title: The role of T cell immunity in HIV-1 infection.
abstract: The interplay between the T cell immune response and human immunodeficiency virus (HIV)-1 largely determines the outcome of infection. Typically, the virus overcomes the immune defences leading to a gradual decline in function that permits the development of disease. In recent years, a concerted effort in comparing T cell responses between 'controllers' and 'progressors' is beginning to identify the T cell subsets and factors that affect disease progression related to the effector functions of both CD4 and CD8 T cells. These efforts are providing opportunities for development of novel therapies and vaccines.
authors.affiliation: The Kirby Institute for Infection and Immunity in Society, University of NSW, Sydney, NSW, Australia.
authors.forename: C Mee Ling
authors.initials: CM
authors.lastname: Munier
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Kelleher
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Kent
authors.forename: Robert
authors.initials: R
authors.lastname: De Rose
mesh_terms: D000818:Animals; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007111:Immunity, Cellular; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology