title: Feasibility of dasatinib in children and adolescents with new or recurrent central nervous system germinoma.
abstract: Germinomas and embryonal carcinomas are central nervous system (CNS) germ cell tumors (GCT) that may overexpress the proto-oncogene c-KIT, a receptor tyrosine kinase, of which dasatinib is a potent inhibitor. This retrospective review presents the feasibility and tolerability of dasatinib administration in select patients with CNS germinoma. Between November 2008 and April 2010, six patients with newly diagnosed (n = 3) or recurrent (n = 3) CNS GCT were treated in an effort to avoid irradiation and/or delay recurrence. The daily doses administered were 100-170 mg/m(2) with mostly grade 1-2 toxicities. Dasatinib may play a role in future treatment strategies for CNS GCT.
authors.affiliation: The Neuro-Oncology Program, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, California, USA.
authors.forename: Diana S
authors.initials: DS
authors.lastname: Osorio
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Finlay
authors.forename: Girish
authors.initials: G
authors.lastname: Dhall
authors.forename: Stewart
authors.initials: S
authors.lastname: Goldman
authors.forename: David
authors.initials: D
authors.lastname: Eisenstat
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Brown
mesh_terms: D000293:Adolescent; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D002648:Child; D000069439:Dasatinib; D005260:Female; D018237:Germinoma / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000188:drug therapy*; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage*; D000090063:Proto-Oncogene Mas; D011743:Pyrimidines / Q000008:administration & dosage*; D012189:Retrospective Studies; D013844:Thiazoles / Q000008:administration & dosage*
chemical_list: C000715470:MAS1 protein, human; D047428:Protein Kinase Inhibitors; D000090063:Proto-Oncogene Mas; D011743:Pyrimidines; D013844:Thiazoles; D000069439:Dasatinib
keywords: central nervous system; dasatinib; germ cell tumors; pediatrics