title: New Lignans from the Leaves and Stems of Kadsura philippinensis.
abstract: Three novel C19 homolignans, taiwankadsurins D (1), E (2) and F (4), and two new C18 lignans kadsuphilins N (3) and O (5) were isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The structures of compounds 1-5 were determined by spectroscopic analyses, especially 2D NMR techniques. The structure of compound 5 was further confirmed by X-ray crystallographic analysis. Compounds 1 and 2 have a 3,4-{1'-[(Z)-2''-methoxy-2''-oxoethylidene]}-pentano(2,3-dihydrobenzo[b]furano)-3-(2'''-methoxycarbonyl-2'''-hydroxy-2''',3'-epoxide) skeleton.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, 1, Sec. 1, Jen-Ai Rd., Taipei 100, Taiwan. z10108042@email.ncku.edu.tw
authors.forename: Yu-Chi
authors.initials: YC
authors.lastname: Lin
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Cheng
authors.forename: Chia-Ching
authors.initials: CC
authors.lastname: Liaw
authors.forename: I-Wen
authors.initials: IW
authors.lastname: Lo
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Chiang
authors.forename: Chang-Hung
authors.initials: CH
authors.lastname: Chou
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
mesh_terms: D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000032:analysis / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*
chemical_list: D017705:Lignans; D010936:Plant Extracts