title: Wegener granulomatosis as an uncommon cause of panhypopituitarism in childhood.
abstract: Wegener granulomatosis (WG) is a cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA)-associated, multi-system, necrotizing granulomatous vasculitis. Inflammation of the nasal or oral mucosa, and lung and kidney involvements are typical in the course of the disease. In rare cases, pituitary involvement may occur and cause panhypopituitarism. Pituitary involvement is very rare, and only two pediatric case reports have been published to date out of a total of 24 cases. This is a case report of an adolescent patient who presented with panhypopituitarism symptoms and was later diagnosed with WG. A 16-year-old female patient complained of fever, headache, purulent nasal discharge and severe muscle and joint pain. Additionally, she had polyuria and polydipsia. Investigations revealed a pituitary mass and panhypopituitarism. Positivity of c-ANCA and renal biopsy result compatible with WG confirmed the diagnosis.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Kara
authors.forename: Fatma
authors.initials: F
authors.lastname: Demirel
authors.forename: Banu Celikel
authors.initials: BC
authors.lastname: Acar
authors.forename: Nilgün
authors.initials: N
authors.lastname: Cakar
mesh_terms: D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D018771:Arthralgia / Q000209:etiology / Q000517:prevention & control; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006099:Granuloma / Q000209:etiology / Q000517:prevention & control; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology*; D063806:Myalgia / Q000209:etiology / Q000517:prevention & control; D019226:Oral Ulcer / Q000209:etiology / Q000517:prevention & control; D010902:Pituitary Gland / Q000276:immunology / Q000503:physiopathology*; D010911:Pituitary Neoplasms / Q000209:etiology / Q000517:prevention & control; D011507:Proteinuria / Q000209:etiology / Q000517:prevention & control; D012852:Sinusitis / Q000209:etiology / Q000517:prevention & control; D016896:Treatment Outcome; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D018906:Antineoplastic Agents, Alkylating; D005938:Glucocorticoids; D003520:Cyclophosphamide