title: Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy.
abstract: Precise techniques for the measurement of maxillary bone mineral density (BMD) are useful for the early diagnosis of systemic diseases. The aim of this study was to compare in vivo the efficacy of dual-energy x-ray absorptiometry (DXA) and radiographic densitometry for the measurement of BMD after systemic administration of sodium alendronate. Wistar rats were randomly allocated to a control group (n = 5), which received distilled water, and a sodium alendronate group (n = 8), which received two doses of chemically pure sodium alendronate (1 mg/kg) per week. After 8 weeks, the animals were euthanized, the tibias were removed, and the BMD of the proximal tibial metaphysis was analyzed radiographically and by DXA. The data were subjected to statistical analysis by the Kruskal-Wallis test at a significance level of 5%. Both of the techniques revealed that the alendronate-treated group had a significantly higher BMD (p < 0.05) than the control group after 8 weeks of treatment. Comparing the groups with and without alendronate therapy revealed increases of 14.9% and 29.6% in BMD, as detected radiographically and by DXA, respectively. In conclusion, both of the methods were able to detect an increase in BMD of the proximal tibial metaphysis after alendronate therapy.
authors.affiliation: Department of Pediatric Clinics, Preventive and Community Dentistry, School of Dentistry of Ribeirão Preto, Univ de São Paulo, Ribeirão Preto, SP, Brazil.
authors.forename: Marília Pacífico
authors.initials: MP
authors.lastname: Lucisano
authors.forename: Paulo
authors.initials: P
authors.lastname: Nelson-Filho
authors.forename: Leslie
authors.initials: L
authors.lastname: Morse
authors.forename: Ricardo
authors.initials: R
authors.lastname: Battaglino
authors.forename: Plauto Christopher Aranha
authors.initials: PC
authors.lastname: Watanabe
authors.forename: Raquel Assed Bezerra da
authors.initials: RA
authors.lastname: Silva
authors.forename: Lea Assed Bezerra da
authors.initials: LA
authors.lastname: Silva
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D019386:Alendronate / Q000627:therapeutic use*; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D003720:Densitometry / Q000379:methods*; D008297:Male; D010024:Osteoporosis / Q000000981:diagnostic imaging; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013977:Tibia / Q000000981:diagnostic imaging
chemical_list: D050071:Bone Density Conservation Agents; D019386:Alendronate