title: No association between AKT1 gene variants and schizophrenia: a Malaysian case-control study and meta-analysis.
abstract: We aim to replicate AKT1 gene variants studies using Malaysian samples. Seven AKT1 single nucleotide polymorphisms (SNPs) were studied in 417 patients and 429 controls. Haplotype showed significant association (p=0.036) with schizophrenia, especially in Malays and Indians. Meta-analysis of rs2494732 showed significant association worldwide (p=0.018) and in Asians (p=0.023).
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering and Science (FES), Universiti Tunku Abdul Rahman (UTAR), Jalan Genting Kelang, Setapak, 53300 Kuala Lumpur, Malaysia; High Impact Research Office, Level 9, Chancellery Building, University of Malaya (UM), 50603 Kuala Lumpur, Malaysia. Electronic address: hcloh@utar.edu.my.
authors.forename: Han Chern
authors.initials: HC
authors.lastname: Loh
authors.forename: Tze Jen
authors.initials: TJ
authors.lastname: Chow
authors.forename: Pek Yee
authors.initials: PY
authors.lastname: Tang
authors.forename: Hoi Sen
authors.initials: HS
authors.lastname: Yong
mesh_terms: D000328:Adult; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008296:Malaysia / Q000453:epidemiology / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics*; D012016:Reference Values; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D055815:Young Adult
chemical_list: C494918:AKT1 protein, human; D051057:Proto-Oncogene Proteins c-akt
keywords: Ethnic analysis; Haplotype; rs2494732