title: A controlled-release nanocarrier with extracellular pH value driven tumor targeting and translocation for drug delivery.
abstract: This pHLIP is no flop: Functionalizing mesoporous silica nanoparticles (MSNs) with pHLIPss peptide provides a controlled-release nanoparticle drug delivery system targeting the acidic tumor microenvironment. At low pH values, pHLIPss inserts into the cell membrane and translocates carriers into cells, where the cargo is released by the cleavage of the pHLIPss disulfide bonds (see scheme).
authors.affiliation: Molecular Science and Biomedicine Laboratory, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082, China.
authors.forename: Zilong
authors.initials: Z
authors.lastname: Zhao
authors.forename: Hongmin
authors.initials: H
authors.lastname: Meng
authors.forename: Nannan
authors.initials: N
authors.lastname: Wang
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Donovan
authors.forename: Ting
authors.initials: T
authors.lastname: Fu
authors.forename: Mingxu
authors.initials: M
authors.lastname: You
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chen
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zhang
authors.forename: Weihong
authors.initials: W
authors.lastname: Tan
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000008:administration & dosage / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy; D010455:Peptides / Q000737:chemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; C509968:MCM-41; D010455:Peptides; D012822:Silicon Dioxide; D004317:Doxorubicin
keywords: drug delivery; mesoporous silica nanoparticle; nanocarriers; pHLIP; targeted release