title: Systemic protein therapy for recessive dystrophic epidermolysis bullosa: how far are we from clinical translation?
abstract: In this issue, Woodley et al. report restoration of anchoring fibril formation and dermal-epidermal adherence in a murine model of recessive dystrophic epidermolysis bullosa (RDEB) by intravenous injection of recombinant human type VII collagen. This work follows a previous report by the same group of the surprising capability of intradermally injected type VII collagen protein to reverse RDEB, and it opens new therapeutic avenues.
authors.affiliation: University Paris Descartes Sorbonne Paris Cité, Imagine Institute, Paris, France. alain.hovnanian@inserm.fr
authors.forename: Alain
authors.initials: A
authors.lastname: Hovnanian
mesh_terms: D000818:Animals; D024143:Collagen Type VII / Q000494:pharmacology* / Q000627:therapeutic use*; D016108:Epidermolysis Bullosa Dystrophica / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D012867:Skin / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy*
chemical_list: D024143:Collagen Type VII