title: Perineural spread of cervical cancer to the sciatic nerve.
abstract: In this report we present a patient with a recent diagnosis of cervical adenocarcinoma with progressive left lower extremity pain and weakness. MR imaging of the pelvis and subsequent FDG CT/PET were complementary in demonstrating abnormalities worrisome for perineural spread of malignancy, which was confirmed with an open fascicular biopsy of the sciatic nerve. We review the imaging and propose a mechanism of perineural spread to the sciatic nerve, which we believe is supported by the imaging in this case.
authors.affiliation: Department of Radiology, Mayo Clinic, Charlton 2-290, 200 First Street SW, Rochester, MN, 55905, USA, howe.benjamin@mayo.edu.
authors.forename: Benjamin Matthew
authors.initials: BM
authors.lastname: Howe
authors.forename: Kimberly K
authors.initials: KK
authors.lastname: Amrami
authors.forename: Mark A
authors.initials: MA
authors.lastname: Nathan
authors.forename: Joaquin J
authors.initials: JJ
authors.lastname: Garcia
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Spinner
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D009361:Neoplasm Invasiveness; D010524:Peripheral Nervous System Neoplasms / Q000473:pathology*; D019275:Radiopharmaceuticals; D035583:Rare Diseases / Q000473:pathology; D020426:Sciatic Neuropathy / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18