title: Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".
abstract: Egawa et al. recently showed the value of patient-specific induced pluripotent stem cells (iPSCs) for modeling amyotrophic lateral sclerosis in vitro. Their study and our work highlight the need for complementary assays to detect small, but potentially important, phenotypic differences between control iPSC lines and those carrying disease mutations.
authors.forename: Bilada
authors.initials: B
authors.lastname: Bilican
authors.forename: Andrea
authors.initials: A
authors.lastname: Serio
authors.forename: Sami J
authors.initials: SJ
authors.lastname: Barmada
authors.forename: Agnes Lumi
authors.initials: AL
authors.lastname: Nishimura
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Sullivan
authors.forename: Monica
authors.initials: M
authors.lastname: Carrasco
authors.forename: Hemali P
authors.initials: HP
authors.lastname: Phatnani
authors.forename: Clare A
authors.initials: CA
authors.lastname: Puddifoot
authors.forename: David
authors.initials: D
authors.lastname: Story
authors.forename: Judy
authors.initials: J
authors.lastname: Fletcher
authors.forename: In-Hyun
authors.initials: IH
authors.lastname: Park
authors.forename: Brad A
authors.initials: BA
authors.lastname: Friedman
authors.forename: George Q
authors.initials: GQ
authors.lastname: Daley
authors.forename: David J A
authors.initials: DJ
authors.lastname: Wyllie
authors.forename: Giles E
authors.initials: GE
authors.lastname: Hardingham
authors.forename: Ian
authors.initials: I
authors.lastname: Wilmut
authors.forename: Steven
authors.initials: S
authors.lastname: Finkbeiner
authors.forename: Tom
authors.initials: T
authors.lastname: Maniatis
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Shaw
authors.forename: Siddharthan
authors.initials: S
authors.lastname: Chandran
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D009046:Motor Neurons / Q000166:cytology*