title: Near-infrared femtosecond laser-triggered nanoperforation of hollow microcapsules.
abstract: Fabrication of a nanopore in a hollow microcapsule was demonstrated using near-infrared femtosecond laser irradiation. The shape of the irradiated microcapsules was kept spherical except for a pore in the shell owing to the nonthermal processing by a femtosecond laser. The simulation results for the near-field and far-field scattering around a microcapsule revealed that highly-enhanced optical intensity can be generated at a spot on the shell of a microcapsule, which would in turn contribute to localized ablation. To the best of our knowledge, this is the first demonstration of the nanoperforation of transparent hollow microcapsules by a near-infrared laser without any doping with absorbing metals or dyes that may cause cell toxicity. The presented method is a promising approach for safer drug delivery and the controlled release of therapeutic drugs.
authors.affiliation: Department of Electronics and Electrical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan. terakawa@elec.keio.ac.jp
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Terakawa
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Mitsuhashi
authors.forename: Takuya
authors.initials: T
authors.lastname: Shinohara
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shimizu
mesh_terms: D002214:Capsules / Q000737:chemistry* / Q000528:radiation effects*; D007259:Infrared Rays; D007834:Lasers; D008422:Materials Testing; D058608:Nanopores / Q000648:ultrastructure*; D016062:Porosity / Q000528:radiation effects
chemical_list: D002214:Capsules