title: In vivo anti-radiation activities of the Ulva pertusa polysaccharides and polysaccharide-iron(III) complex.
abstract: Polysaccharides with different molecular weights were extracted from Ulva pertusa and fractionated by ultrafiltration. Iron(III) complex of the low molecular-weight U. pertusa polysaccharides were synthesized. Atomic absorption spectrum showed that the iron content of iron(III)-polysaccharide complex was 27.4%. The comparison between U. pertusa polysaccharides and their iron(III) complex showed that iron chelating altered the structural characteristics of the polysaccharides. The bioactivity analysis showed that polysaccharide with low molecular weight was more effective than polysaccharide with high molecular weight in protecting mice from radiation induced damages on bone marrow cells and immune system. Results also proved that the anti-radiation and anti-oxidative activity of iron(III) complex of low molecular-weight polysaccharides were not less than that of low molecular-weight polysaccharides.
authors.affiliation: College of Life Science, Northeast Forestry University, Harbin, PR China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Shi
authors.forename: Cuilin
authors.initials: C
authors.lastname: Cheng
authors.forename: Haitian
authors.initials: H
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Jing
authors.forename: Ning
authors.initials: N
authors.lastname: Gong
authors.forename: Weihong
authors.initials: W
authors.lastname: Lu
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects / Q000528:radiation effects; D008970:Molecular Weight; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology* / Q000648:ultrastructure; D011837:Radiation-Protective Agents / Q000737:chemistry* / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013154:Spleen / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D013482:Superoxide Dismutase / Q000378:metabolism; D044445:Ulva / Q000737:chemistry*
chemical_list: D005290:Ferric Compounds; D011134:Polysaccharides; D011837:Radiation-Protective Agents; D008315:Malondialdehyde; D013482:Superoxide Dismutase
keywords: Iron complex; Multifunctional food; Polysaccharides; Radiation damage; Ulva pertusa