title: Demographic trends and disease-specific survival in salivary acinic cell carcinoma: an analysis of 1129 cases.
abstract: OBJECTIVE
  Acinic cell carcinoma (AciCC) is a rare salivary gland malignancy that most commonly arises in the parotid gland. Characteristics of AciCC are slow growth and a long clinical course. As a rare tumor, population-based studies are limited. We analyzed the incidence and survival for AciCC using a national population-based database.
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  The United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry was utilized to calculate incidence and disease-specific survival trends for AciCC between 1973 and 2009. Patient data were stratified according to age, gender, race, grade, and extent of disease. Incidence trends were studied across the last 30 years and long-term disease-specific survival outcomes were compared across the different demographic parameters.
  
  
  RESULTS
  A total of 1,129 cases of AciCC were identified, comprising of 672 (59.52%) females. Incidence trend analysis revealed significant changes in yearly incidence rates from 1973 to 2009 for male gender and white and "others" races. Overall 5-year survival was 97.15%, 10-year survival was 93.81%, and 20-year survival was 89.74%. Significant differences in survival outcomes were noted for extent of disease. Patients exhibiting distant metastasis displayed the worse long-term prognosis at 21.99% 20-year disease-specific survival. Hazard ratios demonstrated a significant increase in mortality in patients with poorly differentiated, undifferentiated, and metastatic disease.
  
  
  CONCLUSIONS
  Trends in incidence of AciCC are influenced by gender, race and age. Long-term survival of this rare malignant tumor is influenced by gender, grade, race, and extent of disease. Future studies need to be conducted to investigate these dynamic trends related to AciCC.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A.
authors.forename: Neal R
authors.initials: NR
authors.lastname: Patel
authors.forename: Saurin
authors.initials: S
authors.lastname: Sanghvi
authors.forename: Mohemmed N
authors.initials: MN
authors.lastname: Khan
authors.forename: Qasim
authors.initials: Q
authors.lastname: Husain
authors.forename: Soly
authors.initials: S
authors.lastname: Baredes
authors.forename: Jean Anderson
authors.initials: JA
authors.lastname: Eloy
mesh_terms: D018267:Carcinoma, Acinar Cell / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000453:epidemiology*; D015996:Survival Rate
keywords: Acinic cell carcinoma; cancer; demographic; disease-specific survival; incidence; malignancy; salivary gland