title: Neuro-Behçet's disease, its mimickers and anti-TNF therapy: a case-based review.
abstract: When the central nervous system is the primary affected site in an initial attack of Behçet's disease (BD), the differential diagnosis is particularly challenging. Because the specificity of immunobiologic therapy is growing, the specific diagnosis may impact the chosen therapy. For instance, anti-tumour necrosis factor agents are efficacious in BD but may be harmful in multiple sclerosis or systemic lupus erythematosus. We present two cases with similar neurological features but different diagnosis (BD and systemic lupus erythematosus) as a starting point to review diagnostic and therapeutic approaches for neuro-BD and its differential diagnoses.
authors.affiliation: Universidade Federal de Santa Catarina (UFSC), Florianopolis, Brazil. fabricio.souza.neves@gmail.com.
authors.forename: Fabricio S
authors.initials: FS
authors.lastname: Neves
authors.forename: Rafael M
authors.initials: RM
authors.lastname: Ferreira
authors.forename: Ivanio A
authors.initials: IA
authors.lastname: Pereira
authors.forename: Adriana F
authors.initials: AF
authors.lastname: Zimmermann
authors.forename: Katia
authors.initials: K
authors.lastname: Lin
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D020945:Lupus Vasculitis, Central Nervous System / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D011237:Predictive Value of Tests; D012307:Risk Factors; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha