title: Bioinspired multiple-interaction model revealed in adsorption of low-density lipoprotein to surface containing saccharide and alkanesulfonate.
abstract: A new "multiple-interaction model" for low-density lipoprotein (LDL) adsorption to a specific surface containing saccharide and alkanesulfonate ligands is proposed. The model suggests that there are interactions of the saccharide component beyond electrostatic interactions of the alkanesulfonate component that both influence the LDL adsorption process. This concept of multiple interactions between saccharide and LDL was inspired by the similarity in structures of LDL receptors (LDLR), heparin, and heparans used in LDL-apheresis. The model was confirmed by SPR analysis by the adsorption maxima on SAM surfaces with different compositions of saccharide and alkanesulfonate and additionally by CD detection of the conformation of LDL when in contact with saccharide.
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization (Ministry of Education), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
authors.forename: Jörg
authors.initials: J
authors.lastname: Vienken
authors.forename: Zhi-Kang
authors.initials: ZK
authors.lastname: Xu
authors.forename: Thomas
authors.initials: T
authors.lastname: Groth
mesh_terms: D000327:Adsorption; D000476:Alkanesulfonates / Q000737:chemistry*; D006493:Heparin / Q000737:chemistry*; D008077:Lipoproteins, LDL / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D009844:Oligosaccharides / Q000737:chemistry*; D055672:Static Electricity; D020349:Surface Plasmon Resonance; D013499:Surface Properties
chemical_list: D000476:Alkanesulfonates; D008077:Lipoproteins, LDL; D009844:Oligosaccharides; D006493:Heparin