title: Laser microstructured biodegradable scaffolds.
abstract: The two-photon polymerization technique (2PP) uses non-linear absorption of femtosecond laser pulses to selectively polymerize photosensitive materials. 2PP has the ability to fabricate structures with a resolution from tens of micrometers down to hundreds of nanometers. Three-dimensional microstructuring by the 2PP technique provides many interesting possibilities for biomedical applications. This microstructuring technique is suitable with many biocompatible polymeric materials, such as polyethylene glycol, polylactic acid, polycaprolactone, gelatin, zirconium-based hybrids, and others. The process of fabrication does not require clean room conditions and does not use hazard chemicals or high temperatures. The most beneficial property of 2PP is that it is capable of producing especially complex three-dimensional (3-D) structures, including devices with overhangs, without using any supportive structure. The flexibility in controlling geometries and feature sizes and the possibility to fabricate structures without the addition of new material layers makes this technique particularly appealing for fabrication of 3-D scaffolds for tissue engineering.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Koroleva
authors.forename: Olga
authors.initials: O
authors.lastname: Kufelt
authors.forename: Sabrina
authors.initials: S
authors.lastname: Schlie-Wolter
authors.forename: Ulf
authors.initials: U
authors.lastname: Hinze
authors.forename: Boris
authors.initials: B
authors.lastname: Chichkov
mesh_terms: D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000737:chemistry* / Q000528:radiation effects; D007834:Lasers; D054802:Molecular Imprinting / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects; D011474:Prosthesis Design; D011829:Radiation Dosage; D013499:Surface Properties / Q000528:radiation effects; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials