title: [A case of systemic amyloidosis with cholangiectasis diagnosed by liver biopsy].
abstract: A 60-year-old man presented with fever and fatigue in a medical clinic and was given a diagnosis of cholangitis with mild cholangiectasis. The cholangiectasis remained even after treatment with an appropriate antibiotic agent. When the patient was transferred to our hospital for further examination, he was newly suffering from orthostatic hypotension and peripheral facial nerve palsy. Computed tomography (CT) scan revealed multiple low-density areas in the liver and intrahepatic bile duct dilatation. We performed percutaneous liver biopsy, and histopathological findings showed amyloid deposition around the portal vein. We diagnosed his condition as AL amyloidosis. Oral administration of melphalan and dexamethasone improved his clinical features and CT findings. We consider this case as rare in that the deposition of amyloid protein caused cholangiectasis.
authors.affiliation: Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan. yutakay@musashino.jrc.or.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kawano
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yasui
authors.forename: Kaoru
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Masaru
authors.initials: M
authors.lastname: Muraoka
authors.forename: Keisuke
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Hoshioka
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Tamaki
authors.forename: Tomoji
authors.initials: T
authors.lastname: Katoh
authors.forename: Takanori
authors.initials: T
authors.lastname: Hosokawa
authors.forename: Ken
authors.initials: K
authors.lastname: Ueda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakanishi
authors.forename: Jun
authors.initials: J
authors.lastname: Itakura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Asahina
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kurosaki
authors.forename: Namiki
authors.initials: N
authors.lastname: Izumi
mesh_terms: D000686:Amyloidosis / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D001706:Biopsy; D004108:Dilatation, Pathologic; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged