title: Association between Oro-Facial Defects and Systemic Alterations in Children Affected by Marfan Syndrome.
abstract: BACKGROUND
  It is important to establish an early diagnosis of the Marfan Syndrome (MFS) for providing an adequate pharmacological or surgical therapy. Nevertheless, this diagnosis may be complex, given the multi-organic involvement of this disease.
  
  
  OBJECTIVE
  In this work, we evaluated the oral phenotype in a group of paediatric patients with a clinical diagnosis of MFS, to quantify the association of the oro-facial defects with other systemic alterations.
  
  
  METHODS
  Paediatric subjects who were aged, with a clinical diagnosis of MFS, were selected from our regional Marfan monitoring unit.
  
  
  METHODS
  All the patients were subjected to Paediatric Dentistry examinations and a radiological screening with Panoramic and Cephalometric X-Rays. The aortic dilation (Aortic Z-score value), the hyperlaxity of the ligaments and scoliosis were evaluated by cardio-surgical and orthopaedics specialists.
  
  
  METHODS
  The correlations between the oral and systemic alterations were analyzed by using the chi square test for the nominal variables.
  
  
  CONCLUSIONS
  We found a significant correlation of the Aortic Z - score with multiple oral defects which included retrognathia, malar hypoplasia, cross bite, oral respiration and an ogival palate. An association of the oral defects with hyperlaxity of the ligaments and scoliosis was also found. Thus, the data suggested that dentists should be more involved in a multidisciplinary approach, to provide an early MFS diagnosis in paediatric patients.
authors.affiliation: Department of Experimental Medicine & Surgery, Pediatric Dentistry.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Docimo
authors.forename: Paolo
authors.initials: P
authors.lastname: Maturo
authors.forename: Francesca
authors.initials: F
authors.lastname: D'Auria
authors.forename: Susanna
authors.initials: S
authors.lastname: Grego
authors.forename: Micaela
authors.initials: M
authors.lastname: Costacurta
authors.forename: Cesare
authors.initials: C
authors.lastname: Perugia
authors.forename: Luigi
authors.initials: L
authors.lastname: Chiariello
keywords: Marfan syndrome; cardiological and orthopedic characteristics; diagnosis; orofacial defects; pediatric dentistry