title: ALDH2, a novel protector against stroke?
abstract: In a recent paper published in Cell Research, an association between expression of mitochondrial aldehyde dehydrogenase (ALDH2), a mitochondrial chaperon expressed in the brain, and the prevalence of stroke is revealed. This finding indicates that ALDH2 may serve as a potential endogenous neuroprotective target and a promising therapeutic strategy for the management of stroke.
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000378:metabolism*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000447:Aldehydes / Q000097:blood* / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008297:Male; D024101:Mitochondrial Proteins / Q000378:metabolism*; D020521:Stroke / Q000378:metabolism*
chemical_list: D000447:Aldehydes; D024101:Mitochondrial Proteins; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; C505112:Aldh2 protein, rat; C027576:4-hydroxy-2-nonenal