title: Thermoresponsive organic-inorganic hybrid large-compound vesicles.
abstract: Herein, gelated thermoresponsive large-compound vesicles (LCVs) are reported for the first time. The LCVs are prepared by self-assembly of poly(ethylene oxide)-block-poly[N-isopropylacrylamide-random-3-(trimethoxysilyl)propyl methacrylate] [PEO-b-P(NIPAM-r-TMPM)] in DMF-water mixture. Then, sol-gel reaction of the reactive PTMPM block is performed to stabilize the LCVs. LCVs with higher cross-linking density keep almost the same size under different temperatures while LCVs with lower cross-linking density display obviously thermoresponsive size transition between 22 and 36 °C. The gelated LCVs exhibit enhanced permeability with temperature elevation and their permeabilities at different temperatures all elevate with increasing the cross-linking density.
authors.affiliation: Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Peng
authors.forename: Yongming
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000962:Antimalarials / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004126:Dimethylformamide / Q000737:chemistry; D004339:Drug Compounding; D005782:Gels; D006886:Hydroxychloroquine / Q000737:chemistry; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D010539:Permeability; D044367:Phase Transition; D011092:Polyethylene Glycols / Q000737:chemistry*; D058105:Polymerization; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D000962:Antimalarials; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D005782:Gels; D008689:Methacrylates; D014867:Water; D011092:Polyethylene Glycols; D006886:Hydroxychloroquine; D004126:Dimethylformamide
keywords: block co-polymers; cross-linking; self-assembly; vesicles