title: Acyloxymethyl esters of isophosphoramide mustard as new anticancer prodrugs.
abstract: A series of new prodrugs: [bis(2-chloroethylamino)phosphoryloxy]methyl acetate, [bis(2-chloroethylamino)phosphoryloxy]methyl pivalate and [bis(2-chloroethylamino)phosphoryloxy]methyl benzoate, was obtained in the reaction of isophosphoramide mustard (iPAM) with the corresponding acyloxymethyl halides. The cytotoxic activity of these new compounds is also shown. All compounds were highly active in the inhibition of cancer cell proliferation against the human lung (A594), prostate (PC-3) and breast (MCF-7) cancer cell lines.
authors.affiliation: Department of Chemical Technology of Pharmaceuticals, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85-094 Bydgoszcz, Poland. cytar@cm.umk.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Cytarska
authors.forename: Konrad
authors.initials: K
authors.lastname: Misiura
authors.forename: Beata
authors.initials: B
authors.lastname: Filip-Psurska
authors.forename: Joanna
authors.initials: J
authors.lastname: Wietrzyk
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001711:Biotransformation; D045744:Cell Line, Tumor; D004355:Drug Stability; D006801:Humans; D010752:Phosphoramide Mustards / Q000138:chemical synthesis* / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D010752:Phosphoramide Mustards; D011355:Prodrugs; C027061:isophosphamide mustard