title: Quality of life following remission of mental disorders: findings from the National Epidemiologic Survey on Alcohol and Related Conditions.
abstract: OBJECTIVE
  Although psychiatric disorders are associated with decreased health-related quality of life, it is unknown whether symptom remission is associated with its improvement or normalization.
  
  
  METHODS
  Data were derived from the National Epidemiologic Survey on Alcohol and Related Conditions, a large national sample of the United States population. A total of 34,653 adults 18 years and older residing in households completed 2 waves (2001-2002 and 2004-2005) of face-to-face surveys. DSM-IV psychiatric diagnoses of mood, anxiety, and substance use disorders were based on the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV Version. Health-related quality of life was assessed with the Short Form-12 Health Survey, Version 2 (SF-12).
  
  
  RESULTS
  Remission from alcohol dependence, major depressive disorder, bipolar disorder, dysthymia, social anxiety disorder, and generalized anxiety disorder was associated with significant improvement in SF-12 scores compared to nonremission (ranging from β = 7.28 in dysthymia to β = 3.16 in social anxiety disorder, all P < .05). However, with the exception of alcohol abuse, individuals who had remitted from all other disorders had lower SF-12 scores than individuals without lifetime history of the disorder. Furthermore, remission of alcohol abuse, cannabis use disorder, nicotine dependence, panic disorder, and specific phobia was not associated with significant improvement in SF-12 scores.
  
  
  CONCLUSIONS
  The relationship between psychiatric disorders and health-related quality of life is complex and differs across disorders. Although remission of several psychiatric disorders was associated with significant improvements, remission was generally not associated with full restoration of health-related quality of life, even among those without comorbid disorders.
authors.affiliation: New York State Psychiatric Institute, New York, NY 10032, USA. lorente01@gmail.com
authors.forename: Jose M
authors.initials: JM
authors.lastname: Rubio
authors.forename: Mark
authors.initials: M
authors.lastname: Olfson
authors.forename: Laura
authors.initials: L
authors.lastname: Villegas
authors.forename: Gabriela
authors.initials: G
authors.lastname: Pérez-Fuentes
authors.forename: Shuai
authors.initials: S
authors.lastname: Wang
authors.forename: Carlos
authors.initials: C
authors.lastname: Blanco
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy*; D004185:Disability Evaluation; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012074:Remission Induction; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology; D055815:Young Adult