title: PLA/PEG-PPG-PEG/dexamethasone implant prepared by hot-melt extrusion for controlled release of immunosuppressive drug to implantable medical devices, Part 2: in vivo evaluation.
abstract: Hot-melt extrusion (HME) plays an important role in preparing implants as local drug delivery systems in pharmaceutical fields. Here, a new PLA/PEG-PPG-PEG/Dexamethasone (PLA/F68/Dex) implant prepared by HME has been developed. Importantly, the implant was successfully achieved to control release of immunosuppressive drug to an implanted device. In particular, this implant has not been reported previously in pharmaceutical fields. FTIR and XRD were adopted to investigate the properties of the samples. The in vivo release study showed that the maximum value of Dex release from the implants was approximately 50% at 1 month. The in vivo degradation behavior was determined by UV spectrophotometer and scanning electron microscopy studies, and the weight loss rate of the implants were up to 25% at 1 month. Furthermore, complete blood count (CBC) test, serum chemistry and major organs were performed, and there is no significant lesion and side effects observed in these results. Therefore, the results elucidated that the new PLA/F68/Dex implant prepared by HME could deliver an immunosuppressive drug to control the inflammatory reaction at the implant site.
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
authors.forename: DeXia
authors.initials: D
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Guo
authors.forename: Xin
authors.initials: X
authors.lastname: Deng
authors.forename: RangRang
authors.initials: R
authors.lastname: Fan
authors.forename: QingFa
authors.initials: Q
authors.lastname: Guo
authors.forename: Min
authors.initials: M
authors.lastname: Fan
authors.forename: Jian
authors.initials: J
authors.lastname: Liang
authors.forename: Feng
authors.initials: F
authors.lastname: Luo
authors.forename: ZhiYong
authors.initials: Z
authors.lastname: Qian
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis; D003907:Dexamethasone / Q000008:administration & dosage / Q000138:chemical synthesis*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006358:Hot Temperature; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000138:chemical synthesis*; D015918:Infusion Pumps, Implantable; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000138:chemical synthesis*; D011409:Propylene Glycols / Q000008:administration & dosage / Q000138:chemical synthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014961:X-Ray Diffraction
chemical_list: D003692:Delayed-Action Preparations; D007166:Immunosuppressive Agents; D011409:Propylene Glycols; C528875:poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) copolymer; D011092:Polyethylene Glycols; D003907:Dexamethasone