title: Pediatric pharmacokinetics.
abstract: After reading this article, the reader should be able to 1. Realize that volume of distribution, elimination clearance, and elimination half-life are crucial parameters of pharmacokinetics that must be understood to determine clinical pharmacologic decisions.2. Know that drug disposition is a complicated process of absorption, distribution,metabolism, and excretion. 3. Understand that any abnormality in absorption, distribution, metabolism, and/or excretion can potentially affect the efficacy or toxicity of a drug. 4. Understand that the anatomical and physiologic changes during development must be considered in predicting age-dependent changes in drug disposition.
authors.affiliation: Section of Cardiology and Division of Clinical Pharmacology and Medical Toxicology, Department of Pediatrics, Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Wagner
authors.forename: Susan M
authors.initials: SM
authors.lastname: Abdel-Rahman
mesh_terms: D000042:Absorption; D001682:Biological Availability; D002648:Child; D006207:Half-Life; D006801:Humans; D004364:Pharmaceutical Preparations; D010599:Pharmacokinetics; D014018:Tissue Distribution
chemical_list: D004364:Pharmaceutical Preparations