of the role of central serotonin2C (5-HT2C) receptors in drug addiction, specifically focusing on their impact on the neurochemical and behavioral effects of cocaine, one of the most worldwide abused drug. First, we described the neurochemical and electrophysiological mechanisms underlying the interaction between 5-HT2C receptors and the mesocorticolimbic dopaminergic network, in keeping with the key role of this system in drug abuse and dependence. Thereafter, we focused on the role of 5-HT2C receptors in the effects of cocaine in various preclinical behavioral models used in drug addiction research, such as locomotor hyperactivity, locomotor sensitization, drug discrimination, and self-administration, to end with an overview of the neurochemical mechanisms underlying the interactions between 5-HT2C receptors, mesocorticolimbic dopamine system, and cocaine. On their whole, the presented data provide compelling preclinical evidence that 5-HT2C receptor agonists may have efficacy in the treatment of cocaine abuse and dependence, thereby underlying the need for additional clinical studies to ascertain whether preclinical data translate to the human.
authors.affiliation: Inserm U862, Neurocentre Magendie, Physiopathology of Addiction Group, Bordeaux, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Devroye
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Filip
authors.forename: Edmund
authors.initials: E
authors.lastname: Przegaliński
authors.forename: Andrew C
authors.initials: AC
authors.lastname: McCreary
authors.forename: Umberto
authors.initials: U
authors.lastname: Spampinato
mesh_terms: D000818:Animals; D001519:Behavior / Q000187:drug effects* / Q000502:physiology; D003042:Cocaine / Q000009:adverse effects / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000187:drug effects; D044405:Receptor, Serotonin, 5-HT2C / Q000378:metabolism*; D019966:Substance-Related Disorders / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D044405:Receptor, Serotonin, 5-HT2C; D003042:Cocaine; D004298:Dopamine