title: One-pot synthesis of 3-triazolyl-2-iminochromenes via a catalytic three component cascade reaction.
abstract: A variety of 3-triazolyl-2-iminochromenes were synthesized in a one-pot, catalytic, three component condensation. In this event, a Cu(I)-catalyzed cycloaddition between 2-azidoacetonitrile and an acetylene formed a triazole and activated the neighboring methylene group, inducing an aldol-cyclization-dehydration sequence in the presence of a salicylaldehyde. Further elaboration led to more complex polyheterocycles.
authors.affiliation: Therapeutic Discovery, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States.
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Qian
authors.forename: Albert
authors.initials: A
authors.lastname: Amegadzie
authors.forename: David
authors.initials: D
authors.lastname: Winternheimer
authors.forename: Jennifer
authors.initials: J
authors.lastname: Allen
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D061565:Cycloaddition Reaction; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001578:Benzopyrans; D006571:Heterocyclic Compounds; D009570:Nitriles; D014230:Triazoles; D003300:Copper