title: [Study on preparation of total flavones in Glechoma longituba sustained-release tablets and its in vitro release].
abstract: OBJECTIVE
  To study the preparation of total flavones in Glechoma longituba sustained-release tablets and evaluate its releasing features in vitro.
  
  
  METHODS
  Orthogonal experiment (L(9)3(4)) was used to optimize the process of preparation of total flavones in Glechoma longituba sustained-release tablets. Investigated the release effect in vitro of optimization test result.
  
  
  RESULTS
  The optimized prescription was HPMC-K4M and carbopol 934p account for 30% of the total tablet weight, their dosage ratio was 2: 1; Lactose as additives, 20% dosage; 5% PVP ethanol as adhesives, and compressed the wet granule of the materials into the total flavones in Glechoma longituba sustained-release tablets. The released profiles of the sustained-release tablets followed zero-order equation.
  
  
  CONCLUSIONS
  The sustained-release effect of total flavones in Glechoma longituba sustained-release tablets is good, the preparation craft is easy and feasible and worth widely promoting.
authors.affiliation: Liaoning Medical College, Jinzhou 121001, China. yutong8747@sina.com
authors.forename: Chun-Ling
authors.initials: CL
authors.lastname: Yuan
authors.forename: Liang
authors.initials: L
authors.lastname: Zhao
authors.forename: Ya-Juan
authors.initials: YJ
authors.lastname: Wang
mesh_terms: D000180:Acrylic Resins; D003692:Delayed-Action Preparations / Q000737:chemistry; D004355:Drug Stability; D000431:Ethanol / Q000737:chemistry; D005079:Excipients / Q000737:chemistry; D047309:Flavones / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D019686:Lamiaceae / Q000737:chemistry*; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D011145:Polyvinyls / Q000008:administration & dosage / Q000737:chemistry; D015203:Reproducibility of Results; D012995:Solubility; D013607:Tablets / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D005079:Excipients; D047309:Flavones; D011145:Polyvinyls; D013607:Tablets; C006912:carboxypolymethylene; D000431:Ethanol; D008747:Methylcellulose