title: Mammographic surveillance in women aged 35-39 at enhanced familial risk of breast cancer (FH02).
abstract: Although there have been encouraging recent studies showing a potential benefit from annual mammography in women aged 40-49 years of age with an elevated breast cancer risk due to family history there is little evidence of efficacy in women aged <40 years of age. A prospective study (FH02) has been developed to assess the efficacy of mammography screening in women aged 35-39 years of age with a lifetime breast cancer risk of ≥ 17 % who are not receiving MRI screening. Retrospective analyses from five centres with robust recall systems identified 47 breast cancers (n = 12 in situ) with an interval cancer rate of 15/47 (32%). Invasive tumour size, lymph node status and current vital status were all significantly better than in two control groups of unscreened women (including those with a family history) recruited to the POSH study. Further evaluation of the prospective arm of FH02 is required to assess the potential added value of digital mammography and the cancer incidence rates in moderate and high risk women in order to inform cost effectiveness analyses.
authors.affiliation: Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Trust, Wythenshawe, Manchester, M23 9LT, UK, gareth.evans@cmft.nhs.uk.
authors.forename: D G
authors.initials: DG
authors.lastname: Evans
authors.forename: S
authors.initials: S
authors.lastname: Thomas
authors.forename: J
authors.initials: J
authors.lastname: Caunt
authors.forename: L
authors.initials: L
authors.lastname: Roberts
authors.forename: A
authors.initials: A
authors.lastname: Howell
authors.forename: M
authors.initials: M
authors.lastname: Wilson
authors.forename: R
authors.initials: R
authors.lastname: Fox
authors.forename: D M
authors.initials: DM
authors.lastname: Sibbering
authors.forename: S
authors.initials: S
authors.lastname: Moss
authors.forename: M G
authors.initials: MG
authors.lastname: Wallis
authors.forename: D M
authors.initials: DM
authors.lastname: Eccles
authors.forename: S
authors.initials: S
authors.lastname: Duffy
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008327:Mammography; D008403:Mass Screening; D011446:Prospective Studies; D012307:Risk Factors; D006113:United Kingdom