title: Emmprin and KSHV: new partners in viral cancer pathogenesis.
abstract: Emmprin (CD147; basigin) is a multifunctional glycoprotein expressed at higher levels by cancer cells and stromal cells in the tumor microenvironment. Through direct effects within tumor cells and promotion of tumor-stroma interactions, emmprin participates in induction of tumor cell invasiveness, angiogenesis, metastasis and chemoresistance. Although its contribution to cancer progression has been widely studied, the role of emmprin in viral oncogenesis still remains largely unclear, and only a small body of available literature implicates emmprin-associated mechanisms in viral pathogenesis and tumorigenesis. We summarize these data in this review, focusing on the role of emmprin in pathogenesis associated with the Kaposi sarcoma-associated herpesvirus (KSHV), a common etiology for cancers arising in the setting of immune suppression. We also discuss future directions for mechanistic studies exploring roles for emmprin in viral cancer pathogenesis.
authors.affiliation: Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Dai
authors.forename: Lihua
authors.initials: L
authors.lastname: Bai
authors.forename: Ying
authors.initials: Y
authors.lastname: Lu
authors.forename: Zengguang
authors.initials: Z
authors.lastname: Xu
authors.forename: Krys
authors.initials: K
authors.lastname: Reiss
authors.forename: Luis
authors.initials: L
authors.lastname: Del Valle
authors.forename: Johnan
authors.initials: J
authors.lastname: Kaleeba
authors.forename: Bryan P
authors.initials: BP
authors.lastname: Toole
authors.forename: Chris
authors.initials: C
authors.lastname: Parsons
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Qin
mesh_terms: D000818:Animals; D051926:Basigin / Q000378:metabolism*; D002465:Cell Movement; D002472:Cell Transformation, Viral; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm; D019288:Herpesvirus 8, Human / Q000472:pathogenicity*; D006801:Humans; D016867:Immunocompromised Host; D009361:Neoplasm Invasiveness; D012514:Sarcoma, Kaposi / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D015398:Signal Transduction
chemical_list: D051926:Basigin
keywords: CD147; Emmprin; KSHV; Kaposi sarcoma; Primary effusion lymphoma