title: Orally and topically administered Sparassis crispa (Hanabiratake) improved healing of skin wounds in mice with streptozotocin-induced diabetes.
abstract: Sparassis crispa (SC) contains significant concentrations of β-glucan, which can accelerate wound healing, but the dose dependence for oral administration and the effects of topical administration are unknown. In streptozotocin-induced diabetic mice, dietary SC promoted dose-dependent effective wound healing. Similar wound healing activity was observed when purified SC β-glucan was topically applied to wounds of diabetic mice.
authors.affiliation: Research and Development Center, Unitika Ltd., Kyoto, Japan.
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Kimura
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000473:pathology; D051379:Mice; D020072:Polyporales / Q000737:chemistry; D012867:Skin / Q000187:drug effects / Q000293:injuries / Q000503:physiopathology; D014945:Wound Healing / Q000187:drug effects; D047071:beta-Glucans / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D047071:beta-Glucans