title: Protective effect of homonojirimycin from Commelina communis (dayflower) on influenza virus infection in mice.
abstract: The effects of homonojirimycin (HNJ), one of alkaloids from Commelina communis L., on protection against influenza virus infection in mice were investigated. HNJ was found to improve the survival rate, prolong the mean survival time and reduce virus yields in lungs on days 4 and 6 post-infection (p.i.), after the agent had been orally administered to the mice from 2 days before infection to 6 days p.i. Administration of HNJ (1 mg/kg) significantly increased interferon (IFN)-γ and interleukin (IL)-10 levels but decreased tumor necrosis factor (TNF)-α and IL-6 levels in serum and lungs of influenza-infected mice on days 2, 4 or 6 p.i. These results showed that HNJ exerted protection against influenza virus infection and produced effective immune responses in vivo.
authors.affiliation: Pharmacy College, He'nan University of Traditional Chinese Medicine, Zhengzhou 450008, China.
authors.forename: Guo-bin
authors.initials: GB
authors.lastname: Zhang
authors.forename: Lian-qi
authors.initials: LQ
authors.lastname: Tian
authors.forename: Yi-ming
authors.initials: YM
authors.lastname: Li
authors.forename: Yi-fan
authors.initials: YF
authors.lastname: Liao
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Fei-hong
authors.initials: FH
authors.lastname: Bing
mesh_terms: D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D034822:Commelina / Q000737:chemistry*; D016207:Cytokines / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D005260:Female; D009980:Influenza A virus / Q000187:drug effects*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000378:metabolism / Q000821:virology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D016207:Cytokines; D010936:Plant Extracts; C106502:homonojirimycin; D017485:1-Deoxynojirimycin
keywords: A/PR/8/34; C. communis L.; Commelina communis L.; Cytokine; HNJ; Homonojirimycin; IL; INF; Influenza virus; MDCK; Madin–Darby canine kidney; PBS; PR8; TNF; homonojirimycin; interferon; interleukin; phosphate-buffered saline; tumor necrosis factor