title: Phenotypic and genotypic characterization of acyclovir-resistant corneal HSV-1 isolates from immunocompetent patients with recurrent herpetic keratitis.
abstract: Herpes simplex virus type 1 (HSV-1) is a leading cause of corneal blindness. Acyclovir (ACV) constitutes the standard treatment of HSV infections including herpetic keratitis (HK). HSV resistance to ACV is mainly described in immunocompromised patients. We describe two cases of ACV-resistant corneal HSV-1 in immunocompetent individuals with recurrent HK.
authors.affiliation: UPMC Univ Paris 06, ER1 DETIV, F-75013 Paris, France.
authors.forename: Sonia
authors.initials: S
authors.lastname: Burrel
authors.forename: David
authors.initials: D
authors.lastname: Boutolleau
authors.forename: Georges
authors.initials: G
authors.lastname: Azar
authors.forename: Serge
authors.initials: S
authors.lastname: Doan
authors.forename: Claire
authors.initials: C
authors.lastname: Deback
authors.forename: Isabelle
authors.initials: I
authors.lastname: Cochereau
authors.forename: Henri
authors.initials: H
authors.lastname: Agut
authors.forename: Eric E
authors.initials: EE
authors.lastname: Gabison
mesh_terms: D000212:Acyclovir / Q000494:pharmacology / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004259:DNA-Directed DNA Polymerase / Q000235:genetics; D024882:Drug Resistance, Viral; D005090:Exodeoxyribonucleases / Q000235:genetics; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D016849:Keratitis, Herpetic / Q000188:drug therapy* / Q000821:virology*; D008297:Male; D008826:Microbial Sensitivity Tests; D050505:Mutant Proteins / Q000235:genetics; D020125:Mutation, Missense; D012008:Recurrence; D013937:Thymidine Kinase / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D050505:Mutant Proteins; D014764:Viral Proteins; D013937:Thymidine Kinase; D004259:DNA-Directed DNA Polymerase; D005090:Exodeoxyribonucleases; C043417:DNA polymerase, Simplexvirus; D000212:Acyclovir
keywords: Herpetic keratitis; Immunocompetent patient; Phenotypic and genotypic antiviral resistance assay; Resistance to acyclovir