title: Nutritional status and metabolic disorders in HIV-exposed uninfected prepubertal children.
abstract: OBJECTIVE
  The objective of the study was to assess the nutritional status and metabolic alterations in HIV-exposed uninfected (HIVe) children compared with HIV-unexposed (HIVn) children.
  
  
  METHODS
  A cross-sectional study was carried out with 76 children distributed into two groups: HIVe (n = 31) and HIVn (n = 45). Biochemical data (hematologic test, lipid profile, insulin resistance, hepatic profile, and C-reactive protein) were evaluated. Anthropometric parameters and body composition analyses were performed.
  
  
  RESULTS
  The groups were similar regarding body mass index-for-age z-scores (P = 0.297) and height-for-age z-scores (P = 0.666). HIVe had a higher dyslipidemia prevalence (38.7% versus 11.1%; P = 0.010), altered total cholesterol (TC) values (19.4% versus 2.2%; P = 0.016) higher LDL-C mean levels (97.8 mg/dl versus 86 mg/dl; P = 0.028), borderline low-density lipoprotein cholesterol (LDL-C) (40% versus 14%; P = 0.011) and TC (41.9% versus 20%; P = 0.038) compared with HIVn.
  
  
  CONCLUSIONS
  Despite the similar nutritional status between groups, our data clearly demonstrated a higher prevalence of dyslipidemia, altered TC, higher LDL-C levels and also LDL-C and TC borderline values in HIVe children.
authors.affiliation: Division of Nutrition, Department of Pediatrics, UNIFESP/EPM, São Paulo, Brazil.
authors.forename: Cristiane Chiantelli
authors.initials: CC
authors.lastname: Claudio
authors.forename: Rose Vega
authors.initials: RV
authors.lastname: Patin
authors.forename: Cecília Zanin
authors.initials: CZ
authors.lastname: Palchetti
authors.forename: Daisy Maria
authors.initials: DM
authors.lastname: Machado
authors.forename: Regina Célia de Menezes
authors.initials: RC
authors.lastname: Succi
authors.forename: Fernanda Luisa Ceragioli
authors.initials: FL
authors.lastname: Oliveira
mesh_terms: D000886:Anthropometry; D001823:Body Composition; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008659:Metabolic Diseases / Q000150:complications / Q000503:physiopathology*; D009752:Nutritional Status; D015995:Prevalence; D011795:Surveys and Questionnaires
chemical_list: D002097:C-Reactive Protein; D002784:Cholesterol