title: The genetic polymorphisms of cathepsin S were associated with metabolic disorders in a Chinese Han population.
abstract: Cathepsin S (CTSS) played an important role in the etiology of cardiovascular disease and metabolic syndrome. Few studies had been reported on the association between the polymorphisms of CTSS and metabolic disorders in Asian population. Therefore we explored the association between the polymorphisms of CTSS and metabolic disorders in a Chinese Han population. The subjects were a Chinese Han cohort with 1160 participants, and the genotyping was performed with PCR-RFLP. Polymorphism rs16827671 was associated with BMI and serum total cholesterol (P=0.001; P=0.02, respectively). Subjects with CT genotype of rs16827671 had a higher risk of hypercholesterolemia (OR=1.64, 95% CI: 1.15-2.33, P=0.006) compared with TT genotype. Subjects with AG genotype of rs11576175 had lower risks of hypertriglyceridemia and borderline hypercholesterolemia (OR=0.52, 95% CI: 0.36-0.73, P=0.0001; OR=0.52, 95% CI: 0.35-0.77, P=0.001, respectively) compared with GG genotype. Compared with the haplotype TG, haplotype TA had a lower risk of hypertriglyceridemia and a higher risk of borderline hypercholesterolemia (OR=0.62, 95% CI: 0.44-0.88, P=0.002; OR=1.59, 95% CI: 1.10-2.31, P=0.008, respectively), and haplotype CA had a lower risk of hypercholesterolemia (OR=0.35, 95% CI: 0.18-0.68, P=0.002). In conclusion, we found that the genetic polymorphisms of CTSS were associated with metabolic disorders in a Chinese Han population, which would enrich the knowledge on genetic mechanisms of the pathogenesis of metabolic disorders.
authors.affiliation: Department of Occupational Health and Occupational Medicine, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China.
authors.forename: Zejin
authors.initials: Z
authors.lastname: Ou
authors.forename: Guanghai
authors.initials: G
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Zuliang
authors.initials: Z
authors.lastname: Ma
authors.forename: Danmiao
authors.initials: D
authors.lastname: Lin
authors.forename: Meng
authors.initials: M
authors.lastname: Dai
authors.forename: Fei
authors.initials: F
authors.lastname: Zou
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002403:Cathepsins / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult
chemical_list: D002403:Cathepsins; C028217:cathepsin S
keywords: Association study; BMI; CI; CTSS; Dyslipidemia; ECM; GWAS; HDL; HWE; Hardy–Weinberg equilibrium; NCEP-ATP III; National Cholesterol Education Program Adult Treatment Panel III; OR; Obesity; PCR-RFLP; TC; TG; body mass index; cathepsin S; confidence interval; extracellular matrix; genome-wide association study; high-density lipoprotein; odds ratio; polymerase chain reaction-restriction fragment length polymorphism; total cholesterol; triglyceride