title: Protein-losing enteropathy associated with collagenous colitis cured by withdrawal of a proton pump inhibitor.
abstract: A 63-year-old woman was admitted with symptoms of watery diarrhea and generalized edema lasting for five months. She had been administered 15 mg/day of lansoprazole. Laboratory findings revealed severe hypoproteinemia with normal liver, renal, thyroid and adrenal functions and no proteinuria. Colonoscopy revealed edematous mucosa, minor diminished vascular transparency and apparent longitudinal linear lacerations. The histopathological findings were compatible with a diagnosis of collagenous colitis (CC). Protein leakage from the colon was identified on (99m)Tc-human serum albumin scintigraphy. The results indicated CC associated with protein-losing enteropathy. Discontinuing lansoprazole ameliorated the watery diarrhea and generalized edema, increased the serum albumin level and improved the hypoproteinemia.
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ozeki
authors.forename: Naotaka
authors.initials: N
authors.lastname: Ogasawara
authors.forename: Shinya
authors.initials: S
authors.lastname: Izawa
authors.forename: Mari
authors.initials: M
authors.lastname: Mizuno
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Yanamoto
authors.forename: Hisatsugu
authors.initials: H
authors.lastname: Noda
authors.forename: Noriko
authors.initials: N
authors.lastname: Okaniwa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tanabe
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.forename: Kunio
authors.initials: K
authors.lastname: Kasugai
mesh_terms: D046729:Colitis, Collagenous / Q000139:chemically induced* / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D011504:Protein-Losing Enteropathies / Q000139:chemically induced* / Q000175:diagnosis* / Q000628:therapy; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D028761:Withholding Treatment
chemical_list: D054328:Proton Pump Inhibitors