title: Whole-body cryostimulation as an effective method of reducing low-grade inflammation in obese men.
abstract: This study was aimed to evaluate anti-inflammatory effect of the whole body cryostimulation in obese men. Fourteen subjects (BMI >30 kg m(-2)), divided into two subgroups according to cardiorespiratory fitness: higher (HCF) or lower (LCF), have been exposed to 10 sessions in a cryogenic chamber (-110 °C). Blood samples were collected before, 30 min and 24 h after the first, fifth and last cryostimulation. Coldness exposures affected blood cytokine profile; however, the response depended on subjects' fitness capacity. Concentrations of pro-inflammatory cytokines in the LCF decreased by 19, 6.8, and 7.4 % in IL-6, resistin, and visfatin, respectively. TNFα in the LCF dropped 4.3-fold compared to baseline, while in the HCF, changes were smaller, yet significant. Anti-inflammatory cytokine IL-10 increased in both groups. No changes in adiponectin and leptin were observed in either group. Obtained results suggest that whole body cryostimulation can be a supplementary method for obese in reducing systemic inflammation.
authors.affiliation: Department of Physiology, Gdansk University of Physical Education and Sport, Kazimierza Górskiego 1, 80-336, Gdansk, Poland. ewann@awf.gda.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Ziemann
authors.forename: Robert A
authors.initials: RA
authors.lastname: Olek
authors.forename: Tomasz
authors.initials: T
authors.lastname: Grzywacz
authors.forename: Jędrzej
authors.initials: J
authors.lastname: Antosiewicz
authors.forename: Sylwester
authors.initials: S
authors.lastname: Kujach
authors.forename: Marcin
authors.initials: M
authors.lastname: Łuszczyk
authors.forename: Mirosław
authors.initials: M
authors.lastname: Smaruj
authors.forename: Ewelina
authors.initials: E
authors.lastname: Sledziewska
authors.forename: Radosław
authors.initials: R
authors.lastname: Laskowski
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D003080:Cold Temperature; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000503:physiopathology*; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood; D009765:Obesity / Q000097:blood* / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D052242:Adiponectin; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D054409:Nicotinamide Phosphoribosyltransferase