title: Oxidative stress and neurodegeneration: the yeast model system.
abstract: In this chapter we are treating yeast cells as a model for oxidative stress response and the consequences of oxidative stress which are one cause for a number of human diseases, including neurodegenerative diseases, which form the main part of this paper. All such model building depends on orthologous relations between highly conserved yeast and human genes, which are easily recognized by sequence comparisons, but much more difficult to prove functionally. Previously we have treated Friedreich's ataxia, while presently we are describing in detail the neuronal ceroid lipofuscinoses, among them Batten disease. A general overview is given how yeast can aid current research in three of the most devastating and at the same time quantitatively most important neurodegenerative diseases of old age: Alzheimer's, Huntington's, and Parkinson's disease. In the ensuing part of the chapter, we describe yeast as model for metabolic regulation and hence as a model for inborn errors of metabolism that are in some instances very faithfully mirrored by introducing the same point mutations into yeast cells which are known from patients.
authors.affiliation: Department of Cell Biology, Divison of Genetics, University of Salzburg, 5020 Salzburg, Austria. michael.breitenbach@sbg.ac.at
authors.forename: Michael
authors.initials: M
authors.lastname: Breitenbach
authors.forename: Markus
authors.initials: M
authors.lastname: Ralser
authors.forename: Gabriel G
authors.initials: GG
authors.lastname: Perrone
authors.forename: Bernhard
authors.initials: B
authors.lastname: Iglseder
authors.forename: Mark
authors.initials: M
authors.lastname: Rinnerthaler
authors.forename: Ian W
authors.initials: IW
authors.lastname: Dawes
mesh_terms: D006801:Humans; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D018384:Oxidative Stress; D010427:Pentose Phosphate Pathway; D012441:Saccharomyces cerevisiae / Q000378:metabolism*