title: Effect of Crocus sativus L. (saffron) on coagulation and anticoagulation systems in healthy volunteers.
abstract: Saffron showed some effects on blood coagulation and platelet aggregation in in vitro and in vivo studies. In a clinical trial with a limited number volunteers, saffron tablets influenced on bleeding time. In this study, the effect of saffron on plasma level of fibrinogen, factor VII (as coagulant agent), C and S protein (as anti-coagulant agent), PT and PTT in a larger sample size was evaluated. The study was a double-blind, placebo-controlled study consisting of 1 week treatment with 200 mg and 400 mg saffron tablets. Sixty healthy volunteers (age range 20-50 years) were selected for the study. The volunteers were divided into three groups of 20 each. Group 1 received placebo; Groups 2 and 3 received 200 mg and 400 mg saffron tablets, respectively, for 7 days (1 tablet per day). Before and after 7 days treatment and also 1 month after that, blood samples were taken. The plasma levels of fibrinogen, factor VII, C and S protein, PT and PTT were evaluated. Statistical analysis showed no difference between groups for any of evaluated factors. This study rejected any effect of saffron with dose of 200 and 400 mg for 1 week on coagulant and anticoagulant system.
authors.affiliation: Cancer Molecular Pathology Research Center, Department of Hematopathology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Ayatollahi
authors.forename: Atefeh Ordoei
authors.initials: AO
authors.lastname: Javan
authors.forename: Mohammad
authors.initials: M
authors.lastname: Khajedaluee
authors.forename: Masood
authors.initials: M
authors.lastname: Shahroodian
authors.forename: Hossein
authors.initials: H
authors.lastname: Hosseinzadeh
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D027622:Crocus / Q000737:chemistry*; D004311:Double-Blind Method; D005167:Factor VII / Q000737:chemistry; D005260:Female; D005340:Fibrinogen / Q000737:chemistry; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation / Q000187:drug effects*; D011486:Protein C / Q000737:chemistry; D017293:Protein S / Q000737:chemistry; D011517:Prothrombin Time; D013607:Tablets; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D011486:Protein C; D017293:Protein S; D013607:Tablets; D005167:Factor VII; D005340:Fibrinogen
keywords: Crocus sativus; anticoagulant; clinical trial; coagulation; platelet aggregation; saffron