title: Morbidity characteristics of patients with congenital insensitivity to pain with anhidrosis (CIPA).
abstract: BACKGROUND
  Congenital insensitivity to pain with anhidrosis (CIPA) is a congenital autonomic sensory neuropathy. In southern Israel, there are many patients with this disease. We here tried to characterize the different infections acquired by children with CIPA.
  
  
  METHODS
  We collected all the available data about CIPA patients in southern Israel in the year 1991-2005, including the lesion types, area in the body where the infection occurs, and the treatment given.
  
  
  RESULTS
  The current study included 30 children with CIPA, out of 44 known CIPA patients in southern Israel (68.2%). A total of 382 different episodes of infections, fever, orthopedic lesions, and jaw and mouth lesions led our patients to our outpatient clinic or resulted in hospitalization.
  
  
  CONCLUSIONS
  We found that children with CIPA mainly have infections of the skin and skeleton, and that the most frequent pathogen is Staphylococcus aureus. We also found that a fair amount of these pathogens are resistant to conventional treatment regimens.
authors.affiliation: Soroka University Medical Center, Beer-Sheva, Israel.
authors.forename: Yariv
authors.initials: Y
authors.lastname: Fruchtman
authors.forename: Zvi H
authors.initials: ZH
authors.lastname: Perry
authors.forename: Jacov
authors.initials: J
authors.lastname: Levy
mesh_terms: D000293:Adolescent; D001170:Arthritis, Infectious / Q000453:epidemiology; D001424:Bacterial Infections / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000453:epidemiology; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007557:Israel / Q000453:epidemiology; D008297:Male; D009017:Morbidity; D016728:Self-Injurious Behavior / Q000453:epidemiology; D012883:Skin Ulcer / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000453:epidemiology*; D009057:Stomatognathic Diseases / Q000453:epidemiology; D014945:Wound Healing