title: [Thyroid-like follicular carcinoma of the kidney: a separate tumor entity?].
abstract: Thyroid-like follicular carcinoma of the kidney is postulated as a potentially new entity of renal tumor based on nine previously published case reports. This tumor entity is not yet integrated into the classification of tumors of the World Health Organization (WHO). In this article a new case of thyroid-like follicular carcinoma of kidney is described which was incidentally detected at autopsy. The 58-year-old patient died of complications of acute myeloid leukemia after chemotherapy and also had prostatic adenocarcinoma. The renal tumor in the left kidney had a diameter of 3 cm and showed a grey-brown cut surface. Histologically, the tumor presented with a typical thyroid-like microfollicular and macrofollicular structure filled with eosinophilic, colloid-like material with calcification. Immunohistologically the renal tumor was CD 10 positive and negative for thyroid transcription factor 1 (TTF1) and thyroglobulin. A synopsis of the published case reports indicates that thyroid-like follicular carcinoma of the kidney has a low risk of metastasis. More experience with further cases of thyroid-like follicular renal carcinoma is necessary before a recommendation of a separate tumor entity in the next WHO classification is justified.
authors.affiliation: Institut für Klinische Pathologie, UniversitätsSpital Zürich, Zürich, Schweiz, sandra.berens@irm.uzh.ch.
authors.forename: S
authors.initials: S
authors.lastname: Berens
authors.forename: P
authors.initials: P
authors.lastname: Vogt
authors.forename: H
authors.initials: H
authors.lastname: Alkadhi
authors.forename: N
authors.initials: N
authors.lastname: Berger
authors.forename: H
authors.initials: H
authors.lastname: Moch
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D018263:Adenocarcinoma, Follicular / Q000145:classification / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000145:classification / Q000473:pathology*; D006801:Humans; D033162:Incidental Findings; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000145:classification / Q000473:pathology*; D015456:Leukemia, Biphenotypic, Acute / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000145:classification / Q000473:pathology; D015260:Neprilysin / Q000032:analysis; D009687:Nuclear Proteins / Q000032:analysis; D011471:Prostatic Neoplasms / Q000473:pathology; D013954:Thyroglobulin / Q000032:analysis; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D013954:Thyroglobulin; D015260:Neprilysin