title: [Current insights into the pathophysiology of rosacea].
abstract: Rosacea is a chronic inflammatory skin disease mainly affecting the face. Four major clinical subtypes of rosacea can be identified: erythemato-telangiectatic, papulopustular, phymatous and ocular rosacea. Still, it is currently unclear whether these subtypes develop consecutively or if any subtypes may occur individually as part of a syndrome. Rosacea is characterized by facial flushing, erythema, chronic inflammation, edema and fibrosis. Several trigger factors can worsen the disease or cause recurring episodes of inflammation. Although some aspects in the pathophysiology of rosacea have been characterized in more detail during the past years, the precise interplay of the various dysregulated systems is still poorly understood. In early disease manifestations and milder stages, dysfunction of neurovascular regulation and the innate immune system seem to be driving forces in rosacea pathophysiology. A disturbed chemokine and cytokine network further contributes to disease progression. This current review highlights some of the recent findings in rosacea pathophysiology and points out novel targets for therapeutic intervention.
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie, Ludwigs Maximilians Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland. Juergen.schauber@med.uni-muenchen.de
authors.forename: J
authors.initials: J
authors.lastname: Schauber
authors.forename: B
authors.initials: B
authors.lastname: Homey
authors.forename: M
authors.initials: M
authors.lastname: Steinhoff
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D016207:Cytokines / Q000276:immunology*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology*; D018448:Models, Immunological; D012393:Rosacea / Q000188:drug therapy* / Q000276:immunology*; D012867:Skin / Q000187:drug effects / Q000276:immunology*
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D003879:Dermatologic Agents