title: Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation.
abstract: ADP-ribosylation of proteins was first described in the early 1960's, and today the function and regulation of poly(ADP-ribosyl)ation (PARylation) is partially understood. By contrast, little is known about intracellular mono(ADP-ribosyl)ation (MARylation) by ADP-ribosyl transferase (ART) enzymes, such as ARTD10. Recent findings indicate that MARylation regulates signalling and transcription by modifying key components in these processes. Emerging evidence also suggests that specific macrodomain-containing proteins, including ARTD8, macroD1, macroD2 and C6orf130, which are distinct from those affecting PARylation, interact with MARylation on target proteins to 'read' and 'erase' this modification. Thus, studying macrodomain-containing proteins is key to understanding the function and regulation of MARylation.
authors.affiliation: Institute of Biochemistry and Molecular Biology, Rheinisch-Westfaelische Technische Hochschule (RWTH) Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
authors.forename: Karla L H
authors.initials: KL
authors.lastname: Feijs
authors.forename: Alexandra H
authors.initials: AH
authors.lastname: Forst
authors.forename: Patricia
authors.initials: P
authors.lastname: Verheugd
authors.forename: Bernhard
authors.initials: B
authors.lastname: Lüscher
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D014158:Transcription, Genetic; D056811:Unfolded Protein Response
chemical_list: D000246:Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases