title: Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers.
abstract: Microsatellite instability (MSI) is a critical mechanism that drives genetic aberrations in cancer. To identify the entire MS mutation, we performed the first comprehensive genome- and transcriptome-wide analyses of mutations associated with MSI in Korean gastric cancer cell lines and primary tissues. We identified 18,377 MS mutations of five or more repeat nucleotides in coding sequences and untranslated regions of genes, and discovered 139 individual genes whose expression was down-regulated in association with UTR MS mutation. In addition, we found that 90.5% of MS mutations with deletions in gene regions occurred in UTRs. This analysis emphasizes the genetic diversity of MSI-H gastric tumors and provides clues to the mechanistic basis of instability in microsatellite unstable gastric cancers.
authors.affiliation: CHA Cancer Institute, CHA University, Seoul 135-081, Korea.
authors.forename: Kwiyeom
authors.initials: K
authors.lastname: Yoon
authors.forename: Sunghoon
authors.initials: S
authors.lastname: Lee
authors.forename: Tae-Su
authors.initials: TS
authors.lastname: Han
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Moon
authors.forename: Sun Mi
authors.initials: SM
authors.lastname: Yun
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Kong
authors.forename: Sungwoong
authors.initials: S
authors.lastname: Jho
authors.forename: Jinny
authors.initials: J
authors.lastname: Choe
authors.forename: Jieun
authors.initials: J
authors.lastname: Yu
authors.forename: Hyuk-Joon
authors.initials: HJ
authors.lastname: Lee
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Hak-Min
authors.initials: HM
authors.lastname: Kim
authors.forename: So Yeun
authors.initials: SY
authors.lastname: Lee
authors.forename: Jongsun
authors.initials: J
authors.lastname: Park
authors.forename: Woo-Ho
authors.initials: WH
authors.lastname: Kim
authors.forename: Jong
authors.initials: J
authors.lastname: Bhak
authors.forename: Han-Kwang
authors.initials: HK
authors.lastname: Yang
authors.forename: Seong-Jin
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D044466:Asian People / Q000235:genetics*; D045744:Cell Line, Tumor; D016368:Frameshift Mutation; D015972:Gene Expression Regulation, Neoplastic; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D053842:Microsatellite Instability; D018895:Microsatellite Repeats; D009154:Mutation; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D056910:Republic of Korea; D017384:Sequence Deletion; D013274:Stomach Neoplasms / Q000235:genetics*; D059467:Transcriptome; D020506:Untranslated Regions
chemical_list: D020506:Untranslated Regions