title: Synthesis, spectral and antimicrobial activity of Zn(II) complexes with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde/2-hydroxyacetophenone/indoline-2,3-dione.
abstract: Zn(II) complexes have been synthesized by reacting zinc acetate with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/benzaldehyde/indoline-2,3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non electrolytes. Elemental analyses suggest that the complexes have 1:2 metal to ligands stoichiometry of the types [ZnL2(H2O)2](L=monoanionic Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/indoline-2,3-dione) [ZnL2(')(OOCCH3)2(H2O)2](L'=neutral Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde), and they were characterized by IR, (1)H NMR, and (13)C NMR. Particle sizes of synthesized compounds were measured with dynamic light scattering (DLS) analyser which indicates that particle diameter are of the range ca. 100-200nm. All these Schiff bases and their complexes have also been screened for their antibacterial (Bacillus subtilis (B. subtilis), Escherichia coli (E. coli) and antifungal activities (Colletotrichum falcatum (C. falcatum), Aspergillus niger (A. niger), Fusarium oxysporium (F. oxysporium) Curvularia pallescence (C. pallescence). The antimicrobial activities have shown that upon complexation the activity increases.
authors.affiliation: Department of Chemistry, DDU Gorakhpur University, Gorakhpur 273 009, India.
authors.forename: Ajay K
authors.initials: AK
authors.lastname: Singh
authors.forename: O P
authors.initials: OP
authors.lastname: Pandey
authors.forename: S K
authors.initials: SK
authors.lastname: Sengupta
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001547:Benzaldehydes / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000737:chemistry; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D012542:Scattering, Radiation; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D013830:Thiadiazoles / Q000737:chemistry*; D014961:X-Ray Diffraction; D015032:Zinc / Q000494:pharmacology*
chemical_list: D000098:Acetophenones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D001547:Benzaldehydes; D056831:Coordination Complexes; D007211:Indoles; D012545:Schiff Bases; D013830:Thiadiazoles; C572590:indoline-2,3-dione; C058949:1,3,4-thiadiazole; C087908:2'-hydroxyacetophenone; D015032:Zinc; C032175:benzaldehyde
keywords: Antibacterial; Antifungal; DLS analysis; Schiff bases; Zn(II) complexes