title: Parathyroid scintigraphy in renal hyperparathyroidism: the added diagnostic value of SPECT and SPECT/CT.
abstract: Secondary hyperparathyroidism (sHPT) is a major complication for patients with end-stage renal disease on long-term hemodialysis or peritoneal dialysis. When the disease is resistant to medical treatment, patients with severe sHPT are typically referred for parathyroidectomy (PTx), which usually improves biological parameters as well as clinical signs and symptoms. Unfortunately, early surgical failure with persistent disease may occur in 5%-10% of patients and recurrence reaches 20%-30% at 5 years. Presently, the use of parathyroid scintigraphy in sHPT is usually limited to the management of surgical failures after initial PTx. This review describes the strengths and limitations of typical (99m)Tc-sestamibi imaging protocols, and highlights the potential benefits of using parathyroid scintigraphy in the initial workup of surgical patients.
authors.affiliation: Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France.
authors.forename: David
authors.initials: D
authors.lastname: Taïeb
authors.forename: Pablo
authors.initials: P
authors.lastname: Ureña-Torres
authors.forename: Paolo
authors.initials: P
authors.lastname: Zanotti-Fregonara
authors.forename: Domenico
authors.initials: D
authors.lastname: Rubello
authors.forename: Alice
authors.initials: A
authors.lastname: Ferretti
authors.forename: Ioline
authors.initials: I
authors.lastname: Henter
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Henry
authors.forename: Francesca
authors.initials: F
authors.lastname: Schiavi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Opocher
authors.forename: Johan G
authors.initials: JG
authors.lastname: Blickman
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Colletti
authors.forename: Elif
authors.initials: E
authors.lastname: Hindié
mesh_terms: D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications / Q000000981:diagnostic imaging*; D007674:Kidney Diseases / Q000150:complications*; D064847:Multimodal Imaging / Q000379:methods*; D010280:Parathyroid Glands / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*