title: [Major therapeutic advances and new perspectives in onco-hematology].
abstract: Hematology Oncology has a rich history including few crucial therapeutic innovations. These were possible because of the evolution of the cell and molecular biology allowing a better understanding of basic mechanisms of cancerogenesis. We propose here to summarize the most important therapeutic innovations since the beginning of Hematology/Oncology history. We also describe evolution of therapeutic strategies themselves. New insights and therapeutic perspectives for next future are also discussed.
authors.affiliation: CHU Clermont-Ferrand, service d'hématologie clinique adulte et de thérapie cellulaire, 1, place Lucie-Aubrac, 63003 Clermont-Ferrand cedex 01, France. jobay@chu-clermontferrand.fr
authors.forename: Jacques-Olivier
authors.initials: JO
authors.lastname: Bay
authors.forename: Romain
authors.initials: R
authors.lastname: Guièze
authors.forename: Aurélie
authors.initials: A
authors.lastname: Ravinet
authors.forename: Richard
authors.initials: R
authors.lastname: Lemal
authors.forename: Aliénor
authors.initials: A
authors.lastname: Xhaard
authors.forename: Sébastien
authors.initials: S
authors.lastname: Bailly
authors.forename: Cécile
authors.initials: C
authors.lastname: Moluçon-Chabrot
authors.forename: Eric
authors.initials: E
authors.lastname: Hermet
authors.forename: Julian
authors.initials: J
authors.lastname: Biau
authors.forename: Pierre
authors.initials: P
authors.lastname: Verrelle
authors.forename: Régis
authors.initials: R
authors.lastname: Peffault de Latour
authors.forename: Olivier
authors.initials: O
authors.lastname: Tournilhac
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000932:Antiemetics / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D019337:Hematologic Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D006405:Hematology / Q000639:trends*; D018380:Hematopoietic Stem Cell Transplantation / Q000639:trends; D006801:Humans; D008495:Medical Oncology / Q000639:trends*; D058990:Molecular Targeted Therapy / Q000639:trends; D011878:Radiotherapy / Q000639:trends; D011879:Radiotherapy Dosage; D016184:Receptors, Colony-Stimulating Factor / Q000627:therapeutic use; D059016:Tumor Microenvironment
chemical_list: D000900:Anti-Bacterial Agents; D000932:Antiemetics; D000970:Antineoplastic Agents; D016184:Receptors, Colony-Stimulating Factor
keywords: allograft; cancer; chemotherapy; perspective; retrospective; targeted therapies