title: Subretinal drusenoid deposits with increased autofluorescence in eyes with reticular pseudodrusen.
abstract: OBJECTIVE
  To characterize a variant type of drusenoid deposit with different imaging features in comparison to reticular pseudodrusen.
  
  
  METHODS
  Retrospective observational consecutive case series. Eyes showing atypical drusenoid lesions were sorted out from 257 eyes of 133 patients previously diagnosed as reticular pseudodrusen. Eyes were evaluated using color fundus photography, confocal scanning laser ophthalmoscopy, and spectral domain optical coherence tomography.
  
  
  RESULTS
  A variant type of drusenoid deposits showing different imaging features from reticular pseudodrusen was found in 17 eyes of 12 patients (6.6%). The mean age of patients was 62.7 ± 11.6 years, and all patients were women. These deposits were observed as yellowish white, round to oval lesions on color photographs, located under the sensory retina and above the retinal pigment epithelium on spectral domain optical coherence tomography similar to reticular pseudodrusen. However, they were present in a smaller number as discrete lesions and showed increased autofluorescence. None of them were accompanied by late age-related macular degeneration.
  
  
  CONCLUSIONS
  Subretinal drusenoid deposits are not homogeneous and can be classified into two types according to the fundus autofluorescence. Multimodal imaging tests are needed for the differential diagnosis of subretinal drusenoid deposits.
authors.affiliation: *Department of Ophthalmology, Chung-Ang University, College of Medicine, Seoul, Korea; and †Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Mee Yon
authors.initials: MY
authors.lastname: Lee
authors.forename: Don-Il
authors.initials: DI
authors.lastname: Ham
mesh_terms: D000328:Adult; D000368:Aged; D004396:Coloring Agents; D003937:Diagnosis, Differential; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008268:Macular Degeneration / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D009887:Ophthalmoscopy; D010781:Photography; D015593:Retinal Drusen / Q000145:classification / Q000175:diagnosis*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green