title: The effectiveness of lifestyle interventions to reduce cardiovascular risk in patients with severe mental disorders: meta-analysis of intervention studies.
abstract: Patients with severe mental illness have higher prevalences of cardiovascular risk factors (CRF). The objective is to determine whether interventions to modify lifestyles in these patients reduce anthropometric and analytical parameters related to CRF in comparison to routine clinical practice. Systematic review of controlled clinical trials with lifestyle intervention in Medline, Cochrane Library, Embase, PsycINFO and CINALH. Change in body mass index, waist circumference, cholesterol, triglycerides and blood sugar. Meta-analyses were performed using random effects models to estimate the weighted mean difference. Heterogeneity was determined using i(2) statistical and subgroups analyses. 26 studies were selected. Lifestyle interventions decrease anthropometric and analytical parameters at 3 months follow up. At 6 and 12 months, the differences between the intervention and control groups were maintained, although with less precision. More studies with larger samples and long-term follow-up are needed.
authors.affiliation: Àmbit Atenció Primària Barcelona, Institut Català de la Salut, Barcelona, Spain, mifsanmartin.bcn.ics@gencat.cat.
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Fernández-San-Martín
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Martín-López
authors.forename: Roser
authors.initials: R
authors.lastname: Masa-Font
authors.forename: Noemí
authors.initials: N
authors.lastname: Olona-Tabueña
authors.forename: Yuani
authors.initials: Y
authors.lastname: Roman
authors.forename: Jaume
authors.initials: J
authors.lastname: Martin-Royo
authors.forename: Silvia
authors.initials: S
authors.lastname: Oller-Canet
authors.forename: Susana
authors.initials: S
authors.lastname: González-Tejón
authors.forename: Luisa
authors.initials: L
authors.lastname: San-Emeterio
authors.forename: Albert
authors.initials: A
authors.lastname: Barroso-Garcia
authors.forename: Lidia
authors.initials: L
authors.lastname: Viñas-Cabrera
authors.forename: Gemma
authors.initials: G
authors.lastname: Flores-Mateo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy / Q000453:epidemiology*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000453:epidemiology* / Q000517:prevention & control*; D015897:Comorbidity; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000139:chemically induced / Q000453:epidemiology*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D014150:Antipsychotic Agents