title: Short-term aerobic exercise training increases postprandial pancreatic polypeptide but not peptide YY concentrations in obese individuals.
abstract: OBJECTIVE
  Short-term exercise training improves glycemic control, but the effect of short-term training on postprandial satiety peptide responses or perceived satiety remains unknown. We tested the hypothesis that short-term aerobic exercise training (15 days) would alter postprandial pancreatic and gut peptide (pancreatic polypeptide (PP) and peptide YY (PYY)) responses and perceived appetite and satiety in obese individuals.
  
  
  METHODS
  Thirteen healthy obese men and women (age: 42±2 years; body mass index: 30-45 kg m(-2)).
  
  
  METHODS
  Subjects were studied before and after 15 days of training (walking 1 h at 70-75% VO(2peak)). On the study day, subjects consumed 1500 kcal as six meals (250 kcal: 9 g protein, 40 g carbohydrate, 6 g fat), while blood samples and satiety measurements were taken at baseline and every 20 min for 12 h. Blood was analyzed for PP, PYY, glucose and insulin levels. Appetite and satiety was assessed with a visual analog scale throughout the day.
  
  
  RESULTS
  Incremental area under the curve (iAUC) for PP increased significantly with training (pre: 2788±753; post: 3845±830 pg ml(-1)·per min for 12 h; P<0.001), but there was no difference in the PP response to each meal. The initial PP response to the first meal increased (ΔPP(min 20-0): pre 86±25; post 140±36 pg ml(-1); P<0.05) with training. PYY iAUC showed no significant changes with training but showed a significant main effect of time across meals, with the largest response being to the first meal (P<0.005). There were no changes in satiety, glucose or insulin levels with training.
  
  
  CONCLUSIONS
  Short-term exercise training increases postprandial PP concentrations in obese individuals; however, PYY levels and glycemic control remain unaffected. Both PP and PYY show meal-induced increases at all meals, but PYY has a greater response at the first meal with reduced responses at subsequent meals.
authors.affiliation: Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Kanaley
authors.affiliation: Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA.
authors.forename: T D
authors.initials: TD
authors.lastname: Heden
authors.affiliation: Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Internal Medicine, Division of Nephrology Internal Medicine, Columbia, MO, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Whaley-Connell
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Medicine, Columbia, MO, USA.
authors.forename: A
authors.initials: A
authors.lastname: Chockalingam
authors.affiliation: 1] Department of Internal Medicine, Division of Nephrology Internal Medicine, Columbia, MO, USA [2] Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA.
authors.forename: K C
authors.initials: KC
authors.lastname: Dellsperger
authors.affiliation: School of Chiropractic and Sports Science, Murdoch University, Murdoch, Western Australia, Australia.
authors.forename: T J
authors.initials: TJ
authors.lastname: Fairchild
mesh_terms: D000328:Adult; D001066:Appetite; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002149:Energy Intake; D015444:Exercise; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood* / Q000378:metabolism / Q000503:physiopathology; D010191:Pancreatic Polypeptide / Q000097:blood*; D019894:Peptide YY / Q000097:blood*; D019518:Postprandial Period; D012527:Satiation; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D019894:Peptide YY; D010191:Pancreatic Polypeptide