title: Antihistaminic drug olopatadine downmodulates T cell chemotaxis toward CXCL10 by reducing CXCR3 expression, F-actin polymerization and calcium influx in patients with alopecia areata.
authors.affiliation: Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan. Electronic address: itoutai@hama-med.ac.jp.
authors.forename: Taisuke
authors.initials: T
authors.lastname: Ito
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Fujiyama
authors.forename: Hideo
authors.initials: H
authors.lastname: Hashizume
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Tokura
mesh_terms: D000199:Actins / Q000378:metabolism; D000506:Alopecia Areata / Q000188:drug therapy* / Q000276:immunology* / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects; D054357:Chemokine CXCL10 / Q000378:metabolism; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003990:Dibenzoxepins / Q000494:pharmacology*; D039563:Histamine H1 Antagonists, Non-Sedating / Q000494:pharmacology*; D006801:Humans; D000069605:Olopatadine Hydrochloride; D054367:Receptors, CXCR3 / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D000199:Actins; C114753:CXCL10 protein, human; C515187:CXCR3 protein, human; D054357:Chemokine CXCL10; D003990:Dibenzoxepins; D039563:Histamine H1 Antagonists, Non-Sedating; D054367:Receptors, CXCR3; D000069605:Olopatadine Hydrochloride
keywords: Alopecia areata; CXCL10; Chemotaxis; Olopatadine chroride; Swarm of bees