title: Whole-genome sequence analysis of a Korean G11P[25] rotavirus strain identifies several porcine-human reassortant events.
abstract: A rare rotavirus, RVA/Human-wt/KOR/CAU12-2/2012/G11P[25], was isolated from a 16-year-old female with fever and diarrhea during the 2012 rotavirus surveillance in South Korea using a cell culture system, and its full genome sequence was determined and analyzed. Strain CAU12-2 exhibited a G11-P[25]-I12-R1-C1-M1-A1-N1-T1-E1-H1 genotype constellation. Phylogenetic analysis of this strain revealed that it is a human-porcine reassortant of two distant relatives of the G11 strains circulating in the world. The VP7 and VP4 genes are most closely related to those of human G11P[25] viruses (Dhaka6, KTM368, and N-38 strains) identified in South Asia, whereas the VP1 gene originated from a porcine G11P[7] virus (YM strain) that was identified in South America. The VP6 gene was found to belong to the new genotype I12. This study indicates that the G11-P[25]-I12 genotype was introduced into the South Korean population by interspecies transmissions of human and animal rotaviruses, followed by multiple reassortment events.
authors.affiliation: Department of Microbiology and Research Center for Medical Sciences, Chung-Ang University College of Medicine, Seoul, South Korea.
authors.forename: Van Thai
authors.initials: VT
authors.lastname: Than
authors.forename: Jong-Hwa
authors.initials: JH
authors.lastname: Park
authors.forename: In Sik
authors.initials: IS
authors.lastname: Chung
authors.forename: Jong Bum
authors.initials: JB
authors.lastname: Kim
authors.forename: Wonyong
authors.initials: W
authors.lastname: Kim
mesh_terms: D000818:Animals; D003967:Diarrhea / Q000821:virology; D016679:Genome, Viral; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D016865:Reassortant Viruses / Q000235:genetics*; D056910:Republic of Korea; D012401:Rotavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology / Q000821:virology*; D017422:Sequence Analysis, DNA; D013552:Swine / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins