title: Bioactive dibenzocyclooctadiene lignans from the stems of Schisandra neglecta.
abstract: Seven new unusual dibenzocyclooctadiene lignans, neglignans A-G (1-7), together with 16 known dibenzocyclooctadiene lignans, were isolated from the stems of Schisandra neglecta. Compounds 1 and 2 are the first dibenzocyclooctadiene lignans bearing a carboxyl group at C-4, and compounds 3 and 4 are the first 7,8-seco-dibenzocyclooctadiene lignans found from Nature. The new compounds (1-7) and several of the known compounds were evaluated for their anti-HIV activity and cytotoxicity. Compounds 2 and 6 showed anti-HIV-1 activities with therapeutic index values greater than 50, and compound 4 showed cytotoxicity against the NB4 and SHSY5Y cancer cell lines with IC50 values of 2.9 and 3.3 μM, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Gao
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Wang
authors.forename: De-Yun
authors.initials: DY
authors.lastname: Niu
authors.forename: Chun-Yang
authors.initials: CY
authors.lastname: Meng
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Yang
authors.forename: Qiu-Fen
authors.initials: QF
authors.lastname: Hu
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D034242:Cyclooctanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D034242:Cyclooctanes; D004365:Drugs, Chinese Herbal; D017705:Lignans; C510994:dibenzocyclooctadiene lignan; C583926:neglignan B; C583927:neglignan F