title: Prevalence of Toxoplasma gondii parasite infection among people who died due to sudden death in the capital city of Warsaw and its vicinity.
abstract: BACKGROUND
  It has recently been shown that the behavioural effects resulting from latent T. gondii infection in immunocompetent people could pose as a threat to their welfare. AIM. The aim of the study was to evaluate the prevalence of T. gondii infection in a group of people who died suddenly in Warsaw and its vicinity.
  
  
  METHODS
  The studied group (n = 169 people) included 42 road traffic accident victims who were driving a vehicle (bicycle (n = 6), a motorbike (n = 3), a motorcycle (n = 13), a car (n = 20)) prior to sudden death and 41 people whose death resulted from suicide. Blood samples were collected post-mortem and examined for the presence of T. gondii, IgG antibodies and ethyl alcohol.
  
  
  RESULTS
  Of the 169 people tested, T. gondii IgG antibodies were found in the serum of 93 (55%) of which 25 (59.5%) were drivers and 26 (63.4%) people who died as a result of suicide. With respect to the prevalence of T. gondii infection no statistically significant differences were found between the study (61.4%) and control group (49.4%); (p = 0.09). A statistically significant result was recorded in the 38-58 age group between suicide and control groups (71.4% vs. 44.4%; p < 0.05). Positive test results for the presence of ethyl alcohol in the blood were reported among 49.7% of the studied population: 25.7% among drivers, 67.6% among suicides and 51.8% in the control group. To a statisctically siginificant degree, IgG T. gondii antibodies were found to occur more frequently in people with positive blood alcohol test results among suicides (72% vs. 50%; p < 0.05) and among the control group (60% vs. 40%; p < 0.05) than in their equivalents with negative test results.
  
  
  CONCLUSIONS
  Our work confirmed the usefulness of serologically testing samples collected post-mortem for epidemiological purposes. The small size of the study group made it impossible to evaluate the potential associations between exposure to T. gondii infection and the probability of sudden death. The significance of Toxoplasma gondii infection as a risk factor for self-destructive behaviour merits further study.
authors.affiliation: Department of Forensic Medicine of Medical University of Warsaw, Poland. dorotea_7@poczta.onet.pl
authors.forename: Dorota
authors.initials: D
authors.lastname: Samojłowicz
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Borowska-Solonynko
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Gołab
mesh_terms: D000328:Adult; D000913:Antibodies, Protozoan / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015984:Causality; D002423:Cause of Death; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D013405:Suicide / Q000706:statistics & numerical data*; D014123:Toxoplasmosis / Q000175:diagnosis* / Q000453:epidemiology* / Q000276:immunology; D014505:Urban Population / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D000913:Antibodies, Protozoan; D015415:Biomarkers