title: Digital squamous cell carcinoma in dogs: epidemiological, histological, and immunohistochemical study.
abstract: Squamous cell carcinoma represents 47.4% of all malignant canine digital lesions, but despite its frequency, there are few published studies available. Pathology submission records of 154 cases and follow-up of 49 animals were analyzed. On the 49 cases, histological evaluation was performed of the differentiation degree, mitotic index, presence of emboli, and immunohistochemical expression of vimentin and E-cadherin. The mean (SD) age of affected animals was 10.2 (2.3) years; no sex predisposition was recorded. Beauceron and Briard were 2 new overrepresented breeds. Dark-haired animals comprised 97 of 105 (92%); 94 dogs of 125 (75.2%) belonged to large and giant breeds. The forelimb was affected twice more than the hind limb. Probable metastases were observed in 4 dogs; new tumor development was recorded in 11 of 49 (22.4%). Epidemiologic factors, histological grade, mitotic index, and expression of immunohistochemical markers seemed not to be related to the clinical outcome.
authors.affiliation: Service d'Anatomie Pathologique, VetAgro Sup, Campus Vétérinaire, 1, avenue Bourgelat, 69280 Marcy l'etoile, France. Email: sara.belluco@vetagro-sup.fr.
authors.forename: S
authors.initials: S
authors.lastname: Belluco
authors.forename: E
authors.initials: E
authors.lastname: Brisebard
authors.forename: D
authors.initials: D
authors.lastname: Watrelot
authors.forename: E
authors.initials: E
authors.lastname: Pillet
authors.forename: T
authors.initials: T
authors.lastname: Marchal
authors.forename: F
authors.initials: F
authors.lastname: Ponce
mesh_terms: D000367:Age Factors; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000453:epidemiology* / Q000473:pathology; D004285:Dogs; D005260:Female; D005534:Foot Diseases / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D005552:Forelimb; D006614:Hindlimb; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D060787:Neoplasm Grading / Q000662:veterinary; D011379:Prognosis; D014034:Toes / Q000473:pathology*; D014746:Vimentin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D014746:Vimentin
keywords: digit; dog; epidemiology; histological grading; immunohistochemistry; prognostic factors; squamous cell carcinoma