title: A new DUB makes linear ubiquitin a party to its own destruction.
abstract: Linear ubiquitin (Ub) plays a role in nuclear factor κB signaling, but the deubiquitinating enzyme that disassembles these chains was unknown. In this issue of Cell, Keusekotten et al. identify a new enzyme that disassembles linear chains with the use of a mechanism that relies on Ub itself to help catalyze peptide bond cleavage.
authors.affiliation: Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel-Canada, Hadassah Medical School, Hebrew University, Jerusalem 91120, Israel.
authors.forename: Reuven
authors.initials: R
authors.lastname: Wiener
authors.forename: Cynthia
authors.initials: C
authors.lastname: Wolberger
mesh_terms: D000818:Animals; D010450:Endopeptidases / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans
chemical_list: D010450:Endopeptidases; C582107:OTULIN protein, human