title: Anti-melanogenesis constituents from the seaweed Dictyota coriacea.
abstract: This study was conducted to identify the anti-melanogenesis constituents from a seaweed Dictyota coriacea (Holmes). Three known compounds, viz. 1,9-dihydroxycrenulide (1), epiloliolide (2) and D-mannitol (3), were isolated from the ethanol extract. The melanin synthesis inhibition activities were evaluated using B16F10 melanoma cells for the isolates. Compared with the positive control, arbutin, compounds 1 and 2 exhibited more potency, showing 27.8 and 22.6% inhibition activities at a substrate concentration of 30 microg/mL. Our studies also indicate that these compounds are not cytotoxic. Hence, they might prove to be useful therapeutic agents for treating hyperpigmentation and effective components of whitening cosmetics.
authors.affiliation: Bio-Conversion Center, Jeju Technopark, Jeju 690-121, Korea.
authors.forename: Ryeo Kyeong
authors.initials: RK
authors.lastname: Ko
authors.forename: Min-Chul
authors.initials: MC
authors.lastname: Kang
authors.forename: Sang Suk
authors.initials: SS
authors.lastname: Kim
authors.forename: Tae Heon
authors.initials: TH
authors.lastname: Oh
authors.forename: Gi-Ok
authors.initials: GO
authors.lastname: Kim
authors.forename: Chang-Gu
authors.initials: CG
authors.lastname: Hyun
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Hyun
authors.forename: Nam Ho
authors.initials: NH
authors.lastname: Lee
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051379:Mice; D012624:Seaweed / Q000737:chemistry*
chemical_list: D008543:Melanins