title: Guidelines for biomarker testing in gastroenteropancreatic neuroendocrine neoplasms: a national consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology.
abstract: The annual incidence of neuroendocrine tumours in the Caucasian population ranges from 2.5 to 5 new cases per 100,000 inhabitants. Gastroenteropancreatic neuroendocrine tumours is a family of neoplasms widely variable in terms of anatomical location, hormone composition, clinical syndromes they cause and in their biological behaviour. This high complexity and clinical heterogeneity, together with the known difficulty of predicting their behaviour from their pathological features, are reflected in the many classifications that have been developed over the years in this field. This article reviews the main tissue and clinical biomarkers and makes recommendations for their use in medical practice. This document represents a consensus reached jointly by the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP).
authors.affiliation: Medical Oncology Department, Virgen del Rocío University Hospital, Biomedicine Institute of Sevilla (IBIS) [University of Sevilla, CSIC, HUVR], Avenida Manuel Siurot, S/N, 41013, Seville, Spain, rgcarbonero@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: García-Carbonero
authors.forename: F
authors.initials: F
authors.lastname: Vilardell
authors.forename: P
authors.initials: P
authors.lastname: Jiménez-Fonseca
authors.forename: R
authors.initials: R
authors.lastname: González-Campora
authors.forename: E
authors.initials: E
authors.lastname: González
authors.forename: M
authors.initials: M
authors.lastname: Cuatrecasas
authors.forename: J
authors.initials: J
authors.lastname: Capdevila
authors.forename: I
authors.initials: I
authors.lastname: Aranda
authors.forename: J
authors.initials: J
authors.lastname: Barriuso
authors.forename: X
authors.initials: X
authors.lastname: Matías-Guiu
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D007414:Intestinal Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor