title: Structures and biosynthesis of 12-membered macrocyclic depsipeptides from Streptomyces sp. ML55.
abstract: Two novel depsipeptides (1-2) were isolated from Streptomyces sp. ML55 together with two known analogues (3-4). Their structures were elucidated using a combination of NMR experiments, as well as detailed MS/MS experiments. The biosynthetic pathway of isolated compounds was dissected by genome sequencing data analysis for a hybrid nonribosomal peptide synthetase (NRPS) and polyketide synthetase (PKS) assembly line.
authors.affiliation: Department of Biochemistry and Biomedical Sciences, M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Rostyslav
authors.initials: R
authors.lastname: Zvanych
authors.forename: Jonathon
authors.initials: J
authors.lastname: Torchia
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Magarvey
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D047630:Depsipeptides / Q000096:biosynthesis* / Q000737:chemistry / Q000633:toxicity; D019073:HT29 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D005810:Multigene Family; D010453:Peptide Synthases / Q000378:metabolism; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*; D053719:Tandem Mass Spectrometry
chemical_list: D047630:Depsipeptides; D010453:Peptide Synthases