title: Bactericidal activity of starch-encapsulated gold nanoparticles.
abstract: We report the bactericidal applications of eco-friendly starch encapsulated gold nanoparticles (St-AuNPs). The mechanism of interaction of the properly characterized St-AuNPs with both Gram negative and Gram positive bacteria were investigated using spread plate assay, transmission electron microscopy (TEM), and fluorescent propidium iodide (PI) exclusion assay. The St-AuNPs were found to possess significant dose dependent antibacterial activity against both types of bacteria. St-AuNPs at 1.2 mg/mL caused 98 % eradication of Gram positive bacteria that was exposed over a period of 12 h. Similarly, 4.8 mg/mL St-AuNPs caused 98 % eradication of Gram negative bacteria over a period of 12h. The St-AuNPs are biocompatible and present a useful solid porous carbohydrate-based polymer vehicle with excellent antimicrobial activity against [Frontiers in Bioscience 18, 982-992, June 1, 2013].
authors.affiliation: Department of Chemistry, Western Kentucky University, Bowling Green, KY 42101-1079, USA.
authors.forename: Dillon S
authors.initials: DS
authors.lastname: Pender
authors.forename: Lakshmisri M
authors.initials: LM
authors.lastname: Vangala
authors.forename: Vivek D
authors.initials: VD
authors.lastname: Badwaik
authors.forename: Chad B
authors.initials: CB
authors.lastname: Willis
authors.forename: Zoraida P
authors.initials: ZP
authors.lastname: Aguilar
authors.forename: Tejas N
authors.initials: TN
authors.lastname: Sangoi
authors.forename: Rammohan
authors.initials: R
authors.lastname: Paripelly
authors.forename: Rajalingam
authors.initials: R
authors.lastname: Dakshinamurthy
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles; D008826:Microbial Sensitivity Tests; D046529:Microscopy, Electron, Transmission
chemical_list: D006046:Gold