title: TNFα cleavage beyond TACE/ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis.
authors.affiliation: Biochemical Institute, Christian-Albrechts-University Kiel, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Becker-Pauly
authors.forename: Stefan
authors.initials: S
authors.lastname: Rose-John
mesh_terms: D051722:ADAM Proteins / Q000276:immunology* / Q000378:metabolism; D000072198:ADAM17 Protein; D000818:Animals; D003092:Colitis / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D053509:Matrix Metalloproteinase 13 / Q000276:immunology* / Q000378:metabolism; D058990:Molecular Targeted Therapy; D059748:Proteolysis; D018805:Sepsis / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology* / Q000378:metabolism
chemical_list: D014409:Tumor Necrosis Factor-alpha; D051722:ADAM Proteins; D053509:Matrix Metalloproteinase 13; D000072198:ADAM17 Protein; C000606462:ADAM17 protein, human
keywords: ADAM protease; MMP13; inflammatory bowel disease; protease web; sepsis