title: Subtype B was the dominant strain among HIV type 1 infections except for the population of men who have sex with men in Harbin City, China.
abstract: We sought to identify the prevalent subtypes and study the genetic variation of HIV-1 circulating in HIV infections in Harbin City, China. Forty-seven samples from the env V3-V4 region were successfully sequenced and analyzed, which involved thirty-one men who have sex with men (MSM), eight heterosexuals, seven former plasma donors (FPD)/blood transfusion recipients (BT), and one injection drug user (IDU). In all, 46.8% of CRF01_AE, 40.4% of subtype B, and 12.8% of CRF07_BC were identified. CRF01_AE (64.5%) was the dominant strain in MSM, and subtype B (81.2%) was the chief strain in other infected subjects except for the MSM population. Among all the genotypes, the B subtype possesses greater diversity of the tetramer on the tip of V3 loop than CRF07_BC and CRF01_AE, in which the peculiar GWGR was commonly found. Because nationwide there is a trend toward the increasing presence of CRF01_AE, a consecutive surveillance campaign was necessary among all HIV vulnerable populations in this locality.
authors.affiliation: Department of Epidemiology, Public Health College of Harbin Medical University, Harbin, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Shao
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Li
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Qing-Hai
authors.initials: QH
authors.lastname: Li
authors.forename: Hang
authors.initials: H
authors.lastname: Li
authors.forename: Man-Li
authors.initials: ML
authors.lastname: Chang
authors.forename: Chao-Qun
authors.initials: CQ
authors.lastname: Huang
authors.forename: Fu-Xiang
authors.initials: FX
authors.lastname: Wang
authors.forename: Bin-You
authors.initials: BY
authors.lastname: Wang
mesh_terms: D001483:Base Sequence; D001782:Blood Donors; D002681:China / Q000453:epidemiology; D055030:Drug Users; D015752:Genes, env; D014644:Genetic Variation; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D017423:Sequence Analysis, RNA; D012725:Sexual Behavior