title: Lack of association between IL-23R gene polymorphisms and systemic lupus erythematosus in a Chinese population.
abstract: OBJECTIVE
  The aim to this study was to investigate the association between the single-nucleotide polymorphisms (SNPs) of interleukin (IL)-23 receptor gene and systemic lupus erythematosus (SLE) in a Chinese population.
  
  
  METHODS
  A case-control study was performed to investigate the associations of SNPs in IL-23R gene (rs10889677 and rs1884444) with susceptibility to SLE in 521 Chinese SLE patients and 527 normal controls. The chi-square test and unconditional Logistic regression were used to analysis by SPSS 10.1 software.
  
  
  RESULTS
  No significant differences were detected for the distribution of allele and genotype frequencies of these two SNPs between patients and controls as well as SLE patients with nephritis (LN) and those without nephritis.
  
  
  CONCLUSIONS
  The findings suggest that the polymorphisms of IL-23R gene might not contribute to the susceptibility of SLE in the Chinese population.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, People's Republic of China.
authors.forename: Gui-Mei
authors.initials: GM
authors.lastname: Chen
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Feng
authors.forename: Qian-Ling
authors.initials: QL
authors.lastname: Ye
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Han
authors.initials: H
authors.lastname: Cen
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Peng
authors.forename: Mo
authors.initials: M
authors.lastname: Zhou
authors.forename: Rui-Xue
authors.initials: RX
authors.lastname: Leng
authors.forename: Yin-Guang
authors.initials: YG
authors.lastname: Fan
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Tao
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics*; D055815:Young Adult
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin