title: Plasma leptin, glucose and non-esterified fatty acid variations in dromedary camels exposed to prolonged periods of underfeeding or dehydration.
abstract: The involvement of plasma leptin in the adaptation of dromedary camels to harsh conditions such as food or water shortages was studied through 2 experiments. In experiment 1, fourteen female camels were either fed at 68% of maintenance energy requirements (MER) during 112d (n=4) or overfed at 134% of MER during the first 56d and then underfed at 17% of MER the next 56d (OV-UN, n=5), or underfed and then overfed for the same durations and energy intake levels (UN-OV, n=5). Weekly plasma samples showed that leptin, glucose and non-esterified fatty acid (NEFA) concentrations were significantly modulated by energy intake level. NEFA increased sharply but transiently in underfed camels of the UN-OV or OV-UN groups, whereas glucose and leptin concentrations decreased with underfeeding and increased with overfeeding with more significant effects in camels that were previously overfed or underfed, respectively. In experiment 2 twelve female camels were either normally watered (n=6) or dehydrated (n=6) during 23d and then rehydrated during 4d. Dehydration specifically increased blood hematocrit, plasma NEFA and glucose whereas leptin decreased slightly. For both experiments, leptinemia was positively related to hump adipocyte volume. Taken together these results provide new data for a better understanding of lipid and energy metabolism in camels.
authors.affiliation: INRA, UMR 1213 Herbivores, F-63122 Saint-Genès Champanelle, France. carole.delavaud@clermont.inra.fr|Clermont Université, VetAgro Sup, UMR1213 Herbivores, BP 10448, F-63000, Clermont-Ferrand, France
authors.forename: Carole
authors.initials: C
authors.lastname: Delavaud
authors.affiliation: FAO Subregional Office for North Africa, BP.300, Cite EL Mahragene, 1082 Tunis, Tunisia
authors.forename: Mohammed
authors.initials: M
authors.lastname: Bengoumi
authors.affiliation: CIRAD-EMVT, TA30/A, Animal Production Programme, Baillarguet, 34398 Montpellier, France
authors.forename: Bernard
authors.initials: B
authors.lastname: Faye
authors.affiliation: INRA, Immunochemistry Unit, F-63122 Saint-Genès Champanelle, France
authors.forename: Didier
authors.initials: D
authors.lastname: Levieux
authors.affiliation: INRA-LRDE, UR045, Quartier Grossetti, F-20250 Corte, France
authors.forename: Sébastien
authors.initials: S
authors.lastname: Grech-Angelini
authors.affiliation: INRA, UMR 1213 Herbivores, F-63122 Saint-Genès Champanelle, France. carole.delavaud@clermont.inra.fr|Clermont Université, VetAgro Sup, UMR1213 Herbivores, BP 10448, F-63000, Clermont-Ferrand, France
authors.forename: Yves
authors.initials: Y
authors.lastname: Chilliard
mesh_terms: D017667:Adipocytes / Q000166:cytology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight; D002162:Camelus / Q000097:blood*; D048429:Cell Size; D003681:Dehydration / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D005508:Food Deprivation; D006400:Hematocrit; D020738:Leptin / Q000097:blood*
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D005230:Fatty Acids, Nonesterified; D020738:Leptin
keywords: Ab; Adiposity; BW; CTRL; Camel; D; Dehydration; EXP; FL; Leptin; MER; NEFA; OV-UN; RIA; UN-OV; Underfeeding; antibody; body weight; control; day; experimental; feeding level; maintenance energy requirement; non-esterified fatty acid; overfed then underfed; radioimmunoassay; underfed then overfed