title: A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO).
abstract: A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new (99m)Tc or (188/186)Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac-[ReBr(CO)3(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Piccinonna
authors.forename: Nicola
authors.initials: N
authors.lastname: Margiotta
authors.forename: Nunzio
authors.initials: N
authors.lastname: Denora
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Iacobazzi
authors.forename: Concetta
authors.initials: C
authors.lastname: Pacifico
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Trapani
authors.forename: Giovanni
authors.initials: G
authors.lastname: Natile
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D007093:Imidazoles / Q000737:chemistry; D008024:Ligands; D011725:Pyridines / Q000737:chemistry; D011868:Radioisotopes / Q000737:chemistry / Q000494:pharmacology*; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D012211:Rhenium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D002352:Carrier Proteins; D056831:Coordination Complexes; D007093:Imidazoles; D008024:Ligands; D011725:Pyridines; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D011963:Receptors, GABA-A; C069997:Tspo protein, rat; D012211:Rhenium