title: Biotemplated syntheses of macroporous materials for bone tissue engineering scaffolds and experiments in vitro and vivo.
abstract: The macroporous materials were prepared from the transformation of cuttlebone as biotemplates under hydrothermal reactions and characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric/differential thermal analyses (TG-DTA), and scanning electron microscopy (SEM). Cell experimental results showed that the prepared materials as bone tissue engineering scaffolds or fillers had fine biocompatibility suitable for adhesion and proliferation of the hMSCs (human marrow mesenchymal stem cells). Histological analyses were carried out by implanting the scaffolds into a rabbit femur, where the bioresorption, degradation, and biological activity of the scaffolds were observed in the animal body. The prepared scaffolds kept the original three-dimensional frameworks with the ordered porous structures, which made for blood circulation, nutrition supply, and the cells implantation. The biotemplated syntheses could provide a new effective approach to prepare the bone tissue engineering scaffold materials.
authors.affiliation: Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, PR China. lixing@nbu.edu.cn
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.forename: Yayun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yue
authors.initials: Y
authors.lastname: Bing
authors.forename: Yaping
authors.initials: Y
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Gan
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Guo
authors.forename: Zhaoxiang
authors.initials: Z
authors.lastname: Peng
authors.forename: Yabin
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D060105:Animal Shells; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D001696:Biomechanical Phenomena; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D049832:Decapodiformes; D005269:Femur / Q000166:cytology*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology; D011817:Rabbits; D013818:Thermogravimetry; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials