title: Effect of intensive lifestyle intervention on sexual dysfunction in women with type 2 diabetes: results from an ancillary Look AHEAD study.
abstract: OBJECTIVE
  Sexual dysfunction is a prevalent problem in obese women with type 2 diabetes. This study examined the effects of intensive lifestyle intervention (ILI) in these women.
  
  
  METHODS
  Look AHEAD is a 16-center, randomized, controlled trial evaluating the health effects of ILI compared with a control group (diabetes support and education [DSE]). The Look AHEAD Sexual Function Ancillary study included 375 female participants at five Look AHEAD sites. Participants completed the Female Sexual Function Inventory (FSFI) and Beck Depression Inventory (BDI), and assessments of weight and cardiovascular risk factors at baseline and 1 year were made.
  
  
  RESULTS
  At baseline, 50% of the 229 participants who reported being sexually active met criteria for female sexual dysfunction (FSD); only BDI score was related to FSD. One-year weight losses were greater in the ILI group than in the DSE group (7.6 vs. 0.45 kg; P<0.001). Among women with FSD at baseline, those in the ILI group (N=60) compared with those in the DSE group (N=53) were significantly more likely to remain sexually active (83 vs. 64%; P<0.008), reported greater improvement in total FSFI scores and in most FSFI domains (P<0.05), and were more likely to experience remission of FSD (28 vs. 11%; P<0.04) at 1 year. No significant differences between ILI and DSE were seen in women who did not have FSD at baseline.
  
  
  CONCLUSIONS
  Participation in ILI appeared to have beneficial effects on sexual functioning among obese women with diabetes, particularly in those who had FSD at baseline.
authors.affiliation: Corresponding author: Rena R. Wing, rwing@lifespan.org.
authors.forename: Rena R
authors.initials: RR
authors.lastname: Wing
authors.forename: Dale S
authors.initials: DS
authors.lastname: Bond
authors.forename: Isaias Noel
authors.initials: IN
authors.lastname: Gendrano
authors.forename: Thomas
authors.initials: T
authors.lastname: Wadden
authors.forename: Judy
authors.initials: J
authors.lastname: Bahnson
authors.forename: Cora E
authors.initials: CE
authors.lastname: Lewis
authors.forename: Frederick
authors.initials: F
authors.lastname: Brancati
authors.forename: Stephen
authors.initials: S
authors.lastname: Schneider
authors.forename: Abbas E
authors.initials: AE
authors.lastname: Kitabchi
authors.forename: Brent
authors.initials: B
authors.lastname: Van Dorsten
authors.forename: Raymond C
authors.initials: RC
authors.lastname: Rosen
mesh_terms: D000368:Aged; D001835:Body Weight / Q000502:physiology; D003863:Depression; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology* / Q000523:psychology* / Q000628:therapy; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D011795:Surveys and Questionnaires; D015431:Weight Loss / Q000502:physiology*