title: [Sterol regulatory element binding protein 1 and its target gene networks].
abstract: Sterol regulatory element binding protein 1 (SREBP-1) is one of the important nuclear transcription factors. SREBP-1 can maintain lipids dynamic equilibrium by regulating the expression of enzymes required for synthesis of endogenous cholesterol, fatty acids, triglycerides and phospholipids. Anomalies of SREBP-1 and its target genes can cause a series of metabolic diseases such as insulin resistance, type Ⅱ diabetes, heart dysfunction, vascular complications and hepatic steatosis. In these years, the development of high-throughput technologies has greatly expanded our knowledge about SREBP-1 target genes and the pattern of transcriptional regulation. Here we reviewed recent research progress of SREBP-1, with a focus on the protein structure, activation process, DNA binding sites and target genes. Most importantly, we showed the transcriptional regulatory networks based on omics datasets, which will contribute to a better understanding of the role of SREBP-1 in lipid metabolism and provide new clues for the treatment of lipid metabolism disorders.
authors.affiliation: Department of Physiology, Medical College of Nanchang University, Nanchang, China. xltangmail@163.com
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Tang
authors.forename: Li-Bin
authors.initials: LB
authors.lastname: Deng
authors.forename: Jia-Ri
authors.initials: JR
authors.lastname: Lin
authors.forename: Wei-Long
authors.initials: WL
authors.lastname: Zhang
authors.forename: Shuang-Mei
authors.initials: SM
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Wei
authors.forename: Pu-Ming
authors.initials: PM
authors.lastname: Mei
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Shang-Dong
authors.initials: SD
authors.lastname: Liang
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D050356:Lipid Metabolism; D051780:Sterol Regulatory Element Binding Protein 1 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D051780:Sterol Regulatory Element Binding Protein 1