title: Magnetism and spin dynamics of novel encapsulated iron oxide superparamagnetic nanoparticles.
abstract: Encapsulated Fe3O4 nanoparticles of average diameters d = 12 nm are obtained by coprecipitation, in the presence of 2-methoxyethanol hemiester of poly(maleic anhydride-alt-butyl vinyl ether) 5% grafted with poly(ethylene glycol) (VP-MAG nanoparticles). A complete characterization of nude and encapsulated nanoparticles through structural techniques (namely XRD, TEM, SEM), Raman spectroscopy and magnetic measurements has been performed. These nanoparticles compared with commercial compounds (ENDOREM®) present superparamagnetic behavior and nuclear relaxivities that make them promising as magnetic resonance imaging (MRI) contrast agents (CAs). We found that our nanostructures exhibit r2 relaxivity higher than those of commercial CAs over the whole frequency range. The MRI efficiency of our samples was related to their microstructural and magnetic properties.
authors.affiliation: Dipartimento di Fisica, Università degli Studi di Milano, I-20133 Milano, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Arosio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Baldi
authors.forename: Federica
authors.initials: F
authors.lastname: Chiellini
authors.forename: Maurizio
authors.initials: M
authors.lastname: Corti
authors.forename: Alberto
authors.initials: A
authors.lastname: Dessy
authors.forename: Pietro
authors.initials: P
authors.lastname: Galinetto
authors.forename: Matteo
authors.initials: M
authors.lastname: Gazzarri
authors.forename: Marco Simone
authors.initials: MS
authors.lastname: Grandi
authors.forename: Claudia
authors.initials: C
authors.lastname: Innocenti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Lascialfari
authors.forename: Giada
authors.initials: G
authors.lastname: Lorenzi
authors.forename: Francesco
authors.initials: F
authors.lastname: Orsini
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Piras
authors.forename: Costanza
authors.initials: C
authors.lastname: Ravagli
authors.forename: Claudio
authors.initials: C
authors.lastname: Sangregorio
mesh_terms: D004951:Esterification; D004987:Ethers / Q000737:chemistry; D005026:Ethylene Glycols / Q000737:chemistry; D060328:Magnetic Phenomena; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008299:Maleic Anhydrides / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013059:Spectrum Analysis, Raman; D014753:Vinyl Compounds / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D004987:Ethers; D005026:Ethylene Glycols; D058185:Magnetite Nanoparticles; D008299:Maleic Anhydrides; D011108:Polymers; D014753:Vinyl Compounds; C521980:butyl vinyl ether; C016683:polymaleic anhydride; D011092:Polyethylene Glycols; C005219:methyl cellosolve