title: [Relations between FANS, PPI and atrial fibrillation].
abstract: Recent evidence supports the existence of an association between the use of non-steroidal anti-inflammatory drugs and the risk of atrial fibrillation. Anti-inflammatory drugs are widely used for the treatment of systemic inflammatory disorders, and chronic inflammation is a well-known risk factor for the development of myocardial fibrosis. The latter accounts for atrial inhomogeneities of conduction, thus triggering and perpetuating atrial fibrillation. Atrial inflammatory remodeling may therefore be responsible for the higher incidence of atrial fibrillation among patients assuming steroidal and non-steroidal anti-inflammatory drugs because of an underlying inflammatory disorders. Alternative theories contemplate gastroesophageal reflux, which is extremely common during the use of non-steroidal anti-inflammatory drugs and may trigger atrial fibrillation, as mediating the above-mentioned association.
authors.affiliation: Istituto di Cardiologia e Centro per gli Studi sull'Invecchiamento, Università Gabriele d'Annunzio, Chiete.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Ricci
authors.forename: Raffaele
authors.initials: R
authors.lastname: De Caterina
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D001281:Atrial Fibrillation / Q000139:chemically induced* / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D005355:Fibrosis / Q000209:etiology / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy; D009206:Myocardium / Q000473:pathology; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012307:Risk Factors; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D054328:Proton Pump Inhibitors