title: Supplementation with 1% energy trans fatty acids had little effect on serum cholesterol levels in healthy young Japanese women.
abstract: The World Health Organization (WHO) has recommended that trans fatty acid (TFA) intake should be less than 1% of total energy intake, but few data are available as to the influence of energy TFA intake of as low as 1% on blood cholesterol levels. A randomized, double-blind, parallel trial was conducted to assess the effects of 1% TFA dietary supplementation on serum cholesterol levels in healthy young women. Sixty-five volunteers consumed cookies containing 1% (TFA) or 0.04% (control) energy of TFA for 4 weeks and blood was harvested after overnight fasting. There were no significant differences in serum LDL- or HDL-cholesterol levels between the two groups. The hemoglobin A1c level was not influenced by dietary TFA. These results suggest that energy of TFAs at less than 1% has little effect on serum cholesterol or hemoglobin A1c levels in healthy young women. This confirms the correctness of the WHO recommendation.
authors.affiliation: Department of Food and Nutrition, Toyama College, Toyama, Japan. takeuchi@toyama-c.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Taiki
authors.initials: T
authors.lastname: Kutsuwada
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shirokawa
authors.forename: Sumiko
authors.initials: S
authors.lastname: Harada
authors.forename: Michihiro
authors.initials: M
authors.lastname: Sugano
mesh_terms: D000293:Adolescent; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D019587:Dietary Supplements; D002149:Energy Intake; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007564:Japan; D044242:Trans Fatty Acids / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D044242:Trans Fatty Acids; C517652:hemoglobin A1c protein, human