title: Uncommon synchronous association between ovarian carcinoma and gastrointestinal stromal tumor: a case study and literature review.
abstract: BACKGROUND
  The association of gastrointestinal stromal tumors (GIST) and other cancers is well known, but its synchronous occurrence with gynecological malignancies is very uncommon. Usually, the diagnosis is accidentally established. We describe a patient with GIST and concurrent ovarian cancer and discuss the clinical implications of this finding.
  
  
  METHODS
  A 64-year-old woman with a prior diagnosis of ovarian cancer developed a second recurrence after having undergone two operations and adjuvant chemotherapy. While tumor debulking was performed, a small, nonsuspicious lesion was removed from the greater curvature of the stomach. Histology revealed a GIST.
  
  
  CONCLUSIONS
  The association of GIST and ovarian cancer is a rarity and its synchronicity may alter the oncological prognosis and therapy of the patient.
authors.affiliation: Department of Gynecology, Charité Universitätsmedizin Berlin, Berlin, Germany. gdifavero@hotmail.com
authors.forename: Giovanni
authors.initials: G
authors.lastname: Favero
authors.forename: Tatiana
authors.initials: T
authors.lastname: Pfiffer
authors.forename: Wolfram F J
authors.initials: WF
authors.lastname: Riedlinger
authors.forename: Vito
authors.initials: V
authors.lastname: Chiantera
authors.forename: Achim
authors.initials: A
authors.lastname: Schneider
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis; D018394:CA-125 Antigen / Q000097:blood; D016190:Carboplatin / Q000008:administration & dosage; D000077216:Carcinoma, Ovarian Epithelial; D017024:Chemotherapy, Adjuvant; D003082:Colectomy; D015653:Cystectomy / Q000379:methods; D005260:Female; D005743:Gastrectomy / Q000379:methods; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D010052:Ovariectomy; D017239:Paclitaxel / Q000008:administration & dosage; D010180:Pancreatectomy; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D058994:Salpingectomy; D013156:Splenectomy; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D016190:Carboplatin; D019009:Proto-Oncogene Proteins c-kit; D017239:Paclitaxel