title: Legal termination of a pregnancy resulting from transplanted cryopreserved ovarian tissue due to cancer recurrence.
abstract: OBJECTIVE
  To report on a woman who conceived naturally and had a normal intrauterine pregnancy following transplantation of frozen/thawed ovarian tissue but decided to have an early abortion due to recurrence of breast cancer.
  
  
  METHODS
  The patient was diagnosed breast cancer and received antineoplastic treatment that forced her into premature ovarian insufficiency and infertility. Ovarian tissue cryopreserved prior to chemotherapy was transplanted following cancer treatment restoring fertility and regular menstrual cycles.
  
  
  RESULTS
  The patient conceived 6 month after transplantation. However, she experienced recurrence of breast cancer and decided on legal termination of the pregnancy in the first trimester.
  
  
  CONCLUSIONS
  The obtained pregnancy only 6 month following transplantation underlines the ability of the procedure. The recurrence occurred near the original site of the tumor and was most unlikely related to the transplantation. The activity of the transplanted tissue is likely to be destroyed by the renewed antineoplastic treatment she will receive. However, she still has the majority of one ovary cryostored and may later want to undergo additional transplantation to regain fertility or to have menstrual cycles back.
authors.affiliation: Institute for Biomedicine - Section West, Aarhus University, Ole Worms Allé 2, build. 1170, 8000, Aarhus C, Denmark. ehernst@biokemi.au.dk
authors.forename: Emil Hagen
authors.initials: EH
authors.lastname: Ernst
authors.forename: Birgitte Vrou
authors.initials: BV
authors.lastname: Offersen
authors.forename: Claus Yding
authors.initials: CY
authors.lastname: Andersen
authors.forename: Erik
authors.initials: E
authors.lastname: Ernst
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology*; D015925:Cryopreservation; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D009364:Neoplasm Recurrence, Local; D010053:Ovary / Q000637:transplantation*; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced; D014182:Transplantation, Autologous
chemical_list: D000970:Antineoplastic Agents