title: Fiber-optic Fourier transform infrared spectroscopy for remote label-free sensing of medical device surface contamination.
abstract: As a potential major source of biochemical contamination, medical device surfaces are of critical safety concerns in the clinical practice and public health. The development of innovative sensing methods for accurate and real-time detection of medical device surface contamination is essential to protect patients from high risk infection. In this paper, we demonstrate an alternative fiber-optic Fourier Transform Infrared (FTIR) spectroscopy based sensing approach for remote, non-contact, and label-free detection of biochemical contaminants in the mid-infrared (mid-IR) region. The sensing probe is designed using mid-IR hollow fibers and FTIR measurements are carried out in reflection mode. Bovine Serum Albumin (BSA) and bacterial endotoxin of different concentrations under thoroughly dry condition are used to evaluate the detection sensitivity. The devised system can identify ≤0.0025% (≤4 × 10(11) molecules) BSA and 0.5% (0.5 EU/ml) endotoxin concentration. The developed sensing approach may be applied to detect various pathogens that pose public health threats.
authors.affiliation: Optical Therapeutics and Medical Nanophotonics Laboratory, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. moinuddin.hassan@fda.hhs.gov
authors.forename: Moinuddin
authors.initials: M
authors.lastname: Hassan
authors.forename: Xin
authors.initials: X
authors.lastname: Tan
authors.forename: Elissa
authors.initials: E
authors.lastname: Welle
authors.forename: Ilko
authors.initials: I
authors.lastname: Ilev
mesh_terms: D000818:Animals; D002417:Cattle; D004731:Endotoxins / Q000737:chemistry; D004866:Equipment Contamination; D004864:Equipment and Supplies / Q000382:microbiology; D055100:Optical Fibers; D058998:Remote Sensing Technology / Q000295:instrumentation*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000295:instrumentation*; D013499:Surface Properties
chemical_list: D004731:Endotoxins; D012710:Serum Albumin, Bovine; C044101:endotoxin, Escherichia coli