title: Photo-bio-synthesis of irregular shaped functionalized gold nanoparticles using edible mushroom Pleurotus florida and its anticancer evaluation.
abstract: A green chemistry approach to the synthesis of gold nanoparticles using edible mushroom Pleurotus florida (Oyster mushroom) by photo-irradiation method has been attempted. The mixture containing the aqueous gold ions and the mushroom extract was exposed to sunlight; this resulted in the formation of biofunctionalized gold nanoparticles. These nanoparticles were characterized using various techniques like UV-visible spectroscopy; X-ray diffraction studies, Energy dispersive X-ray analysis, Field emission scanning electron microscopy, Atomic force microscopy, Transmission electron microscopy and Fourier transform infrared spectrometry. The obtained biofunctionalized gold nanoparticles showed effective anti-cancer property against four different cancer cell lines A-549 (Human lung carcinoma), K-562 (Human chronic myelogenous leukemia bone marrow), HeLa (Human cervix) and MDA-MB (Human adenocarcinoma mammary gland) and no lethal effect is observed in Vero (African green monkey kidney normal cell) cell lines.
authors.affiliation: Materials Chemistry Laboratory, Department of Material Science, Gulbarga University, Gulbarga, Karnataka, India.
authors.forename: Ravishankar
authors.initials: R
authors.lastname: Bhat
authors.forename: V G
authors.initials: VG
authors.lastname: Sharanabasava
authors.forename: Raghunandan
authors.initials: R
authors.lastname: Deshpande
authors.forename: Ullas
authors.initials: U
authors.lastname: Shetti
authors.forename: Ganesh
authors.initials: G
authors.lastname: Sanjeev
authors.forename: A
authors.initials: A
authors.lastname: Venkataraman
mesh_terms: D000363:Agaricales; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D045424:Complex Mixtures / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D006046:Gold / Q000494:pharmacology*; D017612:Gold Compounds / Q000737:chemistry / Q000528:radiation effects; D006801:Humans; D053768:Metal Nanoparticles; D013472:Sunlight; D014709:Vero Cells
chemical_list: D000970:Antineoplastic Agents; D045424:Complex Mixtures; D017612:Gold Compounds; C038016:gold chloride; D006046:Gold
keywords: Anticancer evaluation; Biofunctionalized gold nanoparticles; Green chemistry; Photo-irradiation; Pleurotus florida