title: An observational study of the association between adenovirus 36 antibody status and weight loss among youth.
abstract: OBJECTIVE
  Although the human adenovirus 36 (Ad-36) is associated with obesity and relative hypolipidemia, its role in pediatric weight loss treatment response is uncertain. Therefore, the primary study objective was to determine whether Ad-36 antibody (AB) status was associated with response to a pediatric weight loss program. The secondary objective was to assess the association between Ad-36 AB status and baseline lipid values.
  
  
  METHODS
  Participants included 73 youth aged 10-17 years in a residential camp-based weight loss program. The study examined differences in baseline lipid values between Ad-36 AB+ and AB- youth as well as differences in response to treatment, including indices of body size and fitness.
  
  
  RESULTS
  At baseline, results showed that Ad-36 AB+ youth evidenced significantly lower levels of total cholesterol and triglycerides than Ad-36 AB- youth (all p < 0.05). After 4 weeks of treatment, the Ad-36 AB+ youth showed a smaller reduction in BMI percentile than the Ad-36 AB- youth (p < 0.05), a difference of about 0.48 kg.
  
  
  CONCLUSIONS
  Ad-36 AB status showed a weak association with treatment response, but was associated with a better lipid profile. Ad-36 AB status should be assessed in studies of pediatric obesity treatment and prevention.
authors.affiliation: Department of Psychology, Saint Louis University, St. Louis, MO, USA. vanderjs@slu.edu
authors.forename: Jillon S
authors.initials: JS
authors.lastname: Vander Wal
authors.forename: Jean
authors.initials: J
authors.lastname: Huelsing
authors.forename: Olga
authors.initials: O
authors.lastname: Dubuisson
authors.forename: Nikhil V
authors.initials: NV
authors.lastname: Dhurandhar
mesh_terms: D000260:Adenoviruses, Human / Q000276:immunology*; D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D015992:Body Mass Index; D002648:Child; D002784:Cholesterol / Q000097:blood / Q000276:immunology; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood* / Q000276:immunology; D008297:Male; D063766:Pediatric Obesity / Q000097:blood / Q000276:immunology* / Q000628:therapy; D014280:Triglycerides / Q000097:blood / Q000276:immunology; D015431:Weight Loss / Q000276:immunology*; D061217:Weight Reduction Programs
chemical_list: D000914:Antibodies, Viral; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol