title: Tigecycline salvage therapy for necrotizing fasciitis caused by Vibrio vulnificus: Case report in a child.
abstract: Necrotizing fasciitis caused by Vibrio vulnificus is rarely reported in children. We describe a 12-year-old immunocompetent boy with necrotizing fasciitis caused by V. vulnificus. He was cured by radical and serial debridement and salvage therapy with intravenous cefpirome plus tigecycline. The in vitro antibacterial activity of combination regimens and a literature review of pediatric V. vulnificus infection are described.
authors.affiliation: Division of Plastic Surgery, Department of Surgery, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Yu-San
authors.initials: YS
authors.lastname: Lin
authors.affiliation: Division of Plastic Surgery, Department of Surgery, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Min-Hsiang
authors.initials: MH
authors.lastname: Hung
authors.affiliation: Institute of Biotechnology, National Cheng Kung University, Tainan, Taiwan; Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
authors.forename: Chi-Chung
authors.initials: CC
authors.lastname: Chen
authors.affiliation: Division of Plastic Surgery, Department of Surgery, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Kuo-Feng
authors.initials: KF
authors.lastname: Huang
authors.affiliation: Department of Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan.
authors.forename: Wen-Chien
authors.initials: WC
authors.lastname: Ko
authors.affiliation: Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan. Electronic address: ashiang68@gmail.com.
authors.forename: Hung-Jen
authors.initials: HJ
authors.lastname: Tang
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D003646:Debridement; D019115:Fasciitis, Necrotizing / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D006801:Humans; D008297:Male; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016879:Salvage Therapy / Q000379:methods*; D000078304:Tigecycline; D016896:Treatment Outcome; D014735:Vibrio Infections / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D041261:Vibrio vulnificus / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline
keywords: Child; Necrotizing fasciitis; Tigecycline; Vibrio vulnificus