title: Zinc depletion activates the endoplasmic reticulum-stress sensor Ire1 via pleiotropic mechanisms.
abstract: Although zinc deficiency evokes the endoplasmic reticulum (ER)-stress response, the activating mechanism remains obscure. Here we show that in yeast cells, the ER-stress sensor Ire1 was activated upon zinc deficiency. ER-stressing stimuli activating Ire1 are known to include ER accumulation of unfolded proteins and membrane-lipid aberrancy. According to the findings presented here, zinc deficiency causes both types of abnormality.
authors.affiliation: Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan.
authors.forename: Thanh Sy Le
authors.initials: TS
authors.lastname: Nguyen
authors.forename: Kenji
authors.initials: K
authors.lastname: Kohno
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kimata
mesh_terms: D015374:Biosensing Techniques; D004721:Endoplasmic Reticulum / Q000235:genetics / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress; D004722:Endoribonucleases / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000235:genetics*; D017510:Protein Folding; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D015398:Signal Transduction; D015032:Zinc / Q000172:deficiency / Q000378:metabolism*
chemical_list: D008562:Membrane Glycoproteins; D029701:Saccharomyces cerevisiae Proteins; C082863:IRE1 protein, S cerevisiae; D017346:Protein Serine-Threonine Kinases; D004722:Endoribonucleases; D015032:Zinc