title: [Age-related changes in the number of CD45+ cells in human dermis].
abstract: The aim of this work was the study of age-related changes in the number of CD45+ cells in human dermis. The results showed that the number of CD45+ cells in dermis increased gradually with age. At the same time, a total number of fibroblasts in dermis decreased with age. The number of PCNA+ fibroblasts in dermis showing their proliferative activity was observed to be decreased with the progression of age. The results of the correlation analysis show that the age-related increase of CD45+ cells number is statistically associated with the decrease in the total number of fibroblasts and with the quantity of PCNA+ fibroblasts in dermis through age. Therefore, accumulation of CD45+ cells in human dermis with age may be regarded as a mechanism which brings about inflammatory reaction and emergence of signs of aging. It is also possible that the increased number of bone marrow derived cells has an impact on the age-related decline in the number of fibroblasts in dermis with age.
authors.forename: V V
authors.initials: VV
authors.lastname: Petrov
authors.forename: O V
authors.initials: OV
authors.lastname: Vasil'eva
authors.forename: N K
authors.initials: NK
authors.lastname: Kornilova
authors.forename: A G
authors.initials: AG
authors.lastname: Gunin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D049109:Cell Proliferation; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D020405:Dermis / Q000196:embryology / Q000254:growth & development / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005333:Fetus / Q000378:metabolism / Q000473:pathology*; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D017493:Leukocyte Common Antigens / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D015595:Skin Aging / Q000473:pathology*; D055815:Young Adult
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human