title: Microwave-assisted synthesis and biological evaluation of some benzimidazole derivatives containing a 1,2,4-triazol ring.
abstract: A new series of 2-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole derivatives containing a 1,2,4-triazole ring were synthesized via microwave technique. This efficient procedure provides pure products within a few minutes. The newly synthesized compounds were confirmed by (1) H NMR and (13) C NMR spectra and they were screened for their lipase inhibition and antioxidant activities. Compounds 4a, 4b, 5a, and 5b showed very good scavenging activity.
authors.affiliation: Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdoğan University, Rize, Turkey. emre.mentese@erdogan.edu.tr
authors.forename: Emre
authors.initials: E
authors.lastname: Menteşe
authors.forename: Nesrin
authors.initials: N
authors.lastname: Karaali
authors.forename: Fatih
authors.initials: F
authors.lastname: Yilmaz
authors.forename: Serdar
authors.initials: S
authors.lastname: Ulker
authors.forename: Bahittin
authors.initials: B
authors.lastname: Kahveci
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D052160:Benzothiazoles / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology*; D008049:Lipase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D001562:Benzimidazoles; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D010851:Picrates; D013451:Sulfonic Acids; D014230:Triazoles; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C045575:1,2,4-triazole; C004931:1,1-diphenyl-2-picrylhydrazyl; D008049:Lipase
keywords: 1,2,4-Triazole; 2-(4-(Trifluoromethyl)phenyl)-1H-benzo[d]imidazole; Antioxidant activity; Lipase inhibition