title: Claudins and gastric carcinogenesis.
abstract: Gastric carcinoma arises from aberrant growth of normal gastric mucosa. There is increasing evidence that claudins (CLDNs) may play a critical role in the significant steps of gastric tumorigenesis, from metaplasia to metastasis. The CLDN family which consists of at least 27 member proteins is known to mediate selective permeability in cellular tight junctions. It is now established that CLDNs are differentially altered in gastric cancer and CLDN proteins are believed to play different roles in the growth and progression of gastric cancer.
authors.affiliation: Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. antoi@nus.edu.sg
authors.forename: Omid
authors.initials: O
authors.lastname: Iravani
authors.forename: Benjamin Wei-Rong
authors.initials: BW
authors.lastname: Tay
authors.forename: Pei-Jou
authors.initials: PJ
authors.lastname: Chua
authors.forename: George Wai-Cheong
authors.initials: GW
authors.lastname: Yip
authors.forename: Boon-Huat
authors.initials: BH
authors.lastname: Bay
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D057167:Claudins / Q000502:physiology*; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D013274:Stomach Neoplasms / Q000473:pathology / Q000503:physiopathology*; D019108:Tight Junctions / Q000502:physiology
chemical_list: D057167:Claudins
keywords: cancer progression; claudin; gastric cancer; tight junction