title: Surgical interventions for obesity and metabolic disease.
abstract: Obesity continues to be a growing problem in both the developed and the developing world. Its strong link with co-morbid conditions such as type 2 diabetes, hypertension, obstructive sleep apnea, and depression presents an increasing strain on health care systems around the world. Diet and exercise alone has been shown to be largely ineffective at managing obesity. Surgery is the only evidence-based method of allowing morbidly obese patients to lose weight and to maintain this weight loss. Weight-reduction in obese individuals from bariatric surgery has also been found to markedly improve obesity-related co-morbid conditions, particularly, type 2-diabetes. Diabetic remission from bariatric surgery has resulted in the inclusion of bariatric surgery, by the International Diabetes Taskforce, as a treatment modality for type-2 diabetes. This consensus statement named four surgical options that have been found to be effective in both weight-loss and in inducing diabetes remission. These four surgical procedures lead to weight-loss through restrictive and malabsorptive mechanisms. Each specific operation has a different level of efficacy in inducing weight-loss and diabetic remission, as well as distinct types and rates of complications. This article reviews the best evidence that exists for the effectiveness and complications of these four operations.
authors.affiliation: Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Lan
authors.initials: L
authors.lastname: Vu
authors.forename: Noah J
authors.initials: NJ
authors.lastname: Switzer
authors.forename: Christopher
authors.initials: C
authors.lastname: De Gara
authors.forename: Shahzeer
authors.initials: S
authors.lastname: Karmali
mesh_terms: D050110:Bariatric Surgery; D015904:Biliopancreatic Diversion / Q000379:methods; D006801:Humans; D010535:Laparoscopy; D008659:Metabolic Diseases / Q000209:etiology / Q000601:surgery*; D009767:Obesity, Morbid / Q000150:complications* / Q000601:surgery*