title: [Tetrapeptide stimulates functional activity of the pancreatic cells in aging].
abstract: In this study the molecular mechanisms of pancreoprotective action of researched tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging pancreatic cells of a human were investigated. It is established that the studied tetrapeptide increases the expression of matrix metalloproteinase MMP2, MMP9, serotonin, glycoprotein CD79alpha, antiapoptotic protein Mcl1, proliferation markers PCNA and Ki67 and decreases the expression of proapoptotic protein p53 in aged pancreatic cell cultures. Thus, the capability to activate the expression of signaling molecules--markers of functional activity of pancreatic cells lies behind the clinical effect of studied tetrapeptide observing in elderly patients with type 2 diabetes mellitus.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: N N
authors.initials: NN
authors.lastname: Sevost'ianova
authors.forename: A O
authors.initials: AO
authors.lastname: Durnova
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
authors.forename: S I
authors.initials: SI
authors.lastname: Tarnovskaia
authors.forename: A V
authors.initials: AV
authors.lastname: Dudkov
authors.forename: T V
authors.initials: TV
authors.lastname: Kvetnaia
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D018929:Cell Culture Techniques; D002460:Cell Line; D016922:Cellular Senescence / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009842:Oligopeptides / Q000494:pharmacology*; D010179:Pancreas / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
chemical_list: D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009842:Oligopeptides; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; C531938:lysyl-glutamyl-aspartyl-tryptophanamide