title: Equine developmental orthopaedic diseases--a genome-wide association study of first phalanx plantar osteochondral fragments in Standardbred trotters.
abstract: Palmar/plantar osteochondral fragments (POF) in fetlock joints commonly affect and influence the athletic performance of horses. In this study, we used the Equine SNP50 BeadChip® to perform a genome-wide association study of metatarsophalangeal POF in 176 Norwegian Standardbred trotter yearlings. Putative quantitative trait loci (QTL) for medial and/or lateral POF, and medial POF only were identified on ECA1, 2, 7, 9 and 31, whereas for lateral POF, only on ECA7, 11, 27 and X. The moderate number of QTL evidences a complex inheritance and suggests various genes controlling POF development in medial and lateral locations.
authors.affiliation: Department of Basic Sciences and Aquatic Medicine, The Norwegian School of Veterinary Science, Post-box 8146 Dep., N-0033, Oslo, Norway; Department of Companion Animal Clinical Sciences, Section for Equine Medicine and Surgery, The Norwegian School of Veterinary Science, Post-box 8146 Dep, N-0033, Oslo, Norway.
authors.forename: S
authors.initials: S
authors.lastname: Lykkjen
authors.forename: N I
authors.initials: NI
authors.lastname: Dolvik
authors.forename: M E
authors.initials: ME
authors.lastname: McCue
authors.forename: A K
authors.initials: AK
authors.lastname: Rendahl
authors.forename: J R
authors.initials: JR
authors.lastname: Mickelson
authors.forename: K H
authors.initials: KH
authors.lastname: Røed
mesh_terms: D000818:Animals; D055106:Genome-Wide Association Study / Q000662:veterinary; D006734:Horse Diseases / Q000000981:diagnostic imaging* / Q000235:genetics*; D006736:Horses; D007592:Joint Diseases / Q000000981:diagnostic imaging / Q000235:genetics / Q000662:veterinary*; D016015:Logistic Models; D009664:Norway; D020411:Oligonucleotide Array Sequence Analysis / Q000662:veterinary; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011859:Radiography
keywords: Equine SNP50 BeadChip®; horse; osteochondrosis; palmar/plantar osteochondral fragments; quantitative trait loci