title: [Response to thalidomide in scleromyxedema].
abstract: The scleromyxedema is a rare condition characterized by hyperproliferation of fibroblasts with increased dermal deposition of mucin and frequently associated with monoclonal gammopathy of undetermined significance. Various treatments have been reported, with inconsistent results. In addition, the rarity of the disease and the lack of randomized controlled trials results in treatment options derived from anecdotal reports. We describe the case of a 52 year-old female patient diagnosed with scleromyxedema who developed a monoclonal gammopathy, with adequate response to thalidomide. The follow up of these patients is important due to the risk of progression to multiple myeloma and complications related to systemic treatments.
authors.affiliation: Servicio de Dermatología, Hospital Privado Centro Médico de Córdoba, Argentina.
authors.forename: María Florencia
authors.initials: MF
authors.lastname: Pascualini
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Caballero Escuti
authors.forename: Enrique
authors.initials: E
authors.lastname: Valente
authors.forename: María
authors.initials: M
authors.lastname: Kurpis
authors.forename: Alejandro
authors.initials: A
authors.lastname: Ruiz Lascano
mesh_terms: D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications / Q000175:diagnosis; D053718:Scleromyxedema / Q000188:drug therapy* / Q000209:etiology; D013792:Thalidomide / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D013792:Thalidomide
keywords: monoclonal gammopathy; scleromyxedema; thalidomide