title: Novel regulator of enterohepatic bile acid signaling protects against hypercholesterolemia.
abstract: Hypercholesterolemia is a major cause of cardiovascular disease and can be treated by targeting bile acid and cholesterol metabolism. Vergnes et al. (2013) now identify Diet1 as a novel regulator of fibroblast growth factor 15/19 production and bile acid biosynthesis.
authors.affiliation: Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: pdawson@wakehealth.edu.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Dawson
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism
chemical_list: D001647:Bile Acids and Salts; D002352:Carrier Proteins; C585655:Diet1 protein, mouse; C108526:fibroblast growth factor 15, mouse; D005346:Fibroblast Growth Factors; D002790:Cholesterol 7-alpha-Hydroxylase; C502772:Cyp7a1 protein, mouse