title: Ancient DNA damage.
abstract: Under favorable conditions DNA can survive for thousands of years in the remains of dead organisms. The DNA extracted from such remains is invariably degraded to a small average size by processes that at least partly involve depurination. It also contains large amounts of deaminated cytosine residues that are accumulated toward the ends of the molecules, as well as several other lesions that are less well characterized.
authors.affiliation: Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany. jesse_dabney@eva.mpg.de
authors.forename: Jesse
authors.initials: J
authors.lastname: Dabney
authors.forename: Matthias
authors.initials: M
authors.lastname: Meyer
authors.forename: Svante
authors.initials: S
authors.lastname: Pääbo
mesh_terms: D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D053938:DNA Fragmentation; D003641:Deamination; D017422:Sequence Analysis, DNA; D013997:Time Factors
chemical_list: D004247:DNA