title: Single cell detection using a magnetic zigzag nanowire biosensor.
abstract: A magnetic zigzag nanowire device was designed for single cell biosensing. Nanowires with widths of 150, 300, 500, and 800 nm were fabricated on silicon trenches by electron beam lithography, electron beam evaporation, and lift-off processes. Magnetoresistance measurements were performed before and after the attachment of a single magnetic cell to the nanowires to characterize the magnetic signal change due to the influence of the magnetic cell. Magnetoresistance responses were measured in different magnetic field directions, and the results showed that this nanowire device can be used for multi-directional detection. It was observed that the highest switching field variation occurred in a 150 nm wide nanowire when the field was perpendicular to the substrate plane. On the other hand, the highest magnetoresistance ratio variation occurred in a 800 nm wide nanowire also when the field was perpendicular to the substrate plane. Besides, the trench-structured substrate proposed in this study can fix the magnetic cell to the sensor in a fluid environment, and the stray field generated by the corners of the magnetic zigzag nanowires has the function of actively attracting the magnetic cells for detection.
authors.affiliation: Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan.
authors.forename: Hao-Ting
authors.initials: HT
authors.lastname: Huang
authors.forename: Tzong-Rong
authors.initials: TR
authors.lastname: Ger
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Lin
authors.forename: Zung-Hang
authors.initials: ZH
authors.lastname: Wei
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D045744:Cell Line, Tumor; D004867:Equipment Design; D006801:Humans; D008280:Magnetics / Q000295:instrumentation*; D059346:Magnets / Q000737:chemistry; D053770:Nanowires / Q000737:chemistry*; D059010:Single-Cell Analysis / Q000295:instrumentation*