title: [On the role of gene of SER-4 serotonin receptor in thermotolerance of Caenorhabditis elegans behavior].
abstract: Serotonin reduces the behavior tolerance of Caenorhabditis elegans of the N2 wild-type strain (swimming induced by the mechanical stimulus) to a temperature of 36 degrees C. The sensitivity to the serotonin influence on the behavior thermotolerance remains intact in strains with null mutations of mod-1 (ok103) and ser-1 (ok345) serotonin receptor genes, and is almost completely lost in the ser-4 (ok512) strain with null mutation in the gene of the SER-4 serotonin receptor, which is a homologue of 5-HT1 mammalian serotonin receptor. In addition, nematodes of the ser-4 (ok512) strain have high behavior thermotolerance in the absence of the exogenous serotonin compared to the N2 strain. These data indicate the involvement of the ser-4 gene in the serotonin regulation of the tolerance of C. elegance nervous system functions to hyperthermia.
authors.forename: T B
authors.initials: TB
authors.lastname: Kalinnikova
authors.forename: R R
authors.initials: RR
authors.lastname: Kolsanova
authors.forename: R R
authors.initials: RR
authors.lastname: Shagidullin
authors.forename: E B
authors.initials: EB
authors.lastname: Osipova
authors.forename: M Kh
authors.initials: MKh
authors.lastname: Gaĭnutdinov
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D018118:Chloride Channels / Q000235:genetics; D005334:Fever; D009154:Mutation; D009420:Nervous System; D011985:Receptors, Serotonin / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D044348:Receptors, Serotonin, 5-HT2 / Q000235:genetics; D012701:Serotonin / Q000096:biosynthesis / Q000235:genetics; D013696:Temperature
chemical_list: D029742:Caenorhabditis elegans Proteins; D018118:Chloride Channels; C417030:MOD-1 protein, C elegans; D011985:Receptors, Serotonin; D044348:Receptors, Serotonin, 5-HT2; C515315:SER-1 protein, C elegans; C581334:SER-4 protein, C elegans; D012701:Serotonin