title: Protein C and protein S deficiency presenting as Budd-Chiari syndrome.
abstract: Protein C and S are vitamin K-dependent natural anticoagulants. They play a major role in hemostasis by degrading the activated factor V and factor VIII. Deficiencies of protein C and protein S are associated with increased risk of thrombotic events. The combined occurrence of protein C and S deficiency has been rarely reported. We report a 6-year-old boy with Budd-Chiari syndrome due to combined protein C and protein S deficiency. He was managed with low molecular weight heparin and discharged on long-term warfarin therapy.
authors.affiliation: Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Tamilnadu, India. dr_uvaraj@yahoo.co.in
authors.forename: Periasamy
authors.initials: P
authors.lastname: Uvaraj
authors.forename: Ramar
authors.initials: R
authors.lastname: Rathisharmila
authors.forename: Veerappan
authors.initials: V
authors.lastname: Ilamaran
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D006502:Budd-Chiari Syndrome / Q000097:blood* / Q000188:drug therapy; D002648:Child; D006801:Humans; D008297:Male; D020151:Protein C Deficiency / Q000097:blood* / Q000188:drug therapy; D018455:Protein S Deficiency / Q000097:blood* / Q000188:drug therapy; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014859:Warfarin