title: Prevalence of human parvovirus B19, bocavirus, and PARV4 in blood samples from the general population of China and lack of a correlation between parvovirus and hepatitis B co-infection.
abstract: Few comprehensive studies have investigated viraemia caused by human parvoviruses (HPAVs) in China. A total of 1626 of blood samples were collected from non-HBV and HBV infected Chinese subjects (adults, N = 1279; children, N = 347) from south-western and south-eastern China. DNA from three HPAVs was detected in blood samples using PCR-based assays. The epidemiological profiles and association with HBV co-infection were also analysed. Of the 1626 blood samples tested, 138 (8.49%) were found to exhibit HPAV viraemia, including 3.51% with B19, 3.75% with HBoV and 2.52% with PARV4. The presence of B19 DNA in both child and adult, as well as that of PARV4 DNA in adult,from the south-western region was significantly higher than that from the south-eastern region (P = 0.006 for B19 in children; P = 0.026 for B19 in adults; and P = 0.014 for PARV4 in adult).However, the frequency of HBoV DNA in adults from the south-western region was significantly lower than that observed in adults from the south-eastern region (P = 0.001). Furthermore, HBoV was more prevalence in male (4.9%) than in female (1.4%) individuals. In addition, no significant correlation between HBV and HPAV co-infection was found using serum samples from Chinese adults. In conclusions,the molecular prevalence of three HPAVs in blood samples exhibited variation among different populations depending on area, age and gender; No association between HPAV and HBV infection in adults was found. Our data provide a basis for improving blood safety and preventing HPAV infection in China.
authors.affiliation: Institute of Medical Virology, Wenzhou Medical College, Zhejiang, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Tong
authors.forename: Liping
authors.initials: L
authors.lastname: Shen
authors.forename: Wenjiao
authors.initials: W
authors.lastname: Yin
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhou
authors.forename: Jian
authors.initials: J
authors.lastname: Lu
authors.forename: Meiqin
authors.initials: M
authors.lastname: Zheng
authors.forename: Shengli
authors.initials: S
authors.lastname: Bi
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Lou
authors.forename: Wenjie
authors.initials: W
authors.lastname: Tan
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D058070:Asymptomatic Diseases; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D060085:Coinfection / Q000097:blood* / Q000453:epidemiology / Q000821:virology*; D005260:Female; D006509:Hepatitis B / Q000097:blood* / Q000453:epidemiology / Q000821:virology*; D056661:Human bocavirus / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000097:blood* / Q000453:epidemiology; D016732:Parvovirus B19, Human / Q000302:isolation & purification* / Q000502:physiology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D017678:Sex Distribution; D055815:Young Adult