title: Guillain-Barre syndrome as a paraneoplastic manifestation of disseminated squamous cell carcinoma.
abstract: We describe a 65-year-old woman who developed ascending, symmetrical paraesthesia and weakness. This was on a background of metastatic disseminated squamous cell carcinoma, with a likely recurrent mandibular primary. Serum testing for antiganglioside antibodies was strongly positive. Despite a 5-day course of intravenous immunoglobulin, the patient passed away on day 34 of admission. This is the first case, to our knowledge, of Guillain-Barré syndrome in association with squamous cell carcimoma.
authors.affiliation: Department of Infectious Diseases, Brighton and Sussex University Hospitals, Brighton, UK. vishalnavani@googlemail.com
authors.forename: Vishal
authors.initials: V
authors.lastname: Navani
authors.forename: Daniel
authors.initials: D
authors.lastname: Webster
authors.forename: Sion K
authors.initials: SK
authors.lastname: Williams
authors.forename: Daniel
authors.initials: D
authors.lastname: Agranoff
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D049268:Positron-Emission Tomography
chemical_list: D016756:Immunoglobulins, Intravenous