title: Ejaculatory activities of Allanblackia floribunda stem bark in spinal male rats.
abstract: BACKGROUND
  Medicinal plants have become a great source of relief for more 70% of the population in developing countries where access to modern medicine is very limited. Some of these plants are used as aphrodisiac agents. The stem bark of Allanblackia floribunda Oliver (Clusiacea) has been used in Cameroon as an aphrodisiac.
  
  
  OBJECTIVE
  This study was designed to assess the effects of Allanblackia floribunda aqueous and ethanol extracts and their potential mechanism on fictive ejaculation in spinal male rats.
  
  
  METHODS
  Electromyographic activities of the bulbospongiosus muscles were recorded in 24 groups of spinal rats after intravenous administration of aqueous and ethanol extracts (2.5, 10, 20, 40 or 60 mg/kg) from the stem bark of A. floribunda in the presence or absence of dopamine (60 mg/kg). Furthermore, electromyographic activities of the bulbospongiosus muscles were recorded in five groups of spinal rats pre-treated orally during 8 d with extracts (150 and 300 mg/kg) in the presence of dopamine.
  
  
  RESULTS
  Sequential treatments of rats with extracts significantly decreased the occurrence of ejaculation induced by dopamine up to 88.94% inhibition. The oral pre-treatment with both extracts significantly decreased the ejaculation induced by dopamine with the highest inhibition of 89.79%.
  
  
  CONCLUSIONS
  Two extracts of A. floribunda used in this study had inhibitory activities on ejaculation. The inhibitory effect of A. floribunda extracts on fictive ejaculation in rat may be directly mediated through dopaminergic pathways. Inhibition of ejaculation caused by these extracts could support its use in patients suffering from rapid ejaculation.
authors.affiliation: Department of Biological Sciences, University of Bamenda, Bambili, Cameroon. antoinekada@gmail.com
authors.forename: Antoine
authors.initials: A
authors.lastname: Kada Sanda
authors.forename: Pierre
authors.initials: P
authors.lastname: Miegueu
authors.forename: Danielle Claude
authors.initials: DC
authors.lastname: Bilanda
authors.forename: Messmer
authors.initials: M
authors.lastname: Faleu Nya Ngassam
authors.forename: Pierre
authors.initials: P
authors.lastname: Watcho
authors.forename: Paul Désiré Dzeufiet
authors.initials: PD
authors.lastname: Djomeni
authors.forename: Pierre
authors.initials: P
authors.lastname: Kamtchouing
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002163:Cameroon; D028084:Clusiaceae / Q000737:chemistry*; D004298:Dopamine / Q000008:administration & dosage / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004542:Ejaculation / Q000187:drug effects*; D004576:Electromyography; D008297:Male; D016488:Medicine, African Traditional; D010413:Penis / Q000187:drug effects / Q000378:metabolism; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018547:Plant Stems; D051381:Rats
chemical_list: D010936:Plant Extracts; D004298:Dopamine