title: Design and synthesis of a ruthenium(II) complex-based luminescent probe for highly selective and sensitive luminescence detection of nitric oxide.
abstract: Nitric oxide (NO) is one of the most important intercellular signaling molecules, and plays important roles in various biological systems. In this work, a unique Ru(II) complex, tris[(5-(4-methylamino-3-aminobenzylamino)-1,10-phenanthroline)] ruthenium(II) hexafluorophosphate [Ru(MAA-phen)3][PF6]2, has been designed and synthesized as a luminescent probe for the detection of NO in aqueous media. The complex itself is almost non-luminescent, but can specifically react with NO under the aerobic conditions to afford its highly luminescent triazole derivative in aqueous media, [Ru(MTA-phen)3](2+) (MTA-phen: methyl-trazolebenzylamino-1,10-phenanthroline), accompanied by a 302-fold increase in luminescence intensity at 598 nm with a 130 nm Stokes shift. The luminescence response of [Ru(MAA-phen)3](2+) to NO is rapid, highly specific without interferences of other reactive oxygen/nitrogen species, and highly stable against the pH changes in the range of pH 4.5-9.5. These features enable [Ru(MAA-phen)3](2+) to be used as a probe for the highly selective and sensitive luminescence detection of NO in weakly acidic, neutral, and weakly basic media.
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian, 116024, People's Republic of China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Yu
authors.forename: Run
authors.initials: R
authors.lastname: Zhang
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Ye
authors.forename: Bo
authors.initials: B
authors.lastname: Song
authors.forename: Jingli
authors.initials: J
authors.lastname: Yuan
mesh_terms: D049449:Luminescence; D049408:Luminescent Agents / Q000138:chemical synthesis / Q000737:chemistry*; D009569:Nitric Oxide / Q000032:analysis*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D049408:Luminescent Agents; D009942:Organometallic Compounds; D009569:Nitric Oxide; D012428:Ruthenium