title: Long-term survival in patients included in a randomized controlled trial of TREAT, a decision support system for antibiotic treatment.
abstract: OBJECTIVE
  TREAT is a computerized decision support system for antibiotic treatment. In a randomized controlled trial it improved significantly the percentage of appropriate empirical antibiotic treatment and shortened hospital stay, while the usage of broad-spectrum antibiotics was reduced. The trial was not powered to show significance for the difference in 1 month mortality rate. In the present analysis we looked at 6 month survival in one of the hospitals (Beilinson Hospital) that participated in the trial.
  
  
  METHODS
  We plotted the Kaplan-Meier survival function for all patients [intention to treat (ITT)] and for patients treated according to the TREAT advice [per protocol (PP)]. The analysis was repeated for patients with clinically or bacteriologically documented bacterial infections.
  
  
  RESULTS
  At Beilinson Hospital 1683 patients were included in the study, 860 in the intervention arm and 823 in the control arm. In the ITT analysis 180 day survival in control patients was 71% versus 74% in the intervention patients (P = 0.2). In the PP analysis the survival percentages were 71% and 77%, respectively (P = 0.04). In patients with bacterial infections, in the ITT analysis 180 day survival in the control group was 68% versus 71% in the intervention patients (P = 0.1). In the PP analysis the survival percentages were 68% versus 74% (P = 0.04).
  
  
  CONCLUSIONS
  The present data support an effect of the TREAT decision support system on 6 month survival, mainly because of its benefit in patients with documented bacterial infections.
authors.affiliation: Department of Medicine E, Beilinson Hospital, Rabin Medical Center, Petah-Tiqva, Israel.
authors.forename: Leonard
authors.initials: L
authors.lastname: Leibovici
authors.forename: Galia
authors.initials: G
authors.lastname: Kariv
authors.forename: Mical
authors.initials: M
authors.lastname: Paul
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000401:mortality*; D020000:Decision Support Systems, Clinical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: appropriate antibiotic treatment; documented bacterial infections; mortality