title: N-Triethylene glycol (N-TEG) as a surrogate for the N-methyl group: application to Sansalvamide A peptide analogs.
abstract: Here we studied the N-triethylene glycol (N-TEG) group as a surrogate for the N-Me group in Sansalvamide A peptide. The five N-TEG and N-Me analogs of this cyclic pentapeptide were synthesized, and their biological activity, lipophilicity and conformational features were compared.
authors.affiliation: Institute for Research in Biomedicine (IRB), Barcelona Science Park (PCB), Baldiri Reixac 10, 08028 Barcelona, Spain.
authors.forename: Ana I
authors.initials: AI
authors.lastname: Fernández-Llamazares
authors.forename: Jesús
authors.initials: J
authors.lastname: García
authors.forename: Vanessa
authors.initials: V
authors.lastname: Soto-Cerrato
authors.forename: Ricardo
authors.initials: R
authors.lastname: Pérez-Tomás
authors.forename: Jan
authors.initials: J
authors.lastname: Spengler
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D047630:Depsipeptides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D047630:Depsipeptides; C119376:sansalvamide A; C028914:triethylene glycol; D011092:Polyethylene Glycols