title: Pancreatic metastasis from mixed adenoneuroendocrine carcinoma of the uterine cervix: a case report.
abstract: Metastatic cancers of the pancreas are rare, accounting for approximately 2-4% of all pancreatic malignancies. Renal cell carcinoma is the most common solid tumor that metastasizes to the pancreas. Here, we present a case of uterine cervical carcinoma metastasizing to the pancreas and review the literature regarding this rare event. A 44-year-old woman with a uterine cervical tumor had undergone radical hysterectomy and had been diagnosed pathologically with stage Ib mixed adenoneuroendocrine carcinoma in 2004. She underwent concurrent radiotherapy and chemotherapy postoperatively. Pulmonary metastases subsequently appeared in 2008 and 2011, and she underwent complete resection of the lung tumors by video-assisted thoracic surgery. Although she was followed up without any treatment and with no other recurrences, positron emission tomography revealed an area of abnormal uptake within the pancreatic body in 2012. Enhanced computed tomography demonstrated a 20-mm lesion in the pancreatic body and upstream pancreatic duct dilatation. Endoscopic ultrasonography-guided fine needle aspiration was performed and pathological examination suggested neuroendocrine carcinoma (NEC). On the basis of these results and the patient's oncological background, lesions in the pancreatic body were diagnosed as secondary metastasis from the cervical carcinoma that had been treated 8 years earlier. No other distant metastases were visualized, and the patient subsequently underwent middle pancreatectomy. Pathological examination showed NEC consistent with pancreatic metastasis from the uterine cervical carcinoma. The patient has survived 7 months since the middle pancreatectomy without any signs of local recurrence or other metastatic lesions.
authors.affiliation: Departments of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Nishimura
authors.forename: Hideaki
authors.initials: H
authors.lastname: Naoe
authors.forename: Shunpei
authors.initials: S
authors.lastname: Hashigo
authors.forename: Hideharu
authors.initials: H
authors.lastname: Tsutsumi
authors.forename: Shotaro
authors.initials: S
authors.lastname: Ishii
authors.forename: Takeyasu
authors.initials: T
authors.lastname: Konoe
authors.forename: Takehisa
authors.initials: T
authors.lastname: Watanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Shono
authors.forename: Kouichi
authors.initials: K
authors.lastname: Sakurai
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Takaishi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ikuta
authors.forename: Akira
authors.initials: A
authors.lastname: Chikamoto
authors.forename: Motohiko
authors.initials: M
authors.lastname: Tanaka
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Iyama
authors.forename: Hideo
authors.initials: H
authors.lastname: Baba
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Katabuchi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sasaki
keywords: Endoscopic ultrasonography-guided fine needle aspiration; Middle pancreatectomy; Pancreatic metastasis; Uterine cervical mixed adenoneuroendocrine carcinoma