title: Structure and allosteric regulation of eukaryotic 6-phosphofructokinases.
abstract: Although the crystal structures of prokaryotic 6-phosphofructokinase, a key enzyme of glycolysis, have been available for almost 25 years now, structural information about the more complex and highly regulated eukaryotic enzymes is still lacking until now. This review provides an overview of the current knowledge of eukaryotic 6-phosphofructokinase based on recent crystal structures, kinetic analyses and site-directed mutagenesis data with special focus on the molecular architecture and the structural basis of allosteric regulation.
authors.affiliation: Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, D-04103 Leipzig, Germany.
authors.forename: Torsten
authors.initials: T
authors.lastname: Schöneberg
authors.forename: Marco
authors.initials: M
authors.lastname: Kloos
authors.forename: Antje
authors.initials: A
authors.lastname: Brüser
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kirchberger
authors.forename: Norbert
authors.initials: N
authors.lastname: Sträter
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D006014:Glycogen Storage Disease Type VII / Q000235:genetics / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D008958:Models, Molecular; D009154:Mutation; D010732:Phosphofructokinase-1 / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation
chemical_list: D010732:Phosphofructokinase-1