title: [Metabolic abnormalities in young offsprings of parents with essential hypertension].
abstract: The familiar history of hypertension in healthy young offsprings is associated with hyperinsulinemia, which could lead to increased serum cortisol, resulting in renal endothelial damage and the presence of microalbuminuria. The aim of this study was to evaluate, in healthy young offsprings of hypertensive parents, association between insulin levels, serum cortisol and microalbuminuria attending to its relationship with increased cardiovascular risk. We performed a cross-sectional correlational study in Santa Fe, Argentina, including 145 healthy individuals aged over 18 years, allocated to two groups: those with a history of essential hypertensive parents (study group) and those without such history (control group). We evaluated fasting serum insulin, cortisol, and microalbuminuria levels in the first morning urine. The mean age was 20 ± 2.9 years, and 58% were women. The study group included 48% (n = 69) of the sample. 4.8% had insulin resistance, microalbuminuria 13.8% and 52% hipercortisolinemia, with no significant differences in serum insulin, cortisol, or microalbuminuria between groups. No correlation was found between these variables. In this study there was no association between a history of first degree hypertension and impaired insulin or cortisol homoeostasis.
authors.affiliation: Servicio de Clínica Médica, Hospital J. B. Iturraspe. mvicco@santafe-conicet.gov.ar
authors.forename: Miguel H
authors.initials: MH
authors.lastname: Vicco
authors.forename: Luz
authors.initials: L
authors.lastname: Rodeles
authors.forename: Lucía I
authors.initials: LI
authors.lastname: César
authors.forename: Franco
authors.initials: F
authors.lastname: Ferini
authors.forename: Catalina
authors.initials: C
authors.lastname: Dorigo
authors.forename: Héctor M
authors.initials: HM
authors.lastname: Musacchio
mesh_terms: D000419:Albuminuria / Q000097:blood* / Q000150:complications; D001118:Argentina; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D006946:Hyperinsulinism / Q000097:blood / Q000150:complications; D006973:Hypertension / Q000097:blood / Q000235:genetics*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D010290:Parents; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007328:Insulin; D006854:Hydrocortisone
keywords: heredity and hypertension; hypertension; microalbuminuria; serum cortisol