title: Regioselective synthesis of multisubstituted benzenes by palladium-catalyzed intermolecular reaction of β-iodo-β-silylstyrenes with alkynes.
abstract: The Pd-catalyzed reaction between β-iodo-β-silylstyrenes and terminal alkynes in i-Pr2NEt gave 1,2,3,5-tetrasubstituted benzenes with complete regioselection. The use of certain silylacetylenes as alkynes enabled efficient synthesis of 1,3,5-trissilyl-2-arylbenzenes, which could be transformed into other multisubstituted benzenes by displacement of the silyl groups.
authors.affiliation: Department of Applied Chemistry, Graduate School of Science and Engineering, Saitama University , 255 Shimo-ohkubo, Sakura-ku, Saitama 338-8570, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Katsukiyo
authors.initials: K
authors.lastname: Miura
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013343:Styrenes / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001555:Benzene Derivatives; D017646:Organosilicon Compounds; D013343:Styrenes; D010165:Palladium