title: Diosmin--isolation techniques, determination in plant material and pharmaceutical formulations, and clinical use.
abstract: Diosmin is a naturally occurring flavone glycoside used in the treatment of venous diseases. In this review, we present the clinical aspects of the use of diosmin preparations in venous stasis, hemorrheologic disorders and vein wall remodeling. Because of its multiple applications in biology and its many therapeutic activities, research on isolation and identification of diosmin is of high relevance. The aim of this review is to present an overview of techniques of isolation and separation of diosmin in plant material, pharmaceutical formulations such as Daflon, Diosed and Dioven tablets, and biological fluids.
authors.affiliation: Chair and Department of Pharmaceutical Botany, Medical University, Lublin, 20-093 Chodźki 1, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Bogucka-Kocka
authors.forename: Michał
authors.initials: M
authors.lastname: Woźniak
authors.forename: Marcin
authors.initials: M
authors.lastname: Feldo
authors.forename: Janusz
authors.initials: J
authors.lastname: Kockic
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Szewczyk
mesh_terms: D002626:Chemistry, Pharmaceutical; D004145:Diosmin / Q000032:analysis / Q000302:isolation & purification* / Q000627:therapeutic use; D010936:Plant Extracts / Q000032:analysis*
chemical_list: D010936:Plant Extracts; D004145:Diosmin