title: Impulsive compulsive behaviors in Japanese Parkinson's disease patients and utility of the Japanese version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's disease.
abstract: BACKGROUND
  In order to evaluate impulsive compulsive behaviors (ICBs), such as pathological gambling, compulsive sexual behavior, compulsive buying, compulsive eating, punding, and dopamine dysregulation syndrome (DDS) in Japanese Parkinson's disease (PD) patients, we constructed a Japanese version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's disease (J-QUIP) and evaluated the utility of the J-QUIP in Japanese PD patients.
  
  
  METHODS
  J-QUIP was administered to 121 PD patients. Diagnoses of ICBs were made via interview of patients or their caregivers. Subsequently, in order to evaluate risk factors related to these conditions, we evaluated demographic and clinical characteristics, clinical features, and medications utilized.
  
  
  RESULTS
  We were able to administer the J-QUIP to 118 of 121 PD patients (97.5%). Sensitivity and specificity of J-QUIP were similar to that reported for the original version of QUIP. In our study, the actual prevalence of each disorder diagnosed via interview was as follows: pathological gambling (6.5%), compulsive sexual behavior (3.2%), compulsive buying (3.2%), compulsive eating (3.2%), punding (6.5%), and DDS (2.2%). Significantly risk factors for these conditions were younger age (p=0.047), earlier age of disease onset (p=0.015), longer PD duration (p=0.001), total levodopa equivalent dose (p=0.006), and dosage of levodopa (p=0.019).
  
  
  CONCLUSIONS
  We evaluated the prevalence of ICBs in Japanese PD patients along with factors associated with these behaviors via J-QUIP.
authors.affiliation: Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Japan. ken0815@med.tottori-u.ac.jp
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Tanaka
authors.forename: Kenji
authors.initials: K
authors.lastname: Wada-Isoe
authors.forename: Satoko
authors.initials: S
authors.lastname: Nakashita
authors.forename: Mikie
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakashima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D017028:Caregivers / Q000523:psychology; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D005715:Gambling / Q000209:etiology; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000150:complications*; D012016:Reference Values; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D014175:Translating
keywords: Compulsive buying; Compulsive eating; Compulsive sexual behavior; Dopamine dysregulation syndrome; Pathological gambling; Punding