title: A case of Muir-Torre syndrome with multiple cancers of bilateral eyelids and breast.
abstract: We report a case of Muir-Torre syndrome (MTS) with a very rare combination of cancers, involving bilateral eyelid cancers and breast cancer. A 71-year-old female with a history of breast cancer from 18 years prior presented with bilateral eyelid tumors. One of her siblings had lung cancer, and another had pancreatic cancer. She underwent excisional biopsy of the eyelid tumors and histopathology revealed sebaceous carcinoma of the right eyelid and basal cell carcinoma of the left. She was diagnosed with MTS: a skin cancer associated with visceral malignancy. Immunohistochemical tests for mutS homolog 2 showed a lack of expression in both eyelid carcinomas.
authors.affiliation: Department of Ophthalmology Faculty of Medicine, Kagoshima University Graduate School of Medicine and Dental Sciences, Kagoshima, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Kamisasanuki
authors.forename: Eisuke
authors.initials: E
authors.lastname: Uchino
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Fukushima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Ishibashi
authors.forename: Taiji
authors.initials: T
authors.lastname: Sakamoto
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D005142:Eyelid Neoplasms / Q000473:pathology*; D005192:Family Health; D005260:Female; D006801:Humans; D055653:Muir-Torre Syndrome / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*
keywords: Breast neoplasms; Eyelids; Immunohistochemistry; Pancreatic neoplasms