title: [Study on the status of HBV infection and its determinants among family members with HBV infected persons in Shanghai].
abstract: OBJECTIVE
  To understand the status of HBV infection among family members with HBV infected persons in Shanghai and to probe the determinants of HBV infection so as to provide evidence for improving the related strategies on hepatitis B prevention and control.
  
  
  METHODS
  Three hundred and four hepatitis B patients together with 288 HBsAg carriers from 6 districts in Shanghai were randomly sampled in 2010. All the said persons and their families members were asked to fill in questionnaires and to be drawn 5 ml venous blood for HBV serologic indicators detection. The subjects were divided into case group and control group according to their status of HBV infection. Univariate analysis and multivariate logistic regression analysis were carried out to identify the determinants of HBV infection among family members.
  
  
  RESULTS
  Among 1485 subjects from 592 households, a total of 1137 persons were infected by HBV, with the overall infection rate as 76.57%. Fifteen infection modes were noticed, in which double positive of anti-HBs and anti-HBc, triple positive of HBsAg, anti-HBe and anti-HBc, together with triple positive of anti-HBs, anti-HBe and anti-HBc accounted for the top three, with the proportions as 30.69%, 26.65% and 10.03% respectively. The differences between the years of carrying HBV and the proportions of numbers that carrying HBV in families, were not statistically significant. The infection rate among children (42.86%) was significantly lower than that of their parents (87.54%) (P < 0.001). Results from both univariate and multivariate analysis showed that gender, age, utensil sharing, histories of receiving hepatitis B vaccines and dental outpatient service were determinants of HBV infection among families members (P < 0.05), with OR values being 9.009 for persons without immunization history of hepatitis B vaccines, 3.817 for persons above 40 years old and 2.283 for persons of 21 - 40 years old, 2.222 for families members who sharing utensil, 2.124 for persons with history of dental outpatient service and 1.339 for male members, respectively.
  
  
  CONCLUSIONS
  Family clustering of HBV infection in was seen in Shanghai. In order to reduce the number of HBV infection in families, hepatitis B vaccination program need to be carried out. Healthy lifestyle should be emphasized to prevent HBV infection due to close contact. The risk of iatrogenic HBV transmission should also be prevented.
authors.affiliation: Department of Acute Infectious Disease, Shanghai Municipal Center for Disease Control and Prevention, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Jing-yi
authors.initials: JY
authors.lastname: Liu
authors.forename: Jia-yu
authors.initials: JY
authors.lastname: Hu
authors.forename: Yan-ting
authors.initials: YT
authors.lastname: Li
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005190:Family; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged