title: Rhesus macaque rhadinovirus-associated disease.
abstract: Rhesus macaque rhadinovirus (RRV) is a gamma-2 herpesvirus that naturally infects rhesus macaque (RM) monkeys and is closely related to human herpesvirus-8 (HHV-8)/Kaposi's sarcoma-associated herpesvirus (KSHV). Infection of immunodeficient RM induces disease in infected RM that resembles KSHV-associated pathologies. Importantly, RRV possesses homologues of KSHV ORFs that are postulated to play a role in disease development. As such, RRV has emerged as a prominent in vivo model system for examining mechanisms of infection and disease of these pathogenic herpesviruses, and has provided unique insight into how these viruses cause disease.
authors.affiliation: Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, United States.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Estep
authors.forename: Scott W
authors.initials: SW
authors.lastname: Wong
mesh_terms: D000818:Animals; D006566:Herpesviridae Infections / Q000473:pathology* / Q000821:virology*; D008253:Macaca mulatta; D018419:Primate Diseases / Q000473:pathology* / Q000821:virology*; D018144:Rhadinovirus / Q000472:pathogenicity*; D014412:Tumor Virus Infections / Q000473:pathology* / Q000821:virology*