title: Geriatric assessment in older patients with acute myeloid leukemia: a retrospective study of associated treatment and outcomes.
abstract: We explored whether geriatric assessment variables predicted mortality in addition to known prognostic factors in 101 patients aged ≥ 65 with newly diagnosed AML. Baseline comorbidity score (HR=1.92; 95%CI 1.18-3.11), difficulty with strenuous activity (HR=2.18; 95%CI 1.19-4.00), and pain (HR=2.17; 95%CI 1.19-3.97) were independent prognostic factors for greater risk of death in a multivariable model that included cytogenetic risk group. They remained independent predictors in the subset of patients with baseline ECOG PS 0-1. Our results support the use of geriatric assessment to better predict prognosis in older patients with AML, even among those with excellent functional status.
authors.affiliation: College of Medicine, University of Cincinnati, Cincinnati, OH, United States.
authors.forename: Alexander E
authors.initials: AE
authors.lastname: Sherman
authors.forename: Gabriela
authors.initials: G
authors.lastname: Motyckova
authors.forename: K Rebecca
authors.initials: KR
authors.lastname: Fega
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Deangelo
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Abel
authors.forename: David
authors.initials: D
authors.lastname: Steensma
authors.forename: Martha
authors.initials: M
authors.lastname: Wadleigh
authors.forename: Richard M
authors.initials: RM
authors.lastname: Stone
authors.forename: Jane A
authors.initials: JA
authors.lastname: Driver
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D015577:Geriatric Assessment; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000401:mortality* / Q000628:therapy*; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Acute; Comorbidity; Geriatric assessment; Leukemia; Myeloid; Performance status; Prognosis