title: The serum galactomannan index predicts mortality in hematopoietic stem cell transplant recipients with invasive aspergillosis.
abstract: We examined the relationship between serum and bronchoalveolar lavage (BAL) galactomannan index (GMI) values and mortality in allogeneic hematopoietic cell transplant recipients with invasive pulmonary aspergillosis. Using a clinical sign and symptom-initiated approach, we found that the serum but not the BAL GMI level correlated with 42- and 180-day patient mortality.
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center.
authors.forename: Cynthia E
authors.initials: CE
authors.lastname: Fisher
authors.forename: A Michal
authors.initials: AM
authors.lastname: Stevens
authors.forename: Wendy
authors.initials: W
authors.lastname: Leisenring
authors.forename: Steven A
authors.initials: SA
authors.lastname: Pergam
authors.forename: Michael
authors.initials: M
authors.lastname: Boeckh
authors.forename: Tobias M
authors.initials: TM
authors.lastname: Hohl
mesh_terms: D000328:Adult; D000368:Aged; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D015331:Cohort Studies; D005260:Female; D005690:Galactose / Q000031:analogs & derivatives; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000401:mortality*; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000097:blood / Q000401:mortality*; D053208:Kaplan-Meier Estimate; D008297:Male; D008351:Mannans / Q000097:blood*; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D008351:Mannans; C012990:galactomannan; D005690:Galactose
keywords: Aspergillus; aspergillosis; galactomannan; mortality; transplant