title: Lung function after preterm birth: development from mid-childhood to adulthood.
abstract: BACKGROUND
  As a result of advances in perinatal care, more small preterm infants survive. There are concerns that preterm birth and its treatments may harm pulmonary development and thereby lead to chronic airway obstruction in adulthood.
  
  
  OBJECTIVE
  To assess the development of spirometric lung function variables from mid-childhood to adulthood after extreme preterm birth.
  
  
  METHODS
  Two population-based cohorts born at gestational age ≤28 weeks or with birth weight ≤1000 g performed lung function tests at 10 and 18 and at 18 and 25 years of age, respectively, together with matched term-born controls. The results are presented as z scores, normalised for age, sex and height. Longitudinal development was compared for groups born at term and preterm, split by a history of absence (n=20), mild (n=38) or moderate/severe (n=25) neonatal bronchopulmonary dysplasia (BPD).
  
  
  RESULTS
  The preterm-born cohorts, particularly those with neonatal BPD, had significantly lower forced expiratory volume in 1 s and mid-expiratory flow than those born at term at all assessments (z scores in the range -0.40 to -1.84). Within each of the subgroups the mean z scores obtained over the study period were largely similar, coefficients of determination ranging from 0.64 to 0.82. The pattern of development for the BPD subgroups did not differ from each other or from the groups born at term (tests of interaction).
  
  
  CONCLUSIONS
  Airway obstruction was present from mid-childhood to adulthood after extreme preterm birth, most evident after neonatal BPD. Lung function indices were tracking similarly in the preterm and term-born groups.
authors.affiliation: Department of Clinical Science, Section for Pediatrics, University of Bergen, Bergen, Norway. maria.vollsaeter@helse-bergen.no
authors.forename: Maria
authors.initials: M
authors.lastname: Vollsæter
authors.forename: Ola Drange
authors.initials: OD
authors.lastname: Røksund
authors.forename: Geir Egil
authors.initials: GE
authors.lastname: Eide
authors.forename: Trond
authors.initials: T
authors.lastname: Markestad
authors.forename: Thomas
authors.initials: T
authors.lastname: Halvorsen
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D001997:Bronchopulmonary Dysplasia / Q000209:etiology / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D047928:Premature Birth / Q000503:physiopathology*; D012143:Respiratory Physiological Phenomena; D013147:Spirometry; D055815:Young Adult
keywords: COPD epidemiology; Clinical Epidemiology; Paediatric Lung Disaese