title: Aromatic-aromatic interactions: analysis of π-π interactions in interleukins and TNF proteins.
abstract: Aromatic-aromatic hydrogen bonds are important in many areas of chemistry, biology and materials science. In this study we have analyzed the roles played by the π-π interactions in interleukins (ILs) and tumor necrosis factor (TNF) proteins. Majority of π-π interacting residues are conserved in ILs and TNF proteins. The accessible surface area calculations in these proteins reveal that these interactions might be important in stabilizing the inner core regions of these proteins. In addition to π-π interactions, the aromatic residues also form π-networks in ILs and TNF proteins. The results obtained in the present study indicate that π-π interactions and π-π networks play important roles in the structural stability of ILs and TNF proteins.
authors.affiliation: Bioinformatics Division, School of Biosciences & Technology, VIT University, Vellore-632014, India.
authors.forename: Vaideeswaran
authors.initials: V
authors.lastname: Sivasakthi
authors.forename: Parimelzaghan
authors.initials: P
authors.lastname: Anitha
authors.forename: Kalavathi Murugan
authors.initials: KM
authors.lastname: Kumar
authors.forename: Susmita
authors.initials: S
authors.lastname: Bag
authors.forename: Padmanaban
authors.initials: P
authors.lastname: Senthilvel
authors.forename: Pandian
authors.initials: P
authors.lastname: Lavanya
authors.forename: Rayapadi
authors.initials: R
authors.lastname: Swetha
authors.forename: Anand
authors.initials: A
authors.lastname: Anbarasu
authors.forename: Sudha
authors.initials: S
authors.lastname: Ramaiah
keywords: ILs; TNF proteins; stability; structure; π-network; π-π interactions