title: Epilepsy and neuropsychological comorbidities.
abstract: OBJECTIVE
  Epilepsy is a chronic disorder with several associated comorbidities requiring timely recognition and treatment. This article discusses aspects of cognitive impairment; psychiatric disorders including depression, anxiety, and psychosis; and health-related quality-of-life issues pertaining to patients with epilepsy.
  
  
  RESULTS
  Cognitive problems in epilepsy may be present early in the disease course. Advances in imaging techniques are allowing correlation of structure and function as they relate to cognitive impairment in epilepsy. The relationship between epilepsy, depression, and anxiety is increasingly recognized, and these psychiatric comorbidities may affect suicide risk, patient-reported adverse antiepileptic drug effects, and quality of life. Psychiatric disorders are underrecognized and undertreated in patients with epilepsy.
  
  
  CONCLUSIONS
  Physicians who treat patients with epilepsy should be aware of the major impact that cognitive impairment and psychiatric comorbidities have on these patients. Identifying and treating these comorbidities in epilepsy patients is just as important as seizure treatment.
authors.affiliation: Emory University School of Medicine, 80 Jesse Hill Jr Drive Southeast, Atlanta, Georgia 30300, USA. leslie.a.rudzinski@emory.edu
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Rudzinski
authors.forename: Kimford J
authors.initials: KJ
authors.lastname: Meador
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects; D002648:Child; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology*; D015897:Comorbidity; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology / Q000209:etiology*; D009483:Neuropsychological Tests
chemical_list: D000927:Anticonvulsants