title: Pathology and disease mechanisms in different stages of multiple sclerosis.
abstract: In this review the differences in pathology and disease mechanisms between early and late stages of multiple sclerosis are discussed. The data suggest that affection of the brain is different, depending on the location of lesions, on the stage of the disease, when lesions arise, and on inter-individual differences between patients. We suggest that in the early stage of the disease new lesions are formed by new waves of inflammatory cells, entering the central nervous system from the circulation and giving rise to focal demyelinated plaques in the white and gray matter. In contrast, at late stages of the disease inflammation decreases, but the susceptibility of the target tissue for neurodegeneration increases. New data suggest that mitochondrial injury, mediated through oxidative injury, is in the center of the pathogenetic events leading to brain damage in multiple sclerosis patients.
authors.affiliation: Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Wien, Austria. Electronic address: hans.lassmann@meduniwien.ac.at.
authors.forename: Hans
authors.initials: H
authors.lastname: Lassmann
mesh_terms: D001921:Brain / Q000473:pathology*; D003711:Demyelinating Diseases / Q000150:complications / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000473:pathology; D008928:Mitochondria / Q000473:pathology; D009103:Multiple Sclerosis / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D009410:Nerve Degeneration / Q000150:complications / Q000473:pathology; D018384:Oxidative Stress
keywords: Demyelination; Inflammation; Mitochondria; Multiple sclerosis; Neurodegeneration; Oxidative injury