title: The development of scleromalacia after regional conjunctivectomy with the postoperative application of mitomycin C as an adjuvant therapy.
abstract: A 40-year-old woman presented with ocular discomfort in both eyes that had persisted for several months. Six months ago, she had undergone a bilateral nasal and temporal conjunctivectomy using a bare scleral technique followed by a postoperative application of 0.02% mitomycin C (MMC) to treat her chronic hyperemic conjunctiva for cosmesis. Slit-lamp examination revealed that the patient had bilateral nasal and temporal scleral thinning, and a calcified plaque on her nasal conjunctiva. There was no episcleral tissue present around the wound area, and it was difficult to detect any normal conjunctival tissue in the adjacent area for covering the lesion. We believe that performing an aggressive conjunctival excision procedure followed with MMC application for cosmetic enhancement may be disastrous in certain cases.
authors.affiliation: Department of Ophthalmology and Visual Science, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Hye Young
authors.initials: HY
authors.lastname: Shin
authors.forename: Man Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Sung Kun
authors.initials: SK
authors.lastname: Chung
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D003229:Conjunctival Diseases / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D016685:Mitomycin / Q000009:adverse effects*; D011183:Postoperative Complications / Q000139:chemically induced* / Q000473:pathology; D015422:Scleral Diseases / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin
keywords: Mitomycin C; Regional conjunctivectomy; Scleromalacia