title: Zoonotic Mycobacterium bovis-induced tuberculosis in humans.
abstract: We aimed to estimate the global occurrence of zoonotic tuberculosis (TB) caused by Mycobacterium bovis or M. caprae infections in humans by performing a multilingual, systematic review and analysis of relevant scientific literature of the last 2 decades. Although information from many parts of the world was not available, data from 61 countries suggested a low global disease incidence. In regions outside Africa included in this study, overall median proportions of zoonotic TB of ≤1.4% in connection with overall TB incidence rates ≤71/100,000 population/year suggested low incidence rates. For countries of Africa included in the study, we multiplied the observed median proportion of zoonotic TB cases of 2.8% with the continental average overall TB incidence rate of 264/100,000 population/year, which resulted in a crude estimate of 7 zoonotic TB cases/100,000 population/year. These generally low incidence rates notwithstanding, available data indicated substantial consequences of this disease for some population groups and settings.
authors.affiliation: Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa. borna.mueller@gmail.com
authors.forename: Borna
authors.initials: B
authors.lastname: Müller
authors.forename: Salome
authors.initials: S
authors.lastname: Dürr
authors.forename: Silvia
authors.initials: S
authors.lastname: Alonso
authors.forename: Jan
authors.initials: J
authors.lastname: Hattendorf
authors.forename: Cláudio J M
authors.initials: CJ
authors.lastname: Laisse
authors.forename: Sven D C
authors.initials: SD
authors.lastname: Parsons
authors.forename: Paul D
authors.initials: PD
authors.lastname: van Helden
authors.forename: Jakob
authors.initials: J
authors.lastname: Zinsstag
mesh_terms: D000349:Africa; D000569:Americas; D000818:Animals; D001315:Australia; D002417:Cattle; D002681:China; D060085:Coinfection; D005060:Europe; D015658:HIV Infections / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D009163:Mycobacterium bovis; D009520:New Zealand; D014376:Tuberculosis / Q000453:epidemiology*; D015047:Zoonoses / Q000453:epidemiology*
keywords: Mycobacterium bovis; TB; bacteria; bovine tuberculosis; neglected tropical diseases; systematic review; tuberculosis and other mycobateria; zoonosis; zoonotic TB