title: Photoresponsive coumarin-tethered multifunctional magnetic nanoparticles for release of anticancer drug.
abstract: Recently, photoresponsive nanoparticles have received significant attention because of their ability to provide spatial and temporal control over the drug release. In the present work, we report for the first time photoresponsive multifunctional magnetic nanoparticles (MNPs) fabricated using coumarin-based phototrigger and Fe/Si MNPs for controlled delivery of anticancer drug chlorambucil. Further, newly fabricated photoresponsive multifunctional MNPs were also explored for cell luminescence imaging. In vitro biological studies revealed that coumarin tethered Fe/Si MNPs of ~9 nm size efficiently delivered the anticancer drug chlorambucil into cancer cells and thereby improving the drug action to kill the cancer cells upon irradiation. Such multifunctional MNPs with strong fluorescence, good biocompatibility and efficient photocontrolled drug release ability will be of great benefit in the construction of light-activated multifunctional nano drug delivery systems.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
authors.forename: S
authors.initials: S
authors.lastname: Karthik
authors.forename: Nagaprasad
authors.initials: N
authors.lastname: Puvvada
authors.forename: B N Prashanth
authors.initials: BN
authors.lastname: Kumar
authors.forename: Shashi
authors.initials: S
authors.lastname: Rajput
authors.forename: Amita
authors.initials: A
authors.lastname: Pathak
authors.forename: Mahitosh
authors.initials: M
authors.lastname: Mandal
authors.forename: N D Pradeep
authors.initials: ND
authors.lastname: Singh
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry / Q000493:pharmacokinetics*; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D002699:Chlorambucil / Q000737:chemistry / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006923:Hymecromone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D008027:Light; D060526:Magnetic Fields; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000528:radiation effects; D046529:Microscopy, Electron, Transmission; D055668:Photochemical Processes; D014466:Ultraviolet Rays
chemical_list: D018906:Antineoplastic Agents, Alkylating; D002699:Chlorambucil; D006923:Hymecromone