title: A meta-analysis of the association between glutathione S-transferase P1 gene polymorphism and the risk of adenocarcinomas of lung cancer.
abstract: BACKGROUND
  Results of the published reports on the relationship between glutathione S-transferase P1 (GSTP1) gene polymorphism and the adenocarcinomas of lung cancer are still debated.
  
  
  OBJECTIVE
  This meta-analysis was performed to evaluate the association between GSTP1 A/G gene polymorphism and the risk of adenocarcinomas of lung cancer.
  
  
  METHODS
  The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method.
  
  
  RESULTS
  16 reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and the risk of adenocarcinomas of lung cancer. The G allele and GG genotype were not associated with the susceptibility of risk of adenocarcinomas. Furthermore, in the sensitivity analysis, the results were similar with those from the non-sensitivity analysis.
  
  
  CONCLUSIONS
  GSTP1 G allele or GG genotype is not a biomarker to be associated with the susceptibility of adenocarcinomas of lung cancer.
authors.affiliation: Department of Cardio-Thoracic Surgery, People's Hospital of Beihai, Beihai, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhong
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Gui-Xiong
authors.initials: GX
authors.lastname: Zheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.forename: Jun-Yuan
authors.initials: JY
authors.lastname: Zhang
authors.forename: Bao-Shi
authors.initials: BS
authors.lastname: Zheng
authors.forename: Xu
authors.initials: X
authors.lastname: Feng
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000235:genetics*; D000077192:Adenocarcinoma of Lung; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D051549:Glutathione S-Transferase pi