title: FGFR fusions in the driver's seat.
abstract: Through a clinical deep sequencing protocol, Wu and colleagues have identified multiple FGFR fusion proteins in diverse cancers. Pharmacologic inhibition of FGFR suppressed the growth of FGFR fusion-positive tumor models, suggesting that these FGFR fusions are oncogenic drivers and highlighting the use of streamlined clinical sequencing efforts to identify novel, actionable driver oncoproteins in human tumors.
authors.affiliation: Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA.
authors.forename: Amit J
authors.initials: AJ
authors.lastname: Sabnis
authors.forename: Trever G
authors.initials: TG
authors.lastname: Bivona
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D015514:Oncogene Proteins, Fusion / Q000037:antagonists & inhibitors / Q000378:metabolism*; D017468:Receptors, Fibroblast Growth Factor / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D015514:Oncogene Proteins, Fusion; D017468:Receptors, Fibroblast Growth Factor