title: Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance.
abstract: CD137 is ectopically expressed on Hodgkin and Reed-Sternberg (HRS) cells, causing the removal of the immunostimulatory CD137 ligand from HRS cells as well as from surrounding antigen presenting cells. This inhibits T-cell co-stimulation and supports the immune evasion of Hodgkin's lymphoma.
authors.affiliation: Department of Physiology and Immunology Programme; Yong Loo Lin School of Medicine; National University of Singapore; Singapore.
authors.forename: Wan Lu
authors.initials: WL
authors.lastname: Pang
authors.forename: Weng Tong
authors.initials: WT
authors.lastname: Ho
authors.forename: Herbert
authors.initials: H
authors.lastname: Schwarz
keywords: CD137; Reed-Sternberg cells; classical Hodgkin’s lymphoma; immune evasion