title: Photodynamic therapy associated with full-mouth ultrasonic debridement in the treatment of severe chronic periodontitis: a randomized-controlled clinical trial.
abstract: BACKGROUND
  Photodynamic therapy (PDT) is a method of microbial reduction which can benefit periodontal treatment in areas of difficult access, such as deep pockets and furcations. The aim of this randomized controlled clinical trial was to evaluate the effects of PDT as an adjunct to full-mouth ultrasonic debridement in the treatment of severe chronic periodontitis.
  
  
  METHODS
  Twenty-two patients with at least one pocket with a probing depth (PD) of ≥7 mm and one pocket with a PD of ≥5 mm and bleeding on probing (BOP) on each side of the mouth were included, characterizing a split mouth design. The control group underwent full-mouth ultrasonic debridement and the test group received the same treatment associated with PDT. The PDT was performed on only one side of the mouth and the initial step consisted of subgingival irrigation with 0.005% methylene blue dye. Two minutes after applying the photosensitizer, the low power laser - AsGaAl (Photon Lase III - PL7336, DMC, São Carlos - São Paulo, Brazil) was applied (660 nm, 100 mW, 9 J, 90 seconds per site, 320 J/cm², diameter tip 600 µm). The following clinical parameters were evaluated: plaque index, gingival index, BOP, gingival recession (GR), PD, and clinical attachment level (CAL). All parameters were collected before, 1, 3 and 6 months after treatment.
  
  
  RESULTS
  An improvement in BOP, PD and CAL was observed after treatment, in both groups, but without any difference between them. After 6 months, the PD decreased from 5.11±0.56 mm to 2.83±0.47 mm in the test group (p<0.05) and from 5.15±0.46 mm to 2.83±0.40 mm in the control group (p<0.05). The CAL changed, after 6 months, from 5.49±0.76 mm to 3.41±0.84 mm in the test group (p<0.05) and from 5.53±0.54 to 3.39±0.51 mm in the control group (p<0.05).
  
  
  CONCLUSIONS
  Both approaches resulted in significant clinical improvements in the treatment of severe chronic periodontits, however, the PDT did not provide any additional benefit to those obtained with full-mouth ultrasonic debridement used alone.
authors.affiliation: Bahiana School of Medicine and Public Health, Salvador, BA, Brazil.
authors.forename: Maybel Lages
authors.initials: ML
authors.lastname: Balata
authors.forename: Lyla Prates de
authors.initials: LP
authors.lastname: Andrade
authors.forename: David Barros Nunes
authors.initials: DB
authors.lastname: Santos
authors.forename: Andrea Nóbrega
authors.initials: AN
authors.lastname: Cavalcanti
authors.forename: Urbino da Rocha
authors.initials: Uda R
authors.lastname: Tunes
authors.forename: Érica Del Peloso
authors.initials: Édel P
authors.lastname: Ribeiro
authors.forename: Sandro
authors.initials: S
authors.lastname: Bittencourt
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D055113:Chronic Periodontitis / Q000628:therapy*; D003646:Debridement / Q000379:methods*; D012534:Dental Scaling / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010778:Photochemotherapy / Q000379:methods*; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods*