title: Amoxicillin/metronidazole therapy may improve the effectiveness of scaling and root planing in patients with periodontitis.
abstract: SYSTEMATIC REVIEW CONCLUSION: Preliminary evidence suggests scaling and root planing (SRP) in combination with amoxicillin (AMX)/metronidazole (MET)(SRP + AMX/MET) therapy may be more effective in treating chronic periodontitis(CP) than is SRP alone. CRITICAL SUMMARY ASSESSMENT: Preliminary evidence from a meta-analysis of four randomized clinical trials (RCTs) seems to support the effectiveness of systemic AMX/MET therapy as an adjunct to SRP alone in treating CP, although safety data are incomplete. EVIDENCE QUALITY RATING: Limited.
authors.affiliation: lvpowell@heganglassworks.com
authors.forename: L Virginia
authors.initials: LV
authors.lastname: Powell
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D055113:Chronic Periodontitis / Q000188:drug therapy*; D012534:Dental Scaling; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage*
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole; D000658:Amoxicillin