title: Synthesis of a 2(1H)-pyridone library via rhodium-catalyzed formation of isomunchones.
abstract: Through the use of the dipolar cycloaddition of isomunchones with olefins the 2(1H)-pyridone ring system has been synthesized. (1) The use of different cyclization partners followed by diversification of the initial scaffold has provided libraries of 4-hydroxy-2(1H)-pyridones. There are no examples of this ring system in either PubChem or the MLSMR.
authors.affiliation: Department of Chemistry, University of Houston , Houston Texas 77204-5003, United States.
authors.forename: Subhasis
authors.initials: S
authors.lastname: De
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.forename: Shuxing
authors.initials: S
authors.lastname: Zhang
authors.forename: Scott R
authors.initials: SR
authors.lastname: Gilbertson
mesh_terms: D002384:Catalysis; D003500:Cyclization; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011728:Pyridones; D054852:Small Molecule Libraries; D012238:Rhodium