title: Mesothelioma and anti-Ma paraneoplastic syndrome; heterogeneity in immunogenic tumours increases.
abstract: We present a patient with opsoclonus and diffuse cerebellar signs who had an anti-Ma2 antibody-associated paraneoplastic syndrome secondary to a sarcomatoid mesothelioma. This case highlights the importance of early tumour detection, instigation of therapeutic measures, and the heterogeneity of underlying malignancies in neurological paraneoplastic syndromes.
authors.affiliation: Department of Neurosciences, Frenchay Hospital, Bristol, UK.
authors.forename: Hilary Anne
authors.initials: HA
authors.lastname: Archer
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Panopoulou
authors.forename: Nidhi
authors.initials: N
authors.lastname: Bhatt
authors.forename: Anthony James
authors.initials: AJ
authors.lastname: Edey
authors.forename: Nicola Jane
authors.initials: NJ
authors.lastname: Giffin
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000378:metabolism; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008654:Mesothelioma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D020361:Paraneoplastic Syndromes, Nervous System / Q000209:etiology* / Q000276:immunology / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; C119249:Ma2 antigen; D009419:Nerve Tissue Proteins
keywords: Cerebellar Disease; Neuroophthalmology; Paraneoplastic Syndrome