title: A microfluidic chip using phenol formaldehyde resin for uniform-sized polycaprolactone and chitosan microparticle generation.
abstract: This study develops a new solvent-compatible microfluidic chip based on phenol formaldehyde resin (PFR). In addition to its solvent-resistant characteristics, this microfluidic platform also features easy fabrication, organization, decomposition for cleaning, and reusability compared with conventional chips. Both solvent-dependent (e.g., polycaprolactone) and nonsolvent-dependent (e.g., chitosan) microparticles were successfully prepared. The size of emulsion droplets could be easily adjusted by tuning the flow rates of the dispersed/continuous phases. After evaporation, polycaprolactone microparticles ranging from 29.3 to 62.7 μm and chitosan microparticles ranging from 215.5 to 566.3 μm were obtained with a 10% relative standard deviation in size. The proposed PFR microfluidic platform has the advantages of active control of the particle size with a narrow size distribution as well as a simple and low cost process with a high throughput.
authors.affiliation: Department of Applied Cosmetology and Master Program of Cosmetic Science, Hungkuang University, Taichung 43302, Taiwan. linys@sunrise.hk.edu.tw
authors.forename: Yung-Sheng
authors.initials: YS
authors.lastname: Lin
authors.forename: Chih-Hui
authors.initials: CH
authors.lastname: Yang
authors.forename: Chin-Tung
authors.initials: CT
authors.lastname: Wu
authors.forename: Alexandru Mihai
authors.initials: AM
authors.lastname: Grumezescu
authors.forename: Chih-Yu
authors.initials: CY
authors.lastname: Wang
authors.forename: Wan-Chen
authors.initials: WC
authors.lastname: Hsieh
authors.forename: Szu-Yu
authors.initials: SY
authors.lastname: Chen
authors.forename: Keng-Shiang
authors.initials: KS
authors.lastname: Huang
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D004655:Emulsions; D005557:Formaldehyde / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques; D044085:Microfluidics / Q000379:methods*; D008863:Microspheres; D010316:Particle Size; D010636:Phenols / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D004655:Emulsions; D010636:Phenols; D011091:Polyesters; D011108:Polymers; D005557:Formaldehyde; C016240:polycaprolactone; C011529:phenol-formaldehyde resin; D048271:Chitosan