title: Otostegia persica extraction on healing process of burn wounds.
abstract: OBJECTIVE
  To investigate if the methanolic extract of the Otostegia persica can accelerating healing process of burn wound because of its anti-inflammatory and antioxidant effects.
  
  
  METHODS
  Forty eight male Wistar rats were randomized into three study groups of 16 rats each. Burn wounds were created on dorsal part of shaved rats using a metal rod. In group I the burn wound was left without any treatment. Group was treated with topical silver sulfadiazine pomade. In group III, ointment containing the OP extract was administered. Skin biopsies were harvested from burn area on the 3rd, 5th, 14th and 21st days after burn and examined histologically.
  
  
  RESULTS
  Re-epithelialization in the control group and in group II was lower than in group III. Re-epithelialization in groups II and III was significantly different from that in the control group. On the 5th day of the experiment, we assessed lower inflammation in the burn area compared to control group. This means that the inflammation was suppressed by methanolic extract of OP. From day 5 to 14; the fibroblast proliferation peaked and was associated with increased collagen accumulation. It was obvious that angiogenesis improved more in the groups II and III, which facilitated re-epithelialisation.
  
  
  CONCLUSIONS
  Methanolic extract of Otostegia persica exhibited significant healing activity when topically applied on rats. OP is an effective treatment for saving the burn site.
authors.affiliation: Faculty of Experimental Science, Kahnooj Branch, Islamic Azad University, Kerman, Iran. amin.ganjali@yahoo.com
authors.forename: Amin
authors.initials: A
authors.lastname: Ganjali
authors.forename: Amir
authors.initials: A
authors.lastname: Sotoudeh
authors.forename: Amirali
authors.initials: A
authors.lastname: Jahanshahi
authors.forename: Mohammad Ashrafzadeh
authors.initials: MA
authors.lastname: Takhtfooladi
authors.forename: Ali
authors.initials: A
authors.lastname: Bazzazan
authors.forename: Nasim
authors.initials: N
authors.lastname: Roodbari
authors.forename: Maryam Pourramezani
authors.initials: MP
authors.lastname: Harati
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D001706:Biopsy; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D019686:Lamiaceae / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010936:Plant Extracts