title: MicroRNAs in cardiovascular therapeutics.
abstract: Recent research reveals the crucial role microRNAs (miRNAs) in the pathogenesis and progression of many pathological conditions, including cardiovascular diseases. It is widely documented that miRNAs represent critical regulators of cardiovascular function and participate in almost all aspects of cardiovascular biology. In particular, they are involved in several pathophysiological pathways of various manifestations of cardiovascular disease, such as coronary artery disease, heart failure, stroke, diabetes mellitus, arterial hypertension and cardiac arrhythmias. In the present article we review the available literature regarding to the role of miRNAs in certain cardiovascular conditions. Moreover, we discuss the therapeutic potential of miRNAs for treating cardiovascular diseases and we attempt to highlight future directions.
authors.affiliation: 1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece. gsiasos@med.uoa.gr
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Siasos
authors.forename: Dimitris
authors.initials: D
authors.lastname: Tousoulis
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Tourikis
authors.forename: Savas
authors.initials: S
authors.lastname: Mazaris
authors.forename: Giorgos
authors.initials: G
authors.lastname: Zakynthinos
authors.forename: Evangelos
authors.initials: E
authors.lastname: Oikonomou
authors.forename: Eleni
authors.initials: E
authors.lastname: Kokkou
authors.forename: Christina
authors.initials: C
authors.lastname: Kollia
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*
chemical_list: D035683:MicroRNAs