title: Synthesis, physical properties and cytotoxicity of stilbene-triazine derivatives containing amino acid groups as fluorescent whitening agents.
abstract: A series of novel stilbene-triazine derivatives containing amino acid groups were synthesized and screened to evaluate their cytotoxicity. The UV absorptions of the derivatives were in the range of 240-450 nm. The absorption peaks of the cis-isomers and trans-isomers were in 281-291 nm and 353-361 nm, respectively. Their fluorescence emission peaks of the derivatives were located in the range of 400-650 nm. The whiteness data indicated that all the stilbene-triazine-amino acid derivatives showed excellent whitening effect on cotton fiber compared to untreated cotton. The preliminary cytotoxicity of these derivatives on a mouse fibroblast cell line (L-929 cells) was also investigated. The results showed that the compounds (7a-h) were nontoxic to L-929 cells as fluorescent whitening agents.
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, China.
authors.forename: Maosheng
authors.initials: M
authors.lastname: Wan
authors.forename: Shaoli
authors.initials: S
authors.lastname: Zhou
authors.forename: Peifu
authors.initials: P
authors.lastname: Jiao
authors.forename: Chengbo
authors.initials: C
authors.lastname: Cao
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D002460:Cell Line; D005347:Fibroblasts / Q000166:cytology; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D005456:Fluorescent Dyes; D013267:Stilbenes; D014227:Triazines