title: Trp64Arg (rs4994) polymorphism of β3-adrenergic receptor gene is associated with hyperuricemia in a Chinese male population.
abstract: BACKGROUND
  β3-Adrenergic receptor (β3-AR) gene is associated with insulin resistance and may affect serum uric acid levels. Our aim was to determine the possible association between β3-AR gene Trp64Arg polymorphism (rs4994) and hyperuricemia in a Chinese male population.
  
  
  METHODS
  A total of 410 hyperuricemic and 420 normouricemic male subjects were genotyped in this study. The genotypic and allelic frequencies were compared between the two groups. Body mass index (BMI), waist to hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum uric acid, urea nitrogen, creatinine, triglyceride, total cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) and fasting plasma glucose (FPG) were determined.
  
  
  RESULTS
  The frequencies of CC genotype and C allele for Trp64Arg polymorphism were higher in hyperuricemic group than in normouricemic group (p<0.01 and p<0.05, respectively). In both hyperuricemic and normouricemic groups, subjects with mutated C allele of Trp64Arg polymorphism showed significantly higher average uric acid levels than TT genotype carriers (p<0.01 and p<0.01, respectively). Univariate and multivariate logistic regression showed that carrier of mutated C allele of Trp64Arg polymorphism was significantly associated with hyperuricemia occurrence (p=0.003, OR=1.587, 95% CI 1.175-2.145 and p=0.003, OR=1.676, 95% CI 1.051-3.617).
  
  
  CONCLUSIONS
  Trp64Arg polymorphism was associated with hyperuricemia in a Chinese male population and should be an independent risk factor for hyperuricemia.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Huang
authors.forename: Liu-Fu
authors.initials: LF
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Cheng
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Si
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
chemical_list: D022702:Receptors, Adrenergic, beta-3; D014527:Uric Acid