title: AlCl3-mediated hydroarylation-heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest.
abstract: An unprecedented AlCl3-mediated method has been developed involving aromatic C-H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.
authors.affiliation: Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India.
authors.forename: Ali
authors.initials: A
authors.lastname: Nakhi
authors.forename: Sivakumar
authors.initials: S
authors.lastname: Archana
authors.forename: Guru Pavan Kumar
authors.initials: GP
authors.lastname: Seerapu
authors.forename: Keerthana Sarma
authors.initials: KS
authors.lastname: Chennubhotla
authors.forename: Kummari Lalith
authors.initials: KL
authors.lastname: Kumar
authors.forename: Pushkar
authors.initials: P
authors.lastname: Kulkarni
authors.forename: Devyani
authors.initials: D
authors.lastname: Haldar
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002712:Chlorides / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011810:Quinoxalines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D037761:Sirtuins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D015027:Zebrafish
chemical_list: D000475:Alkenes; D017607:Aluminum Compounds; D000970:Antineoplastic Agents; D002712:Chlorides; D004791:Enzyme Inhibitors; D011810:Quinoxalines; D000077410:Aluminum Chloride; D037761:Sirtuins