title: Preliminary genetic analyses of important musculoskeletal conditions of Thoroughbred racehorses in Hong Kong.
abstract: A retrospective cohort study of important musculoskeletal conditions of Thoroughbred racehorses was conducted using health records generated over a 15 year period (n=5062, 1296 sires). The prevalence of each condition in the study population was: fracture, 13%; osteoarthritis, 10%; suspensory ligament injury, 10%; and tendon injury, 19%. Linear and logistic sire and animal regression models were built to describe the binary occurrence of these musculoskeletal conditions, and to evaluate the significance of possible environmental risk factors. The heritability of each condition was estimated using residual maximum likelihood (REML). Bivariate mixed models were used to generate estimates of genetic correlations between each pair of conditions. Heritability estimates of fracture, osteoarthritis, suspensory ligament and tendon injury were small to moderate (range: 0.01-0.20). Fracture was found to be positively genetically correlated with both osteoarthritis and suspensory ligament injury. These results suggest that there is a significant genetic component involved in the risk of the studied conditions. Due to positive genetic correlations, a reduction in prevalence of one of the correlated conditions may effect a reduction in risk of the other condition.
authors.affiliation: School of Veterinary Medicine, University of Glasgow, 464 Bearsden Road, Glasgow, Scotland G61 1QH, United Kingdom. Electronic address: c.walls.1@research.gla.ac.uk.
authors.forename: Claire E
authors.initials: CE
authors.lastname: Welsh
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Lewis
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Blott
authors.forename: Dominic J
authors.initials: DJ
authors.lastname: Mellor
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Lam
authors.forename: Brian D
authors.initials: BD
authors.lastname: Stewart
authors.forename: Timothy D H
authors.initials: TD
authors.lastname: Parkin
mesh_terms: D000818:Animals; D015331:Cohort Studies; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006734:Horse Diseases / Q000453:epidemiology* / Q000235:genetics*; D006736:Horses; D016013:Likelihood Functions; D016015:Logistic Models; D008297:Male; D009140:Musculoskeletal Diseases / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D015995:Prevalence; D019655:Quantitative Trait, Heritable; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Fracture; Heritability; Musculoskeletal; Thoroughbred