title: Quality of life and depressive symptoms in Parkinson's disease after subthalamic deep brain stimulation: a 2-year follow-up study.
abstract: OBJECTIVE
  To assess the correlation between quality of life (QoL), depressive symptoms and motor signs in patients with Parkinson disease after subthalamic deep brain stimulation (DBS STN).
  
  
  METHODS
  74 patients, average age 55.6 ± 7 and duration of disease 12.3 years ± 3.8, treated with l STN DBS for PD were included in the study. All patients were evaluated with (UPDRS III), (PDQ-39) (BDI) at baseline and at 6, 12, and 24-month follow up. All patients were also stratified into three groups depending on UPDRS III improvement ( < 30%, 30-60%, > 60%).
  
  
  RESULTS
  Scores in all scales significantly decreased from baseline. The improvement in PDQ-39 was 43.3%, in BDI 25.3 %; UPDRS-III 55.5% at 6 months. At 24 months, motor results and QoL deteriorated by 15.6% and 19.6% respectively. BDI remained unchanged. Mean scores at baseline in PDQ-39 were group I 67.4 ± 29.7; II 64.8 ± 32.0; III 53.4 ± 22.0 and for BDI, group I 17.4 ± 12.04; II 14.0 ± 9.7; III- 15.1 ± 10.55. Scores decreased significantly with DBS at 6-month follow-up and mean change was: PDQ-39, group I 42.7%, II- 40.7%, III 51.6%; BDI group I 23%, II 28.1%, III 23.3 %.
  
  
  CONCLUSIONS
  Reduction of depressive symptoms, motor signs and improvement of QoL in PD after DBS STN are closely related. Improvement of QoL depends significantly on motor symptoms.
authors.affiliation: Institute Psychiatry and Neurology, Department of Neurosurgery, Warsaw, Poland. ttomasz@mp.pl
authors.forename: Tomasz
authors.initials: T
authors.lastname: Tykocki
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szalecki
authors.forename: Henryk
authors.initials: H
authors.lastname: Koziara
authors.forename: Paweł
authors.initials: P
authors.lastname: Nauman
authors.forename: Tomasz
authors.initials: T
authors.lastname: Mandat
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation / Q000379:methods; D003863:Depression / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000601:surgery*; D011788:Quality of Life; D020531:Subthalamic Nucleus / Q000502:physiology / Q000601:surgery*; D016896:Treatment Outcome