title: A linear optimal transportation framework for quantifying and visualizing variations in sets of images.
abstract: Transportation-based metrics for comparing images have long been applied to analyze images, especially where one can interpret the pixel intensities (or derived quantities) as a distribution of 'mass' that can be transported without strict geometric constraints. Here we describe a new transportation-based framework for analyzing sets of images. More specifically, we describe a new transportation-related distance between pairs of images, which we denote as linear optimal transportation (LOT). The LOT can be used directly on pixel intensities, and is based on a linearized version of the Kantorovich-Wasserstein metric (an optimal transportation distance, as is the earth mover's distance). The new framework is especially well suited for computing all pairwise distances for a large database of images efficiently, and thus it can be used for pattern recognition in sets of images. In addition, the new LOT framework also allows for an isometric linear embedding, greatly facilitating the ability to visualize discriminant information in different classes of images. We demonstrate the application of the framework to several tasks such as discriminating nuclear chromatin patterns in cancer cells, decoding differences in facial expressions, galaxy morphologies, as well as sub cellular protein distributions.
authors.affiliation: Center for Bioimage Informatics, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Dejan
authors.initials: D
authors.lastname: Slepčev
authors.forename: Saurav
authors.initials: S
authors.lastname: Basu
authors.forename: John A
authors.initials: JA
authors.lastname: Ozolek
authors.forename: Gustavo K
authors.initials: GK
authors.lastname: Rohde
keywords: Optimal transportation; linear embedding