title: Natural killer expansion, human leukocyte antigens-E expression and CD14(+) CD56(+) monocytes in a myelodysplastic syndrome patient.
abstract: Myelodysplastic syndromes (MDS) are clonal disorders characterized by ineffective hematopoiesis and possible evolution to acute leukemia. Occurrence of stem cell defects and of immune-mediated mechanisms was evidenced as relevant for pathophysiology of MDS. Here, we described one case of MDS patient carrying CD14(+) CD56(+) monocytes in bone marrow (BM), in the presence of a defective human leukocyte antigen (HLA)-E expression on peripheral blood (PB) cells and of natural killer (NK) cell expansion in PB and BM. The defective HLA-E expression and the NK expansion are proposed to be relevant for the pathogenesis of myelodysplasia in those patients showing CD14(+) CD56(+) monocytes in BM.
authors.affiliation: Department of Science, University of Basilicata, Potenza, Italy.|Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Terrazzano
authors.affiliation: Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Rubino
authors.affiliation: Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.
authors.forename: Anna Teresa
authors.initials: AT
authors.lastname: Palatucci
authors.affiliation: Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Giovazzino
authors.affiliation: Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Annunziatella
authors.affiliation: Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.
authors.forename: Orsola
authors.initials: O
authors.lastname: Vitagliano
authors.affiliation: Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Alfinito
authors.affiliation: Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Ruggiero
mesh_terms: D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism; D019002:CD56 Antigen / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008297:Male; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism*; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D000097625:HLA-E Antigens
chemical_list: D015703:Antigens, CD; D019002:CD56 Antigen; D015395:Histocompatibility Antigens Class I; D018950:Lipopolysaccharide Receptors; D000097625:HLA-E Antigens
keywords: CD94/NKG2 receptors; human leukocyte antigens-E; immune-mediated etiopathogenesis; myelodysplastic syndromes; natural killer