title: Correlation between interleukin-18 promoter -607C/A polymorphism and susceptibility to ischemic stroke.
abstract: Single nucleotide polymorphisms in the promoter region of interleukin-18 (IL-18), an inflammatory cytokine, have been linked to susceptibility to many diseases, including cancer and immune dysfunction. Here, we explored the potential association between the IL-18 -607C/A (rs1946518) promoter region polymorphism and susceptibility to ischemic stroke (IS). This locus was amplified from peripheral blood samples of 386 IS patients (cases) and 364 healthy individuals (controls) by the polymerase chain reaction with sequence-specific primers. Significant differences were observed by the χ2 test in the -607C/A (rs1946518) genotype and allele frequencies between cases and controls (P < 0.05). Furthermore, after excluding for age, gender, smoking status, and hypertension, logistic regression indicated that IS susceptibility of -607C carriers increased 1.6 times (OR = 1.601, 95%CI = 1.148-2.233, P = 0.006) compared to -607A carriers. Additionally, similar increases in IS risk were noted for male patients or patients less than 65 years old. In conclusion, IL-18 -607C/A (rs1946518) promoter polymorphism is associated with IS susceptibility, and the C allele may confer increased IS risk.
authors.affiliation: Yancheng Health Vocational and Technical College, Department of Medical Technology, Yancheng City, Jiangsu Province, China. jianxialu2006@126.com
authors.forename: Jian-xia
authors.initials: JX
authors.lastname: Lu
authors.forename: Zhong-qian
authors.initials: ZQ
authors.lastname: Lu
authors.forename: Shao-lan
authors.initials: SL
authors.lastname: Zhang
authors.forename: Juan
authors.initials: J
authors.lastname: Zhi
authors.forename: Zheng-ping
authors.initials: ZP
authors.lastname: Chen
authors.forename: Wan-xiang
authors.initials: WX
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011446:Prospective Studies; D012907:Smoking; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*
chemical_list: D020382:Interleukin-18