title: [Subcutaneous teicoplanin for children with infectious endocarditis].
abstract: BACKGROUND
  Infectious endocarditis in children requires prolonged antibiotic therapy. In adults, antibiotics administrated subcutaneously such as teicoplanin are an alternative to intravenous treatment.
  
  
  METHODS
  We report the use of subcutaneous teicoplanin, after an initial antibiotic treatment administrated intravenously, for 2 children treated for infectious endocarditis following an initial cardiac surgery. Serum concentrations of teicoplanin were within the target range after the adaptation in the teicoplanin subcutaneous dosages. The treatment was effective for both cases. No specific side effects related to the treatment were reported.
  
  
  CONCLUSIONS
  Subcutaneous administration could be used for prolonged antibiotic therapy for the treatment of infectious endocarditis in children, after an initial intravenous treatment. Variability of the bioavailability of antibiotics administrated subcutaneously requires regular testing. Prospective, randomized trials comparing intravenous and subcutaneous administration of teicoplanin should be conducted to assess the efficacy and safety of this treatment.
authors.affiliation: Pneumologie allergologie pédiatrique, pôle femme-couple-enfant, CHU d'Amiens, 80054 Amiens cedex 1, France.
authors.forename: E
authors.initials: E
authors.lastname: Carpentier
authors.forename: B
authors.initials: B
authors.lastname: Roméo
authors.forename: Y
authors.initials: Y
authors.lastname: El Samad
authors.forename: L
authors.initials: L
authors.lastname: Geslin-Lichtenberger
authors.forename: Y
authors.initials: Y
authors.lastname: Maingourd
authors.forename: P
authors.initials: P
authors.lastname: Tourneux
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D013290:Streptococcal Infections / Q000188:drug therapy; D017334:Teicoplanin / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D017334:Teicoplanin