title: A supramolecular DNA self-assembly based on β-cyclodextrin-adamantane complexation as a bioorthogonal sticky end motif.
abstract: We propose linear end-to-end assemblies of short DNA duplexes based on β-cyclodextrin-adamantane complexation. The assembled duplexes exhibited increased Tm values compared with those of the corresponding natural hybrids. Competition experiments with external guest molecules showed a substantial decrease in Tm of the terminal modified duplexes, suggesting the viability of inter-duplex complexation.
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930-0194, Japan. chiba@pha.u-toyama.ac.jp
authors.forename: Junya
authors.initials: J
authors.lastname: Chiba
authors.forename: Ayumi
authors.initials: A
authors.lastname: Sakai
authors.forename: Syogo
authors.initials: S
authors.lastname: Yamada
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Masahiko
authors.initials: M
authors.lastname: Inouye
mesh_terms: D000218:Adamantane / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D009838:Oligodeoxyribonucleotides; D047392:beta-Cyclodextrins; D004247:DNA; C031215:betadex; D000218:Adamantane