title: [Expression and significance of survivin and PCNA in sinonasal inverted papilloma].
abstract: OBJECTIVE
  To explore the expression and significance of survivin and proliferating cell nuclear antigen (PCNA) on the occurrence, proliferation, recurrence and carcinogenesis of the sinonasal inverted papilloma (SNIP).
  
  
  METHODS
  Immunohistochemical method was used to detect the expression of survivin and PCNA in 10 cases of nasal cavity mucosal (NM), 45 cases of SNIP and 9 cases of canceration SNIP.
  
  
  RESULTS
  The positive expression of survivin and PCNA increased gradually in NM,SNIP and canceration PCNA group, and there were significant difference between the three groups. But there was no correlation between survivin and PCNA in the tissue of SNIP (r = 0.135, P > 0.05).
  
  
  CONCLUSIONS
  Survivin and PCNA are involved in the growth and carcinogenesis of SNIP.
authors.affiliation: Department of Otolaryngology, the Central Hospital of Handan, Handan, 056000, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Peng
authors.forename: Chunguang
authors.initials: C
authors.lastname: Shan
authors.forename: Zhixing
authors.initials: Z
authors.lastname: Feng
authors.forename: Lihui
authors.initials: L
authors.lastname: Yang
mesh_terms: D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D009669:Nose Neoplasms / Q000378:metabolism* / Q000473:pathology; D018308:Papilloma, Inverted / Q000378:metabolism* / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000378:metabolism* / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D000077022:Survivin
chemical_list: C117749:Birc5 protein, mouse; D051034:Inhibitor of Apoptosis Proteins; D018809:Proliferating Cell Nuclear Antigen; D012097:Repressor Proteins; D000077022:Survivin