title: Chemoselective benzylation of unprotected anthranilic acids with benzhydryl alcohols by water-soluble Au(III)/TPPMS in water.
abstract: A novel and efficient method for the benzylation of unprotected anthranilic acids with benzhydryl alcohols using water-soluble Au(III)/TPPMS in water is developed. Water plays an important role in our catalytic system. This new protocol could be used for not only N-benzylation, but also chemoselective C-benzylation by the Friedel-Crafts reaction.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan. hidemasa.hikawa@phar.toho-u.ac.jp
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Hikawa
authors.forename: Hideharu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Yuusaku
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Isao
authors.initials: I
authors.lastname: Azumaya
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D001557:Benzenesulfonates / Q000737:chemistry*; D001559:Benzhydryl Compounds / Q000737:chemistry*; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry; D062367:ortho-Aminobenzoates / Q000737:chemistry*
chemical_list: D000438:Alcohols; D001557:Benzenesulfonates; D001559:Benzhydryl Compounds; D010720:Phosphines; D062367:ortho-Aminobenzoates; D014867:Water; D006046:Gold