title: Regulation of organismal proteostasis by transcellular chaperone signaling.
abstract: A major challenge for metazoans is to ensure that different tissues, each expressing distinctive proteomes, are nevertheless well protected at an organismal level from proteotoxic stress. We show that expression of endogenous metastable proteins in muscle cells, which rely on chaperones for proper folding, induces a systemic stress response throughout multiple tissues of C. elegans. Suppression of misfolding in muscle cells can be achieved not only by enhanced expression of HSP90 in muscle cells but as effectively by elevated expression of HSP90 in intestine or neuronal cells. This cell-nonautonomous control of HSP90 expression relies upon transcriptional feedback between somatic tissues that is regulated by the FoxA transcription factor PHA-4. This transcellular chaperone signaling response maintains organismal proteostasis when challenged by a local tissue imbalance in folding and provides the basis for organismal stress-sensing surveillance.
authors.affiliation: Department Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA.
authors.forename: Patricija
authors.initials: P
authors.lastname: van Oosten-Hawle
authors.forename: Robert S
authors.initials: RS
authors.lastname: Porter
authors.forename: Richard I
authors.initials: RI
authors.lastname: Morimoto
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D055785:Gene Knockdown Techniques; D018841:HSP90 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D018869:Heat-Shock Response; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000166:cytology; D032342:Muscle Cells / Q000378:metabolism; D009218:Myosins / Q000235:genetics / Q000378:metabolism; D017510:Protein Folding; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism*
chemical_list: D029742:Caenorhabditis elegans Proteins; C510188:DAF-21 protein, C elegans; D018841:HSP90 Heat-Shock Proteins; C113277:Pha-4 protein, C elegans; D015534:Trans-Activators; D009218:Myosins