title: Effectiveness of using the Modified Checklist for Autism in Toddlers in two-stage screening of autism spectrum disorder at the 18-month health check-up in Japan.
abstract: To determine whether the Modified Checklist for Autism in Toddlers (M-CHAT) in conjunction with the routine 18-month health check-up identifies Japanese toddlers with autism spectrum disorder (ASD). Two-stage screening using the M-CHAT was conducted with 1,851 children attending the check-up. Final ASD diagnosis was confirmed at age ≥3 years. Screening identified 20/51 children with ASD: 12/20 true positives were developmentally delayed, whereas 16/22 false negatives were high-functioning. Sensitivity was 0.476, specificity 0.986, positive predictive value 0.455, and likelihood ratio 33.4 for children with ASD. With a few modifications, M-CHAT screening successfully detected toddlers with ASD with and without developmental delay and is a promising screening tool to complement existing community surveillance.
authors.affiliation: Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8553, Japan, kamio@ncnp.go.jp.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kamio
authors.forename: Naoko
authors.initials: N
authors.lastname: Inada
authors.forename: Tomonori
authors.initials: T
authors.lastname: Koyama
authors.forename: Eiko
authors.initials: E
authors.lastname: Inokuchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Miho
authors.initials: M
authors.lastname: Kuroda
mesh_terms: D057189:Checklist; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007564:Japan; D008297:Male; D008403:Mass Screening / Q000379:methods*; D012680:Sensitivity and Specificity