title: The correlation of parathyroid hormone and heart rate variability in CAPD patients.
abstract: OBJECTIVE
  To investigate the correlation of parathyroid hormone (PTH) and cardiac autonomic nervous system (ANS) measured by heart rate variability (HRV) method in continuous ambulatory peritoneal dialysis (CAPD) patients.
  
  
  METHODS
  Healthy subjects (HS) and two groups of CAPD patients classified by the PTH concentration: high PTH group (H-PTH; PTH = 150-300 pg/ml) and ultra-high PTH group (UH-PTH; PTH > 300 pg/ml) were studied. Time and frequency domains of HRV were analyzed. For the frequency domain, the fast Fourier transform of the total power (TP), low frequency (LF), high frequency (HF), and LF/HF ratio were transformed by natural logarithm (ln). The Pearson's correlation was used to analyze the correlation between lnPTH and the parameters of HRV RESULTS: Time and frequency domains of HS were at highest values whilst LF/HF ratio was the lowest. For UH-PTH CAPD patients, the values of standard deviation of R-R interval (SDNN), root mean square of the difference of R-R interval (RMSSD), lnTP and lnHF were significantly lower whereas lnLF was not significantly different compared to H-PTH. In addition, lnHF was found to have the highest negative correlation value with lnPTH concentration (r = -0.53).
  
  
  CONCLUSIONS
  PTH, a serious uremic toxin, influences the initiation of ANS dysfunction. According to decreased lnHF a decrease in parasympathetic activity was demonstrated in UH-PTH. Consequently, the modality that can stimulate the parasympathetic activity should be considered in CAPD patients who were hyperparathyroidism.
authors.affiliation: Department of Physiology, Faculty of Medicine, Srinakharinwirot University Bangkok, Thailand. weerasak_ussawa@hotmail.com
authors.forename: Weerasak
authors.initials: W
authors.lastname: Ussawawongaraya
authors.forename: Nuntana
authors.initials: N
authors.lastname: Spilles
authors.forename: Sirinun
authors.initials: S
authors.lastname: Nilwarangkoon
authors.forename: Amporn
authors.initials: A
authors.lastname: Jariyapongskul
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000378:metabolism / Q000503:physiopathology; D003864:Depression, Chemical; D005260:Female; D006339:Heart Rate; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D009200:Myocardial Contraction; D010281:Parathyroid Hormone / Q000097:blood* / Q000378:metabolism; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects* / Q000379:methods; D012107:Research Design; D013223:Statistics as Topic
chemical_list: D010281:Parathyroid Hormone