title: Meiotic and mitotic recombination in meiosis.
abstract: Meiotic crossovers facilitate the segregation of homologous chromosomes and increase genetic diversity. The formation of meiotic crossovers was previously posited to occur via two pathways, with the relative use of each pathway varying between organisms; however, this paradigm could not explain all crossovers, and many of the key proteins involved were unidentified. Recent studies that identify some of these proteins reinforce and expand the model of two meiotic crossover pathways. The results provide novel insights into the evolutionary origins of the pathways, suggesting that one is similar to a mitotic DNA repair pathway and the other evolved to incorporate special features unique to meiosis.
authors.affiliation: Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Kathryn P
authors.initials: KP
authors.lastname: Kohl
authors.forename: Jeff
authors.initials: J
authors.lastname: Sekelsky
mesh_terms: D000818:Animals; D059765:Homologous Recombination / Q000235:genetics*; D006801:Humans; D008540:Meiosis / Q000235:genetics*; D008938:Mitosis / Q000235:genetics*; D009154:Mutation; D015003:Yeasts / Q000235:genetics
keywords: meiotic recombination; mitotic recombination