title: A C(sp3)-C(sp3) bond forming reductive condensation of α-keto esters and enolizable carbon pronucleophiles.
abstract: The preparation of densely functionalized unsymmetrical 1,4-dicarbonyl structural motifs by a phosphorus(III)-mediated reductive condensation of α-keto esters and enolizable carbon pronucleophiles is described. The reaction, which is initiated by Kukhtin-Ramirez addition of commercially available tris(dimethylamino)phosphine to the α-keto ester substrate, proceeds rapidly under mild conditions.
authors.affiliation: Department of Chemistry, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Darla M
authors.initials: DM
authors.lastname: Fink
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Labutta
authors.forename: Alexander T
authors.initials: AT
authors.lastname: Radosevich
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D004123:Dimethylamines / Q000737:chemistry*; D004952:Esters; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry
chemical_list: D004123:Dimethylamines; D004952:Esters; D007659:Ketones; D010720:Phosphines; D002244:Carbon