title: IGF2 gene polymorphisms and IGF-II concentration are determinants of longitudinal weight trends in type 2 diabetes.
abstract: The hypothesis of the study was that IGF2 gene polymorphisms were associated with longitudinal trends in weight through modification of IGF-II concentration.Observational study that explored associations of the IGF2 gene and baseline circulating IGF-II concentration with 'real-world' longitudinal trends in body-mass index in a type 2 diabetes population.26 haplotype tagging single nucleotide polymorphisms (SNPs) from the IGF2 and H19 genes were studied in 485 Caucasian individuals in the Salford Longitudinal Diabetes Cohort. A generalised-estimating equation (GEE) model was used to separately study the association of SNPs and IGF-II concentration with 8-year longitudinal trends in body-mass index.High serum IGF-II concentration at baseline was associated with weight loss over the study period (β=-0.006, 95% CI -0.009 to -0.002, p<0.001). 8 SNPs were associated with longitudinal body-mass index trends, of which 4 retained significance after multiple -testing correction. 2 SNPs rs10770063 and rs3842767 were associated with both IGF-II concentration as well as longitudinal weight changes.We report novel associations between polymorphisms in the IGF2 gene, with concentration of circulating IGF-II and also with longitudinal weight change in type 2 diabetes. Our data indicate that the IGF2 gene and its gene product may be important determinants of longitudinal weight trends in type 2 diabetes.
authors.affiliation: Vascular Research Group. ram.narayanan@manchester.ac.uk
authors.forename: R P
authors.initials: RP
authors.lastname: Narayanan
authors.forename: B
authors.initials: B
authors.lastname: Fu
authors.forename: A
authors.initials: A
authors.lastname: Payton
authors.forename: J E
authors.initials: JE
authors.lastname: Hudson
authors.forename: R L
authors.initials: RL
authors.lastname: Oliver
authors.forename: S G
authors.initials: SG
authors.lastname: Anderson
authors.forename: K W
authors.initials: KW
authors.lastname: Siddals
authors.forename: A
authors.initials: A
authors.lastname: White
authors.forename: W E R
authors.initials: WE
authors.lastname: Ollier
authors.forename: A H
authors.initials: AH
authors.lastname: Heald
authors.forename: J M
authors.initials: JM
authors.lastname: Gibson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C035170:IGF2 protein, human; D007335:Insulin-Like Growth Factor II