title: The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer's disease.
abstract: The present study examined the effects of Gouqi (Lycium barbarum) on the learning and memory abilities of an APP/PS1 double transgenic mouse model of Alzheimer's disease. We employed a Morris water maze to examine the spatial memory in this mice line with or without Gouqi extracts treatment. We identified that 2 weeks of oral administration of Gouqi extracts at 10 mg/kg improved the performance of the APP/PS1 mice in the learning and the memory retrieval phases of the Morris maze. In correlation with this, the levels of Aβ(1-42) in hippocampal tissue were reduced by the Gouqi treatment. We conclude that pharmacological treatment with Gouqi extracts is beneficial at the later stages of Alzheimer's disease.
authors.affiliation: Department of Neurology, Renmin's Hospital, Zhengzhou, Henan 450006;
authors.forename: Qianlin
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: DU
authors.forename: Yuping
authors.initials: Y
authors.lastname: Xu
authors.forename: Lei
authors.initials: L
authors.lastname: Dang
authors.forename: Li
authors.initials: L
authors.lastname: Xiang
authors.forename: Jiewen
authors.initials: J
authors.lastname: Zhang
keywords: Alzheimer’s disease; Gouqi; Morris maze; learning; memory