title: Mechanical unfolding of long human telomeric RNA (TERRA).
abstract: We report the first single molecule investigation of TERRA molecules. By using optical-tweezers and other biophysical techniques, we have found that long RNA constructions of up to 25 GGGUUA repeats form higher order structures comprised of single parallel G-quadruplex blocks, which unfold at lower forces than their DNA counterparts.
authors.affiliation: Instituto de Química Física Rocasolano, CSIC, C/Serrano 119, 28006 Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Garavís
authors.forename: Rebeca
authors.initials: R
authors.lastname: Bocanegra
authors.forename: Elías
authors.initials: E
authors.lastname: Herrero-Galán
authors.forename: Carlos
authors.initials: C
authors.lastname: González
authors.forename: Alfredo
authors.initials: A
authors.lastname: Villasante
authors.forename: J Ricardo
authors.initials: JR
authors.lastname: Arias-Gonzalez
mesh_terms: D054856:G-Quadruplexes; D006801:Humans; D012313:RNA / Q000737:chemistry* / Q000235:genetics; D059370:RNA Folding; D012091:Repetitive Sequences, Nucleic Acid; D016615:Telomere / Q000235:genetics
chemical_list: D012313:RNA