title: Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof.
abstract: HCMV infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In this regard, a series of 1-[ω-(phenoxy)alkyl]uracil derivatives were synthesized and examined for antiviral properties. Compounds 17, 20, 24 and 28 were found to exhibit highly specific and promising inhibitory activity against HCMV replication in HEL cell cultures with EC50 values within 5.5-12μM range. Further studies should be undertaken to elucidate the mechanism of action of these compounds and the structure-activity relationship for the linker region.
authors.affiliation: Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia.
authors.forename: Mikhail S
authors.initials: MS
authors.lastname: Novikov
authors.forename: Denis A
authors.initials: DA
authors.lastname: Babkov
authors.forename: Maria P
authors.initials: MP
authors.lastname: Paramonova
authors.forename: Anastasia L
authors.initials: AL
authors.lastname: Khandazhinskaya
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Ozerov
authors.forename: Alexander O
authors.initials: AO
authors.lastname: Chizhov
authors.forename: Graciela
authors.initials: G
authors.lastname: Andrei
authors.forename: Robert
authors.initials: R
authors.lastname: Snoeck
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Seley-Radtke
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects*; D006801:Humans; D011991:Receptors, Virus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014498:Uracil / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D011991:Receptors, Virus; C064084:cytomegalovirus receptor; D014498:Uracil