title: Recovery of fine motor performance after ischemic damage to motor cortex is facilitated by cell therapy in the rhesus monkey.
abstract: We investigated the efficacy on recovery of function following controlled cortical ischemia in the monkey of the investigational cell drug product, CNTO 0007. This drug contains a cellular component, human umbilical tissue-derived cells, in a proprietary thaw and inject formulation. Results demonstrate significantly better recovery of motor function in the treatment group with no difference between groups in the volume or surface area of ischemic damage, suggesting that the cells stimulated plasticity.
authors.affiliation: Department of Anatomy & Neurobiology, Boston University School of Medicine , Boston, MA , USA .
authors.forename: Tara L
authors.initials: TL
authors.lastname: Moore
authors.forename: Monica A
authors.initials: MA
authors.lastname: Pessina
authors.forename: Seth P
authors.initials: SP
authors.lastname: Finklestein
authors.forename: Brian C
authors.initials: BC
authors.lastname: Kramer
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Killiany
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Rosene
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D004195:Disease Models, Animal; D004569:Electroencephalography; D007839:Functional Laterality / Q000502:physiology; D018737:Hand Strength / Q000502:physiology; D008253:Macaca mulatta; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009048:Motor Skills / Q000502:physiology*; D009069:Movement Disorders / Q000209:etiology / Q000601:surgery; D020127:Recovery of Function / Q000502:physiology*; D016037:Single-Blind Method; D034941:Upper Extremity / Q000503:physiopathology