title: Perioperative oxygen supplementation and surgical site infection after cesarean delivery: a randomized trial.
abstract: OBJECTIVE
  To evaluate whether supplemental perioperative oxygen decreases surgical site wound infections or endometritis.
  
  
  METHODS
  This was a prospective, randomized trial. Patients who were to undergo cesarean delivery were recruited and randomly allocated to either 30% or 80% oxygen during the cesarean delivery and for 1 hour after surgery. The obstetricians and patients were blinded to the concentration of oxygen used. Patients were evaluated for wound infection or endometritis during their hospital stay and by 6 weeks postpartum. The primary end point was a composite of either surgical site infection or endometritis.
  
  
  RESULTS
  Eight hundred thirty-one patients were recruited. Of these, 415 participants received 30% oxygen perioperatively and 416 received 80% oxygen. The groups were well matched for age, race, parity, diabetes, number of previous cesarean deliveries, and scheduled compared with unscheduled cesarean deliveries. An intention-to-treat analysis was used. There was no difference in the primary composite outcome (8.2% in women who received 30% oxygen compared with 8.2% in women who received 80% oxygen, P=.89), no difference in surgical site infection in the two groups (5.5% compared with 5.8%, P=.98), and no significant difference in endometritis in the two groups (2.7% compared with 2.4%, P=.66), respectively.
  
  
  CONCLUSIONS
  Women who received 80% supplemental oxygen perioperatively did not have a lower rate of a surgical site infection or endometritis as compared with women who received 30% supplemental oxygen concentration.
  
  
  BACKGROUND
  ClinicalTrials.gov, www.clincaltrials.gov, NCT00876005.
  
  
  METHODS
  I.
authors.affiliation: Departments of Obstetrics and Gynecology, Santa Clara Valley Medical Center, San Jose, California, and Oregon Health and Science University, Portland, Oregon.
authors.forename: Neena
authors.initials: N
authors.lastname: Duggal
authors.forename: Vineela
authors.initials: V
authors.lastname: Poddatorri
authors.forename: Sara
authors.initials: S
authors.lastname: Noroozkhani
authors.forename: R Iram
authors.initials: RI
authors.lastname: Siddik-Ahmad
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Caughey
mesh_terms: D000328:Adult; D002585:Cesarean Section / Q000009:adverse effects*; D004311:Double-Blind Method; D004716:Endometritis / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D010100:Oxygen / Q000627:therapeutic use*; D011247:Pregnancy; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D010100:Oxygen