title: [Estimated glucose disposal rate in patients under 18 years of age with type 1 diabetes mellitus and overweight or obesity].
abstract: OBJECTIVE
  To assess the estimated glucose disposal rate (eGDR), insulin dose, and lipoprotein profile in children with type 1 diabetes mellitus (T1DM) and overweight or obesity as compared to children with T1DM and normal weight.
  
  
  METHODS
  A total of 115 patients (aged 5-16 years) with T1DM on intensive insulin therapy were recruited. The following parameters were measured: weight, height, body mass index, waist and hip circumference, insulin dose, eGDR, glycosylated hemoglobin, blood pressure, and lipoprotein profile. Results were stratified by sex and age.
  
  
  RESULTS
  No significant differences were found in eGDR between children with normal weight, overweight, and obesity. However, obese children older than 11 years had lower eGDR values (9.3±1.3 vs 10.1±0.8 mg kg(-1)min(-1); p<0.01). Insulin dose was higher in overweight and obese children, especially in IU/m2/day (37.7 vs 36.1 vs. 29.4 respectively; p<0.01). Obese children had higher low-density lipoprotein cholesterol levels than children with overweight and normal weight (106.5 vs 91.7 vs 91.5mg/dL respectively; p<0.01). No correlation was found between waist circumference and the different markers of insulin resistance.
  
  
  CONCLUSIONS
  Values of eGDR values were lower in obese children with T1DM older than 11 years, and this may therefore be considered a marker of insulin resistance. Insulin dose was higher in diabetic patients with overweight or obesity, specially in IU/m2/day. Obese children with T1DM had a lipoprotein profile of cardiovascular risk.
authors.affiliation: Unidad de Endocrinología Pediátrica, Hospital General Universitario de Ciudad Real, Ciudad Real, España. palomo.enrique@gmail.com
authors.forename: Enrique
authors.initials: E
authors.lastname: Palomo Atance
authors.forename: M José
authors.initials: MJ
authors.lastname: Ballester Herrera
authors.forename: Patricio
authors.initials: P
authors.lastname: Giralt Muiña
authors.forename: Rafael
authors.initials: R
authors.lastname: Ruiz Cano
authors.forename: Alberto
authors.initials: A
authors.lastname: León Martín
authors.forename: Juan
authors.initials: J
authors.lastname: Giralt Muiña
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D001794:Blood Pressure; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000150:complications; D007328:Insulin / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000378:metabolism; D050177:Overweight / Q000150:complications / Q000378:metabolism*; D011446:Prospective Studies; D012494:Sampling Studies; D049629:Waist-Hip Ratio
chemical_list: D005947:Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D008055:Lipids; D008074:Lipoproteins
keywords: Diabetes mellitus; Insulin resistance; Metabolic syndrome; Overweight; Pediatrics; Pediatría; Resistencia a la insulina; Sobrepeso; Síndrome metabólico