title: FEM simulation of the die compaction of pharmaceutical products: influence of visco-elastic phenomena and comparison with experiments.
abstract: This work studies the influence of visco-elastic behavior in the finite element method (FEM) modeling of die compaction of pharmaceutical products and how such a visco-elastic behavior may improve the agreement between experimental and simulated compression curves. The modeling of the process was conducted on a pharmaceutical excipient, microcrystalline cellulose (MCC), by using Drucker-Prager cap model coupled with creep behavior in Abaqus(®) software. The experimental data were obtained on a compaction simulator (STYLCAM 200R). The elastic deformation of the press was determined by performing experimental tests on a calibration disk and was introduced in the simulation. Numerical optimization was performed to characterize creep parameters. The use of creep behavior in the simulations clearly improved the agreement between the numerical and experimental compression curves (stresses, thickness), mainly during the unloading part of the compaction cycle. For the first time, it was possible to reproduce numerically the fact that the minimum tablet thickness is not obtained at the maximum compression stress. This study proves that creep behavior must be taken into account when modeling the compaction of pharmaceutical products using FEM methods.
authors.affiliation: Université Paris-Sud, Laboratoire Matériaux et Santé, EA 401, Faculté de pharmacie, 5 rue Jean-Baptiste Clément, 92290 Chatenay-Malabry Cedex, France. harona.diarra@u-psud.fr
authors.forename: Harona
authors.initials: H
authors.lastname: Diarra
authors.forename: Vincent
authors.initials: V
authors.lastname: Mazel
authors.forename: Virginie
authors.initials: V
authors.lastname: Busignies
authors.forename: Pierre
authors.initials: P
authors.lastname: Tchoreloff
mesh_terms: D002482:Cellulose / Q000737:chemistry*; D004548:Elasticity; D005079:Excipients / Q000737:chemistry*; D020342:Finite Element Analysis; D008962:Models, Theoretical; D011208:Powders; D013314:Stress, Mechanical; D013607:Tablets; D014783:Viscosity
chemical_list: D005079:Excipients; D011208:Powders; D013607:Tablets; D002482:Cellulose; C109691:microcrystalline cellulose
keywords: Creep behavior; Die compression; FEM simulation; Pharmaceutical products