title: Various cyclization scaffolds by a truly Ugi 4-CR.
abstract: Efficient access to a large chemical space based on new scaffolds with defined 3D conformations and highly variable in the side chains is needed to find novel functional materials. Four heterocyclic scaffolds based on a four component Ugi reaction of α-amino acids, oxo components, isocyanides and primary or secondary amines suitably functionalized are described. A handful of examples are described for each scaffold.
authors.affiliation: University of Pittsburgh, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA.
authors.forename: Mantosh K
authors.initials: MK
authors.lastname: Sinha
authors.forename: Kareem
authors.initials: K
authors.lastname: Khoury
authors.forename: Eberhardt
authors.initials: E
authors.lastname: Herdtweck
authors.forename: Alexander
authors.initials: A
authors.lastname: Dömling
mesh_terms: D000588:Amines / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D000596:Amino Acids; D003486:Cyanides; D007659:Ketones; D011759:Pyrrolidines