title: Association of HLA-G 3' untranslated region polymorphisms with antibody response against Plasmodium falciparum antigens: preliminary results.
abstract: Host and Plasmodium interactions result in highly variable clinical phenotypes, partly explained by the nature and level of anti-malarial antibody response. Human leukocyte antigen (HLA)-G can create a tolerogenic environment, allowing parasites to escape from anti-malarial immunity. We performed a family-based association study encompassing 483 Sereer individuals (261 children and their parents), and reported two independent signals at the HLA-G 3' untranslated region associated with antibody response to specific Plasmodium falciparum blood stage antigens, previously associated with malaria protection: (i) +3010G together with +3142C with total IgG and IgG1 against GLURP and (ii) +3196G with IgG3 against MSP2. While these results require further investigation, they suggest for the first time a role of HLA-G in the regulation of humoral immune response in malaria.
authors.affiliation: Institut de Recherche pour le Développement, UMR 216 Mère et enfant face aux infections tropicales, Paris, France. audrey.sabbagh@ird.fr
authors.forename: A
authors.initials: A
authors.lastname: Sabbagh
authors.forename: D
authors.initials: D
authors.lastname: Courtin
authors.forename: J
authors.initials: J
authors.lastname: Milet
authors.forename: J D
authors.initials: JD
authors.lastname: Massaro
authors.forename: E C
authors.initials: EC
authors.lastname: Castelli
authors.forename: F
authors.initials: F
authors.lastname: Migot-Nabias
authors.forename: B
authors.initials: B
authors.lastname: Favier
authors.forename: N
authors.initials: N
authors.lastname: Rouas-Freiss
authors.forename: P
authors.initials: P
authors.lastname: Moreau
authors.forename: A
authors.initials: A
authors.lastname: Garcia
authors.forename: E A
authors.initials: EA
authors.lastname: Donadi
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D000293:Adolescent; D000917:Antibody Formation / Q000276:immunology*; D000953:Antigens, Protozoan / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D056726:Genetic Association Studies; D059951:HLA-G Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D016778:Malaria, Falciparum / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology*; D011110:Polymorphism, Genetic; D012675:Senegal
chemical_list: D020413:3' Untranslated Regions; D000953:Antigens, Protozoan; D059951:HLA-G Antigens