title: Intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide.
abstract: This study focused on the intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide (MTS). The nanocarriers showed an efficient cellular uptake, and the MTS had a positive effect on their mitochondrial targeting. This is the first report of an intracellular observation of nanocarriers modified with MTS.
authors.affiliation: Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Kawamura
authors.forename: Yuma
authors.initials: Y
authors.lastname: Yamada
authors.forename: Yukari
authors.initials: Y
authors.lastname: Yasuzaki
authors.forename: Mamoru
authors.initials: M
authors.lastname: Hyodo
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Harashima
mesh_terms: D004337:Drug Carriers / Q000032:analysis / Q000378:metabolism; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D050997:Nanomedicine; D049329:Nanostructures / Q000032:analysis* / Q000737:chemistry; D021382:Protein Sorting Signals; D013379:Substrate Specificity
chemical_list: D004337:Drug Carriers; D021382:Protein Sorting Signals
keywords: MITO-Porter; Mitochondria; Mitochondrial drug delivery; Mitochondrial targeting signal peptide (MTS); Nanocarriers; Nanotechnology