title: Unraveling tumor suppressor networks with in vivo RNAi.
abstract: BMI1 is a known oncogenic transcriptional repressor in glioblastoma stem-like cells, but its downstream mediators are poorly understood. Recently, in Cancer Cell, Gargiulo et al. (2013) designed a rational in vivo RNAi screen based on BMI1 ChIP-seq from neural progenitors and identified functional tumor suppressor targets, including Atf3 and Cbx7.
authors.affiliation: Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Braun
authors.forename: Michael T
authors.initials: MT
authors.lastname: Hemann
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D059865:Endoplasmic Reticulum Stress; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D063150:Polycomb Repressive Complex 1 / Q000235:genetics* / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D019485:Bone Morphogenetic Proteins; D011518:Proto-Oncogene Proteins; D016212:Transforming Growth Factor beta; D063150:Polycomb Repressive Complex 1