title: Preparation and characterization of nano-hydroxyapatite nanomaterials for liver cancer cell treatment.
abstract: Nano-hydroxyapatite was synthesized by means of the hydrothermal treatment. The effects of nano-hydroxyapatite material on the behaviour of G2 liver cancer cells were explored. About 50% of cell viability was lost in nHAp material treated cells at 200 degrees C @ 5 h, followed by -30% in nHAp treated cells at 100 degrees C @ 5 h. Compared with control, nHAp material treated cells at 200 degrees C @ 5 h showed 60% and nHAp material treated cells at 100 degrees C @ 5 h showed 15% morphological change. Moreover, 50% of cell death was observed at 24 h incubation with nHAp material treated at 200 degrees C @ 5 h cells and 56% cell death at 48 h incubation and hence alters and disturbs the growth of cancer cells. In contrast, the nHAp material treated at 100 degrees C @ 5 h protects the cells and could be used for liver cancer cell treatment.
authors.affiliation: Center for Nanoscience and Technology, K. S. Rangasamy College of Technology, Tiruchengode 637215, Tamil Nadu, India.
authors.forename: Sathiyamoorthy
authors.initials: S
authors.lastname: Ezhaveni
authors.forename: Rathinam
authors.initials: R
authors.lastname: Yuvakkumar
authors.forename: Mani
authors.initials: M
authors.lastname: Rajkumar
authors.forename: Nachiappan Meenakshi
authors.initials: NM
authors.lastname: Sundaram
authors.forename: Venkatachalam
authors.initials: V
authors.lastname: Rajendran
mesh_terms: D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D017886:Durapatite / Q000494:pharmacology*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures; D010316:Particle Size; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D017886:Durapatite