title: [Transformations of dinitrosyl iron complexes in an isolated rat heart after introduction of this substance into perfusion medium].
abstract: The objective of the present research was to study transformations of various physiological NO forms in an isolated rat heart, perfused with the medium, containing dinitrosyl iron complexes with glutathione ligand (DNIC-GH). We showed that such aerobic perfusion resulted in accumulation of mostly diamagnetic NO physiological forms (S-nitrosothiols) in myocardial tissue. They were transformed into protein-bound mononuclear dinitrosyl iron complexes during subsequent total ischemia. Meantime, DNIC-GH injection on the onset of ischemia resulted in the changes in the state of mitochondrial respiratory state, characterized by the increase in myocardial concentration of flavosemiquinones.
authors.forename: A A
authors.initials: AA
authors.lastname: Timoshina
authors.forename: V L
authors.initials: VL
authors.lastname: Lakomkin
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Drobotova
authors.forename: E K
authors.initials: EK
authors.lastname: Ruuge
authors.forename: A F
authors.initials: AF
authors.lastname: Vanin
mesh_terms: D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D005978:Glutathione / Q000737:chemistry; D006321:Heart / Q000187:drug effects; D007501:Iron / Q000737:chemistry* / Q000494:pharmacology; D007511:Ischemia; D008024:Ligands; D008929:Mitochondria, Heart / Q000737:chemistry / Q000187:drug effects; D009206:Myocardium / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry*; D009589:Nitrogen Oxides / Q000737:chemistry* / Q000494:pharmacology; D009924:Organ Culture Techniques; D010477:Perfusion; D011809:Quinones / Q000737:chemistry; D051381:Rats; D026403:S-Nitrosothiols / Q000737:chemistry*
chemical_list: D008024:Ligands; D009589:Nitrogen Oxides; D011809:Quinones; D026403:S-Nitrosothiols; C001636:flavosemiquinone; D009569:Nitric Oxide; C073661:dinitrosyl iron complex; D007501:Iron; D005978:Glutathione