title: Transporting and shielding photosensitisers by using water-soluble organometallic cages: a new strategy in drug delivery and photodynamic therapy.
abstract: Skin photosensitivity remains one of the main limitations in photodynamic therapy. In this Concept article a strategy to overcome this limitation is described, in which the photosensitizer is hidden inside the hydrophobic cavity of a water-soluble organometallic cage. The metallacage not only protects the photosensitizer from light, it also facilitates its delivery to cancer cells.
authors.affiliation: Institute of Chemistry, University of Neuchatel, Ave de Bellevaux 51, 2000 Neuchatel, Switzerland. bruno.therrien@unine.ch
authors.forename: Bruno
authors.initials: B
authors.lastname: Therrien
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D002945:Cisplatin / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D056831:Coordination Complexes / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008027:Light; D009369:Neoplasms / Q000188:drug therapy; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity; D010984:Platinum / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D004337:Drug Carriers; D017319:Photosensitizing Agents; D014867:Water; D010984:Platinum; D012428:Ruthenium; D002945:Cisplatin