title: Phospholipid micelle-based magneto-plasmonic nanoformulation for magnetic field-directed, imaging-guided photo-induced cancer therapy.
abstract: We present a magnetoplasmonic nanoplatform combining gold nanorods (GNR) and iron-oxide nanoparticles within phospholipid-based polymeric nanomicelles (PGRFe). The gold nanorods exhibit plasmon resonance absorbance at near infrared wavelengths to enable photoacoustic imaging and photothermal therapy, while the Fe3O4 nanoparticles enable magnetophoretic control of the nanoformulation. The fabricated nanoformulation can be directed and concentrated by an external magnetic field, which provides enhancement of a photoacoustic signal. Application of an external field also leads to enhanced uptake of the magnetoplasmonic formulation by cancer cells in vitro. Under laser irradiation at the wavelength of the GNR absorption peak, the PGRFe formulation efficiently generates plasmonic nanobubbles within cancer cells, as visualized by confocal microscopy, causing cell destruction. The combined magnetic and plasmonic functionalities of the nanoplatform enable magnetic field-directed, imaging-guided, enhanced photo-induced cancer therapy.
  
  
  BACKGROUND
  In this study, a nano-formulation of gold nanorods and iron oxide nanoparticles is presented using a phospholipid micelle-based delivery system for magnetic field-directed and imaging-guided photo-induced cancer therapy. The gold nanorods enable photoacoustic imaging and photothermal therapy, while the Fe3O4 nanoparticles enable magnetophoretic control of the formulation. This and similar systems could enable more precise and efficient cancer therapy, hopefully in the near future, after additional testing.
authors.affiliation: Institute for Lasers, Photonics and Biophotonics, SUNY at Buffalo, Buffalo, NY, USA.
authors.forename: Tymish Y
authors.initials: TY
authors.lastname: Ohulchanskyy
authors.forename: Atcha
authors.initials: A
authors.lastname: Kopwitthaya
authors.forename: Mansik
authors.initials: M
authors.lastname: Jeon
authors.forename: Moran
authors.initials: M
authors.lastname: Guo
authors.forename: Wing-Cheung
authors.initials: WC
authors.lastname: Law
authors.forename: Edward P
authors.initials: EP
authors.lastname: Furlani
authors.forename: Chulhong
authors.initials: C
authors.lastname: Kim
authors.forename: Paras N
authors.initials: PN
authors.lastname: Prasad
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D006046:Gold / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure; D008823:Micelles; D043942:Nanotubes / Q000032:analysis* / Q000648:ultrastructure; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D010743:Phospholipids / Q000737:chemistry; D061088:Photoacoustic Techniques; D010789:Phototherapy
chemical_list: D058185:Magnetite Nanoparticles; D008823:Micelles; D010743:Phospholipids; D006046:Gold
keywords: Gold nanorods; Magnetophoresis; Photoacoustic tomography; Plasmonic photothermal therapy