title: [Electron paramagnetic resonance study of blood of anemic patients with urological cancer].
abstract: Changes in Fe(3+)-transferrin (Fe(3+)-Tf) and Cu(2+)-ceruloplasmin (Cu(2+)-Cp) concentrations in venous blood sampled from anemic patients with urinary bladder and kidney cancer in I-IV stages were investigated using electron paramagnetic resonance spectroscopy. It was established that at malignancy-associated anemia the paramagnetic Fe3+ ion concentration in transferrin is below a norm, while in anemic non-oncology patients the Tf iron saturation is normal. Moreover, in patients with malignancy-associated anemia the Cu(2+)-Cp average value is nearly twice as large as that for healthy volunteers (confidence probability P). It was shown that simultaneous EPR measuring of paramagnetic centers (such as Fe(3+)-Tf and Cu(2+)-Cp) in blood of anemic patients can be used as a biomarker for urological cancer diagnosis even at early stages of the growth of a malignant tumor.
authors.forename: M I
authors.initials: MI
authors.lastname: Ibragimova
authors.forename: V N
authors.initials: VN
authors.lastname: Chushnikov
authors.forename: V N
authors.initials: VN
authors.lastname: Moiseev
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Petukhov
authors.forename: E P
authors.initials: EP
authors.lastname: Zheglov
authors.forename: G V
authors.initials: GV
authors.lastname: Cherepnev
mesh_terms: D000740:Anemia / Q000097:blood* / Q000150:complications; D014408:Biomarkers, Tumor / Q000097:blood; D002570:Ceruloplasmin / Q000032:analysis; D003300:Copper / Q000097:blood*; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D007501:Iron / Q000097:blood*; D007680:Kidney Neoplasms / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D009367:Neoplasm Staging; D014168:Transferrin / Q000032:analysis; D014571:Urologic Neoplasms / Q000097:blood* / Q000150:complications
chemical_list: D014408:Biomarkers, Tumor; D014168:Transferrin; D003300:Copper; D007501:Iron; D002570:Ceruloplasmin