title: Seroprevalence of Bordetella pertussis in the Mexican population: a cross-sectional study.
abstract: SUMMARY Serum samples collected during the National Health and Nutrition survey (ENSANUT 2006) were obtained from subjects aged 1-95 years (January-October 2010) and analysed to assess the seroprevalence of Bordetella pertussis (BP) in Mexico. Subjects' gender, age, geographical region and socioeconomic status were extracted from the survey and compiled into a subset database. A total of 3344 subjects (median age 29 years, range 1-95 years) were included in the analysis. Overall, BP seroprevalence was 47.4%. BP seroprevalence was significantly higher in males (53.4%, P = 0.0007) and highest in children (59.3%) decreasing with advancing age (P = 0.0008). BP seroprevalence was not significantly different between regions (P = 0.1918) and between subjects of socioeconomic status (P = 0.0808). Women, adolescents and young adults were identified as potential sources of infection to infants. Booster vaccination for adolescents and primary contacts (including mothers) for newborns and infants may provide an important public health intervention to reduce the disease burden.
authors.affiliation: Instituto Nacional de Salud Pública (INSP), Avenida Universidad, Colonia Santa María Ahuacatitlán, Cuernavaca, Morelos, México.
authors.forename: C
authors.initials: C
authors.lastname: Conde-Glez
authors.affiliation: Instituto Nacional de Salud Pública (INSP), Avenida Universidad, Colonia Santa María Ahuacatitlán, Cuernavaca, Morelos, México.
authors.forename: E
authors.initials: E
authors.lastname: Lazcano-Ponce
authors.affiliation: Instituto Nacional de Salud Pública (INSP), Avenida Universidad, Colonia Santa María Ahuacatitlán, Cuernavaca, Morelos, México.
authors.forename: R
authors.initials: R
authors.lastname: Rojas
authors.affiliation: GlaxoSmithKline Vaccines, Avenue Fleming 20 (W23), Wavre, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: DeAntonio
authors.affiliation: GlaxoSmithKline Vaccines, Calzada México Xochimilco, Colonia San Lorenzo Huipulco, Delegacíon Tlalpan, México D.F., México.
authors.forename: L
authors.initials: L
authors.lastname: Romano-Mazzotti
authors.affiliation: GlaxoSmithKline Vaccines, Calzada México Xochimilco, Colonia San Lorenzo Huipulco, Delegacíon Tlalpan, México D.F., México.
authors.forename: Y
authors.initials: Y
authors.lastname: Cervantes
authors.affiliation: GlaxoSmithKline Vaccines, Clayton, Ciudad del Saber, Panamá, Panamá
authors.forename: E
authors.initials: E
authors.lastname: Ortega-Barría
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood; D001886:Bordetella pertussis / Q000276:immunology; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D010567:Pertussis Vaccine; D016036:Seroepidemiologic Studies; D014917:Whooping Cough / Q000453:epidemiology* / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D010567:Pertussis Vaccine