title: The risk of elective orthopaedic surgery for haemophilia patients: Japanese single-centre experience.
abstract: Haemophilic arthropathy causes pain and a severely restricted range of motion, and results in a significant reduction in quality of life. When conservative treatments have failed, orthopaedic surgery is recommended for these patients with severe haemophilic arthropathy. However, surgery for haemophilia patients is challenging due to high complication rate such as infection, delayed wound healing and mortality. The aim of this study was to evaluate the incidence of early complications and identify preoperative risk factors of surgery for haemophilia patients. We report a series of haemophilia patients undergoing elective orthopaedic surgery between 2006 and 2012. During this period, 119 surgeries in 81 patients were prepared and 118 surgeries in 80 patients were actually performed. Four deep bacterial infections and four delayed wound healings occurred within 6 months postoperatively. One patient died preoperatively and four patients died postoperatively. Only the presence of inhibitor was a significant risk factor for infection. We found no risk factor related to delayed wound healing. Our data revealed alkaline phosphatase, albumin, platelet, alpha-fetoprotein, presence of ascites and child classification C as predictors of perioperative mortality following elective orthopaedic surgery. Our role is to identify potential patients who present with risk factors for complications and attempt to seek the best determination of treatment strategy for these people.
authors.affiliation: Faculty of Medicine, Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan; Department of Joint Surgery, IMSUT Hospital of the Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Hirose
authors.forename: H
authors.initials: H
authors.lastname: Takedani
authors.forename: T
authors.initials: T
authors.lastname: Koibuchi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000209:etiology; D025861:Blood Coagulation Disorders, Inherited / Q000150:complications* / Q000401:mortality; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D007564:Japan; D007592:Joint Diseases / Q000150:complications / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures; D011183:Postoperative Complications; D012307:Risk Factors; D013163:Splenomegaly / Q000209:etiology; D014945:Wound Healing; D055815:Young Adult
keywords: Japanese; complication; elective orthopaedic surgery; haemophilia; risk factor; single centre