title: Convergent synthesis and cytotoxic activities of 26-thio- and selenodioscin.
abstract: Convergent block syntheses of 26-thio- and selenodioscin have been achieved by developing the highly stereoselective 1,2-trans glycosylations of chacotriosyl imidate without recourse to neighboring group assistance. Both thiodioscin and selenodioscin possess cytotoxic activities similar to dioscin, a natural spirostanol glycoside.
authors.affiliation: Key Laboratory of Marine Medicine, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003 Shandong, China.
authors.forename: Pengwei
authors.initials: P
authors.lastname: Chen
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Ni
authors.initials: N
authors.lastname: Song
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D004144:Diosgenin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006031:Glycosylation; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D013237:Stereoisomerism
chemical_list: C586242:26-selenodioscin; C586243:26-thiodioscin; D000970:Antineoplastic Agents; D004144:Diosgenin
keywords: Antitumor saponins; Chacotriosyl imidate; Convergent synthesis; Selenodioscin; Stereoselective glycosylation; Thiodioscin