title: Assessing the impact of the NIH CTSA program on institutionally sponsored clinical trials.
abstract: OBJECTIVE
  To assess the impact of the NIH CTSA program on patient enrollment in clinical trials sponsored/collaborated by CTSA consortium institutions.
  
  
  METHODS
  Using publicly available clinical trial data at ClinicalTrials.gov, we identify positive trend changes in the number of patients enrolled in clinical trials performed at CTSA consortium institutions over the years before and after their respective CTSA award dates. CTSA consortium institutions were matched with similar non-CTSA institutions.
  
  
  RESULTS
  As compared to matched non-CTSA institutions CTSA consortium sites noted an increase in patient enrollment after the CTSA awards. In particular, we detected a change-point, where a new enrollment trend emerged, 338 days after the CTSA award. No such trend was noted over the same period in the non-CTSA institutions.
  
  
  CONCLUSIONS
  Our analysis provides evidence that the NIH CTSA funding program made a positive impact on patient enrollment.
authors.affiliation: Penn State College of Medicine, Public Health Sciences, Hershey, PA, USA.
authors.forename: Guodong
authors.initials: G
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Lawrence I
authors.initials: LI
authors.lastname: Sinoway
authors.forename: Arthur
authors.initials: A
authors.lastname: Berg
mesh_terms: D001363:Awards and Prizes; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D003299:Cooperative Behavior; D006801:Humans; D009316:National Institutes of Health (U.S.); D057170:Translational Research, Biomedical / Q000706:statistics & numerical data*; D014481:United States