title: Spectrophotometric sequential injection determination of D-penicillamine based on a complexation reaction with nickel ion.
abstract: A simple and sensitive spectrophotometric method, based on reaction between Ni(II) ion and D-penicillamine (PEN), was developed. The proposed SIA system enhanced the analytical applicability of the reaction of complexation, and allowed the determination of PEN in the concentration range of 3.0 × 10(-6) - 2.0 × 10(-4) mol L(-1) with a sampling rate of 200 h(-1). With the proposed SIA system, PEN could be accurately determinated up to 0.9 nmol quantity. The method was successfully applied to the determination of PEN in laboratory samples and pharmaceuticals.
authors.affiliation: Department of Chemistry, Faculty of Science and Education, University of Mostar, Bosnia and Herzegovina. anita.martinovic@fpmoz.ba
authors.forename: Anita
authors.initials: A
authors.lastname: Martinović-Bevanda
authors.forename: Njegomir
authors.initials: N
authors.lastname: Radić
mesh_terms: D002626:Chemistry, Pharmaceutical; D057230:Limit of Detection; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000032:analysis* / Q000737:chemistry; D010396:Penicillamine / Q000032:analysis* / Q000737:chemistry; D013053:Spectrophotometry
chemical_list: D009942:Organometallic Compounds; D009532:Nickel; D010396:Penicillamine