title: Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease.
abstract: Natural self-reactive antibodies in the peripheral blood may play a considerable role in the control of potentially toxic proteins that may otherwise accumulate in the aging brain. The significance of serum antibodies reactive against α-synuclein is not well known. We explored serum IgG levels to monomeric α-synuclein in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) with a novel and validated highly sensitive ELISA assay. Antibody levels revealed stark differences in patients compared to healthy subjects and were dependent on diagnosis, disease duration and age. Anti-α-synuclein IgG levels were increased in both patient groups, but in early DLB to a much greater extent than in AD. Increased antibody levels were most evident in younger patients, while with advanced age relatively low levels were observed, similar to healthy individuals, exhibiting stable antibody levels independent of age. Our data show the presence of differentially altered IgG levels against α-synuclein in DLB and AD, which may relate to a disturbed α-synuclein homeostasis triggered by the disease process. These observations may foster the development of novel, possibly preclinical biomarkers and immunotherapeutic strategies that target α-synuclein in neurodegenerative disease.
authors.affiliation: Department of Psychiatry and Psychotherapy, Eberhard-Karls-University, Tübingen, Germany. niklaskoehler@yahoo.com
authors.forename: Niklas K U
authors.initials: NK
authors.lastname: Koehler
authors.forename: Elke
authors.initials: E
authors.lastname: Stransky
authors.forename: Mona
authors.initials: M
authors.lastname: Shing
authors.forename: Susanne
authors.initials: S
authors.lastname: Gaertner
authors.forename: Mirjam
authors.initials: M
authors.lastname: Meyer
authors.forename: Brigitte
authors.initials: B
authors.lastname: Schreitmüller
authors.forename: Thomas
authors.initials: T
authors.lastname: Leyhe
authors.forename: Christoph
authors.initials: C
authors.lastname: Laske
authors.forename: Walter
authors.initials: W
authors.lastname: Maetzler
authors.forename: Phillipp
authors.initials: P
authors.lastname: Kahle
authors.forename: Maria S
authors.initials: MS
authors.lastname: Celej
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Jovin
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Fallgatter
authors.forename: Anil
authors.initials: A
authors.lastname: Batra
authors.forename: Gerhard
authors.initials: G
authors.lastname: Buchkremer
authors.forename: Klaus
authors.initials: K
authors.lastname: Schott
authors.forename: Elke
authors.initials: E
authors.lastname: Richartz-Salzburger
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000276:immunology / Q000473:pathology; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D016022:Case-Control Studies; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D020961:Lewy Body Disease / Q000097:blood* / Q000276:immunology / Q000473:pathology; D008297:Male; D012720:Severity of Illness Index; D051844:alpha-Synuclein / Q000097:blood* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D051844:alpha-Synuclein