title: Adult-onset leukoencephalopathy, brain calcifications and cysts: a case report.
abstract: BACKGROUND
  Leukoencephalopathy, brain calcifications and cysts, known as Labrune syndrome, is a rare syndrome. The etiology is unknown; in some cases it is difficult to differentiate from Coats plus syndrome and diagnosed as cerebroretinal microangiopathy with calcifications and cysts. We present the case of a patient with adult leukoencephalopathy, brain calcifications and cysts and discuss recently described entities in view of the relevant literature.
  
  
  METHODS
  A previously healthy 19-year-old Chinese man presented with weakness of his right limbs that rapidly worsened over a short interval. Computed tomography and magnetic resonance imaging showed numerous low-density cysts, calcifications, and abnormal signal change of white matter. A visual field examination showed irregular visual field defects in both eyes. A neuro-ophthalmologic examination did not find evidence of Coats retinopathy. A larger excisional biopsy was carried out and a diagnosis of leukoencephalopathy, brain calcifications and cysts was confirmed.
  
  
  CONCLUSIONS
  We present an example of adult-onset leukoencephalopathy, brain calcifications and cysts and have expanded the clinical spectrum of features associated with this syndrome. Previous reports have not, to the best of our knowledge, previously reported visual field defects. Based on the latest findings, we believe that leukoencephalopathy, brain calcifications and cysts and Coats plus syndrome are genetically distinct entities.
authors.affiliation: Department of Neurosurgery, PLA Navy General Hospital, Fuchenglu Road 6#, Haidian District, Beijing 100048, PR China. jnzhang2005@gmail.com.
authors.forename: Yaming
authors.initials: Y
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Cheng
authors.forename: Chao
authors.initials: C
authors.lastname: Dong
authors.forename: Jianning
authors.initials: J
authors.lastname: Zhang
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Meng