title: The use of a polycaprolactone-tricalcium phosphate scaffold for bone regeneration of tooth socket facial wall defects and simultaneous immediate dental implant placement in Macaca fascicularis.
abstract: Bone regeneration and aesthetic outcomes may be compromised when immediate implants are placed at extraction sites with dehiscence defects. The aim of this study was to compare, in a monkey model, peri-implant bone regeneration and implant stability after immediate implant placement into tooth sockets with facial wall defects in two treatment groups. In eight control monkeys, the bony defect was reconstructed with autogenous particulate bone, whereas in 10 test monkeys a polycaprolactone-tricalcium phosphate (PCL-TCP) scaffold was used. The monkeys were sacrificed after 6 months and the specimens were analyzed by histology and histomorphometry. Better maintenance of facial bone contour was noted in the test group; however, bone regeneration was seen only at areas adjacent to a bony wall of the defect. The mean bone-to-implant contact was 27.6 ± 19.1% (control group) versus 6.8 ± 7.9% (test group). The mean bone area percentage was 11.8 ± 10.1% (control group) versus 6.8 ± 6.9% (test group). Implant survival was 100% at 6 months for both the groups. It was concluded that although the use of a PCL-TCP scaffold showed better maintenance of the alveolar contour as compared to autogenous particulate bone at 6 months, there was minimal bone regeneration within the defect.
authors.affiliation: Department of Oral & Maxillofacial Surgery, National Dental Centre Singapore, Singapore, Singapore.
authors.forename: Bee Tin
authors.initials: BT
authors.lastname: Goh
authors.forename: Nattharee
authors.initials: N
authors.lastname: Chanchareonsook
authors.forename: Henk
authors.initials: H
authors.lastname: Tideman
authors.forename: Swee Hin
authors.initials: SH
authors.lastname: Teoh
authors.forename: James Kwok Fai
authors.initials: JK
authors.lastname: Chow
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
mesh_terms: D000539:Alveolar Process / Q000187:drug effects / Q000473:pathology; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D002130:Calcium Phosphates / Q000494:pharmacology*; D015921:Dental Implants; D008252:Macaca fascicularis; D008297:Male; D008437:Maxilla / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D011091:Polyesters / Q000494:pharmacology*; D011859:Radiography; D054457:Tissue Scaffolds / Q000737:chemistry*; D020390:Tooth Socket / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology*
chemical_list: D002130:Calcium Phosphates; D015921:Dental Implants; D011091:Polyesters; C016240:polycaprolactone; C018392:tricalcium phosphate
keywords: bioresorbable; bone regeneration; dehiscence defects; immediate implants; polycaprolactone-tricalcium phosphate scaffold