title: [Tadalafil combined with behavior therapy for semen collection from infertile males in whom masturbation fails].
abstract: OBJECTIVE
  To study the effect of Tadalafil combined with behavior therapy in helping obtain semen from infertile men in whom masturbation has failed.
  
  
  METHODS
  Sixty male infertile patients from whom masturbation had failed to obtain semen were equally assigned to receive Tadalafil combined with behavior therapy (combination group) or Tadalafil only (control group). All the patients took Tadalafil 20 mg orally the night before the day of semen collection by masturbation. Before this procedure, the patients of the combination group practiced masturbation 16 - 24 times at home.
  
  
  RESULTS
  The average ages of the patients were (37.0 +/- 5.1) yr and (37.5 +/- 5.2) yr and their IIEF-5 scores were 16.50 +/- 1.25 and 16.90 +/- 1.09 in the combination and the control group, respectively, neither with statistically significant difference between the two groups. Semen was successfully obtained from 9 patients (30.0%) of the combination group and 1 patient (3.33%) of the control group, with statistically significant difference between the two groups (chi2 = 7.680, P < 0.01).
  
  
  CONCLUSIONS
  By training the patients and establishing a conditioned response to masturbation, Tadalafil combined with behavior therapy can significantly increase the success rate of semen collection from the male infertile patients in whom masturbation fails.
authors.affiliation: Department of Urology, Peking University Third Hospital, Beijing 100191, China. tangwenhao9696@sohu.com
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Tang
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.forename: Lu-Lin
authors.initials: LL
authors.lastname: Ma
authors.forename: Kai
authors.initials: K
authors.lastname: Hong
authors.forename: Lian-Ming
authors.initials: LM
authors.lastname: Zhao
authors.forename: De-Feng
authors.initials: DF
authors.lastname: Liu
authors.forename: Jia-Ming
authors.initials: JM
authors.lastname: Mao
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Ju
authors.initials: J
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Gao
authors.forename: Jie
authors.initials: J
authors.lastname: Qiao
mesh_terms: D000328:Adult; D001521:Behavior Therapy; D002243:Carbolines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008418:Masturbation / Q000628:therapy*; D008875:Middle Aged; D012661:Semen; D000068581:Tadalafil; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D002243:Carbolines; D000068581:Tadalafil