title: Repeated renal infarction in native and transplanted kidneys due to left ventricular thrombus formation caused by antiphospholipid antibody syndrome.
abstract: Antiphospholipid syndrome can be a feature of several underlying conditions, such as lupus, but it can also occur idiopathically. Diagnosis usually comes after investigation of recurrent venous or arterial thromboses, emboli, or hypertension/proteinuria where the kidney is involved and is usually confirmed by laboratory testing. We describe a case of a man with a myocardial infarction who developed mural thrombus in an akinetic left ventricular segment but then who recurrently embolized first to one of his native kidneys and then later to a transplanted kidney. Although the clinical behavior was typical of antiphospholipid syndrome, it took numerous laboratory assays over many years until finally the problem was confirmed and life-long warfarin therapy instituted.
authors.affiliation: Nephrology Department, King's Health Partners, Academic Health Sciences Centre, London, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: Scully
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Leckstroem
authors.forename: Andrew
authors.initials: A
authors.lastname: McGrath
authors.forename: John
authors.initials: J
authors.lastname: Chambers
authors.forename: David J
authors.initials: DJ
authors.lastname: Goldsmith
keywords: antiphospholipid therapy; emboli; infarction; kidney; kidney transplant