title: Biomarker profiling for lupus nephritis.
abstract: Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE), which is associated with significant morbidity and mortality of SLE patients. The pathogenesis of LN involves multiple factors, including genetic predisposition, epigenetic regulation and environmental interaction. Over the last decade, omics-based techniques have been extensively utilized for biomarker screening and a wide variety of variations which are associated with SLE and LN have been identified at the levels of genomics, transcriptomics and proteomics. These studies and discoveries have expanded our understanding of the molecular basis of the disease and are important for identification of potential therapeutic targets for disease prediction and early treatment. In this review, we summarize some of the recent studies targeted at the identification of LN-associated biomarkers using genomics and proteomic approaches.
authors.affiliation: Department of Immunology and Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Yajuan
authors.initials: Y
authors.lastname: Li
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Fang
authors.forename: Quan-Zhen
authors.initials: QZ
authors.lastname: Li
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D059647:Gene-Environment Interaction; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008181:Lupus Nephritis / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D020543:Proteome / Q000378:metabolism*; D059467:Transcriptome
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D006657:Histones; D035683:MicroRNAs; D020543:Proteome