title: Practical aspects and mechanism of asymmetric hydrogenation with chiral half-sandwich complexes.
abstract: This review is oriented toward the asymmetric transfer hydrogenation (ATH) of imines regarding mostly fundamental, yet important topics from the practical point of view. Development of analytical methods for the monitoring of ATH (i.e., kinetics and stereoselectivity) belongs to those topics, as well as studies on the influence of reaction conditions and structural variations on the reaction performance. The second part is devoted to the reaction mechanism with the emphasis on imine ATH and catalyst behaviour under acidic conditions. The review also addresses the asymmetric hydrogenation (AH) of ketones and imines using molecular hydrogen and the application of ATH in pharmaceutical projects. The contributions of our group to each area are included.
authors.affiliation: Department of Organic Technology, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague, Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Václavík
authors.forename: Petr
authors.initials: P
authors.lastname: Sot
authors.forename: Beáta
authors.initials: B
authors.lastname: Vilhanová
authors.forename: Jan
authors.initials: J
authors.lastname: Pecháček
authors.forename: Marek
authors.initials: M
authors.lastname: Kuzma
authors.forename: Petr
authors.initials: P
authors.lastname: Kačer
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D006865:Hydrogenation; D007097:Imines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D007097:Imines; D012428:Ruthenium; D006859:Hydrogen