title: TRP channels.
abstract: TRP channels constitute a large superfamily of cation channel forming proteins, all related to the gene product of the transient receptor potential (trp) locus in Drosophila. In mammals, 28 different TRP channel genes have been identified, which exhibit a large variety of functional properties and play diverse cellular and physiological roles. In this article, we provide a brief and systematic summary of expression, function, and (patho)physiological role of the mammalian TRP channels.
authors.affiliation: Laboratory Ion Channel Research and TRP Research Platform Leuven (TRPLe), KU Leuven, Campus Gasthuisberg, Leuven, Belgium.
authors.forename: Maarten
authors.initials: M
authors.lastname: Gees
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Owsianik
authors.forename: Bernd
authors.initials: B
authors.lastname: Nilius
authors.forename: Thomas
authors.initials: T
authors.lastname: Voets
mesh_terms: D000818:Animals; D053447:Channelopathies / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D050053:TRPM Cation Channels / Q000235:genetics / Q000502:physiology; D050051:Transient Receptor Potential Channels / Q000235:genetics / Q000502:physiology*
chemical_list: D050053:TRPM Cation Channels; D050051:Transient Receptor Potential Channels