title: The effects of hematological parameters and tumor-infiltrating lymphocytes on prognosis in patients with gastric cancer.
abstract: BACKGROUND
  It is well known that tumor-infiltrating lymphocytes (TIL) and, to a lesser extent, peripheral hematologic parameters from patients with cancer have to effect on prognosis. The aim of this study was to evaluate the effect of hematologic parameters and TIL on prognosis of patients with gastric cancer.
  
  
  METHODS
  236 patients who had diagnosed as gastric adenocarcinoma. All hematologic parameters were noted at the time of diagnosis. The number of lymphocyte aggregates as well as the number of lymphocytes within these agregat was counted.The prognostic significance and correlations of high neutrophil-lymphocyte ratio (NLR) together with TIL, was evaluated by multivaried analysis.
  
  
  RESULTS
  The cut-off values of NLR and derived NLR (dNLR) were 3.8 and 2. The NLR was independently associated with survival (P < 0.001). dNLR was not independently associated with overall survival. No significant advantages for overall survival were found for the high TIL (p: 0.372). It was not determined correlation between TIL - NLR and TIL-lymphoid aggregate density (respectivly, P: 0.104; P: 0.246).
  
  
  CONCLUSIONS
  The results suggest that the elevated NLR predicts poor overall survival following at the time diagnosis for all stage gastric cancer. dNLR was not independently associated with overall survival. There is insufficient evidence to the assesment of TIL by a nonspesific method. Therefore further studies is required, to confirm our hypothesis in larger patient cohorts.
authors.affiliation: Medical Oncology Clinic, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey. ahmetdirican@yahoo.com
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dirican
authors.forename: Nese
authors.initials: N
authors.lastname: Ekinci
authors.forename: Arzu
authors.initials: A
authors.lastname: Avci
authors.forename: Murat
authors.initials: M
authors.lastname: Akyol
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alacacioglu
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Kucukzeybek
authors.forename: Isil
authors.initials: I
authors.lastname: Somali
authors.forename: Cigdem
authors.initials: C
authors.lastname: Erten
authors.forename: Lutfiye
authors.initials: L
authors.lastname: Demir
authors.forename: Alper
authors.initials: A
authors.lastname: Can
authors.forename: Ibrahim Vedat
authors.initials: IV
authors.lastname: Bayoglu
authors.forename: Betul
authors.initials: B
authors.lastname: Koyuncu
authors.forename: Eda
authors.initials: E
authors.lastname: Ulger
authors.forename: Mustafa Oktay
authors.initials: MO
authors.lastname: Tarhan
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000276:immunology / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology / Q000473:pathology; D011379:Prognosis; D013274:Stomach Neoplasms / Q000097:blood* / Q000276:immunology* / Q000473:pathology; D016019:Survival Analysis