title: Self-nanoemulsifying drug delivery system of glimepiride: design, development, and optimization.
abstract: The objective of the present investigation was to develop and characterize the self-nanoemulsifying drug delivery system (SNEDDS) of glimepiride, a poorly soluble drug. Solubility of glimepiride in various vehicles was determined, and ternary phase diagrams were constructed using a suitable oil, surfactant, and cosurfactant system to find out the efficient self-emulsification system. A three factor, three level Box-Behnken statistical design was employed to explore the main and interaction effect of independent variables, namely X1 (amount of Capmul MCM), X2 (amount of Acrysol K 140), and X3 (amount of Transcutol P). Percent transmittance value (Y1), droplet diameter (Y2), and percent drug released at 5 min (Y3) were the dependent variables. Formulation optimization was carried out to optimize the droplet diameter and percent drug dissolved at 5 min. The batch prepared according to the optimized formulation showed a close agreement between observed and predicted values. Box-Behnken statistical design allowed us to understand the effect of formulation variables on the rapid dissolution of drug from SNEDDS and to optimize the formulation to obtain a rapid drug dissolution at 5 min.
  A self-nanoemulsifying drug delivery system of glimepiride has been design, developed, and optimized. A three factor, three level Box-Behnken statistical design was employed to explore the main and interaction effect of independent variables, namely X1 (amount of Capmul MCM), X2 (amount of Acrysol K 140), and X3 (amount of Transcutol P). Percent transmittance value (Y1), droplet diameter (Y2), and percent drug released at 5 min (Y3) were the dependent variables. The Capmul MCM-Akcrysol K 140-Transcutol system was found to be the suitable ternary system that was able to release almost 80% of drug within the first 5 min. The improved dissolution of glimepiride might improve patient compliance.
authors.affiliation: Bhagvanlal Kapoorchand Mody Government Pharmacy College, Rajkot, Gujarat, India.
authors.forename: Sunny R
authors.initials: SR
authors.lastname: Shah
authors.forename: Rajesh H
authors.initials: RH
authors.lastname: Parikh
authors.forename: Jayant R
authors.initials: JR
authors.lastname: Chavda
authors.forename: Navin R
authors.initials: NR
authors.lastname: Sheth
mesh_terms: D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D004655:Emulsions; D006801:Humans; D010316:Particle Size; D012995:Solubility; D013501:Surface-Active Agents
chemical_list: D004655:Emulsions; D013501:Surface-Active Agents
keywords: Box-Behnken experimental design; Glimepiride; Self-nanoemulsifying drug delivery system