title: Evaluation of antifungal activity of free fatty acids methyl esters fraction isolated from Algerian Linum usitatissimum L. seeds against toxigenic Aspergillus.
abstract: OBJECTIVE
  The aim of this study was to evaluate the antifungal activity of the major fraction of fatty acids methyl esters (FAMEs) isolated from Linum usitatissimum L. seeds oil collected from Bechar department (Algeria).
  
  
  METHODS
  The assessment of antifungal activity was carried out in terms of percentage of radial growth on solid medium (potatoes dextrose agar PDA) and biomass growth inhibition on liquid medium (potatoes dextrose broth PDB) against two fungi.
  
  
  RESULTS
  The FAMEs was found to be effective in inhibiting the radial mycelial growth of Aspergillus flavus more than Aspergillus ochraceus on all tested concentrations. The highest antifungal index was found to be (54.19%) compared to Aspergillus ochraceus (40.48%). The results of the antifungal activity of the FAMEs inhibition of biomass on liquid medium gave no discounted results, but this does not exclude the antifungal activity.
  
  
  CONCLUSIONS
  We can assume that the observed antifungal potency may be due to the abundance of linoleic and α-linolenic acids in linseed oil which appears to be promising to treat fungal infections, storage fungi and food spoilage in food industry field.
authors.affiliation: Laboratory of Natural Products Research (LAPRONA) University of Tlemcen, Algeria ; Laboratory of Plant Resource Development and Food Security in Semi Arid Areas, South West of Algeria, University of Bechar, Algeria.
authors.forename: Amrouche
authors.initials: A
authors.lastname: Abdelillah
authors.forename: Benmehdi
authors.initials: B
authors.lastname: Houcine
authors.forename: Dalile
authors.initials: D
authors.lastname: Halima
authors.forename: Chabane sari
authors.initials: Cs
authors.lastname: Meriem
authors.forename: Zaaboub
authors.initials: Z
authors.lastname: Imane
authors.forename: Smahi Djamal
authors.initials: SD
authors.lastname: Eddine
authors.forename: Moussaoui
authors.initials: M
authors.lastname: Abdallah
authors.forename: Chabane sari
authors.initials: Cs
authors.lastname: Daoudi
mesh_terms: D000462:Algeria; D000935:Antifungal Agents / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000187:drug effects*; D001235:Aspergillus ochraceus / Q000187:drug effects*; D004952:Esters / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology; D019597:Flax / Q000737:chemistry*; D005659:Fungicides, Industrial / Q000494:pharmacology*; D008043:Linseed Oil / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D012639:Seeds / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D004952:Esters; D005230:Fatty Acids, Nonesterified; D005659:Fungicides, Industrial; D008043:Linseed Oil
keywords: Antifungal activity; Aspergillus; Extraction; FAMEs; Linum usitatissimum L.