title: Synthesis, anticancer activity and photophysical properties of novel substituted 2-oxo-2H-chromenylpyrazolecarboxylates.
abstract: 2-Oxo-2H-chromenylpyrazolecarboxylates (8a-h and 12a-zb) have been synthesized by [3 + 2] cycloaddition of 2H-chromenophenylhydrazones (7a-h and 11a-w) with diethyl/dimethylbut-2-ynedioates. Phenylchromeno[4,3-c]pyrazol-4(1H)-ones (13i-n) were prepared from corresponding phenylhydrazones (7a-h) with catalytic amount of piperidine in presence of pyridine as a solvent at 100 °C. All the synthesized compounds (8a-h, 12a-zb and 13a-n) were screened for anticancer activity against three human cancer cell lines such as prostate (DU-145), lung adenocarcinoma (A549), and cervical (HeLa) by standard MTT assay method. Further, photophysical properties (UV and fluorescence) for these compounds were discussed.
authors.affiliation: Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, Andhra Pradesh, India.
authors.forename: J Ashok
authors.initials: JA
authors.lastname: Kumar
authors.forename: G
authors.initials: G
authors.lastname: Saidachary
authors.forename: G
authors.initials: G
authors.lastname: Mallesham
authors.forename: B
authors.initials: B
authors.lastname: Sridhar
authors.forename: Nishant
authors.initials: N
authors.lastname: Jain
authors.forename: Shashi Vardhan
authors.initials: SV
authors.lastname: Kalivendi
authors.forename: V Jayathirtha
authors.initials: VJ
authors.lastname: Rao
authors.forename: B China
authors.initials: BC
authors.lastname: Raju
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D055668:Photochemical Processes; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001578:Benzopyrans
keywords: 2-Oxo-2H-chromenylpyrazolecarboxylates; Anticancer activity; Phenylchromeno[4,3-c]pyrazol-4(1H)-ones; UV and fluorescence studies; [3+2] Cycloaddition