title: Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury.
abstract: Post-concussion syndrome has been related to axonal damage in patients with mild traumatic brain injury, but little is known about the consequences of injury on brain networks. In the present study, our aim was to characterize changes in functional brain networks following mild traumatic brain injury in patients with post-concussion syndrome using resting-state functional magnetic resonance imaging data. We investigated 17 injured patients with persistent post-concussion syndrome (under the DSM-IV criteria) at 6 months post-injury compared with 38 mild traumatic brain injury patients with no post-concussion syndrome and 34 healthy controls. All patients underwent magnetic resonance imaging examinations at the subacute (1-3 weeks) and late (6 months) phases after injury. Group-wise differences in functional brain networks were analyzed using graph theory measures. Patterns of long-range functional networks alterations were found in all mild traumatic brain injury patients. Mild traumatic brain injury patients with post-concussion syndrome had greater alterations than patients without post-concussion syndrome. In patients with post-concussion syndrome, changes specifically affected temporal and thalamic regions predominantly at the subacute stage and frontal regions at the late phase. Our results suggest that the post-concussion syndrome is associated with specific abnormalities in functional brain network that may contribute to explain deficits typically observed in PCS patients.
authors.affiliation: Inserm, UPMC Univ Paris 06, UMRS 678, Laboratoire d'Imagerie Fonctionnelle, Paris, France. Arnaud.Messe@imed.jussieu.fr
authors.forename: Arnaud
authors.initials: A
authors.lastname: Messé
authors.forename: Sophie
authors.initials: S
authors.lastname: Caplain
authors.forename: Mélanie
authors.initials: M
authors.lastname: Pélégrini-Issac
authors.forename: Sophie
authors.initials: S
authors.lastname: Blancho
authors.forename: Richard
authors.initials: R
authors.lastname: Lévy
authors.forename: Nozar
authors.initials: N
authors.lastname: Aghakhani
authors.forename: Michèle
authors.initials: M
authors.lastname: Montreuil
authors.forename: Habib
authors.initials: H
authors.lastname: Benali
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lehéricy
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology; D001930:Brain Injuries / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D038223:Post-Concussion Syndrome / Q000209:etiology* / Q000503:physiopathology*