title: Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population.
abstract: To identify genetic risk factors underlying non-Hodgkin lymphomas (NHLs) from the B cell lineage, we conducted a genome-wide association study (GWAS) of 253 Chinese individuals with B cell NHL (cases) and 1,438 controls and further validation in 1,175 cases and 5,492 controls. We identified a new susceptibility locus, rs6773854, located between BCL6 (encoding B cell lymphoma protein 6) and LPP (encoding lipoma preferred partner) on oncogene-rich chromosome 3q27 that was significantly associated with increased risk of B cell NHL (meta-analysis P = 3.36 × 10⁻¹³, per-allele odds ratio (OR) = 1.44) and with diffuse large B cell lymphoma (DLBCL) in particular (meta-analysis P = 1.14 × 10⁻¹¹, OR = 1.47). We found no evidence of association of rs6773854 with non-B cell NHLs (T cell and natural killer (NK) lineages) (P = 0.17, OR = 1.12) and observed significant heterogeneity between B cell and non-B cell subtypes (Phet = 0.01, I² = 84%). Our results provide insight that germline variation in the intergenic region between BCL6 and LPP has a role in risk of B cell lymphomagenesis.
authors.affiliation: Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore.
authors.forename: Dennis E K
authors.initials: DE
authors.lastname: Tan
authors.forename: Jia Nee
authors.initials: JN
authors.lastname: Foo
authors.forename: Jin-Xin
authors.initials: JX
authors.lastname: Bei
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
authors.forename: Roujun
authors.initials: R
authors.lastname: Peng
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zheng
authors.forename: Lixuan
authors.initials: L
authors.lastname: Wei
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Wei Yen
authors.initials: WY
authors.lastname: Lim
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Cui
authors.forename: Soo Hong
authors.initials: SH
authors.lastname: Chew
authors.forename: Richard P
authors.initials: RP
authors.lastname: Ebstein
authors.forename: Ponnudurai
authors.initials: P
authors.lastname: Kuperan
authors.forename: Soon Thye
authors.initials: ST
authors.lastname: Lim
authors.forename: Miriam
authors.initials: M
authors.lastname: Tao
authors.forename: Suat Hoon
authors.initials: SH
authors.lastname: Tan
authors.forename: Alvin
authors.initials: A
authors.lastname: Wong
authors.forename: Gee Chuan
authors.initials: GC
authors.lastname: Wong
authors.forename: Soo Yong
authors.initials: SY
authors.lastname: Tan
authors.forename: Siok Bian
authors.initials: SB
authors.lastname: Ng
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Zeng
authors.forename: Chiea Chuen
authors.initials: CC
authors.lastname: Khor
authors.forename: Dongxin
authors.initials: D
authors.lastname: Lin
authors.forename: Adeline L H
authors.initials: AL
authors.lastname: Seow
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Jia
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D016393:Lymphoma, B-Cell / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D054928:Validation Studies as Topic; D055815:Young Adult