title: RNA editing and drug discovery for cancer therapy.
abstract: RNA editing is vital to provide the RNA and protein complexity to regulate the gene expression. Correct RNA editing maintains the cell function and organism development. Imbalance of the RNA editing machinery may lead to diseases and cancers. Recently, RNA editing has been recognized as a target for drug discovery although few studies targeting RNA editing for disease and cancer therapy were reported in the field of natural products. Therefore, RNA editing may be a potential target for therapeutic natural products. In this review, we provide a literature overview of the biological functions of RNA editing on gene expression, diseases, cancers, and drugs. The bioinformatics resources of RNA editing were also summarized.
authors.affiliation: Department of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Wei-Hsuan
authors.initials: WH
authors.lastname: Huang
authors.forename: Chao-Neng
authors.initials: CN
authors.lastname: Tseng
authors.forename: Jen-Yang
authors.initials: JY
authors.lastname: Tang
authors.forename: Cheng-Hong
authors.initials: CH
authors.lastname: Yang
authors.forename: Shih-Shin
authors.initials: SS
authors.lastname: Liang
authors.forename: Hsueh-Wei
authors.initials: HW
authors.lastname: Chang
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects / Q000235:genetics*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000235:genetics*; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D017393:RNA Editing / Q000235:genetics*
chemical_list: D009363:Neoplasm Proteins