title: Autologous stem cell transplantation as first line treatment after incomplete excision of pancreatoblastoma.
abstract: Pancreatoblastoma is a rare tumor and surgery with complete resection is the main treatment approach. Prognosis for patients with residual disease after surgery is usually dismal. A 14-year-old girl with pancreatoblastoma in the pancreatic body and tail was submitted to preoperative chemotherapy. She underwent surgery and the tumor was resected with microscopic margins. Postoperative chemotherapy was followed by high dose chemotherapy and autologous hematopoietic stem cell transplantation. After four years she remains very well with no evidence of disease. This is the first case reported of pancreatoblastoma that was treated with autologous hematopoietic stem cell transplantation as first line treatment without radiotherapy at the site of the microscopic disease.
authors.affiliation: Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil.
authors.forename: Clarice Franco
authors.initials: CF
authors.lastname: Meneses
authors.forename: Carolina Dame
authors.initials: CD
authors.lastname: Osório
authors.forename: Claudio Galvão
authors.initials: CG
authors.lastname: de Castro Junior
authors.forename: Algemir Lunardi
authors.initials: AL
authors.lastname: Brunetto
keywords: Drug therapy, combination; Hematopoietic stem cell transplantation; Pancreatic neoplasms; Pediatrics; Primary treatment