title: [First-trimester cystic hygroma: prenatal diagnosis and fetal outcome].
abstract: OBJECTIVE
  To describe the ultrasonographic (US) and fetal karyotyping data of fetuses with cystic hygroma diagnosed in the first trimester.
  
  
  METHODS
  Maternal and fetal data of 69 consecutive fetal cystic hygroma were analysed between 2002 and 2009.
  
  
  RESULTS
  The mean size of the cystic hygroma was 6.3 mm ± 2.4 mm. US abnormalities were present in 54% of cases (37/69) (essentially hydrops fetalis in 45%), with an unfavourable prognosis (P=0.006). Chromosomal abnormalities were present in 53% of cases (36/68) (including 44% of Down syndrome). The rate of unfavourable outcome of pregnancy was 71% of cases (49/69) and was associated with the oldest mothers (P=0.011). In the chromosomally normal pregnancies, there were 59% (19/32) fetus with no apparently abnormalities. Among these 19 children, 13 have been followed up until an average age of 5 years and a half, the infant development was strictly normal.
  
  
  CONCLUSIONS
  The current results suggest to look for the poor prognosis data: nuchal thickness superior to 6 to 6,5 mm, presence of a hydrops fetalis and/or US abnormalities, fetal karyotyping and/or US evolution of cystic hygroma.
authors.affiliation: Département de gynécologie-obstétrique & médecine de la reproduction, université de Saint-Étienne, Jean-Monnet, CHU de Saint-Étienne, avenue Albert-Raimond, 42023 Saint-Étienne, France.
authors.forename: C
authors.initials: C
authors.lastname: Lajeunesse
authors.affiliation: Département de gynécologie-obstétrique & médecine de la reproduction, université de Saint-Étienne, Jean-Monnet, CHU de Saint-Étienne, avenue Albert-Raimond, 42023 Saint-Étienne, France.
authors.forename: A
authors.initials: A
authors.lastname: Stadler
authors.affiliation: Département de santé publique, université de Saint-Étienne, Jean-Monnet, CHU de Saint-Étienne, 42023 Saint-Étienne, France.
authors.forename: B
authors.initials: B
authors.lastname: Trombert
authors.affiliation: Département de gynécologie-obstétrique & médecine de la reproduction, université de Saint-Étienne, Jean-Monnet, CHU de Saint-Étienne, avenue Albert-Raimond, 42023 Saint-Étienne, France.
authors.forename: M N
authors.initials: MN
authors.lastname: Varlet
authors.affiliation: Département de pédiatrie, université de Saint-Étienne, Jean-Monnet, CHU de Saint-Étienne, 42023 Saint-Étienne, France.
authors.forename: H
authors.initials: H
authors.lastname: Patural
authors.affiliation: Département de génétique, université de Saint-Étienne, Jean-Monnet, CHU de Saint-Étienne, 42023 Saint-Étienne, France.
authors.forename: F
authors.initials: F
authors.lastname: Prieur
authors.affiliation: Département de gynécologie-obstétrique & médecine de la reproduction, université de Saint-Étienne, Jean-Monnet, CHU de Saint-Étienne, avenue Albert-Raimond, 42023 Saint-Étienne, France. Electronic address: chenegautier@yahoo.fr.
authors.forename: G
authors.initials: G
authors.lastname: Chêne
mesh_terms: D000328:Adult; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005260:Female; D005333:Fetus; D006801:Humans; D015160:Hydrops Fetalis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics; D007621:Karyotyping; D018191:Lymphangioma, Cystic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis / Q000379:methods*; D011379:Prognosis; D014463:Ultrasonography
keywords: Cystic hygroma; First trimester; Hygroma cervicale; Hygroma kystique; Hyperclarté nucale; Nuchal translucency; Premier trimestre