title: Association between genetic variations in TFR2 gene and coronary heart disease in Chinese: a case-control study.
abstract: OBJECTIVE
  Studies indicated that body iron stores were associated with coronary heart disease (CHD). Type 2 transferrin receptor (TFR2) participates in cellular iron overload and is related to cardiovascular disease. No studies investigated the associations between variants in TFR2 gene and CHD risk.
  
  
  METHODS
  We sought to investigate this association in a Chinese Han population and performed a case-control study recruiting 1264 CHD patients and 1264 age and sex frequency matched controls. TaqMan single nucleotide polymorphisms (SNP) allelic discrimination was used to examine genotypes of the tagging single nucleotide polymorphisms (tagSNPs) of TFR2. The plasma ferritin levels were measured by ELISA.
  
  
  RESULTS
  We did not find significant associations between variants of TFR2 gene (including tagSNPs rs2075674 and rs7385804) and the risk of CHD. After adjustment for the conventional risk factors of CHD, such as smoking and age, the results did not materially alter. Interaction analyses indicated that there were no significant interactions between conventional risk factors of CHD and these two tagSNPs on CHD risk. Among different genotypes of these two tagSNPs, no significant differences in plasma ferritin levels were found.
  
  
  CONCLUSIONS
  In summary, the variants of rs2075674 and rs7385804 in TFR2 gene were not associated with CHD risk in a Chinese Han population.
authors.affiliation: aInstitute of Occupational Medicine and the Ministry of Education Key Lab of Environment and Health bDepartment of Cardiology, Union Hospital, Huazhong University of Science and Technology cDepartment of Cardiology, the People's Hospital of Guangxi Zhuang Autonomous Region, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.forename: Yitian
authors.initials: Y
authors.lastname: Lian
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.forename: Lihong
authors.initials: L
authors.lastname: Huang
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Zhang
authors.forename: Huan
authors.initials: H
authors.lastname: Guo
authors.forename: Tangchun
authors.initials: T
authors.lastname: Wu
authors.forename: Longxian
authors.initials: L
authors.lastname: Cheng
authors.forename: Mei'an
authors.initials: M
authors.lastname: He
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003327:Coronary Disease / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005293:Ferritins / Q000097:blood; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011990:Receptors, Transferrin / Q000235:genetics*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D011990:Receptors, Transferrin; C503640:TFR2 protein, human; D005293:Ferritins