title: [Effect of coronary risk and of hypertension on renal risk in the general population].
abstract: BACKGROUND
  Abnormal albuminuria (≥ 30 mg/g) and low estimated glomerular filtration rate (eGFR<60 mL/min/1.73 m(2)) not only are renal risk factors, but also cardiovascular and coronarian risk factors. Though, the relation between coronary risk and renal risk, and its interaction with insufficiently controlled brachial pressure (BP) is poorly described in the literature.
  
  
  METHODS
  We realised a cross-sectional study on subjects 40 and older, having attended a medical exam in 11 IRSA centers between 2006 and 2010. Every subject filled a questionnaire, underwent biological analysis, and a clinical examination. eGFR and albuminuria were measured, and the 10-year risk of coronarian event was calculated (Laurier's equation)
  
  
  RESULTS
  We analysed 118,314 subjects, amongst whom 96,400 had no personal cardiovascular history. Amongst those, 9.1% had a 10-year coronary risk over 10%. There was a continuous relationship between coronary risk and renal risk: subjects with a risk above 15% had a significative risk of pathological albuminuria (OR: 6.87 [5.58-8.44]), and of low eGFR (2.26 [1.82-2.78]) compared to those with a risk under 5%. There was a continuous relationship between BP and renal risk, with a significative risk of pathological albuminuria (OR=7.75 [6.69-8.96]) and of low eGFR (OR: 1.33 [1.09-1.60]) in subjects with BP greater than or equal to 180/110 mmHg, compared to those with normal BP.
  
  
  CONCLUSIONS
  In the French population, 9.1% of subjects have a 10-year coronary risk above 10%. This risk is associated to abnormalities of the renal function. The relation between coronary risk and renal risk is continuous and dose-dependent, as is the relation between BP and renal risk.
authors.affiliation: Service de néphrologie-immunologie clinique, hôpital Bretonneau, CHU de Tours, 2, boulevard Tonnellé, 37044 Tours cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Bigot
authors.forename: G
authors.initials: G
authors.lastname: Gusto
authors.forename: N
authors.initials: N
authors.lastname: Copin
authors.forename: O
authors.initials: O
authors.lastname: Lantieri
authors.forename: J-M
authors.initials: JM
authors.lastname: Halimi
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D003327:Coronary Disease / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000652:urine; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005602:France; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000652:urine; D007676:Kidney Failure, Chronic / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology / Q000652:urine; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers
keywords: Albuminuria; Albuminurie; Brachial pressure; Coronary risk; DFG bas; Hypertension; Lauriers’ equation; Low GFR; Pression artérielle; Renal risk; Risque coronarien; Risque rénal; Équation de Laurier