title: Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase.
abstract: Biocatalytic propane production: structure-based engineering of aldehyde-deformylating oxygenase improves specificity for short- and medium-chain-length aldehydes and enhances the propane generation in whole-cell biotransformations. This presents new opportunities for developing biocatalytic modules for the production of volatile "drop-in" biofuels.
authors.affiliation: Manchester Institute of Biotechnology and Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.
authors.forename: Basile
authors.initials: B
authors.lastname: Khara
authors.forename: Navya
authors.initials: N
authors.lastname: Menon
authors.forename: Colin
authors.initials: C
authors.lastname: Levy
authors.forename: David
authors.initials: D
authors.lastname: Mansell
authors.forename: Debasis
authors.initials: D
authors.lastname: Das
authors.forename: E Neil G
authors.initials: EN
authors.lastname: Marsh
authors.forename: David
authors.initials: D
authors.lastname: Leys
authors.forename: Nigel S
authors.initials: NS
authors.lastname: Scrutton
mesh_terms: D000446:Aldehyde-Lyases / Q000737:chemistry*; D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D055162:Biocatalysis; D056804:Biofuels; D008024:Ligands; D011407:Propane / Q000138:chemical synthesis* / Q000737:chemistry; D013379:Substrate Specificity
chemical_list: D000447:Aldehydes; D000473:Alkanes; D056804:Biofuels; D008024:Ligands; D000446:Aldehyde-Lyases; C043439:aldehyde decarbonylase; D011407:Propane
keywords: aldehyde decarbonylase; biofuels; decarbonylation; enzyme catalysis; specificity