title: Successful treatment of diffuse normolipemic plane xanthoma with probucol.
abstract: We report on a 70-year-old woman with diffuse normolipemic plane xanthoma (DNPX) who developed macular yellowish patches on the eyelids, both cheeks, and the nose. Histology revealed the accumulation of CD68-positive foam cells and Touton giant cells in the superficial dermis. Plasma lipid levels were within normal limits. The patient had no underlying hematological diseases. Her extensive lesions precluded surgical excision. The patient was given oral probucol instead, which resulted in a significant reduction of the lesions after 2 weeks. The lesions almost disappeared within 8 months. Plane xanthoma is primarily treated with excisional or abrasive therapies; however, probucol can be a safe and effective alternative therapy for DNPX.
authors.affiliation: Department of Dermatology, Nara Medical University, Kashihara, Japan.
authors.forename: Fumi
authors.initials: F
authors.lastname: Miyagawa
authors.forename: Takaya
authors.initials: T
authors.lastname: Fukumoto
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Asada
keywords: Normolipemic; Plane xanthoma; Probucol