title: Association between eprosartan-based hypertension therapy and improvement in cognitive function score: long-term follow-up from the OSCAR observational study.
abstract: OBJECTIVE
  The Observational Study on Cognitive function And systolic blood pressure Reduction (OSCAR) was designed to evaluate the impact of eprosartan-based therapy on cognitive function in a cohort of 25,745 hypertensive subjects followed for six months.
  
  
  METHODS
  In this supplementary analysis, we studied the relationship between eprosartan-based therapy and cognitive function (assessed using the Mini-Mental State Examination (MMSE)) after 12-month follow-up of 3600 patients (the long-term follow-up on-treatment population).
  
  
  RESULTS
  Reduction in blood pressure was sustained over 12 months, with mean systolic blood pressure/diastolic blood pressure 130.9/79 mmHg at one year, compared with 164.3/92.8 mmHg at baseline (p<0.001). The overall mean MMSE score at completion of 12-month follow-up was significantly increased from baseline (27.8 ± 2.7 vs. 26.3 ± 3.5; p<0.001). The increase in MMSE score was observed when the population was stratified by age (p<0.001) and in a subgroup of patients with cerebrovascular disease at baseline (n=290) (p<0.001, 12 months vs. baseline).
  
  
  CONCLUSIONS
  In this cohort of patients, use of eprosartan-based treatment for one year was associated with sustained reduction in blood pressure and stabilization or improvement of MMSE scores. These data are supportive of a role for blood pressure control in the prevention or delay of cognitive decline.
authors.affiliation: AP-HP, Geriatric Department, Hôpital Broca, Paris, France University Paris Descartes, Sorbonne Paris Cité, Paris, France olivier.hanon@brc.aphp.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Hanon
authors.affiliation: Seoul Metropolitan Government-Seoul National University Boramae Medical Centre, Seoul, South Korea.
authors.forename: Yong-Seok
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Clinical Pharmacology Service, Toulouse University Hospital and Faculty of Medicine, France.
authors.forename: Atul
authors.initials: A
authors.lastname: Pathak
mesh_terms: D000179:Acrylates / Q000494:pharmacology / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D003710:Demography; D003971:Diastole / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D013599:Systole / Q000187:drug effects; D013876:Thiophenes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000179:Acrylates; D007093:Imidazoles; D013876:Thiophenes; C068373:eprosartan
keywords: Hypertension; MMSE; cognition; eprosartan; long-term