title: Affinity analysis of differentially expressed genes in hepatocytes expressing HCV core genotype 1b or 3a.
abstract: Chronic hepatitis C patients display many genotype-specific clinical features of HCV infection. The core proteins encoded by different genotypes dysregulate numerous sets of distinct host genes. In this study we tested the hypothesis that HCV core proteins 1b and 3a would actually act on a limited number of independent cellular players, as well as on several functionally linked gene products. Structural and functional tests identified a core set of host genes dysregulated by HCV core genotypes 1b and 3a. The core proteins of HCV genotypes 1b and 3a target specifically limited sets of functionally related gene products, which may be responsible for the variations in the clinical spectra associated with HCV infection.
authors.affiliation: Bioinformatics Unit, IRCCS Casa Sollievo della Sofferenza - Mendel Laboratory, Rome, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Mazza
authors.forename: Stefano
authors.initials: S
authors.lastname: Castellana
authors.forename: Angelo
authors.initials: A
authors.lastname: Andriulli
authors.forename: Charles
authors.initials: C
authors.lastname: Auffray
authors.forename: Manlio
authors.initials: M
authors.lastname: Vinciguerra
authors.forename: Valerio
authors.initials: V
authors.lastname: Pazienza
mesh_terms: D004843:Epistasis, Genetic / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000235:genetics / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D008957:Models, Genetic; D014758:Viral Core Proteins / Q000378:metabolism*
chemical_list: D014758:Viral Core Proteins
keywords: HCV core protein; System biology