title: Transcriptional regulation of effector and memory CD8+ T cell fates.
abstract: Immunity to intracellular pathogens and cancer relies on the generation of robust CD8(+) T cell effector responses as well as the establishment of immunological memory. During a primary immune response CD8(+) T cells experience diverse extracellular environmental cues and cell-cell interactions that trigger downstream transcriptional programs ultimately guiding a CD8(+) T cell to undertake either an effector or a memory cell fate. Here, we discuss our current understanding of the signaling pathways and transcriptional networks that regulate effector and memory commitment in CD8(+) T lymphocytes.
authors.affiliation: Centre for Lung Infection, Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridge, United Kingdom. jedt2@cam.ac.uk
authors.forename: James E D
authors.initials: JE
authors.lastname: Thaventhiran
authors.forename: Douglas T
authors.initials: DT
authors.lastname: Fearon
authors.forename: Luca
authors.initials: L
authors.lastname: Gattinoni
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D019070:Cell Lineage; D005786:Gene Expression Regulation; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D015398:Signal Transduction; D014158:Transcription, Genetic