title: Lipoprotein-associated phospholipase A2 and venous thromboembolism: a prospective study.
abstract: BACKGROUND
  Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory marker associated positively with atherothrombotic risk. Whether Lp-PLA2 is related to risk of venous thromboembolism (VTE) is incompletely studied.
  
  
  METHODS
  We assessed Lp-PLA2 activity in 10,687 Atherosclerosis Risk in Communities (ARIC) Study participants and followed them a median of 8.3 years (from 1996-98 through 2005) for VTE occurrence (n=226).
  
  
  RESULTS
  There was no significant association between baseline Lp-PLA2 quartiles and risk of VTE, neither overall nor stratified as provoked or unprovoked. Adjusted for other risk factors, the hazard ratios (95% confidence interval) of total VTE across quartiles of Lp-PLA2 were 1.0 (reference), 0.95 (0.64, 1.42), 1.03 (0.69, 1.56), and 1.26 (0.83, 1.91). In the subset of participants with LDL-cholesterol ≥130 mg/dL, hazard ratios of total VTE were 1.00, 1.39 (0.44, 4.44), 2.45 (0.84, 7.11), and 2.84 (0.99, 8.14).
  
  
  CONCLUSIONS
  Our study does not support the overall hypothesis that elevated Lp-PLA2 contributes to VTE occurrence in the general population. However, in the presence of high LDL-cholesterol there was some evidence that Lp-PLA2 may increase VTE risk.
authors.affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA. folso001@umn.edu
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Folsom
authors.forename: Pamela L
authors.initials: PL
authors.lastname: Lutsey
authors.forename: Nicholas S
authors.initials: NS
authors.lastname: Roetker
authors.forename: Christie M
authors.initials: CM
authors.lastname: Ballantyne
authors.forename: Ron C
authors.initials: RC
authors.lastname: Hoogeveen
authors.forename: Wayne D
authors.initials: WD
authors.lastname: Rosamond
authors.forename: Mary
authors.initials: M
authors.lastname: Cushman
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood* / Q000378:metabolism; D000368:Aged; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000097:blood* / Q000201:enzymology* / Q000209:etiology
chemical_list: D008078:Cholesterol, LDL; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase
keywords: ARIC; Atherosclerosis Risk in Communities; C-reactive protein; CI; CRP; LDL; Lipoprotein-associated phospholipase A(2); Lp-PLA(2); Prospective study; Pulmonary embolism; SD; VTE; Venous thromboembolism; aPTT; activated partial thromboplastin time; confidence interval; eGFR; estimate glomerular filtration rate; low-density lipoprotein; plasma lipoprotein-associated phospholipase A(2); standard deviation; venous thromboembolism