title: Thermo- and pH-sensitive dendrosomes as bi-phase drug delivery systems.
abstract: Fully supramolecular dendrosomes (FSD) as bi-phase drug delivery systems are reported in this work. For preparation of FSD, amphiphilic linear-dendritic supramolecular systems (ALDSS) have been synthesized by host-guest interactions between hyperbranched polyglycerol having β-cyclodextrin core and bi-chain polycaprolactone (BPCL) with a fluorescine focal point. Self-assembly of ALDSS in aqueous solutions led to FSD. They were able to encapsulate paclitaxel with a high loading capacity. The dendrosome-based drug delivery systems were highly sensitive to pH and temperature. They were stable at 20-37 °C and pH7-8, but dissociated and released drug at temperatures lower than 20 °C or higher than 37 °C and pH lower than 7 quickly. Dissociation of FSD building blocks by temperature or pH resulted in inclusion complexes between the released drugs and polyglycerol as the secondary drug delivery system.
  
  
  BACKGROUND
  This paper reports on the development of a pH- (below 7) and temperature- (below 20 °C or above 37 °C) sensitive delivery system using supramolecular dendrosomes for more specific delivery and release of drugs using paclitaxel as a model.
authors.affiliation: Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad, Iran; Department of Chemistry, Sharif University of Technology, Tehran, Iran. Electronic address: adeli@sharif.edu.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Adeli
authors.forename: Ali Kakanejadi
authors.initials: AK
authors.lastname: Fard
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Abedi
authors.forename: Beheshteh Khodadadi
authors.initials: BK
authors.lastname: Chegeni
authors.forename: Farhad
authors.initials: F
authors.lastname: Bani
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems; D005990:Glycerol / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D017239:Paclitaxel / Q000008:administration & dosage*; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D011091:Polyesters; D011108:Polymers; D047392:beta-Cyclodextrins; C016240:polycaprolactone; C043941:polyglycerol; C031215:betadex; D017239:Paclitaxel; D005990:Glycerol
keywords: AFM; ALDSS; Amphiphilic linear-dendritic supramolecular systems; Atomic force microscopy; BPCL; Biphase-drug delivery systems; CAC; Controlled release; DLC; DLE; DLS; Dendrosomes; Drug loading content; Dynamic light scattering; FSD; Fully supramolecular dendrosomes; GPC; Gel permeation chromatography; IR; Infrared; Linear-dendritic copolymers; Mn; Molecular weight; NMR; Nuclear magnetic resonance; PG; PTX; Paclitaxel; Polyglycerol; Supramolecules; TEM; Transmission electron microscopy; UV; Ultraviolet; beta-cyclodextrin; critical aggregation concentration; drug loading efficiency; hyperbranched polyglycerol with a cyclodextrin core; lipid-like bi-chain polycaprolactone; β-CD; β-CD-g-PG