title: Comparative study on the antibacterial activity of some flavonoids and their sulfonic derivatives.
abstract: The antibacterial activity of quercetin, morin, sodium salt of quercetin-5'-sulfonic acid (NaQSA) and sodium salt of morin-5'-sulfonic acid (NaMSA) were tested against six bacterial strains: Escherichia coli (ATCC 25922 and clinical isolates--ESBL), Pseudomonas aeruginosa (ATCC 27853 and clinical isolates--carbapenem resistant), Staphylococcus aureus (ATCC 29213 and clinical isolats- MRSA). The most effective inhibitors against the model strain S. aureus are NaQSA and NaMSA (MIC = 3.9 microg/mL). Among polyhydroxyflavones used in this investigation, morin exhibits the highest antibacterial activity against tested strains. The structure-activity relationship indicates that 2',4'-dihydroxylation of the B ring in the flavanone structure is important for significant antibacterial activity and that substitution of the sulfo group at position 5' on the lateral phenyl ring enhances antistaphylococcal activity of flavonoids.
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, Rzeszów University of Technology, 6 Powstańców Warszawy St., 35-959 Rzeszów, Poland. elawoz@prz.edu.pl
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Woźnicka
authors.forename: Anna
authors.initials: A
authors.lastname: Kuźniar
authors.forename: Dorota
authors.initials: D
authors.lastname: Nowak
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Nykiel
authors.forename: Maria
authors.initials: M
authors.lastname: Kopacz
authors.forename: Jolanta
authors.initials: J
authors.lastname: Gruszecka
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Golec
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000494:pharmacology*; D047309:Flavones
chemical_list: D000900:Anti-Bacterial Agents; D005419:Flavonoids; D011794:Quercetin; D013451:Sulfonic Acids; C576986:morin-5'-sulfonic acid; C502510:quercetin-5'-sulfonic acid; C008548:morin; D047309:Flavones