title: Associations between genetic polymorphisms of paraoxonase genes and coronary artery disease in a Taiwanese population.
abstract: OBJECTIVE
  We evaluated the relationship between polymorphisms of the paraoxonase (PON) gene and the risk of coronary artery disease (CAD) in Taiwanese patients.
  
  
  METHODS
  Our sample set included 369 volunteers, classified into two groups: 162 healthy volunteers and 207 CAD patients aged 60.0 ± 9.7 and 64.3 ± 12.3 years, respectively. Polymorphisms of the PON1 and PON2 genes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques.
  
  
  RESULTS
  The results indicate that for the PON1 gene, the homozygous genotype RR was found significantly more often among the CAD group compared with the healthy group (OR=1.965, 95% CI=1.223-3.159, p=0.005). Furthermore, for the PON2 gene, the homozygous genotype CC was found significantly more often among the CAD group compared with the control group (OR=2.525, 95% CI=1.103-5.780, p=0.026).
  
  
  CONCLUSIONS
  Individuals homozygous for the R allele of the PON1 gene and the C allele of the PON2 gene are more likely to have an increased risk of CAD.
authors.affiliation: Department of Pathology and Laboratory Medicine, Landseed Hospital, Taoyuan, Taiwan.
authors.forename: Chi-Ching
authors.initials: CC
authors.lastname: Chen
authors.forename: Chien-Chung
authors.initials: CC
authors.lastname: Chen
authors.forename: Jun-Da
authors.initials: JD
authors.lastname: Tu
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Wu
authors.forename: Sy-Jye
authors.initials: SJ
authors.lastname: Leu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D043303:Aryldialkylphosphatase / Q000235:genetics*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000201:enzymology* / Q000235:genetics*; D003710:Demography; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013624:Taiwan
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; C468411:PON2 protein, human
keywords: CAD; Gene polymorphisms; PON1; PON2; Paraoxonase