title: Preclinical models of antipsychotic drug action.
abstract: One of the main obstacles faced by translational neuroscience is the development of animal models of psychiatric disorders. Behavioural pharmacology studies indicate that psychedelic drugs, such as lysergic acid diethylamide (LSD) and dissociative drugs, such as phencyclidine (PCP), induce in healthy human volunteers psychotic and cognitive symptoms that resemble some of those observed in schizophrenia patients. Serotonin 5-HT2A and metabotropic glutamate 2 receptors have been involved in the mechanism of action of psychedelic and dissociative drugs. Here we review recent advances using LSD-like and PCP-like drugs in rodent models that implicate these receptors in the neurobiology of schizophrenia and its treatment.
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.
authors.forename: José L
authors.initials: JL
authors.lastname: Moreno
authors.forename: Javier
authors.initials: J
authors.lastname: González-Maeso
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D018094:Receptors, Metabotropic Glutamate / Q000187:drug effects / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D012565:Schizophrenic Psychology; D013045:Species Specificity; D057170:Translational Research, Biomedical
chemical_list: D014150:Antipsychotic Agents; D018094:Receptors, Metabotropic Glutamate