title: Bioactive lignans from the leaves and stems of Schisandra wilsoniana.
abstract: Three new dibenzocyclooctadiene lignans, marlignans M-O (1-3), together two known ones, were isolated from the leaves and stems of Schisandra wilsoniana. The structures of 1-3 were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 2 showed anti-HIV-1 activity with an EC50 value of 5.82 microg/mL and a therapeutic index (TI) of more than 12.8. Compound 3 showed obvious bioactivity in inhibiting Epstein-Barr virus early antigen (EBV-EA) activation.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Yang
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Wang
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Gao
authors.forename: Yin-Ke
authors.initials: YK
authors.lastname: Lia
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Shan-Zhai
authors.initials: SZ
authors.lastname: Shang
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000956:Antigens, Viral / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D017705:Lignans