title: [Components of plastic disrupt the function of the nervous system].
abstract: Development of the chemical industry leads to the development of new chemical compounds, which naturally do not exist in the environment. These chemicals are used to reduce flammability, increase plasticity, or improve solubility of other substances. Many of these compounds, which are components of plastic, the new generation of cosmetics, medical devices, food packaging and other everyday products, are easily released into the environment. Many studies have shown that a major lipophilicity characterizes substances such as phthalates, BPA, TBBPA and PCBs. This feature allows them to easily penetrate into living cells, accumulate in the tissues and the organs, and affect human and animal health. Due to the chemical structures, these compounds are able to mimic some endogenous hormones such as estradiol and to disrupt the hormone homeostasis. They can also easily pass the placental barrier and the blood-brain barrier. As numerous studies have shown, these chemicals disturb the proper functions of the nervous system from the earliest moments of life. It has been proven that these compounds affect neurogenesis as well as the synaptic transmission process. As a consequence, they interfere with the formation of the sex of the brain, as well as with the learning processes, memory and behavior. Additionally, the cytotoxic and pro-apoptotic effect may cause neurodegenerative diseases. This article presents the current state of knowledge about the effects of phthalates, BPA, TBBPA, and PCBs on the nervous system.
authors.affiliation: Pracownia Biotechnologii i Genomiki, Katedra Trzody Chlewnej i Małych Przeżuwaczy, Wydziału Hodowli i Biologii Zwierząt, Uniwersytet Rolniczy w Krakowie, Krakow.
authors.forename: Konrad Andrzej
authors.initials: KA
authors.lastname: Szychowski
authors.forename: Anna Katarzyna
authors.initials: AK
authors.lastname: Wójtowicz
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity; D001812:Blood-Brain Barrier / Q000378:metabolism; D002617:Chemical Industry; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D009420:Nervous System / Q000187:drug effects* / Q000378:metabolism*; D010636:Phenols / Q000633:toxicity; D010795:Phthalic Acids / Q000633:toxicity; D010969:Plastics / Q000633:toxicity*; D011075:Polybrominated Biphenyls / Q000633:toxicity; D011078:Polychlorinated Biphenyls / Q000633:toxicity; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; D010795:Phthalic Acids; D010969:Plastics; D011075:Polybrominated Biphenyls; D011078:Polychlorinated Biphenyls; C020806:tetrabromobisphenol A; C006780:bisphenol A; D000098826:Bisphenol A Compounds