title: From integrative genomics to therapeutic targets.
abstract: Combinatorial approaches that integrate conventional pathology with genomic profiling and functional genomics have begun to enhance our understanding of the genetic basis of breast cancer. These methods have identified key genotypic-phenotypic correlations in different breast cancer subtypes that have led to the discovery of genetic dependencies that drive their behavior. Moreover, this knowledge has been applied to define novel tailored therapies for these groups of patients with cancer. With the current emphasis on characterizing the mutational repertoire of breast cancers by next-generation sequencing, the question remains as to what constitutes a driver event. By focusing efforts on homogenous subgroups of breast cancer and integrating orthogonal data-types combined with functional approaches, we can begin to unravel the heterogeneity and identify aberrations that can be therapeutically targeted.
authors.affiliation: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom. rachael.natrajan@icr.ac.uk
authors.forename: Rachael
authors.initials: R
authors.lastname: Natrajan
authors.forename: Paul
authors.initials: P
authors.lastname: Wilkerson
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic; D056726:Genetic Association Studies / Q000379:methods / Q000639:trends; D023281:Genomics / Q000379:methods*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends; D057170:Translational Research, Biomedical / Q000379:methods / Q000639:trends