title: R-loops in bacterial transcription: their causes and consequences.
abstract: Nascent untranslated transcripts in bacteria are prone to generating RNA-DNA hybrids (R-loops); Rho-dependent transcription termination acts to reduce their prevalence. Here we discuss the mechanisms of R-loop formation and growth inhibition in bacteria.
authors.affiliation: Laboratory of Bacterial Genetics; Centre for DNA Fingerprinting and Diagnostics; Hyderabad, India.
authors.forename: J
authors.initials: J
authors.lastname: Gowrishankar
authors.forename: J Krishna
authors.initials: JK
authors.lastname: Leela
authors.forename: K
authors.initials: K
authors.lastname: Anupama
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication; D004269:DNA, Bacterial / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D010445:Peptide Elongation Factors / Q000235:genetics / Q000378:metabolism; D012329:RNA, Bacterial / Q000378:metabolism*; D012234:Rho Factor / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D010445:Peptide Elongation Factors; D012329:RNA, Bacterial; D012234:Rho Factor; D014157:Transcription Factors; D012321:DNA-Directed RNA Polymerases
keywords: NusG; R-loop; Rho; backtracking; transcription termination