title: Papillary thyroid carcinoma: bilateral choroidal metastases with extrascleral extension.
abstract: Here, we present the case of a patient with bilateral choroidal metastases with extraocular extension in one eye. Metastasis of papillary thyroid carcinoma to the uvea is extremely rare, with only 6 patients reported in the literature. A 62-year-old man with a prior history of papillary thyroid carcinoma suffered the rapid loss of vision in his right eye. He had neovascular glaucoma, total retinal detachment, and a solitary choroidal mass. A month later, his left visual acuity also decreased because of a small macular choroidal mass. The right eye was enucleated and a nodular lesion over the sclera representing extraocular extension was observed. This tumor and the intraocular lesion were composed of papillary excrescences and cystic spaces and stained positively for thyroid transcription factor 1 and thyroglobulin, all confirming the diagnosis of metastatic papillary thyroid carcinoma. The tumor in the left eye was successfully treated with diode laser transpupillary thermotherapy. The patient expired within a month as a result of widespread pulmonary metastases. Papillary thyroid carcinoma may metastasize to the uvea bilaterally, cause rapid visual function loss, erode the sclera, and may extend outside the globe similar to choroidal melanoma. This aggressive ocular involvement was associated with a dismal prognosis in our patient.
authors.affiliation: Ocular Oncology Service, Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey. hkiratli@hacettepe.edu.tr
authors.forename: Hayyam
authors.initials: H
authors.lastname: Kiratli
authors.forename: Berçin
authors.initials: B
authors.lastname: Tarlan
authors.forename: Figen
authors.initials: F
authors.lastname: Söylemezoğlu
mesh_terms: D002277:Carcinoma / Q000473:pathology* / Q000628:therapy; D002291:Carcinoma, Papillary; D002829:Choroid / Q000473:pathology*; D002830:Choroid Neoplasms / Q000556:secondary* / Q000628:therapy; D006801:Humans; D006979:Hyperthermia, Induced; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012590:Sclera / Q000473:pathology*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000628:therapy
keywords: Choroid; Neoplasm metastasis; Papillary carcinoma; Thyroid gland; Transpupillary thermotherapy