title: [FGF-23 and Klotho protein - new markers in chronic kidney disease?].
abstract: Disorders of calcium and phosphate metabolism are among the major problems in patients with chronic kidney disease (CKD), especially undergoing chronic dialysis. Besides the classic parathyroid-kidney axis, in recent years the existence of an endocrinological bone-kidney axis has been established, which allows better explanation of calcium and phosphate metabolism pathophysiology and secondary hyperparathyroidism in CKD. Fibroblast growth factor 23 (FGF-23) and its co-factor alpha-Klotho protein are the most important factors in the axis. The role of FGF-23 and Klotho protein, their mechanisms of action and significance in CKD have been presented. In ealy stages of CKD the increase of FGF-23 level precedes the decline in vitamin 1.25 (OH)2D3 and the increase of PTH level. Some studies showed correlation between the elevated FGF-23 level and increased mortality from cardiovascular disease in patients with chronic kidney disease. Clinical usefulness of determinations of FGF-23 and Klotho protein in chronic kidney disease is currently investigated.
authors.affiliation: NZSOZ Avitum Stacja Dializ w Drezdenku.
authors.forename: Izabela
authors.initials: I
authors.lastname: Mituła
authors.forename: Edyta
authors.initials: E
authors.lastname: Gołembiewska
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Ciechanowski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Siuda
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D000090265:Klotho Proteins; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins