title: Analytical methodologies for the determination of endocrine disrupting compounds in biological and environmental samples.
abstract: Endocrine-disruptor compounds (EDCs) can mimic natural hormones and produce adverse effects in the endocrine functions by interacting with estrogen receptors. EDCs include both natural and synthetic chemicals, such as hormones, personal care products, surfactants, and flame retardants, among others. EDCs are characterised by their ubiquitous presence at trace-level concentrations and their wide diversity. Since the discovery of the adverse effects of these pollutants on wildlife and human health, analytical methods have been developed for their qualitative and quantitative determination. In particular, mass-based analytical methods show excellent sensitivity and precision for their quantification. This paper reviews recently published analytical methodologies for the sample preparation and for the determination of these compounds in different environmental and biological matrices by liquid chromatography coupled with mass spectrometry. The various sample preparation techniques are compared and discussed. In addition, recent developments and advances in this field are presented.
authors.affiliation: Departamento de Química, Universidad de Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain.
authors.forename: Zoraida
authors.initials: Z
authors.lastname: Sosa-Ferrera
authors.forename: Cristina
authors.initials: C
authors.lastname: Mahugo-Santana
authors.forename: José Juan
authors.initials: JJ
authors.lastname: Santana-Rodríguez
mesh_terms: D053000:Analytic Sample Preparation Methods; D000818:Animals; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation / Q000379:methods*; D052244:Endocrine Disruptors / Q000032:analysis* / Q000737:chemistry; D004784:Environmental Monitoring / Q000295:instrumentation / Q000379:methods*; D004785:Environmental Pollutants / Q000032:analysis* / Q000737:chemistry; D006801:Humans
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants