title: Dysembryoplastic neuroepithelial tumor: a clinical, neuroradiological, and pathological study of 15 cases.
abstract: Dysembryoplastic neuroepithelial tumors are rare, surgically curable, neuronal-glial neoplasms affecting young patients with intractable epilepsy. Its recognition is needed to avoid unnecessary adjuvant therapy. The authors reviewed the records of 15 patients with dysembryoplastic neuroepithelial tumors who underwent epilepsy surgery using intraoperative electrocorticography monitoring, including 8 males and 7 females (mean age, 15.8 years). Neuroimaging showed a predominantly intracortical location, the presence of septations, a triangular pattern of distribution, a lack of contrast enhancement, and an absence of peritumoral edema. Eleven cases were classified as complex type, 3 as simple type, and 1 as "nonspecific" type. Associated cortical dysplasia was found in 5 cases and leptomeningeal involvement in 1 case. Its immunophenotype suggested a pluripotential neuroepithelial origin. The mean follow-up was 37.5 months; 2 patients had tumor recurrence. Although they are generally benign neoplasms, recurrences sometimes occur. Complete resection of the tumor with the epileptogenic zone is important for a favorable outcome.
authors.affiliation: Department of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, Henan, People's Republic of China.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Henan University Huaihe Hospital, Kaifeng, Henan, People's Republic of China.
authors.forename: Wen-Zhong
authors.initials: WZ
authors.lastname: Hu
authors.affiliation: Department of Pathology, Henan Provincial People's Hospital, Zhengzhou, Henan, People's Republic of China zhaoruijiao@126.com.
authors.forename: Rui-Jiao
authors.initials: RJ
authors.lastname: Zhao
authors.affiliation: Department of Pathology, Henan Provincial People's Hospital, Zhengzhou, Henan, People's Republic of China.
authors.forename: Ling-Fei
authors.initials: LF
authors.lastname: Kong
mesh_terms: D000293:Adolescent; D000328:Adult; D001929:Brain Edema / Q000503:physiopathology; D001932:Brain Neoplasms / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local; D018302:Neoplasms, Neuroepithelial / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: dysembryoplastic neuroepithelial tumor; immunohistochemistry; recurrence; seizure