title: Sunitinib as an anti-endometriotic agent.
abstract: Endometriosis is one of the most frequent diseases in gynecology. Currently available medical therapies for this disease are unsatisfactory. Based on current understanding of the pathogenic mechanisms in endometriosis especially the similarity between this disease and cancer, this study was designed to investigate the efficacy of the anticancer drug sunitinib in treating endometriosis. The effect of sunitinib on regression of endometriotic implants was studied in a rat surgical model. Sunitinib reduced cyst cross sectional area by 78.8% and caused complete cyst disappearance in 50% of the animals. Histologically, extensive fibrosis was detected in sunitinib-treated group with positive reaction in TUNEL assay indicating that apoptosis is a mechanism of action.
authors.affiliation: Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan. manabbas@yahoo.com
authors.forename: Manal A
authors.initials: MA
authors.lastname: Abbas
authors.forename: Ahmad M
authors.initials: AM
authors.lastname: Disi
authors.forename: Mutasem O
authors.initials: MO
authors.lastname: Taha
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D004715:Endometriosis / Q000188:drug therapy* / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism; D005260:Female; D020287:In Situ Nick-End Labeling; D007211:Indoles / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011758:Pyrroles / Q000627:therapeutic use; D051381:Rats; D000077210:Sunitinib
chemical_list: D007211:Indoles; D047428:Protein Kinase Inhibitors; D011758:Pyrroles; D000077210:Sunitinib
keywords: Apoptosis; Endometriosis; Rat surgical model; Sunitinib