title: Acute and chronic effects of selective serotonin reuptake inhibitor treatment on fear conditioning: implications for underlying fear circuits.
abstract: Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of a spectrum of anxiety disorders, yet paradoxically they may increase symptoms of anxiety when treatment is first initiated. Despite extensive research over the past 30 years focused on SSRI treatment, the precise mechanisms by which SSRIs exert these opposing acute and chronic effects on anxiety remain unknown. By testing the behavioral effects of SSRI treatment on Pavlovian fear conditioning, a well characterized model of emotional learning, we have the opportunity to identify how SSRIs affect the functioning of specific brain regions, including the amygdala, bed nucleus of the stria terminalis (BNST) and hippocampus. In this review, we first define different stages of learning involved in cued and context fear conditioning and describe the neural circuits underlying these processes. We examine the results of numerous rodent studies investigating how acute SSRI treatment modulates fear learning and relate these effects to the known functions of serotonin in specific brain regions. With these findings, we propose a model by which acute SSRI administration, by altering neural activity in the extended amygdala and hippocampus, enhances both acquisition and expression of cued fear conditioning, but impairs the expression of contextual fear conditioning. Finally, we review the literature examining the effects of chronic SSRI treatment on fear conditioning in rodents and describe how downregulation of N-methyl-d-aspartate (NMDA) receptors in the amygdala and hippocampus may mediate the impairments in fear learning and memory that are reported. While long-term SSRI treatment effectively reduces symptoms of anxiety, their disruptive effects on fear learning should be kept in mind when combining chronic SSRI treatment and learning-based therapies, such as cognitive behavioral therapy.
authors.affiliation: Columbia University, Departments of Neuroscience and Psychiatry, 1051 Riverside Drive, Unit 87, New York, NY 10032, United States. nsb2113@columbia.edu
authors.forename: N S
authors.initials: NS
authors.lastname: Burghardt
authors.forename: E P
authors.initials: EP
authors.lastname: Bauer
mesh_terms: D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D005239:Fear / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009415:Nerve Net / Q000187:drug effects* / Q000502:physiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors
keywords: BA; BLA; BNST; CBT; CE; CS; CeL; CeM; LA; LTM; N-methyl-d-aspartate; NMDA; PL; PTSD; SSRI; STM; US; amygdala; anxiety; basal nucleus of the amygdala; basolateral nucleus; bed nucleus of the stria terminalis; central nucleus; cognitive behavioral therapy; comprised of a lateral; comprised of a medial; conditioned stimulus; fear conditioning; lateral nucleus of the amygdala; long-term memory; post-traumatic stress disorder; prelimbic cortex; selective serotonin reuptake inhibitor; serotonin; short-term memory; unconditioned stimulus