title: The ortholog of the human proto-oncogene ROS1 is required for epithelial development in C. elegans.
abstract: The orphan receptor ROS1 is a human proto-oncogene, mutations of which are found in an increasing number of cancers. Little is known about the role of ROS1, however in vertebrates it has been implicated in promoting differentiation programs in specialized epithelial tissues. In this study we show that the C. elegans ortholog of ROS1, the receptor tyrosine kinase ROL-3, has an essential role in orchestrating the morphogenesis and development of specialized epidermal tissues, highlighting a potentially conserved function in coordinating crosstalk between developing epithelial cells. We also provide evidence of a direct relationship between ROL-3, the mucin SRAP-1, and BCC-1, the homolog of mRNA regulating protein Bicaudal-C. This study answers a longstanding question as to the developmental function of ROL-3, identifies three new genes that are expressed and function in the developing epithelium of C. elegans, and introduces the nematode as a potentially powerful model system for investigating the increasingly important, yet poorly understood, human oncogene ROS1.
authors.affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4. jonesmr@mail.ubc.ca
authors.forename: Martin R
authors.initials: MR
authors.lastname: Jones
authors.forename: Ann M
authors.initials: AM
authors.lastname: Rose
authors.forename: David L
authors.initials: DL
authors.lastname: Baillie
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism; D004848:Epithelium / Q000254:growth & development / Q000378:metabolism*; D009024:Morphogenesis / Q000235:genetics; D009077:Mucins / Q000378:metabolism; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; C000715470:MAS1 protein, human; D009077:Mucins; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; C584258:ROL-3 protein, C elegans; D020794:Receptor Protein-Tyrosine Kinases
keywords: Caenorhabditis elegans; ROL-3; ROS1 oncogene; cuticle; epithelial; seam cells