title: Site-specific cellular delivery of quantum dots with chemoselectively-assembled modular peptides.
abstract: Modular peptides displaying both quantum dot bioconjugation motifs and specific subcellular targeting domains were constructed using a chemoselective aniline-catalyzed hydrazone coupling chemistry. Peptides were ratiometrically assembled onto quantum dots to facilitate their specific delivery to either the plasma membrane, endosomes, the cytosol or the mitochondria of target cells.
authors.affiliation: Center for Bio/Molecular Science and Engineering, Code 6900, USA. James.delehanty@nrl.navy.mil
authors.forename: James B
authors.initials: JB
authors.lastname: Delehanty
authors.forename: Juan B
authors.initials: JB
authors.lastname: Blanco-Canosa
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Bradburne
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Susumu
authors.forename: Michael H
authors.initials: MH
authors.lastname: Stewart
authors.forename: Duane E
authors.initials: DE
authors.lastname: Prasuhn
authors.forename: Philip E
authors.initials: PE
authors.lastname: Dawson
authors.forename: Igor L
authors.initials: IL
authors.lastname: Medintz
mesh_terms: D000595:Amino Acid Sequence; D002462:Cell Membrane / Q000187:drug effects*; D016503:Drug Delivery Systems; D008928:Mitochondria / Q000187:drug effects; D010455:Peptides / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology*; D045663:Quantum Dots / Q000737:chemistry
chemical_list: D010455:Peptides