title: Electroretinographic responses in epileptic children treated with vigabatrin.
abstract: Vigabatrin is an antiepileptic drug that results in higher gamma-aminobutyrate levels in the brain and retina. Vigabatrin-induced visual field defects are usually asymptomatic and only detectable by perimetry. Further, perimetry requires good cooperation, and children aged under 10 years cannot do it. Electroretinogram response amplitude to full-field 30-Hz flicker shine has been offered to be more specific in predicting visual field defects. This study is scheduled to investigate the vigabatrin-associated visual complications in 67 epileptic children taking vigabatrin using full-field electroretinogram. Electroretinographic surveys showed normal range parameters despite 3 months of vigabatrin treatment, and just 3 (4.47%) children had been visually impaired at the end of 6-month treatment. Among these 3 cases, 1 patient had persistent electroretinogram abnormality despite vigabatrin discontinuation. Our study suggests that vigabatrin is secure for short-term pediatric antiepileptic treatment, with few cases of visual impairments and that are often reversible.
authors.affiliation: Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Dr.mkbakhshandehbali@yahoo.com.
authors.forename: M K
authors.initials: MK
authors.lastname: Bakhshandeh Bali
authors.affiliation: Brain and Spinal Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: S M Taheri
authors.initials: SM
authors.lastname: Otaghsara
authors.affiliation: Eye Research Center, Rasool Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Soltansanjari
authors.affiliation: Eye Research Center, Rasool Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Nadia
authors.initials: N
authors.lastname: Sadighi
authors.affiliation: Department of Pediatric Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Nasehi
authors.affiliation: Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahmoud Reza
authors.initials: MR
authors.lastname: Ashrafi
authors.affiliation: Department of Pediatric Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Karimzadeh
authors.affiliation: Department of Pediatric Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Taghdiri
authors.affiliation: Department of Pediatric Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ghofrani
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004596:Electroretinography; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D007223:Infant; D015835:Ocular Motility Disorders / Q000139:chemically induced* / Q000175:diagnosis*; D020888:Vigabatrin / Q000009:adverse effects*; D058609:Visual Field Tests
chemical_list: D000927:Anticonvulsants; D020888:Vigabatrin
keywords: electroretinogram; perimetry; vigabatrin