title: Impact of rotavirus vaccination in Australian children below 5 years of age: a database study.
abstract: This study was conducted to assess the impact of administration of two-dose rotavirus (RV) vaccine (RIX4414; GlaxoSmithKline Vaccines) among children aged less than 5 y in three states/territories of Australia. Aggregated and de-identified data on rotavirus gastroenteritis (RVGE) and all-cause gastroenteritis (AGE) from July 1998-June 2009 were obtained from the Australian Institute of Health and Welfare database. The baseline incidence (July 1998-June 2006) of RVGE hospitalizations before RV vaccine introduction in New South Wales (NSW), the Australian Capital Territory (ACT) and the Northern Territory (NT) were 33.75, 42.93 and 288.67 per 10,000 child-years, respectively among children aged 0-11 mo. Following RV vaccine introduction in NSW, the ACT and the NT, incidence of RVGE hospitalizations reduced to 13.06, 17.35 and 47.52 per 10,000 child-years, respectively, during July 2007-June 2008 and 3.87, 8.40 and 122.79 per 10,000 child-years, respectively, during July 2008-June 2009 among children aged 0-11 mo. Reductions in RVGE and AGE were also observed in all children below 5 y of age in NSW and the ACT. Overall reduction in hospitalizations due to RVGE and AGE was observed following RV vaccine introduction into the NIP in Australia.
authors.affiliation: GlaxoSmithKline Vaccines Pty Ltd; Melbourne, VIC Australia.
authors.forename: Annmarie
authors.initials: A
authors.lastname: Pendleton
authors.forename: Maja
authors.initials: M
authors.lastname: Galic
authors.forename: Christopher
authors.initials: C
authors.lastname: Clarke
authors.forename: Su Peing
authors.initials: SP
authors.lastname: Ng
authors.forename: Emilio
authors.initials: E
authors.lastname: Ledesma
authors.forename: Gunasekaran
authors.initials: G
authors.lastname: Ramakrishnan
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Liu
mesh_terms: D020958:Australian Capital Territory / Q000453:epidemiology; D002675:Child, Preschool; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology* / Q000517:prevention & control*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009517:New South Wales / Q000453:epidemiology; D015876:Northern Territory / Q000453:epidemiology; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014611:Vaccination / Q000379:methods* / Q000706:statistics & numerical data*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
chemical_list: C492457:RIX4414 vaccine; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated
keywords: Australia; gastroenteritis; hospitalization; incidence; rotavirus