title: Topiramate-induced angle-closure glaucoma: cross-sensitivity with other sulphonamide derivatives causing anterior uveitis.
abstract: Topiramate is a recognized cause of drug-induced acute angle-closure glaucoma. We describe a case presenting with bilateral acute angle-closure glaucoma caused by topiramate intake. Patient subsequently developed severe anterior uveitis caused by sulphonamide derivatives (acetazolamide and co-trimoxazole) due to cross-sensitivity, on two separate occasions. The present case also highlights the role of anterior segment optical tomography in diagnosis and follow-up. In a patient with known drug allergy to topiramate, other sulphonamide derivatives should be avoided to limit the ocular morbidity.
authors.affiliation: Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, 110002, India, drskamal@gmail.com.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Kamal
authors.forename: Usha
authors.initials: U
authors.lastname: Yadava
authors.forename: Sushil
authors.initials: S
authors.lastname: Kumar
authors.forename: Ruchi
authors.initials: R
authors.lastname: Goel
mesh_terms: D000328:Adult; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D015812:Glaucoma, Angle-Closure / Q000139:chemically induced*; D006801:Humans; D018696:Neuroprotective Agents / Q000009:adverse effects*; D013449:Sulfonamides / Q000009:adverse effects*; D000077236:Topiramate; D014606:Uveitis, Anterior / Q000139:chemically induced*
chemical_list: D018696:Neuroprotective Agents; D013449:Sulfonamides; D000077236:Topiramate; D005632:Fructose