title: HHARI is one HECT of a RING.
abstract: E3 ubiquitin ligases are the last of an enzyme trio that covalently modifies proteins with ubiquitin, facilitating various cellular functions. In this issue of Structure, Duda and colleagues provide the structural basis for the autoinhibited Ariadne-family of E3-ubiquitin ligases.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Davies
authors.forename: Chittaranjan
authors.initials: C
authors.lastname: Das
mesh_terms: D002352:Carrier Proteins / Q000737:chemistry*; D006801:Humans; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry*
chemical_list: D002352:Carrier Proteins; C419193:ARIH1 protein, human; D044767:Ubiquitin-Protein Ligases