title: Palladium-catalyzed Z-selective oxidative amination of ortho-substituted primary anilines with olefins under an open air atmosphere.
abstract: The Pd-catalyzed oxidative amination of olefins with primary anilines has been achieved using molecular dioxygen as the sole oxidant. The use of ortho-substituted primary anilines such as ortho-toluidine was the key to the successful development of this reaction, providing the corresponding N-alkenyl substituted anilines in high yields with unusually high levels of Z-selectivity.
authors.affiliation: Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka 564-8680, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Mizuta
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yasuda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Obora
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000586:Amination; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000814:Aniline Compounds; D010165:Palladium; D010100:Oxygen