title: Mitochondrial response to oxidative and nitrosative stress in early stages of diabetes.
abstract: Diabetes mellitus (DM) is associated with increased production of reactive oxygen and nitrogen species; consequently, an increase in lipid peroxidation and a decrease in antioxidants resulting in mitochondrial dysfunction. Using a rat model of DM induced by streptozotocin, we show the opposite: an increase in NO levels, S-nitrosylation, aconitase activity, and total glutathione and a decrease in lipid peroxidation at early stages of diabetes. These data imply that the decrease in lipid peroxidation is a vital early response to hyperglycemia to prevent escalation of ROS generation in mitochondria. These results also suggest a need for novel therapeutic targets to prevent the neurological consequences of diabetes.
authors.affiliation: Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mich., Mexico.
authors.forename: Ruth
authors.initials: R
authors.lastname: Noriega-Cisneros
authors.forename: Christian
authors.initials: C
authors.lastname: Cortés-Rojo
authors.forename: Salvador
authors.initials: S
authors.lastname: Manzo-Avalos
authors.forename: Mónica
authors.initials: M
authors.lastname: Clemente-Guerrero
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Calderón-Cortés
authors.forename: Rafael
authors.initials: R
authors.lastname: Salgado-Garciglia
authors.forename: Rocío
authors.initials: R
authors.lastname: Montoya-Pérez
authors.forename: Istvan
authors.initials: I
authors.lastname: Boldogh
authors.forename: Alfredo
authors.initials: A
authors.lastname: Saavedra-Molina
mesh_terms: D000818:Animals; D002956:Citrulline / Q000096:biosynthesis; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology*; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D015538:Nitrosation; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D002956:Citrulline; D013311:Streptozocin; D005978:Glutathione
keywords: Antioxidant; Brain mitochondria; Diabetes; Glutathione; Nitrosative stress; Oxidative stress