title: Pharmacokinetic interaction of enrofloxacin/trimethoprim combination following single-dose intraperitoneal and oral administration in rats.
abstract: The pharmacokinetic interaction of enrofloxacin and trimethoprim was evaluated after single-dose intraperitoneal or oral co-administration in rats. Plasma concentrations of the two drugs were determined by high-performance liquid chromatography. Following intraperitoneal combination, a significant (P < 0.05) increase in mean values of plasma half-life (t 1/2) and maximum plasma concentration (C max) was observed for enrofloxacin and trimethoprim, respectively. There was a significant (P < 0.05) increase in mean values of area under the plasma drug concentration versus time from time zero to infinity (AUC0-∞) and C max between combined oral doses (10, 30 and 100 mg/kg) of both antibacterial drugs. Also, after oral conjugation a significant difference in mean values of MRT0-∞ was observed between lower (10 mg/kg) and higher (100 mg/kg) doses of both drugs. A significant increase in pharmacokinetic parameters of both drugs in combined intraperitoneal and oral doses indicated pharmacokinetic interaction of enrofloxacin and trimethoprim. Further study is recommended in other species of animals.
authors.affiliation: Veterinary Clinical Pharmacology Laboratory, College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, South Korea.
authors.forename: Myung-Jin
authors.initials: MJ
authors.lastname: Choi
authors.forename: Sileshi Belew
authors.initials: SB
authors.lastname: Yohannes
authors.forename: Seung-Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Dereje
authors.initials: D
authors.lastname: Damte
authors.forename: Jong-Choon
authors.initials: JC
authors.lastname: Kim
authors.forename: Joo-Won
authors.initials: JW
authors.lastname: Suh
authors.forename: Seung-Chun
authors.initials: SC
authors.lastname: Park
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004347:Drug Interactions; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D007274:Injections, Intraperitoneal; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D017207:Rats, Sprague-Dawley; D014295:Trimethoprim / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D024841:Fluoroquinolones; C000589207:enrofloxacin-trimethoprim combination; D000077422:Enrofloxacin; D014295:Trimethoprim