title: Asymmetric sensory ganglionopathy: a case series.
abstract: BACKGROUND
  Sensory ganglionopathies are uncommon but potentially very disabling. They have heterogeneous etiologies including autoimmune, paraneoplastic, toxic, and inflammatory although many remain idiopathic despite intensive investigation. Asymmetric sensory loss is relatively common at the onset, but with time, symptoms usually spread to involve all limbs symmetrically.
  
  
  METHODS
  We report 6 patients with a persistent strikingly asymmetrical sensory ganglionopathy with acute or subacute onset and slow progression.
  
  
  RESULTS
  Peripheral nerve biopsies in 5 patients showed axonal loss without significant inflammation; a dorsal root ganglion biopsy in 1 patient showed neuronal loss and inflammatory infiltrate. Four patients received immunomodulatory treatment, but overall the response to treatment was poor.
  
  
  CONCLUSIONS
  Asymmetrical sensory ganglionopathies may have an inflammatory basis. Immunomodulatory therapy may be considered early in the disease course, although in this series there was a limited response to treatment.
authors.affiliation: Servicio de Neurologia, Hospital Universitario Virgen del Rocío, Seville, Spain.
authors.forename: Celedonio
authors.initials: C
authors.lastname: Marquez-Infante
authors.forename: Sinéad M
authors.initials: SM
authors.lastname: Murphy
authors.forename: Liberty
authors.initials: L
authors.lastname: Mathew
authors.forename: Ali
authors.initials: A
authors.lastname: Alsanousi
authors.forename: Michael P
authors.initials: MP
authors.lastname: Lunn
authors.forename: Sebastian
authors.initials: S
authors.lastname: Brandner
authors.forename: Tarek A
authors.initials: TA
authors.lastname: Yousry
authors.forename: Julian
authors.initials: J
authors.lastname: Blake
authors.forename: Mary M
authors.initials: MM
authors.lastname: Reilly
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005727:Ganglia, Spinal / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000175:diagnosis* / Q000503:physiopathology*