title: Design and fabrication of uniquely shaped thiol-ene microfibers using a two-stage hydrodynamic focusing design.
abstract: Microfluidic systems have advantages that are just starting to be realized for materials fabrication. In addition to the more common use for fabrication of particles, hydrodynamic focusing has been used to fabricate continuous polymer fibers. We have previously described such a microfluidics system which has the ability to generate fibers with controlled cross-sectional shapes locked in place by in situ photopolymerization. The previous fiber fabrication studies produced relatively simple round or ribbon shapes, demonstrated the use of a variety of polymers, and described the interaction between sheath-core flow-rate ratios used to control the fiber diameter and the impact on possible shapes. These papers documented the fact that no matter what the intended shape, higher flow-rate ratios produced rounder fibers, even in the absence of interfacial tension between the core and sheath fluids. This work describes how to fabricate the next generation of fibers predesigned to have a much more complex geometry, as exemplified by the "double anchor" shape. Critical to production of the pre-specified fibers with complex features was independent control over both the shape and the size of the fabricated microfibers using a two-stage hydrodynamic focusing system. Design and optimization of the channels was performed using finite element simulations and confocal imaging to characterize each of the two stages theoretically and experimentally. The resulting device design was then used to generate thiol-ene fibers with a unique double anchor shape. Finally, proof-of-principle functional experiments demonstrated the ability of the fibers to transport fluids and to interlock laterally.
authors.affiliation: Naval Research Laboratory, 4555 Overlook Ave, SW Washington, DC 20375, USA.
authors.forename: Darryl A
authors.initials: DA
authors.lastname: Boyd
authors.forename: Adam R
authors.initials: AR
authors.lastname: Shields
authors.forename: Peter B
authors.initials: PB
authors.lastname: Howell
authors.forename: Frances S
authors.initials: FS
authors.lastname: Ligler
mesh_terms: D004867:Equipment Design; D057446:Hydrodynamics; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D011108:Polymers; D013438:Sulfhydryl Compounds