title: Microwave assisted one pot synthesis of some pyrazole derivatives as a safer anti-inflammatory and analgesic agents.
abstract: A series of pyrazolo[3,4-b]quinolines have been synthesized using one-pot water mediated synthetic route under microwave irradiation involving the condensation of 2-chloroquinoline-3-carbaldehydes with semicarbazide or 2,4-dinitrophenyl hydrazine. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. The pharmacological evaluation showed that the compounds are good at inhibiting edema induced by carrageenan and also showed prominent analgesic activity with lesser GI toxicity as indicated by severity index and LPO values.
authors.affiliation: Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India. drmmalam@gmail.com
authors.forename: Mohammad Mumtaz
authors.initials: MM
authors.lastname: Alam
authors.forename: Akranth
authors.initials: A
authors.lastname: Marella
authors.forename: Mymoona
authors.initials: M
authors.lastname: Akhtar
authors.forename: Asif
authors.initials: A
authors.lastname: Husain
authors.forename: Mohammad Shahar
authors.initials: MS
authors.lastname: Yar
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shaquiquzzaman
authors.forename: Om Prakash
authors.initials: OP
authors.lastname: Tanwar
authors.forename: Rikta
authors.initials: R
authors.lastname: Saha
authors.forename: Suruchi
authors.initials: S
authors.lastname: Khanna
authors.forename: Syed
authors.initials: S
authors.lastname: Shafi
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008872:Microwaves; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011720:Pyrazoles