title: [Trends in the use of antihypertensive drugs in France from 2002 to 2012: FLAHS surveys].
abstract: OBJECTIVE
  To evaluate from studies conducted between 2002 and 2012, trends in the use of antihypertensive drugs in France.
  
  
  METHODS
  French League Against Hypertension Survey (FLAHS) were conducted in a representative sample of subjects aged 35 and over living in France. A list including the names for all antihypertensive drugs marketed at the time of each survey made it possible to detail drug therapies employed. Data analysis has taken the patient as a unity. The data obtained in 2002, 2007 and 2012 are subject to this analysis.
  
  
  RESULTS
  In 2012, 30% of the French population aged 35 and older was treated with antihypertensive drugs (11.4 million), while 24% were treated in 2002 (8.2 million). On average, prescription of antihypertensive included 1.4 ± 0.7 pills in 2002, 1.5 ± 0.8 in 2007 and 1.8 ± 0.9 in 2012, which corresponds to a pharmacological monotherapy prescribed in 47% of subjects in 2012, a different percentage than in 2007 (46%) and 2002 (56%). Over the period, the percentage of prescriptions of diuretics (41% to 42%) and ACE inhibitors (24% to 23%) and beta-blockers (35% to 36%) is stable, but they are increasing with ARBs (23% to 47%) and calcium antagonists (24% to 34%). The prescriptions of fixed-dose combinations were also increased (19% to 30%). In 2012, fixed-dose combinations included a diuretic (79%), an ARB (65%), an ACEI (23%) and a calcium antagonist (20%). Blood pressure control estimated with home blood pressure monitoring increases from 38% in 2002 to 50% in 2007 and 2012.
  
  
  CONCLUSIONS
  Changes in the use of antihypertensive drugs in France between 2002 and 2012 led to the prescription of antihypertensive treatment with associations in the majority. ARBs or ACEI are present on 70% of prescriptions with diuretics combined in 80%. Extensive use of fixed-dose combinations with diuretics and ARA2 characterizes this period in which it was observed an increase in blood pressure control in France.
authors.affiliation: Comité français de lutte contre l'hypertension artérielle (CFLHTA), 5, rue des Colonnes-Du-Trône, 75012 Paris, France. Xavier.girerd@psl.aphp.fr
authors.forename: X
authors.initials: X
authors.lastname: Girerd
authors.forename: O
authors.initials: O
authors.lastname: Hanon
authors.forename: B
authors.initials: B
authors.lastname: Pannier
authors.forename: B
authors.initials: B
authors.lastname: Vaïsse
authors.forename: J-J
authors.initials: JJ
authors.lastname: Mourad
mesh_terms: D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D018660:Blood Pressure Monitoring, Ambulatory / Q000639:trends; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000639:trends; D005260:Female; D005602:France; D019538:Health Care Surveys; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012494:Sampling Studies; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000318:Adrenergic beta-Agonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004232:Diuretics
keywords: Antihypertensive drugs; Arterial hypertension; Combinaison fixe d’antihypertenseur; Enquête FLAHS; FLAHS survey; Fixed-dose combination; Hypertension artérielle; Traitements antihypertenseurs