title: Dioxin-like compounds are not associated with bone strength measured by ultrasonography in Inuit women from Nunavik (Canada): results of a cross-sectional study.
abstract: BACKGROUND
  Bone strength in Inuit people appears lower than that of non-Aboriginals. Inuit are exposed to persistent organic pollutants including dioxin-like compounds (DLCs) through their traditional diet that comprises predatory fish and marine mammal fat. Results from experimental and population studies suggest that some DLCs can alter bone metabolism and increase bone fragility.
  
  
  OBJECTIVE
  This cross-sectional descriptive study was conducted to examine the relationship between the stiffness index (SI) and plasma concentrations of total DLCs or specific dioxin-like polychlorinated biphenyls (DL-PCBs) in Inuit women of Nunavik (Northern Quebec, Canada).
  
  
  METHODS
  SI was determined by ultrasonography at the right calcaneus of 194 Inuit women aged 35-72 years who participated to Qanuippitaa? How Are We? Nunavik Inuit Health Survey in 2004. Plasma total DLC levels were quantified by measuring the aryl hydrocarbon receptor-mediated transcriptional activity elicited by plasma sample extracts in a cell-based reporter gene assay. Plasma concentrations of DL-PCBs nos. 105, 118, 156, 157, 167 and 189 were measured by gas chromatography-mass spectrometry. We used multiple linear regression analyses to investigate relations between total DLCs or specific DL-PCBs and SI, taking into consideration several potential confounders.
  
  
  RESULTS
  Neither total plasma DLCs nor specific DL-PCBs were associated with SI after adjustment for several confounders and covariates.
  
  
  CONCLUSIONS
  Our results do not support a relation between exposure to DLCs and bone strength measured by ultrasonography in Inuit women of Nunavik.
authors.affiliation: Axe santé publique et pratiques optimales en santé, Centre de recherche du CHU de Québec, Québec, Canada.
authors.forename: Alexandra-Cristina
authors.initials: AC
authors.lastname: Paunescu
authors.forename: Pierre
authors.initials: P
authors.lastname: Ayotte
authors.forename: Eric
authors.initials: E
authors.lastname: Dewailly
authors.forename: Sylvie
authors.initials: S
authors.lastname: Dodin
mesh_terms: D000328:Adult; D000368:Aged; D001110:Arctic Regions / Q000453:epidemiology; D001847:Bone Diseases / Q000139:chemically induced; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000503:physiopathology; D002111:Calcaneus / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002170:Canada / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004032:Diet; D004147:Dioxins / Q000009:adverse effects / Q000097:blood*; D004781:Environmental Exposure / Q000032:analysis; D004785:Environmental Pollutants / Q000097:blood; D005260:Female; D006801:Humans; D004930:Inuit; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000009:adverse effects / Q000097:blood*; D014463:Ultrasonography
chemical_list: D004147:Dioxins; D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls
keywords: Inuit women; bone strength; dioxin-like compounds; polychlorinated biphenyls; stiffness index