title: Over the scope clip: technique and expanding clinical applications.
abstract: BACKGROUND
  Advances in endoscopic and surgical techniques have increased the frequency and complexity of these procedures, and thus, the incidence of associated complications.
  
  
  OBJECTIVE
  To describe the use and clinical applications of the Over the Scope Clip (OTSC) system.
  
  
  METHODS
  An English language literature search was conducted using the key words "endoscopy" and "over the scope clip" in order to identify human studies evaluating the application of OTSC from January 2001 to August 2012. The indication, efficacy, complications, and limitations were recorded.
  
  
  RESULTS
  Overall success rates of OTSC based on current literature range are in the range of 75% to 100% for closure of iatrogenic gastrointestinal perforations, 38% to 100% for closure of gastrointestinal fistulas, 50% to 100% for anastomotic leaks, and 71% to 100% for bleeding lesions. OTSCs have shown 100% success rates in managing postbariatric surgery weight gain secondary to dilation of the gastrojejunal pouch.
  
  
  CONCLUSIONS
  OTSC is easy to use with good results, thus decreasing the morbidity and mortality associated with the complications secondary to both diagnostic and therapeutic endoscopy and avoiding surgery in many situations.
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, The Brooklyn Hospital Center, New York Presbyterian Healthcare System, Weill Cornell Medical College, Brooklyn, NY.
authors.forename: Shashideep
authors.initials: S
authors.lastname: Singhal
authors.forename: Kinesh
authors.initials: K
authors.lastname: Changela
authors.forename: Haris
authors.initials: H
authors.lastname: Papafragkakis
authors.forename: Sury
authors.initials: S
authors.lastname: Anand
authors.forename: Mahesh
authors.initials: M
authors.lastname: Krishnaiah
authors.forename: Sushil
authors.initials: S
authors.lastname: Duddempudi
mesh_terms: D020776:Endoscopes, Gastrointestinal; D016099:Endoscopy, Gastrointestinal / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D011183:Postoperative Complications / Q000453:epidemiology; D016896:Treatment Outcome