title: Differentiated control of deranged nitric oxide metabolism: a therapeutic option in sepsis?
abstract: Derangement of nitric oxide (NO) metabolism represents one of the key mechanisms contributing to macro- and microcirculatory failure in sepsis. Sepsis-related therapy combining fluid resuscitation with administration of vasopressor and inotropic agents, however, does not guarantee correction of maldistributed nutritive perfusion between and within organs. Therefore, the differentiated and selective pharmacologic modulation of NO-mediated vascular function could play a useful role in hemodynamic management of patients with sepsis. This viewpoint carefully evaluates the potential role of intentionally using partially opposing effects of NO donors and NO synthase inhibitors to complement current therapy of hemodynamic stabilization in patients with sepsis.
authors.forename: Corinna
authors.initials: C
authors.lastname: Lupp
authors.forename: Silke
authors.initials: S
authors.lastname: Baasner
authors.forename: Can
authors.initials: C
authors.lastname: Ince
authors.forename: Frank
authors.initials: F
authors.lastname: Nocken
authors.forename: John F
authors.initials: JF
authors.lastname: Stover
authors.forename: Martin
authors.initials: M
authors.lastname: Westphal
mesh_terms: D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000494:pharmacology / Q000627:therapeutic use; D018805:Sepsis / Q000378:metabolism* / Q000628:therapy*
chemical_list: D020030:Nitric Oxide Donors; D009569:Nitric Oxide