title: Immunomodulatory and hypoallergenic properties of milk protein hydrolysates in ICR mice.
abstract: Approximately 2.5% of young children are allergic to cow milk. In this study, milk protein hydrolysates made from full-cream milk via enzymatic hydrolysis played a positive role in regulating the immune system of ICR mice. Milk protein hydrolysates enhanced immunity in mice by stimulating host immunity, probably by increasing the weight of certain immune system organs, improving the level of hemolysin in serum, and enhancing the phagocytosis of macrophages. Milk protein hydrolysates have the capability to reduce type I hypersensitivity by decreasing IgE levels, IL-4 in serum, and the release of histamine and bicarbonate in peritoneal mast cells, as well as enhancing transforming growth factor-β levels in the serum of ovalbumin-sensitized mice.
authors.affiliation: Food Science and Technology Department of the Marine Science School, Ningbo University, Ningbo 315211, P R China. daodongpan@163.com
authors.forename: D D
authors.initials: DD
authors.lastname: Pan
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: X Y
authors.initials: XY
authors.lastname: Cao
authors.forename: X Q
authors.initials: XQ
authors.lastname: Zeng
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D006868:Hydrolysis; D007109:Immunity / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008894:Milk Proteins / Q000276:immunology* / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D013154:Spleen / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects; D016212:Transforming Growth Factor beta / Q000097:blood
chemical_list: D007074:Immunoglobulin G; D008894:Milk Proteins; D016212:Transforming Growth Factor beta; D015847:Interleukin-4; D007073:Immunoglobulin E
keywords: ICR mice; allergenicity; immunomodulatory; milk protein hydrolysate