title: Status ofLEPRGene in PCB-exposed Population: A Quick Look.
abstract: Earlier, we have reported that Polychlorinated Biphenyls (PCBs) exposure in Slovak population has made differential gene expression that has linked to the possibilities of some diseases and disorder development in the studied population. Here we report that down-regulation of LEPR (Leptin receptor) gene in the 45-month children may have been following consequences in developing obesity later in life. A pilot high-throughput qRT-PCR [Taqman Low Density Array (TLDA)] study in a small population also corroborated the gene-expression results, and their pathways underlying the consequences of the diseases, amid further detailed large-scale population validation. The study shows the opportunity of predicting long-term effects of chemical exposures using selected genomic classifiers may reflect exposure effect and risk from environmental toxicants.
authors.affiliation: Department of Biology, Howard University, Washington DC, USA.
authors.forename: Somiranjan
authors.initials: S
authors.lastname: Ghosh
authors.forename: Tomas
authors.initials: T
authors.lastname: Trnovec
authors.forename: Lubica
authors.initials: L
authors.lastname: Palkovicova
authors.forename: Eric P
authors.initials: EP
authors.lastname: Hoffman
authors.forename: Kareem
authors.initials: K
authors.lastname: Washington
authors.forename: Sisir K
authors.initials: SK
authors.lastname: Dutta
keywords: Gene Expression; Leptin Receptor; Obesity; PCBs