title: Malignant solitary fibrous tumor involving the liver.
abstract: Solitary fibrous tumors are predominantly benign and are most commonly found in the thoracic cavity and pleura; while reports exist in the literature of malignant solitary fibrous tumors and those located in extrathoracic organs, these cases are considered extremely rare. Herein, a case is reported of a malignant solitary fibrous tumor involving the liver that was diagnosed and treated in a 62-year-old woman. The patient presented with complaints of upper abdominal pain and unintentional weight loss. Computed tomography scan of the abdomen revealed a remarkably large mass, measuring 15 cm × 10 cm × 20 cm, which appeared to be unrelated to any particular organ. The intraoperative finding of a wide communication with the left liver suggested hepatic origin, and served as an indicator for tumor resection via left hemihepatectomy. The diagnosis of solitary fibrous tumor and its malignant nature was confirmed by histological and immunohistochemical examination of the resected tissues. Hepatic solitary fibrous tumor is very rare, and surgery remains the mainstay of treatment. Due to limited reports of such tumors in the literature, little can be said about the benefit of adjuvant therapy and prognosis for the rare cases with malignant histological findings.
authors.affiliation: Department of Surgery, Spitalzentrum Biel AG, CH-2501 Biel, Switzerland.
authors.forename: Manuel
authors.initials: M
authors.lastname: Jakob
authors.forename: Matthias
authors.initials: M
authors.lastname: Schneider
authors.forename: Ingo
authors.initials: I
authors.lastname: Hoeller
authors.forename: Urban
authors.initials: U
authors.lastname: Laffer
authors.forename: Reto
authors.initials: R
authors.lastname: Kaderli
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000737:chemistry / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D008875:Middle Aged; D054364:Solitary Fibrous Tumors / Q000737:chemistry / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D014057:Tomography, X-Ray Computed; D015431:Weight Loss
chemical_list: D014408:Biomarkers, Tumor
keywords: Extrathoracic; Liver; Malignant; Mesenchymal neoplasm; Solitary fibrous tumor; Surgical resection