title: High-risk human papillomavirus DNA test: could it be useful in low-grade cervical lesion triage? Five-year follow-up.
abstract: We conducted a retrospective, observational study in order to evaluate the role of high-risk human papillomavirus (hrHPV)-DNA test in patients with first diagnosis of low-grade squamous intraepithelial lesions (L-SILs).Patients were divided into group A, annual Papanicolaou test and hrHPV-DNA tests (167 patients) and group B, immediate colposcopy, followed by annual papanicolaou test and hrHPV-DNA tests (164 patients). We assessed sensitivity, specificity, negative predictive value (NPV), positive predictive value, positive-negative likelihood ratio of hrHPV-DNA test, and 5-year relative risk of cervical intraepithelial neoplasia grade 2 in hrHPV-DNA+. Colposcopy is still considered the best choice for women with L-SIL and hrHPV-DNA+ test. High sensitivity and NPV of hrHPV-DNA test permit to use it in the follow-up of L-SIL with a HPV-negative status, without necessity of referring to colposcopy.
authors.affiliation: 1Department of Woman and Child Health, University of Padua, Padua, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Saccardi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gizzo
authors.forename: Marco
authors.initials: M
authors.lastname: Noventa
authors.forename: Omar
authors.initials: O
authors.lastname: Anis
authors.forename: Stefania
authors.initials: S
authors.lastname: Di Gangi
authors.forename: Tito Silvio
authors.initials: TS
authors.lastname: Patrelli
authors.forename: Donato
authors.initials: D
authors.lastname: D'Antona
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Nardelli
mesh_terms: D000328:Adult; D052685:Alphapapillomavirus / Q000235:genetics; D002584:Cervix Uteri / Q000473:pathology* / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D061809:Human Papillomavirus DNA Tests / Q000706:statistics & numerical data* / Q000639:trends; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000235:genetics; D012189:Retrospective Studies; D012307:Risk Factors; D014218:Triage / Q000706:statistics & numerical data* / Q000639:trends
chemical_list: D004279:DNA, Viral
keywords: L-SIL triage; colposcopy; follow-up; hrHPV-DNA test; infection disease; mild dyskaryosis