title: Expression of phosphatase of regenerating liver-3 (PRL-3) in endometrioid cancer and lymph nodes metastases.
abstract: OBJECTIVE
  We identify the expression of PRL-3 in primary endometrioid endometrial cancer and metastases in relation to the clinicopathological characteristics.
  
  
  METHODS
  The study involved 30 patients with type I endometrial cancer. Twelve of them were diagnosed with metastases in various localization of abdomen. The PRL-3 expression was evaluated on the basis of immunohistochemistry results by the use of monoclonal antibody anti-PRL3 clone 3B6.
  
  
  RESULTS
  The intensity of PRL-3 expression in correlation with tumor stage was statistically significant (p = 0.024). The strongest reaction was noted in cases classified as a 1a and 1b stage defined by FIGO. The strength of PRL-3 expression is significantly associated with the degree of histological tumor grade (p = 0.035).
  
  
  CONCLUSIONS
  The strong expression of PRL-3 in the primary tumor that was significantly correlated with the grade and clinical stage suggest that PTP4A3 participates in the process of endometrial carcinogenesis.
authors.forename: K
authors.initials: K
authors.lastname: Guzińska-Ustymowicz
authors.forename: J
authors.initials: J
authors.lastname: Kiśluk
authors.forename: S J
authors.initials: SJ
authors.lastname: Terlikowski
authors.forename: A
authors.initials: A
authors.lastname: Pryczynicz
authors.forename: K
authors.initials: K
authors.lastname: Niewiarowska
authors.forename: M
authors.initials: M
authors.lastname: Ustymowicz
authors.forename: M
authors.initials: M
authors.lastname: Hawryluk
authors.forename: M
authors.initials: M
authors.lastname: Południewski
authors.forename: A
authors.initials: A
authors.lastname: Kemona
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D018269:Carcinoma, Endometrioid / Q000201:enzymology* / Q000556:secondary; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000201:enzymology / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000276:immunology / Q000378:metabolism*; D009367:Neoplasm Staging; D011379:Prognosis; D017027:Protein Tyrosine Phosphatases / Q000276:immunology / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D009363:Neoplasm Proteins; C484730:PTP4A3 protein, human; D017027:Protein Tyrosine Phosphatases