title: Delineating the "galectin signature" of the tumor microenvironment.
abstract: Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a dynamically regulated 'galectin signature', which delineates the progression of prostate cancer, highlighting galectin-1 as an attractive target for anti-angiogenic therapy in advanced stages of the disease.
authors.affiliation: Laboratorio de Glicómica Estructural y Funcional; IQUIBICEN-CONICET; Departamento de Química Biológica; Facultad de Ciencias Exactas y Naturales; Universidad de Buenos Aires; Buenos Aires, Argentina.
authors.forename: Daniel
authors.initials: D
authors.lastname: Compagno
authors.forename: Diego J
authors.initials: DJ
authors.lastname: Laderach
authors.forename: Lucas
authors.initials: L
authors.lastname: Gentilini
authors.forename: Felipe M
authors.initials: FM
authors.lastname: Jaworski
authors.forename: Gabriel A
authors.initials: GA
authors.lastname: Rabinovich
keywords: angiogenesis; galectins; gene signature; metastasis; prostate cancer