title: Stress hyperglycemia in acute ST-segment elevation myocardial infarction is a marker of left ventricular remodeling.
abstract: BACKGROUND
  Stress hyperglycemia (SH) in STEMI is associated with high risk of in-hospital mortality. It is still controversial if SH is marker of high post-hospital risk.
  
  
  OBJECTIVE
  The aim was to analyze in-hospital and one-year risk associated with SH in STEMI and to study if SH is marker of LV remodeling.
  
  
  METHODS
  We enrolled 275 patients who were admitted with first STEMI and reperfused. Patients were divided according to admission glycemia in three groups: (1) with diabetes mellitus (DM); (2) with SH, without DM and; (3) without both DM and SH. SH was defined as admission blood glucose level ≥ 8 mmol/l.
  
  
  RESULTS
  In-hospital mortality was higher in patients with known DM (5%) and highest in patients with SH without previous DM (9.3%), and only 1.6% in the third group, P < 0.05. In patients without known DM, SH was associated with 6.378-fold higher in-hospital mortality. Total mortality was double in group with SH without DM compared to the third group (13.9% versus 6.3%). EDV changed in patients with SH without DM from 126 ± 37 to 145 ± 30 ml after one year, P < 0.05.
  
  
  CONCLUSIONS
  SH is associated with high in-hospital mortality risk and it could be marker of LV remodeling (significant increase of EDV during one year).
authors.affiliation: Clinic for cardiovascular diseases, Clinical Center, Nis, Serbia.
authors.forename: Danijela
authors.initials: D
authors.lastname: Djordjevic-Radojkovic
authors.forename: Goran
authors.initials: G
authors.lastname: Koracevic
authors.forename: Dragana
authors.initials: D
authors.lastname: Stanojevic
authors.forename: Miodrag
authors.initials: M
authors.lastname: Damjanovic
authors.forename: Svetlana
authors.initials: S
authors.lastname: Apostolovic
authors.forename: Milan
authors.initials: M
authors.lastname: Pavlovic
mesh_terms: D000368:Aged; D016757:Death, Sudden, Cardiac; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications; D011379:Prognosis; D013312:Stress, Physiological; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling