title: Oxidative system in aged skeletal muscle.
abstract: Aging is an inevitable biological process that is characterized by a general decline in the physiological and biochemical functions of the major systems. In the case of the neuromuscular system, reductions in strength and mobility cause a deterioration in motor performance, impaired mobility and disability. At the cellular level, aging is caused by a progressive decline in mitochondrial function that results in the accumulation of reactive oxygen species (ROS). As the level of oxidative stress in skeletal muscle increases with age, the age-process is characterized by an imbalance between an increase in ROS production in the organism, and antioxidant defences as a whole. We have reviewed the literature on oxidative stress in aging human skeletal muscles, and to assesss the impact of differences in physiological factors (sex, fiber composition, muscle type and function).
authors.affiliation: Laboratory of Pharmaco-biochemistry, Nutrition and Nutraceutics of Wellness, University of Pavia, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Buonocore
authors.forename: Sara
authors.initials: S
authors.lastname: Rucci
authors.forename: Matteo
authors.initials: M
authors.lastname: Vandoni
authors.forename: Massimo
authors.initials: M
authors.lastname: Negro
authors.forename: Fulvio
authors.initials: F
authors.lastname: Marzatico
keywords: ROS; aged skeletal muscle; markers of skeletal muscle aging; oxidative system; sarcopenia