title: pH-Switchable macroscopic assembly through host-guest inclusion.
abstract: A novel pH-switchable macroscopic assembly is reported using alginate-based hydrogels functionalized with host (α-cyclodextrin, αCD) and guest (diethylenetriamine, DETA) moieties. Since the interaction of αCD and DETA is pH sensitive, the host hydrogel and guest hydrogel could adhere together when the pH is 11.5 and separate when the pH is 7.0. Furthermore, this pH-controlled adhesion and dissociation shows a good reversibility. The host and guest polymers have good biocompatibility; therefore, this pH-sensitive macroscopic assembly shows great potential in biotechnological and biomedical applications.
authors.affiliation: State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China.
authors.forename: Qi-Juan
authors.initials: QJ
authors.lastname: Yuan
authors.forename: Yi-Fu
authors.initials: YF
authors.lastname: Wang
authors.forename: Jian-Hu
authors.initials: JH
authors.lastname: Li
authors.forename: Bang-Jing
authors.initials: BJ
authors.lastname: Li
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000464:Alginates / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008422:Materials Testing; D011073:Polyamines / Q000737:chemistry*; D047391:alpha-Cyclodextrins / Q000737:chemistry*
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D020100:Hydrogels; D011073:Polyamines; D047391:alpha-Cyclodextrins; C005391:diethylenetriamine; D020723:Glucuronic Acid; C032613:alpha-cyclodextrin
keywords: cyclodextrin; host-guest systems; macroscopic assembly; pH sensitive