title: Antimicrobial activity of crude methanolic extract from Phyllanthus niruri.
abstract: The antibacterial efficiency of the methanolic extract of Phyllanthus niruri Linn. was investigated against pathogenic bacteria responsible for common infections of skin, and urinary and gastrointestinal tracts. The extract demonstrated antibacterial activities against all the Gram-positive and Gram-negative bacteria tested. The results obtained suggested that at higher concentrations the extract would eradicate the growth of bacterial cells. The bacterial cells, after exposure to the extract, showed complete alteration in their morphology, followed by collapse of the cells beyond repair. The study revealed that the methanolic extract of P. niruri may be an effective antibacterial agent to treat bacterial infections since the extract exhibited significant antimicrobial potency, comparable with that of the standard antibiotic chloramphenicol.
authors.affiliation: Industrial Biotechnology Research Laboratory (IBRL), School of Biological Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
authors.forename: Darah
authors.initials: D
authors.lastname: Ibrahim
authors.forename: Lim Sheh
authors.initials: LS
authors.lastname: Hong
authors.forename: Ninthianantham
authors.initials: N
authors.lastname: Kuppan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D029803:Phyllanthus; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts