title: [The myeloproliferative neoplasms-related glomerulopathy].
abstract: OBJECTIVE
  Myeloproliferative neoplasms (MPN) are hematological disorders characterized by clonal expansion of one or more medullary lines. Renal complications are rare, chiefly as acute renal failure. Glomerular involvement is exceptional
  
  
  METHODS
  We report on a retrospective multicenter case series of eight patients who presented with a glomerulopathy (GP) associated with MPN RESULTS: All GP were revealed by a major proteinuria frequently associated with nephrotic syndrome and oedema. Histology was mainly characterized by lesions of focal segmental glomerulosclerosis associated with increased mesangial cellularity. The pathophysiology is still unclear but platelet-derived growth factor (PDGF) and transforming growth factor-β (TGF-β), which play a central role in the MPN may be involved. A majority of patients developed chronic renal failure despite of a therapy intended to block the renin-angiotensin system
  
  
  CONCLUSIONS
  Monitoring of proteinuria during the follow-up of MPN would allow earlier diagnosis of renal involvement. Further studies on a larger scale are needed to specify the pathophysiological mechanisms involved and the management of these complications.
authors.affiliation: Service de médecine interne, CHU Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: A
authors.initials: A
authors.lastname: Bardy
authors.affiliation: Service de néphrologie, CHU Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: A
authors.initials: A
authors.lastname: Tiple
authors.affiliation: Service d'anatomopathologie, hôpital Necker, Assistance publique-Hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France; Université Paris-Descartes, 75006 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Rabant
authors.affiliation: Service d'anatomie pathologique, CHU Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Kémény
authors.affiliation: Service de néphrologie adultes, hôpital Necker, Assistance publique-Hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France; Inserm U845, hôpital Necker, Assistance publique-Hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France.
authors.forename: K
authors.initials: K
authors.lastname: El Karoui
authors.affiliation: Service de médecine interne, CHU Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: M
authors.initials: M
authors.lastname: Hermet
authors.affiliation: Service de médecine interne, CHU Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: G
authors.initials: G
authors.lastname: Guettrot-Imbert
authors.affiliation: Service de néphrologie, CHU Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: P
authors.initials: P
authors.lastname: Deteix
authors.affiliation: Service d'hématologie clinique, CHU Estaing Clermont-Ferrand, 1, place Lucie-Aubrac, 63000 Clermont-Ferrand, France.
authors.forename: J-O
authors.initials: JO
authors.lastname: Bay
authors.affiliation: Service de médecine interne, CHU Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: O
authors.initials: O
authors.lastname: Aumaître
authors.affiliation: Service de médecine interne, CHU Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France. Electronic address: mandre@chu-clermontferrand.fr.
authors.forename: M
authors.initials: M
authors.lastname: André
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D012189:Retrospective Studies
keywords: Glomerulopathy; Glomérulopathies; Myeloproliferative neoplasm; Néoplasies myéloprolifératives