title: Dietary Chinese quince polyphenols suppress generation of α-dicarbonyl compounds in diabetic KK-A(y) mice.
abstract: Many dietary polyphenols can provide health benefits, such as antioxidant and antidiabetic effects, and can down-regulate the progression of glycation (one cause of diabetic complications). Chinese quince (CQ) is rich in polyphenols, especially procyanidins. A few studies have indicated that CQ has an effect on diabetes. In this study, a procyanidin-rich extract was prepared from Chinese quince fruit (CQE), and its effects were investigated and compared with those of green tea extract (GTE) in type 2 diabetes model KK-A(y) mice. Mice were provided one of two high-fat (HF) diets for 4 weeks: a HF diet containing 0.5% CQE or a HF diet containing 0.5% GTE. Blood glucose was suppressed in mice fed CQE and GTE during the experimental period (p < 0.05), although the effect of CQE was weaker than that of GTE. Intake of CQE had no effect on the blood insulin level, whereas GTE decreased the insulin level. Body weight gain was suppressed in mice fed CQE similarly to mice fed GTE (p < 0.05). Hepatic lipid content and α-dicarbonyl compounds in the kidney were reduced in mice fed CQE and GTE (p < 0.05). These results suggest that intake of CQE could moderate type 2 diabetes and diabetic complications.
authors.affiliation: Bioresources Science, The United Graduate School of Agricultural Sciences, Iwate University 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Nagahora
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ito
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagasawa
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D005638:Fruit / Q000737:chemistry; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D010936:Plant Extracts / Q000008:administration & dosage*; D059808:Polyphenols / Q000008:administration & dosage*; D027824:Rosaceae / Q000737:chemistry*
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D059808:Polyphenols