title: Predictive validation of an influenza spread model.
abstract: BACKGROUND
  Modeling plays a critical role in mitigating impacts of seasonal influenza epidemics. Complex simulation models are currently at the forefront of evaluating optimal mitigation strategies at multiple scales and levels of organization. Given their evaluative role, these models remain limited in their ability to predict and forecast future epidemics leading some researchers and public-health practitioners to question their usefulness. The objective of this study is to evaluate the predictive ability of an existing complex simulation model of influenza spread.
  
  
  RESULTS
  We used extensive data on past epidemics to demonstrate the process of predictive validation. This involved generalizing an individual-based model for influenza spread and fitting it to laboratory-confirmed influenza infection data from a single observed epidemic (1998-1999). Next, we used the fitted model and modified two of its parameters based on data on real-world perturbations (vaccination coverage by age group and strain type). Simulating epidemics under these changes allowed us to estimate the deviation/error between the expected epidemic curve under perturbation and observed epidemics taking place from 1999 to 2006. Our model was able to forecast absolute intensity and epidemic peak week several weeks earlier with reasonable reliability and depended on the method of forecasting-static or dynamic.
  
  
  CONCLUSIONS
  Good predictive ability of influenza epidemics is critical for implementing mitigation strategies in an effective and timely manner. Through the process of predictive validation applied to a current complex simulation model of influenza spread, we provided users of the model (e.g. public-health officials and policy-makers) with quantitative metrics and practical recommendations on mitigating impacts of seasonal influenza epidemics. This methodology may be applied to other models of communicable infectious diseases to test and potentially improve their predictive ability.
authors.affiliation: Department of Biology, McGill University, Montreal, Quebec, Canada. ayaz.hyder@yale.edu
authors.forename: Ayaz
authors.initials: A
authors.lastname: Hyder
authors.forename: David L
authors.initials: DL
authors.lastname: Buckeridge
authors.forename: Brian
authors.initials: B
authors.lastname: Leung
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003198:Computer Simulation; D004196:Disease Outbreaks; D005544:Forecasting; D006801:Humans; D007223:Infant; D009980:Influenza A virus / Q000276:immunology / Q000472:pathogenicity; D007252:Influenza Vaccines / Q000008:administration & dosage; D007251:Influenza, Human / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control / Q000635:transmission; D008875:Middle Aged; D015233:Models, Statistical; D011634:Public Health / Q000706:statistics & numerical data / Q000639:trends*; D011792:Quebec / Q000453:epidemiology; D015203:Reproducibility of Results; D013997:Time Factors; D014611:Vaccination
chemical_list: D007252:Influenza Vaccines