title: [Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report].
abstract: BACKGROUND
  Gout is a metabolic disease by deposition of uric acid crystals, which undertakes joint and soft tissue in both acute and chronic stages. Is a rare event the onset of a tumor in the site of the lesion.
  
  
  OBJECTIVE
  To present a rare case of association between sarcoma and tophi.
  
  
  METHODS
  83 year old man who consulted for tumor in his left elbow about 40 years of evolution, which spontaneously started to hurt. With the presumptive diagnosis of tophi treated surgically. The lesion recurred after 60 days, reintervention and radiotherapy was performed for diagnosis of malignant mesenchymal tumor associated with tophi. At 10 months developed ipsilateral nodal metastases, died within 2 years of the initial consultation.
  
  
  RESULTS
  The diagnosis of the first material resected was tophi. In the reintervention material was diagnosed mesenchymal spindle cell high grade neoplasm associated with tophi; immunohistochemistry revealed: vimentin + / +, MYO D1 - / - ASMA - / -, FVIII - / -, A1ATT - / -, CD68-/ -, S100-/ - with final diagnosis the undifferentiated high grade pleomorphic sarcoma.
  
  
  CONCLUSIONS
  It is uncommon for gouty tophi are associated with other diseases and even fewer do so to tumors. In the literature have reported three previous cases concurrent with neoplasms, which were angiosarcoma, giant cell tumor and malignant fibrous histiocytoma. The latter have a high tendency to recur locally and have ability to distant metastases, especially lung and regional lymph nodes.
authors.forename: Susana
authors.initials: S
authors.lastname: Szlabi
authors.forename: Jorge O
authors.initials: JO
authors.lastname: Flores
authors.forename: Ana L de
authors.initials: AL
authors.lastname: Diller
authors.forename: Marta
authors.initials: M
authors.lastname: Cabrera
mesh_terms: D000369:Aged, 80 and over; D004551:Elbow Joint; D017809:Fatal Outcome; D006073:Gout / Q000150:complications* / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D012509:Sarcoma / Q000150:complications* / Q000473:pathology