title: Development of tartaric acid derived chiral guanidines and their application to catalytic enantioselective α-hydroxylation of β-dicarbonyl compounds.
abstract: A novel library of chiral guanidines featuring a tartaric acid skeleton was developed from diethyl l-tartrate. These guanidines are easily accessed with tunable steric and electronic properties. The utilities of the guanidines were highlighted by their ability to catalyze the α-hydroxylation of β-ketoesters and β-diketones with remarkable efficiency and excellent enantioselectivity.
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology , Dalian 116024, P. R. China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Zou
authors.forename: Baomin
authors.initials: B
authors.lastname: Wang
authors.forename: Hongfang
authors.initials: H
authors.lastname: Mu
authors.forename: Huanrui
authors.initials: H
authors.lastname: Zhang
authors.forename: Yuming
authors.initials: Y
authors.lastname: Song
authors.forename: Jingping
authors.initials: J
authors.lastname: Qu