title: Pluripotent hybrid stem cells from transgenic Huntington's disease monkey.
abstract: Huntington's disease (HD) is a devastating disease that currently has no cure. Transgenic HD monkeys have developed key neuropathological and cognitive behavioral impairments similar to HD patients. Thus, pluripotent stem cells derived from transgenic HD monkeys could be a useful comparative model for clarifying HD pathogenesis and developing novel therapeutic approaches, which could be validated in HD monkeys. In order to create personal pluripotent stem cells from HD monkeys, here we present a tetraploid technique for deriving pluripotent hybrid HD monkey stem cells.
authors.affiliation: Stem Cell and Developmental Biology 6, Genome Institute of Singapore, Genome, Singapore.
authors.forename: Chuti
authors.initials: C
authors.lastname: Laowtammathron
authors.forename: Anthony W S
authors.initials: AW
authors.lastname: Chan
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D018929:Cell Culture Techniques / Q000379:methods*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D002469:Cell Separation; D015925:Cryopreservation; D004210:Dissection; D004622:Embryo, Mammalian / Q000166:cytology; D005260:Female; D005333:Fetus / Q000196:embryology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006728:Hormones / Q000494:pharmacology; D006816:Huntington Disease / Q000473:pathology*; D006822:Hybrid Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008253:Macaca mulatta; D051379:Mice; D009865:Oocytes / Q000166:cytology; D039904:Pluripotent Stem Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D057891:Tetraploidy; D046509:Tissue Culture Techniques
chemical_list: D006728:Hormones