title: Iron-catalyzed oxidative cross-coupling of phenols and alkenes.
abstract: A novel bioinspired iron-catalyzed oxidative cross-coupling reaction between phenols and conjugated alkenes was developed. This method enables the direct coupling of phenols with styrene, α-alkyl- and α-arylstyrenes, β-alkyl styrenes, and stilbenes, thereby providing a new strategy for the preparation of the pharmacologically important 2,3-dihydrobenzofuran motif. In addition, this study revealed that under a different set of conditions an oxidative/addition dearomatization reaction of 1,1'-bi-2-naphthol (BINOL) with styrene can take place.
authors.affiliation: Department of Chemistry, Ben-Gurion University of the Negev , Beer-Sheva 84105, Israel.
authors.forename: Umesh A
authors.initials: UA
authors.lastname: Kshirsagar
authors.forename: Clil
authors.initials: C
authors.lastname: Regev
authors.forename: Regev
authors.initials: R
authors.lastname: Parnes
authors.forename: Doron
authors.initials: D
authors.lastname: Pappo
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry*; D010084:Oxidation-Reduction; D058451:Oxidative Coupling; D010636:Phenols / Q000737:chemistry*; D013343:Styrenes / Q000737:chemistry*
chemical_list: D000475:Alkenes; D009284:Naphthols; D010636:Phenols; D013343:Styrenes; C412332:1,1'-bi-2-naphthol; D007501:Iron