title: Risk factors for the occurrence of insulinoma: a case-control study.
abstract: BACKGROUND
  The etiology of insulinoma is poorly understood. Few studies investigated the possible roles of environmental factors and lifestyle in the pathogenesis of insulinoma. The aim of this study is to identify risk factors associated with occurrence of insulinoma in the Chinese population.
  
  
  METHODS
  This study consisted of 196 patients with insulinoma and 233 controls. Demographic information of the patients and controls and risk factors of the disease were analyzed. Univariate and unconditional multivariable logistic regression analyses were made to estimate odds ratios (ORs) and possible risk factors.
  
  
  RESULTS
  Approximately 68.88% (135/196) of the patients were from rural areas in contrast to 10.30% (24/233) of the controls (P<0.0001). This difference was confirmed by the multivariate analysis (OR=4.950; 95% CI: 2.928-8.370). Family history of pancreatic endocrine tumor (OR=16.754; 95% CI: 2.125-132.057) and other cancers (OR=2.360; 95% CI: 1.052-5.291) was also related to a high-risk population of insulinoma.
  
  
  CONCLUSIONS
  Rural residents or people who have a family history of pancreatic endocrine tumor and other cancers are a high-risk population of insulinoma.
authors.affiliation: Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. zhao8028@263.net
authors.forename: Han-Xiang
authors.initials: HX
authors.lastname: Zhan
authors.forename: Lin
authors.initials: L
authors.lastname: Cong
authors.forename: Yu-Pei
authors.initials: YP
authors.lastname: Zhao
authors.forename: Tai-Ping
authors.initials: TP
authors.lastname: Zhang
authors.forename: Ge
authors.initials: G
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007340:Insulinoma / Q000453:epidemiology* / Q000235:genetics; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000235:genetics; D010375:Pedigree; D012111:Residence Characteristics; D012189:Retrospective Studies; D012307:Risk Factors; D012423:Rural Health; D014504:Urban Health; D055815:Young Adult