title: Chicken interferons, their receptors and interferon-stimulated genes.
abstract: The prevalence of pathogenic viruses is a serious issue as they pose a constant threat to both the poultry industry and to human health. To prevent these viral infections an understanding of the host-virus response is critical, especially for the development of novel therapeutics. One approach in the control of viral infections would be to boost the immune response through administration of cytokines, such as interferons. However, the innate immune response in chickens is poorly characterised, particularly concerning the interferon pathway. This review will provide an overview of our current understanding of the interferon system of chickens, including their cognate receptors and known interferon-stimulated gene products.
authors.affiliation: CSIRO Biosecurity Flagship, Australian Animal Health Laboratories, Geelong, VIC, Australia.
authors.forename: Kate E
authors.initials: KE
authors.lastname: Goossens
authors.forename: Alister C
authors.initials: AC
authors.lastname: Ward
authors.forename: John W
authors.initials: JW
authors.lastname: Lowenthal
authors.forename: Andrew G D
authors.initials: AG
authors.lastname: Bean
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D002645:Chickens / Q000276:immunology* / Q000382:microbiology / Q000821:virology; D005786:Gene Expression Regulation; D007113:Immunity, Innate; D007372:Interferons / Q000235:genetics / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000235:genetics / Q000276:immunology* / Q000821:virology; D017471:Receptors, Interferon / Q000235:genetics / Q000276:immunology*; D050791:STAT Transcription Factors / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction; D019892:eIF-2 Kinase / Q000235:genetics / Q000276:immunology
chemical_list: D017471:Receptors, Interferon; D050791:STAT Transcription Factors; D007372:Interferons; D019892:eIF-2 Kinase
keywords: Anti-viral therapeutics; Chicken; Interferon; Interferon-stimulated genes