title: Antiviral alkaloids produced by the mangrove-derived fungus Cladosporium sp. PJX-41.
abstract: Six new indole alkaloids including five new glyantrypine derivatives (1, 2a, 2b, 3, 4) and a new pyrazinoquinazoline derivative (5), together with eight known alkaloids (6-13), were isolated from the culture of the mangrove-derived fungus Cladosporium sp. PJX-41. Their structures were elucidated primarily by spectroscopic and physical data. The absolute configurations of compounds 1-9 were established on the basis of CD, NOESY data, and single-crystal X-ray diffraction analysis. Compounds 2b, 5, 7-9, and 11 exhibited significant activities against influenza virus A (H1N1), with IC50 values of 82-89 μM.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
authors.forename: Jixing
authors.initials: J
authors.lastname: Peng
authors.forename: Tao
authors.initials: T
authors.lastname: Lin
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Xin
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
authors.forename: Dehai
authors.initials: D
authors.lastname: Li
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002681:China; D002963:Cladosporium / Q000737:chemistry*; D018360:Crystallography, X-Ray; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D043982:Rhizophoraceae / Q000382:microbiology
chemical_list: D000998:Antiviral Agents; D026121:Indole Alkaloids