title: Choline associated hypersexuality in a 79-year-old man.
abstract: Hypersexuality, also referred to as sexually inappropriate behavior and sexual disinhibition, involves persistent, uninhibited sexual behaviors directed at oneself or at others, sometimes associated with neurodegenerative disorders. Choline is a water-soluble essential nutrient, used as a dietary supplement in different diseases. This report was aimed at considering choline intake as a possible cause of iatrogenic hypersexuality. After an evaluation, a 79-year-old man affected by memory loss was diagnosed with mild cognitive impairment and treated with oral choline. After 6 weeks of regular choline assumption, the patient showed a pathological increase in libido with sexual urges. As choline was withdrawn, the hypersexuality disappeared within 5 days. Since hypersexuality may be an underreported and overlooked adverse effect of drugs and dietary supplements acting on the cholinergic pathway, this should be considered when treating and counselling patients with inappropriate sexual behavior.
authors.affiliation: IRCCS Centro Neurolesi "Bonino-Pulejo", S.S.113 via Palermo, Cda Casazza, 98124, Messina, Italy, salbro77@tiscali.it.
authors.forename: Rocco Salvatore
authors.initials: RS
authors.lastname: Calabrò
authors.forename: Francesco
authors.initials: F
authors.lastname: Cordici
authors.forename: Carmelo
authors.initials: C
authors.lastname: Genovese
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
mesh_terms: D000368:Aged; D002794:Choline / Q000009:adverse effects* / Q000627:therapeutic use; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007989:Libido / Q000187:drug effects*; D008297:Male; D010262:Paraphilic Disorders / Q000139:chemically induced*; D012725:Sexual Behavior / Q000187:drug effects / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D002794:Choline