title: Spontaneous remission of epstein-barr virus-positive diffuse large B-cell lymphoma of the elderly.
abstract: A 94-year-old female patient presented with anorexia and left axillar lymphadenopathy on admission. Her past history was angina pectoris at 83 years of age and total gastrectomy due to gastric cancer at 87 years. The family history revealed that her son had had a malignant lymphoma, the histopathological diagnosis of which was diffuse large B-cell lymphoma. A physical examination showed both cervical, axillar, and inguinal lymphadenopathy without tenderness. She had elevated lactate dehydrogenase, ferritin, and soluble interleukin-2 receptor (sIL-2R). Whole-body computed tomography confirmed the cervical, axillary, and inguinal lymphadenopathy. Gallium-68 imaging revealed positive accumulation in these superficial lymph nodes. A right inguinal lymph node biopsy showed features of Epstein-Barr virus-associated lymphoproliferative disorder. Immunohistological studies on this lymph node biopsy showed CD20-positive large cells, CD3-positive small cells, and CD30-partly-positive large cells. In situ hybridization showed Epstein-Barr virus-positive, LMP-partly-positive, and EBNA2-negative cells. She refused chemotherapy as her son had died from hematemesis during chemotherapy. She received intravenous hyperalimentation for 1 month after admission. No palpable lymph nodes were identified by physical examination or computed tomography 3 months after admission, and regression of lactate dehydrogenase, ferritin, and sIL-2R was observed. She recovered from anorexia and was discharged. She died from pneumonia 10 months later after initial symptoms of anorexia. The autopsy showed no superficial lymphadenopathy.
authors.affiliation: Departments of Community Medicine, Kanazawa Medical University, Himi Municipal Hospital, Himi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mizuno
authors.forename: M
authors.initials: M
authors.lastname: Ishigaki
authors.forename: K
authors.initials: K
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Matsue
authors.forename: M
authors.initials: M
authors.lastname: Fukushima
authors.forename: H
authors.initials: H
authors.lastname: Minato
authors.forename: N
authors.initials: N
authors.lastname: Nojima
authors.forename: Saito
authors.initials: S
authors.lastname: Atsushi
authors.forename: K
authors.initials: K
authors.lastname: Ishigami
authors.forename: H
authors.initials: H
authors.lastname: Atsumi
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Iguchi
authors.forename: D
authors.initials: D
authors.lastname: Usuda
authors.forename: H
authors.initials: H
authors.lastname: Okamura
authors.forename: S
authors.initials: S
authors.lastname: Urashima
authors.forename: M
authors.initials: M
authors.lastname: Asano
authors.forename: A
authors.initials: A
authors.lastname: Fukuda
authors.forename: Y
authors.initials: Y
authors.lastname: Izumi
authors.forename: N
authors.initials: N
authors.lastname: Takekoshi
authors.forename: T
authors.initials: T
authors.lastname: Kanda
keywords: Elderly; Epstein-Barr virus; Remission; sIL-2R