title: Palladium-catalyzed oxidative cross-coupling of N-tosylhydrazones with indoles: synthesis of N-vinylindoles.
abstract: A general and efficient palladium-catalyzed oxidative cross-coupling reaction of N-tosylhydrazones with indoles providing N-vinylindoles has been developed. The reaction proceeds smoothly with various indoles and N-tosylhydrazones in a stereocontrolled manner, and a wide variety of N-vinylindoles were obtained up to 99% yields for 26 examples.
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University , Xiamen, 361021, China.
authors.forename: Xiaobao
authors.initials: X
authors.lastname: Zeng
authors.forename: Guolin
authors.initials: G
authors.lastname: Cheng
authors.forename: Jinhai
authors.initials: J
authors.lastname: Shen
authors.forename: Xiuling
authors.initials: X
authors.lastname: Cui
mesh_terms: D002384:Catalysis; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D058451:Oxidative Coupling; D010165:Palladium / Q000737:chemistry*; D014105:Tosyl Compounds / Q000737:chemistry; D014753:Vinyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006835:Hydrazones; D007211:Indoles; D014105:Tosyl Compounds; D014753:Vinyl Compounds; C569210:vinyl iodide; D010165:Palladium