title: Risk factors associated with nephrocalcinosis in preterm infants.
abstract: OBJECTIVE
  The objective was to identify the risk factors associated with nephrocalcinosis (NC) in preterm infants.
  
  
  METHODS
  NC was diagnosed by renal sonography at 4 or 8 weeks of life, and 10 infants who had findings of type 3 or 4 NC were classified as the NC group. Various clinical and laboratory factors were compared between NC and control groups.
  
  
  RESULTS
  Serum sodium (Na) on day 1, serum creatinine and fractional excretion of calcium (FeCa) at 1 and 2 weeks, and serum calcium (Ca), fractional excretion of sodium (FeNa), and urine Na on 2 weeks of life were significantly different between the two groups: the NC group showed significantly higher serum creatinine, FeNa, and FeCa than the control group, suggesting a greater decrease in renal function in the NC group. Differences of the laboratory findings disappeared after 4 weeks of life. The strongest risk factor was birth weight.
  
  
  CONCLUSIONS
  A transient decrease in renal function during the first 2 weeks of life was associated with development of NC in preterm very low-birth-weight infants, and the risk of NC increased as birth weight decreased.
authors.affiliation: Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Hyun Seung
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: In Kyung
authors.initials: IK
authors.lastname: Sung
authors.affiliation: Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Soon Ju
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Young Ah
authors.initials: YA
authors.lastname: Youn
authors.affiliation: Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Gye-Yeon
authors.initials: GY
authors.lastname: Lim
authors.affiliation: Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Soo Ah
authors.initials: SA
authors.lastname: Im
authors.affiliation: Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Ku
authors.affiliation: Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Division of Neonatology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Kim
mesh_terms: D001724:Birth Weight; D002118:Calcium / Q000097:blood* / Q000652:urine; D016022:Case-Control Studies; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D009397:Nephrocalcinosis / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D016017:Odds Ratio; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000150:complications / Q000378:metabolism*; D012307:Risk Factors; D012964:Sodium / Q000097:blood* / Q000652:urine; D014463:Ultrasonography
chemical_list: D012964:Sodium; D003404:Creatinine; D002118:Calcium