title: [Developments in meniscus tissue engineering research].
abstract: OBJECTIVE
  To review the current development in meniscus tissue engineering.
  
  
  METHODS
  Recent literature concerning the development of the meniscus tissue engineering was extensively reviewed and summarized.
  
  
  RESULTS
  Recent researches mainly focus on: selection of seed cells and research of their potential of differentiation into chondrocytes; selection of scaffold materials and research of their mechanical properties; cytokines and their mechanisms of action.
  
  
  CONCLUSIONS
  Many achievements have been made in meniscus tissue engineering. Most important topics in future research include: finding seed cells that are adapted to physiological process, are easy to culture, and have higher chondrogenic differentiation ability; looking for necessary cytokines and their mechanisms of action; finding scaffold meterials with strong morphological plasticity, no antigenicity, good degradability, and mechanical property close to normal meniscus.
authors.affiliation: Department of Joint Surgery, Shanghai Changzheng Hospital, Shanghai, 200003, P.R.China.
authors.forename: Peiliang
authors.initials: P
authors.lastname: Fu
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Haishan
authors.initials: H
authors.lastname: Wu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001696:Biomechanical Phenomena; D001854:Bone Marrow Cells / Q000166:cytology; D018929:Cell Culture Techniques / Q000379:methods*; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology; D003470:Culture Media / Q000737:chemistry; D016207:Cytokines / Q000737:chemistry / Q000494:pharmacology; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008592:Menisci, Tibial / Q000166:cytology* / Q000601:surgery; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D000070600:Tibial Meniscus Injuries; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D003470:Culture Media; D016207:Cytokines