title: Intramolecular carbocupration of N-aryl-ynamides: a modular indole synthesis.
abstract: A modular indole synthesis based on an intramolecular 5-endo-dig carbocupration starting from readily available N-aryl-ynamides is reported. A variety of ynamides are converted to indoles in moderate to good yields and with varying substitution pattern on the indole ring. This further extends the synthetic utility of ynamides in organic synthesis and provides additional insights on the use of intramolecular carbometalation reactions.
authors.affiliation: Institut Lavoisier de Versailles, UMR CNRS 8180, Université de Versailles Saint-Quentin en Yvelines , 45, avenue des Etats-Unis, 78035 Versailles Cedex, France, Laboratoire de Chimie Hétérocyclique, Produits Naturels et Réactivité, Département de Chimie, Faculté des Sciences de Monastir, Université de Monastir , avenue de l'environnement, 5019 Monastir, Tunisia, and Laboratoire de Chimie Organique, Service de Chimie et PhysicoChimie Organiques, Université Libre de Bruxelles , Avenue F. D. Roosevelt 50, CP160/06, 1050 Brussels, Belgium.
authors.forename: Wafa
authors.initials: W
authors.lastname: Gati
authors.forename: François
authors.initials: F
authors.lastname: Couty
authors.forename: Taoufik
authors.initials: T
authors.lastname: Boubaker
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Rammah
authors.forename: Mohamed B
authors.initials: MB
authors.lastname: Rammah
authors.forename: Gwilherm
authors.initials: G
authors.lastname: Evano