title: Epigenetic regulation of transcription by RNA polymerase III.
abstract: Chromatin participates actively in all DNA transactions and all phenomena directly under the influence of chromatin are explained by epigenetic mechanisms. The genes transcribed by RNA polymerase (pol) III are generally found in regions free of nucleosomes, the structural units of chromatin. Yet, histone modifications and positions of nucleosomes in the gene flanking regions have been reported to show direct correlation with activity status of these genes. Gene-specific as well as genome-wide studies have also revealed association of several epigenetic components with pol III-transcribed genes. This review presents a summary of the research in past many years, which have gathered enough evidence to conclude that pol III-transcribed genes are important components of an epigenome.
authors.affiliation: Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Uppal Road, Hyderabad 500007, India. Electronic address: purnima@ccmb.res.in.
authors.forename: Purnima
authors.initials: P
authors.lastname: Bhargava
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D012320:RNA Polymerase III / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D012320:RNA Polymerase III
keywords: Chromatin remodeling; H2A.Z; Histone chaperones; Histone modifications; Nucleosome positioning; RNA polymerase III