title: Oxazepine synthesis by copper-catalyzed intermolecular cascade reactions between O-propargylic oximes and dipolarophiles.
abstract: Three-step cascade: Oxazepine derivatives were efficiently prepared from O-propargylic oximes and dipolarophiles through copper-catalyzed cascade reactions which proceed through a 2,3-rearrangement, [3+2] cycloaddition, and subsequent 1,3-oxygen rearrangement. The process involves the cleavage of C- and N-O bonds.
authors.affiliation: Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Sendai, 980-8578, Japan. itaru-n@m.tohoku.ac.jp
authors.forename: Itaru
authors.initials: I
authors.lastname: Nakamura
authors.forename: Yu
authors.initials: Y
authors.lastname: Kudo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Terada
keywords: copper; cycloaddition; heterocycles; rearrangement; synthetic methods