title: [Nitrous oxide - oxygen analgesia in aesthetic dermatology].
abstract: BACKGROUND
  Local anaesthesia often is insufficient for more extensive procedures. Instead of general anaesthesia or sedation, pediatricians, gynaecologists and dentists increasingly use nitrous oxide (N2O). This study evaluates the suitability of this form of anesthesia in dermatology.
  
  
  METHODS
  In 24 patients (18 w, 6 m, mean age 49 y.) N2O/O2 inhalation (Livopan®) was used during 46 procedures with indications including fractional RF/wrinkle reduction, IPL/rosacea, q-sw. laser/tattoos and hemosiderosis as well as fractional Er:Glass laser for scars and hypopigmentation. In 26 procedures subjective pain intensity was measured (visual analogue scale 0-10).
  
  
  RESULTS
  With N2O the treatment pain was lowered from 6.6 ± 1.6 to 2.9 ± 1.7 (median, p = 0.000). 23/24 patients chose N2O for their next treatment. Beside euphoria, fatigue, slight drowsiness, dizziness, nausea or change in auditory perception, no other side effects occurred.
  
  
  CONCLUSIONS
  The pronounced analgesia, the easy self-administration, the fast onset and complete recovery after a few minutes and the low ratio of side effects make the N2O/O2 inhalation to an ideal addendum in the management of larger painful procedures in dermatology as long as contraindications and safety precautions are respected.
authors.affiliation: Hautarzt, Allergologe, Phlebologe, Haut & Laser Schwerin, Bischofstr. 11, 19055 Schwerin, Deutschland. info@hlzs.de
authors.forename: M
authors.initials: M
authors.lastname: Drosner
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D062109:Dermatologic Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D009609:Nitrous Oxide / Q000008:administration & dosage*; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D010149:Postoperative Pain / Q000209:etiology* / Q000517:prevention & control*; D019651:Plastic Surgery Procedures / Q000009:adverse effects* / Q000379:methods; D012646:Self Administration / Q000379:methods; D016896:Treatment Outcome
chemical_list: D018685:Anesthetics, Inhalation; D009609:Nitrous Oxide