title: This message will self-destruct: NMD regulates axon guidance.
abstract: The navigation of axons to their final destination can involve a sequence of steps that require different sets of guidance receptors. In this issue, Colak et al. show that regulated intra-axonal protein synthesis coupled to nonsense-mediated mRNA decay (NMD) controls a switch in Robo3.2 expression that is critical for navigation.
authors.affiliation: Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Preitner
authors.forename: Jie
authors.initials: J
authors.lastname: Quan
authors.forename: John G
authors.initials: JG
authors.lastname: Flanagan
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000378:metabolism*; D020439:Growth Cones / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D059365:Nonsense Mediated mRNA Decay; D011956:Receptors, Cell Surface; D013116:Spinal Cord / Q000196:embryology*; D000097905:Roundabout Proteins
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; C118348:Robo3 protein, mouse; D000097905:Roundabout Proteins