title: Decision-making in transcatheter aortic valve replacement: the impact of frailty in older adults with aortic stenosis.
abstract: Patients with severe aortic stenosis are commonly elderly and with significant comorbidity. Surgical intervention can improve symptoms and survival in severe aortic stenosis. However, a large proportion of patients do not undergo surgical intervention because they are deemed to be inoperable or too high risk. Over the last decade, transcatheter aortic valve replacement (TAVR) has been developed, providing an effective, less-invasive alternative to open cardiac surgery for inoperable or high-risk patients. The purpose of this review is to provide an overview of risk assessment in TAVR. Specifically, this article reviews the epidemiology of aortic stenosis, describes the risks and benefits of TAVR across multiple outcome measures, explores frailty and other elderly risk factors as metrics for improved risk assessment and discusses the application of improved risk assessment in TAVR decisions.
authors.affiliation: Department of Medicine, Columbia University Medical Center, New York, NY, USA.
authors.forename: Catherine Y
authors.initials: CY
authors.lastname: Wong
authors.forename: Philip
authors.initials: P
authors.lastname: Green
authors.forename: Mathew
authors.initials: M
authors.lastname: Williams
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D006328:Cardiac Catheterization / Q000379:methods*; D003657:Decision Making; D016330:Frail Elderly; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D017063:Outcome Assessment, Health Care; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index