title: 99mTc-oxidronate uptake within urothelial carcinoma confirmed with SPECT/CT imaging.
abstract: A 63-year-old woman with recurrent urothelial carcinoma was referred for skeletal scintigraphy to evaluate for osseous metastatic disease. The bone scan showed no osseous metastatic disease, but did show intense focal radiotracer accumulation along the left aspect of the urinary bladder. SPECT/CT images localized this uptake to a calcified bladder wall mass corresponding with the biopsy-proven (via cystoscopy) recurrent tumor. This case demonstrates that (a) some tumors may accumulate radionuclide bone tracer, emphasizing the need for careful evaluation of nonosseous structures during bone scan interpretation; (b) SPECT/CT is useful for clarifying potentially confusing findings and preventing misdiagnosis.
authors.affiliation: Department of Nuclear Medicine, Kaiser Permanente Medical Center, Santa Clara, CA, USA. ryan.d.niederkohr@kp.org
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Niederkohr
authors.forename: Edison
authors.initials: E
authors.lastname: Chiu
authors.forename: Jed A
authors.initials: JA
authors.lastname: Katzel
mesh_terms: D001692:Biological Transport; D005260:Female; D006801:Humans; D008875:Middle Aged; D064847:Multimodal Imaging; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives* / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D014571:Urologic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism*; D019459:Urothelium
chemical_list: C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013669:Technetium Tc 99m Medronate