title: [Chemical change of chuanxiong raw materials during storage].
abstract: OBJECTIVE
  To evaluate the chemical changes in Chuanxiong raw material (CX), the rhizome of Ligusticum chuanxiong Hort., during CX storage and further assess its quality variety.
  
  
  METHODS
  Four CX samples were sealed and stored at ambient temperature in room for two years. These samples were quantified on the amounts of characteristic chemical compounds by HPLC-DAD-(APCI) MS techniques.
  
  
  RESULTS
  Eight characteristic peaks in HPLC fingerprint were found to be good separation and assigned as vanillin (1), ferulic acid (2), senkyunolide I (3), senkyunolide H (4), coniferyl ferulate (5), senkyunolide A (6), Z-ligustilide (7) and levistolide A(8), respectively based on their on-line APCI-MS data and UV spectra. After CX being stored, compounds 1 - 4, and 8 were decreased by 44.4%, 52.1%, 37.6%, 52.8% and 47.5% (n = 4), respectively, whilst compounds 5 - 7 were increased by 59.1%, 40.1% and 47.5% (n = 4), respectively.
  
  
  CONCLUSIONS
  Multiple chemical compounds are found to be changed during CX storage, which results in the variety of quality and therapeutic effect because most of the tested compounds have been demonstrated to be bioactive by pharmacological study and clinical trials. It is suggested that CX should be stored under dark, cool and dry condition.
authors.affiliation: Key Laboratory of the Ministry of Education in China on the Standardization of Chinese Materia Medica, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. 381861550@qq.com
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Jin
authors.forename: Guang-Hua
authors.initials: GH
authors.lastname: Lu
authors.forename: Bo-Ping
authors.initials: BP
authors.lastname: Wei
authors.forename: Yuan-Linh
authors.initials: YL
authors.lastname: Hong
authors.forename: Jian-Rui
authors.initials: JR
authors.lastname: Li
authors.forename: Xi
authors.initials: X
authors.lastname: Li
mesh_terms: D001547:Benzaldehydes / Q000032:analysis*; D001572:Benzofurans / Q000032:analysis; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003373:Coumaric Acids / Q000032:analysis; D004356:Drug Storage; D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000737:chemistry; D030004:Ligusticum / Q000737:chemistry*; D011786:Quality Control; D027343:Rhizome / Q000737:chemistry*
chemical_list: D001547:Benzaldehydes; D001572:Benzofurans; D003373:Coumaric Acids; D004365:Drugs, Chinese Herbal; C044571:coniferyl ferulate; C004999:ferulic acid; C100058:vanillin