title: Parallel improvement of left ventricular geometry and filling pressure after transcatheter aortic valve implantation in high risk aortic stenosis: comparison with major prosthetic surgery by standard echo Doppler evaluation.
abstract: OBJECTIVE
  The effect of Transcatheter Aortic Valve Implantation (TAVI) on left ventricular (LV) geometry and function was compared to traditional aortic replacement (AVR) by major surgery.
  
  
  METHODS
  45 patients with aortic stenosis (AS) undergoing TAVI and 33 AVR were assessed by standard echo Doppler the day before and 2 months after the implantation. 2D echocardiograms were performed to measure left ventricular (LV) mass index (LVMi), relative wall thickness (RWT), ejection fraction (EF) and the ratio between transmitral E velocity and early diastolic velocity of mitral annulus (E/e' ratio). Valvular-arterial impedance (Zva) was also calculated.
  
  
  RESULTS
  At baseline, the 2 groups were comparable for blood pressure, heart rate, body mass index mean transvalvular gradient and aortic valve area. TAVI patients were older (p<0.0001) and had greater LVMi (p<0.005) than AVR group. After 2 months, both the procedures induced a significant reduction of transvalvular gradient and Zva but the decrease of LVMi and RWT was significant greater after TAVI (both p<0.0001). E/e' ratio and EF were significantly improved after both the procedure but E/e' reduction was greater after TAVI (p<0.0001). TAVI exhibited greater percent reduction in mean transvalvular gradient (p<0.05), Zva (p<0.02), LVMi (p<0.0001), RWT (p<0.0001) and E/e' ratio (p<0.0001) than AVR patients. Reduction of E/e' ratio was positively related with reduction of RWT (r = 0.46, p<0.002) only in TAVI group, even after adjusting for age and percent reduction of Zva (r =0.43, p<0.005).
  
  
  CONCLUSIONS
  TAVI induces a greater improvement of estimated LV filling pressure in comparison with major prosthetic surgery, due to more pronounced recovery of LV geometry, independent on age and changes of hemodynamic load.
authors.affiliation: Division of Cardiology, San Carlo Hospital, Potenza, Italy.
authors.forename: Marco Fabio
authors.initials: MF
authors.lastname: Costantino
authors.forename: Maurizio
authors.initials: M
authors.lastname: Galderisi
authors.forename: Ernesta
authors.initials: E
authors.lastname: Dores
authors.forename: Pasquale
authors.initials: P
authors.lastname: Innelli
authors.forename: Giandomenico
authors.initials: G
authors.lastname: Tarsia
authors.forename: Maurilio
authors.initials: M
authors.lastname: Di Natale
authors.forename: Ciro
authors.initials: C
authors.lastname: Santoro
authors.forename: Francesco
authors.initials: F
authors.lastname: De Stefano
authors.forename: Roberta
authors.initials: R
authors.lastname: Esposito
authors.forename: Giovanni
authors.initials: G
authors.lastname: de Simone
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000601:surgery*; D001794:Blood Pressure; D006328:Cardiac Catheterization / Q000706:statistics & numerical data*; D015897:Comorbidity; D015150:Echocardiography, Doppler / Q000706:statistics & numerical data*; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000706:statistics & numerical data*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000517:prevention & control*