title: One-pot aqueous synthesis of sub-10 nm responsive nanogels.
abstract: A strategy involving free radical copolymerization of a difunctional oligomer and a small-molecule crosslinker to give sub-10 nm nanogels is proposed. These nanogels can adapt to surrounding temperatures and regulate the release of a preloaded model anticancer drug 5-fluorouracil.
authors.affiliation: State Key Laboratory for Physical Chemistry of Solid Surfaces, and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
authors.forename: Luxian
authors.initials: L
authors.lastname: Li
authors.forename: Aiping
authors.initials: A
authors.lastname: Chang
authors.forename: Yumei
authors.initials: Y
authors.lastname: Hu
authors.forename: Laiying
authors.initials: L
authors.lastname: Zhang
authors.forename: Weitai
authors.initials: W
authors.lastname: Wu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D005472:Fluorouracil / Q000737:chemistry / Q000494:pharmacology; D005782:Gels / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D058105:Polymerization; D013696:Temperature; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D005782:Gels; D008689:Methacrylates; D014753:Vinyl Compounds; C421283:poly(ethylene glycol)-dimethacrylate; D011092:Polyethylene Glycols; C004985:divinyl benzene; D005472:Fluorouracil