title: A case of newly diagnosed primary hypothyroidism with deteriorating consciousness that did not respond to thyroxine--what else should be considered?
abstract: We present an unusual case of a 60 year old male who was noted to have primary hypothyroidism and decreased consciousness which did not respond to Levothyroxine. Further investigations revealed a diagnosis of Hashimoto's Encephalopathy which responded well to steroids. We describe the case in detail and discuss the available relevant literature on this topic.
authors.affiliation: Wrexham Maelor Hospital, Wrexham, UK.
authors.forename: Aled
authors.initials: A
authors.lastname: Williams
authors.forename: Nikki
authors.initials: N
authors.lastname: Green
authors.forename: Cho Thae
authors.initials: CT
authors.lastname: Phyu
authors.forename: Rao
authors.initials: R
authors.lastname: Bondugulapati
authors.forename: A N
authors.initials: AN
authors.lastname: Dixon
authors.forename: John
authors.initials: J
authors.lastname: Harvey
mesh_terms: D001927:Brain Diseases / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D003243:Consciousness; D003937:Diagnosis, Differential; D004569:Electroencephalography / Q000379:methods; D004660:Encephalitis; D005938:Glucocorticoids / Q000627:therapeutic use; D050031:Hashimoto Disease / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D013974:Thyroxine / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D013974:Thyroxine; D008775:Methylprednisolone