title: [Research progress of signaling channels of mechanotransduction on keratinocytes].
abstract: OBJECTIVE
  To find new ways for wound healing and tissue expansion by reviewing of progress in recent years in functional molecules which are used for signaling channels of mechanical stress perception and mechanotransduction of keratinocyte.
  
  
  METHODS
  The domestic and international articles were reviewed to summarize the functional molecules and signaling channels of mechanical stress perception and mechanotransduction of keratinocytes.
  
  
  RESULTS
  The mechanism of mechanical stress perception includes mechano-sensitive channels, growth factor receptor-mediated mechanical stress perception, and mechanical stress perception by protein deformation. The mechanism of mechanotransduction includes cell adhesion-mediated signaling, mitogen-activated protein kinase signaling, the cytoskeleton and extracellular matrix, and so on.
  
  
  CONCLUSIONS
  Keratinocytes can response to the mechanical stress and transfer the effective information to undergo shaping, migration, proliferation, differentiation, and other biological behavior in order to adjust itself to adapt to the new environment.
authors.affiliation: Ninth Department of Plastic Surgery, Plastic Surgery Hospital of Chinese Academy of Medical Sciences, Beijing 100144, P.R.China.
authors.forename: Siqi
authors.initials: S
authors.lastname: Fu
authors.forename: Jincai
authors.initials: J
authors.lastname: Fan
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000378:metabolism / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation; D003599:Cytoskeleton / Q000378:metabolism / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D040542:Mechanotransduction, Cellular; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013314:Stress, Mechanical
chemical_list: D015220:Calcium Channels; D020928:Mitogen-Activated Protein Kinases