title: Non-alcoholic Fatty Liver Disease and Chronic Kidney Disease in Koreans Aged 50 Years or Older.
abstract: BACKGROUND
  Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share common pathogenic mechanisms and many risk factors, and both are linked to an increased risk of cardiovascular diseases. The aim of this study was to assess the association between NAFLD and CKD according to the presence of hypertension and diabetes mellitus in Koreans aged 50 years or older.
  
  
  METHODS
  A cross-sectional study of 1,706 subjects who received their routine health examination was conducted between May 2008 and April 2010 at Konkuk University medical center. Biochemical tests for liver and abdominal ultrasonography were performed. CKD was defined as either proteinuria or glomerular filtration rate ≤60 mL/min per 1.73 m(2).
  
  
  RESULTS
  Among the 1,706 subjects, There were 545 (31.9%) with non-alcoholic fatty liver disease and 424 (24.9%) with chronic kidney disease. In univariate logistic regression analysis, NAFLD was significantly associated with CKD (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.34 to 2.12). In multivariate logistic regression analysis adjusted for age, sex, current smoking, abdominal obesity, aspartate aminotransferases, alanine aminotransferases, γ-glutamyltransferase, hypertension, diabetes mellitus, hypertriglyceridemia, and low high-density lipoprotein cholesterol, NAFLD was associated with CKD (adjusted OR, 1.68; 95% CI, 1.27 to 2.24). This relationship remained significant after classification according to the presence of hypertension or diabetes mellitus.
  
  
  CONCLUSIONS
  NAFLD diagnosed by ultrasonography was significantly associated with CKD in Koreans aged 50 years or older.
authors.affiliation: Department of Family Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Ah-Leum
authors.initials: AL
authors.lastname: Ahn
authors.forename: Jae-Kyung
authors.initials: JK
authors.lastname: Choi
authors.forename: Mi-Na
authors.initials: MN
authors.lastname: Kim
authors.forename: Seun-Ah
authors.initials: SA
authors.lastname: Kim
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Oh
authors.forename: Hyuk-Jung
authors.initials: HJ
authors.lastname: Kweon
authors.forename: Dong-Yung
authors.initials: DY
authors.lastname: Cho
keywords: Chronic Renal Insufficiency; Glomerular Filtration Rate; Non-alcoholic Fatty Liver Disease; Proteinuria; Ultrasonography