title: IL-10RB rs2834167 (A/G) polymorphism is associated with the susceptibility to systemic lupus erythematosus: evidence from a study in Chinese Han population.
abstract: Interleukin-10 (IL-10) is a pleiotropic cytokine and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Unlike IL-10 protein, few studies have focused on the potential association between IL-10 receptor (IL-10R) and SLE. The purpose of this study was to examine the association of a single nucleotide polymorphism, rs2834167 (A/G), in IL-10R2 gene (IL-10RB) with SLE in a Chinese Han population. A total of 667 patients with SLE and 676 healthy controls were enrolled in the present study. IL-10RB rs2834167 (A/G) polymorphism was specified from genomic DNA using TaqMan genotyping assay on a 7300 real-time reverse transcription polymerase chain reaction system. We found that the frequency of A allele for rs2834167 in patients (44.53 %) was significantly higher than in controls (40.16 %) (χ (2) = 5.24, P = 0.022). Allele A was associated with a 1.196-fold (95 % confidence interval (CI), 1.026-1.394) greater risk for the occurrence of SLE compared with the G allele. And both genotypes AG and AA were associated with the susceptibility to SLE as compared with the GG genotype (AG versus GG, odds ratio (OR) = 1.332; 95 %CI, 1.047-1.696; AA versus GG, OR = 1.373; 95 %CI, 1.004-1.878). We also found a statistical significance in the dominant model (AA + AG versus GG, OR = 1.343; 95 %CI, 1.070-1.687). However, no significant evidence for the association of IL-10RB rs2834167 (A/G) polymorphism with any clinical manifestations was detected. Our observations indicate that IL-10RB rs2834167 (A/G) polymorphism may be a potential biomarker for susceptibility to SLE.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Peng
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Liu
authors.forename: Mo
authors.initials: M
authors.lastname: Zhou
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Wen
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Qiu
authors.forename: Jing
authors.initials: J
authors.lastname: Ni
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053710:Interleukin-10 Receptor beta Subunit / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: D005819:Genetic Markers; D053710:Interleukin-10 Receptor beta Subunit