title: Efficacy of emodepside plus toltrazuril oral suspension for dogs (Procox®, Bayer) against Trichuris vulpis in naturally infected dogs.
abstract: The efficacy of emodepside plus toltrazuril oral suspension for dogs (Procox®, Bayer) against Trichuris vulpis was evaluated in a controlled, blinded and randomised laboratory study. Twenty naturally infected dogs were included. Dogs in the treatment group received the minimum therapeutic dose of 0.45 mg emodepside and 9 mg toltrazuril per kg body weight, while dogs in the control group were left untreated. Efficacy was calculated based on worm counts after necropsy on Day 7 post treatment. Additionally, all faeces were collected and examined for expelled worms. The treatment was 100 % effective. A total of 233 adult worms (geometric mean 17.0) and 3 immature adult worms were found in the control group at necropsy. Adequacy of infection was demonstrated. The treated group excreted a total of 186 adult worms within 2 days after treatment. Additionally, all dogs were co-infected with Uncinaria stenocephala. Efficacy against this parasite was 99.8 %. No side effects of the treatment were observed. This study demonstrates that in addition to the formerly proven efficacy against Toxocara canis, Ancylostoma caninum and Uncinaria stenocephala, emodepside plus toltrazuril suspension is also effective against T. vulpis and thus represents a convenient treatment option for dogs co-infected with whipworms and coccidia.
authors.affiliation: Bayer Animal Health GmbH, Leverkusen, Germany. gabriele.petry@bayer.com
authors.forename: Gabriele
authors.initials: G
authors.lastname: Petry
authors.forename: Gertraut
authors.initials: G
authors.lastname: Altreuther
authors.forename: Sonja
authors.initials: S
authors.lastname: Wolken
authors.forename: Petro
authors.initials: P
authors.lastname: Swart
authors.forename: Dawie J
authors.initials: DJ
authors.lastname: Kok
mesh_terms: D000284:Administration, Oral; D000723:Ancylostomatoidea / Q000302:isolation & purification; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000009:adverse effects; D060085:Coinfection / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D047630:Depsipeptides / Q000008:administration & dosage* / Q000009:adverse effects; D004285:Dogs; D004311:Double-Blind Method; D004338:Drug Combinations; D064420:Drug-Related Side Effects and Adverse Reactions; D005243:Feces / Q000469:parasitology; D059208:Parasite Load; D013535:Suspensions / Q000008:administration & dosage*; D016896:Treatment Outcome; D014227:Triazines / Q000008:administration & dosage* / Q000009:adverse effects; D014257:Trichuriasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D014258:Trichuris / Q000302:isolation & purification
chemical_list: D000871:Anthelmintics; D047630:Depsipeptides; D004338:Drug Combinations; D013535:Suspensions; D014227:Triazines; C036670:toltrazuril; C468987:emodepside