title: Synthesis, antibacterial and antifungal evaluation of novel 1,4-dihydropyridine derivatives.
abstract: 3,5-Diacetyl-1,4-dihydro-2,4,6-trimethylpyridine (I) has been condensed with aromatic aldehydes to give the corresponding cinnamoyl derivatives IIa-e. the behavior of IIc, d towards thiourea, hydroxylamine hydrochloride, hydrazine hydrate and other bifunctional reagents has been investigated. The newly synthesized compounds were screened for their antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and as antifungal reagent. Among all the tested compounds, it was found that compounds IIIa and VIIa, b revealed better activity against the Gram-positive rather than the Gram-negative bacteria.
authors.affiliation: Faculty of Science of Girls, King Khaled University, Abha, Saudi Arabia. hanaaabumelha@yahoo.com
authors.forename: Hanaa
authors.initials: H
authors.lastname: Abu-Melha
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D003512:Cyclohexanones / Q000737:chemistry; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000737:chemistry
chemical_list: C026150:1,2-dicyclohexanedione; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003512:Cyclohexanones; D004095:Dihydropyridines; D010080:Oxazoles; C038806:1,4-dihydropyridine
keywords: 1,4-Dihydropyridines; Antimicrobial activity; Cinnamoyl derivatives