title: Transition-metal-free Sonogashira-type cross-coupling of alkynes with fluoroarenes.
abstract: A novel, inexpensive, and efficient palladium-, copper-, ligand-, and amine-free Sonogashira-type cross-coupling reaction of terminal alkynes with unreactive aryl fluorides in the presence of sodium, sodium methoxide, and calcium hydroxide under the assistance of a Grignard reagent was developed. A plausible mechanism was also suggested.
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Shanghai 200237, China, and Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , Shanghai 200032, China.
authors.forename: Guanyi
authors.initials: G
authors.lastname: Jin
authors.forename: Xuxue
authors.initials: X
authors.lastname: Zhang
authors.forename: Song
authors.initials: S
authors.lastname: Cao
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry; D005459:Fluorides / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007202:Indicators and Reagents; D008024:Ligands; D028561:Transition Elements; D010165:Palladium; D003300:Copper; D005459:Fluorides