title: β-Glucan signaling connects phagocytosis to autophagy.
abstract: A growing list of innate immune receptors is being defined that recognize polysaccharides of microbial cell walls. Fungal β-glucan recognition by the receptor Dectin-1 triggers inflammatory immune responses in macrophages and dendritic cells that are appropriate for defense against fungal pathogens. Among these responses is the specific recruitment of the autophagy-related protein light chain 3 (LC3) to phagosomes containing fungi. Studies documenting LC3's recruitment to phagosomes containing β-glucan and other nonsugar particles suggest that LC3 plays a role in regulating phagocytosis and its related immunological responses.
authors.affiliation: Research Division of Immunology, Department of Biomedical Sciences, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: David M
authors.initials: DM
authors.lastname: Underhill
mesh_terms: D000818:Animals; D001343:Autophagy / Q000276:immunology; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism; D010587:Phagocytosis / Q000276:immunology; D010588:Phagosomes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D015398:Signal Transduction / Q000276:immunology; D047071:beta-Glucans / Q000378:metabolism*; D000099181:Dectin-1
chemical_list: D037181:Lectins, C-Type; D047071:beta-Glucans; D000099181:Dectin-1
keywords: C-type lectin; autophagy; phagocytosis