title: Bioactive limonoid and triterpenoid constituents of Turraea pubescens.
abstract: Eleven new limonoids, turrapubins A-K (1-11), and three new triterpenoids (12-14), along with 14 known compounds, were isolated from the twigs of Turraea pubescens. The structures of 1-14 were elucidated on the basis of NMR and MS analysis. Compounds 12, 16, 18, and 19 exhibited inhibitory activities against lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. In addition, compounds 2, 11, 18, and 26 exhibited inhibitory activities against brine shrimp larvae (Artemia salina) at 100 ppm with the corrected mortality ranging from 81.7% to 100%.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Chun-Mao
authors.initials: CM
authors.lastname: Yuan
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Tang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Wang
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Cao
authors.forename: Feng
authors.initials: F
authors.lastname: Guo
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Li
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D036701:Limonins; D008070:Lipopolysaccharides; D014315:Triterpenes