title: [Interest and limits of inductively coupled plasma mass spectrometry (ICP-MS) for urinary diagnosis of radionuclide internal contamination].
abstract: After a review of radiometric reference methods used in radiotoxicology, analytical performance of inductively coupled plasma mass spectrometry (ICP-MS) for the workplace urinary diagnosis of internal contamination by radionuclides are evaluated. A literature review (covering the period from 2000 to 2012) is performed to identify the different applications of ICP-MS in radiotoxicology for urine analysis. The limits of detection are compared to the recommendations of the International commission on radiological protection (ICRP 78: "Individual monitoring for internal exposure of workers"). Except one publication describing the determination of strontium-90 (β emitter), all methods using ICP-MS reported in the literature concern actinides (α emitters). For radionuclides with a radioactive period higher than 10(4) years, limits of detection are most often in compliance with ICRP publication 78 and frequently lower than radiometric methods. ICP-MS allows the specific determination of plutonium-239 + 240 isotopes which cannot be discriminated by α spectrometry. High resolution ICP-MS can also measure uranium isotopic ratios in urine for total uranium concentrations lower than 20 ng/L. The interest of ICP-MS in radiotoxicology concerns essentially the urinary measurement of long radioactive period actinides, particularly for uranium isotope ratio determination and 239 and 240 plutonium isotopes discrimination. Radiometric methods remain the most efficient for the majority of other radionuclides.
authors.affiliation: Service de protection radiologique des armées, Clamart, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Lecompte
authors.forename: Sandra
authors.initials: S
authors.lastname: Bohand
authors.forename: Pierre
authors.initials: P
authors.lastname: Laroche
authors.forename: Alain
authors.initials: A
authors.lastname: Cazoulat
mesh_terms: D008671:Actinoid Series Elements / Q000652:urine; D005507:Food Contamination, Radioactive / Q000032:analysis; D006801:Humans; D057230:Limit of Detection; D009784:Occupational Diseases / Q000652:urine*; D011237:Predictive Value of Tests; D011834:Radiation Monitoring / Q000379:methods; D011868:Radioisotopes / Q000652:urine*; D013054:Spectrophotometry, Atomic / Q000379:methods*; D013326:Strontium Radioisotopes / Q000652:urine; D016482:Urinalysis / Q000379:methods*
chemical_list: D008671:Actinoid Series Elements; D011868:Radioisotopes; D013326:Strontium Radioisotopes
keywords: actinides; inductively coupled plasma mass spectrometry (ICP-MS); radiotoxicology; strontium-90; urine