title: Interaction of metabolic syndrome with asthma in postmenopausal women: role of adipokines.
abstract: The increasing prevalence of both asthma and obesity are major health problems. Recent studies established a possible link between obesity and asthma; however, the underlying mechanism is not clear. The aim of the study was to analyze the prevalence of metabolic syndrome in postmenopausal subjects with asthma and search the interactions between adipokines, metabolic syndrome, and asthma. A total of 45 female patients (57.5 ± 13.9 years) with asthma and 30 healthy subjects (59.6 ± 12.8 years) in postmenopausal status were enrolled in this study. For the diagnosis of metabolic syndrome, modified World Health Organization diagnostic criteria were used. Blood levels of glucose, lipid profile, HbA1c, insulin, CRP, leptin, adiponectin, tumor necrosis factor-alpha, interleukin (IL)-6, IL-8 and plasminogen activator inhibitor-1 (PAI-1) were measured. The mean body mass index was 29.6 ± 5.4 for asthma patients and 28.2 ± 5.3 for the control group. The incidence of metabolic syndrome was found as 26 % for both groups. Insulin resistance as calculated by homeostasis model assessment (HOMA-IR) and fasting insulin levels were significantly higher in asthma patients (p < 0.001 for both parameters). Leptin levels were significantly higher (p = 0.001) and adiponectin levels were lower (p = 0.029) in asthma patients compared to controls. We concluded that although incidence of obesity and metabolic syndrome was not higher in postmenopausal asthma patients than controls, there was an impairment of glucose metabolism and altered adipokine levels in asthma patients.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Namık Kemal University, Namık Kemal Mahallesi Kampus Caddesi No. 1, 59100, Merkez-Tekirdag, Turkey, drmurataydin@hotmail.com.
authors.forename: Murat
authors.initials: M
authors.lastname: Aydin
authors.forename: Cemile
authors.initials: C
authors.lastname: Koca
authors.forename: Duygu
authors.initials: D
authors.lastname: Ozol
authors.forename: Sema
authors.initials: S
authors.lastname: Uysal
authors.forename: Zeki
authors.initials: Z
authors.lastname: Yildirim
authors.forename: Havva Sahin
authors.initials: HS
authors.lastname: Kavakli
authors.forename: M Ramazan
authors.initials: MR
authors.lastname: Yigitoglu
mesh_terms: D052242:Adiponectin / Q000097:blood*; D001249:Asthma / Q000097:blood / Q000453:epidemiology*; D001786:Blood Glucose; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity; D017698:Postmenopause
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D020738:Leptin; D008055:Lipids