title: Two-year results of an open-label randomized comparison of everolimus-eluting stents and sirolimus-eluting stents.
abstract: BACKGROUND
  Second generation drug-eluting stents were developed to improve the safety and efficacy of first generation stents. So far, limited long term randomized data exist comparing the second generation everolimus-eluting stents (EES) with first generation sirolimus-eluting stents (SES).
  
  
  METHODS
  A prospective, open-label, randomized, single center trial comparing EES and SES in all-comer patients. The primary endpoint was a composite of cardiac mortality, myocardial infarction and target vessel revascularization. Secondary endpoints included individual components of the composite, along with target lesion revascularization and stent thrombosis.
  
  
  RESULTS
  In total, 977 patients were randomized, of which 498 patients to EES and 479 to SES. Average age was 65.2 ± 11.2 years and 71.6% of the population was male. Fifty percent of patients were treated for acute coronary syndrome, more often for ST-elevation myocardial infarctions in EES patients (13.7% vs. 9.2% in SES). In contrast, SES patients more often had prior interventions and showed more calcified lesions. Two-year follow-up was available in 98% of patients. The primary endpoint occurred in 10.7% of EES patients compared to 10.6% of SES patients (HR 1.00, 95% CI 0.68-1.48). Additionally, secondary endpoints were similar between groups. The rate of stent thrombosis was low for both stent types.
  
  
  CONCLUSIONS
  In this all-comer population, there were no differences in endpoints between EES and SES during two-year follow-up. Stent thrombosis rates were low, supporting the safety of drug-eluting stent appliance in clinical practice.
  
  
  BACKGROUND
  TrialRegister.nl NTR3170.
authors.affiliation: Medical Center Leeuwarden, Leeuwarden, The Netherlands. m.a.velders@lumc.nl
authors.forename: Matthijs A
authors.initials: MA
authors.lastname: Velders
authors.forename: Sjoerd H
authors.initials: SH
authors.lastname: Hofma
authors.forename: Jan
authors.initials: J
authors.lastname: Brouwer
authors.forename: Cornelis Jan
authors.initials: CJ
authors.lastname: de Vries
authors.forename: Cees Jan
authors.initials: CJ
authors.lastname: de Vries
authors.forename: Michel
authors.initials: M
authors.lastname: Queré
authors.forename: Adrianus J
authors.initials: AJ
authors.lastname: van Boven
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D054855:Drug-Eluting Stents; D000068338:Everolimus; D005260:Female; D006801:Humans; D008297:Male; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000068338:Everolimus; D020123:Sirolimus