title: Changes in maternal lipid peroxidation before and immediately after delivery.
abstract: Oxidative damage has been implicated in pathogenesis of many diseases. It is known that various kinds of stresses accelerate the production of free radicals. As pregnancy being a physiological state accompanied by a high energy demand of many bodily functions and an increased oxygen requirement, increased level of oxidative stress would be expected. The present study was to elucidate the degree of oxidative stress during labour and immediately after delivery. Twenty healthy pregnant women and age matched and 20 healthy non-pregnant women were selected as subjects for this longitudinal study. Plasma malondialdehyde concentration was estimated as thiobarbituric acid reacting substances. A significant (p < 0.01) increase in plasma malondialdehyde concentration was noted in pregnant women during labour than in the non-pregnant women. Plasma malondialdehyde concentration was noted to increase with the progression and duration of labour to immediately following delivery. Labour being stressful state results in oxidative stress, which increased with increase in duration and progression of the labour till immediately following delivery.
authors.affiliation: Department of Physiology, Sri Ramachandra Medical College and Research Institute, Chennai 600116.
authors.forename: Jessy
authors.initials: J
authors.lastname: John
authors.forename: D C
authors.initials: DC
authors.lastname: Mathangi
authors.forename: K
authors.initials: K
authors.lastname: Dilara
authors.forename: A S
authors.initials: AS
authors.lastname: Subhashini
authors.forename: Jaya
authors.initials: J
authors.lastname: Vijayraghavan
mesh_terms: D000328:Adult; D015415:Biomarkers; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000097:blood*; D015227:Lipid Peroxidation; D008137:Longitudinal Studies; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D036801:Parturition / Q000097:blood*; D011247:Pregnancy; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D015415:Biomarkers; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde