title: Steroid-responsive thalamic lesions accompanying microbleeds in a case of Hashimoto's encephalopathy with autoantibodies against α-enolase.
abstract: A 67-year-old man receiving antithrombotic therapy developed rapidly progressive amnesia. T2-weighted images of brain MRI revealed hyperintense lesions in the bilateral thalami accompanied by microbleeds. Antithyroglobulin antibodies and autoantibodies against the N-terminal of α-enolase (NAE) were identified in the patient's serum; therefore, Hashimoto's encephalopathy (HE) was suspected. Although the patient's radiological findings improved following steroid therapy, his symptoms did not improve, possibly due to increased thalamic microbleeds. Because anti-NAE antibodies are possibly associated with vasculitis, HE accompanied by anti-NAE antibodies may be exacerbated by microbleeds in patients receiving antithrombotic therapy.
authors.affiliation: Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan. y.yamaguchi830@gmail.com
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Manabu
authors.initials: M
authors.lastname: Wada
authors.forename: Haruko
authors.initials: H
authors.lastname: Tanji
authors.forename: Katsuro
authors.initials: K
authors.lastname: Kurokawa
authors.forename: Toru
authors.initials: T
authors.lastname: Kawanami
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Tanji
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoneda
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001927:Brain Diseases / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D004660:Encephalitis; D050031:Hashimoto Disease / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D013256:Steroids / Q000627:therapeutic use*; D013788:Thalamus / Q000098:blood supply* / Q000473:pathology
chemical_list: D001323:Autoantibodies; D013256:Steroids; D010751:Phosphopyruvate Hydratase