title: Synthesis antimicrobial and antioxidant studies of new oximes of steroidal chalcones.
abstract: A convenient synthesis of oximes of steroidal chalcones (4a-4j) was performed and structural assignment of the products was confirmed on the basis of IR, (1)HNMR, (13)C NMR, MS and analytical data. The synthesized compounds were screened for in vitro antioxidant activity by using DPPH method and in vitro antimicrobial activity against different bacterial and fungal strains by agar diffusion method. The activity of the tested compounds against each microbe varied due to structural differences between them. Presence and position of different substituents on the benzene ring of the chalconyl pendent had a marked effect on the activity of the compounds. From the results it can be inferred that the compounds 4a-j showed significant antioxidant activity and antimicrobial activity against all microbial strains used for testing.
authors.affiliation: Department of Chemistry, University of Kashmir, Srinagar 190009, J&K, India. hussainjamia5@gmail.com
authors.forename: Imtiyaz H
authors.initials: IH
authors.lastname: Lone
authors.forename: Khaliquz Z
authors.initials: KZ
authors.lastname: Khan
authors.forename: Bharat I
authors.initials: BI
authors.lastname: Fozdar
authors.forename: Fida
authors.initials: F
authors.lastname: Hussain
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D001713:Biphenyl Compounds / Q000737:chemistry; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D052978:Disk Diffusion Antimicrobial Tests; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005609:Free Radicals / Q000737:chemistry; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010408:Penicillium chrysogenum / Q000187:drug effects; D010851:Picrates / Q000737:chemistry; D011514:Proteus vulgaris / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001713:Biphenyl Compounds; D047188:Chalcones; D016166:Free Radical Scavengers; D005609:Free Radicals; D010091:Oximes; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Antimicrobial; Oximes; Pregnenolone