title: Is acetaminophen use associated with atopic eczema and other allergic diseases in adolescents?
abstract: Atopic Eczema (AE) is a chronic inflammatory skin disease that affects children and adults, and alters quality of life. Previous studies have suggested several socio-demographic and environmental factors related to the prevalence of AE and other allergic diseases, including acetaminophen use. In the present study, we report the rates of isolated AE, AE associated with asthma and AE associated with rhinitis among 13- to 14-year-old Spanish adolescents and the level of association of these conditions with the use of acetaminophen. We analyzed Spanish data from a cross-sectional Phase 3 study within ISAAC. A total of 28,717 adolescents completed the Phase 3 written questionnaire by answering questions for acetaminophen use and on asthma, rhinitis and AE symptoms.We observed an association between acetaminophen use and AE among the adolescents who had used acetaminophen in the previous month. Furthermore, the prevalence rate increased with the number of allergic processes: for AE alone, the adjusted Prevalence Ratio (aPR) was 1.81 and for AE associated with rhinitis or with asthma, aPRs were 2.20 and 3.03, respectively.We conclude that acetaminophen use in childhood may be an important factor associated with development and/or maintenance of AE and other allergic diseases.
authors.affiliation: Public and Environmental Health Unit, Department of Preventive Medicine, University of Valencia. CIBER Epidemiology and Public Health (CIBERESP), and Center for Public Health Research (CSISP), Valencia, Spain. maria.m.morales@uv.es.
authors.forename: María Morales
authors.initials: MM
authors.lastname: Suárez-Varela
authors.forename: Luís
authors.initials: L
authors.lastname: García-Marcos
authors.forename: Javier Fuertes
authors.initials: JF
authors.lastname: Fernández-Espinar
authors.forename: Alberto
authors.initials: A
authors.lastname: Bercedo-Sanz
authors.forename: Inés
authors.initials: I
authors.lastname: Aguinaga-Ontoso
authors.forename: Carlos
authors.initials: C
authors.lastname: González-Díaz
authors.forename: Ignacio
authors.initials: I
authors.lastname: Carvajal-Urueña
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Busquet-Monge
authors.forename: Alberto
authors.initials: A
authors.lastname: Arnedo-Pena
authors.forename: Nagore
authors.initials: N
authors.lastname: García de Andoin
authors.forename: José
authors.initials: J
authors.lastname: Batlles-Garrido
authors.forename: Alfredo
authors.initials: A
authors.lastname: Blanco-Quirós
authors.forename: Angel
authors.initials: A
authors.lastname: López-Silvarrey Varela
authors.forename: Gloria
authors.initials: G
authors.lastname: García-Hernández
authors.forename: Natalia
authors.initials: N
authors.lastname: Gimeno-Clemente
authors.forename: Nuria
authors.initials: N
authors.lastname: Rubio-López
authors.forename: Agustín
authors.initials: A
authors.lastname: Llopis-González
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D003876:Dermatitis, Atopic / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D008297:Male; D015995:Prevalence; D011795:Surveys and Questionnaires
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen