title: Hepatic Steatosis, Carbohydrate Intake, and Food Quotient in Patients with NAFLD.
abstract: Is steatosis related to the spontaneous carbohydrate intake in patients with NAFLD? We performed dietary records for 24 patients with NAFLD, 3 months after their liver biopsy was performed and before the deliverance of a dietary advice. The food quotient, indicator of the proportion of calories from carbohydrates, was calculated as (1.00×%  calories from carbohydrates/100) + (0.70×%  calories from lipids/100) + (0.81×%  calories from proteins/100). The associations between diet variables and steatosis% on the hepatic biopsies were tested by regression analysis, and diet variables were compared according to the presence of fibrosis. The subjects displayed a large range of steatosis, 50.5% ± 25.5 [10-90], correlated with their energy intake (1993 ± 597 kcal/d, r = 0.41, P < 0.05) and food quotient (0.85 ± 0.02, r = 0.42, P < 0.05), which remained significant with both variables by a multivariate regression analysis (r = 0.51, P < 0.05). For the 17/24 patients with a hepatic fibrosis, the energy intake was lower (fibrosis: 1863 ± 503 versus others: 2382 ± 733 kcal/d, P < 0.05), and their food quotients did not differ from patients without fibrosis. Hepatic steatosis was related to the energy and carbohydrate intakes in our patients; the role of dietary carbohydrates was detectable in the range of usual carbohydrate intake: 32% to 58% calories.
authors.affiliation: Pôle Hépatogastroentérologie, Endocrinologie et Nutrition, CHU de Bordeaux, Avenue de Magellan, 33600 Pessac, France.
authors.forename: Concepcion
authors.initials: C
authors.lastname: Gonzalez
authors.forename: Victor
authors.initials: V
authors.lastname: de Ledinghen
authors.forename: Julien
authors.initials: J
authors.lastname: Vergniol
authors.forename: Juliette
authors.initials: J
authors.lastname: Foucher
authors.forename: Brigitte
authors.initials: B
authors.lastname: Le Bail
authors.forename: Sabrina
authors.initials: S
authors.lastname: Carlier
authors.forename: Elisa
authors.initials: E
authors.lastname: Maury
authors.forename: Henri
authors.initials: H
authors.lastname: Gin
authors.forename: Vincent
authors.initials: V
authors.lastname: Rigalleau