title: Chemiluminescence determination of trimetazidine via inducing the aggregation of gold nanoparticles.
abstract: A simple, rapid and sensitive chemiluminescence (CL) method combined with flow injection analysis was developed for the determination of trimetazidine. Trimetazidine was found to significantly increase the CL signal arising from N-bromosuccinimide-luminol reaction in the presence of gold nanoparticles. The enhanced CL intensity was proportional to trimetazidine concentration in the range of 0.01-5.0 μg/mL, with a limit of detection (3 sb) of 6.7 ng/mL. The relative standard deviation was 2.8% for 11 repetitive measurements of 0.1 μg/mL trimetazidine solution. The practicality of the method was evaluated by determining trimetazidine in pharmaceutical formulations and in spiked human serum samples. Moreover, the possible CL reaction mechanism was also discussed.
authors.affiliation: Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Quan
authors.forename: Jianxiu
authors.initials: J
authors.lastname: Du
authors.forename: Mei
authors.initials: M
authors.lastname: Liu
mesh_terms: D017022:Flow Injection Analysis / Q000379:methods; D006046:Gold / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D049449:Luminescence; D008163:Luminescent Measurements / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D014292:Trimetazidine / Q000032:analysis / Q000097:blood*; D014665:Vasodilator Agents / Q000032:analysis / Q000097:blood*
chemical_list: D004364:Pharmaceutical Preparations; D014665:Vasodilator Agents; D006046:Gold; D014292:Trimetazidine
keywords: Chemiluminescence; Gold nanoparticles; Trimetazidine