title: Comparative study of serum zinc, copper, manganese, and iron in preeclamptic pregnant women.
abstract: Preeclampsia complicates 2-8 % of all pregnancies and it is one of the leading causes of maternal mortality and pre-term delivery in the world. Unfortunately, there is scarcity of document discussing the circulating level of several essential trace elements in preeclampsia patients in Bangladesh. The present study was designed to evaluate the serum concentration of four trace elements, namely zinc, copper, manganese, and iron, in preeclamptic pregnant women. The study was conducted as a case-control study with 50 preeclamptic pregnant women as cases and 58 normotensive pregnant women as controls. Obstetric, anthropometric, and clinical data were collected at routine obstetric visits. Serum trace elements were determined by flame atomic absorption spectroscopy. Independent sample t test and Pearson's correlation test were done for the statistical analysis using the statistical software package SPSS, version 16.0 (SPSS Inc., Chicago, IL). We observed significant differences for gestational age, body mass index, and systolic and diastolic blood pressure between patient and control groups (p < 0.05). Analysis of serum trace elements explored significantly lower level of all the four elements in preeclampsia patients in comparison to the control group (p < 0.05). Pearson's correlation analysis explored that the correlation between serum level of different trace elements was statistically insignificant (p > 0.05) except the correlation between zinc and iron in preeclampsia patients (p < 0.05). Establishment of inter-element relationship strongly supports that there was a disturbance in the element homeostasis in patient with preeclampsia. In conclusion, our study suggests that preeclampsia patients have considerably lower level of serum zinc, copper, manganese, and iron compared to the healthy pregnant women.
authors.affiliation: Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh.
authors.forename: Md Shahid
authors.initials: MS
authors.lastname: Sarwar
authors.forename: Salma
authors.initials: S
authors.lastname: Ahmed
authors.forename: Mohd Shahid
authors.initials: MS
authors.lastname: Ullah
authors.forename: Humayun
authors.initials: H
authors.lastname: Kabir
authors.forename: G K M Mustafizur
authors.initials: GK
authors.lastname: Rahman
authors.forename: Abul
authors.initials: A
authors.lastname: Hasnat
authors.forename: Mohammad Safiqul
authors.initials: MS
authors.lastname: Islam
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D016022:Case-Control Studies; D003300:Copper / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007501:Iron / Q000097:blood*; D008345:Manganese / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012015:Reference Standards; D015032:Zinc / Q000097:blood*
chemical_list: D008345:Manganese; D003300:Copper; D007501:Iron; D015032:Zinc