title: Spinocerebellar ataxia type 2 neurodegeneration differentially affects error-based and strategic-based visuomotor learning.
abstract: There are different types of visuomotor learning. Among the most studied is motor error-based learning where the sign and magnitude of the error are used to update motor commands. However, there are other instances where individuals show visuomotor learning even if the sign or magnitude of the error is precluded. Studies with patients suggest that the former learning is impaired after cerebellar lesions, while basal ganglia lesions disrupt the latter. Nevertheless, the cerebellar role is not restricted only to error-based learning, but it also contributes to several cognitive processes. Therefore, here, we tested if cerebellar ataxia patients are affected in two tasks, one that depends on error-based learning and the other that prevents the use of error-based learning. Our results showed that cerebellar patients have deficits in both visuomotor tasks; however, while error-based learning tasks deficits correlated with the motor impairments, the motor error-dependent task did not correlate with any motor measure.
authors.affiliation: Facultad de Psicología, Universidad Nacional Autónoma de México, Mexico City, Distrito Federal, Mexico.
authors.forename: Israel
authors.initials: I
authors.lastname: Vaca-Palomares
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Díaz
authors.forename: Roberto
authors.initials: R
authors.lastname: Rodríguez-Labrada
authors.forename: Jacqeline
authors.initials: J
authors.lastname: Medrano-Montero
authors.forename: Yaimé
authors.initials: Y
authors.lastname: Vázquez-Mojena
authors.forename: Luis
authors.initials: L
authors.lastname: Velázquez-Pérez
authors.forename: Juan
authors.initials: J
authors.lastname: Fernandez-Ruiz
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D001479:Basal Ganglia / Q000473:pathology; D005260:Female; D006801:Humans; D007859:Learning Disabilities / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D010468:Perceptual Disorders / Q000209:etiology*; D011597:Psychomotor Performance / Q000502:physiology*; D020754:Spinocerebellar Ataxias / Q000150:complications*; D014794:Visual Fields / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*