title: [The blood system and bone marrow during aging. The new method of hemogram assessment: blood analysis along with synthesis].
abstract: This article represents the particularities of people's blood and bone marrow referent parameters during aging. On the basis of 56 blood parameters of apparently healthy people a mathematical model of blood's morphofunctional state during physical aging was created. The following integral changes have been discovered: in age group of 35-59 years the integral indicator amounts to 0.05 +/- 0.0008, it approaches the benchmark in elderly age (0.02 +/- 0.0001) and becomes negative with people of gerontic age (-0.06 +/- 0.0003). On the basis of 14 selected blood parameters a calculation of referent integral indicators of blood state for healthy people of various age groups was performed, which serve as standards in clinical practice. Out of 70 peripheral blood cells' indicators the integral indicators for patients suffering from community-acquired pneumonia were calculated. The organism reacts to pneumonia most appropriately at the age of 22-34 years (integral indicator amounts to -0.0386). In patients of 35-59 years the integral indicator descends closer to zero mark (-0.0236), pointing to minor reaction to inflammation. Patients over 60 years of age show the biggest divergence of integral indicator from the benchmark (-0.0613), which points to an inadequate reaction of the organism to inflammation in this age. Based on discriminant analysis of 80 indicators (clinical blood analysis, cytograms, cardiac beat count, breath count, C-reactive protein) the most informatory indicators used to create the algorithm for determination of pneumonia severity were chosen.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Pimenov
authors.forename: I L
authors.initials: IL
authors.lastname: Davydkin
authors.forename: O I
authors.initials: OI
authors.lastname: Fedorova
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000473:pathology; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D001856:Bone Marrow Examination; D017714:Community-Acquired Infections; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D011014:Pneumonia / Q000097:blood* / Q000473:pathology; D012737:Sex Factors; D055815:Young Adult