title: Factors affecting the bioaccessibility of fluoride from seafood products.
abstract: Fluoride is considered important for health because of its beneficial effect on the prevention of dental caries and on bone development in the child population. However, excessive intake has negative effects. The main pathway for exposure is oral, through consumption of drinking water, and some food products. Therefore its bioaccessibility (quantity of the element solubilized during the digestive process) is a parameter to be considered when estimating the risk/benefit associated with this element. The aim of the present study was to evaluate the influence of the digestion phase, gastrointestinal digestion factors (pH, pepsin and bile salt concentrations) and the presence of cations on the bioaccessibility of fluoride from seafood products. The results show that the solubilization of fluoride takes place entirely during the gastric phase. Its bioaccessibility is strongly influenced by conditions that favor the formation of insoluble complexes of fluoride with other elements present in the matrix. The factors that are most influential in reducing its bioaccessibility are the increase in pH in the gastric phase, the presence of cations, especially in the intestinal phase, and a low concentration of bile salts.
authors.affiliation: Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Paterna, Valencia, Spain.
authors.forename: R A
authors.initials: RA
authors.lastname: Rocha
authors.forename: B
authors.initials: B
authors.lastname: de la Fuente
authors.forename: M J
authors.initials: MJ
authors.lastname: Clemente
authors.forename: A
authors.initials: A
authors.lastname: Ruiz
authors.forename: D
authors.initials: D
authors.lastname: Vélez
authors.forename: V
authors.initials: V
authors.lastname: Devesa
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002136:Calcium, Dietary / Q000009:adverse effects / Q000378:metabolism; D004063:Digestion; D005399:Fishes; D005459:Fluorides / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000378:metabolism*; D019266:Iron, Dietary / Q000009:adverse effects / Q000378:metabolism; D019565:Metals, Light / Q000009:adverse effects / Q000378:metabolism; D008954:Models, Biological; D009753:Nutritive Value; D009994:Osmolar Concentration; D033561:Penaeidae / Q000737:chemistry; D010434:Pepsin A / Q000378:metabolism; D017747:Seafood / Q000032:analysis*; D012758:Shellfish / Q000032:analysis*; D012995:Solubility
chemical_list: D001647:Bile Acids and Salts; D002136:Calcium, Dietary; D019266:Iron, Dietary; D019565:Metals, Light; D010434:Pepsin A; D005459:Fluorides
keywords: Bile salts; Bioaccessibility; Cations; Fluoride; Pepsin; TIM; TISAB; TNO intestinal model; pH; total ionic strength adjustment buffer