title: The CYP11B2 -344C/T variant is associated with ischemic stroke risk: An updated meta-analysis.
abstract: BACKGROUND
  The CYP11B2 gene has been suggested to play an important role in the pathogenesis of ischemic stroke. However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the association of the CYP11B2 -344C/T variant with ischemic stroke.
  
  
  METHODS
  Published literature from PubMed and Embase were retrieved. Pooled odds ratio with 95% confidence interval was calculated using a fixed- or random-effects model. A total of seven studies (2765 stroke cases and 3118 controls) for the CYP11B2 -344C/T variant were included in the meta-analysis.
  
  
  RESULTS
  The meta-analysis indicated that the CYP11B2 -344C/T variant was significantly associated with ischemic stroke under a homogeneous co-dominant model (TT vs. CC: odds ratio=2.04, 95% confidence interval=1.21-3.45), dominant model (TT+TC vs. CC: odds ratio=1.67, 95% confidence interval=1.09-2.57) and recessive model (TT vs. TC+CC: odds ratio=1.56, 95% confidence interval=1.18-2.05) but not under a heterogeneous co-dominant model (TC vs. CC: odds ratio=1.43, 95% confidence interval=0.98-2.07). Further subgroup analysis showed that the CYP11B2 -344C/T variant was significantly associated with ischemic stroke in East Asian and South Asian populations, but not in a Caucasian population.
  
  
  CONCLUSIONS
  The present meta-analysis supported the positive association of the CYP11B2 -344C/T variant with ischemic stroke. Further large-scale studies considering gene-gene/gene-environment interactions should be conducted to investigate the association.
authors.affiliation: Department of Neurosurgery, Zhejiang Cancer Hospital, Hangzhou, China yangyu20130221@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
mesh_terms: D002545:Brain Ischemia / Q000150:complications* / Q000201:enzymology / Q000235:genetics*; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000201:enzymology / Q000235:genetics*
chemical_list: D019405:Cytochrome P-450 CYP11B2
keywords: Aldosterone; CYP11B2; ischemic stroke; meta-analysis; polymorphism