title: Epidemiological survey and risk factor analysis of fatty liver disease of adult residents, Beijing, China.
abstract: OBJECTIVE
  With the changes in diet structure and lifestyle, the incidence of fatty liver disease is increasing in China, especially in cities. The goal of the present study was to accurately determine the prevalence and risk factors of fatty liver disease in Beijing residents, China.
  
  
  METHODS
  By using random multistage stratification and cluster sampling, residents aged > 20 years in Dongcheng District and Tongzhou District were recruited, and questionnaire survey, physical examination, detection of fasting glucose, blood lipids and liver biochemistry, and ultrasonography of the liver, gallbladder, and spleen were carried out. Database EpiData 3.0 was employed for data input, followed by statistical analysis with SPSS version 11.0.
  
  
  RESULTS
  A total of 3762 residents were included in the present study including 2328 males and 1434 females with a mean age of 46.37 ± 14.28 years (range 20-92 years). Ultrasonography revealed fatty liver in 1486 residents with a prevalence of 39.5%. Moreover, non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease were found in 1177 (31.3%) and 309 (8.2%) residents, respectively. After adjustment of prevalence based on the age and gender constituents of Beijing residents, the standardized prevalence of overall fatty liver disease, NAFLD, and alcoholic fatty liver disease was 35.1%, 31.0%, and 4.1%, respectively. Binary logistic regression analysis revealed waist-to-hip ratio, diastolic pressure, fasting blood glucose, triglyceride, high-density lipoprotein cholesterol, and low density lipoprotein cholesterol were closely related to NAFLD.
  
  
  CONCLUSIONS
  The Beijing residents have a high prevalence of fatty liver disease as much as 35.1%, which is characterized by NAFLD. Obesity, and glucose and lipid metabolism disorders are the main risk factors of fatty liver disease.
authors.affiliation: Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yan
authors.forename: Wen
authors.initials: W
authors.lastname: Xie
authors.forename: Wei-ni
authors.initials: WN
authors.lastname: Ou
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Su-yun
authors.initials: SY
authors.lastname: Wang
authors.forename: Jian-hui
authors.initials: JH
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Yu-ying
authors.initials: YY
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Feng
authors.forename: Jun
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D002681:China / Q000453:epidemiology; D004032:Diet; D005215:Fasting / Q000097:blood; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology*; D005235:Fatty Liver, Alcoholic / Q000453:epidemiology; D005260:Female; D044882:Glucose Metabolism Disorders / Q000097:blood / Q000150:complications*; D006801:Humans; D008019:Life Style; D052439:Lipid Metabolism Disorders / Q000097:blood / Q000150:complications*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000150:complications*; D015995:Prevalence; D012044:Regression Analysis; D012737:Sex Factors; D011795:Surveys and Questionnaires; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008055:Lipids
keywords: NAFLD; clinical < Hepatology; pathogenesis < Hepatology; steatosis < Hepatology