title: Treatment failure in automated peritoneal dialysis and double-bag continuous ambulatory peritoneal dialysis.
abstract: OBJECTIVE
  Automated peritoneal dialysis (APD) and double-bag continuous ambulatory peritoneal dialysis (CAPD) are the two current standard modalities of peritoneal dialysis (PD). Outcomes of these two modalities have not been well described.
  
  
  METHODS
  A single-centre, retrospective review was carried out to compare the treatment failure rate of APD and double-bag CAPD. Treatment failure was a combined endpoint including death and technique failure. Cox regression was used to compare risk (hazard ratio, HR) of treatment failure in APD and CAPD.
  
  
  RESULTS
  There were 121 patients included in this study, 55 with APD and 66 with CAPD. APD patients had significantly lower risk of treatment failure (death and technique failure) than CAPD patients (HR 0.58, 95% confidence interval [CI]: 0.37-0.91, P=0.02). The lower risk of treatment failure in APD compared to CAPD was mainly caused by the significantly lower risk of technique failure (HR 0.30, 95%CI: 0.10-0.93, P=0.04). The mortality rates of the two modalities were not significantly different (HR 0.69, 95%CI: 0.42-1.12, P=0.13).
  
  
  CONCLUSIONS
  Our data suggest that APD may have lower risk of treatment failure compared with double-bag CAPD. These potential benefits of APD might justify the use of this modality despite its higher cost.
authors.affiliation: Division of Nephrology, Department of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. pkatavetin@gmail.com
authors.forename: Pisut
authors.initials: P
authors.lastname: Katavetin
authors.forename: Yuwadee
authors.initials: Y
authors.lastname: Theerasin
authors.forename: Worapot
authors.initials: W
authors.lastname: Treamtrakanpon
authors.forename: Nalinee
authors.initials: N
authors.lastname: Saiprasertkit
authors.forename: Talerngsak
authors.initials: T
authors.lastname: Kanjanabuch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001331:Automation; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007674:Kidney Diseases / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018579:Patient Selection; D010530:Peritoneal Dialysis / Q000009:adverse effects* / Q000401:mortality; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects* / Q000401:mortality; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013785:Thailand; D017211:Treatment Failure
keywords: automated peritoneal dialysis; continuous ambulatory peritoneal dialysis; mortality; peritoneal dialysis; treatment failure