title: Antioxidative/acetylcholinesterase inhibitory activity of some Asteraceae plants.
abstract: The extracts obtained by 80% EtOH from some Asteraceae plants (Calendula officinalis, Inula helenium, Arctium lappa, Artemisia absinthium and Achillea millefolium) were studied. Rosmarinic acid, one of the main compounds identified in all extracts, was determined quantitatively by using HPLC. In addition, spectrophotometric methods were evaluated as an alternative for rosmarinic acid content determination. Total phenolic content was also established for all extracts. A. millefolium extract was found to have the highest content of rosmarinic acid as well as total phenols. All extracts were tested for antioxidant and acetylcholinesterase inhibitory activity. A. millefolium was shown to possess the best antioxidant activity (for all tested methods) as well as acetylcholinesterase inhibitory activity. Highly positive linear relationships were obtained between antioxidant/acetylcholinesterase inhibitory activity and the determined rosmarinic acid content indicating its significance for the observed activities.
authors.affiliation: Department of Food Technology and Biotechnology, University of Split, Faculty of Chemistry and Technology, Teslina 10, 21000 Split, Croatia. gene@ktf-split.hr
authors.forename: Ivana Generalić
authors.initials: IG
authors.lastname: Mekinić
authors.forename: Franko
authors.initials: F
authors.lastname: Burcul
authors.forename: Ivica
authors.initials: I
authors.lastname: Blazević
authors.forename: Danijela
authors.initials: D
authors.lastname: Skroza
authors.forename: Daniela
authors.initials: D
authors.lastname: Kerum
authors.forename: Visnja
authors.initials: V
authors.lastname: Katalinić
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D002934:Cinnamates / Q000032:analysis; D053630:Depsides / Q000032:analysis; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D000097123:Rosmarinic Acid
chemical_list: D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D002934:Cinnamates; D053630:Depsides; D010936:Plant Extracts; D000097123:Rosmarinic Acid