title: Ratiometric and absolute water-soluble fluorescent tripodal zinc sensor and its application in killing human lung cancer cells.
abstract: A new "naked-eye" and ratiometric fluorescent zinc sensor (TAQ) of carboxamidoquinoline with 2-chloro-N-(quinol-8-yl)-acetamide as a receptor was designed and synthesized. The sensor shows good water solubility and high selectivity for sensing; about a 15-fold increase in fluorescence quantum yield and a 100 nm red-shift of fluorescence emission upon binding Zn²⁺ in aqueous HEPES buffer solution are observed. The human lung cancer cell line (A549) activity is also demonstrated.
authors.affiliation: Department of Chemistry, Bengal Engineering and Science University, Shibpur, Howrah, 711103, West Bengal, India. spgoswamical@yahoo.com
authors.forename: Shyamaprosad
authors.initials: S
authors.lastname: Goswami
authors.forename: Avijit Kumar
authors.initials: AK
authors.lastname: Das
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Aich
authors.forename: Abhishek
authors.initials: A
authors.lastname: Manna
authors.forename: Sibaprasad
authors.initials: S
authors.lastname: Maity
authors.forename: Kalyani
authors.initials: K
authors.lastname: Khanra
authors.forename: Nandan
authors.initials: N
authors.lastname: Bhattacharyya
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D016923:Cell Death / Q000502:physiology*; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D012995:Solubility; D013050:Spectrometry, Fluorescence / Q000379:methods; D014867:Water / Q000737:chemistry / Q000378:metabolism*; D015032:Zinc / Q000737:chemistry / Q000378:metabolism*
chemical_list: D005456:Fluorescent Dyes; D014867:Water; D015032:Zinc