title: Influence of surface chemistry on particle internalization into giant unilamellar vesicles.
abstract: Cellular uptake of materials plays a key role in their biomedical applications. In this work, based on the cell-mimic giant unilamellar vesicles (GUVs) and a novel type of microscale materials consisting of stimuli-responsive poly(N-isopropylacrylamide) microgel particles and the incorporated lipids, the influence of particle surface chemistry, including hydrophobic/hydrophilic property and lipid decorations, on the adsorption and consequent internalization of particles into GUVs was investigated. It is found that the decoration of particle surface with lipids facilitates the adsorption of particles on GUV membrane. After that, the hydrophobic property of particle surface further triggers the internalization of particles into GUVs. These results demonstrate the importance of surface properties of particles on their interactions with lipid membranes and are helpful to the understanding of cellular uptake mechanism.
authors.affiliation: Center for Soft Condensed Matter Physics and Interdisciplinary Research, Soochow University, Suzhou, 215006, PR China.
authors.forename: Jiaojiao
authors.initials: J
authors.lastname: Liu
authors.forename: Naiyan
authors.initials: N
authors.lastname: Lu
authors.forename: Jingliang
authors.initials: J
authors.lastname: Li
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Weng
authors.forename: Bing
authors.initials: B
authors.lastname: Yuan
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Ma
mesh_terms: D057927:Hydrophobic and Hydrophilic Interactions; D018613:Microscopy, Confocal; D064347:Microscopy, Electrochemical, Scanning; D008962:Models, Theoretical; D013499:Surface Properties; D053835:Unilamellar Liposomes / Q000737:chemistry*
chemical_list: D053835:Unilamellar Liposomes