title: Fomentarols A-D, sterols from the polypore macrofungus Fomes fomentarius.
abstract: Four (1-4) hitherto unknown and seven (5-11) known ergostane-type sterols were isolated from the EtOH extract of the dried fruiting bodies of the polypore macrofungus Fomes fomentarius. On the basis of spectroscopic analysis, the structures of polyhydroxylated sterols 1-4 were elucidated to be (22E,24R)-3β,5α,6β,14α-tetrahydroxyergosta-7,9(11),22-triene (fomentarol A, 1), (22E,24R)-3β,5β,6α,7α-tetrahydroxy-8α,9α-dihydroergosta-14,22-diene (fomentarol B, 2), (22E,24R)-3β,5α-dihydroxy-6β-ethoxyergosta-7,22-diene (fomentarol C, 3), and (22E,24S)-3β,25-dihydroxy-15α-O-β-D-glucopyranosylergosta-7,22-dien-6-one (fomentarol D, 4), respectively. Rings A/B and B/C are in turn cis-fused in compound 2, which is uncommon in natural ergostane-type sterols. The potential biogenetic relationship of 2 and other ergostane-type sterols isolated from F. fomentarius was briefly discussed. Moderate cytotoxic effects of the isolated sterols against a small panel of human cancer cell lines were also established.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zang
authors.forename: Juan
authors.initials: J
authors.lastname: Xiong
authors.forename: Wen-Zhu
authors.initials: WZ
authors.lastname: Zhai
authors.forename: Lei
authors.initials: L
authors.lastname: Cao
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Tang
authors.forename: Ji
authors.initials: J
authors.lastname: Wang
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Su
authors.forename: Guo-Xun
authors.initials: GX
authors.lastname: Yang
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Hui
authors.initials: H
authors.lastname: Fan
authors.forename: Gang
authors.initials: G
authors.lastname: Xia
authors.forename: Chuan-Gui
authors.initials: CG
authors.lastname: Wang
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Hu
mesh_terms: D055453:Coriolaceae / Q000737:chemistry*; D008968:Molecular Conformation; D013237:Stereoisomerism; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D013261:Sterols; C585779:fomentarol A; C585777:fomentarol B; C585778:fomentarol C