title: A prospective photographic study of the ocular fundus in obstructive sleep apnea.
abstract: BACKGROUND
  The prevalence of optic nerve and retinal vascular changes within the obstructive sleep apnea (OSA) population are not well-known, although it has been postulated that optic nerve ischemic changes and findings related to an elevated intracranial pressure may be more common in OSA patients. We prospectively evaluated the ocular fundus in unselected patients undergoing overnight diagnostic polysomnography (PSG).
  
  
  METHODS
  Demographic data, medical/ocular history, and nonmydriatic fundus photographs were prospectively collected in patients undergoing PSG at our institution and reviewed for the presence of optic disc edema for which our study was appropriately powered a priori. Retinal vascular changes were also evaluated. OSA was defined using the measures of both sleep-disordered breathing and hypoxia.
  
  
  RESULTS
  Of 250 patients evaluated in the sleep center, fundus photographs were performed on 215 patients, among whom 127 patients (59%) had an apnea/hypopnea index (AHI) ≥ 15 events per hour, including 36 with severe OSA. Those with AHI <15 served as the comparison group. None of the patients had optic disc edema (95% confidence interval [CI]: 0%-3%). There was no difference in rates of glaucomatous appearance or pallor of the optic disc among the groups. Retinal arteriolar changes were more common in severe OSA patients (odds ratio: 1.09 per 5 unit increase in AHI; 95% CI, 1.02-1.16; P = 0.01), even after controlling for mean arterial blood pressure.
  
  
  CONCLUSIONS
  We did not find an increased prevalence of optic disc edema or other optic neuropathies in our OSA population. However, retinal vascular changes were more common in patients with severe OSA, independent of blood pressure.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Clare L
authors.initials: CL
authors.lastname: Fraser
authors.forename: Donald L
authors.initials: DL
authors.lastname: Bliwise
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Newman
authors.forename: Cédric
authors.initials: C
authors.lastname: Lamirel
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Collop
authors.forename: David B
authors.initials: DB
authors.lastname: Rye
authors.forename: Lynn Marie
authors.initials: LM
authors.lastname: Trotti
authors.forename: Valérie
authors.initials: V
authors.lastname: Biousse
authors.forename: Beau B
authors.initials: BB
authors.lastname: Bruce
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D010211:Papilledema / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D017286:Polysomnography; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology