title: Influence of different modifications of a calcium phosphate cement on resorption and new bone formation: an in vivo study in the minipig.
abstract: Calcium phosphate cements (CPCs) are established in surgery as temporary bone replacement materials. The most common and important class of CPC, transformed into nanocrystalline hydroxyapatite after setting, is characterized by good biocompatibility and osteoconductivity. However, acceleration of remodelling is in the focus of ongoing research. In the present study, the bone healing efficacy of Biocement D (BioD) modified with mineralized collagen alone (BioD/coll) or in combination with osteocalcin (BioD/coll/OC), O-phospho-L-serine (BioD/coll/PS), sodium citrate (BioD/coll/cit), and polylactide (BioD/coll/PL), respectively, was evaluated in a large animal model. Resorption of the bone substitutes and new bone formation were studied in cyst-like jaw defects of minipigs after filling with the unmodified BioD and the modified BioD variants, respectively. Histomorphometric analysis revealed small differences between the different cement types with respect to resorption. However, new bone formation was improved in case of defects repaired with BioD/coll/OC and BioD/coll/PS and slightly improved in case of BioD/coll and BioD/coll/PL.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Universitätsklinikum Carl Gustav Carus and Medical Faculty of Technische Universität Dresden, Fetscherstr. 74, D-01307, Dresden, Germany.
authors.forename: Ninette
authors.initials: N
authors.lastname: Tödtmann
authors.forename: Anja
authors.initials: A
authors.lastname: Lode
authors.forename: Romy
authors.initials: R
authors.lastname: Mann
authors.forename: Ronald
authors.initials: R
authors.lastname: Mai
authors.forename: Günter
authors.initials: G
authors.lastname: Lauer
authors.forename: Kathrin
authors.initials: K
authors.lastname: Wieczorek
authors.forename: Uwe
authors.initials: U
authors.lastname: Eckelt
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry*; D001861:Bone Regeneration; D016723:Bone Remodeling; D018786:Bone Substitutes / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry*; D002417:Cattle; D003094:Collagen / Q000737:chemistry; D017886:Durapatite; D005260:Female; D008422:Materials Testing; D023421:Models, Animal; D015675:Osteocalcin / Q000737:chemistry; D010012:Osteogenesis / Q000187:drug effects; D013552:Swine; D013556:Swine, Miniature
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D015675:Osteocalcin; D003094:Collagen; D017886:Durapatite; C020243:calcium phosphate
keywords: animal model; biodegradation; bone remodeling; calcium phosphate(s); histomorphometry