title: T cell aging: a review of the transcriptional changes determined from genome-wide analysis.
abstract: Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells from aged hosts as well as subsets of T cells accumulated with age. Here, we aim to review the changes of gene expression in thymocytes and peripheral mature T cells, as well as the subsets of T cells accumulated with age, and discuss the gene networks and signaling pathways that are altered with aging in T cells. We also discuss future direction for furthering the understanding of the molecular basis of gene expression alterations in aged T cells, which could potentially provide opportunities for gene-based clinical interventions.
authors.affiliation: Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health Baltimore, MD, USA.
authors.forename: Guobing
authors.initials: G
authors.lastname: Chen
authors.forename: Ana
authors.initials: A
authors.lastname: Lustig
authors.forename: Nan-Ping
authors.initials: NP
authors.lastname: Weng
keywords: CD28− T cells; T cells; aging; naïve and memory T cells; thymocytes