title: A magnetoplasmonic imaging agent for copper(I) with dual response by MRI and dark field microscopy.
abstract: We present the design and synthesis of a responsive magnetoplasmonic assembly for copper(I) which allows monitoring of the concentration of the metal both in three dimensions by magnetic resonance imaging and with high spatial resolution by dark field microscopy. The probe consists of azide-functionalized iron oxide nanoparticles 11.6 nm in diameter and acetylene-terminated gold nanoparticles 44 nm in diameter that form three-dimensional networks of intermingled magnetic and plasmonic nanoparticles in the presence of copper. This aggregation results in a decrease in longitudinal relaxivity, and an initial increase followed by a sharp decrease in transverse relaxivity, a change observable both by T1- and T2-weighted images, concomitantly with a decrease of surface plasmon resonance intensity.
authors.affiliation: Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Evan A
authors.initials: EA
authors.lastname: Weitz
authors.forename: Cutler
authors.initials: C
authors.lastname: Lewandowski
authors.forename: Eric D
authors.initials: ED
authors.lastname: Smolensky
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Marjańska
authors.forename: Valérie C
authors.initials: VC
authors.lastname: Pierre
mesh_terms: D003287:Contrast Media; D003300:Copper / Q000032:analysis*; D006046:Gold / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008853:Microscopy / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D020349:Surface Plasmon Resonance / Q000379:methods*
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles; D006046:Gold; D003300:Copper