title: Progress and prospects in stem cell therapy.
abstract: In the past few years, progress being made in stem cell studies has incontestably led to the hope of developing cell replacement based therapy for diseases deficient in effective treatment by conventional ways. The induced pluripotent stem cells (iPSCs) are of great interest of cell therapy research because of their unrestricted self-renewal and differentiation potentials. Proof of principle studies have successfully demonstrated that iPSCs technology would substantially benefit clinical studies in various areas, including neurological disorders, hematologic diseases, cardiac diseases, liver diseases and etc. On top of this, latest advances of gene editing technologies have vigorously endorsed the possibility of obtaining disease-free autologous cells from patient specific iPSCs. Here in this review, we summarize current progress of stem cell therapy research with special enthusiasm in iPSCs studies. In addition, we compare current gene editing technologies and discuss their potential implications in clinic application in the future.
authors.affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Xiu-ling
authors.initials: XL
authors.lastname: Xu
authors.forename: Fei
authors.initials: F
authors.lastname: Yi
authors.forename: Hui-ze
authors.initials: HZ
authors.lastname: Pan
authors.forename: Shun-lei
authors.initials: SL
authors.lastname: Duan
authors.forename: Zhi-chao
authors.initials: ZC
authors.lastname: Ding
authors.forename: Guo-hong
authors.initials: GH
authors.lastname: Yuan
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
authors.forename: Hai-chen
authors.initials: HC
authors.lastname: Zhang
authors.forename: Guang-hui
authors.initials: GH
authors.lastname: Liu
mesh_terms: D000818:Animals; D020811:Biomedical Technology / Q000379:methods*; D002454:Cell Differentiation / Q000502:physiology; D018390:Gene Targeting / Q000379:methods; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism / Q000637:transplantation*; D057905:Stem Cell Research; D033581:Stem Cell Transplantation / Q000379:methods*