title: miR-150 promotes the proliferation of lung cancer cells by targeting P53.
abstract: Lung cancer is one of the most common causes for cancer-related death. Previous studies suggested that uncontrolled cell proliferation induced by activation of pro-cancer genes or inhibition of cancer suppressor genes plays an important role in the pathogenesis of lung cancer. Here, we demonstrate that miR-150 is aberrantly upregulated in lung cancer tissue and negatively correlates with the expression of the proapoptotic gene p53 but not EGR2. We show that miR-150 specifically targets the 3'-UTR of p53 and regulates its expression. Inhibition of miR-150 effectively delays cell proliferation and promotes apoptosis, accompanied by increased p53 protein expression. Our data reveals the mechanisms underlying miR-150 regulated lung cancer pathogenesis, which might be beneficial for lung cancer therapy.
authors.affiliation: Department of Throracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. zhangnidoc@vip.163.com
authors.forename: Ni
authors.initials: N
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Wei
authors.forename: Lijun
authors.initials: L
authors.lastname: Xu
mesh_terms: D001483:Base Sequence; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism / Q000473:pathology*; D049109:Cell Proliferation; D017931:DNA Primers; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D035683:MicroRNAs / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
chemical_list: D017931:DNA Primers; D035683:MicroRNAs; D016159:Tumor Suppressor Protein p53; C533097:MIR150, human
keywords: Cell proliferation; Lung cancer; P53; miR-150