title: Stable gastric pentadecapeptide BPC 157-NO-system relation.
abstract: We reviewed stable gastric pentadecapeptide BPC 157-NO-system-relation, its close participation in Moncada's (maintained vascular integrity, platelets control) homeostatic healing response of NO-system to injury. Namely, BPC 157's particular healing effect also affects all events after vascular integrity loss (dependent on circumstances, it reduces either thrombosis (abdominal aorta anastomosis) or bleeding/thrombocytopenia (amputation, heparin, warfarin, aspirin)) and in a series of different injurious models, acute and chronic, BPC 157 consistently advances healing after severe injuries in various tissues spontaneously unable to heal; stimulates egr-1 and naB2 genes; exhibits high safety (LD1 not achieved)). Hypothesis, that BPC 157 (since formed constitutively in the gastric mucosa, stable in human gastric juice, along with significance of NO-synthase and the basal formation of NO in stomach mucosa, greater than that seen in other tissues) exhibits a general, effective competing both with L-arginine analogues (i. e., L-NAME) and L-arginine, and that this has some physiologic importance (NO-generation), later, practically supports its beneficial effects illustrating BPC 157 and NOsystem mutual (with L-NAME/L-arginine; alone and together) relations in (i) gastric mucosa and mucosal protection, following alcohol lesions, in cytoprotection course, NO-generation, and blood pressure regulation; (ii) alcohol acute/chronic intoxication, and withdrawal; (iii) cardiovascular disturbances, chronic heart failure, pulmonary hypertension, and arrhythmias; (iv) disturbances after hypokalemia and hyperkalemia, and potassium-cell membrane dysfunction; and finally, in (v) complex healing failure, proved by the fistulas healing, colocutaneous and esophagocutaneous. However, how this advantage of modulating NO-system (i. e., particular effect on eNOS gene), may be practically translated into an enhanced clinical performance remains to be determined.
authors.forename: Predrag
authors.initials: P
authors.lastname: Sikiric
authors.forename: Sven
authors.initials: S
authors.lastname: Seiwerth
authors.forename: Rudolf
authors.initials: R
authors.lastname: Rucman
authors.forename: Branko
authors.initials: B
authors.lastname: Turkovic
authors.forename: Dinko Stancic
authors.initials: DS
authors.lastname: Rokotov
authors.forename: Luka
authors.initials: L
authors.lastname: Brcic
authors.forename: Marko
authors.initials: M
authors.lastname: Sever
authors.forename: Robert
authors.initials: R
authors.lastname: Klicek
authors.forename: Bozo
authors.initials: B
authors.lastname: Radic
authors.forename: Domagoj
authors.initials: D
authors.lastname: Drmic
authors.forename: Spomenko
authors.initials: S
authors.lastname: Ilic
authors.forename: Danijela
authors.initials: D
authors.lastname: Kolenc
authors.forename: Gorana
authors.initials: G
authors.lastname: Aralica
authors.forename: Mirjana
authors.initials: M
authors.lastname: Stupnisek
authors.forename: Jelena
authors.initials: J
authors.lastname: Suran
authors.forename: Ivan
authors.initials: I
authors.lastname: Barisic
authors.forename: Senka
authors.initials: S
authors.lastname: Dzidic
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Vrcic
authors.affiliation: Department of Pharmacology, Medical Faculty University of Zagreb, Salata 11, POB 916, 10000 Zagreb, Croatia. sikiric@mef.hr.
authors.forename: Bozidar
authors.initials: B
authors.lastname: Sebecic
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D011506:Proteins / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
chemical_list: D010446:Peptide Fragments; D011506:Proteins; D009569:Nitric Oxide; C083833:BPC 157