title: Role of dendritic cells in the regulation of antitumor immunity.
abstract: The majority of rodent and human tumors express antigens that can be recognized by T lymphocytes and are infiltrated by immune cells. Although tumor infiltration by T lymphocytes has been associated with a favorable prognosis, the role of dendritic cells (DCs), which may present tumor-associated antigens in an immunogenic or tolerogenic context, remains elusive. Here, we discuss recent observations suggesting that the function of DCs in the tumor microenvironment may impact the spontaneous resistance of neoplasms to chemotherapy as well as treatment outcome.
authors.affiliation: Laboratory of Immunobiology; Department of Molecular Biology; Université Libre de Bruxelles (ULB); Gosselies, Belgium.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Wathelet
authors.forename: Muriel
authors.initials: M
authors.lastname: Moser
keywords: clinical outcome; dendritic cells; immunosuppression; tumor escape; tumor infiltrate