title: Realtime adherence monitoring of antiretroviral therapy among HIV-infected adults and children in rural Uganda.
abstract: A real-time wireless electronic adherence monitor (EAM) and weekly self-report of missed doses via interactive voice response (IVR) and short message service (SMS) queries were used to measure antiretroviral therapy adherence in 49 adults and 46 children in rural Uganda. Median adherence was 89.5% among adults and 92.8% among children by EAM, and 99-100% for both adults and children by IVR/SMS self-report. Loss of viral suppression was significantly associated with adherence by EAM (odds ratio 0.58 for each 10% increase), but not IVR/SMS. Wireless EAM creates an exciting opportunity to monitor and potentially intervene with adherence challenges as they are happening.
authors.affiliation: aMassachusetts General Hospital bHarvard Medical School, Boston cRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA dMbarara University of Science and Technology, Mbarara, Uganda eUniversity of California, San Francisco, California, USA.
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Haberer
authors.forename: Julius
authors.initials: J
authors.lastname: Kiwanuka
authors.forename: Denis
authors.initials: D
authors.lastname: Nansera
authors.forename: Conrad
authors.initials: C
authors.lastname: Muzoora
authors.forename: Peter W
authors.initials: PW
authors.lastname: Hunt
authors.forename: Jacquelyn
authors.initials: J
authors.lastname: So
authors.forename: Michael
authors.initials: M
authors.lastname: O'Donnell
authors.forename: Mark
authors.initials: M
authors.lastname: Siedner
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Martin
authors.forename: David R
authors.initials: DR
authors.lastname: Bangsberg
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D002648:Child; D015331:Cohort Studies; D005260:Female; D006678:HIV / Q000302:isolation & purification; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D017010:Reminder Systems; D012424:Rural Population; D014454:Uganda; D019562:Viral Load; D016903:Drug Monitoring
chemical_list: D044966:Anti-Retroviral Agents