title: [Transport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasis].
abstract: OBJECTIVE
  To characterise and compare the in vitro transport properties of respiratory mucoid secretion in individuals with no lung disease and in stable patients with chronic obstructive pulmonary disease (COPD) and bronchiectasis.
  
  
  METHODS
  Samples of mucus were collected, from 21 volunteers presenting no lung disease who had undergone surgery, from 10 patients presenting chronic COPD, and from 16 patients with bronchiectasis. Mucociliary transport (MCT), transport by cough (SCM), and contact angle (CAM) were evaluated.
  
  
  RESULTS
  MCT was found to be greater in healthy individuals (1.0±0.19) than in COPD (0.91±0.17) and bronchiectasis (0.76±0.23) patients (p<0.05), whereas SCM was greater in COPD patients (16.31±7.35 cm) than in patients with bronchiectasis (12.16±6.64 cm) and healthy individuals (10.50±25.8 cm) (p<0.05). No significant differences were observed between the groups regarding CAM.
  
  
  CONCLUSIONS
  Mucus from healthy individuals allows better mucociliary transport compared to that from patients with lung diseases. However, the mucus from COPD patients allows a better transport by coughing, demonstrating that these individuals have adapted to a defence mechanism compared to patients with bronchiectasis, who have impairment in their ciliary and cough transport mechanisms.
authors.affiliation: Pós Graduação, Departamento de Fisioterapia, Centro Universitário do Triângulo, Uberlândia, Brasil.
authors.forename: J
authors.initials: J
authors.lastname: Lima Afonso
authors.forename: J
authors.initials: J
authors.lastname: Tambascio
authors.forename: H C
authors.initials: HC
authors.lastname: Dutra de Souza
authors.forename: J R
authors.initials: JR
authors.lastname: Jardim
authors.forename: J A
authors.initials: JA
authors.lastname: Baddini Martinez
authors.forename: A C
authors.initials: AC
authors.lastname: Gastaldi
mesh_terms: D001987:Bronchiectasis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000502:physiology*; D009093:Mucus / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D055815:Young Adult
keywords: Bronchiectasis; Bronquiectasia; COPD; DPOC; Depuração mucociliar; Muco respiratório; Mucociliary clearance; Respiratory mucus