title: Role of T cells in the modulation of PTH action: physiological and clinical significance.
abstract: Osteoimmunology is new field of research dedicated to the study of the interactions between the immune system and bone. Among the cells of the immune system that regulate bone and hemopoietic cells are T lymphocytes. These cells secrete osteoclastogenic cytokines such as RANKL and TNF, as well as factors that stimulate bone formation and hemopoietic cells, one of which is Wnt10b. This article will review the evidence that T cells are implicated in the mechanism of action of parathyroid hormone (PTH) in bone and on the hemopoietic system.
authors.affiliation: Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle, Room 1309, Atlanta, GA, 30322, USA, roberto.pacifici@emory.edu.
authors.forename: Roberto
authors.initials: R
authors.lastname: Pacifici
mesh_terms: D001842:Bone and Bones / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000502:physiology*; D010012:Osteogenesis / Q000276:immunology / Q000502:physiology*; D010281:Parathyroid Hormone / Q000502:physiology*; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D016207:Cytokines; D010281:Parathyroid Hormone