title: Tendon stem cells: experimental and clinical perspectives in tendon and tendon-bone junction repair.
abstract: Tendon and tendon-bone junction injuries, while heal, have high re-tear rates. Mesenchymal stem cells (MSCs) have great appeal for the promotion of tendon and tendon-bone junction healing because of their high proliferation rate, multi-potency and relative ease of isolation from various tissues. Tendon stem cells have been identified recently and could be an alternative new cell source for tendon and tendon-bone junction repair. In this review, we summarized the in vitro characteristics of tendon stem cells. The evidence supporting the potential use of these cells for tendon and tendon-bone junction repair was presented. In order to therapeutically apply tendon stem cells in the clinical settings, standardization of tendon stem cell culture is essential. Issues relating to the sources, purity, efficacy, safety and delivery of tendon stem cells for tendon and tendon-bone junction repair were summarized and discussed. The direction for future research was suggested.
authors.affiliation: Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, China ; The Hong Kong Jockey Club Sports Medicine and Health Sciences Centre, Faculty of Medicine, The Chinese University of Hong Kong, China ; Program of Stem Cell and Regeneration, School of Biomedical Science, The Chinese University of Hong Kong, China.
authors.forename: Pauline Po Yee
authors.initials: PP
authors.lastname: Lui
authors.forename: On Tik
authors.initials: OT
authors.lastname: Wong
keywords: tendon healing; tendon progenitors; tendon stem cells; tendon-bone junction healing; tissue engineering