title: MicroRNAs: Biomarkers for cardiovascular disease in patients with diabetes mellitus.
abstract: Diabetes mellitus (DM) is a complex metabolic disorder characterized by low insulin production/secretion by pancreatic beta cells and/or low responsiveness by insulin target tissues MicroRNAs have been associated with DM, but it is not clear whether this is a cause or an effect of metabolic abnormalities related to DM. In the hyperglycemic environment miRNAs are in involved in multiple stages of cardiovascular disease development and progression. In diabetic patients with cardiovascular disease miRNAs could potentially serve as early biomarkers for diagnosis and as therapeutic agents. The current review focuses on the involvement of miRNAs in molecular mechanisms underlying the pathogenesis of DM and its cardiovascular complications.
authors.affiliation: University of Chicago Medical Center, Department of Medicine, 5841 S. Maryland Ave, Chicago, IL 60637, USA. alexbriasoulis@uchicago.edu
authors.forename: Alexandros
authors.initials: A
authors.lastname: Briasoulis
authors.forename: Dimitris
authors.initials: D
authors.lastname: Tousoulis
authors.forename: Georgia
authors.initials: G
authors.lastname: Vogiatzi
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Siasos
authors.forename: Nikos
authors.initials: N
authors.lastname: Papageorgiou
authors.forename: Evangelos
authors.initials: E
authors.lastname: Oikonomou
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Genimata
authors.forename: Theodosia
authors.initials: T
authors.lastname: Konsola
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs