title: Measurement of vitamin A, vitamin E, selenium, and L-lactate in dogs with and without osteoarthritis secondary to ruptured cranial cruciate ligament.
abstract: This study compared vitamin A, vitamin E, selenium (Se), and L-lactate in blood and synovial fluid in 2 groups of 6 dogs; a control group (without OA) and an osteoarthritic group with spontaneous cranial cruciate ligament rupture and OA. Concentrations of vitamin E were significantly higher in serum than in synovial fluid in both OA (P = 0.006) and control (P = 0.0008) groups. Vitamin E concentration in synovial fluid was significantly higher in the OA group than in the control group (P = 0.009). Concentrations of Se were significantly higher in serum than in synovial fluid in both OA (P = 0.003) and control (P = 0.0006) groups. There were no significant differences in levels of Se, vitamin A, and L-lactate between the 2 groups. This is the first study to show an increased concentration of vitamin E in the synovial fluid of dogs with OA compared with dogs that did not have OA.
authors.affiliation: Département des Sciences Cliniques, Faculté de médecine vétérinaire, 3200, Sicotte CP 5000, Saint-Hyacinthe, Quebec J2S 7C6. a.de.oliveira.el.warrak@umontreal.ca
authors.forename: Alexander
authors.initials: A
authors.lastname: de Oliveira El-Warrak
authors.forename: Mouhamed
authors.initials: M
authors.lastname: Rouma
authors.forename: Audrey
authors.initials: A
authors.lastname: Amoroso
authors.forename: Soren R
authors.initials: SR
authors.lastname: Boysen
authors.forename: Younés
authors.initials: Y
authors.lastname: Chorfi
mesh_terms: D000818:Animals; D000070598:Anterior Cruciate Ligament Injuries; D016022:Case-Control Studies; D004283:Dog Diseases / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D005260:Female; D007773:Lactates / Q000097:blood; D008297:Male; D010003:Osteoarthritis / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D012422:Rupture, Spontaneous / Q000097:blood / Q000378:metabolism / Q000662:veterinary; D012643:Selenium / Q000097:blood / Q000378:metabolism; D013582:Synovial Fluid / Q000737:chemistry*; D014801:Vitamin A / Q000097:blood / Q000378:metabolism; D014810:Vitamin E / Q000097:blood / Q000378:metabolism
chemical_list: D007773:Lactates; D014801:Vitamin A; D014810:Vitamin E; D012643:Selenium