title: Immunotherapy with artificial adjuvant vector cells: Harnessing both arms of the immune response.
abstract: Both innate and adaptive immunity underpin cancer immunosurveillance. To stimulate both these arms of the immune system, we used allogeneic cells loaded with natural killer T (NKT) cell ligands and expressing tumor-associated antigens, resulting in NKT cell activation, dendritic-cell maturation and ultimately in the elicitation of adaptive T-cell responses. This approach holds great promise for the development of novel anticancer immunotherapies.
authors.affiliation: Research Unit for Cellular Immunotherapy; The Institute of Physical and Chemical Research (RIKEN); Research Center for Allergy and Immunology (RCAI); Yokohama, Japan.
authors.forename: Shin-Ichiro
authors.initials: SI
authors.lastname: Fujii
authors.forename: Kanako
authors.initials: K
authors.lastname: Shimizu
keywords: adjuvant effects; cross-presentation; dendritic cells; iNKT cells; α-galactosylceramide