title: Early aggressive macrovascular disease and type 1 diabetes mellitus without chronic complications: a case report.
abstract: BACKGROUND
  Type 1 diabetes (T1DM) is considered to be one of the most significant risk factors for the development of coronary artery disease (CAD). However, the specific risk predictor models for T1DM are subject to many limitations.
  
  
  METHODS
  We report the case of a 42-year-old Caucasian woman presenting with T1DM for 26 years. During her chronic hyperglycemic evolution (mean of HbA1c > 3 percentage points above the superior limit) without microvascular complications, this patient presented with early and aggressive coronary artery disease, despite the lack of classical risk factors for CAD CONCLUSIONS: The rapidly progressive macrovascular disease observed in this case demonstrates the different degrees of aggressiveness and unpredictable clinical evolution observed in some cases. It also confirms the need for a multi-factorial, early and optimized clinical management regime.
authors.forename: Alessandra Saldanha de Mattos
authors.initials: AS
authors.lastname: Matheus
authors.forename: Marília Brito
authors.initials: MB
authors.lastname: Gomes
mesh_terms: D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D014652:Vascular Diseases / Q000150:complications*
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human