title: TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion.
abstract: Adrenomedullin (AM) is a 52-amino acid peptide initially isolated from human pheochromocytoma. AM is expressed in a variety of malignant tissues and cancer cell lines and was shown to be a mitogenic factor capable of stimulating growth of several cancer cell types. In addition, AM is a survival factor for certain cancer cells. Some data suggest that AM might be involved in the progression cancer metastasis via angiogenesis and cell migration and invasion control. The Transient Receptor Potential channel TRPV2 is known to promote in prostate cancer cell migration and invasive phenotype and is correlated with the stage and grade of bladder cancer. In this work we show that AM induces prostate and urothelial cancer cell migration and invasion through TRPV2 translocation to plasma membrane and the subsequent increase in resting calcium level.
authors.affiliation: INSERM U1003, Equipe Labellisée par la Ligue Nationale contre le Cancer, Villeneuve d'Ascq, France.
authors.forename: Agathe
authors.initials: A
authors.lastname: Oulidi
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bokhobza
authors.forename: Dimitra
authors.initials: D
authors.lastname: Gkika
authors.forename: Fabien
authors.initials: F
authors.lastname: Vanden Abeele
authors.forename: V'yacheslav
authors.initials: V
authors.lastname: Lehen'kyi
authors.forename: L'houcine
authors.initials: L
authors.lastname: Ouafik
authors.forename: Brigitte
authors.initials: B
authors.lastname: Mauroy
authors.forename: Natalia
authors.initials: N
authors.lastname: Prevarskaya
mesh_terms: D053607:Adrenomedullin / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects / Q000235:genetics; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement / Q000187:drug effects / Q000235:genetics; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology*; D021381:Protein Transport; D015398:Signal Transduction; D050916:TRPV Cation Channels / Q000235:genetics* / Q000378:metabolism; D014523:Urethral Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology
chemical_list: D050916:TRPV Cation Channels; C400769:TRPV2 protein, human; D053607:Adrenomedullin; D019869:Phosphatidylinositol 3-Kinases