title: A brief history of triplet repeat diseases.
abstract: Instability of repetitive DNA sequences within the genome is associated with a number of human diseases. The expansion of trinucleotide repeats is recognized as a major cause of neurological and neuromuscular diseases, and progress in understanding the mutations over the last 20 years has been substantial. Here we provide a brief summary of progress with an emphasis on technical advances at different stages.
authors.affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
authors.forename: Helen
authors.initials: H
authors.lastname: Budworth
authors.forename: Cynthia T
authors.initials: CT
authors.lastname: McMurray
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics*; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000235:genetics / Q000378:metabolism; D018911:Trinucleotide Repeats
chemical_list: D002843:Chromatin; D011506:Proteins; D012313:RNA