title: The H2A/H2B-like histone-fold domain proteins at the crossroad between chromatin and different DNA metabolisms.
abstract: Core histones are the building block of chromatin and among the most highly conserved proteins in eukaryotes. The related "deviant" histones share the histone-fold domain, and serve various roles in DNA metabolism. We provide here a structural and functional outlook of H2A/H2B-like deviant histones in transcription, replication and remodeling.
authors.affiliation: Dipartimento di Bioscienze; Università degli Studi di Milano; Milano, Italy.
authors.forename: Nerina
authors.initials: N
authors.lastname: Gnesutta
authors.forename: Marco
authors.initials: M
authors.lastname: Nardini
authors.forename: Roberto
authors.initials: R
authors.lastname: Mantovani
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D023081:CCAAT-Binding Factor / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D004261:DNA Replication; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D009707:Nucleosomes / Q000378:metabolism; D011401:Promoter Regions, Genetic; D017434:Protein Structure, Tertiary; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D014981:Xenopus / Q000378:metabolism
chemical_list: D023081:CCAAT-Binding Factor; D002843:Chromatin; D006657:Histones; D009707:Nucleosomes; D014157:Transcription Factors; D004247:DNA
keywords: H2A/H2B; NC2; NF-Y; TAF4/12; chromatin; chromatin remodeling complex; histone-fold; nucleosome; posttranslational modifications; transcription factors