title: [Expression and significance of pulmonary surfactant protein D and IL-16 in allergic rhinitis and nasal polyps].
abstract: OBJECTIVE
  To detect the expression and distribution of the lung surfactant protein D (surfactant protein D,SP-D ) and IL-16 in nasal mucosa of allergic rhinitis and nasal polyps, and then probe into their significance in the pathology of allergic rhinitis and nasal polyps.
  
  
  METHODS
  Fifteen cases of allergic rhinitis, fifteen cases of nasal polyps and fifteen cases of inferior turbinate mucosa were studied to detect the expression of SP-D and IL-16 by immunohistochemistry method.
  
  
  RESULTS
  The expression of SP-D and IL-16 in allergic rhinitis and nasal polyps were dramatically higher in controls (P < 0.01). There was no remarkable difference in the expression of SP-D and IL-16 between allergic rhinitis and nasal polyps (P > 0.05).
  
  
  CONCLUSIONS
  Both normal tissue and diseased tissue express SP-D and IL-16. SP-D is likely to play key roles in the inflammatory reaction process of allergic rhinitis and nasal polyps. IL-16 is an important eosinophil chemokine in the process of allergic rhinitis and nasal polyps,and it can also enhance the local role of eosinophils,thus it can involve in the process of allergic rhinitis and nasal polyps disease.
authors.affiliation: Department of Otolaryngology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou,450014, China.
authors.forename: Linghao
authors.initials: L
authors.lastname: Meng
authors.forename: Manying
authors.initials: M
authors.lastname: Geng
authors.forename: Baoxing
authors.initials: B
authors.lastname: Yan
authors.forename: Xing
authors.initials: X
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D019410:Interleukin-16 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology; D037663:Pulmonary Surfactant-Associated Protein D / Q000378:metabolism*; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D019410:Interleukin-16; D037663:Pulmonary Surfactant-Associated Protein D