title: Attenuation of stress-induced behavioral deficits by lithium administration via serotonin metabolism.
abstract: BACKGROUND
  Although the mood stabilizing role of lithium is well established and the cognitive effects of lithium are also best demonstrated, but its primary effect on neurochemical profile and behaviors under stress remain ambiguous. Earlier studies have suggested that a single exposure to 2 h immobilization stress alters memory in various memory tasks, decreases exploratory activity in open field test and increases serotonin metabolism. This study is designed to investigate the stress relieving effect of lithium in rats.
  
  
  METHODS
  Rats were orally administered with lithium carbonate (1 mg/kg/ml) while controls received an equal volume of water for 21 days. After 21 days, each group of rats was sub-divided into stressed and unstressed groups. Animals of stressed group received immobilization stress for 2 h and 24 h following stress behavioral analysis was performed, after which animals were decapitated and their brain samples were collected for neurochemical estimation by HPLC-EC.
  
  
  RESULTS
  Results of the present study show that 2 h immobilization stress decreases locomotor activity while impairs memory performance. Prior administration of lithium attenuates memory impairment and locomotion suppressant effects of stress by reversing the stress induced brain serotonin metabolism in lithium treated rats.
  
  
  CONCLUSIONS
  Thus, the results of this study suggest that lithium may recover behavioral and neurochemical impairments induced by stress.
authors.affiliation: Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Unit, University of Karachi, Karachi 75270, Pakistan. tahiraatiq@hotmail.com
authors.forename: Tahira
authors.initials: T
authors.lastname: Perveen
authors.forename: Saida
authors.initials: S
authors.lastname: Haider
authors.forename: Wajeeha
authors.initials: W
authors.lastname: Mumtaz
authors.forename: Faiza
authors.initials: F
authors.lastname: Razi
authors.forename: Saiqa
authors.initials: S
authors.lastname: Tabassum
authors.forename: Darakhshan J
authors.initials: DJ
authors.lastname: Haleem
mesh_terms: D000284:Administration, Oral; D000818:Animals; D018692:Antimanic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D007103:Immobilization; D016651:Lithium Carbonate / Q000494:pharmacology*; D008569:Memory Disorders / Q000188:drug therapy / Q000209:etiology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D013315:Stress, Psychological / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D018692:Antimanic Agents; D016651:Lithium Carbonate; D012701:Serotonin