title: Biweekly docetaxel, fluorouracil, leucovorin, oxaliplatin (TEF) as first-line treatment for advanced gastric cancer and adenocarcinoma of the gastroesophageal junction: safety and efficacy in a multicenter cohort.
abstract: BACKGROUND
  Docetaxel-cisplatin-5-FU chemotherapy is superior to 5-FU-cisplatin in terms of response rate and survival in advanced gastric cancer (AGC), but is more toxic. Oxaliplatin is better tolerated than cisplatin, which it can effectively replace in this setting. We hypothesize that incorporating docetaxel into a simplified FOLFOX regimen should be a tolerable and effective option in first-line treatment of AGC.
  
  
  METHODS
  Data were collected at six French centers from patients with metastatic or local AGC who received docetaxel, fluorouracil, leucovorin, or oxaliplatin (TEF) as first-line treatment. TEF was administered as follows: docetaxel (50 mg/m(2)), oxaliplatin (85 mg/m(2)), and leucovorin (40 mg/m(2)) on day 1, and 5-FU continuous infusion for 48 h (2400 mg/m(2)) every 2 weeks.
  
  
  RESULTS
  Forty-one patients were enrolled. Performance status was grade 0 and 1 in respectively 27 and 58 % of patients; 17 patients had adenocarcinoma of the gastroesophageal junction; 37 patients had metastatic disease, 22 had a poorly differentiated or diffuse type. Objective response rate was 66 %, with a complete response in two patients (5 %). Median progression-free survival and overall survival were respectively 6.3 and 12.1 months. Tolerability was acceptable with no treatment-related deaths. The most frequent grade 3-4 toxicities were neutropenia (30 %) and neuropathy (12.5 %). Curative intent surgery after response to TEF was performed in seven patients (17 %).
  
  
  CONCLUSIONS
  TEF is an effective first-line treatment with an acceptable toxicity profile for patients with AGC. It may allow curative resection in initially unresectable patients. TEF should now be evaluated in prospective randomized trials.
authors.affiliation: HEGP, APHP, Paris Sorbonne Cité, Université Paris Descartes, Paris, France, simon.pernot@gmail.com.
authors.forename: Simon
authors.initials: S
authors.lastname: Pernot
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mitry
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Samalin
authors.forename: Laetitia
authors.initials: L
authors.lastname: Dahan
authors.forename: Cécile
authors.initials: C
authors.lastname: Dalban
authors.forename: Marc
authors.initials: M
authors.lastname: Ychou
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Seitz
authors.forename: Hajer
authors.initials: H
authors.lastname: Turki
authors.forename: Thibault
authors.initials: T
authors.lastname: Mazard
authors.forename: Aziz
authors.initials: A
authors.lastname: Zaanan
authors.forename: Céline
authors.initials: C
authors.lastname: Lepère
authors.forename: Jean-Nicolas
authors.initials: JN
authors.lastname: Vaillant
authors.forename: Bruno
authors.initials: B
authors.lastname: Landi
authors.forename: Philippe
authors.initials: P
authors.lastname: Rougier
authors.forename: Julien
authors.initials: J
authors.lastname: Taieb
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000077143:Docetaxel; D004943:Esophagogastric Junction / Q000473:pathology*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D011379:Prognosis; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D009944:Organoplatinum Compounds; D043823:Taxoids; D000077150:Oxaliplatin; D000077143:Docetaxel; D002955:Leucovorin; D005472:Fluorouracil