title: Angiogenesis in liver metastasis of colo-rectal carcinoma.
abstract: In liver metastasis of color-rectal carcinoma, angiogenesis is supported by vascular endothelial growth factor (VEGF) and E-selectin while it is suppressed by Netrin-4 and LK-68. Sinusoidal endothelial cells and the hepatocyte-derived extracellular matrix support growth of microvessels in liver metastases of color-rectal cancers. Based on these insights, the new treatment for liver metastasis of color-rectal cancers target diverse pathways and molecules of angiogenesis, especially the VEGF pathway. Additional agents target the cyclooxygenase-2 pathway or follow regimens for inhibiting angiogenesis. In this review, we discuss angiogenesis and treatments avaiable for color-rectal liver metastasis.
authors.affiliation: Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical College, Guangzhou 510180, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Xu
authors.forename: Fei
authors.initials: F
authors.lastname: Shen
authors.forename: Jie
authors.initials: J
authors.lastname: Cao
authors.forename: Lin
authors.initials: L
authors.lastname: Jia
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply* / Q000556:secondary; D009389:Neovascularization, Pathologic / Q000188:drug therapy*
chemical_list: D020533:Angiogenesis Inhibitors