title: Eosinophilia associated with bupropion.
abstract: METHODS
  A 48-year-old woman started treatment with bupropion 150 mg once daily for depressive symptoms. After 19 days she presented to her family physician complaining of myalgia and non-productive cough. The physical examination was normal and laboratory investigations showed an eosinophil count of 4.7 × 10(9)/L (0-0.5). The results of a basal test before to bupropion intake were within normal range including eosinophils (0.2 × 10(9)/L). After ruling out other causes of eosinophilia, the physician decided to gradually discontinue bupropion, and a marked decrease in absolute eosinophil count was subsequently observed.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the third published case of bupropion-related eosinophilia. Although, in light of the case presented, the prevalence of this adverse effect seems to be low, an awareness that bupropion can be a potential cause of eosinophilia may lead to the avoidance of unnecessary diagnostic tests or referral to other specialists.
authors.affiliation: Basque Country Pharmacovigilance Unit, Hospital Galdakao-Usansolo, Barrio Labeaga s/n, 48960, Galdakao, Bizkaia, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: García
authors.forename: Borja
authors.initials: B
authors.lastname: Ruiz
authors.forename: Carmelo
authors.initials: C
authors.lastname: Aguirre
authors.forename: Esther
authors.initials: E
authors.lastname: Etxegarai
authors.forename: Unax
authors.initials: U
authors.lastname: Lertxundi
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D016642:Bupropion / Q000009:adverse effects* / Q000627:therapeutic use; D003371:Cough / Q000209:etiology; D003866:Depressive Disorder / Q000188:drug therapy; D004802:Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D063806:Myalgia / Q000209:etiology
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion