title: Dynamic combinatorial libraries: from exploring molecular recognition to systems chemistry.
abstract: Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other. Dynamic combinatorial libraries (DCLs) are powerful tools for discovering the unexpected and have given rise to many fascinating molecules, ranging from interlocked structures to self-replicators. Furthermore, dynamic combinatorial molecular networks can produce emergent properties at systems level, which provide exciting new opportunities in systems chemistry. In this perspective we will highlight some new methodologies in this field and analyze selected examples of DCLs that are under thermodynamic control, leading to synthetic receptors, catalytic systems, and complex self-assembled supramolecular architectures. Also reviewed are extensions of the principles of DCC to systems that are not at equilibrium and may therefore harbor richer functional behavior. Examples include self-replication and molecular machines.
authors.affiliation: Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Li
authors.forename: Piotr
authors.initials: P
authors.lastname: Nowak
authors.forename: Sijbren
authors.initials: S
authors.lastname: Otto
mesh_terms: D020650:Combinatorial Chemistry Techniques; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013816:Thermodynamics
chemical_list: D046911:Macromolecular Substances