title: The relationship between metabolism and the autophagy machinery during the innate immune response.
abstract: The innate immune response is shaped by multiple factors, including both traditional autophagy and LC3-associated phagocytosis (LAP). As the autophagic machinery is engaged during times of nutrient stress, arising from scarcity or pathogens, we examine how autophagy, specifically LAP, and cellular metabolism together influence macrophage function and the innate immune response.
authors.affiliation: Department of Immunology, St. Jude Children's Research Institute, Memphis, TN 38105, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Martinez
authors.affiliation: Department of Immunology, St. Jude Children's Research Institute, Memphis, TN 38105, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Verbist
authors.affiliation: Department of Immunology, St. Jude Children's Research Institute, Memphis, TN 38105, USA.
authors.forename: Ruoning
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Immunology, St. Jude Children's Research Institute, Memphis, TN 38105, USA. Electronic address: douglas.green@stjude.org.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Green
mesh_terms: D001343:Autophagy / Q000276:immunology*; D004734:Energy Metabolism; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000276:immunology / Q000378:metabolism*; D010587:Phagocytosis / Q000276:immunology*; D010588:Phagosomes / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology
chemical_list: C477012:MAP1LC3A protein, human; D008869:Microtubule-Associated Proteins