title: Mechanical properties of viruses.
abstract: Structural biology techniques have greatly contributed to unveil the relationships between structure, properties and functions of viruses. In recent years, classic structural approaches are being complemented by single-molecule techniques such as atomic force microscopy and optical tweezers to study physical properties and functions of viral particles that are not accessible to classic structural techniques. Among these features are mechanical properties such as stiffness, intrinsic elasticity, tensile strength and material fatigue. The field of virus mechanics is contributing to materials science by investigating some physical parameters of "soft" biological matter and biological nano-objects. Virus mechanics studies are also starting to unveil the biological implications of physical properties of viruses. Growing evidence indicate that viruses are subjected to internal and external forces, and that they may have adapted to withstand and even use those forces. This chapter describes what is known on the mechanical properties of virus particles, their structural determinants, and possible biological implications, of which several examples are provided.
authors.affiliation: Department of Physics of the Condensed Matter, C03, Facultad de Ciencias, Universidad Autónoma de Madrid, Campus de Cantoblanco, 28049, Madrid, Spain, p.j.depablo@uam.es.
authors.forename: Pedro J
authors.initials: PJ
authors.lastname: de Pablo
authors.forename: Mauricio G
authors.initials: MG
authors.lastname: Mateu
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D006801:Humans; D014780:Viruses / Q000737:chemistry*