title: Lineage-dependent circuit assembly in the neocortex.
abstract: The neocortex plays a key role in higher-order brain functions, such as perception, language and decision-making. Since the groundbreaking work of Ramón y Cajal over a century ago, defining the neural circuits underlying brain functions has been a field of intense study. Here, we review recent findings on the formation of neocortical circuits, which have taken advantage of improvements to mouse genetics and circuit-mapping tools. These findings are beginning to reveal how individual components of circuits are generated and assembled during development, and how early developmental processes, such as neurogenesis and neuronal migration, guide precise circuit assembly.
authors.affiliation: Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Gao
authors.forename: Khadeejah T
authors.initials: KT
authors.lastname: Sultan
authors.forename: Xin-Jun
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Song-Hai
authors.initials: SH
authors.lastname: Shi
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000235:genetics / Q000502:physiology; D006801:Humans; D019579:Neocortex / Q000166:cytology* / Q000378:metabolism; D055495:Neurogenesis / Q000235:genetics / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000378:metabolism
keywords: Lineage; Neocortex; Neuronal circuits