title: Do not underestimate nucleotide excision repair: it predicts not only melanoma risk but also survival outcome.
abstract: Nucleotide excision repair (NER) removes UV-induced DNA damage and other bulky DNA lesions, thereby maintaining genomic integrity. Dr Qingyi Wei's group demonstrated over the last decade that NER fidelity and single-nucleotide polymorphisms (SNPs) in NER genes constitute melanoma risk biomarkers. In this issue, Li et al. provide evidence that SNPs in NER genes may also predict melanoma survival.
authors.affiliation: Department of Dermatology, Venerology, and Allergology, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Emmert
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Kraemer
mesh_terms: D004260:DNA Repair / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000401:mortality*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics* / Q000401:mortality*