title: Design, methods, and population for a study of PFOA health effects among highly exposed mid-Ohio valley community residents and workers.
abstract: BACKGROUND
  A cohort of community residents and workers is the basis for a series of epidemiologic studies of a Mid-Ohio Valley population with substantial perfluorooctanoic acid (PFOA) exposure due to releases from a chemical plant.
  
  
  OBJECTIVE
  We describe study design, methods, and study participants for a longitudinal cohort study of associations between PFOA exposure and adult chronic diseases.
  
  
  METHODS
  Two cohorts were formed, one recruited from community residents who participated in a previous community-wide survey, and one from plant workers. Study participants were interviewed during 2008-2011 regarding demographics, health-related behaviors, and personal history of chronic diseases. Reported diseases were validated through medical records review and registry matching. Here we describe cohort characteristics, compare survey respondents and nonrespondents, provide data on the number of diseases reported and validated, and describe historical estimates of serum PFOA concentrations over time.
  
  
  RESULTS
  The final combined cohort included 32,254 participants (28,541 community; 3,713 worker). Participation rates were high (community, 81.5%; worker, 72.9% of target population). The final population from each cohort was representative of the target population in terms of demographic characteristics and measured serum PFOA concentrations in 2005-2006. The study had a wide exposure range and the number of reported cases of chronic diseases was high, resulting in greater power to detect associations than has been the case for many previous studies.
  
  
  CONCLUSIONS
  This is the largest study to date of the health effects of PFOA. The information from this cohort is being used to examine associations between PFOA exposure and multiple adult chronic diseases.
authors.affiliation: Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Winquist
authors.forename: Cathy
authors.initials: C
authors.lastname: Lally
authors.forename: Hyeong-Moo
authors.initials: HM
authors.lastname: Shin
authors.forename: Kyle
authors.initials: K
authors.lastname: Steenland
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002210:Caprylates / Q000097:blood / Q000633:toxicity*; D002908:Chronic Disease / Q000453:epidemiology*; D004781:Environmental Exposure; D004784:Environmental Monitoring; D005260:Female; D005466:Fluorocarbons / Q000097:blood / Q000633:toxicity*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D009820:Ohio / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D014874:Water Pollutants, Chemical / Q000097:blood / Q000633:toxicity*; D014903:West Virginia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D002210:Caprylates; D005466:Fluorocarbons; D014874:Water Pollutants, Chemical; C023036:perfluorooctanoic acid