title: Mechanical and structural plasticity.
abstract: Excessive narrowing of the airways due to airway smooth muscle (ASM) contraction is a major cause of asthma exacerbation. ASM is therefore a direct target for many drugs used in asthma therapy. The contractile mechanism of smooth muscle is not entirely clear. A major advance in the field in the last decade was the recognition and appreciation of the unique properties of smooth muscle--mechanical and structural plasticity, characterized by the muscle's ability to rapidly alter the structure of its contractile apparatus and cytoskeleton and adapt to the mechanically dynamic environment of the lung. This article describes a possible mechanism for smooth muscle to adapt and function over a large length range by adding or subtracting contractile units in series spanning the cell length; it also describes a mechanism by which actin-myosin-actin connectivity might be influenced by thin and thick filament lengths, thus altering the muscle response to mechanical perturbation. The new knowledge is extremely useful for our understanding of ASM behavior in the lung and could provide new and more effective targets for drugs aimed at relaxing the muscle or keeping the muscle from excessive shortening in the asthmatic airways.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada. cseow@mrl.ubc.ca
authors.forename: Chun Y
authors.initials: CY
authors.lastname: Seow
authors.forename: Julian
authors.initials: J
authors.lastname: Solway
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D056151:Airway Remodeling / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000502:physiology*; D008954:Models, Biological; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology* / Q000648:ultrastructure; D009210:Myofibrils / Q000502:physiology; D051179:Plakins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D051179:Plakins