title: Acyclovir-resistant varicella-zoster virus keratitis in an immunocompetent patient.
abstract: Varicella-zoster virus (VZV) resistance to acyclovir (ACV) has only been reported in rare cases of immunocompromised patients. We report the first case of an immunocompetent patient with ACV-resistant VZV keratitis associated with a nucleotide deletion in the VZV thymidine kinase gene, leading to production of a truncated protein.
authors.affiliation: Ophthalmology Department, Charles Nicolle University Hospital, Rouen, France. julie.gueudry@chu-rouen.fr
authors.forename: J
authors.initials: J
authors.lastname: Gueudry
authors.forename: D
authors.initials: D
authors.lastname: Boutolleau
authors.forename: M
authors.initials: M
authors.lastname: Gueudin
authors.forename: S
authors.initials: S
authors.lastname: Burrel
authors.forename: A
authors.initials: A
authors.lastname: Miri
authors.forename: B
authors.initials: B
authors.lastname: Bodaghi
authors.forename: M
authors.initials: M
authors.lastname: Muraine
mesh_terms: D000212:Acyclovir / Q000494:pharmacology / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D024882:Drug Resistance, Viral; D014645:Herpesvirus 3, Human / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D016867:Immunocompromised Host; D016849:Keratitis, Herpetic / Q000188:drug therapy* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D050505:Mutant Proteins / Q000235:genetics; D017384:Sequence Deletion; D013937:Thymidine Kinase / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D050505:Mutant Proteins; D013937:Thymidine Kinase; D000212:Acyclovir
keywords: Acyclovir; Cornea; Drug resistance; Herpetic keratitis; Varicella zoster virus