title: A new steroidal glycoside from the seeds of Hyoscyamus niger.
abstract: A new steroidal glycoside hyoscyamoside G (1), together with two known analogues hyoscyamoside E (2) and hyoscyamoside F1 (3), was isolated from the seeds of Hyoscyamus niger. The structure of 1 was established as (22R,24Z)-1α,3β,7β,22,26-pentakishydroxylergost-22-O-β-d-gulcopyranosyl-5,24-diene-26-O-β-d-glucopyranoside, by means of chemical and spectroscopic methods including HRESI-MS, 1D and 2D NMR. In vitro, compound 2 showed cytotoxicity against human lung cancer cell H460 with IC50 value of 66 μg/mL.
authors.affiliation: a Department of Natural Medicinal Chemistry , China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing , 210009 , P.R. China.
authors.forename: Wenna
authors.initials: W
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Jianguang
authors.initials: J
authors.lastname: Luo
authors.forename: Lingyi
authors.initials: L
authors.lastname: Kong
mesh_terms: D006027:Glycosides / Q000737:chemistry*; D032304:Hyoscyamus / Q000737:chemistry*; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry*; D019657:Solanaceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D006027:Glycosides