title: Periodontal disease as a potential factor for systemic inflammatory response in the dog.
abstract: Periodontal disease is an inflammatory disease that has numerous consequences both locally and systemically The aim of this study was to assess whether periodontal disease causes systemic inflammatory response in otherwise healthy, adult dogs. We estimated the total mouth periodontal score (TMPS), measured the concentration of C-reactive protein (CRP), hematocrit, and albumin, and determined the white blood cell (WBC) and polymorphonuclear cell (PMN) counts in client-owned dogs. There was a statistically significant relationship between the gingival bleeding index (TMPS-G) and CRP concentration, and WBC and PMN counts, possibly during the active periods of periodontal tissue destruction. No correlation was found between the periodontal destruction index (TMPS-P) and the measured blood parameters. We conclude that chronic periodontal disease does not cause anemia or a reduction in serum albumin. However, active periods of periodontal inflammation may be associated with laboratory values suggestive of a systemic inflammatory response.
authors.affiliation: Companion Animal Clinic, Department of Clinical Science, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: M I
authors.initials: MI
authors.lastname: Kouki
authors.forename: S A
authors.initials: SA
authors.lastname: Papadimitriou
authors.forename: G M
authors.initials: GM
authors.lastname: Kazakos
authors.forename: I
authors.initials: I
authors.lastname: Savas
authors.forename: D
authors.initials: D
authors.lastname: Bitchava
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis; D004283:Dog Diseases / Q000097:blood; D004285:Dogs; D005260:Female; D005884:Gingival Hemorrhage / Q000662:veterinary; D005891:Gingivitis / Q000662:veterinary; D006400:Hematocrit / Q000662:veterinary; D007249:Inflammation / Q000097:blood / Q000662:veterinary*; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D009504:Neutrophils / Q000473:pathology; D017622:Periodontal Attachment Loss / Q000662:veterinary; D010510:Periodontal Diseases / Q000097:blood / Q000662:veterinary*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000662:veterinary; D012709:Serum Albumin / Q000032:analysis
chemical_list: D012709:Serum Albumin; D002097:C-Reactive Protein