title: Palladium-catalyzed arylic/allylic aminations: permutable domino sequences for the synthesis of dihydroquinolines from Morita-Baylis-Hillman adducts.
abstract: An efficient palladium-catalyzed synthesis of 1,2-dihydroquinolines has been developed via the reaction between anilines and Morita-Baylis-Hillman adducts derived from o-bromobenzaldehyde. This new Pd(0)-catalyzed pseudo-domino type I sequence involves a Buchwald-Hartwig arylic amination and an allylic amination. When starting from an o-bromo allylic alcohol, the chronology is arylic amination/allylic arylation. However, the sequence reverses when the reaction is performed on the corresponding o-bromo allylic acetate.
authors.affiliation: UPMC Univ. Paris 06, Sorbonne Universités , Institut Parisien de Chimie Moléculaire (UMR CNRS 7201), case 183, 4 place Jussieu, 75005 Paris, France.
authors.forename: Mélanie M
authors.initials: MM
authors.lastname: Lorion
authors.forename: Danila
authors.initials: D
authors.lastname: Gasperini
authors.forename: Julie
authors.initials: J
authors.lastname: Oble
authors.forename: Giovanni
authors.initials: G
authors.lastname: Poli