title: Association between caffeine intake and age at onset in Huntington's disease.
abstract: Habitual consumption of caffeine, a non-selective adenosine receptor (AR) antagonist, has been suggested to be beneficial in Parkinson's and Alzheimer's diseases. Experimental evidence support that ARs play a role in Huntington's disease (HD) raising the hypothesis that caffeine may be a life-style modifier in HD. To determine a possible relationship between caffeine consumption and age at onset (AAO) in HD, we retrospectively assessed caffeine consumption in 80 HD patients using a dietary survey and determined relationship with AAO. Following adjustment for gender, smoking status and CAG repeat length, caffeine consumption greater than 190mg/day was significantly associated with an earlier AAO. These data support an association between habitual caffeine intake and AAO in HD patients, but further studies are warranted to understand the link between these variables.
authors.affiliation: Department of Neurology and Movement Disorders, Roger Salengro University Hospital, Lille, France. clemence.simonin@chru-lille.fr
authors.forename: Clémence
authors.initials: C
authors.lastname: Simonin
authors.forename: Cécile
authors.initials: C
authors.lastname: Duru
authors.forename: Julia
authors.initials: J
authors.lastname: Salleron
authors.forename: Pascale
authors.initials: P
authors.lastname: Hincker
authors.forename: Perrine
authors.initials: P
authors.lastname: Charles
authors.forename: Arnaud
authors.initials: A
authors.lastname: Delval
authors.forename: Katia
authors.initials: K
authors.lastname: Youssov
authors.forename: Sylvie
authors.initials: S
authors.lastname: Burnouf
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Azulay
authors.forename: Christophe
authors.initials: C
authors.lastname: Verny
authors.forename: Clarisse
authors.initials: C
authors.lastname: Scherer
authors.forename: Christine
authors.initials: C
authors.lastname: Tranchant
authors.forename: Cyril
authors.initials: C
authors.lastname: Goizet
authors.forename: Sabrina
authors.initials: S
authors.lastname: Debruxelles
authors.forename: Luc
authors.initials: L
authors.lastname: Defebvre
authors.forename: Bernard
authors.initials: B
authors.lastname: Sablonnière
authors.forename: Monique
authors.initials: M
authors.lastname: Romon-Rousseaux
authors.forename: Luc
authors.initials: L
authors.lastname: Buée
authors.forename: Alain
authors.initials: A
authors.lastname: Destée
authors.forename: Olivier
authors.initials: O
authors.lastname: Godefroy
authors.forename: Alexandra
authors.initials: A
authors.lastname: Dürr
authors.forename: Bernhard
authors.initials: B
authors.lastname: Landwehrmeyer
authors.forename: Anne-Catherine
authors.initials: AC
authors.lastname: Bachoud-Levi
authors.forename: Florence
authors.initials: F
authors.lastname: Richard
authors.forename: David
authors.initials: D
authors.lastname: Blum
authors.forename: Pierre
authors.initials: P
authors.lastname: Krystkowiak
mesh_terms: D000328:Adult; D017668:Age of Onset; D002110:Caffeine / Q000009:adverse effects*; D040503:Coffea / Q000378:metabolism; D005260:Female; D005602:France; D006801:Humans; D006816:Huntington Disease / Q000139:chemically induced* / Q000453:epidemiology* / Q000235:genetics; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D057566:Self Report; D018709:Statistics, Nonparametric; D019680:Trinucleotide Repeat Expansion / Q000235:genetics
chemical_list: D002110:Caffeine
keywords: Adenosine receptors; Caffeine; Huntington's disease