title: The association between estrogen receptor alpha polymorphisms and the risk of prostate cancer in Slovak population.
abstract: The aim of our study was to evaluate the effect of two polymorphisms in the estrogen receptor alpha, PvuII and XbaI, on the development of prostate cancer within Slovak population, as well as their correlation with selected clinical characteristics. The study was performed using 311 prostate cancer patients and 256 healthy male controls. Both polymorphisms were significantly associated with higher risk of prostate cancer development. At the same time, the CC genotype of PvuII polymorphism (OR = 1.98; 95% CI 0.94-4.21; p = 0.05) and the AG genotype of XbaI polymorphism (OR = 1.74; 95% CI 1.0-3.02; p = 0.04) significantly contributed to the development of low-grade carcinoma, while the AG and GG genotypes of the XbaI polymorphism contributed mainly to the development of high-grade prostate cancer (OR = 1.83; 95% CI 1.12-3.01; p = 0.01 and OR = 2.13; 95% CI 1.06-4.19; p = 0.03, respectively). Similarly, the AG and GG genotypes of XbaI polymorphism showed significant association with prostate cancer in patients with serum PSA level ≥10 ng/ml. Both polymorphisms were found at the same time to be more frequent in patients diagnosed before the age of 60. We conclude on the basis of these results that PvuII and XbaI polymorphisms of estrogen receptor alpha might be associated with prostate cancer risk within Slovak population. Although this is a pilot study and, as such, more detailed investigations are needed to confirm the role of these polymorphisms in prostate cancer development and progression within said Slovak population, our results might still provide a valuable basis for further research with larger patient groups.
authors.affiliation: Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic. jurecekova@jfmed.uniba.sk
authors.forename: Jana
authors.initials: J
authors.lastname: Jurečeková
authors.forename: Monika Kmetová
authors.initials: MK
authors.lastname: Sivoňová
authors.forename: Andrea
authors.initials: A
authors.lastname: Evinová
authors.forename: Ján
authors.initials: J
authors.lastname: Kliment
authors.forename: Dušan
authors.initials: D
authors.lastname: Dobrota
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000235:genetics*; D012307:Risk Factors; D018154:Slovakia
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D017430:Prostate-Specific Antigen