title: Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy.
abstract: Despite initial promising results, the success of clinical trials testing oncolytic viruses in glioblastoma patients has been limited. Innate immunity appears to be one among several barriers against successful viral oncolysis. Recent findings suggest a mechanism by which natural killer cells limit the efficacy of oncolytic viruses via natural cytotoxicity receptors.
authors.affiliation: Medical Scientist Training Program; The Ohio State University Medical Center; Columbus, OH USA ; Dardinger Laboratory for Neuro-Oncology and Neurosciences; Department of Neurological Surgery; The Ohio State University Medical Center; Columbus, OH USA.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Alvarez-Breckenridge
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yu
authors.forename: Michael A
authors.initials: MA
authors.lastname: Caligiuri
authors.forename: E Antonio
authors.initials: EA
authors.lastname: Chiocca
keywords: brain tumor; cancer; glioblastoma; innate immunity; oncolytic virus