title: Mesenchymal stem cells, aging and regenerative medicine.
abstract: Tissue maintenance and regeneration is dependent on stem cells and increasing evidence has shown to decline with age. Stem cell based-aging is thought to influence therapeutic efficacy. Mesenchymal stromal cells (MSCs) are involved in tissue regeneration. Here, we discuss the effects of age-related changes on MSC properties considering their possible use in research or regenerative medicine.
authors.affiliation: Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, USA.
authors.forename: Chiara
authors.initials: C
authors.lastname: Raggi
authors.forename: Anna C
authors.initials: AC
authors.lastname: Berardi
keywords: aging; mesenchymal stem cells (MSCs); regenerative medicine; stem cells