title: μ-Opioid receptor gene (OPRM1) polymorphism A118G: lack of association in Finnish populations with alcohol dependence or alcohol consumption.
abstract: OBJECTIVE
  The molecular epidemiological studies on the association of the opioid receptor µ-1 (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) and alcohol use disorders have given conflicting results. The aim of this study was to test the possible association of A118G polymorphism and alcohol use disorders and alcohol consumption in three large cohort-based study samples.
  
  
  METHODS
  The association between the OPRM1 A118G (Asn40Asp, rs1799971) polymorphism and alcohol use disorders and alcohol consumption was analyzed using three different population-based samples: (a) a Finnish cohort study, Health 2000, with 503 participants having a DSM-IV diagnosis for alcohol dependence and/or alcohol abuse and 506 age- and sex-matched controls; (b) a Finnish cohort study, FINRISK (n = 2360) and (c) the Helsinki Birth Cohort Study (n = 1384). The latter two populations lacked diagnosis-based phenotypes, but included detailed information on alcohol consumption.
  
  
  RESULTS
  We found no statistically significant differences in genotypic or allelic distribution between controls and subjects with alcohol dependence or abuse diagnoses. Likewise no significant effects were observed between the A118G genotype and alcohol consumption.
  
  
  CONCLUSIONS
  These results suggest that A118G (Asn40Asp) polymorphism may not have a major effect on the development of alcohol use disorders at least in the Finnish population.
authors.affiliation: Ministry of Social Affairs and Health, Department of Occupational Safety and Health, PO Box 33, FI-00023 Government, Finland.
authors.forename: Noora
authors.initials: N
authors.lastname: Rouvinen-Lagerström
authors.forename: Jari
authors.initials: J
authors.lastname: Lahti
authors.forename: Hannu
authors.initials: H
authors.lastname: Alho
authors.forename: Leena
authors.initials: L
authors.lastname: Kovanen
authors.forename: Mauri
authors.initials: M
authors.lastname: Aalto
authors.forename: Timo
authors.initials: T
authors.lastname: Partonen
authors.forename: Kaisa
authors.initials: K
authors.lastname: Silander
authors.forename: David
authors.initials: D
authors.lastname: Sinclair
authors.forename: Katri
authors.initials: K
authors.lastname: Räikkönen
authors.forename: Johan G
authors.initials: JG
authors.lastname: Eriksson
authors.forename: Aarno
authors.initials: A
authors.lastname: Palotie
authors.forename: Seppo
authors.initials: S
authors.lastname: Koskinen
authors.forename: Sirkku T
authors.initials: ST
authors.lastname: Saarikoski
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000235:genetics*; D000437:Alcoholism / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011159:Population Surveillance; D017450:Receptors, Opioid, mu / Q000235:genetics*
chemical_list: C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu