title: [Adverse effects of seasonal flu vaccine and new influenza A (H1N1) vaccine in health care workers].
abstract: OBJECTIVE
  To assess and compare adverse effects of Seasonal Influenza Vaccine (SIV) and new Influenza A(H1N1) Vaccine (AIV) in health care workers.
  
  
  METHODS
  Multicenter cross-sectional study in health care workers from acute care hospitals, primary health care centers, social centers, mental health centers and a geriatric hospital participating in the 2009 vaccination campaign. Self-administered questionnaires were sent to all workers vaccinated with SIV and/or AIV.
  
  
  RESULTS
  527 valid questionnaires were collected out of 1123 sent to SIV vaccinated workers (46.9%), and 241 out of 461 sent to AIV vaccinated workers (52.%%). Participant workers include 527 vaccinated only with SIV, 117 first vaccinated with SIV and later with AIV (SIV+AIV), and 125 vaccinated only with AIV. Overall, 18.4% (95%CI 15.1-21.7) of workers vaccinated only with SIV reported adverse effects, as compared to 45.3% (95I 36.3-54.3) reporting adverse effects to AIV in the SIV+AIV group and 46.4% (95%CI 37.7-55.1) of workers vaccinated only with AIV. In all participants the most common adverseeffect was a local reaction. Women wre more reactive to both SIV and AIV than men. In all age groups SIV vaccination alone caused fewer reactions that either AIV only or the combination of SIV+AIV, with the exception of workers below 29 years of age.
  
  
  CONCLUSIONS
  AIV was associated with more reactions than SIV, with no differences observed in relation to administration sequence. There were differences by sex and age, but reactions always occurred more commonly with AIV.
authors.affiliation: Hospital Universitari Sant Joan. Reus, 43205, Spain.jingles@grupsagessa.cat.
authors.forename: Joan Inglés
authors.initials: JI
authors.lastname: Torruella
authors.forename: Rosa Gil
authors.initials: RG
authors.lastname: Soto
authors.forename: Rosa Carreras
authors.initials: RC
authors.lastname: Valls
authors.forename: Judit Valverde
authors.initials: JV
authors.lastname: Lozano
authors.forename: Dolors Benito
authors.initials: DB
authors.lastname: Carreras
authors.forename: Arnau Besora
authors.initials: AB
authors.lastname: Cunillera
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology; D005260:Female; D006282:Health Personnel; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects*; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D012621:Seasons; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D007252:Influenza Vaccines