title: Association study between MAO-A gene promoter VNTR polymorphisms and obsessive-compulsive disorder.
abstract: A functional variant in the mono-amine oxidase-A (MAO-A) gene has been shown to affect neural function related to several mental disorders. Therefore, we would like to ascertain if MAO-A could be a candidate gene for obsessive-compulsive disorder (OCD). We genotyped 414 healthy subjects and 240 OCD patients and found no significant difference not only in allele frequencies in male patients (χ(2) = 0.365, DF = 1, P = 0.545, odds ratio (OR) = 1.139, confidence interval (CI) = 0.75-1.74) but also in allele frequencies (χ(2) = 0.698, DF = 1, P = 0.404, OR = 0.849, CI = 0.579-1.246) or genotypic frequencies (χ(2)=0.933, DF = 2, P = 0.627) in female patients between OCD patients and controls. Given that this is the first investigation of this gene in OCD in a Chinese Han population, further studies are required to obtain more definitive conclusions in a larger number of subjects.
authors.affiliation: Shandong Provincial Key Laboratory of Metabolic Disease, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China. qdmc_genetics@163.com
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.forename: Yingying
authors.initials: Y
authors.lastname: Yin
authors.forename: Zusen
authors.initials: Z
authors.lastname: Wang
authors.forename: Xinhua
authors.initials: X
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics*; D008995:Monoamine Oxidase / Q000235:genetics*; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
chemical_list: D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human