title: Orlistat improves endothelial function in obese adolescents: a randomised trial.
abstract: OBJECTIVE
  To investigate the effect of orlistat on endothelial function in obese adolescents.
  
  
  METHODS
  Single-blind 10-week controlled trial of 67 normolipidaemic obese adolescents randomised into three groups. Group 1 (diet alone), Group 2 (diet and orlistat), Group 3 (diet, orlistat and exercise). Endothelial function measured by flow-mediated dilatation (FMD) of the brachial artery, anthropometric parameters, blood pressure, fasting blood lipids, insulin and glucose levels were recorded at baseline and at 10 weeks.
  
  
  RESULTS
  Sixty four subjects completed the study. Groups were comparable at baseline. FMD increased significantly with orlistat (Groups 2 and 3) but not in Group 1. Orlistat treatment resulted in significantly reduced bodyweight, body mass index (BMI), waist circumference, total and low-density lipoprotein (LDL) cholesterol levels. High-density lipoprotein cholesterol levels were unchanged. Triglyceride and insulin levels were significantly reduced in all three groups. The reduction in cholesterols did not correlate with reductions in weight and BMI. A slight reduction of body fat, both with and without orlistat treatment, correlated with reduction in BMI after adjustment for baseline values. Blood pressure was unaltered by orlistat. Calorie intake was reduced with orlistat, and the decrease noted in % fat and increase in % carbohydrate was significant only in those taking orlistat. The addition of exercise (Group 3 compared with Group 2) altered no parameter.
  
  
  CONCLUSIONS
  Orlistat improves endothelial function and reduces bodyweight, BMI, fasting total and LDL-cholesterol in obese adolescents when combined with dietary control. Improvement in endothelial function if maintained could reflect long-term cardiovascular benefit.
authors.affiliation: Institute of Human Performance, The University of Hong Kong, Hong Kong.|Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Clare Cw
authors.initials: CC
authors.lastname: Yu
authors.affiliation: Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Albert M
authors.initials: AM
authors.lastname: Li
authors.affiliation: Institute of Human Performance, The University of Hong Kong, Hong Kong.
authors.forename: Karly Ow
authors.initials: KO
authors.lastname: Chan
authors.affiliation: Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Ping
authors.initials: P
authors.lastname: Chook
authors.affiliation: Institute of Human Performance, The University of Hong Kong, Hong Kong.
authors.forename: Jack Tc
authors.initials: JT
authors.lastname: Kam
authors.affiliation: Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Chun T
authors.initials: CT
authors.lastname: Au
authors.affiliation: Hong Kong Sports Institute, Hong Kong.
authors.forename: Raymond Ch
authors.initials: RC
authors.lastname: So
authors.affiliation: Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Rita Yt
authors.initials: RY
authors.lastname: Sung
authors.affiliation: Institute of Human Performance, The University of Hong Kong, Hong Kong.
authors.forename: Alison M
authors.initials: AM
authors.lastname: McManus
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001795:Blood Pressure Determination; D002648:Child; D042783:Endothelial Cells / Q000187:drug effects*; D002149:Energy Intake; D005215:Fasting / Q000097:blood; D005260:Female; D006723:Hong Kong; D006801:Humans; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity; D009765:Obesity / Q000178:diet therapy / Q000188:drug therapy*; D000077403:Orlistat
chemical_list: D019440:Anti-Obesity Agents; D007783:Lactones; D000077403:Orlistat
keywords: adolescent; endothelial function; obesity; orlistat; resistance training; weight loss