title: The serum pentraxin-3 is elevated in patients with cardiac syndrome X.
abstract: OBJECTIVE
  Cardiac syndrome X (CSX) is a clinical entity that is defined as normal coronary arteries with angina pectoris and objective sins of ischemia. The correlation between CSX and inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) is well established, however an association with pentraxin-3 (PTX-3) has not been examined. The aim of this study was to investigate the association between PTX-3 and CSX.
  
  
  METHODS
  A total of 122 patients (58 female, 64 male, mean age 49.6±5.8 years) with suspected of coronary artery disease (CAD) were included in the study. Those with evidence of ischemia (50 patients with positive treadmill tests, 32 patients with positive myocardial perfusion scintography) underwent coronary angiography (82 patients). Patients with a normal angiogram were considered the CSX group (n=41) and patients with coronary lesions were referred to as the CAD group (n=41). Patients without signs of ischemia served as the control group. Serum PTX-3 and hs-CRP levels were measured in all patients.
  
  
  RESULTS
  The CSX group had significantly increased PTX-3 levels relative to the control group (0.46±0.16 vs. 0.23±0.09 ng/ml, p<0.001). However there were no differences in levels of PTX-3 and hs-CRP between the CSX and the CAD groups (PTX-3: 0.46±0.16 vs. 0.51±0.13 ng/ml, p=0.21; hs-CRP: 1.04±0.45 vs. 1.16±0.64 mg/dl, p=0.62). The control group had significantly lower hs-CRP levels (0.73±0.51 mg/dl) when compared to the both CSX and CAD groups (p=0.03 and p=0.002, respectively). Serum PTX-3 levels were weakly correlated with hs-CRP levels (r=0.30, p=0.001).
  
  
  CONCLUSIONS
  PTX-3, a novel inflammatory marker, is elevated in patients with CSX, similar to the well known inflammatory marker hs-CRP, and may be a promising biomarker reflecting inflammatory status in these patients.
authors.affiliation: Department of Cardiology, Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Hatay, Turkey. dreyupbuyukkaya@hotmail.com
authors.forename: Eyüp
authors.initials: E
authors.lastname: Büyükkaya
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Karakaş
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kurt
authors.forename: Sedat
authors.initials: S
authors.lastname: Motor
authors.forename: Adnan Burak
authors.initials: AB
authors.lastname: Akçay
authors.forename: Sule
authors.initials: S
authors.lastname: Büyükkaya
authors.forename: Esra
authors.initials: E
authors.lastname: Karakaş
authors.forename: Nihat
authors.initials: N
authors.lastname: Sen
mesh_terms: D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins