title: CTX-M-123, a novel hybrid of the CTX-M-1 and CTX-M-9 Group β-lactamases recovered from Escherichia coli isolates in China.
abstract: The chimeric bla(CTX-M-123) gene was identified in two ceftazidime-resistant Escherichia coli isolates from animals in different Chinese provinces. Like other CTX-M-1/9 group hybrids (CTX-M-64 and CTX-M-132), the ends (amino acids 1 to 135 and 234 to 291) of CTX-M-123 match CTX-M-15 while the central part (122 to 241) matches CTX-M-14. bla(CTX-M-123) is carried on related, but not identical, ~90-kb IncI1 plasmids in the two isolates, and one isolate simultaneously carries the group 1 blaCTX-M-55 gene on an additional IncI2 plasmid.
authors.affiliation: College of Veterinary Medicine, National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, South China Agricultural University, Guangzhou, People's Republic of China.
authors.forename: Dandan
authors.initials: D
authors.lastname: He
authors.forename: Sally R
authors.initials: SR
authors.lastname: Partridge
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Shen
authors.forename: Zhenling
authors.initials: Z
authors.lastname: Zeng
authors.forename: Lanping
authors.initials: L
authors.lastname: Liu
authors.forename: Lili
authors.initials: L
authors.lastname: Rao
authors.forename: Luchao
authors.initials: L
authors.lastname: Lv
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Liu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D002442:Ceftazidime / Q000494:pharmacology; D002681:China; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D029968:Escherichia coli Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D005798:Genes, Bacterial; D059765:Homologous Recombination; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D050506:Mutant Chimeric Proteins / Q000235:genetics / Q000378:metabolism*; D010957:Plasmids / Q000235:genetics / Q000378:metabolism; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D050506:Mutant Chimeric Proteins; D002442:Ceftazidime; C412613:CTX-M-9 protein, E coli; C055184:beta-lactamase TEM-3; D001618:beta-Lactamases