title: NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy?
abstract: Natural killer (NK) cells exert potent antitumor activity. However, NK cells infiltrating solid tumors are severely impaired in their function. Remarkably, NK cells isolated from malignant pleural effusions kill very efficiently tumor cells upon exposure to interleukin-2, offering an important clue for the development of novel approaches for tumor immunotherapy.
authors.affiliation: Department of Experimental Medicine and Center of Excellence for Biomedical Research; University of Genova; Genova Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Vacca
authors.forename: Stefania
authors.initials: S
authors.lastname: Martini
authors.forename: Maria C
authors.initials: MC
authors.lastname: Mingari
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Moretta
keywords: NK cells; cancer; immune response; immunotherapy; tumor immunology