title: Epigenetic therapy in allogeneic hematopoietic stem cell transplantation.
abstract: DNA methylation and other epigenetic phenomena appear to be relevant in the pathogenesis of several malignant disorders. DNA methyltransferases add methyl groups to cytosine-phosphate-guanine (CpG) islandsleading to gene promoter silencing. The DNA methyltransferases inhibitors azacitidine and decitabine have anti-tumor activity against a broad range of malignancies, but have been investigated mostly in myelodysplastic syndrome. In addition, these agents have immunomodulatory effects that are under investigation in the allogeneic stem cell transplantation scenario. Both drugs have been used in the perioperative period of allogeneic transplantations with varying degrees of success. It has been hypothesized that low dose azacitidine may increase the graft-versus-leukemia effect and have a role in the maintenance of remission after allogeneic transplantation for myeloid leukemias. It is also intriguing that this favorable effect might occur while mitigating graft-versus-host disease. Here we present a review of the rapidly growing field of epigenetic manipulation using hypomethylating agents in allogeneic transplantation.
authors.affiliation: The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Qaiser
authors.initials: Q
authors.lastname: Bashir
authors.forename: Basem Magdy
authors.initials: BM
authors.lastname: William
authors.forename: Guillermo
authors.initials: G
authors.lastname: Garcia-Manero
authors.forename: Marcos
authors.initials: M
authors.lastname: de Lima
keywords: Azacitidine; DNA methyltransferase; Epigenesis, genetic; Hematopoietic stem cell transplantation; Immunologic factors; Leukemia, myeloid