title: Pulmonary coccidioidomycosis after a renal transplant in a nonendemic region.
abstract: Coccidioidomycosis is a fungal infection caused by the Coccidioides species, endemic to the southwestern United States. In healthy people, manifestations range mainly from asymptomatic to mild influenza-like signs, whereas in immunosuppressed patients (eg, transplant recipients) this infection is often a severe disseminated disease. We report a case of primary pulmonary coccidioidomycosis in a 61-year-old man with a renal transplant 7 months earlier. The patient had nonspecific symptoms of pulmonary infection, including weakness, anorexia, and weight loss. Both spherules and endospores of Coccidioides immitis were seen histologically after a transbronchial biopsy of a cavitary lesion. The patient was treated with amphotericin B. At the time of this writing (8 months), he remains disease free.
authors.affiliation: Department of Pathology, Baskent University, Faculty of Medicine, Ankara.
authors.forename: Merih
authors.initials: M
authors.lastname: Tepeoglu
authors.forename: Hilal
authors.initials: H
authors.lastname: Erinanc
authors.forename: Handan
authors.initials: H
authors.lastname: Ozdemir
authors.forename: Hale
authors.initials: H
authors.lastname: Turan
authors.forename: Gokhan
authors.initials: G
authors.lastname: Moray
authors.forename: Mehmet
authors.initials: M
authors.lastname: Haberal
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D003045:Coccidioides / Q000302:isolation & purification*; D003047:Coccidioidomycosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B