title: Synthesis of a novel benzodifuran derivative and its molecular recognition of poly rA RNA.
abstract: In this manuscript, we describe a synthetic approach to a novel benzodifuran derivative as well as CD studies regarding its ability to interact with DNA and RNA. After the chemical synthesis and ESI-MS and NMR characterization, this heteroaromatic molecule was investigated by CD spectroscopy in order to evaluate it as a potential nucleic acid binder. Interestingly, the benzodifuran compound was found to be able to induce conformational changes in both DNA and RNA homoadenine molecules forming in the latter case a complex with a 6:1 benzodifuran/nucleobase stoichiometric ratio, as evidenced by CD titration experiments.
authors.affiliation: Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, I-80134 Napoli, Italy. giovanni.roviello@cnr.it
authors.forename: Giovanni N
authors.initials: GN
authors.lastname: Roviello
authors.forename: Valentina
authors.initials: V
authors.lastname: Roviello
authors.forename: Domenica
authors.initials: D
authors.lastname: Musumeci
authors.forename: Carlo
authors.initials: C
authors.lastname: Pedone
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011061:Poly A / Q000138:chemical synthesis* / Q000737:chemistry / Q000235:genetics; D012313:RNA / Q000737:chemistry* / Q000235:genetics
chemical_list: D001572:Benzofurans; D011061:Poly A; D012313:RNA