title: The efficacy and safety of alphacypermethrin as a pour-on treatment for water buffalo (Bubalus bubalis) infested with Haematopinus tuberculatus (Phthiraptera: Haematopinidae).
abstract: The sucking louse Haematopinus tuberculatus (Burmeister 1839) is an ectoparasite of buffaloes, cattle, camels, and American bison. Alphacypermethrin (ACYP) is a pyrethroid insecticide commonly used to control arthropods of veterinary and public health interest. Therapeutics, such as antiparasitic compounds, is often administered to buffaloes based on dosage and intervals recommended for cattle because very few drugs have buffalo-specific label indications. A trial was conducted on 20 louse-infested buffaloes at a farm to assess the efficacy and safety of ACYP pour-on, at the manufacturer's recommended dose for cattle, on buffaloes naturally infested by H. tuberculatus. Ten animals were assigned to ACYP-treated group (ACYP-group) and ten to untreated control group (C-group). On day 0, all ACYP-group buffaloes received alphacypermethrin pour-on. Louse counts were performed on days -1, 7, 14, 21, 28, 35, 42, 49, and 56 at eight predilection sites on the skin of each buffalo. ACYP was completely effective (100%) at day 7, highly effective (99.8%) at day 14, and completely effective (100%) from day 21 until the end of the study (day 56 post-treatment). During the trial, ACYP was well tolerated by all animals as there were no observed clinically adverse reactions. The results of this trial suggest that ACYP is an effective, safe, and user-friendly compound suitable for treatment of buffaloes with natural louse infestations.
authors.affiliation: Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy. vincenzo.veneziano@unina.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Veneziano
authors.forename: Gianluca
authors.initials: G
authors.lastname: Neglia
authors.forename: Roberta
authors.initials: R
authors.lastname: Cimmino
authors.forename: Anna
authors.initials: A
authors.lastname: Balestrieri
authors.forename: Domenico
authors.initials: D
authors.lastname: Rufrano
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bastianetto
authors.forename: Mario
authors.initials: M
authors.lastname: Santoro
authors.forename: Cengiz
authors.initials: C
authors.lastname: Gokbulut
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002020:Buffaloes; D007306:Insecticides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010373:Lice Infestations / Q000188:drug therapy / Q000662:veterinary*; D008003:Phthiraptera / Q000145:classification*; D011722:Pyrethrins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D007306:Insecticides; D011722:Pyrethrins; C017160:cypermethrin