title: The oxidative and antioxidative status of simple febrile seizure patients.
abstract: OBJECTIVE
  To evaluate the oxidative status following a seizure in children experiencing a simple febrile seizure.
  
  
  METHODS
  The cross-sectional study was conducted at Harran University, Turkey, between January and September 2011. It comprised 32 paediatric patients who, within the preceding 8 hours, had experienced a seizure due to upper respiratory tract infection and had been diagnosed with simple febrile seizure, and 30 healthy children as the control group. Blood was taken from the patients 8 hours after the seizure. Total oxidant level and Total anti-oxidant level were measured according to the Erel technique and the oxidative stress index was calculated. Data was analysed using SPSS 11.5.
  
  
  RESULTS
  The mean values of the total oxidant level and the oxidative stress index of the cases were found to be significantly high compared to the controls and the total anti-oxidant level was found to be significantly low (p < 0.01, p < 0.01, p < 0.03 respectively).
  
  
  CONCLUSIONS
  The increased total oxidant level and decreased total anti-oxidant level resulting in increased oxidative stress associated with febrile seizure patients may increase the risk of experiencing febrile seizures.
authors.affiliation: Department of Paediatrics, Medical Faculty, Harran University, Sanliurfa, Turkey. drabuhandan@mynet.com
authors.forename: Mahmut
authors.initials: M
authors.lastname: Abuhandan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Calik
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taskin
authors.forename: Ilhan
authors.initials: I
authors.lastname: Yetkin
authors.forename: Sahabettin
authors.initials: S
authors.lastname: Selek
authors.forename: Akin
authors.initials: A
authors.lastname: Iscan
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010031:Otitis / Q000150:complications; D016877:Oxidants / Q000097:blood*; D003294:Seizures, Febrile / Q000097:blood* / Q000209:etiology; D014069:Tonsillitis / Q000150:complications
chemical_list: D000975:Antioxidants; D016877:Oxidants