title: Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review.
abstract: We present here the case of a 66 year old man with a severe bilateral community acquired pneumonia secondary to dissemination after an intravesical instillation of bacilllus Calmette-Guerin (BCG). Diagnosis was based on positive polymerase chain reaction (PCR) for mycobacterium tuberculosis complex in bronchoalveolar lavage and on the finding on transbronchial biopsy of non necrotising granulomas histopathologically similar to the granulomas found in bladder biopsies. These findings were confirmed using a validated real time PCR assay demonstrating the presence of the BCG genome in transbronchial and bladder biopsies.
authors.affiliation: Sezione di Malattie dell'Apparato Respiratorio, Centro per lo Studio delle Malattie Infiammatorie Croniche delle Vie Aeree e Patologie Fumo Correlate dell'Apparato Respiratorio (CEMICEF), Dipartimento di Scienze Mediche, University of Ferrara, Italy. gaetano.caramori@unife.it
authors.forename: G
authors.initials: G
authors.lastname: Caramori
authors.forename: D
authors.initials: D
authors.lastname: Artioli
authors.forename: G
authors.initials: G
authors.lastname: Ferrara
authors.forename: R
authors.initials: R
authors.lastname: Cazzuffi
authors.forename: C
authors.initials: C
authors.lastname: Pasquini
authors.forename: M
authors.initials: M
authors.lastname: Libanore
authors.forename: V
authors.initials: V
authors.lastname: Guardigni
authors.forename: I
authors.initials: I
authors.lastname: Guzzinati
authors.forename: M
authors.initials: M
authors.lastname: Contoli
authors.forename: R
authors.initials: R
authors.lastname: Rossi
authors.forename: R
authors.initials: R
authors.lastname: Rinaldi
authors.forename: C
authors.initials: C
authors.lastname: Contini
authors.forename: A
authors.initials: A
authors.lastname: Papi
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D017714:Community-Acquired Infections / Q000209:etiology*; D006801:Humans; D008297:Male; D018410:Pneumonia, Bacterial / Q000209:etiology*; D001749:Urinary Bladder Neoplasms / Q000628:therapy*
chemical_list: D001500:BCG Vaccine