title: Perinatally HIV-infected youth presenting with acute stroke: progression/evolution of ischemic disease on neuroimaging.
abstract: OBJECTIVE
  Although HIV infection is decreasing in infants and children, there is a steady cohort of perinatally HIV-infected (PHIV) children that are growing older. Increased risk of acute stroke has been reported in PHIV children. Our goal was to evaluate evolution/progression of neuroimaging findings in PHIV youth initially presenting with acute stroke.
  
  
  METHODS
  The medical records of PHIV pediatric patients (n = 179) from 1996 to 2010 were reviewed and patients with clinical documentation of acute stroke referred to the neuroradiology service were eligible for the study. Neuroimaging (brain CT, MRI, and MRA) and charts were evaluated; clinical and neuroimaging findings at the initial acute stroke and at the last presentation to the neuroradiology service were documented and analyzed.
  
  
  RESULTS
  Eight PHIV patients with clinical findings of acute stroke referred to the neuroimaging were identified. CT and MRI findings of infarction were found in all (8/8) patients in their first and/or last neuroimaging study; including basal ganglia-thalami (BGT) infarction (7/8), focal cortical infarction (4/8), and internal capsule infarction (4/8). Imaging depicted cortical atrophy (5/8), BGT calcification (3/8), and posterior reversible encephalopathy syndrome, wallerian degeneration, and periventricular white matter hyperintense T2 signal each in one patient. No tumors or infectious masses, cysts or abscesses were identified. Subsequent available neuroimaging revealed progression of the cerebrovascular disease in seven patients, 5/7 in the absence of new clinical signs or symptoms. Segmental occlusion, narrowing or narrowing/dilatation in the circle of Willis was found in 6/6 patients who underwent MR angiography and fusiform aneurysms were detected in three of them, a saccular aneurysm in one patient.
  
  
  CONCLUSIONS
  Asymptomatic progression of cerebrovascular disease was found in PHIV adolescents with prior stroke. These findings may have implications for long-term risk and outcomes for this patient population. There should be a low threshold to evaluate for CNS pathology even with minor symptoms in this population. More studies are necessary to determine if there is a benefit from screening of asymptomatic patients.
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD 21287, USA. iizbuda1@jhmi.edu
authors.forename: Izlem
authors.initials: I
authors.lastname: Izbudak
authors.forename: Majid
authors.initials: M
authors.lastname: Chalian
authors.forename: Nancy
authors.initials: N
authors.lastname: Hutton
authors.forename: Visveshwar
authors.initials: V
authors.lastname: Baskaran
authors.forename: Lori
authors.initials: L
authors.lastname: Jordan
authors.forename: George K
authors.initials: GK
authors.lastname: Siberry
authors.forename: Philippe
authors.initials: P
authors.lastname: Gailloud
authors.forename: Allison L
authors.initials: AL
authors.lastname: Agwu
mesh_terms: D000293:Adolescent; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D059906:Neuroimaging / Q000379:methods*; D012189:Retrospective Studies; D020521:Stroke / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D055815:Young Adult
keywords: AIDS; Cerebrovascular accident; HIV; Imaging; Perinatal; Stroke