title: Study on the effect of kidney transplantation on the health of the patients' offspring: a report on 252 Chinese children.
abstract: Even though the incidence of pregnancies in the female recipients is lower and also chronic renal disease in male patients is associated with impaired spermatogenesis, the health of the children born to these patients was not studied. In this report, we discuss information on the growth and development of offspring of 248 male and female kidney recipient patients. Physical and routine clinical measurements of the 252 offspring (129 male and 123 female) born to these transplantation patients were made along with the intelligence tests. In some of these children chest X-ray and immune indices were assessed. Among the recipients, 219 males fathered 223 children with an average birth weight of 3,255 ± 374 g and 29 female recipients gave birth to 29 children with an average birth weight of 2,923 ± 551. While most of these children were normal, we noticed a case of soft double toe, a case of short tongue tie, five cases of marginal mental retardation, three cases of proteinuria, six cases of microscopic hematuria, 15 cases of low hemoglobin, and 21 cases with recurrent respiratory tract infections. We conclude that kidney transplantation has no significant impact on the growth, development, health, and intelligence of the offspring born to recipients.
authors.affiliation: Kidney Transplant Center, Jiulisong Hospital, Hangzhou, 310013, China, xulonggen88@sina.com.
authors.forename: Longgen
authors.initials: L
authors.lastname: Xu
authors.forename: Peng
authors.initials: P
authors.lastname: Han
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
authors.forename: Yirong
authors.initials: Y
authors.lastname: Yang
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
authors.forename: Wanling
authors.initials: W
authors.lastname: Peng
authors.forename: Ligong
authors.initials: L
authors.lastname: Tang
authors.forename: Jing
authors.initials: J
authors.lastname: Fu
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Zhu
authors.forename: Youhua
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000328:Adult; D001724:Birth Weight; D002648:Child; D002675:Child, Preschool; D002681:China; D003404:Creatinine / Q000097:blood; D004906:Erythrocyte Count; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007166:Immunosuppressive Agents / Q000097:blood / Q000627:therapeutic use; D007223:Infant; D007231:Infant, Newborn; D007360:Intelligence; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012042:Registries
chemical_list: D006454:Hemoglobins; D007136:Immunoglobulins; D007166:Immunosuppressive Agents; D003404:Creatinine