title: Synthesis and antifungal evaluation of (1,2,3-triazol-4-yl)methyl nicotinate chitosan.
abstract: With an aim to discover novel chitosan derivatives with significant activities against crop-threatening fungi, (1,2,3-triazol-4-yl)methyl nicotinate chitosan (TAMNCS) was prepared via azide-alkyne click reaction. Its structure was characterized by FT-IR, (1)H NMR, elemental analysis, DSC, and SEM. In vitro antifungal properties of TAMNCS against Rhizoctonia solani Kühn (R. solani), Stemphylium solani weber (S. solani), and Alternaria porri (A. porri) were studied at the concentrations ranged from 0.25 mg/mL to 1.0 mg/mL. Experiments conducted displayed the derivative had obviously enhanced antifungal activity after chemical modification compared with original chitosan. Moreover, it was shown that TAMNCS can 94.2% inhibit growth of A. porri at 1.0 mg/mL, while dose at which the fungicide triadimefon had lower inhibitory index (62.2%). The primary antifungal results described here indicate this derivative may be a promising candidate as an antifungal agent.
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors.forename: Yukun
authors.initials: Y
authors.lastname: Qin
authors.forename: Song
authors.initials: S
authors.lastname: Liu
authors.forename: Ronge
authors.initials: R
authors.lastname: Xing
authors.forename: Kecheng
authors.initials: K
authors.lastname: Li
authors.forename: Huahua
authors.initials: H
authors.lastname: Yu
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Li
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D048271:Chitosan / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000935:Antifungal Agents; D048271:Chitosan
keywords: 1,2,3-Triazole; Antifungal activity; Characterization; Chitosan; Click reaction