title: Design and validation of two optical beacons for guidewire localization in breast-conserving surgery.
abstract: Stereotactically placed guidewires are used for indicating the location of a nonpalpable carcinoma in breast-conserving surgery. Pathologists use the end of the embedded guidewire to guide sectioning during intraoperative margin assessment, but they do not currently have a tool to indicate the location of the guidewire end for informed sectioning. We present analysis and experimental testing of two optical methods for localizing the end of an embedded fiber-optic guidewire: the first uses irradiance emitted from the fiber to indicate the location of the guidewire end, while the second system uses the fiber optic to create a photoacoustic pulse for localization. Both systems locate the end of the guidewire within ±5 mm, which ensures that the lesion of interest is bisected during sectioning. The accuracy of the irradiance-based beacon is influenced by standard margin paints, so the photoacoustic beacon proved more useful under current tissue-handling protocols.
authors.affiliation: The Institute of Optics, University of Rochester, Rochester, New York 14627, USA.
authors.forename: Rebecca Anne
authors.initials: RA
authors.lastname: Wilson
authors.forename: Stephen A
authors.initials: SA
authors.lastname: McAleavey
authors.forename: Linda M
authors.initials: LM
authors.lastname: Schiffhauer
authors.forename: James
authors.initials: J
authors.lastname: Zavislan
mesh_terms: D000818:Animals; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D057918:Fiducial Markers; D007834:Lasers; D008029:Lighting / Q000295:instrumentation*; D015412:Mastectomy, Segmental / Q000295:instrumentation*; D010783:Photometry / Q000295:instrumentation*; D013238:Stereotaxic Techniques / Q000295:instrumentation*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D013552:Swine