title: Glycan-mediated modification of the immune response.
abstract: Aberrantly glycosylated tumor antigens represent promising targets for the development of anti-cancer vaccines, yet how glycans influence immune responses is poorly understood. Recent studies have demonstrated that GalNAc-glycosylation enhances antigen uptake by dendritic cells as well as CD4+T-cell and humoral responses, but prevents CD8+T-cell activation. Here, we briefly discuss the relevance of glycans as candidate targets for anti-cancer vaccines.
authors.affiliation: Copenhagen Center for Glycomics; Department of Cellular and Molecular Medicine; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen, Denmark ; Department of International Health, Immunology and Microbiology; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen, Denmark.
authors.forename: Caroline B
authors.initials: CB
authors.lastname: Madsen
authors.forename: Anders E
authors.initials: AE
authors.lastname: Pedersen
authors.forename: Hans H
authors.initials: HH
authors.lastname: Wandall
keywords: C-type lectins; GalNAc; carbohydrate receptors; dendritic cells; glycans; vaccines