title: The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis.
abstract: Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are the most common underlying causes of chronic liver injury. They are associated with a wide spectrum of hepatic disorders including basic steatosis, steatohepatitis, and cirrhosis. The molecular and cellular mechanisms underlying hepatic injury in NAFLD and NASH are still unknown. This review describes the roles of oxidative stress and inflammatory responses in the pathogenesis of NAFLD and its progression to NASH.
authors.affiliation: Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. drfucar@gmail.com
authors.forename: Fatma
authors.initials: F
authors.lastname: Ucar
authors.forename: Sevilay
authors.initials: S
authors.lastname: Sezer
authors.forename: Serpil
authors.initials: S
authors.lastname: Erdogan
authors.forename: Sumeyya
authors.initials: S
authors.lastname: Akyol
authors.forename: Ferah
authors.initials: F
authors.lastname: Armutcu
authors.forename: Omer
authors.initials: O
authors.lastname: Akyol
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D018450:Disease Progression; D005234:Fatty Liver / Q000150:complications / Q000209:etiology*; D006801:Humans; D007501:Iron / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver; D008103:Liver Cirrhosis / Q000209:etiology; D008930:Mitochondria, Liver / Q000502:physiology; D065626:Non-alcoholic Fatty Liver Disease; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species; D007501:Iron