title: A case of migraine without aura that was successfully treated with an herbal medicine.
abstract: OBJECTIVE
  Migraine is a common neurologic condition characterized by the disabling effects it has on the patient. Despite recent progress in drug development, better pharmacotherapies against migraine are still needed. This report describes an herbal medicine that has a strong pain-relieving effect against migraine.
  
  
  METHODS
  This case involved a 49-year-old woman with a 16-year history of headaches. Migraine without aura had been diagnosed at age 47 years. Despite taking antiepileptic drugs as prophylaxis, she had migraines almost three times a week, especially in the morning. As a result, 3 months before her visit to the study clinic she was prescribed sumatriptan, which she had to take for each attack. However, sumatriptan sometimes failed to work as a painkiller, and the patient did not want to continue taking it because she was worried about overuse.
  
  
  RESULTS
  According to traditional Japanese (Kampo) and Chinese herbal medicine, the patient was prescribed an oral sanno-shashin-to (Xie Xin Tang) extract formula to take at night to prevent her migraines. Soon after she started taking the formula, the intensity of her morning headaches markedly decreased, to the extent that triptans were no longer needed. Furthermore, her residual headaches quickly disappeared after the additional administration of the formula in the morning.
  
  
  CONCLUSIONS
  Sanno-shashin-to might have both prophylactic and therapeutic effects against migraine without aura. Although the underlying mechanism behind the effectiveness of this herbal medicine against migraine has not been fully elucidated, it is a possible option for the treatment of this type of headache.
authors.affiliation: 1 Division of Traditional Japanese Medicine, Nippon Medical School Hospital , Sendagi, Bunkyo-ku, Tokyo, Japan .
authors.forename: Shun
authors.initials: S
authors.lastname: Takaku
authors.forename: Eiichi
authors.initials: E
authors.lastname: Osono
authors.forename: Hideki
authors.initials: H
authors.lastname: Kuribayashi
authors.forename: Chizuno
authors.initials: C
authors.lastname: Takaku
authors.forename: Naoki
authors.initials: N
authors.lastname: Hirama
authors.forename: Hidemi
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D001599:Berberine / Q000627:therapeutic use*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D020326:Migraine without Aura / Q000188:drug therapy* / Q000503:physiopathology; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C062798:sannoshashinto; D001599:Berberine