title: Ischemia modified albumin and plasma oxidative stress markers in Alzheimer's disease.
abstract: OBJECTIVE
  The objective of this study was to determine ischemia modified albumin (IMA) and oxidant status in Alzheimer's disease (AD). Therefore, we evaluated the IMA and oxidant status by measuring serum uric acid, albumin and gamma-glutamyltransferase (GGT) in AD.
  
  
  METHODS
  The plasma albumin, uric acid, GGT and IMA levels were measured by spectrophotometric methods in 32 AD patients and 32 healthy controls. The Mini Mental Status Examination and Clinical Dementia Rating Scale were used to evaluate the cognitive functions of AD patients.
  
  
  RESULTS
  AD patients had significantly higher IMA levels as compared to those of the controls respectively. Uric acid concentrations were significantly decreased and GGT values were significantly increased in AD when compared with control group. Albumin levels of the patients were also compared and no significant difference was detected.
  
  
  CONCLUSIONS
  Oxidative stress and IMA levels rise in AD. However, large prospective studies are required to understand the mechanisms leading to increased IMA levels during AD, whether preceded or not by AD.
authors.affiliation: Department of Biochemistry, Bulent Ecevit University, Faculty of Medicine, Zonguldak, Turkey. drcanmurat@yahoo.com
authors.forename: Murat
authors.initials: M
authors.lastname: Can
authors.forename: Figen
authors.initials: F
authors.lastname: Varlibas
authors.forename: Berrak
authors.initials: B
authors.lastname: Guven
authors.forename: Ozkan
authors.initials: O
authors.lastname: Akhan
authors.forename: Gulbun Asuman
authors.initials: GA
authors.lastname: Yuksel
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D018384:Oxidative Stress / Q000502:physiology*; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D014527:Uric Acid / Q000097:blood*; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D014527:Uric Acid; D005723:gamma-Glutamyltransferase; D000075462:Serum Albumin, Human