title: (18)F-FDG PET/CT for Diagnosis of Osteosclerotic and Osteolytic Vertebral Metastatic Lesions: Comparison with Bone Scintigraphy.
abstract: METHODS
  A retrospective study.
  
  
  OBJECTIVE
  The aims of this study were to investigate the diagnostic value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in PET/computed tomography (CT) in the evaluation of spinal metastatic lesions.
  
  
  BACKGROUND
  Recent studies described limitations regarding how many lesions with abnormal (18)F-FDG PET findings in the bone show corresponding morphologic abnormalities.
  
  
  METHODS
  The subjects for this retrospective study were 227 patients with primary malignant tumors, who were suspected of having spinal metastases. They underwent combined whole-body (18)F-FDG PET/CT scanning for evaluation of known neoplasms in the whole spine. (99m)Tc-methylene diphosphonate bone scan was performed within 2 weeks following PET/CT examinations. The final diagnosis of spinal metastasis was established by histopathological examination regarding bone biopsy or magnetic resonance imaging (MRI) findings, and follow-up MRI, CT and (18)F-FDG PET for extensively wide lesions with subsequent progression.
  
  
  RESULTS
  From a total of 504 spinal lesions in 227 patients, 224 lesions showed discordant image findings. For 122 metastatic lesions with confirmed diagnosis, the sensitivity/specificity of bone scan and FDG PET were 84%/21% and 89%/76%, respectively. In 102 true-positive metastatic lesions, the bone scan depicted predominantly osteosclerotic changes in 36% and osteolytic changes in 19%. In 109 true-positive lesions of FDG PET, osteolytic changes were depicted predominantly in 38% while osteosclerotic changes were portrayed in 15%.
  
  
  CONCLUSIONS
  (18)F-FDG PET in PET/CT could be used as a substitute for bone scan in the evaluation of spinal metastasis, especially for patients with spinal osteolytic lesions on CT.
authors.affiliation: Departments of Orthopaedics and Rehabilitation Medicine, University of Fukui, Fukui, Japan.
authors.forename: Kenzo
authors.initials: K
authors.lastname: Uchida
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nakajima
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Tsuchida
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hirai
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sugita
authors.forename: Shuji
authors.initials: S
authors.lastname: Watanabe
authors.forename: Naoto
authors.initials: N
authors.lastname: Takeura
authors.forename: Ai
authors.initials: A
authors.lastname: Yoshida
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Okazawa
authors.forename: Hisatoshi
authors.initials: H
authors.lastname: Baba
keywords: 18F-fluorodeoxyglucose positron emission tomography; Metastasis; Positron emission tomography and computed tomography; Spine; Technetium Tc 99m (Sn)methylenediphosphonate