title: The effects of adjunctive parathyroid hormone injection on bisphosphonate-related osteonecrosis of the jaws: an animal study.
abstract: Bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) is a serious and challenging complication of chronic BP uptake in patients with osteoporosis who require management of skeletal-related events. The efficiency of adjunctive parathyroid hormone (PTH) injection was evaluated after chronic BP administration that was followed by tooth extraction. BRONJ was not observed in any of the subjects in the control groups, while BRONJ was observed in 66% and 22% of the subjects in the tooth extraction group and the tooth extraction with PTH injection group, respectively. In addition the presence and severity of inflammation was lower in the PTH injected group than in the tooth extraction group, but the difference was not statistically significant (P>0.01). In conclusion, the administration of 30μg/kg/day PTH during a period of 8 weeks had positive effects on the resolution of BRONJ, but further studies are required to verify the effectiveness of PTH in the treatment of BRONJ.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Baskent University, Ankara and Konya, Turkey. Electronic address: edayisoylu@gmail.com.
authors.forename: E H
authors.initials: EH
authors.lastname: Dayisoylu
authors.forename: F Ç
authors.initials: FÇ
authors.lastname: Şenel
authors.forename: C
authors.initials: C
authors.lastname: Üngör
authors.forename: E
authors.initials: E
authors.lastname: Tosun
authors.forename: M
authors.initials: M
authors.lastname: Çankaya
authors.forename: S
authors.initials: S
authors.lastname: Ersöz
authors.forename: F
authors.initials: F
authors.lastname: Taskesen
mesh_terms: D000818:Animals; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000188:drug therapy* / Q000209:etiology; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D004195:Disease Models, Animal; D005260:Female; D007093:Imidazoles / Q000009:adverse effects*; D007571:Jaw Diseases / Q000188:drug therapy*; D008334:Mandible / Q000166:cytology / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000139:chemically induced*; D010281:Parathyroid Hormone / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014081:Tooth Extraction; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D010281:Parathyroid Hormone; D000077211:Zoledronic Acid
keywords: animal model; bisphosphonate-related osteonecrosis of the jaw; parathyroid hormone; teriparatide