title: The chronergy of recombinant streptokinase thrombolysis in acute myocardial infarction.
abstract: The aim of this study was to explore the chronergy of intravenous recombinant streptokinase (r-SK) in patients with acute myocardial infarction (AMI). A total of 114 patients were divided into two groups according to the time of AMI onset: the morning onset (6:01-12:00, n=53) and non-morning onset (12:01-06:00, n=61) groups. The recanalization rate was recorded, as well as anticoagulant and fibrinolytic indices. Statistical analysis was performed to evaluate the recanalization rate following thrombolysis, as well as the anticoagulant and fibrinolytic activities. The recanalization rates following thrombolysis in the morning onset and non-morning onset groups were 60.4 and 82.0%, respectively (P<0.05). The level of plasminogen activator inhibitor-1 (PAI-1) antigen was significantly higher in the morning onset group compared with that in the non-morning onset group (P<0.05). This indicated a resistance to r-SK thrombolysis in the morning at the early stage of AMI, which possibly correlates with increased PAI-1 antigen levels and activity.
authors.affiliation: Second Department of Cardiology, General Hospital of North China Petroleum Administration;
authors.forename: Zhong-Ming
authors.initials: ZM
authors.lastname: Wang
authors.forename: Ya-Bing
authors.initials: YB
authors.lastname: Liu
authors.forename: Qi-Chen
authors.initials: QC
authors.lastname: Jin
authors.forename: Xue-Qi
authors.initials: XQ
authors.lastname: Wang
authors.forename: Meng
authors.initials: M
authors.lastname: Dai
authors.forename: Hui
authors.initials: H
authors.lastname: Shao
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Zhao
authors.forename: Qiu-Li
authors.initials: QL
authors.lastname: Dong
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Wang
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Zhang
authors.forename: Li-Cha
authors.initials: LC
authors.lastname: Kong
authors.forename: Shao-Yun
authors.initials: SY
authors.lastname: Liu
authors.forename: Dong-Ying
authors.initials: DY
authors.lastname: Wang
keywords: acute myocardial infarction; chronergy of onset; morning resistance to thrombolysis; thrombolytic therapy