title: Role of 5-HT5A receptors in the consolidation of memory.
abstract: 5-HT5 receptor occurs in brain areas implicated in learning and memory. Hence, the effects (0.01-3.0 mg/kg) of SB-6995516 (a 5-HT5A receptor antagonist) in the associative learning task of autoshaping were studied. The results showed that post-training injection of SB-699551 decreased conditioned responses (CR) during short-term (STM; 1.5h; at 0.1mg/kg) and long-term memory (LTM; 24 h; at 3.0 mg/kg) relative to the vehicle animals. Moreover, considering that there are no selective 5-HT5A receptor agonists, next, diverse doses of the serotonin precursor l-tryptophan were studied during STM and LTM, showing that l-tryptophan (5-100mg/kg) facilitated performance, particularly at 50mg/kg. In interactions experiments, l-tryptophan (50 mg/kg) attenuated the impairment effect induced by SB-699551 (either 0.3 or 3.0 mg/kg). All together this evidence suggests that the blockade of 5-HT5A receptor appear to be able to impair STM and LTM (24 h), while its stimulation might facilitate it. Of course further investigation is necessary, meanly with selective 5-HT5A compounds are necessary.
authors.affiliation: Dept Pharmacobiol CINVESTAV-IPN, México City, 14330, México.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gonzalez
authors.forename: Karla
authors.initials: K
authors.lastname: Chávez-Pascacio
authors.forename: Alfredo
authors.initials: A
authors.lastname: Meneses
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000378:metabolism*; D012054:Reinforcement, Psychology; D012702:Serotonin Antagonists / Q000494:pharmacology; D013997:Time Factors; D014364:Tryptophan / Q000494:pharmacology
chemical_list: D001713:Biphenyl Compounds; D011985:Receptors, Serotonin; C515421:SB-699551-A; D012702:Serotonin Antagonists; C078730:serotonin 5 receptor; D014364:Tryptophan
keywords: 5-HT Receptors; Autoshaping; Learning rat