title: [Association of P53 gene polymorphisms with susceptibility to endometriosis].
abstract: OBJECTIVE
  To assess the association of a single nucleotide polymorphism(SNP) in tumor suppressor gene P53 with the risk of endometriosis (EM) in Han Chinese women.
  
  
  METHODS
  For 460 EM patients, 113 patients with endometrial carcinoma and 530 matched unrelated controls, a rs1042522(C/G) SNP of the P53 gene was genotyped by polymerase chain reaction-single strand polymorphism (PCR-SSP) and DNA sequencing.
  
  
  RESULTS
  A significant difference has been detected in the distribution of rs1042522 alleles and genotypes between the EM patients and controls (P< 0.01). Allele G has increased the risk of EM by 1.209 times, while allele C has reduced this risk by 0.837 times. Compared with GG genotype, GC and CC genotypes have both increased the risk for EM (OR=2.073, 95%CI: 1.521-2.820, and OR=1.930, 95%CI: 1.363-2.733, respectively). Significant differences were also detected in the distribution of rs1042522 alleles and genotypes between endometrial carcinoma patients and controls (P< 0.01). Allele G has increased the risk to endometrial carcinoma by 1.311 times, while allele C has reduced this risk by 0.757 times. Compared with GG genotypes, individuals with GC and CC genotypes are more likely to be affected with endometrial carcinoma (OR=2.778, 95%CI: 1.585-4.870, and OR=2.864, 95%CI: 1.557-5.263, respectively).
  
  
  CONCLUSIONS
  Our study has suggested a significant association between the rs1042522(G/C) polymorphism and susceptibility to EM in Han Chinese women. The mechanism of EM is similar to carcinoma from genetics point of view.
authors.affiliation: Department of Gynecology and Obstetrics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Huang
authors.forename: Lili
authors.initials: L
authors.lastname: Zong
authors.forename: Jianghai
authors.initials: J
authors.lastname: Lin
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Fu
authors.forename: Zehuan
authors.initials: Z
authors.lastname: Liu
authors.forename: Ting
authors.initials: T
authors.lastname: Mao
authors.forename: Jun
authors.initials: J
authors.lastname: Zeng
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000483:Alleles; D044466:Asian People; D001483:Base Sequence; D002681:China; D016889:Endometrial Neoplasms / Q000235:genetics; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53