title: Outcome of corpus callosotomy in adults.
abstract: We present, to our knowledge, the first published series of corpus callosotomy (CC) in adults with medically intractable symptomatic generalized epilepsy (SGE). Fifteen adults were followed for the outcome measures of seizure and antiepileptic drug (AED) burden and quality of life (QoL). Five (33%) patients reported >60%, one (7%) reported between 30 and 60%, and nine (60%) reported <30% reduction in the total number of seizures after CC. Seven (47%) patients reported >60%, three (20%) experienced between 30 and 60%, and five (33%) reported <30% atonic seizure reduction. Twelve patients had no change in AED burden. Nine (60%) patients had no change in QoL, while six (40%) reported some improvement. Corpus callosotomy should be considered as a safe option for adults with medically intractable SGE with demonstrated reduction in the frequency of atonic seizures, and some patients experience a meaningful improvement in quality of life.
authors.affiliation: Department of Neurosurgery & Brain Repair, University of South Florida, Tampa, FL, USA. mpark1@health.usf.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Park
authors.forename: Emily
authors.initials: E
authors.lastname: Nakagawa
authors.forename: Mike R
authors.initials: MR
authors.lastname: Schoenberg
authors.forename: Selim R
authors.initials: SR
authors.lastname: Benbadis
authors.forename: Fernando L
authors.initials: FL
authors.lastname: Vale
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D003337:Corpus Callosum / Q000502:physiology* / Q000601:surgery*; D004827:Epilepsy / Q000188:drug therapy / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D011788:Quality of Life; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000927:Anticonvulsants