title: Helicobacter pylori research: historical insights and future directions.
abstract: Helicobacter pylori leads to chronic gastritis, peptic ulcer disease and gastric cancer. With increasing issues of antibiotic resistance and changing epidemiology of this pathogen, new approaches are needed for effective management. In 1984, Dr Barry Marshall and Dr Robin Warren reported the association of Helicobacter pylori with peptic ulcers in The Lancet--a discovery that earned them the Nobel prize in Physiology or Medicine in 2005--but what progress have we made since then? Here, we have invited three international experts to give their insights into the advances in H. pylori research over the past 30 years and where research should be focused in the future.
authors.affiliation: Changi General Hospital, 2 Semei Street 3, Singapore 529889. kwong_ming_fock@cgh.com.sg
authors.forename: Kwong Ming
authors.initials: KM
authors.lastname: Fock
authors.forename: David Y
authors.initials: DY
authors.lastname: Graham
authors.forename: Peter
authors.initials: P
authors.lastname: Malfertheiner
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002908:Chronic Disease; D024881:Drug Resistance, Bacterial; D005756:Gastritis / Q000188:drug therapy / Q000382:microbiology*; D005762:Gastroenterology / Q000639:trends*; D016481:Helicobacter Infections / Q000188:drug therapy / Q000382:microbiology*; D016480:Helicobacter pylori / Q000254:growth & development*; D006801:Humans; D008828:Microbiological Techniques / Q000639:trends*; D064307:Microbiota; D010437:Peptic Ulcer / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents