title: Association analysis of two candidate polymorphisms in the tumour necrosis factor-α gene with osteoarthritis in a Chinese population.
abstract: OBJECTIVE
  The purpose of this study was to investigate the possible association between single nucleotide polymorphisms (SNPs) rs1800629 (TNF-α -308) and rs361525 (TNF-α -238) of the tumour necrosis factor (TNF)-α gene and susceptibility to osteoarthritis (OA) in the Han Chinese population.
  
  
  METHODS
  The TNF-α -308 and -238 genotypes were determined by TaqMan assay in 200 OA cases and 305 controls. Odds ratios (ORs) for OA and 95% confidence intervals (CIs) from unconditional logistic regression models were used to evaluate relative risks.
  
  
  RESULTS
  The frequencies of the allele 'A' of rs1800629 were 16% and 8.85% in OA cases and in controls, respectively, and thus the -308A allele had a 1.9612-fold (95% CI = 1.3323-2.8869, P < 0.001) increased risk for OA as compared to the -308G allele. However, no significant differences were found in the genotype and allele frequencies for rs361525 between OA and HC groups.
  
  
  CONCLUSIONS
  In the Han Chinese population, the allele 'A' of TNF-α -308 may increase the risk for OA, whereas TNF-α -238 polymorphisms do not play a role in OA patients.
authors.affiliation: Department of Orthopaedic Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No.164, Lanxi Road, Putuo District, 200062, Shanghai, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Ji
authors.forename: Jixiang
authors.initials: J
authors.lastname: Shi
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Cheng
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhou
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhou
authors.forename: Chengfu
authors.initials: C
authors.lastname: Cao
authors.forename: Jinhui
authors.initials: J
authors.lastname: Pang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha