title: No association between MspI allele of the ADRA2A polymorphism and ADHD: meta-analysis of family-based studies.
abstract: There is evidence for a genetic contribution to attention-deficit hyperactivity disorder (ADHD), although no candidate genes have attained genome-wide significance to date. Given that the noradrenergic system has been implicated in ADHD, the gene for the α2-adrenergic receptor (ADRA2A) has been hypothesized to contribute to the pathogenesis of ADHD. The present investigation reports results from a meta-analysis of family-based studies that did not find a significant association between the MspI polymorphism of the ADRA2A gene and ADHD.
authors.affiliation: Department of Psychology, Yale University, New Haven, Connecticut, USA.
authors.forename: Nina D
authors.initials: ND
authors.lastname: Shiffrin
authors.forename: June
authors.initials: J
authors.lastname: Gruber
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Glatt
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
mesh_terms: D000483:Alleles; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D019003:Deoxyribonuclease HpaII / Q000235:genetics*; D005190:Family; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008957:Models, Genetic; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*
chemical_list: C547768:ADRA2A protein, human; D018341:Receptors, Adrenergic, alpha-2; D019003:Deoxyribonuclease HpaII